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<entry dataset="TrEMBL" created="2018-09-12" modified="2024-10-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LQG8</accession>
    <name>A0A2X0LQG8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C010g06100 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C010g06100</name>
        <name evidence="9" type="ORF">BQ5605_C010G06100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LQG8"/>
    <dbReference type="STRING" id="796604.A0A2X0LQG8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF1">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="454"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="496"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY14205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="522" mass="56152" checksum="3D7346C1588BDA3D" modified="2018-09-12" version="1">MSHSFHSGEEEKNVLSRAETGSIPVAKDASSDEAVVAHGRVVALHGPFAKVMTYLADRGVEARGLDRVPEDERIAQSGLQIFFFWMSVNLSFSSLAVGGLGSEYFGLDFRTSLAVIWTMAVVGCLATAYVATLGLSGLRTMALFRFAGGIPGTFICSFLNVLTQLSYSVTNALAGAQAFHAINHSLSLIVGIVVVSSVVFVLSIFGLAWVHRFARYCWIACFIIYCIILGLGTKGGYDVNRLTAQQATGKSLSAGILSFAGIMFSVASGWGVIAADYNVKLPADTPKWRVFFFTFFGTFLPIVFTCTVSATFQTLTELSYIAAFESDSLGGVVGAILGPLGGFGKFLLVLLGLSTIATNAPNTYSGSLAMQSLAPPLLKIPRIFFVVLFTAIYLIASIVGREHFSEIVSNFASILSYWTAFFIVIILLEFEWFRRPSGPLGKPDFDSFNDWKRLPPGFACVGAIAIAIGGIVPAMAQTYYTGPIAKAVEPGFGGDLGFEMSVGLSLVAYFVLRTIEVRVFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LS02</accession>
    <name>A0A2X0LS02_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="26">BQ5605_C013g07405 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">BQ5605_C013g07405</name>
        <name evidence="26" type="ORF">BQ5605_C013G07405</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LS02"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <keyword evidence="22" id="KW-0862">Zinc</keyword>
    <keyword evidence="22" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="24">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="25">
        <location>
            <begin position="349"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="SGY15562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="614" mass="67202" checksum="63A2A2967A562834" modified="2018-09-12" version="1">MLERREAFGDLNSTFTLPQGLPSSVAMPASVDAYDTWLREYMSIAQEIRDAKTSLNDVLTTHVLAMVPSCLDSFRLTFTDEQRNQRDLPELTTLTDRIRIQLRSAGLSTSHSAMIATTSPCPACHAPGHRLRDCTSRAQYPPAGPCRRCNKKGHWALDCKPRGGQQRTGDDNQSGMPSSAVHQPNVGYFASGLFARRQLPTDAFVVDSGATTHMVANRSLFTAYRQTAHTKIGGIAGGITAIGMGDVAFVAKTGHPITLRGVLHTPGLHVNLLSVSRLCDTDRVRLAFTSDGIDIAKDGQAIAHGTRKMIAAGLLHGFGAGYSDKDVEEFVCNACLGSKGHRLPFPDSESHSPERLGLVHSDVLSFPTPSLTGKRYLVTFLDDHSRKLWAYAIDHKSDVFPTFQTWLAEVELQTDARLRILRTDNGGEYRSNAFTEFCKSRGIRRQYSIPYTPQQNGRAERVNLSIVEGVLALLADSHLPATFWDEAAAYFVYCKNRCSHSALAKQTPELAWDGQRTTATALHPFGCAAWLTVAPDLRSKLDPKATRVIFTGYDLASKAFRFFDHSANKIVLGRNATFLDDDFPGLPANTPVDADNTECRANSGTLTATLEGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LSS7</accession>
    <name>A0A2X0LSS7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C011g06242 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C011g06242</name>
        <name evidence="2" type="ORF">BQ5605_C011G06242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY11706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LSS7"/>
    <dbReference type="STRING" id="796604.A0A2X0LSS7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="65"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY11706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="122" mass="13207" checksum="4B55F0B91446E246" modified="2018-09-12" version="1">MVTSTGLIVVASPPSVLCPQPELIALVSTRHPPLPKTSKDAMASPEAESWYAASVKELNSMGLHKVFKLSSPPTGARALGYRWVFTRKEDAEAKIISYKAQLVVQGFAPRLGIDYIKTLALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LTH0</accession>
    <name>A0A2X0LTH0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C014g07415 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C014g07415</name>
        <name evidence="2" type="ORF">BQ5605_C014G07415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY18623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LTH0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY18623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="184" mass="19723" checksum="B97BDD18B507A963" modified="2018-09-12" version="1">MRQSPLMSGEVGCRTEVVRGKLRNRKGARTGIGPAAGELARAPRQLRASKSPPQGGGLAGARPKWTLHIALPNQVRAYVLEGVVPATWTADQLAARDDAARELIVGSIDSADVSATLDAIPSDDLSAPRIFTALKARFAPDDATRTLELFALFDQLYYVSNVVIAKSDESFQHTYSINSTTSAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LTM7</accession>
    <name>A0A2X0LTM7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C014g07475</name>
        <name evidence="7" type="ORF">BQ5605_C014G07475</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY18793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LTM7"/>
    <dbReference type="STRING" id="796604.A0A2X0LTM7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13156">
        <property type="entry name" value="KOW_RPL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000014">
        <property type="entry name" value="60S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000915">
        <property type="entry name" value="60S_ribosomal_eL6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049633">
        <property type="entry name" value="Ribosomal_eL6_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041997">
        <property type="entry name" value="Ribosomal_eL6_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005568">
        <property type="entry name" value="Ribosomal_uL6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01159">
        <property type="entry name" value="Ribosomal_L6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03868">
        <property type="entry name" value="Ribosomal_L6e_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01170">
        <property type="entry name" value="RIBOSOMAL_L6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 N-terminal" evidence="6">
        <location>
            <begin position="3"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="31"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY18793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="244" mass="26315" checksum="D2B515C7FEE2E17E" modified="2018-09-12" version="1">MARNSDVSPYVGKFSRSQVYSKKGLYKREHKAALAPAAPAPETKTKTVGGKANGSSRTIPTSRAAKFYPSEDVKQLKRSRKSVQAPKLRSSLTPGTVLILLAGRFRGKRVVLLKQLDSGLLLVTGPFKVNGVPLRRVNQAYVIATSLKLDISSLAVDAKLNDAYFAKPKSASRNGTEGEFFADKAEKKAYPEDKVADQKAIDKAVLAAVNAKPNAAKYLAATFGLSKGQFPHLLKVSHQVSGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LU77</accession>
    <name>A0A2X0LU77_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL39</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L39</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C010g05919</name>
        <name evidence="6" type="ORF">BQ5605_C010G05919</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL39 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LU77"/>
    <dbReference type="STRING" id="796604.A0A2X0LU77"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1620.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein-like L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.10">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000077">
        <property type="entry name" value="Ribosomal_eL39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023626">
        <property type="entry name" value="Ribosomal_eL39_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19970:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19970">
        <property type="entry name" value="RIBOSOMAL PROTEIN L39E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00832">
        <property type="entry name" value="Ribosomal_L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48662">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY13628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="51" mass="6149" checksum="F335829BF6E39232" modified="2018-09-12" version="1">MPSNKSFRTKVVLAKAGKVNRPIPQWFRLKADTKLQYNAKRRHWRRTKLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LUB4</accession>
    <name>A0A2X0LUB4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BQ5605_C013g07120 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C013g07120</name>
        <name evidence="12" type="ORF">BQ5605_C013G07120</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY14832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LUB4"/>
    <dbReference type="STRING" id="796604.A0A2X0LUB4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010435">
        <property type="entry name" value="C5a/SBT2-like_Fn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF66">
        <property type="entry name" value="SERIN ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06280">
        <property type="entry name" value="fn3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015926456" evidence="9">
        <location>
            <begin position="21"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="10">
        <location>
            <begin position="179"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="C5a peptidase/Subtilisin-like protease SBT2-like Fn3-like" evidence="11">
        <location>
            <begin position="638"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY14832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="979" mass="105850" checksum="3641172F6266688C" modified="2018-09-12" version="1">MWACFSASLVTVTCAALASAHDPFSRSTIRHSRRYSLLPDTYILETECPDASILAEASPRTSGANMDSLVTEVLAAFPDARPRHVYDSALFCGLSVELGADSPHTQLLRIQRLKSVSPVRSIQLGVRTAGSSDTPFQAEASLNVVPRTEARGESDYLSSHVMLEVDKMHEMGLFGSRETLACVIDSGIDLMHPLLGNGCFGSNCKVVTGYDFVGDDGHSPKRSPQTSCSDHGTHIAGILAADKFKAFGFSGVAPNASLGVYRVFSCKGAASSDTFLKAMLMAADDGCRVLSLSFGKALGWDQDDGDDPFQKVVSRLATRGVFIAAASGNDASQGLMFAQTPADLAGILAVGSVEPVAAPRGFKLSFEHNRYPSMTYLALRPVNHSQTFQIHFHSIRRAKDTSCDPLLPRSSNFTNSVVVLQKGACGTKLIHFFVRHGARVVIAHDNGDPEQAQNWRRTAYAVHSQEGLEWLLKWPTSAVHTLLDHYLDSLGDLQVNFRSKDPVPQDELIDRVAGGLVSEYTEFGPAATLDTLAAHVSAPGSSILSTFPLNKGGYGVASGTSMATPMAAGVATLLISHRKDDHLTPAQIRSLMITTAGPVATKLNSVHPLTTVMQQGGGLVSAHRAYHAMTLIWPYALALYDTPRHVKDHVVTLTNTHKSVVTYSFNSVPSQTLAMYNKSAATEFNPSRASPIIQGSATVSFDPRQLTIAAGQKASFKVSIEQPAFSPSDLARYPTYGGWVVIHAQGDLVGTYRIPYFGIVGVLQQVPILDRSDYMTRGREKYAGLSYPFLVVGNNTGSGSGGTKHLSSPLDHKKSGVVSVSRARGLDVIYRLAMPTDRIYFDVIHAASSTASSHNASTARPHRVYPIRSSEPEPWTTVGPRETSLGSRFIGNWIWFSGLPRNTDEFAQEPVIDSNMGTFYGQLASSYGADAPYDIRLGSNVPVRFLVRALRLGATDNPEDYENQGVYDTWTSDPFEFID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LUD5</accession>
    <name>A0A2X0LUD5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphinganine-1-phosphate aldolase</fullName>
            <ecNumber evidence="14">4.1.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Sphingosine-1-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">BQ5605_C010g05989</name>
        <name evidence="18" type="ORF">BQ5605_C010G05989</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 16 17">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.27" evidence="14"/>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LUD5"/>
    <dbReference type="STRING" id="796604.A0A2X0LUD5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008117">
        <property type="term" value="F:sphinganine-1-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030149">
        <property type="term" value="P:sphingolipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000020">
        <property type="entry name" value="sphingosine-1-phosphate lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF6">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE LYASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16 17" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="16">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="SGY13841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="560" mass="60875" checksum="0BD1B2CDD90DA796" modified="2018-09-12" version="1">MSTRGVAPYLSPYISLIRSLVTLENSKQVVFWYVVQLYVLRLVRHLRATGVATAVHETYVATVKRGFKLMIYLIPSVRRKVQGELDSVTIDLEKKLAPKYDNLPPQHALPSTGLSKDEVIKTLEVHGSLPNTKWENGRVSGAVYNGTVEMGDIWREAFGRFEVSNPLHADFAYSAVLEIPGVRKMDAEVVAMCLSLFNSPLPTSAVDQNGGAGTTTSGGTESILMACKAYRDRAAAERGITRPEMIVPASAHAAFDKAASYFKIKIHHIPVDTETRKVNIKMVKRAINPNTIMLVGSAPNFPDGIIDDISALSKLAIKHHLGLHVDCCLGSFLVPFLERAGYPAEPFDFRVPGVTSISCDTHKYGFAPKGSSVIMYRSKALRRYQYSVMGAWAGGTYASPSMAGSRPGAIIAGAWASMMKMGIDGYTESCREIVGAAKRIVQGVSEMDDLYVLGDPLVSVVAFSSKTVSIYEVGDVMSKKGWHLNALQSPPALHIACTRLTVPVVDELLTDLREAVEEVKSQDKPGEGSMVMLYGLGSSSAIGPGLVEEMASRYMDVLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LV39</accession>
    <name>A0A2X0LV39_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C017g08500 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C017g08500</name>
        <name evidence="2" type="ORF">BQ5605_C017G08500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY20158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LV39"/>
    <dbReference type="STRING" id="796604.A0A2X0LV39"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052982">
        <property type="entry name" value="SRP1/TIP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633:SF1">
        <property type="entry name" value="GPI ANCHORED SERINE-THREONINE RICH PROTEIN (AFU_ORTHOLOGUE AFUA_1G03630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY20158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="397" mass="41199" checksum="4D7BA19A1885F3DE" modified="2018-09-12" version="1">MAPPHDGTTSSSRRRLHTSRNLRFSAVHTKTLMTLLAISSTLMVQAQNAVYPQPTDISGTGPKPPAVKSPANGTWATPSAPVTHGNGVHVPPASETGLGRQAHVRSATDFCLFMPPDPVNENLVDAEADAVAYCFNAVNGTRPMPDGFVQTAHFRKTANYVQVSGTYDWRKMNLNPYDCGGEYDNHGPSGTGNPVGAAIDGGQDFFQFLGSCDTVGVGQFVIRSCFGPRSYPYCRNTFDLMGSLWVAPGDYREPGFTSCSADSDLPVGVYNSSYTFAQGQSYTPPAVTAPSSSMCSTTASPSASGVTYAWAQSGYQQAISGGAASPTATESASATTSSSAVASSTITSAPTASAAASTTTQPAVATTTSSTSGVWHLVAAESALGMVFLSIVMAFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LWE9</accession>
    <name>A0A2X0LWE9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C012g06894 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C012g06894</name>
        <name evidence="2" type="ORF">BQ5605_C012G06894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LWE9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY16526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="272" mass="31478" checksum="7A9095F72EF1BDE5" modified="2018-09-12" version="1">MSETESPPPLQRIPLRVLIDRREYFLPEMMFRFFEVAIRRPEARFYMEAEAYSEALRLYCVQIATRLEQRSGWNLFSREVWAAWIESHKFYHGDRGLCNDYWRVIMYSGYRKYFYVSPRPPQLQSARTRRTYTHSLAIAQVINTLRDRFIAEYNAKHPKFDPPLQRSDNLIHRLGALPSFRRDRVVYFEGFEPTPGPGPSAFLDGELDHLKRRGGIRFDGKGVPTDFAVVVDAKSDLWPKDDEILGSAAVLPPGTASESQETDSGTQDACTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LX45</accession>
    <name>A0A2X0LX45_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C015g07898 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C015g07898</name>
        <name evidence="2" type="ORF">BQ5605_C015G07898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LX45"/>
    <dbReference type="STRING" id="796604.A0A2X0LX45"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046496">
        <property type="entry name" value="DUF6589"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20231">
        <property type="entry name" value="DUF6589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6589" evidence="1">
        <location>
            <begin position="218"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY17809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="474" mass="52605" checksum="25A76D04F03CEEDE" modified="2018-09-12" version="1">MAGEVLASDQIDARLDAIVESNSFISGRIRNLLSHCGDPPPVEESNCDNLISDSTAVDMEDAQEDSSGSDAERGRFKEQHVSFFCRSIMGQIAFGCNRRNNAMQHRNGLMALACGANDRLTTFLYDCGLTTSRRTTRRAALSLTMANLTLLKEIGSTRYFHVTLDNIDVAHHVNDEQLDRRSELLHGTFGYAHVQNGDVANAYDLQAYIAHRALLPPVDVNLFLPAEASEEAFATGFSAQMYRALARLVPHLGLTLHEPRCTPEPIEQLDVRKPDITLLQMMDKSDTSTADVAKVIDRLRMQLGLSEKEYADSVRILECDGGTSMLVESLRRNRFPFRRLYDGLGTTITVPGVAHLQWCIGAAIYRRCFGDPLEGSKYRGSLFITANLLGRKGLDPQKIKDYNQMERLLRDTAQQELLSCVGVCTGMVDHEGGSDVVDWRCGPKVRPVRRGWLIHVGAKSRPSGSVHEPAPSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M2G2</accession>
    <name>A0A2X0M2G2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C002g01371 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C002g01371</name>
        <name evidence="6" type="ORF">BQ5605_C002G01371</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY32500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M2G2"/>
    <dbReference type="STRING" id="796604.A0A2X0M2G2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12523">
        <property type="entry name" value="RRM2_MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000120">
        <property type="entry name" value="Negative regulator of differentiation 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000400">
        <property type="entry name" value="Negative regulator of differentiation 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF8">
        <property type="entry name" value="RNA-BINDING PROTEIN MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="327"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="418"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="549"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="640"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="181"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="719"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="728"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY32500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="783" mass="82695" checksum="8D6F2F54F1738CFE" modified="2018-09-12" version="1">MSITEVIQPAIYPSFAAAAAAASTSGSSSSFRTISKPIAANLSSLSLPLSTSTTIKMPIDPQALKQDFDAGVDKMRFATNAPTPGGDIVLGSGSASLQSSSSQAMLMNGGGRASSIPGSTLMNDAMTGGPINANDPPNYGPGGFGGAAASFISAHAPEMQQQPLGAFSPASPFFGAATLPPPPQVGSFGGSPALSSNGFSSPFLGQPGQATFEGHSAPQQQQNQNRRGVAQSTSPYATFGSPAHANGPTPNNGQPGFNATGMNGYGSPSMMGMMSPMMNMSLPQLGAPFANQGGFNSGQPNIFPMRPTANNLASLGQNNLNPTPTGRTVYVGNLPSDASVDELLSLIRFGPIEAVKIIPEKSCAFISFLDQLTAAAFHSDAVLRKLRLHENDLRIGWGKPTVVPAIVAQAVQQSGATRNVYLGNLDESTTEESLRDDLSRFGPIDQVKIVRDKNIAFVHFLSIGTAIKVIQALIAEPEYAGKRVSFGKDRTAYVPRSQQQQAQHNLAAAAMGQMAANYGMYSAFGSPHFPDGVGSQTLGSDPNGVPGNRTIYLGNIHPDSTTEEICNTIRGGILQQVRYIPEKHICFITFVEPQCALAFYQHASYQGLALHNRRLKIGWGKNSGTTPPGIAMVVQSGGSRNVYVGNIEDFERFSEERLRKDFGEYGDIELVNFLREKQCCFVNFTNIANAIKAIEGIKANPEYAGIKISFGKDRCGGLPRSYPSTQSRVRHHHHHHYHPQQAPLPGIGSPSVGAGHDGFDTSAMPHSSGLMLEDGANQSVAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M2J5</accession>
    <name>A0A2X0M2J5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01180 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01180</name>
        <name evidence="2" type="ORF">BQ5605_C002G01180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY30756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M2J5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY30756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="428" mass="47940" checksum="463102D904BE7A34" modified="2018-09-12" version="1">MLPACNPGCWMAPGLGQLANEIDLLSGSTCAIAQELQWAGINGIASSSDLTGYFEGHPDYKPRGLRSDARIRTNIPGTRHMLAVSSASNGPSIQADFDEAANPSGMDWDDERHSEYGGGHERDFSPAPYFSDRTSRMPIAPDYIATAERLSLADLRQVESFEPATRGQSKKETYKQFVFNDARLRSLERPALLRQYIAATVLKEYRTRIQDFDDILARIFTVPVDIAAEYEESRLFREILSPLYQECQRPLPEDEIRTDEDQEGSDRLFKMDPKGVPPFSRETCPGRVLGSVRKRTSHLASSAQTICNDGACQEYNIHSERSGQLALVHVPEPPKPPTDADREPERKKIWDSWIVECAHRWLALLRKQRETYRWMRKREEDAISEHSSATGQHSDHGSAAGSEAKSNLSALSELTSLSKLERGLDTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M3V8</accession>
    <name>A0A2X0M3V8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C002g01801</name>
        <name evidence="10" type="ORF">BQ5605_C002G01801</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 8">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY35778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M3V8"/>
    <dbReference type="STRING" id="796604.A0A2X0M3V8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004354">
        <property type="term" value="F:glutamate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.285.10:FF:000001">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000002">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000030">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.285.10">
        <property type="entry name" value="Glutamate Dehydrogenase, chain A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050724">
        <property type="entry name" value="Glu_Leu_Phe_Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006929">
        <property type="entry name" value="PRK09414.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43571">
        <property type="entry name" value="NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43571:SF1">
        <property type="entry name" value="NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="191"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="7">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY35778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="449" mass="48465" checksum="53197CAC7491706B" modified="2018-09-12" version="1">MSSQHSVVSEPEFEQAKNEIYSTLAPLFREQPELENAFKVLAIPERIIQFRVTWEDDKGVCQVNNGFRVQFSSVLGPYKGGLRLHPSVNLSILKFLGFEQIFKNALTGLHMGGGKGGSDFDPKGKSNSEIRRFCYAFMKELSRHIGASTDVPAGDIGVGGREVGFLFGAYKQLRNEWTGILTGKGYDFGGSRIRPEATGYGLVYYVAHMIQELEKADYTGKKVAISGAGNVAQFAALKVIELGGIVLSLSDSKGALVATGSTGFTPEQIHKIGELKLKGKYLTDLGQVEGFKWVAGDRPWTHFKSIDIALPCATQNEVSGDEAKALVAAGCKYVAEGSNMGCTQEAIDVFEAERTKSKTGTWYGPGKAANAGGVAVSGLEMAQNSSRIQWSSEEVDAKLKDIMENSYQLCFTTGKKYGKDGETPSLVAGANVAGFLKVVNAAKATGDWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M4M0</accession>
    <name>A0A2X0M4M0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C001g00910 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C001g00910</name>
        <name evidence="3" type="ORF">BQ5605_C001G00910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY50646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M4M0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY50646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="116" mass="13089" checksum="C2C240FC4D58A723" modified="2018-09-12" version="1">MSPRPSRAGAIAAVCIATIGIAIQRRIKRRRRRPVRNVRRPTPGRPTTSGRRWRLLSSNLDGQGIWRSKRSLFDQSETLLLNTTRAGGQDSSGQRRLQIWSFPRILGSGISSKERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M4Q1</accession>
    <name>A0A2X0M4Q1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C001g00940 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C001g00940</name>
        <name evidence="1" type="ORF">BQ5605_C001G00940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY50934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M4Q1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY50934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="100" mass="10769" checksum="1F41FE61C76355CC" modified="2018-09-12" version="1">MVRMTNMAADADGSRRHFSLPENTLRIRVRALVLGAKGDVVHHVRQVDDGGSMGSIVTASGHLGPRDGPQSEIGACAVHVFGRFGDRKRCRDMSSAVKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M572</accession>
    <name>A0A2X0M572_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">BQ5605_C006g03849 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C006g03849</name>
        <name evidence="13" type="ORF">BQ5605_C006G03849</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY54173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M572"/>
    <dbReference type="STRING" id="796604.A0A2X0M572"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20069">
        <property type="entry name" value="5TM_Oxa1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="YidC/Oxa/ALB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428:SF66">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEIN OXA1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="OXA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="400"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Membrane insertase YidC/Oxa/ALB C-terminal" evidence="12">
        <location>
            <begin position="323"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="192"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="558"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="221"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="562"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGY54173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="651" mass="70748" checksum="309A08AC677FEEAC" modified="2018-09-12" version="1">MRLRLGFRGSSAGAGESARHFSRQVSALTYCELIDSRRVRSPQIQDQVHHVRSKLLPEDNTEALGRYETLYKLYNASPRAVRRFAAHRAHTRLASHDPLQDTDALPDSIVHSLAHASYSAIASTSSLFLARPLVRSFSASTSSSSTRALVISGRRNWEPLSKAGISARRGFASSSISAGWIPSLQWRSNPAATEVTSASNGTGFVPEHSAAAPTPGAADIVTPSPATPSTTTPAEPSVSAAATAPPQTASTAAEAVDTSADAAATATEPTFYLPGDSHIFSGTLDLTSLAGSWGPHPIQRLQSMFLHLHESFPLMAPTTGLPWYILIPTVTIGLRMLLFWFQVRANANAARLAIIQPQLLAGMEKVKQAKSRNDLTSAQAAQMETAALMKRHKVNPIKNLVFPLAQGTVFMVMFFALKGLANAGLPLMAQEGFGWVQDLTQRDPTWALPIASSALTLATLELGVDKTTTVQTTTTKNMKMAFRFLLVISIPFIGYFPAALLLFWCTNNSISLLQSQILKLEPVRAFFNIPTPPPKALPGQKGYIKEPSFSEAFKNMQTATKEMSEQAAEKSRTHKESKNKDGQQLPRAEMYVPTNHSSKIGKVEEIARSLTPNGALKGAKGVIRAESPIELQDEKIRRVQAARKRRHKMKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M5W7</accession>
    <name>A0A2X0M5W7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00129 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00129</name>
        <name evidence="2" type="ORF">BQ5605_C001G00129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY44206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M5W7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY44206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="458" mass="47066" checksum="05FE7C606A4F909A" modified="2018-09-12" version="1">MSLSQDDLQAKAFQAHHEAVIEQAKLGTTTTTTIEPVFKPHQAHSLDQSQPQGLSSTQRMTEIKDQVSEKVGRVGEALVAPKPAEQLNETEASLTNVVTGFAGMAATAPLVAAEKLGPILTQTASQAQEMASSIASGATQKAREIGQSSREAMSNVAQSGSSMVSDAATRTQETMQHGFDKSKQTEQSIVGSASQGLESTGDRSTTSKSQVDDKPKSGGGAGLVSSVTSTAYSYLPESIQSYLPGGRSGNSNPPPQSQQQRPEREDNTTTSSTLQGASATATESGETTRDAKDKKVDATSSAAQRARDAVTSTQDAVDDSAISSTRSATAATMHGQGDASGFQKHPTSSSSSTGQDLFNPHSNAPASMMNLQSQRPETVYAAPFEANDNVPVLQSASGGLAPAVTAGRGHSTTISTHPVVQVSGLPPSAVHPAGASDLTYDPTVASLHPSAGASGPSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M5X3</accession>
    <name>A0A2X0M5X3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C006g04086 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C006g04086</name>
        <name evidence="4" type="ORF">BQ5605_C006G04086</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY55867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0M5X3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635:SF196">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="464"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="953"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY55867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1640" mass="180873" checksum="18450D34A2545B12" modified="2018-09-12" version="1">MDNNNNTNNASHAAIPPLRPDPPDPPGQAPATTTKSYSAAVGARSAAKHGNATANASTAVAAHPLMHNIENCVIINTPPSTSVEQVLLALDKYYPGLTGAMPCVIKGQRGLRFPKAADLDTLVANGLTVGKTLCKVEKLYSSTRGGVVQCTLTGFFSDPEGLCLFDEQIAAYGTVLRCRIQYIGKTKHISGVYDFILAFKDVDVLPPASLSIACDGVTERIPLRITGGMRHCVFCRSAAHVRKDCPVAPACKSCASTSHATQHCPARHASSPQGPPTSRAPQASTVTTAAPAAVSKSISPASAHDRTTKKRRVEQDLAAQTEDLSNRAQPDSLSKNARPEFSFNFPCKTATPPAPQPASNQGIAYSLVEKSSESPSSETTSPSPSPPPATPKSIITRSKSIAALSKPATREAPPTAPALEASEPSPEPPTKKPKTKKHLLRTWKTLWTKMMSTTKIPNVSFVAANVQSINEDRKRASLFSNLRSHNAEVFLLSETGRPSPERVAQWTQECQDLKLSALFTPFNNTAILWKSDSVVITFDPESPPNTLRASFSFPDRVTDATFCVGDSKVRVVSIYAPSSDKPDKKRFLSHLSTALRQVVRDEPSPPALLVGGDWNCVESQPLDSENQNGTNYGGQEMRDLATANNLFDAYRLHHPKGRATTNHSAPGTCRRLDRIYVSPDWVDLFHDHKIWAPVLKSTHSMVVARFQVPGAIDIGPGKFKLGLHVIEGDATCEYLTSIVRTLYNKALLQTPNDPPAAWTSTKHRLLPELQALARTFARFRRGGSEQERADHSRYGAALRSRLDPSLAGPSSIFIRLRKVRASDLIPSLTVNDVVHSDPDSMLGAASNYFERVYEDRPIDDAALKAIIDGLASTRLSPADSLKLEEAYPLEEMTKAQAACKSNSSPGPDGLPVEFYRATWPATGPILRDVINSIPTEARQPGPLPRNTAHIHLIHKRGERDQLSNKRPILLINADERIISQAHNQRLAPLLESLIGPTQRGFVPNRWIGTNIAEVQCLMDPGLPGSTPVSGMLALMDFEKAYDRLSHPYLDAVLCAVGLGPKARQWYRATYTNQSASVFLNGWLSATFDILSGVRQGDPLAPSLFVLAIEGFACQIRLRVKGIDIAGLQNVRELLFADDACCALHNLSDLDHLNRAIELYERASASKLSNIKSFLYPLGAFRDRSIAPDLGTWRLSDSQFRYLGIQVGVEIAEDAGWEDVKASTIARIRSIPMYDLPYAAKCSIINIYCYTKILYYSRFLPAPKSVVKEIEEAAMLAIHGRASDGTQRRPKVSRSRLCTPLDHGGFGLIDLPRRLAIDHAKWVFQLRAPDGCFTRHLFDIRIRLQAPNEPTPFTLSRPAPNQHRCTWIWIWWAYFCHPPPKWDHAVRKTTKLLPARWVRYFEAWALVTTLNPPELSKSQNLEQWATQVLYFPAGHGIQLSVNPALFRGPDGEVMTPSSFVNASKRHQVFIFPLIFPKGHQKVFDLPEQRWNAWWKALRKVRRVHSDAEDTGHLLSLGSLHPGSQVASPTSPHPNNRSTSCVMCLSEAPECLVHLAVGCPFARRLWSALSPTPHPVFVDFVCPVVSRSERRLVELRVLFFHSIWKLCRRRRFSSDLLEPITETEFEGLRASIQESKGRLVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M6C4</accession>
    <name>A0A2X0M6C4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C001g00108 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C001g00108</name>
        <name evidence="1" type="ORF">BQ5605_C001G00108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY44055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M6C4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY44055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="100" mass="11184" checksum="D8A1BC029C9A5F56" modified="2018-09-12" version="1">MAQEEHLEARRFFLTHQAHFGSYASSYDIKYNSFFFNSFFFLTGAHKLQSFGLAGTATKRAKGGYKATTASSWVKVKPLRAKSAAQIKTRRAPNADSNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M727</accession>
    <name>A0A2X0M727_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C007g04381 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">BQ5605_C007g04400 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C007g04400</name>
        <name evidence="1" type="synonym">BQ5605_C007g04381</name>
        <name evidence="1" type="ORF">BQ5605_C007G04381</name>
        <name evidence="2" type="ORF">BQ5605_C007G04400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY60110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY60261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M727"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY60110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY60261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="113" mass="12765" checksum="62B7E0696746F18F" modified="2018-09-12" version="1">MTDFQNLGAPLPHWLFAGMLVRSLPAQYDSIVGNLASDIDIHMDWNMFYPKLLMNVEMADSRNKQKESLSARIVDDTSLVARISTTAQKDYSKSYCSQQGLRGTPRLSSEIHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M752</accession>
    <name>A0A2X0M752_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C007g04517 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C007g04517</name>
        <name evidence="2" type="ORF">BQ5605_C007G04517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY61029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M752"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY61029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="144" mass="15452" checksum="66EA80F19BB27110" modified="2018-09-12" version="1">MMSASAPSRGAARTNIEVDAASSDEDQAAATRRRTSLRLDQLIVHKPPRLDLTHDYEVITPHARVITLPDDTSSPSTSALSLGNHHTGRPSSFLHPPRQGSDTGSSSASEEDDDWELLGMEDEAAVGPTVAPQVRTWASIVSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M8F1</accession>
    <name>A0A2X0M8F1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g03895 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g03895</name>
        <name evidence="1" type="ORF">BQ5605_C006G03895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY54638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M8F1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY54638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="148" mass="16310" checksum="FD0DDAEB0F765B7B" modified="2018-09-12" version="1">MLPYTRWNKPIRPTSSFRTRKTLSIPSLVHLSAHGSPRTARARSIGRDGDFLTTPWTAYDAERAFSAGRRTINQLQHATSGSLLNAKICVGSWAGAVAENDAARKKIDCSDRVTMIFTRELSYSAQPSKVVPAKRRATGTRGTIHLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M9Z6</accession>
    <name>A0A2X0M9Z6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C004g03150 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C004g03150</name>
        <name evidence="2" type="ORF">BQ5605_C004G03150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY70431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M9Z6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY70431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="137" mass="14683" checksum="C1CE057B4308F2C9" modified="2018-09-12" version="1">MRQSPLLSGEGARTGIGPAAGEIARALRQLRASKSPPQGGGLAGARPKHDLWAQAASDEFTAMRDDFKVFTIEPHSSVPPDATIVTSKFVWKTKRNAQGDITGRKARLVAVKSPLSARQRRLGRRAHPLARPLAVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MBL4</accession>
    <name>A0A2X0MBL4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C010g06072 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C010g06072</name>
        <name evidence="7" type="ORF">BQ5605_C010G06072</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MBL4"/>
    <dbReference type="STRING" id="796604.A0A2X0MBL4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000116">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit RPC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007832">
        <property type="entry name" value="RNA_pol_Rpc34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016049">
        <property type="entry name" value="RNA_pol_Rpc34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12780">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED , 39KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05158">
        <property type="entry name" value="RNA_pol_Rpc34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="296"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="301"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="329"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="395"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="418"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY14126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="574" mass="63480" checksum="DAB7032D2FB34AD8" modified="2018-09-12" version="1">MAPVASTSKAPATVKLTAAEKRLIEIGLAAPKGQITQAELLAKSNLTTQAVADAVNSILRKNLVQLLRTSTGSVEFRFIAKEEAKAMGAMDSDEKLVLDHIKDANNNGIWTKFLHNKTGLPRTTINKVLKTLEGRKVVKTVKSVKHPTRKIYMMSNIAPSVELTGGPWFTDNELDMEFVEALKKITLAYLTKQVRNPPRLKLGMSEEHQIDFLSFAHQTRPRSYKTKNAQPNELPRFPLWPVSASPRLPRVRDVLDYITESGIAVSVELNDEHVESLLELMIYEGTVERILVQTPADQGARRKKKDGAVKKRKRPMVSSDEEDSDGGARRQKKTKSKKGVAGRRRATNGKARKKSRLDSTALDDDDDDDDDSDASADFDEDEERGSDADDDAGKSKRKKKVRTRKPLRKVKPEDDDASSVTNDSTSESSASDRDEDDEEEEERLAALRHQREGGVNDYVYRTIREYHPVIGWTDMPCGKCPVESFCCEPPRRFAQASAVSASRGSRRPGFLSSGRPKIGIELEGGMKGVGMIGGAGAAIGISTAKWGETKGVVGNGVAPVNPRDCQYFKKWLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MC69</accession>
    <name>A0A2X0MC69_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C007g04824 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C007g04824</name>
        <name evidence="1" type="ORF">BQ5605_C007G04824</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY63738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MC69"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY63738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="100" mass="11454" checksum="DBCDB8691D118135" modified="2018-09-12" version="1">MCLSEAPECLVHLAVGCPFARRLWSALSPTPHPVFVDFVCPVVSRSERRLVELQVLFFHSIRKLCRRRRFSSDLLEPITETEFEGLRASIQESKGRLVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MCE6</accession>
    <name>A0A2X0MCE6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C013g07184 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C013g07184</name>
        <name evidence="1" type="ORF">BQ5605_C013G07184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY14965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MCE6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY14965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="265" mass="29916" checksum="3EE75A5652BC1B44" modified="2018-09-12" version="1">MSVEELADSMCILRREPNLAKLDKCRPMIVKQSRIRKMLRWLINESKKSAHSAVSFDGDCTARSTHWFRPGCAQPDLSSFCGGFSFDFDFGFRLGCSPSIGSTNSGWRLSRARQPSDKLVLSKLWPHLDPFGLVGFCVERNLKTSLDEQVNHLLNLYDSDFDANHVFRQLAFRVPTEKVARIGAALLEIEMDIVSEMIKKKSKDAKRYKATTEAEKQINRILAEGQSFGDKPHGTTAQMLGYANAFGMYTLFFTVNPADLHSPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MCL2</accession>
    <name>A0A2X0MCL2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C008g05296 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C008g05296</name>
        <name evidence="4" type="ORF">BQ5605_C008G05296</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY80063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MCL2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cDENN" evidence="3">
        <location>
            <begin position="876"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="381"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="489"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="599"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1389"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1509"/>
            <end position="1528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1553"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1627"/>
            <end position="1659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1712"/>
            <end position="1736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1759"/>
            <end position="1780"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1269"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="159"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="250"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="267"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="461"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="525"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="613"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1516"/>
            <end position="1525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1573"/>
            <end position="1611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY80063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1780" mass="192503" checksum="CD9B8530D7B0B106" modified="2018-09-12" version="1">MSKHGTPIAQRFASSTSLRARAQRDENTSAALVAGSAVPANSGRGSSAAPSHPAPQAASPTRSSVGHGRASSAASSVPRSLPPLQQHHSWSTASKHNSLTIKPTDDPFAVAGDDDWERMSDESVLGEADNGRPTGDEGKPPRRRPSILAGLVIKRRESTSSLSQSTSKAKSISSPRNSAQGPGAGATSSRFAPLRAASSLMSLRQGTKKDGNGSGPSSPRLRRSSSLERRSLGSIGGSLADDATTVSRTGSDRGSLKLFDSFRRRSPISTRQGPATSSDIEFPTSEDLGIGEQQSSISSKNGVEKIGVRTSVYTEDDRLAGLGLALTTDAPTRRVVPDNARLSIFSATTNNTADRSTLYSSIGSEYPSSLIRQRLGSTLSQGPTVHDVLEEEEPYDPASEEIEMAEDPNPPSAVQSDATANTSPQLSNQSSSNTLYSPLSVVARSPAQISYTEPPRSYPHSRSATIDSSTTSAAIRDHNVRMMANHVAMGEPQTSPPASPRPSESRQSVRTELGNSGGTHKEPTSAPSANPLSKTSKSMEKSFVNKPLATMYIVAGLPKDPATWSFTDFSDPGTPAPDHSPNAVPRFWRPEVLGCMTTNDESSPALDSLDCNTGTTTGRSSSRGGLHIQADSTSKPEFAALSKEEIAKMQAKATKLAFTRDVEILASTTQPPATVAHFPFVVQTSSKLSSVPAFSGSTAAAWESSLSARTLSSSCETTFYASCLNVWSHADTVRSNAIRVALHSGSQAKNYAVNKAVRAARSGKKLGAKLAKQLKSPMGAVLRDGRDWTRAGNETDTTEFDLETDGFGESSPAIVNAPVLVSELWLYNLAATESEWGDSAATASPLADLPVGLPLWLPYRSVATPPCLSPIKQLTFLTFSLILISHAPVYNILSDILRISWARLVLVSIQLSFVYVHRLLILHLYVCSYHQDIASHSLQMERILHFVAPRVGEQIRVPVSVATATAQNTYFVATMPGTLDWKTGGSLDHNFIMFPIFKCLHADNLLTIAEIALSPLGRVLFVSAHPIMLSLATFTFQHVLELRGWRGLVYPAVAARDIKIYLEDPGPWLIGVTSLCRSIALVDLQPEVVVVDLDSNTVNCDRPQPGSITSGLLRDKARKRLEVAIGNVGGHYGVPSDLVEAFPAGRFRPFDQVEVSGVVRDAERIKPSDSWAWDQERVIQTFDVILAEQPRTGLGRFFNAKKPRKLAELDPSAKHVQAVVRRHAKTFVDRRDESRKRPEADFAVLPQLASLMTESQEWQRSFDTFKSFSDKLTKESVELKTRLEKERREARRLTGTLSVEKKRQADLEASLSATERAREQALSELSNVQAIRDDLERQQQMLMTEMHLILATDSDSSPLVETVFARIEALSSRSDASSRPETAQSLRAHLNRRAGSSDGGTSPLPPTAEEEITTECSKPSLNIDDVEDPEKMDAMRAAVQETLRSIQSRLQIVLRNAESIGQHSNDHRISIDSTLVSGSVVDLLEPRRASTSTIGQAFGEDETVTINIPQASAGRPRPPGGPLPETPVQASRTSIVSTAESDASFHTFRTARQPNSGVKYREPRRFQPKPFSLTPSPTVTSADVRSTSPMSEHNRCFSGTRSVTNGSPRFQNHAANESIMSIASFHDARDGSSTTPEPNPPESAGGLRLNENGSIADSDDTARYSQETLDLEGRSSFGLDDREFQSRHHRVNSGDGSTDIDDASFVSVYESLDGDHEEEPVSARQTPEPPERSVSRQFFTPVSSTAEAIETPPVELFTRAKSPPARMLQRRSVGGEMAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MDQ8</accession>
    <name>A0A2X0MDQ8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP-2 complex subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C004g02928</name>
        <name evidence="10" type="ORF">BQ5605_C004G02928</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Coated pit</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY68897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MDQ8"/>
    <dbReference type="STRING" id="796604.A0A2X0MDQ8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000020">
        <property type="entry name" value="AP-2 complex subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017104">
        <property type="entry name" value="AP2_complex_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003164">
        <property type="entry name" value="Clathrin_a-adaptin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02296">
        <property type="entry name" value="Alpha_adaptin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037091">
        <property type="entry name" value="AP2_complex_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0168">Coated pit</keyword>
    <keyword evidence="3 7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin adaptor alpha/beta/gamma-adaptin appendage Ig-like subdomain" evidence="9">
        <location>
            <begin position="751"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="13"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="58"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037091-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY68897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="989" mass="110121" checksum="FD809D2894DAF768" modified="2018-09-12" version="1">MLRVPNMNKDEMRGLTQYIADLRACRVRELEEKRINKEMAHIRQKFKEGNLDGRQKKKYISKIIFTSILGYAVDVGHMEAVNLISSTKYSEKQIGYLALTLLMHENSDLVRLIVNSIRKDLDGLDETVNCLALHAIANIGGAEMTEALASDVHRLLISPTSRSFVKKKAALTLLRLYRKHPGVIPSAEWASRIVSIMDDQDLGVALAVASLVLTLAQDNLSAYTVAYQKAVERLAKIVLENEYPSDYLYYKVPIPWLQVKLLRLLQYYPPSEDANLRLTLHKVLERTLKNSQDTPKNPQHNNALNAVLFEAINLAIHLDTESSIVHSAALLLGRFISAKETNVRYLGLDTMTHLAARSESLDAIKVHQNVIIQSLRDKDISVRRRGLDLLYSMCDTSNSKVIVSELLKYLPIADYTLREEMVLKIAILTEKFAVEYEWYVDTILKLMSTAGDHVGDEVWYRIVQIVTNTEELQEYAAQKVFHHLSLPNCHENILKVGAYILGEYGHLIADEEGRSPIEQFQLVTSRANFASASTKALLLTTYFKWLNLFPEIYEQIVNLFERYSRVLDAELQQRACEYLVIAKQPDDELLQVVADEMPPYPERESALVSRLLKKHGDTGDKRTWHIGGKDVNRGQDAERYKGFGRRKMNPTADATGAAPIDATTVGRSKVIPEVDTTDVMSSLAGLDLSSSTVERGESSLAPSPLAPALSPAAGKASLPLLGAATSSTATTPTTSRKTSLPLTHGSEKWLARLLYNPDGVLYEDTQLQIGVKTEYHGHQGRIAIFFGNKLSVALESLTATFDVEDEDALEIKLPSIVPSHLSASTQVQQLVLVEGKSIFSTPPLLRISYLAGSHQELVLRLPAFLTKFIEPVQLSSDAFFERWKQIGGAPREQQKIFPIVILEGGRVDVAKQRKVVGGLRMGLLNGVDPNPNNLVAAGVLHMSSVGKVGCLLRVEPNPERKLCRLTVRSTNEQVSTEMLRLLVGALAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0ME25</accession>
    <name>A0A2X0ME25_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C004g03028 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C004g03028</name>
        <name evidence="2" type="ORF">BQ5605_C004G03028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY69525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0ME25"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY69525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="493" mass="53803" checksum="1231897D8C87432F" modified="2018-09-12" version="1">MPVPQTPSSDSDSDEPNLGDSSQSSADDSDSESDSHSHSESEFEDVAIDHRRAIRLWTAIHGSHRNATGRMSQRKWTSLKRWAARRYYSELKMAAKLGISHARLVQAVKKFNRLASKGNAWSRFLSDPVIKVLHQRASKESDQSKSQSITKLAAHLWNFLRDQGGLGSAQLGEDDEELVRAAFAAAEAGGNTTFTSIVPPTIITRSPSDIPSPTRMEQCKKYIAELRDLAQRMSKLYGVETLAFIVPRYQDDVSPATKATVHSIGGLRFAAHCNGFKDPSGNSLLSNFASKMSWDETLKANEAADLKEVLLVAFLANDTALCSAPNSVNSALETIHRRSDTGSSTGAFTPQKKMIWSTQGLKALGVKLRIKPGTKSRYEMALHHSAETSPKQTVAQLKAIIDDLRHGRLAIVPSADPNDNTEAEASDNDLNGGEGPLSPRFGGAGDEGGEVRGGEKSGEEDREKNSGGDRRMNEAKHRRCETVLMSFFGHTML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0ME44</accession>
    <name>A0A2X0ME44_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">S-formylglutathione hydrolase</fullName>
            <ecNumber evidence="2 7">3.1.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C005g03481</name>
        <name evidence="8" type="ORF">BQ5605_C005G03481</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Serine hydrolase involved in the detoxification of formaldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-formylglutathione + H2O = formate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14961"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="3.1.2.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the esterase D family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.12" evidence="2 7"/>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY76295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0ME44"/>
    <dbReference type="STRING" id="796604.A0A2X0ME44"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018738">
        <property type="term" value="F:S-formylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000002">
        <property type="entry name" value="S-formylglutathione hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014186">
        <property type="entry name" value="S-formylglutathione_hydrol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02821">
        <property type="entry name" value="fghA_ester_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061:SF0">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0719">Serine esterase</keyword>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR614186-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY76295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="294" mass="32283" checksum="467E5E4D9677E415" modified="2018-09-12" version="1">MSLEQIAQNFTFDGTLTKYKTKSVSLGGLETQFNVFVPKQASASFKVPALYYLAGLTCNEDTAAQPAISRCPWKGGFIRDAAQEGIALVFPDTSPRGANIEGEAKDWDFGTGAGFYLNATHEKYAKYYNMYDFITSELPSLLSTLPIDTQRSSIFGHSMGGHGALVLYLKTKGQYRSASAFAPITNPTKAPWGEKAFSGYLQGGVKEGQAYDATHLIAEAKGQDLHILVDVGTGDDFYKKKQLLPENFIEAAKKAGFSEEQVKVSLHEGYDHSYYFISTFAPGHVKYHAKYLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MEL3</accession>
    <name>A0A2X0MEL3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C009g05819 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">BQ5605_C038g11669 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C038g11669</name>
        <name evidence="2" type="synonym">BQ5605_C009g05819</name>
        <name evidence="2" type="ORF">BQ5605_C009G05819</name>
        <name evidence="3" type="ORF">BQ5605_C038G11669</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY86464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000061">
        <property type="protein sequence ID" value="SGY91459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MEL3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY86464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY91459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="70" mass="7303" checksum="051CA4EDD772744E" modified="2018-09-12" version="1">MRQSPLLSGEVDCRTEVMRGKLKNRKGARTGIGPVAGEIARALRQLRASKSPPQGGGLAGARPSPLAPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MF41</accession>
    <name>A0A2X0MF41_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C014g07417 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C014g07417</name>
        <name evidence="25" type="ORF">BQ5605_C014G07417</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY18630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="490"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="773"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1361"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="826"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="863"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="1363"/>
            <end position="1383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGY18630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1383" mass="150639" checksum="05A84278964FDA76" modified="2018-09-12" version="1">MSAAGAPAPDAKLREPPPDAPPLRPPTHSAAFATTELLHNSSGYRDWVLAIRSRLPSGVVRYLNTGVPLESWAASYVPLWDHYASSSICASVDSQTVLPGLSPYLDKSLAAPKVWQALRERYGTVSAVDLLPVIQRLFSSDPVPVTPDLFLQFRDSFENDARLLQDSQVTVNALLASHLLARLPSSFDAWRTTFVADQGDSTAMPSATEIFTHLYRDVKARPVDTPVAAVATPQARHGCSRPCPNPSCRKLHWLRECPDTAWAAAYRARRTAEKKASQPVASPAAVDTPNSVSFTACLLATPSPFRKLAWLLDSGANRHMTNDRGLFSELRTVAGPRVGGVAGSLPSTGCGTICIQTSTGPITVSNVLLVPDLPCNLLSVFQLDQLGYRVSFASRCASIARPSGAVVATAQAIGNNLYALALGPTPCTPKALLAIPANVSLLTLHRRLAHLPVAQIKNIVQSGLVTGVDWVYKDQELRDFYCNACLASKAHALPFARSKSIASGRLDLLHVDVAQMPRPTFGGHRYMLVIIDDFSRKHWCILLALKSDVFPRLRDWILEVENATGNKVKTIRSDNGGEFTLGNFVDFCASKGIRRELTIPYTPQQNGRVERSNRTIKEGILALLYSSGADSRLWGEAALYYVHCKNLMPHAGIGGEIPDTRWHGFAPDISTLCAFGCRAWHHLPSAKRTDLDPKAVPLLFVGFDQHAKAFRLFEPSTRRIQLSRNVVFRESEFPALRPATDVCAEPIPLPVTVDAYPDQVDPLEPLLVASPRSLAPRAEPPRPVPAAPDQGPHRPAPAREVPDQDSLAPPAPDQGSPARELPDPESPASSASDQGSSDSAISTPCPSPRPVASRALPAPPSPARSDSPDPIDLLPRPRDVASLCQAQEFPDDVDDALHSPSAVAYLASGAAALIETSPADPAELIAPARDPPHWRAAMATPQADEWRLAARDEFDSLLRDFSAFTPIDESLVPADAKVLGSRFVFRTKRDQHGQVKSYKGRLVARGDSQRSGIDFDETFAPVAKFTSIRALLALAAAHGYHVHQADIDKAYLHGKLDAPLYIRVPDGIYMPGKVLQLHRSLYGLRQAGRIWNDEIDSALSALGYVATESDHCVYVRTTGDVHHYIALYVDDLLMISPSLPEIERTLQGLEQRYGVKRLGEAEYVLGIQIRRSPDGSISLSQEQYLKDVLARFGMSDAHPVATPMQPDLRLEVELQPTPFPDRTRYLQAIGSLMYASTGTRPDLAYTVGYLARFSHSPSAAAWGAVKHTFRYLAGTLSHGLRYARGNPAPLLGYSDCNWGACVLSSKLTMGYTFVYAGAAVSWSSRLQSRVADSTCDAEYLALSHAGYETITTNVRRGWLSNRSGEREAKKQKGGPHWDRPSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MF69</accession>
    <name>A0A2X0MF69_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">pyridoxal 5'-phosphate synthase</fullName>
            <ecNumber evidence="4">1.4.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C037g11606</name>
        <name evidence="10" type="ORF">BQ5605_C037G11606</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="4"/>
    <dbReference type="EMBL" id="FQNC01000062">
        <property type="protein sequence ID" value="SGY93728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MF69"/>
    <dbReference type="STRING" id="796604.A0A2X0MF69"/>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01629">
        <property type="entry name" value="PdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019740">
        <property type="entry name" value="Pyridox_Oxase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004231">
        <property type="entry name" value="PRK05679.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851:SF0">
        <property type="entry name" value="PYRIDOXINE-5'-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PYRIDOXINE-5-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01064">
        <property type="entry name" value="PYRIDOX_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="8">
        <location>
            <begin position="104"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridoxine 5'-phosphate oxidase dimerisation C-terminal" evidence="9">
        <location>
            <begin position="273"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY93728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="316" mass="34912" checksum="A42642AB4FD8CD03" modified="2018-09-12" version="1">MSLPCQPRLGGTSSSLLSLCHRNPFPTWTTTTHSLRPNILAPTPIPHSQHSSMSSPTPQAQIKIDNHETYLSQGIPSASSLSPDPIAQFREWFSSALADKDVIEPEAMTVSTVSAEGIPSTRVVLLKQVDDKGWIFYTNYESRKGRELFPQTETEAETGTETRGSYASLAFYWRALHLSVRVVGRAEKVTPQETKTYFDSRPVGSRIGAWASKQSSELSGREELEEQVKAMEWQFGVPEGTSIGTASAVAAGPKGQNSSKEAENVDVSVPPFWGGVRIVPFEVEFWAGRPSRLHDRFRYTRDEGSDGAWKIVRLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MH86</accession>
    <name>A0A2X0MH86_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C009g05441 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C009g05441</name>
        <name evidence="1" type="ORF">BQ5605_C009G05441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY81022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MH86"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY81022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="68" mass="7653" checksum="7F5BAD946EF514A2" modified="2018-09-12" version="1">MRTVKPGVLDTCSQNRTKQTAKYNSRRSRAVILPIKSLHFVRGKTGCFGFSLLRSCEPTRSGLVWSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MI15</accession>
    <name>A0A2X0MI15_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C009g05532 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C009g05532</name>
        <name evidence="2" type="ORF">BQ5605_C009G05532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY81892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MI15"/>
    <dbReference type="STRING" id="796604.A0A2X0MI15"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY81892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="485" mass="51680" checksum="3A418EA6A09F58A8" modified="2018-09-12" version="1">MPPPTPRRRTPAKNANTSIFTFQAPSIRIPTFNSPIKRLKTPTTDDLDGAQTRDEARQARLRGPAGQTWNNLNTLLTRGPTKLPSFSAVPGANSRAGRPKNATPGGPKNPKAPKTPKKTPKTPSKAESTKKSARKSSVAAKTRVLQPTPRSATRSAAATATTAALKTKAAVAASAGPKSNQRRNGKRNALPSSPLGSHRSNAETEADREVEQVDEPVQVEAPPPPDPPLIASTSKGKTKAPPKRVPAKKVAPVKVSRAVAIRRRKPAVEPEPEANSDDSEIKVVDRRIKPKALAKKVPPAATQSISSSPPPPPASEKLDLEEINEPMLPLASTSRATIKAPSKRAATRTKSARGSKAVAVRQQRKESPDHDDQSAENVRTEKQPVKKKPIGRKHTAPKAKARSAPAETSEPEDDVVTLLRPSKHTLDEDLDGSISDSSFDDGPVVKRRKSGGSASAFDNAKNKSSAPSSLDTIFAGVRSKMVEKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIN4</accession>
    <name>A0A2X0MIN4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C036g11474 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C036g11474</name>
        <name evidence="6" type="ORF">BQ5605_C036G11474</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000063">
        <property type="protein sequence ID" value="SGY95149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIN4"/>
    <dbReference type="STRING" id="796604.A0A2X0MIN4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050995">
        <property type="entry name" value="WD-F-box_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604:SF4">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604">
        <property type="entry name" value="WD40 REPEAT PF20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="284"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="569"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="609"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="657"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="697"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="737"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="779"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="223"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="351"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="410"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="410"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY95149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="862" mass="93098" checksum="5BD2D8B67BDC4511" modified="2018-09-12" version="1">MYGMQGEHASPSGSKADEEEQRPSPATLEDVPSRPLNMRPHPRPAPSTSRKTTAAMTSIQSSTSAPTRSLVHLWHRLSGSPSTSTGPRDVENERDPNQDENHAEGANDEDATSDGDHEPDVPGRMHRRSTSVPYASSSAAPHPPASPPASSSAAGFLSSHFSIDPEPVLSRLRRVQHQRTPTQLNRSPASPTSPSAAAAAGSLSPSRLSESWDRFRPRWPHLGAGSPGFHANSNSSGKAAPTQGSANSDDSDHDASALNEVLDGDEGVVVDDEACFVEGSQGKVDFLCSLPIEISLFILLHLDHVTLLEASAVSRTWRLLALDNVIWRDLFHQHAGWRIREPFAPSVASTIYHDAPSKPPSIRRAVTSAMRRDGSRRSNAGGEASGSGPETPTRLVRRISDMVDTLGSLSLTPLATRATPTRETAEDPMSASMGSDSSWAHASQILPGAIPRRTAPSVISTAPPSTSTVATNAFAAPPRTHSSARVPLSRAGSSSALANLASSIAHLPPSLGPSRRNSSATLPPLGSIPSPLLGSIPSAPLTLNWPRLFRDRYLVEERWKRAAPRSNWYKGHTDSVYCLQFDPKKIISGSRDRSVRVWDIATGRTTKVLTGHEGSVLCLRYNDKVLITGSSDSTILVWDLVGDPITGRGQWEATMQLIGHNMAVLDLTFDDQWIVSCSKDTTIRVWHRSTGELYRVLAGHRGPVNAVQLHNNRVVSASGDATMKMWNVLTGEVERVFTGHERGLACATLSASGTLVASGSNDKMIRVWDVTTGTCLAVLRGHTDLVRSLAFDEARGLILSGSYDRTTRVWDWKSQSELAKYKQHTSLVFHVEFDASRIISSSHDRKILSLDFGEGLDTSLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIP9</accession>
    <name>A0A2X0MIP9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C009g05782 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C009g05782</name>
        <name evidence="3" type="ORF">BQ5605_C009G05782</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY85835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIP9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY85835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="243" mass="25612" checksum="F7A8A921B409547C" modified="2018-09-12" version="1">MPRTPNSRPRTSSPTLWLTTAVVAFVGVVVVGVVSGWNASGERSNSEGKSSGGGNATKGKGKKREGDDEHPTDQTTSTSPSVSLPHLKEYKGTLALLMPSAPTSSLLSLLSRPHSAGGITTIYILYPIPKPDRDQPTLPLSSASIERSIPSSVHLLPYTEPNSPIHMCKALNPGYILLLPLTVDQLVLTTPNKTSSSMTTPILSLQDLQKGLQGFGGNGRQKSILNVDDGVEGLAKAFGFLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIS4</accession>
    <name>A0A2X0MIS4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C009g05812 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C009g05812</name>
        <name evidence="7" type="ORF">BQ5605_C009G05812</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TDE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY86347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIS4"/>
    <dbReference type="STRING" id="796604.A0A2X0MIS4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005016">
        <property type="entry name" value="TDE1/TMS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383">
        <property type="entry name" value="SERINE INCORPORATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383:SF9">
        <property type="entry name" value="SERINE INCORPORATOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03348">
        <property type="entry name" value="Serinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY86347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="509" mass="54884" checksum="95CA90F7F577B36D" modified="2018-09-12" version="1">MGAVLGLPLLGSLAGLSASAASAIIGGFAFFCTGQAASALTKSCNCNSSVATRVGFSIIFLLNSLLAWLMLSDWAIRAIAKWSYDYIKMSCAEGRCYGVLAVHRINFALALFHAILALLLIGVPDTRTRRASIQNGWWGPKVAAWIVLVIVSFFIPNGFFMFYGDCQSFPDISLVGATVFILIGLVLLVDFAHSWSETCLERWESTDSPFWKWTLIASTLGLYIVALVLTIIQYAFFAGQGCGLNRFLITLNLLVSLAVSGLSIAPAIQEANPRSGLAQSGMVVAYTAYLVTSAIANHDDDSIEGQCNPLTSRAAGARTGMVVLGAIFTFLAIAYSTSRAATQSKALVGKGAKRNVSEGSYGALSSEDGELVTVVSNQPNRKESLRYQALQAAVAEGSLPASVLEEDDEDEDALATDELDDEKAGTRYNYVWFHVIFIMATMYVAMLLTNWNVVTTASFIPDLSGDATPVRIGRSGRAMWCRIVSSWVCTLLYAWSLLAPVMMPDRFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIS5</accession>
    <name>A0A2X0MIS5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C028g10525 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C028g10525</name>
        <name evidence="8" type="ORF">BQ5605_C028G10525</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000080">
        <property type="protein sequence ID" value="SGZ12778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIS5"/>
    <dbReference type="STRING" id="796604.A0A2X0MIS5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070916">
        <property type="term" value="C:inositol phosphoceramide synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006676">
        <property type="term" value="P:mannosyl diphosphorylinositol ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03386">
        <property type="entry name" value="PAP2_Aur1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052185">
        <property type="entry name" value="IPC_Synthase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310:SF11">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE CATALYTIC SUBUNIT AUR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="175"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="381"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGZ12778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="432" mass="48087" checksum="06C1D3185CB3AA29" modified="2018-09-12" version="1">MTIRLSPYLQQRVLAAASRLEINFDPRVGLARVQRYGWQWKRDWPYAFLVIVALFSLCVMPQHILFKVFLVGIYTTALLVPFTSQFVLPATPIFGWLILFFSSQFIPTKYRPHIWVSVLPTLESVLYGANISDILTRYTSPFLDVLAWIPYGVVHFAGPFFVAAFLFVFSPPGALKFWGSAFGYLNLVGVMIQIMFPCAPPWYEIREGLIPANYGMHGSPGGLARIDAIFGGNGYNNTFTNAPVPFGAFPSLHAGCSTIEALFLSHFFPKGRVFYWSYVFWLYWSTMASGLHLYQISLYLTHHYLIDLVAGGSLACAYFYYYLARMPDELRHPTALVNGKFLHATPLDEELGMASTMLNGNGYGGWDSIDEEEEDMLDRFGASANPSTSSSTSSPNVNRTPGIGGVITPGGRSPNVNPNAGRKPSIVPNSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJ75</accession>
    <name>A0A2X0MJ75_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C029g10663 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C029g10663</name>
        <name evidence="2" type="ORF">BQ5605_C029G10663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ15344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJ75"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ15344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="66" mass="7410" checksum="B1E8843655E69415" modified="2018-09-12" version="1">MGEIDIECVLKKKERVNETRALDSIRVQATSESNQYATPPSASIRRRATRAPTSQCHKDTIPNPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJP6</accession>
    <name>A0A2X0MJP6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 subunit A</fullName>
            <shortName evidence="7">eIF3a</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 110 kDa subunit homolog</fullName>
            <shortName evidence="7">eIF3 p110</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Translation initiation factor eIF3, p110 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C002g01115</name>
        <name evidence="7" type="synonym">TIF32</name>
        <name evidence="10" type="ORF">BQ5605_C002G01115</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the eIF-3 subunit A family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY30084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJP6"/>
    <dbReference type="STRING" id="796604.A0A2X0MJP6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043614">
        <property type="term" value="C:multi-eIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.860:FF:000003">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.860">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.10">
        <property type="entry name" value="UVR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03000">
        <property type="entry name" value="eIF3a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027512">
        <property type="entry name" value="EIF3A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054711">
        <property type="entry name" value="eIF3a_PCI_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3, THETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22591">
        <property type="entry name" value="eIF3a_PCI_TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PCI" evidence="9">
        <location>
            <begin position="333"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="742"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="810"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="599"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="702"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="815"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="862"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="888"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="942"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="962"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1019"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1074"/>
            <end position="1087"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY30084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1087" mass="120255" checksum="C29E2E701B60C03A" modified="2018-09-12" version="1">MSPFTRPELVIRRCDELLSVNQPLAALSSISEVFSSKRFRTTPLSMLEPILIKFLGLCVDLRKGRTAKEGLHIYKNVAQNTSVSSVEVVITKFLEQSRAKLTEALAKVDELEGPAPEKSTAADGDKDDVEDLEASETPESILLSTVSEEKSRDRTYRTLVTPWLRFLWEAYRTALDTLRNNARLEVLYQTVCHDAFAFCLEHQRKTEFRRLAETLRSHLTSSQKYSHQSHSINLNDPDTLQRHLDTRFVQLNTAVELELWQEAFRTAEDIHALVGMSKRAPKASMMATFFDKMVKVFGVGQNYLFHAAAYSKLYALHAARVAAVGDKAEDAELEKLSSLVLLSALAVPLGSGLLGESGKRREVSEEGEAKGKLGRLAALLGLNAAPTRSGLLNDALSRHVLKRVSPELRELYNILEIDFHPLSITSKIEPILASLAAKPETARYVEPLKDVVLARLFEQLAQVYASLKIERVVKLASFAASEQVAATRMRVERFVTEACRRGDLDVTIDHATGSIKFDEDLFNADTSAAPIASTSAAPYEAKSLQPSAAALLRSHLARLAASLHATLDAVAPEHSPIFAATQAREKAFAAFAAQGADEREALIARAQIIKRRKELAEEQNARAEKEEAHQRTLRAAKKAEEDALRQKNEVRNRELERVRREVEQVKQAEAAKIAESLVKGGLKVDIDKLPELSASDLVQLQVQQIEKDKKDLAQKLAGVNKRLDYLERAFRKEEIPLVKQDYERQQTRDRLAHESARTQRAEQNKKQHAEALAIKQSLARLMPDYRAYKEKAERESRAAYEAEEKRLAQALAAAKAERRQQVLDQRRREQEEEQRREQEKAERAERERAAAEAQREEEEREAAEKAAIEARQRQMEEEAEAARAAALAERKAERDKDLETVRLRQQREEEALARRQNRQPSGPPPVGSAEWKAARAPPPVPVVAASSGAPSERPRLNLAPRTAPVPAANGGATPPVAAAASSPVVDRPSGPPRLVGVGGDKPSWREREAARAASGGAPTGPPTSATPPPQEQAASGPPQVGGGKWTRRATGEAPAEGAARQSSGSYRPPAARTDAPKDELRKSSGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKD9</accession>
    <name>A0A2X0MKD9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C021g09360 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C021g09360</name>
        <name evidence="7" type="ORF">BQ5605_C021G09360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000083">
        <property type="protein sequence ID" value="SGZ21369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MKD9"/>
    <dbReference type="STRING" id="796604.A0A2X0MKD9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008732">
        <property type="term" value="F:L-allo-threonine aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006545">
        <property type="term" value="P:glycine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000030">
        <property type="entry name" value="Low-specificity L-threonine aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023603">
        <property type="entry name" value="Low_specificity_L-TA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041359">
        <property type="entry name" value="GntG_guanitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="L-THREONINE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097">
        <property type="entry name" value="L-THREONINE ALDOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017617">
        <property type="entry name" value="Thr_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aromatic amino acid beta-eliminating lyase/threonine aldolase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR017617-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGZ21369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="407" mass="45286" checksum="88FC2B5A5CFD1BBA" modified="2018-09-12" version="1">MTQVSSKQANELKLKQISRDFRTDTITIPTDDMFDLMKEASRGDDVYGEDQATNDLQDRVAKLAGKEAGLFCVSGTMTNQLAIRSHLTQPPHSIILDARAHVHLYEAGGVAFHSQASSHAVPPANGHHLTLEEVLNNAVFGEDIHSAPTRLVALENTLSGMVFPQEEIVRISDKMRKEGIIMHCDGARMWEVVAKTGTSLEELCRPFDTVSLCMSKGLGAPIGSVLVGPKKFIERCKWFRKCFGGGIRQCGGLAACADWVLDNHLPKLKQTHEMASRLAQPLADLGVQLMLPVETNMLWLQPTSIGFTIQDLAERAKERHITLGSNRVVIHHQISPQALDDLVDLVREMKEEFKDAPKTPLDWEQNQRFAKGTYQGDIQPPIARLGTNYGESSRFRFFRFKNSCGID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKM1</accession>
    <name>A0A2X0MKM1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C033g11135 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C033g11135</name>
        <name evidence="2" type="ORF">BQ5605_C033G11135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000066">
        <property type="protein sequence ID" value="SGZ01278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MKM1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ01278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="330" mass="36236" checksum="1A5547E0F2A3F623" modified="2018-09-12" version="1">MSSTAAPPDARIQLLLDDVLEVPDEQFAAMSPVAELTVGELLAFEFTRPDLTATLAVSEFEPTFHRHQIRPNSTTRALFNKTHDLRELYATGYRSIEVRSPCTSIVEHMPIISEAFWQHLDSVEQLKSTISDNVDWLSNVEVNDKRDAAYIKLASALLCAISTQSRHQQGLTAVLRAPNPSDSSPTSCLDTYNSSVQTVEPPAGFGFDGHTRRVLDPQAQARYYQLQSFKGVLAASLAPIRKGLAHAGEERGINADGGSRADKRSGPSQGPSGRLWVASSERFFVFLAVGERFLGNFTTLNFSCFRNSSNRRANVHAYPSLALAPLLSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0ML16</accession>
    <name>A0A2X0ML16_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C022g09561 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C022g09561</name>
        <name evidence="7" type="ORF">BQ5605_C022G09561</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0ML16"/>
    <dbReference type="STRING" id="796604.A0A2X0ML16"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028258">
        <property type="entry name" value="Sec3-PIP2_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048628">
        <property type="entry name" value="Sec3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019160">
        <property type="entry name" value="Sec3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092:SF14">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092">
        <property type="entry name" value="SEC3/SYNTAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15277">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20654">
        <property type="entry name" value="Sec3_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09763">
        <property type="entry name" value="Sec3_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01313">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec3 PIP2-binding N-terminal" evidence="6">
        <location>
            <begin position="50"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="169"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="430"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="831"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="289"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="306"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="335"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="366"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="845"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGZ22925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1262" mass="138169" checksum="530BF4AB156041BC" modified="2018-09-12" version="1">MATQDHSRAIIGSLFTPPPGSSAPPNDSYVAYCPTWEVVPPVNAQPGQSPQVKARFLILSAARDGRLKLHKAKQNSNGTFSIGKTWPLEHLTQVEVAKRMVEGYPNPQPLEFVLTITGKAYRYKTNMPSSQQAAFLVTIVRCWRRFMNGRGQPDLVLLGFAVDNSQPSTFSASPHLGGAPPPSAMSPRTRTPSGPSPGHDFHRPGSSASSVPNAGGRRPPVQPNHAHVSPLPMSPVQAAMMMPPSNTSSPLVPGPAPNQGPRSRDLSIQSNYRIEAPPPPPIGNLQPPIQSSTSTPTFQNSFGGVALAPNARRPSSPSTSARPTLLSSPSPSASFSNGPTTIPIATNSSNLRRPTGQAPPMASSTNSLSVVNPSASASSSSSSSAAAAAATVAAAAAKSNSQKLEIRVRLGERKKSVVAAAQGLKISAVRANQPPGGMSGGELEPKSLPGTPPGLPGSSSTGLQFDGVGIGIGGTSAVKMPGTVGVGVKKLKTADEMVDDETVLMNVEEMLEGFEWRGAGIGISSGDGTSFASSSVRRHGVARADEIEKRLIGELKALEAASIHAIMESDDRVEDVVKCLDQTLAELEVMELTMGTYKTQLNVSQVTRTESSVGGFRLMTDDIAHIESQNRGLQVQTSNQRQLLFEIDKLMSTIHISEEDLAALAQESLESTSGIERLERAAVSLYKALLSTRDTEMLVASERVAEYRATATRFSKRVLDFLTIMFKFQVDGVLHPKDPKVKKEGRLPGHEQLEEFLGRYCGIMLFVKEIEFERYEEICSTYHSVMSDLYRSEIQELLASFKAQIRKTPEDELEAMHFAGKESPTLRQHSIRRPGTLVNRNPADGGRKREREDSAGSKEAKMSASEAFGRALEQIVPHVQREQGFLADFLHVNSLDASITFADYMMLETFFRRGATRHLNANFGKMKDIKGSMELVFKFLENELKEWIEGVLRMDPMQIVGIVAALDRFILQCEAERIEFLLRLFQRQHSKSISSLERQIKEQIKGIEQTKLTLKKRKGVVPFVRVFPIFVARLEAQLEGCDDLPIRDVVDGHYESVTSTMMDCLQQMAKMDGEGQGGEGKDQLNYHVILIENMHHIIAVFSEQQRVLALEPFVGQAKEKYTQNLDAYIRLILRRPLARALDFFTGLEQLLRTTPPNEVSLHSAYTKAAVRRALSDLRAKDVRKAVDGLYKRVDKHFGGEVTHQAAQHSEVLKTVWKACEDEMLRMSGGWRALLERCYSDDKVGLDFSATDVTEFFRKAQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLE8</accession>
    <name>A0A2X0MLE8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Ceramide very long chain fatty acid hydroxylase</fullName>
            <ecNumber evidence="18">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">BQ5605_C023g09716</name>
        <name evidence="23" type="ORF">BQ5605_C023G09716</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18 19">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="18 19">Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the sterol desaturase family. SCS7 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="18"/>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ24280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MLE8"/>
    <dbReference type="STRING" id="796604.A0A2X0MLE8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080132">
        <property type="term" value="F:fatty acid 2-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000007">
        <property type="entry name" value="Sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014430">
        <property type="entry name" value="Scs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863:SF1">
        <property type="entry name" value="FATTY ACID 2-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863">
        <property type="entry name" value="FATTY ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005149">
        <property type="entry name" value="IPC-B_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17 18" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="10 18" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 20" id="KW-0349">Heme</keyword>
    <keyword evidence="14 18 20" id="KW-0408">Iron</keyword>
    <keyword evidence="5 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 18 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 18 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11 19" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="22">
        <location>
            <begin position="18"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR005149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR005149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR005149-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="SGZ24280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="382" mass="44671" checksum="0F7663397A43691B" modified="2018-09-12" version="1">MSSMTGTSVTSAAPSRRTRIYLLEDVRKHRSSKDCWVVHDNKVYDVSLSVTAFLEDHPGGDDLILNYAGKDITSIMADPVEHEHSDSAYELLQQYQLGVIGAEERITNEDFVWNEKFEPQDTDTSQDWQKNQFLDLQRPLVMQMLRSDFSKSFYLQQVHQPRHMSEPATLFGPWYLEMLTRTSWYVVPIVWTPITLYFLHCAWMQQPVALDFSTRATRLGLSFLFGNFAWTILEYTLHRFLFHMEAVLPDHPFALTLHFLLHGIHHYLPMDRLRLVMPPILFAALSYPFIRLAHFIFPHNIAYGIIAGAYTFYIGYDLLHYFMHHAKLPRVLKAQKSWHMEHHYKEPNLGYGVTSPFWDMVFDTVFDAKARRMEGAKMNAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLK8</accession>
    <name>A0A2X0MLK8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C012g06809 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C012g06809</name>
        <name evidence="1" type="ORF">BQ5605_C012G06809</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MLK8"/>
    <dbReference type="STRING" id="796604.A0A2X0MLK8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY16223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="200" mass="22974" checksum="AA5BBD59E9AC40DB" modified="2018-09-12" version="1">MTRNRRRYDSTTRQDRRRQADLFAIARFRLHKLSLCLTYSGNSTNTTPELPTRRSRAAHWRSQLPQEDRVDPIELRKQLRLLLVDKFGEDFVPRPVQIEALAGLFQLERFKTRNQYDAVFVIAPKGSGKSLKFQAMYVVYGRRAVTIVVSPLTALSQHQVGFIRLAVEATPVLSPTVLIPLQADNLNQERKKAVVICKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MM13</accession>
    <name>A0A2X0MM13_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C024g09915 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C024g09915</name>
        <name evidence="1" type="ORF">BQ5605_C024G09915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ26439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MM13"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ26439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="72" mass="7253" checksum="7959C39B82277B82" modified="2018-09-12" version="1">MVAAAALVTSTGSSSTTTANAPTAATYLDDDMHNSFFSLGAIPWHTIDLVSCSSFTLARSVASALVPGGCQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MMU0</accession>
    <name>A0A2X0MMU0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C020g09056 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C020g09056</name>
        <name evidence="2" type="ORF">BQ5605_C020G09056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000082">
        <property type="protein sequence ID" value="SGZ16681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MMU0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032549">
        <property type="entry name" value="DUF4939"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16297">
        <property type="entry name" value="DUF4939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4939" evidence="1">
        <location>
            <begin position="54"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ16681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="236" mass="26268" checksum="F2CB09D70ADC2ACB" modified="2018-09-12" version="1">MSPKTISVEALQAALAERGAALAEVATLRAQGTVLQRSYEAIVENFNAVTKLTKHLQNTPKLKSPLEKLPTYDGKDKTAYTTFASQCKFYIYGNPSLFTTDQAKIAFMISLLRSNAYKVFEPYIELPEDKRPTFLKDFQAFLEQAQLYLGDPDREHTITNKLRALTQTGSAAAYTSTFIQLSVFLSWNDPALQAQLYAGLKPEVRNMLSVTSPLSARQRRLGRCARPLARPPALGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MMU1</accession>
    <name>A0A2X0MMU1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone deacetylase</fullName>
            <ecNumber evidence="3">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C028g10570</name>
        <name evidence="13" type="ORF">BQ5605_C028G10570</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone deacetylase family. HD type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="3"/>
    <dbReference type="EMBL" id="FQNC01000080">
        <property type="protein sequence ID" value="SGZ13445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MMU1"/>
    <dbReference type="STRING" id="796604.A0A2X0MMU1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019154">
        <property type="entry name" value="Arb2-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF5">
        <property type="entry name" value="HISTONE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09757">
        <property type="entry name" value="Arb2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="11">
        <location>
            <begin position="312"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Histone deacetylase" evidence="11">
        <location>
            <begin position="476"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Arb2-like" evidence="12">
        <location>
            <begin position="704"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="951"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="62"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="123"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="951"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="993"/>
            <end position="1006"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGZ13445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1070" mass="114925" checksum="86EB95B8749B455A" modified="2018-09-12" version="1">MSAPSVPDPLPTMDEAGPSQQPYTQAIPTPESFLTPASTTASTQRTGDETSLSAANTTNELSAPASSAFAASAPAESQQDTTMSSTTTSSSVDPAVESSSSFPVPSTSTDIVVDPPRLSTVGAPAAPFSSSLSSASAPPAAASQDALRSSTSDPAPTASSAVASTVDPVIITHSPDGSRAPVVAHVLGFAAVRAIANAHPNPQPYVEPPPYVAPTHVDSASTGIAKNSHPVRISLTEEEERMRPEQRHALQVAASRAVKAKTPEVMREEQVLSLDAKTLKKMGLGRTPSGYCYSSRMTMHQQLPAVARGELHPEQPARITGIYHKLNGTGFLGRMERIAVREALRDEVTLVHSQAHFDRVRALGFQTPEYLETCSEYFDRLSLYVNPDTALCARLSCGGVIEMCGAVAEGRIRNGFAIVRPPGHHAEPEDAMGFCFFNNVAVAAKWLRTIYDDGQSATSQVDGSPTIPSTTGATRVKKMNKILILDWDVHHGNGTQKAFWDDPNVLYMSLHRHDGAFYPGGTYGAAETVGDGPGKGFSVNVPFPHTGMGDADYIYAFQQIIMPIAYEFAPDFVLVSAGYDAAEGDELGQMKVTPAGFAHMTHLLSVLADGKLVLALEGGYNVESVVKSAHACVEVLVGDEPRRLELGAASQSATNVCHEVMKVQSKYWKSMGYALESPEEAKDAGRMIPLAGKTDCLSVEEEMLKSHRVYELYHDYAMYNIELADPELEEAYKDQVLCSSDVYDCETLIIFMHDIGSMKASFTAANLDIDLERTTLIDTSREVLDWAITDNNFGLIDVNFLAHTVTNKGTIIAPDLARDARLEKELALFVWDQIAGLSVATNIVLFSMGTGSRAMMHVLQNRQSVRERVRACIEILGLEHPPELGAESGIRGWFKEKSLVMLPSTHPLHEDSRKAGKHQKKYGNVFRSMPDDEGRPIHLLRASMGKVKEFVRDRLPVSTRPPKEKGSEEEGDEERGRAMEEEAGQNGSGTAIGGEATAPTTTTGDAMELETGKTEEVAAEVQEPKPVATTEEARTSSTSMAVDGIPGEASTQNGETGAVNGGADVTMGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MMW7</accession>
    <name>A0A2X0MMW7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C026g10220 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C026g10220</name>
        <name evidence="25" type="ORF">BQ5605_C026G10220</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ27916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MMW7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="380"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="125"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGZ27916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1046" mass="116382" checksum="C9E768E83AA4CCF6" modified="2018-09-12" version="1">MELSNAKYDEDENMGEFLKSMIDKADQLDDLGQKFGDEAMIAYILQALPPSYEMLKQAIRLGENRSVDHVINRLTDEYTERKLLGKFDKLLKNAGALAVQSTRASRDPNCVCRGCKGKGHFAMDPECPKYDAKKNHGRARNRNKKKKQDSKDSADSNELANSALTVKSLDESHSLQDNVANRVSQVNQGEIWILDTGASQHYVEDASLLSNRQSGNLKVQTASGQVVHCDTYGMVYFKLKSGASLSLANVYHLPGVPVNLISTRALFKSGAKCGWEDGNLKDVMTITYQGVILAKTLSGTGYALDFTRIVKDQAYVATRATVGAPLMEWHRCYGHVPVSSIMELVKSGAVEGLVLTDEKVHNCEPCISSKSCASKFSELATQVTDVLQRVFMDIGFVAEDQVDFQGRKAYLAIVDQYSTAKWTFPLKTKLAEEVTRVWITFQQGVEKMTGRKIKRVRTDNGTKFTNKLIGTDFQSQGILHETSAPYTPQQNGTVERFNGSLMAIVCAVLAASKLSWKYWSYALAYATFVANRILHAKLEGKTAYEVFYGKNPKVLHFCPFGSTVYAQVPKSKRSKLESTSVKGIFIGYDSEYNYRVLVDPDSDHKVIVGVPEVTTLPVGPDEEKGPVDNDDVVVDKLQDQVDDPAVKGRNPGRYEEIDANNEIPHRTRSQRRDAEQQVMYGSAMSVSLSPVPSNYKEAMASPEADKWIAAIKAELDAMARHQVLIDSDLPSGARALGSKWVFTRQENAQGEVTRYKARLVAQGFAQRPGIDYNETFAPVARPSTILSLVGTAAAQGLFLEQFDFDSAFLNGTMMEMVYMKYPKGWDRPQTGQALQWNAAVNSLMVERGYKRSAADSCLYVKRVDEKFIYITLYVDDGMVASNDQEFLDAEIEAFNKVYKLKRLGPVKLFLGLEFERTSDYIFVHQSKYIRDLVAMYGGGSVSKHPVKVPMEPRSDVKHSTDPFDDVALYQSAVGALQYAAHRARPDIVTSVRAAASKVSAPTQADWIAVKRIIRYLQGTVDWGLKFNHGGSTVFELYSDALWETTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MN98</accession>
    <name>A0A2X0MN98_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C014g07429 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C014g07429</name>
        <name evidence="2" type="ORF">BQ5605_C014G07429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY18655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MN98"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="529"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY18655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="659" mass="71885" checksum="140869C10F554E19" modified="2018-09-12" version="1">MSPSQKKKKKKKKKKKKKLQFHQKHDDLPACLVCGAPKDDWEHYFFDYVDSGNIWIAARSVLCNALGLDTIYNTHYTAVQRMFGLPKLKASLHNQEGAGRTIEIFTGLVLEMISSGRWGMQKWGTRTEGVGRRRIILEERLKLRAGGAWGRRGQRPWVPTAGTATSVQPPRDQIPVSSKKTQATGPATATPNYAAAASQVTQSPEQQQQQQQRAKALGSLLQAMGAVPGNRMDRWVQAIYFAKLYPVATATSLKSLALNANRSVENIFDYALEVTLSHQSASRASHADKTDLVACVTRLLLPISPICFEPGVPLPDHLAAYRPQILGVQHSSILRNGAAHHRVTVGFVTGKARDAALTTPPALTWRSAKARFAKSHRFHHNMDLSGKGHSCQLVQVLRIISVDNASAFAHVAGDYSAFLHFDDDSLFKRPNTTLKEILPSRIGLPTRGIPVTALRHDYEKEAACGRCHFVGHVGTCGLDQEVKRKEAHNANTNANKNTITNNTNIVEAEAPIPVPVVNRIASQNRFAGLEVEEGQEEAVTGQSGQGPEESGEEDAGDKADDEDSEDSEMASEATAKTEVIKLKSEDESVLEDCGGSDGEVVDEDEVMADGRGKTEGKVATEMEEREVATEMEEEEVATEVDDVDEAGGATKAENAEATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNP0</accession>
    <name>A0A2X0MNP0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">26S proteasome regulatory subunit RPN2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C021g09367</name>
        <name evidence="10" type="ORF">BQ5605_C021G09367</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 6">Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the proteasome subunit S1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000083">
        <property type="protein sequence ID" value="SGZ21435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MNP0"/>
    <dbReference type="STRING" id="796604.A0A2X0MNP0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000017">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016642">
        <property type="entry name" value="26S_Psome_Rpn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048570">
        <property type="entry name" value="PSMD1_RPN2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040623">
        <property type="entry name" value="RPN2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18004">
        <property type="entry name" value="RPN2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21505">
        <property type="entry name" value="RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015947">
        <property type="entry name" value="26S_Psome_Rpn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit 1/RPN2 N-terminal" evidence="9">
        <location>
            <begin position="4"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome regulatory subunit RPN2 C-terminal" evidence="8">
        <location>
            <begin position="785"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="835"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="995"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="861"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="909"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="995"/>
            <end position="1007"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGZ21435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1028" mass="109985" checksum="D5FB1743160E4473" modified="2018-09-12" version="1">MVQSAAGLLSLLDEPDATLQAYALQQIDPLIHTFWAEVADHVVKMQTPTFPSQALASLIASKVYYHLGNFDEALSFALGAGKWFNLEGAVDDQEPTEAEYIETIIAQAIDAYVDSRAAAATATTTASTSTSTAKPVDARLEAIVERMFERCERDGEFKQALGIALSSHRLDVIERIFVQTKNPELLEWILQIVVREGVISGSSRAYKTQVLNLLLRLFNSLPSPDYFSVTQCFVYLNDPSLASDLLSSLLCLSSTSTKVPSEEAILTAYQIAFDLAETATQEFLETVRNSLTTPTATAATASTDAAAPKEGKDLHRERVISILTGEETIKLYLEFLYRNNHADLLILKGTKDVLDGRQSVYHSAVTFMNAFANAGTTSDQFLRENLDWLQRASNWSKFSATAALGVIHKGNLAQGKAILEPYLPRAGTGSSSFYSEGGSLYALGLVHANHGGAETTTYLKDALKAGTQNEVIQHGAALGLGVSAMGSGNEEIYDELRNVLFNDSAIAGEASGYAMGLVMLGTASEKALDEMLQYAHETQHEKIIRGLAVGISFLMYGKEEEADGLIKTLLGDADPILRYGGIQTIAMAYAGTGNNRAIRKLLHVAVSDVNDDVRRAAVTSLGFLLFRNPTQVPRIVQLLSESYNPNVRYGAALALGISCAGTGLADAIELLEPLTKDPVDFVRQGACMSLAMILIQANETLNPKVAPVRKIYEKIVADKHEDAMAKLGAALAQGIIDAGGRNVTLSMQNKSGSSHMPAIVGMALFTQLWYWFPLAHCLSLAFTPTAIIAVDKDLRIPKCEFISQAKPSLYAYVAATKPPTKETVEKVATAVLSTTAKTTARAKAKESAQADEAMETDNAKPSTTTPAPATTSEGDKQPAATSKEEASTTATGEGADKSTTKLKRREPTSTRLQNLSRVTPPQLSTVTFPKEARYVPVRPVASLSETTGVASGVSSVGGGGGILLVRDQEPDKEAEFLEMQVMKVIDTSGAGAANTAGASAAGGAATTTEDHSGPIADPPAPFEWTDWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MP28</accession>
    <name>A0A2X0MP28_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C014g07699 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C014g07699</name>
        <name evidence="3" type="ORF">BQ5605_C014G07699</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY19604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="987"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="385"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY19604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1750" mass="192137" checksum="4488B53F33FD3FC6" modified="2018-09-12" version="1">MHDASTPPSQAPLLARAAQRAVRNDAAPASNVIRVIMDGPGSPRGPVQIALRKHFGLAETPFMFARPEGVVLDPEVEKLFSKCVKLNPIVTKATKRFPIARHMYELVFESDQACLEAAAAGPFSHHGKEMVTELPSASPLNHVVQVRFTLPSSSSATPASVLRQSLDDALTLSFGRAGRTQGYTLMQLQRGLAVDPNGDPMAMTEDGFHCAYLRLHADLFQGSTETQKAALNAALPQEIEILGAKYGLRHEFETHYCAVCDRAGHQWGACRKPVSTPATAAPVPGATTSTPTSTTGFRVAGKNGKHGGPAALNSRASGTNMIQLGPRANPAGAATGNKDDANDDDGDDDDDGGGESVASTEPEGGDTGKETLTRATMGPTKETQTTTAAPVSTPTSPSPSASAPASPLSGGTSESSATSTTSIASTSPRRLRSSSAPGNRRVTRAGSAMILGASGGDGSGGNSSGVNQVKIIRYLKTLRPAPAAILLQEHHLSYNASREGFESAWPGACIRFTPHVLTLIPDGSPLAGHLLSSTPVVFAGAPRLDGRILRSVFRLEELDVEIINMYAPVQEDDRRDFFGLLHFNAPRPKTLRILAGDLNDCPDVSVDRVSITDRAWTPVSHWQTLLSKIAFNALDTVRHVHSCTPAFTRPHYRGRGEERKICSWSRIDYILVQCSWANRLLSASTLFDAPCSDHRPVVATFALPTSNADAEPPLSLPSTSDFISRLNPTVFDDQDFVASIPGVVDEVYRRLEGTAPLGDVYDAALRAVAAAGHARYRSTRADMRRLRAENQSVMEALEARGEHMNEAERDAYALAKSQLDQLAVKEAQWLRIRAHVPSVDSREGQSASIRTRLNRRSRQTSIVSLEDVDSTETVDMQEALGIASRHAQSLFTPDPARGDPTNARRSLLDPIRAAKCYDDDRSDPTFGRRLPRQARVALDEPFNLSEVEAALKKTDSGRSPGPSGIPYELFKALPTYFAPKLLDLFNSIWEGGKMTASLAEGLVRLLPKNKPGANLKSLGAYRPITLRETTYKVLSKVLVARLNGVLGELLPPAQHGFMPSRRSADAGSHLTLLLEKLKSLGTEVFPEGALLSLDQQSAYDRVDHAWIFDVFEAFGFGERFISLLRALYDPETLGVRYLINGFPTELVRLLCGLGQGDPLSCPVWNITFQPFLDALVRRGIALDLQKVWPGGPRAQLTHLAFADDAVVVVESPAALSKLETLSHTWYEATNGKTNTDKTLVLPLGPNWLRDETAQALPTVQEGESFKWCGYAFFRHGDSKLFWTHVLDRIKAKTRAAGDRTLSPSGKVFYANAHIISTVLHVLSFDIPPQWFIKAAETALTDFVWGGAGRNTVARDFVFQAREDGGLGLISIGDIVHSVALRFWDAVAGSNEAIWAPLARESWRSLVAATRDFSPWGFFSSTARVEKLYRDSTRWGAVVAAARVTVPTIKSELLTLPELLSLPPRLPSLYAEGAKHAYDDADAVAKFAQIADLYWRDEGKGWALVGHRRGFWQHSKEPALQHEHVWSRVGQLLKAKALLPKTALRPARIPLKEAPRPRCFNFFGLTRPFTIRKLRRLVNVVRFPGREDRVKRFRDGTSQSDRKRFWRWLHDRFASAVEQDTHWRLMYNVTPTRKRQHTQGHASSPTCLFCGNDAAVIETVSHYFFECAYSTSFWGGVLRILFDKLGIEDTDVDPSTFTPEQLTMGLPLLRGRGRTTSRWMWVRLACAIGFQRLHLLRWRVHQRFELDVVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQY2</accession>
    <name>A0A2X0MQY2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00502 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00502</name>
        <name evidence="2" type="ORF">BQ5605_C001G00502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY47167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQY2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY47167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="173" mass="19784" checksum="3C93DE15A23E6AAB" modified="2018-09-12" version="1">MVSNRARYLRVSVLMTEAKRRTKTATMRMKTARKGTKRMVMANDEGQVKGSRWRVSRSPFFAHYLPNATSTSQSRIAPNVPSWKPTPHHDPRHQRLDPEPNRDITQRYQDAMACVVKEEKPPLLITMTYDSDSPEIKAALGPIKHATRHAGCFGNECKMNGFCFFAVFRIVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MR46</accession>
    <name>A0A2X0MR46_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C025g10064 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C025g10064</name>
        <name evidence="5" type="ORF">BQ5605_C025G10064</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000087">
        <property type="protein sequence ID" value="SGZ27141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MR46"/>
    <dbReference type="STRING" id="796604.A0A2X0MR46"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF6">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGZ27141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="240" mass="25556" checksum="C4FF6450DB2C3984" modified="2018-09-12" version="1">MQGLSQGIIPVELDVNSPSRPASPRSFGKRARLLPTDVCINNAGQGCVAPLIEVDPAELRKTFDVNVFGLLTMVQAGAPHVVEQRSGTIVNIGSIVAYVPTPWAGVYCATKAAVHSLSDTLRMELRGFGIKVVCVAPGAIKSAIGASNDKRAVLSLASVYSNVESFVRLRGSWSQRSKLIPKVAQAKQELHDSDLSMTRKLLTRVTLRVGNTPRSRALLGADEVSVVALRSDVNASNTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MS50</accession>
    <name>A0A2X0MS50_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C058g12705 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C058g12705</name>
        <name evidence="2" type="ORF">BQ5605_C058G12705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000091">
        <property type="protein sequence ID" value="SGZ29126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MS50"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ29126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="493" mass="52686" checksum="29E4A8327867096E" modified="2018-09-12" version="1">MVVTAWIGKKARSFYWIVFCRLPTAQQPALETQPRRDIRRCRGQHEQAMPDPPGAQAPPPDNPLGGNRASDDESLNTLTREPVTGGTANPPAWSTEATQARLDCEKVMQNTFRVLGIVPSGKSTRRLMVLMHDASTPPSQAPLLARAAQRAVRNDAAPASNVIRVIMDGPGSPRGPVQIALRKHFGLAETPFMFARPEGVVLDPEVEKLFSKCVKLNPIVTKATKRFPIARHMYELVFESDQACLEAAAAGPFSHHGKEMVTELPSASPLNHVVQVRFTLPSSSSATPASVLRQSLDDALTLSFGRAGRTQGYTLMQLQRGLAVDPNGDPMAMTEDGFHCAYLRLHADLFQGSTETQKAALNAALPQEIEILGAKYGLRHEFETHYCAVCDRAGHQWGACRKPVSTPATAAPVPGASTSTSTTGFRVAGKNGKHGGPAALNSRASGTNMIQLGPRANPAGAATGNKDDANDDDGGGESVASTEPEAATLGKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MT66</accession>
    <name>A0A2X0MT66_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C046g12252 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C046g12252</name>
        <name evidence="3" type="ORF">BQ5605_C046G12252</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000112">
        <property type="protein sequence ID" value="SGZ30873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MT66"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1083"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ30873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1213" mass="135770" checksum="5247454C90B9DB0A" modified="2018-09-12" version="1">MATQSPEQQHAKALGSLLQAMGAVPGNRMDHWVQAIYFAELYPNIFDYPLEVTLSHQSASQASHADKTDLVACIMRLLSPISPICFEPGVPLPDHLAAYRPQILGVQHSSILRNGAAHHRVTVGFITGKACDAALTTPPTLTWQSAKAHFAKSHRFHHNMVELRISVGVQGVPSMDAIIKSFQSLVQDLSGKGHSCQLVQVLRIISVDNALAFAHVAGDYSAFLHFDDDSLCHFVGHVGTCGLDQERKRKEAHKGNSNSNTNTITNNINIVEAEVPIPVPVVNGIASQNRFTGLEVEEGQEEAATGQSGQGPEELGEEDAGDKADDEDSEATAKTEVIKIESKDESVSEDRRGSDGEVMADGRGETEGKVATDMEEEEVATEVDDVDKAGGATKAENAEATDLGETNRLDNDDDSDATATAATASRELTPHEPTPPLSPKTLAKSLREGEEWDRIRANWVAQARLERDQSIERRLDAETPLVRHNFATWDEDGEIRSINIRGTASKFKKPVMKRLQTAADLSDPSDEPTDAKRVIIKGKSRVVVKDGTEGRRLTRSMSAAAAMPVGLTKVDRGKAKRVAEEKRWSDHEPEDDRFDLNYPLMIKHTIITWNVRRGMGVPEKRRDIYNYLSLFKASAILIQEHFIRPHLWQLIKDEYEGKLFINQHCLTLIPADSPLIDAELLRTHSALDGRLLVTSFCLRGDIKILEINNVYAPVDPKQRAKFFDKLLFHKTQKSHLRLLGGDLNDCPHPEVDRRNQTSTIYDYPKELSNHRPVLIVLALSDDLDATLPQLSLPTTSNQLHQINTTTFKTVEFQQMMEEWLEGASGEEPVGELEVILKACRDRGGEMARRLHWERTERMEYLVGRVQDLQAIPEWGEAETAEWTRMSKELKRAVEEHTRLLRIRAHVPEIASEERLLRPIHAKLAARNSDSKITALRLSNGELMHDIDVALDHTQAHFQRLYHIEPRDPDRIDQLWDKFLAPIRAARTCDDPRSDPLILHQLSESQIDLLQRPITKDKVVAAIGTTHPGQLPGPSGVPYKLYQIAPKAWAKVLTKAYNAMIERGSLSPKQGQGLVRLIFKRHKKNADRAELSLYRPITLRECDYKIFTKVYVARLNQILPDLLPPQQHQFVKDRQSADAALHLRLLIKELGAHRTEFPAATLLSLDQLSAYNLVEHDWIFAIFDALGAPAVEWMPKRFWTWDVATAEATGGVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MTB4</accession>
    <name>A0A2X0MTB4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g04168 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g04168</name>
        <name evidence="1" type="ORF">BQ5605_C006G04168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY56760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MTB4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY56760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="63" mass="7311" checksum="E2B2152F58DD5559" modified="2018-09-12" version="1">MLQSWTEVKRNGTCALSISNRPNPSQPLNSSDYRRWLVLSDLFKREHRETRLEAKANGPKVMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MU10</accession>
    <name>A0A2X0MU10_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C007g04399 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C007g04399</name>
        <name evidence="2" type="ORF">BQ5605_C007G04399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY60254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MU10"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF463">
        <property type="entry name" value="REVERSE TRANSCRIPTASE TY1_COPIA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="64"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY60254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="556" mass="62324" checksum="C3316657899FB5A3" modified="2018-09-12" version="1">MVDVLDTPPMFHDKLSYNAYCAAVFAEEDIEIPKTFEEAMKSPYRNHWSAAMVSELLQFDHHGVFQEVKWHEGIRVLGTIWVYSIKRDANGKIIRFKARIVAQGFAQRPGIDYHDTYAPVARSSTILFLIALAAAQGLYLEQFDFDCAFLNGKMTEDVYVRYPKGWNRPQSPGKCLKLVGSMYGTKQAPREWYRAVNDLMVSRGYMRATADACLYIKHSGTSFAIITLYVDDGLIASNNQSFLDSELGSLHKAFQLKRLGPVSYFLGFEIHRTKDYILVHQSKYVRTMLEKFDFASPSKRRAVTPMDDRPSLRIDATPFADVSLYQSAVGSLQYASTRCRPDIAIAVRAVAQKNSCPTVDDWAAVKRIFRYLNSTIDLGILYRNNSTTRLMVYSDASFADDPESRRSLGAYASMLAGGVISWQSKQQSMIATSTTEAEILSASSATREAIWLRRLAGDVGIPQAQPTIIQEDNAACIQIAKDPVNHMRTKHFDIAHLFVRERVASGEVELEYCPTHVNAADIMTKPLGFQRFDQLRALLGMVSLVSLTGGSVRSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MU49</accession>
    <name>A0A2X0MU49_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C007g04439 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C007g04439</name>
        <name evidence="2" type="ORF">BQ5605_C007G04439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY60481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MU49"/>
    <dbReference type="STRING" id="796604.A0A2X0MU49"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016013229" evidence="1">
        <location>
            <begin position="36"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY60481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="451" mass="47888" checksum="0D0E6886008E9861" modified="2018-09-12" version="1">MTNSAVRAATATSMSSLLSVAVTLLAVSQSAFVDAMRIPPQAPSSSLFARDFPIKRSPRVIPCTGTMRIDENIIQCPAGLYPSADGRCEQSFADTSTMWRTLAHAGILFQSTGRRCIACQDPYAITCTSSEAVTCKSGIAPKDGYCLTSWDCNGAPPRYLAPDNVSCYPCPSQNATSCDRNGGSTGCSYGVPENGACVAVKCPTSSVITDGNGCCPDPYAITCNSGGSLSCKYGTPSDGRCPKPADCSGSPPRYPSKDSESGLSCLDCPTNSTSCDDQGQATACSYGDVSGGQCKEVMCPTGPVSVHGSSCCSNFTLTCEDTNNSLICDKGYKVSGTMNGTIACQGPYSSRYGRGTFMYGARPSPFNFWPRTSVETCAIEARRRNTTYMWTANTGRGQCLFIPIDGFAVDVKSWTNKRWYDFGIFGTCDETTRDWSVGSEHAGECEDLLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MUK4</accession>
    <name>A0A2X0MUK4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA-binding protein VTS1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">RNA-binding protein vts1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">BQ5605_C064g12788</name>
        <name evidence="15" type="ORF">BQ5605_C064G12788</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">RNA-binding protein involved in post-transcriptional regulation through transcript degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer. Binds to RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000132">
        <property type="protein sequence ID" value="SGZ35160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MUK4"/>
    <dbReference type="STRING" id="796604.A0A2X0MUK4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09556">
        <property type="entry name" value="SAM_VTS1_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000033">
        <property type="entry name" value="Protein vts1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050897">
        <property type="entry name" value="SMAUG/VTS1_RNA-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057327">
        <property type="entry name" value="Vts1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037635">
        <property type="entry name" value="VTS1_SAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515:SF5">
        <property type="entry name" value="PROTEIN SMAUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25479">
        <property type="entry name" value="Vts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SAM" evidence="14">
        <location>
            <begin position="747"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="84"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="265"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="322"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="533"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="693"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="809"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="378"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="440"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="707"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="823"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="837"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SGZ35160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="862" mass="89764" checksum="4FA8879C1D16CBDA" modified="2018-09-12" version="1">MSAAASERVAAAGHGGAPRHHSLSATMSGAIQQSQQQAQQQQQQQQQQQQQHTSGLASLPSRPPPSADPARARGSIDAVGMRATFSSHTSGGPHSHASLVSSSTPNSAGGGNWNRARPASDFLSASHAASMHQPPNLTSVESIDRWFEDLQHYETTLEEMAAASLDSNFKEELSAIEQWFRVLSEAERTAALYSLLQSSTQVQMRFFITVLQQMARADPVTSLLSPANPNQQSMETQMEAKIASLGLKGSTSPVVRQFARQSLGDSYLSPHSASNPSASVPGPPSPTAANSDDPTAAATLANQRAKLKATARTSAPANLLLSAGHDANKSTSSLWSEKETLLERRSPSPGDRPRSTGSEHLSANVANPNGAHSGLHLSHSTGPPTTASFPRSSGVESDIPQLSPLVGGSWASMVNTPLVPMFGKAGIEPGSQMEPGNYGGNSPSIGTNTWSSGGVHNGSVSPVLLDNDVRKFRRSARIGGGGAGGSPSGTAISDGALSGMYDDRVGLRSPAGTGASQFSSMQQNAINLGLAGLQQAQQQQHHHHSSPGLGSSRLNSSGALNSPGLIAAQQAAVAAQQNWRNGLGVTNAGLGVGADTGFSPSLGSTEFGMGGGGGGGQASTNAQLANLLALQQQMIQQQQQMQVLSNLAAGGMGLSPVQMMHFQQQQQALLSPGGRNYVPTSLMGFGNAGLGMNGINQARRSPRVDRSPGTPSCPPSKTSTPNPGASATVAGSGANPDEPLDMSLLSDVPLWLRSLRLHKYTSTFENSNWKEMVMLDDEGLEKKGVAALGARRKLLKVFETVRLKTNMALPGDGAMKADDRTATRSVSPNTADGTSPDPDHGNNKNGEWDRLSPAPNSAKRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MUP6</accession>
    <name>A0A2X0MUP6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C007g04629 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C007g04629</name>
        <name evidence="1" type="ORF">BQ5605_C007G04629</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY61950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MUP6"/>
    <dbReference type="STRING" id="796604.A0A2X0MUP6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.240:FF:000001">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901">
        <property type="entry name" value="2-DEOXYGLUCOSE-6-PHOSPHATE PHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901:SF38">
        <property type="entry name" value="PSEUDOURIDINE-5'-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY61950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="242" mass="26601" checksum="2E0B72C4104723B6" modified="2018-09-12" version="1">MSSPPLPQIKGILFDMDGLLIDSERIYTQVSNQVLAPYGKEMTWEIKAGIMGRPALDAATYLVKATGIELEPQVLLELMDAKVQEAFAKVQPLPGAVKLVQHLEKHGVPIAASYYPPASTSPFPKNMAIKSTHLPDLFNLFGTRIMVGDDPCLQGKGKPDPTIFIEAAKRHLDFDCDESRSRVLVFEDGVPGVRAARSAGMPVVWVPDPELLKTMGDHDLDPTQILNSLLDFVPEEWGLPPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MV08</accession>
    <name>A0A2X0MV08_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g01969 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C003g01969</name>
        <name evidence="1" type="ORF">BQ5605_C003G01969</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY38159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MV08"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY38159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="302" mass="33693" checksum="B703E975F1C3E783" modified="2018-09-12" version="1">MRDSKTGAAIVHQPHFISSILEDHNMAGCSPRPTPVSLYKSHSRKDLAFDASTKPYRVIVGKLLFLSGTTRPDIAFAVSKVALHCNNFSQNDWEALMHILCYLQGTRDVGLLFRKSEGSPLLNGFVNANHGADLETRCSVTGFVFLCAGGAVSWMSKRWALVTVSSTKAEYVAMLFATRKGIWLCRLLSELGFPQMEPTRLHGDNQSVIWLAKHSAFHARTKHIGIHFHFIRDHIAGGTIEMVWIPTNTMATDVLTKGLGSRKHWDFVHTMGLVDATREGGSWKERQEVEEVCAAYARVNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MYS8</accession>
    <name>A0A2X0MYS8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00774 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00774</name>
        <name evidence="2" type="ORF">BQ5605_C001G00774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY49374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MYS8"/>
    <dbReference type="STRING" id="796604.A0A2X0MYS8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039254">
        <property type="entry name" value="Rds1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38705">
        <property type="entry name" value="PROTEIN RDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38705:SF1">
        <property type="entry name" value="PROTEIN RDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13668">
        <property type="entry name" value="Ferritin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016166018" evidence="1">
        <location>
            <begin position="21"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY49374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="333" mass="35864" checksum="CCD9F3E1649A9C8A" modified="2018-09-12" version="1">MRSVLALAVMALAAIAPVTASTERMAQITKRASGPTDVEILNYVFNEGRHADARRASRDKDIIITLAFVEFSHEALTLEHLEKNFYFQGLDKFRPEDFKKAGFSPEVFKNIQKIAIQEKDHVKFLAGALGSAGVSQCKYDFKVAFTNVYTFVATARILESVGTAAYLGAAPDISSKAYLAAAGSILTIEARHTAILNTFSGDSGFPVAFETSLDYAQVYSLAAGFIKPKTCGKNGALPSSIQRFPSLSIENTPRAGHTTEVQFNYRGDKKTGFYAAFLNGGATIIEPVKHGKDGKDRVDIPKGLEGITYIVITTSSKTLSDSNTVAGPATAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MZ45</accession>
    <name>A0A2X0MZ45_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C008g05105 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C008g05105</name>
        <name evidence="8" type="ORF">BQ5605_C008G05105</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MZ45"/>
    <dbReference type="STRING" id="796604.A0A2X0MZ45"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF8">
        <property type="entry name" value="NAD-DEPENDENT HISTONE DEACETYLASE HST3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="7">
        <location>
            <begin position="17"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="65"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="149"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="468"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="468"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="596"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY79316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="607" mass="66182" checksum="24DDBD22C200D807" modified="2018-09-12" version="1">MAPASKTPPTTQDVYLDCECDAALDKMTAAIAKAKRVVVAVGAGISTSAGVPDFRTKTSGLYARAGNGNAAGGDDHQPDDGRARRAATGTATSPTKTASKATTKRADSNLLKGPAMFTSSVYTAVSTRTAHWQFMTRLKRSVDHIASASIPPKLTSSSTALPSSPSRSTRASAEKREKGVTKTHAFFDTLHRRGQLGRVYTQNIDGFELTSGQLEGVGIEGIRVQADHVDYSERSSKPKGKGKAKAQEWTGDVVQLHGSLGRVKCSSCAWVGEWDERHSNAFEKGMSVDCPACVSQAELRVCGGKRALVLRSFVRPSIVLYGERSPAEQSIGSIITCDLSRKPDLLIVMGTTLKIPGFKRLVVDMSREVRKNGGLAIFVNREKNAAAMWKKVFDYQGTLGSRSQVIIGVIELIRLDPSTRTVIGSTDDFVDRLLKRWKQTRPADWQKQATLNDTFTVAKPSQVVVSKPVQPVPPITSSSSSTRTPWRDPNFSLGVPGPGTPPSSPLKRRSSCSDRTNLPSMDKLPETPSKRRSPRKPRTEQEQEQGPAFDFDYDHLDQLSKTRYPRMDQISDPPSTPFRMPVLCVPKSPPTPTRKVLPRSPRRAVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MZ97</accession>
    <name>A0A2X0MZ97_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C008g05155 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C008g05155</name>
        <name evidence="4" type="ORF">BQ5605_C008G05155</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MZ97"/>
    <dbReference type="STRING" id="796604.A0A2X0MZ97"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032093">
        <property type="entry name" value="PhoD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052900">
        <property type="entry name" value="Phospholipid_Metab_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606:SF7">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16655">
        <property type="entry name" value="PhoD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015926460" evidence="1">
        <location>
            <begin position="17"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase D N-terminal" evidence="3">
        <location>
            <begin position="70"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase metallophosphatase" evidence="2">
        <location>
            <begin position="187"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY79527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="599" mass="66706" checksum="FF636BE7D5DB06F1" modified="2018-09-12" version="1">MLALISLLALISGACALPNAQAAVPAALQSNLAYRSPSLNVRALEIDTGAVFSRKRWANTFSGNLSFPFGVASGDPYSDSAVLWTMPRKVDPEGLYGGNAYPPICLLWVVAPTNSSFKIEDSVQHGYVQTTIDIDFSVKVIADNLKPYTKYYYRFESCEDEPDLGVSPVGSFKTLPAENADVEKLRLAVFSCANYPFGFFNAYGAAASNSDRLDYVQHIGDYIYEYANGAYGDGTALNRIPQPLRECSSLQDYRDRYATYRSDPDLQKLHQLLAWQTVWDDHEVADNTWAHGSADSNDTVQGQIGLNQFSARKANAVRAYFEWMPIRQVETDDKLRIWRTFKLGKLATMIMLDTRQYDRSLTDLYYNTKQVAAVADSSSRSMTGSKQQAWFFDQLKQHQERKATWPLIMQQVVFSRVNYTISTEGSTDFNFDAWEGYRYQREQILQFIKKQKIENTVVLSGDSHASWVFDLVETNSTTYNPATGEGALGVEFAGSAVSSPSSYGHGPSFTDEVYKGIAKGLTLASPSLLYAEGKLRGYFELLVTPKAVQAHYYGFVDQATRNYNVTEMGVFETLLGANRITRPVNSGTVPVYGALGAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MZN0</accession>
    <name>A0A2X0MZN0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C008g05275 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C008g05275</name>
        <name evidence="8" type="ORF">BQ5605_C008G05275</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MZN0"/>
    <dbReference type="STRING" id="796604.A0A2X0MZN0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF60">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="488"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="531"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="563"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="591"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="619"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="213"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="46"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="46"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY79992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="668" mass="71621" checksum="3F0B40C8BA7402D2" modified="2018-09-12" version="1">MTNTPTLIDSEPLSLTESHLSIEATRASLQPSQSRAGRVLPSFQAMSSSPCAAAAYAHGAPATAPGGTSGARTSTTGSEPRRPSTAPSIDSHDTLVHESDNLVNSARDPKDADAPSSSDRRVSSDSARTVKLKPDEDLEKGKVGAIVGEPVEKPPLTDDGRVITVVDWEGPDDPAFPLLSAGGCSERALAVPDPDGDGSLCSKNWSNKRRMGATMIVASFTFLSPMSSTMIAPATGQIAEKFGVTSTVEIASFTSIFVAAYALGPLFLGPASELYGRVPVLQSANLIYLLFNLVCAFAKTPTQLLVFRFLAGLGGSAPLGIGAGVLGDLWRPEERGRAASMYSLGPLLGPAVGPIAGAWIAEKSRWEWVFWSTTILCVVIQGFGLVYLRETYPPQILRDKASKIKKERGLPTDSLEVQTIFEIKSGGSGKPVNVFRHSMVMPFKLFWSEHILQLLAVFAAFIYGLIYITTVTTTDIFTQVYGESVGIAGLNFISQGLGFLIWAQTQGRVLDVVYRKFKERYGGEGKPEYRLPMMAFAVTLLPLGLLFYGWGAEHRLHWIVPNIGLGFIAAGMISAFQCINMYLIDAFTLHAASAVAAATCLRSLCGFGFPLFAPSLFKALGYGWGCTLLAVVGIVIGWPAVPILFFYGERIRASSKYAAKSKVNPNYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N458</accession>
    <name>A0A2X0N458_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C030g10831 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C030g10831</name>
        <name evidence="2" type="ORF">BQ5605_C030G10831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000069">
        <property type="protein sequence ID" value="SGZ08986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N458"/>
    <dbReference type="STRING" id="796604.A0A2X0N458"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="1">
        <location>
            <begin position="101"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ08986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="200" mass="22042" checksum="50CEDFA845282DDC" modified="2018-09-12" version="1">MASNQTFLFAGLPKLGCQSPETESRSTMVSNRARYLPVSVLMTKAKRTKRVVMANDESQVKGSRWRVSRSQFFAHSLPNATSTSQSRIAPNVPSWSINGLTPNQIGRSMTLGSTFKNRPRDITQRYQDAMACVLKHGKPPLLITMTYDPEAPEIKAALGPNDKACNRTDLIAQVFEAKPGNKRHAGCFGDECISFLCCTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N616</accession>
    <name>A0A2X0N616_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C008g05087 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C008g05087</name>
        <name evidence="7" type="ORF">BQ5605_C008G05087</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UTP11 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N616"/>
    <dbReference type="STRING" id="796604.A0A2X0N616"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007144">
        <property type="entry name" value="SSU_processome_Utp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03998">
        <property type="entry name" value="Utp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="192"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="288"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY79253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="326" mass="37112" checksum="45A043150D13CBC0" modified="2018-09-12" version="1">MVAWKLNEQKRQHRERAQPLHRAKLGLLEKHADYVKRARDFHSKEDRLTKLREKASAKNKDEFYFGMIRSKTLKGVHVQSRGNEAMSNDLVKVLKTQDAGYIRTQQAMEQGRVRRLQQQLDSLVDNVTNAPPKPTTGADDHDEMMRDLDDWDAFDSVPPVASTSSLGAASGPKKHIIFSDDLDKVRTVDDPSKILPKKRRTPSTSTMTKSASSKKGKGKAPTTEFGPTPEELEAMNKATQAHRERLTLELDARQERLRQFALALKELENQRLLMGKGAKKMIVKKKKDPSARVEEDWKGDKTTMDEEEVGIASGARLYKWKAQRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N7Y0</accession>
    <name>A0A2X0N7Y0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C009g05808 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C009g05808</name>
        <name evidence="2" type="ORF">BQ5605_C009G05808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY86270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N7Y0"/>
    <dbReference type="STRING" id="796604.A0A2X0N7Y0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47381">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47381:SF3">
        <property type="entry name" value="ALPHA_BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY86270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="318" mass="34882" checksum="8E9176382704B4AB" modified="2018-09-12" version="1">MSTEQLPNPKTFHIGGIAAHVYGLSSPLLRNTSSGVPDTAEGVTVLFFLHGRFGHSLEPRYVKPIQSFLEAAERAGKKLVVIAFDQRNHGQRTVDKDRNKGWKDDGTKGGELNNESHAGDMMAIQLGTARDVSLLIDFAEISVWPRGEQRVVQWWCAGVSLGGHSTWLALAHGTFVHLTEPRITLGIPIVGSPDMLTLLTARARSLDLAIEAPHFPSRLLELWQRLDPIHAPPKAYEGKKIIVLSGAEDELVNFVKGGTDDFVSSKLTKAVGKNGCVQVWVQEKTGHTYSQEMIERTCRFLVETGWDLSAAAQGQSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N8U9</accession>
    <name>A0A2X0N8U9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C026g10129 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C026g10129</name>
        <name evidence="7" type="ORF">BQ5605_C026G10129</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ27574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N8U9"/>
    <dbReference type="STRING" id="796604.A0A2X0N8U9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38483">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38483:SF1">
        <property type="entry name" value="ION TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGZ27574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="251" mass="27719" checksum="0466964AE78B4E87" modified="2018-09-12" version="1">MSAPSPLISPSQTPPPPGAQDHGVRFSTPPLRSPHFVSRAEAIKGLSNRFVFSWFYIYLYLAMAFLSLTTVVLSVLSDCPTFTFYMLEIIINTTMIVEVSIRLVAFGKQFWKSYYNTLDLIITILCMITLVVIFFSGCSAKGEEVFDVFLLVVRNLFQFGRLALVMRKSGKNAFTRPAPIDLSSARNYSFSLDLDLDDEEALSTERRALGGDLEAARVSRTIGAGLQGRKGAAAGGGEDRPFTLDDSDEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NA90</accession>
    <name>A0A2X0NA90_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C056g12668 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C056g12668</name>
        <name evidence="5" type="ORF">BQ5605_C056G12668</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000095">
        <property type="protein sequence ID" value="SGZ29465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="508"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="755"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="775"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGZ29465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1420" mass="154438" checksum="2E23B92F34495D65" modified="2018-09-12" version="1">MPPKSAPGATPQPGTSLEAAIAPIVARPPQQPASFAATELLRDSAGYQDWLLVVRSRLPAGVLRYLESGEPCTSWPPSLVPLWDHYALSSLCSSVDPRLVLPGLSTFLDDSDGAPKIWQALRSRYGATSAVDLLPAVVTLFSTEELPATTDSFLQFRDGFEIQLRLLTSSKVTVDSLVASHLLSRLPPSLESWRSTFVNDQGDSTTLPSVSAIFDRLLRDIRARPVDAPTAALARSSARDTRAPRTPCPNPKCRKMHWLRDCPDTAWAASFRARRAIENSNKPAGERKPSQPAASPAAAPSVADEHLSPAIYSACFLSASSPFDKGAWLLDSGANRHMANDVRLFTHLQPVKGPHVAGVAGSLPSTGSGSVALDTTSGRIAVADVLHVPSLPCNLLSVRRLDRLGFTVSFGSNVATIRNAAGTAVATARAIANDLYTLDLTPAPCRPHALLASPSHVSLLTLHNRLAHLPVLLLKKIVQKGMVTGVAWDYSDEECRTFHCNACLASKAHALPFARSTSIASQRLGLIHVDLAQMPHVSFGGHRYMLVIVDDHTRKHWCILLARKSDTFPRLRDWILEVERATGDSVKTIRSDNGGEFTLRSFVDFCCSKGIRRELTIPYTPQQNGRVERPNRTIKEGILALAYSAGVDSRLWGEAAMYFVRCKNMTPHAGINGDIPDARWYGYAPDISSLRTFGCRAWHCLPSPSRSALDPKAIPLIFVGLDDHSKAYRLFHPTTRKVLLSRNVLFRESEFPASTPTPALFSPANPLPDVVASRPDPPQPLLPAPPRSPVPRAEQLIPAPDASDQGSPALARNVPDQALPAPFASDQGGAPDQGSPDSAFSTPCPSPRLRPSSYDFSALCLAPEFSDDVDDALHSPAPVCYLADAAAALLDTSTVDPAELVAPARDPPHWRAAMASPQADEWRLAARDEFDSLSRDFSAFTPIDQSLVPADAKIIGSRFVFRTKRDQFGKVKSYKGRLVARGDSQRSGIDFDETFAPVAKFTSIRALLALSAARGYHVHQADIDKAYLHGKLDKPLYMRVPEGIALPGQVLQLHRSLYGLRQAGRIWNDEIASTLLGLGYIATESDHCVYVKTVGDVHHYIALYVDDLLMIGPSLPEIERTLQGLERCYGVKRLGEAEYVLGIQIRRSSDGSITLSQEQYLKDILARFGMSNAHPVATPMISDLHLEIETNPTPFADRTRYLQAVGSLMYASTGTRPDLAYAVGYLARFSRSPSEAAWGAIKHVFRYLAGTLSHGLCYSHGDSAPVIGYSDCNWGACVLSSKSTMGYAFLYAGGAISWSSRLQSRVADSTCDAEYLALSHAGKEAVFLRQLFGELGLPSSAPTLVLGDNQGANALTRNPVFHARTRHIRLREHFVRDMVALGDVAVQYINTADMTADIFTKALARDLFARHRGRLGICSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NAD2</accession>
    <name>A0A2X0NAD2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C032g11106 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C032g11106</name>
        <name evidence="2" type="ORF">BQ5605_C032G11106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000067">
        <property type="protein sequence ID" value="SGZ05056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0NAD2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912">
        <property type="entry name" value="IP13529P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912:SF34">
        <property type="entry name" value="NOTOCHORD-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1253"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ05056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1300" mass="143067" checksum="76D5077D50B29C0D" modified="2018-09-12" version="1">MSPRTKASEDVLDREFDLCSAPQRSCMGYVCLYCGGERMPRSRAVRHATTKRHLRAVLKANPTFGSRSDRWPLSRSPPLPRDDDEMDWADIEEPTFGTAMVSQPVSVSGPSSPGHDTQHTPRHNDFDLEFGGSPSPLGDVPMHDNDAEVAPQPVHNGADSDDQQVEAEGSAVQASVPTDRLPACDREGVRNYSAVPAPSHPWYPFPSEKVRQIAMVPTLYAQQELDNVLDLATALGLRNLPAASTVEKFLHNLQNEVPLYTPTRHTKEKGRVLHVLSPQNYVAAHFASPAVAPLMHYYPDLKPSNVNSAYHTRRWLSDLPARFSAPMARVDKVDYFVDEIVVIKGVPDMHWFVARFASLRDEIVAFVCLATVSAPSSIEVKLPAFGRPAKDWPTLCASSWCVVPVERFERPVLEHRAPDVCDPATNEIQRSLPLRSVDRALANGELLLVTPLRLFLDDMAATESSRWNPMYTASVQNLALPASVIKRRFMLHHTGVTGTDMGALDLAEFVLTAISDTLGDRPMQCYSVAAGEEVLVRTPLLCSIHDSPMAAECAAQARGWYPCLHCPWGEGGGGGGGGALKTRLTVDQMMTFFECPGLLDAETIRDQALEQLETYANELVMVNFSEQQTSTGTHDVWTKRCLAELAVIFQKEMTHETIGDKGANAEVLAFRAINTSGKDRVRMENRARGSEAVRKAKAEMLERGDYVGPFFDVPCEFSLGPLWAISARVVTRRVVLFTVFDPHKHMPPDILHVFFLGIVKYAGKATLDVDELKKGRRGHLSLRAIMSSMSPVGLPGGIATDHLIDYQGSLVGYDFVTLAQVMPLVAQLRFDLELMPLALNECWGAIGKLGHHLHTANVADLDTYATECEHLVNNLLQASMRRNLSHVLNKSKYHALANLVHAIRMFGPPRLFDASLAESANKVIRQHSMRTNHFDVSQDIARKLGDTERVGFITRGGTWKKDGNRVSMGPAARRLLEDKPAMREWLLLESDAPRQDPSAVRYKFAAGSPFLSDATQLAKTVCFSLPGRGSPDIPRDARWRKAKLAILPNGDPVHPQDWCLFRSDGHNPVLVGQVIELLARESATGRRQGLVGFRLGRIGEELASTGFRTLSRGLDRIVVSIEVSMCRGISNVVALAVVQHNCTHSGCWTNTVDPLPVRTTHKDTDEFLLSTITHRSFDELAAFRPPIKQQVPTEVFVRALLASPTAQALLAAAESADENGEEDRGKVKGKGKSLSTTWLTLPVHQEPTPLATVDEQEECAKGSEEGADTGSDMSDVCDFTGAAALIENDFENQLSTNGQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NBG3</accession>
    <name>A0A2X0NBG3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C047g12326 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C047g12326</name>
        <name evidence="2" type="ORF">BQ5605_C047G12326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000113">
        <property type="protein sequence ID" value="SGZ31175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NBG3"/>
    <dbReference type="STRING" id="796604.A0A2X0NBG3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038910">
        <property type="entry name" value="Hua1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28031">
        <property type="entry name" value="PROLINE-RICH PROTEIN HUA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28031:SF1">
        <property type="entry name" value="PROLINE-RICH PROTEIN HUA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ31175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="237" mass="25768" checksum="F776E6A86045468A" modified="2018-09-12" version="1">MPGPLNPPPQQNYEPTTVPTAGQPLLRNNHILVYPIGKESCPKCHNTGYKPFVGTGGDDPNHPCRKVSKLFKQEFGNKVVVDVVLILDPFPCSQCWEKFGRPFTGAIRIAATATPTPPNYQRPLRLSYRPPTGVQFAGGVYPGAVYRQAQRPGMMQQQGMGMGMGNTYGQPNAAFNAPSRIHVTHQPPIGGGAVVLRPGDPRLGGVRCYRCGGDGTTWGIFFLEETCDLCRGVGRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NPM9</accession>
    <name>A0A2X0NPM9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C012g06826 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C012g06826</name>
        <name evidence="2" type="ORF">BQ5605_C012G06826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NPM9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY16275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="243" mass="27154" checksum="1BC4FE6DD589A468" modified="2018-09-12" version="1">MTLEIQIFLLCFFAGMLFSLAVAILVGRLYHAPSSMTSQTRLNRRLLQVWAPATVSCSAGTYIILIWRKSSPLLHPDLGKAVSNSTGNLVLVLAVLVISSACVSAVVLPILSFFGHLFNTSLSWAHVANDWANYMVESLDLESAPIFRPTWEIWTFATNVLAFFLGPWYKGPRGERSRLLGTRCEGVLEGGSVWTSTKQLNQDVVDFTYTLKDLPSMKFTCWLVCCITALVYSVLYRNMRVNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NSV6</accession>
    <name>A0A2X0NSV6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C010g05905 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C010g05905</name>
        <name evidence="1" type="ORF">BQ5605_C010G05905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NSV6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY13595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="64" mass="7311" checksum="DCB75AE53A67EB5C" modified="2018-09-12" version="1">MRWRCTGADKACNRPDLIARVFEAKSGNKRHAGCFGNECKMNGFCFFATVRLSCYFLNFILPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NTM6</accession>
    <name>A0A2X0NTM6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C011g06649</name>
        <name evidence="4" type="ORF">BQ5605_C011G06649</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NTM6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="3">
        <location>
            <begin position="172"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="738"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY12899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1020" mass="114878" checksum="3C59F79DEF2B19FD" modified="2018-09-12" version="1">MLRLHNSRVKPFLTAQEFMNSEASHMYQLRLLAPRNRDPRTYNLPTQEEVAVILPGDNTEYRSSRRQIVVWLCHPPNNDSSRIQLIHDGHPALMALTYPLLLPYGKDWYHDRIPLSQNAIAAEAARRVQDENGVLQRTTDNTNANPQTGTAGSKHVTQSQFNTYYFHIRPHNISYPTLLLGGRLFQKFVADAWAMTEQERLYWMRANQKKLRAEEYSSLQASLAEGLDPAQIGKRVILPSSHTGSPHQMIQLYQDAMAIIRVFGALDIFITMTCNPAWSEIVNALLPGQTASHRPDIVTRVFHGKLKALLADVLGVGRALGVFGKVIAYVYVVKFQKRGLPHAHILLIMDPEDKPKTNDDYNKIVTAEIPDRDKFPALFETITNSMLHRQCNRPGNHTCHDKHGKCTKRFPKRLQPRTTSEDGAQEEIYTDANVVPTNPFLASKYNCHVNVEIASGVAAIKYLYKYVYKGHDRTSFTIDEPGAQDEINNFLDAQYQQVRFDPDHGAPDLSAPPETTLTAFIKLCAKTPPNHNAQDLLYVEVPTRFTWNNKDCAWVHDKLTTGQSEESTFVPSPTLFADLKTFNGVEFRTFWEACVKRGLLRNDAEAYRCLTEAAVFRTGHKLRHLFAMLLTADDGGTNAAQLWAKHYDNLTQDVEYQLRNQRRQPIITPEHVASWGLLQLSNILQRLDSSLSDHGLPLPTIQFDDEASTNRLIMEKSATAAELDELEGLWRNNFESCNTEQRVVVETVLDLILNSRGKVFFIDAPGGTGKTFLEKTIRARIRSEGKYALAIASSGIAALLLPKGRTAHSRFKIPTDIFDDSTCNVPKQGQLAELFRMCDLIVWDEAPVFPAGGQDVARCAIVNSSVWWTDRCVGRLDPKQCLPIIPKSLPPQIVDACIMNADFWGEVEVLHLSVSSSPSLTFRPYTNRGTVQAQTNMRLLAAADRMTETEREKAHDFANWLLGVGDGSANKTEDSIALPRELLLPATTRNRSGLIRHVYPVPAFELNDMSIGAKIEYFQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NWI2</accession>
    <name>A0A2X0NWI2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C015g07955 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C015g07955</name>
        <name evidence="1" type="ORF">BQ5605_C015G07955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY18024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NWI2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY18024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="452" mass="50717" checksum="A17D67014C64D6C0" modified="2018-09-12" version="1">MSNRPPPEVLLQIVSFSVAPASYHAWTSRSGALRSYCTVSAQWRDVAQALLIQAPVIKTEAVAQRFLARLGAVSIIPSSSLLSNIDHRVGELDLDRDDDDDAIPNQVIELRLGDNEIFTSWTNGFSNIVSRCKGIKRLFVLNADQVILAELGNHSSQSFRPNLHYFYGCNLQFAPPAYYSIPLPPASPSLAPPTPLQIPTLVLPFRFMSLSHSGLPLLISPNSLPHLTHLSLYDVYRSYGLDDAIDPDINNYALLLRTLGPQLKAAKLDLVLYPSFDFDTWLPTLASESRSLTSNTPQDDRYRAGGRLQLFQVSSYEPPSLFLLLQACQSLEVIIADVFPLDRDTRTHLLGPTPHSFVGHANLRRIRFRRGPILVDDSREVENYSVDHRRFQQGSAQEETKLIQNVWGEGVKVAYDVDQSKEGRQRWGLEDEEARFGLTFEAYCLEEGVRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NXA1</accession>
    <name>A0A2X0NXA1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C015g07806 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C015g07806</name>
        <name evidence="1" type="ORF">BQ5605_C015G07806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NXA1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY17523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="168" mass="19035" checksum="6E000490AC1D9214" modified="2018-09-12" version="1">MCICTVCPCRLRQRQRPASAFALAALEWFAAEAPRLHAVTGVHTFASLYINEITCALVFMSVDQGFAPVWTGTNEGLEGLRLLARSLTCPGIDSPVGPCTFLASLQLFNVVQRHANETRMNDMRMRAPICTRMQARQRLYSRVRCQRRRLDLRSAQEWGWGYKSPKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NXF9</accession>
    <name>A0A2X0NXF9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C015g07876 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C015g07876</name>
        <name evidence="7" type="ORF">BQ5605_C015G07876</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NXF9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY17746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="435" mass="46847" checksum="B589705005E2C93B" modified="2018-09-12" version="1">MCLGQGQSAGANRPNMTRQKETPIFEIRSSEAGLRCTVPGWARRGEQWYTIPLPSSPRAKKQKICLIARARTSSFGWLNADLGREGHRAPRQTKIENPDPASSDAVVASLPTFLGVPLGLISLITLTCQNSALTIVLHYGSISFTIAFYNNLRLSPSSRAASAYAPISSQEETFLEESESKESSERRDAPDQPRHELWMISRIIYSVRQTALDVFSSDCWRLLIPACLYVDTHCGNLKILTTALFSVILLRKRLSARKWLALSLLATGVGVVQLQTSAAKEVASGAVGDAHLKHLDGLVAVGAACMTSGLAGVYFELVLKGSQVDLSVQLSSGASPTLPPGNESRPLFAYFGLDNIMKGFATSLPIILSFIAGMILFDFHVTPAFLVGTCLVVGATYLYNQPESQPRAGDSSAAAAFPLALISARSHGPQKPIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P0T0</accession>
    <name>A0A2X0P0T0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C088g13031 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C088g13031</name>
        <name evidence="3" type="ORF">BQ5605_C088G13031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000031">
        <property type="protein sequence ID" value="SGY27984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="902"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1466"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY27984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1722" mass="189835" checksum="FF9693417871C547" modified="2018-09-12" version="1">MFARPEGAELDPEVEKLFSKCVKLNPIVTKATKRFPIARHMYELVFESDQACLEAAAAGPFPYHGKEMVRFTLPSSSSAIPASVLRKSLDAALTSSFGHAGCTQGYTLMQLQRGLAVDPNGDPMAMTEDGFHCAYLRLHADLFQGSTETQKAALNAALPQEIEILGAKYGLRHEFETHYCAVCDRAGHQWGACRKPVSTPATAAPVPGDSTSTTGFRVAGKNGKHGGPAALNSRASGTNMIQLGPRANPAGSATGNKDDANDGDGDDDDDDGESVASTEPEGGDTGKETLTRATTGPTKETQTTTAAPVSTPTSPSPSTSAPASPLSGGTSESSATSTTSIASTSPRRLRSSSAPGNRRVTRAGSAMIHGASGGDDSGGNSSGGYRSESLTVLTFNVRSIKNAVNQVKIIRYLKTLRPAPAAILLQEHHLSYNALREGFESAWPGACIRFAPHVLTLIPDGSPLAGRLLSSTPVVFAEAPQFDGRILRSVFRLEELDIEIINMYAPVKGEERRDFYGLLHFTAPGPKTLRILAGDLNDCPDVSVDRVAITDRAWTPVSHWQTLLSKIAFNPLDTIRQLHPITPAFTRPHYLGRGTNEKSARGRGSIIFLPVVATFALPTSNAADAEPPPALPTTSEFISRLNPTVFNDQDFVDSIPGVVDEVYRRLEGTAPLGDVYDAALRAVAAAGHARYRSTRADMRRLRAENQSVMEALEARGEHMNEAERDAYALAKSQLDQLAVKEAQWLRIRAHVPSVDSREGQSASIRTRLNRRSRQTSIVSLEDVDGTETVDMQEALGIASRHAQSLFTPDPARGDPTNARRSLLDPIRAAKCYDDDRSDPTFGRRLPRQARVALDEPFTLLEVEAALKKTDSGRSPGPSGIPYELFKALPTYFAPKLLDLFNSIWEGGKMTASLAEGLVRLLPKNKPGANLKSLGAYRPITLRETTYKVLSKVLVARLNGVLGELLPPAQHGFMPSRRSADAGSHLTLLLEKLRSLGTDVFPEGALLSLDQQSAYDRVDHAWIFDVFEAFGFGERFISLLRALYDPETLGVRYLINGFPTELVRLLCGLGQGDPLSCPVWNITFQPFLDALVRRGIALDLQKVWPGGRSPAALSKLETLSQTWYEATNGKTNTDKTLVLPLGPNWLRDETAQALPTVQEGESFKWCGYAFFRHGDSKLFWTHVLDRIKAKARAARDRTLSPSGRVFYANAHITSTVLHVLSFDIPPQWFIQAAETALTDFVWGGPRRNTVAREFVFQAREDGGLGLISIGDIVHSVALRFWDAVAGSDEAIWAPLARESWRSLVAATRDFSPWGFFSSTARVEKLVTLPTIKSELLTLPELLSLPPRLPSLYAEGAKHAYDDADAVAKFAQIADLYWRDEGKGWALVGHRRGFWQHSKEPALRHEHVWARVGQKLKAKALLPKTAVRPARIPLKEDPHPRCFNFFGLTRPFTIRKLRRLVNTVRFPGKDGQDRALPGGQPQEPRVKRFPEGTSQSGRQRFWSWLHDRFASAAEQDTHWRLMYDVTPTRKKQHVQGHASSPSCLFCGNDAAVIETVSHYFFGARTRQLLGRGASHSVRQARHRGYRRRSVDVHPEQLTMGLPLLRGRGRTTSKWMWVRLACAIGFQRLHLLRWHVHQRFEKDRVVAPPSIPSALRAFNRDYLSRAGFVPGARDWEWQSLFLDVGSASRKARSFYWIVFCRLPTAQQPALETQPRRDIRRCRGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P0X8</accession>
    <name>A0A2X0P0X8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C001g00861 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C001g00861</name>
        <name evidence="6" type="ORF">BQ5605_C001G00861</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY50174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P0X8"/>
    <dbReference type="STRING" id="796604.A0A2X0P0X8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF165">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="4">
        <location>
            <begin position="32"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="3">
        <location>
            <begin position="302"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="5">
        <location>
            <begin position="690"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY50174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="902" mass="99652" checksum="4A3D67AF4EBD6099" modified="2018-09-12" version="1">MPRIVIPTGFKETTSPGRVAPTCTLRNAQGHTFSVHVVSSEITRVVHALPSQYRQKTNGGTEFETNVSPAEVKIKSKPDSSIVTISTPVTRIEVDYAQCPRLRFFRSSSVHIEGAADAQATCFHADSHTRAYSFDAQSGAVLHLTERENYLPVSEHEDGISRDVNSPLRNEFIYGLGESRGFEKTGRKYTFEGRDALAYTPQNGMSNSGDPLYKTHPFYCVYNKRSQTWHGVFYNSLVDSSIDMGAEGDILFGCFRTYKANSGLLDYYVISPRDGSLPSLISLYASLVSPSHSTPYPISASPVLPPLSQFGYLASSLSLAADPKAQEAVIGFVKKSRGEGFPIDGLYLSSGWCQEEGTDLRHYFAWNKSRYPNPAEFGRTVEQDLQVQVIVNVKPWLLETHPGIHSAAKVGAFVRAPKDALGDPSRASEEGDKRDLVWSSGFGAHALGRYLDYSSKSGSKWWTDSVQQQLLSNNLTGIWIDNNEMAGMVDDDATFKGELGLWNTTTAQGKIGDNVQRRMGWGRGETTVGSVGKAVQTMGMARATYEALLSARPNDRPVIVSRSGLPGIQAYAHASWSGDNATTWATLAHGVALTLSLGLSFGPGLYGHDIGGFAGAHHPSAELLIRWCQNAGAYHSRFTVHSWKETSTTMWMYKGLEPGVTEILRDVLAWRYRLTPTMYSLYVTHYHRRGWPVVKPLLWYHSCDPLTLFESQAYLFGSHVLVASVVEFGARAKRVYLPSSTVGEERQVEWCELDTGVWHTGGQVIVMDAPLSRTPTLVRAGGILVVGPTCKNNLFESFGSRHVLIFPSSAQSGCSGRFTLVEDDGVSNEHTLNGVYTEIDVWYRVKNFEEVEVGFEVSRNEYVTKWKNLTWELPKGDRRKIVGAEGLKGLYDPQGILSVEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P0Z4</accession>
    <name>A0A2X0P0Z4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01009 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01009</name>
        <name evidence="2" type="ORF">BQ5605_C002G01009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY29071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P0Z4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY29071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="403" mass="45472" checksum="5C76ADB77EF7D05E" modified="2018-09-12" version="1">MPTTNSARTYFPKTPHQHVRAAPGPGKRSDLPPTPLSNCGHLQRPRPRSSTDLHAPMSNGSLNTGSISRQKSRVPIEWIDLCSSESDIVDQCAPLHHARTVTDRPSRKENDRRAQSKSAEEVTSEEEVVTHEIHPIEHEDQHFDEVVDDDELISSCSRQLAEMDDSSDSDSYEDVTSKSFPSAGEMEDIQVPSTQVITRPHIQEEGTKKEKLIRVAVMFLLGKSKKSMQRRTGLSISRLTRLLQIPLADSIARGRRRRIFEAAQDVFDQEWDQRYNNSRCSHLTAEDSSASHPSAPSSPEIRPGKPSSSRSIFTSHPGQQSKAAASRLVAYRYSDLQLVTYYSTWLMGFSKVEASRRSGVKAQSAAAFFWDERLSQWNRERRRRIVAIAEKEAAKAQRKGRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P2B0</accession>
    <name>A0A2X0P2B0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C002g01649 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C002g01649</name>
        <name evidence="8" type="ORF">BQ5605_C002G01649</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF11 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY34541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P2B0"/>
    <dbReference type="STRING" id="796604.A0A2X0P2B0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08048">
        <property type="entry name" value="HFD_TAF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045127">
        <property type="entry name" value="TAF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006809">
        <property type="entry name" value="TAFII28_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04719">
        <property type="entry name" value="TAFII28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII28-like protein" evidence="7">
        <location>
            <begin position="142"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY34541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="244" mass="26852" checksum="C7B4E24C8805EB75" modified="2018-09-12" version="1">MPPMKRTFSQTMPPTERSGSAPSQIKAKVKKSKKARPPAASPGPASMGTPLASSPPYSGMMDSPRPRGRSRSRSRSASVAPGFGASKGKGKDRDAAQDEHAADPVEDAEDEDNEDEEELLFSDDEFGVNQKESAKQKQYLRVLLEHFDATQMDRYEAYRRSGLNKAVIRRLVNSVLQQSVSAPILTVVRGFAKVFVGEVVEKARSVANHDGPLTPDDLREGYRLYQAEHERVIAAPGKKKLFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P3F3</accession>
    <name>A0A2X0P3F3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g02140 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C003g02140</name>
        <name evidence="1" type="ORF">BQ5605_C003G02140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P3F3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY39093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="69" mass="7558" checksum="1DE33246ED8DF1D9" modified="2018-09-12" version="1">MTVYPREYTALSAAQAGSLGVTLLYSCRAPTLCICTPGSTQPLQGPWPMDRYPCSLDYINYHVNGVGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P4Z3</accession>
    <name>A0A2X0P4Z3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BQ5605_C004g03011 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C004g03011</name>
        <name evidence="12" type="ORF">BQ5605_C004G03011</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosyl-DNA phosphodiesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY69412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P4Z3"/>
    <dbReference type="STRING" id="796604.A0A2X0P4Z3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017005">
        <property type="term" value="F:3'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09123">
        <property type="entry name" value="PLDc_Tdp1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010347">
        <property type="entry name" value="Tdp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415:SF0">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06087">
        <property type="entry name" value="Tyr-DNA_phospho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="70"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="541"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="543"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY69412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="647" mass="71987" checksum="D9F3D6AA8728CB7A" modified="2018-09-12" version="1">MAQKRPIEQITIDDSDDEGVNNQQVLSAVNVARGSDDVELQDELEETEQQQLAQAIALSLLDTTVVNPHTAAPASASQKPPLTDRQLDEKARLERQREWEKKHNASNGRIRAAGPSPIAAPAPPAPKRSRPNVVTFSDLPRNNVPNIPSNATASTSRTFIPPVETTRKQSNRFWEGAIRRVHNVLAQPDTFGESFTFAQLVAADQKLEMAIVGSYCLELEWVCSHFKADTPVMLFRARHSDDHPARYQKVDDLIKPQTFLILPEERSLPGPWKGTMHTKLLMFYYKSFCRIVIPTANCVEHDWSIIDNAFYVHDFPVLQDTPNTSRSPEHNPTHTPFSRGLLEVMLSMLARVKQHLLSDSAPDSGNWCSAGLGLTKKFTTPYRHFDFSSSAEVRLIATTQGVWKGFDKMEQGGGGLCALAKAVQEITSPSPGSRWMIEYQGSSMSKCSDNWLAQFYGAAAGIRPRAWFRPNIKRPAALPANTADLPLKIVYPTMDEIRNSHLGEPGGGTIFCRCDMWQSASRGFASLFHRGQSKRDRVAAHTKTMVALRKPPRGASAAPCPPSYKHEGYIYVGSHNFGPSAWGQLEHSSDTKEPQLKCNNYELGVLVPIRGDSDAELEAKASEIATYRRPLIPYGPRDEPWMQVPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P7P3</accession>
    <name>A0A2X0P7P3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">BQ5605_C006g03812 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">BQ5605_C006g03812</name>
        <name evidence="17" type="ORF">BQ5605_C006G03812</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY53875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P7P3"/>
    <dbReference type="STRING" id="796604.A0A2X0P7P3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="16">
        <location>
            <begin position="123"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="359"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="SGY53875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="380" mass="42934" checksum="4EF26D89E087B272" modified="2018-09-12" version="1">MRRKLRNRKRGPRWDRPRCRLVLLKGDWIDNQVYGIQQNQLSILDATPIRRRLSPVAAAAIPLLTLHQRFGHLSLPNLQRAISSGQLQGQTWTYSAAECNTFACNTCKTAKATRTPFQTLTSRASQPLKLVHSDVLTLPEPTSDGERYVVTFIDDYSRKMWVKALKNKSQVFETLKSWHTMIERSTGLPLRTLQTDNGAERLNHTIVEGTIALLQQSGLPMKLWQEALLYVVDTKNLSPHSALDHKIPDAHKRSKLEPKAKPFIFVGFNNKSKAWTLYDPTMTLFFLSRDIQFDEQVFPARDAPIGPPQPCMPPTTGEWTFVNAAHALRAPPRLSTPPVVHQNRFAVLETEDSDDATIDMSNNSFDTPSDMGTSVVARAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-10-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P823</accession>
    <name>A0A2X0P823_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C008g05234 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C008g05234</name>
        <name evidence="2" type="ORF">BQ5605_C008G05234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P823"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024675">
        <property type="entry name" value="eIF3g_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12353">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Eukaryotic translation initiation factor 3 subunit G N-terminal" evidence="1">
        <location>
            <begin position="49"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY79839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="183" mass="19630" checksum="5B721DDDF75A0DD8" modified="2018-09-12" version="1">MVLAWYFYKEYYTQALRQDLDKLPDPIEALQTLQTQAESTPAHKPVAMVASLTATDRSSSTPSAPCRHCGGPHWNRKCPVKDKKSKASSAPSASLAAAPDISTLVDGPVRGYLTAAMSTLAKPSLILDSGATHHIVNDRACFTNFRKCKPAPLEGITGEAVNSIEGVGSAVVRSLPSARLYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P9W0</accession>
    <name>A0A2X0P9W0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C007g04612</name>
        <name evidence="8" type="ORF">BQ5605_C007G04612</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY61851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P9W0"/>
    <dbReference type="STRING" id="796604.A0A2X0P9W0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF27">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN CTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016066209" description="Copper transport protein" evidence="7">
        <location>
            <begin position="34"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY61851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="270" mass="29319" checksum="76D168309A6F3B15" modified="2018-09-12" version="1">MFPARTHPTAPSTSTIALSRLVLAAIGPTLALAHGSDMQMDMNMSNSSTATMGTSFSTTNFSLLNSIGSSQLWFDGWIPTSSASTARACIGLALLAILSRFLAAVRTSCEANWTQSILRQRMAQHQPLVDATLLNTVPTMPSGRSDRGAASDPSDKAQASNRSELGDLLHKFHSSPAPFTPSIDLPRTVIFTVSYRDYALYVTSPRTGIEFLVFRTTQLQAFIGYLLMLAIMTYSAWFFISILSGLALGELLFGRFINRHGHSSDLGLHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P9Z5</accession>
    <name>A0A2X0P9Z5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Inositol-3-phosphate synthase</fullName>
            <ecNumber evidence="7">5.5.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Myo-inositol 1-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">BQ5605_C007g04763</name>
        <name evidence="20" type="ORF">BQ5605_C007G04763</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10716"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="5.5.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the myo-inositol 1-phosphate synthase family.</text>
    </comment>
    <dbReference type="EC" id="5.5.1.4" evidence="7"/>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY62987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P9Z5"/>
    <dbReference type="STRING" id="796604.A0A2X0P9Z5"/>
    <dbReference type="UniPathway" id="UPA00823">
        <property type="reaction ID" value="UER00787"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004512">
        <property type="term" value="F:inositol-3-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000334">
        <property type="entry name" value="Inositol-3-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000069">
        <property type="entry name" value="Inositol-3-phosphate synthase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000055">
        <property type="entry name" value="Putative myo-inositol-1-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002587">
        <property type="entry name" value="Myo-inos-1-P_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013021">
        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11510">
        <property type="entry name" value="MYO-INOSITOL-1 PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01658">
        <property type="entry name" value="Inos-1-P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07994">
        <property type="entry name" value="NAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015578">
        <property type="entry name" value="Myoinos-ppht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0398">Inositol biosynthesis</keyword>
    <keyword evidence="14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myo-inositol-1-phosphate synthase GAPDH-like" evidence="19">
        <location>
            <begin position="349"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00070063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="SGY62987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="570" mass="62714" checksum="E911BC8AF39143D1" modified="2018-09-12" version="1">MAPIALDPPAPASTQPASRYNASASHGNSAAIPIVDPTAARRPVEGVQVESENLTYTDEALIAKYSFHSSVVKKVGERYQVKPVVKELELKTLRKVPKTGLMLVGWGGNNGTTLSATLLANKNNISWNTRDGTQSPNYLGSLVRASTVRLGEDENGRDVFVPFSDVLPMVHPNDLVVTGWDISAMPLDRAMRRAKVMDYDLQRQLAPMMAELKPMPSIYYPTFINANQEERADNVLPGNNKAEHLAKIRSDIRNFKANNNLDTVIVLWTANTERYSELIPGINDTKENLLKAVDASHPEVSPSTIFAMASILEGCPYINGAPQNTFVPGCIELAEHHNTLIGGDDFKSGQTKVKSVLAEFLVNAGIKPLSIASYNHLGNNDGRNLSAPEQFRSKEISKSSVVDDMVEANHLLYKPLLEDPKGEKEVAKGDKVRKTEHPDHCIVIKYLPAVGDDKRALDEYNSEIMMGGRNTLNIFNECQDSLLATPLIIDLALLAELLTRVTYRQAGQGEFESMYQVASLLSFMLKAPLVKPGKQVINSFSRQRNALEAFLRACLSLQPTSDLINFTNMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PFM9</accession>
    <name>A0A2X0PFM9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C024g09926 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C024g09926</name>
        <name evidence="6" type="ORF">BQ5605_C024G09926</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ26491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PFM9"/>
    <dbReference type="STRING" id="796604.A0A2X0PFM9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="5">
        <location>
            <begin position="43"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGZ26491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="108" mass="12295" checksum="DEDDC5907BA91B38" modified="2018-09-12" version="1">MKTIAAKYPRTSGKFAKQAVSSIKRPYRFKPGTVALPQDLHSHGHALRFQESALQALQEAAEQYLIDLFSDCNICAIHAKRVTIQPKDMLLARRLRGDNLRQYENVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PGZ3</accession>
    <name>A0A2X0PGZ3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C055g12646 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C055g12646</name>
        <name evidence="2" type="ORF">BQ5605_C055G12646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000092">
        <property type="protein sequence ID" value="SGZ29206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PGZ3"/>
    <dbReference type="STRING" id="796604.A0A2X0PGZ3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="1">
        <location>
            <begin position="100"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ29206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="305" mass="34928" checksum="494555BD3247935B" modified="2018-09-12" version="1">MHAASRIDTEGLSLSAGIYRDNFRTLPTFFGDDESFDDIEPRALEVVFYRQCYQPLNTATTTKELAQAVLGVVKGEHEDQLGGLAFALPSRHARSYDNAGHRNLYKLGYIHRDILYGNVVIDRDSFGILIDYHLAVPHDQPYTELHHRMRFGTWPYLACSILTQPEQPLGVVHERWHDIESLFYVVMESSFHEPYQGDEEVLMMTPRGETIWRRWKSPDADLVYALKLTLCMDMIYKSSLDGCAYRFPSIQLILSILRRNCGLDSRFLGLEVAEEEAQLGELWGPSKAMSHESIISDIEQLLPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PHZ2</accession>
    <name>A0A2X0PHZ2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C031g10961 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C031g10961</name>
        <name evidence="1" type="ORF">BQ5605_C031G10961</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000068">
        <property type="protein sequence ID" value="SGZ06688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PHZ2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ06688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="44" mass="5129" checksum="C047DF06EF276CB7" modified="2018-09-12" version="1">MVFESEEDLQNDLLYYEILVQIVAGIIRDRFAAVQWSEQGLDPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PJ83</accession>
    <name>A0A2X0PJ83_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C029g10669 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C029g10669</name>
        <name evidence="2" type="ORF">BQ5605_C029G10669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ15411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PJ83"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ15411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="137" mass="15545" checksum="3571175AD62C6991" modified="2018-09-12" version="1">MVTLHLKGVHSAENETPSCTSTLNVTIHIMLGLPRVRGGSRDSRTYIVVRVVLAIAFNRLYLAYLARWHQHKDQIPLPTPYFLTREVRSHLKFRLRRLPDGELLDQMMVVGAHMIGITLLVVSGVWGLHGSSGYDFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PJS0</accession>
    <name>A0A2X0PJS0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C028g10547 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C028g10547</name>
        <name evidence="2" type="ORF">BQ5605_C028G10547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000080">
        <property type="protein sequence ID" value="SGZ13088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PJS0"/>
    <dbReference type="STRING" id="796604.A0A2X0PJS0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="382"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ13088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="528" mass="56085" checksum="5DD18ECD65541897" modified="2018-09-12" version="1">MATVTGSRVASRSQAPSPASPSSAASASIKSYYRAATSAFLIRDYGHTSQSLHSAQQVLFVSASVSSAPPPSDWVHTLAESNTIPPKVEWARKLTIFEITFLATCRSHPLSTPATSSSALHPTHQYYIDLPVDALIPTLWSRLILQDPTGSSSTNIHASPLASCVHPSLVVALALAALKLDQPRQARAALEAYLGSISEELESLIEGAARSVDWAIEFQLDETMSMSIHGHHNTTHAPNNLSSSGILHPHMDPTRALLASWLKVVDLLSLHVLPRLGQWEAAGDSIRLQSVENAGWIGDVRLDAALHRLAALQREEIEQSASRGQRIRAQKEAVATAAAASALAMEQQQAAQRRARANDKGNARAVTNEGMAKPPPHAQRQSSSDLSSKGSPGSSSKSSHNGHGRHSAGSRSSAAPDSHASETGFAAMRSSLTSYLSQAVPSTSTTTSSALSSNRSLSTALFESLKGHDPVRLLSTVCVAFAFITWVRRTTARRRADGKGGLGVVEGLWTVVGKLGEVVKMGTKVTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PLT7</accession>
    <name>A0A2X0PLT7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C023g09738 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C023g09738</name>
        <name evidence="6" type="ORF">BQ5605_C023G09738</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ24665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PLT7"/>
    <dbReference type="STRING" id="796604.A0A2X0PLT7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050295">
        <property type="term" value="F:steryl-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904462">
        <property type="term" value="P:ergosteryl 3-beta-D-glucoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041036">
        <property type="entry name" value="GH5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052066">
        <property type="entry name" value="Glycosphingolipid_Hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308:SF6">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18564">
        <property type="entry name" value="Glyco_hydro_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5 C-terminal" evidence="5">
        <location>
            <begin position="732"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="668"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="681"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGZ24665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="978" mass="109446" checksum="3FAA4215BF740DA1" modified="2018-09-12" version="1">MAPVSSTSPVTGSVVPPFYIHSSSRHFRTVDGRTILLRGINLAASAKTPVGQPGAQLDGFWEHAKDGEMSFVGRVLDLHNGVADRHLERLRSWGFNCLRYIVNWESIEHKGPGQYDQEYIDYTIALLRKCKQCGFLVYMDPHQDVWSRFSGGSGAPYWTLIACGLNPENFTVTNAAAIECEWPHPDHPDPTTFPAMIWASNYSRLATQTLFTLWGAGRDYAPKCIINGINIQDFLHEHYFNAIRQLGNAIADAGDLLDECVIGWDSLNEPNGGYLGIDDITQHGKESILKVRTMPTAFEGMRLAMGEAVEVENWRFSSLGPKRDGSVLIDPKGARAWLDSDAENDGSPYGWVRGPDWQLGTCIWGLHGVWDVETREVLQADYFKWYRGPQPAEEARREVFYGSDYWLVHWRQYAPIVREFHPEAIHFIHTPVFQIPPKIEGPEIQNRAAYSTHFYDGLTLVTKHWNWFNADALGILRGKYASVVLGVKVGETAIRKCMREQLAMLRQDTFDALGQYPTMMGEIGVPFNLDKKKAYQDGDYTAQMRALDASLNACDGANALNYTVWTYCPDNSHQWSDRWNGEDLSIWSPDDAERMDDFRGSNVRLDLMGRIPVTRARAASKASSLDLSRNSSSGQLSAMGETIAAHPSDAIGAASLALVVPMHGNGARLTSSSSANSSQREFSKSQDERSPSSTSSASLLPPLASQPACYSFESEKIISLNDGARAIAAFCRPYPILTVGTPTNINFDIRSSKFSFEVELDSDDFTSDQGELATEVFVPLIHYAAYPSRVSQLIKNDDNALAKLTAPTAANYAVYHSKRTPPAPTKDEEASDELDARGAQLASSLTELEDPFKLALKVKISAGRWETEGQRLKWYYPRPTQGKVMLKIEIEREKGAIPKWVNQWERTPKLRRFYDRCVTYPTCLPCTHAGRRINAQHAPTFGRTASAQTFGRVLRSVAWSAICMGLVWTLYRRFIYFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PN28</accession>
    <name>A0A2X0PN28_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C026g10242 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C026g10242</name>
        <name evidence="1" type="ORF">BQ5605_C026G10242</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ27996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PN28"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ27996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="65" mass="7207" checksum="FEED0F208E78821D" modified="2018-09-12" version="1">MRVCVLMHILCTVKRSRIQSKTKTNHCSRSSIFRVSTSPGWRCSTLDAGLDDGLSPSSGPQRTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PQ72</accession>
    <name>A0A2X0PQ72_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C040g11872 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C040g11872</name>
        <name evidence="7" type="ORF">BQ5605_C040G11872</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000118">
        <property type="protein sequence ID" value="SGZ32433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PQ72"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF117">
        <property type="entry name" value="SERINE PROTEASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015926461" evidence="6">
        <location>
            <begin position="28"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGZ32433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="570" mass="64967" checksum="C52BFA23A946EF72" modified="2018-09-12" version="1">MWSQQKGHTKHLLSILLCLTFIHGGRAAYKSTDLLCAPRVPVQLYRHLRREEQAQIETAQLYSTAGDHSTLRFSTPVAPEYPAYTFDQRVSHLDDVPAPVEKETFKQRYWFKAEHYKPGGPVFLLDGGETNGEDRFPFLRQGVLEILSKAHNGIGIILEHRYYGESFPVENLTTDSMRFLSTEMSLLDSKYFAQNVKLPGVDHFNNSLAPWIYCGGSYAGAKAAFARKLYPDVFWGAIASSAVTKAIAEFSEYYEPIRKSAPRQCVNLLINHTNLIDQLLDLKNYAVTSSLKSLFGLPNVTMADDFVNTLATPLGSWQGQNWDPAVGSRKFDEFCDALTNEKIEVSSEVRGAHTGLEDGINHFGWSWPNPKAFAELAKYAQYIRTNVASLCPAEMRQDECFGNEGVDLTGLDQSSWRSWTWQYCTEFGYFITSSPDASERLVSRRIDVKYTRAICQKAFPDGKVVRMPNRPNVEKINKWGGYKIRAPRLAFVDGSRDPWLYATPHSPHAKDRKDTLEEPFKMIEGGVHHWDQNGRPRSEPGPIRAIHSQEIEFVAHWLREWEERGRWRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PQH2</accession>
    <name>A0A2X0PQH2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C077g12944 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C077g12944</name>
        <name evidence="3" type="ORF">BQ5605_C077G12944</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000126">
        <property type="protein sequence ID" value="SGZ34526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0PQH2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1264"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="652"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="560"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ34526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2110" mass="235093" checksum="895AF5F422533880" modified="2018-09-12" version="1">MSTGDPGSPPPAPPPPVSATSVQPPRDQIPISSKKTQATGPATAAPNYAAAASQATQSPEQQQQQQQSAKALGSLLQAMGAVPGNRMDRWVQAIYFAELYPVATATSLKFSALNANRSVENIFDCALEVTLSHQSASRASHADKTDLVACVTRLLSPISPICFEPGVPLPDHLAAYRPQILGVQHSSILRNGAAHHRVTVGFVTGEARDAAFTTPPALTWRSAKARFAKSHRFHHNMVELRINVGVQGVPSMDAIIKSFQLLVQDLSGKGHSCQLVQVLRIISVDNASAFAHVAGDYSAFLHFDDDSLFKRPNTTLKEILPSRIGLPTRGIPVTALRHDYEKEAACGRCHFVGHVGTCGLDQESKRKEAHNGNGNGNTNANKNTITNDTNIVEAEAPIPVPVVNRIASQNRFAGLEVEEGQEEAVTGQSGQGPEESGEEDAGDKADDEDSEDSEMESEATAKTEVIKLKSEDESVLEDCGGSDGEVIDEDEVMADGRGETEGKVATEMEEREVATEMEEEEVATEVDDVDEAGGATKAENAEATDLGETNRLDNDDDSDATATAATASRESTPHEPTPPLSPETLAKSLREGEEWDRIRANWVEQARLERDQSIERRLDAETPLVRHNFATWDEDGEIRSINIRGTAAKFKKPVMKRSQTAADLSDPSDEPTDAKRVIIKGKSRVVVKDGTEGRRVTRSMSAAAAMPVGVTKVDRGKAKGVAEEKRWSDHEPEDDRFDLNYPLMIKHTIITWNVRRGMGVPEKRRDIYNYLSLFKASAILIQEHFIRPHLWQLIKDEYEGKLFINQHCLTLIPADSPLIDAELLRTHSALDGRLLVTSFRLRGDIKILEINNVYAPVDPKQRAKFFDKLLFHKTQKSHLRLLGGDLNDCPRPEVDRRNQSRRGHHWPILIGKLDSAYTDCIRYKHPITPSFTRPNPNRKRPNSFSRLDYFLLQRTHQKRLDQASTIYDYPKELSDHRPVLIVLALSDDPDATLPQLSLPTTSNQLHRINTTTFKTVEFQRMMEGWLEGASGEEPVGELEVILKACRDRGGEMARRLHRERTERMEYLVGRVQDLEAIPEWGEAETAEWTRTSEELKRAVEERARLLRIRAHVPEIASEERLSRPVHAKLAARNSDSKITALRLSNGELTHDIDVALDHTQAHFQRLYHIEPRDPDRVDRLRDEFLAPIRAARTCDDPRSDPLFLRRLSESQIDLLQRPITEDEVVAAIGTTHPGRSPGPSGVPYELYQTAPKAWAKVLTKAYNAMIERGSLSPKQGQGLVRLIFKRHKKNADRAELSSYRPITLRECDYKIFTKVYVARLNQILPDLLPPQQHGFVKDRRSADAALHLRLLIEEVGARRTEFPAAALLSLDQSSAYDLVEHDWIFAIFDALGAPATFLRVPRMLYSGDSTSARYIINGFLTAPVRLTCGLGQGDPASSSVWDIVFQPFLDVLHRRNIALNLSIPALHPYPQSRAITSLAFADDVVVAVAGLGSLNLLDDLALDWRHPTNGRLNTDKTVVLPIGRRWDPGQRPLVVKAAGESLEWIGLPFDPSGDTELAYANLIERLEATLEGVQHRWLTHHTRAFYVNRYAIPKILHFLAADIPPPEVVKKLDDMLVDFVRGGKGRTSYGRDIVFTAKLKEGLGVIRMQDVVDAVAARIWDVLLGGSGAIWQGLARAALQRAQSDLDLATDLWPHPSTPIPSDLHPRWRAALGVPKQQDAQVNPRTLTTANLLALPTLLGSLHAPIRGRQTIDAVHIPDYLRLQGYPKVADLYRRELYAGGGFHLWTPPADVLGDNSEYDRRGLPQRLAIAAWYRFTVDRHKNTPLAVAVAAGRLNVPPRIGTSAPLEAILPKPVARFAMEQRLPDPVLPQQASQYKLLNMARPYTIRRIRRVLNAKAFTNTLGLKGPPQPDDLRSFWKAVNSKALTAREREVWFKLILRFTPTRKLQNQQKHDTSPACLVCEAPVDDTDHYFFGCVDSRNVWIAARGVLCDALGCDTIEDAQYTTLQRLFGLPKLKAKLSEQEGAGRTIEMFTGMVLEMISSGRWRMQKHGTRMESVERRRVVLEERMKLRAGGAGAGEGSRGWVRFPPPTTPHTHTPSRFIFQQNTVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LQF9</accession>
    <name>A0A2X0LQF9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C010g06090 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C010g06090</name>
        <name evidence="10" type="ORF">BQ5605_C010G06090</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VPS53 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LQF9"/>
    <dbReference type="STRING" id="796604.A0A2X0LQF9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.110">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 53, C-terminus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039766">
        <property type="entry name" value="Vps53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031745">
        <property type="entry name" value="Vps53_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038260">
        <property type="entry name" value="Vps53_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007234">
        <property type="entry name" value="Vps53_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16854">
        <property type="entry name" value="VPS53_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04100">
        <property type="entry name" value="Vps53_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps53 N-terminal" evidence="8">
        <location>
            <begin position="164"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Vps53 N-terminal" evidence="8">
        <location>
            <begin position="240"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Vps53 C-terminal" evidence="9">
        <location>
            <begin position="722"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="887"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="887"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="917"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="934"/>
            <end position="943"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY14176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="967" mass="104520" checksum="B243C23C3E15FEE2" modified="2018-09-12" version="1">MPPPTLVLPESDAQPPPPQHAGHPTGLLPDLPHELLIALGQAIDRDALDSFVLSSSSSSSSSSRSAASGTATNGGGGPLRVEEVLNELIPDEQAIAQTPLVSLLLRAKIQDLRIEIQGLTLLLEQDQSPHNMTLIQELIGVESAGTWANFFPSPTHSLCRSPPQELLSQVTAIRNAATESEMVVREITRDIQSLDLAKRNLVASITALKRFQMLGPFEQRVHRSTRPWKTDLFRSNSETVSAFDQLNRLAKSRRYRETAQALGAVKQLSSYFKTYGSVDRVAAVSRGVVDVQGVLRTQVMRDFEEAFASEASRVGKNGQLADACLVIDALGEEAKNGLFSWYTVLLLRDYRKVFGSNSEAGQLDNISRRFAWFRRILKTHEDENGTIFPSVWSVGAVLAGGFSEVTRDDLKSVLQKAAPGLQVGLLLEALGQTVEFERELSRKFTLPFDYIASLSAVRSGRSGPTAPISAVFEPYLGIFVDAQDKTLSDMMGAFTSSRVSISPSDNPSAVLPSSTELFYFYREALERCAKLSVKQPLLDLCKVYRKWLKVYAEDVLAGALVKTDRRSVEGRGPSLHELQTACLVLNTAEYCLETATQLEERLIEKIDADLKAQVSLEREKDLFVQTTSASLLAILKELEMSLEGPFNLMLRSPWRDVEYVSNESPYVADLVRCVETVVTVVRDGVEQKKYVRSVCDKIVGLVLAKFTQTIVRCRPIAQIGAEQILLDLQSLKTCLLHLVLPPGDTSAVPMSYSRYVSRSVTKIDTLLKVIMTPEEPAEEFVKNYLVLVPCQSFSDFQKVLDLKGVRRAEQNNLLDIFLARTSTATGLDDTSFLTSLDMDPNATFQSPSGSGVSSPLLGSSNTNSNALGGSMGGGGGFLGLGASTLGGSGGGSGGSREGSRTSTPIGGFGRAGSLSGPSGGGQGQSGPGGGSEGGHGHGGKEALAEFRKFGQRIGMASRLFSGREGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LRK2</accession>
    <name>A0A2X0LRK2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C013g07362 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C013g07362</name>
        <name evidence="5" type="ORF">BQ5605_C013G07362</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LRK2"/>
    <dbReference type="STRING" id="796604.A0A2X0LRK2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03357">
        <property type="entry name" value="LbH_MAT_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051159">
        <property type="entry name" value="Hexapeptide_acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416:SF23">
        <property type="entry name" value="ACETYLTRANSFERASE C18B11.09C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416">
        <property type="entry name" value="SIALIC ACID SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Maltose/galactoside acetyltransferase" evidence="4">
        <location>
            <begin position="37"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY15412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="241" mass="26295" checksum="E396A81760D182C0" modified="2018-09-12" version="1">MLPQTLQPQSQIPAIAAPHAQTDDEDAAAAERALIERRKMLAGEAYDAMQDQGLLEGRLRARHLLHAYNHHPPAAYLKGMGEMDYFGPDSRWSILAELFQIPLEKMKKIAIEPPFYCDYGCNIKFKGEFYSNFGLTVLDCAEVTFGDRVLVAPNAQVYAATHSVDVAERQAGLERAYPVTVGDDCWLGGSAVLIGPCHIGNGCTVAAGAVVRGNFPDNCVIGGTPARILKRLDPPSEQRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LS17</accession>
    <name>A0A2X0LS17_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BQ5605_C012g06815 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C012g06815</name>
        <name evidence="11" type="ORF">BQ5605_C012G06815</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VTI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LS17"/>
    <dbReference type="STRING" id="796604.A0A2X0LS17"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15862">
        <property type="entry name" value="SNARE_Vti1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000002">
        <property type="entry name" value="Vesicle transport through interaction with t-SNAREsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.400">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038407">
        <property type="entry name" value="v-SNARE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007705">
        <property type="entry name" value="Vesicle_trsprt_v-SNARE_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF26">
        <property type="entry name" value="VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05008">
        <property type="entry name" value="V-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vesicle transport v-SNARE N-terminal" evidence="10">
        <location>
            <begin position="5"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="100"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY16236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="226" mass="25357" checksum="3B4A22757B4BFC07" modified="2018-09-12" version="1">MDSSSPIFDEYAQDLSTLLTAIRTQLDGAASQAKGDERRALLRRLDMELDESDEIIGQMEIEVQTQLNPLDKQDLHTKLRRHTTTLAAIRQQIKRLETNTDRDDLLSTSSSPHVTIPISDSEDPLRSASSAQAQRIALMSTTDQLSQGQRRLQESHRVALETEHLGAGILRNLRGQRDVLQHARDGLYETDGSIDRASNTIGKMVRVMHQQKAITYAIISVLVFLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LTZ3</accession>
    <name>A0A2X0LTZ3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C011g06600 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C011g06600</name>
        <name evidence="2" type="ORF">BQ5605_C011G06600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LTZ3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY12784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="296" mass="33109" checksum="43CC4BEB234DDD35" modified="2018-09-12" version="1">MADPTLSSPHHHLFLRRGQRQMAVCAHCKARHWECKGRTGHFSMCCLQGKVQLSPLSGPIPSINSYLKARIAICLIDPAEATDTRLGLDGADSRIQRSTLNKLESMLRTKNHFTDAPTTFLRRARKWRCLSAIPTPTREIVDVKTLFSRCTVIDVPRVGPSTKSLARSIHGFHPNIPLCGSIELGHSSPKDRNKEGEDEEEGDKKNGDGEHKHLWLLLGCSHSVKARAQTDIECLNTYDEGQVKGVKVVSLAFTNPLRSTCTNATSPHGTRRPFPAFVIERYSQAEADRLNYIQWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LVZ4</accession>
    <name>A0A2X0LVZ4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C019g08830 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C019g08830</name>
        <name evidence="2" type="ORF">BQ5605_C019G08830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY22619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LVZ4"/>
    <dbReference type="STRING" id="796604.A0A2X0LVZ4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY22619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="133" mass="15318" checksum="8A9E6D198F67AA36" modified="2018-09-12" version="1">MMMLEQEEERLRNIARRWFSKGGLDHLWECTRQTGEPQVEEWVELRMWCTDDVDVFQRTTAGGLPDHTWPYCINDGMVGESDDITTDHDTLLDISDHSSDDLSHHSDTTDYGAFSDEINENFDEDDGDVFGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZR4</accession>
    <name>A0A2X0LZR4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C016g08283 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C016g08283</name>
        <name evidence="2" type="ORF">BQ5605_C016G08283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY21856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LZR4"/>
    <dbReference type="STRING" id="796604.A0A2X0LZR4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35711:SF1">
        <property type="entry name" value="ECTODERMAL, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35711">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1037"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="405"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="532"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="577"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="675"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="725"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="746"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="781"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="856"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="878"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="919"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="939"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="959"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1053"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1087"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1191"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1213"/>
            <end position="1222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY21856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1222" mass="130544" checksum="5B97A5F712723F92" modified="2018-09-12" version="1">MSSSTTKPKPKSRSSVAGSVSSSVPNAVDPKLMELARQIGIARFNALVQSRAGSTSTSTSTAPPLNPAPVPKPTSGPTPESSRSKADETPAERKPTSKRKSVNSVALAVVETPPSKKGKSTSKHDKHHNDEDENGNDAPTHNDEEERKARKKQRKLDKKEAKRKAALEAEADMEVDELESPVKDRKQKKGKKEQERTDKEAKKRSKKSKKLDKGKGKEIVQDNLNESCSSAANHHPSPPPKPIAEAKSKSKSSSKRPRPSELASEVAVSPVKSPRKKRKLANGSSAAVPSTQANTAVSAPVRPAVNGFPPTSTDSRDLEQLLVQTVNALRASPSYAHESGVFGEGIVRLFQALVAKVASADMRPEAPPTSNHDDDDSTTPEEDEHEYEQHRRLSQTSGRAPLNGTEAPVASTSTSSSTRPALTSTFAARPTAAPTATPTADAPETEAEAAIKARAAKAAKKLLKKERREKKQQKEVAAEAPSSPPEEHEVVPPAPDEEDGPATPLSSPDKSERLNKDRPIRKRLGKLEKGALRSMSQSAGSSRQSSLAPTLTLPPAREELVIKVSDSQAEEAERAAIRAAEATPESSASSPDEDGPLNHSTDPTIRFRGEDDEASENEIDQLASTPVLARPSHPLRQAPRSTISAFSSEDDPEEIELSLRTHTSPRKERPLSLDPEVESGDEFEPRTEDDDVEGKHEEEDGHARENVNDGSEEQHENRGEEDDEPTARPRIEHDGDAAMADAQAQDESHVEKDAVRQASPITNGAVPPSPGQRQPVDPANVPLPPSPSPPPPIRTIGHDDSDASSSSDDDDSDSSSSSSTASNRAYRKPSRPSIGAVATSAFGSAASMRKNRAKRQSSPLKTSSLARTLSSTGPEIDKDAEMEEDIDELLSQPVPKSAVQKLLQDAEEEEQRLEEPRGRSTSVSSSEADTTTAGAVAEPSKEGAVEVQRNGDGEVDAGSTKSLKEVNSSLEATTAEPIEAVNLSDIAAQASSTPGTPLMMDAQASQLFRLDHHEVDSDESQYVPLIKSQPFFLEETQPTQRLPGFVDHEGQESQKSSQTILNGSSQVKKAVDAVTLDVPSHATPNGRLTRAASLRARTVSPGPSATAPSASAPSSKNSVSSRPPSASQPLPTTSFRGHGRASSMRALSQLDEATPRRSMRHAGPLTSQGSTFSAKGAAVPALSWVRKGDDGENESEDDSSEDEDRKANGTSTRPRKSKVLWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZR6</accession>
    <name>A0A2X0LZR6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C016g08284 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C016g08284</name>
        <name evidence="2" type="ORF">BQ5605_C016G08284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY21862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LZR6"/>
    <dbReference type="STRING" id="796604.A0A2X0LZR6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY21862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="142" mass="15030" checksum="CA3E2F81FEDBCB26" modified="2018-09-12" version="1">MAITEHVKIAADDPSLLPSDDDDDDFTLDDDADGAGSSGSDSDSDDDRPNKRNKTSHLEQAAEPSLTKQDVDDLWASFNSEPDPYAAPSASTTTATTSTATATTTSTPHNDSAKPSSSTTKSSQPKTIKIQVEYKFVGETVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M1F3</accession>
    <name>A0A2X0M1F3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C003g02388 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C003g02388</name>
        <name evidence="6" type="ORF">BQ5605_C003G02388</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the APC3/CDC27 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY40508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M1F3"/>
    <dbReference type="STRING" id="796604.A0A2X0M1F3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF13">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="732"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="800"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="834"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="902"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="270"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="436"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="496"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="444"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="583"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY40508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="961" mass="103573" checksum="F88C29E328956F6F" modified="2018-09-12" version="1">MASTNIHAHAHNPATHLNAIPTTAMNNLTHRQSLLRQLVLSSLPHSAVSALFFAERLHALDPSTEPSVYLYAFVLAHNQRHHEAIWLLRQPVSFHPLEHTHPVDPFNSTSMPNPIAGYHASRRWPVHMRLSRPSIDCSLRCARLYASTCSKVDRHRESRDVLAKIVSTTQPLVQPDPATEAALHAAVSLPSISSSSSDPTYVIDLEMARLARQSGEHERAIQSYRKALDKNPWCWEALEGLCAEGAPPDPDVLYPPRPIRTVRSAPASIPISPMLSSSGNNNAHAQPSRPPLSAHPSHPAPLGPSQSSTINSAFTFNNAAANKATSSGGFFTPGDAAVSQVGGGAGAKGKDAKPERGGLFGFGPGVAAVSSIWRKGRAQMAADISETSIEDSSFDTSFYPQPFNLQNNAHVHASSSNSLFTPPTVVSIAPNTVAPGVKRTRGGAQAQTLNAAPTALTTPNNGGDEDMRSAALTNAAPSKRVARGALSIPTVTVETGSKYRRDGSTGANAAPATRRSSRLSRDQGSSNGITGGGSVSMALTRSQLSANGGGAATTRSAAARDKKRNKAGAGPSVLSDAGSEALSPPSITSSSPAPSSPGATMHPPPTSTSVQPASILDAATQEAEDYVAHLLRCFASAATNAAKFESAKTIEALLLLPVEQQRTWRCLVGIAKAHLELLNYEKAEKAFSQARQVAPHLLDSMELYSTLLWHLRLSTSLSFLAQDLMLIAPRSSVAWIASGNVFSHLEDHGSALQCFKRAVQLDPNCVYAYTLSGHECVMLEEWETALVFFRDAVRRDRRHYNAWFGLGNVYLQTGKYRLAEYHFRHAMAINPTNATLLACVGSVLEKLGKRKDALEIYEKACLLAPESAAVRFKRVRILLHFKRYEEAEADLLTLKNRAPNEFNVHFLLGKLYKVLGRKSEMLKHFGMAQDLEPRTASLIREQVEKTSASGGRERGMEVDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M1P3</accession>
    <name>A0A2X0M1P3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BQ5605_C002g01111 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C002g01111</name>
        <name evidence="11" type="ORF">BQ5605_C002G01111</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY30054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M1P3"/>
    <dbReference type="STRING" id="796604.A0A2X0M1P3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048250">
        <property type="term" value="P:iron import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000029">
        <property type="entry name" value="Solute carrier family 25 member 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758:SF4">
        <property type="entry name" value="MITOFERRIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758">
        <property type="entry name" value="MITOFERRIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="16"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="112"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="203"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY30054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="309" mass="33186" checksum="A0A452CA254DB614" modified="2018-09-12" version="1">MAAMVEEIDYEGLNNDSLAINMLAGAMAGISEHAVMYPVDSIKTRMQVLTTSPGAMYTGMSDAFTRIASTEGTKRLWRGVASVIWGAGPAHAVYFGTYEFTKELAGGNQGGYSFAATASAGATATIASDALMNPFDVVKQRMQIHGSTFRGVGECFRSVYHAEGLSAFYVSYPTTLMMTVPFTAVQFSTYEFIKDRLNPTGHYSPWTHVTAGGIAGAVAAAVTTPLDVCKTLLQTRGTSDQAAIRNARGMLDAAKIIWERQGASGFMRGISPRILTNMPSNALCWLSYEGFRFLLKGRAAASTKRNEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M1T9</accession>
    <name>A0A2X0M1T9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C002g01151 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C002g01151</name>
        <name evidence="3" type="ORF">BQ5605_C002G01151</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY30410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M1T9"/>
    <dbReference type="STRING" id="796604.A0A2X0M1T9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY30410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="341" mass="36794" checksum="86515AB433A7E766" modified="2018-09-12" version="1">MPAPGRSAPASPRQPSRIPTRRSSANTPPSAAGSSTTPAAIAANPASIGSPSRPASSSTSHGTLAHSTTKEAGRRAERSRSVSHPQRLSHEASFEANMAPGTIDVISGSPHLSPSPPPETRERLGMSRSAQKYMSSSSSSPKLSQIRNVEEGLRSPSSLVYPAPIRFPSHPSRPSSSTTTSQPRRSTCPVRPKLERPLSTCYTSLPVPPPRTPGDDDEEASPSQQWSGWLWGSNSRHHQQQQQGADSLAERGTGGSPIKRSSEREPLLEYSTATSETRSREGLPKVTRQCLIAEIKCYGKYMLPPIIVFVGLVMSLALVLYAHARSRQSDTDVHPFYLFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M279</accession>
    <name>A0A2X0M279_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C002g01281 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C002g01281</name>
        <name evidence="9" type="ORF">BQ5605_C002G01281</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY31937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M279"/>
    <dbReference type="STRING" id="796604.A0A2X0M279"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2190:FF:000001">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000002">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000001">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000011">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051264">
        <property type="entry name" value="FAD-oxidored/transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716:SF1">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="8">
        <location>
            <begin position="110"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="24"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY31937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="561" mass="60917" checksum="F6750C885988B9E5" modified="2018-09-12" version="1">MAARLTACATRTIATPSLAFRSRNTVPAGLPSSSRSLQRQFSTTRPTLGGAVPPRGDYKQLNAEDVSQFASMMSNPTASLMTTIAAPNGEWSSAASDDLEGYNKDWLDKYVGRSAIVVKPKSTQEVSKIVAYCYKHRIAIVPQGGNTGLVGGGVPVYDELILSTEGMKEVRHFDEVSGMLFRTGILTCDGGAILESLSNYLHPKGYMMPLDLGAKGSCHIAGNISTNAGGLRLLRYGSLHGTVLGLEVVLPDEKGTVVSVGMPGSKGGALRKDNTGYDIKQLFIGAEGTLGIVTGVSILTPRISEAVNVAVLCVPNFEGVQRVFQETRGRLGEILSAFEFWDQEGLELVLHHTGQKAPFEGTPEGGRAFYVLIETSGSNKDHDDEKLGGLLEHLLEKEIIADGVLAQDDAQLLSLWSLRELMPEAAGKLGKVYKYDLSMPVKDMYSLVEEARIRFKEHGLDKDGSIKQTIGYGHIGDGNLHLNIVANKWDERIEEIIEPWVYEATAARNGSISAEHGLGLMKAPYVGYSKSDESIALMQQIRKLFDPRRILSPYKYLPPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M3T4</accession>
    <name>A0A2X0M3T4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Proline iminopeptidase</fullName>
            <shortName evidence="8">PIP</shortName>
            <ecNumber evidence="8 10">3.4.11.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C001g00590</name>
        <name evidence="12" type="ORF">BQ5605_C001G00590</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8 10">
            <text>Release of N-terminal proline from a peptide.</text>
            <dbReference type="EC" id="3.4.11.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 10">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.5" evidence="8 10"/>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY47913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M3T4"/>
    <dbReference type="STRING" id="796604.A0A2X0M3T4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005944">
        <property type="entry name" value="Pro_iminopeptidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01249">
        <property type="entry name" value="pro_imino_pep_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43722">
        <property type="entry name" value="PROLINE IMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43722:SF1">
        <property type="entry name" value="PROLINE IMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006431">
        <property type="entry name" value="Pept_S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8 10" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="11">
        <location>
            <begin position="62"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006431-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY47913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="345" mass="38554" checksum="78CA2348AD82CFE9" modified="2018-09-12" version="1">MLPVLFLHTKRAFSSTSCRSLSNAAAAMTAYPSIQAYKSEMLDVDDTHSISIRQYGNPQGVPVVHIHGGPGGACSDRDATRFSPSTYRIVLFDQRGCGESTPPSCLKDNTTQHLIEDIETIRKHLGVGESWHVFGGSWGSTLSLAYAQAHPKSVKSLTLRGIFTLRKEELDFFYQGPGTSFLFPEYWDEYVSVIPEAERGDMVKAYHNRLTGDDEEERAKAGKAWSTWEMSTSRLRVDPDYIKKADAPGFADAFARIESHYFVNEGFLPQGELLKKENIDKIRHIPTVIVQGRYDCVCPIKTSWDLHKAFPEAEYIVVPDAGHSAIEEGIEKALLEATDKFSKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M4D3</accession>
    <name>A0A2X0M4D3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g01892 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g01892</name>
        <name evidence="2" type="ORF">BQ5605_C003G01892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY37812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M4D3"/>
    <dbReference type="STRING" id="796604.A0A2X0M4D3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="1">
        <location>
            <begin position="116"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal-type protein kinase" evidence="1">
        <location>
            <begin position="390"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY37812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="595" mass="66439" checksum="23893FD7022E07C2" modified="2018-09-12" version="1">MDEARCSKAMNKYFFDTPSKYEGKTPKPTQKLGTEAAMKEMADAIKDLTGDRRLVGCGNLGSYIELAPDRQGQEKTPDAVILTHAAVAAAPDLPLVWAQLEHPTSMEGTPPLPQRAYSQIAVVIEVKKSDTKSAEARNQVLRQLHMICTTALRAHAIGVTLCGDLLQVYLVNACRVFTTTPRKCGQEAVLLRRVLSHLIELDDDGLGMLASTNEFDDIYGNFVVSDKFLPPRAHDFDCSGRATSAFRVTVRHAPVDPTSISLPTSVTEYAMTVAWVDFFCLDDAITLRRKMHAASRIDTEGLCLSAVIYRDDFRTLPIFFGEDESFDDIQPRALEVVFHQQCCEELSTATTTKELAQAVLGVVKGEHGDQLGGLAFAVPSRHAHSHDNAGHRNLYKLGYIHRDISKDNVVIDRDGVGVLIDYHVAVPHDRPCTELQHKTRYGTWPYLACSILAQPNEPLGVVHERWHDIESLFYVGMEISFCEPYKGNEEVFVMTPKGETIWRYWNSPEADLVYALKDRLRMDKAYRSLLEGCAHQFTGIQLLLDILRRNCGLDSRLLGLEVAMEEAQLGELWGPSKAMSYESIISDIEQLLPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M4L3</accession>
    <name>A0A2X0M4L3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C003g02043</name>
        <name evidence="10" type="ORF">BQ5605_C003G02043</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the importin alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY38523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M4L3"/>
    <dbReference type="STRING" id="796604.A0A2X0M4L3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000021">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.690">
        <property type="entry name" value="Importin-alpha, importin-beta-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032413">
        <property type="entry name" value="Arm_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036975">
        <property type="entry name" value="Importin-a_IBB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024931">
        <property type="entry name" value="Importin_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16186">
        <property type="entry name" value="Arm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01749">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005673">
        <property type="entry name" value="Importin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51214">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IBB" evidence="9">
        <location>
            <begin position="23"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="146"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="188"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="315"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="357"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="64"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY38523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="576" mass="63331" checksum="3963B4D45C794D0B" modified="2018-09-12" version="1">MHFALSSLRDGADDADADALSFAQWTCTPTETLARSNSRRNAYKNKGIFGAEELRRRREEAQVEIRKQKREESVAKRRNLVVAPNSGSAADSDDEGGNDSSFSDMPDMIRGVFSDQPDQQLDATTRFRKLLSKERNPPIEKVIECGVVARFVEFLRNEHSMIQFEAAWALTNIASGTSEHTQVVIESGAVPVFIELLSSNVLDVREQAVWALGNIAGDSPKCRDYVLEQGALRPLLALLNEPHKMSMLRNATWTLSNFCRGKNPQPQWELISPALSILTKLIYSLDDEVLIDACWAISYLSDGSSDKIQAVIESGVVRRLVDLLMHHSTAVQTPALRSVGNIVTGDDLQTQVVLASGALPALLSLLSSPKEGIRKEACWTVSNVTAGSPAQIQAVIDANIIPPLINILQHADFKTKKEACWAMSNATSGGLQEPSQIRYLVSQGCIKPLCDLLTSNDNKIIQVALDGLENILKVGEADKAQHNGTNQYAVFVEEAGGMLAIHNLQHHENLEIYKKCFHLMDTYYPEDEGDDTGIQAAQVDSQGAFAFQSDLAAPQSGFSFVSPRKRSVFIDPTRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M568</accession>
    <name>A0A2X0M568_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="22">BQ5605_C006g03836 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">BQ5605_C006g03836</name>
        <name evidence="22" type="ORF">BQ5605_C006G03836</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY54072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M568"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0229">DNA integration</keyword>
    <keyword evidence="18" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="16" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="15" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="16" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="17" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="21">
        <location>
            <begin position="402"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="SGY54072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="712" mass="79835" checksum="0032FB40252D5DC2" modified="2018-09-12" version="1">MSHLIHLTSVYEMWDTLRGLHSHGRPSRTMDLLNTLAQPYSGDISFKEFVNKVKITMTDFQNLGAPFPHWLFAGMLVWSLPAQYDSIVGNLASDIDIHMDWKTFYPKLLMNVEMADSRNKQKESLSARIVDNTSLVARVSTTAQKDYSKSCCSRCKALGHERGWRLCPSRNKDASAPASSDSNLNVAAIGVDESALMTYIFPYSRTMPRFPWIIDSGAKVHCVGDKSVLSDVVSEPLKIYVADQSQIESPGHGSVTFLTSYGARITIKRVYYMPGAQCGFISIDRLLESMTYAVGPQSNLIFSIRGKSILRSLPGRGFVMDAAPVQPIMSSSPPSMVGANCLTGTCTLMEAHRKLGHQSPAAIVLAVKSGAITGITLKDKKVTPCFSCIQAKSKQSPFSNKSTEAPHALYRVFIDLGFVKHPNHHGNTIYLAIVDQYSTAKWTIVLKDKRAETIIEAWSKVQAESERQTGQKIKRVRSDNGREFDNSLFRALLEKQGIIVEFTAPYTPEQNGQVERLNGSLMGLVRSMLLDSGLPMRFWSDALAVATFVLNRRPHPRIQGKTAIEVLLGKKPSLAHLQPFGSTAFVHVPKERRSKLAPRSIQGVFIGYSGEYNYRVWVQSSKQVYVSRHVTFLETPSVVTLSQDRADAFDPMCCRLHQLHLLWIQLYRIHSLLRWFQLELVNRGGILQSFLVRMMTMTTTMDLITIMMQRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M6E5</accession>
    <name>A0A2X0M6E5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00007 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00007</name>
        <name evidence="2" type="ORF">BQ5605_C001G00007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY43265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M6E5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY43265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="501" mass="56494" checksum="7B2686CF2BDFE6EA" modified="2018-09-12" version="1">MARGRRKKWTPKAHAPPPISEREARLQSRRTRLQVLNLPGAAASPSAFSAPFPLEPTHIHELSSKPHWKSSLEDGFEDVEPAGSSQQASRTTLTRPIHIHRSDCEGCVLLDLSPGSEKKLYEPQIRQRVDYYSSHRWSFRAVTQLRHQHISTKGGVAMGPDGELQWHQYDGLNPMGSIAHLATELVPDLRATASYSWRNPDVNAEGLLLPTVAMARQRYEVMGLEEGVVEEGGQAARQTFKKFWEASSARKYQIDKLRILEKVRHSLFEDEYRAHKSVMVKLRCPTCAAGGLCGTPVAFTQNLIRYLQRGTKDDMMHHMCERGVTKDLRADEFKKLSGAEAWRLVKVHDYGVHRDGLGARALAEVSYPEESVNFQLVPGNKLAWPFSNAKPLAGSKNREIYVSLQVPTETLLKKTWGTNASLVKTFIKDTKKTNQASEPASFSIAKKLAAERYADNDSDEDGPVRHHYFPMLQKWYLFAMPLVQIIQSEPEEVTGWAYSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M750</accession>
    <name>A0A2X0M750_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C001g00297 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C001g00297</name>
        <name evidence="3" type="ORF">BQ5605_C001G00297</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY45544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1061"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="449"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY45544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1854" mass="203285" checksum="E37B6899A4046622" modified="2018-09-12" version="1">MPDPPGAQAPPPDNPLGGNRASDHESLNTLTREPVTGGTANPPAWSTEATQARLDCEKVMQNTFRVLGIVPSGKSTRRLMVLMHDASTPPSQAPLLARAAQRAVRNDAAPASNVIRVIMDGPGSPRGPVQIALRKHFGLAETPFMFARPEGVVLDPEVEKLFSKCVKLNPIVTKATKRFPIARHMYELVFESDQACLEAAAAGPFSHHGKEMVTELPSASPLNHVVQVRFTLPSSSSATPASVLRQSLDDALTLSFGRAGRTQGYTLMQLQRGLAVDPNGDPMAMTEDGFHCAYLRLHADLFQGSTETQKAALNAALPQEIEILGAKYGLRHEFETHYCAVCDRAGHQWGACRKPVSTPATAAPVPGASTSTSTTGFRVAGKNGKHGGPAALNSRASGTNMIQLGPRANPAGAATGNKDDANDDDGGGESVASTEPEGGDTGKETLTRATTGPTKETQTTTAAPVSTPTSPSPSASAPASPLSGGTSESSATSTTSIASTSPRRLRSSSAPGNRRVTRAGSAMILGASGGDGSGGNSSGVNQVKIIRYLKTLRPAPAAILLQEHHLGYNASREGFESAWPGACIRFTPHVLTLIPDGSPLAGHLLSSTPVVFAGAPRFDGRILRSVFRLEELDVEIINMYAPVQEDDRRDFFGLLHFNAPRPKTLRILAGDLNDCPDVSVDRVSITDRAWTPVSHWQTLLSKIAFNALDTVRHVHSCTPAFTRPHYRGRGEERKICSWSRIDYILVQCSWANRLLSASTLFDAPCSDHRPVVATFALPTSNADAEPPLSLPSTSDFISRLNPTVFDDQDFVASIPGVVDEVYRRLEGTAPLGDVYDAALRAVAVAGHARYRSTRADMRRLRAESQSVMEALEARGEHMNEAERDAYAFAKSRLDQLAVKEAQWLRIRAHVPSVDSREGQSASIRTRLNRRSRQTSIVSLEDVDGTETVDMQEALGIASRHAQSLFTPDPARGDPTNARRSLLGPIRAAKCYDDDRSDPTFGRRLPRQARVALDEPFTLLEVEAALKKTDSGRSPGPSGIPYELFKALPTYFAPKLLDLFNSIWEGGKMTASLAEGLVRLLPKNKPGANLKSLGAYRPITLRETTYKVLSKVLVARLNGVLGELLPPAQHGFMPSRRSADAGSHLTLLLEKLKSLGTEVFPEGALLSLDQQSAYDRVDHAWIFDVFEAFGFGERFISLLRALYDPETLGVRYLINGFPTELVRLLCGLGQGDPLSCPVWNITFQPFLDALVRRGIALDLQKVWPGGPRAQLTHLAFADDAVVVVESPAALSKLETLSQTWYEATNGKTNTDKTLVLPLGPNWLRDETAQALPTVQEGESFKWCGYAFFRHGDSKLFWTHVLDRIKAKTRAAGDRTLSPSGKVFYANAHIISTVLHVLSFDIPPQWFIKAAETALTDFVWGGAGRNTVARDFVFQAREDGGLGLISIGDIVHSVALRFWDAVAGSNEAIWAPLARESWRSLVAATRDFSPWGFFSSTARVEKLYRDSTRWGAVVAAARVTLPTIKSELLTLPELLSLPPRLPLLYAEGAKHAYDDADAVAKFAQIADLYWRDEGKGWALVGHRRGFWQHSKEPALQHEHVWSRVGQLLKAKALLPKTALRPARIPLKEAPRPRCFNFFGLTRPFTIRKLRRLVNVVRFPGREDRVKRFRDGTSQSDRKRFWRWLHDRFASAVEQDTHWRLMYDVTPTRKRQHTQGHASSPTCLFCGNDAAAIETVSHYFFECAYSTSFWGGVLRILFDKLGIEDTDVDPSTFTPEQLTMGLPLLRGRGRTTSRWMWVRLACAIGFQRLHLLRWRVHQRFELDKVVAPPSLPSALRAFERDFLSRAGFVPGARDWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M758</accession>
    <name>A0A2X0M758_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C007g04440 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C007g04440</name>
        <name evidence="2" type="ORF">BQ5605_C007G04440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY60488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M758"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY60488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="97" mass="10788" checksum="E375C73EC56D2BFB" modified="2018-09-12" version="1">MPRKTIALEENLPDRGTARSAPLSASALPHRRDQSNLRLQPLASEDDPNDQEVSPPCTCDHTLARKVIMYGYEALQITFCASEPPCLIRPFESDLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M7D1</accession>
    <name>A0A2X0M7D1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C001g00679 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C001g00679</name>
        <name evidence="1" type="ORF">BQ5605_C001G00679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY48678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M7D1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY48678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="55" mass="5989" checksum="DD85EA04035A5FAD" modified="2018-09-12" version="1">MIGITLLVVSRVRGLHGSSCGPPGRLWWMYQHTVVSAAPACGVHVPIRSHVQALW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M7P4</accession>
    <name>A0A2X0M7P4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C007g04660 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C007g04660</name>
        <name evidence="3" type="ORF">BQ5605_C007G04660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY62166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M7P4"/>
    <dbReference type="STRING" id="796604.A0A2X0M7P4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37487">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37487:SF3">
        <property type="entry name" value="CLEAVAGE_POLYADENYLATION SPECIFICITY FACTOR A SUBUNIT N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="361"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="427"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY62166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="452" mass="47844" checksum="B830B9E513BCFA5B" modified="2018-09-12" version="1">MLRASLGGLHSGFRFDTPHRPTDTRSYTTLSSLVYAPSRSFAAHRSPFPWPVHQSPVANRPAAAVAVARTIPGRLITMVSQHQRPRPRTSPLLCLSLACASVVEAALTLQAPATLTTCQPASFNWTGGLPYYTLNVGPQGNTNLEQYVLTTKAYDWQVDYPAGTIVNVRLDSGAAYAPAYSYSGSMIVQAGTDNSCVPASHQNLSTSATLTNPTPLSAALKITFTTVPTNLSSCTSATWAWTGGSAPYTVTFIALDSAGMADTFTTNSPTYTWAPTYPGGVTLLMTVAPGSYVNSQQAFFKTMYIYNGTDSSCVTQQHLQNATRTSPPPYVAPVVSSSTRSPKPTATAFVSGNRATVQNSLSAGAIAGIVVGILGLGLIYLSFFIIRRRQQRNKMRFGNDGTPSSLMRLDSIEVEQEQRPVLGGRQGPSTGASGSSGAARPAGGNAPSVLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M870</accession>
    <name>A0A2X0M870_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g03805 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g03805</name>
        <name evidence="2" type="ORF">BQ5605_C006G03805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY53818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M870"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY53818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="174" mass="19334" checksum="B228DD38DC751EA7" modified="2018-09-12" version="1">MMEGVYSERPDMAHFFSPDAKAHSSGRPVKKIIIKRAIGWWKREKAKYRKAREQLGETGQGLTSPADLETINDPADMLQLCGQGNPHLGKTKTLNLDSDGLHEITSHLEGATGDHNMELLDNDSTTFPTSDWPVSETGDLITDEARSSEGEDIPEDTEEEEDDHIVSIHALRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M881</accession>
    <name>A0A2X0M881_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C007g04870 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C007g04870</name>
        <name evidence="2" type="ORF">BQ5605_C007G04870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY64100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M881"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY64100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="174" mass="19986" checksum="81613298CD7539C7" modified="2018-09-12" version="1">MHCRLIARLTSKEYEFISAGPGSDQHASWLRRTTQASQAERSSPYTPASARLQAEIRAEWNQYFTDANFRVFCCLVCSERVFGHEAQWVAKSGLKCRDRGILEVLTDVHWRSDLRPTTYDFKEWRAAIIDPRGLHRRNDLEGQPIYFATDESSVQCSVCPGCYQSLFTCKSCAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M8S5</accession>
    <name>A0A2X0M8S5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C004g02800 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C004g02800</name>
        <name evidence="9" type="ORF">BQ5605_C004G02800</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY67707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M8S5"/>
    <dbReference type="STRING" id="796604.A0A2X0M8S5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF138">
        <property type="entry name" value="DEHYDROGENASE PKFF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016133254" evidence="7">
        <location>
            <begin position="28"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="8">
        <location>
            <begin position="327"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="646"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="579"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="622"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="578"/>
            <end position="579"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="623"/>
            <end position="624"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY67707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="665" mass="71696" checksum="71E1B0084CDAC087" modified="2018-09-12" version="1">MTARVTHPARITIAVTLLLSCFTLASAKITQEKRAIPLPGATYDYVVIGAGTAGATIAARLAEDPSVTVAVIEAGDGLQNINPLAFIPGADVLGVGADSSDKQILNDWAPITQPQRGAGNRQLHYARGKGVGGSSIKNFMIYQRPDRTSFDAWEQATAGQDSPGWTWEDVYPYFTKSVAITPANNEKRGAQYTPRYNPAAFPQTDSSQAPLTLGYPNFAFEYGTTLAAAYDELGYPAASDFSSGTLNGYAYNPSTIDASNGHRATSQKFIKNAQNNGLSNLKVISSAMVKKINFDSEMNAVSCTYTTLFGAFRTTVSARREIILSAGAFQSPQLLMVSGIGPKAQLSKFGINQLVDLPGVGQNLQDHVFFSPSYEIKNHIYNLGGETRLFKLLLAGASALFTNSDSLTNPVADHLNWGRFNDSFFESHPEAAALSNTSQYGSLWPHYEFLAAPGLTKDFSNLFTLNSALASQNPPRFFYSLLGALVAPLSRGQYYETPCSGSLASADSSVYPKIDPNWITHPGDQAVAIEIFKKIRRIFNTEAFRAVRANTEEYYPGLDVQSDADILKTIQASVQTVWHAACTCAMGSRSSGGVLDPYLRVYGVNRLRVVDASSFPMLPPGHPQSSVYMLAERAADFIRATRTGAITPPSVTMPEGDSGSPFTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M9K2</accession>
    <name>A0A2X0M9K2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C004g03013 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C004g03013</name>
        <name evidence="2" type="ORF">BQ5605_C004G03013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY69431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M9K2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY69431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="85" mass="9779" checksum="9C43E5F565FEFB64" modified="2018-09-12" version="1">MSHRSSKTAFNLASRAHRRQAPEVRRPPRSIVVNCLQRPKAFLKTIRPIKKQVAKLGIPAEQYLQISQVQESPIRIRSERNVGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MAP0</accession>
    <name>A0A2X0MAP0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C005g03455 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C005g03455</name>
        <name evidence="2" type="ORF">BQ5605_C005G03455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY75889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MAP0"/>
    <dbReference type="STRING" id="796604.A0A2X0MAP0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY75889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="281" mass="31232" checksum="CAFECA3B6E637A00" modified="2018-09-12" version="1">MWFLRAAECARAQLLYAIHLHSTSSALPYVSRHLHRVFSHSSPLHRATYLALRHDRHTLSHAVRYPICTLAVVHSLERLACAVGTRPLRCSELPRRLVKHLNPQQTDSSATLDDDKFGLIAYLLEHYGASPNSKNGYFLARAVLARHLPLTKLLLHYGADPALKDGWAVMVAIGMGDLDTVKLLLDEPTPTVDRVETSGRDKSSSSHTRSDSLPPQAAFLARHSIGTTPLPRPSKKRCKVSPRCCATSEMLEAAVKAQHWHIVDYLRTQGALPSLEVLKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MBV0</accession>
    <name>A0A2X0MBV0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C004g02709 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C004g02709</name>
        <name evidence="5" type="ORF">BQ5605_C004G02709</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY66817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MBV0"/>
    <dbReference type="STRING" id="796604.A0A2X0MBV0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00677">
        <property type="entry name" value="S15_NS1_EPRS_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_B">
        <property type="entry name" value="Ribosomal_uS15_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_uS15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00952">
        <property type="entry name" value="S15_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15, BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321:SF26">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY66817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="309" mass="34973" checksum="EBD048241933CEEB" modified="2018-09-12" version="1">MFARIASRSSRVLVPTSNPALASTSTSTSHSHPFSSTSHASESKRLRKARLVRKAHIEKKALLVQSHLQNQPDPVLGYNKKIGGDLWERCLLKRTLLDREVLWEGVKRGSIEQEEQEGKERKLQKTTVERHYNFGLNERDVKLLGQSLPNVSMMRDVVTASGRLASQELNENRLAKAEQREMDKKDKLMRILDLGNAGSKAIQVENVRRIVKAFGKDENDTGSPEVVAAILTARIHSLLTHLISQPRDIHNRRSLRAMIQDRAKALKYLKVTDVRRYEDCLLNIGVEPRAVEGEVVVTKKALRELIRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MC21</accession>
    <name>A0A2X0MC21_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.256</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">BQ5605_C008g05116</name>
        <name evidence="15" type="ORF">BQ5605_C008G05116</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the third and last glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(2)Man(9)GlcNAc(2)-PP-Dol to produce Glc(3)Man(9)GlcNAc(2)-PP-Dol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>an alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate = a alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29543"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="Rhea" id="RHEA-COMP:19512"/>
            <dbReference type="Rhea" id="RHEA-COMP:19522"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:132522"/>
            <dbReference type="ChEBI" id="CHEBI:132523"/>
            <dbReference type="EC" id="2.4.1.256"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:29544"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the ALG10 glucosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.256" evidence="4 14"/>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MC21"/>
    <dbReference type="STRING" id="796604.A0A2X0MC21"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106073">
        <property type="term" value="F:dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016900">
        <property type="entry name" value="Alg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12989">
        <property type="entry name" value="ALPHA-1,2-GLUCOSYLTRANSFERASE ALG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12989:SF10">
        <property type="entry name" value="DOL-P-GLC:GLC(2)MAN(9)GLCNAC(2)-PP-DOL ALPHA-1,2-GLUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04922">
        <property type="entry name" value="DIE2_ALG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028810">
        <property type="entry name" value="Alpha1_2_glucosyltferase_Alg10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR028810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SGY79379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="478" mass="53775" checksum="4935463F8AFF13B2" modified="2018-09-12" version="1">MLSRKTNGALTAAYHAINLLTFYTVLKNVGPTPYMDEMIHIPQARAYCRGDFGFWDPALTTPPGLYLISAIPAYLIAPLRPYLCSTAGLRAVNFLFLSYLPYVVSGLLETLQENTPTPQKIKGHEKAVKTTKLRGLSLSSEAIFIATFPIAWFFGYLYYTETGSLVLVLLSQSFALEGKWLKSALVGAASLTFRQTNILWIAFVSASSIIRVLSRQEAKRPLKNPLLANTNLAISLVDHGLRFIPQLLPIILSYLPVFLGAAAFIKWNGGVVLGDKANHVPTLHLVQPLYFFAFTSFLAPYTLTPSNVSRSLRNLLGSPRRIVTSTLATGAALYCIRYHTILHRFLLADNRHYTFYVLRRIVNRFPAARYLLAPVYIFAGRLFLDVLIEASSFRLLEALGLALTTLLVIIPSPLIEPRYFLIPYVLIRLHIRPQTQKAVWMEGLLYGLVNAVTMWVFVQRPWMRITNEGVVDVARFMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MCJ0</accession>
    <name>A0A2X0MCJ0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Eukaryotic translation initiation factor 2 subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C004g02929</name>
        <name evidence="11" type="ORF">BQ5605_C004G02929</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF2B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY68910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MCJ0"/>
    <dbReference type="STRING" id="796604.A0A2X0MCJ0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04452">
        <property type="entry name" value="S1_IF2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1130:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000015">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.190:FF:000002">
        <property type="entry name" value="Translation initiation factor 2, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1130">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.190">
        <property type="entry name" value="Translation initiation factor 2, subunit 1, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044126">
        <property type="entry name" value="S1_IF2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024055">
        <property type="entry name" value="TIF2_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024054">
        <property type="entry name" value="TIF2_asu_middle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011488">
        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07541">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110993">
        <property type="entry name" value="eIF-2-alpha, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116742">
        <property type="entry name" value="eIF2alpha middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="10">
        <location>
            <begin position="12"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY68910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="299" mass="33809" checksum="2C4C6CB818D59CE5" modified="2018-09-12" version="1">MRFYESRFPEVDELVMVQVKQIQEMGAYVKLLEYDNIEGMILLSELSRRRIRSIQKLIRVGRNEVVVVMRVDKEKGYIDLSKRRVSAEDVIKCEERYNKSKTVHSIMRHVAEKTGTDMDAVNDLVAWPLYKKYGHAYEAFKLSITEPESVFGELNIPDDIMEELRANIARRLTPQPVKVRADLEVTNFAYSGILAIQEALALGEALSTSEIPIKIKLVAPPLYVMVSNTTDKQGAIDLLERAIETIGERIRKEEGGSLNVKMKPKAVSETEDMELAALMARVAKENTEVSGDEDSEGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MCK1</accession>
    <name>A0A2X0MCK1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C004g02939 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C004g02939</name>
        <name evidence="1" type="ORF">BQ5605_C004G02939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY69003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MCK1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY69003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="111" mass="12367" checksum="D6C98A767923DBF7" modified="2018-09-12" version="1">MLPVALVNEHWQLRRAERSLSSWPPSCRSPRETSNRDQTAKLYESSITVIALLAKELPAIPQHIVYQVLAAYVYSKASRGNLSVVGVRITPNGELPSSTLTRFPYDAEADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0ME81</accession>
    <name>A0A2X0ME81_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C005g03521 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C005g03521</name>
        <name evidence="9" type="ORF">BQ5605_C005G03521</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in the regulation of membrane traffic through the trans-Golgi network.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY76848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0ME81"/>
    <dbReference type="STRING" id="796604.A0A2X0ME81"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14235">
        <property type="entry name" value="GAT_GGA_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16998">
        <property type="entry name" value="VHS_GGA_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.160:FF:000005">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.2, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000008">
        <property type="entry name" value="VHS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052653">
        <property type="entry name" value="ARF-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47180">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47180:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="7">
        <location>
            <begin position="27"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="8">
        <location>
            <begin position="196"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="392"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="395"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="421"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="457"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="468"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="479"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="514"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00053552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY76848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="579" mass="62948" checksum="20090605227A383E" modified="2018-09-12" version="1">MSSHHSSWNVSAYATTKETLVAYIDRACDPLLREPNLSLNLEIAELINHKKANTPREAAVELVRLVNHRNAHVAMLALHASQPSRLLDILVKNCGYPFHLQISTKDFLNELVRRFPERPPVFAPPPMAKILQLVHEWKNTLCVHSKHKEDLVHIRDMHRLLSYKGYRFPDFDKRAHSVLNPSETLQTPDELEEEDRAAQAAKLQELIRRGTPKDLAAAQELIKIMSGAEPEKRPDYEQQVQKELDRIQQRILLLNEMLNNAKPKERFVEGDAYDQIAQKCRHVQPKIQKWIEESVENDPGAIDRLLMMNDLINNILKRYEAFKAGDRTAVAEIDPALGPSGGKPSKKVETSLIDFDFDEPRAGASNFSPASSNPMDDLSALSGLSLGVGADPSSAFASGPTSAQPFGSQQGGQQPKVDPMSFFNSPSSSSSNTNSPRTLMPTSNNNGMGGGGGLFFSNPTYQQQQHKASSNANGSGNSQPGTSNSPISWASPSTSNAIPRASTPSQSGVIQLGSGSGQGGNVSGGQSSLAVSTGKGGFGGQAMYGNSPPLPQLPMEANQEGGQEIGKKKDAFEDLLGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MG69</accession>
    <name>A0A2X0MG69_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C035g11446 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C035g11446</name>
        <name evidence="2" type="ORF">BQ5605_C035G11446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000064">
        <property type="protein sequence ID" value="SGY98154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MG69"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY98154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="506" mass="53677" checksum="6D4AAF8BDF13DA95" modified="2018-09-12" version="1">MSNVKPHETTTAALKDSKVHGSGSGVTSTGTLSAGAGATTSSTSSATSATAGTAASTSPASGTTTPQPAWMKHYEKFVQSAVPNAISSRLPSSGTVAQSLDQTQAKLQEITTTSKASLDKTWSVGKTRYSEWKLATDRKMNKEQFFKNAWSVTNETQVVLNVSLNQVGPLMYQVLLPGETFERRVPNVWYALSIRPWTSPETEYSSWSVAWPIIAIAGPVSAAASLIAIPFVALAAGGTALASLTGFGSSVATGVTSVGTAVTSTAASAAGLAARAASLPGGSKVRGKLVDAAKGTVGTRGEVVIPKVVKYLTTSAAAGGVFKGAEAEHWKVEGAKSKKKVAEVDVTGLDLQKVLRCHTGKSKVDKQLVAAFEHLHFKKHYKTATNPVLRITGGPELEERGEKQVLVFYHFVLEQAIDIVVEPVSVEEVPPTQSEEALVKDARVVPTLEEAEQVSKDVPVHGKGEHPEKVDELVEKVMSEHGDKVEKAKSEAEKTEERKGWFSWRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MH44</accession>
    <name>A0A2X0MH44_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BQ5605_C009g05643 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C009g05643</name>
        <name evidence="11" type="ORF">BQ5605_C009G05643</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY83554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MH44"/>
    <dbReference type="STRING" id="796604.A0A2X0MH44"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000100">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF25">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="484"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="521"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="553"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="123"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY83554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="652" mass="71855" checksum="67BBC839B037C3C6" modified="2018-09-12" version="1">MDTKGRMDPSLARQKELMGQNKPKGSAVHNEKAVGSIHSDDNINAKLENPLAGISLDRLQAMGRAFAHEKGLGEYEEEFAKGAMVAQDPLAFESLPMLDDADKNILRREVTHKWDHPKQLYMLVICCSVAAAVQGMDESVTNGANLFWAPQFGLETAALLPNGQVNANAGKNQWLLGLTAGAPYLACAVLGCWLTSPLNRFFGRRGAIFITATVSGLACIWSGVTNSWPHLFASRIVLGLGIGAKSATVPVYAAETAPPLIRGALVMQWQVWTAFGIMLGTVSSLIFFRVKDPAHITGLNWRLMLGSAGLPAFFVMAQVYTLPESPRWLLSKGRYADAFKSLCRLRHTRLQAARDLFFIHALLEEESTISTDRPAFIEMFAVPRNRRAALASGIVMFMQQFCGINVIAYYSSTVFREAGFSELNALGATLGFGALNWIMAAPAVWTIDTYGRRTLLLTTFPLMALFLLMTGMAFFIPEESKARVAVVALGIYLHCIAYSPGEGPVPFTYSAEAFPLYIRETGMSFATAVTWGWNFIVALTFPRLLGAFKPQGAFGWYAAWNIIGWFLILFFVPETKALSLEELDQVFSVPTKKHAAFQLRATSYFIRKHILRQQVGPQERLYHWDNNSDDVAPRRNLGGAEANAPNVLMTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHD8</accession>
    <name>A0A2X0MHD8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C008g05301 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C008g05301</name>
        <name evidence="7" type="ORF">BQ5605_C008G05301</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY80090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHD8"/>
    <dbReference type="STRING" id="796604.A0A2X0MHD8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PRAJA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710:SF243">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PRAJA-2 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="367"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="143"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="232"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="427"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="266"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="427"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY80090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="506" mass="52273" checksum="F2FC30448FC8154B" modified="2018-09-12" version="1">MSANNESRWWWYFYSHACGQEQPIIRAPEPTCSVCRDSFVEEVEEDSNDDPRDFGYPEAPGTAVNDGPSGFFEAAAAAGQGGAGGAAGAGGVPALRIITQGPDGQARVIQFGGSGTGGNAQGVNAPGGGVMGLLRAFGAAIGAAQGRPNPEPAQPGGAEAQAHDGGAGAAGRAAAQRRRREQEGHDPGDPDDDDLPYGGQRHGGDAQRPRAEGDEIPLRNLAIDAHSAFLGEAFGAPPVDPADDPHNNPFAEGGHNEDDENNNGNTQGGNGAAQQGRGGESGEGSPFDYFIQMLNAFGGGAAVPLASNPRDYAWGEESFQNLLNDLMAHASGRVGPQPAPKEMIDELPRVTVSQAMIDDPTSHFQDCTICQDPASVGDRFLVLQCKHAFHDECLVPWLEQSGTCPTCRFQLVPQPVNGVLPDAAADGAATGNQARTTAAASASNTRTEAEANGSCSGGSNASDGEDTSGLPGSWPDVERSRSASRAAGRARAAEEERQSLPIDDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHH0</accession>
    <name>A0A2X0MHH0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C009g05511 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C009g05511</name>
        <name evidence="2" type="ORF">BQ5605_C009G05511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY81634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHH0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY81634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="597" mass="65806" checksum="81558866FD65A77E" modified="2018-09-12" version="1">MSFAPNLTHRPSVKRSRMHTTPAKPMTRSRTLSRLAKTSIGRISRFLNTGGGGGGGGGGTGTSAVGYTRSRSEPPLPPLPYAVKTAALGPSLYRAESFENVPLADHSISRKRTLKGSISYPVLRSATCASVYECDSEDSRRLGFSTPRSSPPVGYGLKAYRREGQENSGRSSMADDEEELVITVSSRKDARNPKTLKNGSPPSPAPPATPAKSVHWPPRKSSLATEYEYNPNECSSKTKVDPLPTPTSSKFSEKEQRRISVSAAMARAQQRHTTFHERDLETWTSFINDSFGSFDSSLALATFDTSAPVLTIVDFEDDRSGARSPDATNVGDFAPLTTGDGCATSSDPRPLSTTSSLFTSGLHSGQLSTMLDSTSTLTRPISFCLSPKGMGDFSTFPFDVATNTMDESWLFDENRFSFLSYPFRIEGELSRPGDQFEEDRDSVTSEWQGESGADEATEVGEGKKRQKTTISMMLQWCQRPPSEGYLVDREDVEGMDEQDGVGEHEEEHEEEHEEEHEEEHEEQEQEEVLEEDDDETLLDLDGLSDCFDVEIDFEVEMDPTICGAGQSNRPVSLDAYPFRTMRGDDWSGLDRNIRNTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHK3</accession>
    <name>A0A2X0MHK3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C032g11102 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C032g11102</name>
        <name evidence="5" type="ORF">BQ5605_C032G11102</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000067">
        <property type="protein sequence ID" value="SGZ04979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHK3"/>
    <dbReference type="STRING" id="796604.A0A2X0MHK3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="entry name" value="30s Ribosomal Protein S19, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_uS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_uS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_uS19_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="RIBOSOMAL PROTEIN S19P FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880:SF8">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="Ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGZ04979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="87" mass="9800" checksum="DA6119349BEC9384" modified="2018-09-12" version="1">MRPSIAMLARSAWKGPFFTSFPNVAESLRTNTPIRTTARSCTILPNFIGMRFLVHNGKQYVSVHVTPEMVGFKLGQFAPSRQPYKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHW3</accession>
    <name>A0A2X0MHW3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C031g10975 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C031g10975</name>
        <name evidence="2" type="ORF">BQ5605_C031G10975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000068">
        <property type="protein sequence ID" value="SGZ06852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHW3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ06852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="557" mass="59864" checksum="E14D7AC63E4B0E52" modified="2018-09-12" version="1">MPDTFTVPPLPRPPELSQHLTSCTPYSWFNPPPPGNTPDHSTAGRSAAHVGTAFECVARLGGLRWDDPRSPADRVVDAFSGLLRQHRSLLELFEAKMAALGAMRVVPRARTTENDVGFAFAAFLAAGLEGATADLLDHYASITEGDATAASRLYMVQLASVPDQAYQTPANALVLIKRGADVDSQNVVASIAFEYKREAVHHTVATVARTDPPPEIRELDYPLPVGLQNLETERSEGADSVATKAIIHCVHHDCRFFVLLSTGFFQIGEVVKHLPSGAATASDASVSTAAASSSTAAASSSTLHTQTPTSPPSLGTITTEAIVEPAVRPSYSLLVQELARAVEPHPGAVDRAAEVRGLDLPKRSFFVSFIALAFAAVKDVPGPEHATVQQLLGAKLVPSNWCRPPLGSDSDCEDEPDRKARKTSANDIIARRSSRRMVGLASTESSLSTLSPSGLRPRSKAITVVQDRDFLIRTRLTNAHWSTMSYTGTSRVDLVEIEFDIVSSPSYSPVPSRLSSSPSPARDFIQGLPLSDAVLQWLSEDPREELTEELTDARLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MI25</accession>
    <name>A0A2X0MI25_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C030g10782 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C030g10782</name>
        <name evidence="8" type="ORF">BQ5605_C030G10782</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000069">
        <property type="protein sequence ID" value="SGZ08272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MI25"/>
    <dbReference type="STRING" id="796604.A0A2X0MI25"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040153">
        <property type="entry name" value="Rcf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018:SF3">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="7">
        <location>
            <begin position="103"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="189"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGZ08272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="227" mass="24243" checksum="9A8107769ADB0792" modified="2018-09-12" version="1">MAKAVKDVQDERNHQSATVYGGLRAGAIGLGLGAVGSIALQRSGVKAYRSLTLPLKAFALTSVTTAAFIIGADSASREYELAKYSIGSDSDLAREARQGMQLEREAGIAGETQQNRPTLSTRDALIEFGKTHRYGVVFGAWAASMVGSFGYISMTPLSFAQKLVQARMVAQGLTVAVLIASAGLSAIPSTASGESEDQVKRREREESMFRWKKGSQHDLEHSASLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MI90</accession>
    <name>A0A2X0MI90_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C009g05612 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C009g05612</name>
        <name evidence="2" type="ORF">BQ5605_C009G05612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY83004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MI90"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY83004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="118" mass="13035" checksum="85CFE47FA5EBFE60" modified="2018-09-12" version="1">MVRTHSAAAKKKPNTNPTQTDTDTETDTIQTRTDSDTIQIQDTRTGTDTKIPLPQHERGPPTPTPAQPQEHQPERRQDQGTNTAMSSGTRDGPPHTDNVARRVKLELPTLNAGFKSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIN6</accession>
    <name>A0A2X0MIN6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C028g10482 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C028g10482</name>
        <name evidence="2" type="ORF">BQ5605_C028G10482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000080">
        <property type="protein sequence ID" value="SGZ12135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIN6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015985887" evidence="1">
        <location>
            <begin position="20"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ12135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="149" mass="15865" checksum="BE01424CCA6F9350" modified="2018-09-12" version="1">MPSPLHLLLPIASPPLALISCCSFFDLDLDRQPRLHRTVHLLLTSSTSTFASTSGFGVTGGFLVRQSAVQDVMTGINDESTTLSTKTASTGNAAGQVRLEDGDDGAEVGMCGGSLCLLFSLVFFSRARIRPRCTATPTMVLFFVFSLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MK29</accession>
    <name>A0A2X0MK29_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C021g09223 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C021g09223</name>
        <name evidence="3" type="ORF">BQ5605_C021G09223</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000083">
        <property type="protein sequence ID" value="SGZ19814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MK29"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="2">
        <location>
            <begin position="255"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ19814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="546" mass="59343" checksum="5198A010A32E763F" modified="2018-09-12" version="1">MDAKIAKELKKEVRTQAEIIQFLDEANLRLVRGCYTSYDILDSLNTFYLGTMSAQISALTTELYARKFSSGDCGQLLHHLITVQGILQDLEACGSGMPPAQQSTLMLDSVFDPQHESFTSSLRRPLALPSEIVSEARSYQFKVSLASRINGLSATTSGRAMAPSPVPALVAQGESQKGARHKRRLKKGNRDGQGNRRPTDSTCHACGAKGHWSCDAVCPEKRSKSSAAPALVAMNSHSVYLAGSSSRAPDADFVWIADTGAGHHLVGDRSLLSDFKESPIQVQMADNSLGQATGYGRMSAKTSQGHLLNFKEMYYLPGSKYGLISMSSLRAGGAKLVYGHGGDTQQVWLDGSLVAETVKTKAKQPSYVFDFEIVSPPLPVLVAATRASVGASLMEWHRNFGHMAPSSILQLVKSKAIVGIRLLDKKIEDCKPCIIAKARAGSHKHFSRKPGHVLQRVSIDLGFVNDDDTNGRSIYMVIVDQLSTYKWAFPLGSKSASEVLKVWRGFQAQVERQSGQKIKIRSPQGLARLSSAGREAVRSEDQVCSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKB7</accession>
    <name>A0A2X0MKB7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">BQ5605_C013g07116</name>
        <name evidence="18" type="ORF">BQ5605_C013G07116</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4"/>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY14823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MKB7"/>
    <dbReference type="STRING" id="796604.A0A2X0MKB7"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031502">
        <property type="term" value="C:dolichyl-phosphate-mannose-protein mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23283">
        <property type="entry name" value="beta-trefoil_MIR_PMT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000034">
        <property type="entry name" value="Dolichyl-phosphate-mannose-protein mannosyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF50">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="311"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="691"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="726"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="755"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="785"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="419"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="488"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="561"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="87"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="930"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="962"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="10"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="934"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="962"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="989"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="1007"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1032"/>
            <end position="1044"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="SGY14823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1085" mass="121547" checksum="34F1F52F809D2385" modified="2018-09-12" version="1">MDSLRTRKGAAAAAAAAAATCGTQHSAHQHPPSQPQQHHHQASAAASSTGAPSQALHGNGGSSAYYSAPAAGPSLIPKVDFSATSSKPLSLTKREQRSSSHKGSLKDGKRSLPRNTVWDRMGGGFNLGPGEGRLLLGLFLLGSVVRLYKIGRPSSVVFDEVHFGGFANKYIQSRFFMDVHPPLAKLLIALMAYIGGFQGGSFDFKEIGREYGPEHVPYILMRLLPAVLGLLVIPIAYLTLRGLQTRPTTALLGALFITFENGLITQSRFILLDSPLIFFTALSTLFWVGFSNENEVPRDRAGRVGPFSRRWWIWLTLTGLALGAVLSCKWVGLFTISTIGILTILQLWTLLGDLRVPIPLLVRHFVARALCLIAIPIVFYMAMFKIHFAILSNSGDGDGFMSSEFQHTLRGHGMEDTFAVDVMIGSTVTLRHLRTQGGYLHSHPSNYPGGSKQQQITLYPHRDENNNWLVLNSTADPERPDPQNDSPPRPLQDRDIIVLHHVSTNKKLHSHDIRPPISEVDYQNEVSAYGFEGFDGDANDHFSVEIDQTETDTKHGGRDAKKRVQTLRTRFRLRHLLTGCYLFSHKVKLPEWGFEQQEVTCNKNPSHDNALWYIETNEHAALPSTSPKVNYRLPGFFGKFFELQKVMWLTNAGLTDRHAYDSRPHSWPLLRRGINFWVKNHRQIYLIGNPFVWYLATFSVLAYFGIRGMLILRWQRGYKDFAHSQVVFYDGVCGFLTLGWFLHFVPFFLMSRQLFLHHYFPALYFSILLSASVFDLATSFLKPKFRLQAVVIFALGAMATYWYFSPLTYAGVWTREQCMRAQWRSHWDFSCDDFLSKDALKKQAHVEGDVAVTTGISTTAVVNELLPGRNAFGEDMIKAPVSSIIPNDPLATPAAAVPGPDDPSTTIMPEDRPEAMVLPPAAQQETDLVPPPARAAAGENAAPVGPKDEAGEKLEAVKEMARNAEERFEEEQKARQVRQAEAREDEIEEYRKEAENEPLKIWERIEPKRKRKPKPKPKPVPVKAPAKKVVIDADDDGEEEEAEVDAYVRKIRAQQKYTDDDDDDDDFNIKNVGKPKLDEDLPELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKI2</accession>
    <name>A0A2X0MKI2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C031g11004 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C031g11004</name>
        <name evidence="1" type="ORF">BQ5605_C031G11004</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000068">
        <property type="protein sequence ID" value="SGZ07263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MKI2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ07263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="356" mass="39443" checksum="9AD59CC3CA65EFBA" modified="2018-09-12" version="1">MSTRMIGSLRFSSLFRPRFTPICSKTHTAATSRSAPTAAENPLLCPRFRDASPLQRVEMVKVGRHLQSPKLDVDDLTDRLQGLTCAVQDMTIVALTLAALEKPFARDARSGGDQAAVADDPSVPKLGIREQLFGPDLKEKLFRDLMTMDNLPLLMSTSILDAVKLLWDNPDLKLTKSGPTDFRRHFSLVRECGKSQILSSIAAPQTLATVVAIEFEDFELKYNKEGLRIYTDGLAGLQVMSQKRGRSSFPGVLSIARTPVWHSSLHLLTSYWSSLVDGRLHLLLDHGYSAVVENPSTNSDAPHRPGISVLISLFMTHHPSFEIEAPSEDVKNKVRDKMYSLPKYDFDGLPIISGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKY8</accession>
    <name>A0A2X0MKY8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01525 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01525</name>
        <name evidence="2" type="ORF">BQ5605_C002G01525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY33681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MKY8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY33681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="263" mass="28186" checksum="74373BD3C90F9C0C" modified="2018-09-12" version="1">MSMATGSPSDYASTQRTITFLTLPVTAQLKHYSSYPLPLETSLHASVTEAAQAAHILGIAADDSQHLSGRTTPSGRRLSLANSRPSIPHNREIRIFRASQDANAISLVVEHEAASGVDLGRPANPLPPVGPIDEAGEKNEWILVLRIESQYGDLKLPRFPNKVPSIDCSLSSISEPNPQRIFTQVVIPVPACLRTLLTFELPSPSSIASTSLSASTEGQWGLSMKPDLRNLSSKLSTVTSLPTTSFTASFKSTSSVVLSWDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MM49</accession>
    <name>A0A2X0MM49_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C012g06693 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">BQ5605_C012g06698 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">BQ5605_C025g09956 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">BQ5605_C030g10769 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">BQ5605_C044g12129 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">BQ5605_C068g12842 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">BQ5605_C068g12849 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">BQ5605_C107g13193 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">BQ5605_C123g13317 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="13">BQ5605_C142g13434 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C025g09956</name>
        <name evidence="2" type="synonym">BQ5605_C012g06693</name>
        <name evidence="3" type="synonym">BQ5605_C012g06698</name>
        <name evidence="8" type="synonym">BQ5605_C029g10739</name>
        <name evidence="6" type="synonym">BQ5605_C030g10769</name>
        <name evidence="10" type="synonym">BQ5605_C044g12129</name>
        <name evidence="11" type="synonym">BQ5605_C068g12842</name>
        <name evidence="12" type="synonym">BQ5605_C068g12849</name>
        <name evidence="7" type="synonym">BQ5605_C107g13193</name>
        <name evidence="5" type="synonym">BQ5605_C123g13317</name>
        <name evidence="4" type="synonym">BQ5605_C127g13343</name>
        <name evidence="13" type="synonym">BQ5605_C142g13434</name>
        <name evidence="2" type="ORF">BQ5605_C012G06693</name>
        <name evidence="3" type="ORF">BQ5605_C012G06698</name>
        <name evidence="9" type="ORF">BQ5605_C025G09956</name>
        <name evidence="8" type="ORF">BQ5605_C029G10739</name>
        <name evidence="6" type="ORF">BQ5605_C030G10769</name>
        <name evidence="10" type="ORF">BQ5605_C044G12129</name>
        <name evidence="11" type="ORF">BQ5605_C068G12842</name>
        <name evidence="12" type="ORF">BQ5605_C068G12849</name>
        <name evidence="7" type="ORF">BQ5605_C107G13193</name>
        <name evidence="5" type="ORF">BQ5605_C123G13317</name>
        <name evidence="4" type="ORF">BQ5605_C127G13343</name>
        <name evidence="13" type="ORF">BQ5605_C142G13434</name>
    </gene>
    <organism evidence="9 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY15894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY15908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000025">
        <property type="protein sequence ID" value="SGY27578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000029">
        <property type="protein sequence ID" value="SGY27817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000069">
        <property type="protein sequence ID" value="SGZ08096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000076">
        <property type="protein sequence ID" value="SGZ11192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ16202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000087">
        <property type="protein sequence ID" value="SGZ26792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000114">
        <property type="protein sequence ID" value="SGZ31294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000130">
        <property type="protein sequence ID" value="SGZ35004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000130">
        <property type="protein sequence ID" value="SGZ35035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000141">
        <property type="protein sequence ID" value="SGZ35663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MM49"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY15894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY15908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY27578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY27817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGZ08096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGZ11192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGZ16202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGZ26792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGZ31294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGZ35004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGZ35035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGZ35663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="70" mass="7214" checksum="D56A1EAC56536744" modified="2018-09-12" version="1">MRQSPLMSGEVGCRTEVVRGKLRNRKGARTGIGPAAGELARAPRQLRASKSPPQGGGLAGARPSPLAPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MMC3</accession>
    <name>A0A2X0MMC3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C020g09138 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C020g09138</name>
        <name evidence="3" type="ORF">BQ5605_C020G09138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000082">
        <property type="protein sequence ID" value="SGZ17718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MMC3"/>
    <dbReference type="STRING" id="796604.A0A2X0MMC3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013718">
        <property type="entry name" value="COQ9_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08511">
        <property type="entry name" value="COQ9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COQ9 C-terminal" evidence="2">
        <location>
            <begin position="209"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ17718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="303" mass="32730" checksum="FBD16C3853B86FAB" modified="2018-09-12" version="1">MHAPNVMASAPHYTSTLLRHALPLIPRHGFSLHTLQLASQAVPSPSSSSPLSLSSLNALFPSPPPRSHPNGTVSRRKTLTREQLIREARAQAPSGTASTFRSPLHNFDAIDVDAQAQATIGVGVGPLKALVQAWLEQGRTEMVQHVAVSRGKANQDQLVKLGLRHRIKYNEPVVDQLVEALALLGAPTSTPLSSPSALLPFPSPLPHFEHVARIAHDLAAASGDQSQGLEWYSVRASLGTLYGLSELHQLSPQLQGHDPSQRTLETYEFLDRMWDKSDGLAGLGAFATWVRRSWTGMGTSLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNZ3</accession>
    <name>A0A2X0MNZ3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C022g09478 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C022g09478</name>
        <name evidence="3" type="ORF">BQ5605_C022G09478</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MNZ3"/>
    <dbReference type="STRING" id="796604.A0A2X0MNZ3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057511">
        <property type="entry name" value="WH_GDS1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25318">
        <property type="entry name" value="WHD_GDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDS1 winged helix" evidence="2">
        <location>
            <begin position="203"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="683"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="823"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1012"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="472"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="707"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="841"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="871"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ22354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1084" mass="114524" checksum="5278F93F72358DC2" modified="2018-09-12" version="1">MLTRRSGSGSGGQPLTKTASPSPGANHGGDIGRRNEAPAAGAAVVHHLTRRRTNSVIRPPRRLDSPSPDRTSSMSTGASAAAGAQSRSSAVTRAGAGVGAAGAAATTSSSTLSTTHRHGTRLASASATFASASGSPSHAVPSHTTTTSTPSTSNSASHAGPPRRAPTFPHNDSYVPNAATGHPRDFIPPELDFPPPAMAAKVRQQDADDKLLMAICDVLLSHDNRALCPKEIAEVMFARDWLKSAGTTPFAHISTCIRSHTRRAQIANPPYQPLLVPFELVGALSPHEVTAVGLVAEERPAVKRGTLWYLNEALFGSGLGVEDPFVRCRRAAGMSTAGPASLRARGLVPLSTLQTDDDDGDDGGMGRGKRKRRASSAMLAALTTDIDSTSVAMNARPAMLLTGHRGAAALQSSHHRRNPPTAPLMSSAPAKSGLPKLRLRLTCLEEVENDSDGFTSDAARRRRASKKKSRRGTSAGASEASGGRSGSVESERIDANLAGHSSSEDDDVEDLMIARDMSRSPGKYSSASSSALLAQSLLAASTSSPMPPISDGPRQDAVSPDSLQLPYASPAGSASFRPHRRHHLSMSAPSLVSPFLSARSPEMVMEMDDNMGVPQRVLPDADRLDSADEDDFHEAMLRGDDFDFEWSSESYTSNITLPPFSSKSRSREMSLSLPEGAFDLKDEIDDAASTPATTPRSPAGSEEPELGPASAAPAGTASIDGLGKMGMEETLCGAYAGKTDDYPGSQTIEIKVEDTENGESERVRSTDSLTSLVDEAMSAEPETPVVTARTVDESALAVPLPSPLALDLPPMLALTSSVEYDFVGHEEEQHAPFGANSAYEDNADDEEEDEDDDLVTVKLEDGGSILADTGSSSASSRSSSTFPYFDSLSRRMHALRNSPSSPGSSENGDLFCDLTPTVVSKSMLATGLPVPQQAPSPPETTDWGLQLDPDEFELDISHSADFLGPEAVGLEELDLAWGGEDEEQAEFETDEQFKLRCEQRLKTRMMEKVASTPTFLTGCRPSTPRSRSHISKTSTPTPAALRAALHADDDEDDAGPPPPRTSAKREPLRPCDIIADSEGSDEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPW6</accession>
    <name>A0A2X0MPW6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C023g09621 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C023g09621</name>
        <name evidence="2" type="ORF">BQ5605_C023G09621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ23687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MPW6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ23687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="398" mass="41472" checksum="0281003D4F6EB79B" modified="2018-09-12" version="1">MAPPFISDGTPGNSHVSLSFVPQYSTVEVVSRTIYGASGRMHGRFTGVSLSGANKCAATQFNSNEGRDYDVVAYGCTFNRNHTGAKMIFNVLPCGNTEDALSLAQKIRGVSKKEDFKFKKANPKSSPSRKSSGKSGAHRNTPHRPQSDLSSSGQPGRHHVGGYRGRRHSGHGRRRGGHGGHGGHGHEGGNHHGGGHGHKGGNHHGGGHGHKGGNHHGGGHPQHHHVRSLCTGNSLACQRRRQYLAKRDSRSQMLVSPQGPSPQGPSPQGPVSPSGTPKQSASGASGGAGSAAGDHGPGPQSTAKKTQDGAVSQQASKDPNPASEADKSNSEIADHLRKNLMSGKAQTVCIVGQDHLSDMQTAGLTGKETVGAGGVPGLMYDLFDASNDAFWLTMTRVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQ35</accession>
    <name>A0A2X0MQ35_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BQ5605_C024g09892</name>
        <name evidence="16" type="ORF">BQ5605_C024G09892</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ26346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQ35"/>
    <dbReference type="STRING" id="796604.A0A2X0MQ35"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000011">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000385">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CRIB" evidence="15">
        <location>
            <begin position="333"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="643"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="255"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="416"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="569"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="276"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="416"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="497"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="672"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SGZ26346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="918" mass="96869" checksum="F21CF45E1AB81002" modified="2018-09-12" version="1">MSASGSTSYSAGSYIPKRQAPAPPGPTQYDSPSTSSQSKGNGYGLGHAEPNRTSWGSGAARSSYVPSSRPPYLASSNGAGAAPGSYQPSRPPPPPPTSQARTPPMQSSATFGNMSPSSSKPSTPTRQPSLGLSNHSSGGLGSAWEVVDGAPNYGPKRPGPPPASGSLRELSDTLPSTSSGGYRGSTSANSSNTSLNMHAQPTLSINTHSQHAYAARQYHHTPSASLGGPAGYSLLTDPATAVAAGLAADVSAERWTGPSNSANSLSGRAGQPLPPRPDRIPDNEWDRGASDSPTSARGDGQMGMLAKGEKSKKGGFGSFLADVFSNPSKKVEISTPYDPVHLTHVGYNPDIGEFTGLPKEWQQLLQDSGVTKEEQAAHPQAVAEIVAFYQDVTKVADAQAGAEQDDVWNKMGHATLSSTTAPSMSSRQGQFEQPRAAPPPPPGFRKAPGPPPPPASNAFNGLGRPAPPPPKDRAVARDPRPPTSPDRYDYHVPIPDWSQQQLSGVTTAGTVSIPSKTLDRSPSQRTATSPGPLPPKSFQPSQVTAAVASRADGLIRQAAAVAAASAAASSSSGVNSSTPHRAAPQIPDAAPTGPSPTSATAIPAGVEVAKPTPRRREQRKKDAGDLVERLKAICTDADPTKLYRNLVKIGQGASGGVYTAYQVGTNLSVAIKQMNLEKQPKQDLIINEILVMKESAHRNIVNYIDSFLLKGDLWVVMEYMEGGSLTDVVTCNIMSEGQIAAVSREVLDGLQHLHEHGVIHRDIKSDNVLLSLQGDIKLTDFGFCAQIQGEHAKRTTMVGTPYWMAPEVVTRKEYGPKVDIWSLGIMAIEMVDGEPPYLNEPQLRALYLIATNGSPTINNPEQLSDVFRDFLKQALEVDSEKRPTAAQLLLHPFFKKAQPLKTLAPLIAAARQAARSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQF0</accession>
    <name>A0A2X0MQF0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C016g08219 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C016g08219</name>
        <name evidence="8" type="ORF">BQ5605_C016G08219</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY21288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQF0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="231"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="76"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY21288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="450" mass="47777" checksum="883365A5C1D2A5B5" modified="2018-09-12" version="1">MSTVANTSSQGSRRSDSISSGSVSPSLSSSPSGMLQQPVVAQAVPPPSVAMDQEHGVGHVRMRSVNGDSPLLGGDKEFYDIPSANGNGNPSPNANINAHAASPSASTSANRPSPSPRSVPAWLIVGGWICLSTAVILYNREIMMGSKQFKYPITLTSIHLLYQTIATRLLHKYTNLIAGVRTPDYTAVSMDELETGSKSETSAAYATTSAPDARQLQTAKDSAVFVPWGEYKRLIIPPAVMFSLSLVLSNWAYLYLTTAFIHMLKAVSPVAILLAAFAFGTKTFSVKLLLIVIVISFGVGIASYGETSFNMTGFMIQMTAIAIEATRVTLIQILLAGKDMSPLKSLYLFAPICLAINVSLILPVEGFTALAAIPKLGFWIIFSNASLTMALNLSAIYLIGISSMVLSLSKVVKDVIMVGGSALLLGDNLTSLQAVGYTIATVGMLYYKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQN0</accession>
    <name>A0A2X0MQN0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C043g12106 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C043g12106</name>
        <name evidence="2" type="ORF">BQ5605_C043G12106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000117">
        <property type="protein sequence ID" value="SGZ32184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQN0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ32184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="371" mass="40682" checksum="5E5F6B808081723A" modified="2018-09-12" version="1">MSPVQTEAQASPSFSLLLFTPCPSHLIPSPPRARDIRSGRCGSSATNTGYRNGCRMQHSYEFDGRIESIDFVRLRIRVIGTLNASGSVNCGSPCRGYSPLKLATPVKRSTVLAGRTVEEARARKSPSQAFARSNVQERSSRTPESPAGGAFFFFDILRTQNPENRRGALQKIDLLGRNTRFAPEAHVQILTFSPYGMALGPFAFASKRASRCSRLNKSLAIFGNHFSSVAHDEMIPCLFLDEDQDYYLNDDEFDRLSPLTNMTVKLPSSSPSMSLPPTPQRYPHFGSLDGAVTAATPLGIGSLICFGLKCGMHSLSCDQTVYGEETLSIGIGTDNKPQQPRHARRLVGSTLKCRRTGASPHQENMLFHTPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQR1</accession>
    <name>A0A2X0MQR1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C024g09923 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C024g09923</name>
        <name evidence="2" type="ORF">BQ5605_C024G09923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ26480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQR1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ26480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="549" mass="61149" checksum="3FC999F685E656F8" modified="2018-09-12" version="1">MARPSVAGGALLDPAFDDDEHPLRHEHQLQGDAYGEHDPDQSFDELDVDGFGGHFSHHDALGDQLGPGFGSMLDTLGDGDDGLLVERFDDDDRDRSYVEDDDDELERISTTTPGDPAASPSRRSRSMNHHRTPSRSHANGIVQDDGHLSLAFELASAQSPARAPHDRDLMRQLGFDEEDQVGDDHEPNEDAQSHDRSFDDQDEHHGALQAEVEDVLPRSTSNSPEHPSSPSRQSTLGRRSIISRSNNHMSRASIASFATMLDAQPDPVDLEAVLAEASEQVNESNLIVTSFLNHLKRHTTNEVTPEHEDDKEDFWIDRQPVIEVLANTLLRSLHERTKTCQSQWRELAEIERALAKNDVGWQATLGRLDDILWTSDEEEEEEDEGQEEGDCSEERKQDGALTSIPPTIPGSEPNDPTPLPPPHRAKHRPPQISPTTTAVEELTTLRNVTASLTDSLSSVHEMTQVNHAAAGDTSRKLRALRAQATTLRDELNAWERAEEFVAHREEEKTNGGSLSWRENIASLAREEMREAETLLNEAWDKATSMLCVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQV9</accession>
    <name>A0A2X0MQV9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C040g11837 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">BQ5605_C064g12784 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C040g11837</name>
        <name evidence="2" type="synonym">BQ5605_C064g12784</name>
        <name evidence="1" type="ORF">BQ5605_C040G11837</name>
        <name evidence="2" type="ORF">BQ5605_C064G12784</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000118">
        <property type="protein sequence ID" value="SGZ32261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000132">
        <property type="protein sequence ID" value="SGZ35140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQV9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ32261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ35140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="55" mass="6416" checksum="054637C7084FE755" modified="2018-09-12" version="1">MRSDVNVVVEVRYIDQRLGEQDRKAGERSGQAQIKARRHFYPLEWTVHVHGVAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQX5</accession>
    <name>A0A2X0MQX5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C040g11920 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C040g11920</name>
        <name evidence="3" type="ORF">BQ5605_C040G11920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000118">
        <property type="protein sequence ID" value="SGZ32829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQX5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="311"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="884"/>
            <end position="910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ32829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1128" mass="127062" checksum="7E73972D222AB260" modified="2018-09-12" version="1">MFGLPKLKASLRDQEGAGRTIEIFTGLVLEMISSGRWGMQKWGTRMEGVGRRRIILEERLCRFDSRVVDEVYRRLEGTAPLGDVYDAALRAVAAAGHARYRSTRADMRRLRAENQSVMEALEARGEHMNEAERDAYALAKSQLDQLAVKEAQWLRIRAHVPSVDSREGQSASIRTRLNRRSRQTSIVSLEDVDGTETVDMQEALGIASRHAQSLFMPDPARGDPTNARRSLLDPIRASKCYDDDRSDPTFGRRLPLQARVALDEPFNLSEVEAALKKTDSGRSPGPSGIPYELFKALPTYFAPKLLDLFNSIWEGGKMTASLAEGLVRLLPKNKPGANLKSLGAYRPITLRETTYKVLSKVLVARLNGVLGELLPPAQHGFMPSRRSADAGSHLTLLLEKLKSLGTEVFPEGALLSLDQQSAYDRVDHAWIFDVFEAFGFGERFISLLRALYDPETLGVRYLVNGFPTDLVRLLCGLGQGDPLSCPVWNITFQPFLDALVRRGIALDLQKSPAALSKLETLSQTWYEATNGKTNTDKTLVLPLGPNWLRDETAQALPTVQEGESFKWCGYAFFRHGDSKLFWTHVLDRIKAKARAARDRTLSPSGRVFYANAHITSTVLHVLSFDIPPQWFIQAAETALTDFVWGGPRRNTVARDFVFQAREDGGLGLISIGDIVHSVALRFWDAVAGSDEAIWAPLARESWRSLVAATRDFSPWGFFSSTARVEKLYRDSARWGAVVAAARVTLPTIKSELLTLPELLSLPPRLPSLYAEGAKHAYDDADAVAKFAQIADLYWRDEGKGWALVGHRRGFWQHSKEPALRHEHVWARVGQKLKAKALLPKTAVRPARIPLKEAPRPRCFNFFGLTRPFTIRKLRRLVNTVRFPGKDGQDRALPGGQPQEPRVKRFPEGTSQSGRQRFWSWLHDRFASAAEQDTHWRLMYDVTPTRKKQHVQGHASSPSCLFCGNDAAVIETVSHYFFGCAYSASYWSGVLRILFDKLGIEDTDVDPSTFTQEQLTMGLPLLRGRGRTTSKWMWIRLACAIGFQRLHLLRWHVHQRFEKDRVVAPPSIPSALRAFNRDYLSRAGFVPGARDWEKARSFYWIVFCRLPTAQQPALETQPRRDIRRCRGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MR56</accession>
    <name>A0A2X0MR56_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C019g08981 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C019g08981</name>
        <name evidence="7" type="ORF">BQ5605_C019G08981</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY23777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MR56"/>
    <dbReference type="STRING" id="796604.A0A2X0MR56"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF32">
        <property type="entry name" value="ARGININE METABOLISM REGULATION PROTEIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="182"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="820"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="964"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1016"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="823"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1017"/>
            <end position="1028"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY23777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1053" mass="116159" checksum="C5F06473D92D91EE" modified="2018-09-12" version="1">MHAFMPTGSVSPPLQPLPNTTAPYTASVKAASGAVLGGQQQQHPHQEQHQAQVPTPAVAEARPIQPHRLNSSKSTYASTSTLYEAAVSEGFEQIAAKSCLRLARARPLWLIEFEGDPARVLLDSAARFLFSWQPKAASRAEVAQCRDRKVKCDKIYPNCGRCLSRKEACGYKVGMIISTRPITSNADESAEDKERDSDTDFRSSRPRPADQDFDHHLRHEVAAGSYELAQETPGRPPPSEPGAELPSRPIARLPQRPLSNHVIYAVKSNRYYDSAPPQGAAYEDTAFYPPMAAQSTSADYADTMQSTHTYQERLELPQDTLLAWHRLIGRDDIGERSVDWQLARPTMATSLQRHLLEASMHSCCSHLPAFRPFASRVQYFKENIDRLDLSSQIIVSVLVSLGARASPHSALLGVDGVDIESGQTPVSLLLTAGERRETAWRSIASRAVELCSRPEIVQAPSRQNVESLLAISAMLKLCETRPARARYFLRNVVGMFEDLQTSDMMSEAEVRDLKAAVGPTVYESDARVAAYLSMPVLIGNRDVGSYFDGANIIIPDLKSASLMNDLLAILSPARGPLDRIKFDDALEIAAYYVCAIQRSYAAICSSRSAFNSLLAEIPKLWTYIDSAHSAVQHLHRTLVSLDLRDAYSDHAIEYDLLISVRLDTRLIDVINLTHSFLCRQLDRSWPEQDHLALQQLTALSERRVRKALKLLSFYAKVFSDSRDKHLVYHLFLQLDILPAWPDMVSQRVGEPTAFGPLNEESALTEQELDWFVKALEMACFYTPSVNAQLEIIKRGREQRRSAPTSLYNFDLAPAAPAHYHEVSSSSGAGSSPSDIGLNGEGRYDHSNTNPRLAEMLPGAHANRIVTASSILSTVPALAADPTYTIPCRARGVPDRPVYTYGPYEPPANLSEHSSRSPVDAVVDKTTADQQPWVMDSDLECMLSGATRSSEASITELYANGTRGDGTQLHALANSHSHSHSHSHSHSDAELVPNKPASDSTIFARRRSQDWYSAPVRYSQNSTSNSTASFEPPHAGPGGVYQENGRWAGAISNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MRI4</accession>
    <name>A0A2X0MRI4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dynamin GTPase</fullName>
            <ecNumber evidence="2">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C027g10385</name>
        <name evidence="14" type="ORF">BQ5605_C027G10385</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="2"/>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MRI4"/>
    <dbReference type="STRING" id="796604.A0A2X0MRI4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
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    </dbReference>
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        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1240:FF:000002">
        <property type="entry name" value="Dynamin-1-like protein isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF235">
        <property type="entry name" value="DYNAMIN-RELATED PROTEIN DNM1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="13">
        <location>
            <begin position="23"/>
            <end position="333"/>
        </location>
    </feature>
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        <location>
            <begin position="773"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="77"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="540"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="564"/>
            <end position="580"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
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            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="SGZ28603.1"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="860" mass="93084" checksum="776D2627134BF32A" modified="2018-09-12" version="1">MDSDLISVVNRLQATFSAVGGDAVDLPQIVVVGSQSSGKSSVLETIVGKDFLPRGQGIVTRRPLVLHLVHTPPPLPIAGHEGVASSSQSSVGDAAPNHNNYASSSSSSSATASASMPVEYGEFLHIDRRYYDFNEIRKEIENETLRVAGGNKGISRLPIHLKIYSPHVLNLTLVDLPGLTKIPVGDQPTDIERQIRNLVLDFVSKPNCVILAISPANVDLANSEALKLARTVDPQGRRTIGVLTKLDIMDAGTNALDILTGRVYPLKLGFVGVVGRSQADIIANKPMEDHAASEREFFRNHPGYRNIAHRCGTKFLAKTLNQVLMNHIRDKLPDMKARLNTLMGQTQQELNAFGDSTFLGEQHRGSLILQLMTQFVRDFVASIDGTSLEISTKELCGGARIYYIFNDVFGHALESINPTHNLTVQDIRTAIRNSTGPRPSLFVPEVAFDLLVKPQIKLLEPPSLRCVELVYEELMKICHNCTSTELQRYPRLHAQLIEVVSELLRERLGPTSEYVQSLISIQAAYINTNHPAFVAGSATAAQESSREVARRRQAAIADKKSSSSEEEELDGSGPEEEDDFNQSGFVAHSGRNETLSKTRSASSTIHDRARNGPDFAQFVGGPSVASGAGQRRTGSGSTTALAVPKANGASSNLTASGVAGPAGFSGSHYGSSAPSHASAKESFLNYFFGGTELTGSEHGGNGMQHALGSRGAASSIHASMLHERGENPLSGRRGFEGNAAAFDMKSLEKHLEASPAASADPHNGLTEREEMETTLIRALISSYFSIVRQTIQDLVPKAIMHLLVNFSRESVQNRLVASLYKESLFADLLHEDEALTAERTRIKGLLQAYKEAFSTLSEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MRS2</accession>
    <name>A0A2X0MRS2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00782 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00782</name>
        <name evidence="2" type="ORF">BQ5605_C001G00782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY49458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MRS2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY49458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="128" mass="13897" checksum="70AAA90422D5D4B9" modified="2018-09-12" version="1">MAGNAGPSDTDVLQYVATQAVATGSLGPFVLGMLLDVYLGGFALSLFLRYVRSSAWRADGWRLRLLLLSAMALSLIDIGSNYWSTWHYMTSQERAADVLYSQTIVDAFSLVPVGLVGSSRNDSRESPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MSU3</accession>
    <name>A0A2X0MSU3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g03998 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g03998</name>
        <name evidence="1" type="ORF">BQ5605_C006G03998</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY55285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MSU3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY55285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="242" mass="26496" checksum="D6A9F46D46FB4A17" modified="2018-09-12" version="1">MENYQAKIPFNTSSSNVNPRVASSPPRKNCASPSFSLLLFTPYLPHLIPSPPRACDIRSGRRGSSATNTGYRNACRTQHSYEFEDSLQHDLFECQLSSCFFNIRLWLGESRLTIPWQILNGSVRCGDHRVGRGSEAMRSRYSQGIACTNCSGCVKCGSPNRGRSSTARFGGVIVVVAGDPKQCVPVIPKSSSTQIVNFVDAPGGTGKTFLEETVLARIRSEGTVRRAPYYGPQALEIEIART</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MSW5</accession>
    <name>A0A2X0MSW5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C044g12163 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C044g12163</name>
        <name evidence="1" type="ORF">BQ5605_C044G12163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000114">
        <property type="protein sequence ID" value="SGZ31385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MSW5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ31385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="187" mass="20439" checksum="E95BA01D39B23CB7" modified="2018-09-12" version="1">MNNRREADSYSLNFVAAISRYVNTCRGTSALPHALKAFKHTDQSCSTATGPALSVYLFSFYGLHAKMAQSQELEADSIYDWIAEQVDNTSSAGYRSELTPKINTLAAALPQLYRSVMGQIAFACNRRNNAMQHRNSLMTLACGANDQLTTFLYDCGLMTDISLGDSPGSCELDEGEGGLEQVLPCDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MT55</accession>
    <name>A0A2X0MT55_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA polymerase</fullName>
            <ecNumber evidence="12">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">BQ5605_C042g12012</name>
        <name evidence="18" type="ORF">BQ5605_C042G12012</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="12"/>
    <dbReference type="EMBL" id="FQNC01000116">
        <property type="protein sequence ID" value="SGZ31822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MT55"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05776">
        <property type="entry name" value="DNA_polB_alpha_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05532">
        <property type="entry name" value="POLBc_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3200.20">
        <property type="entry name" value="DNA Polymerase alpha, zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024647">
        <property type="entry name" value="DNA_pol_a_cat_su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038256">
        <property type="entry name" value="Pol_alpha_znc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045846">
        <property type="entry name" value="POLBc_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015088">
        <property type="entry name" value="Znf_DNA-dir_DNA_pol_B_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861:SF1">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12254">
        <property type="entry name" value="DNA_pol_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08996">
        <property type="entry name" value="zf-DNA_Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase alpha catalytic subunit N-terminal" evidence="17">
        <location>
            <begin position="11"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="15">
        <location>
            <begin position="588"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="14">
        <location>
            <begin position="902"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger DNA-directed DNA polymerase family B alpha" evidence="16">
        <location>
            <begin position="1393"/>
            <end position="1603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="56"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="149"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1431"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1438"/>
            <end position="1448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="SGZ31822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1611" mass="178626" checksum="28FDBE682B4FD31D" modified="2018-09-12" version="1">MASREAKRKQLEALKAARAGGGRVWENKEQAPVFDVVDEESYRSVVKGRLAEDDFIEEDGGVTGYADNGEDHWDRSDEEGDSDDEEREAAQKQKKKEREAKKQQSAAALKRKAKQPILAPGANPYIKPAKEEAEVDDFMASLMGDLDGQEAVVSKPKPKPQPAASTSKLGRFAKTTSLSSLKRRAGADDPMGAERGIARTTSSSDVHASDPLSSEAYYGNGRETGPSSDGDDAAAVLHVVGKKARFSEVEHDLGGAVQSLAFAESKKGNEIEQDVDAANTTIVKVKAEEDAEEDAEEDDDDFIVKPSAPVVKPKGAPVRRQLVNTSATKAAAVKSERIELNIPGLPAAPPLAVDAKAKPRGTDWRTATSHLAAVEMPANSMDDVNMSDASLGDDADNPLPVPESLRKVVKTTDVVLEQVQSKEEDGSLRFYWFDYVEPSPGQLCLVGKVKVTSAQTDNKGKGASKADRYASACLTVTGLRRKLFVLPRAKALDMDGNEIDDEDGPEFDDVVADFDDTAESKWNVKNLEVVGETWVKKKYSFGIKGVPREETDWVEFASDFPDANLSSPSIAKFAVDIPLNASGERFSHVFGSTASAFETFVVANRIMGPCWLNVKAPVYSDPKKAGATWTKLEVSADHSTIHPFSDQDPTAPTAAPPLTIMSLSTRTVVHITDNKREVVCAGARVWTDANIDDPTPLEKQPSQMTSMVRNLFTPFPVGFEAAARATAKTSRDRIIPFKDEKALLTQLVSIIFRHDPDIIVGHDFVAGDLDVLLNRLKELEVETWSKVGRFRRPKWPKLTAGRNLKLLDGRLTLDLSSDNSKAVIDSTTWTLTEMCKTHLDIDREDIDPEDTAKYFDNVHSTAAQLLHFVQHCGADCYLQMAVAFKVQVLPLTRQLTVFAGNSWNKTLAGNRAERNEYVLLHKFTALGYICPDKVASWEKKAQIAKEDAKSRKGKKGKANEEGEAVVKVEMKKAKFTGGLVFEPIKGLWDRYVLVMDFNSLYPSIIQEFDIDFSTIDWTADEAQDVETMPERRPCEGEPQGILPDLIAGFVKRRRQVKNNMKDKNVSPSKMQQYDITQKALKLTANSMYGCLGYEGSRFYAKPLAALTTFKGREILTNTKADAESLGLNVIYGDTDSVMINTNQTDIQAAFKIGNDFTKLINDKYKKLEIDRDAVFQRLLLLNKKKYAARKVEDDGTIKTEVKGLDMKRREFCALSKGASQFVLDCILSGESTEVVIEQIHEYLSTLGERIRAGVVPVDEYIIFKRLGKNPQDYPDAKSLPHVQVALRMQAKGQSAKSGDVVPYIFCLPADGVSAKSAKAVNAHHPDDVRRQGSILKIDFEVYLGVQVLPPIERLCEHIDGTEKARLAECLGLDVTRYRSTVDAPERDFKTLQSQVSDAQRFRDVEPLRIRCRVCETESIFDGLIKNSVSDPRPSIFTKGHEPRTDQRTRSPQTNMVSKSGFFCTNTDCLEPLSTASIAFQIDNQIRGAIAKFYEGVMVCDEPTCGYKTRMMSVYGKRCLNPGLTCRGTVHFEYNDLQLYNQILFFDTLFDLERARTKSAGTTTQDQVNEIMDAQKPTFETLRSVITKHLEKNGRRWVNMQSLFGFMSVVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MTT9</accession>
    <name>A0A2X0MTT9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C040g11864 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C040g11864</name>
        <name evidence="1" type="ORF">BQ5605_C040G11864</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000118">
        <property type="protein sequence ID" value="SGZ32369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MTT9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ32369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="101" mass="11044" checksum="3A5161FE63A57CC4" modified="2018-09-12" version="1">MLADPMDVRVNRAIDEWDALYRLDEACTADLAPIASLSFTTWSVFTLAGAHSAHLISISHQAKPISLNRNETIIIVAHICLEAEFPEGLRGESRAGREVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MU32</accession>
    <name>A0A2X0MU32_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C074g12901 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C074g12901</name>
        <name evidence="1" type="ORF">BQ5605_C074G12901</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000129">
        <property type="protein sequence ID" value="SGZ34899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MU32"/>
    <dbReference type="STRING" id="796604.A0A2X0MU32"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ34899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="57" mass="6334" checksum="519ACF61CDD59EE3" modified="2018-09-12" version="1">MMSTTKIPNVSFVAAANVQSINEDRKRASLFSNLRSHNDDVFLLSETGRPSPERVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MW59</accession>
    <name>A0A2X0MW59_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Splicing factor 3B subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C003g02449</name>
        <name evidence="13" type="ORF">BQ5605_C003G02449</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B4 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY40947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MW59"/>
    <dbReference type="STRING" id="796604.A0A2X0MW59"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048026">
        <property type="term" value="P:positive regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12334">
        <property type="entry name" value="RRM1_SF3B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12335">
        <property type="entry name" value="RRM2_SF3B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000059">
        <property type="entry name" value="splicing factor 3B subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000121">
        <property type="entry name" value="Splicing factor 3b subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034158">
        <property type="entry name" value="SF3B4_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034159">
        <property type="entry name" value="SF3B4_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052084">
        <property type="entry name" value="SF3B4_spliceosome_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030:SF3">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="13"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="100"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="256"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="329"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGY40947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="366" mass="38647" checksum="9D10D6389341C0D2" modified="2018-09-12" version="1">MSGKPQDDRNQEATVYMGNLDERATDALVWELMLQAGPVVNVHLPKDRISMTHQGYGFCEFLTEQDADYACKIMNQIKLYGKPIRVNKASSDRKQIDIGANLFIGNLDPNVDERMLYDTFMAFGMLVKPASIARDPTTGASKGYGFISYDSFEASDAAIESMNNQFLMNKPITVAYAFKKDSKGERHGTPAERLLAAQARKNNALPSAGGPGGPMGMMMHPPPPPGMFGGPPGGPAGLTGANAMAMFPAPPPPFGGMPGMPPPPPGMYPQMGGMGAPPPPPPPGFAPSGANAYGQPPGQGYARFVPPPPPPPNGMTGGPPPQTGQAGMFPPPPPPPAFGGQYPPPQQYQQQGYAQQPPPPPPVGFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MZS4</accession>
    <name>A0A2X0MZS4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g03950 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g03950</name>
        <name evidence="2" type="ORF">BQ5605_C006G03950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY55021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MZS4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY55021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="194" mass="21664" checksum="70638FF87BB5E9FB" modified="2018-09-12" version="1">MAGSASEKDKERSGSGLGSSAQASGGLKLGPSLVRAKKYIDADGMYAQKDKGNMGLRDYTCKRGQIEKIYYNWVCSVVRDALVVAGIRTPTPVQLYGPLAEINQEWSPNHDLPEKYDLKDAFRLISAKTSTNTVFWGNLSPLKQREIVKYARGTRYVSTRAEDGSKDSWRRERRAKCACTREARGARLISTTRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N0T0</accession>
    <name>A0A2X0N0T0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA replication licensing factor MCM2</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Minichromosome maintenance protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">BQ5605_C006g04300</name>
        <name evidence="15" type="ORF">BQ5605_C006G04300</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY57720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N0T0"/>
    <dbReference type="STRING" id="796604.A0A2X0N0T0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17753">
        <property type="entry name" value="MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000138">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008045">
        <property type="entry name" value="MCM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059098">
        <property type="entry name" value="WHD_MCM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF44">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12619">
        <property type="entry name" value="MCM2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23669">
        <property type="entry name" value="WHD_MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01658">
        <property type="entry name" value="MCMPROTEIN2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="14">
        <location>
            <begin position="496"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="63"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00078186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SGY57720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="922" mass="103544" checksum="1558E3462CA86EC8" modified="2018-09-12" version="1">MASEASYTRSAPSSSAQKRGRSPSPIRQSSPTGPIEARAGSPPPSSAPPSSLPASSPPPGFSDCDDDVEEDGIPLDMTDGEEGDGEDLFGEETGNDYIENNRLDRYDAGDLNDDEDFSDDPDARRAAEAQMANRDRRFARQQGGQRRRQRMPAFLASDEEDSEDENRLLGQRRVRRNYDEEAFEDDAVEEEMPIEQLADIQADSIAQWIEDPRVRRTIMREFKSFLMTYTDPQGVSIYGQRIRQLGELNLESLEISFAHLADSRAILSYFLANSPSAMLPIFDEVTLDVILLFYVDYSRIHAEVHVRITNLPTSFTLRDLRQVHLDALVRVAGVVTRRSGVFPQLKYVKFDCGRCGEVLGPFYQEVTTEIRISFCSSCGAKGPFNVNSEQTVYRNYQKMTLQESPGFVPAGRLPRHREVILLWDLIDSAKPGEEIEVTGIYRNNFDTSLNVKNGFPVFSTILEANHINKKEDQFASFRLTEEDETAIRALSRDERVGKRIIKSIAPSIYGHEDIKTAIALSLFGGVPKDINRKHRIRGDINVLMLGDPGTAKSQFLKYVEKTANRAVFATGQGASAVGLTASVRKDPVTREWTLEGGALVLADKGVCMIDEFDKMNDADRTSIHEAMEQQSISISKAGIVTTLQARCAIVAAANPIRGRYNPTLPFSQNVELTEPILSRFDILCVVKDAADPVIDEMLAKFVVGSHLRSHPEFDPAVDEVQIATALDLDLIPQDLLRKYIQYARDRIKPQLHMMDQDKISKLYSELRRESLSTGSYPITVRHLESMIRMAEASAKMHLREYVRSDDIDLAIQVMVGSFVSAQKSSIKRQLERGFRKYLRVATDHEEVLAFLLGQLIKNRVRYLTVRNGQAPASVVIKVADFETRAKELEIYDVEAFTKSALFRNNGYTRRDGDITKSFSDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N133</accession>
    <name>A0A2X0N133_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C009g05796 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C009g05796</name>
        <name evidence="2" type="ORF">BQ5605_C009G05796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY86034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N133"/>
    <dbReference type="STRING" id="796604.A0A2X0N133"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY86034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="781" mass="85194" checksum="6B50CA62D017C958" modified="2018-09-12" version="1">MDEDASMSASVASTSASPAACASTAATGTESDSSTAPTPQAESQTPASLAISKKAPLVGKRRKLPSCDSCRLRRVLCVPVPPPGSCSRCLDKGIMQKPTGRTGRRIEQARATFGAMETSSLHSAPVADSHAWRTTQTSSTPLSQPSIPSSSRKVLLLPSVSTKDLDSRLAQTQLSGELVAHLLGLWQELPQSWLSVIPQARLMSAFEESGRRLSALPPQAEVLAYTIMALTSRLSSHPYILGDGPPAPAFEAFTSQSLKERPDLQAFGARRDAVCEKMQVKAVQLAWERGTLVEASEETMASCHLLDILESRTDTKKGMPYVSAFVTHLRTLLDERDTVGGGVTGLMKHPGWSALMMRESLSALRMGRRSHFVDADNDALLLSPTPLSIEVMFRHIQNGVGRDPMTTFYGFTNSYMSHVAKMARECSEHVAGSWVRNRPLDEMFVANYLSQLDLLDHLQHSILGLIPLSLTPEATRARAYSHDAETKSRYIMTLCSHTLRFAWAGLVLPLSIELRRRLSLMDVTAMTAEKRRTRDRLQVLKGHAQRALMKAARGVAACVDTPASLAYLTHIQHERIDIWADVLLDLAHEDGISREDRISDLQTVSSRDVFRCSLCAGCSYVVCPYQILAGLKMIGWSWPDNAELITSLEERLQTMRMEDSPPARTEVSTPNNTQQGIEAQTPAVLAQEDLGLFSQYLAMPLPSTLNTAPNSLAFSSDAMSHAFSSNEMNASSTHLSTLPTNVGLGGSAAHLDPAQWSTFGTEFTQMLDEGSRLSALDSSWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N1A8</accession>
    <name>A0A2X0N1A8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C007g04481 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C007g04481</name>
        <name evidence="2" type="ORF">BQ5605_C007G04481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY60756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N1A8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY60756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="89" mass="9258" checksum="964AAC60529EAAA7" modified="2018-09-12" version="1">MSTGSEGSLKFADEEKGVTGHTNATSPKVQIVAADDGVKRDGGILGKSYTSRIERVLPPNDSAFLPDPRATAAICGLGSQFGYFCHADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N1V7</accession>
    <name>A0A2X0N1V7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C007g04711 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C007g04711</name>
        <name evidence="3" type="ORF">BQ5605_C007G04711</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY62591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N1V7"/>
    <dbReference type="STRING" id="796604.A0A2X0N1V7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="792"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="686"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1017"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1116"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="589"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="696"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1018"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1042"/>
            <end position="1062"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY62591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1165" mass="123121" checksum="C6E601F4CE9A828B" modified="2018-09-12" version="1">MPPPSASTTTSHPSSHSTGVSIRLAEPYVLLVGGPELERARARRRRALRQTPIPAQASPSPSRTPSRAASPSHELGAVPGPGPSSTRGRTGGPRNGDPDFIAPNARGRSSTRTRSPSVAREASLSRALAQARVASTSRPPLRVAVNGQEGEAAAAEHDDEPAPAMLRGLLVLHLAKATRIREISVRLRGLARTDWPEGIGPRRMDIMEESILTNITSTFFSANETSMERRAASIGPGTGDYGSDTRFFEAGHDRSSRRAASVRPSRDLSQGRPYGTRDGSTGSNHADSAAMAGLGNLEEETTVGIPVSTLSHIASSEELESRDRHDIPPILPGEQAPAYELVPSLPNSPALRPTRSLGRDSPTPDSRRLLGNSRRPDRSPPPSRSSLGMTLHTNDTPDVRPSLDRASTSSSALSQESILAAQQSHSPHLYDKGMASSHSASSCDVSSASEVDTIHGPDGWSSAPVLGSVHSIGERGRPTTRSGGQSEDEAALASEITLPGVPSERSDSGGTARSGSAGPTFQSRASTRQSQPTIAGAARSRTRSGSVSGNSIRRTISGASAATSNTLTHSSLPPPPSGIASAFRNLSVGGAPRSSSKGGAPPRSSSRGGRFSLAGISEALRGKSTSRVQDSSNARNEMGVRGQSSSSSRRETSPDSSQPATGIITRDQSRGRKTALKVLRAALTAGGGGGFHEGDGGVEGDNDNSDDEVQATGWKEFRAGTYTYPISIAIPVRLPPTISASFGHVAYVLKATVHRAGALTSNLTTSTEIVLVSAPSQDDMEENESIVVERFWETQMKYNVALSGKVRPFLQEFGSSMHWSKADPYIGGVSQSFAIGSQIPVSIRLDPMAKIKVYRITAVLEQKTDYFASGRKLTRHETPKKFPLLRIEHKDPKEPLLPILSDDPKAITDHPLADFFINPDTSDDTTPALLDPLGPWHIESYLQLPTCASKIAFSTHHDQSNIATSHIIKVMLRVERGDDDYLDSKGNRKLWDVIIESPIHILACQCAQNALPAYSAASGGGTRGQNGGPVVGGTIQPCEVHSPPSMIGGPISSNGRRSPSTTRTDRSRSRVRTAAIVAAAAVAAAASPYPHRSESPHPSIPASELEQTNALFARLVAGEEMPSGEVPPTYGATMGGEGEEGEEEGRGRTPVGRGRTRTRDHSVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N1Y8</accession>
    <name>A0A2X0N1Y8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C007g04751 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C007g04751</name>
        <name evidence="6" type="ORF">BQ5605_C007G04751</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY62901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N1Y8"/>
    <dbReference type="STRING" id="796604.A0A2X0N1Y8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028143">
        <property type="entry name" value="Get2/sif1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28263">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28263:SF1">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08690">
        <property type="entry name" value="GET2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY62901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="374" mass="39002" checksum="A53214F2DBB141C0" modified="2018-09-12" version="1">MADDAAAEERRAKAAARQAKLLAKSNERLAKITGAAKGEGRVISDAAVGIAPRTAPSSSPPPPRSLAPRDDDDPAEVDLAAASINARANALAQLNPQQLAQFDQMFGGPGAATGADPFAQMMAQMMGGAGAAPGIGVDPNATAPSPFGPGGANMFANLMNAQPGAAGGGIPAQPGLSAFPPTPKTWLDRVFPLLHLVSMIALSVYAIVYVEPAKKFGQYGWMGIRSKIDWAAWARLGATKPVQGTIAGQVDQLAGVGLSVVPLLWMFVSLELVLQTSRLFLLRNRAPAPSMLNSILPLVSQFSPQIGLLISTIVRYMTLVTVLLNDISVVVFCIGAATIYGKYKTGTFGAGRANVLDRLSQVGHEALDRLKGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N2F8</accession>
    <name>A0A2X0N2F8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C004g02624 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C004g02624</name>
        <name evidence="2" type="ORF">BQ5605_C004G02624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY66105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N2F8"/>
    <dbReference type="STRING" id="796604.A0A2X0N2F8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.40">
        <property type="entry name" value="Domain of unknown function (DUF427)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007361">
        <property type="entry name" value="DUF427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038694">
        <property type="entry name" value="DUF427_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34310">
        <property type="entry name" value="DUF427 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G02220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34310:SF5">
        <property type="entry name" value="DUF427 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G02220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04248">
        <property type="entry name" value="NTP_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF427" evidence="1">
        <location>
            <begin position="2"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY66105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="99" mass="11262" checksum="0824EE0BA9C12638" modified="2018-09-12" version="1">MVKVLINGTVIAESDKTTTADGNHYFPREALKQEYFKPSARNLHTTCPWKGEASYWDIDVGNGKVMSDAAWYYPKAITDRAKDLEGRTAFYKNKVQIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N439</accession>
    <name>A0A2X0N439_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C030g10811 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C030g10811</name>
        <name evidence="3" type="ORF">BQ5605_C030G10811</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000069">
        <property type="protein sequence ID" value="SGZ08700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N439"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33116:SF86">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33116">
        <property type="entry name" value="REVERSE TRANSCRIPTASE ZINC-BINDING DOMAIN-CONTAINING PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="536"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ08700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1111" mass="122049" checksum="D8D892774490CF74" modified="2018-09-12" version="1">MDNNNNTNNASHAAIPPLRPDPPDPPGQAPATTTKSYSAAVGARSAAKHGNATANASTAVAAHPLMHNIENCVIINTPPSTSVEQVLLALDKYYPGLTGAMPCVIKGQRGLRFPKAADLDTLVANGLTVGKTLCKVEKLYSSTRGGVVQCTLTGFFSDPEGLCLFDEQIAAYGTVLRRRIQYIGKTKHISGVYDFILALKDVDVLPPASLSIARDGVTERIPLRITGGMRHCVFCRSAAHVRKDCPVAPACKSCASTSHATQHCPARHASSPQGPPTSRAPQASTVTTAAPAAVSKSISPASAHDRTTKECRVEQDLAAQTEDLSNRAQPDSLSKNARPEFSFNFPCKTATPPAPQPASNQGIAYSLVEKSSESPSSETTSPSPSPPPATPKSIITRSKSIAALSKPATPEPRAVFAHGAALRSRLDPSLAGPSSIFIRLRKVRASDLIPSLTVNDVVHSDPDSMLGAASDYFERVYEDRPIDDAALKAIIDGLASTRLSPADSLKLEEAYPLEEMKKAQAAFLCAVGLGPKARQWYRATYTNQSASIFLNGWLSATFDILSGVRQGDPLAPSLFVLAIEGFACQIRLRVKGIDIAGLQNVRELLFADDVCCALHNLSDLDHLNRAIELYERASASKLSNVKSFLYPLGAFRDRSIAPDLGTWRLSDSQFRYLGIQVGVEIAEDAGWEDVKALTIARIRSIPMYDLPYAAKCSIINIYCYTKILYYSRFLPAPKSVVKEIEEAAMLAIHGRASDGTQRRPKVSRSRLCTPLDHGGFGLIDLPRRLAIDHAKWVFQLRAPDGCFTRHLFDIRIRLQAPNEPTPFTLSRPAPNQHRCPWIWIWWAYFCHPPPKWDHAVRKTTKLLPARWVRYFEAWALVTTLNPPELSKSQNLEQWATHVLYFPAGHGIQLSVNPTLFRGPDGEVMTPSSFVNASKRHQVFIFPLIFPKGHQKVFDLPEQRWNAWWKALRKVRRVHSDAEDTGHLLSLGSLHPGSQVASPTSPHPNNRSTSCVMCLSEAPECLVHLAVGCPFARRLWSALSPTPHPVFVDFVCPVVSRSKRRLVELRVLFFHSIWKLCRRRRFSSDLLEPITETEFEGLRASIQESKGRLVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N4U2</accession>
    <name>A0A2X0N4U2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C028g10534 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C028g10534</name>
        <name evidence="3" type="ORF">BQ5605_C028G10534</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000080">
        <property type="protein sequence ID" value="SGZ12922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N4U2"/>
    <dbReference type="STRING" id="796604.A0A2X0N4U2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990247">
        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057720">
        <property type="entry name" value="RRM_YTH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF3">
        <property type="entry name" value="YTH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25701">
        <property type="entry name" value="RRM_YTH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YTH" evidence="2">
        <location>
            <begin position="577"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="390"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="556"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ12922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="725" mass="77773" checksum="91CBB52FEBEB4479" modified="2018-09-12" version="1">MTNPHPGSADTTCTPRYPADGTENSTSVRTAAFDASTNGFTTATSLEPWKDAFPWSPFDRGAASSRAFRGRAEAEVNSEWSSSFPSLGSTTPSRPLQQPRGSYASADLGSARSHDFSSRDSSASSSCVAVDHPPSTAPPLTAHSVFDPWASETSNGPNRLSSARTALAPRIQDRNASRYISQVAILASTPHADPPPPPILSSYAFSNHPRIDLLSPVPLGDSTFSAPAGSQQSAYASSLTPSSNAPLLTRNSDLRPSSAPWSVAGGSPSAPPHAAMGIHMPLPPIRPADWSAPLLPPTQAIQGGSTRSQSPHELSLTRESYETSPYAPFPRSWYRAPLGTSPAHLESDRSGARAASPAMVTISGPPQLLHLRSANEQLPPLPLSRSNSDSATVSAPVPPSVTASSRPGETRLRSGLPDRSTWAMWCGNIPSDATEAELLDFFAVRGVSAATAADLYGVESIHLIARSNCAFVNYSSEFLMQQAITRSNGVSLRPNDRRCKPLVCRRRMREDDAKSGVGAQRGAGLHLSYIAAQALDLGKKGVRTTNDSRAIDEESGNSSGDSTASTTSSFFSEYFPKRFFVLKAKESEHLQESIRSGLWSTQGHNEDVLDQAFRTSLEGVFLFFSANRSGGFAGYARMIGPIFTPPRDRTGSRHFSPHLAEADKVIIVAEGGTPFPVQWLSTRHLPFTRTRSILNSFNNHREVKISRDGTEIEPNAGLALLRLWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N6B9</accession>
    <name>A0A2X0N6B9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C021g09362 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C021g09362</name>
        <name evidence="9" type="ORF">BQ5605_C021G09362</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000083">
        <property type="protein sequence ID" value="SGZ21394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N6B9"/>
    <dbReference type="STRING" id="796604.A0A2X0N6B9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12324">
        <property type="entry name" value="RRM_RBM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008111">
        <property type="entry name" value="RNA-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033744">
        <property type="entry name" value="RRM_RBM8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45894">
        <property type="entry name" value="RNA-BINDING PROTEIN 8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01738">
        <property type="entry name" value="RNABINDINGM8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="55"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGZ21394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="164" mass="18366" checksum="94ACDD20C523A8E1" modified="2018-09-12" version="1">MSGMDVDNPSDGVERKGRGFASRPADTDVGVVAGYETIRADRSSADRAQRSIEGWIIIVRNLHEEATEEDLQDKFGDYGEIKNLHLNLDRRTGFVKGYALIEYAEKKEALDAIKLASGTELLEMELNVDFAFSQPPARYTHRKRSIIYNVGIHGLIEIACCDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N786</accession>
    <name>A0A2X0N786_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C009g05548 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C009g05548</name>
        <name evidence="3" type="ORF">BQ5605_C009G05548</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY82148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N786"/>
    <dbReference type="STRING" id="796604.A0A2X0N786"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="161"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="689"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY82148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="748" mass="82881" checksum="C291721E4A5D8EC8" modified="2018-09-12" version="1">MLDATGPFVAERGSSNLSSSTSSSRSGGGQDSDLSLNPNHWMHPQDRYRSEEKALLHQKEGYSAENGSLGTTTRLTSSSTPPTIFSARPPSSTLALLTKLPRAFPLGLVALLSLLYLMLSSWPSSITTELSSVSNPATWESSEYFDPIPNSSWSHFDPIDPVVRAASQRFRGRHSDDGVYVSWKGIRYAQAPTGDLRFRTARPVKPTTRPVKEKEWEAVEIQDAYDPGQGCPRWIKNPRREGVWEGEEDCLKLHIFAPAGQEPSKLLPVMFWIHGGGLASGSSLLPRYDYASLMKRSVEMNEPIIMVTFNYRLGSLGFSSTTAALKAGSASRGRNRAVDQALDLNVGFKDQLAALDWVKRHIESFGGDRKKITMAGHSAGAIAVGLHQLYTPDSFRGAFMLSGSPTSFPVPWPHEAARRSTHTLEEAAGCPKAAPGNRGSTYELNLIKCLRQLPLDSLMRSTIGLQRYQFPWYPVVESNSKDAWLTRKPSEMMASVRSRRVPFITGTVLDEGTKFTDAGMESEASIENALRRSFAWVFDSVQDGLLSRLWELYPDVLRHGSPYNTDRETFGLAPAYKRAASILGDLFFRAPKLFFLNEMRDVASTVTASGKQSMWNYLYSYQSPTKFDPKAGISHGADLADWFGKPRPKDPNADQIARIMSAYLINFVANLDPNGVDRKLAHSNAVNCASPPSDRYSSSTPTVPPWPRFSKKGETLHFTKAGRAIVGRDIERQPAIDFLNENNDFFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N8J7</accession>
    <name>A0A2X0N8J7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">BQ5605_C025g10028 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C025g10028</name>
        <name evidence="14" type="ORF">BQ5605_C025G10028</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERT1/acuK family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000087">
        <property type="protein sequence ID" value="SGZ27020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N8J7"/>
    <dbReference type="STRING" id="796604.A0A2X0N8J7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056751">
        <property type="entry name" value="PAS_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF1">
        <property type="entry name" value="TRANSCRIPTION ACTIVATOR OF GLUCONEOGENESIS ERT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24990">
        <property type="entry name" value="PAS_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="12">
        <location>
            <begin position="235"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="13">
        <location>
            <begin position="636"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="291"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="530"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="94"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="530"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGZ27020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="752" mass="80177" checksum="62CF369F6ED5BF6B" modified="2018-09-12" version="1">MQDPSGFTAPPLPSAFPTLTASSSPSRGSTTVGGARSELSLGTFFNPFHSLPRQSPSSSSSRGTTPSLMMIGQKRPGPTVSVAEDVGSVMDLSSNEDEEGEVKEEEEEDGEGEGEEEEFQMEDDDVDSPLSVATTSTTRIHGQAYHRHQGISPSATATSDHKTRSKLTAKAGRLLSSKAKGKGKASSQNNDETNRAAASCLLAAEGVTTTNAIGKKKMGMPRKNGNDKKKKAGRACAPCQKAHLTCDDARPCARCVKKNRASECHDGTRKKAKYLQEVPDELLERKQSNPFLQASGSHSGHEPMLSGGEDGTPLSGIAGDSPEMLMRETSQAQPDPPQPTLSFDPLPFYDASAFANEFGSEAANLEYAILSTMLNGNGFSIDGSNFNPGAAGAGGSGGEVQGMRGQDGSVSGAQSILLQSPLDQSVHDAPPGTNGQASTSMNVGEETPVTSFFGGYRTDTTGGPQHSASPTMNRNVMSPPRLQDTARDLFPSVGVEVERRTSSSNDVNTSGFGGGNLLFASQGVVSEPNTTAAASATTSGGPTASTSAAPVDASGPSARLSVMTMTGEQAYRAVTKPYPYAQSYHYLVKHLKHRFEKNDILRIVRALATFRPSLIALQMPLTEEDETFVERTFQRTLVELNKLISFSGTPTVVWRRTGEICLVGTEFGLLTGWQRNELVGNKFIFELMDPSSVVEYYESFAKHAFESTSLSVEMQCVVLGPKGRPVPCAMCFTIRRSAKEYLICRGQMTYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N9U7</accession>
    <name>A0A2X0N9U7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C055g12637 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C055g12637</name>
        <name evidence="3" type="ORF">BQ5605_C055G12637</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000092">
        <property type="protein sequence ID" value="SGZ29161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0N9U7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1255"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="643"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="551"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ29161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2073" mass="231145" checksum="F1D15D2AD2B3FBE0" modified="2018-09-12" version="1">MSTGDPGSPPPAPPPPVSATSVQPPRDQIPISSKKTQATGPATAAPNYAAAASQATQSPEQQQQQQQRAKALGSLLQAMGAVPGNRMDRWVQAIYFAELYPVATATSLKFSALNANRSVENIFDYALEVTLSHQSASRASHADKTDLVACVTRLLSPISPICFEPGVPLPDHLAAYRPQILGVQHSSILRNGAAHHRVTVGFVTGEARDAALTTPPALTWRSAKARFAKSHRFHHNMVELRINVGVQGVPSMDAIIKSFQLLVQDLSGKGHSCQLVQVLRIISVDNASAFAHVAGDYSAFLHFDDDSLFKRPNTTLKEILPSRIGLPTRGIPVTALRHDYEKEAACGRCHFVGHVGTCGLDQESKRKEAHNGNGNSNTNPNKNTITNDTNIVEAEAPIPVPVVNRIASQNRFAGLEVEEGQEEAVTGQSGQGPEESGEEDAGDKADDEDSEDSEMESEATAKTEVIKLKSEDESVLEDRRGSDGEVISEDEVMADGRGETEGKVATEMEEEEVATEVDDVDEAGGATKAENAEATDLGETNRLDNDDDSDATATAATASRESTPHEPTPPLSPETLAKSLREGEEWDRIRANWVEQARLERDQSIERRLDAETPLVRHNFATWDEDGEIRSINIRGTASKFKKPVMKRSQTAADLSDPSDEPTDAKRVIIKGKSRVVVKDGTEGRRVTRSMSAAAAMPVGVTKVDRGKAKRVAEEKRWSDHEPEDDRFDLNYPLMIKHTIITWNVRRGMGVPEKRRDIYNYLSLFKASAILIQEHFIRPHLWQLIKDEYEGKLFINQHCLTLIPADSPLIDAELLRTHSALDGRLLVTSFRLRGNIKILEINNVYAPVDPKQRAKFFDKLLFHKTQKSHLRLLGGDLNDCPRPEVDRRNQSRRGHHWPILIGKLDSAYTDCIRYKHPITPSFTRPNPNRKRPNSFSRLEYFLLQRTHQKRLDQASTIYDYPKELSDHRPVLIVLALSDDPDATLPQLSLPTTSNQLHRINTTTFKTVEFQRMMEGWLEGASGEEPVGELEVILKACRDRGGEMARRLHRERTERMEYLVGRVQDLEAIPEWGEAETAEWTRTSEELKRAVEERARLLRIRAHVPEIASEERLSRPVHAKLAARNSDSKITALRLSNGELTHDIDVALDHTQAHFQRLYHIEPRDPDRVDRLRDEFLAPIRAARTCDDPRSDPLFLRRLSESQIDLLQRPITEDEVVAAIGTTHPGRSPGPSGVPYELYQTAPKAWAKVLTKAYNAMIERGSLSPKQGQGLVRLIFKRHKKNADRAELSSYRPITLRECDYKIFTKVYVARLNQILPDLLPPQQHGFVKGRRSADASFHLRLLIEELGARGTEFPDAALLSLDQSSAYDLVEHDWIFAIFDALGAPATFLRVLRMLYSGDSTSARYIINGFLTAPVRLTCGLGQGDPASSSVWDIVFQPFLDALHRRNIALNLSIPALHPYPQSRAITSLAFADDVVVAVAGLGSLNLLDDLALDWRHATNGRLNTDKTVVLPIGRRWDPGQRPLVVKAAGESLEWIGLPFDPSGDTELAYANLIERLEATLEGVQHRWLTHHIRAFYVNRYAIPKILHFLAADIPPPEVVKKLDDMLVDFVRGGKGRTSYGRDIVFTAKLKGGLGVIRMQDVVDAVAARIWDVLLGGSGAIWQGLARAALQRAQSDLDLATDLWPHPSTPIPSDLHPRWRAALGVPKQQDAQVNPRTLTTANLLALPTLLGSLHTPIRGRQTIDAVHIPDYLRLQGYPKVADLYRRELYAGGGFYLWTPPADVLGDNSEYDRRGLPQRLAIAAWYRFTVDRHKNTPLAVAVAAGRLNVPPRIGTSAPLEAILPKPVARFAMEQRLPDPVLPQQASQYKLLNMARPYTIRRIRRVLNAKAFTNTLGLKGPPQPDDLRSFWKAVNSKALTAREREVWFKLILRFTPTRKLQNQQKHDTSPACLVCEAPVDDTDHYFFGCVDSRNVWIAARGVLCDALGCDTIEDAQYTTLQRLFGLPKLKAKLSEQEGAGWTIEIFTGMVLEMISSGRWRMQKHGTRMESVERRRVVLEERMKLRAGGARGGRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0ND47</accession>
    <name>A0A2X0ND47_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C021g09354 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C021g09354</name>
        <name evidence="4" type="ORF">BQ5605_C021G09354</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000083">
        <property type="protein sequence ID" value="SGZ21308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0ND47"/>
    <dbReference type="STRING" id="796604.A0A2X0ND47"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23024">
        <property type="entry name" value="zf-HIT_ZNHIT2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="3">
        <location>
            <begin position="8"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ21308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="310" mass="34101" checksum="D6092DD4C8872BFF" modified="2018-09-12" version="1">MPPKLPKCAICQTAAAGKYRCPIDDVDYCTVKCFKKHKEEGCTGSTKAAMTQDAIKDDGAKADLTSTGTGRSRPVYVSMSLGSRADLHSLESTPKATAKVEQDKTEPVPDPTPQQQVKHTLHLESDDRPRKKLKDLHWPPEPDASIFLDPLARDDVKPLRRKEYEAIATSPTIRRLLLTQPSLIPTLSRLLAIPAEPFNSSYHNQSSHSLRAPPPPSARETSLHLLLDLPVNSAPTYYRPSGRTVGSEYRTGSHVSQQGRKGNGLERGDLLGGGRATALVYSTPEERKEVQTFVDEVEKLLNDVRKDGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0ND78</accession>
    <name>A0A2X0ND78_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homoserine kinase</fullName>
            <ecNumber evidence="3">2.7.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C021g09384</name>
        <name evidence="13" type="ORF">BQ5605_C021G09384</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-homoserine + ATP = O-phospho-L-homoserine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13986"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="3"/>
    <dbReference type="EMBL" id="FQNC01000083">
        <property type="protein sequence ID" value="SGZ21581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0ND78"/>
    <dbReference type="STRING" id="796604.A0A2X0ND78"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00384">
        <property type="entry name" value="Homoser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00191">
        <property type="entry name" value="thrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861:SF1">
        <property type="entry name" value="HOMOSERINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861">
        <property type="entry name" value="HOMOSERINE/4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00958">
        <property type="entry name" value="HOMSERKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="12">
        <location>
            <begin position="75"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGZ21581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="394" mass="41555" checksum="2A70D681CC93FE35" modified="2018-09-12" version="1">MVFTAAPVAGERNWVIRVPASSANIGPGFDVLGLALSRHLTLNVNLTPSSAEESQVLLSYDGEGANEAPLDPYKNLITRVALYVLLSHHLTFPAAIVKVDVKNQVPFGRGLGSSASAVVAGVLLGDALGDLKLSQERVKDYALMVERHPDNVTAALVGGFTGSFLRTLDASELAPSSIPLAEVLPAYPANAGPPVPGQEEPPQPPVCVGRHVRYGFSKDIGVVVVVPKFEVETAKARGALPNTYPRADVVFNLQRLAVLTASLSQSPLDANVIWEAMRDRVHQPQREGLIPGLSKILNHMTPATHPGLLGICLSGAGPTILALVSNEKGADSNSGTILTDDSEITLGESTTSGGATPQMTRIGEAIKALWKEEGINVEWLALTVDDEGATLKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NPD4</accession>
    <name>A0A2X0NPD4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C012g06736 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C012g06736</name>
        <name evidence="3" type="ORF">BQ5605_C012G06736</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NPD4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="531"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY16022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="642" mass="68502" checksum="F646F18ADFA42F22" modified="2018-09-12" version="1">MNYVDKRDTQLSRGQHLLRGHFQGLARLKKRQNLAISTPSTSSSSASATSTPKQITIPDGWKSIPRETNYYAVPVIVAISVLVAILVIATVVGSAIWRRKKHRRKRKHPAELEKGRVGKLMEQVGLGSLASRRTRGGRNKQGGTSVKSPRKRLSVAAVAGESTSFQDTAHPNGSEPARSISDGGSGNVNFHRAGPSGRPVGGYRNSTASTIARIRRRREQRAARAAADDDRSDADEDEDEDDESRALTGSHSSRNTPENTLTARIAARLLSAVSQPPSPSPGPSTIFRELDRAPSASTTQSVEDLSRVSSRASTHSHSVFDRGESGLREPFTPAVLYGPNPIRPNRVQALPDTSTTATFGASPATAGLALPIPGPPAYRPSSTTIAMTTRFSPSRAFSSRPAVEDHDPADMWHWPNEKGLSSASVATPFSSGASSSTRTPQESLDIGRSHPATQHDSSIFTAHLATDDKTILARLREQVVNDDAREGPQATSSRTHPLASATAPVLPEDDGEDAWLGFASESDPPVPAPSAPLAALLPAPSQPVATTFDYSAPPSKPRRPGVASVDEYEQAEMGYLPVYERRRNAEANHAHIMARATAPISVPDGPEESANGAISAPGRPEEGANGAEPRVLGLTRLEHREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NPE4</accession>
    <name>A0A2X0NPE4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C012g06746 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C012g06746</name>
        <name evidence="2" type="ORF">BQ5605_C012G06746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NPE4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY16056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="231" mass="24394" checksum="78676C5A8094AB36" modified="2018-09-12" version="1">MVEQGGTNPGGTGDAAGLPNTAPSARDRQKLRAAQVSQDEEGGRASGGRDVSANVCAQLGTHPWPTRNSALRQRSVLDGEKIQSPKFVYDVKALRDNARIIVQRGALLRKADFRSPSSKLKLLGRPGSDHPIAACRRAELQAGGRAMLTGGLGTRAPTSTASEVTMAELSAPAGLVDAHAMRKSWLLKGQNSLDNTGHHNCSLIFCFICIRLLGLLVTKGGEGYCSLALRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NRX0</accession>
    <name>A0A2X0NRX0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C014g07676 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C014g07676</name>
        <name evidence="1" type="ORF">BQ5605_C014G07676</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY19542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NRX0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY19542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="177" mass="20640" checksum="D1CDF27C9426FB9C" modified="2018-09-12" version="1">MRYPQRARGCCFDVLPKLWHRRYNHPTLEIQHPIHTREPWRRVEIALDLLAKGIGVIALHKAAPQLCVDVHLRNRLYGIRLPLRERVPAHRVFHGVLASRNRFVVRKDMEVDTHQVESPLTQGVHDRQKLLFMGRVVDLRTDVLTRPIRHRVCLAPILPLKQHGAYPNVTCVHMAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NT49</accession>
    <name>A0A2X0NT49_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Single-stranded DNA-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C010g06005</name>
        <name evidence="4" type="ORF">BQ5605_C010G06005</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NT49"/>
    <dbReference type="STRING" id="796604.A0A2X0NT49"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="SINGLE-STRANDED DNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302:SF0">
        <property type="entry name" value="SINGLE-STRANDED DNA-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002070">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR002070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY13933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="136" mass="14882" checksum="34069A7163ADF218" modified="2018-09-12" version="1">MIGALRPSATRAFSQSAVSARDLARVTLIGRLGAAPERRQTKNGKDFLMYKVATRDAMLPAQEGATPPEPTTSWHTIFAYGPGVDRLETLEKGALVHVEAQLTVKNSTTPSGEYKTDYFAKHERLMVIRKPTQPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NUE7</accession>
    <name>A0A2X0NUE7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">BQ5605_C013g07317 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">BQ5605_C013g07317</name>
        <name evidence="15" type="ORF">BQ5605_C013G07317</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0NUE7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04044">
        <property type="entry name" value="C2A_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04052">
        <property type="entry name" value="C2B_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04045">
        <property type="entry name" value="C2C_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04040">
        <property type="entry name" value="C2D_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21678">
        <property type="entry name" value="SMP_TCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037761">
        <property type="entry name" value="C2A_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037765">
        <property type="entry name" value="C2B_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037762">
        <property type="entry name" value="C2C_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037756">
        <property type="entry name" value="C2D_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056910">
        <property type="entry name" value="TCB1-3_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017147">
        <property type="entry name" value="Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052455">
        <property type="entry name" value="Tricalbin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46980">
        <property type="entry name" value="TRICALBIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46980:SF2">
        <property type="entry name" value="TRICALBIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24920">
        <property type="entry name" value="C2_TCB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25669">
        <property type="entry name" value="SMP_MUG190-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037232">
        <property type="entry name" value="Tricalbin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="14">
        <location>
            <begin position="249"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="440"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="588"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="725"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="1059"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="46"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="898"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1458"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="899"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="914"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1458"/>
            <end position="1470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SGY15295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1491" mass="161159" checksum="AF3CDCACAB0112F7" modified="2018-09-12" version="1">MSVNGGVAAEAPASVSYNAASTPISQQTKELKELKDEAMGAAVHSFDPDACPEEKAQQAMKGAPSTAPVDMSGVPSLRGKELKDFKEVGGAEMVTDLGTKPVEPTTNLKEIEALATEKEAPKDKLVPPGAMPQGKTGEALREIPDWFSIGWNDGPDKSLYLAPEDARAQSILSDFISDAYFGQWWVNAGIIIFAVVASHFMTLFGGGWGWLIVILGVTATAYDTSIRRTRRNARDDLVREVAKKGLRADVESATWLNLFLQRFWLIYEPVLSATIVASVDQVLQTSTPAFLDSIRMTTFTLGTKPPNIDHVRTFADTEDDVVMMEWKISFVPNDIQDMTQRQASRKVNPKIVLNIRLGIGPAVVGKDIVVEDISFQGTMRIRMKLMNNFPHIQLVDLSLMEPPVFDFVLKPVGFDLSLIPGLSPFITSQVHATLGPMMYHPNTFTLNLEQMLSGAPIDTACGVLALTIYSGRGLKAIKLGGGSPDPYVSVAVAGRAELAKTAIKRSTTTPHWNETKYILLNNLNESLTMTIKDWNEHRADSDLGTASFDLKSLMEDGQQEGINADVIFDGKARGVIKFDAIYFPVLTAKKLPDGTVETIPETKTGVVRLVVHQAKDLDGRGQQINTCTEVRLNDQIVHRTQTLKRSPNPVWERPCEFLVTDRSSAVIGITVIDENAISANTRLGVLKVKLADLLEANAKGQDFFPLSQAKTGRVRLTASWKPVMMTGAISGAGQYTLPIGVVRVLFKRARDLKNVEAMTGGKSDPYMRILHAGIVITRTEVIDNNLDPEWDEIVYVQVHSKKDTFVIECMDYQHLTKDRSLGVTELNVSDLLTEGHDDQVNKPWVSTGKHSRKDGLRIDGKKTVKGSVEYDVEFFPCAHLKNVSFKEPEPDVIEEEVETLTNEAEAETSNTLERNGSISGKSTSTKAEDDTGIVIPREELLKTQTGVLAFQIISGQLSRKGARLEVLFDDGYWPAYSSEPARSTHAVWDEIGEAVIRELNFSNMILKLNAAEKETREDIVASATIPVYQFLTSCLDKSFTFTLTDPNGGSRNTVTMAAKYIPINMVLEPRESINNQGTLSVNLVDAKGLAAGDRSGKSDPYAVFMLNEEKVYKSEVIKKTLAPVWNEKFECDVRSRVAANFYVIVYDWDRVGTPTHLGQGSIDLAALQPLELTEHTVSLYDVKTKKQQGMVHVKLMFRPGFLARSRKSTSTFSSAGRVATSIGGGVAHAGGAVVGGVGVIGKGAVSGVGVVGKGAATGVGAVGKGVFGGIRKVVPGGGGHNNSYQRTSSFGNSSIAEIDFANEAAAAGLSDPAVGNSALMSSVGTPSGATSQVGSLTVTITSLSGASEPREKQVVVVKAGNRQIKETKAHHAEGGQDSINFDESTTVKTDGPMTLEFTALHKKTLGKDKSLGSGLVNLWDVLTPGGPPTTVTVPLTGGAGSLLVGLSWMATLSQDSDTRSIAGSVSPSTRKSSRFSPARFGRHRDSSVDPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NUT1</accession>
    <name>A0A2X0NUT1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="26">BQ5605_C012g06710 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">BQ5605_C012g06710</name>
        <name evidence="26" type="ORF">BQ5605_C012G06710</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY15947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0229">DNA integration</keyword>
    <keyword evidence="20" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="18" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="21" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="17" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="18" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="19" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="25">
        <location>
            <begin position="540"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="24">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="SGY15947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1414" mass="155859" checksum="8EE686331C33B72D" modified="2018-09-12" version="1">MDSSPAPPLPPRDTSSPDPSISVQIATLQAQLTALQASQPPAAAAAATPPVTATQANTATTSKVVFPKHARLDGPKSFTNWLCQLRLALPNQARGYVLDGVIPPTWTADQLAARDDAAREIIVGSIDSADVSATLDTIPSNDLSAPHIFAALKARFAPDDATRTLELFARLWDFRKMPASVEAYDTWLREYMSIAQEIRDAKTSLNDVLAMVPSCLDSFRLTFTDEQRNRRDLPELTTLTDHIHIQLCSAGLSSSHSARLAIASPCPACRAPGHRLRDCTSRAKHPPAGPCRRCHKKGHWALDCKHRGEQKHTGDDNQDDMSLPAAQQPNVGYFASCLFARRQLPPDAFVVDSGATAHMVADRSLFTAYCQTAHTKIGGIAGGITAISMGDVAFIAKTRHPITLCGVLHTPGLHINLLSVSRLCDTNRVRLAFTSNGIDIAKDGQAIAHGTRVNDGLYLLDADHTKCQQLAFLSRSESTVPLLTLHRCLGHLAPSSIQKMIAAGLLDGFGAGYGDKDVEEFVCNACLGSKGHRLPFPNSESHSPERLGLVHSDVLSFPTPSLTGKRYLVTFLDDHSRKLWAYVIDHKSDIFPTFQTWLAEVELETNARLKTLRTDNSGEYQSNTFTEFCKSRGIHRQYSIPYTPQQNGRAERVNLSIIEGVLALLADSHLPATFWDEAAAYFVYCKNRCSHSALAKQTPESVWNGQRTTATALHPFGCAVWLTVAPDLRSKLDPKAARVIFTGYDLASKAFRFFDHSTNKVVIGQNATFLDDDFPGLPINTPVDADNTERQFVIPADTPAPTVKMWTPLVSLDSEPVRLESNLVPFTSLDDSDDPLDLLNSNTAVCLNLMNVHQSDDNTLVTPAPAIAPAGQPSDDDSPDEIDFLSRHHRAFIAAEDDDPALKAIEPIKSITSDPQTWREAMSSDEHNIWAQAAAAEFTAMRDDFKVFTIEPRSSVPPGATIVTSKFVWKTKRDARGDVTGRKAHLVAQGNRQRDGINFSETFAPVARFSSIRCLLALAAANGYHVHQANIDKAYLHGELDHDIWMTTPRGFDFLSDKVLRLRRSIYGLKQAGRIWNRHIDTSLRSLGYKATGTDHCIYSHIDDQQRPHYIALYVDDLLIVSPVLDEIERVISGLEQQYGVKRLGPAEYILGIQIRRLDDGSIALSQERYIMDMLARFHFDTTTHSATVPMTPGLSLTAVPGQGTERIQSWYLQAIGSLLYISLGTRPDIAFAVLYLSRFANNPGRRHWIAIKHVLCYLCATYRDELLYARGPAKVTGVVGYSDANWGACIDTSISTMGFVFYLAGSAVSWSSKRQTWVADSTTDAEYLALSHAGKEAIYLTQLLSELHVRPIDAAHIFTDNKATAAVAHDPVRTSGTRHIHLREHFVRDMVNQGNISLSHRWAPRFLVHIVML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NXK4</accession>
    <name>A0A2X0NXK4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g01936 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g01936</name>
        <name evidence="2" type="ORF">BQ5605_C003G01936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY37994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NXK4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY37994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="109" mass="11850" checksum="82445D61B4C5F903" modified="2018-09-12" version="1">MATLVYRKTLDPVVVHHKIGKKTNVLLPNILQAQTQLVIGGAEEHSRWLQLGDLQPGATLEQAVAALGKAQEEETRKGWGAAGARRSLRSGSKAQNVDVESKFNLPLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NZ55</accession>
    <name>A0A2X0NZ55_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g02576 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C003g02576</name>
        <name evidence="1" type="ORF">BQ5605_C003G02576</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY41861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NZ55"/>
    <dbReference type="STRING" id="796604.A0A2X0NZ55"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY41861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="108" mass="12073" checksum="5DFF91F3625EF799" modified="2018-09-12" version="1">MMERLGRGTGVLARANVKPSLALTLARSSARETLFYQHVFPHLPDHLRKHLPQYHGTYRGTNGNGYVMVFEDVGTMMNELSDFYGSPRCGKFLKSGALNPATTTTRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NZI6</accession>
    <name>A0A2X0NZI6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C019g08922 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C019g08922</name>
        <name evidence="2" type="ORF">BQ5605_C019G08922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY23272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NZI6"/>
    <dbReference type="STRING" id="796604.A0A2X0NZI6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019341">
        <property type="entry name" value="Alpha/Gamma-adaptin-bd_p34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14659">
        <property type="entry name" value="ALPHA- AND GAMMA-ADAPTIN-BINDING PROTEIN P34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14659:SF1">
        <property type="entry name" value="ALPHA- AND GAMMA-ADAPTIN-BINDING PROTEIN P34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY23272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="375" mass="40910" checksum="17B9DA09AD08DCC0" modified="2018-09-12" version="1">MASSLPSCSTILVYSLSSIPREQVDQIIQTAATTHDSHPTSTNSTRGPRFWTIRNKYYTCEVQFVHVLQAKDGEGRGDDQGGYQLQGDEPAVIVVAPPTQTPPTDLENLLSSLAARDPEFDIALLLTSPSPPTDQDQILISPPPNDQAWDDLSLNHAFEYVPPSSSSSPILNLTSPSTFKTPANADDDDRGEKRGPERVIEVLQSRIWERMIPSERTVQATTVKSDKSTLLSLLPPPTLPKAKEYSPVRVDWPEKFLPNLVAKRGEWESKLQGGPEGGGFDDDFTEFVSGPSGAEVGRWDQISSASTSEFTTTPGSGSDAEGVDDDDDFATLELQDQELESLFAQLGTAREYALGIKDLDEKRAFAEKTVLSLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NZN9</accession>
    <name>A0A2X0NZN9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">BQ5605_C016g08251</name>
        <name evidence="17" type="ORF">BQ5605_C016G08251</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 19">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cytoplasmic vesicle</location>
            <location evidence="14">COPI-coated vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SSU72 phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY21541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0NZN9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030663">
        <property type="term" value="C:COPI-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000003">
        <property type="entry name" value="Brefeldin A-inhibited guanine nucleotide-exchange protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.20:FF:000002">
        <property type="entry name" value="Brefeldin A-inhibited guanine nucleotide-exchange protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000182">
        <property type="entry name" value="RNA polymerase II subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000039">
        <property type="entry name" value="RNA polymerase II subunit A C-terminal domain phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015403">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006811">
        <property type="entry name" value="RNA_pol_II_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046455">
        <property type="entry name" value="Sec7/BIG1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF375">
        <property type="entry name" value="LD29171P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20252">
        <property type="entry name" value="BIG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09324">
        <property type="entry name" value="Sec7-like_HDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04722">
        <property type="entry name" value="Ssu72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SEC7" evidence="16">
        <location>
            <begin position="1006"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="234"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="550"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="871"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="942"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1395"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="2154"/>
            <end position="2195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="564"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="591"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="639"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="877"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="948"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1401"/>
            <end position="1413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00060451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="SGY21541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2389" mass="261696" checksum="2B950B2CE243F420" modified="2018-09-12" version="1">MADDDSAPATTSASGSVMPSSTSDPAQSTSAQDTTAAPETKPVPQPADEPKLEPVLEPELETPALLVAAPVSSRPKIDIHSLERPMVDEERLVTPEGPPEDEVQALDRLASDATTSRLGAATGTSTTTATAEEQVQPRSEVHGADATPSPPSRTEINQFESVNGIDETPDGPRVEHPSEQSASTRASATSTNGNQVASERSLSEPPITPSEFEDVQLSTSTPVALPASVLADAAAAVAEVDPQPARSQTPPPAVPTKANPTPERVASLSVPVHGSSSSRVVSFTSSPRIDSAESQPHRSSIASTTTISAPGSHSLVSGILVISALETIGASKEAKKSKPLKDAVDVALEALRHPQGSTSAGSGSDGTVDPHLVFEPLRLACESKSLPLMITALDCIGKLVSYDFFVDQRPPSHYAVNDAASATNDEGESVGSANVPIDQIPLADLVTSTVCDCFSPSPAGATSNSTSAGGAGATTPHDTLLLRLLSSLLSLILSTSLEVHQSSLLKAVRTVYNVFLLGRPGTVQTVAQATLGQIVGGVFGRIKLGPQSLIPGDVTPATAADSVNGKSGYSSRNGSLAGSKADLASVEEEGEATKEKADVAEQNHTEKESESLEAPQVVVKEAVAEGETSEEQKEDAATEASTSAPAHENVNTATTDRQRSFEGTPIMAGGDVTVNRNDLYIKDAFLVFRALCKLSMKPLGSDSERDLKSHAMRSKLLSLHLVLNIVNNYLPAFVDPYVSIISSTSRDRTPFIQAIKQYLCLALSRNAVSPVIQVFELSCEIFWRVLQGLRTKLKKEIEVLLNEIFLPILEMRNSTIKQKSILLAVFGRVSQDPQALVDIYLNYDCDRSSLENIYERLINIVSKLGTTQFPASTDGKAAAQPSAASTSPFPTPGPTLSDDSRMTDPALSHLTPEMHLKRQALEALVTVLRSLVSWAARGGATTTTMTGSEFNGSMNANLPPTPRSEEADTDYSDTPRRSLGAAPASVDLSRSRAQTPDVVPADDPSRFENAKQRKTTLLEGIKKFNFKPKRGVSFLIETGFIRSNEPKDVARFLLHADGLDKAQIGEYLGEGDAENIATMHAFVDLMDFTNTAFVDALRAFLQSFRLPGEAQKIDRYMLKFAERYTAGNPGVFANADTAYILAFSVILLNTDAHNPQVKKPMSKVEFIRNNRGIDDGNDLDEALLVGIYDEINRNEIRMKDEVEAAGPQGGASGIANALATVGRDLQREQYVWQSEGMVNKTEALFRTLVRGQRRGAPAASAQFYSASHFEHVKPMFEVVWMPFLAGISAPLQTTDDMDLITLSLQGFKQAIKIVCLFDLELERNAFVTTLAKFTFLNDLGEMKAKNVEAIKTLLDVAMVDGNYLKGSWREVVTCVSQLERFQLIAQGVDSQAVPELGRKPSTASRRSTLTSRARNSRPTEQVALETRSQHITITADMIFSSTPNLSGTAIVDFVRALSEVSWEEIQASGLAEQPRVFCLQKLVEISYYNMNRIRLEWSQIWLILGEHFNQVTCHTNAKVSFLALDSLRQLAMRFLEKEELANFRFQKDFLKPFEYAMVHNNNPDARDMVLQCLHQMIQARVQNLRSGWRTMFGVFAAAAKVLNERIAVQAFDIVQRVNREHFARIVEYGSFADLTVCVTDFCKISKYQRVSLQAIELVKALISMMLECPQCPLSENAVVKFEASPNDDPMLRFWFPILFGFYDVIMNAEDLEVRKRALDYLFETLKTHGSKFPPEFWDTICKEVLFPIFAVLRSRSDVSRFSTHEDMSVWLSTTMIQALRNLVDLFSFYFDALARMLDRLLDLLCECICQENDTLARIGTSCLQQLLENNVEKLSPARWERIVSTFVQLFKTTTAFQLFDENLLLPESTDTPAESTDSVAAATNGFVAPTPLSPPTEDVPHVRAPVTDRRRIFRQIIVKCVLQLLLIETTHELLQHERVYTTIPPAELLKLMSALDDSYRFARKFNADKPLRMALWKVGFMRDLPNLLRQESTSAATLVNVLLRMYNDSSTAAHVGKRAEVVEVFAPLGLDVLANYVSLNPDSQARNIAAWTPVCAEILQGFCSLEDEAFKAQLARLYPLVTNTLVRDMDPTVRECVRAVYVRIGRSVLGIGGTDSAGTSTTGPAAVIEEPVTSSRLLPFRSWLLEVAAGARFDGPNASRSTTPPPPPPPLREKPFEPPTTPSLGDPFPPSTKDTKNGHRLTFCVVCASNQNRSMEGHNVLSKANFNVISAGTGSAVRLPGPAIDRPNIYTFGTPYEHMYQDLKAQDERLYTANGLLNMLDRNRRIKTAPERWQESQKVADVVITCEERCYDAVCDDLLTRGGEMNRPVHIINIEIKDNHEEAHIAGKAMLDLCSSIEAAKDLDEEMNSIIEKHMAKHPHQLLHTVLYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P3B0</accession>
    <name>A0A2X0P3B0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g02100 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C003g02100</name>
        <name evidence="1" type="ORF">BQ5605_C003G02100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY38900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P3B0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY38900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="136" mass="15642" checksum="7BCA8EA0E5B5C4E4" modified="2018-09-12" version="1">MPVHLHLRGFLVRQFAVQDVMTGINDESTTVSTKTASTGNAAGQVRLEDGDDGEEVGICGGSLCLLFSLFFVGASWTANFILASDSRFRVSDKLRRRRCEVNTKRMIWERTRAFNREQQAQWEEHQERMLQFTQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P479</accession>
    <name>A0A2X0P479_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C004g02741 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C004g02741</name>
        <name evidence="1" type="ORF">BQ5605_C004G02741</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY67071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P479"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY67071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="59" mass="6414" checksum="6B4A450E60DD0965" modified="2018-09-12" version="1">MDGNTWGTKAVRLDTDEDDMIGGSATKRVCLCSVVGRLERARSRQGKAGVGWTRPDVPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P4I9</accession>
    <name>A0A2X0P4I9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Threonylcarbamoyl-AMP synthase</fullName>
            <ecNumber evidence="3">2.7.7.87</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">L-threonylcarbamoyladenylate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C004g02851</name>
        <name evidence="14" type="ORF">BQ5605_C004G02851</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SUA5 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="3"/>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY68117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P4I9"/>
    <dbReference type="STRING" id="796604.A0A2X0P4I9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11030">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="Sua5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038385">
        <property type="entry name" value="Sua5/YwlC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005145">
        <property type="entry name" value="Sua5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050156">
        <property type="entry name" value="TC-AMP_synthase_SUA5"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00057">
        <property type="entry name" value="L-threonylcarbamoyladenylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490">
        <property type="entry name" value="SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490:SF16">
        <property type="entry name" value="THREONYLCARBAMOYL-AMP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03481">
        <property type="entry name" value="Sua5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="YrdC-like" evidence="13">
        <location>
            <begin position="57"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGY68117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="503" mass="53288" checksum="23C13C29DD8DBA6C" modified="2018-09-12" version="1">MQRTLARVLRTPSSLLKSSSDPTSISLSSTNIMLMESPITSSYVAEPTAPILSDSSPSAIAEAASILRSGGLVAFPTETVYGLGASALSSSAVRSIYAAKGRPSDNPLIVHVSSHQMMLDLLPGAEKAIPAIYRPLMRKFWPGSLTLIFPLEEDVHGPPKNRVAQEVTAGQPSLALRMPSHPLALRLIQEADRPLAAPSANLSSRPSPTSVKHVEFDLGKGRGLGAIFDGGECTVGVESTVVDWVRSGGNERGEEDSVGQLRILRAGGVTAEEIEECLEEAGFGGGVGDKGKGKQKGRGRVQVYARDFKSSELEAKPTTPGMKYKHYAPTHSKVVLVRLSESKAALGLNELIERIREQGPDGRVERVGLMLCSDSMERLSPTTTQEFCSSCSLVTLGMNRSSKASSANDSGMPTLPKFYSYPLGSRSRPIEAGQRLFAGLRYLDSLPASNGLVSKDGGSDADVTTVGVDLILIEAIEQTGVGLAVMERARKSAGGTEVVELGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P4T6</accession>
    <name>A0A2X0P4T6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00075 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00075</name>
        <name evidence="2" type="ORF">BQ5605_C001G00075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY43879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P4T6"/>
    <dbReference type="STRING" id="796604.A0A2X0P4T6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050620">
        <property type="entry name" value="Thioredoxin_H-type-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10438">
        <property type="entry name" value="THIOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10438:SF468">
        <property type="entry name" value="THIOREDOXIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY43879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="109" mass="12012" checksum="7632B06793279975" modified="2018-09-12" version="1">MPVQSIKNEAQYKEIVGASGLTAIQFIAPWDEASKTLAPKFDGYSSSKSFANVKFYKVDINDHEDIGMASGVKNHTFWFLKDGQVKAEFKGDNYAALERALAGFAKDQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P6C9</accession>
    <name>A0A2X0P6C9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein transport protein SEC23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">BQ5605_C001g00635</name>
        <name evidence="17" type="ORF">BQ5605_C001G00635</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 14">Cytoplasmic vesicle</location>
            <location evidence="1 14">COPII-coated vesicle membrane</location>
            <topology evidence="1 14">Peripheral membrane protein</topology>
            <orientation evidence="1 14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 14">Endoplasmic reticulum membrane</location>
            <topology evidence="2 14">Peripheral membrane protein</topology>
            <orientation evidence="2 14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Golgi apparatus membrane</location>
            <topology evidence="14">Peripheral membrane protein</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the SEC23/SEC24 family. SEC23 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY48272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P6C9"/>
    <dbReference type="STRING" id="796604.A0A2X0P6C9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11287">
        <property type="entry name" value="Sec23_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.730:FF:000001">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.380:FF:000001">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000006">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000043">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037364">
        <property type="entry name" value="Sec23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037550">
        <property type="entry name" value="Sec23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141:SF0">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 14" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="11 14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0813">Transport</keyword>
    <keyword evidence="8 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CAP-Gly" evidence="16">
        <location>
            <begin position="350"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="SGY48272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="823" mass="91690" checksum="6B3B6617210B6C0B" modified="2018-09-12" version="1">MGAPQGQYQQHAQQGAYPPQGQPGQGLDPQQQAAPQRAFDYEDVEDRDGVRLSWNVFAGSRIESTRTVVPIAALYTPLKERADLPPVLYEPVTCKTCRAILNPYCQIDVRGKLWICPFCLQRNAFPPHYKDISSNNLPAELLPKYTTIEYTLSRPAQVPPIFLYVVDTCLDEDDLKALKETIIVSLSLLPPQALVGLITYGTMAQVHELGYSECPKSFVFRGSKEYSTKQITEMLGLTAAVRPGGPAPPNAPPPTVHGAARFLLPISQVEYGLTNVLENLQKDAWPVASDKRAQRCTGVAMSVAVGLMEVCPCPITNPWSPINSLLTPRAPYVQSSFPNTGARIMLFAGGPATEGPGMVVGVELREPIRSHHDIERDNVRYFKRASKFYESLARRAAQNGHAIDVYAGCLDQVGLLEMKSLANFTNGYMILADSFNMSLFKQSFQRVFVKDEQGHLQMGFNATFDVQTTKELKVSGMIGHAISANKKSNWVGETEIGLGQTSAWKICSLSPKTSNAVYFEVVTPAGQPLQPGARGMIQFVTHYQHTSGHFRLRVTTIARNFAEAGHPSISENFDQEAAAVLMARIAVFKAEIDDSPDVLRWLDRMLIRLCQKFAEYRKDDPSSFRLNENFMIYPQFMFHLRRSQFLQVFNNSPDETAYYRHILNSEDVNNSLVMIQPTLMSYALEQPPEAVLLDSISIQPETVLLLDTFFHILIFHGETVAQWRRAGYHEQEGYENLAKLLDDPKEDAQDLLLDRFPIPRYVVTDQGGSQARFLLSKLNPSTTHVSGASQYGGAPQGAAIFTDDVSLQIFMEHLKKCVLLASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P8A9</accession>
    <name>A0A2X0P8A9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g04071 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g04071</name>
        <name evidence="2" type="ORF">BQ5605_C006G04071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY55753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P8A9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY55753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="246" mass="26605" checksum="11A30511EDCCFB40" modified="2018-09-12" version="1">MMNMVVTLQKMNNNSLPWLPKSKLAEPIYAQLNNARWLSARQARVATDKRGPAANLELINSHNLGLEETGQSRRFTFATRSGTMCLGLTLTTGQIPSNPLGSFHILKLSLALLQSSSRASTTRHPAPAAQLPDPAFSRSTSSDARTSRSSPVHANDRNGGGLLTPAARSARGRLSGAQLGLQKSASHAPSPSPAEAMQLMPTSKEKNRKGKDVQRFESGEQAEEEDWGKSASVDLPGRRRRQSERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P9F3</accession>
    <name>A0A2X0P9F3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C007g04442 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C007g04442</name>
        <name evidence="2" type="ORF">BQ5605_C007G04442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY60508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P9F3"/>
    <dbReference type="STRING" id="796604.A0A2X0P9F3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015075">
        <property type="entry name" value="AtaL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08982">
        <property type="entry name" value="AtaL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY60508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="160" mass="17708" checksum="974C93AEE196363E" modified="2018-09-12" version="1">MSAAPTSPPSFAATRPINPPGAEPRLTKAEVWKALTIKTREPKEFVPMIRSCKVVKEEGNKITRHVKFGSASSPTTIEECTLYEPTIVYFDMTTAPHGHIINLVSHDPQGELQLTYSFSNGVPTLSKEDVDNVDKANKVIGDLVQHSIDTMRKLHKEGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PAT0</accession>
    <name>A0A2X0PAT0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA polymerase</fullName>
            <ecNumber evidence="5">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C004g02756</name>
        <name evidence="7" type="ORF">BQ5605_C004G02756</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DNA polymerase type-X family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="5"/>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY67211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PAT0"/>
    <dbReference type="STRING" id="796604.A0A2X0PAT0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="entry name" value="DNA polymerase, thumb domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028207">
        <property type="entry name" value="DNA_pol_B_palm_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018944">
        <property type="entry name" value="DNA_pol_lambd_fingers_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022312">
        <property type="entry name" value="DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002008">
        <property type="entry name" value="DNA_pol_X_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276:SF42">
        <property type="entry name" value="DNA POLYMERASE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14792">
        <property type="entry name" value="DNA_pol_B_palm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14791">
        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10391">
        <property type="entry name" value="DNA_pol_lambd_f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00869">
        <property type="entry name" value="DNAPOLX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00870">
        <property type="entry name" value="DNAPOLXBETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81585">
        <property type="entry name" value="PsbU/PolX domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3 5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase X" evidence="6">
        <location>
            <begin position="238"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY67211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="579" mass="65152" checksum="7D1C3B45ACA3D5A7" modified="2018-09-12" version="1">MSPIFARRLSKAPPSLDRFASFRRLLATSICTPSTTQQIEATATHHMAHSLRAQHLRSLSPPKPLSLTRQVGLHLDVIVHVRRNVLASKDASRWDPVKVGFHSGVSVVRDLEQVGSSIVGLEARRSGAVDSTLEGLQPLLPTEIRHFGSSIRSGPILGLGTSSAGSKRALTPFASARAPAGSLHSRLYSTKALYVAKTVDFVTNLSQTYGLDRPVPLQEIMSQMRDIQLLQSYQETKALSARGFKDAVRTLYPLWHRVDQCRDKEVVRMKDLVKVLSPCFTVPWAEISHILGKGKASKLSYMNMEQKTCVLFMRVYNIGRARAKQFYAAGARTLEDLLKLNELGTIKLQESQIIGIKLLDDFERLISRSEMDELKAEIEVCLKSIVTGDEKLFETELLGSYRRGLDFASDLDLAVRHPSFTDSEDKEKARRLLDQIVEALEASGLLANQYRLAHGDKKYMGLIKLKDGQHYRRIDIRLGPYDSYPYMLLGGSGDALLMKLMRHRAKARGMCLNEYGMGDKFEREDQNPNGFRPGTMRIVTNEREIFDLLGVPYLEPHEREYSHWRQKYIDAGIDLAAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PFR1</accession>
    <name>A0A2X0PFR1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C009g05629 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C009g05629</name>
        <name evidence="4" type="ORF">BQ5605_C009G05629</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY83317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PFR1"/>
    <dbReference type="STRING" id="796604.A0A2X0PFR1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="109"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="191"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="286"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="475"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="568"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="670"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="299"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="349"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="418"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="444"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="475"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="568"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="587"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="698"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="734"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="760"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY83317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="773" mass="80701" checksum="E12E2515DB3C2A27" modified="2018-09-12" version="1">MKQDLIASKFDIDRTTVSKILRDKTKWLAIVGPRPETAVAESPDSAATPSAGDNPSSPPSVATPHQSLTFPRTPHHGAVTSSTPMSMTSSISGLFSELSTTGTPSISHNRSSSDSTGISKIDSEVLNWVQSSMRIGAEPSDEALKTKAKEVAKRHRGLEMFKATGAWLDNFKTRTGLGRLLTARNTIVEESNLSDVSEDHLESHDDDDEHAEGGDRTQRGKTKKSKRQSILRRNHNEGAAASSSPLKSSETFGSSGGATSLPNTLKASKMEVDSRTPLRQAFAGSMAGDTSLDSEATPTHSTVHSRATSATASASTDQEFNEAFAQYGTESTGSSIDQRRASPYGKGPTMSTPSRSGSFGSNKSLSTNGYSPSDPSQSPFAFGGFPPDGNNANAFGNPFPHSNSGGSGSNGTDYPLKSPFQTSSRQSSSQSLYSASFSAASGLPGSTDNSPQATYNPHGRSFSIASSTSSFSGLTAFSSQTSQGTPLSTSMSHSQSSSVPSTPAMGTSGYYSHGPTGTLSQLQAAFGTGQAPQAPVQISPQTVAPYLIQGGASEQSPQRIGLARRQTISGFPSPNSFQSVDLAPPSRVQSQAASQQTLRRPSTASISDFAIATTAPGSGSSTPVTALQAFEGLMMAHRWLNSQDASGFTQPGDLIASSDLRNRLAERLGLDLPSEAPGPLPRSASMSASMSLPGSRGATPSLSSSTTSNASAIHTGGKVQFPKSPSRPTRMRSGRTQSTSSIPQFSRSHSTLSLLDASTAEESQQHSHVSLHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PFU2</accession>
    <name>A0A2X0PFU2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Glutamate--cysteine ligase</fullName>
            <ecNumber evidence="3 11">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Gamma-ECS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Gamma-glutamylcysteine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C025g10007</name>
        <name evidence="13" type="ORF">BQ5605_C025G10007</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cysteine + L-glutamate + ATP = gamma-L-glutamyl-L-cysteine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glutamate--cysteine ligase type 3 family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="3 11"/>
    <dbReference type="EMBL" id="FQNC01000087">
        <property type="protein sequence ID" value="SGZ26952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PFU2"/>
    <dbReference type="STRING" id="796604.A0A2X0PFU2"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000009">
        <property type="entry name" value="Glutamate--cysteine ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.960:FF:000001">
        <property type="entry name" value="Glutamate--cysteine ligase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000002">
        <property type="entry name" value="Glutamate--cysteine ligase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004308">
        <property type="entry name" value="GCS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164:SF0">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03074">
        <property type="entry name" value="GCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="5 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="533"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="537"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="565"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGZ26952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="738" mass="83313" checksum="8D1F41C02236ED35" modified="2018-09-12" version="1">MGLLALGTPLEWKDAKQHADHVRSHGIEQFLKIWHRLKDRTGDSLLWGDEIEYMVVSYDDEHKNARLSLRQTEILEDLQADATERQTRMPGREACIPVFHPEYGRYMLESTPGAPYGATLEDLLSVEGNMRFRRVLAKSRMKANEVPMTLTSFPRLGAPGVFTDPYYPPGGGVSRSLFLPDEIINPHVRFPTLTANIRRRRGAKIAINMPIYHDTNTPKPFIDPNIPFDRDIWPEDRNARDGAALPDHIYMDAMGFGMGCCCLQITFQACSVSEARRMYDAFVPVGPIMLALTASSPIFRGLLAGVDCRWDVIAGSVDDRTEEERGLKPLRDDRFVIPKSRYDSVDCYIYDCDSNRPEYNDNHMPYDEAIKERLMADGVDPLLSTHFAHLFIRDPIVIFEETMNQDDERSSDHFENIQSTNWQTVRFKPPPPESPIGWRVEFRSMEVQLTDYENAAHAVFIVLLTRAIMQLGLNFYIPISKVDENMHRAHRRDAVHSQKFYFRKNLFSPAPGHGCSPVPPSNPSLINGLNKHLKEMSSSSTSSSNSTSFSRVTPNGVPADIVEQTCSSHTTTPRSHSPVEGETPSFGPVEDEYDEFTINEIINGSPSKNFPGLLGVVTLYLDGLTDVHPSTRAKLDQSLELIKRRADGSLVTTATWMREFVQKHPKYQHDSVISQEINYDLIRAVDQIERGIRKEPTLLPEDFVGTDDGLRKDDPFMSACGQALALDKGAIVERALGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PHR1</accession>
    <name>A0A2X0PHR1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C032g11118 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C032g11118</name>
        <name evidence="1" type="ORF">BQ5605_C032G11118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000067">
        <property type="protein sequence ID" value="SGZ05242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PHR1"/>
    <dbReference type="STRING" id="796604.A0A2X0PHR1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ05242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="234" mass="25629" checksum="9C656987739F4355" modified="2018-09-12" version="1">MPAPGPSLAPETSARMRIMAREVDSFHDAMYKIVPPLDAPAFKANIKALGKVAHVAPGIADGKGFDFGIKDPPSERHIAKNAPLTEEQQLVMDGEMEHAVGPFRMNPISYVPTRSEVESVTGPLRQCIANGERKAVLRARRLDRRTYDQLEYRRRFLSSEGPFSTSFEALLIPSKLALASDACMRGLGIVVNGYSAYFALPEGWTDLPPPRHSVSITNAEAWAVEALAEAALRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PIW3</accession>
    <name>A0A2X0PIW3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C028g10528 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C028g10528</name>
        <name evidence="1" type="ORF">BQ5605_C028G10528</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000080">
        <property type="protein sequence ID" value="SGZ12824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PIW3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ12824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="59" mass="6376" checksum="14D2F9F7AFBF148E" modified="2018-09-12" version="1">MRISRKAAIGCLIRSARLFSEAWRCAPTVVFSPRLNYTLVSLLSGHSNIDLPSGGLATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PPV5</accession>
    <name>A0A2X0PPV5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C060g12723 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C060g12723</name>
        <name evidence="3" type="ORF">BQ5605_C060G12723</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NPR2 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000136">
        <property type="protein sequence ID" value="SGZ35395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PPV5"/>
    <dbReference type="STRING" id="796604.A0A2X0PPV5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009348">
        <property type="entry name" value="NPR2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991:SF10">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991">
        <property type="entry name" value="NITROGEN PERMEASE REGULATOR 2/TUMOR SUPPRESSOR CANDIDATE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06218">
        <property type="entry name" value="NPR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="494"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="538"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="635"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="508"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="581"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="643"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="658"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ35395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="683" mass="75968" checksum="AB46067149859A0A" modified="2018-09-12" version="1">MPLLMKERLQGQSGEYLPRLIAVMYCVFDPIAGPTVVEQVPEGSVATALSTFPKSAPISSSRPRAGAETSMERSALLNRQRSTTRARSSTQGGTATDAVVRSTSKQRLTATPVLFDFSPIREFVIPKPELCGHLITKATRTCKILGFPIRIVDEEKYNSTRSIYNRNAFIFNVCFIFERDAELSVFEPVVRKVARTLRILEESSSLLSDPPPHFSMGNLLEQLYMDLNNFSEASIRIGDFELELFLSPFYANPKPIKNSDVPLAVCALEQMKHPSWDVTLYKVRWSLLLPVPPELTRPALRPPQICSFINGINHVKGIAELAQVDLHLARLSIQHLVFYGAVIIVDLFQYTNSYATLPLIADVVHTMDEAEEDEGIQNLDSECQAYVYTGAMINPMLASATPPTATTNLEGSSVGSLPNYPSPSSAPVPFANLLGYYAQLRPGVTVTQWCEKLGLDGLPIDVRRLVQFGCIKGFLRRVYTYPVWLDHPKFLKHRNRGRHGDDVEGDEGTTSFFLPTPSNETPLHSAISTLSRMETNDASLLDPPSSGILSRPNRSKTTFHPSATPAKTRAEVRQSARKGRSSGSPATTNVPPISRFPPSLPMMMDGTYHTDEICVKYSISFKQLEVIFRTLGKGRSGKYEGSLGEEERGEEEEDDDDDLRRRRDDESLHSGSNYGDRLVLLYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LP52</accession>
    <name>A0A2X0LP52_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">BQ5605_C011g06463 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">BQ5605_C011g06463</name>
        <name evidence="17" type="ORF">BQ5605_C011G06463</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LP52"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="16">
        <location>
            <begin position="262"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="SGY12315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="964" mass="108897" checksum="56FABC2443BB218C" modified="2018-09-12" version="1">MRSKSKPVESGMNSAEMRNMMMILRLKYDIPTMDDLWDILPRDHALHAQLPGYKLHTLKKTTQRSSQNFVDLTEEVAVFHGGSVTSITLWGRMQTTTPRTIYAMDFGSSLDEGWRRLEGAGASAVTLLGSGNEMRNTQGTVNCKMARFVRMSMEADNSQRAGEVVCFVELGITTLKEKRLLLLVDVFPVAMDIRGLYERFNVDGPRNLSLIGVEHLRQLVSIIPNTMRSPPTICTASCSDLKCKLCLASKATHKPFPNSESRAGKPLDLVHIDLLSFDGELSLANHRYALVVVDDCTRYMWVLTMPQKSDSFERFKTWKLRVELSSGHTLKVVRSDRGGEFLTTEFKRWLDDTGLSRQLTIPSTPEQNGVAERANRSISEAAQTMLYESGLPTVFWAEAVAKYVYVKNRSPHSALGGKVPFREWTGKPAHVHHLRVFGCRAWHTANTEQRKKLQPRGLPMIFLGYDLESKAYRLWDPVRARLTLSRSVTFFEDKFPAPDRRGPEVEVHAREENPVDNVDPAEQRGPVVEDVPKELRFEAPGPAWAAPVGKRDRRAPGRFEPEAFAAPIPTRRTAAMAHHKSHEWAQGAIDEFESLRDDYSVFTIMKRDELPAGAKVLGSKFVYRTKRNKDGRPTSYKAQLVARGFTQRPGIDFKKTFAPTAKFVSIRTLIALAVARGYHIIQADIDKAYLHGELEEELYMRVPEGIRLPDNVCLKLHRSIYGLKQAGRVWNETIHKTLVNLGYNRLRSEECVYRRTLGKDNYYIAVYVDDLLFIGPDLSEIDRVLNELDRLYGVKRLGNAEYILGVQLIRQADRIALSQRQYLLDVLARFGMADANKSTQYRSSIGLLMYAVVATWPDLAYPVSYLARFTNKAGSDHWAAVLKILRYIKGTLELGIVYKAKRDLLVGYVGYSDSDWGSCINTSRSTMGHVFKLADGPISWSSRIQSRVATSSTEAQYIGLTHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LPD3</accession>
    <name>A0A2X0LPD3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C011g06533 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C011g06533</name>
        <name evidence="1" type="ORF">BQ5605_C011G06533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LPD3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY12520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="100" mass="10657" checksum="077C3F93D46E6E1A" modified="2018-09-12" version="1">MMKDHSCLRTLLSMGMFGAGDLMVRPTGHVHGRPGLDLTSPAWMLLLPSLGYPPLFKPTGPHGLPDSPCGASSPLLCTVLPSQRAGLLLSTHSRPLPFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LPS1</accession>
    <name>A0A2X0LPS1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C011g06656 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C011g06656</name>
        <name evidence="1" type="ORF">BQ5605_C011G06656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LPS1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY12919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="90" mass="10352" checksum="102AE69D2DFD3908" modified="2018-09-12" version="1">MTPTSRRHTSSTCQNNRREADPYSLNFVAAISRYVNTCRGTSAHPHFLKAFKHTDQSYLHARMAQSQELEAESINDWIAEQVDNISYFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LSC8</accession>
    <name>A0A2X0LSC8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="10">1.3.1.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">BQ5605_C012g06935</name>
        <name evidence="19" type="ORF">BQ5605_C012G06935</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>5,6-dihydrouridine(16) in tRNA + NAD(+) = uridine(16) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53380"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:53382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5,6-dihydrouridine(16) in tRNA + NADP(+) = uridine(16) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53376"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:53378"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5,6-dihydrouridine(17) in tRNA + NAD(+) = uridine(17) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53372"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:53374"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>5,6-dihydrouridine(17) in tRNA + NADP(+) = uridine(17) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53368"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:53370"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Dus family. Dus1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.88" evidence="10"/>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LSC8"/>
    <dbReference type="STRING" id="796604.A0A2X0LSC8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF5">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(16_17) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="18">
        <location>
            <begin position="35"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="478"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="559"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="494"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="559"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="SGY16639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="602" mass="66535" checksum="1E73BE1D2400B386" modified="2018-09-12" version="1">MVCTAAELPTPPATSHDKLSGHEWWQSIHQPKYVVAPMVDQSELAWRILSRLHGANLAYTPMFHAALFSSNPKYEQEQFDSSPESIEGVAPYDRPLIVQFCANDKDKWLAAAKKVVGRCDAVDLNLGCPQGIAKKGHYGAFLMEEWDLIKSMISHLHEHLAIPVIAKLRVFPTLDKTLDYASLVYLSGAQLVTVHGRTREAKGRLAGFASWPKIRSVVDLLSPRVPVLANGGVPSAEEVEPCLAETGAKGIMSAEGNLYNPMIFSPVNAKAGRDYFAQLPQEMRLAISRCDEQFEAGVEWDRDMAAYAPSTWLAAQYLAIVSTIPHTKTSISAIKAHLFKLFRPVWAVERHLDMRELLGRAGGRRSLDYQAKLTEYQEIVNEFVRRFKVSPSCCGPTSQILLILTHTLLFQADLVEGHLPPNSFRPLTHAEVQATYGGVVPYSHAQPYLRVTKPEEDQVVAGTATSAENENKLVIQVETNGKRAASPSSLDETTEAKRSKRTDESTLDAFVIPPVIKDKTTPCINPTKDSSPCINIAANKCSHSACSACCASIRKEELSRGGCTHHEEKERKDAEKRQLKKDRVKDRKAKRAGAKGDTAFSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LSF5</accession>
    <name>A0A2X0LSF5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="5">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C012g06965</name>
        <name evidence="9" type="ORF">BQ5605_C012G06965</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="5"/>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LSF5"/>
    <dbReference type="STRING" id="796604.A0A2X0LSF5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07130">
        <property type="entry name" value="ALDH_F7_AASADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000018">
        <property type="entry name" value="Alpha-aminoadipic semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044638">
        <property type="entry name" value="ALDH7A1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43521">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43521:SF1">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="68"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY16724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="549" mass="58308" checksum="5A7EDC896F17D6B6" modified="2018-09-12" version="1">MIHLTRRRLVVALSPSSSLRTGGGQSYSASRTLSSAASSALSRLGLSSSSPNAGVYDGTSFQASGPLIKSINPSTGETIAQVIQASPEDTERVISSARKAYLSWRNVSAPNRGLLLREIAQTLRHHKDDLGLLVSLEMGKIYSEGKGEVQEIIDVADYAVGLSRSIGGSVVPSEREKHFITEVSNPLGVVGCITAFNFPVAVAGWNLALSLITGNAMVWKPSPSTPLTAIAMTKLMSKVFEARGHSGALASLVCGGAQVGEKLVNDKRVDLISFTGSEARGREVSMAVAGRFGKSILELGGNNAAIVLPDANIPLALRSILFAALGTAGQRCTTTRRLFLHSSIADSFIEQLRKAYISTSNRIGDPLDDSSLVGPLHGQDGVQKFKAAIEDAKKEGGEIIVGGRTKEMRGEFKGGNWVEPTIVRFKDATKAEVMKRETFAPILYISTFDTLEEAIELNNAVEQGLSSTLFTKDMSSAFQWIGPAGSDTGIVNVNGSTSGAEIGAPFGGNKSTGWGRESGGDAWKQYCRWSSCTLNWSDEVALAQGVKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LV05</accession>
    <name>A0A2X0LV05_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C013g07290 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C013g07290</name>
        <name evidence="2" type="ORF">BQ5605_C013G07290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LV05"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY15219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="89" mass="10322" checksum="18E630EF6EA96008" modified="2018-09-12" version="1">MEPQAQRSVRSMPSLVSRLQRTAERWELPFLSFYSGALTVLIISGVAHLSRAYLDLRDMRAQVSLTRSLGETLRDFNRKQQILWEGKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LV73</accession>
    <name>A0A2X0LV73_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C013g07360 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C013g07360</name>
        <name evidence="2" type="ORF">BQ5605_C013G07360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LV73"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="825"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="828"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY15410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="869" mass="95481" checksum="3AC1A738428C9F68" modified="2018-09-12" version="1">MYSQSPHRATSDRAGTIIGYIGYPAQAHPYLAYPLSPAERSDTGEGHHGLQLKTNKADSYAPAHTHSGQSLLPFSALRGVSCSLTQDHRLPTAERSTWTQPSSSSSHSVSSSAWASSQSSQYTFNSIHDPAQSYMSASVSPSGHITSELVAGFDQASTTERSPSQRYLGLGSLPVVDHGPTVQPLRSDKRLSFHYPLASTRLGSGTYSGAESATFSPPSSLASARRRNVAIGTDTSTFASSGSSPREEFLSPAVDDVSFIYPSPNIGSPTEELPNPSPSGSETQAPTVAEPKPAVAEDPVGKLADNLELLSFLKTHRVESPQVVLPFLLASSAQSVSISGASHASTLNDDPESQSPPAEWKEANTSKTQRVRDELWECAKCHKELGRLLLRNPMSQPPIPFLHTFLCSDCCPPEEEEDAAENPAAVSSSSDLAVSYESGFSGLLDKESNIPIPTRTTPRVQASGKRRRLTGSLSTCDVCMHFIATSSAQDEDSLRPTSAPLVERICKHCHAKYRRCTDCGGRPDKRLGVGRWRLKELFPDGTRRCIIPHRPLRSLTETTCDVWRVSELPSDEVPAYLTEIQKVMSLAMFATMAIPDTMECESPMCIDFRSAAVLASEAFRLLTPLITTDVEESLGIRRYITLRWHNPLLPRGERLAVPPDPQSQDPDVIALQKPPNLVREKYTLFAFNYIELELKTGSIAVALSAPRGMGHSYHAQTHSIQCAIRRAQHDLAKTNRERMAEGLDAYPEINELWLIIRSQNTTLTRVLHRDKCQRGMIPLDEYLVKHASLTDPKKFPPHRSILLPWEFLKRYRFYARRLSGKDDLTKIPGRRKTAGGNKARRGRLPIDADNGSNVTIPKGKDDESDDEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LVA0</accession>
    <name>A0A2X0LVA0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C013g07171 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C013g07171</name>
        <name evidence="4" type="ORF">BQ5605_C013G07171</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY14933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LVA0"/>
    <dbReference type="STRING" id="796604.A0A2X0LVA0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053229">
        <property type="entry name" value="NADH-Q_oxidrdct_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024549">
        <property type="entry name" value="NADH-UbQ_OxRdtase_su21_C_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019721">
        <property type="entry name" value="NADH-UbQ_OxRdtase_su21_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34062:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 21KDA SUBUNIT N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34062">
        <property type="entry name" value="OXIDOREDUCTASE 21 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10785">
        <property type="entry name" value="NADH-u_ox-rdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12853">
        <property type="entry name" value="NADH_u_ox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 21kDa subunit N-terminal" evidence="2">
        <location>
            <begin position="12"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 21kDa subunit C-terminal fungi" evidence="3">
        <location>
            <begin position="107"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY14933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="171" mass="19145" checksum="CFF5DBD8E2CEF416" modified="2018-09-12" version="1">MAPIARDNQLKTPYTVLDTDPHATRVIKYMRPADYAAWAGMTAAAPLAFYGLELADPTKMTRAGLRPGLRLTAFLGFTGGFLLAYQTSSLRLWGWKENLAEEKAIEQEMTALAKAGKPLYGEQTLSPYIQGVAHRNSLWSQLKFGVMPWFNFVRHPHHGVDVSKYETSKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LWW2</accession>
    <name>A0A2X0LWW2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C018g08743 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C018g08743</name>
        <name evidence="1" type="ORF">BQ5605_C018G08743</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY26531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LWW2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY26531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="305" mass="33685" checksum="C8C2AEE02054DC56" modified="2018-09-12" version="1">METYLGVDIEPLIVKALEVLPPLLIEEQYTYLFKDPREQRGLKKGLVVLDSKEWKSVENAVRSLAALGLNNDAAPPMTRPMLKQRNTSCSTSFNWFRVATLNGTSILSQAQIIRLPSLLRHESRQLALDLNSLIQHRRAHQCAHLRAVLLKGRHGATTSTSQVSDPTSKAKLSEHGEMLSSVLRGLVHSMGAARLEAVSGVARSIHWTGQGTFSRFSTANETENIGYIEDRRKEVRMQLRARQYTVFAKIPMFGSIDGNVTSATPLKIGSLVCFGLKRSITPVSCDASNIGEEQLSIGLGSYISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LXG0</accession>
    <name>A0A2X0LXG0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g00983 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g00983</name>
        <name evidence="2" type="ORF">BQ5605_C002G00983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY28906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LXG0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008999">
        <property type="term" value="F:protein-N-terminal-alanine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051908">
        <property type="entry name" value="Ribosomal_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43441:SF5">
        <property type="entry name" value="FAMILY ACETYLTRANSFERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43441">
        <property type="entry name" value="RIBOSOMAL-PROTEIN-SERINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="70"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY28906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="277" mass="31574" checksum="18515666EFACEB4D" modified="2018-09-12" version="1">MPNLNLYVPPQPLETKTYHLQTPKEEYDLNFVLPVPEFLETEDGVRLVPLVPSLHAQILFPLFSSHPSMMRYLPYTYTTLESFLTFLEERRRDPGTLLWVVYDLSLILDGKEGGAEVVVDKENRERIAGMVGLLKCNDENRWGEVGHLAILPPFHRSPINTHSCSLLIRYLFDTVLFRRVCWFAHADNTPSVNAALRLGLKKEALLKWERCLGKGKDGKKLEGVLEGLREGEEKAGRWGGDEIRTFLDWGGMIGGPEVQRLLMVCSVGRSRRGRWGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LXG1</accession>
    <name>A0A2X0LXG1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C015g07757 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C015g07757</name>
        <name evidence="1" type="ORF">BQ5605_C015G07757</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LXG1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY17349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="223" mass="25107" checksum="42A4A70D28629BD3" modified="2018-09-12" version="1">MYCPCQSRNSLTVFAFYSAKGAPTLCNTPRRSAHRSDNDKITGPKYVGLTLDTLQTKSAQAHGPYTLRSWTRVDPWAMIVKQSRIQKMLRWLINESKNSAHSAVSFDGDLYDSDFDATQVFRQLAFRVPKEKVARIAAALLEIDMDVVSEMIKKSKDTNRYKAATEAEKHINRILAELQSAGDKIHGTTAQMLGMRNEIRGYVNAFGILGRIKDKFLDQADTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LXP7</accession>
    <name>A0A2X0LXP7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C015g07857 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C015g07857</name>
        <name evidence="2" type="ORF">BQ5605_C015G07857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LXP7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY17688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="279" mass="30551" checksum="DB36EB66C88D144D" modified="2018-09-12" version="1">MNMTIAELLAFDVAPADASLHIELTKDKHTQYSTLSSTRGPTSSCSTQGRPVESSDPTRGEAGVGVSNTEEGRSTAHSCVLKGLKNAYIEDGRIQEKLPERDKQYGALAQRYPHFGSFDGAVTAATPLEIGSRICFGLKCGMHSLSCDQTVYGEEALSIQSDNKPLQPRYARLVGSTLKCRPRAHMPSKDLPPFGACPACEMPPAEPLQAAQMPPRKQGAQVQQKGSLTTKQRASQQSKEGLFEAWSHAQHQPKRRAPQATFDKPPRARKRSERVFEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LXW0</accession>
    <name>A0A2X0LXW0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C015g07937 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C015g07937</name>
        <name evidence="2" type="ORF">BQ5605_C015G07937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LXW0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016116425" evidence="1">
        <location>
            <begin position="24"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY17961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="103" mass="11254" checksum="765D0FA9C13B7293" modified="2018-09-12" version="1">MWKPRFGWCLLVFVLSSLGRTRSQLVLLVLLPHSIDYITCGLSLCYSLAACSACSAECRRFAHLRSLAGFADESDARRPCLADAALVHSEAHLIVHAPPSCIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LYA5</accession>
    <name>A0A2X0LYA5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C017g08295 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C017g08295</name>
        <name evidence="1" type="ORF">BQ5605_C017G08295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY19754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LYA5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY19754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="148" mass="16778" checksum="9D7E5E5230FCDAA0" modified="2018-09-12" version="1">MPSPEAAARNRSTQRRANWFIKATAPAAGSLNVARQVQRARSFSIFLPPALHTLPIAPHPIATLSLRHPKRSSYEFENSLQSVLFECQLSSCSFTVSCGRIDFVRLRIRVHGTLNFHRANHAKKKKRFRELRLIIRGRSSTARFGTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LYE5</accession>
    <name>A0A2X0LYE5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C002g01283 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C002g01283</name>
        <name evidence="3" type="ORF">BQ5605_C002G01283</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY31940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LYE5"/>
    <dbReference type="STRING" id="796604.A0A2X0LYE5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF294">
        <property type="entry name" value="RETICULON-4-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="41"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY31940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="394" mass="42205" checksum="E541EF306A6FE88F" modified="2018-09-12" version="1">MAAMKEPSSTQAPHCSASPSSSSTAAGPSFTAWTHATPPFGSTLRKHTFKPPTLSPTQLLIEVDRAAVNPVDVQIANSSVFKLAALSYPKGIGEDYAGIVIAQGREVIEFAVGDTVLGFYLTALGKPWEGALSQVRIVEASSAVIKYSPSAKLSPTEAASFPLVFQTAVTALTPPYTPKLDSFRPSIVVLGGSSGVGIYAIQYAKSELGAPKIVATCSGKNAEFVRSLGANHVIDYISESILEGLLKHRPAEGYTTILDCVGGTALLPHLGQLLTHADGSSGHPGGGYITIVGDATDSERIGGATVYWYSPRMVWRSLWSWYGLSSKWRYSCISLKASKDKLHKGVELIQDKGIKVVVDSEYEFDDVEKAFKKLRTRRARGKIVIKVKANSDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZ45</accession>
    <name>A0A2X0LZ45_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C016g08047 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">BQ5605_C016g08054 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C016g08054</name>
        <name evidence="1" type="synonym">BQ5605_C016g08047</name>
        <name evidence="1" type="ORF">BQ5605_C016G08047</name>
        <name evidence="2" type="ORF">BQ5605_C016G08054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY20434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY20449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LZ45"/>
    <dbReference type="STRING" id="796604.A0A2X0LZ45"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY20434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY20449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="188" mass="20831" checksum="2DA4B541FE849CE7" modified="2018-09-12" version="1">MIIDRTSCNFIKVSEHSRRPVTNPTKEILTSIPSPFTLKVHSIALEGLEATDIHVNSLIAADEKAEAELRWKLDLHRGHPSPALVSARKEFGLLSDLLPRQHSVNDRTNIGIARLAGLEADLNMTGTYDYNILLSSVYMTFEIFSSPPTTCARSPDRCGMYPGSRRRHFRHSGPGSGCLGIPSESFRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZL5</accession>
    <name>A0A2X0LZL5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C016g08234 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C016g08234</name>
        <name evidence="7" type="ORF">BQ5605_C016G08234</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY21416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LZL5"/>
    <dbReference type="STRING" id="796604.A0A2X0LZL5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF291">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="267"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="593"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="629"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="682"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="729"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="740"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="760"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="800"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="810"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY21416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="838" mass="93062" checksum="C02F4002E828C8CF" modified="2018-09-12" version="1">MPRVKRSASALVNDDDNASRSFSSNSTSRKGAASAPIACPTGSSQRRASNRTTSPYKRLTRKNPAQDDDHHTTETSPRRSTRRRTTLAEHSQGDSDRSSSLEVLEPAAIAATTKEKGKPTLSASSSTTLEQDDLRTNSVTHNDDSITTDITEPEPELEPAKSEVIDAELRRKNKASSQTSTTSDRDQDDMISKAEVRLRDKIKANNTFVDQQDELLRQLTQFTDSLRATAQCGICLQTMRAPHALECGHVFCRQCLINCFFSANNGDDDDDDDEEEEADQDNEENLSRSGSNSHTDSDYSNSELEGNDASLSFWEADQPPTPPEGMETIRLTVGNRSFQMNRPEPGYRPPQATAEDSASRFVELGSDDDDDDEQEFEVIGAAREGIARVERIARVERIARVERIARVERIEPAVSLRHRSPRENDSTSPATSPGRAPAAGARIEDRIIIADEEVHQAGPVPPMAHPPSHPSNVICPSCRTKVDTAPKRIFVLTDLVHRIRQAEQEGLIGDLDESAPPKSDKADEMEVTIDEHDKSWGGLFMELDVGGNTKGRTRVARDRDDGVRRCPECSWEIIEATGECAHCQRVYELSSDEDFRRRHHDGGAESDDEGSDISVRSMPRHGVRRPREEEEEEQPNSEDEAFIDDAPIRKRRRTDGEASSRRRRRKSEVASSDEESRLEFTSDAALSLSSGSDGDSDSESAVSTSSSRHSDSTQKSSEASFPDEGRDATKRRRKARREVRRAEEEKERRKGRGKGKELSEVEDEDESVIIEESHESPRKAAAKAAIRRAEEKGSGEEVTETSAKASTSARVDKGSKEKSARKGWRKLPKITHSDDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M049</accession>
    <name>A0A2X0M049_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C016g08172 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C016g08172</name>
        <name evidence="1" type="ORF">BQ5605_C016G08172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY20941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M049"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY20941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="274" mass="32089" checksum="4BAB95B37BD441D4" modified="2018-09-12" version="1">MYDLPYAAKCSIINIYCYTKILYYSRFLPAPKSVVKEIEEAAMLAIHGRASDGTQRRPKVSRSRLCTPLDHGGFGLIDLPWRLAIVHAKWVFQLRAPDGCFTRHLFDIRIRLQAPNEPTPFTLSRPAPNQHRCPWVWIWWVYFCHPPPKWDHAVRKTTKLLPARWVRYFEAWALVTTLNPPELSKSQNLEQWATHVLYFPAGHGIQLSVNPTLFRGPDGEVMTPSSFVNASKRHQVFIFPLIFPKGHQKVFDLPEQRWNAWWKALRKVRRVHLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M076</accession>
    <name>A0A2X0M076_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C016g08202 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C016g08202</name>
        <name evidence="8" type="ORF">BQ5605_C016G08202</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY21147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M076"/>
    <dbReference type="STRING" id="796604.A0A2X0M076"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14137">
        <property type="entry name" value="STKc_GSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050591">
        <property type="entry name" value="GSK-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039192">
        <property type="entry name" value="STKc_GSK3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057">
        <property type="entry name" value="GLYCOGEN SYNTHASE KINASE-3 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057:SF0">
        <property type="entry name" value="PROTEIN KINASE SHAGGY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="127"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY21147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="511" mass="58014" checksum="0DDC5A1B717DA21D" modified="2018-09-12" version="1">MFCTVFPNLRIHHFHGYGSPQSLLSAGRLCPRPSGDSSLDLLSEMQTAARSIDADDVSGAGKAGSRSHLTGTKFRDYTFRTYRHERTFGAFTGDCDSWSEECMVDPTRVYTIEATSVQTGQKTRLQYTDCKISGHGSFGVVVAARLIDGDTGRVALKRTKQDRRFKVGYWLYRSSYADSNRELQIMKITRHPNIIRLLYWYYEPSGKPEEVYLNLVLDYEPETIFRTYRIWTKQQLRFPEFLIKVHMFQLCRAVSYLHSMGICHRDLKPHNILVDPRTCKTTLIDFGSAKVLREGEANVSYTCSRYYRAAELIFGATMYTHQLGSTSYPDTIDMWSIGCIFAELLQGSVFFPGSSGVDQLVEIIKVLGTPSPDQIKAMVPNYHDRGLPHIKPTPFSKLLPRASPEAIDLLQNLIVFDPSQRLSAAELLAHAFFDEIKHPGPSGTGPVLPGGERMPPMFNFSHHELSIRPDLVNRIIPSYARREIYIQHGIDLSKSWQPIDLRTVRVDDIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M0C7</accession>
    <name>A0A2X0M0C7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C003g01945 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C003g01945</name>
        <name evidence="4" type="ORF">BQ5605_C003G01945</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY38033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M0C7"/>
    <dbReference type="STRING" id="796604.A0A2X0M0C7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="256"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="282"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="302"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY38033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="379" mass="40122" checksum="09CDB50C290DD85E" modified="2018-09-12" version="1">MSSSYGTRRSLALQQPLHNNNAAAAAALAATNPSPRTIPSGRRSSSNVATAHELATSYGRNGPLASSPLLSSSAGKQKRPSTFKAARRTSTSQSLRPQAADLGVARSLPTQLSGAQAKGAGSKAPAMLSKRASQFSVSVFDEDEDDGEIKPGAKREKGTTVYQCEICSKMYKHAACLQKHRWEHTEQWQEASKLLLSKHQQVQLFEAAAILQVASAGASLPQDKAYWPAAMSPPSAGLLGSQAFSLQSPRMLQSLSLHSDDTPYGSSSQPVAPSFSVASSSDVEDDDEDDDLDLDEKVKLDEGDDEDDDGDDVSDIMDEVDGGMFDLDLGGGMDGIEAEASPAPLALRKERGPILEGEGELSSTRIGATTMMTLSSGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M111</accession>
    <name>A0A2X0M111_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C126g13332 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C126g13332</name>
        <name evidence="2" type="ORF">BQ5605_C126G13332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000026">
        <property type="protein sequence ID" value="SGY27604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M111"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY27604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="444" mass="47241" checksum="A1699C31CF07DA7E" modified="2018-09-12" version="1">MQTGDPGSAPGARAPPPPASAPTSLPIAGTKETQATQVAGRTATYAAATNSSVVSNETPAQQQDRLARLQALPGILAAIQAVPGNRADRFVQAIFATPDFPSTVATALKFSALNATRNIINPFANALEVSLSHKSTGKASATDKGELVACVRTLLSPNTPICFDTGVPLSGDLEAFMPRITGLQHSSTFRTGVLHHRITVGFVSAEARDAALASAPMLVWNSANARFAKAHPFHRNMLEMRINVGVVRPPSKEQIVAAFQSIVQQLSTKGHSCQLVQVLRVIHVDTAKAYAHTVGDFSAFIHFDDASLFQHPTTTLKEILPSRMDLPTRGLDVTAVRHDYEKEAPCARCHFAGHVERCPLMQAANRKEAEDLARHAVMRGAGMVGGGEQTGVGRAATTTTNNIRPTANNNNTSEVVAPSRALGTDQLESRNRFCGARGRRRTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M148</accession>
    <name>A0A2X0M148_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C018g08607 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C018g08607</name>
        <name evidence="9" type="ORF">BQ5605_C018G08607</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY25373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M148"/>
    <dbReference type="STRING" id="796604.A0A2X0M148"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="126"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="160"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="264"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="843"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="37"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="317"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="355"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="843"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="880"/>
            <end position="897"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY25373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1040" mass="109414" checksum="9C8806936915F8BB" modified="2018-09-12" version="1">MSSTSASYMGRSEGGRSSLSTTNTYGAVGAGAPPPSSTLSATQLQALNQQHYYNNNGSPNGDYTSSHHAMSVLDDDLDEADDEHSNSPAGQGGSTAGGNRSGTPTQQHRMTGSQATDPTAPRSGRACLACRKLKTRCDGAEDPPCKRCRAGNHECVFVESKRGKRPTKPPGGTPNTKASNLPNTSASDNSAGNSQHALGSNSGVGGSADHSTTTTSNGNGSGHDAALAEKFRSVEKNLSLFLQSMNSGGAPDPSALQQLKSTLADGIDTSRNGKSINNGARATSTTMESPTAAGDDSHAGGSASIPPAKRPRHASGNYPQSTSSTDSPFTTNNMSLSPNSVLNSARIPTAPLSHTPASTDSGLLPSASRTPGSAGGGSSLSMLADASLAAQLDGRNKLTGLDPGFNLSRMTEAIQGDGSEGGDEARTPALLSKGIITPETAVDMFRIFFDFCYIHLPLLDPAQNSATSVCARSPFLFTAICAVASRFNPDPTLHVKCYDEAHACFVDTVANGERSIESVQALMILTVWTSAPKKEAEDRPQRAWLYFGMAVRMGLELGLFRPPPFVDHHLSTSRNASQANPWANLKDVSEEEQRDAINRERTWLMGFVIDRNMSAVMGRPYQIHEAKPLLIPLHTMSLPFDLGVIAHQELQMIIGQVMDTFRDRIYGLSSASDEMPSATVMKIFNNRMDDWRQRWCPVAGEPIANNLLFYFFSSKLFLNTIPLHTMLRNGEVADDPECVSTTITAAKSVLDLAHKYAELGVLLHCPDVNFLLILYGAVFLIKVKVSNTRFSQLVDADELQQLLVQAIYDCQAATCSPRHAASTACTMLRALLASFKAMLQAQQNPANPHGMSRQQTNQNEAGGRLPHSGLAADGSSDPFGANGSSSGPPGSALGLHGTLAGAPMSPSASYPFMSTPFAQRNHDNRSFFGSGAVATGGSGTMSGTHTPAGHQTYGTGGGAAGAGSAGSAGASNTGFNPMDPLDSFLNDTNFFSSVLVSQGADGFFTWPEGLDAAGGLDINFDSNTFNPSHLDAEMNGPLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M1N5</accession>
    <name>A0A2X0M1N5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C002g01101 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C002g01101</name>
        <name evidence="1" type="ORF">BQ5605_C002G01101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY29955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M1N5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY29955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="50" mass="5841" checksum="E3CCBF9D7E73844A" modified="2018-09-12" version="1">MVEETTLRCGRHAKPVVWETESHVPRCFDGKWNLGEQLLMTSRHVVCLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M1P5</accession>
    <name>A0A2X0M1P5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Calcium-channel protein CCH1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">BQ5605_C002g01112</name>
        <name evidence="20" type="ORF">BQ5605_C002G01112</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY30066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0M1P5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000093">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF7">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="431"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="468"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="674"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="713"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="737"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="867"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="952"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="983"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1068"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1147"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1377"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1413"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1457"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1631"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1744"/>
            <end position="1765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1777"/>
            <end position="1794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1837"/>
            <end position="1856"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1922"/>
            <end position="1944"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="19">
        <location>
            <begin position="1967"/>
            <end position="2002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="115"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="235"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="359"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="512"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="2203"/>
            <end position="2252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="246"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="359"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="378"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="559"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="2212"/>
            <end position="2221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00061395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00067459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="SGY30066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2252" mass="251999" checksum="9C0EDE2627F18F2B" modified="2018-09-12" version="1">MSSLLVPDDDRRHILHEGRHDERDTTSTSSAGHVGQREQRRPPSMASLSPFGDASGSSDRASSFIDAYFDDTRSSTDLEEPYLVAQAASAQRGGAKANQPSPTSVSRPTLAVDHTAATPAQQPTASTSTSIQSVSTSLAEHDASMSRSSSSGSSSAASITTPIKRVQVSAALPTSDSNLDAMQRGWHMHVSPVGPRFNNPFASDSTDPFDPSELFKNATQPLNIARVRAANGNYQTTSSTSLDNLDETRPFRYDSDEEGRRSQVKTPSKRLSGAAAEDRWHGLGLGSGVGDDEEVGLRPASTTVEGNVAAAVSEGSHGRLHPRGKRKTKSSFRNSFTQGLQRMSDRVVGFSDAQDEFIDDSHRQLSDRDHRHQKLGSEDGEEDPTEEETEESRYETAFKKLRGKSLGLFGESHWLRRACAKLLVSKFTEPVIFLLILASVVVLTIQTAPDVYAHPRLQTGYFHDWTDYALLAIFCAFTAEMFMRIIVTGLIVNPPAPVSFSVVIPTPTSPEIMRSQAVTTGSSRRDRSPSRDPYAPLPSPSGKRDSSLVLHAVRQLKHSPVSTRASRSPRSASPIQRHFTVRRPSHSPSTVSGDARSLELPRDASLPVPPRPDASLDLDAKEVPSPPEQAHPTRAAHSSTTSTLLSRDFKAPFSDSFRRQRDIMYSRAYLRHSWNRLDAVAVLSFWIAFGLSIGGVKTTNGVELFRAMSVLRSMRLLGVTTGTSTILHSLKRASPQLVKVGFFVAFAMILLSIVGIQSFGASYARHCRWIDPAGVLESVDFPEQACGGYYNMTTGIIERVILSSGAFSPEQPKGFTCPPPSVCVMGESPENGALSFDNIFTSLYQMGIIASANTWTGVMYRMADADAFPATIFFIVGLIVLNYWLWNLFVAVITSTFAEIREESEQSAFSATADPSAKPAASGGVPHVQGGGQVKGFNRSARWVAVVYRKTYLIWVFLALFSIVCQAATTYDMPLNRKVVLGTIERYVTLAFGVEIVLRFYATFPDWRSFFHHLENLIDLGLVIATAIIQIPVIRTSEAYPWLTAFQIARFYRVIMAIPRMNRLLRRVLGTFTGLLNMTLFLLLMTGFASLIASQLFRGVPDPDDSDTTPLIFSTSYNSYLAVYQILSSENWTDVANNVLSAQQNIFATAVTALFMSCWMFFGFFVLINMFIAVINENFSLPEEEKRKLQIEAFEKRLDVPVTRKRWWHRFHVYKFDESAQTSPKGASLHGTADVRDFASENGATPDKKVHTRGQSLTETLMGSARRAFGMNRHSGASTDALAMEDLHPMDDTIVYQGTLFRLTSQAERDAEVRRAQARERRARLASYIGEHPSYDKSLWLLSQDNPLRRMCQALVDPAHGGDRLFGRAPSQVLRFLFQWLIFITIVGSVVIAAIATPIYRRNYYIEVGDVRWPWFVLAECTLGFIFVIEFLVKVFADGFLFGPNAYLRSTHNDLDFFVLITLLVNIVIALLAGPGLNRFTRSLKAFRALRLINLWPKLRETFYNVLIVGFSRILDASLLAILYLIPFAVWAQNIFGGLLFSCNDSSVLFKAQCGGEFASAAVSDWNYLQPRVWDNPSGDPSVWNFDNFSSSLLILFEIISLEGWVDVMLSVMQITGPDRQPQTNAYQWSALFFVFFNLVGAVVILTLFVSTVIENFEIRSGTALLTTDQKRWLNLRRLLARQRPSKRPKRRPISAFRGWCFDRATQKHGWWSRSMTALYCANIIVLCTQATTNTDDGFDVRNYIFLGFTLIYGIDIFVRMFGLGWSSYIMNGWNQYDILVVAGTFATTIPIMLSSQSQVAHQLQKLFLVLVAFKLVQRNNSLNQLFKTAVASLKALLNIFGLWLVLFIVWAIFYIEIFGLTRWNFNETHNANYSTFAKALVLLALQSTGEGWNAFMHDYMVEWPRCTTSTNYLDSDCGSTAWALVLFISWNVLSMYLMANLILGTVIENFSHVYQSWGNVNYPNREEMRGFKKAWGEIDTERTGFIRRREIVPFLRKLTGIFEVRIYRAEWTIQVLRNAASVSSTMSRKPSLSDPFSATSSDFGFPRLERDASTIDAMRLAHAIRAIDGNEVRQRRYLWNRLYHEAMIEAEKDDRGISFGNMLELLAHYRMIDDDTALQVDELLDRRQQQDRVMERVNSDVVRGVLQRLTWRRRFLAHRAAQKSGGIVPPKIRVQVPPTEPPSTPMAQTRQTLTINTTNLATTSLDEHELSSASKWSSTGRVGEPSSRRKGLRRRGTSSDDGSAGGSENEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M216</accession>
    <name>A0A2X0M216_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C001g00023 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C001g00023</name>
        <name evidence="8" type="ORF">BQ5605_C001G00023</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY43431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M216"/>
    <dbReference type="STRING" id="796604.A0A2X0M216"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF19">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01812)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="71"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY43431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="562" mass="62566" checksum="C5DEC2C4B9516138" modified="2018-09-12" version="1">MAPLNVVTNASSVDDEKMVLEHDEVGSPVGVPFSKADEKRLIRKIDWKIVPFLSPRPGHRDDSTRSEFYFVSPTLCLLYLMSFLDRVNIGQARLSGLEKELKMSGSQYSIALLVFFVSYVVFETPAVIFVRRLRPSRLLPTAMLIWAIVMTLMGVVTSFTGLVVARFFLGMAEAPLFPAACFYLTSWYKRKEQSSKVYISMFTGFRRTDASLDLSVRISIFFSAATLAGAFGGLIAHGLAQMDGLGGYAGWRWIFIIEGIITFAVACAAPFVMTDFPEEAKFLSVEEQQEVLRRLKADRGPTLQTEFSWAQVRVAFKDWKTYCFTLIYIGVAEPFYSLSLFTPTIIAALGTYSKSQASLLSTPPFFLAFLTTIFSALYSDRLGHRGFFNVFWLSIVVIGFILLLVLNPVHSPKVAYFSLFLCVGGLCPCIANSIAWIGNNFSNRTKRSAAMGLFFSVGNSGGIVSSMVYFKQDAPRFIRGQSVGLGFTLMALVLSLGLTLHLGSENRAKDAKYGPVQEGDEEFEQLPLELQRARTKAWRLEGVAPQQLSDLAENHPAFRYVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M4V3</accession>
    <name>A0A2X0M4V3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-chaperonin molecular chaperone ATPase</fullName>
            <ecNumber evidence="2">3.6.4.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C001g00953</name>
        <name evidence="9" type="ORF">BQ5605_C001G00953</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.10" evidence="2"/>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY51035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M4V3"/>
    <dbReference type="STRING" id="796604.A0A2X0M4V3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10241">
        <property type="entry name" value="ASKHA_NBD_HSP70_BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000014">
        <property type="entry name" value="Chaperone protein DnaK HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000005">
        <property type="entry name" value="Heat shock protein ssb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042050">
        <property type="entry name" value="BIP_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY51035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="677" mass="73790" checksum="7DA5E82D5EFD2C8F" modified="2018-09-12" version="1">MPYIALEPWHHVHNLPSTMILHPILPPTRGASDAGSPWTDKLIFPLVPVFLAAVGIDLGTTYSCVGVQKNGRVEILTNDQGNRITPSYVAFAAGSGERLVGDAAKNQAPSNPTNTIFDIKRLIGRRFSDKAVKEDIKHYPFTVKPGKHDQPVVEVSVGNERKTFTTEEISAMILGKMKETAEAYLGKKVTHAVVTVPAYFNDAQRQATKDAGTIAGLNVLRVVNEPTAAAIAYGLDKTGGERNIIVYDLGGGTFDVSLLSIEDGVFEVLATAGDTHLGGEDFDNRVIDYIAKTWKRKHDGQDITKNLRTMGKLKREVEKAKRTLSSQMSTKLEIEAFFEGQDLSETLTRAKFEELNLDLFRKTMKPVEQVLKDAGFKKEQVDDIVLVGGSTRIPKVQELLKEYFNGKEPTKGINPDEAVAYGAAVQGGILSGEEGLGDVVLIDVCPLTLGIETTGGVFTKLIDRNTVIPTKKSQIFSTAVDNQPTVLIQVYEGERAMTRDNNHLGKFELTGLAPAPRGGPQIEVTFEIDASSILRVSAVDKATGKSESVTIENERGRLSQEEIDRMVAEAEQFAEADELVKKKIESRNALENFIYSVKGQLADTKDGLGAKLDKSDIKTLHAELKKSQDWLEANADASVEDLTEQLETLQGVVTPITSKIYGGAGGSDEPLSNHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M544</accession>
    <name>A0A2X0M544_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g02142 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C003g02142</name>
        <name evidence="1" type="ORF">BQ5605_C003G02142</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M544"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY39098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="159" mass="17965" checksum="0AD12C1D7782779C" modified="2018-09-12" version="1">MTRRLARIAAVRRIYSLEVRLHKLSLRQYLSWYFSPSTQHDRVHNHRTKLFNSNWTQLKHVLDLIIQLARDDGPDARGRINNWIANQTVGLSTGVASTANQIKPPLAIYISTLKSGARSAPPTLASARRSPGCWMARGLAQHGGWCGLQHVHLIEKKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M5D1</accession>
    <name>A0A2X0M5D1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endoplasmic reticulum transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C006g03909</name>
        <name evidence="7" type="ORF">BQ5605_C006G03909</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BCAP29/BCAP31 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY54775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M5D1"/>
    <dbReference type="STRING" id="796604.A0A2X0M5D1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008417">
        <property type="entry name" value="BAP29/BAP31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040463">
        <property type="entry name" value="BAP29/BAP31_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701">
        <property type="entry name" value="BCR-ASSOCIATED PROTEIN, BAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701:SF20">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05529">
        <property type="entry name" value="Bap31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="BAP29/BAP31 transmembrane" evidence="6">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY54775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="183" mass="20857" checksum="400398C164060FD9" modified="2018-09-12" version="1">MAIPNQIVFGLLLFEIATFIVLIVPLPFTWRRALFKAIAESQLVAKAQYALKITFIFVFLLFADAVNHMLKIQREGVLNKQLGQRSDLRGESDYRSRKFLSERNFYLHGFTLFLSLILSRTYSLVLDLIKAQEDLALLKKANAGGGLKGSVGAGDEQLRKEYEDLSKRYDELVKKSPVEKKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M766</accession>
    <name>A0A2X0M766_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C001g00599 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C001g00599</name>
        <name evidence="10" type="ORF">BQ5605_C001G00599</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY47995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M766"/>
    <dbReference type="STRING" id="796604.A0A2X0M766"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041653">
        <property type="entry name" value="Importin_rep_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18808">
        <property type="entry name" value="Importin_rep_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IPO4/5-like TPR repeats" evidence="9">
        <location>
            <begin position="184"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY47995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1189" mass="130574" checksum="7AA47327077EFE2B" modified="2018-09-12" version="1">MEPSPALIADLTETLDRLSSPTSSLRTTAEAHLHSELLCPSNTAQTLLALVHIATSLQGTSPRRVQALIILRRTALQSPTVLDLEARRQRDDHDHDQAPTHPALLGPRWSTLPLHTKDLIENRLLGVLGESDMRPGAERKALCDTIAEVYKLNQPGRSASSEISDTHHHSRINFIAFSHLLSGPWPQFASVLSQLFSSPSPSLRESCFRLYAECIDLLEQEPPTTASQGLLRGLQDPAIHTRLAALQAASKLLQVLEPPSKLQSYTELITGMLEILPALTVSAASDDRPLTTALLEMIELASIPRLASRVFKPHVTALTHFCTSIIQSPETYDENIRASALELLVSLAETAPTLIRTAGNFTPMIVEICLDLMKEREDDPEWLGKEVIKDIEEDDTIATIAEQSLDRFAQRLGKDVFGAVQGNLGKLLGKDKTWQVKSAGLSAIAAIAEGCRVQMQGNLEQIINAIVALTGDDHPRVHYAIIYALGQLCTDLEDQVQAEFGQQVLRVFVSNMLGQEPRLQAFAAAACVNFFRATEVVEPLKPFLPDVMRGLLHLLQTGSTFVQGNALEALTVVAAYMEEEFAPVSHLSEVIIKTVALILIAYFTTKYYTEIMPHLLRLLETEASPEIETLRAQALDCASNIAAAVDPSVFEPDATRLIKAMQNISKSLPEDDQVTRPYLLTAFCHLAATVGAEAFAPYIDETFPQLLKRAARDAQVTIGELGEPHPSEYNEEGEDDWESVLVDGKTVSIRTSAVDDKLEAVQNLISLVSTLGVTLPLPELQQVVQTTLPLLNFVWHIGIREAAAALIAVTVQSLALHPLNAEERTFICSNCSDALAPHLCSDTDAEFLATALSSIATVYTSFPRGTLRVDSRNLCIRAMEGQFVDLARREQERQHERGGEQEEDAEYLDEEVLEIEEGEKQVYYGINVVVKELMKQHDVRSLDVGTSTTSTTFPLAVFEPALKVIATPSGQRLNAAQFGLRLVCDMLDQLGERAVKTVQPYLNALAARLHDENPTIRRVSAYAVGIAVERAPSSLQPWAINLVDSLFTAIAVIDPSDLEQDPAVLAARDNAVSALSKIIRRSPPATIEPILERWVLTLPILVDEDEFEHVYPLLIDLLHTNHPSTTSPTVATHILNVLVQTLQQEILPPTLEESLCTELKNFVAKLPQGSEARVQAESISQDVRDKLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M8L7</accession>
    <name>A0A2X0M8L7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C001g00897 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C001g00897</name>
        <name evidence="1" type="ORF">BQ5605_C001G00897</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY50568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M8L7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY50568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="102" mass="11350" checksum="9CC241A608E17367" modified="2018-09-12" version="1">MATTRVLTSATVAPPRRVVSSLHPSVMPLRYLLLFPAGEYDFLPKIPLCGSTKLGHPSECSILLLFEFHPPVNLTGSHWLFVKTVLSSCPQFLFPLLCLRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M911</accession>
    <name>A0A2X0M911_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C004g02843 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C004g02843</name>
        <name evidence="4" type="ORF">BQ5605_C004G02843</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY68054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M911"/>
    <dbReference type="STRING" id="796604.A0A2X0M911"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051020">
        <property type="term" value="F:GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15473">
        <property type="entry name" value="Myo5p-like_CBD_DIL_ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037986">
        <property type="entry name" value="Myo5p-like_CBD_DIL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052072">
        <property type="entry name" value="Vascular_dev_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027:SF6">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN YPR089W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="239"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="272"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="3">
        <location>
            <begin position="525"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="429"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="837"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="982"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1048"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="445"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1057"/>
            <end position="1067"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY68054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1098" mass="119326" checksum="C6FEEA9C1E1E102A" modified="2018-09-12" version="1">MASTSVHQAESGTGAELDESSVVTSSTRGGSSRLVLPDSPPLPSSSSQFPPWSTSARSPRSTRMSPMASTSSVSSSTGDGVVESAASAAASAAARRWRHAAATNQSLYGQEDTAASTASTSILDVALLPLVPLPHHLAPYLTESSPLTPTEKRTLFTSCFLRAASANNHDTLEWLLSIPRDPTLSHAANAANHRRRFSAAGNIALESLAATTSLHLDETHNLPDDAPRKWVDIEAVDQGGNTALVLAAALGHSESVRTLVEGGASVAQGDNAGWTPLHWAVQNNDLAIAAYLLNHRASPNAHSKKGLTPRDLINRNEHGTAMMDVLDSADAMANERENDDSMLEEDGSSEIEEGRVMISGASSVSEGRASKTNAPPLFATGLGTPWPGGIEKLEKDRKAVEAQRMTELIAETAMYLELDAGLLGAKKSTETQSVSPILMGQLSTDDPESDEDEEPPPEFDWDGCSPDQMLVFTSEDLPILLDVVVSHFKPVRRRSHRMIPANALFLCARYAHRYGPPELFEELLVGAMERIEAALHDRPDDMAVSLFWLSNSLLLLYYLRKDTRLYNATELLRVHLADLINVLFVFILRNAEQRFDKVLDMAILEYEGLPGLEDVDFEDEWRFVKKLTGRKSKKAGMVKSSSARNIFGGNDVTISPLRTPNSTQAPPPPAEATPATVTAMLSSLLFVLQIYDLPPSIIVQAFSQLFYWIACELFNRLLTQKKHLCRSRAMQVRLNASALEEWARTNRLPRRIVSLHFAPLNHLLQWLQCLSSETSVDGIIGTIQNLHALNPSQLLRAARDYRYEVDETKIEPECTEYLKQIEKQWERSRIQKMTEEVINGGARTASPVPPSSRSNEKRGLLDEGAEIDSSPELGRSPALRPRPLTPVQRTNGGVTPPTSPQSAEAEILEKVTKMIDEVFSDPELFDSYTPSGAAEAFGELLNSKYMLPFALPTSADLLLHFDSPDAFGAFATPTWGSVAGSHSHAGSIVDPMSPSKASHASNTAASDVGSIIIRTAFAPVLPEEFFNLLDAAKRRARVGNNVAEDLAGGWRSRLPSSDDEEDEDPEEGNASSGAVDGERAFDSVDVDATPRLPSSATM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MAF1</accession>
    <name>A0A2X0MAF1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C005g03355 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C005g03355</name>
        <name evidence="1" type="ORF">BQ5605_C005G03355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY74303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MAF1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY74303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="207" mass="22861" checksum="4EFED479FB51C884" modified="2018-09-12" version="1">MTLGPFAFASRRASQCSRLYRPGLLLTDDDFDRVSPLTNMTIAELLAFDVSCRSRRRVSSHRVVQGQAHPIIDLPYLTLQTRDAFLATDALTNARKNGYRPLAVASTSNGVETTATPLEIGSLICFGLELRLIEKACYFTHIDGTVPFCMIEGRQDIDTCAHAEQRLPPFGACPGREMPPVESLQAAQLPPRIQRAQVQENVSLTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MAT5</accession>
    <name>A0A2X0MAT5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g04324 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g04324</name>
        <name evidence="2" type="ORF">BQ5605_C006G04324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY57947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MAT5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY57947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="571" mass="62883" checksum="4BCF49C2CDE24860" modified="2018-09-12" version="1">MSAAPACGVGVPIRSNVQALWSPGTQGGPSQPRQVLGREGGSVPWACSSARCWAPRGSTLLFVPLRSTESAPRRAMTTIQPILALRHVYEPAASAPGSNRAQTPQAHVSIRDDLGPQTAVCTHCKARHWECERSKSTRHFSACCSQGKVRLPPPPQPNLEYRQLLQGSDSEAVAFRENARSYNNALSFTSLAAFWDQTQVGTLGPPVFRVFGRLYHRLGALIPAVNQCPAFAQTWLIDPAEATDTRLQGPDSAETRIQRSTLTKLESMLRTGNRFVREFASAKARAGWDTAKEWVLRLCLPPGRDRRTHNPPTSSTEMAMLICDSDTNTEDRGPQDLILQVHGDRCPDGRPKYQIVSSLHPSAMPLRYPLLFPAGEDGFHPNIPLCGFHQAGPPIARNREQIDNGVQLREVVAGLGLDDEDEEEDEDRDDEDEDGEEGDEEDGDGERPVKGSRWRVSRSQFFAHYLPKATSTSQSRIAPNVPSWTIPGCDGVRCQTWKASAAHHDDVRPRLTGNQGCTGADKACNRPDLIARVFEAKSGNKRHAGCFGNECKMNGFCFFAVFRIVFSEPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MBC3</accession>
    <name>A0A2X0MBC3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C007g04505 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C007g04505</name>
        <name evidence="8" type="ORF">BQ5605_C007G04505</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY60932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MBC3"/>
    <dbReference type="STRING" id="796604.A0A2X0MBC3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY60932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="880" mass="94050" checksum="940ACA3A94B8C550" modified="2018-09-12" version="1">MSPSVPKGKSSKDYAGAAEHGHCSDDADSSVPAQREPATGPIKAKPGRSRAACSACRANKQKCDGAIRHPCRRCELYNLECDAPLTAANSSNGTPNHKRAASITLPSLSPYAGRPAVPLLDLPPTPVASASLNETNGIHSSVLASTLRDIQDRLRQIESGLEVDRRARNSAAPSSSTASGSAQRATSTVSSSLSRLLDVEPPPESMPLHILLQTVDKIEALSSTEASVNEWVTGEEKMVQDTPSTSKPDAIARGLISVEDADAAFAFFHDRIAPWIPIFGDDADRSALGVQSRSPFFFHVVLCVTNYYNQATSERAREVYCGLTELVNLILAHQILAADPNLIGTDFIRGLLLIIYYKPVQHIAYAARGITDVGRATHSSKVNHWSSIMIHGIIHRTAEAIGLPRAPQAFLAALDASTVPGAPPIDNEVLCRLRTHYALCIADVHGSLQSGRVAATDPTAALETTRAFASLLSSPMDARMAAQLELYAIVRTPRGQHPFKLRLAQLGRINDELDSWESYWRPILTPLQNGGDMLAYTLFQGAANFVTFIANSATFTRWTIERQRSLDSGGNGRPVLTTSDWAHLQRATDSAMKTIFALSVESRASGDPLRTCRWADSVNGVRKPLTLDLVTVEDYRTALDTSTCISFVYSLILLVRMASAGLISSNLVCRRSDYEAGADLDTPKPLISGDKLPILLELGANFLRAISPNPQHPARKHAILLHMILKTGLGENSLAGTTTKSPASTTSPASTASMNVAAAASRAGASARTVPPVATADIETNPDGLLLTTMATVQDDAPSLDAWLFDLTAPNLPVSGGALLIPTAPGDATQEPGEALRSILTEVNPSFFGMGAICKLGLGIQVFDHSDELDQFASMDWGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MBP4</accession>
    <name>A0A2X0MBP4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C008g04986 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C008g04986</name>
        <name evidence="10" type="ORF">BQ5605_C008G04986</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY78896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MBP4"/>
    <dbReference type="STRING" id="796604.A0A2X0MBP4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000050">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000205">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000001">
        <property type="entry name" value="Actin, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY78896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="415" mass="46250" checksum="621A02B41BAB8E21" modified="2018-09-12" version="1">MEDAYLKYAAIIPTDEVAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKVNREKMTQIMFETFNAPAFYVAIQAVLSLYASGRTTGIVLDSGDGVTHTVPIYEGYSLPHAILRLDLAGRDLTDYLIKVLMERGYTFTTTAEREIVRDIKEKLCYVALDFEQEMQTAAQSSALEKSYELPDGQVITIGNERFRAPEALFQPALLGLEAAGIHETTYNSIMKCDLDIRKDLYGNIVMSGGTTMYAGISDRMQKEVTALAPSSMKVRSRWQSKLMVFLKLMKPFPQRVGGTLQVKLVAPPERKYSVWIGGSILASLSTFQAMWISKQEYDEAGPSVVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MDZ2</accession>
    <name>A0A2X0MDZ2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C012g06957 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C012g06957</name>
        <name evidence="2" type="ORF">BQ5605_C012G06957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MDZ2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY16707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="83" mass="8641" checksum="057448A8B973AB0C" modified="2018-09-12" version="1">MSANRALDVVDFGSLQVSCEPCEPLLVVSVSCDSYSGPVGRRAGIPRISSSAGKKFSLASTTTSKSTGVPGPSKRMPRTSNHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MFF4</accession>
    <name>A0A2X0MFF4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">carnosine N-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C037g11623</name>
        <name evidence="7" type="ORF">BQ5605_C037G11623</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnosine N-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="FQNC01000062">
        <property type="protein sequence ID" value="SGY94033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MFF4"/>
    <dbReference type="STRING" id="796604.A0A2X0MFF4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030735">
        <property type="term" value="F:carnosine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012901">
        <property type="entry name" value="CARME"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303:SF6">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07942">
        <property type="entry name" value="CARME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01296">
        <property type="entry name" value="N2227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY94033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="402" mass="45332" checksum="94D47D2F3FD59A3C" modified="2018-09-12" version="1">MTDEGTTEDPDSQTTATESESEAPNNDTEARHQATVVATFDSYRRVALSANQRRRADYFQLPPQHRRLLPGYAELLNKVDGLLSQNAHFLHAVVELNPFPPAQQIVDAEAPQEPDHERLRSTLRSVARDWSVEGAHEREAAYTPILNAFQELYGHYEAEDKAKLNVLVPGAGLGRLAWEIVNAGYTCQETNRVLNSFHSTTSINAHTIHPYLHSFSNIRTNADLLGSVQIPDVDPSTIASTSSGEFSFAAGDFLEIYAQPSQQAHFDVIVTCFFIDTAKNIVEYLERIWSLLKEDGVWINCGPTLWHFENTEGCNSIELSLEDVKALAKRIGFVLEVRSPYEWQFSSLYLAIDASTRSCWPSQNEREVRTSYTTNKRSTLRHEYAASFWTARKSVEEEVCVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MFR1</accession>
    <name>A0A2X0MFR1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C036g11535 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C036g11535</name>
        <name evidence="3" type="ORF">BQ5605_C036G11535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000063">
        <property type="protein sequence ID" value="SGY96019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MFR1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="309"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="888"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="907"/>
            <end position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY96019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1390" mass="156599" checksum="75FD80CF4A66D017" modified="2018-09-12" version="1">MFAIHLRRPPFPLPKDLSDHRPVSVVLVLSDERGDAAQPNNSLPTTSNQLHRINAATFKTAVFQGMLEGWLEGASGEEPVGELEVVLGNCEKEGRELARREHWERVERMAVLVGRVQDLEALPVMGDEETAEWTRTTEELRRAVNERARQLRIRAHVPEIATEERLSRPVHAKLAAWSSDSKITALRLPNGELTHDIDIALAHTQAHFQRLYDLEPRDQDHVERLRDDFLAPIRAARICDDPSSDPLFLGRLSEAHIELLQQPITEDEVVAAIATTHPGRSPGPSGVPYELYHTAPRAWAKALSRAFNAMTERGSLSPKQGQGLVRLLFKHHKIGADRAELSSYRPITLRECDYKLFTKVYVARLNHVLPDLLPPQQHGFVKGRRSADASFHLRLLIEELGARGTEFPDAALLSLDQSSAYDLVEHEWIFAIFDALGAPATFQRVLRMLYSGDSTTARYIINGFLTPPVRLTCGLGQGDPALSSVWDVVFQPFLDALHRRGIALNLSLPTIHPYPQSRAITSLAFADDVVVAVAGSESLTLLDDLALDWRLATNGRLNTDKTVVLPIGCRWEAGDRPLVVKAEGESLEWIGLSFDPTGNTKLANVNLVARLEAVLDSARDRGLTHHTRAFYVNRYTIPKILHILSADIPPLEVVKELDRILVDFVRGGKRRSCYGKDVVFTPRFKGDLGVMRMQDVVNSVAARVWDVLLGGSDAIWQGLARAAIVQAHPAPDFDLATDAWPCDYTPIRNNLHPRWQAVLKVPSAHNAQVKPRTLTLANLLALPIKLHTLHYLPGAPAVSRPPYDADYAAFAIYAKVADLFRRELYPGGGFHLWTPPTDVVVSNSKYDQRGRPQREHIVAWYRHAINRLRFTPIAQPVAAVRINGPPQVRTRSEVRPTTPLESILPHPIDPPQRLPRPALPDQSTQYNLLSMDRPYTIRRVRRVLNAKAFTDTIGFRDSLQPDNIKGFWKGVNSKALTAREREVWFKLIRNFTPTWSLQFHQKHDDSPACLVCGAPKDDREHYFFDCVDSGNVWIAARSVLCDALGLDTIDNTHYTAVQRMFGLPKLKASLRDQEGAGRTIEIFTGLVLEMISSGRWGMQKWGTRMEGVGRRRIILEESAGKFLGASSYLYDVAPRSLPLASTCFHEFLSLSLGFPATINRASYSYKNNYINPASRPVILAIACCLRLSNLNPDTREDRVKYFRDGTSQSDRKRFWRWLHDRFASAVEQDTHWRLMYDVTPTRKRQHTQGHASLPTCLFCGNDAAVIETVSHYFFGCAYSASYWSGILRILFDKLGIEDTDVDPSTFTQEQLTMGLPLLRGRGRTTSKWMWVRLACAIGFQRLHLLRWRVHQRFELDKDVAPPSLPSALRAFERDFLSRAGFVPGARDWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MG37</accession>
    <name>A0A2X0MG37_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C008g05302 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C008g05302</name>
        <name evidence="1" type="ORF">BQ5605_C008G05302</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY80096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MG37"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY80096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="138" mass="15431" checksum="3ED6E52B08554413" modified="2018-09-12" version="1">MSFASRPVQLPRLLSLLPRDGLNAIVYETRWAEMGIPVPTYSASKVSAPPTSRWEIKKVRLDFSGPKPKGRIWGVFYWKGERMTPDDVEYERVKGTLKYMWQSVLPPPLLVHEVRLGSKASPALDPALDPTAPATPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MGU8</accession>
    <name>A0A2X0MGU8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein transport protein SEC22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">BQ5605_C008g05111</name>
        <name evidence="18" type="ORF">BQ5605_C008G05111</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MGU8"/>
    <dbReference type="STRING" id="796604.A0A2X0MGU8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15866">
        <property type="entry name" value="R-SNARE_SEC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.50:FF:000007">
        <property type="entry name" value="SNARE complex subunit SEC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044565">
        <property type="entry name" value="Sec22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45837">
        <property type="entry name" value="VESICLE-TRAFFICKING PROTEIN SEC22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="16">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="17">
        <location>
            <begin position="150"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="SGY79357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="231" mass="26338" checksum="9617D75D6AD2C1A6" modified="2018-09-12" version="1">MVRSTIIARTTDGLPLAASNDDDEQDPKLPEYKQQAKMIFRRVTPQAEPRCSIESGACTLHYLISDSIIYLVIADKSYPRKLAFAYLSELSTEFARSYPPSSSLKPGLRPYAFVKFDTFIQRTKRLYLDPRGAEALGKGASTTNNGPSSGLDQLNEDLQDVTRIMTKNMEDLLWRGDSLDRMSTMSSSLRDESLKYRKAARQINLDALYRKWAPVGVLGLFFLFVVWWKFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MGY9</accession>
    <name>A0A2X0MGY9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C008g05340 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C008g05340</name>
        <name evidence="1" type="ORF">BQ5605_C008G05340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY80259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MGY9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY80259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="87" mass="10142" checksum="065C50101988B53F" modified="2018-09-12" version="1">MGTSRAFALRWPWTQCNSSSEKSGTVRLCALGVRSCFGPDWLRESAFMRRQNWDSEQQNNILVNFTDCVNGTRFNQEQNEQYKMRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-10-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHC7</accession>
    <name>A0A2X0MHC7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C016g08227 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C016g08227</name>
        <name evidence="2" type="ORF">BQ5605_C016G08227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY21360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHC7"/>
    <dbReference type="STRING" id="796604.A0A2X0MHC7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013726">
        <property type="entry name" value="Mitofissin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28075">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28075:SF1">
        <property type="entry name" value="DUF1748-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08520">
        <property type="entry name" value="Mitofissin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015970747" evidence="1">
        <location>
            <begin position="23"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY21360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="133" mass="15265" checksum="0EBD94CB55019715" modified="2018-09-12" version="1">MFGFGRLMHLAFDVLLVSACLAGIKRSTGLSPALTRIGSKDLRQLFVTYLELGEWVMDLSMWCCDGKIERFREEAIVVADRWLGHEQLRREGAEDDRWGRWETNDVFVLLYSRPASSCNFTTSLLFVNIMPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHN1</accession>
    <name>A0A2X0MHN1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C031g10908 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C031g10908</name>
        <name evidence="5" type="ORF">BQ5605_C031G10908</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000068">
        <property type="protein sequence ID" value="SGZ05997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHN1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF24">
        <property type="entry name" value="RLPA-LIKE PROTEIN DOUBLE-PSI BETA-BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015861645" evidence="4">
        <location>
            <begin position="24"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="449"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGZ05997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="585" mass="59279" checksum="DD1318D3C4075B2B" modified="2018-09-12" version="1">MVVAAPFISALLALAPLVAEAVALPAIKNSLFQRDTNDGYPVLRDLRKRAITCDADSDCDELTIPANAFAVCPGSICSYRCNEGYAFNFWPEPSCVIDGNSLASARILAVVVHSSSSTAAAAKTAAEVSVQTDAATTAAAATTSAAAAVAAATTAAAAATTPSRAASASASASAASGLAAAATTAAASRTAAATTAAASRAAASIVAQVVTSIVTVTAEPVTITVLATPTAASAAAVKTVTVTVSVNTGSGSSSSNDSYVYSSGGNVATNVGSSQPLNYTIPLSLPANTSIIAANIAQNNITGFGAQNLSNNTGAIASWFRTNNSADSTNGHSWCYNPYNDSMPGFAPSYKTMVSNYGGDPIKAGEAYCGLEAIFYTPDGRNMTLYVIDAFDDKWVKTPSSVDVVIGAFPELMGARPASKNDVIMDVKWHFTGNRSTDYIFNNGKNAGTASSSSASTSSSSTTTTDSAGDVAAAPSTTKGNFTAAYNGTATYFEQKGVAGNCGQVNLDSTPLVALTTQMYSAGQNCGREVRICATDTSKCVDAVVADSCPTCLDAQDLDLSVAAFKALGNSLSDGVISMVWNYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHT2</accession>
    <name>A0A2X0MHT2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C031g10945 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C031g10945</name>
        <name evidence="2" type="ORF">BQ5605_C031G10945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000068">
        <property type="protein sequence ID" value="SGZ06457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHT2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026960">
        <property type="entry name" value="RVT-Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13966">
        <property type="entry name" value="zf-RVT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase zinc-binding" evidence="1">
        <location>
            <begin position="106"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ06457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="266" mass="31071" checksum="947F0B8C1A2F6D16" modified="2018-09-12" version="1">MSPSQNKKKKWSRVGQLLKAKALLPKTALRPARIPLKEAPRPRCFNFFGLTRPFTIRKLRRLVNVVRFPGREDRVKRFRDGTSQSDRKRFWRWLHDRFASAVEQDTHWRLMYDVTPTRKRQHTQGHASSPTCLFCGNDAAVIETVSHYFFECAYSTSFWGGVLRILFDKLGIEDTDVDPSTFTPEQLTMGLPLLRGRGRTTSRWMWVRLACAIGFQRLHLLRWRVHQRFELDKVVAPPSLPSALRAFERDFLSRAGFVPGARDWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHX9</accession>
    <name>A0A2X0MHX9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">BQ5605_C009g05492 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C009g05492</name>
        <name evidence="13" type="ORF">BQ5605_C009G05492</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY81340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MHX9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000838">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF356">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER ABC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="509"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="603"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="640"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1018"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1062"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1150"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="346"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="695"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="1045"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1338"/>
            <end position="1577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="71"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="431"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="935"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="438"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="935"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="956"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="969"/>
            <end position="995"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGY81340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1604" mass="176214" checksum="E54314C83CE66497" modified="2018-09-12" version="1">MTMEASMASGPGFLLQHPASALSGSSSLPSSSSPPSAAVVIALAVALLISLSASVWSVYASIRDAARAEDHLKNGPNNHPEHDLLLDDSDEDEREHRDDDDTDGDDQRPSLAQWIREAARLVLLAGLLGVTTAKLPVESHASTWLVLWEVELIVLAVYLTSLSLLGVLHIVPPSLSRLQQGPLALISLVFLAIRHILPYFLQSRPHASVVSSLGVAQTAIVAALFLIVLSTPPDWSPVLPKAKAHPAQVASPLSRLFFTFLELRMIRYYLGSSRRSSSTSASEDFLKYVPVLPDILHTQHVLHHFRWRGDEPRASANDEERVDQDSATIGGVCAFMWTFRIELVKILCFATVWVLALFVSPLSMNLLLRYVQGQDTTNVSPYLFVFGIFGAPIVASTAYQGATYRLSEIGLRLRGLLGHAVFEKLLRVKAGGGGSKEDGEDVDDDDGLDEEVTEDGASTDSAPSPTSSGSKSGGSEAVGRVNNLVGTDIDVITSSLTTSLQLFGVLPKLFVSLLFLYFLLGWSAFVALASIVAFAPMSTVVSRKYGAVQEEIMKATDKRITIVQELVSSVRIIKMFAWEKSMMGKIYEAREIELRRITKRAKVYAGMMGLSTGVPMVVTLSTFGAYVFGMKQTLTASTAFTSMSLFGLLREAVISSTYLLSAFMRAKVSLNRITRFLSDTEELDSSPRSFEGDTISFKNAVFRFSRYNSKGSQPFELFVNDLTIPMGKTTIIAGDVGSGKSALLLALLGELHRRSGEVKFPARVKTSFAAQSAWLLDDTVKANILFGEKYDKERYEDTIRACSLEEDLKGFEEGDETRVGEKGVSMSGSVPLHFDLDILSFLFDSCVGSTVRGQKQRVALARAVYSQSEIVLLDDVLSAVDSTTVAAVVENCLNGPLLAGRTVVLVTHFVKLCTRRIKNCEHVVTLHDGEIESIETPEKRDKKHLSPSDAPGMRRTSSNISTTSSFDQRVPKSKKEEDEAAIKKKEQEQKLHGGDEGDAGTDISFRVYKKYFTVMGGWVFWTLYALVNLVAHVFMLSQFFILPKGWFIGRWVNAEDRDSHKVVYFIFYSLIQLASAVSLTAMYLVLIFGAIRASRTLHGRLTSAIFGAPFRFFDETPQGRITNRFSKDTEILDTEQVENLQPVLDYSVQVLFVAITISVILPVFLLPAALISAIFFFLGRLYILNALAARRQVASARSPLFSTLGDASTGVTTIRAFGREKAFSTQYRDQTDRYNQMQLYELGLDRWLEERSDMVGATVSFIVGLLALRAGLSSGITGFLVSTGLEFTNRILYVVRAINKNELSLNSVQRILEYSDIEQEVQASDKGDPPKDWPVGSIEFNKYSARYSHDGPDVLHELSFKIKAGEKIGIVGPSGCGKSSLSLALLRFIIGSNGEILVDDRKVSETNLEALRSRMTLIPQDPTLFSGTLRSNLVPNEEYDDAVLWAAVQRSGFAGHEGDAKNRNKGMSLDTVVQTGGSNFSQGQRQLLSLARALVRSSKIIILDEATASLDNESDKTLQEVIRSEFKRCTNLTIAHRLESVIDFDRILVLEHGKVVEFDTPTRLLENQKSAFYDLCQSSGNFDELKQAAAAGAGHAGSKGLAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MI54</accession>
    <name>A0A2X0MI54_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C011g06397 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C011g06397</name>
        <name evidence="1" type="ORF">BQ5605_C011G06397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MI54"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY12121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="104" mass="11768" checksum="15353E2A1FAEC273" modified="2018-09-12" version="1">MVGMWTPDYHTPKEFNLKDAFRLIQAKTQSNTTVWGRLGPAKQQDIVKYVSCAEPASLVRNVRLFGHSLVILFQIHCSTTVRPVGWRESWDGFPGRTSQDCATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIC2</accession>
    <name>A0A2X0MIC2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C011g06467 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C011g06467</name>
        <name evidence="2" type="ORF">BQ5605_C011G06467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIC2"/>
    <dbReference type="STRING" id="796604.A0A2X0MIC2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="1">
        <location>
            <begin position="69"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY12324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="155" mass="17753" checksum="4E94F78C05D4ABE5" modified="2018-09-12" version="1">MDRFDGPYRIVKAQPEISSYTLQLNGDDAAVPFFHTGKLKTYRKNDTALFPNREPARLGPVDVGGEPEYIIEDIVDERIRAGKQQYLVSWLSWPSDSNSWEPAEALEDTEALDRWERRNEEVNQDPVADCELRLQFPYLVALVGLSNLRNCQVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJ07</accession>
    <name>A0A2X0MJ07_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C010g05834 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C010g05834</name>
        <name evidence="1" type="ORF">BQ5605_C010G05834</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJ07"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY13324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="95" mass="10690" checksum="92DDB2EA05875FDE" modified="2018-09-12" version="1">MLLFDRQPRLDPTVLLLLTSSTFAESTSEIWHFVEFLRHPAVRDVMTGIIKDKHKESIVRNMFDYLQVLLLSPPFCLDLKSRGGAATMVAPAASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MK18</accession>
    <name>A0A2X0MK18_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL2m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C020g09212</name>
        <name evidence="11" type="ORF">BQ5605_C020G09212</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000082">
        <property type="protein sequence ID" value="SGZ18929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MK18"/>
    <dbReference type="STRING" id="796604.A0A2X0MK18"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000001">
        <property type="entry name" value="50S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000128">
        <property type="entry name" value="50S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.950.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005880">
        <property type="entry name" value="Ribosomal_uL2_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_uL2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01171">
        <property type="entry name" value="rplB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="10">
        <location>
            <begin position="112"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="9">
        <location>
            <begin position="271"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="372"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="424"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGZ18929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="434" mass="45778" checksum="F877CECA2ABB4527" modified="2018-09-12" version="1">MATALARRALSQRIALASTSSAGLSSSSVPAATAIAKASFSTCVPSAAPPPSSETLRPRRQLTFTKKSGQSNFKTFLPISPGLRHLRQPISEHLHKGGPHRPLTVAKRGTGGRNDSGRITTRARGGGHKRRIRLVDFRRIETGEQNVVRIEYDPGRSAHIALLQHRQTKCFSYILAPAALRAGDVVQSFRSGFPDSFMIAPTAAPTTSVPSTPVVDPGAPQTVLPPSSALSLPGVRLAPVPAREAPTPSAPSRASTSMAQIDLGVLRSVAIRPGNCLPIRMIPVGTVIHAITLAPKGAAVLARSAGSSARIVSAQSASGKHAQIRLSSGEVRLVGLECFASIGTVSNADHQHSNLGKAGRKRWLGFRPQSRGVAMNATDHPHGGGRGKSKGNNHPMTYNAKGAKGQRTRAPSSKNGNKFVVKERPKRSEKRRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0ML08</accession>
    <name>A0A2X0ML08_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C002g01545 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C002g01545</name>
        <name evidence="1" type="ORF">BQ5605_C002G01545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY33774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0ML08"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY33774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="72" mass="8072" checksum="7FA117F9C2E9A24B" modified="2018-09-12" version="1">MARVVFIPSKYSLNPRYTHPTEQKPINCMTPKTCCFSAEGRLLSDHPPLLKSGGERLVKVGDDVAVEERKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0ML99</accession>
    <name>A0A2X0ML99_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C012g06709 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C012g06709</name>
        <name evidence="4" type="ORF">BQ5605_C012G06709</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY15944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0ML99"/>
    <dbReference type="STRING" id="796604.A0A2X0ML99"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="2">
        <location>
            <begin position="210"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY15944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="290" mass="33335" checksum="8B67693E4EF8E0DD" modified="2018-09-12" version="1">MLDIRPNLSTAFHPKSDGQTEQTNQILEHYLCHFCNYHQDNWHDLLPLAEFSYNNSFHSSIGMTPFFASRGYHPRLEVTLQETPVPDVQQHLAGLYNAQQLAQDQICCSQESHARYANLRCAPTPPFVLGQKVMLNRRNIRTTRPSSKLGPFVIKRIINPVAYELDLPLMMRIHPVFHVSLLKPYRPNTLPSRQQPVLPPPNLIDGQEAFVVERILNSRVCHGSLQYFIDWTGYGPQDREWVDTSNFDDDNALVLDFHHSKPCKPGADCIQHLFDQLYYVSDVVIAKSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLI9</accession>
    <name>A0A2X0MLI9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C023g09756 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C023g09756</name>
        <name evidence="1" type="ORF">BQ5605_C023G09756</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ24978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MLI9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ24978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="349" mass="38646" checksum="675822276EEB7DDE" modified="2018-09-12" version="1">MSLARSCGHLARLTGVRSTTSTAPSYFTRPTASHRSIHAFTPTAPRSFSLASRTIPRDVTGSADPFQRCSTVLKKKAGKKNAASAVSDAFDALEFEEDLIDDIDSEPTTTSTSNNGKSTSDYPSLHAYLSKRLELPHFAFKSNIPSVSAVKGLLHLTARDDRSRTLQLLKLWRQRNLPYPNSETSSEFVRSWTRMNEIEEMVQVLARRDLYGLGLVQPGDFVNALQKLTTVEGEVADAKTLMPKLETAKTIQELLRLEGVNDLTAVVSTLAMALRLNESKAVRRLPALIDDLLAEVREMDSEDAVKSLKGVPGVERQAWVVKKVQECQNRVAEPKDRALLGRILDKVQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-11-27" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLR5</accession>
    <name>A0A2X0MLR5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C029g10642 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C029g10642</name>
        <name evidence="2" type="ORF">BQ5605_C029G10642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ15093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MLR5"/>
    <dbReference type="STRING" id="796604.A0A2X0MLR5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF5">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="67"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ15093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="319" mass="35607" checksum="02DCFD1C92D204B5" modified="2018-09-12" version="1">MSTSSAQYPPFAVSLFQRHDGYSFGYKVLGREHLGAKTPLVLVQGLSAVGLVDWLPLAQHLGNARPVLIFDNRGMGSSKIGKGHVADAFSIRDMSMDVISIVKVQTRLGWNEIDLLGFSMGGMIAQAVLVEDKIHRSFKIRHALLFATSAKAAHSDLLAAMPKPTEKKLTLDEKKELIRPFIRVNYDPKFVASPRNHDLLERRTMESVMTRRPARTIAHQMQAIAKYDVRKQIPSVPTSTPVLVVHGTEDRSVYFTELDYILRGIKHAQVARFGGMGHSWADYYTPQFWTEFISAFCDDQPIDGFVKVGEHGMANAAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MM83</accession>
    <name>A0A2X0MM83_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C025g09996 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C025g09996</name>
        <name evidence="2" type="ORF">BQ5605_C025G09996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000087">
        <property type="protein sequence ID" value="SGZ26923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MM83"/>
    <dbReference type="STRING" id="796604.A0A2X0MM83"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="699"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="764"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="870"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="970"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="418"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="472"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="571"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="626"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="925"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="991"/>
            <end position="1002"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ26923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1002" mass="106514" checksum="108B759148F33514" modified="2018-09-12" version="1">MCDSDSATDGTQTWITQPPPADDDAIFLASLDAYLLPMSGDDIDLNLNSNAVTAAEQISVLEMAPAALLGSTSKAAPAPASTAPARGSIRFGRDPRFANGVDVDAESEMLDWHPSYVTESTNDLSILSATDSEPLLTHPRPDELWETTPRSVSFASSTSGSAMERAAPADWQDLIEPAMRRGGEGNGLSFCSSETTGFTVARRAAPRDAAQEGQTLHPTHGARELDLDRLNCECNLAPGPWPSSSSSSTAAFPSASLPRSASFHVPEHSLHPQSHLRRSSYIEPGQYLQQQRKQQHWSSPSFFDPGAASSTEGTPELSPAASIASSASTGTPTAASATLYDYSPPPSPTVINRRRISLPGGTLTPNRNYSSVSSVGPLGSPLAGRSRCAPLPPPRSSTRPTSVHVSSAFVEMQDVYLQQQSPPSLPQQQCQHHSQSHDVLASGLMFTSSTPPRPSSFVAPSQMDALYRSASHDSNASSASPSSATSYASAPPLLSQTHADLVLVESSPLLRASSSNGEAQSGNTSLSGRRSSHRPAPIKIEASPKVRRQASRLSIEVPPNYLQQQPNRAHPLPGGLASPSSPYPSCPEAGSTRPMTPTQQAASQRDMEQLLGQLDNFLGPEGGGASQSMQEAMSSSPGRPIVPLRSPRGAPHLSIPSRMQNSLSSPANFGIASFEISGVTLNEEDLALLDDAEFHNQFNDSSKPYPASAPAWQTTFKPGPQPGQYGGPHPSQQVSYASRPAQYTAPMGSHQMGWSHGAAYQYDSATNTTGGPPTPTTPRYQVSAMPTYQRRESVDPDSLSSPVRRRRSSDGLSAHPTYYTATQHPNRMSYPYFEQQKQLQAPDYQTQRAPYTMQEQYSYGYAATSASSVAGSSSSSFYPTHHHPSSMPRPMVYSSDKFVQPDSPVSPPKSPTKRARISPPKSTVPLPPPSPVRPPLTSSMSSPAVPTVRTKKSGGLAPMFINYSANDKKKLLGGVAPSGSSKKKREEAEAAAKAAAAAAGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MMK6</accession>
    <name>A0A2X0MMK6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C028g10500 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C028g10500</name>
        <name evidence="2" type="ORF">BQ5605_C028G10500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000080">
        <property type="protein sequence ID" value="SGZ12374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MMK6"/>
    <dbReference type="STRING" id="796604.A0A2X0MMK6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="419"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="600"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ12374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="648" mass="64535" checksum="BF1895BE795CB5CF" modified="2018-09-12" version="1">MFGAFVTPDNSTTNATTPDSSTDASNTSGTASSTSDTLSPSSSDRKKSKSSDGTSSGSNSSATDSSSYNSSNTGAGSKTDSNDAAGNATTPDSSTDASNTRGTASSTSDTLSPSSSDSKTSNLSDGTSSGSNSSAADSSSYNSTNTGAGSKTDSSTDASNTRGIASSASDTLSPSSSDRKKSKSSDGTSSGSKSSATDSSSYDSSNIGAGSKTDSSDAAEASPLPSPSPSPTPKHKSKNKAKATPELGTPVNTTYYTNDTSTSTPEKSTGSTGTGWNTTLASKTTPTPDSGSQDATDSGVDNSTLSLNATTTPNTLNATTNGLSASNDTDATTSLNTPSLPASDSTQSDSDGVDSTNVLNTTVAKSTVGNTTGYNASNPFNVSVTSTSDNNTNSTAGLDGTNTDDSPEGTNSTSTPDQLNTTSTLNTTDATSVDPSSLPNSTFDVSTTNNSNSAFAGTGANTTAGTLNASTLTSSDATTTPNITIPDTTTPITTASTPDTITPNTTTPMTTPPNATTPITTASTPDTITPNTTPMTTHPNTTTPNVTIPDTTTPNTTTPMTTAPNTTIPDTTTPNTNTPMTTAPNTTANYGTWEPPHQYGNTTTSTNDTTTGTTVADTGAATDSTNTTQLDEGSNAVNLTSTANATRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MN66</accession>
    <name>A0A2X0MN66_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C029g10681 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C029g10681</name>
        <name evidence="1" type="ORF">BQ5605_C029G10681</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ15566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MN66"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ15566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="59" mass="6926" checksum="CA530A5EB01A1459" modified="2018-09-12" version="1">MYCLVLTWTEFPRISKTGYHTTAVMSLLSDLVHLRTIEVSPLQCTTLEFRLRVKPRVHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNA2</accession>
    <name>A0A2X0MNA2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C003g02257 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C003g02257</name>
        <name evidence="8" type="ORF">BQ5605_C003G02257</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MNA2"/>
    <dbReference type="STRING" id="796604.A0A2X0MNA2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF10">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="48"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY39648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="357" mass="39093" checksum="F26149CABB207C16" modified="2018-09-12" version="1">MSSTQSTSAQSTLTPATTPNKGALGSIGLRGSYEPLVAKGLLDGYKSSDVTPVIGRQYPDLQLSELLKAPNADELIRDLAIVISQRGVAFFKNQSLTIHEQKELGNQLGALSGRPSASGLHIHPTERSAELPNDVSTIYSQRQAYHKHRTALGRLASRGWHSDITFEPIPSDFAILKIKTLPETGGDTLWASAYEAYDRLSPAYKKFVEGLTAEHEGNGFHQVAAAQGTKVYSEVRGSPANVGNDLRAIHPVVRTNPITGWKGLFINQGFTKRIVELTKEESEETLAYLFKLYNQNHDLQVRYRWSKNDVAIWANGPTVHTATSLTTILNLSAAVKLSVSNRSFDNTNASSLFILHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MP07</accession>
    <name>A0A2X0MP07_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C021g09278 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C021g09278</name>
        <name evidence="2" type="ORF">BQ5605_C021G09278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000083">
        <property type="protein sequence ID" value="SGZ20451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MP07"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ20451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="266" mass="29105" checksum="2917E22E0E5D61AD" modified="2018-09-12" version="1">MPSIRLEKGNSLIEYVTTVEEASWHDLVHIEVLVLRESILASLWNFGCLLYVLQRISPDSPTWGSMLGTMWELLSPANRDLRLPRESRILLALIWLPLMLGVSAGARVLGLLGQHRSEWPETSSGMGKVKICVVALATTRELPPTIASLSFALIDGEGKDLPSGCLNIVCGVAADLTVYLASLGDPVAARMTMLFVTFGLQVLFLAASSIPFDCIGTIYLSGSQAPLLPTSMTMRDSLDEKEFDISPHRLVIDVDSMEERLIGDTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPM7</accession>
    <name>A0A2X0MPM7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein RER1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C049g12427</name>
        <name evidence="8" type="ORF">BQ5605_C049G12427</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the RER1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000111">
        <property type="protein sequence ID" value="SGZ30669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MPM7"/>
    <dbReference type="STRING" id="796604.A0A2X0MPM7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004932">
        <property type="entry name" value="Rer1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743:SF0">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03248">
        <property type="entry name" value="Rer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016013">
        <property type="entry name" value="AtER_Rer1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGZ30669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="201" mass="22835" checksum="CFBBB4BC95FFE595" modified="2018-09-12" version="1">MDATEPAPGANAVESAKKQWQVFQAALDRTTPHTLRRWMSTLVLFLVFFGRILWAQAYYIVCYALGIYLLNLFLAFLQPKFDPSVPDIAESDIADGAPGLPTSMSAAQAQSSALNGTTDSGEFRPFIRRLPEFKFWYSATKAIAFSLLATCFPLFDVPVFWPILLVYFCVLFFITMRRQIGHMRKYKYLPWDLGKTSYGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQ18</accession>
    <name>A0A2X0MQ18_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Guanylate kinase</fullName>
            <ecNumber evidence="2">2.7.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C047g12304</name>
        <name evidence="10" type="ORF">BQ5605_C047G12304</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the guanylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2"/>
    <dbReference type="EMBL" id="FQNC01000113">
        <property type="protein sequence ID" value="SGZ31096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQ18"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:GMP kinase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Guanylate kinase 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Guanylate kinase 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Guanylate Kinase phosphate binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GK/Ca_channel_bsu"/>
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        <property type="entry name" value="Guanylate_kin-like_dom"/>
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        <property type="entry name" value="Guanylate_kinase"/>
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        <property type="entry name" value="Guanylate_kinase_CS"/>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117:SF13">
        <property type="entry name" value="GUANYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117">
        <property type="entry name" value="GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GUANYLATE_KINASE_1"/>
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        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="9">
        <location>
            <begin position="8"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGZ31096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="210" mass="22812" checksum="4C04D7A98A77D719" modified="2018-09-12" version="1">MSPLPAALRPIVICGPSGTGKSTLLQLLFKDYPDKFGFSISHTTRSPRPGETNGQSYHFTTRDKFLKLVQEGAFIEHAEFSGNLYGTTVNAVEAVAKEGSKTCILDIDTQGIKQIKANHPSLNPIYIFISPPSLSSLRSRLTKRGTESSSSLTSRLSAAITEINYAQTADAFDVVIVNDDLKAAYEKLKKVVVEGDLKAGDKLPDFSSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MRT3</accession>
    <name>A0A2X0MRT3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C142g13436 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C142g13436</name>
        <name evidence="25" type="ORF">BQ5605_C142G13436</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000141">
        <property type="protein sequence ID" value="SGZ35667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="569"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="836"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="23">
        <location>
            <begin position="843"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="884"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="23">
        <location>
            <begin position="911"/>
            <end position="928"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGZ35667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1530" mass="166892" checksum="DD4DEFD9B861142F" modified="2018-09-12" version="1">MLWPFLSMSMPCFAGQLAPRFSLSCSSNFIGLVSLRGHLRARPRHFFFRASHGSAPPTLRTPGMSDSDVPKPTTLTVPPPRPPTQITAFAASDLLRDADGYQDWVLTLCSRMPSDVIDYLKSGVPPTSWPPAYVPLWDHYARASICAAVDPRLVLPGLSQYFGDTHSGHKIWAALRTRYGAVSAVDLLPVISRLFSPDLMPDTADAFLQFRDRFENDSRLLNDSDVTTDSLLASHLLARMPPSLSAWRTTFVNSQGTSRTLPHAAEILDRIYREIKARPIDPLAAATVTATSPQRTPPSPCPNPTCRKMHWLRDCPDTTWAAAFRARKAASGTTSRAHKKGFRTIASPAVTSPTDTERPEPTTFTACLLATPSAFPKSAWLLDSGANRHMANDSTLFSSLRPFTGPHVAGVAGSLPSTGCGSVRLSTSAGPVVATDVLLVPSLPCNLLSVRRLDRLGFTVSFGSGHAAIRNSSGTVVATARAIANDLYALNVAPSTCMPNALLATPHRVSLLTLHRRLAHLPVAQLKNVVQKGLVTGVDWVYSEEEFRSFHCNACLASKAHALPFARSKSIAPGRLALIHVDVAQMPRASFGGHRYMLVIVDDYSRKQWCLLLTYKSDVFHRLRDWILEVENATGDRVKTIRSDNGGEFTLRTFVDFCVAKGIRRELTIPYTPQQNGRVERTNRTIKEGILALLYSAGADTRLWAEAAKYFVHCKNLLPHAGIHGEVPDTRWYGMAPDVSSLRTFGCRAWHCLPSVKRTDLDPKAVPLIFVGLDDHAKAYRLFDPATRKILLSRNVVFRESEFPALQPAANTTTGATPLPVAAEVYPDQVDHSEPLLVASPRSPAPRAAPPGPAPVASDQGLRRPSPGRAVPDQDSHAPPASDQGPSPASDQGSPTASDQGSSDSAISTPCPSPRPVVPRPLPAPPSPARSESPDPIDLLPRSSDLASFCLAPEFPDDLDDALHSPPPVAYLASGAAALLNNAPPDSTELIAPARDPPHWRAAMATPQADEWRLAAQAEFDSLSRDFSAFTPIDESLVPADAKILGSRFVFRTKRDQHGQVKSYKGRLVARGDSQRSGIDFDETFAPVAKFTSIRALLALAAAHGYHVHQADIDKAYLHGKLDKPLYIRVPDGIYMPGKVLQLHRSLYGLRQAGRIWNDEIDSALSALGYAATESDHCVYVRTAGDERHYIALYVDDLLMISPSLPEIERTLQGLEQRYGVKRLGEAEYILGIQIRRSDDGSITLSQEQYLKDVLARFGMSDAHPVATPMQPDLRLEVELQPTPFPDRTRYLQAIGSLMYASTGTRPDLAYTVGYLARFSRAPSTAAWGAIKHAFRYVAGTLSHGLRFAHGASPPLVGYSDCNWGACLSSSKSTMGYNFIYAGAAVSWSSRLQSRVADSTCDAEYLGLSHAGKEAIFLRQLFGELGLSSSEPVLIYGDNQGANALTKNPVFHARTRHIRLREHFVRDMVSLGDIVIQYITTSEMTADIFTKALSRDLFARHRGRLGAGQLAPRFSLSCSSNFIGLVSLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MSE1</accession>
    <name>A0A2X0MSE1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g03828 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g03828</name>
        <name evidence="1" type="ORF">BQ5605_C006G03828</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY54002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MSE1"/>
    <dbReference type="STRING" id="796604.A0A2X0MSE1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY54002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="149" mass="16512" checksum="F3A3A474A0BB431E" modified="2018-09-12" version="1">MRGIFQFGLGSKQFANLLVTAHRAAHDRLEVDYRSAILAREADLPSTSLYPALGDWEDPTGNCGHIPNSQALQEFYDSVMRKQETLLNHAESLKPCSIMTIDHSYKVPKQIAKVEGVPPFIALLMVGNEYGEVRAHVLTSTKGHSAFET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MSK2</accession>
    <name>A0A2X0MSK2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C006g03898 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C006g03898</name>
        <name evidence="5" type="ORF">BQ5605_C006G03898</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY54696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MSK2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="359"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="125"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="635"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY54696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1253" mass="139015" checksum="22B05FD007BE0D2D" modified="2018-09-12" version="1">MELSNAKYDEDENMGEFLKSMIDKADQLDDLGQKFGDEAMIAYILQALPPSYEMLKQAIRLGENRSVDHVINRLTDEYTERKLSGKFDKLLKNAGALAVQSTQASRDPNCVCRGCKGKGHFAMDPECPKYDAKKNHGRARNRNKKKKQDSKESADSNELAEFVLTVKSLDESHSLQDNVANRVSQLNQGEIWILDTGASQHYVGDASLLSNRQSGNLKVQTASGQVVHCDTYGMVRFKLKSGASLSLANVYHLPGAPVNLISTRALFKSGAKCGWEDGKDVMTITYQGVILAKTLSGTGYALDFTRIVEDQAHVATRATVGAPLMEWHRRYRHVPVSSIMELVKSGAVEGLVLTDEKVHDCEPCISSKSRASKFSELATQVTDVLQRVFMDIGFVAEDQVDFQGRKAYLAIVDQYSTAKWTFPLKTKSAEEVTRRVRTDNGTEFTNKLTGADFQSQGILHETSAPYTPQQNGTVEHFNGSLMAIVRAVLAASKLSWKYWSYALVYATFVANRILHAKLEGKTAYEVFYGKKPKVSHFRPFGSTVYAQVPKSKRSKLESTSVKGIFIGYDSEYNYRVLVDPDSDHKVIVTRDISVLEHKSEQVGVPEVTTLPVGPDEEKGPVDNDEIVVDELQDQVDGEQMPPARQNRPRWEYGDPAVKGRNPGRYEEIDANNEIPHCTRSQRRDAEQQVMYGSAMSASLPPVPSNYKEAMASPEADKWIAAIKAELDAMARHQVLIDLDLPSGARALGSKWVFTRKENAQGEVTRYKARLVAQGFAQRPGIDYNETFAPVARPSTILSLVGTAAAQGLFLEQFDFDSAFLNGTMTEMVYMKYPKGWDRPQTGQALRLVKSMYGTKQAPREWNAAVNSLMVERGYKRSDADSCLYVKRVDEKFIYITLYVDDGMVASNDQEFLDSEIEAFNKVYKLKRLGPVKLFLGLEFERTSDYIFVHQSKYIRDLVAMYGGGSVSKHLVKVPMEPRSDVEHSTDPFDDVALYQSAVGALQYAAHRARPDIVTSVCAAASKVSAPTQADWIAVKRIIRYLQGTVDWGLKFNHGGSTVFELYSDASWGDDMSTGKSIGAFVSILAGAAISWQSKQQSMVATSTTEAEILAASAAAKEAMWLWRLAADLELEQPKATLIWEDNQAVIAIALNPAHHGRTKHYNVHHFYIRERVTAGDIRIKYCKTGAMTADILTKPLARNLFELHCEGMGMVGAGARVLCGGPAEAAGCLHEIASFWPSCFSLFSTTHSISHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MSM4</accession>
    <name>A0A2X0MSM4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C046g12283 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C046g12283</name>
        <name evidence="1" type="ORF">BQ5605_C046G12283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000112">
        <property type="protein sequence ID" value="SGZ30965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MSM4"/>
    <dbReference type="STRING" id="796604.A0A2X0MSM4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ30965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="126" mass="14335" checksum="C0CEB3F4470CF756" modified="2018-09-12" version="1">MGFPFRKSRAPNPRASFFASASRKSVPCDIWQWPIYTVDFSSARAIDRAPRFDDFRLVPPFRVEKVDFSSARAIDLEKVDFSSARAIDRALSIFIFTGNLGFYSKTYPGIGLYPTYDTYILESAPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MTB1</accession>
    <name>A0A2X0MTB1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C043g12072 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C043g12072</name>
        <name evidence="8" type="ORF">BQ5605_C043G12072</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000117">
        <property type="protein sequence ID" value="SGZ32093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="7">
        <location>
            <begin position="678"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="1800"/>
            <end position="1816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="333"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="973"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1462"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1768"/>
            <end position="1787"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="341"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="989"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1484"/>
            <end position="1502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1506"/>
            <end position="1518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1549"/>
            <end position="1559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1769"/>
            <end position="1781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGZ32093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1994" mass="219775" checksum="712C19F2C4FD6E38" modified="2018-09-12" version="1">MRISRKAAIGYLIRSARLFSEAWRCAPTVCYGYYHMQLTDGWITRSSVSYLVASVLPQGTDPHAEKTQRISKMATPTADHVSLMGDLYGKVDATNWGVARERLQNVLKGEGRLKHVTGVLDVGPEPLQSEFTRLEGNNRVDNVATYRNQLRLYRQDVDALDQALAQARNTLIVCLGESTFARVKANATHDLWAALDKDLGRASDDFMRSAKLDALFLCEPFADGEALDPWLANFNRLFEDLVAAHVSRDKAYQRARIDGTSFTQSDFDKWVPPPALSEGVRMDLLKARMPRNLVTVIDSIGTLPSLKQVEGAIRRAALSSSRQIEPIAEALAARVQSRSQPASGRPRSKPSGRPSGPSAPPFLQASRVPGLKERWPHGISHAGRLKLGRMQCRRCYEQGHLGDECTVPSAEVSRRRIAVLAKHNITIGAADVMALVAVDRAPEAQLEDEAYEGYFVVGVPIGDDDTALYLSDIPRYLLDSGVTRHMTTRRDLLIDFKPFTTERVRVIGAFNSSAMATGTGTLRFGVDEASIELHDVLLVPGLSAELVSLAGLMKDGYELSNECDTAGKHTGIVISSATSRLSFALDRNHYVLQASSHPPPRADHLALTATTLPTDVVLWHQRLGHPSWGRLVELVRSGQIPLDVAAVTPDQIRLLDQCDACCAGKTVSSPNREPASHPADAPFSRVFADVWGPSPVPALSGARYLCGITDEFSRFRWARSIRLKSDLSAVLQDFVAMLKTQYGGQGVMTLRTDRGGEFVNHRLRDWLAARGIFHELSTAYEHGQMGVQERSWRTIFNSVLAWLHRSGLPPALWDEAAHAAIYVINLLPLSPLQQRTPDSVLHEPLDPVTDTRRPRLDRVKTWGCAAHVPLAPEQRPNKLAPQSRLCYFVGYSSQSKAWRFFDPVRNKVFELSQARFFEDHFFPAAVSPAMPAIPVAVGLSYPPAPLGIGSAAAPPVAEAPAVAPAAAAPPPVPPALAFSNPGPANAPPDGDRSTRTRRPPDYLGFAHAAQHWEFADHAAIQFNDFDEGDPDTQMYSFEEVSALLAKINSDDTPSVQAALAGPFRDYWLAAMSVEEGALAAKNTMWVLLVKRNAEGQIVKYKARLVARGDMQRRRGNEWETHQFDVSSAYLNGNLGGTEIYMRLPGGDIVRLQCALYGLVQAGREWYKVFTEWILSIGFTRTNSDHAVFVCKEGDRRSFLSIHVNDGLLMGDGDLDGVLCQLKARFEARSTDEASFFLGQSIRREGKTGAAIVNQGHFVDAILKEHHMANASPRPTPLAAPSTLRNRTDSGFDPASIPYCAIVGKLLYLSGTTRPDIAFAVSKAARFCNDFTAEHWEALKHILRYLVGTRNFGIRYQKSFQPMSAILEGFVDADHGADPVTRRSVSGYVFMCAGGAISWIAKRQTLVTLSSTEAEYVAMSYAARDGIWLRRLLADLGFEQTAPTRLRGDNQSAITLAKHPAFGLRTSEAREQSRAFQAAAKKKPNTNPTQTDTDTETDTIQTRTDSDTIQIQDTRTGTDTKIPLPQHERGPPTPTPAQPQEHQPKRRQDQGTNTAMSSGTRDGPPHTDNVARRVKLELPTLNAGFKSRDVTRWLAGCEDAIESAEWNYGGKIAAVHLIREAGCKMEGEGADWYIDCRNKVKALKSWPEFAQEVKARFINKTGLEAKHAFYNAHQTGTLSDFVATLIAARGQAGSIGGTQVISDELFKDHLLHRCDELLYLRATASPSFDVAKFTMNQLVAYLQSLWEAITLERATTGVRCMGLRNDQVRQEQNNSAAHQTSGRPMAGLDRTPRDKALHEGRCFHCDVHGHIAADCPSKPGTSLTPAPSRPTPGPRMVAAIREYQESGDSTAFVGISSDSEEDDARWLAFQTDKEDALISCLSPAFHARTNHIGIHFHFIRDHIAEGTIEMVWVPTGTMAADVLTKGLGTQKHYQKAAIGYLIRSARLFSEAWRCAPTIVFSPRLDYTLVRYVHLALRLLSYAINDGWITRSSVSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MWD7</accession>
    <name>A0A2X0MWD7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C004g02942 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C004g02942</name>
        <name evidence="6" type="ORF">BQ5605_C004G02942</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH3YL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY69022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MWD7"/>
    <dbReference type="STRING" id="796604.A0A2X0MWD7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11525">
        <property type="entry name" value="SYLF_SH3YL1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033643">
        <property type="entry name" value="SYLF_SH3YL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF2">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING YSC84-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="643"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="236"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="435"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="248"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="278"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="377"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="469"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="494"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="536"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="569"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY69022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="703" mass="73956" checksum="385DA69C2153178C" modified="2018-09-12" version="1">MSNPLPVSLPQECRKAAKLLNAFADRDEHRRLTPLAHVHHPTAGKGLDSIIPANVLRKAKVLGVPLGFAFLTVVKAGFVFSARAGSGVVIARLPDGSWSAPSACATAGGGVGFQVGVEMAEFIIILNSRAAVASFMAAGSISLGGNMSIAAGPIGRNVEGTGSISSKGKVAAMYSYSRTKGLFGGASIEGSVIVERSDANRQAYGFDVKAKQLLSGQVDPPAFADLLIDTIVRKSGGTSEHVQRSNSGDDDDNIYNDDDFENDSGHERGDSFGGDPKAYSFGSAYASGGSSSRPSTPGSPKMEKSLSSSKGFGSKLSNFVPGSASRSRSSSIATARAEIGAPTSSLMAKESSRDGPISTGTTRFETEFTNEFEQSDDPFKDGEHWRGSVDNRRSPAAKLTKASSPLTSYSSPRVGGPGIKDIGAVPEWEAQASLTRDSFDSLDDDRAERNGFGNRYDDGAQTDYGTIGGSSSSSGGRFRSSTVGSNTRPTGLFARARSASSPWSSKSKKAAAANARAASPYINERPSPFEDDDPSNKSTYSTRARSGSAGPAPWDSEEEGFYNTDDSPASRLRSSSRGAGRADESQQNITTTPRGERKDPFDFSEVDADFASSISSHHPGGAAGKRSGNSTPNRGRSRSGTIGGIGKAIALYDFPGVESTDLPFKKGDVITVLSCDDEEWWKGRLNLITGMFPRNRVEAHLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MWJ9</accession>
    <name>A0A2X0MWJ9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C004g03002 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C004g03002</name>
        <name evidence="1" type="ORF">BQ5605_C004G03002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY69357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MWJ9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025638">
        <property type="entry name" value="DUF4336"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835:SF1">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835">
        <property type="entry name" value="YALI0C07656P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14234">
        <property type="entry name" value="DUF4336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY69357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="261" mass="28934" checksum="FFCA070D32E34156" modified="2018-09-12" version="1">MATNAPAPVNPELVIRKLSESTTIFSCPFARGGLVPFGGRSTAIKLQDGNVWLVASHPLDPDTLTTLNNLGPTKFIISPDREHNIFLKQYIDAYPEAQVFVPLGVKENWQKKGENSLINRITFTFGQGKGDPFPALTNGEILSADFGKAHANEDVAFLHVPTKTLIQADLLFNLPPDEQYSKSTKKSTAFLATNLLRPGTIGHKRLVWYLMGKDKKVMTEQAKVVSAWDFDRMIPCHGNVMESGAKAAWNSTYNWYINGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N1V4</accession>
    <name>A0A2X0N1V4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C037g11615 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C037g11615</name>
        <name evidence="7" type="ORF">BQ5605_C037G11615</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000062">
        <property type="protein sequence ID" value="SGY93875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N1V4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="207"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY93875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="398" mass="43887" checksum="4F2CE59A53EF4FA8" modified="2018-09-12" version="1">MAFNSNSNEAGGSGAGAAAGGFSFTSYFQESERELPFNQRPLREVNALKFDRKRVDEEPNNPQLQQQQQLDRPLWQRLPAWVPIVCWIGTSSFIILQNKYILYDLKFNHPVALTTVHLTFQTLATRALRRYTPLVDKAKELEATGKMNRDVFIRKIIPVGALFSASLVLSNWVYLRLTVSFIQMYAGGFSLLLGIYLLLTLCRTFYYRIKAFTPVSVLLVSAAFGLKELNRKIMGIVGAISLGVAIASFAEIEFEMIGFLVQALAIAIESCRLVLVQILLQGMGLDPLTSLYYFAPVCLVINSIILLPVEGFSVFSDAIEKVGIPMLLGNACMTFALNLSSVWLIGKASGLVLTLSGVLKDILLISGSYFILGSSITGTQIFGYIIALTGLVMFKMQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N5H2</accession>
    <name>A0A2X0N5H2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C005g03716 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C005g03716</name>
        <name evidence="8" type="ORF">BQ5605_C005G03716</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N5H2"/>
    <dbReference type="STRING" id="796604.A0A2X0N5H2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF28">
        <property type="entry name" value="TRANSPOSON-ENCODED PROTEIN WITH RIBONUCLEASE H-LIKE AND RETROVIRUS ZINC FINGER-LIKE DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="7">
        <location>
            <begin position="175"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="278"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY77750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="297" mass="32333" checksum="677A7EB732B930A2" modified="2018-09-12" version="1">MVLDKSLFKNYRHIAPTKIGGIAGGINTIGMGNIAFVAASGHPITLTGVLHTPGLPVNLLSVSCLCDTNNVRVAFTKHGIHINKDGNNIAEGARLDKGLYLLDADHSKCQQLALLSCSQSSVPLLTLHRCLGHLAPSSIQKMVATGLLEGLGAGYSDKEVEKFVCNACLSAKGHRLPFPDSDLHSFERLGLVHSDVLSLPERSLTGKQYLVTFLDDYSCKLWAYAIGHKSKVFGMFKTWLAKVELETGATLKVLRTNNGGEYRSKAFTDSCKARSTRRQYSIPRTPQQNGRAERVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N651</accession>
    <name>A0A2X0N651_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BQ5605_C021g09292 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C021g09292</name>
        <name evidence="11" type="ORF">BQ5605_C021G09292</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M43B family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000083">
        <property type="protein sequence ID" value="SGZ20677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N651"/>
    <dbReference type="STRING" id="796604.A0A2X0N651"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04275">
        <property type="entry name" value="ZnMc_pappalysin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008754">
        <property type="entry name" value="Peptidase_M43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47466">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47466:SF1">
        <property type="entry name" value="METALLOPROTEASE MEP1 (AFU_ORTHOLOGUE AFUA_1G07730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05572">
        <property type="entry name" value="Peptidase_M43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015898345" evidence="9">
        <location>
            <begin position="25"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M43 pregnancy-associated plasma-A" evidence="10">
        <location>
            <begin position="223"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGZ20677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="340" mass="35473" checksum="E3CE7B556028E489" modified="2018-09-12" version="1">MLFLSKLSLLSLAVVALGPSVAFGAIAQVKDARRCGNEGSKPDAASEAVIKQATVKLSAAIAAAGRGALISSSSDSGNHRAAVTTVVAPKQIKVYFHVVRKDKTVAGGNLSPRAIAGQIAALNADFRASGFNFTLAGTDFTTNRDYFESAGPGSTQQTAMKNQLYKGGPSDLNLYSVGFVKGAGKGLLGYATLPFSISPNSRTANKDDGVVFLFSSVPGGSITNYNLGRTMTHETGHWLGLYHTFQGGCTGSGDGVSDTPAEASPAYGCPTGRDSCISSPGLDPISNLQVPTFLAVPSPGGPFRNRRASPMDYSYDVCMYQFTSGQALRMVAASQQYRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N945</accession>
    <name>A0A2X0N945_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C036g11549 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C036g11549</name>
        <name evidence="3" type="ORF">BQ5605_C036G11549</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000063">
        <property type="protein sequence ID" value="SGY96190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0N945"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="594"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY96190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1404" mass="157917" checksum="45FF280004626CFC" modified="2018-09-12" version="1">MKDGAEEDDEWRATEVEEEVEQEQGVQDNSTMIIDDDQTTITTVSRESTPRSPSWPPLSPETLAKSLREGAEWDRANTEAAARVQAEKEVIINAQLDAEEPLVCHQFAEWGQEDGQLRFINICGTGSRSNKKMKRSQTVADLSDPSDDPVNVKRVLNKVKGRAGKEVVGQGKRVTRSMLAAAAMQVEGTKAKAEKGKGVEEEKRWSDHEPKDDILPKFPLFEDDTTAKSTCMGIPEKRRNIYTYLSTFKASAILLQEHFIKPELWQCIKNEYEGKVFISKHCLTLIPADSPLIDTKILRTHSALDGQILVTSFRLRGDIRILEINNIYAPVDTKQRLTFFDKLHFHRTQSTHLRLLGAISMTARCRRSIGGTKRPKSFSRLDYFLLQRTHQKRLVQASTIYDHPKDLSDHRPVSIVLVLSDERGDTAQPNNSLPTTSNQLHCINAATFKTAAFQGMLEGWLEGASGEEPVGELEVVLGNCEKEGRELARREHRERVERMAVLVGRVQDLEALPVMGDEETAEWTRTTEELRRAVNERARQLRIRAHQPITEDEVVAAIATTHPGRLPGPSGVPYELYHTAPLAWAKALSRAFNAMTERGSLSPKQGQGLVRLLFKHHKIGADCAELLSYRPITLRECDYKLFTKVYVARLNHVLPDLLPPQQHGFVKGRQSADASFHLRLLIEELGAHGTEFPDAVLLSLDQSLAYDLVEHECIFAIFDALGAPATFQRVLRMLYSGDSTTAQYIINSFLTPPVRLTCGLGQGDPALSSVWDVVFQPFLDALHRRGIALNLSLPTIHPYPQSRAITSLAFADDVVVAVAGSESLTLLDDLVLDWRLATNGRLNTDKAVVLPIGCRWEAGDRPLVVKAEGESLEWIGLSFDPTGNTELANVNLVARLEAVLDSARDRGLTHHTRAFYVNRYTIPKILHILSAYIPPLEVVKEFDRILVDFVRGGKRRLCYDKDVVFTPRFKGGLGVMRMQDVVDSVAARVWDVIWQGLARAAIVRTHPAPDFDLATDAWPCDYTPIRTDLHPRWQAVLKVPSTHNAQVKPRTLTLANLLALSIKLHTLHYLPGAPAVSRSPYDADYAAFANYAKVADLFRRELYPGGGFHLWMPRTDVVVSNSKHDQRGCPQREHIVAWYRHAINRLRFTPIAQPVAAVQINGPPRVRPTTPLESILPHLIDPPQRLPRPALPDQSTQYNLLSMDRPYTIRRVRRVLNAKAFTDTIGFRDSLQPDDLKGFWKGVNSKALTAREREVWFKLVRNFTPTRSLQFHQKHDDSPACLVCGAPKDDWEHYFFDCVDSGNVWIAARGVLCDALGLDTINNTHYTAVQRMFELPKLKASLHDQEGAGRMIKIFTGLVLEMISSGRWGMQKWGTRMEGVGRRRIILEERLKLRAGGAWGRRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NCH4</accession>
    <name>A0A2X0NCH4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C041g11941 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C041g11941</name>
        <name evidence="2" type="ORF">BQ5605_C041G11941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000119">
        <property type="protein sequence ID" value="SGZ33196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NCH4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ33196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="169" mass="17666" checksum="258D558549B4FA2C" modified="2018-09-12" version="1">MPMPTAPSHSPTYSRPAAASAAPHVATAATGHSPITGGPRPVARLTVDERAYLDQNHGCYRCRTPNANHVSRNCPRYLSPMRASATPSTPTSTAPAPRPMRRSPLMSGEVGCRTEVVRGKLRNRKGARTGIGPAVGELARAPRQLRASKSPPQGGGLAGARPSPLAPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NDP5</accession>
    <name>A0A2X0NDP5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C022g09565 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C022g09565</name>
        <name evidence="1" type="ORF">BQ5605_C022G09565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NDP5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ22950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="210" mass="22891" checksum="CF71AC8E665F1D8C" modified="2018-09-12" version="1">MGIEKDVHWKLIFGATPTCVLQHHHGHAASDGCPQCGERDTFMHFYFECDHSQLRKIAPTTPAAWTLRRSRRLVGSAPSVCIAPLLASMRKFLPNRGQGRCKDPFEALQLAISRLRLWVQDSPSVAVEASWGLNGLYARVVGVKAADDPVTIQEEDSSLAAAVAIGEESEDFGTGLRRKELLNHGTMLETSPRDLVLSTLQGGIAGDGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NQI4</accession>
    <name>A0A2X0NQI4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C015g07771 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C015g07771</name>
        <name evidence="1" type="ORF">BQ5605_C015G07771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NQI4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY17397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="96" mass="10496" checksum="1F79CA545D34F194" modified="2018-09-12" version="1">MQWRRIHSLAVSQPARALTNAKPLTKRLSVRKLDSSLANVHLCMRMFAPLGSKSFVGGLGRLDEPCLSKGWALVHGRDLGAESIVKTTKYARHGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NRS7</accession>
    <name>A0A2X0NRS7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C011g06408 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C011g06408</name>
        <name evidence="2" type="ORF">BQ5605_C011G06408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NRS7"/>
    <dbReference type="STRING" id="796604.A0A2X0NRS7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="51"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY12159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="187" mass="21332" checksum="42A1FD31ED2DCDE4" modified="2018-09-12" version="1">MSKSNLPQQYRACPLLWAPLLTRAYNELITRGSLNPQQSQANVRLLFKHNKPGAARCDLKSYRPITLRECDYKIFTKVYVARLNRILSDVLPAGQHRFVKGRRPADAALHLRLLIDEIRGRGAEFPTAALLSLDQSSAYDMVEHDWVFAVFEALGAPESFQRVLRMLYNGETSTARYIVNGFFTDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NS15</accession>
    <name>A0A2X0NS15_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C017g08308 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C017g08308</name>
        <name evidence="2" type="ORF">BQ5605_C017G08308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY19779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NS15"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY19779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="264" mass="29214" checksum="0291E6150D1BA765" modified="2018-09-12" version="1">MNMTIAELLAFDVAPADASLHIELSKDELTHYSTLSSTRGPTSSCYTRGRPMESSDPTRGEAGVGVSNTEEGCTLTTNEIQKNAYIEDGRIQEKLPERDKQYGALAQHYPHFGSLDGAVTAATPLEIGSLICFGLKCGMHSLSCDQTVYGEEALSIGIVTTNHSNQDTLASLVLLSNVVVQELRFIEKAYYFIHIDGTMPFRMIDGRQQKGSLTTKQQASQQSKEGLFEAWSHAQHQPKRRAPQATSDRPPRARKRSERVFEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NTI1</accession>
    <name>A0A2X0NTI1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C010g06135 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C010g06135</name>
        <name evidence="6" type="ORF">BQ5605_C010G06135</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NTI1"/>
    <dbReference type="STRING" id="796604.A0A2X0NTI1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033934">
        <property type="term" value="F:glucan 1,4-alpha-maltotriohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004574">
        <property type="term" value="F:oligo-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000025">
        <property type="term" value="P:maltose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11333">
        <property type="entry name" value="AmyAc_SI_OligoGlu_DGase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000087">
        <property type="entry name" value="Oligo-1,6-glucosidase IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000002">
        <property type="entry name" value="Sucrose isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF179">
        <property type="entry name" value="NEUTRAL AND BASIC AMINO ACID TRANSPORT PROTEIN RBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="5">
        <location>
            <begin position="15"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY14307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="578" mass="67155" checksum="45F975678381EA32" modified="2018-09-12" version="1">MPHQRHWWKEGVVYQIYPRSFLDSNGDGEGDIPGITAKMDYLKHLGVDILWISPFFESPQKDNGYDISDFKNVHAPFGTVADVEDLIKGCHDRGMKILFDLVINHTSSEHEWFRQSRSSKTNPYRDYYIWRPAKYIDGVRHPPNNWRAIFGGSCWEWDEGTEEYYLHYYVKEQPDVNWENPKLRQALYDDAIKFWLDKGCDGFRVDTCNKYSKFTDFPDAKVIEPDAPYQNAIKFLTNGPRLHEFLREMHDETYAKYDCMTIGELGSTPLIEDVLKFVAAKERKFNMVIQFELSRLDHGPAGSRFHLMTHEWRLSKFKEITARYQRLTESQFDAWGVTYLENHDQGRSVPRYGSDKPEHRVNSAKMLATFLLTVSGTPIIYQGEEIGMINCPEEWEIEDEYKDVATINQWAEMKATAAATNDTKLLVDGKRGIQQTARDHARTPMQWNDDKNAGFSTAENTWMRAMDSYKEINVAKQQGVDSSPLEHYRRLLALRKEHKDVFVYGHFEPSIDENNDHAYIYLKRSEDRSKKIVVALNFSGQAQTFQAPEGLTLVESLKFEDGGRRGVLGPFEAQLYMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NU37</accession>
    <name>A0A2X0NU37_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">BQ5605_C010g05966 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">BQ5605_C010g05966</name>
        <name evidence="15" type="ORF">BQ5605_C010G05966</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NU37"/>
    <dbReference type="STRING" id="796604.A0A2X0NU37"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000009">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="13">
        <location>
            <begin position="85"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="14">
        <location>
            <begin position="284"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SGY13760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="482" mass="53561" checksum="8F1756C2597294DB" modified="2018-09-12" version="1">MRELITVSVGKFTHARSGSPFDQRLVPHPHVTPLTTDHFPVPRSTPGQAGCQVSEAFWDRILREHGLDQNGMIVAGTEDMQRGRTDVFFSEATDRKYVPRSLIVDLEPGTSDVIKGGPLGNLFGPKSYINGLAGAGNNFAKGFYTEGAELVDQITDELRRQAETTDLLQGFQLVHSIGGGSGSGLGCLIASKMREEYPDRILATYSVLPSPKVSETVVEPYNAVLAFHQLVEHADLTFALDNEALYEIMQKVLRKTDPGYADLNSLIGKVMSGLTTPFRFPGQLNADLRKLATNMVPFPRLHFMLTGFAPITSVGAQAYRKWSVAELTQQLFAPTNMMAATDPRGGRYLTAACYFRGRSVSSRDVDDAMLAVQQRNSDFFVEWIPNAVMTALCSVPPPEQYPMSGTFIGNSTAIQDLFRRTHDLFASMFKRRAFLHWYTGEGMEELEFSEAESNMIDLIGEYQQYQEADVDEEEGAYEEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NX78</accession>
    <name>A0A2X0NX78_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C014g07490 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C014g07490</name>
        <name evidence="2" type="ORF">BQ5605_C014G07490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY18841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NX78"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10098">
        <property type="entry name" value="RAPSYN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14938">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="483"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY18841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="590" mass="64726" checksum="0C71291DC5BD944A" modified="2018-09-12" version="1">MARPLCAALRGSTRSTVTRALDAESQRSQSESVNGSLTLRLQEADHPRPHLRLAATPRQTASTNVKKRTSIAVSPPRKSSPRIKPPSVEEDLSQPVVAPPTERVEPRGPTMTIEPNPSPRSEPRAGPSDEHERRLASLVLKGKKLYKEATLQDISTTEGVSQARRQFLESYEAFKQASEDKKASKAAWKVANLTADLGYRAFKLGDNHGAAKLLLEELRDTDGSVSIQARSIFQRIGDLAKEATCLQQLGLVCIASGDPLQAADYLKNAIVILIETENVPQEASTLCELANLLSSSDPPSAILFYKQALVLFCKLLDSVREARTLYAVAKLYTTEREYATSFAYYLQARVIFRRLGETWIKFVAADADCSYALGKLAAKGELFPAAVSYLEEASLLYRQVSQPVDEAWSLHRLSLVMLRCGDHQLAIDYFLEAQQLFAAEPNQLKAQASCCGRIAQAYRMLKDPVKEYEYTLQASRLHPLQRSTSTKASSNSSGPPAKTHHRNLSTMLPPMEEEIQQVEDNTEFPGVSFSYDSRNAPSSTTAAPQSTHQPNPSASPGVGGKSWWPNSRTIPSSILALSVMASSSTAPRPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NXD5</accession>
    <name>A0A2X0NXD5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C014g07550 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C014g07550</name>
        <name evidence="2" type="ORF">BQ5605_C014G07550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY19063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NXD5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY19063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="274" mass="29339" checksum="48DF27AF0419B553" modified="2018-09-12" version="1">MTTSTSNHFNPNAFSPETLQYRLQLSYLLAPLSKGHFATQPHLIDSQPTTTTPGSSNTKLTCPACQATLIVGVNATVRTHRTGLWWRCLGCKRISKEEGGEGKGIGRERFRSVKQRIKSKRVAVLESGSHNRTKSIEGTSSRKLTKAVSDLPRTNVSGDPMQGLESTTATSQTGFSRAVPAAAPSLASSLTPSKPNFTSKSVALNSEPRVRPSSHTKPTTTTHQNQAKGTNKRSKPTTSGLAELLAVKKLEREKANQAGGASGGMGLQQFLQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P0F9</accession>
    <name>A0A2X0P0F9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C018g08775 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C018g08775</name>
        <name evidence="3" type="ORF">BQ5605_C018G08775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY26761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P0F9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY26761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="346" mass="37172" checksum="9786D0AF725BBEA2" modified="2018-09-12" version="1">MEFKAIVQEIIDTKTNINDVLATLLLAIAHPSLESFKASFTTNSARNEVSPTCEFNSDRSTNIPGTQLALLASLSSRSTRPKCLACCSPSHRVAECPTRAQHPPPGPCRTCKKKDHWSLDCEKALEDGKKPNTADSTVDLPHHVGCLATGLLACCCQLCTNSFVVDLGTTLHMVSDKSLFTTYRHITPTKIGGIAGGINAIGTGNIAFVAALGHPIMLTGVLHTPGLPVNLLSVSHLCNSDNVCVAFTKHGIHIDKDGNNIAEGARLNKGLYLLDADHSKCQHLALLPRSQTSVPLLTLHCYLGHLVLNHMSQEGTGSATSKYTRHNTSCRKYVGVLGERLKRLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P5Q2</accession>
    <name>A0A2X0P5Q2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C005g03293 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C005g03293</name>
        <name evidence="2" type="ORF">BQ5605_C005G03293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY73432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="853"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1070"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="874"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="897"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="964"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1091"/>
            <end position="1102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY73432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1561" mass="172851" checksum="949E25BE4CD075DF" modified="2018-09-12" version="1">MVNSEVSLKPLLATNVPMIFTLLVSINFTETGHCFVSLRDILEEVAELTGLALQEDSCFDYWVVDNAATSSTHSTPCLASCRYDQLAAFTAATDSSDKVLGLTGFVLDIDSLPAEATITLRVYEHIKARLPFVNITTRPKGREDAPVPSGAPSASKHDLLVREKRETSPSDRISGNLRPNTEPYSTDDKLVNSEDHANLPTYSEGRTTMTDLMLEAYPQEIVLDPWRPNGTWGDVLIVRMDPGSSGGLSHMWAFSASSSRTDSKGRWKGPRLDANVEYSKYSKKRCMGVFVCCDQSCPGKRRPHTSLSTASRSKLFQEETPQLVTGRPKKAATRKHLAPNVERPSDELPPCPITSCNGPMRHILCSATIARGQREECPGEIYIWHSGYHLHPPPLVSRPSPQHLEELRQLRKAAPQASAAELRMGQMTAFPQDPRHRPSASEICPVFDSTRSISRYAPRVGHSKRNGALPDTLMSAIEAVANAGCLAYIEIPGQRQGQPLAEQIHDPDPRKQPRNDGSRSKSKITSNSLTDSETSFGIQTPQMKARLSETIDDRLVEGNLGWPTDAHNTYFRDNWVLLATVCYSPSARRWFPILYSVGNHERSGFYRRHFAYLFQILDDANYSVEDIVNGVTFVVDYSSAQISGLRQAISDWYVARKTADVGRLNVTPNQVSQWTAEAIQIGEKAASGCAFHFIEQVRRFGVRHLSTQTERERFAMLVNTMRNAKSHASIESMAKRTIDEFPELNGSAERCVATTTNAVESSHWLLIHSCGGKRFGPVEGVMRLIDFAKMTDRIESHATDGYVRSSTYHEQGNVRAHIKEIKSRNRVPSSYVSDANMPEPSISFAAPARLAGIGFSESPQGPSDLSKGPATPPLSESTKLPPSTSNRSRQQPKNRSRQGNGPTAQSMASKKGSRRVDYPHKRKIPDPPSDEHSSNESSDDVGLTPSIHCNSSEAIPPRDRSIKLHQTSNSKSKGSPPRSDFSGPSRRVPVVPMAVRALNEETELSQILLAQHNARNLEAPSGRKYRIPRKRLAFLLSEPESQSEAKRTCTSVFDIPLSLVASKSELAPSKSARKVEIATPKPASTSTSLERTSDKLPEDSRSAPRVKFAPPKTSTSTSLGSTIVQLHADFWLRSGEDGPVVIIQGPWSDDSCWIDSTLIALLSVANGLGPWLQCLDILNTHTAYVIPPLGDEMVLRLRPRYLALELWDAIREYTALARKFDMKPAANAIEAYTQLRERMISTVVGMSKERGSHFTTPFKRGSYSSPVTWLETLHSFTVDHPVLPSAVTLNDPDRTLVELHLQRAGYCTACNCIQIEVSPRRQFVVDWPLLISSFHLPSHSLETLSDVLASIVGQPLKLYTEAKNSGRRHHKRNCPGGSYVQFVSITSLPRVIVININNIYPEHPLAPAELRFGVSDQMPEMVWRLRSGVYNINNSHFVTNATVGYGQEAACYHFDAIKGSLARPIGDRNAGGLVSVLFYELEEESLNFLQAFNLMLTRQWHEMGSLYHEPSDPTDIGIKVSSLPPKGTLEEGQGVWKMEDASAFFHECEIVSVGNAKKADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P6R4</accession>
    <name>A0A2X0P6R4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00716 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00716</name>
        <name evidence="2" type="ORF">BQ5605_C001G00716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY48931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P6R4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="660"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="727"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="374"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="730"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="788"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="806"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="828"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="863"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="976"/>
            <end position="987"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY48931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1014" mass="104245" checksum="D79768494257D1D4" modified="2018-09-12" version="1">MSPDHALLSPAEVDALPTPHAPGFWPETPAADAYLQNEGPLEQAGRSMGPLHSEETTEEPMRAEHDVLAPAILATGAGLLLGGPVAGVVAGLAAGVAGLERQGLKKGLAHTDTPNEQLGTTQSQDVTPKRSPSSKHTATLVPEDVTEQKTQAALAASPAQQMLGGEDAHQDLSALVAGAAGTAVVDKEIEEPTTDLTEQARDSAVSNVVPDPAWKSNLISTGVQTEESASSTPTKEEGLSSSEKAALGAGAGLGAAGLAAAAAHEHKHHDAFSDSVRPDLATTSEPLTLNEKTPSTVAATPSSEATAQDVKDAEAEDSEKAKEGWTDKEKLAAGAGVVGAGGLAAAAISHEAKQHEKMPIQPVQPVQEPTYAASSSPGQSSSSVQPVQQLSTPATVASNYPSSQETSREIREDPSTAEEPKEGLSDKEKAAFGAGAAGVAAGGLATAAVKDHETASPSPPQGPPLASALPPLAPVKDSTSTGVASVEGPTGLSAQQDGDAVVSSAPLPVANPADPPVGSYVIPKVMDEDRDAATPGKITLLNGEDRTAESNADAAQDGEIKEDPTKDDSHKTELAAAGAALGGVGAIGAYEALKPEHRQVKSRFSNTTLGSNMAPTVHSDEEAHGTFEDQRYVAHDSSLGQDFSHDKVDPASLVTPAAATVPGFTGESSTREDFAHLSQQPEEVAPQEEDRKGWTTGEKLGAGAVGAGGIGLGAAALAHHNARLGEQGTPILTTNNSLQRVLNESSLPGAESSSKPSSTRAMKGSPVGTPGVQERATTPESPSFPRQAAVVGAGAGAGAVAADQYYQPQQGEHLQQGGSPHPGGYPQEGDHRQQAEGDRYRQQGDSYSDSPRGDLTAGSGSTVDRRSGDAQRLHFQDQYPEGMHPVEKSPHMRIATHVDGSGRKKLHRKSLGDVFAPGEGTQFPVQTSPRNASPRVGNGEQGFGGYDDRRDSVMDRVVGIHDPASPSRTSGEHGRTHSKLSKNRRLSRGAGEDSPDGTASPKKSGFFSKMFSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P7G7</accession>
    <name>A0A2X0P7G7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mediator complex subunit 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C008g04984</name>
        <name evidence="6" type="synonym">MED10</name>
        <name evidence="8" type="ORF">BQ5605_C008G04984</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 10 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY78890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P7G7"/>
    <dbReference type="STRING" id="796604.A0A2X0P7G7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019145">
        <property type="entry name" value="Mediator_Med10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09748">
        <property type="entry name" value="Med10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY78890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="200" mass="21555" checksum="A13EDB2902E7026A" modified="2018-09-12" version="1">MTVDALGVSSPDAEHHHSARGHTMAGEGTRPTYAIEQTLEQLLQSLLEMGICASDVQESALSSTPGGVASGYPGGLMGRKVSQTMEQLTKLYSYSGTVQDVMIPLEVVNFVDQGKNPHMYTREFIERVAGENMYTNGMLSAVSDYRDILTSSLGDAFPELVNHIRASPHPAVKQENGTHAMDGNDAQLGSNRETGVKMEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P7L0</accession>
    <name>A0A2X0P7L0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g03772 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g03772</name>
        <name evidence="2" type="ORF">BQ5605_C006G03772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY53547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P7L0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY53547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="401" mass="43299" checksum="E622FF4B554FAA40" modified="2018-09-12" version="1">MSDERASSRPNATTEQVERVATTPADEEVYLRHDSFARSLLPLMQLRGAPADSASATDGQRPATSRVRPLQSLQALRAPVVETASPLASPTHVVVPQRVMGAVGRFDSSFSRATKPESNAPAATRGHASPISSRAGLFQSNALTDRADLRPYAKSMMHGSHIPISGRIPRPPSPTVNWDGEGHDGTLEQWSPRKVKSRALMGFAARATLLFSSTRTANVLWQHSIAHNRTGVGLAQSIQDVARPSLCLRVLSVLPDNDPREMPSSLARPPTTSARIGGKRSVLLHCRLSFTPIHAQSDRYHDATCDIQDGFVLLSVLDSPANSTCVGEIVPLPSDLVGQQTTTTATSNGFVPTGTADLSRIQAGCDVWVLQPYHHVEIVRVDSHSDVKRINLICTRFLVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P7Q3</accession>
    <name>A0A2X0P7Q3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">BQ5605_C006g03901</name>
        <name evidence="22" type="ORF">BQ5605_C006G03901</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY54712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032549">
        <property type="entry name" value="DUF4939"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16297">
        <property type="entry name" value="DUF4939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0229">DNA integration</keyword>
    <keyword evidence="16" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="21">
        <location>
            <begin position="596"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="20">
        <location>
            <begin position="1530"/>
            <end position="1709"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="21">
        <location>
            <begin position="2116"/>
            <end position="2217"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="19">
        <location>
            <begin position="2344"/>
            <end position="2405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1161"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1907"/>
            <end position="1934"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="878"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1161"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1191"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1915"/>
            <end position="1928"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="SGY54712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2414" mass="272225" checksum="60AF2A266A6B607B" modified="2018-09-12" version="1">MAATELQKLKELGPLRHKNSAEWFRRARRLFDTTGTSLHIDFEITKPAKRGEKETEDAFYTRAQRWTKVNSQGLLVIETCVTKDTWVSIGGNTHSSFRQVWDALKKRFDRPAPGFTLEILFSEFCTFDYKPGEDLNDYLDELLDKRREIERMKVSNFRAEMGEDKWNAYNKALPSEAIETTMAIDKFLWKAIILARIPRDIAERVRHLDDNKSFINAARDLWKERLDREKKKASTAKPEQPQVFSITPGCVPGCRCPSCQPDLYPKVLAAQAVQPLAAKKKSQAKGASDYQNYEKWTTLGGRIVNNKFVCGYNQCWNCWGAGHLKQACPHLATIDCELLRDRTLRSLGITIGSRNQAALFVEFEGPGVATSVIGHGHFVTAYGASNNPEDERIDNTELIYDTAATCSISPHRHHFSSYVPALLKAYVKDAGGHLHLIAGSGTVSPQFVLDSGSIKTSDIYNVLHVPTMVATLISGPKLYDRGLHSSCDGKVFCLILDGQTVAICDVGDRMVFKARRISPNVTDSAYALMSHPSFADLFTWHERVGHVGAAALKKMEKEGLAWGLRILSGGRSVDSCEACGLGRGAHTSVPKIATIQEAVPLRKLFTDVWGPVKYPSLAGHTYLLSIIDDASRFHWIFPLKHKSKVTQHIIDFIERVERERDLPVVKIQSDGGGEYVNGALKAHLAARGIEHIVTVPYKHLQQGIVEQYWRTLFEGVRSCLAHSNLPTSYWCDAAQAFACVSNRRSSRANAGGKSPYKLYHGRIPDVHRFWVWGCCHESAVRGLSAAPPRSLLSAGNFLGASSYLYDLAPRSLPLASTCFHEFLSLSLGFPSTINRAFYSYKNNYINPASRPVILAIACCLRLSNLNPDSRSRFPIDLVDLTQASLDSLIDQLRTLQARNQALEAECRSHLSDKENYQITVTALANQQQTLSDFVKAVVDQQKESIDVIKSGLANLNVTAPANTTITPVKSQLAKPDKYDGKEKVKFKTFITQIKFYIFGNPSSFPTDESKIAFIISHLTGDAFQHFEHAINAKDDSKPEWLTNYQKFLDQAELVLGDPDYRNNLTRQLMSLVQSGPASVYASKFTQISSQLDWNQAALIAHFHKGLKLDLQAQLALHDDPQDLQSLIELAIKVDNKLHLARHRTNASTQFRQTNWQYSHSVNSPLRTSPVSQLQANPSTANTSGPAPMDLDATHSRRGPLSEEEKLRRRTNRPCMWCASDQHLRAQCPTAPPMIPRHTALNASPRMSCTGTLFPQVSSPPSPRYSQQNSTRFPKTTLFCPSYSISSPHPDLATSFVHDNHLQLIAHPTPIPLYVIDGRPIQSGNITHFVHLEVQFNGHTQSLRADVTQLGTYPLVLGMPWLRLHNPIIDWKRNTLVYSCQSCALGHTQPINVSIEGAPLVPLDHKHLDISFASSFAFERLVNNSDNHHGLLFYDPASHQLSSSIPAPSQSLSDDNQDSLEYLESLKNLVPPEYHHLLAAFSKVKADQLPPHRKFDLSIDLEDNTTPPFGPLYPLSETELQTLSSWLKENLSKNFIRASTSPAGAPVLFVRKKDGSLRLCVDYRGLNKITRKNRYPLPLIPEALDRIRGAKIYTKLDLRSGYNLVRIKEGDEWKTAFRTRYGHFECLVMPFGLTNAPAAFQHLMNSIFRDLLDVSVLVYLDDILIFSGDECQHTRHVQEVLQRLINNKLYCNPKKCEFNRASTEYLGFIISPSGVSMSQDKVKAITSWPTPTSLKELQQFLGFCNFYRRFIEGYSRVIAPLTRLLKKNAPFLLDSAALSSLDRLKQIFTSGAILCHFNPLLPSIIETDASDFAISGILSQVTDGHLRPVAFMSRKMLPAEQNYEIHDKELLAIVECIKIWRHYLEGSQHPFKIYTDHAALQYFQTKRVLTRRQARWSETVNHHKYTIGYRSGSKNNKADTLSRRPDFSEGGKASEQPGQILLRPHTLAASLVKFSPPSDIADLIKFHLSQDPVSNQIVNDLNHDSTLHPYFKLQDNLLLHHDKIYIPNAEPLKVKLLAQAHDSLLSGHPGQVKTFVFLDRNYTWPGMRQFVNNYVKTCDSCQRNKPTHHRKHGHLQPLPIPSKPWSSLSMDHIVDLPPSPGFDYRLISRPGSDVPHVFKLHGLPTDIVSDRGATFTSNWWSEFLAMLKIKPNLSTAFHPKSDGQTERTNQTLEHYLRHFCDYLQTNWSELLPLAKFAYNNSFHSSIGASPFYVTRGYHPRLEVSLRDSFVTDVPKYLQHLRSVQEAARKQILQAQETQARFANLKRKPSPPFKIGDQLDSHKLGPFRIQRIISPAAFKLEQLPASMKIHPVFHVSLLEPYQANSLASRCSNPPPPPEIINGEEEYQVKQILDSRNNHRSRHLEYFVDWTGYGPQDRQWVSAADFDDDDSLVIEFHTRHPHKPGFERIQGLNGARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P8D7</accession>
    <name>A0A2X0P8D7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C006g04112 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C006g04112</name>
        <name evidence="8" type="ORF">BQ5605_C006G04112</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="4">Weakly associates with the stable SPT16-POB3 heterodimer to form the FACT complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NHP6 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY56171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P8D7"/>
    <dbReference type="STRING" id="796604.A0A2X0P8D7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01390">
        <property type="entry name" value="HMG-box_NHP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000016">
        <property type="entry name" value="FACT complex subunit SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00886">
        <property type="entry name" value="HIGHMOBLTY12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="7">
        <location>
            <begin position="26"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="5">
        <location>
            <begin position="26"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00064996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY56171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="97" mass="11091" checksum="94FCCC1BC3EFE3EB" modified="2018-09-12" version="1">MPKEVKSRATKVDTKSGKAKKDPNAPKRPLSAYMYFSQENRNTVKDDNPDASFGDLGKLLGAKWKDMSDEQKKSYIQKAEVDKNRYEREKASYDARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P9G4</accession>
    <name>A0A2X0P9G4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C007g04553 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C007g04553</name>
        <name evidence="3" type="ORF">BQ5605_C007G04553</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY61371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P9G4"/>
    <dbReference type="STRING" id="796604.A0A2X0P9G4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017125">
        <property type="term" value="F:deoxycytidyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="131"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY61371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="386" mass="42251" checksum="38EEA3A976AF6B7B" modified="2018-09-12" version="1">MDAYLTKSKASLAVNKSSSTRKKRPKQRQLEGRPTVASNAAAQATTSTPTAKAGSIQSNALLAGGIKATNAPLLKQLGTDESAITNSTAYSRTLHIQSVASGHQSGGGGPGGSTKWRVHRNTKLKNQAPDAESDLFKGLVFYINGLTGKSITNQQLKRLIYENGGTMKYEYLHILLPSLALTNQIPHPNHTNRLIESAAVTHAFVSNLSGSKLQRVLTKKCNRIKYVTVQWAIESVRCGKRLREADYAAPIFAETQSSVMDYYANEDSRTIILDDDGEIELKRSKETKKSIPRRSLNHPSAFETCHDLPPPSAAPTEALPRLPPPKGLIKEKDRDKVETVVLSSSSPWVIENAQPGRLDLGEESEEEEEDALDEWGMPPSAQKCRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PA91</accession>
    <name>A0A2X0PA91_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C037g11614 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C037g11614</name>
        <name evidence="2" type="ORF">BQ5605_C037G11614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000062">
        <property type="protein sequence ID" value="SGY93860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PA91"/>
    <dbReference type="STRING" id="796604.A0A2X0PA91"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY93860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="107" mass="11453" checksum="F939508ACD6F30EC" modified="2018-09-12" version="1">MSSWAKAFDAQWKMTMDKVMGTEAENAPADWAQSMAGYSIFATRKESAAAPRLLAMLNGNETSSDNSTSFTSNSTTPSKYSTAPSGTRIRRKNVRGESGSPTTASES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PBS8</accession>
    <name>A0A2X0PBS8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C032g11103</name>
        <name evidence="14" type="ORF">BQ5605_C032G11103</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000067">
        <property type="protein sequence ID" value="SGZ04989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PBS8"/>
    <dbReference type="STRING" id="796604.A0A2X0PBS8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026895">
        <property type="entry name" value="EMC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011678">
        <property type="entry name" value="EMC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_b-propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_rpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07774">
        <property type="entry name" value="EMC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016039783" description="ER membrane protein complex subunit 1" evidence="11">
        <location>
            <begin position="24"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrrolo-quinoline quinone repeat" evidence="13">
        <location>
            <begin position="73"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 1 C-terminal" evidence="12">
        <location>
            <begin position="709"/>
            <end position="914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGZ04989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="926" mass="101562" checksum="4A9C1575F33BEE4C" modified="2018-09-12" version="1">MWPRVRWMLPLLLTVLHSTAARALGSPDWHRVQIGLPRERVDFTAEPLHQFRHVASHDESSRKRSILLTVTNKNILAALDPANGTLRWRRLYGPHAHKLSYFACGDDSLVVSSRADLGDLQVVDATTGELRWASPTSGADDFVLGPAQLAGDAICWGDHDGFNRTLVSYARGILRSRDVDTGAEGWHVEVAGWDPADRVRLARSQANQIFVFAWPKRELTMGSLRIYNASTGNLLRDTMRVELPTLADHMPLAVSSSSDKSDSGALVWVGGSSVRWFALASSSSGVLALADGTSSDFVSVGNVGLAGRGIFLAHRRDGTVVVLRWTGVSLTKLWDLNDSSFASLFSGFVDREDEAHIGHLSFSPTLQLASVQIFSLVVIPGSPQGVITGHTFKFDPEDVGDLLSFAIETAPLRDYSVASRISFASTSGLLQVRENEHFAWARDEALAEIDHLPAMVQISDGFSGARTSPITRLLRYGANGKVATTSLAVVVSSRSQTIHGLDAKDNGKVVWRYFVSLEGRIEWETILLAHLDGTGTTSSVRVNATARTSDHRLLLISLDAQTGQELDHQITEDRRPPRHHQGSTSSLFFRGVNPGCASKIKAGDGLVEGWSMCDRQRRLSWRYKLPAGHTVVRVVRGMLDAVASPGRALGDRSMLLKYLNHGVVAVVAISKSTSQLTLSILDAASGRCLHEALHDGVRTSKDISVSMRDNWIIYTLYAEGDPSTFTRVHSLELFHQTSSFAIEAGSSLSSLRPDLASISVSSKSFLSTDGLRVRGLTRTRLGITSLSAVFANSMNQVIALPRRHLDPRRHTRQPTREDLEELLIPYEAILPNNPRWVLSRAYELSDVQLMLSYPGDRESESSILAIGADLFGARISPSKSFDVLSPSFNKIQLGVTLSILAITTIVSRHWVHVRLIRCNALHFELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PCI6</accession>
    <name>A0A2X0PCI6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C005g03317 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C005g03317</name>
        <name evidence="2" type="ORF">BQ5605_C005G03317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY73770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PCI6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY73770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="348" mass="40267" checksum="062BE2C1477B4BD3" modified="2018-09-12" version="1">MDEGLTKAFTPFSSQRPTVPISLPLLAPHHPKPTMFRATFRRLASHTKCPVHTDCRPNLHNVAPPIPYLDTEPSLPTTKVNFKGHPLPPPRTSISYALARGDEDVFVRYLRNGNWPHKPNFGALHLKFPRVRSLVTRVVEYNQFDVVKEKVDEETGETIKFTWPAGTLETIYESFVVDQNTYDRESRIALQNHQVLDPRTQILENLVNVNYTYLSTNEKDGFPEIGEGFKGRVGTYWDHCESFLKTERAFGEELEERRRYMERKRVAREADDAREAKEAEENDEDDEEDEDEEGEEDEEDAEGEESDEEEVESEEDKVREEIMEKVIKEVLDNVARQTQGRRGGSWKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PDU6</accession>
    <name>A0A2X0PDU6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C008g04918 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C008g04918</name>
        <name evidence="5" type="ORF">BQ5605_C008G04918</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY78704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PDU6"/>
    <dbReference type="STRING" id="796604.A0A2X0PDU6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="50"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY78704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="130" mass="14281" checksum="B72E51CA5319B2C1" modified="2018-09-12" version="1">MPKHDPSKAAYTESLATHAPIKSNHLPTPTYRTQAAVSPPHRTVPLNAASGLGRARALYDYEGAEEEDLQISEGEVVTVVEHGESFSGSKMFACTQIHRLAFATVSDEWWKCQAEDGRKGIVPRAYLETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PES5</accession>
    <name>A0A2X0PES5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C008g05278 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C008g05278</name>
        <name evidence="2" type="ORF">BQ5605_C008G05278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PES5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY79997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="71" mass="7594" checksum="8A840B49029DFBA6" modified="2018-09-12" version="1">MASPAAPASSAANGHSGQQHGVDTHSTRVDVINTQGGKILCVSDIRALSHNRERMDAHCSYRPSRSSGWQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PGK9</accession>
    <name>A0A2X0PGK9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C027g10319 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C027g10319</name>
        <name evidence="2" type="ORF">BQ5605_C027G10319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PGK9"/>
    <dbReference type="STRING" id="796604.A0A2X0PGK9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ28353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="134" mass="13066" checksum="4F5AA005C82FB60E" modified="2018-09-12" version="1">MTTPAQHLQHAAAMAAANTGMFGMALPSSSSGSVPSAAATASTSAAHGNSSTGDGGGQSAPPPAVPLSGPSTSTSHPVGAAPSPQSGAGQRRTPLKAQAPNKASASNNNKDKGDKKTRSRLACESSRLDRGPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PGN3</accession>
    <name>A0A2X0PGN3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C027g10349 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C027g10349</name>
        <name evidence="1" type="ORF">BQ5605_C027G10349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PGN3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ28477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="117" mass="13067" checksum="E9D7A358F4429BAA" modified="2018-09-12" version="1">MFKICLDNISSNCGLADCARHDCVGIASTAQFIRAYPNSVWFLPICDENHWFLGRIDVKHGAWSIHNSLASRKLTVAALNALEALLKVLNLIIRAKAFDPTHAALSRIRQFCRAIDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PI73</accession>
    <name>A0A2X0PI73_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C030g10775 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C030g10775</name>
        <name evidence="2" type="ORF">BQ5605_C030G10775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000069">
        <property type="protein sequence ID" value="SGZ08171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PI73"/>
    <dbReference type="STRING" id="796604.A0A2X0PI73"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052925">
        <property type="entry name" value="Phage_Integrase-like_Recomb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34605:SF3">
        <property type="entry name" value="P CELL-TYPE AGGLUTINATION PROTEIN MAP4-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34605">
        <property type="entry name" value="PHAGE_INTEGRASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ08171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="103" mass="11796" checksum="AA383FC3DFD253F7" modified="2018-09-12" version="1">MRHAGRLFSYRAREGSHRQLTSSAFLRRIKHILEASGRAVLNNHSFRSGGATFYLREGVHTDHVRNLGRWSSNALDRYWRQHKEIAIQVLSKAGKLALDSGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PM43</accession>
    <name>A0A2X0PM43_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C024g09860 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C024g09860</name>
        <name evidence="2" type="ORF">BQ5605_C024G09860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ26212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PM43"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="384"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="602"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ26212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="749" mass="79697" checksum="540E9DEDDBD8F186" modified="2018-09-12" version="1">MPAAGETPTASVSAAPPTPLAPSQWSTAASCSSPLSTIPIMMPLSDGSTHHYRPCSRESNSSCDSFSSSFDDYGVDAFSESGFGALGATTTTSFGFGGGAMASGAGASGAGTSAALEPCINGSGFMVRTHLDDAHDFMIEVTWSELIGLLVDPSISRNLGPAHLVSKIVTFVRGKFESTDSAELGHSDTSSSPFLYQARASSMQPSMHGDLSSINSVANDMELLAVRPHDIFPSNVGSTEDLNQVKDVLVNSLHPLTTSTSSYVTEGYGSGTDAGLESASWTNQSKWRGPSNIHPGPAHPKQHDISTTVQYARSSHPYSAGPNELLELPTSRPGQSYLSNELQGMQLQPRSGPARPEPRSRHSSDAHSMQRAMYRDQGRPYSRSGSGLPTSLPPSGGHSIRSAKSEKGEHEGSSSHHDSRPLQPLNGRTELYVFDDLSQTVARVSHGAEALSPDAALIEFPPGSYHRVFHEDLEVLPSDIGHGRAVLWLRGQVCVAKCRFRLEGKVSRHMPIVWTGRYERDVKNNPHFFKQRPAVIRAHFATCKLREGLSVDPLGRLCRLQVEARRWATERDRERLANSAASIRSLPDSSNCDSDDSRSVRSEYSIQSTGSSVTSFSASHPSAQPTVLGPVRPIRSRQHPDGRPLAIIAGAGSKDGDGPYGSGDRPMVLDDEAAVGSEDAAYALASGGTANQGGHWTDQWLDQHASSDVMNGDALRTATLPRAGALRSTRSMAQAAAAGTGGASFLSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PNM4</accession>
    <name>A0A2X0PNM4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Non-structural maintenance of chromosomes element 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C046g12270</name>
        <name evidence="11" type="ORF">BQ5605_C046G12270</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the SMC5-SMC6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NSE4 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000112">
        <property type="protein sequence ID" value="SGZ30915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PNM4"/>
    <dbReference type="STRING" id="796604.A0A2X0PNM4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027786">
        <property type="entry name" value="Nse4/EID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014854">
        <property type="entry name" value="Nse4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029225">
        <property type="entry name" value="Nse4_Nse3-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15412">
        <property type="entry name" value="Nse4-Nse3_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08743">
        <property type="entry name" value="Nse4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nse4/EID protein Nse3/MAGE-binding" evidence="10">
        <location>
            <begin position="106"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Non-structural maintenance of chromosome element 4 C-terminal" evidence="9">
        <location>
            <begin position="268"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF15412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGZ30915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="374" mass="41704" checksum="C620AD49E94E9BDF" modified="2018-09-12" version="1">MMRDDDDHEPTSQLNGNANANGNAHHGDEDPADDDLDDLAPAGESTAEQRRARERQLRAHYRSLGQSVQESRDNINETTVDSLGKQVERANKLFRNVTAPSEAVLDSRVLMAASDAGALKARQLKLDADAFDTDQFLVKLAHFMGGSVMTLNQKNKGKGRSQTQDDDKAATEGAGRTLRWGRVGRVLASESRRAVVMDLMLGPLALEVKEKKARTQRARQKVDESQRVRPEEVTTESLAWYASRSSPLVGRTVLQIARILDAYGGEGIPYLSFVLNPHSFAQSVENIFYFSFLVRDGRACIEEEINEDSKHFGEIICYSCEAPDGNTDAEGSKSQFVFELTQELWKDAIEVFDVQTSAIPHRAKFQEQTNAKWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PNS0</accession>
    <name>A0A2X0PNS0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C054g12628 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C054g12628</name>
        <name evidence="2" type="ORF">BQ5605_C054G12628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000093">
        <property type="protein sequence ID" value="SGZ29355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PNS0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ29355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1110" mass="126110" checksum="3185D0CCFF833534" modified="2018-09-12" version="1">MIKHTIITWNVRRGMGVPEKRRDIYNYLSLFKASAILIQEHFIRPHLWQLIKDKYEGKLFINQHCLTLIPADSPLIDAELLRTHSALDGRLLVTSFRLRGDIKILEINNVYAPVDPKQQAKFFDKLLFHKTQKSHLRLLGGDLNDCPRPEVDRRNQSRRGHHWPILIGKLDSAYMDCIRYKHPITPSFTRPNPNRKRPNSFSRLDYFLLQRTHQKRLDQASTIYDYPKELSDHQPVLIVLALSDDPDATLPQLSLPTTSNQLHRINTTTFKTVEFQRMMEGWLEGASGEEPVGELEEAASERTERMEYLVGRVQDLEAIPEWGEAETAEWTRTSEELKRAVEERACLLRIRAHVPKIASEERLSRPVHAKLAARNSDSKITALRLSNGEITHDIDVALDHTQAHFQRLYHIEPCDPDRIDRLRDEFLAPIRAARTCDDPRSDPLFLRRLSESQIDLLQQPITEDEVTAPKVWAKVLTKAYNAMIEQGSLSPKQGQGLVRLIFKRHKKNADRAELSSYRPITLRECDYKIFTKVYVARLNQILPDLLPSQQHGFVKDHRLADAALHLRLLIEEHDWIFAIFDALGAPATFLCVLRMLYSGDSTSARYIINGFLTAPVRLTCGLGQGDPASSSVWDIHATNGRLNTDKTVVLPIGRRWDPGQRPLVVKAAGESLEWIGLPFDPSGDTELAYANLIEHLEATLEGILHFLAADIPPPEVVKKLDDMLVDFVPQGGLGVIRMQDVVDAVAARIWDVLLGALGVPKQQDAQVNPRTLTTANLLALPTLLGSLHTPIRGRQTIDAVHIPDYLRLQGYPKVADLYRRKLYAGGGFHLWTPPADVLGDNSEYNRRGLPQRLAIAAWYRFTVDRHKNTPLAVAMAAGRLNPVARFAMEQRLPDPVLPQQASQYKLLNMARPYTIRRIRRVLNAKAFTNTLGLKGPPQPDDLRSFWKAVNSKALTAREREVWFKLILRFTPTRKLQHQQNHDTSPACLVCEAPVDDTNHYFFDCVDSGNVWIAARSVLCDALGLDTIDNTHYTAVQRMFGLPKLKASLRDQEGAGRMIEIITGLVLEMISSGRWGMQKWGTRMEGVGRRRIILEERLKLRAGGAWGRRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PPN9</accession>
    <name>A0A2X0PPN9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="21">BQ5605_C076g12933 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">BQ5605_C076g12933</name>
        <name evidence="21" type="ORF">BQ5605_C076G12933</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000127">
        <property type="protein sequence ID" value="SGZ34649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032549">
        <property type="entry name" value="DUF4939"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16297">
        <property type="entry name" value="DUF4939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0229">DNA integration</keyword>
    <keyword evidence="15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="12" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="19">
        <location>
            <begin position="652"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="20">
        <location>
            <begin position="1201"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="18">
        <location>
            <begin position="1502"/>
            <end position="1563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="287"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1035"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="315"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1037"/>
            <end position="1050"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="SGZ34649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1572" mass="178591" checksum="AD41D9E350B9B432" modified="2018-09-12" version="1">MEDLTQASLDSLIDQLRTLQARNQALEAECRSHLSDKENYQITVTALANQQQTLSNFAKAVVDQQKESIDVIKSGLANLNVTAPANTTITPVKSQLAKPDKYDGKEKVEFKTFITQIKFYIFGNPSSFPTDESKIAFIISHLTGDAFQHFEHAINAKDDSKPEWLTNYQKFLDQAELVLGDPDYRNNLTRQLMSLVQSGPASVYASKFTQISSQLDWNQAALIAHFHKGLKLDLQAQLALHDDPQDLQSLIELAIKVDNKLHLARHRTNASTQFRQTNWQYSHSVNSPLRTSPVSQLQANPSTVNTSGPAPMDLDATRSRRGPLSEEEKLRRRTNRLCMWCASDQHLRAQCPTAPPMIPRHTALNASPRMSCTGTLFPQVSSPPSPRYSQQNSTRFPKTTLFCPSYSISSPHPDLATSFVHDNHLQLIAHPTPIPLYVIDGRPIQSGNITHFVHLEVQFNGHTQSLRADVTQLGTYLLDSEPLRLHNPIIDWKRNTLVYSCQSCALGHTQPINVSIEGAPLVPLDHKHLDISFASSFAFERLVNNSDNHHGLLFYDPASHQLSSSIPTPSQSLSDDNQDSLEYLESLKNLVPPEYHHLLAAFSKVKADQLPPHRKFDLSIDLEDNTTPPFGPLYPLSETELQTLSSWLKENLSKNFICASTSPAGAPVLFVRKKDGSLRLCVDYRGLNKITRKNRYPLPLIPEALDRIRGAKIYTKLDLRSGYNLVRIKEGDEWKTAFRTRYGHFECLVMPFGLTNAPAAFQHLMNSIFRDLLDVSVLVYLDDILIFSGDECQHTRHVQEVLQRLINNKLYCNPKKCEFNRASTEYLGFIISPSGVSMSQDKVKAITSWPTPTSLKELQQFLGFCNFYRRFIEGYSRVIAPLTRLLKKNTPFLLDSAALSSLDRLKQIFTSGAILCHFNPLLPSIIETDASDFAISGILSQVTDGHLRPVAFMSRKMLPAEQNYEIHDKELLAIVECIKIWRHYLEGSQHPFKIYTDHAALQYFQTKRVLTRWQARWSETVNHHKYTIEYRSGSKNNKADTLSRRPDFSEGGKASEQPGQILLRPHTLAASLVKFSPPSDIADLIKFHLSQDPVSNQIVNDLNHDSTLHPYFKLQDNLLLHHDKIYIPNAEPLKVKLLAQAHDSLLSGHPGQVKTFELLDRNYTWPGMRQFVNNYVKTCDSCQRNKPTHHRKHGHLQPLPIPSKPWSSLSMDHIVDLPPSSVFDCVLVVVDRLTKEAHFIPTHKTDSSRDLARTFLTHVFKLHGLPTDIVSDRGATFTSNWWSEFLAMLKIKPNLSTAFHPESDGQTERTNQTLEHYLRHFCDYLQTNWSELLPLAEFAYNNSFHSSIGASPFYVTRGYHPRLEVSLRDSFVTDVPKYLQHLRSVQETARKQILQAQETQARFANLKRKPSPPFKIGDQVLLNQKKNQTSRPSSKLDSHKLGPFRIQRIISPAAFKLELPASMKIHPVFHVSLLEPYQANSLASRCSNPPPPPEIINGEEEYQVEQILDSRNNRRSRRLEYFVDWTGYGPQDRQWVSAADFDDDDSLVIEFHTRHPHKPGFERIQGLNGARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LPX0</accession>
    <name>A0A2X0LPX0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-mRNA-splicing factor CWC24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C010g05880</name>
        <name evidence="9" type="ORF">BQ5605_C010G05880</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the CWC24 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LPX0"/>
    <dbReference type="STRING" id="796604.A0A2X0LPX0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034247">
        <property type="term" value="P:snoRNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16539">
        <property type="entry name" value="RING-HC_RNF113A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039971">
        <property type="entry name" value="CWC24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930:SF0">
        <property type="entry name" value="RING FINGER PROTEIN 113B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930">
        <property type="entry name" value="ZINC FINGER PROTEIN 183"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="4 5 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="183"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="183"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="324"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY13511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="382" mass="42188" checksum="9DD6EB90D1400D27" modified="2018-09-12" version="1">MSDEAPIKFIKKRKGAPTGLRQKEAVASTSTAAAPSTSTANGEGEAPVESEVIHATKRHLTSHLVQGTAGAIRKRKEKDAFADLSDEDEEAAEAERTRQTVGVRYSATTKRERRRSSSPPAEVSAELIKLQQQSKGKDGDRSARDVPDDGLYRGAKATQHQVTKSFGPIKGGPDNVRQITLVDYQPDVCKDYKETGFCGFGDSCKFLHDRGDYLHGWQLDNSFLSSSAAAGSFLSKQHARDNPDENDEQEPVDDLPFACLICRQPFGKDPVVTLCGHYFDAACAIKRFAKTGKCFACGTSTNGVFNRATKLIDKIKEREKLLEEAKEQEKEFEDDEGGIEIEGLEEEAGGASRARQEKEEEEVYEDEEPRPAKKRRPIIQIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LQT6</accession>
    <name>A0A2X0LQT6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C010g06173 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C010g06173</name>
        <name evidence="2" type="ORF">BQ5605_C010G06173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LQT6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016055956" evidence="1">
        <location>
            <begin position="23"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY14404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="181" mass="19767" checksum="F23A334ADA84D738" modified="2018-09-12" version="1">MHLFLLPLQALALGLLSTLVVATNVPLADDLAQVPKHYVCKNTGGLGILYAPNAANDRFEFQGKFHLKYADKTPYGPQGRSWSVSVDIDRTDLLKSRNIANYLTAATVSGTTNNYFRLNPSDLLTSEEIANSQKSIPQNVSLTLQIRKTPTMSQHQKPKLGLSIITASCTFVAHVPFGIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LSY4</accession>
    <name>A0A2X0LSY4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C096g13089 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C096g13089</name>
        <name evidence="2" type="ORF">BQ5605_C096G13089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000010">
        <property type="protein sequence ID" value="SGY11625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LSY4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY11625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="291" mass="32314" checksum="046786B733D479F4" modified="2018-09-12" version="1">MVGFTDLPSELVLHIIDLAEASFVDNETFPISDGRKATLLRFSRVSRAWRAPSQMALHRRVFLQNDADVNCFLACPIAGRYPTRYLQLTHVSPTRINLVLDQLVVRDTNRIALHGLTLIEVSEFHTWSLCHPALRDLKSLQIDGHGRGLMGRLPRDLLNLPHLHSLGFVTSIRAINPEHIRVDCGLQTEELSPVYPGPGTPSLWAELDLVAPRLLSVSFQGLSDALTKPCKRFLAKCSNLVELELDGTALIVPTLCALSPDARLRRLAVGQHNHDTQKDLDPGQAPRPFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LT93</accession>
    <name>A0A2X0LT93_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C011g06340 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C011g06340</name>
        <name evidence="2" type="ORF">BQ5605_C011G06340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY11964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LT93"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY11964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="114" mass="12423" checksum="3D82A64AE15E730B" modified="2018-09-12" version="1">MIGRVQSKPPKRYTPKEEKDGPSLCVVGQETKGAEHVGHLPDEPVLLEKLPNDDGIDLPVSLIERQPIASELWTRINATESGRAECEDIPALEQDTTAIGADDVDNFVSTIAFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LTF3</accession>
    <name>A0A2X0LTF3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U6 snRNA phosphodiesterase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">3'-5' RNA exonuclease USB1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C015g07843</name>
        <name evidence="7" type="ORF">BQ5605_C015G07843</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LTF3"/>
    <dbReference type="STRING" id="796604.A0A2X0LTF3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034477">
        <property type="term" value="P:U6 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027521">
        <property type="entry name" value="Usb1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13522">
        <property type="entry name" value="U6 SNRNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13522:SF3">
        <property type="entry name" value="U6 SNRNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09749">
        <property type="entry name" value="HVSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY17638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="310" mass="34856" checksum="F120BA39276519D5" modified="2018-09-12" version="1">MAIKRLDLEALTLVAVHVGHELGCCKSTLDRKLPRIDFDDEPKDKLSRTSVDPVTLIESDETTALRTRIHPHVPGQWPSHVFITIQATEPLKRIIQRCIARSRILVTAEAASTESAASRESIVPLFSESHLADKYGQSASSSAQKEEKKQDELHLSLSRPLMLMTNQRQALLDGVRKAAQVIEPFQARYANFAVLENDQCTTRFLSIEIGNGWDQMNRLTRLIDQTVISLRLEPYYSQPRFHTSIAWTALTSSRRSDQDTLGTAILPFDDEAVQHMNDELGRELRTIPIDVKQIDVKIGPKTTTFELGCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LU18</accession>
    <name>A0A2X0LU18_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit 5, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C010g06178</name>
        <name evidence="9" type="ORF">BQ5605_C010G06178</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase delta chain family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LU18"/>
    <dbReference type="STRING" id="796604.A0A2X0LU18"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.20">
        <property type="entry name" value="N-terminal domain of the delta subunit of the F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026015">
        <property type="entry name" value="ATP_synth_OSCP/delta_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01145">
        <property type="entry name" value="ATP_synt_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11910">
        <property type="entry name" value="ATP SYNTHASE DELTA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00125">
        <property type="entry name" value="ATPASEDELTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47928">
        <property type="entry name" value="N-terminal domain of the delta subunit of the F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY14423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="247" mass="26492" checksum="50401C852B875B33" modified="2018-09-12" version="1">MGNCRPLAGEGKARADWFAPYSQRSIVCPTPPTHSLLSSVIMFARQVARQVRTYATSASTLHGLSGKYAGALFTAAAKKGGDALKKVQGDLEAVHKTITAEPTIQDFLSNPVLSSADKSKGIDELLKRSKATGSDLTKNFFEVLAENGRLYQADKTIADFLEIMSAHRGEVKVTITTAQPLERDLQKRLEDSLKQSSLAGSGKTLVIENKVNEAVLGGLIVDFDGKSVDLSVASKVNKLNATLQESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LUG3</accession>
    <name>A0A2X0LUG3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Inactive metallocarboxypeptidase ECM14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Inactive metallocarboxypeptidase ecm14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">BQ5605_C010g06019</name>
        <name evidence="20" type="ORF">BQ5605_C010G06019</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Inactive carboxypeptidase that may play a role in cell wall organization and biogenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LUG3"/>
    <dbReference type="STRING" id="796604.A0A2X0LUG3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000084">
        <property type="entry name" value="Carboxypeptidase B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF147">
        <property type="entry name" value="INACTIVE METALLOCARBOXYPEPTIDASE ECM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 18" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016039191" description="Inactive metallocarboxypeptidase ECM14" evidence="18">
        <location>
            <begin position="20"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="19">
        <location>
            <begin position="171"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="16">
        <location>
            <position position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00026213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="SGY13991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="540" mass="59898" checksum="7C7634607BF4194D" modified="2018-09-12" version="1">MRLWAILYLASISSPALFAQTSFAQQQIPLQAPFSAPSTSSSTSGEANVLHRLTFPSRAATQAARDWLQHDYDVWKATPSTIDVLLPMWTDRSVSVPFESWLLDLGATSSSIIIPSLSHLLRTSPTLGSSYNRMLSSAALANWTSSSEASATQSGASQQRRALDASTIHDSYHPLEAIENILRSFEQDFPGFAKVVVIGASSEGRTIWGLKGTFGQQIFTSPTVNIELNLLYYHTVTNFAYQPESAPLNSEQTTMDELLNKRKNKKKKKKEDERLAAKHGFVVVGAQHAREWIAPATALYAIHDLLLSASSDKASDNTRQLLDEIEFTFIPVLNVDGYAYTWTNNRLWRKNRQPVGSDCFGLDLNRNWPYAFSSPRPNPCSEAYPGSEPFQSPELQALSAYLTHEKHNIKAFLDLHSFGQFILFPYSYSCDHASPDQENHFEAVVGAQKALRAVHGRSFDVGSVCEVSLTAPGGSLDWSYQTAGIRWSFSIELRDQGVFGFLLPPSQIRASGEETAEAFKDLAAYVIRKEAGGRFSFDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LV98</accession>
    <name>A0A2X0LV98_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C016g08115</name>
        <name evidence="13" type="ORF">BQ5605_C016G08115</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate = an alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31307"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="Rhea" id="RHEA-COMP:19521"/>
            <dbReference type="Rhea" id="RHEA-COMP:19522"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:132521"/>
            <dbReference type="ChEBI" id="CHEBI:132522"/>
            <dbReference type="EC" id="2.4.1.265"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:31308"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY20657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LV98"/>
    <dbReference type="STRING" id="796604.A0A2X0LV98"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042283">
        <property type="term" value="F:dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF2">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE GLC1MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="578"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGY20657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="606" mass="67520" checksum="002457E6A95FA96A" modified="2018-09-12" version="1">MSTRSRKSRAPRDLPPPLPPTPSHFKAESNTGTGMNMNGSKSPVSSPPPGNVQGQRWWRLSSSERDVLLVSLLVKLLLFPAYRSTDFEVHRNWVHSVRLAITHSLPLSKWYYDTTSIWTLDYPPLFAYFERFLAFFAYIVDPQIVRLDNLEYAAWSVVAFQRTTVVLSELVLATALLMWSRRSKKPDHTTAFLIAASVLLHPGLIIVDHIHFQYNGFLLGILLWSVVAARENNLYLSAALFAVLLNFKHIFIYLAPPYFVFLLRRHCFSSGRQYCALIGFLSDRLVELGALVTAVFAVSFGPFLLAGGPSAIRQIFSRLFPFQRGLNHAYWAGNVWAIVSTVDRVLVKYLLKRGWPISPDAIASASRGIVGETTFGVLPTVTPGLCFTITLSFSMIYLAKLWVDPTYKRFLDSLVLSAFTSFLWGWHVHEKAVLLFLVPLSLTAAEDEHHLRAFIVATTAGVYSLFPLLIKPNETPVKVLYSLLWAAIVFPAVRKVVYRPLPNLMSVLIHYGELLYLAGFAVLHLCNAPSASSAAAQIVTSLPTHIVNGTAMLCGSPGGPACAAEPLAKVAAESTMEFLPLMLTSLYCSVGIIWAWLRLSVIYLWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LWW0</accession>
    <name>A0A2X0LWW0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C015g07719 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C015g07719</name>
        <name evidence="2" type="ORF">BQ5605_C015G07719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LWW0"/>
    <dbReference type="STRING" id="796604.A0A2X0LWW0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000003">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="219"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY17241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="362" mass="41335" checksum="AB7D6FEC751D28ED" modified="2018-09-12" version="1">MEDVLPKLWHRRYNHPTLEIQHAIHTREPWRRVEIALDLLAKGIRVIALHKAAPQLCVDVHLRNRLYGIRLPLRERVPAHRVCHGVFASRNRFVVRKDMEVDTHQVDTPLTQGVYDRQKLLFMGRVVDLRTDVLTRPICHRVCLAPILPLKQHGAYPNVTCVRHNPEGISGICVVDRLETWQRGDDGLYGVEVSLLLGTPHESDIGVLRFRGPSPDEILAVAARARFWSKINMTNSFFQTKMAEEDIPKTAVATPWGLFEWVIMPMGLSNAPATHQRRVNEALSSLIGKSCFAYLDDITIFSDTMEDHQTHVKEVLEALRWADLYCSPKKTELFRTSCDFLGHVISRNGIAADQSKVERIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LX17</accession>
    <name>A0A2X0LX17_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C015g07789 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C015g07789</name>
        <name evidence="2" type="ORF">BQ5605_C015G07789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LX17"/>
    <dbReference type="STRING" id="796604.A0A2X0LX17"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY17476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="360" mass="40088" checksum="175A6F1A0CAA0085" modified="2018-09-12" version="1">MKGSIIDPHTYLHGHITEPLWIKLPDGSTHRLRKSLYGLKQSGREWNKVLHAALVDRGFKRMEEDFGVYRRVRNIGGVDRTTLLAIYVDDGLLAGDDDLEGFLSEFDQQFKLKRGEVELFLGMKIATDDASGIMTIDKCHQIETILNNHGFANTSAVATPTSDSDQHSDGGTAHLMLNYRQVVGELLWVSGCTSPDISYAVTQLSRHCADPKPEPFRQMRRVLRYLRGTINRRLEYNRHLAIDVTLYCDSDHAGEKSGRRSISGHTVIMAGSAITWASKRQVSVATSSVQAEYQALSAAAGETLTVSNGIIELRWIGTKEMVADGFTKGLSRVPHESFVRMLGMVDAPRQGACWKGLREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LX31</accession>
    <name>A0A2X0LX31_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C015g07809 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C015g07809</name>
        <name evidence="4" type="ORF">BQ5605_C015G07809</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LX31"/>
    <dbReference type="STRING" id="796604.A0A2X0LX31"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043424">
        <property type="term" value="F:protein histidine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="entry name" value="HPT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045871">
        <property type="entry name" value="AHP1-5/YPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28242">
        <property type="entry name" value="PHOSPHORELAY INTERMEDIATE PROTEIN YPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28242:SF52">
        <property type="entry name" value="PHOSPHORELAY INTERMEDIATE PROTEIN YPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="Histidine-containing phosphotransfer domain, HPT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPt" evidence="3">
        <location>
            <begin position="82"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="1">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY17528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="191" mass="20529" checksum="4439581BD7CF53F3" modified="2018-09-12" version="1">MSHSTTPPTSLATAATTESSSHTSPTSPSTSTATLSASTTTTTAAAQQDDDDAAVGIAPATTGPVVDMEVFRQLLEIDDDEEHDFSKTLAIDYIGQAETTFTEIEEALDAKDLDALSRKGHFLKGSSAALGLHHVQHSCELMQHYGKCKDGSGEGADLTEEVALRKCRALLKRLRIEQDEAKAWLENFYKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LXK0</accession>
    <name>A0A2X0LXK0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">proteasome endopeptidase complex</fullName>
            <ecNumber evidence="3">3.4.25.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C002g01046</name>
        <name evidence="12" type="ORF">BQ5605_C002G01046</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="3"/>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY29366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LXK0"/>
    <dbReference type="STRING" id="796604.A0A2X0LXK0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03763">
        <property type="entry name" value="proteasome_beta_type_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000005">
        <property type="entry name" value="Proteasome subunit beta type-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024689">
        <property type="entry name" value="Proteasome_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF4">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12465">
        <property type="entry name" value="Pr_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0888">Threonine protease</keyword>
    <feature type="domain" description="Proteasome beta subunit C-terminal" evidence="11">
        <location>
            <begin position="221"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY29366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="278" mass="29486" checksum="8EF60D7CF5007C92" modified="2018-09-12" version="1">MAGFDFGNHLRNSYLGQRNVHLPKATSTGTTIVGCLFDGGVVIGADTRATEGSIVADKNCEKIHFISDNIRCAGAGTAADTEFTTALISSNIALHALSTGRKPLVVTAMTMLKQMLFRYQGQVGAALVLGGVDATGSHLYTVAPHGSTDKLPYVTMGSGSLAAMAVFESAWKPNMTRQDALELVCEAIEAGIFNDLGSGSNVDACIIEAKGTEMLRNYRMPNQKVDKERSYKWRRGTTAYTKEEVKYHLVKEEVTIVAGGKVAGPEGTGAAAGMEVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LXW9</accession>
    <name>A0A2X0LXW9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C015g07947 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C015g07947</name>
        <name evidence="3" type="ORF">BQ5605_C015G07947</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LXW9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY17994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="270" mass="31018" checksum="58E679BF5486A6E9" modified="2018-09-12" version="1">MSALHRRNVSSTRPSRSKDNSPSINVNTFPFSSIPTKRFNPRHLMPSCFISLLRRYIPILRGYMHRTKLTLPRVLCLCVILLYLVLYLISQLITYGRSHHYLPLVCPPTTASKPLWERQQSHRRVIPIYETLDQSHRKKLEVRSMSRLRKLKERLSPLVAKKAPLDDGMEVEEVKQPARPVKEPKEKTREEKAAHEHGLINVQGVQLPKKVASQVNYMDDVRLKAKPKSKRKGKAKPKPKGGKSKHWKHKASSGGKKGEGKKKANKKPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LY59</accession>
    <name>A0A2X0LY59_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C014g07654 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C014g07654</name>
        <name evidence="3" type="ORF">BQ5605_C014G07654</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY19462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LY59"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY19462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="305" mass="33746" checksum="C06CDCDA900207C6" modified="2018-09-12" version="1">MDSSQAPTQFRPSDHNTQRTPFADPDNDYTSNSASSDSTVTQLHASNLAPRSTTSHRIPLILAISGVLVVLFLVGLCVLAQVLGWRRRHSRVVKDGDSITKRSENSASEAGTVDRSKVAMKQAKHKWRSVWSTLCESGGYKFPIASFSSHTPKPTAPSLPTGSNPLGSPLSNYCPSFRSYTASPSYELATFPHMSPYPQVYYNHRLFDPNQGPPQVPLQLFDDAPLDPPHFYHDGTPELHPPVYQPNHQHFPPVHARLAQAQQQELWTWSAVNGFQPFLGGGDHLHSNVMLNSNGAQQQNYLQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LYY8</accession>
    <name>A0A2X0LYY8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C017g08535 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C017g08535</name>
        <name evidence="3" type="ORF">BQ5605_C017G08535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY20220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LYY8"/>
    <dbReference type="STRING" id="796604.A0A2X0LYY8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706:SF2">
        <property type="entry name" value="RFEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706">
        <property type="entry name" value="SLR1338 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="266"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY20220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="484" mass="51049" checksum="2C0F945F48551814" modified="2018-09-12" version="1">MGLAAKMAAAQAAGSAATPGYGTAGGAAAAPAYGAPPPQQQQQQGAYGQPSQQAQAQSGQPQYGAPPGQTPQYGAPAGQPPSVPGGRPAQPGQQQGQYGQQPPYGQPQQQQGHKALTVSKVNMANHKGNTAHRRVSASQQGQYGQTPQGQQQYGAPPQGQYGAPQQGQYGAPQQGQYGAPAQGQQQYGAPQQGGAAGVPEGPPVQAILDTLRAGVQDQNISAFYPPGSLERLAENVHRSRALPRIAALFQIPMEVAMDLVRLALFDVILYTDDSGSMSFEENGSRIEDLKMIVSKVASAASLFDQDGIQVRFMNSPVEGNNINSEAAASALVTQVKFSGLTPLGTAMHCKILEPLVLQPARQGRLQKPVLIITITDGQPGGEARDTIVRVIKAASQELRSTRYGSDAISFQFAQVGEDQAARQFLEELDVNPDIGGLIDTTSNYENEADNMMKANPPLELTPQLWIVKMLLGGIDSSYDTKDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZK2</accession>
    <name>A0A2X0LZK2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C016g08223 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C016g08223</name>
        <name evidence="7" type="ORF">BQ5605_C016G08223</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY21330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LZK2"/>
    <dbReference type="STRING" id="796604.A0A2X0LZK2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037850">
        <property type="entry name" value="RBBP5/Swd1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44040">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44040:SF1">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="64"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY21330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="556" mass="61951" checksum="95FFFC7DA74533D9" modified="2018-09-12" version="1">MNLELLNPFSQAFPENHDSALEAIALCARFNPHGVFAGHYLAVGRLDGVVSVLDFETKGVVRWLEGHIKAVTVVCWSRNSRYLLTASRDWNVILWDLAASSAEQIQGARKYTIRFDAPVTSADLHPRNRSVTSTAKPSGRCGRGVNFAEAETFDSNIVVVTLHSQVEPVFVDSRKSCGGRWHLETLQDQDKANEEDPEQDEENDAKKQDVATVARFNPKGDLIYVGTSLGNIHVWDVQTKQHLWTEYTDVPSSIKHMVFNKEGDAIVLNSNDRCIRVFRLLDEPWDSSMKQDAGDGASPMDTSGTNGAASLPRPPRIPYFHLQHAFQDLVERTPWNGCRFSQSGDYIFGGAGHKGAHNIYIWDSDSGGLLKILEGPKDPLEDVDWHPFRPLIASVSTLGLIHLWTTGIVENWSAYAPGFEELDENREYEEKEDEFDIANETVVKRRKADQQDRPVDIFTSHRDQLSSAPVNLDDEYEAYVSIEPDGDADEGFYPPLQLLDEYQGEPPVESPSDTTALGMVAEVEETGTISEELGIVEPEPAAVVAVTTGKKRSKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZW6</accession>
    <name>A0A2X0LZW6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g01838 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C003g01838</name>
        <name evidence="1" type="ORF">BQ5605_C003G01838</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY37580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LZW6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY37580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="133" mass="15074" checksum="8B2CCE2EE082D0E7" modified="2018-09-12" version="1">MKSSPVVSMVATAEEREQQLFAHMGKPRLSKAMDKYFLATPSKYEAKISKPTRKLGTEAAMREIAHAIKDVAQRWTNIKQLVDILRHHFGLHNQFNDFEVAAEEAKLGELWGPSGTMSHEAIISEIERLFPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M0K6</accession>
    <name>A0A2X0M0K6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C019g08854 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C019g08854</name>
        <name evidence="4" type="ORF">BQ5605_C019G08854</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY22767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M0K6"/>
    <dbReference type="STRING" id="796604.A0A2X0M0K6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008277">
        <property type="term" value="P:regulation of G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02987">
        <property type="entry name" value="Phd_like_Phd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001200">
        <property type="entry name" value="Phosducin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051499">
        <property type="entry name" value="Phosducin-like_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024253">
        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052:SF1">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02114">
        <property type="entry name" value="Phosducin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00677">
        <property type="entry name" value="PHOSDUCIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosducin" evidence="3">
        <location>
            <begin position="182"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="113"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY22767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="347" mass="37502" checksum="D25F3C315E2B4129" modified="2018-09-12" version="1">MDINDQFGGDAVAAEAAFVDGTHPALAGNGASAGATSARQQHRRHDSGSSAASSSSTTPRRALPRSPTSPSTAQDSNNAVHAPRRSNAANGAASQTGPKGVLADWHALNEAGVSATSNTGPKGVLKDHKSSQQQQQHPHQQIGLHNRPPSPTARMMAAAYSLDLDGHDSAGGEHDVRLLVGDEAARELYRRQRITELMGSGERKETKQKRKFGHLREIGFEQFVAAVEDEADDVAVVVHLYEPPPQDIEACTQLNTHLSSIARSYPRTKFLRALATDLDFAANAEEHALPTVLVYRGGELETSLIRFDQEWDQGTRSDVIQLLTNCDAISGSPIMRSRFDRFTDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M1C5</accession>
    <name>A0A2X0M1C5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C003g02358 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C003g02358</name>
        <name evidence="7" type="ORF">BQ5605_C003G02358</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY40354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M1C5"/>
    <dbReference type="STRING" id="796604.A0A2X0M1C5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052405">
        <property type="entry name" value="Mito_Transl_Release_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203:SF1">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION RELEASE FACTOR IN RESCUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203">
        <property type="entry name" value="PROBABLE PEPTIDE CHAIN RELEASE FACTOR C12ORF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="6">
        <location>
            <begin position="67"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="23"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="137"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY40354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="192" mass="21621" checksum="5FAFF880C25A5FA5" modified="2018-09-12" version="1">MLRRWLVAPLKPAFLHPSLQSYRHSSNEASSPSLPSTASTITPDRPKGKSRTPPKNLQLPPFPPLVEGDLEEEFLRGRGPGGQVINKSSILVSLLHVPSGTRVKCQETRSRESNRLIARKRMQEKLDVLWNGASSRQELKRERERSKKAAKKRKGIRKRREGEDSLVEDVEAQEEGGEEDLLTNAQDARGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M3S4</accession>
    <name>A0A2X0M3S4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">BQ5605_C001g00580 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">BQ5605_C001g00580</name>
        <name evidence="17" type="ORF">BQ5605_C001G00580</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY47835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M3S4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="16">
        <location>
            <begin position="740"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="303"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="SGY47835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1007" mass="111590" checksum="3089703C119F77E7" modified="2018-09-12" version="1">MKCPFLFYSSRFSDLILSLVHYHLAGSIACHPLVTVSAALIPAPHSPQCSPSQYYNKASKSCVECSTKFTNATSCKRNRPTACSYGRVSNGQCRARIGYSGSRYVTANGNSMPTRVPNHSFTSGVCTAVSCTGNLYRAPSGRQCRRCRSFDRHAASCDSDGTLRGCESGYSLKSNKCQADPTTTQSAEAFPRLQPRALLAFPPLSQACLSLQLPLLWTPDCDYYPFAGSTNRNHHTRVGYHDDPSDYHCQKAADVNTMAGPDDRASTPPPSSTSTQSQNIDVSAIGSITLTREQYEELVRYQRTRDEEAPTPRQLLPPEAPAAFPEDSKLKGDNYVDWDITMSLTVDREVCAYLRRGTIDPTWTPTVRSRWQDYALHVLARSLTPATKATIGPVVQRGGSAHDCWLALTARYAPSDAQGHSSLIMNYFGMPQCPSTWKGFIDWSNRALVLINRLRMAQLDMEQAMAARAMNNLPPLFDSWRTTFYALQADKNKLPRAEDIFASMEAVARISRNESTPALVAKADVQTQSAAPGRKGKWDRSGLAPSNCPACGQGKHWADKCPDSVKCTKYFELKNAMKELKGALLAPAPALAATKSSWLPLLTLHRRYGHASVQTLCHESAVRGASSYLYDLAPRSLPLASTCFHEFLSLSLGFPATINRASYSYKNNYINPASRPVILAIACCLRLSNLNPDTLKKLAASGQVKGLDWTYSDSECAEFTCNACLASKAHRSPFPSSLSHAAEPLALVHSDVLSFPEESINHFRYLVTFVDDYSRKTWVYPISHKSDVLPTFKDWLLEIENATGCRLKTLRSDNGGEYISSTFNGYCAARGIRCELTIPYTPEQNGRAERLNRSIVEGTLALLSHSGLPRLCWDEAAVCFSHTKNLSSHAALKGGVPNHRWSGTAPLVTALRAFGCRTWATVPGHRRDKLDPKGIPLVFVGYDRHAKAYRLLDPTSMRVSLSRDIKFVETEFPFLSIERHEIALEPHWFRVQTERIKRCNSQAKKDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M4R7</accession>
    <name>A0A2X0M4R7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C003g02113 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C003g02113</name>
        <name evidence="6" type="ORF">BQ5605_C003G02113</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY38969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0M4R7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019783">
        <property type="term" value="F:ubiquitin-like protein peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="5">
        <location>
            <begin position="226"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="356"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1577"/>
            <end position="1650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="388"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="418"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1591"/>
            <end position="1610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY38969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1650" mass="182001" checksum="B9D1A8BFA9138083" modified="2018-09-12" version="1">MIPCLFLDEDQDYYLHDDDFDRLSALTNLTVAELLAFDVAPADASLHIELSKDEPTQYSTLPYPTLQTRDAFLATDALINAHKKGYRSLAVGSTCLPLGADRLWSEYDRAKDVQSWALRAQRWMDKIFQDGLLPLPLLASGTSLVYLLRFLTVVNLSIESVLRAGRVQNPDFETSYGLIPSTVISLVMARPPDSDPHSVFKACFFGPPNQYRNLIELGDCMRNTPTSKSTWFLPLCSDSHWVLARINMHKRTWSVINSLSATPITAATRTAVLTLFKFLKLDIKNEFPHTPKAEQQEDSYSCGPATINAVETEVLGIGSFNAARAHMSRLRQFCRLSSLLGAVEDPKEIESIVATGAKSKAKSGRGSAAGTLSSKSTSAESGKAATIKPTNQRVASSSKNPPTSRLQTTFTKASKPTKARELTPEEHTTWARDHPPVFRRLAEKVEDLCPGSNVDVNNPKYVRCGRCYVLVPLAALLCKARFELHLGNKKCVNLQPISNFFRPIASGSTATSPSLGPCPGLTSETAMHYLSPTAAQGGGAPPRRTLCLRLYPKIGKRPMTELERKEVDKLEANEWKWRNDHRAPRIISVNCRKYSARDSINKDGPSLPCEECAKLPKNSSCRAALRRQYAAGATRKYTNKKYVAGDTLLSAIYRRHHGLEEILDDNSQGTVYLRFAQGVASGEFDGANILEGLVKAATVKHDRMVKGKSMRGFVRSEALRDIEQAMALASPMALRVLQATIGASTSRKLQMRLGLDKSNMDRVCAKLEADGLTFNLHVDDTKCRSRMRTTPYYSEDLSLERDLRTKGIFRHELIGSIGPPRIYETPGELPDMFSGPDPPVAGTKIRAYMIAPNDVGSPAQVFAAFVIGETTNAEDATEQLHSVIQELINRCVAHLLVSISADGAASEGVLQRNVAVLLRDQGGAVAQTGSRNASSYTLPSPDPDGVFPEITISTVNVAGTPIVFCRDEKHLAKCLRNAIDSGARLLFGGLGCIAYQDMLTILGGMESRRTLSRRDVVGRDRQDDNATHRAFSKATLELVTELAEDKKTTPMRSHISSYVASYTIPSRTGRFSPLNVSGCCSLSGIRSRRGMTLSEVAPDLALTRSSPKKRLMGSGRWLTQRLLSSATTEIFGQRNRSFPGGMAQKWWSTSSGVYARLIRQATGKVTALLELMRKFKTEAAGSRQGYHHTYNDLNDLDLVAMRTYPSDGDISLTSFAAANTARELLSGLRMWEPVQRIASNTRNQGPQPDILVEDVLARGTTVQDLEDHHPTKEDQGLLRTELLDSALDGMRRSTCQGVVKLDPNEREAVDRAIRSLAALDFDVEAALFDVQIAYDEADRQAEERYVLETIEKANSSLRPIPTHLKLPPLVDARDTSFSLNWASLIAHRAAHERSHLRAVLLKGRPINTEQGRSAVHSRVLKGLVQSMGPSRFEDIAGTARGFRWTGGGQDGRIQEKLPERDKQYGALAQRYPHFGSLDGAVTAATPLEIRSLICFGLKCGMHSLSGDQTVYGEEALSIGIVRNIYSKELRLIKKTCYSTHLIDGTMPFRMIDARAHMPSKGLPPFGACPACEMPPAEPLQAAQMPPRKQGAQLQQKGSLTTKQRASQQSKEGLFEAWSHAQHQPKRRAPQATFDRPRRARKRSERVFEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M561</accession>
    <name>A0A2X0M561_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g02253 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C003g02253</name>
        <name evidence="1" type="ORF">BQ5605_C003G02253</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M561"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY39641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="65" mass="7274" checksum="9E7554EDF59C0A8B" modified="2018-09-12" version="1">MLSFVLLQLEPLFRYDSREWSGESKSRSNHWAYGHVTSSPGPLQAQVDRSLLPDSLDAQTQLGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M5N7</accession>
    <name>A0A2X0M5N7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g04009 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g04009</name>
        <name evidence="1" type="ORF">BQ5605_C006G04009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY55358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M5N7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY55358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="299" mass="34152" checksum="7D0EA411C411F6D2" modified="2018-09-12" version="1">MNNRKNTIVVTNHSRNRLWSRELRLTSPWQILNGSVRWSDRRDPEQCLPVIPKSSPAQIVDACIMNADFCGDLSELETARRTKQKTLSRSHVTFSCRRPRGTSGLIRHVYPVPALELDNMSKGKKVEYFRERANLAPKDSQVDHINDMGLDLLPGDAQTFYSADSDAFVAVDAGQQHTDSRITQENRLRLRELQLTIPWQSCWQGIRSNAFPLFFKSSPTQIVDTCIMNADFWVEVGVLLDFVRLRIRVHGTLNVGRTATTSSTGKARARAFRSGPTQFFAEPCLYRINIDKSFYFQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-03-27" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M6N2</accession>
    <name>A0A2X0M6N2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g04329 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g04329</name>
        <name evidence="1" type="ORF">BQ5605_C006G04329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY58005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M6N2"/>
    <dbReference type="STRING" id="796604.A0A2X0M6N2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY58005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="183" mass="20621" checksum="738CB40840105C86" modified="2018-09-12" version="1">MAGATVGPGCGVLSYIRVVGFKKKSERHEIALEPHWFRVQTERIKRSERRLTPGSTLLWEDNQAVIAIAQNPTHHGRTKHYSVQHFYICERITTGDIQIKYCKTGAMTADLLTKPLARNLFELHRDGLGMGQRSRGTCGIGKLARAWRGAGWRQMAALVSFTLSFFFNTHSISISPIRLLQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M770</accession>
    <name>A0A2X0M770_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C007g04460 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C007g04460</name>
        <name evidence="7" type="ORF">BQ5605_C007G04460</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY60636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M770"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23513">
        <property type="entry name" value="INTEGRAL MEMBRANE EFFLUX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23513:SF6">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="455"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY60636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="531" mass="57417" checksum="F1C524FE0AD7E0A7" modified="2018-09-12" version="1">MTNFAEVWRSFTHEEKRNIAWYILGIMMYKLGLEFFNGSITTLATDRFRAANTFTKLGAAQGVNQAMQCVGAILIAPLVKALPTRTVLAGAVTFFALMTTLLLIIDAATGGSIKRAGATKPDYGSWNPNLIFVIWSLSGIAYGMVELIRRVIPADVVGGNVSKLRRMDATVHVLYEVAGTSGAFASSAAITRLGNNYSFLVSPIFFVLAAVAWSFVGALRTNHNEANGDEPALAAVDKDGKRKNYFAAVGNGAYLFCKSVGLGAWIVMSHRRFIWLFPGYALALYLHRFLESSLAPAFARRVLNVSAYSQIIVGGSNFGELLGAATVFLLSDYVPTPLPWLRLDALALNIVWILPRFSQIAKPRQVRWAWYIAACFIPISFGWAAGDVSLAAYIQSSLTTMDFAAAKDVSALGAVMAFLYSTYIVFNAVLSSVLGRVIDQDFTRTGTIYKALQQVGGIQFSVASALILLATLIPMGAFAFNPKMLNSMPLEGDVAHEEALDAEYVAKGADGTYGSDSDSVEREKKLAAISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M9S9</accession>
    <name>A0A2X0M9S9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C006g03983 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C006g03983</name>
        <name evidence="3" type="ORF">BQ5605_C006G03983</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY55182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M9S9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="147"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY55182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="597" mass="66569" checksum="8FA31B467655FC60" modified="2018-09-12" version="1">MRPARSARLSPDLSREWIPHIDLIGSQPQVRFDPPAVHHPDFSTYREPASAEESPDELDLIGRPSHDKSPDELAFLIRHHRAFIATDDDVSDAEAIQPVKSITSDPQTWREAMSSDKREVWAKAATDEFNSMRDDFKVFTINDRSTVPAGATIVTSKFVWKTKRNALGDVTGHKARLVAQGNRQRDGIDFNETFAPVARFSSIRSLLALAAANGLHVHQADINKAYLHGDLDHDIWMTAPRGFDLPSDKVLRLRRSIYGLKQAGRIWNRHIDASLRALGYTATGTDHCIYSRLDDLQRPHYIALYVDDLLMISPDLAEIEQYILGIQIRRLDDGSIALSQERYIMDVLARFHFDTTTRGTTVPMTPGLSLTAIPGQGTEQIRSWYLQAIGSLLYISLGTRPDIAFAVSYLARFANNPGQRHWIAVKHVLRYLRATYRDELLYTRGKTGITGVVGYSDANWGACRQSRVADSTTDAEYLALSHAGKEGIYLSQLLEELHVQSGIPAHICTDNEAAAAVARDPVRASGTQHIRLREHFVRDMVNRGEISLSHVGTSNMVADIFTKAIGPKIFSMHCYALGLRTRHPRLGSASHSRGGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MA97</accession>
    <name>A0A2X0MA97_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Histone acetyltransferase type B catalytic subunit</fullName>
            <ecNumber evidence="3 11">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">BQ5605_C005g03252</name>
        <name evidence="18" type="ORF">BQ5605_C005G03252</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic component of the histone acetylase B (HAT-B) complex. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the HAT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 11"/>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY73036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MA97"/>
    <dbReference type="STRING" id="796604.A0A2X0MA97"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.360.10">
        <property type="entry name" value="Histone acetyl transferase 1 (HAT1), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019467">
        <property type="entry name" value="Hat1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037113">
        <property type="entry name" value="Hat1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017380">
        <property type="entry name" value="Hist_AcTrfase_B-typ_cat-su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013523">
        <property type="entry name" value="Hist_AcTrfase_HAT1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12046">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE TYPE B CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21184">
        <property type="entry name" value="HAT1_C_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10394">
        <property type="entry name" value="Hat1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038084">
        <property type="entry name" value="HAT-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histone acetyl transferase HAT1 N-terminal" evidence="17">
        <location>
            <begin position="5"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="16">
        <location>
            <begin position="240"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with histone H4 N-terminus" evidence="13">
        <location>
            <begin position="249"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="12">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="272"/>
            <end position="278"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with histone H4 N-terminus" evidence="14">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR038084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF10394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="SGY73036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="419" mass="48794" checksum="289719DF8D1944DF" modified="2018-09-12" version="1">MDEEWSSDALEALQLRLVRAKADVAVLEQGETDLVDDFHPTFVYPIFGQEETIFGYRNLEIQLHFSSGALKQYLHVDYSSKFPSTTTVSADDPEKTLYEFIPPTYSKDEATFHSIVEADSTEFKPLGNKIGAFRERSEEEMEEATGSGKGKGKAKRSGIEVPPRPWKLVEQGDEEEDEEVLYEAYQTTWDTPGFKEYHRRMQIFVLLYIEGAQYIDEEDPRWEFVTLFERRKRQDGSFGYHFVGFVSFYSFFCWPDTKRLRLAQFVMLPPYQGQGHGSALYTLCYNHVLSRPEIIEDPSEIFEDMRDKCDLHTLITSHELDDLSAPLNKPALEVIRKKYKIADRQFYRLIEMLLLLNLDESNVAQVKAFRLTVKRRLFTFNREMLTQLEEQGKKDKLHETYTGVKADYRRITAKFTSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MAY9</accession>
    <name>A0A2X0MAY9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C005g03472 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C005g03472</name>
        <name evidence="2" type="ORF">BQ5605_C005G03472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY76184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MAY9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY76184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="84" mass="9135" checksum="671F859E18F25D5A" modified="2018-09-12" version="1">MSNQEQEFKIQPHPTKDNIARSFPGSDAEGTAGLGGAPNLAHLHKAQDPTQARGPHVPKDEIAMKLEQPKSREELQALAKSLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MCA6</accession>
    <name>A0A2X0MCA6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C007g04864 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C007g04864</name>
        <name evidence="25" type="ORF">BQ5605_C007G04864</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY64047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="505"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="741"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="747"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="23">
        <location>
            <begin position="760"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="771"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="23">
        <location>
            <begin position="784"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGY64047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1422" mass="158003" checksum="B16F6C68E4F2E2CD" modified="2018-09-12" version="1">MSSTGESDFPNGSGNRLYLKDTQGYKSWSQRAFINLRADKVWDVVNQSIDSLVADYRSTLVIAHATALTSVQVADKVAEYRERAIRRNDLACKYIANSISEEQMSYLIHLTSAYEMWDTLRGLHSHGRPSRTMDLLNTLAQPYSGDIPFKEFVNKVKIAMTDFQNLGAPLPHWLFAGMLVRSLPAQYDSIVGNLASDIDIHMDWNTFYPKLLMNVEMADSRNKQKESLSARIVDDTSLVARISTTAQKDYSKSYCSRCKALGHERGWRLCPSRNKDASAPASSDSNSNVAAIGVDESALMTYTFPYSRTMPRFPWIIDSGAKVHCVGDKSVLLDVVSEPLKISVADQSQIESPGHGSVTFLTSYGARITIKRVYYMPGAQCGFVSIDRLLESMTYAVGPQSNLIFSIRGKSILRSLPGRGFVMDAAPVQPIMSSSPPSMVGANRLTGTCTLMEAHRKLGHQSPAAIVLAVKSGAITGITLKDEKVTPCFSCIQAKSKRSPFSNKSTEAPHALYRVFIDLGFVEHPNHHGDTIYLAIVDQYSTAKWTIVLKDKRAETIIEAWSKFQAESERQTGQKIKRVRSDNGREFDNSLFRALLEKQGIIVEFTAPYTPEQNGQVERLNGSLMGLVRSMLLDSGLPMRFWSDALAVATFVLNCRPHPRIQGKTAIEVLLGKKPSLAHLQPFGSTAFVHVPKERRSKLAPRSIQGVFIGYSGEYNYRVWVQSSKQVYVSRHVTFLETPSVVTSSQDRADASDPVHHSQPPHPPHPPPDVLPSTPTSPVVDPTLPDPQPPPVFPIGVGQQGGYLAVVPQEPLDSEAEVALAPCEGYAIVRTGPNPGQFENVDPSNILPAGSRRRPQPPENILPIISAIMVDVLDTPPMFHDKLFYDAYCAAVFAEEDIEIPKTFEEAMKSPYRNHWSVAMVSELLQFDHHGVFQEVKWHEGIRVLGTIWVYSIKRDANGKIIRFKARLVAQGFAQRPGIDYHDTYAPVARSSTILFLIALAAAQGLYLEQFDFDCAFLNGKMTEDVYVRYPKGWNHPQSPGKCLKLVGSMYGTKQAPREWYRAVNDLMVSRGYMRATADACLYIKHSGTSFSIITLYVDDGLIASNNQSFLDSELGSLHKAFQLKRLGPVSYFLGFEIHRTKDYILVHQSKYVRTMLEKFDFASPSKRRAITPMDDCPSLRIDATPFADVSLYQSAVGSLQYTSTRCRPDIAIAVRAVAQKNSCPTVDDWAAVKRIFRYLNSTINLGILYRNSSTTRLMVYSDASFADDPESRRSVGAYASMLARGVISWQSKQQSMIATSTTEAEILSASSATREAIWLRRLAGDVGIPQAQPTIIQEDNAACIQIAKDPVNHMRTKHFDIAHLFVRERVASGEVELEYCPTHVNAADIMTKPLGFQRFDQLRALLGMVSLVSLTGGSVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MCB1</accession>
    <name>A0A2X0MCB1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C004g02859 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C004g02859</name>
        <name evidence="7" type="ORF">BQ5605_C004G02859</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY68165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MCB1"/>
    <dbReference type="STRING" id="796604.A0A2X0MCB1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015086">
        <property type="term" value="F:cadmium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034755">
        <property type="term" value="P:iron ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037982">
        <property type="entry name" value="Nramp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706:SF101">
        <property type="entry name" value="MANGANESE TRANSPORTER SMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="SOLUTE CARRIER PROTEIN FAMILY 11 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00447">
        <property type="entry name" value="NATRESASSCMP"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="465"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="508"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="532"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="623"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="364"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY68165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="656" mass="70881" checksum="F66EFB1C239C3488" modified="2018-09-12" version="1">MPAATRNALQRVVDGMNPDTENENDIGMIKGHTPLRSPRKRTTIDRLKRKLIAHAKFVGPGVIASVAYIDPGNWATDLQAGSQFGYSHLFIILLSGLIALLFQVLATRLGCVSDLDLSQNCRRALYDRPKHKMVYRWGVLYPLYALSEIGIIFTDLAELLGSAIAINLIIPAIPLWGAVLITSLDVFLILLLFDQYPTRMITRSMRMFELLIGLLVMTVLGSFVALLVKVSPVWKDVFHGYVPGPGIIRGGGLYVAVGIVGATVMPHAFFIGSKMATMRRLAPDQYAYDDDDEDLMDEKNTAAVRMRDVSTMPNPARRPSHGGGPHLHLPQPVALGNFNIHSNRNRAITSTSASTAADMIVETGSTSPAENSGDAASKKTDDGKNPAPLSDHPKPTLACVRAHLGHAVADVAGSLLGFAILINSSILILAAAVFYYGKGRSSVGNEGVSDLFDAFDLVKQYLGQVFAYLFAIGLFMAGQSASLTVTLSGQIISEGFIEWHTTPWKRRLVTRLIGIVPSLAVAVAIGREGISVLLVGSQVALSIVLTFVLVPLIIFTSQSHIMSIPITSPGESSAPISTPDSFPQASATPLLVESPIFIRRSLKEIFRILNPVRKRAAPEGHVSFVNSALIVYLCWALWLLITIANVLALYDIGAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MCR5</accession>
    <name>A0A2X0MCR5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C004g02608 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C004g02608</name>
        <name evidence="8" type="ORF">BQ5605_C004G02608</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY65947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MCR5"/>
    <dbReference type="STRING" id="796604.A0A2X0MCR5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF6">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="68"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY65947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="509" mass="55831" checksum="FE28660893EE9700" modified="2018-09-12" version="1">MPALLSATSSNTVEGLEFSKQVKSHDSEKLESVSVGAENVEHDGVAGEAGGFDRTRLEKRLVRKLDARFAILIIIYILNYIDRNNISAARTKGLEVDLKLTGSQYPTLLSILYVGYILMQVPSNMIVKKMGRPSIYLPLCMAIWGLISALTGITTTFIGALLTRFFLGFVEASFFPGSVFLLSSWYKKDEMGLRTAILFCGSLISNAFGPLMAAGILANMEGSFGGREAWRNLFFIEAIITVAVALLAVPILPDFPHNSRGFSQAERNIAMQRMSEDVGVEDEIEVGAFRSLLDTLLDPKAWAMALTLTALVVGLSFNQFFPTLTKTLGYSNTVSLLLCAPPFFFATLCAFFVGRHSDKTQERAMHIIVPVLIGILGCIIAMSTEAVAARYVSLFLLAQTYAGFVVFYAWISNTFPRPAMKRGIAIAFINAFSQLGNISGAYTYPKNWGPSYVKSFGIVIAMFSTCIAGVLFHRFTLGRLNRKLVEAEARGESCELSGVKLPKGFRYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MD62</accession>
    <name>A0A2X0MD62_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C004g03139 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C004g03139</name>
        <name evidence="2" type="ORF">BQ5605_C004G03139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY70325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MD62"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="334"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY70325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="360" mass="39123" checksum="D7ED8AC9AFFF408E" modified="2018-09-12" version="1">MAQAPSSGFLTISGLEQCYGVKRLGPAEYILGIQIRRLNDGSIALCQERYIMDVLARFHFDTTTRGATVPMTPGLSLTAIPGQGTEQIRSWYLQAIGSLLYISLGTRPNIAFAVSYLARFANNPGQRHWIAVKHVLRYLRATYRDELLYTRGKTGITGVVGYSDANWGACVNTSVSTMGFVFYIAGSAVSWSSKRQSWVTDSTTNAEYLALSHAGKEGIYLSQLLEELHVQSDIPAHIYTDNEAAAAVARDPVRASGTRHIRLCEHFVRDMVNRGEISLSHVGTSNMVADIFTKALGPKIFSMHCYALGLRTRHPRLGSASHLRGGGGGDESTLSSAESPRSLRAPASPPPCAGDLDARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MD87</accession>
    <name>A0A2X0MD87_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C005g03171 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C005g03171</name>
        <name evidence="1" type="ORF">BQ5605_C005G03171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY72440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MD87"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY72440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="98" mass="10495" checksum="DC3889F6B3F80ABD" modified="2018-09-12" version="1">MLCLHSRTDRSISQLAAWTFATGGGTTRVATLVKAHEDGTSIAATDCCPQEGGRRLTTFLGQPQISDRPAQRPSPELARTSFGGLFHPCIGARRNGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MEG3</accession>
    <name>A0A2X0MEG3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C015g07802 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C015g07802</name>
        <name evidence="1" type="ORF">BQ5605_C015G07802</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MEG3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY17514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="146" mass="16607" checksum="F9DF6D9C4337F1FA" modified="2018-09-12" version="1">MTLGPFAFTLRRASQCSRRLYRSLVIFYDDFDRLSPLTNMAIAELAFGTRDVFLATDALIRISTFGRRVDKQYGALAQRSRHFGSLDGVVTTATPLEIGSLICFDLELRFIKKACYFTHIDGTMPFRMIVPHDCSACLFRMIVPHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MET4</accession>
    <name>A0A2X0MET4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C005g03419 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C005g03419</name>
        <name evidence="4" type="ORF">BQ5605_C005G03419</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY75336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MET4"/>
    <dbReference type="STRING" id="796604.A0A2X0MET4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044695">
        <property type="term" value="C:Dsc E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045226">
        <property type="entry name" value="Dsc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025390">
        <property type="entry name" value="Dsc3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019413">
        <property type="entry name" value="Dsc3_ub-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28049:SF1">
        <property type="entry name" value="DSC E3 UBIQUITIN LIGASE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28049">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN YOR223W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13373">
        <property type="entry name" value="Dsc3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10302">
        <property type="entry name" value="Dsc3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSC E3 ubiquitin ligase complex subunit 3 ubiquitin-like" evidence="2">
        <location>
            <begin position="134"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="DSC E3 ubiquitin ligase complex subunit 3 C-terminal" evidence="3">
        <location>
            <begin position="308"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY75336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="427" mass="46114" checksum="E54C8EA060204DDC" modified="2018-09-12" version="1">MFDNDNDNDGFDLGSSRPNGTSSSSSPSPQPGEVLPFGHSSASTRRGSGSGSTSGSGLARFISTTNSADDGLPLPVAASNTILPRRTKRFVASAKGKAKAVNDDEAVGQALLSGHDFGEDGERSSSGPTGMAFSIRFTDGSEDLLDLCVGEKESVAEVKRRIRFLRPNLMHEDRPRRLRLIQLGRLLTDGTYLVPWTVQLLSRRAKLVRQQTQPNAEALLEGAIEGIEAAVGVTVPRASIDLKGGSKQDAAQQRRDSKGKGKEKDMTLAGTEAEDDKQVWLHCSVGEPMDDEEIDSERIQTTQITPLQGFDRLRDAGFSEEEIATMRAEFRRNNSAGGDDDEHARALEDQWMEGLAGQNEAAATESTTEGYWMKMLGGLCVVEISNFFAVPVPPNSHLNIISIDSTQMAIVLGVIINVGFGIMRLFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MGF2</accession>
    <name>A0A2X0MGF2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C008g04991 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C008g04991</name>
        <name evidence="1" type="ORF">BQ5605_C008G04991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY78925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MGF2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY78925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="54" mass="5678" checksum="844EF8D5CD95C496" modified="2018-09-12" version="1">MSLLSDLVHLRTIEHGSPVGAFSPGAPLGRILQEESACERAIPTSAPLVVRSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MH66</accession>
    <name>A0A2X0MH66_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C008g05231 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C008g05231</name>
        <name evidence="9" type="ORF">BQ5605_C008G05231</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MH66"/>
    <dbReference type="STRING" id="796604.A0A2X0MH66"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000012">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000107">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF5">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="64"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY79827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="379" mass="41902" checksum="08C8BAA8F99DCB74" modified="2018-09-12" version="1">MQTSTSASLFGGASSSAKGKAPATEPVAAYELPWVEKHRPKSLDDIVGNVETIDRLKVIARDGNCPHIIISGSPGIGKTTSILALARQLLGENYKEGVLELNASDERGIDVVRNRIKAFAQKKVTLPPGRHKLVILDEADSMTPGAQQALRRTMEIFSSTTRFAFACNQSNKIIEPIQSRCAILRYSRLTDAELLRRLLEICEIEKVEYNEAGLTALIFTSEGDMRQAVNNLQSTYSGFNFVGADEVFKVCDQPHPVKVQQLIKDCAKGDIDAAMTKLEELWLQGYAAVDIVATLFRVTKGMEDLLEYVKLDFIKEIGFAHMRILEGVSTVVQLGQSFRPVFPEKDWLADDFSCKSSLTGGLLARLCKLSMKPELFRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIF7</accession>
    <name>A0A2X0MIF7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C102g13150 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C102g13150</name>
        <name evidence="25" type="ORF">BQ5605_C102G13150</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000073">
        <property type="protein sequence ID" value="SGZ10684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="591"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="1753"/>
            <end position="1861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="920"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGZ10684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1861" mass="202969" checksum="D4616E6641352D80" modified="2018-09-12" version="1">MDTLSPLTAGAHPTIPARTACPHLPLPLLADDIRSYVLDGIVPADWTPWHRSARDVVARKLLANSINSANISAVLDQIPTADLTAPKIYSTLKLRYAPDDATRTLELFSQLWIGSWSSKAIAQEIIDTKTTINDVLATLLLAITHLSLESFKASFTDEQRVEPNVAAQPTRVIKSSCPVIRTLWYQGEQPLSSMSNPAISTRHATCATREAGRNGSTTSKPNARTDLEHANFQAIALLRRSVSLNIKKQIKDGFDHTPTDVLKMIKKAVAAGTVTDIFIKLQALLDAGPPPSGVDAFEKYQANTIELFNTLSGYNLTFDQVISIRLIHFGKDLYKEYYTQALRQDLDKLPDPIEALQTLQTQAESTPAHKPVAMVASLTATDRSSSTPSAPCQHCGGPHWNRKCPVKDKKSKASSAPSASLAAAPDISTLVDGPVRGYLTAAMSTLAKPSLILDSGATHHIVNDRACFTNFRKCKPAPLEGITSEAVNSIEGVGSAVVRSFDGSIGQLHHALFVPSAPVSLFSASRANAAGYDINLSRGKATVSVDGNRLISTEAVLGVNMEVALNADLKCDTCQAGKITHHPFPTVASNRSAQPLDRVHMDLLAFDGAVSLGGAKYTLVIVDDYTRYLWAIPMSHKSDTFAAFKSWLAKVERSSSRKLLAVRSDNGGEFLSNEFSSFLEEQGITRQLSIPDTPQQNGVAERANRSITEGVRSMLHQSGLSHALWAEALATYVYVKNRSPHSANSGVTPHTRWHGSKPSAGHLRVFGCRAWKAATTEARSKLDPRGIPLVFVGYDLESKGYRLFDPATRQVFKLRSVTFFEDEFPARREGITAAHAPVAGDDDDDDDDDDEVVVLPDQHANQAPPDQAELPAVLRFDTPGPPRYGALASLRSTPSAFAFSLGKEVTELVADLEAAGIDTSTANRPLSEPEDPFSLPSSDPTTWNEAMRHPHAAAWKAGAIEEFRSMKDDLKVFSVVGLSSVPKGATILPSRHVFRTKRDKAGKMVSLKNRIVAQGCAQGPNSFNNTFSPTAKYTSIRTLIAHSASKGHHIIQADVDKAYLHGVLEEEIYMRVPTGIEGYEGKCLRLHRSIYGLKQAGRVWNDTINATLASLGYRRLACDECIYRHEDAGGDHYIALYVDDLLFFGPDLGEIDRVLDQLDTLYGVKRLGPAEWVLGVQVVRHDDGGISLLQRQYLLDVLARFNMSDCNPCKSPMEANLQLSPEPDTDSADNAIYRSMIGSLMYAVVATRPDLAHSVGYLSRFVGKAGDTHLEAAKRVLRYIKGSLDLGIHYTRTSAPLLGYKGYSDSDWGSDMQTSRSTMGYLFKLAGGAISWSSRLQPRVACSSTEAEYLGLSHAAKEAVFLRSLLTELGLDTSSPLRLLGDNQGAIALTQNPVFHARTKHLRMLEHFVREHVRNGEISVTYIPTHDMVADIFTKPLPRVVFQRHCDAIGLRRISGQEQGGSARSNRVFPSSSPLDYELIGLPLPPTRSAHRCSISTQRTQRSRPAIDSLANRMRVQLWSTNVPSTTSALLASSSRPTRPKCLACRSPSHRGAECPVRAKHPPPGPCRSCKQNHWSFDCKKALENSNRPDTADSTADSQHHVGCLATGLLAHCCQLRANSFVIDSGATSHMVSDKGINAIGTGNIAFIAASGHPITLTGVLHTPGLPVNLLSVSRLCDTDNVRVAFTKYGIHIDKDGNNIAEGARLDEGLYLLDADHSKYGCHWFAGGSRAGYSDKEVEKFVCNACLSAKGHRLPFPDSDSHSSERLGLVHSDVLSLPERSLTGKQYLVTFLDDYSRKLCAYAIGHKSKVFGVFKTWLAEVKLETGATLKVLQTNNGGEYRSKAFTDFCKARGTHRQYSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJ02</accession>
    <name>A0A2X0MJ02_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C039g11766 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C039g11766</name>
        <name evidence="3" type="ORF">BQ5605_C039G11766</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000060">
        <property type="protein sequence ID" value="SGY89745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJ02"/>
    <dbReference type="STRING" id="796604.A0A2X0MJ02"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024624">
        <property type="entry name" value="Pyridox_Oxase_Alr4036_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28243">
        <property type="entry name" value="AGL049CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28243:SF1">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE ALR4036 FAMILY FMN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12766">
        <property type="entry name" value="Pyridox_oxase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding" evidence="2">
        <location>
            <begin position="118"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY89745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="321" mass="36076" checksum="E1577E305525D451" modified="2018-09-12" version="1">MSFADNVRSHESNITGSRPSSTPASPSAGPSSAKRAKVTVDQASETPKWIERIHQVLNHEKNKDFLDARAFRFLLKCRAAELLSRRSARERSSALPQSAAVSDRHLSETNRRIGLRTCAENIVVSTVKDGQPYARYHVFRGFVPSPGSKQDSELLLTTTDATMPKVDQIESSSNSTGGAPSEIIFWTSPTGDQIRLRGLIYLYLPPSTRNSSDSRQPIQDRFPDFDFEALRQEQWKSLSGHLRASFLRPKPGSEWPKDKKYEFQERLGLGEEGEDEAMKRFSLVVFEPAVVDHAKENSQPPVRYVWTKQADGSWEETQVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJ11</accession>
    <name>A0A2X0MJ11_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C029g10606 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C029g10606</name>
        <name evidence="2" type="ORF">BQ5605_C029G10606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ14620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJ11"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ14620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="232" mass="24859" checksum="0CBF2FF88D415932" modified="2018-09-12" version="1">MVEQGGNNPGGTGDAAGLPNTAPSARDRQKLRAAQVSQDEEGGRASGARDVSANVCAQLGTHPWPTKNVETKCQWYNIILKELFQSALRQRSVLDGETIQSPKFVYDVKALRDNARIIAQRGALLRKADFRSPSSKLKLLGRPGSDHLIAACRRAELQAGGRAMLTGGLGTRAPTSTASEVTMAELSAPAGLVDAHAVRRSWLLKGQNSLDNTGHHNRSFIVLLHMHPALGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJ98</accession>
    <name>A0A2X0MJ98_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">BQ5605_C038g11684</name>
        <name evidence="20" type="ORF">BQ5605_C038G11684</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="FQNC01000061">
        <property type="protein sequence ID" value="SGY91603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000003">
        <property type="entry name" value="Transposon Tf2-6 polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032549">
        <property type="entry name" value="DUF4939"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16297">
        <property type="entry name" value="DUF4939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0229">DNA integration</keyword>
    <keyword evidence="16" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="19">
        <location>
            <begin position="1214"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="18">
        <location>
            <begin position="1515"/>
            <end position="1574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="281"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="298"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="SGY91603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1613" mass="180900" checksum="17F2B05CF4915761" modified="2018-09-12" version="1">MIINQALLRDPQPQHYYVILVPRLLKLVTSSPTPLDSSFPVLPTSVTMSSNPISIEELQAALAARDAALASRKAEIASLHAEGHALQQTYQAVLDNFNIVKKLTDTLQHTPKPKSPLEKPPAYDGKDKTAYSTFVSQCKFYIYGNPALFTTDEAKIAFMISLLRNSAYKVFKPYIKLANEKRPHFLKDFPAFLEQAQLYLGDLDCEHTITNKLRALTQTGSAAAYASTFFQLSAFLAWNDPTLQAQYYAGLKPNVRNMLNLQDDPTSVADLSAKAIKADNRLHQSRQEAKATAKPHSQHSQQRGNSASPPTRVTMNGTTQGPTPMDVDATTTRRVPLTPQERKQRLKNNLCLYCGEGGHQHFEKLERPLPSCTHEDITHAHGIARSPPSPVYITLASTLDTQPFDHLVLPLDFCLEPPISGSTLIDSGATSLFIDDSFVSRHGLVRRPHSTPIPLLSGVEYPLFVIDGRPIASGHVTHFVCLTITLGGHSQVIQANVTQLGTYPLVLGTPWLRLFNPSINWADNTLTFLCSQCTLGHPTSVDVSLQGLPLVHSAPDLALDVTLVSSDAFDQSLVDEPYLGPINRDPAHSYLLSTSEEASPSVFPVGPPDSAKYLDDLRSALPSEYHHLLQAFSKAQANTLPPHRPFDLAIKIEDGKQPPFGPLYPLSEKELQALSTWIDENLSKGFIRPSTSPAGAPILFVRKKDGSLRLCVDYRGLNAALDQLCLAKIFTKLNLRSGYNLVRIKGGDKWKTAFRTRYGHFECLLMPFGLTNAPAAFQHLMNSIFRNLLDVTVLVYLDDILIFSDLPSDHVVHVQEVLRRLIDNRLYCNPKKCEFHQTSTEYLGFIILPDGVSMSPSKVDSITSWPTPTTLKELQQFLGFANFYRRFIQGYSRIISPLTCLLKKGAVFDFDSLALAAFNRLKSLFASDIVLRHYDPSLPCVIESDASDYAISAILSQSVDSQLRPVAFFSRKMTPAEQNYKIHDKELLAIVACMRLWRHYLEGVHHPITILTDHNALHYFQTTKVLTRRQARWSETVNHLNYIIKYRPGAQNNKADALSRRPDFAAGGKACEQPGVVLLRPSSISATFSPSSEIADLIKSRLLHDPASLRVINNLNRDASLHPDFALQDGFLLQHHKIYVPDFELLKVKLLHQVHDSPPSGHFGQAKSFELLDRNFVWPGMRAFVNDYVCSCDSCQRNKPSHHRKHGPLHSLPVPTKPWSLLSMDHIVDLPPSSGFDSVLIVVDRLTKEAHFIPAQKSDTSKTLASQFKTQIFRLHGLPGDIVSDRGTTFTSSWWTEFLKMLDIRPNLSTAFHPESDGQTERTNQILEHYLRHFCDYRQDNWHDLLPLAEFSYNDSFHSSIGMTPFFASRGYHPRLEVTLQETPVPDVRQHLAGLCNAQQLAQDQICCSQESHACYANLCRAPTPPFVLGQKVMLNRRNIRTTRPSSKLDSNKLGPFVIKCIINPVAYELDLPSTMRIHPVFHVLLLEPYRPNTLPSRQQPVPPPPNLIDGQEAFVVKRILDSRVRHGSLQYFVNWTGYGPQDREWVDASDFDDDDALVLDFHRSKPRKPGADRIQHLAELDALLRDPQPQHYYVILVPRLLKLVTSSPTPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJA8</accession>
    <name>A0A2X0MJA8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C010g05924 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C010g05924</name>
        <name evidence="10" type="ORF">BQ5605_C010G05924</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJA8"/>
    <dbReference type="STRING" id="796604.A0A2X0MJA8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07331">
        <property type="entry name" value="M48C_Oma1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051156">
        <property type="entry name" value="Mito/Outer_Membr_Metalloprot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726:SF18">
        <property type="entry name" value="PEPTIDASE M48 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="9">
        <location>
            <begin position="300"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="511"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="511"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="528"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY13637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="544" mass="61560" checksum="69008469B9A9810A" modified="2018-09-12" version="1">MLRPGARSLWTIEFGNWSPSHLQAGCPGFPTWTAFRFASSLGSSTTQMRTYHHSITIYSRKWTRPLPLLLLPSGLAQRIHSARSPVSGPRTSQQLRGFHATRPHRDILFVSLSAFKAALLTVVRVSLIFLPVAWRWGMFKRFPRGAWRLGGIPLVATCLVLALGLNQSDKTARWRLLLMSEREELAWSNTRCVKILPSGLSNPDLLRRSRAELYSSFTSVEEIISNDQCVLMPPEDPRVEPVRRVIERLVQTLNDDAPLSFAQYLQEEMGSKVGSKESKRSKIVPSARIEVANMPWVPEKKMKKGTWDLYCIDLPKINAFVLSSKDFFVYSGLLSLVEDDENLLAALLAHECVHLTERHSVEELGFLALSGVVFDILHGTGWALTLCFPMVGDALSAFFTFVDRKVGQRAYSRKLKTEADELGLELMARAGFNTHASITLWEILNEVEQDVQERGEHGKIIDDIALLRTHPSGEQRLDNLKKHLPAAIKLYEHTLREKEGQLAAEHRIREEEAEHHRIQLEEDEQRRAAAAAAREGQQQQKQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJW8</accession>
    <name>A0A2X0MJW8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">BQ5605_C035g11433 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C035g11433</name>
        <name evidence="14" type="ORF">BQ5605_C035G11433</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000064">
        <property type="protein sequence ID" value="SGY97934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1710">
        <property type="entry name" value="Subtilisin-like superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010435">
        <property type="entry name" value="C5a/SBT2-like_Fn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF66">
        <property type="entry name" value="SERIN ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06280">
        <property type="entry name" value="fn3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015897900" evidence="8">
        <location>
            <begin position="23"/>
            <end position="1823"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="9">
        <location>
            <begin position="200"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="C5a peptidase/Subtilisin-like protease SBT2-like Fn3-like" evidence="10">
        <location>
            <begin position="637"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="12">
        <location>
            <begin position="1205"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="domain" description="Retroviral polymerase SH3-like" evidence="13">
        <location>
            <begin position="1465"/>
            <end position="1520"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="11">
        <location>
            <begin position="1727"/>
            <end position="1823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1521"/>
            <end position="1607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1627"/>
            <end position="1653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1527"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1548"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1561"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF25597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGY97934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1823" mass="199025" checksum="DF2DFA667F3EA743" modified="2018-09-12" version="1">MKSFQLALLATACFALAPITSGATSASYSISPQIIPGRYIIAVGGSSSTLSKRASEVCWRNSTRQDELKEADDLRAGDFNLGHAISGVISKLNSKGINVETKKVFQSPGVLTGASISVPESTTAADLLAIPGVTHVWPVRNIPHPHSFTSAPRGIVGVENEKVVRRHLLQRRANNDFENGQFPPHQMTGVDKLHAKGYLGAGIRILVIDTGVDYKNPILGGWFGKGCKVGFGHSFVTDKGTPTSKPDPYTNCSSHGTHVSGTIGANQNKYGFTGVAPKATLGMYRIFPCSGPTPDDVTVESLLRAMEDDVDVINMSLGSPSGWMGVSSVEHVVQKLIAKGIHVVTSAGNDQSEGMFYANSPTASQDGISTASVEVTVVPAYNMVFNTRGYPSMSLFSARLLGVDHPMPLYITSTDLNVDNDACEPLPKSTSSLRNHVVGVRRGTCYSSTKLKKLAAKGARYVIVYGAEGAENDPYFTADGTGLKAVGGMTRADGVKLIKYYLTQEKKGGLQVTLPSNSKQLRVEQTLSSGEVSEFSQFGPTNDLYGQPSLAVPGGGLYFDGLSVRCGLCALILAARKKDNFTPIEMRQLLSSTSKSIPVKRGTKSPLTTVVLQGGGLIQVDKAFEAKSYFSPNELYLNDMAHFAATQTVTITNKNSKAVTYRYSDTGAQPRLVYDKKGQYSPSLSPVTILPGKTSTFQIKFQPPQFSAGQRSLFPVYSGFIMITADNKESFQIPYFGFAGNMGDMQILDQTDRFAGQTEKGLRYPFIMGDDKTPQLSPTTVKTYKMESGIAINFRLAQACRAFSIDLVFANTTFKPTISPENNADLSRRSLEDGDLDLDQGFLETNNPLEDSHLAPRFLANTLFCARAYLCLCSLLKQVMSSTGESDFPNGSGNCLYLKDTQGYKSWSQRAFINLRADKVWDVVNQSIDSLVTDYRSTLVIAHATASVAPVEPASSGFSGLGGDSGSAHSDASPRLTSVQVADKVAKYRERAIRRNDLACKYIANSISEEQMSHLIHLTSAYEMWDTLRAQPYSGDIPFKEFVNKVKIAMTDFQNLGAPLPHWLFAGMLVRSLPAQYDSIVGNLASDIDIHMDWNTFYPKLLMNVEMADSRNKQKKSLSARIVDDTSLVARISTTAQKDYSKSYCSRCKALGHERGWRLCPSRNKDASAPASSDSNSNVAAIGVDESALMTYTFPYSRTMPRFPWIIDSGAKVHCVGDKSVLSDVVSEPLKIYVADQSQIESPGHGSVTFLTSYGARITIKRVYYMPGAQCGFISIDRLLESMTRFCARFLVRGFVMDAAPVQPIMSSSPPSMVGANRLTGTCTLMEAHRKLGHQSPAAIVLAVKSGAITGITLKDEKVTPCFSCIQAKSKRSPFSNKSTEAPHALYRVFIDLGFVEHPNHHGDTIYLAIVDQYSTAKWTIVLKDKRAECSRATSCLSPRIQGKTAIEVLLGKKPSLAHLQPFGSTAFVHVPKERRSKLAPRSIQGVFIGYSGEYNYRVWVQSSKQVYVSRHVTFLETPSVVTSSQDRADASDPVHHSQPPHPPPDVLPSTPTSPVVDPTLPDPQPPPVVPIGVGQQGGYLAVVPRKDDNNDNNDEPDNYHDTEEPLDGEAEVALAPREGYAIVRTGPNPGQFENVDPSNILPAGSRRRPQPPENILPIISAIMVNVSDTPPMFHDKLSYDAYCAAMFAEEDIEIPKTFKEAMKSPYRNHWSAAMVSELLQFDHHGVFQEVKWHKGIRVLGTIWVYSIKRNANGKIIRFKARLVAQGFAQRPGIDYHDTYAPVARSSTILFLIALAVAQGLYLEQFNFDCAFLNGKMTEDVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MK72</accession>
    <name>A0A2X0MK72_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C013g07076 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C013g07076</name>
        <name evidence="3" type="ORF">BQ5605_C013G07076</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY14743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MK72"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1267"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="650"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="711"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1846"/>
            <end position="1871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="713"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY14743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2090" mass="232086" checksum="8F7DD65547E6188A" modified="2018-09-12" version="1">MQTGDPGSAPGARAPPPPASAPTSLPIAGTKETQATQVAGRTATYAAATNSSVVSNETPAQQQDRLARLQALPGILAAIQAVPGNRADRFVQAIFATPDFPSTVATALKFSALNATRNIINPFANALEVSLSHKSTGRASATDKGELVACVRTLLSPNTPICFDTGVPLSGDLEAFMPRITGLQHSSTFRTGVLHHRITVGFVSAEARDAALASAPMLVWNSANARFAKAHPFHRNMLEMRINVGVVRPPSKEQIVAAFQSIVQQLSTKGHSCQLVQVLRVIHVDTAKAYAHTVGDFSAFIHFDDASLFQHPTTTLKEILPSRMDLPTRGLDVTAVRHDYEKEAPCARCHFAGHVERCPLMQAANRKEAEDLARHAVMRGAGMVGGGEQTGVGRAATTTTNNIRPTANNNNTSEVVAPSRALGTDQLESRNRFAGLEVEGGQEDDIEEEVAGKEGEEKEQVEEGDEDTGAKADDEDSDSDGNAGAGIDKAGGDGKDDDKDNDEHDDKDEQDDSSEGSERRGDDVMKDGAEEEDEEMETEVEEEVEQEQGVQDDSIMIIDDGQTTITTVSRESTPRSPLWPPLSPETLAKSLREGAEWDRANAEAAARVQAENEAIINAQLDAQEPLVRHQFAEWGQEDGQLRFINIRGTGSRSDKKMKRSQTVADLSDPSDDPVDVKRVLNRVKGRAGKEVAGQGKRVTRSMSAAAAMQVEGAKAKAEKGKGVEEKRWSDHEPEDDILPEFPLFEDNITAKSTWNVRRCMGIPEKRRDIYTYLSTFKASAILLQEHFIKPELWQCIKDEYEGKAFISKHCLTLIPADSPLIDAEILRTHSALDGRILVTSFRLRGDIRILEINNLYAPVDTKQRLTFFDKLHFHRTQSTHLRLLGGDLNDCPLPAIDRRNQGRHGHHWPILIGKLDSPYTDCIRFKHPLTPSFTRPNIVRKRPKSFSRLDYFLLQRTHQKRLVQASTIYDHPKDLSDHRPVSIVLVLSDERGDAAQPNNSLPTTSNQLHRINAATFKTAAFQGMLEGWLEGASGEEPVGELEVVLGNCEKEGRELARREHRERVERMAVLVGRVQDLEALPVMGDEETAEWTRTTEELRRAVNERARQLRIRAHVPEIAIEERLSRPVHAKLAARSSDSKITALRLPNGELTHDIDVALDHTQAHFQRLYDLEPRDRDHVERLRDDFLAPIRAARTCDDPSSDPLFLRRLSKAHIELLQQPITEDEVVAAIATTHPDRSPGPSGVPYELYHTAPRAWAKALSRAFNAMTERGSLSPRQGQGLVRLLFKHHKIGADRAELSSYRPITLRECDYKLFTKVYVARLNHVLPDLLPPQQHGFVKGRRSADASFHLRLLIEELGARGTEFPDAALLSLDQSSAYDLVEHEWIFAIFDALGAPAAFQRVLRMLYSGDSTSARYIINGFLTAPVRLTCGLGQGDPASSSVWDVVFQPFLDALHRRGIALNLSLPTIHPYPQSRAITSLAFADDVVVAVAGSESLTLLDDLALDWRLATNGRLNTDKTVVLPIGCRWEAGDRPLVVKAEGESLEWIGLSFDPTGNTELANVNLVARLEAVLDSARDRGLTHHTRAFYVNRYAIPKILHILSADIPPLEVVKELDRILVDFVRGGKRRSCYGKDVVFTPRFKGGLGVMRMQDVVDSVAARVWDVLLGGSDAIWQGLARAAIVRAHPAPDFDLATDAWPCDYTPIRTDLHPRWQAVLKVPSTHNAQVKPRTLTLANLLALPIKLHTLHYLPGAPAVSRSPYDVDYAAFAIYAKVADLFRRELYPGGGFHLWTPPTDVVVSNSEYDQRGRPQREHIVAWYRHAINRLRFTPIAQPVAAVRINGPPRVRPRSEVRPTTPLESILPHPIDPPQRLPRPALPDQSTQYNLLSMDRPYTIRRVRRVLNAKAFTDTIGFRDSLQPDDLKGFWKGVNSKALTAREREVWFKLVRNFTPTRSLQFHQKHDDSPACLVCGAPKDDREHYFFDCVDSGNVWIAARSVLCDALGLDTIDNTHYTAVQRMFGLPKLKASLRDQEGAGRTIEIFTGLVLEMISSGRWGMQKWGTRTEGVGRRRIILEERLKLRAGGAWGRRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MK85</accession>
    <name>A0A2X0MK85_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C034g11338 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C034g11338</name>
        <name evidence="2" type="ORF">BQ5605_C034G11338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000065">
        <property type="protein sequence ID" value="SGZ00299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MK85"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ00299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="246" mass="27485" checksum="00E056C06F5A72C3" modified="2018-09-12" version="1">MSHSSQPEQQTDSDWMPYSRPSKTEDTTERIFDAVEFRNKNLHLKFPSVDWSEARLVAEGDPEWGMEYLSPPQLLPGLPCLSASSAVPMTAEELQKHLDREEAGPAETPDIDPRRNRHLFVDSGGNKWIRAGVVYSQELPPAYLNFKDQDGARRFYTKTVRIESRMTVACTEDKARIATRSDFDPPIASTSATTLNRDVDIVPTPTRALPQPTPSPAVASTSAYTSDLVRGKLYFSAFYVSTRSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKE6</accession>
    <name>A0A2X0MKE6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C002g01345 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C002g01345</name>
        <name evidence="5" type="ORF">BQ5605_C002G01345</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY32290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A2X0MKE6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="248"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY32290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="285" mass="31439" checksum="D93973A9B2007204" modified="2018-09-12" version="1">MSSGTRDGPPHTDNVARRVKLKLPTLNAGFKSRDVTRWLAGCEDAIESAEWNYGGKIAAVHLIREAGCKMEGEGADWYIDCRDKVKALKSWPEFAQEVKARFINEKTGLEAKHAFYNAHQTGTLSDFVATLIAARGQAGSIGGTQVISDELFKDHLLHRCDELLYLRATASPLFDVAKFTMNQLVAYLQSLWEAITLERATTGVRRMGLRNDQVRQEQNNSAAHQTSGRPMAGLDRTPRDKALHEGCCFHCDVHGHIAADCPSKPGTSLTPAPLRPTPGPQMCRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKX3</accession>
    <name>A0A2X0MKX3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C030g10878 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C030g10878</name>
        <name evidence="2" type="ORF">BQ5605_C030G10878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000069">
        <property type="protein sequence ID" value="SGZ09495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MKX3"/>
    <dbReference type="STRING" id="796604.A0A2X0MKX3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="479"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ09495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="763" mass="82546" checksum="EBE81779CC67E7A6" modified="2018-09-12" version="1">MPATSLNLPMRHLFSCTPHTWFEPPPPGNAPDYSTAPRLQANAGTAFDCAARSGGLRWGDYSSPGDRIVDSFLSLLDLHPSLLELFEAKIAVIEAMGSTRARRRARITKEEVRDAFTSIFAGGLEGATCELLDHYASITEENFTPTTSGYWVTPSSFQGLSYRTRGDAILEIGRGVDDSAVVVSSIAIEFKRGPVHHTAAKGPPPSGTNSAIPVLDHASPVPLQNLETQVSVGPDAIATKAIIQCASQGCRFFLLFSVPFFQIGELVEHQPSDAARASDAAASTASASTSTAPMPGTPHSSTPTPPTTTEASTPPAVRRQYSLLLQELVRWVERYPGTSLQPAETLGVDLPARSFIVSFIALAFTAVMKVPEPGKASVKELLDAIPNTSNQSRPRADSDSDREDPSYEPANKAPKTSAIGPGTRSSRRLAGDPPLTQAKGSNRPVTPPVSEEAGSDLSSGALTPEALCFSSPPASTDRSPTTSPASGSVPSSKSITIAHDRNFVIQASLSNAHWSMMSYTGTSRVNLVEIDFDIVSSDRSDSPLSSLLSSNPSPATDFIRSLHLSDAVLQWLTEDPKDELEDDRIPLELLGYFEAAADLRLEKQVGTGSTADGYLANVVRVNPRWSSPANREVPLVGHPAPNTRYFLKLVTCNYVGSVVRETLFYQHVFPHLRDRLQKHLPQYHGTYRGINGNGYAMVLENVGTHMNYSEFYERSGQWQEIEKAFVELGIVHNDIRQGNVLVRPDGGGFCFVDWGRSYLKLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKX7</accession>
    <name>A0A2X0MKX7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BQ5605_C002g01515</name>
        <name evidence="16" type="ORF">BQ5605_C002G01515</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY33607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MKX7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901992">
        <property type="term" value="P:positive regulation of mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05611">
        <property type="entry name" value="STKc_Rim15_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000340">
        <property type="entry name" value="Serine threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001008">
        <property type="entry name" value="Serine/threonine-protein kinase cek1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE GREATWALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="14">
        <location>
            <begin position="1741"/>
            <end position="1814"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="2215"/>
            <end position="2576"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="15">
        <location>
            <begin position="2577"/>
            <end position="2708"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="13">
        <location>
            <begin position="2950"/>
            <end position="3065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="86"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="342"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="443"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="587"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="659"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="746"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="962"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1000"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1087"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1176"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1312"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1430"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1510"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1706"/>
            <end position="1742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2371"/>
            <end position="2410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2430"/>
            <end position="2457"/>
        </location>
    </feature>
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    <feature type="region of interest" description="Disordered" evidence="11">
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            <begin position="12"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="27"/>
            <end position="56"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="86"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="11">
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            <begin position="131"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="160"/>
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            <begin position="266"/>
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            <end position="607"/>
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            <begin position="1238"/>
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            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50112"/>
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            <dbReference type="PROSITE" id="PS51285"/>
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            <dbReference type="EMBL" id="SGY33607.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
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    </evidence>
    <sequence length="3132" mass="331360" checksum="16AE9F7DBD23E3E0" modified="2018-09-12" version="1">MAQVPEDDSSRRTPGTGSNSTTQSDLGIGTAAAAASTASASGSTSDSGRSNSATSAIPLRLLTPAPSSSTESAAFSSLTSTFFVSGSPPLASPPLARAQSLRSATSGSSAGAPSSSSSRRPHLASRASSSETVSRLSPLSTVAASSSSSSSSSPLYRAGSTPTSSTSSSPPPSSSSSSSSSPPSITSRRLSVATYAGSSVGSTRRSRQGTVSAIVSSSASLTDYTTSLESGSESESGHHIGPHVTGMFSPTHDKASTSSAHLAPPSSVSSSFGGNSGSSSSSSLLTTATTKRSPLATSTVVTTNLLTPSPLGLSESSHPSSPSQAISIPSATQSVPAVIAPSATTTPSSVRLSTTPLFPSPLAQASGPEEDGEPSKGDEDGDEEAIDDEEEEIGHRGGRGALGGGRAGSPLVRENLAPFGDIDISPTLSIVALPDINAPSLQGNLSSTLSAPRVRSTTAPNATTHHKRSPSLVDSSSEHDLARNNWTPRVRSIGRASGLPVSSAVSSPSQSPTTPTDDLGPRRRSRLFDVTSSPAGGNASSSNSTPRASTSAAAAAFAVTSSPPSPSMSSVPANSISRRASINLVSAPRPFAPGSPTSSRAPNRSQLSAQLSSPYPAAPPPAESIKLTKVPESVRSAIDFRPNLLTQSPVGSASDGFTFPTLENALPRTPSATRAHSPASASGSASPAHSENRSRLSSNPSSRPGSRPISRRTSLDRGHHSGPSPATPLTASSAFAPLFPFPSLPPSASTSSAGRSRTKSAAQPFSHALSSSPFDMTGSSSLDEPQHDLGVSPLSAALSPFAANAARDALLSPELLTSISQRQIDNDWAAPSSSLRVTNYRMSIVPTNIGSGSGLFAPESSTDEYAQIIVASRAAKMRKWKSSSGSHPGLARGSSWLSDLSLQPRSQATDEEGLASDAEIVERDITRFEGESEGGNGAQVEWVDWLDEYERMKAAKMRAEQQTPALGAASEAETGGELVDDKGKGKAREQYYPFEATTAAMTPSSPTHSLGPPTTPGLKLQSMPSELSSSSIPMKPIASPLPEPIAPLIRTASTLSTNVGASPGGKRRRSKLGFKIDTWWSAVRSSFSPLSPTDQRAPRTPSDQATSPHTLEPVASRTSSQFTRPQTPKPALRTASSAQDLSARAQAASNMYQSRFGATVPAGALAPGVRFVASNRLQPPKPAQHDSSGSDPSSEGGDPGSETKRKNPRLSLNLGPAFSTLNRDVRVRTYSQGTKPKSASTDSSNSASAGTSHRFFSPISPIGPPSAESSKSGNYSSTVHTQSGSVSFSPMYWDQTPALVPTSTQFPIRGLLAPTDPLPTAVEDKRPKPPAATSQTPNFSMHSVRHTIRSRLSAAKENCDKELRRIIQGITAHVETELHRSDEAPSTAMIGGTAYEDGRFGDLVVNEDAMFAGGLPYDIDSENEAAIDLNDGDDIANTDSDGATSRPSSRTSRMRTPMLSTGAPQPRRPSMTQAAKSPRRASLAPRKRYLTAAPRSADLSAVSLSLAEGATKSGSGSAHSSRSNSRSRSPLPLQLRNASNGSRSPATSTTPNAAHFRVAQPAFIVLLQEIITVATEILDTPVSKLTSNPHSCSDFISRVQQIGKAWDDNPELACRGWYVQLLLAVAGLSRVIEWWEAERGFWSFSEGDDADAEPILFVTKPTAEESPEVRARGDSCSSSAGAVLAAANTMPEGIIGCAPRWSPLGIDLGEQSANPDDSEPTQQQFDDVDADATSEDAAEAHHEDLRQTVEQIRSSTLLMELTLDDQLFQYLSSAWQELVGLEPAECLNFGIADFVFPEDAAVFAEATRQLEADDSHTVEVNFRLRVGSSSQSSDDEESPEDLYEAMEGKGMLMLDGMTGSPSHTMWVVRPAPLADQTDDPVGETLARFGLDTKHRRSASDPVAYQVPNPRLAIETVLCRICERATPIWFFEKHNETCNETHRLEGDITDCNDRLKELARTIDDVAAAIDEASLENVAEYRGIPLLQSSANDTPPSYLEGLKSPLGAAASARPGPFQVRKAQHKTLDQIYDILQTALSISTPSVLDETGDIPIQDQRLLSPNSESNLAAVMRWQRPVADEAALVRLVQDAEEQIRFKLNTVNRLRNTILYAEKVRQEWEARAHEALAAAKEEARSSPFGSPALQPFPSNDAVEALDIPEKDRVRRHSSLYGLTSPLLSPQDSLGGIGSPLGSSVLSPRIPSGVPSSRTKASSIKDFKILKPISKGAFGSVYLAQKITTGDYYAIKTLKKSDMVAKNQVTNVKAERMILMTQTESDFVVKLYYTFQSKDYLYLVMEYLNGGDCGALVKNLGELPEDWAKRYIAEVIVGLEYLHASGIVHRDLKPDNLLIDSKGHLKLTDFGLSRIGLLGRQTQMPTARGRGFEPGRDSLRSLSRDPALSQSSSPSSTPANALGQSPASYFGSVAITDSFSLDTPASERSSGSGDQASNKAPAQTAANPYVDPLTTSRQEALVEPPQKFVGTPDYLAPESILGVGTDACVDWWALGVICYEFLYGVPPFHDETPEKVFENILSHRIEWHEDLVEYSPEARDFMERLLSTDPSCRLGRGGAAEVKAHPWLEGIDWANLLQGEVKFVPNVTDPENTDYFDPRGATEQAFTDEDTQPDEVKTVAATSSTSTFKDPMLPGAQPTVATNLSDIKNSVSSSGARSIGSNSTSTSRRLARERSETEPSPHDDFGTFNFRNLTVLKQANDDVIKKMRDEQLLPPTLSPLESPIMHNRPLALAGGKTSRSRTTSVDFRGPSSPSSPSASSSSSVPSRQTAPSSPYSLQSSHSRRASEVPPTGAPPTAIDRLKTRQASIPTVGPGGTSGHSRRNSLPSRLRRTSISDSGRCLPSEHSLPNERRRTSAQTASSSKSLLEDTQESASPPSLEEEVPDTSANATTNANAYSMLSPPAPTRAIQESTSAPVPTAPIAAAPIPATPVPSSSSRANTIDCLVAGRNPIVTKVLETMLIRLGCRCVVVYNGGDAILAAQGVKFDLIFLDIQMPVVDGETAARMIKSTNNPSQNTPTIAVCSHAGAVDNQAGTLFSGVLPKPILKADLLRIFSRLGFRLEEKPTRRGLSNSVFGNEYRRGSVNDPSSSRRESVTAGSVAGMSDRRRSSGNLLNPPSDERRGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0ML55</accession>
    <name>A0A2X0ML55_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C032g11100 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C032g11100</name>
        <name evidence="1" type="ORF">BQ5605_C032G11100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000067">
        <property type="protein sequence ID" value="SGZ04950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0ML55"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ04950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="553" mass="62291" checksum="3A8A8B0D88C2A9BE" modified="2018-09-12" version="1">MLQRAISYDATAAATSKVPSSDDTAVQILIDLWQFFDRIYVSKKHGAAKAFARAFSDAVFIPNAGDRLLMEARLAKFGMTWEEAVRSPVWNKKLWRRVRQWIPPPGILEPLVREVFEKLGDSERPSIGSSWHRAVHRPWALRGPDGKADDGVRLYSCQRDTNSLEGGIHRNLRQRFPKSGVSPSHVNACMADYVLVHNLTVSPTPPSQFEETATFLTHYPLYSQVGTFNRTGKPFVGHYDLWLTVELHCLRRKTSAFLPRHSTTVSDIVNPLLYNPSTETFGIIPVQPPTAQVRFLIEPYHVKRGTLRLEPVKWSPRNLLQNNTPAIQHMQRRLPTDRKLRHDWLVERQGTRFAVLHVHTPSERALYRYLSSKVRLGAPQNRRIFEITEPWNKYANGLDIFYKMPEHVNTWAPRWPSLANAQATMNMGGNDVIVIQALLTDPSRGRDVSMLAAKPLLGHKPPVLGRLTEVQVDFSNPPTSSILPFVATASSDAGSSANLGTSSALTRAGTTKGARHCRLCGQTTCRRKASKLSDDGSTRWIRTTHNHEVSVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0ML96</accession>
    <name>A0A2X0ML96_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C023g09666 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C023g09666</name>
        <name evidence="5" type="ORF">BQ5605_C023G09666</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ23937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0ML96"/>
    <dbReference type="STRING" id="796604.A0A2X0ML96"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF17">
        <property type="entry name" value="RHAMNOLIPIDS BIOSYNTHESIS 3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGZ23937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="270" mass="27984" checksum="52AFE1C24CDA2BDD" modified="2018-09-12" version="1">MSSAPSFSVKGKVVLVTGGAKGIGKMITTGYVAAGAKVYISSRDKKSCDAVAQELTKLGPGSAHSIPADLASYEGVEALVAELSKREKHLNVLVNNAGNNWGAPLEEYPDAAWDRVLGLNLKRVFTLTQKCVPLLLASLPKDAPEEGPWNDPARIINIGSVDGIRVPSLETYAYSSSKAALHQLSRVFAAQLGRRGVTSNTIACGPFESKMMAATLEAGRDLIVAGVPLGRIGAPQDVSGTCIFLSSPAGAWVNGATIALDGGALVGGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-10-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLY8</accession>
    <name>A0A2X0MLY8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C024g09928 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C024g09928</name>
        <name evidence="8" type="ORF">BQ5605_C024G09928</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UbiH/COQ6 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ26501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MLY8"/>
    <dbReference type="STRING" id="796604.A0A2X0MLY8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018168">
        <property type="entry name" value="Ubi_Hdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010971">
        <property type="entry name" value="UbiH/COQ6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051205">
        <property type="entry name" value="UbiH/COQ6_monooxygenase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01988">
        <property type="entry name" value="Ubi-OHases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01304">
        <property type="entry name" value="UBIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="48"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="424"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGZ26501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="472" mass="49961" checksum="99E48D499AE09B4C" modified="2018-09-12" version="1">MNYASSSAPRLLVRSLSRKSVRTRAFSCTPRCRAAAAAASEASAEPHDIVVIGGGPAGCTLAAALASNAAISSTHKVTLLEASSMAKLAEWAPNPDEYSNRVSSITAENVAFLSDIGVWGHLDATRARGIEEMQVWDGLSDARITFNSPTLDPHDPFSPHSTAPIASTSSRNPNIAPMATLIENLNLQRACMRALEGAKNLDLVDNKKVLSITSDSSGWPIIEVGSGVESETTRKLRARLLIGADGFNSPVKAYSHIESFGWAYNSQGLVASLRISPAEMGIGMTTAWQRFLPEGPIAFLPLSDTASSLVWSTTPELAKAIKQLPLDLMTRLVNAAFTLPYASLSSFLSLLTSASRPTDAELSDSLEALVAPLQAASVYEVDSIPDESPPKIESIQPGSVAAFPLRLSHADSYLGMPRGGRDLRTALVGDAAHAIHPLAGQGLNMGLGDIQSLLKTLETTVQNGGDVEYVQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MMQ1</accession>
    <name>A0A2X0MMQ1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C021g09269 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C021g09269</name>
        <name evidence="2" type="ORF">BQ5605_C021G09269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000083">
        <property type="protein sequence ID" value="SGZ20370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MMQ1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ20370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="101" mass="10958" checksum="0D3DC2ED2F297889" modified="2018-09-12" version="1">MCLEATCENCNQLTCGASPQRACSTKRASLLTTYECLDFPYRWPGYVHRWGCGGHIASVMDKIPDGKQCKCDQPGGPGAKPRKPSTAPAGKVDVHYKGPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MN95</accession>
    <name>A0A2X0MN95_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C029g10711 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C029g10711</name>
        <name evidence="4" type="ORF">BQ5605_C029G10711</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ15916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MN95"/>
    <dbReference type="STRING" id="796604.A0A2X0MN95"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ15916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="174" mass="19297" checksum="46E14ACAB60B5DFC" modified="2018-09-12" version="1">MLLTITDRLLGYTRLIPSLAADTTKDIAERFHEGWHRFFGPPTRIVSDRDKLFTSHFWRAYHNLMGTRLAMSTLFHLETDGRSKRTNKTAIQALRAVVNKQPNNIRRSPQLSGEVESQTEVMRRKLRNKKGARAGIGPAAGEIAGALRQSHASKSPPQGGSLAGVHLNPPAPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNG9</accession>
    <name>A0A2X0MNG9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C027g10431 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C027g10431</name>
        <name evidence="1" type="ORF">BQ5605_C027G10431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MNG9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ28737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="56" mass="6393" checksum="BDD077ED0FB32C38" modified="2018-09-12" version="1">MLSFVLLHLEPLFRYDSREWSGESTELAEGHVPGCFDGKWNLGERRRNGLSLADPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNL6</accession>
    <name>A0A2X0MNL6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C059g12710 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C059g12710</name>
        <name evidence="3" type="ORF">BQ5605_C059G12710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000090">
        <property type="protein sequence ID" value="SGZ29024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1061"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="449"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ29024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1854" mass="203265" checksum="5D95E32A931B7235" modified="2018-09-12" version="1">MPDPPGAQAPPPDNPLGGNRASDDESLNTLTREPVTGGTANPPAWSTEATQARLDCEKVMQNTFRVLGIVPSGKSTRRLMVLMHDASTPPSQAPLLARAAQRAVRNDAAPASNVIRVIMDGPGSPRGPVQIALRKHFGLAETPFMFARPEGVVLDPEVEKLFSKCVKLNPIVTKATKRFPIARHMYELVFESDQACLEAAAAGPFSHHGKEMVTELPSASPLNHVVQVRFTLPSSSSATPASVLRQSLDDALTLSFGRAGRTQGYTLMQLQRGLAVDPNGDPMAMTEDGFHCAYLRLHADLFQGSTETQKAALNAALPREIEILGAKYGLRHEFETHYCAVCDRAGHQWGACRKPVSTPATAAPVPGASTSTSTTGFRVAGKNGKHGGPAALNSRASGTNMIQLGPRANPAGAATGNKDDANDDDGGGESVASTEPEGGDTGKETLTRATTGPTKETQTTTAAPVSTPTSPSPSASAPASPLSGGTSESSATSTTSIASTSPRRLRSSSAPGNRRVTRAGSAMILGASGGDGSGGNSSGVNQVKIIRYLKTLRPAPAAILLQEHHLGYNASREGFESAWPGACIRFTPHVLTLIPDGSPLAGHLLSSTPVVFAGAPRFDGRILRSVFRLEELDVEIINMYAPVQEDDRRDFFGLLHFNAPRPKTLRILAGDLNDCPDVSVDRVSITDRAWTPVSHWQTLLSKIAFNALDTVRHVHSCTPAFTRPHYRGRGEERKICSWSRIDYILVQCSWANRLLSASTLFDAPCSDHRPVVATFALPTSNADAEPPLSLPSTSDFISRLNPTVFDDQDFVASIPGVVDEVYRRLEGTAPLGDVYDAALRAVAVAGHARYRSTRADMRRLRAESQSVMEALEARGEHMNEAERDAYAFAKSRLDQLAVKEAQWLRIRAHVPSVDSREGQSASIRTRLNRRSRQTSIVSLEDVDGTETVDMQEGLGIASRHAQSLFTPDPARGDPTNARRSLLGPIRAAKCYDDDRSDPTFGRRLPRQARVALDEPFTLLEVEAALKKTDSGRSPGPSGIPYELFKALPTYFAPKLLDLFNSIWEGGKMTASLAEGLVRLLPKNKPGANLKSLGAYRPITLRETTYKVLSKVLVARLNGVLGELLPPAQHGFMPSRRSADAGSHLTLLLEKLKSLGTEVFPEGALLSLDQQSAYDRVDHAWIFDVFEAFGFGERFISLLRALYDPETLGVRYLINGFPTELVRLLCGLGQGDPLSCPVWNITFQPFLDALVRRGIALDLQKVWPGGPRAQLTHLAFADDAVVVVESPAALSKLETLSQTWYEATNGKTNTDKTLVLPLGPNWLRDETAQALPTVQEGESFKWCGYAFFRHGDSKLFWTHVLDRIKAKTRAAGDRTLSPSGKVFYANAHIISTVLHVLSFDIPPQWFIKAAETALTDFVWGGAGRNTVARDFVFQAREDGGLGLISIGDIVHSVALRFWDAVAGSNEAIWAPLARESWRSLVAATRDFSPWGFFSSTARVEKLYRDSTRWGAVVAAARVTVPTIKSELLTLPELLSLPPRLPSLYAEGAKHAYDDADAVAKFAQIADLYWRDEGKGWALVGHRRGFWQHSKEPALQHEHVWSRVGQLLKAKALLPKTALRPARIPLKEAPRPRCFNFFGLTRPFTIRKLRRLVNVVRFPGREDRVKRFRDGTSQSDRKRFWRWLHDRFASAVEQDTHWRLMYDVTPTRKRQHTQGHASSPTCLFCGNDAAVIETVSHYFFECAYSTSFWGGVLRILFDKLGIEDTDVDPSTFTPEQLTMGLPLLRGRGRTTSRWMWVRLACAIGFQRLHLLRWRVHQRFELDKVVAPPSLPSALRAFERDFLSRAGFVPGARDWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPR3</accession>
    <name>A0A2X0MPR3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C024g09772 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C024g09772</name>
        <name evidence="1" type="ORF">BQ5605_C024G09772</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ25796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MPR3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ25796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="36" mass="3939" checksum="EF53A9E8ACE3C7F6" modified="2018-09-12" version="1">MATMLLSPGDKDEVNERTALLNHDNLPDHALFDSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPY0</accession>
    <name>A0A2X0MPY0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C025g09975 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C025g09975</name>
        <name evidence="1" type="ORF">BQ5605_C025G09975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000087">
        <property type="protein sequence ID" value="SGZ26858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MPY0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ26858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="528" mass="58809" checksum="313C3ED70B10C57C" modified="2018-09-12" version="1">MAVKKKGPAARGMLVPIRFGVPPQGGHAKRTACVSSPLVELVLDLVQHALSQPTRVYAPGLAITDTEAYLVVLDHEACRIATIADCWGERFGELGVVLSILFGLDVYSAGFNPLFLYACHSQIGITPASFLASCLRPPECKEGAPLVGRTVEFIDEEPIELVHPTLTDGGSIFSRSTVVLQLTRPSLIAPAGSASSPSNSTPSFVLKIQYNTLNYVGHEANVLQKIEERCASIASQEEASLIFNHIALLEKSKSFGLHYSQIQDKDLPVFRDGQDAYQRVRRRKLDLLILRNPTPLPTRVHGHRHCRHPLSDAFNVLDRLFTLLPVLYDLGIHHRDLLLGNILHHRGHLVLVDWDSGIVAPPGVRVRNVAEDCGSVRVTLDTAPSDVLLWLLMGRERTLAFRSLQDDLESAVYWFVQVVGSFAEFLSPPSWEAWKPLYLASTCALPGWKQLFNARLDLWGSVLDRSPRRRYLLEALHKLSPRECRLVNMLTLKLPDFPQSPDGIVRTKAMMAMMQTEMREILGYQSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPY4</accession>
    <name>A0A2X0MPY4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Small nuclear ribonucleoprotein E</fullName>
            <shortName evidence="11">snRNP-E</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Sm protein E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C023g09641</name>
        <name evidence="13" type="ORF">BQ5605_C023G09641</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in pre-mRNA splicing. Binds and is required for the stability of snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site. Involved in cap modification.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ23820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MPY4"/>
    <dbReference type="STRING" id="796604.A0A2X0MPY4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01718">
        <property type="entry name" value="Sm_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027078">
        <property type="entry name" value="snRNP-E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11193">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="11"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGZ23820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="84" mass="9686" checksum="CFA96FDE9846E9E6" modified="2018-09-12" version="1">MSSRKVMVQPINVIFKHLQSGTPVQVWLYDNLEQRLEGKIIGFDEFMNVVLDDAQEVWIKDTKQHKLGQRQPLGAPWQGRVLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MR08</accession>
    <name>A0A2X0MR08_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C025g10024 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C025g10024</name>
        <name evidence="2" type="ORF">BQ5605_C025G10024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000087">
        <property type="protein sequence ID" value="SGZ27009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MR08"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ27009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="350" mass="38694" checksum="1F0A7CA71BC4C10A" modified="2018-09-12" version="1">MNMTIAELLAFDVAPADASLHIELSKDEHTQYSTLSSTRCRRPMKSSDPTRGEAGVGVSNTEEGRSAAHSCVLKGLVQSMGPSRCEDMAGTTRSFRWTRGDQMDRALTTHEDPEKYGALAQRYPHFGSLDGGAVTTTTTSEIGSLVCFGLKRGMHSISCDQTAYGEEVLFIGIVTTNHCNQDTLASLVLLSNVVVQELRLIKKTCYSTHLIDGTMPFRMIDGRQVIESLGPSTTTYRSTTDLTSCYPDERLISTNAHAEQRFAAFGACPACEMPPAEPLQVAQMPPRKQGAQLRQKGSLTTKQRASQQSKEGLFEAWSHAQHQPKRRAPQATFDRPRRARKRSERVFEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MRL4</accession>
    <name>A0A2X0MRL4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C067g12828 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C067g12828</name>
        <name evidence="1" type="ORF">BQ5605_C067G12828</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000135">
        <property type="protein sequence ID" value="SGZ35318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MRL4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ35318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="52" mass="5736" checksum="4107FEC52A0981F0" modified="2018-09-12" version="1">MMGCDYLPTGIKGYRPGEARKFGSVSLPIRYLDPRLRTRHDGPASTRIGDVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MSK8</accession>
    <name>A0A2X0MSK8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="23">BQ5605_C053g12601 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">BQ5605_C053g12601</name>
        <name evidence="23" type="ORF">BQ5605_C053G12601</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000098">
        <property type="protein sequence ID" value="SGZ29875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MSK8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0229">DNA integration</keyword>
    <keyword evidence="18" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="16" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="15" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="16" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="17" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="22">
        <location>
            <begin position="626"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="286"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="858"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="917"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="SGZ29875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1167" mass="128230" checksum="B5562C43F201ED06" modified="2018-09-12" version="1">MSRKAESLESIGLLTRINWPAWAPAMRLALQSISAFRVATGEQKKPPASQPPNQSLKDYTSLCNDYDAKDAKGRTLIRSHVDENTWFKLKGSAVDASLHQVWTGLVRAYETNSVPFVGTKTLRAYWNLRYEPGTSVTSFMTEVEGLGELCNRQKMSFWKQQLGIGTEELQGFYAQIVDILGEERGKALLSMVLHVDDFAIKTVLMEQLPEKYTFAFREEKDVDLFLEKVRTAYDEDVIMNGANDKEQTEAPASALAAARQEADPGQAPPCNGNCACGQQPHAFATAGQHRGHAGPTRNSYRSGGHGRTGTRVGAKTRAEHYANSDKWGKIVGGKFMCANNQCVNCFGFGHRRAACDSRNPTGDRIAFLQSLDINVPVASHGTYFVEDPVPMSLANRMGASFHFTNYAAEVREQTIFRAVTAEAPELIFDTGATTSLVNDKCMLSDYATLDCPIFMIDAAGTRTPAVGRGTLTAEFALADGTTSKMTIADVLHVPNFVVNLIWGPSLCKQGVRIEMEEGRCEFSKDGQTFAIAQLIGSKYIFQARLSNLNPTEAQSLTVSVRSNSADREIWHQRFGHLNMPYLLEMERKETVMGLNIKGEDFDVAKCHGCMQGRGVHANISRGPASRADKPLHAIHADLWGPVRHESFAGEVMVLGLVDDYSRFRWSFPIGKKSSVTAFVVKFIQRVERSRDCNVAIFHSDNGGEFVNNSLKAFFRERGIEHRTTVPYAHYQNGVIERGWRTMFKTVRIWLLVSGLPLSFWAFAATAFTYVSNRRPTAALPGSTPFEMYHLRKPNVSRFRVWGCVAYVRIAPERRASKIEPPRVKARFIGYAEQGWMFWRPDTNTVFVSDDANFDESSFELHRGNSDDADLREDSPTTLFGDPPTGSLDIDGDDAVEQDFSLDGAGRAQAPGTDDRATAPIAARRAFAPDGDSRDNTPPVGRARAPDREYTPAAPGCERAPGNRVQHSDGQELTPIVPTRRAPAPVVSNGRAPAPVAPNGRAPAPVVPNGRAPAPVAGDGGAPPPVASRRPSPFLDDDADNDPPDPNPIPDGYEPVVPTTERTSELAERWGAPAGSRRRGGAEQQAMFVDLGTILGDVIPLNELPEWEQVLSVVVNLEECNGWTNLSSIVQGSTEGICGIEELEAYQVWTGNPDEPTYKQAVRQTAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MTA9</accession>
    <name>A0A2X0MTA9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C045g12213 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C045g12213</name>
        <name evidence="1" type="ORF">BQ5605_C045G12213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000115">
        <property type="protein sequence ID" value="SGZ31603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MTA9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ31603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="63" mass="7285" checksum="4CC99B430F8353C5" modified="2018-09-12" version="1">MCTPGSTQPLQGPWPMDRYPCSLDYINYHVNVDYINYHVNGVEQLQQHQSSPPPAPLWQRSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MTE2</accession>
    <name>A0A2X0MTE2_9BASI</name>
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        <submittedName>
            <fullName evidence="1">BQ5605_C043g12102 protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="primary">BQ5605_C043g12102</name>
        <name evidence="1" type="ORF">BQ5605_C043G12102</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000117">
        <property type="protein sequence ID" value="SGZ32173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ32173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="37" mass="3760" checksum="BCD5F4EAADA8ED84" modified="2018-09-12" version="1">MYQHTVVSAAPACGVGVPIRSHVQALCRALPGARGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MUE9</accession>
    <name>A0A2X0MUE9_9BASI</name>
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        </submittedName>
        <submittedName>
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        </submittedName>
        <submittedName>
            <fullName evidence="5">BQ5605_C013g07077 protein</fullName>
        </submittedName>
        <submittedName>
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        </submittedName>
        <submittedName>
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        </submittedName>
        <submittedName>
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        </submittedName>
        <submittedName>
            <fullName evidence="77">BQ5605_C062g12763 protein</fullName>
        </submittedName>
        <submittedName>
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        </submittedName>
        <submittedName>
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        </submittedName>
        <submittedName>
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        </submittedName>
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        <name evidence="41" type="ORF">BQ5605_C135G13393</name>
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        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
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    <reference evidence="74 79" key="1">
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                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <dbReference type="EMBL" id="SGY11536.1"/>
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            <dbReference type="EMBL" id="SGY11616.1"/>
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            <dbReference type="EMBL" id="SGY14744.1"/>
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            <dbReference type="EMBL" id="SGY14746.1"/>
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            <dbReference type="EMBL" id="SGY15344.1"/>
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            <dbReference type="EMBL" id="SGY16966.1"/>
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            <dbReference type="EMBL" id="SGY18651.1"/>
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            <dbReference type="EMBL" id="SGY19602.1"/>
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            <dbReference type="EMBL" id="SGY20206.1"/>
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            <dbReference type="EMBL" id="SGY20788.1"/>
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            <dbReference type="EMBL" id="SGY27669.1"/>
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            <dbReference type="EMBL" id="SGY27754.1"/>
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            <dbReference type="EMBL" id="SGY27757.1"/>
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            <dbReference type="EMBL" id="SGZ22006.1"/>
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            <dbReference type="EMBL" id="SGZ30072.1"/>
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            <dbReference type="EMBL" id="SGZ30085.1"/>
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            <dbReference type="EMBL" id="SGZ30390.1"/>
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            <dbReference type="EMBL" id="SGZ30510.1"/>
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            <dbReference type="EMBL" id="SGZ30528.1"/>
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            <dbReference type="EMBL" id="SGZ30889.1"/>
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            <dbReference type="EMBL" id="SGZ31951.1"/>
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            <dbReference type="EMBL" id="SGZ35071.1"/>
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            <dbReference type="EMBL" id="SGZ35442.1"/>
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            <dbReference type="EMBL" id="SGZ35498.1"/>
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        <source>
            <dbReference type="EMBL" id="SGZ35531.1"/>
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            <dbReference type="EMBL" id="SGZ35550.1"/>
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            <dbReference type="EMBL" id="SGZ35571.1"/>
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            <dbReference type="EMBL" id="SGZ35635.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
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    <sequence length="66" mass="7553" checksum="81243F2B5B592DA6" modified="2018-09-12" version="1">MVRSFALVKIYGMAREGRSLVSGQYPRVKARLVSLYWIAFLSAPTAQQPALEIQPREDIRRCRGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MUS7</accession>
    <name>A0A2X0MUS7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C064g12789 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C064g12789</name>
        <name evidence="4" type="ORF">BQ5605_C064G12789</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ANP1/MMN9/VAN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000132">
        <property type="protein sequence ID" value="SGZ35164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MUS7"/>
    <dbReference type="STRING" id="796604.A0A2X0MUS7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052086">
        <property type="entry name" value="Mannan_Polymerase_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083:SF6">
        <property type="entry name" value="MANNAN POLYMERASE COMPLEXES SUBUNIT MNN9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083">
        <property type="entry name" value="MANNAN POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03452">
        <property type="entry name" value="Anp1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ35164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="453" mass="51156" checksum="5B0A20108CE9FC26" modified="2018-09-12" version="1">MLRRLSDFATSRRRRGGDSYGGSPALPSSLDNSPQGFRNEFEPYIYNNSSAKNKKKGLPVIRIVAGLAVVLVIVVWWMRKDGPDRQRELGGRKVMSRDWRGDKIKVNFSNVKASSTERVPTVMIMCTMKDSLEHIWHFFQLIDTLDYPRSKLQIAILVSDTQDRTYERALELADERQYKRPKKQQYGRIVVLRKDFAMEDPSALAAMGGIIPAPARMPSSSEKLEAVSADRIVGAGKARHAFGGQIHRRKMLGVSRTWLLTSAMTPDIDYALWIDVDVVDYDKRLVQTLLEHSVNENADVVVPNCVWKTYNELGSYDRNNWQETHESTSLKQTLQEEEVLIEGEPKLCELEKFSAPLFAPTSLNFAGYEDYIKTKRLNMADMVPFTPQTPSVIPLDGVGGCTALIIAGLHRKGAIFPAWPVDHQLETEGFAQLAKKFGGRMVGLPKYYVFHGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N1L2</accession>
    <name>A0A2X0N1L2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C007g04601</name>
        <name evidence="6" type="ORF">BQ5605_C007G04601</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG14 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY61783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N1L2"/>
    <dbReference type="STRING" id="796604.A0A2X0N1L2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035493">
        <property type="term" value="P:SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018791">
        <property type="entry name" value="UV_resistance/autophagy_Atg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157:SF5">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10186">
        <property type="entry name" value="ATG14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="137"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="188"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="326"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="515"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="880"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="626"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="150"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="338"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="889"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="925"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="947"/>
            <end position="970"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY61783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1039" mass="113855" checksum="CEA5144EB90366B2" modified="2018-09-12" version="1">MVLKRADSSTSQWAIPPEPTSLDHDEIKQQRRLRHLSAVLVRNLIVEPRRSHNPTSTSPFLGDAPFDVVGPSSSSCSSLHASAPESSSGPTRPAFASDDLDLLVRNRRRRATSNASLRSKTGPSRSLLRDTLVEAAEEGVGVGSSLSPSKPERTSLRRSMTGDRRIRIQEENDELFGVSVFDGDSATAQASTSHLPDEEQLEADDDVDVDEVGRTDCFSPSSPSEFKRRNRSGSRTSIASAGTTGSGSTIRPRTSELDWNVSAHAPARTFSHSASNPRLPDTLASRTASRGRTAFFSDLQLAKEKRRRIELLHRRMVDSTITLSLFRPREQTEDPVDPTSTRRPNTLSSPTPHRPGRSGSTASIPGRSASRGLALPSAVESAPSLNVLPPFFIAQPACKTLNPTFMVEPSDFLVDPETQDLEDWPGLQEEHVLVSLWTKRSEVGTDMDKGKAKEQNVDSAKADWMVLVEWDVSLDGLVSLGRDPTQFPQLQPNTIIFAMADEYFTAPLPLRTRFRPYTSDDNHSSSCSEDDSDGAGNYSDPGAGGVSHSWRSRRRRRREEEEAEEARRMRKVLVERSLRETRMVKVADVEDLLRFKRIEHERCENKRTLHEQKQRLGAIFGDAAGEAALSRESEELQDQIDDLVAVRDDLRLDIAEIESEFEQRKDELRQRRLRLDSARSMHEARAVGLDQQRALLRQSEGACAKIRRAIEARREQLITLLTHMFPIEPVATDGSSLLFSILSIPLPNSTYPPNSSDDHLSSALGYAAQVVSALAAYIGVPLHYPIKCLGSRSAVIDPISMMRGPRAFPLYGKGVDKYRFDYGVFLLNKDIEQLMYSQGLTVIDLRNTLPNLKALVLALSFASSQAEFASLSLHPPARFPNLSASSTDPEQDLTNELEEASLSRPTVAPGEPHATLTNGHEDAVPSSSDGSESASESGDSDPDADSQSVDTMRTATASKPQSTRTSSSKTKPAKPITGQEKQTIRTLEPAPTCIASNGATTTAGSNGKVKTTVKAKEGSLATQALRNSLWTAVGYGSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N699</accession>
    <name>A0A2X0N699_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C021g09342 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C021g09342</name>
        <name evidence="3" type="ORF">BQ5605_C021G09342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000083">
        <property type="protein sequence ID" value="SGZ21197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N699"/>
    <dbReference type="STRING" id="796604.A0A2X0N699"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070916">
        <property type="term" value="C:inositol phosphoceramide synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070917">
        <property type="term" value="F:inositol phosphoceramide synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006673">
        <property type="term" value="P:inositol phosphoceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013862">
        <property type="entry name" value="Kei1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28077">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE REGULATORY SUBUNIT KEI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28077:SF1">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE REGULATORY SUBUNIT KEI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08552">
        <property type="entry name" value="Kei1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ21197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="404" mass="42898" checksum="2E217AFF7A11A8BB" modified="2018-09-12" version="1">MVGNLRFKSPIRFPVGSFIGMDLKLGVSIISLFAVLNKVAGAYGMMAVLTGGTLAQPLSQLTMYLYSIATLVGVLWGLKKIAEENGPKVLFYAHLFALDHCVGTIFTSLFAVVWYIYVPHDGRRVANSDAQKEMMSEGSASSGTFLDDAARKAAAQAVWRGERGFSAAVLMVGWLLKIYFILCLYSYALHLRRNTYATLPKTRPRGISLTFGRNPVHGNRASRAPLGARPQLATRRSLSGSSGHRYTHVRGNSLATDSGTETSMAETLWEEEGSERASTPVLGTGGVTTTTTTMTRPRRTSLIGMQNPVLVNSTMTTTTTEGLSGTNSGVGEEKGGAGVGVAKTMTTRMNRSLSGGMLQRTESYGSGATQASGNGVAGNALEGKADEDLTTLKTGGNGPVAAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N6I2</accession>
    <name>A0A2X0N6I2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C022g09423 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C022g09423</name>
        <name evidence="2" type="ORF">BQ5605_C022G09423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N6I2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ22060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="282" mass="29753" checksum="D00D9E8B44AD1D69" modified="2018-09-12" version="1">MATTPSPSKKAMQPSASPAPTHPGDFRKSFQREASTGFEDVIRQRAVDSRHNVNRGYGLGQGVQPPRSSGGSGRPLMQTQSMPVLSFAQQDSVFHTSNDILNATFGDEHVTEYRTREVQPMWASPPSLASSQGRGLRRHPSAGSVSTSMVWPAPSGGAGAATAAMSAFSTPAATGPGGGDDGGDGFDLDEVFGPSGGDHQFGAAISIDDDSQRTVTQGIKRGFFETEEGMGEAEDEEMALTDVEDDEMPSALPKARPTAGNRRVLGRTQSVPASAFRGEYQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N8N9</accession>
    <name>A0A2X0N8N9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C037g11587 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C037g11587</name>
        <name evidence="1" type="ORF">BQ5605_C037G11587</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000062">
        <property type="protein sequence ID" value="SGY93385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N8N9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY93385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="54" mass="5974" checksum="F121B5373D3B7863" modified="2018-09-12" version="1">MGYLEQARRCFTLDDCSPHPHSSNVSARHCTPSCMLGSNRDPIAECSACLIYVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NBL7</accession>
    <name>A0A2X0NBL7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C044g12156 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C044g12156</name>
        <name evidence="1" type="ORF">BQ5605_C044G12156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000114">
        <property type="protein sequence ID" value="SGZ31356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NBL7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ31356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="374" mass="41287" checksum="E617296A7A76E282" modified="2018-09-12" version="1">MNRKRVALHDIASTAALCLTREARAGVCHVMRCAGGGGPSQPRQVLGARVAPYHGLPWACSSARCWAPRGSTLLFASAPGSNRAQIPQAHVSIRDDLGPQTAVCTHCKARHWECERSKSTRHFGACCSQGKVRLPPPPQPNLEYRQLLQGSDSEAVAFRENARSYNNALSFTSLAALWDQTQVGTLGPPVFRVFGRLYHRLGALIPAVNQCTAFAQTWLINPAEATDTRLEPDGADSHMQRSTLTKLESMLRTKNHFVREFASAKPRAGWDTAKEWILRLCLPPGRDRLLDPLLTPTHPQPSYIEHGNGDAYLRFRHQHGGSWTSRPYSPVVSSLHPSAMPLRYPLLFPAGEDGFHPNIPLCGFHQARPPIARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NEW9</accession>
    <name>A0A2X0NEW9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Argininosuccinate synthase</fullName>
            <ecNumber evidence="3">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C024g09929</name>
        <name evidence="14" type="ORF">BQ5605_C024G09929</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the argininosuccinate synthase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="3"/>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ26508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NEW9"/>
    <dbReference type="STRING" id="796604.A0A2X0NEW9"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000053">
        <property type="term" value="P:argininosuccinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01999">
        <property type="entry name" value="ASS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000019">
        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1260.10:FF:000003">
        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="entry name" value="Argininosuccinate synthetase, chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00005">
        <property type="entry name" value="Arg_succ_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048268">
        <property type="entry name" value="Arginosuc_syn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048267">
        <property type="entry name" value="Arginosuc_syn_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023434">
        <property type="entry name" value="Arginosuc_synth_type_1_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001770">
        <property type="entry name" value="PRK00509.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587:SF2">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20979">
        <property type="entry name" value="Arginosuc_syn_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="Argininosuccinate synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginosuccinate synthase-like N-terminal" evidence="12">
        <location>
            <begin position="9"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Arginosuccinate synthase C-terminal" evidence="13">
        <location>
            <begin position="188"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGZ26508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="443" mass="49033" checksum="26627CC771E19270" modified="2018-09-12" version="1">MVAKGSAGRVLLAYSGGLDTSIILAWLIEQGYDVVAFMADVGQEEDFEAAEKKAYKIGADKFVLADVKREFVEHLVFPSVQANCIYEVFIWAKGVYLLGTSLARPVIARAMMDVVVEEKCGFVAHGCTGKGNDQVRFELAFYALQPTIKVIAPWRDPEFYNRFAGRAALLDYAKEKDIPVFQTAAKPWSTDENLFHISYEAGILEDPDTTPPSDMWKLIKSLQDAPKDPERISITFTKGIPSSLLIHPAGTEAIPSTEGKEITDSVEIFLTLNALARKHGIGRIDIVENRFIGVKSRGCYESPGATILRKAHMDLEGLVLDRNVRALRDSFVTAELSKILYNGYWFSPEREFVQSCLEKSQESVNGRVRISLIQGNVIVEGRKSDTEALYDAKQSSMDELGGFSPTDTTGFIAIESIRLKKWGEARLAHGATVKPESVYATAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NG13</accession>
    <name>A0A2X0NG13_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glutamine--fructose-6-phosphate transaminase (isomerizing)</fullName>
            <ecNumber evidence="4">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C027g10372</name>
        <name evidence="14" type="ORF">BQ5605_C027G10372</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="4"/>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NG13"/>
    <dbReference type="STRING" id="796604.A0A2X0NG13"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00528"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00714">
        <property type="entry name" value="GFAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000001">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000002">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GFAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047084">
        <property type="entry name" value="GFAT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001484">
        <property type="entry name" value="PRK00331.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937">
        <property type="entry name" value="GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="GLUTAMINE--FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="12">
        <location>
            <begin position="26"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="13">
        <location>
            <begin position="433"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="13">
        <location>
            <begin position="605"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGZ28555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="756" mass="84123" checksum="7A60BA65C869F840" modified="2018-09-12" version="1">MYDECKSIPLHGGSHTQHPGSRSYRCGIFGYASYLCEKDRRSVLEILLNGLQRMEYRGYDSAGLEVDGDNPGEPMIFKGVGKVQVLRKHCYESKVDMNKVFLSQTSIAHTRWATHGVPSILNCHPHQSDALKDFTVVHNGIITNYKELRLVLEKRGYVFRTDTDTEVAAVLAKYLYDSQQGKQVSFTSLIKSVIMELVSILEPYLASARVHGLMLRAYCFRLDLQEGAFAFVFKSVHYPDEVVICRRGSPVLIGVKTEKKLKIDFVDVEFAPTESDIPEIPANPNGLLVPAAASGAKGLIRSQSRAFLSDDGMPQPIEFFIASDASAIVEHTKRVLYLEDDDIAHIAEGDCDDQLASPPPAEFHIHRLRRDDGVSAIRAIETLEIELAAIMKGQFDHFMQKEIYEQPESVVNTMRGRVNFDTHTIMLGGLKAYLHVIRRCRRIVFVACGTSYHSCLATRSIFEELTEIPVSVELASDFLDRKTPIFRDDVCIFVSQSGETADTILAMRYCLERGALNVGVVNVVGSTISRESHCGIHVNAGPEIGVASTKAYTSQYIALVMMAIQLSEDRLSMTGRRNSIIDGLHELPGQIKQILLHDKEFQALAQQTLAKERSLLIMGRGYQHATCLEAALKIKELTYMHSEGILAGELKHGPLALIDESMPVILIMTQDSLYAKTRSALEQVTARKGAPIIIANDTDTSLDSKVHRVIRVPRTVDCLQGLLNIIPLQLLSYHMAVSKGFDVDFPRNLAKSVTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NM76</accession>
    <name>A0A2X0NM76_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C010g05941 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C010g05941</name>
        <name evidence="9" type="ORF">BQ5605_C010G05941</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NM76"/>
    <dbReference type="STRING" id="796604.A0A2X0NM76"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="25"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="138"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="217"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="683"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="683"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="703"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="741"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="756"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY13675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="841" mass="92109" checksum="C46A07AA034BFBB1" modified="2018-09-12" version="1">MDVDEGAAFHSSGVCRQPAKRGARACVTCRRLKKTCHPSETDKNGCKRCEASGLVCTFDRPASSIVDDAGLNRLSAIEATVSTQERRMDTLVQSVGQVSSTLSEILTWLKNGNSPSTHPAQTPPALALSHLHAASHSAPTLPNFSHHGLASIPPHAPSLHSDPSPKAMTASPNPSASSRLEALASVAVDPQPNQNIDRFASRLHAPIQALADAADQLNSGEEGGTGKEGQTEGQSEGQGNQSNPGPDGEEGGSHRPKKRSRHSDIGGITSEASAPQHDVVAKGYVSDREARALVLFHHKELHPFCAILDPDHDTFFTLRQHHFLFDVIIYTGLRAQEGNAAASKQLLQVAEHVRETVRGFIFDPSPPVECIQALLIMACWHDEPYILSGFALRLALSARLDTTFAQIDARGWDLKDERARQLTVQLRTWLYCVFLEFKHSRCTDRMIILRQQDVDVLRGNADRLLQMPFSIKNDLRTVANLKLTFIERGIMETGRTLAREQDVFKHLAYIRETREALTRWHADYDTLLAVHEPSPLSWRRRSHMRHLQEAYFFLPANILGQRLLSPNGSPELIDVGHQALISARTMIRTVLHSPAYAASLKYSGYLMRVDLSFAAMLLLKLAKVYPEASISPEEIVKDVNDLIERQSQCAGGVRFTNLLRIAKDQYIASVYAPSPSADVNNPTAFDESPSSNFHNLRFPKPESPQTSGPIQLRTSIYNSGHYPPTLPGVTFARPDTEFSMAPPPLPTSLPSPSPSNFTAQQQALSASMTSFSKPPPGAGALLPGEKDVIWPEWNGTGGAAGEGMTPTPSTNANADWFGGPAGEWMVGVPDPRWPLNWTQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NNW2</accession>
    <name>A0A2X0NNW2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C013g07293 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C013g07293</name>
        <name evidence="1" type="ORF">BQ5605_C013G07293</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NNW2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY15227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="102" mass="10920" checksum="5BF74CB68CB9A929" modified="2018-09-12" version="1">MGNVGQSAHSAASPSFSLLLFTPYPSHLIPSHLIPSHLIPSHLIPSHLIPSPLNPSPLIKGVPTQPSYHVADGERRAQSVDDVDRLAAIYAEQRTTISSLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NTN4</accession>
    <name>A0A2X0NTN4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C010g06195 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C010g06195</name>
        <name evidence="2" type="ORF">BQ5605_C010G06195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NTN4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY14475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="134" mass="14376" checksum="05D6A99E60BAAC92" modified="2018-09-12" version="1">MVEQGGSNTDGTGVVFHAAGLPITAPSAHDRQTSRAAQVSPSDEGGRASRNQPQASAQTASWTPAKRLLPEELYEQAYSVDTRDPNKTEREQHKAWAVQRTYDALRLASPRWSVSEQHPSTSPKADGPALPASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NVS4</accession>
    <name>A0A2X0NVS4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Eukaryotic translation initiation factor 2A</fullName>
            <shortName evidence="8">eIF-2A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C002g01204</name>
        <name evidence="11" type="ORF">BQ5605_C002G01204</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the WD repeat EIF2A family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY31035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NVS4"/>
    <dbReference type="STRING" id="796604.A0A2X0NVS4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017222">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="179"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="476"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="484"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="528"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY31035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="623" mass="67099" checksum="57C3FCA23631F2B4" modified="2018-09-12" version="1">MATAQYSFRALKSTGLVTGPPDYSALSSYQRPEETVKAQRYSSDGRLFAYCTATGVQVLDAETAANVASIPVRGAIDIAFSPKGTQISTWERHVKSADGEPPHHNLRIWDVATATEVASFSQKAMDRWQLQYTEDEAKAVRIVTNEVHVFNAADFASGIAEKLRAEGVTSCTLSTGANPAVALFFAEKKGAPASVKIHSLEALQTQTCIKTFYKADKITMKWNRSGSNLLFLTQTDVDKTGKSYYGETNLYMMSSAGNFDCRVTLDKEGGIHDFTWSPNDREFAVTYGSDTGSSEPRTDMPAKTVIFDQRVNVINDFGLNPRNFLAYNPQGRLLCIAGFGNLAGQVDVWDRKTLKKVCTFEAPNTVHCEWSPDGRYLMCATLSPRLRVDNGVRFYHCTGGLMHIEAIEELYSVSWRPAPVNLFPFGGPIDAAPSASISVANATPSKPAAATGGAYRPPHARGTLTPTVYKREDEGGAAYDGTTAFPSSANGRTSPTFGARRRAVPGAAAPSGEPGTIQDPSRRKKKGNNNNGKNSANGSGAATPSTGAAATPAVPVPQAAAEVLAGELSPIDKKRRALQKKLTAIEGLKEKKAAGEKLELTQHKKLDSEADIRKELAALELEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NW16</accession>
    <name>A0A2X0NW16_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C012g06691 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C012g06691</name>
        <name evidence="2" type="ORF">BQ5605_C012G06691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY15890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NW16"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY15890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="145" mass="14366" checksum="CA2ADA0F031B99C9" modified="2018-09-12" version="1">MDGPPAEDVAGDEIGASDGDDEGLVSVELSKDPPVYPGAMSTALMAESSRGDETSMCADLTSGVLVLTAGAGVAAGAQSPLMSGEVGCRTEVVRGKLRNRKGARTGIGPAAGELARAPRQLRASKSPPQGGGLAGARPSPLAPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NWF1</accession>
    <name>A0A2X0NWF1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA polymerase II-associated protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C015g07925</name>
        <name evidence="8" type="ORF">BQ5605_C015G07925</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the RPAP3 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NWF1"/>
    <dbReference type="STRING" id="796604.A0A2X0NWF1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101031">
        <property type="term" value="C:protein folding chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051966">
        <property type="entry name" value="RPAP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025986">
        <property type="entry name" value="RPAP3-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46423">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46423:SF1">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13877">
        <property type="entry name" value="RPAP3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="5"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-polymerase II-associated protein 3-like C-terminal" evidence="7">
        <location>
            <begin position="357"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="125"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="294"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="347"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="363"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY17897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="477" mass="51215" checksum="FB04D06B36FA47BF" modified="2018-09-12" version="1">MSKAAEASKDKGNLAFRQANYALALAHYTTSIHLDPSSYLYPLNRSLVHLKLNEWRQAEKDATVALELDPVEASKKAYYRRALARKGMAKYKLAIKDLEQAKEAGAQPKDIDQELNNINKLLQDSGAPTTQHELPLPPPPIPNKRPATPSELPKTPSSTSSVEEPTSEPPPPPPPAQPFGSSKSAAPSKDRLKAALAPRPTSSTKKEKESVPTLSFETKTTKPKPSGDLMTAVSTRSLTRPNAGAANGGSDKTTPSSFAAKKQERTSRFASSAPVKPSSKTAPNAVPPPPPAPATTAAPPAATEAVAPTPPLVESLPKPPTSTSTIPLVPHWTPIPPSKPIQLASPQPLPSTPSYKPPPSSSTFEQTLSSPSLTPSDRLTYLRSIPPATLPTLLKGGALTPDLLTLIIQALASSSIAETNIEPNVDDWLLNFVHHLAKVDRFDMNVMFLEEADRELVRGVFDRAERGLRISKERWGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NWS0</accession>
    <name>A0A2X0NWS0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C012g06971 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C012g06971</name>
        <name evidence="4" type="ORF">BQ5605_C012G06971</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclear import and ribosome assembly adapter family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NWS0"/>
    <dbReference type="STRING" id="796604.A0A2X0NWS0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052616">
        <property type="entry name" value="SYO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057990">
        <property type="entry name" value="TPR_SYO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13347">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13347:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25567">
        <property type="entry name" value="TPR_SYO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SYO1-like TPR repeats" evidence="3">
        <location>
            <begin position="591"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00049983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY16741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="853" mass="91586" checksum="CE472798E77CA5BE" modified="2018-09-12" version="1">MPKQRHRKRVRTARLNANPLGHTEAEAPTTINGASAAAPSGSVASTSSSTATATAQPAKVGKKEADASNLIEQLKSEDDNQRIWATSALSNVFLTLPPGTQRLLLSKNLVGLLIERLTDSNDHVAVEALGTLRNLAVATTSSLVSEMHNKKVLVPLVTHHLPILIQLLPERLGRVPRAAPATAPLPSTAEDRKRVEAENDSRDTRHRLYWDWCENVAMLLWCLAETNTKVLNGLNAHASLLVEFALALIDCEALGLGAAFVESQGMEVEGKKGGKKNKKTAGQKRERVPLFVAVAAAQFLNAFLSANPAAHTSIWATNGSRASLLLLLSTSDAPLGKTARTETHAASDPATDAEEWLQLRVLAFGILLQLSSVGGGRKVERTTIRDQLKECQTLLLELVGTDLAAVATASHESLKEEASLADKSTSSAATAKLASYERQLSTLQLSMEVLSEWCASLDAEALGQDAIEDEDEEWGGIAKDGEGDVEMDEEEAEMGEPEDGIIRKVLPMEEDEDLDVQPTLELGASALTLFVDLQAKLAKLAQPSTSLSFAQSASSGVAPAFAPSLLPTSTTADSTATVEAASLLSSNVVPSELAPIADIISTIHVRAIETLNNLYITLARAISAPNVTSFLSSRKDELQQVWESILNLVHRATVPSGLPSTSADAETIEERQREIVMAGTGVAWGLARISHEMENAALIVGQATTPFLLSLFSHPFATATTPAAESIRVRIAGALGWLGRREGVSNEENETIGTFLLSILPLDKSTFSPFNPTPEVLIQSIDSLIDLYADEDSAYDVAVFRSKGFLPRLEVSVSGVRAQMKKIDRKKFPELRTRADGALENLDAFVKYRKNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NZ86</accession>
    <name>A0A2X0NZ86_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C016g08280 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C016g08280</name>
        <name evidence="2" type="ORF">BQ5605_C016G08280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY21834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NZ86"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="606"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY21834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="719" mass="78534" checksum="9317FC5B9DC2F123" modified="2018-09-12" version="1">MVGPGESPIKAWIAQDTIAYSQEYNFQLGATMDKQRKLQLIETSGLDTGIDNVHLWATMTDSDLWIHVAIPLDVVRTFNHDSAEAFTALKEHIFTITSYDYVYASPVGYNLSAKRFEAMSPRLVLRVLEFRHYGLYRGLASRHSDKSVRDYRSQKSGHPELYRSIERIEHSNRESAQVSNQAQLLKQAHSGQASLETLPELYPHPKTRVSLGSRSGVDAAQVRVGGEREPEGIKQQLPLNGYLRAVNWTLPQFTGPSHWSPRDRTKAESPATAAPALSAQTVEPHPVASTSKAPTPMSTVQTASNPAPAVEPGANADPFQAPVTVLEPVRVPPVDSPPKIPKKESSKPLAASSSLSEVISSLKEVEEHFYEDWTPSSHPEHKRRRSASSSASSSTSIARRHPSSAATMADDDRMDVDDLHPSEDEKDESAISSSNALRSKPLSRASTCSPQLEENVKPLTIKIKGKHLELLSREEGYSQKRARLAPDEGPPRKMDAIIAERVPPLQPATERHLGDLSASSFRSSQMPRPGQLPTATFEPLTPLEDEDDSTQLSGILPLEMVTQVEGQPNAGQGQGRRGSFTPTQPESSRPNGRAASSPFTNPPPSLTATAAIIATSGPTSEASTIRATRHTSAHPTPILHDPTPKIFEEDIKPIPTPPTASTTKRAPEPNLAEFFAPAPGVAQVGHMEKDLDWLRLPEGFKAFVPSRPAVVKRWKKEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NZ95</accession>
    <name>A0A2X0NZ95_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C016g08051 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C016g08051</name>
        <name evidence="1" type="ORF">BQ5605_C016G08051</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY20443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NZ95"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY20443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="217" mass="22958" checksum="3F4E952F4A4174C0" modified="2018-09-12" version="1">MLTSSRKLLALIVTAIVAVLSIAARLVQVTEGRASFEPRVTALTSNCDSEFQLGLFSLDIHHLRVSNELHTSRDKGNPGPALGEPLNVFISPYSDPNFLTGAGSKDGCLSIQFQGADMLSTTGVTKVTDFGDGHRPRKRSVDTAARAEYKPDDGARNGLVGNATATKRTVAPGASRHFSASARSMQYLEPDFGRDLDDGAPTVGKGSIVTVKVVGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P128</accession>
    <name>A0A2X0P128_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ESCRT-II complex subunit VPS25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C002g01059</name>
        <name evidence="6" type="ORF">BQ5605_C002G01059</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS25 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY29505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P128"/>
    <dbReference type="STRING" id="796604.A0A2X0P128"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000141">
        <property type="entry name" value="vacuolar protein-sorting-associated protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.570">
        <property type="entry name" value="Winged helix' DNA-binding domain. Chain C. Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008570">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014041">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05871">
        <property type="entry name" value="ESCRT-II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY29505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="253" mass="28210" checksum="0C2FF9B10B4AE453" modified="2018-09-12" version="1">MQTQPTASSTGGSSLATKSSNGVRGSKGESLKLSLQPMTTSTGFVFPSLYSFPPFFTQQPTESTWSHQRSQWTTLILAYARHHRIFRFDISEATCTHELFNNTAIKRTCPASVGGGRCRLPHRRPPLTDPLPSLVTGRVNISMLRAIFNFMTSSGTAEYDTKPLKGQLPTGALVYWKTSDEWALAIYTWVKDKGLTNSIMTFWELTEANEVETAEFYQLHETILRKALEILARQGKCQVFRSVGEDGDGVKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P3T5</accession>
    <name>A0A2X0P3T5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C007g04888 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C007g04888</name>
        <name evidence="9" type="ORF">BQ5605_C007G04888</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in rRNA-processing and ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UTP23/FCF1 family. UTP23 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY64249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P3T5"/>
    <dbReference type="STRING" id="796604.A0A2X0P3T5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09865">
        <property type="entry name" value="PIN_ScUtp23p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057776">
        <property type="entry name" value="UTP23_sensor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24779">
        <property type="entry name" value="UTP23_sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="UTP23 sensor motif region" evidence="8">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="221"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="221"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY64249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="388" mass="41818" checksum="4B965B4445298A23" modified="2018-09-12" version="1">MRQKRVKSYRKVMQMYQSSFKFREPYQLLVDAEFVNAIVAQKLDLQARLMDVLQGTLKPSQSNCASYATVSSTDRPHSVGPPPPVITQCCMQVLYDLGPSGQPSVNLAKEFERRKCNHLKARPAEECLTAMAGKDNPHRYVIATQSLNLRKHLRTVPGLPIVYLNRSVVLLESPSDQTMKKKLAMENTKLHVPSFELATLASQGSIPSTSNSTSLIDSYNSSNLTKASNDASTSTLPEEGVGKMEFVVPKKKKKGPKGPSGPNPLSIKKKKKKPAIGTTNANASDPSSGSGSGKGKKRPRSEDSSDLNQGTQSGFDRKKRRAENEAVVVTSSSRRGAERGVMALSVGTSEAGEGSGERAKRKRKRKRGSGVVAGVGTGAADKVDGGDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P958</accession>
    <name>A0A2X0P958_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="24">BQ5605_C006g04331 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">BQ5605_C006g04331</name>
        <name evidence="24" type="ORF">BQ5605_C006G04331</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY58017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P958"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0229">DNA integration</keyword>
    <keyword evidence="18" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="16" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="15" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="16" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="17" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="23">
        <location>
            <begin position="415"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="157"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="22">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="SGY58017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="906" mass="101218" checksum="B94528C1D07CA51C" modified="2018-09-12" version="1">MVKSKSLSAKNIWEKLKQHHEGNADPFKIRTLLYEISNASYDEDTNLGEFLQGITDKVDQLEDLGQKFKDEAIVAFRLQALPPSYEMLKQAIKLSDKCSVDYAVNRLTDEYSERKLTGKYDKLLKNAGALAVREGTQVKRDPNCICRGCKGTGHYQIDPECPKYDPNAKRGRNKNHSNKKKKQHKHSKGSADSEESASFALVVKSLEESHSLHINVANRVSQNDQSEIWILDTGASQHYVGNASLLTDHQHGSLNVQTASGQVVHCDTYGTVRFKLRSGASLSLSNVYHLPGAPVNLVSTRALYRSGASCGWEDGRDLMTIKIKGLTVAKTLNGTGYTLDFTRIVEDQAHVATRATVGAPLMEWHRRYGHIAVSLLKELVKSGAVDGLVLTNEKVHDCEPCISSKSRVSKFSESVTHVTDVLQRVFMDIGFVAEDQVDFQGRKAYLAIVDQYSTAKWTFPLKTKSAEEVTRVWITFRQGVEKMTGRKIKRVRTDNGNEFTNKLIGTDFQSQGILHETSAPYTPQQNGTVERFNGSLMVIVRAVLAASKLSWKYWSYAMEYATFVANRVLHSKLDGKTAYEVFYGKKPKVSHFRPFGSTVFAQVPKSKRSKLKPTSVRGTFIGYDNEYNYRMLVDSDSEHKVVITRDIAVLNLQPEEVRAPEVTTLLEGPDEDVGPVLEGNDAGDELQDEVAVEQIAPARPNRPCWEYGDPAVRGQNPGRFEEIDAGNEIHQRTRGQRRIAEQQGLFVTDIPELDPEPPIMSGYAMISTDQPAVPSSYEEAMNNVEADKWKEAIQDELNAMDRHQVLADSDLPHGARALGSKWVFARKENAQGEVIRYKARLVAQGFAQQSGIDYNETFAPVARSTTILFLIAIAASQGLCLEQFNYDSAFLNGTMTEMVYMKYPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PA35</accession>
    <name>A0A2X0PA35_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C007g04803 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C007g04803</name>
        <name evidence="2" type="ORF">BQ5605_C007G04803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY63503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PA35"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015872432" evidence="1">
        <location>
            <begin position="20"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY63503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="188" mass="20273" checksum="50A55E449B027FB9" modified="2018-09-12" version="1">MLYTSLFTLFAAAVLTTSALPKTKCGSASFGNVFQERVCPVCTEKLLRIVGSFQHSDWQGLPQTATSGPDNKKGSTRTVALSSTINLIEEIESYKVNKKADTTTTVFFLHNGPGTVGDNTITYYRETFVTRPLCHGRASQIEWGVDFCYTQGTNASVGALFVGAHTGGLNNVTALLGVQSFDGDCRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PB08</accession>
    <name>A0A2X0PB08_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C004g02735 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C004g02735</name>
        <name evidence="2" type="ORF">BQ5605_C004G02735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY67020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PB08"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY67020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="492" mass="54125" checksum="66E6AA3EE50CD0AF" modified="2018-09-12" version="1">MPVPQTPSSDSDSDEPNLGDSSQSSADDSDSESDSHSHSESEFEDIAIDHRRAIRLWTAIHGSHRNATGRMSQRKWTSLKRWAARRYYSELKMAAKLGISHARLVQAVKKFNRLASKGNAWSRFLSDPVIKSKSQSITKLAAHLWNFLRDQGDLASAQLGEDDEELVRAAFAAAEAGGNTTFTSIVPPTIITRSPSDIPSPTRMEQCKKYIAELRDLAQRMSKLYGVETLAFIVPRYQEDVSPATKATVHSIGGLRFAAHCNDFKDPSGNSLLSNFASKMSWDETLKANEAADLKEGEPFIASYTRMRPSYRYQLCDICFRLIYQQELARWTVLLVAFLANDTALYSALETIHRRSDTGSSTGAFTPQKKMIWSTQGLKALGVKLRIKPGTKSRYEMALHHSAETSPKQTVAQLKAIIDDLRHGRLAIVPSADPNDNTEAEASDNDLNGGEGPLSPRFGGAGDEGGEVRGGEESGEEDREKNSGGVAEETRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PDD9</accession>
    <name>A0A2X0PDD9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C008g04929 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C008g04929</name>
        <name evidence="5" type="ORF">BQ5605_C008G04929</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY78732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PDD9"/>
    <dbReference type="STRING" id="796604.A0A2X0PDD9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024660">
        <property type="entry name" value="UCS_central_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45994">
        <property type="entry name" value="FI21225P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45994:SF1">
        <property type="entry name" value="FI21225P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11701">
        <property type="entry name" value="UNC45-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UNC-45/Cro1/She4 central" evidence="4">
        <location>
            <begin position="47"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY78732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="734" mass="79102" checksum="A5F7C5C6858BA79B" modified="2018-09-12" version="1">MSSSTSSLPSSSSVRPDPVVTDHQTLIDRLKAILSRSSPAKLSSADLQLVFTSLATPASSSSSSSARSLSLAILARAYPSTPTSQPSKEELKTLRETLTSLLSGTDSNDLVAGLSGLSALLQVSPTWTTVSLLSSPESTTLVQHLISTVEHISINTSSKGNSKGKERQSREQSALIELLSIASGQSKLRKLIRDSSNDWLDSLLGSPKKKNGSSEKLIKAMAALTVVKLRLGTEPPEEGGATTTSSAIKEEQEVPKWSLEELCGVFSELFVEETKGEEKISLPLDPTKEAVLLASLEGLAYLTLVPTVALKDQLVSNNGGFLRAFLDLLPKLYPKPMDKTSTPALDYSIATLLSHLVKFPEPLDSTSDQAQLNRLKNFASAQAKSPMQASQTETKEQVTSRMDGIISASPIPTLRHFCLSSSLQTRRLAGRILHALVTPQAKRGLLLQAGVARLLLFLIRRQPKPISIEEGDIEPIQALTKLLITTNPSLVFPDPPLLLEALNIVSTPLKTKPSTATLPLLTIFESLMALTNLISLSAEMANHLASAQQGILKSLHEEDLISSQPMIQRASTELVCNLVNSPNGVEFYSVGTCSTLATQTLLNQRLSILLALCCSEDRATRLAASGALAILCSHSEEVGFVLCLEQGINGLERMGELVREEDEGLRHRGLDVLSSILGAVERCQVAEKRKEGVERLTKGDILRVLIECERAEKVGMLKELAGADRKVLERLLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PDR5</accession>
    <name>A0A2X0PDR5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C020g09140</name>
        <name evidence="10" type="ORF">BQ5605_C020G09140</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="FQNC01000082">
        <property type="protein sequence ID" value="SGZ17739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PDR5"/>
    <dbReference type="STRING" id="796604.A0A2X0PDR5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF66">
        <property type="entry name" value="HISKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="266"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="743"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="433"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="599"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="673"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="875"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="447"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="611"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="673"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="879"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGZ17739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="915" mass="100435" checksum="F834EDB0BA6214CD" modified="2018-09-12" version="1">MGEKLASKEKSEKPRSARKKRISPSTSAFFASQFESSEIEAAYQKDSWTSMKRSVLYGTLFFEINWILSVSMLPKPWSAWNLVASAVLMPLSTIPLVPMALWDWPALHRGARYWIWQFFVFLAVLIASTNSIVDMALCAYFAPDRHCGAKDFITVFFYAAAPPAVSLFALDQVRIGAFGIFVAWTGLVLGTFLRLKGSFIRSAINLFSTYLLFFYVFLLMYSHQREINDRRTFTLRLELKRLYRLKQKAEHRERREADASKRFSNFLFHEVRVPLNISTLAFQNIKESGIVMSNTDCDLSIEFEALESSLAAMAQVLNDVVDHSKLEKGGFSMLSSPFSLHRAMHSIFNQLQLDVDARHLTLETHLDARIDEVCVKSAWPTNECPTRILEGDGFLLGHEMRLRQILTNLTSNAVKFTSAGGKVAVTTKLLRPSFTPGGYQRPEPSPSDYSDLQASSEGHSDTEKGLTSATLEAFAVEGSTSSSSNSSPRAPGEVIVVRFEVRDTGVGIRPRDMQGDRSLFSLFVQTEVGMRQGGTGTGLGLSLVRQLVKLSGGRLGVTSKVDEGSTFWVELSFQVGAAALAAPVDDFITPVKLEARPHSWPVEFSPPTPPSSQMDSAPQFNFTTSSPASPHEKPAYILAASTSNGSDVIEMIAPSEKEKGKIGASEVPQLAISPPAVTPIPTSSTAASSSPAFKDLSGTSPPLSTQAAISNAAAVPMPSPLSLLSITRTPPTPPLEFQDGPIRVLVVDDDALTRKLMTRMIERGGSLVSTANDGEQALEMILARKESDPVGVHVYNYDVIFLDNQMPKQTGLEVVQALRTLGREDLVVGVTANAMQYDQDEYRSRGADEVLTKPVAEASLRKYCAFADVRRKQRREEVAATSSSAASEPRTPPQRPPLTHSLISRDSSRSLPRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PE46</accession>
    <name>A0A2X0PE46_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C008g05038 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C008g05038</name>
        <name evidence="3" type="ORF">BQ5605_C008G05038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PE46"/>
    <dbReference type="STRING" id="796604.A0A2X0PE46"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056138">
        <property type="entry name" value="DUF7721"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39477:SF1">
        <property type="entry name" value="BETA-FLANKING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39477">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24845">
        <property type="entry name" value="DUF7721"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7721" evidence="2">
        <location>
            <begin position="67"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY79095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="228" mass="23149" checksum="86DCFC50F54C7DF4" modified="2018-09-12" version="1">MDNIMNMAQGAYKQYEASQQGHQGQGGGDFGIQGSSALNSADNNRPPQENHSGGGGGCKYSFPVCVDFSQIASLASSHSGEDEGMFAQAMHFVKQGQHENNDIDEQAAQQAHAQAYGDHDSSNMSTNGLGAAAALQAMKKFTSGNQGQQQSSGGGGFQAQLISQAMAEASKLFDQNGGTGDGGSKQDAVGSAGKMALQLLLKSQASGAIGGANSGGLGGLMGMASKFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PEJ7</accession>
    <name>A0A2X0PEJ7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C008g05198 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C008g05198</name>
        <name evidence="1" type="ORF">BQ5605_C008G05198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PEJ7"/>
    <dbReference type="STRING" id="796604.A0A2X0PEJ7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02537">
        <property type="entry name" value="GT8_Glycogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY79685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="303" mass="34965" checksum="B73EAD8AF335A82A" modified="2018-09-12" version="1">MSPAPVKRVWATLLTKTNYLQGCVVLDASLKHHGSQYPLVVFATPSLPQPARDVLRARSIEVHDIEYLEPKDKTELNEHDHRFADTWTKLGVFGLTQYERIVLLDSDMLVTANMDELMTMPLEPDQIAAAHACTCNPRRLAHYPAEWTPENCAHTLARHTDPLPADRFTKPTHQLLNSGLVVLTPTPMNFAKILDTLSIDPIIKTFKFPDQDLLAYVFKGKFVPLSYRYNALKTLRDCHQTMWRDDDVKNVHYILDKPWAKRVQKEDPNEKTHRWWWEFYEKEVLAKWGDAPGRELVEAEVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PG34</accession>
    <name>A0A2X0PG34_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C026g10118 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C026g10118</name>
        <name evidence="2" type="ORF">BQ5605_C026G10118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ27543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PG34"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ27543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="63" mass="7300" checksum="F268702A58D85059" modified="2018-09-12" version="1">MLQSRTEVKRNGTCALSISNRPNPSQPLNSSDYRRWLVLSDLFKRERRETRLEAKANGPKVMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PG46</accession>
    <name>A0A2X0PG46_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C009g05789 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C009g05789</name>
        <name evidence="3" type="ORF">BQ5605_C009G05789</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY85937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PG46"/>
    <dbReference type="STRING" id="796604.A0A2X0PG46"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042292">
        <property type="term" value="F:URM1 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00757">
        <property type="entry name" value="ThiF_MoeB_HesA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF102">
        <property type="entry name" value="ADENYLYLTRANSFERASE AND SULFURTRANSFERASE MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="404"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY85937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="540" mass="58166" checksum="528490B5065C6EC3" modified="2018-09-12" version="1">MASSSPYQLRTELALARAKVAELEQALQAPADHAGPMTDKTSKASTGRTQVRIQGLSQQEYRRYGRQMILPAVGLPGQLKLKQAHILVIGAGGLGCPVLLYLAAAGIGQITILDHDDVELSNLHRQVLHDETRIGVNKAESARIGLERLNSDIVINSYALPFTPTLFDPSNCSSTPDCVLKASFTLILDCTDNPATRHFLNAYAVRYKIPLVSGGAVRSEGTVGVFGLKLQDEVTSGENGTAEYGPCYACVFPAPPSPSRDVADGDGLSEEEREDKTLERTALQGTGACSDEGVLGLLCGQVGVQMGCEAMRMLLGIAKPTLHLLSPLSAHPLRTIKLRARQASCPACGAQSTTKWDEFLQTGHWSEWIDPLCELPGAGQGALRKDEKRWSARALSERLAQGENGGTLRLIDVRPGVEWGICKIPGSESKPTLYDTACNLERKAKLMVPTRHIDIPLAQILRDPSIVLKGQDGSGPQELAFVCRRGNDSIIAARAVRRFKNKKTGTLECLGGCGGSFVVGDLKNGLVGWSRDVDEMFPTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PGF2</accession>
    <name>A0A2X0PGF2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C036g11501 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C036g11501</name>
        <name evidence="2" type="ORF">BQ5605_C036G11501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000063">
        <property type="protein sequence ID" value="SGY95550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PGF2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY95550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="296" mass="33231" checksum="76ABD85BE726689F" modified="2018-09-12" version="1">MTPEGCSDDVDSNADSDPAVDDSEASSSDGGEEAMDRLRQVVNLLENCAPNHLQLEYDTMQAKRQAIMSSNRLWSAEEKADYGQWPLILGDRRKADEWTLKDTIPILKLPLYMATEETKLTKSFLTDPLPILRWRNQPEQEHEWKACKYERCLAVVETSHGAPSITFHQHPADHLTLCPVIGARPEAFCPGAGRRLELRLFDPVYRSWSTAARGASNWVLVEARLSDHTSRFHDSLQQSKGSVDNPNIPSPEQNFANCLKNIVPFLAARAEGPIPRVTGGSDRPTIPYAEWERAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PIL6</accession>
    <name>A0A2X0PIL6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C042g12004 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C042g12004</name>
        <name evidence="2" type="ORF">BQ5605_C042G12004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000116">
        <property type="protein sequence ID" value="SGZ31798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PIL6"/>
    <dbReference type="STRING" id="796604.A0A2X0PIL6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006740">
        <property type="entry name" value="DUF604"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10811">
        <property type="entry name" value="FRINGE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04646">
        <property type="entry name" value="DUF604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ31798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="576" mass="64286" checksum="BD5354029CD1E1FE" modified="2018-09-12" version="1">MATPRSPMLPINGTPRNRRTGFDAFTPAPAEQPVSLSNGRALPPSKPMPSAGKFSGPRRSRIRKLALVIILVSGTLMLFSGSSSSNQSSQKDSLFFCPHSTSKRHTPTVILQADGANARTENRTYWVGGSDPAEFLPFTSQPHDLRFLQSTLLGAPQLHHPQLQDHADKPEQGRQLCHVHRVPSSPRAEIPRTWKDSKIMFGMSTTPDRALYSLPVWPHWVPASKERIDLSGHSSAALAVPEILILTHPPNPTEASRITEAVEEAHGLGINVVMRKQEADRFETRYFMLAKEMWAEAQRKKKTHGVETDWFVFCDDDTFFPDWDSVVRMLSEHDPAKPILIGALSEAVHQVKQWGHISYGGAGIFVSRAMLHVFNGPGQIEECLDKFGSAFGGDAMVAHCAALATKKDIQDVLTLDDTLHQLDIRGDGTGFFQSGFLITSLHHWGSWFTIFPPWSESGSGDLRKSISLVGRAAKAVGGDNWGRRYVFEDGKVVVSLGYSISIEARALSESELNRSEHTWWEFETFHPIRPGKHESIEKRTYYLSAVRHLESGVVRLEHKNQENERADVIWDAREGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PIT3</accession>
    <name>A0A2X0PIT3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C028g10498 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C028g10498</name>
        <name evidence="1" type="ORF">BQ5605_C028G10498</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000080">
        <property type="protein sequence ID" value="SGZ12349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PIT3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ12349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="97" mass="11377" checksum="1E036DC9C2BA2B98" modified="2018-09-12" version="1">MLPIVIPPTIPVYHQEVRTLFRLDQSLAVFPRRPGFHRLRYLFNNPYTTNVVLRLAATRTTIPLRLARVVRRVELATTLIYAGRWARSAPELYYVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PJ64</accession>
    <name>A0A2X0PJ64_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C029g10649 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C029g10649</name>
        <name evidence="2" type="ORF">BQ5605_C029G10649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ15187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PJ64"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ15187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="112" mass="11954" checksum="36943D37E3F5D645" modified="2018-09-12" version="1">MVRSTTATGLTPEAAPFAVGRPTPALETDPLRVDDAPWLSDEKDEAESTESELRWLDVVAFEAEAAEAAGESESDRPARIDAIESTAGALKLNFQNDMIAAAAHSNGKVVQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PJC9</accession>
    <name>A0A2X0PJC9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">MICOS complex subunit MIC60</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Mitofilin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C077g12950</name>
        <name evidence="13" type="ORF">BQ5605_C077G12950</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MICOS complex subunit Mic60 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000126">
        <property type="protein sequence ID" value="SGZ34598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PJC9"/>
    <dbReference type="STRING" id="796604.A0A2X0PJC9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019133">
        <property type="entry name" value="MIC60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415:SF7">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415">
        <property type="entry name" value="MITOFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09731">
        <property type="entry name" value="Mitofilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="164"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGZ34598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="669" mass="73092" checksum="8D18EC99E51FFA39" modified="2018-09-12" version="1">MLRTTAMTGRTACLSSAASRLPSTTMRQALIKRVTPPNIPRLDPFPLQPPRDISYNPNTTLNSKTDLHYYSSNVLPIPPTSNPVPPRIVGRHSLTRKVLSPLALLALTFYGVSIPLGYTSLRYRDFLVESVPGGELIGDALDKYELDRHHVSFNDLNDKVDQALSKSTNVSGTPLTTKSTTPTAPAPTPANVPSGRGWQLKKGDKADPIKAREEIKAKAEQVAQSVSEATQKAKERANEVGGKVEQVKVKVGQVVDKASSAVKSIVPKVEEPESTLPVFAQRPRQLDATPIPPKKAPSETPYDVKPIPTPPQPLPLVAPVINSDEKAASEPMLGQLASTIDSLAKFVENSDESKASAATGVLKSAQDDLKTLAARLQAIKNEGESTLSTSLDQEDWKKAFEEERKKLVDAYKTKLQNELETQQALIDQRLKEEVIAQGVELQRRWVDEIKLKVEQERGGRLAKLDQLEGGIRKLEKVTQGNVDSMTMVQKARKLQTAVKAVEHAIESGRPFINELNALKKLAKESADQAPILDVALSTIDESIASSGVTSFPSLASRFTNSVAFQLKKVSLLPEHAGVLSYVQSYLLSYLLFERKGWAEGSDVVSVIARAKFHLLNKDLDQATREVNSLQGWPKALARDWLNAARGHLEVQQALSVVEAETTVQGLKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PJH8</accession>
    <name>A0A2X0PJH8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C020g09095</name>
        <name evidence="8" type="ORF">BQ5605_C020G09095</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="EMBL" id="FQNC01000082">
        <property type="protein sequence ID" value="SGZ17102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PJH8"/>
    <dbReference type="STRING" id="796604.A0A2X0PJH8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF113">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGZ17102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="470" mass="52112" checksum="5EBFC849EDA51BE2" modified="2018-09-12" version="1">MLQWADFARSVGLLRLTGCRGLPEPTRASLGQRESFAKWSNFARLRSLFFVPIPLSDITPFEMLVLSALAALLPVVVALPANQLPFTTPAPVASAFLTTPENPQNDFEVLYSADHPEHRVRARTPKGLCDPDVEQKSGYLDTANGRHFYFWQFDSRNDPKNDPVVMWLNGGPGCSSFTGLLMELGPCGIRAPEHVPCRNPWSWNNNASLIFLDQPVGVGYSYAEKGDKGTWTTEAAAEDVFAFLTIFFENYAEKFGGRPFFIAGESYAGRYIPVFADYIVTQNLKNELNGKPKINLQGVLIGNGFTNPKMQYGAYFPTGCTNSTGYGPYVDAKDCASMAAALPRCQALIQKCYDDPTDAAVCLSANQYCEATQTERYYETGRNPYDMEKFGGYAEEPDVAKWLNRADIRHQLGVDNEVSGGVKRFIGCSDPVGFRFSTTGDQSKATYPHVTHMVENGVRTLIYAGKRDWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PMV8</accession>
    <name>A0A2X0PMV8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C026g10162 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C026g10162</name>
        <name evidence="3" type="ORF">BQ5605_C026G10162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ27684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PMV8"/>
    <dbReference type="STRING" id="796604.A0A2X0PMV8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ27684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="972" mass="108767" checksum="8AA6E6C7F92CE0F0" modified="2018-09-12" version="1">MNASMSAPWKMQQQLGHRPSLHLTSTAGLPRGYGRSTLSFAPRRVSSMARPRLVPVSMTTRIMYHPATFLLHLGGITLGTMLVPGIATRRQLASNAANDTDTAASSTTAATAAPPRPLVDERIHPSPTPRQLINLANSLRRQFHAPSGSLTPSKLQSPTDPESVVPLPYDACFTLRQLHMTMQRPHITLPPTHIYGYSMPLPTLKPEKWVWRLPATCALHAMLRHLLHRRRNNEKLREMLEPLIVQLVQHALYWDGLIWAAVVKSRGSEAQIEWWWLFEKLRGNITGEGVNEDVGILSTISSGQVIETTTPHSLQRSTEMPLASPSDAATRSRKRRSPAHRRRVERRRVEMSMNPQNMRQSQLDQADLHSVEVLGQFCEPTSAAAADLTSHPLSSIPLPTLELVFDCLARSPSSSTRSSALSIALSMSNLSFRRSARFHSQAFDLALALGRPDHAARFWSDWLVQSPYHSSGSTRRRLANELTRLKPHLRASREEFSSELGQKQLSAMATLTRALHLEWSRRNAASDAERPLVESLLLDLVGSFPASIKQIAVEGQSEYRRIHRLHSAVFSMTRQVMLEVLSSLLGRQVISGASVTDPAELGPPLLPSGSESCPPHRLDIFTFNVLITYALRQLQSYPIASELVSKLRQLGLTPTATTHNLLFETLLHSDLDPLEAIKSGQIPHNDHTWSLLLSHLARTKQAHRIDEVVFYLLPELDHSSVVGNIKPETEPTPPREGRGAEFYTVLLSALVKLRKTGLAERVFRHARWAAQRSRQTRPVVETQVEAEPIARSVRRRGKTTIESTPATSPSPVRVKPWVLPPAAYISMLLLYSNEAQHPHHSLEAGHTPHPRTFVKGWGRRPLRIHTQKARQHELETKFGSSFASSRPRQTRSIDVSGYSRKEAAAIVAMYDLEVSSSVEEMESLVKAMKSDLGRRCLKILFPEMQDSGQGVREAIRRRRRDLTKEVEVVGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PPK6</accession>
    <name>A0A2X0PPK6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C046g12269 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C046g12269</name>
        <name evidence="3" type="ORF">BQ5605_C046G12269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000112">
        <property type="protein sequence ID" value="SGZ30912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PPK6"/>
    <dbReference type="STRING" id="796604.A0A2X0PPK6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006740">
        <property type="entry name" value="DUF604"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10811">
        <property type="entry name" value="FRINGE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04646">
        <property type="entry name" value="DUF604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="988"/>
            <end position="1014"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ30912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1197" mass="135212" checksum="F31D99ADD21FE2F2" modified="2018-09-12" version="1">MSWRTSGYLPIKSPHIGSSSSFPSTSRNGNTASAYSNTSSSWLALARSKIVLLLAVIGFSLLALVSMRSTTVLAEVREPRRPVNSFEGLSEGLLQLLEPITLRQFVLEPTTIKWRAPSSQEEPVSWSKAELLPTRAANLAAYNRDLADNPNMSPTLINGEPVPRHRIRVFPRTVQLDDEVSYPEEADLLFGMTTTVERAKMMSELWTRWLLAPIAPSTDSTRATSSLRPACMILLSSQEDPDDIEDLKRVLKSRGLSCGVRISTYERYEVRVLDMVPQFTAYAVELGRPFKWFIFNDDDTFWLDMRTLRRMLAKYDPSTPLLVGATSESVHQLQHFGRMAFGGAGMLASACLLHKMNNTWDECHKQFRQIFGGDEMLTRCAALAKGATKQTVTTEEKGLRQFDVPGDTTGMLQSGIPFLNLHHYLGGSWVHLFGYGSYLEDFAQIRLVNQVAAFLGGDNMFKRYVFGDGRWLLVLGYSITIFEEKLKKDMLREMEHTWYEGYRLSYEDRPSIPERSGDEGKPAKQTFYIDGVKVLSSTSALFTYAQADAWYEHMASEDRVRIEVLWDGSMDDTQESIYLNYQKSCLGSHSRARFGTLSQLTHLAFADDAVVVVESPAALSKLETLSQTWYEATNGKTNTDKTLVLPLGPNWLRDETAQALPTVQEGESFKWCGYAFFRHGDSKLFWTHVLDRIKAKARAARDRTLSPSGRVFYANAHITSTVLHVLSFDIPPQWFIQAAETALTDFVWGGPRRNTVARDFVFQAREDGGLGLISIGDIVHSVALRFWDAVAGSDEAIWAPLARESWRSLVAATRDFSPWGFFSSTARVEKLYRDSARWGAVVAAARVTLPTIKSELLTLPELLSLPPRLPSLYAEGAKHAYDDADAVAKFAQIADLYWRDEGKGWALVGHRRGFWQHSKEPALRHEHVWARVGQKLKAKALLPKTAVRPARIPLKEDPHPRCFNFFGLTRPFTIRKLRRLVNTVRFPGKDGQDRALPGGQPQEPRVKRFPEGTSQSGRQRFWSWLHDRFASAAEQDTHWRLMYDVTPTRKKQHVQGHASSPSCLFCGNDAAVIETVSHYFFGCAYSASYWSGVLRILFDKLGIEDTDVDPSTFTQEQLTMGLPLLRGRGRTTSKWMLVRLACAIGFQRLHLLRWHVHQRFEKDRVVAPPSIPSALRAFNRDYLSRAGFVPGARDWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LQN7</accession>
    <name>A0A2X0LQN7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C010g06180 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C010g06180</name>
        <name evidence="2" type="ORF">BQ5605_C010G06180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LQN7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY14427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="51" mass="5274" checksum="F73B1AF507A1546C" modified="2018-09-12" version="1">MSAPVGDVASGRRRTVASISCTSSSAVRHTPARPEGRLTDASTTTIPPSNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LSD3</accession>
    <name>A0A2X0LSD3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C012g06808 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C012g06808</name>
        <name evidence="2" type="ORF">BQ5605_C012G06808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LSD3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY16222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="111" mass="12784" checksum="FE9EF8E1689B25A3" modified="2018-09-12" version="1">MSHRSSKTAINLASRAHRRQAPEVRRPPRSIVVNRLQRPKAFLKTTRPIKKQVAKLGIPAEQYLQISQVQESLIRIRSEPTLVDHDHWTTQEVQVNVNSSNTKDRLGDIRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LSL7</accession>
    <name>A0A2X0LSL7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C012g07025 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C012g07025</name>
        <name evidence="7" type="ORF">BQ5605_C012G07025</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LSL7"/>
    <dbReference type="STRING" id="796604.A0A2X0LSL7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.200">
        <property type="entry name" value="Plus-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004343">
        <property type="entry name" value="Plus-3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036128">
        <property type="entry name" value="Plus3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115:SF8">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03126">
        <property type="entry name" value="Plus-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00719">
        <property type="entry name" value="Plus3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159042">
        <property type="entry name" value="Plus3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51360">
        <property type="entry name" value="PLUS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Plus3" evidence="6">
        <location>
            <begin position="250"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="124"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="436"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="518"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="151"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="448"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="525"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY16911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="567" mass="63932" checksum="16EAC78D748A0A43" modified="2018-09-12" version="1">MSDLDDELLGLAEGTSSGRRKTAPAKRKRAPVPQAEDSASDMDMSSASDTEPNSSIKAARNIDDRDPRDKYRLEGKYIDHHDRARQVISQSPALRSIEAMNELDREAILGERQDEINIYTERLQLRQMVQRKEKKDLQGGVDESDEDDEYDMRPTRDRKMTGTTREKRDGLAKLRKSREGKAQKREQKHRARDHDYDDEDNEGEQRRTRIRKPTASSDAYTDSESETERRSSELTAAKAGLGRTTRKEDVATESELGSVLVPRSKLAAFCNAPWFGEWIKDAWVRLGVGLGPDRLPQYRLCRVSSVREGTQSYRLEQTTTNTELELCHGNSVRFFQMHVISDSPMVSREFSRLQRQLLTDQIPLPSQKDVNRIRKKLDEHNDYVMTEADVAAVLAKKGARVNAAAGKARLLIQRDFARQAGDDKLLAEVSAQLATFDAPAPSPGPVGSEHESEQDRMKRLNERNRANNREDIKKAEGRAQEERRRQAVALARGDSSVKVDPSARVKTMTRLTYDRDTLGRATGFADQSNPHTPTKTSAKPSSQSAASGQKFEQLAASRIHVDVDLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LSX6</accession>
    <name>A0A2X0LSX6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C012g06998 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C012g06998</name>
        <name evidence="6" type="ORF">BQ5605_C012G06998</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LSX6"/>
    <dbReference type="STRING" id="796604.A0A2X0LSX6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF76">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="142"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY16808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="813" mass="89433" checksum="ACBF4653205CAA9E" modified="2018-09-12" version="1">MASVSPPDGHGPPSSSTSPLEGSTSSSTGAIRTTSGTNIGGDAASSSEASGIPRTGQRAITSCTYCYRRKIRCNKEFPCSNCIARGISDQCHREPVVVRGHVVGGPQERSPLTFEQLNQENVALRKKAAAQERQINALLRAQKQASKGGQAGTPQASALALRPGSREGSYAGFHDSPISGLAPTSGAAPLTSIQPPGALESCELDVLGLRDPKNHNAPFSSDGKSSLRSDIPSHHTVPLLDLVPIETSTFLVENHFRLLEWVHCVVHVPSFLQEHALWLDCLRRGERERVPRYDVLARYFAIIASTLYFLDVEHGAQIGYTAEGMVSLPRIWFNASLEALQRSDFLCHPSLESLQAICILPLIGHAYGESIYFGSLMHCALGLAQNLKFHLLTAEEPRPGLINRELSRRMWKCLIIAECLVPAKNCQPFSLFYPPAQTVDPLNANDEDLSNDVSCVPRPLHEPTIVSHLLGVSRIADLFREFSQVIFSLPTIEAQWDFAISIDNRLLHLLDFCPALKPRATPYPTHVDLNAPFDYLPWARHLWGTFIPLHRIMCLRLFLGKSYHDSQFLPARQICLNSAREFFAERRRPAPKMYRKSWHVSSLTVIAGMVLGTELIHGRPDPASALGLRAEVIEAMQHLADPGNAMTQRGIELLQSMIIEHDRQSSDFIEPAPRTHQVPPSAPTVSHLINNRYPISPPMPSPTQDVRSPQPLVNNHGNGQMTPMPMNPAMAAPHGMPTHWAIPQPAFPPTFPTAAQVPALEALWPSSINEQQDWSWLTGSIEWPTTLFTDVDGQVAEPHASWFGAGQTLPSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LTM2</accession>
    <name>A0A2X0LTM2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">BQ5605_C011g06552 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">BQ5605_C011g06552</name>
        <name evidence="17" type="ORF">BQ5605_C011G06552</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 19">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LTM2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="16">
        <location>
            <begin position="318"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="SGY12594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="645" mass="71094" checksum="E932228C7C45B07F" modified="2018-09-12" version="1">MSSHGASGPRLPPPAKRIGYTGQPLDARKLRNIDKWPAGVSKKGRLGFYPTQCYLCYKDGHLANTCTVLPHLLLKSRVDTLRAHKISVTTEQARALLHNTLSQDDLEKVLATQALAQSVDDDNEMQEASAASWHIRISGKEGKQCLCTKVSTPFLLDSGATRHMTMRLDLLHNYHPLPADHRVRAELVSLNCLIEDGYNVCGTSASEALGLIVFRNTVDAHFRLRNKQFVLEASPLPPSFPHDSALNVALPPSADLPFWHGRLGHSGVNVVLVSGKVGSIGLNTAAVTPDLMQLVKDCVPCHLGKDAAHCSHAPTTHRATAPIGQVYMDLWGPGPVVSLSGHCYLCGATDQFARYRWLRGISAKSDTTCSIKDLIAFANVQYPGSPFCMLVRDCGGEFMNRELDDWLTSRGVVHKLSAPYEHGQMGLQERSWRSIFDKVCTALAQSGLPLFLWEEAAHTAVYALNLTATSALNDSTPDLVLHASGNPVTKHCCPRGSHLRIWGCCALVPLLPEQCGHKLAPRSRHCFFVGYSQTSKVWRFYDPACRKVFESSQATFYEREFEPVGDWSTCNRGPPAHFGEFAMAATSVTKFGADKAHAVKIIDFQWAFTARPNPDAPTYWEAMSSKEQGMWLLAIERHEIALEPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LTQ3</accession>
    <name>A0A2X0LTQ3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C010g06048 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C010g06048</name>
        <name evidence="3" type="ORF">BQ5605_C010G06048</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LTQ3"/>
    <dbReference type="STRING" id="796604.A0A2X0LTQ3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000138">
        <property type="entry name" value="NADPH dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="2">
        <location>
            <begin position="7"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY14066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="377" mass="41930" checksum="D965067F383BE430" modified="2018-09-12" version="1">MTETRALFKALKVGNVELQHRIAMAPLTRFRAQDDHVHSALAIEYYTQRASPGGLIITEATFILPQAGGYRNVPGCYSPEQIKAWAKIVKGVHGKGGIIFQQLWALGRAAQAKVLQEEGGYDVVSASDVPLDPNGNTRSKDKPRPLTKDEIKEYIAGYAQCAKNFIQGAGGDGVELHFANGYLVDQFTQTNSNKRADEYGGSVKNRCRFAREIVKAVVEAVGEGRTALRISPHSPFQDMKMPEKDMIETFSYLTNALKKDHPGLAYLHVTLPRVAGGFSNDNVKEEENIDFIHDIWAPLPIIIAGQYEPEFAIADAEKYPNSIIAFGRMFISNPDLPYKIKYGAELTPYNRKTFYLYGPDKAEGYTTYKASKIWGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LW82</accession>
    <name>A0A2X0LW82_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C012g06993 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C012g06993</name>
        <name evidence="4" type="ORF">BQ5605_C012G06993</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LW82"/>
    <dbReference type="STRING" id="796604.A0A2X0LW82"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF3">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="3">
        <location>
            <begin position="16"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY16795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="88" mass="9896" checksum="A74646A5BC7913B6" modified="2018-09-12" version="1">MHLSLLNHSVQNNPHIYLAVYSSVPVYEMMVRGIGVMRRRADSYLNATQILKVAGVPKGNRTKILEKDIALGVHEKVQGGYGRYQGTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZ16</accession>
    <name>A0A2X0LZ16_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C017g08344 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C017g08344</name>
        <name evidence="10" type="ORF">BQ5605_C017G08344</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 1/6.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 2/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the C-terminal section; belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY19839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0LZ16"/>
    <dbReference type="UniPathway" id="UPA00868">
        <property type="reaction ID" value="UER00835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004753">
        <property type="term" value="F:saccharopine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033512">
        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via saccharopine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1870.10">
        <property type="entry name" value="Domain 3, Saccharopine reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF22">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="9">
        <location>
            <begin position="344"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="8">
        <location>
            <begin position="532"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY19839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1302" mass="142927" checksum="D273F2D336990540" modified="2018-09-12" version="1">MAPSLVIYLVGLLTIPFLCLLLSRFLDRVTRPKVDGEGFYSDRRDTFALNVLAPQHAWFNMGYWVGGWVHTLPQQTFGEACEALCHLVVEEAVKDRKGFQTTRVFEAGIGAGDSTLVWERSFDGLEYTGVTLEEPQYKRACQRTAELKKARVVHGDAVKVIRDCQEGAFDVIVAVDCAYHFRSRDDFLRSSYQALYPHGYLCMTDLLLSSRTLLMRDRFLLRLLCKAASLPFSNLQTPSRYRANLLQQGYKEIELIDISDDVWPGWLNFIDRHDQSVGFGLHGPAWSGLKIYAKFVKWYSGAGKKGKGELGFYLIRARNLKLAMLRATLPRSFHTSRYNLGTLGIRAEDAKRIWERRSALTPTHVQCLIRDGKHKVLVMPSEKRCFTDQDYKDVGAIITDDLLPHCDVIVGIKEIPLPRLLPSKSQTPKKQPTYLLFSHTHKGQSYNMPLLSTMLQSGARYLDWELLTAPKGPSGKLERTTAFGRFAGLAAMCDGLSSLGTKLLASRGVDTSLIRLVRPSSSRGVEELKQQLARAGKEWNGPKTGVVTIAVAGKGRVGNGAREVLDAFGVEWVDLRRLKSAVENPNSDRNKIYAVHLELSDYLKHKDGNNFDREEYRSHPDNYVSRFDTEVAPYTTLFFNGAYWAPGCPRILSTSQLAKIQKGGSPERMLAIVDAACDFDGALEFVKAATTIDDPVIQYDANSDLISREPSQKGATQISAVEIYPAALPRDASEHFSESILPYVEALLKEPKTSQVKNGNEIAESLKRATIVEGGRLTPGHEHLYQALKGAQSVGVERRKVVVLGSGLVAGPAIRTLASRKDLDVVVASNDLAAAEALVAPYDNVKAVALDATRDGVLEELVTSADVVLRYVDSAQHKHSAPLTCRIVDLLRSLLPAPLHVGIAELCITGSTSLVTASYVSPEMAALQSKYVHSNCRDGDQAASAGITILPELGLDPGIDHASGCRLIEEARESGTKITSFVSFCGGLPGPELSNGPLGYKFSWSPRGVLTAALNSATFRLNGKDRTISGADLLRSNFPRVPILPGFSLEGVANRDSVSYLEQYGLPKDLPTILRGTLRYPGFSRLVDGFKRLGLLSLDKLETVPVRWSVLLDAVLAESGHRAIKTRDERIDAMTKALGSDEKLAKDCLATLEELGLAPTDAQTVTAAQTLPTIPNELTAPLDLLSILLGHQLAYKPDERDAVLLHHELCTQDEKTGEVELFSSTLVQYGTSEASAMATTVGVPIAIGALLILDEQLTKKGIVTPSDPQVWKPLLNELDKMGVRMVETRRKGVGRGVLEELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZN2</accession>
    <name>A0A2X0LZN2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C016g08254 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C016g08254</name>
        <name evidence="5" type="ORF">BQ5605_C016G08254</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY21577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LZN2"/>
    <dbReference type="STRING" id="796604.A0A2X0LZN2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052416">
        <property type="entry name" value="GTF3C_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="24"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="130"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY21577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="828" mass="89797" checksum="A2A465C4F1BB34F4" modified="2018-09-12" version="1">MAITARPRRSTARTVSYVNLFAIASTSGSSSSSSGDSDSDEEGEGSSGGHDASDRKPSASTSKGKSSTKKAGKSEAKSKGKGKGKGRAASSDEDSGSVFGSSDAAEEAADDDDKVDELLEASDDDEAGSEPERSDAGSSDRDANAGPAVKMHRKVLKPTAARGSSSGKHTRTRTDHVHSRRAQPPRQKRKTLLDPNWSSIGASYEPPYRALDEGTDSSPWTIRDEGETAETIDDEAQSKFMEAWAMHPFGLHKSLLRDNAWEKGKWTATGMSPKWGGWYDSKPSTSVLSAEECTVYLPTLVYPSRPTKVYLGEELAAEVDHHNEANSAAMPVDEDEGEAGDDHELEEWVKIWVGPLFDKNEQQLVHLKRFETHRLDEYLPNKPGHILNAGGPVSGLAWCPRPDPAPSTEYLAVSCFCSAEATLKMTKVPGPTMIQIWSLDTSDPSDISLVTSSSAEAQMNFEMALCVDQGDAWELKWCPRGGDRTKLMDHDETEESLGLLGGVFEDGSLAVFTVPNPVEARKQHKMMKTLYLAAKPTLRMELPDTKCTCFDWASYETIVAGCNNGWVAVWSVGDALRSGGKIQTARPTHYFNVHFAIIRSIAVIRVPPLSTALDGTLDLDGEPTIIATTGYDGSVFKTDLRDLSSVSLMHHERSTGIALAYCSQSGLLLSDDPEARVRGSVLKPNKSAARVWLSAHTGPIWSIASSPHHPFAASASADGCLIIANTIRPNRDRIVRGNYSQKVYRLDFHRRLGEYRMIDNMLPEARPTADSNGKIMFRGSMSTASWSPEVGIARVAWHPALDRCALLASGTMCGLVRVDWCEGGKGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M018</accession>
    <name>A0A2X0M018_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C003g01845 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C003g01845</name>
        <name evidence="5" type="ORF">BQ5605_C003G01845</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY37622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M018"/>
    <dbReference type="STRING" id="796604.A0A2X0M018"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045719">
        <property type="term" value="P:negative regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF51">
        <property type="entry name" value="PAS DOMAIN-CONTAINING SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="506"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="310"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="9"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="323"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="422"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY37622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="889" mass="95963" checksum="F592C3E4983032CA" modified="2018-09-12" version="1">MQERHHNRSSSNLATSFGFTPSSPLYRRSTSTKSSPQQNRNASTSSSPTRQQLQAFALQEDESCSGSSDDGSLDPDSDLIILSKFKGKRKSQDLIPTTTTTTASNLSTMDGIAIPGVGVPHSRSSSVDAQQGPSLAQYIQQKRRQASGPFHTLAPRTTSLFGMNRGFTVAMSSSAPGGLVGKEAELAAGVDGEPFAGGRTRSRPASRRGTVSNLHLGSLPSSNAAFYPDSDSDSAMVMTPTTEEWRSLGGQLSLLADIRAKDEARLLALDRPSLLLSRGSLASTSTNSTTSSTSSSIDVTTFSLSAPVDRARSPLGIGPLTPPLSSASTQSFAFDSSQPVTPPAETVKSSFGYQTSRSGFSHSGAVSTSHGDRGGLMGLDTSIEDLRTRPVDEDEDDSMLLGRPRTEPLKQSSKFVPGHRAQQQSDSSVSTTTRPNLSRGSLSTPMGTPSIWTPNRNETDLFDVPTNDSTRANQPELAPLDPSHSLGAIDPRSYSAVTGRRSIDSFVIESEAGRGAYGTVQKAREKGPDGEPIGPTVIIKYIIKQRILADCWKKHKILGPIPVEVHVLDHLRRVPYVARKPSRRKADGGFVKPVGKPVRRNSAPISLKEGVMTGHPNICGMLDFFEDGEFYYLVSPGRLLRLVFLQVMPQAGPPPSNDLFDYVDLHPNGLPPSTIHSILSQLCSALDFLHSHNIVHRDIKDENIILSSTGHVHLIDFGSAAYVKDGKKLDTFSGTLDFAAPEVLRGARYGGKEQDLWALGVLGYVLICGECPFWSPEEAMKGLEKGSRADLALQAKIDLFDGRVEDTNGKRIVSPPMKDGEVEETLSIFLPRPLMSDAVDLLKRCLETDPLDRPTANWVCDHRFLLGKEGWSGKRGWELIVGEEEGSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M044</accession>
    <name>A0A2X0M044_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C019g08935 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C019g08935</name>
        <name evidence="9" type="ORF">BQ5605_C019G08935</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY23418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M044"/>
    <dbReference type="STRING" id="796604.A0A2X0M044"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024461">
        <property type="entry name" value="CCDC90-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360:SF12">
        <property type="entry name" value="MOZ PROTEIN REPRESENTS A CHROMATIN-ASSOCIATED ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07798">
        <property type="entry name" value="CCDC90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="379"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="428"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY23418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="442" mass="47122" checksum="15181701593F9208" modified="2018-09-12" version="1">MAGTSRTIRSYASRIASTSTAPSPSSCLAAGHGTPLHPITRRTPRRFVSSSSTATSDGTTPPPTPSSPPSQRKTRPGPPSKSSPVSSTSTPSGEAHGSLHPRDRARFVNPSTPSDLTTSSTMEPSTSAVKEGSDQPLTEEEPVASTSTLSSNASKAVPASDTAGTSPTHSSSTCMVISPNSSSDSSSFPPPPPHQSIPVPRIPFSTHRFVRQLEHNSINKALAIDLMRATKELLLVKEEQAMKDLVGKQELENEAYLFTAALQELKTGSQIKSRNDGIALRSMTAVLQRETDAISQKMKEDMQRLQSDIQLDMNSRKEETSGELKQLDVSIMDLNSKFTILLGEVRTEIEATKWISTRRVMTAIVVVVVCVVAYISAGPSSQTPKIEPPPPPSIEELGLSDRAGEEAEVTPPGGWSFWGSAPATAADKGVKRVGEEGKEGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M0Z2</accession>
    <name>A0A2X0M0Z2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C019g08994 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C019g08994</name>
        <name evidence="9" type="ORF">BQ5605_C019G08994</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transcriptional coactivator PC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY23909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M0Z2"/>
    <dbReference type="STRING" id="796604.A0A2X0M0Z2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.10">
        <property type="entry name" value="Transcriptional Coactivator Pc4, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003173">
        <property type="entry name" value="PC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009044">
        <property type="entry name" value="ssDNA-bd_transcriptional_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045125">
        <property type="entry name" value="Sub1/Tcp4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13215">
        <property type="entry name" value="RNA POLYMERASE II TRANSCRIPTIONAL COACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02229">
        <property type="entry name" value="PC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54447">
        <property type="entry name" value="ssDNA-binding transcriptional regulator domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcriptional coactivator p15 (PC4) C-terminal" evidence="8">
        <location>
            <begin position="114"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="55"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY23909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="219" mass="24647" checksum="8F2CE37CF2412C60" modified="2018-09-12" version="1">MAPPKSDRFIASDDDLDDDLDAGYGTKKSSKKAQGKKKATPTKKTAKRKSKSSDNDDEDEEDDDDDEEDDEDEAEETDEDEDENEKPKRKKQKNTSSSSGGMLKNDSGERYVVLGNNKRVTVRKFNKAKLIDIRETYDKDGKTGLPGKKGISLSPELWEKLKASIADVNRCGYWSTMILGHFEGRRASSWTSIGQGFRLAPLHRGKPLEQIGDDRRRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M1G1</accession>
    <name>A0A2X0M1G1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peroxisomal membrane protein PEX13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Peroxin-13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">BQ5605_C018g08737</name>
        <name evidence="17" type="ORF">BQ5605_C018G08737</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxin-13 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY26457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M1G1"/>
    <dbReference type="STRING" id="796604.A0A2X0M1G1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007223">
        <property type="entry name" value="Peroxin-13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035463">
        <property type="entry name" value="Pex13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19332">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19332:SF1">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04088">
        <property type="entry name" value="Peroxin-13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 13" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="16">
        <location>
            <begin position="364"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="SGY26457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="457" mass="47197" checksum="48C21AE058F2CB31" modified="2018-09-12" version="1">MASRPAPAKPWERAGVAPQAAASALHASSTNTTVTPSSAAGAFSSGAANTGTSSGSAEAPSLPDRPATMATGSTYGPNTYGNPSRYGTAAGYGTNAAPYGSSYSRLGSYGSSYGSSYGMGSYGSYGMGSMGSMGGMGMGGYGLGMGGYGMGGYGMGGYGMGAPGMMGSDGASLTQRMESGTAATFQVIQSIVGAFGGFAQMLESTFMATHSSFFAMIGVAEQFGHIRFPCDHCSNYLGQVLSIFALIRWVRSFVDRLLGRAARPEGLNAEGFRAFEATTGGVNGTATAGPSTPKFSKKPLIVFLLTVVGLPWLMAKVVRMITARQEEEVRLRALNPRALPPLLDQYGRPLPDQPLAPGGPLDPSSLTFVRATFPYNALNGEELSFGENDIIAVLTPEAERATAGWWQGRLRDGTIGFFPSNYVTSLPLKGQNSVDAKTRAIESGDDRPGAPSAATGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M3V7</accession>
    <name>A0A2X0M3V7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C001g00610 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C001g00610</name>
        <name evidence="3" type="ORF">BQ5605_C001G00610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY48073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M3V7"/>
    <dbReference type="STRING" id="796604.A0A2X0M3V7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37487">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37487:SF2">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015855363" evidence="2">
        <location>
            <begin position="18"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY48073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="221" mass="20784" checksum="DC1214C4C49CAA61" modified="2018-09-12" version="1">MRISVFSALSLVSAALAQSLLINTPTSLIECQPYAVTWSGGMAPYYVSVLPGGQLSATALTTLGEQPTTSTTYTWIVNIASGTTVTLKVLDSAGNSAFTAQVTIQAGSSNACLTASTTAGAAPASSSGAAASSAVSSGAASSAAVSSAAASSAAPATSAAAATSATPAATTTREATTAAAATTASAAAAATSSRAASGASLVGFSSTLLGVVGAAFLAIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M3W5</accession>
    <name>A0A2X0M3W5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g01974 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g01974</name>
        <name evidence="2" type="ORF">BQ5605_C003G01974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY38184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M3W5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY38184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="105" mass="11216" checksum="BC6015FED793A4D8" modified="2018-09-12" version="1">MPAADDTDTAGDTNSVGPTTTLAVPPPRPPTQVAAFAASDLLRDANGYQDWVLTLCSRLPSDVLDYLESGVPHPSWPPSYVPLWDHYARASICAAVEPRMVLPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M454</accession>
    <name>A0A2X0M454_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g02064 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g02064</name>
        <name evidence="2" type="ORF">BQ5605_C003G02064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY38723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M454"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY38723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="38" mass="4333" checksum="FFFC362F189DFDB3" modified="2018-09-12" version="1">MRARNSRIPYGKTPPFTTGLHSQKSQQFQAMRNQKGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M5B8</accession>
    <name>A0A2X0M5B8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g02504 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C003g02504</name>
        <name evidence="1" type="ORF">BQ5605_C003G02504</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY41376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M5B8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY41376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="311" mass="34787" checksum="A1158298AA3F7F62" modified="2018-09-12" version="1">MILGPHIRSYSILSGLLSACLKSRSASFSSLQSGNLILVLAIIHGSSPVAAPTDEPIHSWLLFEKALCYLNQDKPTYVIPRDDAPLWEPSDELVLSKLWPHLDPFGLVDFCVERNLKISLDEQVKHLLNLYDSDFDATLFRQLAFRVPKEKVARIRAALLEIDMDVVTTEAEKHINRILAELQSIGDKIHGITAQMLDMRNEIRGYVSAFGMYILFVTVNLADLHSPGGHVHHASPCRLALKSLPELTSDFGERAMWVPGADDHMRTKTRSDADCVMGDVELMHLHPTPALARSRCLQCSLTFGTFTRLIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M5T0</accession>
    <name>A0A2X0M5T0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g02473 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g02473</name>
        <name evidence="2" type="ORF">BQ5605_C003G02473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY41127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M5T0"/>
    <dbReference type="STRING" id="796604.A0A2X0M5T0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY41127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="417" mass="42731" checksum="94499C3FD58EE158" modified="2018-09-12" version="1">MDSNVVPPVSGTANSIISSWRTKASDKEAIAAGVAQAKDAMKRWGANWSARRKIDEDVSSPPQDDGQSLLSSTSDPTLGKAADGSYRDYRASKSTAASGGEYFHPVSTAGSAPVAIVGDGSISIENGDGGRAKKNSLASSPSKTHFTPAASSPTTKISAVATLAAGSPTEPIPRPLPTTTHKSPTSPPNAPARVYRPATMMAIPGIRDDAKRKAIAADHMAAPAPAPETAAVVPPPSTSPNTASVNGASETSSDAAPFGPPSSFSDRSEKPSTTEVFEPPTASSIAARQTTPPPPLAADAATPEMETTPIAKPKPPIPARPHMTEATSNEEESALNPWTDDGPTQESGGLLPAALIEATSTPSITASRPAWIRNDKPPASHAQINTSSEAVAEDETADEAGWGLEEPEDGESGRAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M785</accession>
    <name>A0A2X0M785_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C001g00619 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C001g00619</name>
        <name evidence="8" type="ORF">BQ5605_C001G00619</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY48147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M785"/>
    <dbReference type="STRING" id="796604.A0A2X0M785"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF18">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="7">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="227"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="341"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="413"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="494"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="259"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="343"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="432"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="509"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="551"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY48147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="608" mass="66904" checksum="7B74ADE4E46AF0CE" modified="2018-09-12" version="1">MYEMDMRQQPVQARMAGAGSRADRRPLDPPPIIRLRIRQPKADRRGRERASAATSAAATTPTGALVSANDPWAARPREFNLHRPGKGLNRNGGDDVDVAADGDDEAVTYTSPSMTHTLFCFASLVGADHDKELYQLSGSRSMHVTGSVVSSLFHLKDQSCFVFPDLSVRTEGKFRFKMSLFEIMEDGVRYCTSIFTDPFQVYSSKRFPGMTKSTELSKAFAEQGLRLRIRRPGASERDEDNDAEDEDGEKNGRLHSHRQSYAQYSSQNGQLGQRSGGYRHSLPHSTPSRITPSPINEARRRHSSHNSWPSPDDPSPRYDSHSVPYHSRPINTAVPFIFHRSAPHQSNTPSPSSGSARGHSPFAQHPGAPTSEHAYASHRIALPPHSFPSAHVQAATGYPAHYLSPPYAFGRTGPAPTTAYAPNPNERFGPRPLQQPQPSHLSSQPLHKQPHQQQGYAPALPYDRADRIFVSPPLASVTLPPLRGHRAMMQIRELSGTSSSSPLPPLSGRHTSWSNAPSKTARDSPLNGDLRSPKARKIEGYSAGGGGEPLRPTEAERRDSEHEQMQEDQARTDRPELAPIKSNNHLSRLLGSTAKDAKAVDSDEPLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M8N1</accession>
    <name>A0A2X0M8N1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C001g00917 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C001g00917</name>
        <name evidence="6" type="ORF">BQ5605_C001G00917</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY50708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M8N1"/>
    <dbReference type="STRING" id="796604.A0A2X0M8N1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019163">
        <property type="entry name" value="THO_Thoc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13375">
        <property type="entry name" value="FMS INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13375:SF3">
        <property type="entry name" value="THO COMPLEX SUBUNIT 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09766">
        <property type="entry name" value="FmiP_Thoc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="251"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="184"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY50708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="294" mass="32892" checksum="828E34032AB0BEA7" modified="2018-09-12" version="1">MTYTATLDSYLPPFQDLLAALQQLSSQLVAARLDSSSSSNTTATDEGSTLNIGLTTQEAGPLFAALHAWNRKGLGEIAALRDETMDARIKMEEAYLRLQNLMFEKDHLQREILACQLYESEYQHLPLIPEDEFLALAQSPQQQPEEVVQLLQEWTRKNPSHSDPSTALKAALIDDPHQLMLTRLQNEHNERKRLDRDKKELSAVKAALVKENERKKARLDQLEQRLELFVKSAKTIQTTMHGDESMAVVSSYKLGQDETSASTGTRDDGEPTSKGAEQDDPTTVAEEGMVVDEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M9A4</accession>
    <name>A0A2X0M9A4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g03833 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g03833</name>
        <name evidence="1" type="ORF">BQ5605_C006G03833</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY54051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M9A4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY54051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="77" mass="8898" checksum="E3A4337BB45CCD26" modified="2018-09-12" version="1">MSRYSFPQRQADSIQAVLVMEVNTQLRRRVVEGYEANPFCQQVKRNLDLSPGFSCVEGVLYFEGRMVVPAVPQLREY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MA20</accession>
    <name>A0A2X0MA20_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C005g03172 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C005g03172</name>
        <name evidence="9" type="ORF">BQ5605_C005G03172</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Transcriptional coregulator that functions together with transcription factor HSF1. Positively regulates the expression of laccase LAC1 during glucose starvation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY72444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MA20"/>
    <dbReference type="STRING" id="796604.A0A2X0MA20"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10233">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000016">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="609"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="508"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="612"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00058890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY72444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="643" mass="69900" checksum="AA4A5000CE62C672" modified="2018-09-12" version="1">MSAGKAIGIDLGTTYSCVGVWQNDRVEIIANDQGNRTTPSYVAFTDSERLIGDAAKNQVAMNPHNTVFDAKRLIGRKWGDSEVQSDMKHWPFKVISKDTKPVIEVEYRGETKQFTPEEISSMILLKMKETAEAYLGTTVSNAVVTVPAYFNDSQRQATKDAGVISGLNVLRIINEPTAAAIAYGLDKKTVGEKNVLIFDLGGGTFDVSLLTIEEGIFEVKATAGDTHLGGEDFDNRLVTHFVAEFKRKNKKDLSSNARALRRLRTACERAKRTLSSAAQTTIEIDSLFEGIDFYTSITRARFEELCQDLFRGTMEPVEKVLRDSKIDKASVHEIVLVGGSTRIPKVQKLVSDYFNGKEPNKSINPDEAVAYGAAVQAAILTGDTSEKTQDLLLLDVAPLSTGIETAGGVMTKLIPRNTTVPTKKSETFSTYADNQPGVLIQVYEGERARTKDNNLLGKFELSGIPPAPRGVPQVEVTFDIDANGILNVSAADKTTGKSNKITISNDKGRLSKDEIERMVREAEQYKQEDEQAAARIQAKNGLETYAYNLRNSIESELKDKLEAAEKESLDKAITETILWLDASSEASQEEYTEKQKELEAVANPIMTKAYGAAGGAPGGAPGAAPSGGFPGAGADEPSVEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MAE6</accession>
    <name>A0A2X0MAE6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C005g03302 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C005g03302</name>
        <name evidence="2" type="ORF">BQ5605_C005G03302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY73550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MAE6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY73550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="398" mass="43822" checksum="00D92F54E1841B24" modified="2018-09-12" version="1">MITHHQIQIGTMSRRHQPAQAAISATASTSKAPDDHDPMPARPPLFGYAYGAKPAQGTTTSAASATVAGASGAQLTTSTIKKKVSLAPPGGSTFKTPVISKPKHGPLRSVHATLSDPRLRVRPNLVNESSRRLPKWGAESLDVDDEEDDQNEMDFSEDEDDDGFETTSDEEKAEDEEMYDVQMGRAQDDSGVGLLETPTNNVYEEEVKRKIRALERGPMIKAYQDNLELATAQYSHVVNDMKTLLKRDLGEEVGQELRFVEAPLFLPQPGLLNRITRYRTQIEGAMEHRSNLDDALIQERDHFVINAAEAIVTQAQDLINQLYEVQRRSIEGHKFYERNSLSSRNQAQAGIDVSSKNFDQESSKLIKKLSTPSKASNAGVPSVALAKIKSKGKGKATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MAH6</accession>
    <name>A0A2X0MAH6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C005g03385 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C005g03385</name>
        <name evidence="9" type="ORF">BQ5605_C005G03385</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY74860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MAH6"/>
    <dbReference type="STRING" id="796604.A0A2X0MAH6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030665">
        <property type="term" value="C:clathrin-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09250">
        <property type="entry name" value="AP-1_Mu1_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14835">
        <property type="entry name" value="AP1_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000006">
        <property type="entry name" value="AP-1 complex subunit mu-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="8">
        <location>
            <begin position="168"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY74860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="437" mass="50034" checksum="C8ED3D647B547FD8" modified="2018-09-12" version="1">MPCSLVAILDLKGKSLIQRSYRDDIPSSTIERFLPLVLEQEEEGAYVTPCFSSSGINYLHIRHNNLYLVALTKRNSNAAEILTFLHKLVAVLTEYFKELEEESIRDNFVIIYELLDEMMDFGYPQTTESKILQEYITQESHKLEVQVRPPMAVTNAVSWRSEGIRYRKNEVFLDVVESVNLLVNTNGNVVRSEILGAVKMKCYLSGMPELRLGLNDKVMFENTGRTSRGKAIEMEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTQVKPLIWAEALIEHHSGSRIEYVVKVKAQFKRRSTANNVEIYIPVPDDADSPKFRAAIGTVHYVPEKSAFVWKIKQLAGGKDYLMRAHFGLPSVKGEEIDKRAPISVKFEIPYFTVSGIQVRYLKVVEKSGYQALPWVRYITQHGDDYSLRTNQLASKAANPNAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MCJ9</accession>
    <name>A0A2X0MCJ9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C013g07234 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C013g07234</name>
        <name evidence="2" type="ORF">BQ5605_C013G07234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MCJ9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY15076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="108" mass="12660" checksum="8B6B466CA716E125" modified="2018-09-12" version="1">MSSVPEPLLRRVSHNSIVTVALVQCAYVARSFYMPVRHEAHRRMRSRQHRSMLMRFSIGQTPGDRQIELKKLLDRVDRKLREVETRLESKGENGTRADTERGWRDGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MDR6</accession>
    <name>A0A2X0MDR6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C012g06887</name>
        <name evidence="12" type="ORF">BQ5605_C012G06887</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MDR6"/>
    <dbReference type="STRING" id="796604.A0A2X0MDR6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="11">
        <location>
            <begin position="202"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY16492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="406" mass="46936" checksum="48411C6ED4A59C49" modified="2018-09-12" version="1">MERNADRLTRKVGPLFITVAIIIIIICVWTFFEVVHPSKFRGPNVSWPSFLLGTFLLPYLVVMMCFHVSVTLCTRIDTTREIGLESFFQQYYQAITVPPGTPFDPQGANLVDSRPLLAWLECTPLAFLVRSQKLVRTNKYTTRAVREVNLARERAAITRKVDRTGVNTETEEPGPMPYEGHRGAVARVCRKCPLREDGHRPIKPERTHHCSVCKTCILCYDHHCPWINNCVGLNNQRYFVLFLCNVSATCAFMSYHSWGSVWMAIASMYLDWPYWAPTYFVLLLWIMTLVLALALTVMTAFQFWQVMVAETTVESYDHKHYATIMAVRGQNFLNPYHLGWKRNLQVFFNLRPEGRYHWLTVLLPIPIGPNGDGWSWKKRKGWREGAIAMEEELTDEEETSDGEEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0ME19</accession>
    <name>A0A2X0ME19_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C009g05654 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C009g05654</name>
        <name evidence="2" type="ORF">BQ5605_C009G05654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY83774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0ME19"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="435"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY83774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="506" mass="54524" checksum="D5A806D29635E70F" modified="2018-09-12" version="1">MAMLKKKGSTSKSSRSKKALIEDENQAHPGSMTMTTTSIKATVVLTQHNTSSSSSALNSSTGGGAGVTALRDSTGNTPLGRHKSLGSNGKTPTTIQRTATTAQQGGGGGLSSIHLMAMWENFQLEAEAQKRALKKKERSRLDTFKRHIASTITQLDPRLRALPLERAIDEFENDLEKALRAIVLDELNAQQQSLLQSASGADLGGGTTTEKGGRKRKRLVGTSPTRPTHLGSDAGPDLSSSTNLQGSIKKARSTASTSAAATLGLGMPSSSRKLHQAPSQGVRSVSGKRTISAHGSPSTTAPRQTRATARSTRPETTWRLRPSTTSSTSFIHNPNLPQTPHGLALKSGQQQGQARAPRRGESILMRSVNDSPLLGELVADDSEEGEQEEEEDGDEYLDTEWSMVSPPLTLPSTMNGKTAKNKTKDKDPKGKRKASSSSVVPPSQQTFRVDLPANAPMYTQEEARKVREQVEREVRERMVEDLRKKLDATVLEKGERERLLGVLNQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0ME32</accession>
    <name>A0A2X0ME32_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C137g13408 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C137g13408</name>
        <name evidence="2" type="ORF">BQ5605_C137G13408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000053">
        <property type="protein sequence ID" value="SGY88805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0ME32"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY88805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="60" mass="6658" checksum="FBE6C3AB79E82524" modified="2018-09-12" version="1">MLRHTRVVSPGERGGGGMLPFSGGEAVAKDSLEAGLVLRHRAQLVQMIRKRTQNRLFGWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MEL0</accession>
    <name>A0A2X0MEL0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C005g03180 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C005g03180</name>
        <name evidence="9" type="ORF">BQ5605_C005G03180</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY72537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MEL0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018820">
        <property type="entry name" value="BRE4-related_DUF2421"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023244">
        <property type="entry name" value="Brefeldin_A-sensitivity_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052430">
        <property type="entry name" value="IVT-Associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804:SF1">
        <property type="entry name" value="DUF2421 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10334">
        <property type="entry name" value="BRE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02047">
        <property type="entry name" value="BREFELDNASP4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
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        <location>
            <begin position="497"/>
            <end position="519"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="525"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="995"/>
            <end position="1014"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="1042"/>
            <end position="1059"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="1066"/>
            <end position="1083"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1095"/>
            <end position="1118"/>
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    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="8">
        <location>
            <begin position="978"/>
            <end position="1113"/>
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    </feature>
    <feature type="domain" description="DUF2421" evidence="7">
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            <begin position="1187"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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            <begin position="271"/>
            <end position="351"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="786"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1376"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="11"/>
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            <begin position="126"/>
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            <begin position="1390"/>
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            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10334"/>
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    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY72537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1399" mass="153965" checksum="8A43DF9949C3B578" modified="2018-09-12" version="1">MNQGQDTQQVSTGSTRIAASAASTPAQPAPRHDLADDDDDRVLANDGQSRPDLGLGEPSRAATSPSPIPITRSLRRSSRRIPSATYATPPRDPSTAARAQDGPIESSPNGRGRSHSHSPSHEPRASTSISSSFISPSSFESPRHPWHDAKYRDTIERAQNKGDPSSWGVLHAAMVTSGYGAGPASAGTSGGPPLSAARDSASGERDRTSARSQSKSRSKSKSSRQNIVKTASQSNLPWLSSAFCRHDTSLSSAAERDAAVLTEEPYSYAQVRPDHDEHGDEQVLEPTPKNESALRSSPRREPRRHDHPASRDEASDTDCDGLDRPRGRSRRRWRRSRSPVHSSSSSSTTSEHHGTFIKRVYSKLLPLSTLQKNIIKCVLAYFIAELFTFVPILTEWLGSPWDVDGPVRNAHVVATVAVYFYPARTIGSMFEADCFMFLGAMYATFLCCGSMAMSVWLDSLGHEQLAHAVVLIFWLGGGYTILAYAKTSVNKKPSFTTACSMVSLITSVIITKEGAFHIGRFQSQAILQVLLIVACGSGISNAVCFLLWPMSATSKLQGDLNKTLASFSTLLDMLTKTFLLDDDITTRPVDLVRAVDQHQASFTTLKSSLAQAKFETFDARMSATTASYDEVVRIMTRLAQGLTGMRAGCTLQYDLIKARADGILVFGKDAEEASIPKTEEAKGLMEELVVFEKFKERVRPSLETLSSLSRSALSLLRTSFVQTKAGSATRKAIRSDDPETGAHLLSADDLLALKQELDSSLVLFKREHSRAIKILYRSLPAQTIYGPGELQKQQDEETPFTRESLGDPENDGEEGPNESLFRVYHYCFNVEEWAKELSQLIEVFVEIRTTEEIVERKAIDRRRRWGPLAGVAAFLSKVETSTRSRPSRRGRRSEVAESTSSRSRRWYSWLATLPSDPGNGPFPVIVDGALSSHQFPSSQLTRFGAFKQHLWIIGYRLRQPSVKFAIKTGAGAALLASAAFVPQLRPVWIRWRGEWALISYMVIMAPVVGGTNFLAFGRVLGTLAGGVLAVLCYISFPENPIALPLLGALVSVPCFYVIVTRPQFGPSSRFVLLTFNLTCLYAFNLREADTHPASIAFHRTVAVSVGVVYALIVNTYIWPFEARRELRKGLSDFFLNSAYLYERIVRTYSVPPPALTARANHSHLHPISDGTVDERTSLISTDAQEQLEVNEDEFVAMEVHLQLSLIKLQGLLSATSHEPRLKGPFPIAPYQTILSSCQTILDLLTSIQQVTNREAWFTTVRRDFVIPANPERREMVGNVLLYFSLLASASTLKTPMPPFLPPAKEAREQLVKRLRTLPVVKRRLVRGGSEGLLYLGYALTMKDVIAQLDLLGATFQSLFGIIGGATSTASFEALFTDEPVDSESTGRDDSSDEETPNPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MFP2</accession>
    <name>A0A2X0MFP2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">BQ5605_C014g07607 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C014g07607</name>
        <name evidence="14" type="ORF">BQ5605_C014G07607</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Mitochondrial peptide exporter (TC 3.A.1.212) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY19296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MFP2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000218">
        <property type="entry name" value="Multidrug ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000854">
        <property type="entry name" value="Multidrug ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="403"/>
            <end position="425"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="431"/>
            <end position="448"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="519"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1184"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1228"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1298"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1328"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1414"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1448"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="253"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="703"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="1187"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1527"/>
            <end position="1768"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
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            <begin position="1041"/>
            <end position="1098"/>
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            <begin position="62"/>
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    </feature>
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            <begin position="655"/>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004651"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005580"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGY19296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1774" mass="193603" checksum="8C3F5F807F223B28" modified="2018-09-12" version="1">MNRKISYPILQGQPEPSEAPSVEAFPAVTKGLSSPRQQPHQRPRATPPTTPRSDSLPMTHLSPRSYSLEASSPHRSPRLGQDTFDNETRRLGTPARSPGNTGGGRTSELAKGGLAAQPVHYRRLSYDDSVHPIPEETADHTIPISTTRTLEWDHSWLSPTAKSPISRPDKVWQSFDDTSRAKIMPGAYMPTLAPAAELQSRTSLEEEKQPSGSSDDGSDSSETARKKPDAKPSVMLLFALTSRSDRLTIVLPATILSVLAGGVAPYMTEVIGKAFGTYSSYALAVMHQPPLSADQLAAARHTMLSQSRTSAITFAGIGVAIFLLQVSSTWMWTIHGERVVRSLRKEVYEGVNKRSIGWFDLGMGVDTSADSDEEEVEDGDDETGAGSGGLVGRFTRETDDVRMATSATCGLVVQYLTSFFVALGISFYRSYILTFAVLGCFPIIAFVITSTESRAHSLVLQDREYSTKSASRLDRILGAIPTVKAFNAEEREVESFSTLTNIAFNIYNRLHMIWGLRGGIVQFIIMAMFVQGFWFGWWLVSHGKASAQSISTCFWACLVASSYVQSCVPLLVTLEKGKVAMAGELNLARQTEITSGPAANRNSAIVKDPRSPQETSRGGRNKIKHFRGASKDSSAPLHDSKTSSTTLNELRRESSSPPLVSAPMSSSAPVFIPVNGAMSKKHRGQSAPRALRKVQPSIFTGELSLRGVTFHYPSRPHPAPPVLQDVNLYLAARETTFIVGGSGSGKSTVASLLMGLYTPESGRIEVDEQGLEWIDDEWLRSHVACVSQGAAIIFEGTVHENVAMGVVGQVREDGSRRKIEDVTREEVTTACRGALLHDFVRDLPEGYDTWLSGEKGAALSGGQRQRLAIARAWIRNPTVLILDEATSALDATSRLLVSEAVKASRKNRTTIIVTHDLSAIEENDFVYVMADGQVVEQGYRRDLEAVDNGPFNQLAQEQQQVPRLELGEEEIQMNDTDVLEELSAEFLSTQTATRSFYWPQSKHNSRRASSNWGLPGAGLMGGGSGVYNVARASRDLQKARRASMGYKATSSALAVPTEPLPRHPSSGQGSLSSRDHTSSKMELGSTSSSPFRSDESMSRRRDSSLSFVILEQLASAAVARRPVMNRVKHKSYIDGAELNTPPHISEKGAVDDVVVEMASDRAPRKVMSLLRIAREFYPTLPNKIALFLGLFLSIVVGVCTPVFSFLLAKLIANLANPHAGKVVTRTSLLVLLVAAIDGFADFFKFYILERCAMGWITSLRCRGLALVLRQDKSFFDRPENTTGALVHSLVKDAEDARLLVGTVISQILVCATMLLLGVFWAMATGWELTLVGVGFAPIFLFLTRGLQVLHAKHEARNKVLRENVARRFHLNVSNIKALRSMSLESVVLAKFEHSLHETYAGAMRAAPLAGMGNGVTLGLTFVAEAVMVYVGALLIANGRYDFEKMATIFSLIIFSMTYAAQIAIYSTFVKDSYSTNCPSQAYLVVFPVVPAITKSQEAIIDLSRLLELDTNTSESEGSMVFPVQGAISFNKVDFSYPSRADVPILREISFSIKAGECVGIVGSSGSGKSTVTALLQRLYEPSNGSILLDGRPLSRVDVKFLRNHVAVVSQHPVLFDLSIADNISYGCNLSEPRHALQAKIERAAQLAHAHNFIQTLPRGYETKLGENASLISGGQLQRLQLARALMQEREILLLDECTSALDATNQALVMQTIEEVKKGRTTIIVTHKLDVMKRCDRLIVIHEGRVVETGTVDDLRARGGHFAQLASGGEWEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MG53</accession>
    <name>A0A2X0MG53_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C035g11439 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C035g11439</name>
        <name evidence="2" type="ORF">BQ5605_C035G11439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000064">
        <property type="protein sequence ID" value="SGY98040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MG53"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY98040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="256" mass="28365" checksum="4370A828515249F8" modified="2018-09-12" version="1">MAPLTSNHHLTSNLARSPSPAPLDRLLSREDIPPLAYDTEAELLAVLSRLESELKKSIDIIFRDGANGANRGEVEKVVLEEFFRGLAPLVWSNCTIAGLPYAQYQALKSKAKFSKTKAFDEVLHQRVMNYQNSLFDAREQNARERVDVPNNYALGVQDVISRDMERLSQLEAVQPTFSEDRPRPVLFASTAAPQAKGRKSVGANKGSIEERPTAQQAQDDYAKASDEINRLLRHLPSLTTAAEEATRVALDTAALH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MGG3</accession>
    <name>A0A2X0MGG3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C034g11281 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C034g11281</name>
        <name evidence="3" type="ORF">BQ5605_C034G11281</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000065">
        <property type="protein sequence ID" value="SGY99346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MGG3"/>
    <dbReference type="STRING" id="796604.A0A2X0MGG3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20533">
        <property type="entry name" value="CYCLIN_CCNL_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036580">
        <property type="entry name" value="Cyclin_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="2">
        <location>
            <begin position="18"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="2">
        <location>
            <begin position="150"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY99346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="283" mass="31674" checksum="9741F40235FFA14A" modified="2018-09-12" version="1">MACHLASSGTSELANGAILIQQVGLMLKAQVDPLIVMATAQILFQRFWFVTSLKHFGIRDIGLGALFLASKLEESPIRIRDLINCYAYLLEFIAHQGRQPTTTSTPLPSDYVPMDYFASSFYDTKDALVVAEMQLLKRLGFQTQSNLPYGHLVNYLKVLELTSYPELVKQSWGYANDMLQTPSPALYPPSTLAVAAIYLATRKHDPPIALPLVPEPWWVLFDATEEDVVDVCTRLLDLYRQWKLDAFGDADQAGIWKVCAKLPHDKQGVRDLIEVATARNNNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MGL3</accession>
    <name>A0A2X0MGL3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C008g05210</name>
        <name evidence="4" type="ORF">BQ5605_C008G05210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MGL3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="67"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY79728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="323" mass="35517" checksum="CDDC15EF0F834296" modified="2018-09-12" version="1">MSHGKERSGQTVPTALLPLPEGPFPRHDLGSTTLQCPICSALHWEFERSPTPGSATPPELLGITLSLFLVDAPGGTGKTFLEKTVLARIRSEGKYALAVASSGTVALLLPECRTAHSRFKIPIDIFDDSTCNVPKQGQLAELYRMCDLIVWDEAPMQHRKCFQLVDRMLQDVRSSTARFGGVTVVLAGDPKQCLPFIPKSWPAQIVDACIMNADFWGKVEALHLSSNMRLLAAADRMTETERPKAQGFADWLLGVGDDSVNKTEDSIALPRELLLPATTKNRSGLIRHVYLVPALELDNKSIGEKVEYFRDRAILAPKNSQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MGU7</accession>
    <name>A0A2X0MGU7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C009g05583 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C009g05583</name>
        <name evidence="5" type="ORF">BQ5605_C009G05583</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY82630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MGU7"/>
    <dbReference type="STRING" id="796604.A0A2X0MGU7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000079">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1430.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.960.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.960.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.960.10">
        <property type="entry name" value="Ribosomal protein L3, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045077">
        <property type="entry name" value="L3_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044892">
        <property type="entry name" value="Ribosomal_L3_dom_3_arc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_uL3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY82630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="299" mass="34081" checksum="66D3801ECC7ED104" modified="2018-09-12" version="1">MIRHRPADTCIFSLFFLVDMSHRKFEHPRHGSLGFLPRKRAARHRGKAKAFPTDDKSKPVHLTAFLGYKAGMTHIVRELERPGSKMHRKEVVEAVTVIDTPPMVVVGVVGYVETPRGLRSLTTVWAEHLSDELKRRFYKNWYRSKKKAFTKSAKKHAETGPKSSIARELERISKYCSVVRVLAHTQIRKTGLQQKKAHLMEIQVNGGSIADKVEFAKSHFEKTVDIASVFEQNENIDIIGVTHGHGFEGVTHRWGTKKLPRKTHKGLRKVACIGAWHPSKVMYSVARAGQNGYHHRTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHK4</accession>
    <name>A0A2X0MHK4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C009g05773 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C009g05773</name>
        <name evidence="3" type="ORF">BQ5605_C009G05773</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY85736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHK4"/>
    <dbReference type="STRING" id="796604.A0A2X0MHK4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF260">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="125"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="648"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="660"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY85736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="669" mass="74217" checksum="2A241601B03B20D1" modified="2018-09-12" version="1">MANSTLPNCNSASNLTCTLTDHDRSTLPSHLPPCEPPHPHPLPTYWSDKFTSPFQHHNAEVTTPLPSKAEVVIVGSGMTGLWALLGVVEGVLERRRRPSAGARSRTRRNDVQEVGSSSSIRSTPRKVIVLEARDFASGATSRNGGHLTGLPLLHFSNWRKLVGIQDTKRMVRLEASSIELIKGLCRREGWGEEVDLVEGGNVHLFDTVEEMESVRNSLDEARRCGLEVGPEYQWLTAEEVHQLYGASPTHLVGAVRIPGNTLYPLKFLTKLYQHCLDRIKDEGAEEELEVELFTGCCVEKVEEGRGEGDVGVGVGKAGGGRWRVLTTGKGVVQWCVPFLALSRERKSSQNSLTERKTDFLHYSGYVLHCTNAYASYLIPSLAQGPLRIVPTRGQVVSVLPTDQEQGASTSVWPRWSNSFSSPQGGEEYYFQRPYPDSDQHGKQQPRSIILGGSRSAASETGYEYGLSDDSRVNEKVGSRLRAYLREQFPEVFGEVEMGSASMLTSKRTTTAQGGTLRFPHEWTGIMGFTQTNQPIVGPLYARSVVDGEVRLLKGQYISAGYSGHGMPRAPGCGKWIAERVMREMDEEDTVHGMVEVEEGWEIIGADDEEQESGGSGAYEGTWDAILPNLWKLTEQRWRDHFREMDDAMQRSGSEERGMRGSQSRWCSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MI03</accession>
    <name>A0A2X0MI03_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C030g10762 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C030g10762</name>
        <name evidence="1" type="ORF">BQ5605_C030G10762</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000069">
        <property type="protein sequence ID" value="SGZ08023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MI03"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ08023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="148" mass="15975" checksum="ED56F94A1FD2846D" modified="2018-09-12" version="1">MRQACSPHLSPEPSGEWIPHIPKHARLDGPKSFTNWLFLNGVIPATWTTAEQLPARDNTDREIIVGSIDSADVSAALDAIPSDELSAPRIFATLNVRIQRVLTAILEGAKGGYKATTASSWVKVKPLRANSAAQIKARRAPNADSNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MI61</accession>
    <name>A0A2X0MI61_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C011g06407 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C011g06407</name>
        <name evidence="1" type="ORF">BQ5605_C011G06407</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MI61"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY12158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="255" mass="28248" checksum="B74147797CDFD398" modified="2018-09-12" version="1">MLEKFDFASPSQRRAFTPMDNRPSLRIDTTPFANIPMYQSAVGSLQYTSTRCRPNIAIAVRAVAQKNSCPTVDDWAAVKRIFRYLNSTFDWGILYRNSSTTRVMIYSDASFADDPVSRRSVGAYASMLAGGAVSWQSKQQSMIATSTTEAEILSASSATREAIWLRRLAEDNVACIQIAKDPVDHMRTKHFDIAHLFVRERVASGEVEVEYCPTHVNAADLMTKPLGPQRFDQLRVLLGMVSLGSLTGGSVRIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIH3</accession>
    <name>A0A2X0MIH3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="26">BQ5605_C107g13194 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="25">BQ5605_C127g13344 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">BQ5605_C107g13194</name>
        <name evidence="25" type="synonym">BQ5605_C127g13344</name>
        <name evidence="26" type="ORF">BQ5605_C107G13194</name>
        <name evidence="25" type="ORF">BQ5605_C127G13344</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22 28">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000025">
        <property type="protein sequence ID" value="SGY27579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000076">
        <property type="protein sequence ID" value="SGZ11199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="526"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="822"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1338"/>
            <end position="1405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGY27579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="SGZ11199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1405" mass="154671" checksum="9D0959D98570AF08" modified="2018-09-12" version="1">MDDTSPPLATGVHPTFPADQLAALTSLLSGLTAAASGTVTTTTSSSTTRPAFPKHARLDGPKMFANWTRQLRLCLADDIRSYVLDGIVPVDWTPSQRSARDVVARELLANSIDSAEVSAVLDAIPTADLTAPKIYLTLKSWYAPDDATRTLELFSRLWSFRPMPGTVGEFDGWIMEFKAIAQEIIDTKTTINDVLATLLLAIAHPSLESFKASFTDEQRTQRSLPAIDSLADRMRVQLRSTNVPSTQSALLASSSSRPTRPKCLACHSPSHRVAECPVRAKHPPPGPCRSCKQNHWSFDCKKALENGKKADTANSTANSQHHVGCIATGFLARRRQLRTNSFVVDSGATSHMVSDKSLFTTYRHIAPTKIGGIAGGINAIGTGNIAFVAASGHPITLTGVLHTPGLFVNLLSVSRLCDTDDVRVAFTKHGIDIDKNGHNIAEGTRLDEGLYLLDADHSKCQHIALLSRSQSSVPLLTLHRCLGHLAPSSIQKMVAAGLLEGLRAGYSDEEVEKFVCNACLSAKGHRLPFPDSDSHSSKRLGLVHSDVLSLPERSLTGKRYLVTFLDDYSRKLWAYAIGHKSEVFSVFKTWLAEVELETGATLKVLRTDNGGEYCSRAFTDFCKVRGTRRQYSIPRTPQQNGRAERVNRSIVEGILALLADAHLPKTFWEEAAAYFVYCKNLVQHSALDKATPNSVWQGGRTTASALHPFGCAAWLTVAPELRSKLDPKAVRVLFTGYDLASKAFRFYDTTTKKVTLGRNATFVDTEFPGLCGDSAEPDDDTHFASAPFADPQTTVKSWTPLYSADPLDLIGSQPQAALDPMDTQPPDFSTYREPASAEESPDELDLIGRHSRDESPDEIDFLTRHHRAFIATDDDTSDTEAIEPVKSITSDPQTWREAMSGDKREVWAKAAADEFNSMRDNFKVFTIDDRSTVPAGATIVSSKFVWKTKRNALGEITGHKARLVAQGNRQRDGIDFTETFAPVARFSSIRSLLALAATNGLHVHQADIDKAYLHGDLDHDIWMTAPRGFDLPGDKVLRLRRSIYGLKQAGRIWNRHIDASLRDLGYTATGTDHCVYSRLDDRQHPHYIALYVDDLLMISPDLAEIERVISGLEQRYGVKRLGPAEYILGIQIRRLDDGSIALSQERYIMDVLARFHFDTTTRGTTVPMTPGLSLTAIPGQATERIRSWYLQAIGSLLYISLGTRPDIAFAVSYLARFANNPGHRHWIAVKHIFRYLRATYRDELVYARGEARITGVVGYSDANWGACVDTSISTMGYVFYIAGSAVSWSSKRQSRVADSTTDAEYLALSHAGKEGIYLSQLLEELHVQPVAPAHIFTDNEAAAGKQRPLQKTLTTRGGGDQAEGRSTGRRQATEGQPRRGRGCEARSKSSISDFIANEIENEGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIS6</accession>
    <name>A0A2X0MIS6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C028g10522 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C028g10522</name>
        <name evidence="8" type="ORF">BQ5605_C028G10522</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000080">
        <property type="protein sequence ID" value="SGZ12713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIS6"/>
    <dbReference type="STRING" id="796604.A0A2X0MIS6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="7">
        <location>
            <begin position="75"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="720"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="827"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="720"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="834"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="886"/>
            <end position="902"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGZ12713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="902" mass="97918" checksum="6504101244153DB4" modified="2018-09-12" version="1">MTENALASLKTNAQRLGARLGENLAEHSRDLGLIATDLSFRPLCITQDGFASGSGGGSGRYLENGAVITSVGIEETKKMLASKRESDRVDGLKRVIAMMTKKLPVLGFFPLVTSLLSPSTPLQARTLISLYIIHCANSAPELALLSINAYQKDLSDSNPIVRAGAIKTLSSMNLPDIRSLVGVAVSKGARDGAWYVRRATADAVATLWRADPTTANRNQLLPTLIVLLNSARPLTIGSALSAWEEMCPTRWDLLHPCFRKWCRMLVDVEEWGQTVVLRVLLQYGRSFFLDPAREGKLDPDAELLLKASDALLQHINPSVVSATIKVHYYLAPSDRLPKIIRPLLRLLRSSPEVQAIVLEDCAVVASTRPELLAEHVSEFYVRFSEVLSLKQARLRILVALTNQTNVREIMKELSIYVKDGDEMFSADAIKAIGSCAQQVPAVSEECLQTLIELTQSKHEVITAQSVLVLRSLLRSPYLPSSTSRPAVITRLVDLLEADRIKAPTARATIYWLVGQFVPDGLVSTVAPDVVRLGAIGFAVESEIAKLQLLTLSAKCVVASTMTSSTPYLREYSLLFEYLATLARYDLTYEVRDRARFLKGVLGAAGLGRADVGKARVGLGEEDFNKGVMVENFTGTSGDANTESESDKARTMSNEQARKILFEGKTFDVERGGSFVLMWLSTRSLLSRRFLSTRIDVNAGDGPFDLGSFSLALPTKRLGFGSSSPSGVPSYPTKVPPSSIRDPLPSLDPTPPGSRGQSRSPTPLRGFGSDSLKNSAHEGAAVVLTPTNFARSANGVEGATRSGSGSVSGMLGGAGMQARRKGFAVLEDFYKNESGSEEESEDDDDDDDDEDEPETEDDDEEDEKGDEDDEDDGEDVEGSDEEEVAISDEKGESIGSTEREVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJ82</accession>
    <name>A0A2X0MJ82_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C002g00975 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C002g00975</name>
        <name evidence="1" type="ORF">BQ5605_C002G00975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY28871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJ82"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY28871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="54" mass="6833" checksum="A9D24580453919D9" modified="2018-09-12" version="1">MWDAERTYQAGRANRRDRLRVRMIVTVQRRMVWTRRSPSRDCMIQRVHRRIEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJB0</accession>
    <name>A0A2X0MJB0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C037g11640 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C037g11640</name>
        <name evidence="4" type="ORF">BQ5605_C037G11640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000062">
        <property type="protein sequence ID" value="SGY94265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="796604.A0A2X0MJB0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000808">
        <property type="entry name" value="Small GTP-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
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        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
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        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
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    </dbReference>
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        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="20"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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        </location>
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            <begin position="517"/>
            <end position="561"/>
        </location>
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            <begin position="27"/>
            <end position="44"/>
        </location>
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            <begin position="52"/>
            <end position="61"/>
        </location>
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            <end position="163"/>
        </location>
    </feature>
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            <begin position="183"/>
            <end position="201"/>
        </location>
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            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
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            <begin position="424"/>
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            <end position="526"/>
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            <begin position="548"/>
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        </location>
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            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
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        </source>
    </evidence>
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        </source>
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            <dbReference type="EMBL" id="SGY94265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="638" mass="67743" checksum="E4EB1F0F7A154CBC" modified="2018-09-12" version="1">MAILLDAPLQPVSVPVSVSPTWAAANPSGVSSRSSSTSGSGSLTTDDDDDASPVSPRIAPIPASPPPVTSLSLSTATLKAQERFIPAISELGTTAISTVAIDQSPSELVGSATTSNANPQPFFPTIDSNVSVTIASPTTFRFPAIAEIPADPSAASTSATPHSAPEDIDEQGTPTTSKRHRTQPSLSRTPSPPTIVTSPAVQNHARPPRARRQSTKNYGPNSLTVGNPQSPSGGDPANQLEAKVVIRESHTLCSRVCEREVMADVGTTAPPRSVGSQGVGKTSLVHRYTTGVFSYSLTSTIGASFLAKRLVVEGCKVRLQIWDTAGQERFRSMAPLYYRGALAAILVYDITNENSFLDIRLWMDELRRNMARDLIIHVVGSKLDLTGQRQVKLVDAQRQIAQWADELDRGDDDTPLNARERESSPSSPNRSRASTRARQGSIPGPLIPNGSTIATTSPLSPLSTAQPVHDSLGARVRKMSTKLGSLPTVATLAATNAPSGGTIGLGTNSSSTLSVHDSLAPTSENMSRSGSKMSLSLGSLGLAGRSRSRNEDDERRAAEDVEREEAARIDRLVNDCPIEVTEVSAKDDIGVEEMFVHITQRLVERKAQIESARILRSRGSIMLRDDTPNPATAGWCCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-11-27" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJG1</accession>
    <name>A0A2X0MJG1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01045 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01045</name>
        <name evidence="2" type="ORF">BQ5605_C002G01045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY29356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:N-acylphosphatidylethanolamine-specific phospholipase D activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:N-acylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032:SF4">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Lactamase_B_2"/>
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    </dbReference>
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        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="145"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY29356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="458" mass="51275" checksum="19A960553B63CB05" modified="2018-09-12" version="1">MSFRHLYHNLRFKTVLKTATATMMTAVSLPVLVSLPSNPSYSTEPLSEGETYLSTQHHKKGGGFVNPWASFSDLGMGPMVLVNMWRDWKKVKIPPLEELPPFVGDVDWGKGRTDWKDKIKATWLGHACYVVEFPSTVEGAKRGPRVLFDPIFSQRCSPSQYVGPARVTKPPIELSQLPEIDAVIISHNHYDHLDLDTLRHIHSSQAPGSVHFFAPLGNKDWFKSNIGTKEEEVTELDWWGERELVMQIGDNGQKEKLRVVCTPCQHVSTERLFWAWGIRSSDDAGLSQFTGRSPFDRNATLWASWAVVAQKGRVWFGGDTGYKAVPRGAKPEHEAGLPTCPAFKEIGQRFGGFDFAMIPIGAYSPRWFMSRIHANPSDAVHIHQDVQSRQSAPMHFATFVLTDEEMTEPPRLLRQECDKRGIKEAEFRVGGFGETVAAEATSRCPELGADNGAPKSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MK76</accession>
    <name>A0A2X0MK76_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C035g11424 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C035g11424</name>
        <name evidence="2" type="ORF">BQ5605_C035G11424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000064">
        <property type="protein sequence ID" value="SGY97762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="796604.A0A2X0MK76"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:protein kinase binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyclin_PHO80-like"/>
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    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF94">
        <property type="entry name" value="PHO85 CYCLIN-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="809"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
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        <location>
            <begin position="34"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="269"/>
        </location>
    </feature>
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            <end position="329"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="473"/>
            <end position="487"/>
        </location>
    </feature>
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        <location>
            <begin position="542"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="832"/>
        </location>
    </feature>
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        <location>
            <begin position="834"/>
            <end position="848"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="946"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="958"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="993"/>
            <end position="1005"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY97762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1046" mass="109100" checksum="9EA12242D20F20FC" modified="2018-09-12" version="1">MSTPLFAPAPNSTFLPQYATTQLDRHDPDSQPHTLEPTSPSPSPSSASSSSPPSSAFTSSSSSLFGTSGSEGHTGTHSSGSGRQLSKGRDFVPQERRPRDISFDRVSTSSSHSSSSHDRATADPSSRGTPVDGGGESPATYAPPRASSMSVDVPTTSRSSSPSLHAPPPHHHQPPHHDDSAPLALAGLSVQETEPRTSSCLTATAKQLAPIPGAAGSSASWTSSAAPSTSAAPPPKTRRASTLSSGSSSAHLTWNDDAAPSATSSSSSKASRDPTRPARRKAARMGSFETGVSASGGGQGYQSGAHAENDESAIDDDGDAADTEADPVGDDQPMQIEDSDQRDSVSAPTAPPISNVDGDQTITSDVPPAAEPHRHVDIVNYPSADLLRLLASLLDQIAQANDALRQRNASASAVSSQSSSGRNTPGGAHRNRNEDDAETLQAFQAGRFDAAPLNSPATPRYRRDVPEDEDDSSSSAGPSGAATPAEEMPVTPGVDLLREVGAGGGVEGFMPSLGGTHAPIPLSRRRGNSFLKKQYEDPRANIRSSSNAGASSTALSQGSSRTASASSPSVPVKPPSPKLAEPPSTSLLTASSNALSSASATLCFHARNIPAISIEAYLLRILKYCPTTNEVFLSLLVYFDRMARVGLEAQRLGLQPGPAGPGASIGGRGGPAPPESRPFAIDSFNVHRLVIAGVTVASKFFSDVFYTNSRYAKVGGLPLQELNQLELQFLLLNDFRLVIPVDELQRYADQLVLFWVGRNGSAPAAATPTLVPSPAPPLATPSRPQVQQAAPAPSITANRAPAFAEGNAAFVPPGRPTPTHRSYSGMHQQLTSHAVASVNSSNAGVASGMTSESTPRSMPIHHWSQQTHAPQPTRASSYSSSTPNPRPGSIRSQPSSSGTSVASTITPGTPSTERQSSEGGDFDSNDQAGGVESSSSDDEVSRRHREQMYEHHYRHSDEEGDEDDAGNHEDDEGGYQATDAEGEKAVVGDGRGPRKKKKGSKKVRGPWRTFVPGFSNRGLGVDSDDDDKSVVGASDKGEGDDDRMQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKR4</accession>
    <name>A0A2X0MKR4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01455 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01455</name>
        <name evidence="2" type="ORF">BQ5605_C002G01455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY33144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MKR4"/>
    <dbReference type="STRING" id="796604.A0A2X0MKR4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010530">
        <property type="entry name" value="B12D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14256:SF1">
        <property type="entry name" value="GEO09626P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14256">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE MLRQ SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06522">
        <property type="entry name" value="B12D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY33144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="88" mass="9933" checksum="74661A34FEE02E24" modified="2018-09-12" version="1">MVVARGASSFRNTAKIWYEPAAIPIYAVVGIACAGAGWYLTHLMRHPDVVWDKRGNPEPWNSVKPDQNTKLHAVNQKFEGGSWKRDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKR9</accession>
    <name>A0A2X0MKR9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C033g11185 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C033g11185</name>
        <name evidence="1" type="ORF">BQ5605_C033G11185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000066">
        <property type="protein sequence ID" value="SGZ02084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MKR9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ02084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="56" mass="6242" checksum="A9F6E44CA0E19E88" modified="2018-09-12" version="1">MGARLADSMIESNVRIGSRFTYFILTPSLVAKDRLRVKASPQVNPVAHGPFDYMCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLT3</accession>
    <name>A0A2X0MLT3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C024g09858 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C024g09858</name>
        <name evidence="9" type="ORF">BQ5605_C024G09858</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>adenylyl-molybdopterin + molybdate = Mo-molybdopterin + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>molybdopterin + ATP + H(+) = adenylyl-molybdopterin + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:31331"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58698"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MoeA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the MoeA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the MoaB/Mog family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ26198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MLT3"/>
    <dbReference type="STRING" id="796604.A0A2X0MLT3"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061598">
        <property type="term" value="F:molybdopterin adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00886">
        <property type="entry name" value="MogA_MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.980.10:FF:000001">
        <property type="entry name" value="Molybdopterin molybdenumtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="entry name" value="MoeA, C-terminal, domain IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.10">
        <property type="entry name" value="Molybdopterin biosynthesis moea protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.190.11">
        <property type="entry name" value="Molybdopterin biosynthesis moea protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192:SF5">
        <property type="entry name" value="GEPHYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="MOLYBDOPTERIN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="MoeA C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="MoeA N-terminal region -like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01079">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="4 5" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="559"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="MoaB/Mog" evidence="8">
        <location>
            <begin position="8"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="MoaB/Mog" evidence="8">
        <location>
            <begin position="429"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="166"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGZ26198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="680" mass="73233" checksum="A089A8FB11EFDE94" modified="2018-09-12" version="1">MPEPYSVAVLVVSDTAAATPSTDLSGPALRELLHSHPGFNVVQQAILPDDKSRIYDQVKRWCDTEGIELVLTSGGTGFGIRDLTPEALTPLIDKHAPGLVIQMINTSLSITPFASIARPVAGIHLNARVQDGTGTMIITLPGSPKGAKENLQSLLKVLPHALELSTRGGSGKAVHKELGNTDRTKSVVPSLSTEPVVAEERKHRGCGHDHGHHAPKPRTGNQPLSQDPSRSVAKRQRASPYPMVEYGEALSLIFDHTPVTSIETMPTDEHLIGHVLAQDVVSDVNIPMRPSTNVDGYAVRCEPLRRRVKHQTTDKPGVYRVEIEYPSSPLPEGSIYRINTGAPLPPGMDSVIMVEDTQVTSTENDEEREVELLAQVDPGENVRNLGSDVKVGEKVLEQGNYISGVGGELGTLAFIVKRSAKVHRKPIVAVLSTGNELVNIQDTSKPKHSTSSLSAIIDSNRPSLIQILRSLHFQVLDLGIIGDTMAETVAALKKGKEKADVTVTTGGTSMGVGDLLKPCIERELGGTVHFGRVAIKPGKPTTFATLPAHPMAPNQDPKLVFALPGNPASALVTFFIFVLPALRKMQGRRKSEWELPRVPVVLNSTVPLDPRPEYHRVWVRPTTQGLKAFSTGGQRSSRTVSLAGVNGLLELPSETKDEKEKKQGETVMCVLVGEIGSSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNP6</accession>
    <name>A0A2X0MNP6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C054g12616 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">BQ5605_C061g12742 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C054g12616</name>
        <name evidence="2" type="synonym">BQ5605_C061g12742</name>
        <name evidence="1" type="ORF">BQ5605_C054G12616</name>
        <name evidence="2" type="ORF">BQ5605_C061G12742</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000093">
        <property type="protein sequence ID" value="SGZ29330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000137">
        <property type="protein sequence ID" value="SGZ35476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MNP6"/>
    <dbReference type="STRING" id="796604.A0A2X0MNP6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ29330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ35476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="354" mass="40542" checksum="982EAC639BBDE040" modified="2018-09-12" version="1">MVRSFALVKIYGMAREGTSLVSGQYPRVKARLVSLYWIAFLSAPTAQQPALEIQPREDIRRCRGDDEYDQRSRPQRKHIVAWYRHAINRLRFTPIAQPVAAVRINGPPRVRPRSEVRTTTPLESILPHPIDPPQRLPRPALPDQSTQYNLLSMDRPYTIRRVRRVLNAKAFTDTIGFRDSLQPDDLKGFWKGVNSKALTAREREVWFKLVRNFTPTRSLQFHQKHDDSPACLVCGAPKDDREHYFFDCVDSGNVWIAARSVLCDALGLDTIDNTHYTAVQLMFGLPKLKASLRDQEGAGRTIEIFTGLVLEMISSGRWGMQKWGTRMEGVGRRRIILEERLKLRAGGAWGRRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MP98</accession>
    <name>A0A2X0MP98_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C017g08351 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C017g08351</name>
        <name evidence="2" type="ORF">BQ5605_C017G08351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY19854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MP98"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY19854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="634" mass="70886" checksum="EA627D8CDE69D83E" modified="2018-09-12" version="1">MGPLGATLLSSPLGPAPINKVSSPRVMTTTNRSWYCDPYKRPPYSFVERTAWPQIALKPLKPHVSIRDDLAPQAAVCTHCKAWHLECERICSQGKVQLPSPPQPNLEYRQLLEGSGSEAKAFRENARSYNNAVPFTSLAAHWDQTQVGTLGPPVFRVLCSNMADRPGRGHRHSTWTRRRRQSHATIYFDKLESILRTGNRFVREFASAKARAGWDTAKEWILRLCLRPGRDRRTHNLPTSSTEMAMLICDSDTKTGDRGRQNLILQVHARSIRLRCLRYSLLFPAGEDGFHPNIPLCGFNQAGPPIARNREQIDNGVQLREVLAGLGLDDGGEEEDKDRDDEDEDGEEAAEEDGDGERQVKGSRWRVSRSQFFAHYLPNATSTSQSRIAPNVPSWTIPGCDGVRCQPWKASAAHHDDVRLRLTGNQGCTGADTACNRPDLIVRVFEAKSGNKRHAGCFGDEYKMNGFCFFAVLRILPRSQIQGASSIVDASRRASSRSDVGHLPHSRPDIEVTTDFRQWNILSERGAVSTKRRSSQMRAINMRLITSFSSTFASLTRVVSKSVQDPPCAFPATAISKGECNIWTIIVFNEAHSHRSLLHTGDSKSRLTRHRSNQFHLGPKGSCIVFLVSVMRSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQ30</accession>
    <name>A0A2X0MQ30_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C044g12137 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C044g12137</name>
        <name evidence="25" type="ORF">BQ5605_C044G12137</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22 27">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000114">
        <property type="protein sequence ID" value="SGZ31307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQ30"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="151"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="465"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="520"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1101"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="465"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGZ31307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1271" mass="138934" checksum="8DCBC139570A250A" modified="2018-09-12" version="1">MSVISPPVCSLAGNYRLTPSAHIKIGGIAGGITAIGMGDVAFVAKTGHPITLRGVLHTPGLHVNLLSVSRLCDTDRVRLAFTSDGIDIAKDGQAIAHGTRVNDGLYLLDADHSRCLLHGFGAGYSDKDVEGFVCNACLGSKGHRLPFPDSESHSPERLGLVHSDVLSFPTSSLTGKRYLVTFLDDHSRKLWAYAIDHKSDVFPTFQTWLAEVELQTDARVRILRTDNGGEYRSNAFTEFCKSRGIRRQYSIPYTPQQNGRAERVNLSIVEGVLALLADSHLPATFWDEAAAYFVYCKNRCSHSALAKQTPELAWDGQRTTATALHPFGCAAWLTVAPDLRSKLDPKATRVIFTGYDLASKAFRFFDHSTNKIVLGRNATFLDDDFPGLPVNTPVDADNTAREFTVPADMCAPASTPAPASTPAPAVKTRTPLVRSAHMDVSSSFDDSAMSAVDVAPGYTGGSLLNSTDTSLSSSPSLPPLSSPTTSSAGEPSIDDSDDPLDLLNSNTAVRLNLMDVHRSDDDTLVTPTPAVAPAGQPSDDDSPDEIDFLSRHHRAFIATDDDDPALEAIEPVKSITSDPQTWREAMSSNEHDLWAQAATDEFTAMRDGFKVFTIEPRSSVPPGATIVTSKFVWKTKRNARGDITGRKARLVAQGNRQRDGIDFSETFAPVARFSSIRCLLALAATNGYHVHQADIDKAYLHGELDHDIWMTTPRGFDFPSDKVLRLRRSIYGLKQAGRIWNRHIDTSLRSLGYRATGTDHCIYSRIDDQQQPHYIALYVDDLLIVSPALDEIERVISGLERRYGVKRLGPAEYILGIQIRRLEDGSIALSQERYIMDVLARFHFDTTTRGATVPMTPGLSLTAVPGQGTERIRSWYLQAIGSLLYISLGTRPDIAFAVSYLSRFANNPGRRHWIAVKHVLRYLRATYRDELLYASGPTKITGVVGYSDANWGACVDTSISTMGFVFYLAGSAVSWSSKRQTRVADSTTDAEYLALSHAGKEAIYLTQLLSELHVRPIDAAHIFTDNEAAAAVAHDPVRTSGTRHIRLREHFVRDMVNRGDISLSHVGTANMVADVFTKALGPKIFGTHCYALGLRTRHPRIRSTSHSRGGGVEPGASRTDLCARNEPGASALDLGARSEPGASARDLGAQSESGASARDLGARSEPGASARDLGARNEPGPLVLSRAESGFLTTRTLELFARLWDFRKMPASVEAYDTWLREYMSIVQEIRDTKTSLNDVLATHVLAMVPLCLVFDQLYYVSNVVIAKSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQI1</accession>
    <name>A0A2X0MQI1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C042g12056 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C042g12056</name>
        <name evidence="1" type="ORF">BQ5605_C042G12056</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000116">
        <property type="protein sequence ID" value="SGZ31967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQI1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ31967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="108" mass="11940" checksum="8A5B85399F51EB15" modified="2018-09-12" version="1">MRTVKPAILDKCVTDFGGQRELTVVGQVLDISSETTVVISARIQAERTVLGSRDSSLFMMIGSERVRYRSASFVKLRVTRVVDLEMLERQGKLPGANLKEAEPGSLWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQT2</accession>
    <name>A0A2X0MQT2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C026g10134 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C026g10134</name>
        <name evidence="2" type="ORF">BQ5605_C026G10134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ27585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQT2"/>
    <dbReference type="STRING" id="796604.A0A2X0MQT2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015957424" evidence="1">
        <location>
            <begin position="20"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ27585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="125" mass="13417" checksum="135B2A9D0EFBB7C6" modified="2018-09-12" version="1">MKYSLVFGALVMAMVDVSALPNDATNTTTPTSKVNEFHPLKNPGATVSHGQPFAQRLAWLFAFDDCIQAKCSCCMTPSANNTCNDNCAVWASYEGLPNQPDMPTSSNCSTCPTCPAARPPNRINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MR81</accession>
    <name>A0A2X0MR81_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C071g12874 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C071g12874</name>
        <name evidence="2" type="ORF">BQ5605_C071G12874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000124">
        <property type="protein sequence ID" value="SGZ34373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MR81"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ34373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="428" mass="46567" checksum="1E5E7FC297E2BD0D" modified="2018-09-12" version="1">MKEIFDLTGTTVPMTPGLSLTAIPGQATERIRSWYLQAIGSLLYISLGTRPDIAFAVSYLARFANNPGHRHWIAVKHIFRYLRATYRDELVYARGEARITGVVGYSDANWGACVDTSISTMGYVFYIAGSAVSWSSKRQSRVADSTTDAEYLALSHAGKEGIYLSQLLEELHVQPVAPAHIFTDNEAAAAVARDPVRVTGTRHIRLREHFVRDMVNRGDISLSHVGTSDMVADIFTKALGPKVFSTHCYALGLRTRHPRLGSASHSRGGGVGDCLIPFVANTGHPITLRGVLHAPGLHVNLLSVSRLCDTNRVRLAFTSDSIDITKDGQAIAHGTRINDGLYLLDADHTKCQQLAFLSRSESTVPLLTLHRCLGHLAPSSIQKMIAAGLLDGFGAGYSDKDVKSPLSARQRRLGRRAHPLARPLAVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MRW1</accession>
    <name>A0A2X0MRW1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C054g12620 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C054g12620</name>
        <name evidence="1" type="ORF">BQ5605_C054G12620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000093">
        <property type="protein sequence ID" value="SGZ29338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MRW1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ29338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="84" mass="9783" checksum="0F9396299CAB1E9D" modified="2018-09-12" version="1">MSTLSRSDDLQVWNLRERVQFAHGDIHPPHSHRFHCCNAFHWDFERLGGRDPPVFRASCNDGKVELPMVKARNFCPVLQELPKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MSB5</accession>
    <name>A0A2X0MSB5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C048g12361 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C048g12361</name>
        <name evidence="2" type="ORF">BQ5605_C048G12361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000110">
        <property type="protein sequence ID" value="SGZ30443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MSB5"/>
    <dbReference type="STRING" id="796604.A0A2X0MSB5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052228">
        <property type="entry name" value="Sec_Metab_Biosynth_Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534">
        <property type="entry name" value="YALI0E05731P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ30443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="314" mass="34028" checksum="271FD1946544A55D" modified="2018-09-12" version="1">MSSTAKQNNVGLDLAGKNVAVAGGTQGIGAATAIQFAQAGADSVYIIGRNKEKADEVVRELKGAGAGAPDTKTYEFIQADLSLVTNVQRVVEELKTKAGDKGIHYLITTQGGPPNGSFSLTTEDHEKRFAIQHISRFGLAYLLAESKTLKEAWITVCAPSGTNSAALVLDDLELKDQGMSWIKRFMKQAKQDGAIQDGLVSAFSKKYPHLRAVHLFPGYVHTQATANQGFPYPITLAQSIFGPLLTYTPLGNTPQSFADIPLYLAANPNAPTNQVGKSYHMNQSMKDVGEPKWCEAEAGKDRERLWEAFKGFYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MT61</accession>
    <name>A0A2X0MT61_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g04118 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g04118</name>
        <name evidence="1" type="ORF">BQ5605_C006G04118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY56252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MT61"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY56252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="75" mass="8252" checksum="3201E5ED7B815BC0" modified="2018-09-12" version="1">MVEGTTLRCGRHAKQVVWEAESHVPGRMDGKWNLGEGSRSGLADAETALANWDALDRELPMTSRHVVCLSFSDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MTB8</accession>
    <name>A0A2X0MTB8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C002g01367 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C002g01367</name>
        <name evidence="1" type="ORF">BQ5605_C002G01367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY32465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MTB8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY32465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="182" mass="20970" checksum="953FA4DF5292CB64" modified="2018-09-12" version="1">MATAQSSIAHVRIPRTLPFVAEAGRSEPTMNPKWLRLNRVDLGRTIEIPSGTSWRCGWSGSEVALHLVGAAASTRWRDRRLSSSWRKGMLSLLDYHRTMRRRRIRSCDSGCVNERSSTSRRELQPRRRGPIRRSAAAMTMHSIRSSLFERGHAQRSRMTRRTQLESRQKVRAIRTSWNGRCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MVK6</accession>
    <name>A0A2X0MVK6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">BQ5605_C003g02199 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">BQ5605_C003g02199</name>
        <name evidence="15" type="ORF">BQ5605_C003G02199</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MVK6"/>
    <dbReference type="STRING" id="796604.A0A2X0MVK6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000010">
        <property type="entry name" value="Acetyl-CoA acetyltransferase (Thiolase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF8">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="13">
        <location>
            <begin position="33"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="14">
        <location>
            <begin position="298"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="11">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SGY39322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="420" mass="43517" checksum="0B86709F96917B40" modified="2018-09-12" version="1">MSSALERVAALASHLVPSSRGKKAVLAKKDDDVVIVSAVRTPLIRAKKGPFKDTTPEDLLAAALKAAVDRAGIDINLVEDIQVGNVLPPGGGATVARMAQLAVGFPVTSSICTLNRQCSSGLQAINNIALQIAAGQIDVGIGAGVESMTMGYGAGVMPEKFSDKILEHEPSADCLVPMGITSENVAAKYNVTRQAQDEFAAKSFQKAVAAQKAGKFDSEIVPVTVQVTDPKTGEETTVTVTKDDGIRDGVTAESLGKLKPVFSKTGSTHAGNASQVSDGAAAVLLTRRSFAKKHNLPVLGKFVCAAVVGVEPKLMGIGPAFAIPKALEKAGLTIEEVDLWEINEAFASQAVMSIEHLKIPYEKVNPVGGAIAFGHPLGATGARQYATALAEAKRSGAKVIVSSMCIGSGMGMASVFVNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MXU0</accession>
    <name>A0A2X0MXU0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="11">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C001g00464</name>
        <name evidence="13" type="ORF">BQ5605_C001G00464</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">In the C-terminal section; belongs to the aldose epimerase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="11"/>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY46711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MXU0"/>
    <dbReference type="STRING" id="796604.A0A2X0MXU0"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725:SF47">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01713">
        <property type="entry name" value="NUCEPIMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="7 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 11" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="12">
        <location>
            <begin position="6"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGY46711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="382" mass="41528" checksum="66EFC12F7C5AD13C" modified="2018-09-12" version="1">MARKNILVTGAAGYIGSHIALCCLLSGEYSVVTIDNFSNSFPTAMTRVSKLAVEALPADASDEEKKACQIDVIKGDITIKSDIEKIFEAYKAKGGIWGVIHVAALKAVGESAEKPIQYYEANITATINLLDVMARHQVYNIVYSSSATVYGAPQQIPIPETSVLAPESVYGRTKHMSELIIRDVCDSNPDTWRAIGLRYFNPAGAHPSGEIGEDPRGKPGNLLPLLAQMAVGKFAKEGLKIFGNDYPTPDGTCVRDYIHVMDLAQGHVDALAALTRDSTYASLGTQKSQFGGSGGKYKAYNLGKGKGMSVLQMVEAMRVASGFEYKYEIVGRRVGDVPDLTADPALAEKEMGFKAPRNLQEMCRDQWNWQSKNPKGYEGQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MYW7</accession>
    <name>A0A2X0MYW7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C001g00824 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C001g00824</name>
        <name evidence="1" type="ORF">BQ5605_C001G00824</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY49830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MYW7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY49830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="113" mass="13230" checksum="6EFEA925C45ED2FC" modified="2018-09-12" version="1">MSISPSSRVLVVPPDAESLRLRVIGRHLGAWLDKRQSLLPTWRMMIRCSLRQLVLSNVKFRLEELQIVCQTHNLQGYSLGDQRLLIFGYSIVFMRWALSSMREWLHLQAKHSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MYY7</accession>
    <name>A0A2X0MYY7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BQ5605_C001g00854 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C001g00854</name>
        <name evidence="11" type="ORF">BQ5605_C001G00854</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY50076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MYY7"/>
    <dbReference type="STRING" id="796604.A0A2X0MYY7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF414">
        <property type="entry name" value="ADR239WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016149158" evidence="7">
        <location>
            <begin position="24"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="106"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="235"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="703"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="404"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="404"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="428"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="455"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="498"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="530"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="540"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="553"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY50076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="884" mass="94845" checksum="2769EB765A8AF384" modified="2018-09-12" version="1">MKFSNSIIACALLASGWADLARTHGVDAGGGSIGVSLPPTTPSDPSCTGSNEWFSPYRSTFEAHERGENLDQLKQPGSIDDSEYLLNSNFSINNCQTTRYYYLDIHETRAAPDGFEREMFLFNGRINGPLIEANQGDTIVVYVHNYLDIGTTVHWHGLAQNGSGWADGPLGVTQCPIPPGTTFIYKYTLSRFDQCGTYWYHAHRLAHYSDGLVAPLVIHCPDDPLKRGDLYDIDQVVVVRDHYHPLSTRIISALLVNGSFQGSSATPSPNAGLINGRGRYNCSFAPEGSVCTDDAPLTEFEFPKGSRVRLRLINPSAHAQFLVSVDEHPLNVVEADDTPVWQTTVHRIPINVGQRYSAILNTADNNEGDSFWMRADINTACFGANFTDLNPEVKAIIRIGSASSSASSSVSSSASSENGSNPPSQGASNGSSDSSGDHSSSGNPSDLQQSSNNNGTGGDGTSNGGGDGSTDNSWNSTGDGSDRFHGGDTGTSGDAPDGSDQSDNSGDGNASGDGRGDWGNQEDSDGSGDSGDQQGSQRGSRWKRAAGLRKRNGNNNDNNDNNDNNDNNDNNDNNDNNDNNDSNDNNDNNDNNDNNNSGSNTNTNQNLPTSTDWSDAVNGSCHDLAESTLVPRVPFNPPGASISHEFRATILTTPSGAFGFAANNVSFESFVNDPFLFRVNRGDDIPLGLSASIVLDDKSLAHDIVINNANPIDHPFHLHGVQMHLIARGAGSVSADNISSVALNLNNPIRRDTISVTGNTFVIVRVVADNAGVWAIHCHILLHQVTGLMGVVVIRPDLIRKMEIPQHARDVSMPDQSNGCPLIRSLTPRCVHPSQLCTLGSSLSSAQGQDPQPNIEPGRRIRRSINPLLPSKDFIRKRVLLNQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MZM2</accession>
    <name>A0A2X0MZM2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">BQ5605_C006g03900 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BQ5605_C006g03900</name>
        <name evidence="16" type="ORF">BQ5605_C006G03900</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 18">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY54708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MZM2"/>
    <dbReference type="STRING" id="796604.A0A2X0MZM2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="15">
        <location>
            <begin position="24"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SGY54708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="370" mass="41206" checksum="5DBDB5B750467B02" modified="2018-09-12" version="1">MTYCEIAKKTQSHVNNQPPLPVPRTTHPRARATAKTISPSGPQTPLISHNTFIDDFSRKAWAFPLLRKSDALAAFQRWKAEVENASGAKIKTLRSDNGGEYTAFNKFCAEQGIRRDKSVPYTPEQNGRAERLNRSIVEGVLALFHDSGLPAHLWEEATQYYLDCKNLTPHAGIDGGVPDAIWHGIPQDLSRLRTFGCRAWATVPQHERTKLEPKGIPLIFVGYDQHAKAYRLYDPDTQRTRISRNVTFVETEFPAAARQVCEPEPRPGASFGTSRSCHTSNFSVAHAEHCFGVTTIVLAYAAHNASPEAPLDMLPSRDADPAHWHQAMRSPHAAEWQTEAIDEFTSLLNQYKVYVILDQAALPDGAKCQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MZT6</accession>
    <name>A0A2X0MZT6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C008g05335 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C008g05335</name>
        <name evidence="1" type="ORF">BQ5605_C008G05335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY80243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MZT6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY80243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="67" mass="7572" checksum="7E0C17688267D446" modified="2018-09-12" version="1">MSDLSQTPANSVTPQSPFADDFQALKEKVIELERQLAELRDTIDPDSFNKRFSDAITDSNKELCRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N0I2</accession>
    <name>A0A2X0N0I2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C009g05586 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C009g05586</name>
        <name evidence="3" type="ORF">BQ5605_C009G05586</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY82674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0N0I2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1212"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="642"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1791"/>
            <end position="1816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY82674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2035" mass="226155" checksum="83E0E97650D9E60F" modified="2018-09-12" version="1">MQTGDSGSAPGARAPPPPASAPTSLPIAGTKETQATQVAGRTATYAAATNSSVVSNETPAQQQDRLARLQALPGILAAIQAVPGNRADRFVQAIFATPDFPSTVATALKFSALNATRNIINPFANALEVSLSHKSTGKASATDKGELVACVRTLLSPNTPICFDTGVPLSGDLEALMPRITGLQHSSTFRTGVLHHRITVGFVSAEARDAALASAPMLVWNSANARFAKAHPFHRNMLEMRINVGVVRPPSKEQIVAAFHSIVQQLSTKGHSCQLVQVLRVIHVDTAKAYAHTVGDFSAFIHFDDASLFQHPTTTLKEILPSRMDLPTRGLDVTAVRHDYEKEAPCARCHFAGHVERCPLMQAANRKEAEDLARHAVMRGAGMVGGGEQTGVGRAATTTNNNIRPTANNNNTSEVVAPSRALGTDQLESRNRFAGLEVEGGQEDDIEEEDAGKEGEEKEQVEEGNEDTGAKADDEDSDSDGNAGAGIDKAGGDNKDDDKDEQDDSSEGSERRGDDVMKDGAEEEDEGMETEVEEEVEQEQGVQDDRIMIIDDGQTTITTVSRESTPRSPSWPPLSPETLAKSLREGAEWDRANAEAAARVQAENEAIINAQLDAQEPLVRHQFAEWGQEDGQLRFINIRGTGSRSNKKMKRSQTVADLSDPSDDPVDVKRVLNRVKGRAGKEVAGQGKRVTRSMSAAAAMQVEGAKAKAEKGQHYRQEHVYIVYPIMIKHLITSWNVRRCMGIPEKRRDIYTYLSTFKASAILLQEHFIKPELWQCIKDEYEGKAFISKHCLTLIPADSPLIDAEILRTHSALDGRILVTSFRLRGDIRILEINNLYAPVDTKQRLTFFDKLHFHRTQSTHLQLLGGDLNDCPLPAIDRRNQGRHGHHWPILIGKLDSPYTDCIRFKHPLTPSFTRPNIVRKRPKSFSRLDYFLLQRTHQKRLVQASTIYDHPKDLSDHRPVSIVLVLSDERGDAAQPNNSLPTTSNQLHRINAATFKTAAFQGMLEGWLEGASGEEPVGELEVVLGNCEKEGRELARREHRERVERMAVLVGRVQDLEALPVMGDEETAEWTRTTEELRRAVNERARQLRIRAHVPEIATEERLSRPAHFQRLYNLEPRDRDHVERLRDDFLAPIRAARTCDDPSSDPLFLRRLSEAHIELLQQPITEDEVVAAIATTHPGRSPGPSGVPYELYHTAPRAWAKALSRAFNAMTERGSLSPKQGQGLVRLLFKHHKIGADRAELSSYRPITLRECDYKLFTKVYVARLNHVLPDLLPPQQHGFVKGRRSADASFHLRLLIEELGARGTEFPDAALLSLDQSSAYDLVEHEWIFAIFDALGAPAAFQRVLRMLYSGDSTTARYIINGFLTPPVRLTCGLGQGDPASSSVWDVVFQPFLDALHRRGIALNLSLPTIHPYPQSRAITSLAFADDVVVAVAGSESLTLLDDLALDWRHATNGRLNTDKTVVLPIGCRWEAGDRPLVVKAEGESLEWIGLSFDPTGNTELANVNLVARLEAVLDSARDRGLTHHTRAFYVNRYAIPKILHILSADIPPLEVVKELDRILVDFVRGGKRRSCYGKDVVFTPRFKGGLGVMRMQDVVDSVAARVWDVLLGGSDAIWQGLARAAIVRTHPAPDFDLATDAWPCDYTPIRTDLHPRWQAVLKVPSTHNAQVKPRTLTLANLLALPIKLHTLHYLPGAPAVSRSPYDADYAAFANYAKVADLFRRELYPGGGFHLWTPPTDVVVSNSEYDQQGRPQREHIVAWYRHAINRLRFTPIAQPVAAVRINGPPRVRPRSEVRPTTPLESILPHPIDPPQRLPRPALPDQSTQYNLLSMDRPYTIRRVRRVLNAKAFTDTIGFRDSLQPDDLKGFWKGVNSKALTAREREVWFKLVRNFTPTRSLQFHQKHDDSPACLVCGAPKDDREHYFFDCVDSRNVWIAARGVLCDALGLDTIENTHYTAVQRMFGLPKLKASLRDQEGAGRTIEIFTGLVLEMISSGRWGMQKWGTRMEGVGRRRIILEERLKLRAGGAWGRRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N228</accession>
    <name>A0A2X0N228_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA primase large subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C007g04791</name>
        <name evidence="13" type="ORF">BQ5605_C007G04791</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic-type primase large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY63326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N228"/>
    <dbReference type="STRING" id="796604.A0A2X0N228"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07322">
        <property type="entry name" value="PriL_PriS_Eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058560">
        <property type="entry name" value="DNA_primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016558">
        <property type="entry name" value="DNA_primase_lsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007238">
        <property type="entry name" value="DNA_primase_lsu_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537:SF3">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04104">
        <property type="entry name" value="DNA_primase_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26466">
        <property type="entry name" value="DNA_primase_lrg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009449">
        <property type="entry name" value="DNA_primase_large_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA primase large subunit C-terminal" evidence="12">
        <location>
            <begin position="303"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR009449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR009449-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGY63326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="538" mass="60516" checksum="695EF5FF151C6949" modified="2018-09-12" version="1">MYAGKRAPLSSRSLNNNTKNSGASTSSSSAAGGAGVVAVKGEVTRHSVRSAKYPHRLNFYERPPQEEITIEQFEEWAIDRLRLLANIEAAQARNKSHDDIRQLVLERSKAHLPLSGDSIKSADVEMERKKDLYSHFVLRLAFCRSVETVLFKIRYESDDVEDRRSFIDSLNFGWDVVGQEEKMSLKKELANASWMKEDRIEFERFFKVDWTQVTDLVARRAVYLQAGKAFVPHREELSLVLAEFSARLSRGLEATLPRLDEDSRLLPVLEHLSMGFEAGIASEYTFTGAEDGEAIRAEMVPALAQQSFPMCMRSLQETLKSSKHLKHEGRLQYNLFLKGIGLSVEEAIVFWRQSFSNITADKFKKDYQYNIRHGYGLEGSRKNYAPRSCSQIIMGVAPGPGQAHGCPFRHYDEANLQTKLQSTYNLDASDTREIMSSVKGKHYHVACTRLFEIQHAKCGVVKGDGIGKGDSVDHPNKYFDRSRALVKEKMERDGIVDSNAVKADAKLSVIQRDEAKPAVVVRPETVEEGSSSAMHVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N4K2</accession>
    <name>A0A2X0N4K2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C028g10454 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">BQ5605_C076g12931 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C028g10454</name>
        <name evidence="2" type="synonym">BQ5605_C076g12931</name>
        <name evidence="1" type="ORF">BQ5605_C028G10454</name>
        <name evidence="2" type="ORF">BQ5605_C076G12931</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000080">
        <property type="protein sequence ID" value="SGZ11750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000127">
        <property type="protein sequence ID" value="SGZ34634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N4K2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ11750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ34634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="73" mass="8290" checksum="765046DCF0D6F669" modified="2018-09-12" version="1">MCKDMSLHVSWPARERAKILDPSAGFGVVWVLSLPLRGTHSFEPILKPEYSLQYLFKDNEYDESIGPVLAILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N7W5</accession>
    <name>A0A2X0N7W5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C024g09817 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C024g09817</name>
        <name evidence="7" type="ORF">BQ5605_C024G09817</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ26012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N7W5"/>
    <dbReference type="STRING" id="796604.A0A2X0N7W5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048870">
        <property type="term" value="P:cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024574">
        <property type="entry name" value="ELMO_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050868">
        <property type="entry name" value="ELMO_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771:SF56">
        <property type="entry name" value="CED-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11841">
        <property type="entry name" value="ELMO_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16457">
        <property type="entry name" value="PH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51335">
        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="2" id="KW-0581">Phagocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0729">SH3-binding</keyword>
    <feature type="domain" description="ELMO" evidence="6">
        <location>
            <begin position="396"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGZ26012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="830" mass="90131" checksum="74D02C7E2E529C7C" modified="2018-09-12" version="1">MASESEVYSPDGGDSFRRASGASDAGTDTDTSAPPPLAPVPPRPAPTVYVTYGARSVKARIDREVPLDEIIAQLVNSQQLAVAEPPALFALREKESGSLVTEENLDRFLDRGAAFVQSALACRSALAQARPSPPVPESSLASHLRAIAVLCPEPGAHLLEPFLIEAVEVVDKLRSSDTAAVKLATFSLRTLIKEPAFLTAFIDRGGMGAIQDVIKGSTGNTLAYALLSSQQLLELDARASHSLGKDFIAKLVQIIATEPLINILRPATQLLRLLSDQGRPSAATPRLDASAGVFAIAFELIQQRIDFLPIVVGRLYGNDWPLALANLELINSLFQGATEMGDERFHVELETLGTSKIVANLLDTWKEEAYIAAILGYQANVVAALHAQLVTPVDEAHYGLFDDIWTASGSDENTVDEATKWQSLGFGTEEPQTEFKASGLLGLKTLLAFAFDRKNEFASTLKNTLARPAPRRCPLAAVSTAVVLALANHFQISDDQQAARSTTLNPYVLQFNQCHALATRFSVRMWTELGATEADFERVATLMKSQIAHVLTIDGSGGKEIKSWDRIRDQFLKADYRSVRDRQVRELETGDDLHSKAPVRHLRGRLYLESFEFVRNQRIACLHEGAWFRVPTPAGTTNGPSASGLKKQVKELVSPTAPSVVQKWRFCRLAANKKALHYLETNGRIAIAPGLDDLPERIMIALISNISPYAPSGELKRQAPSIVSTANTASTGSSQPLTITLRSSDGIIAELVAPNEMTYFEWLDGLSLLRPDGGIVTSQTADYMQALTDIGVKIKLLDLSGEKVDIPNVIDVRQVPACDGAASFYYSENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0ND03</accession>
    <name>A0A2X0ND03_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C021g09314 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C021g09314</name>
        <name evidence="2" type="ORF">BQ5605_C021G09314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000083">
        <property type="protein sequence ID" value="SGZ20944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0ND03"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ20944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="356" mass="39727" checksum="C2B9D58F3B884312" modified="2018-09-12" version="1">MLPFEAFILIDDSLRRAELPAQDPIHHVTLNSDFTSRGKSQPEAYGTTPVRSITLTRAQAETSRSPAALKSPSDPKKGRTTAPPRTADFVTEQHLITLLQKLGPTLKHLHLGELAFTSFRRQHLTQLTPLLSSSNLQTLTVIGRPAIEDQFQFHALASILPCLPNLSTLVIRHIRASTPTPSATMGRIPSFKLVSISVRDCPSFMAEHYYWLFASTMYADSLRVLDFEYPHPRAAPLRPVAWLGWPVRSLRLTTSAKGVIEGFAHNLPSLERLEINATGVAVDIIELLGNLQKPPVELADTSMGEEDGFDPRVMAFVLEVGWPRTQFRKICIRRRQGWTRLEAACKSKAVDLIELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NFN0</accession>
    <name>A0A2X0NFN0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C026g10221 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C026g10221</name>
        <name evidence="1" type="ORF">BQ5605_C026G10221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ27922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NFN0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ27922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="312" mass="35621" checksum="B7F0719303E2BCFF" modified="2018-09-12" version="1">MLAKLVPDILGGERLALDHLEIRIVDTLNDQGTGASVLLLQVHDHLGVGDRSIETVHGPPLSQADVGGPHMPMLEDARIALALEVRLDSNRPQLVIILAELGYLDLPRLLSNDPTNFPQQISSRQGEARFVSLYWIAFRSAPTAQQPALEIQPREAIRRSDLRQVESFEPATRGQSKQETYKQFVFNDARLRGLERPALLRQYIAARVLKEYRTRIQDFDDILARIFTVPIDIAAKHEESRLFREILSPLYQECQRPLPEDEIRTDEDPEGSDRLLRWIQKVLWYPGSRRRHFRQTGPDSGCLGIPRETFPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NPA1</accession>
    <name>A0A2X0NPA1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C012g06696 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C012g06696</name>
        <name evidence="4" type="ORF">BQ5605_C012G06696</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY15905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NPA1"/>
    <dbReference type="STRING" id="796604.A0A2X0NPA1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF444">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13650">
        <property type="entry name" value="Asp_protease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="483"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY15905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="740" mass="82180" checksum="347A75830681E955" modified="2018-09-12" version="1">MISQLLLDPELKVWYSSDAASHVNKKYSTGDYREFSTAARNLQLELGVSLVSDTQLVRMLLLHMDKELSQQLRLLEVIKGTGLSPNKLEASIVKANSTTSSAVFDYQTFDAEARRLWQVISATRAFVKATAQASARTVRSTPMLRTTASPSTLPPLSSKTRAPPMTDRERAFLRSNQGCFKCRKINAGHFKDMCTTWATSACKVPAGWRQGPVSPEQVASLSDAVDKIDNKGEELHCLCNDEYNNGMDDERCKPISFSVKLTTEDGPALRALVDTGASASFIADREVEKLRLTQRKLQVPTSVCVAIQSQRVLHPVTEFVCVPLCTLNGRWSTQHVVLKIAPLTLLKVVLGQPFLKQHDILADCKRQAFGPVSLISEQQAEESQLRALEVAFCKEFSDQFPADIPPVSQYESKVRHCIALKPGMKTPRQPTYGTPMRWRAAWRHLLDEHLAAGCLCPSLSEYSSPAFIIPKKGMDTDPSIIPRWVNDYRILNAATVPDCTPLPLPDKILAVAARARFWSKIDMTNSFFQTKMAEEDMPKTVAATPWGLFKWVVMPMGLSNAPATHQRRVNKALSSLIGKSCFAYLDNITIFSDTMEDHQTHAKEVLEALRRADLYCLPKKTELFRTSCNFLGHVISRNGIAADQLKVERIVEWPERHFNAINAIVTLLPCLKPIDHTDSADPLWVMTDASNVGMGTVLLQGQDWPKAPLQAICSLRCEESTLRSAQDLGARSEPGASAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NSC8</accession>
    <name>A0A2X0NSC8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C011g06598</name>
        <name evidence="5" type="ORF">BQ5605_C011G06598</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="4">
        <location>
            <begin position="477"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="1160"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="63"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="429"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY12775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1346" mass="151353" checksum="C0FBBB23CAB481F5" modified="2018-09-12" version="1">MYQHTVVSAAPACGVHVPIRSHVQALCDTHSRTNFATMPRSQGRHGGPSRPRQVLGARIAPYHGPARAPAAGRPAARPSSSSRTDQQNQSPARHNNNATDLGIATRMSPPCSCAERTASSARWPTRRWARPTTTSSAKASAPGSNRAQTPQAHVSIRDDLGPQTAVCTHCKARHWECERSKSTRHFSACCSQGKVRLPPPPQPNLEYRQLLQGSDSEAVAFRENARSYNNALSFTSLAAHWDQTQVGTLGPPVFRVFGRLYHRLGALIPATRIQRSTLTKLESMLRTGNRFVREFASAKARAGWDTAKEWVLRLCLPPGRDRRTHNLPTSSTEMAMLICDSDTNTGDRGPQDLILQVHGDRCPDGRPKYQIVSSLHPSAMPLRYPLLFPAGEDGFRPNIPLCGFNQAGPPIARNREQIDNGVQLRELLDGLGPDEEDEEEDDEDEGDEEDEENGDGERRRSNKRGRGGSTRVSRSQYFAYHLHERDDYFSIPHVTQRLFLEFVIDGYSQVETDRLNYIRLHQESLRLTTAQGITDAVANGLTPDQIGRSVILGSTFKNSPREITQRYQDAMACVVKYGKPLLFITVTCNPEWPEIKAALGPNDKACNRPDLIARVFEAKLNRLCDDVFGNKQRAGCFGVVLTHTHVIEYQKRGLPHAHILITLAPDDHPLSTEAIDKMISAEIPDPSRYPDLHETVTKHMLHGKCGGNSTQPCMEKDKYGNPRCKRHFPREQNPHTRMHPEGYPLYRRRFRHAVVKGGVIYNDGDCVPYSPYLCANPQHYYVILVPRLLKLLTSLFPFCNSNLVKAKYNAHINVEAVTTIGAIKYLFKYVYKGPDRAVARVERAANGEGAREDEPVRDRSTMWPPVNRLPVHLENQQSVQINPNEPLPLDTPPTRSKLTGFFDLCAAAPDGELTTTLLYTNVPRYYSWNKEKLRWKRRVHDRNVIGRIYTVPLRSGERFYLRLLLEVVMGPTSFADLLMFEDVVYPSYRAACAARGLLADDGEHHICLREAAQIETGDQLRRLFVFMLIHATVANPPALLDRHFASLSDDARYHIERYEDVPVNNQTIRLWTLNKIRLLLAANDRTLAFFDLPKLTKDEVRLFDCLEEWLPRFDRQQCAQDAEAAHARLNHDQRIAFDECLCAVELDAVDQMRNNNLGPQHVFFLLAPGGTGKTFVENALLDTVRARGDQAIAVASSGVAALLLKGGHTAHSTFRIPLDTLPTSTCPVDRESDLALMLRTTKLIIWDEAPMAHRFAVEAVNRLLRDLRETEEHFGGVTMIFAGTPGQIVDASLIKADFWRDVRVLRLTENMRLSSNTDAMDEAQLAQTRDFVEWLLTLSILHTLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NV80</accession>
    <name>A0A2X0NV80_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C012g06850 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C012g06850</name>
        <name evidence="8" type="ORF">BQ5605_C012G06850</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0NV80"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15550">
        <property type="entry name" value="PHD_MLL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462:SF3">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20826">
        <property type="entry name" value="PHD_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="6">
        <location>
            <begin position="291"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="7">
        <location>
            <begin position="776"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="66"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="234"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="359"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="454"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="507"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="616"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="873"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1110"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1469"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1553"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1663"/>
            <end position="1950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="131"/>
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        </location>
    </feature>
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        <location>
            <begin position="148"/>
            <end position="179"/>
        </location>
    </feature>
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        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
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        <location>
            <begin position="512"/>
            <end position="544"/>
        </location>
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        <location>
            <begin position="559"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="883"/>
            <end position="893"/>
        </location>
    </feature>
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        <location>
            <begin position="908"/>
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        </location>
    </feature>
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        <location>
            <begin position="1110"/>
            <end position="1126"/>
        </location>
    </feature>
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        <location>
            <begin position="1149"/>
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        </location>
    </feature>
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        <location>
            <begin position="1179"/>
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        </location>
    </feature>
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        <location>
            <begin position="1232"/>
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        </location>
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        <location>
            <begin position="1254"/>
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        </location>
    </feature>
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            <begin position="1289"/>
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    </feature>
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        </location>
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            <begin position="1416"/>
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        </location>
    </feature>
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            <begin position="1435"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1569"/>
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        </location>
    </feature>
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        <location>
            <begin position="1668"/>
            <end position="1704"/>
        </location>
    </feature>
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        <location>
            <begin position="1713"/>
            <end position="1726"/>
        </location>
    </feature>
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        <location>
            <begin position="1739"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1770"/>
            <end position="1783"/>
        </location>
    </feature>
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        <location>
            <begin position="1806"/>
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        </location>
    </feature>
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        <location>
            <begin position="1845"/>
            <end position="1857"/>
        </location>
    </feature>
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        <location>
            <begin position="1907"/>
            <end position="1921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY16343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1950" mass="204626" checksum="D81F34CAAEED7FF7" modified="2018-09-12" version="1">MSALDLLSQAAFLRQDDAPEPAHPTLEARTSTAHDASNTHVQFEAVDSGTGDIQLDPALFDAVARAGSPQSHLSDSDSSSLVSTVPANATSIPPPQLPPLLDHVVASPQASTSTAATAASQRSFDLRGFPSSSSSHRSSASWLPSDPNPSQSTLGKRSRARTSNTSDASDSPFANSSIGPSARKRTLSSSFAGYGQAAVAAASSTGMQLYTDSSGQASLTSLLGGPIGASATLPMLPPLPTLPQRNPTPPTNKFPSNKVVLPNPAALGGTKRSKRPPSWAVNEDSGLIRCVCPYTADDGFTIQCDTCNVWQHAACVIISMDDVPEEYRCERCDPLGAESRGVDRAKAQEGMRKRLETLENEAQNPSAAIANAPAWSDGVGGGGRGRGGHRGGRRVSMDPSRAPSGINALLNSLTAMTPSEQILDEFFGSKELLPPLPAMTKEEPSKPTFAVVTPAAAPTAATTGGGGGGRGKPRRSGGSMHSIPPAPTGTNATTDASMRMYEPNAAASMTEGASAPAGPSTSRPPRAAAVAAAAATPSIPSTPGQVPRDAIGRKRRQTKQSGLNSASGTPIGSSTRGPRASAGSTPNVSAPPTPGVLSGPNAGYFGEPFSYVDGSSIVTPRPSTANGTKTPAANSDDEDFLSSTGGKGEENRYEAWRYEYTPIERDLIRDDTLVQRLQEIVALDATMMDGSEELETVPEELRPQLELLRERQEASRPRHGPNSKDPLVPLLYDPTPFVVLDELPDPSSVAVKVLPPSSFHLNPPAVAAYATTSSQTPTCPYPRPTMHGLFAVNAISSGSFIAPIRGQIVSLDQYRSDPINQYDTLGVPKQGVRCLPYPWSLAIDSRMFGNEIRFARSGCHPNAVVQAIKIVPAPDTGGPMQPGSPSATTTNGDSKAGAEETAAASNGIGRSTRASTPWTDQKRCSDLSTTLIFGIFATADIGRREEIVLPWDWDDSHIVHALPPLMSAPPLPSGLNERDLEPLSRKMVQVTNTILGTTHCACEKKRDCALHWMCRGAAASLPLSKAALAKPREPFAMILLNALGSGQAFQQQPNGKLAVVGAGGAGYGANAVGGDLVMGPGKPGRRMKKPDVGPLLGLVRGWIVRPAHYPTTNRYGRASSNKSSISDFPPPPPMPQSLTVYEDEDQDEERDRGERESIEALSDLTHESELDSGTKSELSAEEGDVEMGSVEEEEEDDEDANDSFVTAHNCSMDIDNSPASIKATLNRKPDPLDGDLTDDSDLTEPLSNLSSDESNNDLDDDQEEDEEEDEPIRVPSRKTKIIRESWPSKPEKRRPEGKRVEKQVVADMRETKKGVDKLLTKSKRGSAKEVERKVSSSKEVERKKKDEKQDKKQGRQLSPSLPDEPRDQGRIAKASEPLPLFDQDVEVYSARDAPLPTEQGQLSRLPPPPPPPARWSGTSESAESTMQVDPIKEATPPPPKEPTPPPKDPAPPPPVPRARLSLAAYRQRLAQKQTEPVTPVENAVSTPSTATVPLVSSPAVETVPLLFPAVVVQPLSEVGAAVHATEEGELNPGMSSTTGVPAAVAAAFNSLRRSSGAGEEQDAPSPTTRLPPPPPPPAPYSVGNSELAISNAPAPVFSPSLPAGAEPATTLATLTPASRPSFTSAEDILKSIGDYFSKSNAPAPAFASRSPALVAQQSLLRVTAAVSPSPPPPPPRPLAVLPSPPAPPAPYVSPPRRSPTPERPMPSWRTSIGVSSAVDPSSPVVGASGGAALGFDISTPASFESSRYSRFDVPSTTSRWGPATASSSTPGPPPPPPPPPPPLSSHRSRPSITTSARSPPSPPQRSPSSSSNFPLSSRDAPSSSRPAPPTRPFDLDSVPTGPRAMNNNGSSSHTRGWSISPAAREAPLHPPPVAGSGSGSGSSDRRVNGPTWAATLTSSSTGDSGVPYGGGYRGRGGGGGSFNLSRGGSRGRGGQVWVPRGIRGRGRGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NVT8</accession>
    <name>A0A2X0NVT8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C002g01224</name>
        <name evidence="5" type="ORF">BQ5605_C002G01224</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS25 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY31369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NVT8"/>
    <dbReference type="STRING" id="796604.A0A2X0NVT8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.63.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004977">
        <property type="entry name" value="Ribosomal_eS25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12850">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03297">
        <property type="entry name" value="Ribosomal_S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY31369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="97" mass="10747" checksum="6DB188644FC6F6A2" modified="2018-09-12" version="1">MRAKAGAAGKKKKWSKGKVKDKANNAVVCDKATFDRIMKEVPTYKLISQSVLIDRMKINGSLARVAIRQLKKEGLIKPVVHHTSQLVYTRAIAAEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NW66</accession>
    <name>A0A2X0NW66_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kish</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C002g01384</name>
        <name evidence="10" type="ORF">BQ5605_C002G01384</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in the early part of the secretory pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Golgi apparatus membrane</location>
            <topology evidence="2 9">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the KISH family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY32596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NW66"/>
    <dbReference type="STRING" id="796604.A0A2X0NW66"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051523">
        <property type="entry name" value="KISH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009653">
        <property type="entry name" value="Ksh1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13229">
        <property type="entry name" value="PROTEIN KISH-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06842">
        <property type="entry name" value="DUF1242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015797749" description="Protein kish" evidence="9">
        <location>
            <begin position="27"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU910717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY32596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="71" mass="7927" checksum="C99AD3D2E2A32A23" modified="2018-09-12" version="1">MTALFNFESLLLVILLIICTCTYVRATAPDLVDRNKDGFLGVFYKCARIGERLSPYVALALTVVAFQILLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NZ78</accession>
    <name>A0A2X0NZ78_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C016g08270 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C016g08270</name>
        <name evidence="5" type="ORF">BQ5605_C016G08270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY21747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NZ78"/>
    <dbReference type="STRING" id="796604.A0A2X0NZ78"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051556">
        <property type="entry name" value="N-term/lysine_N-AcTrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919:SF8">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="30"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="158"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="182"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY21747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="287" mass="32348" checksum="403E78CD39B1890E" modified="2018-09-12" version="1">MSAILDSLPTLAKEPGVTINGKRTRVPARVALGQVTPNNLGTLKKLNWVLTTPIQVLFPVNYSDKFYSNLLEHNLEPYCKLIYYQDLPVGNLVSRLEPLTTETESLSEAKPSTPSTTTTTTVPTRPHVQLYIMTLGILSPYRRQGLATKLLHSVLQAAERSHEPIPPKPTFPSQTDPHSNQPPSSKKSKTSASSAPPAKSDKDQEEEEEAAKKLKKKQENQLREWQLQAKSEIVDSVYVHVWKGNPEAKAFWEKHGFEMSGEIKDYYRKIEPRDAWVLSRKITPKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P098</accession>
    <name>A0A2X0P098_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C018g08606 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C018g08606</name>
        <name evidence="1" type="ORF">BQ5605_C018G08606</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY25365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P098"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY25365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="128" mass="14319" checksum="62D8A80E206453BB" modified="2018-09-12" version="1">MPRASSRIDVGHLPHSRPDIEVTTDFRQWNILSGRGKVSRRSSQMRAINPRLITSFSSTFASLTGVVSKSVQDPPCAFPATAISKGKCNVWTIIVFNEAHSHRSLLHTGDSNSRLTRHRSNLFHLELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P0C5</accession>
    <name>A0A2X0P0C5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C018g08725 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C018g08725</name>
        <name evidence="2" type="ORF">BQ5605_C018G08725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY26353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0P0C5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1410"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1631"/>
            <end position="1656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1411"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1421"/>
            <end position="1431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY26353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1656" mass="185103" checksum="975C611EECC7ACD5" modified="2018-09-12" version="1">MYLDNLDIELLDDDLERMAPLLDLSWSTDEPLEFDTLPRPFDAWRDKFKDRGAIIAARNQGYRSIAIAGHRLPFGVERIWRHIDYAERMRSIVISSQGWMKSYLGVNIEDQPLIVKALEVLPSLIVEEQYTPSMILGCSASLRTLLDFVGTTWLGETAMDVAIASVLASSRVEASTAPDKVYGAFPSDLMAILVASKKHHPDSPQRDVLDKYTFTSPLVPYRTLADLRSFVRARPQSIWFLPLCFRNHWAMARVDVEQRTWSVFNSLSNVRIDEIARNSALALFDYLELQILNTEPKQGRMFHRLATFAIKSQDLTHDLPAPIAGIDKNDLDVGVFEEMAEIENDEQTWSGICFRSDSETDDDCTTDDDCTTDDDCTTDDETPKSGESITARRARLAKEHLKDIEYSKARPAAFAEFKAKVKQLCPGSDVKIANPRTVQCGRCRTYQKTKTRHGVTRFMRHINQNPPCTNMRKIDHYFAVRPPAETAVRSQGKTLEDSPPCPGLTGKRVERYLSKSSARGGGAPSRLKLIKRRFPRLGKRVLTPSERREINNLEANEWMWVNDHSAPRVNSIDCTKIGVESQCGTKLEPCAKCKALLRTKAFSQALHRPRAVGPTIKFTNKRLASVEALMSKVFKEHQGLEELLGTKDGKVYLRFAQGLVSGELAGANILKGMAKVAVIKHRRDAQGKDMRGYVRDEALLDFEHALALASPTALRVVQKTVGGVSMRTLQQVSDLIYPSFLQATDDSKPLRQHRATFEKPRFGLDEPHMQRIIQKIFSDGKTFNLHVDDTKLRQVIRTTRIYSKDKEAEDRLRGQKIFRHELIGMVDPPIVYETTRELEGIFRGPNPPIAGTKVRVYMLAPNDVSCPAQYLAAFVIGDSTSSSEAADELESVIQFLVNAGLGHLLASISADGAASEGVLQRVMAERLGGDEGYTGEGNRRRELAHVIPSPGPDKVFPAIRLVSVQVGNTPTCFKRDEKHLSKNLRSACDSGARAIYGGTGCIGYRDLLTLLDVEESARTLYLRDVIGRDRQDDNATHRAFSEATLSLACRLHEDGKVDADAIVFLFLCGELHDAIQNRSLQPIERIKMLLTVRYTFAGWLTFVRNRPGYNAQSFVAKETLDGMRKVVDTNIALTRNYRDFWSEEAFIPWRHGTEMVEHFFGGLRKVVQEFDALEFLESASKVTALLGLMRKLKTETAGSRQGYHHTYDRLDDLDLVAMRTSPNDEEIRSTSLVAAGLAKELLLGLRMWDTIHYQKSNQVEEEIPVNASEPWHFEPEDAEPLSYLADLDRTLNGIRTKTCQGLVVLDPKERKSVENAVRSLASLGLDNDAALLAVQQAYDEADAQAEERFLLDAIVTANESLPGHAQIIRLPSLLRHDSRQLALDLKSLIPHRRAHQCAHLRAVLLKGRHGATTSTAQDSDPTSKAKLSEHGEVHSSVLRGLVQSMGAARLEAVSGVARSIRWTGQGTFSRFSTANETDNIGYIEDGRKEVRMQLRARQYTVFAKIPTFGSIDGNVTSAMPLKIGSLVCFRLKRGIIPVSCDASNIGEEQLSIGLVRYMYAKATSNHCDRAETDSLALLSNVVLQELRVDLVAYLGERVFDLSQQAEARFCFLRRYNGLRDASVSLSNQMKGVKDVGSKRKAASADEEPSAKQNRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P173</accession>
    <name>A0A2X0P173_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C002g01129</name>
        <name evidence="8" type="ORF">BQ5605_C002G01129</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY30205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P173"/>
    <dbReference type="STRING" id="796604.A0A2X0P173"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024789">
        <property type="entry name" value="APC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024790">
        <property type="entry name" value="APC4_long_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260">
        <property type="entry name" value="ANAPHASE PROMOTING COMPLEX SUBUNIT 4 APC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12896">
        <property type="entry name" value="ANAPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 4 long" evidence="7">
        <location>
            <begin position="416"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="41"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="715"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY30205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="999" mass="108505" checksum="CEC358F812C47D29" modified="2018-09-12" version="1">MAQAPPPPPTLVTHAQRNLPTTTSITPCACCPTRDLLALLSSPSASPSASPSASTSSTNDGSTSTSNSGRGKLSLYRTTGQIDHVWEFAPSPSPSPSTVTVTAAVAPTAPVSKFAAFGKAKAKAKAVQVGIDAMAWSPDGHHLAVLSSSSPLPGTTLSNLEIVALHQPTPKSLLPPTSIPSNEKAFSKPSHLAWHPLTTVKKPEPSPENLTYRRPPHPEWTYRPLRSSAQALIAKLPALPDLNASNASTALIGATDPNSSSGSGSVAAGTGGGPGAARAAIFGAKNAMLQKEREKDMGKPLLLNEAAPRFPTLLEESRVKGEQGEGSVLVVGQGGGKVTIYYGGSVMLGTVDVGEGLDQVQVHGSTTLPWDETQAGTALRNPPRGTFRISLLVSSNDPADPTSRDWRDRQINFDLPPTLHLLMTQSTELHRHISHAFEALQSVRTLWDEARRLGKSWLSRISEMSKAHTITTSPITQLLLLLLTGRPSAALHDFLASKMNEKSLSKWQGSMAQVLQRLKSVPYMSLQPAIERAVLLLEEVESWAMWKEKWGAFGLELGEVRRCLRLGTGVVKACARLERVVVEEERCFEAFGAWLHYELEKVAAQEGSEIVPIANFTPLPVAYYIRHCLPVEVNSILPFLNFGPFSASLDTNVDLIRAKKWIDELEVVGKRGKTREEGEEELRNVLKRMKEELKGQITAERVEATAEDWEGTVGGWDKEGLLGAEGLEPPSKPGDDAMGDDVVPPTAPGSANKAKLEEDDISVSLPILLHLLAGRVARIMDQAITAVGAPRVQEKPVVNPESSGVEVITRTSRERVLYREQTVRNDVWRVWIDGEVFRVVKTIYSTYTEASNIQLGALARLVDERDCRLEVIDLAWLDLDELVMICRIHEGKVTSHYLLSVCMSALSFEPLTSNPCRATPIQDSPTQRIPLHRNLLFEPQFPPEGLSIQPYREEEDGSTCRSGAPVACVLAGDGRRLQMAVIEGGLLENYDEEGDEEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P1V8</accession>
    <name>A0A2X0P1V8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g04117 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g04117</name>
        <name evidence="1" type="ORF">BQ5605_C006G04117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY56245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P1V8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY56245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="134" mass="15593" checksum="C2074BE35B4C5989" modified="2018-09-12" version="1">MLPCALLLKDWHTPANTTVTPTNGAVENLPWMQSMSRDNSRMQCHQLTVKKQLESCSDVVSSNWQWNELRWARCEEQEGERWRSLRLSLNWTHRMLRKAVERHGVKPKAEGHVPGCFDGKWNLGERRRNGLSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P404</accession>
    <name>A0A2X0P404_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C004g02651 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C004g02651</name>
        <name evidence="4" type="ORF">BQ5605_C004G02651</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY66261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P404"/>
    <dbReference type="STRING" id="796604.A0A2X0P404"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39466">
        <property type="entry name" value="RGS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39466:SF1">
        <property type="entry name" value="RGS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="565"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="274"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY66261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="589" mass="66004" checksum="F7E1850526BA4A88" modified="2018-09-12" version="1">MATNVESNDVGEVRVPVEEVTTESGGAMFQAPVPTNEQRNGVTLEEIIGGTRCSPLTLKEFEGFLIHEERSVENLQFVVWYRSYCERFNALPPEYQALSEPPAERYTHFSTPAGSIRTAQSINEKDGWWEKLRGRARSISGRSVRSLEGNIAANANSSEYFSESAKIAQGNGDAAIVEMNGIGEKPSATKALEDDDNLSLHSAIAPDMPNFAEASTFPTTNSIHNKNLERTQTGGFSDASSVNTEKAKQRFGLRFANLAPLMSIRSWKELPVDTPLPFLEEIKLIRSTFFLPGASKELNIDARLRKHVLKSLQPVSEDGTKSEPITTHPEVFKEAADHVYTLMERSLPHYLQWAKGNTNTPKRLFWTGVGIFDMGLGVMFACIIIYFARSRWWRIFAFFFFWFGSMQTYSAIKYFCSQVHSRTARQLYPWELTEALSTGDDFARPTVASTFVMASKEPDTDSAAAATDAAARAAKERADLEASLPFLFGEPESPVEKKASPSGKQTTEEKEGHTTTTRKRIAQFRSRFWATLKTEDGKRVPMFGPERVVEDPYIKDLHDKQMKEIIIFGTICTILFLIIIVAIPEKRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P4N3</accession>
    <name>A0A2X0P4N3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rhomboid-type serine protease</fullName>
            <ecNumber evidence="10">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C004g02901</name>
        <name evidence="13" type="ORF">BQ5605_C004G02901</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Serine protease involved in intramembrane proteolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="10"/>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY68592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P4N3"/>
    <dbReference type="STRING" id="796604.A0A2X0P4N3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002610">
        <property type="entry name" value="Peptidase_S54_rhomboid-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936:SF69">
        <property type="entry name" value="RHOMBOID-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936">
        <property type="entry name" value="RHOMBOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="525"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="551"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="582"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="604"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="635"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="703"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="12">
        <location>
            <begin position="484"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGY68592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="721" mass="79893" checksum="0EEEA902E055E2B7" modified="2018-09-12" version="1">MSKHHQNSRYSPPHASEDPDASSSSSGRAAAPPSRERSQYHAQYSSPHVHPSDLYARPRPPSEAEFHFGDDDTIVPGDSVSQLGRRLTQSENKRVAGPRPMELETVHASPDVEEYSPNEATGPRMPLSVPSSVRSPRHYESSKVPFSSQKPYRGQSSLGQDHSRSSPASYDDDAGMIRKIPSPSERGYQVPYPHPDNKETLYASRRGHASDENPLTAPLVDNYDDEALHPRQLNDDDDRSIYPSSRISRGRETPLWPDPNTLPRRSHPMHSNSVDTQQTYAKDYYDDDYNSSKDATYPPDLYNSKSQWAHDEETNPDAIEPLDVVGRQSDSVDASLIQKPSVWKRMIYDGKTPIALRIAEHKKGEGIQKRPWACWLLATSFCALLAFEMVRMFQVGLAPAMKSLPGYELILRCCFNVMVGPSGPVLINTGARFAGCQKYIANVTDIDWICLKDSNKPATATFETMCTMSQICGFDGFATPQQADQTFRFVVPIFLHAGIVHLVVNLLAQLFSSSIVERQMGTPKFLIVYFLSGIFGFVLGSNFSLVGQPSVGASGAIFGTHAAILVDLLAHWNIEFRPLRKLVWLIIELIVGLALGLVPGVDNFAHIGGFCMGLLTSILLLPIIHQTKRHRGIFIALRIIALPLAIVLFVLLLRNFYVNDPAKMCHWCRYLSCWPTAANNKCQGTGLSTATTTTTTTTTTTSFMLSTLISVLISSFVIPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P577</accession>
    <name>A0A2X0P577_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C004g03091 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C004g03091</name>
        <name evidence="2" type="ORF">BQ5605_C004G03091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY70022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P577"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="613"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="413"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="531"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="550"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="573"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="622"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY70022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="661" mass="70903" checksum="67CFD4B734DFAE43" modified="2018-09-12" version="1">MVNNISHRRPSLPLVDGATARHASDAPGRPSPSINFVTTTSRTDSIPSRSSSHASSSRSDSLSQLDHGEGAATNHPTSAVRTRTHRTGSAPPNRMRKSALARIMNMEGLESQIHVDPMRSDSLRHFDSATSGASGSWQGGDSELTDGRRTCSTLIDTVHPQPFPDASRSPHSKFKALLGRGAHLSLEPRQQHDPPSRSPRGDDAPRRPEMSRTVSEPGLKGRHGRAKSVSALFGLASSQEDGIPPLPKGSHRPDAQSESVPELSTPVKTPAARPPSSWIRQRLRPSSSSLSLGTSRKSPSLSNSVNPNRTVGLPSTPSSTSVHTIQSSAQSQSSTAQSWQSKSDFGFIKALGSFVAGRLQTKVDDPISDEELLRWRKPTLERDRAPGELGVNERFLTNSELGSSGREYRESSRASSLSNLQSRETTEEEILVIGKSGRSGVKSTSMVSRTTRQELSAMPSSIMGVCHFQESETRTCWADSAVPLKSSHSNNHMQHSTCRSRFGDEQMGMRSGSKTSYPATSSPYLIENRPLRSPRSSPCLPRSKSTGMEAASQLAASLSLHTPSKSRPPPLPLGLAPRPAAAPRRKPPTGRMSTPTVGEARRIISNEAWEQVSLSARKTHSTRSVSASSAASPPLTPSSSSRTTANEISVVGVQHASSVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P793</accession>
    <name>A0A2X0P793_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase II subunit A C-terminal domain phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C008g04904</name>
        <name evidence="10" type="ORF">BQ5605_C008G04904</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">This promotes the activity of RNA polymerase II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY78637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P793"/>
    <dbReference type="STRING" id="796604.A0A2X0P793"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17729">
        <property type="entry name" value="BRCT_CTDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039189">
        <property type="entry name" value="Fcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011947">
        <property type="entry name" value="FCP1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02250">
        <property type="entry name" value="FCP1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081">
        <property type="entry name" value="RNA POLYMERASE II CTD PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081:SF36">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="9">
        <location>
            <begin position="162"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="8">
        <location>
            <begin position="573"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="395"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="456"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="666"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="747"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="506"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="670"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="754"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="786"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="797"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="855"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="871"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="913"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY78637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="922" mass="100232" checksum="C1480C0DA2840FC6" modified="2018-09-12" version="1">MADQSSFTTLFAPSSLPFPITIQRLLVQQPHSPITKTQALFTYSFVPRTGAPGPSDGKAERLSKVYESPIEGQFEGWADRISHGTVVRDTNVPLVYIKEDCTHDVQLHGLCALCGRDLTGTDYTGFSETSRAKIAMVHDVGGLTVSLEEASRLEAATTSRLLSAKKLSLIVDLDQTIVHATVDPTVGEWLADSDNPNHEALDGVKSFRLGMTSGDQSVDDGCIYYVKKRSVSQSVFKKQVEMLSNHVVPSCALYHTSCRPGLDQFLADLAEIYEMHVYTMGTRAYAIEVCNVIDPDGRLFGGRILSRDESGSLTRKSLQRLFPCDDHMVVIIDDRADVWDGVPNLVKVIPCACYNYGIHSRTIDPLTPLPTVLWFSTDEFFVGIGDINSAFLPPNPSPSPLLPPSSTSVSSSTSPSFSTDTTDDSTIISLSMSEAKASTAQVLTEQIESRPLAAKALEQAKKEGSSSSSSSSVKPVDRAELDSDDDDQEDEEEEEEDDDEEDHSTKTSAQDVVRSTTPPPREAVLKDDDRELIRLFDILKTICDTFYRPGTSSTSSDGDPTTTSDVKNIIPSLKRRTFSFTSLVFSGLVALGTPASQSEWWRLATLFGAHCAESISSRTTHLVAKEAGTAKVHQAYSMKCIKVVRPGWLVDSIARWEKLDERAYLLITPDDPDPSGQDEEDEDEEKEDDQLLRLVEAGLPLGGGDLDDIDGFDEEALRRMAEQDDLDAELEEVDWANAEKEIEDALAESEYDSDASTGSARTSSSAKGLMVGSLVGKGKKRPRPSSLRSNGGSSTDDVERGGSSDSRLKSDAGGKKDQALATSSGVVADSPLQKRVKTSRMRSSNLLKVSFPHDVNFDSEARKEGGESGDPGTTNTSRASSRNGETSSELGSGAEDDDDDEAFFASMAEEVEKEWSGRTDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P7A8</accession>
    <name>A0A2X0P7A8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g03751 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g03751</name>
        <name evidence="2" type="ORF">BQ5605_C006G03751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY53360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P7A8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY53360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="447" mass="50240" checksum="C363924AEBD3E765" modified="2018-09-12" version="1">MSCTTFTDNAASSSRSKPQQGFAIRRAADQILKAKQRIFLPPLGCRLFNGLSRQTPWAQPLDPTSSGKEKAQTPKLRLPFVLRTQSGKMVLDLKFKDRVSYARDVDQGKKLVARLIRSSWSHDSVNCRTLFLDKLQKEYHNSLFAPAIKILEGLKTVGPLLRLCSASYKAYVWLGDILENLRAQYRPKLVAFLEVNPGFKVHGKRIPFTRRVKPKENNSGGRNGGARSSQGEQVRLVFVFRAADTDACTPVQQLRFDPEEAEMCEEEQEEEQGSEGEKERAGTDYDDDDDEYSETMRLAEQTYPTLPNAPALPTRLCWLGDTGADDLSRDLQRLLNSATELCRYDKTFSSTQKHVHPHIKIFAQDLAKLQLSAETNGLNRDDLDNGGAQFGHGKLGLTELAETREHLANWPNWSVREVVTRLWNCIAAIARDEFARALTHMATGVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P7P2</accession>
    <name>A0A2X0P7P2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g03891 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g03891</name>
        <name evidence="1" type="ORF">BQ5605_C006G03891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY54593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P7P2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY54593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="86" mass="9254" checksum="F7CB06462532B3DE" modified="2018-09-12" version="1">MQPSACTCQCCASFGFDCVSLKEPRPTLDVPASEVCFPFACTCQCCASLLFACVSLKEPRPNLDVPASEVCFLCCLLVSKRHALQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P832</accession>
    <name>A0A2X0P832_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C008g05244 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C008g05244</name>
        <name evidence="2" type="ORF">BQ5605_C008G05244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P832"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="481"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY79886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="510" mass="57683" checksum="BA4E04A11CC84E67" modified="2018-09-12" version="1">MGSVLTSSATVQTQQHHISASSIAEDGRSTTLASRPTTSNSSNSMSHRIEEVQDEIRALHDAVRALPSTSRLSSSQKETHVLYNLQRRLEKMQYCLRHGVRDDDLDSYTPPATRSNDRNDWNDFKTSRFFRCLLEKNGLEGKCSVCLPDSSQNRLLSITRRYSDRQIHHSDPYKVPKDFSALQAIGSRYWEQVKNSPELWEQWKEARASEARDRKETARPLKRWQIDSATISKLRRRYENAMNELVREDSALRFRLLGGQLEQAREQKNDCFIVSTLGGAAFMRRQGWDSDQQKDILVNFTDCVNGTRFNQEQNEQYKMRANHGDVDKASQRVLCAWYSIIIDDHYSEQPFHGSAPTFCSLVLNICGRADQALRRRHQRNRSTQPYVLSKLTSYNQATLAKDPIALIVEFGNGLQERDFRSPTNGKKPTVADLRRIIPLMRQGGLTFSLKEEIGQGSFDRTRAEGTVTTGQLETKPEDQVSGSDSASASDLGSDSNSNSDSDADLGAATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P851</accession>
    <name>A0A2X0P851_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C008g05274 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C008g05274</name>
        <name evidence="2" type="ORF">BQ5605_C008G05274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P851"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY79990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="106" mass="11905" checksum="511E77CAD8D3AD07" modified="2018-09-12" version="1">MPGWGGHWYTRPVPTSNRAKKQKSCLYSPARGSSSGWVNGPADLARAHRVDAGRSAGFSRYFNYSYPVFISTASVTTPHGYAEKFLKKKKNFGDAHDLLRIVNWRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P8A8</accession>
    <name>A0A2X0P8A8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C008g05354 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C008g05354</name>
        <name evidence="2" type="ORF">BQ5605_C008G05354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY80311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P8A8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016122240" evidence="1">
        <location>
            <begin position="22"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY80311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="134" mass="14484" checksum="EB230ABE6A7DEF21" modified="2018-09-12" version="1">MLFKLPTFALTLALLSVQIQALPTYGSHLISPLDGQTFKVGDLLPFKYQTNVKVAYQIQLQHADGSDILTFATDITTDVNTSIIAAQFLVPKPHNISHRSGPVQAKLAVLQSVPCTEDSSVYMVAQTVALTITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P9F2</accession>
    <name>A0A2X0P9F2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C009g05755 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C009g05755</name>
        <name evidence="3" type="ORF">BQ5605_C009G05755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY85404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P9F2"/>
    <dbReference type="STRING" id="796604.A0A2X0P9F2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3110.10">
        <property type="entry name" value="protoporphyrinogen ix oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.20">
        <property type="entry name" value="Protoporphyrinogen oxidase, mitochondrial, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF17">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="496"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY85404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="570" mass="64147" checksum="45887FC2795C57FA" modified="2018-09-12" version="1">MKIAVVGSGTSGLGATWLLNEHSKHEVHLFEADSRPGGHANTVRYRNPLGDDYINVDTGFIVFNTVTYPNFLAFLLETGVPYLSSDMSFSVSRDRGLFEWAGASPAALFAQPLNLLNPSHWRMAWDILRFNVGALEVLQRGDRGESIGDYLARERYSQTFIDNYLLPMTAAIWSTPPDKAALDFPALTLIRFMYNHHLMQILDRPTWLTVKNGSHSYVNRILERLDPAKYHQGHRIESVRTGGKGRKVVLKDSEGNETDWDHVIFACHADTTLKILEKGEGITEEERRILGGFEFSKNRAVLHSDPELMPKRRIAWSAWNYLTASDGPKLNVNSVAFFCPLPTRTYWMNLLQSIPEAIYGPVLVTLNPPFEPRKEHKFAEWDYDHPLFSEKVRALRQAFHLSDTHDIDRDFLGSGPVQSVRSQDELKKIQNKRGITFAGAWTKYGFHEDGFASGLRIAVDHLGAQSPFPIRHAERDLNLSRTDRYLNYTFSRIDSLARIFSFPATVFLFVLMIGLSVTRMVITVLGARSIAAVIGDVIMMLQRSNGASTAPVVKLNGLKRAGAGVRDKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P9W5</accession>
    <name>A0A2X0P9W5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C039g11829 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C039g11829</name>
        <name evidence="2" type="ORF">BQ5605_C039G11829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000060">
        <property type="protein sequence ID" value="SGY90806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P9W5"/>
    <dbReference type="STRING" id="796604.A0A2X0P9W5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY90806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="479" mass="51570" checksum="1487BD6DCCEC9A3C" modified="2018-09-12" version="1">MDDDTLEKLYLLDSVHRLLSPSLPSPPPSPRQSTVLEAPASSFVLSSAAGDSVSSSATARATWTGGARAPAPPPPIGLGFEPSHHSDLLHTHGTLPSKRARLSPSAPPSHSALPPPPTADRARRPSRISFEGTNGLTPDIRATPRIRPPVTHDEPKVGSEDWTKNFSKDRLRKMAAQFRATGRELKHTGDKLARESTANHAVALAYQTDAILLYVFAFWCDDQAAKMCIAQNWQTIFGLVAYVKRAAREAKLGLLEGICTRMESIAVYTLAMYEQKQLNHRGAQLLASGAAASSSTKLPVASSSVIVPPRLNLPPPPPSLPPRPGPPPACGASQDSQSPASAASPPAMVGSGSAPAPAGSSIEVLKQFVKAGSELFRYHRLWDEAAAHFSPDALARSLPSTLELCLQSSIWIDPGTFVWPQPRIREEGEEGGLHTWVFAWPVELGKPMMVVHTVAFMRCMLQEWARENARGFTLTSVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PBA5</accession>
    <name>A0A2X0PBA5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C033g11148 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C033g11148</name>
        <name evidence="6" type="ORF">BQ5605_C033G11148</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000066">
        <property type="protein sequence ID" value="SGZ01466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PBA5"/>
    <dbReference type="STRING" id="796604.A0A2X0PBA5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="19"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGZ01466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="337" mass="37152" checksum="7A36541E0BC2F3F0" modified="2018-09-12" version="1">MSLGRNFTLGSSAIKIPAVGLGTWQSEPGQVRKAVASAIKVGYRHIDAAWIYGNEVEVGQGIVDSQISRSDLFITSKLWNSFHSPERVEKALDETLHNLGVGYLDLYLMHWPVAFGKGKAEDGKSPKVDQELTKDPMPTWRAMENLVDSGKVKNVGISNFSIERAKKLLEQARIKPAVNQVELNLRCSQPELVKWSKENGILLEAYSPLGSTGAPQLEDEVVQAIAKAHNVGPANVLISWQVQRGIVCLPKSVTPKRIEDNFKGKCIGLAEASSQSMTSHYFLLPLAGYADIELTPQEMEKLEARSKELGHTRTVDPSRAWGVDIFGEGSHNKKRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PDA5</accession>
    <name>A0A2X0PDA5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C005g03547 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C005g03547</name>
        <name evidence="1" type="ORF">BQ5605_C005G03547</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PDA5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY77051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="75" mass="8338" checksum="023A34CA09EDD18B" modified="2018-09-12" version="1">MANGVVGLDSRPHEAKYHQMAQYTCTFDARHGTVHCHPFVRTFVEAVGGKFQEITPLVNQKGERLPRATMADGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PGD3</accession>
    <name>A0A2X0PGD3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL34m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C039g11763</name>
        <name evidence="6" type="ORF">BQ5605_C039G11763</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL34 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000060">
        <property type="protein sequence ID" value="SGY89697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PGD3"/>
    <dbReference type="STRING" id="796604.A0A2X0PGD3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3980:FF:000001">
        <property type="entry name" value="Mitochondrial ribosomal protein L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00391">
        <property type="entry name" value="Ribosomal_bL34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000271">
        <property type="entry name" value="Ribosomal_bL34"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01030">
        <property type="entry name" value="rpmH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL34M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN 34 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00468">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="24"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY89697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="56" mass="6720" checksum="BC602A1D1D049A16" modified="2018-09-12" version="1">MHPSLLPPRLVTYGCEYQPSQLKRKRKHGFLSRKRTKNGRRVLEKRFAKGRKFLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PH94</accession>
    <name>A0A2X0PH94_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C036g11550 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C036g11550</name>
        <name evidence="2" type="ORF">BQ5605_C036G11550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000063">
        <property type="protein sequence ID" value="SGY96205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PH94"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="68"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY96205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="471" mass="52464" checksum="2D4B6B7B7C634A33" modified="2018-09-12" version="1">MSPFTWFTPGSFTIACPLRLKGPTKDPQNWSQAVKSGKEDIWRQAAADEFHSLATEYNCFTPVDSSLLPHGAKVLGSRFIFRTKHDQLGKITSHKGRLVAQGLTQRPGINYDETFAPVAKFTSIRALIALAAAKKLHGHQADVDRAYLHGELKEDLYMHVPQGVDMPGKVLKLHQSIYSLKQAGRVWNEHINLTLKSLNYSATAKDHCGYVRRDGDQYHYIALYVDDLLMVSPLEDEIKRTLNGLEQKYGIKQLGPAQYILGIQIKRQADKSIILLQEAYITSIPNQFGMSDSSTASTPMAPNRQLEPLLAEPSTLARTRYMQAIGCLLYAATGTRPDISYATVFRYLRGTTTLGLHYTSEQGKFSGFSGFLGYSDADWGACPTSKLGIDTQAPIQLYGDNQGALALAKNPTLHHPSRHIRICKHFVRDQVRLGTIRVDYVDTKTMVADIFTKALGPLVFKVHRENLGLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PIA9</accession>
    <name>A0A2X0PIA9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Histone deacetylase</fullName>
            <ecNumber evidence="2 10">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BQ5605_C030g10815</name>
        <name evidence="16" type="ORF">BQ5605_C030G10815</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2 10"/>
    <dbReference type="EMBL" id="FQNC01000069">
        <property type="protein sequence ID" value="SGZ08768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PIA9"/>
    <dbReference type="STRING" id="796604.A0A2X0PIA9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000001">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF10">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="15">
        <location>
            <begin position="37"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="402"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="474"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SGZ08768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="552" mass="60252" checksum="84C8EB1093495DC6" modified="2018-09-12" version="1">MSSTAAAGIMTPVTGAKKRTCYFFDSDIGNYHYGPSHPMKPHRIRMTHSLVMNYGLYKKMEIFRAKPATRKEMAQFHTDEYVDFLSRVTPDLIEQAAEGMGVTGAGTGAARAGGISREMGKFNVGDDCPVFDGLFEYCSISAGGSMEGAARLSRDKCDIAINWAGGLHHAKKAEASGFCYINDIVLGILELLRYHPRVLYVDIDVHHGDGVEEAFYTTDRVMTCSFHKYGEFFPGTGDIKDIGYGKGRNYSVNFPLRDGITDEAYKSVFEPVISQIMEWYRPSAVVLQCGGDSLSGDKIGTLNLSMRGHANCVQYIKSFGLPLLLLGGGGYTIRNVSRTWAFETGLAAGQELGGNIPMNEYYEYYGPTYQLDVPQCNMDDLNTREYLEKIKTQVFETLRHTGAAPSVQLQPIPRTAMDLDSDDEEEDTRDPNQRRSQHSRDAQIQRDDEFSDSEDEGEGGRRDRQSWQSLGTDVKGNGSVAAGSANGAKMMGGTPSIEALTTPGQAEAEDVEVPKGGPGEEENLTVSAARRTTVAGEGEDDGQGGDGDVSMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PMW7</accession>
    <name>A0A2X0PMW7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C026g10172 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C026g10172</name>
        <name evidence="2" type="ORF">BQ5605_C026G10172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ27722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PMW7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016003215" evidence="1">
        <location>
            <begin position="19"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ27722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="139" mass="15250" checksum="9C9A2E668950CD30" modified="2018-09-12" version="1">MKMISVNLTVMSSSFVAASCATEGRMHTGGTEMYCHKNSSGRATLGSKPNNSQSSGKIFWNKLSTFKGLRSSTALSMCGAKSFVSWIDSLNMARQVAYVPAVSWDPSWPTSRVLLRPRNFSCPMRMGPIFLTTPLMEPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PN18</accession>
    <name>A0A2X0PN18_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C026g10232 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C026g10232</name>
        <name evidence="1" type="ORF">BQ5605_C026G10232</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ27969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PN18"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ27969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="154" mass="17310" checksum="81F31BA47EB55B22" modified="2018-09-12" version="1">MSVKQLADSLCVLFCGAKANLTELEKCRLMIVRQGKVERMLEWLSHVCVFSREHLPPERQQPQHLIREISLELVTSEALATQGLESKLRCLFSEHAATACNLGNGQSIEVNMPNLMVKPQVVFIHHQLIIPKSLGKCTGGQTAWENFLDLPNYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PP91</accession>
    <name>A0A2X0PP91_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C111g13220 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C111g13220</name>
        <name evidence="2" type="ORF">BQ5605_C111G13220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000105">
        <property type="protein sequence ID" value="SGZ30249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PP91"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ30249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="491" mass="52891" checksum="4B68B42B6286B1D4" modified="2018-09-12" version="1">METGDTGPPPGAPPPPSASAATSVPIGTKETQVPIAAATYATAAIQKTKQTPEQQTQQQHRAKALTQMFEVMGAVPGNRTDRWLQATFATDEYPVATATSLKYSALNANRSIRNIFDFALDVTLTVQGASKASPADKADLLGCVTRLLSPQSPLCFDAEVTLPEHLAAFAPQIRGIQHSSFVRAGVVNHRISVGFVSAKARDSALTAPLALTWHSAKAHFAKAHHFYHNMVELRINVGVAAVPSRDAIVDSFKSIVTKITAKGHRCELVQVLRVIHVDNDSAYAHLAGEFSAFIRFDDDALFKAPNNTLKELLPSKVSLATRGNMHTAVRHDYEREAACARCHFKEANKNTGRHNKHHNNPTNTTTNNNDTTNTNNTDNDASEVAPSRALGTDQLESRNRFAGLEVEGGQEDDIEEEVAGKEGEEKEQVEEGDEDTGAKADDEDSDSDGNAGAGIDKAGGDGKDDDKDDDETTTRTNRTTARREANEGGMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PPY2</accession>
    <name>A0A2X0PPY2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C143g13439 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C143g13439</name>
        <name evidence="2" type="ORF">BQ5605_C143G13439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000140">
        <property type="protein sequence ID" value="SGZ35638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PPY2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ35638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="43" mass="4615" checksum="5AFC8F766B0E64D4" modified="2018-09-12" version="1">MKLAKGGYKATTASSWVKVKPLRAKSAAQIKTRRAPNADSNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PQ08</accession>
    <name>A0A2X0PQ08_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C042g12038 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C042g12038</name>
        <name evidence="2" type="ORF">BQ5605_C042G12038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000116">
        <property type="protein sequence ID" value="SGZ31910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PQ08"/>
    <dbReference type="STRING" id="796604.A0A2X0PQ08"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ31910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="267" mass="29047" checksum="91A4A15C4C7DA086" modified="2018-09-12" version="1">MGQFFAGKVASRRADPLSIMQAVAAAHHRSSPAKVRGVLTRPVMRLLAWRGRPPLKPPPLRTPAGSYRRSSTSASLRASSATTCAAEVVGDEDTVADELDTNHGATRPRPRSVSTNSFFTRIYHRFGSTQAQAQARAAPSPPAPPEQLLERVLSSLPRMANSASAVRLQHRSRDDVQQELYAWKRACAAAYVALDGPLRDTQSLQLHERIVKVVAHTLRLLIRTDQVHAAAELDKAFFTSSPNVVVPFPLLLNTQAARAIAGSRRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PQP4</accession>
    <name>A0A2X0PQP4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C066g12819 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">BQ5605_C111g13223 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C066g12819</name>
        <name evidence="1" type="synonym">BQ5605_C111g13223</name>
        <name evidence="2" type="ORF">BQ5605_C066G12819</name>
        <name evidence="1" type="ORF">BQ5605_C111G13223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000105">
        <property type="protein sequence ID" value="SGZ30260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000134">
        <property type="protein sequence ID" value="SGZ35276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PQP4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ30260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ35276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="147" mass="17129" checksum="A820F6C9C1D8BF47" modified="2018-09-12" version="1">MAATELQKLKELGPLRHENSAEWFRCARHFFDMTGTSLHIDFDITKPAKRGEKETEDTFYTRAQRWTKVNSQGLLVIETCVTKDTWVSIGGNTHSSFRQVWDALKKRFDRPAPGFTLEILFSEFCTFNYKPGEDLNDYLNKRRESNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LNV2</accession>
    <name>A0A2X0LNV2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BQ5605_C011g06363 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C011g06363</name>
        <name evidence="12" type="ORF">BQ5605_C011G06363</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LNV2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0229">DNA integration</keyword>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GAG-pre-integrase" evidence="11">
        <location>
            <begin position="19"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY12027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="205" mass="23040" checksum="8039DB17C33FFA2D" modified="2018-09-12" version="1">MTITYQGVILAKTLSGTGYALDFTRIVEDQAHVATRATVGAPLMEWHRRYGHVPVSSIMELVKSGAVEGLVLTDEKVHDCEPCISSKSRASKFSELATQVTDVLQRVFMDIGFVAEDQVDFQGRKAYLAIVDQYSTAKWMFLLKTKSAEEVTRVWIAFRQGVEKMTGRKIKRVRTDNGTEFTNKLIGADFQSQEWNNKQSPSTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LP82</accession>
    <name>A0A2X0LP82_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C011g06486 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C011g06486</name>
        <name evidence="25" type="ORF">BQ5605_C011G06486</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="516"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="264"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="773"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGY12370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1305" mass="145127" checksum="6E45AECC34E20BB8" modified="2018-09-12" version="1">MLQQQVMSPSETIAQESGVIKIAKLGKDSYELWSIRVEAYLESKGYASVLEHGHVRPSDISLAEWRTMHGLDASVTDTQVVVNLQKKDRSARALIIQCIDDANLKMVKSKTLSAKDIWDKLRQHHEGNAKPFKIRTLLMELSNAKYNEDENMGEFLKSMIDKADQLDDLGQKFGDEAMIAYILQALPPSYEMLKQAIRLGENRSVDHVINRLTDECTERKLSGKFDKLLKNAGALAVQSTQASRDPNCVCRGCKGKGHFAMDPECPKYDAKKNHGRARNRNKKKKQDSKESADSNELAKFALTVKSLDESHSLQDNVANRVSQVNQGEIWILDTGASQHYVGDASLLSNCQSGNLKVQTASGQVVHCDTYGMVRFKLKSGASLSLANVYHLPGAPVNLISTRALFKSGAKCGWEDGKDVVTITYQGVILAKTLSGTGYALDFTRIVEDQAHVATRATVGAPLMEWHRRYGHVPVSSIMELVKSGAVKGTVLTDEKVHDCEPCISSKSRASKFSELATQVTDALQRVFMDIGFIAEDQVDFQGRKAYLAIVDQYSTAKWTFPLKTKSAEEVTRVWITFRQGVEKMAGRKIKRVHTDNGTEFTNKLIGADFQSQSILHETSAPYTPQQNGTVERFNGLLMVIIRAVLAASKLSWKYWLYALAYTTFVANRILHAKLEGKTAYEVFYGKKPKVSHFCPFGSTLYAQVPKSNEYNYRVLVDPNSDHKVIVTRDISVLEHKSEQVGVPEVTTLPVGPDEEKGPVDNDDVVVDELQDQVDGEQMPPARQNRPRWEYGDPAVKGRNPGRYEEIDANNEIPHCTRSQRRDAEQQVMYGSAMSVSLPPVPSNYEEAMASPEADKWIAVIKAELDAMARHQVLIDSDLPSGARALGSKWVFTRKENAQGEVTRYKARLVAQGFAQRPGIDYNETFAPVARPSTILSLVGTAAAQGLFLEQFDFDSAFLNGTMTEMVYMKYPKGWDRPQTGQALQWNAAVNSLMVERGYKRSDADSCLYVKRVDEKFIYITLYVDDGMVASNDQEFLDAEIEAFNKVYKLKRLGPVKLFLGLEFKRTSDYIFVHQSKYIRNLVAMYGGGSVSKHPVKVPMEPRSDVEHSTDPFDDMALYQSAVSAPTQADWIAVKRIIRHLQGTVDWGLKFNHGGSTVFELYSDASWGDDMSTGKSIGAFVSILAGAAISWQSKQQSMVATLTMEAEILAASAAAKEAMWLRRLAADRELEQPKATLIWKDNQAVIVIALNPAHHGRTKHYSYCKTGALTADILTKPLARNLFDLHREGMGMVSLGALTSGSVVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LQ70</accession>
    <name>A0A2X0LQ70_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BQ5605_C010g05943 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C010g05943</name>
        <name evidence="12" type="ORF">BQ5605_C010G05943</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LQ70"/>
    <dbReference type="STRING" id="796604.A0A2X0LQ70"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010435">
        <property type="entry name" value="C5a/SBT2-like_Fn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051048">
        <property type="entry name" value="Peptidase_S8/S53_subtilisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43399:SF4">
        <property type="entry name" value="CELL WALL-ASSOCIATED PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43399">
        <property type="entry name" value="SUBTILISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06280">
        <property type="entry name" value="fn3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016110240" evidence="9">
        <location>
            <begin position="24"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="10">
        <location>
            <begin position="213"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="C5a peptidase/Subtilisin-like protease SBT2-like Fn3-like" evidence="11">
        <location>
            <begin position="672"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="873"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="886"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY13683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="989" mass="104468" checksum="6C2C90134FA76A01" modified="2018-09-12" version="1">MRSFVPTVILLASLAHFCSQARAFGLARAVAAGTAHSSQESDAGDGSGAPPNRYFIVAHPSPQAGRVSSNSPFDVQLVSVRALARPFTQLPKGLRGLTCTASLDGIISKMPTGVEVVHQLRSEWFQGLSVVIKGNVTAGELGATRGVKHVIPVGKIPHPEHSMPASLKTLLIRQNPIERLNKLAVGSANQSTAVFAPHAMSGVDKLHRRGVKGKGAHVCVIDTGADYKNPILGGGFGPGYKLTTGYDFVGDDGQSPSNDPYTECDKHATHILGIIGANENPYGFLGVAPEATLGLYRIFACRQQGGQDDTLVQAMLRAEADGCQVISMSFEAGNSDWGDDYPPRTVMNGLSAKGIIFVASSGNSGAAGLFSAQDPAIVSSVLSVGSVDVTAFARVFPLSFDNSSLKPVGYLSVLPIMLNDSMPLYFVSQSEKLDLNNPACSSLPASIQDLSQKITVVQLTPQCDFTSLQIHLTARNARYVIVHDIANSPTAAASFYVPGIDQGTYFLGMSKEDGLRLLSYYKSDPSLRVNFRTRMPLAPLPNRSTGGLISAYASHGPSNSLGSPGTHIVAPGGSILSTFPISMGSIGIISGTSMSTPFVAGVTALLLSCPSKKGLSSDQLRALLATTAKSVIGGSKKGDGRPASVLVQGGGLVSAPHVFDAKTLVEPYFLAMNDSSSHERTRSIRLTNHNLRAVTYVFNNLPAETLALFNENVSSDSLIPSSPPCLVKSARVSFSPTKLTVPAAGSASFQVTITSSSLYSNHFPFYSGTISIQGDDPSQQRFQVPYFGLAAKLANAPVLSTSLASSSRYGSEGLRYPFVSIGYPSSTALVLGRGQGSNVTTCKRSDGLTIVYRLLLPTRALYVDLVSANTTQHPTIPGRRLPASPTRLSGSSQQLTQDRRPFDATSTLGRIYTTDLLDRDHLPTNDRQISFNGGIPPATLDSLGAGSQPKQLATGQPARILLRALRLNADPGLESSYNSFLSAAFQFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LRD0</accession>
    <name>A0A2X0LRD0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C013g07282 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C013g07282</name>
        <name evidence="3" type="ORF">BQ5605_C013G07282</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LRD0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014144">
        <property type="entry name" value="LigD_PE_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39465:SF1">
        <property type="entry name" value="DNA LIGASE D 3'-PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39465">
        <property type="entry name" value="DNA LIGASE D, 3'-PHOSPHOESTERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13298">
        <property type="entry name" value="LigD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA ligase D 3'-phosphoesterase" evidence="2">
        <location>
            <begin position="152"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY15187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="427" mass="48511" checksum="25F661C5730EAC0A" modified="2018-09-12" version="1">MADDIFRITRPGVADLSQWQQQERKAATRRLANKGDDDVIAGTPNTAGAGSATISHPDRINETDPFGRAASRMKRALPSRTQSSSSDRTADVQAHEDDPRHAKVPRKEAPNKSIRRRYTAQDYYAWHASEAHIQTYFSHHPCLSQRNFYVIQNHHATAKHYDLRLHLDGGTLSWAIPKGLSDWDPSTGTEHRLAIETYPHTLDYTLYEGSRVGTTAVWDLGTYKVLPTFKKQRLKTKLNKEGFDLDHDTSEDEDDDDDDLINQANLDVADPTAEDYLEEDKLSRKYHYAAFLPTPARYDQDAKPAQRDVEGSHRGFVLELRGKRYRGLRIRFHRTAKDIKHITFPKAYARANPTDPRAQPGAPLEVQRRWMIDLVTQGYEDRSIGHVSLLTGRSIEQIKAATESEQNTSGDTAQSEEEELWRIGILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LRM8</accession>
    <name>A0A2X0LRM8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C013g07392 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C013g07392</name>
        <name evidence="3" type="ORF">BQ5605_C013G07392</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LRM8"/>
    <dbReference type="STRING" id="796604.A0A2X0LRM8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="19"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY15523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="698" mass="79663" checksum="AE15E77857E47B0A" modified="2018-09-12" version="1">MTASLAEGLVRLLPKNKPGANLKSLGAYRPITLRETTYKVLSKVLVARLNGVLGELLPPAQHGFMPSRRSADAGIFPEGALLSLDQQSAYDRVDHAWIFDVFEAFGFGERFISLLRALYDPETLGVRYLINGFPTELVRLLCGLGQGDPSRARFGTSRSSPSSTPSFGAGSRSTCRRCGQGGRVRSLRIWRLPTMLWWWWSHRRHCRSWKRLSQTWYEATNGKTNTDKTLVLPLGPNWLRDETAQALPTVQEGESFKWCGYAFFRQVTRKLFWTHVLDRIKAKARAARDRTLSPSGRVFYANAHITSTVLHVLSFDIPPQWFIQAAETALTDFVWGGPRRNTVARDFVFQAREDVVAAARVTLPTIKSELLTLPELLSLPPRLPSLYAEGAKHAYDDADAVAKFAQIADLYWRDEGKGWALVGHRRGFWQHSKEPALRHEHVWARRWSEAQGESLAAQDRVRPARIPLKEDPHPRCFNFFGLTRPFTIRKLRRLVNTVQFPGKDGQDRALPGGQPQEPRVKRFPEGTSQSGRQRFWSWLHDRFASAAEQDTHWRLMYDVTPTRKKQHVQGHASSPRVSHYFFGCAYSASYWSGVLRILFDKLGIEDTDVDPSTFTQEQLTMGLPLLRGRGRTTSKWMWVRLACAIGFQRLHLLRWHVHQRFEKDRVVAPPSIPSALRAFNRDYLSRAGFVPGARDWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LRN0</accession>
    <name>A0A2X0LRN0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C013g07295 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C013g07295</name>
        <name evidence="1" type="ORF">BQ5605_C013G07295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LRN0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY15233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="77" mass="8650" checksum="1A921EE1ACAB6536" modified="2018-09-12" version="1">MKVSTEKHDWAPRKYECCLAVVERLPYEAWSQPAKVDLLWRFCGWPSLLGGLQKRSGACAAEARSFAPRQLTSNVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LSY3</accession>
    <name>A0A2X0LSY3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">BQ5605_C015g07830 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">BQ5605_C015g07830</name>
        <name evidence="17" type="ORF">BQ5605_C015G07830</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LSY3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0229">DNA integration</keyword>
    <keyword evidence="14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="16">
        <location>
            <begin position="266"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="SGY17598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="488" mass="53344" checksum="9D4898DC7859B541" modified="2018-09-12" version="1">MTGEQSTIDKSVDADPSTHSQASRFPAFAILKKITTSTYGSITFASPSTGDDDELDRAHDAVHRAMHQTCSESVAHLLVSCYDMTPEQTVEYLRKHLGRSSLRGIFTQIGKLFSVGPPPAQEDDYLPWAGSITRLTTDLRAHKLTFDQVVACHLIAIVRARRPSYLDEFDSKGVDAMPTVDTVIAADRAPENLRQDTGNAATALLATTGAQPKPKKKKFSRRETTKGEEPMANLALPSVEDILGTDSVGAFFTQLPKGHSREVILYDTAATHHVINDPAAFADLKATAPSSLKGINGDGKTIMGVGTACVEDENGKRYKLVNSIFATSAPANLFAGHRADRDSRKITIQNGRFTVAGNDNILLTGQKLNSGLYRLDLKLVQARSAPLDCLNMKSRSDLKCESCLAGKATHKPFPNSESLAGKPLDLVHIGLLSFDGELSLANHRYVLVIVDDCTRYMWVLTMPRESDSFERFKTWKLRVELSSGHTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LT61</accession>
    <name>A0A2X0LT61_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C010g05848 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C010g05848</name>
        <name evidence="6" type="ORF">BQ5605_C010G05848</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LT61"/>
    <dbReference type="STRING" id="796604.A0A2X0LT61"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648:SF1">
        <property type="entry name" value="ADENOSINE 5'-MONOPHOSPHORAMIDASE HNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="HIT FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="5">
        <location>
            <begin position="48"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2 3">
        <location>
            <begin position="138"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="1">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY13380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="213" mass="23251" checksum="E35655382C6BF298" modified="2018-09-12" version="1">MASSQNATSSYPKPFPSSGHRTSSASSVLGDAGKSSEPDRIETEEGCTFCEIRDRVQRAARVYEDEHVMAFLDILPIREGHLLVVPKAHYARVSQLPSILSSHLGSVLPLLSRSLAKALKNPDFNIVSNTGYAQIVHHVHFHIVPAPNLNLNSSSSTNTSTNANRTGWASLVGREELDESEGEELARKIRECVHEELAKEKEGRGKGKGISKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LU44</accession>
    <name>A0A2X0LU44_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C011g06660 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C011g06660</name>
        <name evidence="1" type="ORF">BQ5605_C011G06660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LU44"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY12936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="54" mass="6329" checksum="816F62CDC8AC50D3" modified="2018-09-12" version="1">MECYKRLWKVFYKQEITMPDVGRWKVEEGGGVLWNEDDSRVSACCLKEEGGDRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LX70</accession>
    <name>A0A2X0LX70_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C012g07032 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C012g07032</name>
        <name evidence="5" type="ORF">BQ5605_C012G07032</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LX70"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019315">
        <property type="entry name" value="MMTA2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039207">
        <property type="entry name" value="MMTAG2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14580:SF0">
        <property type="entry name" value="MULTIPLE MYELOMA TUMOR-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14580">
        <property type="entry name" value="MULTIPLE MYELOMA TUMOR-ASSOCIATED PROTEIN 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10159">
        <property type="entry name" value="MMtag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016111464" evidence="3">
        <location>
            <begin position="26"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Multiple myeloma tumor-associated protein 2-like N-terminal" evidence="4">
        <location>
            <begin position="52"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="92"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="233"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY16930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="318" mass="37067" checksum="B813341972D5F022" modified="2018-09-12" version="1">MERLMLTPVHASCLLAVEVLGSCFASSVACAAPRGVDLEKFKLTLFIDLEPGNRGGQGDFKWSDVAADKDREHYLGHSILAPVGRWQNGRDLAWYNKDKDQTQDEIERQRRRELRKIKEAEEDALALALGYAPAVRKPSPPFGQSPSPPRDDSVDPHEKALAKEARNREKERKRLEKEARRAERAIKREERSRHEPSSHDRHRHSSHAQHQRPRENSPRHRSTDASSPRSRHRLEEEARYSNDLRRRPDSGQQGSDRNEQDRRARLAYPEDRRSNYRTHACQEPDQRHRSNERDVGRHYEHDRPPSRQRSRSPVRPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LXX6</accession>
    <name>A0A2X0LXX6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="5">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C014g07554</name>
        <name evidence="10" type="ORF">BQ5605_C014G07554</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="5"/>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY19072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003840">
        <property type="entry name" value="DNA_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02689">
        <property type="entry name" value="Herpes_Helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="8">
        <location>
            <begin position="429"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="7">
        <location>
            <begin position="1104"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="9">
        <location>
            <begin position="1404"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication helicase" evidence="6">
        <location>
            <begin position="1499"/>
            <end position="1545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY19072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1588" mass="178861" checksum="B52B134FDE943EE2" modified="2018-09-12" version="1">MPRSQGRQGLREGHRNLAKSWARVAPYHGLPWACSSARCWAPRGSTLLFVPLRSTESAPRRVMTTMQPILALRHVYEPAPHVSIRDDLGPQTAVCTHCKARHWECERSKSTRHFSACCSQGKVRLPPPPQPNLEYRQLLQGSDSEAKAFRENARSYNNALSFTSLAAHWDQTQVGTLGPPVFRVFGRLYHRLDALIPAVNQRPAFAQTWLIDPAEATDTRLQGPDSAETRIQRSTLTKLESMLRTGNRFVREFASAKARAGWDTAKEWVLRLCLPPGRDRRTHNLPTSSTEMAMLICDSDTNTGDRGPQDLILQVHGDRCPDGRPKYQIVSSLHPSAMPLRYPLLFPAGEDGFHPNIPLCGFNQAGPPIARNREQIDNGVQLRELLDGFGQMKKTKRRTMRMKATRRTKRMVMVNRGRGGSTRVSRSQYFAYHLHERDDYFSIPHATQRLCLEFMIDGYSQVETDRLNYIRLHQESLRLTTAQGITDAVANGLTPDQIGRSVILGSTFKNSPREITQRYQDAMACVVKYGKPSLFITVTCNPEWPEIKAALGPNDKACNRPDLIARVFEAKLNRLCDDVFGNKQRAGCFGVVLTHTHVIEYQKRGLPHAHILITLAPDDHPLSTEAIDKMISAEIPDPSRYPDLHETVTKHMLHGKCGGNSTQPCMEKDKYGNPRCKRHFPREQNPHTRMHPEGYPLYRRRFRHAVVKGGVIYNDGDCVPYSPYLCAKYNAHINVEAVTTIGAIKYLFKYVYKGPDRAVARVERAANGEGAREDEPVRDEINEFVEGRYISAPEAVHRLFGFSVGRVWPPVNRLPVHLENQQSVQINPNEPLPLDTPPTRSKLTGFFDLCAAAPDGELTTTLLYTNVPRYYSWNKEKLRWKRRVHDRNVIGRIYTVPLRSRERFYLRLLLEVVMGPTSFADLLMFEDVVYPSYRAACAARGLLADDGEHHICLREAAQIETGDQLRRLFVFVLIHATVANPPALLDRHFASLSDDARYHIERYEDVPVNDQTIRLWTLNKIRLLLAANDRTLVFFDLPELTEDEVRLFDRLEERLPRFDRQQCAQDAEAAHARLNHDQRIAFDECLRAVELDVVDQMRDNNLGPQHVFFLLAPGSTGKTFVENALLDTVRARGDQAIAVASSGVAALLLKGGHTAHSTFRIPLDTLPTSTCPVDRESDLALMLRTTKLIIWDEAPMAHRFAVEAVDRLLRDHRETEEHFGGVTMIFAGDFRQCLPVVPKGTPGQIVDASLIKADFWRDVRVLRLTENMRLSSNADAMDEAQLARTRDFAEWLLTVGDGTANMHPYDKIALPDYLLLPDGQRTAEGLINFVYPGLRTVNKESLEDLIQLFSRQAILAPHNATVDRINAKLLEEFNGDYIEYRSADEVVEAGKTGGGMAPELISPEYLHSINPSNFPAHHLRLKEGIPVVLLRNLDPDAGLCNGTRLIVSHARSRVIQAIILTGDRAGTTVFIPRVRLETNATGSRQLGFTMRRLQFPLRVALAMTINKAQGQSLDRVGVDLSLHPVFTHGQLYVALSRAMSVDRIKVLLPSRDPADDDDDLQAVDRAAAAATATPNPVFRAVLRAMNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LY21</accession>
    <name>A0A2X0LY21_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C002g01216 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C002g01216</name>
        <name evidence="7" type="ORF">BQ5605_C002G01216</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY31228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LY21"/>
    <dbReference type="STRING" id="796604.A0A2X0LY21"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36460">
        <property type="entry name" value="UPF0132 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G10255)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36460:SF1">
        <property type="entry name" value="UPF0132 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G10255)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY31228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="196" mass="21164" checksum="44E03DEFE7BEE4F0" modified="2018-09-12" version="1">MSSTPLNFAPYSEPPDVSKARWAPPAPSSTSSYTPQAQPPQASTSYQSGAPISSLGANTSFSSAATPGFLTRSLPGGAGGALSTGTETTLGYRYDYEGPMAYALGPFGAVGLLVLEVENDWVRFHAWQSVLLTGVLVSLHLIWAVWGLHLLASIQLLVECAVFILLTWQTYRDADLLDRYELPWIGRIANQWVEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZ02</accession>
    <name>A0A2X0LZ02_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small nuclear ribonucleoprotein G</fullName>
            <shortName evidence="9">snRNP-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C002g01513</name>
        <name evidence="11" type="ORF">BQ5605_C002G01513</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a role in pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY33589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LZ02"/>
    <dbReference type="STRING" id="796604.A0A2X0LZ02"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034719">
        <property type="term" value="C:SMN-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097526">
        <property type="term" value="C:spliceosomal tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01719">
        <property type="entry name" value="Sm_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000023">
        <property type="entry name" value="Small nuclear ribonucleoprotein G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034098">
        <property type="entry name" value="Sm_G"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF2">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="4"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY33589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="75" mass="8306" checksum="F2B9D07B17F939B6" modified="2018-09-12" version="1">MSKVSAPELKKYMDKLLVVNVQGGRKVSGYLRGYDIFLNLVLDDAREENQVDKTPCGTVVIRGNSVTSMELTASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZ81</accession>
    <name>A0A2X0LZ81_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C016g08103 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C016g08103</name>
        <name evidence="2" type="ORF">BQ5605_C016G08103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY20595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LZ81"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY20595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="125" mass="13701" checksum="88B3C07C52A2ABCB" modified="2018-09-12" version="1">MTLVDSLKDAVNSLAHPGKSTETQPLEHPAHHGASATQHLDTDTPILKKLWSPDTTLQVKANGNNGVGMEDGLRAKAIQQQENVAERSRLRKEGLFEEHMTHEGMTNLSQEHRDVADGSKVESSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZD8</accession>
    <name>A0A2X0LZD8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C002g01676 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C002g01676</name>
        <name evidence="4" type="ORF">BQ5605_C002G01676</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in endocytosis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YPP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY34748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LZD8"/>
    <dbReference type="STRING" id="796604.A0A2X0LZD8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051722">
        <property type="entry name" value="Endocytosis_PI4K-reg_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083:SF464">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT DOMAIN 7, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN, TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="617"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="617"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY34748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="933" mass="102854" checksum="B2FB5021D1D87720" modified="2018-09-12" version="1">MSSSKGSMYSITLDQARRLALWTEAHPAHSSGKVNSPAESGSGSSSDKGMDWKELLRKFTKHNPHRPITAATAQTDQLLHSLLARAAAASSYSPSTSHALDNPGQVPAWPPLVRIDDRPDILASLAALEAALRHSQGKDVERNSAAIVSAYGLYSVGEFDRAANELKQVDKGLPSAGDFEAYDLTLRVLANATEGFALERLGKDDDAIAAYTRAAKIYDDACAVLSARNSPMDDVELHVVGEAALYRLCVHSKAKSFTRSDPRVAYAHHRLYVRRATTISAAQKTPSRRAPSTELFPGSKALVIQRGFRHLMKQTGQYEAPSSGSSQEANLRSSTSLPKAGEVNKPYLIFLDEVAEGWRRNGAGRDGAAEVVEVMYNALTHTFQSHRLLRHLARALVALGQYDEAGKAVRLYFELWNKARETDAVQVAKDIRRLRGESAPRLEHDDDREDRYANDFDPDRDFVETAAWGSRLFCKYINDPKFGLELAKRAREIFDEKKDRQLAEDKVVLSKIERACGVALGALTAKEADVESRPRQHAEALRHLETAAQLNPNSWETLYHLAYQLAELRQIDPALDRARQAAALNNSSKEVWHLLGLLVAAQRDLGAALQVIETSLNDDDEDEADEAGVNGVRNGQTKSNSIENGLDRFEFSSDDTQRLQVEFSMRMTRNVVIEAMEGPEAALIDQQQLLADFSKSFAQVRDAPELKIVADALPIDTSNGAPLARRKSISLSRARSIRGSVTGNDEADFGVAPAPSVSMNPRATKVLVDIWLMSAASYRRAHKLEDSRGAIAEAEALNPNDADVWTQLALYRLAKNELKAARSCLIKALSFQADHVPAVILMARVYLADPVPSSTTRSPTPTATTNPKLPFAEALLDTLTKRYGWDVPEAWFELSKCYKGSGRTEREKECLVWALQLEETRSIRSLSAVPRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZL3</accession>
    <name>A0A2X0LZL3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C002g01693 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C002g01693</name>
        <name evidence="7" type="ORF">BQ5605_C002G01693</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY34869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LZL3"/>
    <dbReference type="STRING" id="796604.A0A2X0LZL3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028641">
        <property type="entry name" value="RCC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46207">
        <property type="entry name" value="PROTEIN RCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46207:SF1">
        <property type="entry name" value="PROTEIN RCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="6">
        <location>
            <begin position="17"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="4">
        <location>
            <begin position="35"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="258"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY34869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="286" mass="30052" checksum="056C98548EF46E27" modified="2018-09-12" version="1">MTPKSVLDLQGIKWDQIAAGGVTLFANASNDQDGEVTVSWGQNAQNGELALGVDAPRSATKPSRIEQLDGVEILDIAAGQATTLFIARPPAIKGAEVDQKADEVDTPDATEKADKVENDSTSQASKALRPVVDLSGFGFSFGPPVPVAVVTPIASALATKDTGASRTAQEKWDQIGRFPVVYDATDSCLVCGKFEGPEESLECEMVRLVVDGVRQDQALNSTLISSQCENAFHGACLSPPIKGIPEGEWFCPKCAPPGERGAGRGGKKRKAEDDDVSLPTKKVSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M0C5</accession>
    <name>A0A2X0M0C5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">serine C-palmitoyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C019g09016</name>
        <name evidence="12" type="ORF">BQ5605_C019G09016</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="5"/>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY24159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M0C5"/>
    <dbReference type="STRING" id="796604.A0A2X0M0C5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF2">
        <property type="entry name" value="SERINE PALMITOYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="11">
        <location>
            <begin position="162"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY24159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="297" mass="32804" checksum="0BE9A606F639C431" modified="2018-09-12" version="1">MSAPTSAPSNAGTTSVASTLPELIVLFNSTWATLGAWTSSIPGSQVAWRYIKASHQDDPFRTVLELLLVFFIVRTYAQSRTKGEQSGKNFVKLTEKEIDELVHEWQPEALLPPAPRTTQYPPVIIGATGPRPRVVFPTPGQDPHDPLQPYDVTTGANQGKVVLNLASSNFAGLAGNERIKDKAVACLKRYGVGSCGPPGFYGTFDVHMELERDIAAFLSVPSVIMYSHSFSTISSVIPSFSKRGDIIVADRGVNFAIQKGIQISRSNIRWYDHGDYEALERILEQIHKEDKKYKRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M0L0</accession>
    <name>A0A2X0M0L0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g02078 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C003g02078</name>
        <name evidence="1" type="ORF">BQ5605_C003G02078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY38818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M0L0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY38818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="119" mass="13500" checksum="F275C37CCB052561" modified="2018-09-12" version="1">MSIHFLVDVEEENLAGGAEMTDQEIVDLAIAEELEENHEGELEGGEEEAEIELRPVERTTLKEAISALDVFLRFAMNGYSGPTHLISFEDEARRIRRTLVAEQDAARIQTTMTSYFQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M0R0</accession>
    <name>A0A2X0M0R0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C018g08699 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C018g08699</name>
        <name evidence="9" type="ORF">BQ5605_C018G08699</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY26096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M0R0"/>
    <dbReference type="STRING" id="796604.A0A2X0M0R0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045014">
        <property type="entry name" value="TM41A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43220:SF21">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 41A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="488"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="521"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="557"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="8">
        <location>
            <begin position="406"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="634"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="64"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="634"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="646"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY26096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="692" mass="74529" checksum="0A7C4DFB5C14B72C" modified="2018-09-12" version="1">MNSHPSLSRPSRPFETMPPPSRPSSAGPIPQSTPSTWIDHLEARPSSYSVRPQLAVQTRLRARSITSTTAATNSNSTSDSGSGSPTLAPAPTPTHAGSYDGSSQGSTSTSTLASTLTSLSSSTLTVTPALTRRQTDPTGLVPLRPIASRSRLSELPLNREDTDSDEDDNEGTSVYDDAMSEGVPDLHEHEGSSSTSDSEETPSTPANDAMSPFPTWNVVSPKEQQRAFAASQVDDDVDRYTPARSKFEGSTRHDLRRGKSFTSLIVQPVMPSPAAGERPDPIAEHVQHDHDISHEEHYPPTPNDLEAGRTSFDGTTEATDAFPPSTKSLRDFVPQIATLAALFFCSFVCIALLVSSLPGLFIPHSVADLPQLTVALSAYRSMSWFAELHLFVVLATLFLWKQCFSIPGSILTNILCGALYGTTIGTFWACIWTALGSTGAYGIALVVAPLIEYYFDKPLKLTRRTLKIAPDALSKEEPAITPLSPGDLFIRLLLARFFPLLPYSVLNIISGVLRLPLPTFFVTLVLGSFPFNFATVSIGSVVALAASDPSTPLSNKIWSPEVLTKLIAVTIVSVLPVVFKKQLKEVLSSARISQLATQASAIPSMLTYIGSIYKDAIVRRVFGFGSLMPSSAMASTSGTANGNASRDWRRQQKAQEWRRKLSKPGYEEVSTMDPDGSIDDALEGGNWVPLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M166</accession>
    <name>A0A2X0M166_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C018g08627 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C018g08627</name>
        <name evidence="3" type="ORF">BQ5605_C018G08627</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY25495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M166"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="253"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY25495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="370" mass="41242" checksum="7FE3A1D1DF5BEBD6" modified="2018-09-12" version="1">MPCYTCPAYASARDAASPCTAPSAFSLLFLNAARVPSEHLPILAVMNRTSIVAGPSSSTSTSPDQRSQRGEYRDQLDELESDSEAGTDVNDAENDSDSWSIASSRSSLIVFEESMGWSDGDSLTEEDRHAAKVDQEFAKHVQDRERESQTMKNHFIKPRPEDDSRHVSWTGRLGSRRSVEEIEDAIRVATGGQSRLVVCHNENRPCAECRFEPTSEGPSLDETPDVVILPLEVVNDKDSDYVGAWSRLREGERDIRDWIQVTSVGIVQHSDSSRHARRAVPRLKRQLLRMLNTPIRDFALGFTLLGSALTIYTLTNQGLYYSPPIECTLENGNLSTFLFRLLDMSNIELGVRLSYNGRFSLEGLKEIPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M3D0</accession>
    <name>A0A2X0M3D0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C002g01621 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C002g01621</name>
        <name evidence="4" type="ORF">BQ5605_C002G01621</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY34371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M3D0"/>
    <dbReference type="STRING" id="796604.A0A2X0M3D0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF6">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="3">
        <location>
            <begin position="33"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY34371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="315" mass="34275" checksum="C44A042884E73BD3" modified="2018-09-12" version="1">MSSSATAPSTSSTSSSPNAKDQPSEMVRVPSNVVRVLMLPGYTQNATIFKGRMGAIKRSLPASVELVFAFLHQTHVVDMPTNSSADFDSSATSNSDSPETTPRCWWYAEEKEGYRHFAKMDETLEYLREFIITQGPFDGCWGFSQGKTTLGSWAEQQNISLMLITLPAGAACAAILTALVENPSLHPIFARDGPNWPPAPFKFSILSAGFMPQDPTMAKLFDKPLHTPTVHVLGRADTIVSNDRSTPLAEAFVDARVEWHEGGHHTPSKASWRHFFKHYLELFGLDGPGKEGIDSLPSPSFGTSSGTATPEGGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M4I4</accession>
    <name>A0A2X0M4I4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C001g00843 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C001g00843</name>
        <name evidence="7" type="ORF">BQ5605_C001G00843</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY49992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M4I4"/>
    <dbReference type="STRING" id="796604.A0A2X0M4I4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="entry name" value="GTP1/OBG domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="DEVELOPMENTALLY REGULATED GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702:SF31">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="Obg GTP-binding protein N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="6">
        <location>
            <begin position="77"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="5">
        <location>
            <begin position="368"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="39"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="424"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="624"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="448"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY49992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="650" mass="71638" checksum="EE73836BD97026F7" modified="2018-09-12" version="1">MVGPTTTRYLLARVYTKLPCTCSKRYELYRSYSTASNSAIDEDAHSQPPLAAEAIPGPSTPQSSTAKSDWKRRQEGSNFIDTLSVALFSGKGGPGGVSFHREKFMARGPPSGGPGGQGGSVYLVSTPTVTSLSHLPMTLRAGRGGSGGSKWLAGKNGQDVFLRVPLGTVVREVRRRENELDSLKEERDDLEMAFQVNQVRLQEAQKRTLRWDEWKKGKDRADKLGEDWHVFPEEEEVEFDPFVMAAHERVRKDLFVLYPMADLASHPSFLLAENQLLSKLLARKGGIPGRKVRRRRKRGSPVEAEAPPLYLDLKTATPLSDPILLLAGGEPGLGNPSFQAADDRSPKYATRGGDGEMMRLELEVKAGGEVGLVGMPNAGKSTLLRALTSSTPRVASYAFTTLNPHHGTCVLYSDHTFSGPRGTISDTTSLPEEFSAESPRIIKSRRSTRSEDDPPQPERIEVMRFTITDNPGLVERSAQNVGLGHAFLRHLERCRALVYVVDLAGEVEPLSALKALKVELEEYDRLKGTGLGGSVRGVVVNKADLFGGEEEGTTEGEVDEDQGLARASVEEGQRKLSEVIQWVQQLEHEMGVDKGSIWVTPVSAKKRENMKSLVKKLAETVEKEREVARLEEESEERERQEERESLIKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M4U3</accession>
    <name>A0A2X0M4U3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g02133 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g02133</name>
        <name evidence="2" type="ORF">BQ5605_C003G02133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M4U3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY39051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="249" mass="27909" checksum="0EE3E4E912D2B61D" modified="2018-09-12" version="1">MPDVVVDRTRATHGALTTNEIQKNAYIEDGRIQEKLPERDKQYGALAQRYPHFGSLDGAVTAATPLEIGSLICFGLKRGMHSLSCDQTAYYGEEALSIGIVRYIYSKVTTNHCNQDTLASLVLVVQELRLIKKTCYSTHLIDGTMPFRMIDARAHMPSKGLPPFGACPACEMPPAEPLQVAQMPPRKQGAQLQQKGSLTTKQRASQQSKEGLFEAWSHAQHQPKRRAPQATFDRPRRARKRSERVFEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M4X9</accession>
    <name>A0A2X0M4X9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C006g03749 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C006g03749</name>
        <name evidence="3" type="ORF">BQ5605_C006G03749</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY53342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0M4X9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635:SF196">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="964"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="414"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY53342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1628" mass="179186" checksum="750942F723F1F00A" modified="2018-09-12" version="1">MDNNNNTNNASHATIPPLRPDPPDPPGQAPATTTKSYSAAVGARSAAKHGNATANASTAVAAHPLMHNIENCVIINTPPSTLVEQVLLALDKYYPGLTGAMPCVIKGQRGLRFPKAADLDTLVANGLTVGKTLCKVEKLYSSTRGGVVQCTLTGFFSDPEGLCLFDEQIAAYGTVLRRRIQYIGKTKHISGVYDFILALKDVDVLPPASLSIARDGVTERIPLRITGGMRHCVFCRSAAHVHKDCPVAPACKSCASTSHATQHCPARHASSPQGPPTSRAPQASTVTTAAPAAPAAVSKSISPASAHDRTTKKRRVEQDLAAQTEDLSNRAQPDSLSKNARPEFSFNFNPWKIATPPAPQPASNQGIAYSLVEKSSKSPSSETTSPSPSPPPATPKSIITQSKSIAALSKPATREAPPTAPALEASEPSPEPSSPTPLPSAAPKARPDDADTDDEADEEADDQEAPPKDSINEDRKRASLFSNLRSHNADVFLLSKTGRPSPKRVAQWTQECQDLKLSALFTPFNNTAILWKSDSMVITFDPESPPNTLRASFSFPDRVTDATFCVGDPKVRVVSIYAPSSDKPDKKRFLSHLSTALRQVVRDEPLPPALLVGGDWNCVESQPLDSENQNGTNYGGQEMRDLATANNLFDAYRLHHPKGRATTNCSAPGTCRRLDRIYVSPDWVDLFHDHKIWAPVLKSTHSMVVARFQVPGAIDIGPGKFKLGLHVIEGDATCEYLTSIVRTLYNKALLQTPNDPPAAWTSTKHRLLPELQALARTFARFRRGGSEQERADHSRYGAALRSRLDPSLAGPSSIFIRLRKVRASDLIPSLTVNDVVHSDPDSMLGAASDYFERVYEDRPIDDAALKAIIDGLASTRLSPADSLKLEEAYPLEEMTKAQAACKSNSSPGPDGLPVEFYCATWPATGSILRDVINSIPTEARQPGPLPRNTAHIHLIHERGERDQLSNKRPILLINADERIISQAHNQRLAPLLESLIGPTQRGFVPNRWIGTNIAEVQCLMDPGLPGSTPVSGMLAVMDFEKAYDRLSHPYLDAVLCAVGLGPKARQWYRATYTNQSASIFLNGWLSATFDILSGVRQGDPLAPSLFVLAIEGFACQIRLRVKGIDIAGLQNVRELLFADDACCALHNLSDLDHLNRAIELYERASASKLSIVKSFLYPLGAFRNRSIAPDLGTWRLSDSQFRNLGIQIGVEIAEDAGWEDVKAPTIARIRSVPMYDLPYAAKCSIINIYCYTKILYYSRFLPAPKSVVKEIEEAAMLAIHGRASDGTQRRPKVSRSRLCTPLDHGGFGLIDLPRRLAIDHAKRVFQLRAPDGCFTRHLFDIRIRLQAPNEPTPFTLSRPAPNQHRCPWIWIWWAYFCHPPPKWDHAVRKTTKLLPARWVRYFEAWALVTTLNPPELSKSQNLEQWAMHVLYFPAGHGIQLSVNPTLFRGPNGEVMTSSSFVNASKRHQVFIFPPIFPKGHQKVFDLPEQRWNAWWKALRKVRRVHSDAEDTGHLLSLGSLHPGSQVASPTSPHPNNRYTSCVMCLSEAPECLVHLAVGCPFARRLWSALSPTPHPVFVDFVCPVVSRSERRLVELRVLFFHSIWKLCRRRRFSSDLLEPITETEFEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M4Z4</accession>
    <name>A0A2X0M4Z4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g02092 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g02092</name>
        <name evidence="2" type="ORF">BQ5605_C003G02092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY38862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M4Z4"/>
    <dbReference type="STRING" id="796604.A0A2X0M4Z4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY38862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="198" mass="22108" checksum="322E760ECC75F8F6" modified="2018-09-12" version="1">MTALVPPPSMDLFPTDDFYPTTSTNLYDDSEDSALDVPLHPRGGGQTELAEADEEEDDEEDGDEGGAEEEELGDDDTDEDEDAEEADEQQHDDVAGEQGGDDDDEDEDDDGDEDDEQGEGGEDDDEGEEDNEEDEGGEDEPARKRQRREPEDEEGDDDDDDEDSDEERPNFQGPPQEGYNDENENDEEDDLEDEEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M518</accession>
    <name>A0A2X0M518_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g03786 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g03786</name>
        <name evidence="2" type="ORF">BQ5605_C006G03786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY53657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M518"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY53657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="202" mass="22393" checksum="60C141132844A6A5" modified="2018-09-12" version="1">MVNSEVSLKPLLATNVPMIFTLLVSVNFMETGHCFDSCFDYWVINDVATSSTHSTPCLASCRYDQLAAFTAAIDSSDKVLGLTGFVLDIDSLPADATITLRVRRVDAPVPSGAPSASKHNLLVREKREASPSDRISGNLRPNTKPDSTDDKLINSEDHANLPTYSERRTTMMDLMLEAYPQEIVLDPWRPNHQQLCHFANCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M6K5</accession>
    <name>A0A2X0M6K5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g04299 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g04299</name>
        <name evidence="2" type="ORF">BQ5605_C006G04299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY57701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M6K5"/>
    <dbReference type="STRING" id="796604.A0A2X0M6K5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY57701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1221" mass="136853" checksum="02756DEB2D06F3B1" modified="2018-09-12" version="1">MAGNTTSRPCPCSWCKGASASKATFYRHHARQPNGPRATEEAAILEVPRQPSMLLAPPGPQSQLFQPPRPTPSWFATRSPQKYTQSAERIVSRKAFVGSSMGAQLNDSALSNDTQAYGSVSSNISHTDAPNSPSLPYESEEFSMNISPELPQIPEGDYDFERASWTGGSMDSFEGHALESDQDVLRQTQLFEMTSALETTSPALQPLDNYSSSSLPFDDDDPLVVEELWGADQRLDANGVYNIPTTSRLSSSQERAVAEEEVRQEIELAKALPYYDVDTLYDFSFRHMYNMTRQASKIWEVLGSRPSLQKFVDLGLKPVRIPCCVKTCVAFTGPREALTRCPVCNSPKLHQNGHPQNTSLYLSPDVYLNIYLRDRVYASLMRYRSDFERNRDPQEVVDLFDGDRYREKLDQNISWTNPPIAGASQPTVSTINVKYYENDVDVAFGLFTDGIQLFNKTQSECWPIMMINYNLPPEIRYKKKHLMTVGIIPGPKGPKDIDSFLHPLYEDARASARNGHMVFNGVTETMVRQRWFIHVIGGDGPALSKMLGFKGPTAKWPCRVCLIQGVPCAAAHNHNYYPLKMPLDSSHANRSDLTALDLPMRSEATIREAASEKNPTFGLSKLSSAAHLPGFSLHQDGPSDFMHAVFENVARKLFNMWHGDLAAQKSKGYKTQAPQAQRGRSAQGKVTSAASAEATTSAAAVDEALGTDLPDWVIPNKIWEVIVQEITNGAKTIPSLFARKMPNIHLQTGAMTAEDWSNWILYVGPCVLHDRLPAKYFAHFLALRRWVKDCMAMTINKEDVAKDGALRRDKASWCTEFESHLTLICLVYLGFRLYYSGKSAHLINLPHSVHAVLHIADFIKWHGPPAMTWCFAMERLNQTVKRVASKAHRLPYEAVNRYVCADAALQMARSRFPRFSYPITVPALMKHQQDNQMELEQMQQSRGFFMNATGDQMRGSSAAASRQASSENGDSGAEALGLYGRRSDKLKQGPGINDVIRVAQFIARELFGQLAPVVFKRKVDAIRTSILSLSINSFEGYRMDSGRDRIAAAERLSKHARVSADTRDASWISYDLLIDSSRRRARDNFQAFPREGEGADRVKHFGQLLAIYEFRYGEQNFLLGKVRSLGLSHLQPVDTVERAPIAKPTPKRQKRKALSVVGGHKHQNLFFTQGKRASGAVEIVDLRCILGSAGRIHRRVGREESREYIFDRMDDEARPNFLNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M7F4</accession>
    <name>A0A2X0M7F4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C007g04570 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C007g04570</name>
        <name evidence="2" type="ORF">BQ5605_C007G04570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY61559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M7F4"/>
    <dbReference type="STRING" id="796604.A0A2X0M7F4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013745">
        <property type="entry name" value="Bit61/PRR5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32428">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT BIT61-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32428:SF2">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT BIT61-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08539">
        <property type="entry name" value="HbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="413"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="620"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY61559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="648" mass="69376" checksum="8B50680E43733A5B" modified="2018-09-12" version="1">MDADHHPSTSWQDDSPTIRARSRASSMTTLGGLRRAAADAAAAAPTRPSTTAGAFGGQLQPQIQLSRASSVNRSSSGKATPLLHSGQASPAPSTRSSWIRSSHHSSGATQAGTPGPGILSKSPTLTSPSPSGTPTPSASASVTPSLTSLPTLKALESYNVRNVAAALDHSTPDALRHIDDAWQSLCVRVLPLFNGEGIRGHVEDLNDLVISRIQRTFARTSSRPTASHTPSSNLSTLVTGLLVEDLTDLLTTGFLTLSSKLSPPNAPLPDDKFLHRLDETWAFFWSGLLPNLEAIFWPLRCDERLKAAVGGDGFDRLQGGRTRQGEGRIDIRKFAIISFRDQVILPEEPRLMTLFQNGSPTNDDDEAEQQLPSARRRRQEGEDGPDAPSESRQSRSGAKPAYVSNGRSVTFATSSPLSSPSSSIITPRRRQLFSVLASVLTADDRQLMVETLLKSLRSNRPDRRRSPLSQHRVDDDDEGHRPPFFNHSSSASTMNRNNTSGRKSGFLGSVYSDGHRSNRRNGGGAGSQRPLSREEGDGGDTPFSDQTSDYYFDSPGVPPSPVIRGSEETRSGSTPISANERIDDRTITSRRGGGGAPNPRGSVLPSPSTSSLNEFGQSVTQSLSQSDQTGTTGGTIRAFPRAAIPPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M8F0</accession>
    <name>A0A2X0M8F0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C004g02633 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C004g02633</name>
        <name evidence="3" type="ORF">BQ5605_C004G02633</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY66149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M8F0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38848">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38848:SF3">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY66149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="375" mass="41691" checksum="F6DD491664832002" modified="2018-09-12" version="1">MPVQARQVSVITLCLSLFYMLATTLLATLLSLRALSGDRAARRWPLFKVLSCLSIFMAYLFVLAEAIMVIGLESDTSFLQVCAIGTYVGIGLYTVFKLVFYVFLMERVHLVYGYKTNVPIRRLEAPWYWFSLTVVAAWTVVSLSMLIARMVHAKRLEEICFTTIKSYASIVLLVVNIVVCTVLTAAFALPVVRSRFSKSQRLALTSCIATALGTLASVTNLLWMMHAEGPERAWSRGISSSMDVFFNAVLAFAITTAPGRKAGRTIRKQVEVDISKMDRHDMCPPSSLHSLHGVMITRQTSQLRDDEEPQEGDEPESGKVPDVGWLDRVFPDQHGAKLKDSSGLGTRSDSFLSENEYKAPSSRPKTAPDRMATRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M8Z1</accession>
    <name>A0A2X0M8Z1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,3-beta-glucan synthase</fullName>
            <ecNumber evidence="3">2.4.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C004g02823</name>
        <name evidence="13" type="ORF">BQ5605_C004G02823</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[(1-&gt;3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-beta-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21476"/>
            <dbReference type="Rhea" id="RHEA-COMP:11146"/>
            <dbReference type="Rhea" id="RHEA-COMP:14303"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37671"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.34"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 48 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.34" evidence="3"/>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY67900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0M8Z1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000148">
        <property type="term" value="C:1,3-beta-D-glucan synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003843">
        <property type="term" value="F:1,3-beta-D-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006075">
        <property type="term" value="P:(1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051278">
        <property type="term" value="P:fungal-type cell wall polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026899">
        <property type="entry name" value="FKS1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056261">
        <property type="entry name" value="FKS1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003440">
        <property type="entry name" value="Glyco_trans_48_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741:SF48">
        <property type="entry name" value="1,3-BETA-GLUCAN SYNTHASE COMPONENT FKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741">
        <property type="entry name" value="LYST-INTERACTING PROTEIN LIP5 DOPAMINE RESPONSIVE PROTEIN DRG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14288">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23605">
        <property type="entry name" value="FKS1_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02364">
        <property type="entry name" value="Glucan_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01205">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="472"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="514"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="546"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="601"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="653"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1276"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1325"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1431"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1536"/>
            <end position="1553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1565"/>
            <end position="1591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1603"/>
            <end position="1629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1636"/>
            <end position="1656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1714"/>
            <end position="1740"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1761"/>
            <end position="1786"/>
        </location>
    </feature>
    <feature type="domain" description="1,3-beta-glucan synthase component FKS1-like" evidence="12">
        <location>
            <begin position="285"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGY67900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1801" mass="203509" checksum="FAAF5FB66099737E" modified="2018-09-12" version="1">MSYNQTPHHLAGAPNPFASTGHAGGGGGGATGPRYAAPGDRDPYEMGGDASSGSEEYHRRAGDPYGAGSAEDEHHAGSAEYYNDKIPFAHTPMTDDEGRGGPQSHPQGPFQGPYDRSGADSPASFTDYDSSSAHHGPWSRHREPYPAWSNEQKIPLSKEEIEDVFIDLTNKFGFQRDSMRNMYDHLMIQLDSRASRMSPNQALLTLHADYIGGEHANYRKWYFAAQLDLDDAIGQANAHGPVGRLTRRASRKAGVSKGPATPPSVQTLDSAQTRWRTAMAQMSSYDRVRQLALYLLCWGEAAQVRFVPECLCFIFKCADDYYRSPECQNRSEPVPEGLYLRAVVRPLYRFIRDQGYEVINGAFLRREKDHEDIIGYDDVNQLFWYPEGIARIVLNDRTCLVDVPASQRFMKFDKIDWGRAFIKTYYERRSFLHLLVNFNRIWVLHISVFWFYTASTATKIYAPAGANDAYPAMRWSVTALGGGVASLIMMAATLAELSYVPTTWNNTSHLVTRFLFLCVCLGITSGPTIYIAFFDQTSQTSKIIGMVQFALSLICVIVFAIVPSGRLFGDRVAGKNRKYLANQTFTASYPKLSRQARLTSIALWVLVFGCKLTESYFFLALSFENPVRVLVGMKVQLCSDKIFGSALCRNQPAFALAIMFCMDLCLFFLDTFLWYVIWNTGESLFSVARSFHLGLSIWTPWKEIFERLPKRIYSKVLATSEMEVKYKPKVLVSQIWNAIVISMYREHLLSIDHVQRLLYHQVPSEVDGKRVLRAPLFFISQDGSGVKSEFFPAGSEAARRISFFAQSLSTAIPEPLGVDTMPTFTVLTPHYSEKILLSLREIIREEDQNTRVTLLEYLKQLHPIEWDNFVRDTKILAEESADIDLADEKSNKKTDDIPFYTIGFKSAAPEYTLRTRIWASLRAQTLYRTVSGFMNYNKAIKLLYRVENPDVVQVLGGNTERLERELERMARRKFRFVVSMQRYSKFSKEELENTEFLLRAYPDLQIAYLDEERPRKEGGEPRIFSSLIDGHSEILPDGKRRPKFRIELPGNPILGDGKSDNQNHAIVFYRGEYLQLIDANQDNYLEECLKVRNILGEFEDYHISSRNPYTAEGADDFADDPVAIVGAREYIFSENIGILGDVAAGKEQTFGTLAARSMAYIGGKLHYGHPDFLNAIFMTTRGGVSKAQKGLHLNEDIYAGMTAFGRGGRIKHTEYYQCGKGRDLGFGTILNFQTKIGSGMGEQMLSREYYYLGTQLPMDRFLTFYYGHPGFHINNILVILSVQLFMFALVFLGTMNKQLTVCQYNAAGQFISAAGCYNIVPTFDWIKRCVISIFIVFFIAFLPLFLQELTGHGVLAAITRLGKQFISLSPVFEVFGTQISSHSILSNLTYGGARYIATGRGFATTRVSFAILYSRFAGPSVYLGLRTLMMLLYITLTVWLWHLLYFWISILALCIAPFLFNPHQFSFGDFIIDYREYLRWMSRGNSRAHANSWIGYCRLSRTKITGFKKKRLGHPSEKLTADVPRVSWKVILVNEVFAPLALAVILTIAYLFVKSFSDPPINALLRVAVIAIGPVAWNAVLLLVLFLSALLAGPVLGSCCGNFGSVMAGIAHIGSVVSYVAFFEFLWLLERWDVSHAVLGIIATVAIQRCLFKILISVCISREFKHDETNRAFWTGRWFGRGLGSSAWSQPFREYMVKIIELSLFAADFLSGHLLLFLLVLPCLIPGMDTLHSTALFWLRPSKQIRSPIFSFKQRALRKTIVAKYSVLFGLVFAFFTCLIVLPIIFKNKINLKNCAVCDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M956</accession>
    <name>A0A2X0M956_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C011g06231 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">BQ5605_C032g11123 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">BQ5605_C096g13094 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C096g13094</name>
        <name evidence="3" type="synonym">BQ5605_C011g06231</name>
        <name evidence="4" type="synonym">BQ5605_C032g11123</name>
        <name evidence="3" type="ORF">BQ5605_C011G06231</name>
        <name evidence="4" type="ORF">BQ5605_C032G11123</name>
        <name evidence="2" type="ORF">BQ5605_C096G13094</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000010">
        <property type="protein sequence ID" value="SGY11640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY11673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000067">
        <property type="protein sequence ID" value="SGZ05287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M956"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY11640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY11673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ05287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="417" mass="47585" checksum="FE54F5C3FFB8542A" modified="2018-09-12" version="1">MSSLSAPSNASDFAAPTPASVQSTNSADMGSVLSPITVQTQQNHLPAPSGATSECGRSTPLASRPTSSNSIDQQIKQFRKRFELSMMPFRHVLYGLQRRLETMKYCLHHGVRDDDLDAYMSRAIRRNVTNDWNAFKTSRFFHCLVEKDGLEGERGVCLSSSSRDRSFWHCKTLLYASLTHKLITLYPYKVSKDFSTLNTIGLRYWEKVKDSPDLYEQWKEAWASEAEAREHEQTTRPFKRWRINPAAITKPSHKYEKTIHELVNQHADTYGFDALVIVGSNKLGNKNDRFIVSTLGGAAFMRRQSWGSRKNDVLVNFTECINGTRFNQERDEQFKMEAHHGDVDKASHRVLCTWYRIIIKDYYKTSLFSPTCLPSLRATTRKLLRRIQPLLLSSSETVFTSVISAVLPTARSRPLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M9W9</accession>
    <name>A0A2X0M9W9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C011g06485 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C011g06485</name>
        <name evidence="1" type="ORF">BQ5605_C011G06485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M9W9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY12368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="141" mass="15417" checksum="8EC4A85A15A6BBEF" modified="2018-09-12" version="1">MMKDYSCLRTLLPMGMFGTGDLMVSSKRQGPYGLPDPPSGASSPLLCTVVLSQRAGLLLSTHSRPWADWLAPVPIRICLDTINTIIQMHFIAQPGLGQPLSLGYLLAISTKVSNIEQAVDTLYWPRQNEALAVIGRSHDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MB37</accession>
    <name>A0A2X0MB37_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C005g03625 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C005g03625</name>
        <name evidence="2" type="ORF">BQ5605_C005G03625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MB37"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053203">
        <property type="entry name" value="Cisplatin_resist-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022024">
        <property type="entry name" value="DUF3602"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693:SF1">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12223">
        <property type="entry name" value="DUF3602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY77394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="340" mass="36256" checksum="54F5B27A535EBD60" modified="2018-09-12" version="1">MATLERPQLATQDSLATDATSPSDSAVPTPFPQEALIRPTPAAATRQESRSPSVTRRQSLSRGVSGMMDKVKRVMSASRDRGTSGGSGGERDRGRTGGRLAEGAFYDMSQTCEPITDDSFYWSSFSRGTCDATCIWIPNHAASTCDLVTPFSKRLSSSPGTAEEPRGRAGAETYAAASLNKAATNTTIGTNGLSQTTSRSTSRGRTPALAVGRGGAGNMKFAMQDGEAPVLSTGEEPASVVHQARVERSSSREREGRPEVVASGRGGQGNMRSQSRGKDLDLARVSTVAEVEEKAEMEKEEAKEREVLQKHEKEVAKKRVWATGRGGAGNIRSPDRSDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MBA0</accession>
    <name>A0A2X0MBA0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C007g04826 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C007g04826</name>
        <name evidence="1" type="ORF">BQ5605_C007G04826</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY63748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MBA0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY63748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="52" mass="5235" checksum="A3C2B98D64278B0C" modified="2018-09-12" version="1">MNGSTSGSTDDLFSLAMNSDTTSSFGAATAGDAPLLVQQHIERAVGFAPDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MBA6</accession>
    <name>A0A2X0MBA6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C005g03572 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C005g03572</name>
        <name evidence="1" type="ORF">BQ5605_C005G03572</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MBA6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY77174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="61" mass="6415" checksum="73BB4DC7CC200E4D" modified="2018-09-12" version="1">MFLTGAHKLLSFGLAGTATKRAKGGYKATTASSWVKVKPLRAKSAAQIKARRAPNADSNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MBI8</accession>
    <name>A0A2X0MBI8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BQ5605_C004g02599 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C004g02599</name>
        <name evidence="12" type="ORF">BQ5605_C004G02599</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY65823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MBI8"/>
    <dbReference type="STRING" id="796604.A0A2X0MBI8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF1">
        <property type="entry name" value="MITOCHONDRIAL THIAMINE PYROPHOSPHATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="135"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="225"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="38"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY65823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="357" mass="38438" checksum="4A5545B5F025E8E3" modified="2018-09-12" version="1">MSNQLSPFGMAFAGAVGGVVANSIVIKTRIQTEVQAKKSEAGAAGASSPSALNRPGAPNRLPAASTSRSAGGAAIKAKGAREMLFKILKEGGVRALYRGFGASMLNTFSMQFAYFYWYTIVRRTYMKRFPSVAALNTTTELALGALAAAFAQLFTIPVSVIATRQQTSTKDQGFAATTRDILADDGITGLWRGLRPSLVLVVNPSITYGAFERLKTALLKPGEKMTPGKAFYVGALSKTLATVVTYPYIMAKTRLQAKYEDVDEPLLNEEASIGLPSKSTQHKKRKERYNGAVDCLRQVYKENGFAGWYQGMQAQITKAVLSQALLFGIKDAIEAYVALALLWYARKSGLAVGVKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MCG4</accession>
    <name>A0A2X0MCG4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C004g02617</name>
        <name evidence="7" type="ORF">BQ5605_C004G02617</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY66050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MCG4"/>
    <dbReference type="STRING" id="796604.A0A2X0MCG4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046912">
        <property type="term" value="F:acyltransferase activity, acyl groups converted into alkyl on transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032787">
        <property type="term" value="P:monocarboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000002">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.580.10:FF:000005">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42871">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42871:SF1">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY66050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="498" mass="55855" checksum="E63169B244FA0E66" modified="2018-09-12" version="1">MGKSAPAPESSNSLTITGKSSRRGSRYNRTGKTIHVPIQHNAIPATAFKQLSKKELSNGEREEDEIENGIRVYDPGFMNTAVIESTITFIDGEKGILRYRGYPIEQLAEKSNYLECSYLLIYGELPSKRQFRIFESEILGHTYTHRDLDQIISAFRYDAHPMSILISGIASLGAFAPEANPSLAGQKLYTSGTMSSLMTMDKQIFRLLGKAPTLAAMAYRMRQGRPFNQPPAGLGYTETFLYLLDHLNEREFRPHPVLAKALDTLFLLHADHELNASAATTLQVGSTLVDPYSAVASGCAALYGPLHGGANEAVIRMLMAIGTPDKVKPYLEKVKKKEVVLSGFGHRIYRTSDPRSLIIRKTAEQVFAVTGKNKLLETAIALHDAAIKDEYFVKRRLYPNVDFWSGLIYQAMGFPMDYFPILFAVPRIAGWLAHWRQMMLQAGGVKIWRPRQVYLGEGSRPYVPMLERKEVKPKHASGEPTEVEHIFSKRNLLSREKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MCS0</accession>
    <name>A0A2X0MCS0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C004g02727 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C004g02727</name>
        <name evidence="5" type="ORF">BQ5605_C004G02727</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. ARD1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY66942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MCS0"/>
    <dbReference type="STRING" id="796604.A0A2X0MCS0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990190">
        <property type="term" value="F:protein-N-terminal-glutamate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000037">
        <property type="entry name" value="N-alpha-acetyltransferase daf-31-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045047">
        <property type="entry name" value="Ard1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091:SF4">
        <property type="entry name" value="N-TERMINAL AMINO-ACID N(ALPHA)-ACETYLTRANSFERASE NATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY66942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="151" mass="17382" checksum="340F0159D17AEBE9" modified="2018-09-12" version="1">MNVRRATVADLMEMQNANLHNLPENYQMKYYLYHALTWPQVSFVAEDHKGRIVGYILAKMDEEATTDPHGHVTSISVLRNYRRLGLANKLMQLSQQAMKSTFNASYISLHVRKTNRAALGLYRDTLGFEIVEIESSYYADGEDAYSMRLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MCX7</accession>
    <name>A0A2X0MCX7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C009g05427 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C009g05427</name>
        <name evidence="3" type="ORF">BQ5605_C009G05427</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY80977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MCX7"/>
    <dbReference type="STRING" id="796604.A0A2X0MCX7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="381"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY80977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="744" mass="81305" checksum="C1712E621F0C8754" modified="2018-09-12" version="1">MAGAQSGDKCVDVGGPEPASPPAHPARDVAQQHSGSPPSTTSSPASRRSRGSTKATTAPSTGSPKGSFTESPTTSPAGSAISSPAGSAITSPAGSAITSPTGSPITSPKVPPRVPSPPLARSFTAQLPWVLRTWMFPSSSEDRTGFQGHEIEWSSLRDFFLSPSPSRDGTAADLGQTESTMNQSLAPRITWQLGDPNLEPQGRLVKTPLRQDREAYDPNEFPDFVVLSRQAFDGNSELASAWAQDHVDAEEDDFRNWEQVAAIGVLGSKKICQDPTLDSAWVYPATRVKHHLRKLAAESPIRSHTFGFTLDGSILTLYLHTPSGLFYSSDIECTESNGHLSTFITRLLSLNDLDLGKIASPGEPDGPPLPFPVAALPPRVPVFAHHLGDGSTIDSVEIAQTVFCSGAVLGLQTSASRVRATRMGVNGEQEYAMTVSFVEEARCDEHDRIRLLIASASPQEREGLTNFVDVHREVNFGLVPHFLKGQSDADSAALKPRAMEVAFQERCFETIWTVDSTEALIRVALGVVKGLRSLHRMRILHRDVSSGNIMVGPDGEGVLIDYDLAVLMDGPFGDAARLERVGTFAFRARQLIDNVGTILHQPWHDIESLVYVILFVVFMQPTGPESRGRMSEEAAAVWKDWNWEECAYKIKVGYVQHKSNRRELLKPYLDFWDGLPDLIDIVAKYCGLNLSTYMYNGVEVEEYLKSEWGSGELSYDQLVADLEKLLEEIVQTRRERASVSPIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MDE1</accession>
    <name>A0A2X0MDE1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C009g05434 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C009g05434</name>
        <name evidence="2" type="ORF">BQ5605_C009G05434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY80999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MDE1"/>
    <dbReference type="STRING" id="796604.A0A2X0MDE1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY80999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="150" mass="17036" checksum="BE72454976AD29A5" modified="2018-09-12" version="1">MSSDATTMDSVVPSTATLNENENETSSLDSQLASLRAELSQGQLVAEATIHDLDNALQLARLEVERFKVEVHEGGKREEQLQQEVHQLRKAMEEGRKREGEDEQRQEERRKQAEQGERVKRELLEAVEREAAEKQELAGQSRRDGILTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MDP8</accession>
    <name>A0A2X0MDP8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C004g02918 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C004g02918</name>
        <name evidence="2" type="ORF">BQ5605_C004G02918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY68767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MDP8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015903772" evidence="1">
        <location>
            <begin position="18"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY68767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="81" mass="8393" checksum="D5C64B11A0F9A22B" modified="2018-09-12" version="1">MKCSLIVFVALASSAFAAPRAQPQLSNVIAGIKEDVVQGATDSKCASLCAKYQTPSTQAYCPKVCNAAAAGWAAAQAHYKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MEG1</accession>
    <name>A0A2X0MEG1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BQ5605_C004g03148 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C004g03148</name>
        <name evidence="11" type="ORF">BQ5605_C004G03148</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY70409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF28">
        <property type="entry name" value="TRANSPOSON-ENCODED PROTEIN WITH RIBONUCLEASE H-LIKE AND RETROVIRUS ZINC FINGER-LIKE DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="10">
        <location>
            <begin position="526"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="822"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1412"/>
            <end position="1479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY70409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1479" mass="162003" checksum="06D178556B51EF9B" modified="2018-09-12" version="1">MDDTSPPLATGVHPTFPADQLAALTSLLSGLTAAASGTVTTTTSSSTTRPAFPKHARLDGPKTFANWTRQLRLCLADDIRSYVLDGIVPVDWTPSQRSARDVVARELLANSIDSAEVSAVLDAIPTADLTAPKIYSTLKSRYAPDDATRTLELFSRLWSFRPMPGTVGEFDGWIMEFKAIAQEIIDTKTTINDVLATLLLAIAHPSLKSFKASFTDEQRTQRSLPAIDSLADRMRVQLRSTNVPSTQLALLASSSSRPTRPKCLACHSPSHRVAECPVRAKHPPPGPCRSCKQNHWSFDCKKALENGKKADTANSTANSQHHVGCIATGFLARRRQLRTNSFVVDSGATSHMVSDKSLFTTYRHIAPTKIGGIAGGINAIGTGNIAFVAALGHPITLTGVLHTPGLFVNLLSVSRLCDTDDVRVAFTKHGIDIDKNGHNIAEGTRLDEGLYLLDADHSKCQHLALLSRSQSSVPLLTLHRCLGHLAPSSIQKMVAAGLLEGLGAGYSDEEVEKFVCNACLSAKGHRLPFPDSDLHSSERLGLVHSDVLSLPERSLTGKRYLVTFLDDYSRKLCAYAIGHKSEVFSVFKTWLAEVELETGATLKVLRTDNGGEYCSRAFTDFCKVRGTRQQYSIPRTPQQNGRAERVNRSIVEGILALLADAHLPKTFWEEAAAYFVYCKNLVQHSALDKATPNSVWQGGCTTASALHPFGCAAWLTVAPELCSKLDPKAVRVLFTGYDLASKAFRFYDTTTKKVTLGRNATFLDTEFPGLCGDSAEPDDDTHFASAPFADPQTTVKSWTPLYSADPLDLIGSRPQAALDPMDTQPPDFSTYREPASAEESPDELDLIGRHSRDESPDEIDFLTCHHRAFIATDDDTSDTEAIEPVKSITSDPQTWREAMSGDKREVWAKAAADEFNSMRDDFKVFTIDDRSTVPAGATIVSSKFVWKTKRNALGEITGHKARLVAQGNRQRDGIDFTETFAPVARFSSIHSLLALAATNGLHVHQADIDKAYLHGDLDHDIWMTAPRGFDLPGDKVLRLRRSIYGLKQAGRIWNRHIDASLRDLGYTATGTDHCVYSRLDDRQRPHYIALYVDDLLMISPDLAEIERVISGLEQRYGVKRLGPAEYILGIQIWRLDDGSIALSQERYIMDVLARFHFDTMTRGTTVPMTPGLLLTAIPGQATERIRSWYLQAIGSLLYISLGTRPDIAFAVSYLARFANNPGHRHWIAVKHIFRYLRATYRDELVYARGEARITGVVGYSDANWGACVDTSISTMGYVFYIAGSAVSWSSKRQSRVADSTTDAEYLALSHAGKEGIYLSQLLEELHVQPVAPAHIFTDNEAAAAVARDPVRVTGTRHIRLREHFVRDMVNRGDISLSHVGTSDMVADIFTKALGPKVFSTHCYARGLRTRHPRLGSASHSRGGGCKESTLSSTEAPRSSRAPASPPPCGGDLGARDCLSEQAPADSGARPLGRPLEVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MFL8</accession>
    <name>A0A2X0MFL8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C005g03540 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C005g03540</name>
        <name evidence="1" type="ORF">BQ5605_C005G03540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MFL8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY77006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="68" mass="7670" checksum="EDE5EF268ED60C24" modified="2018-09-12" version="1">MYLIYGRRAVTIVVSPLNALSNHQAANLNRMGKKAVVVSEETRRDDELYRQLDDPNHTIAFILIVCVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHU8</accession>
    <name>A0A2X0MHU8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C011g06377 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C011g06377</name>
        <name evidence="2" type="ORF">BQ5605_C011G06377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHU8"/>
    <dbReference type="STRING" id="796604.A0A2X0MHU8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="1">
        <location>
            <begin position="326"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY12067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="439" mass="48755" checksum="5DFCCFC07E1DF102" modified="2018-09-12" version="1">MFCPAWPLRARGVSPPPQPNLEYRQLLEGSDSDAKAFRENARSYNNALSFTSLAAHWDQTQVGTLGPPVFRVFGRLYHRLGALIPAVNQRPAFAQTWLIDPAEATDTRLQGPDSAETRIQRSTLTKLESMLRTGNRFVRQFASAKARAGWDTAKEWVLRLCLPPGRDRRTHNLPTSSTEMAMLLCDSDTNTGDPRSIRLRCLSGSHYYFLQGKMASTPTFLFAGFAKLGCQSPETESRSTMVSNRARYLPVSVLLTKAKRRTKTVTMRMKTAGDEKNGDGELSRSQFFAHYLPNATSTSQSRIAPSIPSWKNLRLTTTQGINGLTPNPIGRLMALGSTFENRPCDITQRYQDAMACVVKHGKPPLPITMTYDPEAPEIKAALGLNDKACTRPDLIAQVFEAKSGNKRHAGCFGDECRMNGFVSLLYFVGCFLNLCAEIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIL3</accession>
    <name>A0A2X0MIL3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C011g06557</name>
        <name evidence="6" type="ORF">BQ5605_C011G06557</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="4">
        <location>
            <begin position="473"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="1149"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="5">
        <location>
            <begin position="1436"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="425"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY12618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1620" mass="181343" checksum="11DD3A3A4FF31B5A" modified="2018-09-12" version="1">MNRKRVALHDIASTAELCLTREARAGVCHVMRCAGGGGPSQPRQVLGARVAPYHGLPWACSSARCWAPRGSTLLFVPLRSTESAPRRVMTTIQPILALRHVYEPAASAPGSNRAQTPQAHVSIRDDLGPQTAVCTHCKARHWECERSKSTRHFSACCSQGKVRLPPPPQPNLEYRQLLQGSDSEAVAFRENARSYNNALSFTSLAALWDQTQVGTLGPPVFRVFGRLYHRLGALIPAVNQCPAFAQTWLINPAEATDTRLEPDGADSHMQRSTLTKLESMLRTGNRFVREFASAKARAGWDTAKEWVLRLCLPPGRDRRTHNLPTSSTEMAMLICDSDTNTGDRGPQDLILQVHGDRCPDGRPKYQIVSSLHPSAMPLRYPLLFPAGEDGFRPNIPLCGFNQAGPPIARNREQIDNGVQLRELLDGLGPDEEDEEEDDEDEGDEEDEENGDGERRRSNKRGRGGSTRVSRSQYFAYHLHERDDYFSIPHVTQRLFLEFVIDGYSQVETDRLNYIRLHQESLRLTTAQGITDAVANGLTPDQIGRSVILGSTFKNSPREITQRYQDAMACVVKYGKPLLFITVTCNPEWPEIKAALGPNDKACNRPDLIARVFEAKLNRLCDDVFGNKQRAGCFGVVLTHTHVIEYQKRGLPHAHILITLAPDDHPLSTEAIDKMISAEIPDPSRYPDLHETVTKHMLHGKCGGNSTQPCMEKDKYGNPRCKRHFPREQNPHTRMHPEGYPLYRRRFRHAVVKGGVIYNDGDCVPYSPYLCAKYNAHINVEAVTTIGAIKYLFKYVYKGPDRAVARVERAANGEGAREDEPVRDEINEFVEGRYISAPEAVHRLFGFSVGRVWPPVNRLPVHLENQQSVQINPNEPLPLDTPPTRSKLTGFFDLCAAAPDGELTATLLYTNVPRYYSWNKEKLRWKRRVHDRNVIGRIYTVPLRSGERFYLRLLLEVVMGPTSFADLLMFEDVVYPSYRAACAARGLLADDGEHHICLREAAQIETGDQLRRLFVFMLIHATVANPPALLDRHFASLSDDARYHIERYEDVPINDQTIRLWTLNKIRLLLAANDRTLAFFDLPELTEDEVRLFDRLEERLPRFDRQQCAQDAEAAHARLNHDQRIAFDECLCAVELDVVDQMRDNNLGPQHVFFLLAPGGTAKTFVENALLDTVRARGDQAIAVASSGVAALLLKGGHTAHSTFRIPLDTLPTSTCPVDKESDLALMLRTTKLIIWDEAPMAHRFAVEAVDRLLRDLRETEEHFGGVTMIFAGTPGQIVDASLIKADFRRDVRVLRLTENMHLSSNADAMDEAQLARTRDFAEWLLTVGDGTANMHPYDKIALPDYLLLPDGQRTAEGLINFVYPDLRTVNKQSLEDLIQLFSRQAILAPHNVTVDRINAKLLEEFNGDYIEYRSADEVVEAGKTGGGMAPELISPEYLHSINPSNFPAHHLHLKEGIPVVLLRNLDPDAGLCNGTRLIVSHARSRVIQAIILTGDRAGTTVFIPRVRLETNATGSRQLGFTMRRLQFPLRVALAMTINKAQGQSLDCVGVHLSLHPVFTRGQLYVTLSRAMSVDRIKVLLPSRDPADDDDDLQAVDRAAAAATATPNPVFRSVLRAMNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIN2</accession>
    <name>A0A2X0MIN2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C028g10485 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C028g10485</name>
        <name evidence="6" type="ORF">BQ5605_C028G10485</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000080">
        <property type="protein sequence ID" value="SGZ12166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIN2"/>
    <dbReference type="STRING" id="796604.A0A2X0MIN2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1410.10:FF:000007">
        <property type="entry name" value="Ribosomal lysine N-methyltransferase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1420.10">
        <property type="entry name" value="Rubisco LSMT, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015353">
        <property type="entry name" value="Rubisco_LSMT_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036464">
        <property type="entry name" value="Rubisco_LSMT_subst-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF34">
        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE SETD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09273">
        <property type="entry name" value="Rubis-subs-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81822">
        <property type="entry name" value="RuBisCo LSMT C-terminal, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="5">
        <location>
            <begin position="27"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="185"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="425"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="438"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGZ12166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="472" mass="52794" checksum="E26FD294FC7063EE" modified="2018-09-12" version="1">MSNGQVSTPQEQAFVDWLKSNGATVNPSIGLTQFEGMGRGAVALQDIQPDTLLFSLPRSILLTTSTSSLSSQVPLSTLTGWTPLILSLMYEYLRTSKWKPYFDLLPASFDSLMFWSDPELEQLKGSAVLDKVGKEEAELAYAEELLPFVEEYASVLGNKEDYTLDLFHRCGSWILSRSFHVESADEDEDKPKRKHDGDDENSDSDDEEEEEREDVADVAMVPMADLLNARFGSDNARLFYEPSTLNMMSTASIPAGAQIFNTYADPPNSDLLRRYGHVDEENGADLVEIGLGLVVELVGGPQGSDLSEDEQSTRAEWLLELGIDDTFVLDKTLELPEELISTIRTLLLDQADFEKVQRKDMPPKPRLDPISAKWAVAILDRRMEEYETSIEEDETLLAQTDLIPRRRMAITVRLGEKRVLREARRQVVGAFPPDAEEEGKSKENSKADKKRKAGADKGSSSREGKKFKKSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIN8</accession>
    <name>A0A2X0MIN8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C009g05772</name>
        <name evidence="8" type="ORF">BQ5605_C009G05772</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FKBP-type PPIase family. FKBP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 6"/>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY85727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIN8"/>
    <dbReference type="STRING" id="796604.A0A2X0MIN8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050689">
        <property type="entry name" value="FKBP-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516:SF443">
        <property type="entry name" value="FK506-BINDING PROTEIN 59-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="70"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY85727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="190" mass="20325" checksum="EA23EE2EA8D83B76" modified="2018-09-12" version="1">MSLPLLRTLRLTPSTVRTFSSTTRSLGVTVATLSPGDGKTFPRTGDHGAYPFPPPGLRTILARSSRTTSDPTVKIHYTGTLLSTGKTFDSSVQRGTPFECQIGVGQVIKGWDEGVKQSNLGEKVASFIGSDPTRTYPNTNPLNPTLIRPPSQKLTCTPDYAYGSQSVGGGLIPANSTLVFEVELLGIKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIN9</accession>
    <name>A0A2X0MIN9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C039g11795 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C039g11795</name>
        <name evidence="10" type="ORF">BQ5605_C039G11795</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000060">
        <property type="protein sequence ID" value="SGY90251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MIN9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006616">
        <property type="entry name" value="DM9_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057646">
        <property type="entry name" value="WD40_WDHD1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022100">
        <property type="entry name" value="WDHD1/CFT4_beta-prop_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048591">
        <property type="entry name" value="WDHD1/CFT4_hel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932:SF10">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20946">
        <property type="entry name" value="Ctf4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11901">
        <property type="entry name" value="DM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12341">
        <property type="entry name" value="Mcl1_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24817">
        <property type="entry name" value="WD40_WDHD1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00696">
        <property type="entry name" value="DM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="249"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1 first WD40" evidence="9">
        <location>
            <begin position="252"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="381"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 second beta-propeller" evidence="7">
        <location>
            <begin position="679"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 helical bundle" evidence="8">
        <location>
            <begin position="982"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="580"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1133"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1307"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="581"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="599"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1133"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1159"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1211"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1370"/>
            <end position="1381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY90251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1477" mass="161490" checksum="1160D34D3E84199F" modified="2018-09-12" version="1">MSEAPPAYGAPPPAAGLRIPLTTLSAFPSPDLVGAAPFHDLDGSGVCVASALMENQSVHPAKVVGNGRVMVSYGGVEITHQGRYDVLPITNQMEWVPAAHGQVPKGRRAVEGGFEEDGNHLHHAVTTIQGVQVPGKTGAHLRGANFPFGGGEHVVQDGYQLLCWRSERAESSWRNLDRRVEARRREAENAELEGDASRFCYTAENESSASLLRVLRQLVRDSCQPTSLLTGDRRLLFSAMDIDPTKLVTWPHTQGVSRCAFTPNGHLLYTSGAEGYIRVFDTDPSHADEGLPPPLLIDFHEEPNFGLSCSNDFVCSANESGLVVLHRHGVITEIHSILTRCNEPVRSARFDPKGQKIAVASDELIVKVIDINDAINGIQLLPGHRKGVREATWSPDGQLLTTSGQDGQIRVWDFTSGSEPTCIQTLEGVIEPNTNPTSEYSIAVVWHPSSKYFVVPSKTREVAIYSRESWSKIGVLSPPSTEGTTAGMMSSLAFSNNGVYLATAMNDWIHVWNFTERKIVTSTQHTQGLVTDMAFQPTPTTNVLAYAHSTGQFTIWKDVIPSTMAKPTWSVAKARQMLLARSEREDRETSESVTSKVGEDDDKGDDYFGDDLDGWLDDDEGLLKKRDENGMDEDRDGGDRRMNGVISKYERAGGDRISSTRYTGASSSNSYSYIQGQPSFQPGSTPFREKRRYLAFNMLGLIHAVDRDDQNLVTIEFHDRSAQTGTHFNDSFKFTMGALGELGSAFAVKGTSDSPSLVYYKPFESWTTPQEWQYSLPQGENVIALSVGGIAPEDLNEISIAGTGTVVVATDRGYVRFFSGSGLQKYVWNLGKSVVSIAAGKDWALIVYRSGSSVPDLTYVLVDTDSFEVLQQGKMPLMQGVSLAWIGFTDEQIPTMYDSRGVFSVLDRSRRPRQARWVPVLETSAIARGENKQETYWPIGLTAQHAHVIILKGEESHPHFPTPLIQELDLQLPLLRLDVQQGQLEEKYLRETTFVSHRRDGASADDYDLTTTLARQELEVDKHLLMVIQTACKAERLEQALDATLLLSQKASLIAAAKIARFFNLPGLEERIQIVQEVKEAEGDGAPSKVREGKWSHLIDERNVRAPDGFGGRSNDRNINVFAMGSKGLMMAPSSSMGMASVAPSYRDSSMGRRPIDSQYDESLSEPVGEDDEEMMDDLRASKRARSPEGSGDDEDLYESPVAETIEAVPAHKKKASNPFRRRTPPPASARTPVSPANPFASKKTGASEAADLHRTGSFFSRVEGTEAPKVKVKRAAPVAGSSNVKIQTVPGTKQTTLFGFATVVEEGNKASAPKGKKRKSTNAVTTREDGDADNDDADLPTPFAKPLPKLVPSTAGLGGHAQELPREGDEFEETQVETQEESLQPINKARSSAPKASPIDDAEVEMEATQLEEPQILSVLSTCTKENVAAVTVPMTTASKLSKYRMAAPIAPASVDVEPMMEPIEQSTVEEATAME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIR2</accession>
    <name>A0A2X0MIR2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C028g10515 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C028g10515</name>
        <name evidence="1" type="ORF">BQ5605_C028G10515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000080">
        <property type="protein sequence ID" value="SGZ12602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIR2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ12602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="88" mass="9767" checksum="016F2924F16586C5" modified="2018-09-12" version="1">MSIHFLVDVEEENLAGGAEMTDQEILDLVIAEELEENCEGELEGGEEEAEIELRPAERTTLKEAISALDVFLRFAMNGYPGPTHLISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJV3</accession>
    <name>A0A2X0MJV3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C010g06134 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C010g06134</name>
        <name evidence="5" type="ORF">BQ5605_C010G06134</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJV3"/>
    <dbReference type="STRING" id="796604.A0A2X0MJV3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22453">
        <property type="entry name" value="KH-I_MUG60_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056553">
        <property type="entry name" value="KH_Mug60-KHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627:SF76">
        <property type="entry name" value="KH DOMAIN-CONTAINING PROTEIN YLL032C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627">
        <property type="entry name" value="SCP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24563">
        <property type="entry name" value="KH_Mug60-KHD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="355"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="586"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="655"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="738"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="44"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="977"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="981"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1010"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1027"/>
            <end position="1036"/>
        </location>
    </feature>
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        <location>
            <begin position="1037"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1058"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1087"/>
            <end position="1113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY14303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1159" mass="126766" checksum="7C2560BA5ABF3F0D" modified="2018-09-12" version="1">MQRVRLRAVDWSEATPSNLQDIYTTCFNLPQQGLHHQAQAQVLSHSPSTSFNTDLNHHTGGPQVRAQLPTSSNNTNAAPHRRTVSSVVQRSPLLSEDRPGGPLPTNSQPSLSKSSSSHNPRTSLSSSSDGTAAESTSSEGGGGPSMRRSSTAASSILTETTATNEPFGTSCDDSSSVRLVRSASSSSALSMTRANSTDLNEAMQKLCVDAMSANQCLVSFTPLDDPSWPALAALADPTNAAIRKYNFHVSGDYQHVMSARGNLLRYSPFKRKSIVKVPRSEVLDGKENVKTEMRRRLDEIASLTRAHLAIVGHAANSIGFGLEAERNVEIVITGTFESVEHARVKLLVLLDELGGLHHEICEIDYKLHNIIAGRRRCVIQQIQEETATNIYLPTSLSGVIGQRVPSLLMKQNVVHITGEFFGVQRARDLLFQISIHKSKCVISRDTAILPRKVDWMLSARLDDLKQIMHDNGTFINFPPIGSQASMISVYGDHRVHIERTIRAIMGLACEFYVASFWLLPISIDAFMAPPALNPAQIQPFLRHIAVVSGAEVVFKSNCFEFHGLESEVRAAVQIVLDSDVVKQFHHEVRFQIELANEHREFISGKKNGKLNKIMKSANVKIKFETFNDYNFLIDIAGHDVSALHGLTMLQEELPAEISFHVPEAYHKRIIGVGGKNIQRIMKKYGVYVKFSNADEFALLGGYADNEDNVIARTPAKNALNLEHLKQAVMELLPPKDKDFCLETVAIPRRYHRTLLGEKSIFIHDIETKTNSTVRFPNKETASDVVSIFGPEAQIHIAAKMILEHVPFEAEYRIPHSAEMAALTLSQDFIRLTEHIKRNFNVAIMPWVDRSGASDETIIRFYLNRSNIEVLPAARDLVEEYLVQRKIQLYPGSLRPRPDAFNDSFSFFNSNLLATSSSDAVRDLGSTVDHKLRLAASSPNIKSIFEAPSTATYGAPGQSPLRNAASFVYRSANQDYPGFYPPTSSLQTNTESAFPTSQSQGQGMPPPPGSNPSSFSSTTSHRGWGALSRTSPFASSNSTFGGPSSAFSGSGFPKSSASRFAQTEGATSSAVPVARHHPSPSDVGPKISHGPSASASGGFGAIASGSSHASARSGLGHHRPRGLAQSFDLGLHGPLRKERGFHQSHEFVDEVESAFSSLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJV6</accession>
    <name>A0A2X0MJV6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C032g11021 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C032g11021</name>
        <name evidence="25" type="ORF">BQ5605_C032G11021</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000067">
        <property type="protein sequence ID" value="SGZ03791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="534"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="1485"/>
            <end position="1659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="774"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="877"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="783"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGZ03791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1779" mass="194580" checksum="BBCF0F8D33420928" modified="2018-09-12" version="1">MRQSPLMSGEVGCRTEVVRGKLRNRKGARTGIGPAAGELARAPRQLRASKSPPQGGGLAGARPKWTLHTRLDEGLYLLDADHSKCYEPNVAAQPTRVIKSSCPVIRTLWYQGEQPLSSMSNPAISTRHATCATREAGRNGSTTSKPNARTDLEHANFQAIALLRRSVSLNIKKQIKDGFDHTPTDVLKMIKKAVAAGTVTDIFIKLQALLDAGPPPSGVDAFEKYQANTIELFNTLSGYNLTFDQVISIRLIHFGKDLYKEYYTQALRQDLDKLPDPIEALQTLQTQAESTPAHKPVAMVASLTATDRSSSTPSAPCRHCGGPHWNRKCPVKDKKSKASSAPSASLAAAPDISTLVDGPVRGYLTAAMSTLAKPSLILDSGATHHIVNDRACFTNFRKCKPAPLEGITGEAVNSIEGVGSAVVRSFDGSIGQLHHALFVPSAPVSLFSASRANAAGYDINLSRGKATVSVDGSICHTGEITNGLYHMHASLVDVTTLIEQPVNMEVALNEDLKCDTCQAGKITHHPFPTVASNRSAQPLDRVHMDLLAFDGAVSLGGAKYALVIVDDYTRYLWAIPMSHKSDTFAAFKSWLAKVERSSSRKLLAVRSDNGGEFLSNEFSSFLEEQGITRQLSIPDTPQQNGVAERANRSITEGVRSMLHQSGLSHALWAEALATYVYVKNRSPHSANSGVTPHTRWHGSKPSAGHLRVFGCRAWKAATTEARSKLDPRGIPLVFVGYDLESKGYRLFDPATRQVFKSRSVTFFEDEFPARREGITAAHAPVAGDDDDDDDDDDEVVVLPDQHANQAPPDQAELPAALRFDAPGPAWQPPVGSRPRNPPARYGALASLRSTPSAFAFSLGKEVTELVADLEAAGIDTSKANRPLSEPEDPFSLPSSDPTTWNEAMRHPHAAAWKAGAIEEFRSMKDDLKVFSVVELSSVPKGATILPSRHVFRTKRDKAGKMVSLKNRIVAQGCAQGPNSFNNTFSPTAKYTSIRTLIAHSASKGHHIIQADVDKAYLHGVLEEEIYMRVPTGIEGYEGKCLRLHRSIYGLKQAGRVWNDTINATLASLGYRRLACDECIYRHEDAGGDHYIALYVDDLLFFGPDLGEIDRVLDQLDTLYGVKRLGPAEWVLGVQVVRHDDGGISLLQRQYLLDVLARFNMSDCNPCKSPMEANLQLSPEPDTDSADNAIYRSMIGSLMYAVVATRPDLAHSVGYLSRFVGKAGNTHLEAAKRVLRYIKGSLDLGIHYTRTSAPLLGYEGYSDSDWGSDIQTSRSTMGYLFKLAGGAISWSSRLQPRVACSSTEAEYLGLSHAAKEAVFLRSLLTELGLDTSSPLRLLGDNQGAIALTQNPVFHARTKHLRMLEHFVREHVRNGEISVTYIPTHDMVADIFTKPLPRVVFQRHCDAIGLRRISGQEQGGVLRCHIAVRFLHSVPLLTLHRCLGHLAPSSIQKMVAAGWLEGLGAGYSDEEVEKFVCNACLSAKGHRLPFPDSDSHSSERLGLVHSDVLTLPERSLTGKRYLVTFLDDYSRKLWAYTIGHKSEVFSVFKTWLAEVELETGATLKVLRTDNGGEYCSRAFTDFCKVRGTRRQYSIPRTPQQNGRAERVNRSIVEGILALLADAHLPKTFWEEAAAYFVYCKNLVQHSALDKATPNSVWQGGRTTASALHPFGCAAWLTVAPELRSKLDPKAVRVLFTGYDLASKAFRFYDTTTKKVTLGRNATFLDTEFPGLCGDSAEPDDDTHFASAPFADPQTTVKSWTPLVRCRIALVTVACAVLVTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKT0</accession>
    <name>A0A2X0MKT0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C022g09494 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C022g09494</name>
        <name evidence="2" type="ORF">BQ5605_C022G09494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MKT0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="AntiFam" id="ANF00118">
        <property type="entry name" value="Shadow ORF (opposite ucp12)"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ22490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="407" mass="45621" checksum="46F6A20781C6F14D" modified="2018-09-12" version="1">MTTRATGTLAEVRGSRPGRNELRHATLGVIALLLALGRINDVYDVRDRDRSFGDVGRDDDASYTLGSGLEHKLLIRDGDRRVQDVHFVPVRIVKVDAEQRVTTRFREDRLHVLDLIPTGQEDEHVTFLGLGEHVRDHECDQGERHVEVVDLADGATGVRVCRKSRHELSCEILYDRLFIEDPSSFLRGQSKRPQFFDNRIETMFFHGEASSRYLDDRRQSSRSLIGKVRRKQLGVDRSRHQHDADLVLAGLSTLMEQHAEHKEQQIGIDVSFMDFVNADVRDTVEEAMATCVVQIGLHASEEKSCRAEKDRTIRFGRLGLEADLVTDRITNSLAAFLGDTFGDRDGSNSTRLRAHDVALGAIATQDPVVQDQLGYLRRLSGTGGGQDDSDGRSGYLGEYGRSMRPDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKX0</accession>
    <name>A0A2X0MKX0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C013g07306 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C013g07306</name>
        <name evidence="2" type="ORF">BQ5605_C013G07306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MKX0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY15264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="252" mass="27996" checksum="E1CC0A4DB79C17F4" modified="2018-09-12" version="1">MRTRSSSVADSSSPSPPRSRRDTHLKAKRTRPNATSSTRRSQPTKTGTLEYAASEATARPGASKQQAPLVVLILGGRPFPVKKAKTKVRKGSEKRQSLNSSQTSKRTKTTPPAKTSSPTPLTKSSKSEDFPARLDSDAPLYFEFLKQHNFIAATLTKHAPATEKGKRNPTYNKKRDNALFEMMEGVYSERPDMAHFFSPDAKAHTSGRPVKRIIIERAIGWWKREKAKYRKAREQLGETGQGLTPWPGPLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLN1</accession>
    <name>A0A2X0MLN1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C024g09798 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C024g09798</name>
        <name evidence="2" type="ORF">BQ5605_C024G09798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ25913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MLN1"/>
    <dbReference type="STRING" id="796604.A0A2X0MLN1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050509">
        <property type="entry name" value="CoA-transferase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228:SF5">
        <property type="entry name" value="ALPHA-METHYLACYL-COA RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228">
        <property type="entry name" value="SUCCINYL-COA--D-CITRAMALATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ25913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="466" mass="50369" checksum="A60786FE01CB3661" modified="2018-09-12" version="1">MATHDLPLAGVRVLELAGLAPGPYTGSEFEGHSSHPRTLLSFSTASTVVLSDFGADVVRVDRAGTTFSTDVLSRHKRSLSVSLKSPSGLALLRTLLSAPSVRGCSNINCKCPQAKQANCMNNINQGVWRADVLIDPFRPGVLERLGLGPDVLLAANPGLVIARLTGFRREGAYGKMAGHDINYVALSGVLSLLGRKNDKPYFPANLLADFAGGGIMAVIGILMALLSRQKTGRGQVVEIDMVTGTRYISSFPLMMSRPSLGFPIWDQPRGENLLDGGAPWYDVFETSDGGYMSVGALENHFYTIFINKMLENAKKEYVPNPAPSPNTQMDRSTWPDLERFLTATFKTKTRDEWTTIFLGTDACCVPVLNRQEIDQDGVGKDEPGTRLTTQQFENGDGGVPGPAPNLVSTPARGPGDSTSFFLTPGKDTRRVLKEAGFEKETNKLIEEGAVEISEDDDDEGDVKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MM37</accession>
    <name>A0A2X0MM37_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C020g09068 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C020g09068</name>
        <name evidence="5" type="ORF">BQ5605_C020G09068</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS21 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000082">
        <property type="protein sequence ID" value="SGZ16807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MM37"/>
    <dbReference type="STRING" id="796604.A0A2X0MM37"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052837">
        <property type="entry name" value="Mitoribosomal_bS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001911">
        <property type="entry name" value="Ribosomal_bS21"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00030">
        <property type="entry name" value="S21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41237">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP21, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41237:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS21M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01165">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="32"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGZ16807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="231" mass="25551" checksum="7FC595A37036C3C9" modified="2018-09-12" version="1">MASLRTAFGALLRPRSSTPIVVATRAFTSFASVRSTSPSEPSTTTGAAAPPASEAKSGSHGASYQSQVLNQATQRLKSHPTPGKSANPNLRGPSFPSTRVPSSSRNRAPASDLYDWSRAMRSTPIPRTLQPEPQQSPEEIWASTNPIGYTLPVTTTTARSIPVKKRDVARACRALNRILNQNNVRKELRRQERFEGPSDKRVRLDSERHRRRFQVEVGKQVGKAMRLRQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MMR7</accession>
    <name>A0A2X0MMR7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C026g10170 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C026g10170</name>
        <name evidence="1" type="ORF">BQ5605_C026G10170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ27717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MMR7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ27717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="172" mass="19079" checksum="DCD0103EE1059BFE" modified="2018-09-12" version="1">MTAKTDFLFPSPTVDLSMTPHMISEFCTTRYPSLGDMSGISPARGFTKVLFLHSRLTNTFELLLGRMSTLNTCFPVHKRCGLMIVGGGKSMCKSASWRYEQICTNSCRLKNVSRRVMRKQPVMKSCVAAMMGSPLRGVTRLRLMFINWNASVRASSVCGTCKFISSPSKSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MP11</accession>
    <name>A0A2X0MP11_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C022g09498 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C022g09498</name>
        <name evidence="3" type="ORF">BQ5605_C022G09498</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MP11"/>
    <dbReference type="STRING" id="796604.A0A2X0MP11"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056453">
        <property type="entry name" value="HTH_DNAJC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052594">
        <property type="entry name" value="J_domain-containing_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23302">
        <property type="entry name" value="HTH_DNAJC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="21"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ22507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="353" mass="39730" checksum="096FD705CB5E7838" modified="2018-09-12" version="1">MESNPDPALAFWPDTALDSIDLYATLNLNRTATEAEIKSAYRRGALLSHPDKLPPTASEVEILASQLRFQRISYAYNVLKDEKRRKRYDDTGRTDEGRGIERSEDEWREYFKELWTGQINAETIDQFKKEYQGSEEELSDLLEAYDVHSGDLESISNHIMCSTIEDEPRFISLINKAIQDGRLRTCKKWTTSSKNLKARTTRINKANKEANEAEAYAKELGVHDQLYNSAGGKGKKERGTKGKETVKGKGNSQREEEVDGDLDGLKALIQGRQANRMESLMESLEAKYGAGAAGKKKGGKKRSSKEFDDEDEGEKGTNKKGKKKVVEEEMSEEDFLKARAAIDARAAKGRSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MP43</accession>
    <name>A0A2X0MP43_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="22">BQ5605_C053g12596 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">BQ5605_C053g12596</name>
        <name evidence="22" type="ORF">BQ5605_C053G12596</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000098">
        <property type="protein sequence ID" value="SGZ29865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0229">DNA integration</keyword>
    <keyword evidence="15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="12" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="16" id="KW-0862">Zinc</keyword>
    <keyword evidence="16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="21">
        <location>
            <begin position="626"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="20">
        <location>
            <begin position="1640"/>
            <end position="1653"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="21">
        <location>
            <begin position="2797"/>
            <end position="2969"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="19">
        <location>
            <begin position="3112"/>
            <end position="3173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="286"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="858"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1196"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1330"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1701"/>
            <end position="1752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="2510"/>
            <end position="2530"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="1260"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="917"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1196"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="1215"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1702"/>
            <end position="1713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1730"/>
            <end position="1740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="SGZ29865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="3175" mass="351442" checksum="9175EAC4823CD3EA" modified="2018-09-12" version="1">MSRKAESLESIGLLTRINWPAWAPAMRLALQSISAFRVATGEQKKPPASQPPNQSLKDYTSLCNDYDAKDAKGRTLIRSHVDENTWFKLKGSAVDASLHQVWTGLVRAYETNSVPFVGTKTLRAYWNLRYEPGTSVTSFMTEVEGLGELCNRQKMSFWKQQLGIGTEELQGFYAQIVDILGEERGKALLSMVLHVDDFAIKTVLMEQLPEKYTFAFREEKDVDLFLEKVRTAYDEDVIMNGANDKEQTEAPASALAAARQEADPGQAPPCNGNCACGQQPHAFATAGQHRGHAGPTRNSYRSGGHGRTGTRVGAKTRAEHYANSDKWGKIVGGKFMCANNQCVNCFGFGHRRAACDSRNPTGDRIAFLQSLDINVPVASHGTYFVEDPVPMSLANRMGASFHFTNYAAEVREQTIFRAVTAEAPELIFDTGATTSLVNDKCMLSDYATLDCPIFMIDAAGTRTPAVGRGTLTAEFALADGTTSKMTIADVLHVPNFVVNLIWGPSLCKQGVRIEMEEGRCEFSKDGQTFAIAQLIGSKYIFQARLSNLNPTEAQSLTVSVRSNSADREIWHQRFGHLNMPYLLEMERKETVMGLNIKGEDFDVAKCHGCMQGRGVHANISRGPASRADKPLHAIHADLWGPVRHESFAGEVMVLGLVDDYSRFRWSFPIGKKSSVTAFVVKFIQRVERSRDCNVAIFHSDNGGEFVNNSLKAFFRERGIEHRTTVPYAHYQNGVIERGWRTMFKTVRIWLLVSGLPLSFWAFAATAFTYVSNRRPTAALPGSTPFEMYHLRKPNVSRFRVWGCVAYVRIAPERRASKIEPPRVKARFIGYAEQGWMFWRPDTNTVFVSDDANFDESSFELHRGNSDDADLREDSPTTLFGDPPTGSLDIDGDDAVEQDFSLDGAGRAQAPGTDDRATAPIAARRAFAPDGDSRDNTPPVGRARAPDREYTPAAPGCERAPGNRVQHSDGQELTPIVPTRRAPAPVVSNGRAPAPVAPNGRAPAPVVPNGRAPAPVAGDGGAPPPVASRRPSPFLDDDADNDPPDPNPIPDGYEPVVPTTERTSELAERWGAPAGSRRRGGAEQQAMFVDLGTILGDVIPLNELPEWEQVLSVVVNLEECNGWTNLSSIVQGSTEGICGIEELEAYQVWTGNPDEPTYKQASTSSEEDVACHFFQVRHRQPSISLALALSCILDEQSSTTPESSHPFSPQPPTAKPRTRHGRTHRHVARHHRPVREDPSRANPPKSPPTHSPHPLQAAAVITSLESRLAESEALRRDSETRIRKLEQMVERLMRESTAPAGAQVGEALPVRPVPLDVPPHTFLGRPGAAADPLARTPGGESHSGIRDGPSSAVISSRWRGTLPDREGLWTGDHPERLVIFTAFGESYLSLLCDISTSDLFDTSRVIQLVATLFSRTTTRQRRQSPLDWAVEAMRDALGEGRPHCWTSLMKAVGRRWPDPGFADRVAQDFHGCRQSSSRAYDHVGEWRARYRAFVHDNDSFTLSPLQLATTFYQSLSDSSKREVRAGMLREYHDNSLVTIGRFGLKVPSIDEITEWAAIADDISPPPSVPTPPSRTATYGAIVKAPRVSPPATNTPTVDERFQIRRARWVDRATKWQQSHLWKDRSTWFSPAPSGVPTSMACFNCGRGGHFSQHCTAERQSPVAVQLSAVAVADLDDEDWSSVAGGDEDPEVRVPISLERVQTRPLSSVSASMTRPSCPPADPVGRMKEGASSSVDVEVSSSNPQPTAPASDADLRRLADDSTDSAFDAVEDVPSYADAASRMRRYWGPEVVSSRKAERTASVSSVRVPVPLGVSLLESDTPLIDVDDFARPAEPAIVRARNIIAWTLPSGRTLRCLVDSGSEVDLVDQDVVRTDPSFTTSRLTAPLHLRLGTRDKSDRCAVFANALFTSGSLDLGLRAFFICRVTAYDAILGLPFLKDTGMLVGWGVFTVARPGPSQPVAKGTHEWDRAVTVAPICSGSAIGYDHPGLLPDDEIIGLEPHNPLLDVVDDPALEDLSESEARTRLAALLEKYSDVFVDSLPMDRLPPYRPVNHEIPLIDPNEKVKPRVYPLADKYRSQWAEHSAKYTRGRFWVSGPIDSAAPVFAIPKKNSQTARFVIDLRARNSNTAKRFSPIPDMTSVRYEVARSRYRSKFDVAAAFEQVRVIPEHVDRTGFATVTGTYTSRVMQFGDTNAPNTLNLLTSAMFQPCLSFAKIFFDDVHVHSDTRRAHLRHIEILLMTLRHYRFYLGSNKSEWFSKSLDSLGAIISDDGIEVDPAKWERIRQWPTPHNKTDVQRFLGTVNWMRDHLPHLSITLEPITALLAQSTSWRWNEHEQQAFDTVKSLVPATLRPIDGAKVTSGEHKIYLFTDASRVGIGACLASGPTRSQAVPTRFFSAKFNGAQLNYHVTDKEFLAVVSACRAFEQHLIGYPFVIVTDHQALRTIKTQKLRQTPRHIRMCLELSRFDFEFEFIAGKNNSLADSLSRLWEVKEGSPEDQVKENELEDMFFDGERHGFTTHGESLPEERPYTSPSPDRLPPVDFAFGPQRDDCEAGSPGYYALKDESQDEDVNGRDLGNLFLKEECHEFTTPGSPGSHRLAENIMDTVDSSTGPLSPPIAVNRVQAIAAAPANDAPIPVDADADELDLLGAAADEVNDAPVVHRPPDPLPQPFLDAVIRAYAHDSQAQVIVDDPLSWPMFRVTEEGRILRVHPDESLSLFVPRGLATGVVDSDKVPSLRELVLAEIHRSVGHAGHRITLAAIRPLYWWSSMSADCAKFCHSCEDCARGKASTQVPYGRLHPMPIPSGPWEQVAIDFMTGLPPVEFEGMMVAQIMVVTDTWGKMVHLIPLPADADSELVADRYYATIFRLHGTPSAIVSDRDPKFTSQFWRALQAKVGTVLRMSTAAHPETDGSSENRIKMVTQTLRIMVSSNHEAWASRLVEAEFALNSSVAVSTSLSAFEATYGYLPRRWPTDSWSVSDVPRAEAFARIRQLRNLDVTDAIIGARLDQTHQANKHRRPDDPAFRTGSYVYLSTKNLAVPEGMKSKLLPRYIGPFRIRAAIPATSSYDLELPPAMSRVHSRFHARLLRPYVENDAERFPGRDPAVLFVEDVADAADNSAIPERIVRDRRNARGNRSFLVRWIGRKDIDDTWMSEQSLRFDHPSLLDTYLAQLDRSNRRLSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPC2</accession>
    <name>A0A2X0MPC2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C017g08381 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C017g08381</name>
        <name evidence="4" type="ORF">BQ5605_C017G08381</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY19915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MPC2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retroviral polymerase SH3-like" evidence="3">
        <location>
            <begin position="128"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="398"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY19915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="798" mass="87837" checksum="6F2AD9E13B57BDFB" modified="2018-09-12" version="1">MEHQYSPSFWCQPDGEGTEEARCARSLFLIPVARSKARALHTAYEHGQMGVQERSWRTIFNSVRAWLHRSGLPPALWDEAAHAAIYVINLLPSSPLQQRTPDSVLHEPSDLVTDTRRPRLDRVKTWGCAAHVPLAPEQRPNKLAPRSRLCYFVGYSSRSKAWRFFDPVCNKVFESSQARFFEDRFFPAAVSPAMPAIPVAVGLSYPPAPLGIGSAAAPPVAEAPAVAPAAAAPPPVPPALAFSNPGPANAPPDGDRSTRTRRPPDYLGFAHAAQHWEFADHAAIQFDDFDKGDPDTQMYSFEEVSALLAKIDSDDTPSVQAALTGPFCDYWLAAMSVEEGALAAKNAFSKPVRPPPGAIVIGSMWVLLVKRNAEGQIVKYKARLVACGDMQRRWGNKRETRQFDVSSAYLNGNLGGTEIYMRLPGGDIVRLQRALYGLVQAGREWYKVFTEWILSIGFTRTDSDHAVFVRKEGDRRSFLSIHVDDGLLTGDGDLDGVLCQLKARFEARSTDEASFFLGQSIRREGKTGAAIVNQGHFVDAILEEHHMANASPRPTPLAAPSTLRNCADSGFDPASIPYRAIVGKLLYLSGTTRPDIAFAVSKAARFCNNFTVEHWEALKHILRYLPMSAILEGFVDADHGADPVTRRSVSGYVFMCAGGAISWIAKRQTLVTLSSTEAEYVAMSYAAREGIWLRRLLADLGFEQTAPTCLRGHNQSAITLAKHPAFHARTKHIGIHFHFIRDHIAEGTIEMVWVPTGTMAADVLTKGLGTQKHYQFVHAMGLIDSSREGASWRVVNED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQD6</accession>
    <name>A0A2X0MQD6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C024g09803 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C024g09803</name>
        <name evidence="1" type="ORF">BQ5605_C024G09803</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ25935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQD6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ25935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="110" mass="12183" checksum="84D595F38525E1D9" modified="2018-09-12" version="1">MIDTRARKSSEVIAGGTAVLAVGSIVDGFNNLRTIPKMAATLRRVNNIGRSPHRPSMNLAMNRYVRAIASPSAEVEVKVRFISKVGKTCKRFERHPELILVDPSGPRRWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQS9</accession>
    <name>A0A2X0MQS9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C001g00452 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C001g00452</name>
        <name evidence="25" type="ORF">BQ5605_C001G00452</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY46610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="520"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="762"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="875"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="23">
        <location>
            <begin position="775"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="786"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="23">
        <location>
            <begin position="799"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGY46610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1454" mass="161013" checksum="71DEE921E3C37877" modified="2018-09-12" version="1">MSSTGESDFPNGSGNRLYLKDTQGYKSWSQRAFINLRADKVWDVVNQSIDSLVADYRSTLVIAHATASVAPVEPASSGFSGLGGGSGSAHSDASPRLTSVQVADKVAEYRERAIRRNDLACKYIANSISEEQMSHLIHLTSAYEMWDTLRGLHSHGRPSRTMDLLNTLAQPYSGYIPFKEFVNKVKITMTDFQNLGAPLPHWLFAGMLVRSLPAQYDSIVGNLASDIDIHMDWNTFYPKLLMNVEMADSRNKQKESLSARIVDDTSLVARISTTAQKDYSKSYCSRCKALGHERGWRLCPSRNKDASAPASSDSNSNVAAIGVDESALMTYTFPYSRTMPRFPWIIGSGAKVHCVGDKSVLSDVVSEPLKISVADQSQIESPGHGSVTFLTSYGARITIKRVYYMPGAQCGFISIDRLLESMTYASILRSLPGRGFVIDAAPVQPIMSSSPPSMVGANRLTGTCTLMEAHRKLGHQSPAAIVLAVKSGAITGITLKDEKVTPCFSCIQAKSMRSPFSNKSTEAPHALYRVFIDLGFVEHPNHHGDTIYLAIVDQYSTAKWMIVLKDKRAETIIEAWSKFQAESERQTGQKIKRVRSDNGREFDNSLFRALLEKPGIIVEFTAPYTPEQNGQVERLNGSLMGLVRSMLLDSGLPMRFWSDALAVATFVLNRRPHPRIQGKTAIEVLLGKKPSLAHLQPFGSTAFVHVPKERRSKLAPRSIQGVFIGYSGEYNYRVWVQSSKQVYVSRHVTFLETPSVVTLSQDRADASDPVHQSQPPHPPHPPPDVLPSTPTSPVVDPTLPDPQPPPVVPIGVGQQGGYLAVIPRKDDDNDDRIWTSANDGVTFTRSESDFRLTVEWFFCVMIVIRSIERLQDKRLQDNDDNDNNDGLNDGPDNYHDAEEPLDGEAEVALAPREGYAIVCTGPNPGQFENVDPSNILPAGSRRRPQPPENILPIISAIMVDVLDTPPMFHDKLSHDAYCAAVFAEEDIEIPKTFEEAMKSPYRNHWSAAMVSELLQFDHHGVFQEVKWHEGIWVLGTIWVYSIKRNANSKIICIDYHDTYAPVARSSTILFLIALAAAQGLYLKQLDFNCAFLNGKMTEDVYVRYPKGWNHPQSPGQCLKLVGSMYGTKQAPREWATADACLYIKHSGTSFAIITLYVDDGLIASNNQSFLDSELGSLHKAFQLKRLGPVSYFLGFEIHHTKDYILVHQSKYVRTMLEKFDFASPSKRRAITPMDDRPSLRIDATPFANVSLYQSANSCPTVDDWAAVKRIFCYLNSTINLGILYRNSSTTRLMVYSDASFADDPESRRLVGAYASMLAGGVISWQSKQQSMIATSTTKAEILSASSPTREAIWLRRLAGDVGIPQAQPTIIQEDNAACIQIAKDPVELEYCPTHVNAADIMTKPLGFQRFDQLLALLDMVSLVSLTGGSSCRGVPLSPCCNKLHLCRSELKSCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MR77</accession>
    <name>A0A2X0MR77_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C041g11949 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C041g11949</name>
        <name evidence="2" type="ORF">BQ5605_C041G11949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000119">
        <property type="protein sequence ID" value="SGZ33255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MR77"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ33255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="91" mass="10120" checksum="B81DE9F803CA87D9" modified="2018-09-12" version="1">MYLDDPDIEPLDDASRLPLRQPTADTQITQIQLSWSTDEPLESDTLPRPLDAWRDKFKDRGAITAARKQGYRSIAIAGHRLPFGVEGSGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MSW7</accession>
    <name>A0A2X0MSW7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C047g12291 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C047g12291</name>
        <name evidence="7" type="ORF">BQ5605_C047G12291</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000113">
        <property type="protein sequence ID" value="SGZ31035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MSW7"/>
    <dbReference type="STRING" id="796604.A0A2X0MSW7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008841">
        <property type="term" value="F:dihydrofolate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06503">
        <property type="entry name" value="ATP-synt_Fo_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF0">
        <property type="entry name" value="DIHYDROFOLATE SYNTHETASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="17"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="48"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGZ31035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1278" mass="143585" checksum="6F1653117AC980B4" modified="2018-09-12" version="1">MLGFLTESTWLRHVTSPFDHRHSSSPSLSDQGPPKRARGRPALSEQQKAARNEMDKKKKQALREAKEAQRDLQREAQRVKDQAEKERLEAKAETERQAAVLRQEARMQMSSTRSSLAIIHSYVLFAVPIFVIYMTANRTRLIESTPNKRNYRRHHKGGDELVHGFLPVKSAWTRLYDGCISNANLDIYEPQFFYWDPLLMIGQPDDKRAGVGLRLNGFLDRPRRACGLREFVYLIGRSYNCDNKKCSKTYRSWSPEVLDPLDPSLRSMFPSILRSSFHYGLGAEQISDMLVCFRRGAHDRLELDYRSAIYVPTSKVLAIFFNAKIEEHESLIRHHVSLAPCTIMSRDHSCKLRTWKRGNLSSSQVPKQIAKINGIPPFHALLMVGNEYGKVRLAVLTATKGHASFESPLEDMSKHLKLYGHEQPSICYTDQPGQDTTFLIETLPSLAPTLGTNAGPRQGDLMLPPETTPVQATAPANSYRNVAIAASKKAVDVVQFAWESLECDLFIHVIQLSQIIQKCFKWRLPPPLRHFLDRADILKVGVGVAGDLTRIVTPSRTRSAGNLRSMRRIRSVLPKLQASRGVGSRSLAHFSKRFLKKRLPKDQSIHRSMYWAETMLPPRHIMYAALNAYASLLVYKAIIDSSIDETCTPPSEFHGFKWDKSRAVVDITQILIPGALVPEYNTNAMTFHSAIFWPYERSQFNRTLTATFAPNAVTDHSRCFLRSMLSWSTWTMRSPSRVPSTAQLTRSPLDVGAVANSCTRETEMEEHTEDFDDSLDAATAEIEEALLLERCETTAVEISAILDAADGNKASSLDDPQLRILMDPFHFFQRIYLSKKHGATRAFLRALSDAISVVNLDDKHLVSIRLAKAMMTFDEATRSPAHAKYIWKRVRRTIPPPSILEPLVREVFEAFGSLLDAKTKQPLFNKAALLVTKRCLELVRKGQLSDPVGIELYTDLGPCRGPDGTADDGVRLYSCRRGTNGLEGGIHRNLRARFAKSGVTPRHANARLLDYVLGHNLTVSWHIQSHWGGFHRSFRLMAHSGSVSTPLPSTRSTTLPDPIRVKLPLPGSYQYQNSAVALLAVELLRTSRRPLSLVPALSNVSPLAYRKGIEVTRWVGRLDWVNFSSELSRTKHPILIDGAHNPSAAEQLHQYLHTLAEDSAPTTLITAISAPRPPTVLLEPLLRPRGSIRKVVCVSFSRPDGMSWIEPTPPEEIRELLLRDPAFEHVQEVQVFGEVEQALKSLGEADRVVVAGSLYLAADVYRLIRRGREGAAEAEADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MTG0</accession>
    <name>A0A2X0MTG0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C047g12342 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C047g12342</name>
        <name evidence="3" type="ORF">BQ5605_C047G12342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000113">
        <property type="protein sequence ID" value="SGZ31233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1067"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="940"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="449"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ31233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1797" mass="196720" checksum="9AB649C537B75D51" modified="2018-09-12" version="1">MPDPPGAQAPPPDNPLGGNRASDDESLNTLTREPVTGGTANPPAWSTEATQARLDCEKVMQNTFRVLGIVPSGKSTRRLMVLMHDASTPPSQAPLLARAAQRAVRNDAAPASNVIRVIMDGPGSPRGPVQIALRKHFGLAETPFMFARPEGVVLDPEVEKLFSKCVKLNPIVTKATKRFPIARHMYELVFESDQACLEAAAAGPFSHHGKEMVTELPSASPLNHVVQVRFTLPSSSSATPASVLRQSLDDALTLSFGRAGRTQGYTLMQLQRGLAVDPNGDPMAMTEDGFHCAYLRLHADLFQGSTETQKAALNAALPQEIEILGAKYGLRHEFETHYCAVCDRAGHQWGACRKPVSTPATAAPVPGASTSTSTTGFRVAGKNGKHGGPAALNSRASGTNMIQLGPRANPAGAATGNKDDANDDDGGGESVASTEPEGGDTGKETLTRATTGPTKETQTTTAAPVSTPTSPSPSASAPASPLSGGTSESSATSTTSIASTSPRRLRSSSAPGNRRVTRAGSAMILGASGGDGSGGNSSGSLTVLTFNVRSIKNAVNQVKIIRYLKTLRPAPAAILLQEHHLGYNASREGFESAWPGACIRFTPHVLTLIPDGSPLAGHLLSSTPVVFAGAPRLDGRILRSVFRLEELDVEIINMYAPTKTLRILAGDLNDCPDVSVDRVSITDRAWTPVSHWQTLLSKIAFKALDTVRHVHSCTPAFTRPHYRGRGEERKICSWSRIDYILVQCSWANRLLSASTLFDAPCSDHRPVVATFALPTDFISRLNPTVFDDQDFVASIPGVVDEVYRRLEGTAPLGDVYDAALRAVAVAGHARYRSTRADMRRLRAESQSVMEALEARGEHMNEAERDAYAFAKSRLDQLAVKEAQWLRIRAHVPSVDSREGQSASIRTRLNRRSRQTSIVSLEDVDGTETVDMQEALGIASRHAQSLFTPDPARGDPTNPRRSLLDPIRAAKCYDDDRSDPTFGRRLPRQARVALDEPFTLLEVEAALKKTDSGRSPGPSGIPYELFKALPTYFAPKLLDLFNSIWEGGKMTASLAEGLVRLLPKNKPGANLKSLGAYRPITLRETTYKVLSKVLVARLNGVLGELLPPAQHGFMPSRRSADAGSHLTLLLEKLKSLGTEVFPEGALLSLDQQSAYDRVDHAWIFDVFEAFGFGERFISLLRALYDPETLGVRYLINGFPTELPFLDALVRRGIALDLQKVWPGGPRAQLTHLAFADDAVVVVESPAGLSKLETLSQTWYEATNGKTNTDKTLVLPLGPNWLRDETAQALPTVQEGRASSGAAMPSFAMAKARAARDRTLSPSGRVFYANAHITSTVLHVLSFDIPPQWFIQAAETALTDFVWGGPRRNTVAREFVFQAREDGGLGLISIGDIVHSVALRFWDAVAGSDEAIWAPLARESWRSLVAATRDFSPWGFFSSTARVEKLYRDSARWGAVVAAARVTLPTIKSELLTLPELLSLPPRLPSLYAEGAKHAYDDADAVAKFAQIADLYWRDEGKGWALVGHRRGFWQHSKEPALQHEHVWSRVGQLLKAKALLPKTALRPARIPLKEAPRPRCFNFFGLTRPFTIRKLRRFVNVVRFPGREDRVKRFRDGTSQSDRKRFWRWLHDRFASAVEQDTHWRLMYDVTPTRKRQHTQGHASSPTCLFCGNDAAVIETVSHYFFECAYSTSFWGGVLRILFDKLGIEDTDVDPSTFTPEQLTMGLPLLRGRGRTTSRWMWVRLACAIGFQRLHLLRWRVHQRFELDKVVAPPSLPSALRAFERDFLSRAGFVPGARDWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MTQ4</accession>
    <name>A0A2X0MTQ4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C002g01507 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C002g01507</name>
        <name evidence="7" type="ORF">BQ5605_C002G01507</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY33518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MTQ4"/>
    <dbReference type="STRING" id="796604.A0A2X0MTQ4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000720">
        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF360">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="366"/>
            <end position="372"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="461"/>
            <end position="464"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="519"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY33518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="547" mass="61153" checksum="45639BF2634AD3B2" modified="2018-09-12" version="1">MATINSRLEDSQSDPLVIFHLPPPGETAVQKAERVSQEMEAKHISQQALRRLPRFTRKIDRALEAEAKERRRRAGNVKQLDVLLLGPTEAGKSTFLRQLRLQYDVKGLDAERECLRLVILLSLVTSVKTLLDVLDRQDANDDTPLFDARTTQPPLREPKTPRELAARRRLRLAPFLALEHQLREALDLANTGTGAESIAAHAAAPPSAQLHNDYQDESPVDEVALTLNIEHRGAQNSPPPSDPIVPPGRLAQLVSTVGFGTGKDSRRAKAQSATQSPNWTSDGKFFANKDDPIHLVAALKNSIVNLWKEAQARGLVVGVTTPGDPSAAPQTVVDGAIELNESSMFFLNEIDRIATPEWLPGDQDLLNVRIRTRGIETHDLQISSKRVYRICDVAGARGSKFAWAPFFQDASAIIFICAVSEYNVCDPTDPTRNRLRDALLLFKDICENRLLRSADIITFMNKVDVLRRKVKSGQYPIQRYFPRYLGSDRTSRILSFFQTLFEECHRVRRRPFYIFATQANDARSIVTVTAAVNDILIRSEMTSTGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MU22</accession>
    <name>A0A2X0MU22_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C075g12918 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C075g12918</name>
        <name evidence="6" type="ORF">BQ5605_C075G12918</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000128">
        <property type="protein sequence ID" value="SGZ34786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MU22"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003840">
        <property type="entry name" value="DNA_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02689">
        <property type="entry name" value="Herpes_Helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication helicase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGZ34786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="86" mass="9258" checksum="6F8AE8CF4CDA4151" modified="2018-09-12" version="1">MTINKAQGQSLDRVGVDLSLHPVFTHGQLYVALSRAMSVDRIKVLLPSRDPADDDDDLQAVDRAAAAATATPNPVFRSVLRAMNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MU29</accession>
    <name>A0A2X0MU29_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Guanine nucleotide-binding protein subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C007g04419</name>
        <name evidence="13" type="ORF">BQ5605_C007G04419</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">G proteins are composed of 3 units, alpha, beta and gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G protein gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY60359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MU29"/>
    <dbReference type="STRING" id="796604.A0A2X0MU29"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031681">
        <property type="term" value="F:G-protein beta-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.260.10:FF:000003">
        <property type="entry name" value="G-protein complex gamma subunit Ste18/GpgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.260.10">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015898">
        <property type="entry name" value="G-protein_gamma-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036284">
        <property type="entry name" value="GGL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041848">
        <property type="entry name" value="Ste18_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28189">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28189:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00631">
        <property type="entry name" value="G-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01224">
        <property type="entry name" value="G_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48670">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="G protein gamma" evidence="12">
        <location>
            <begin position="15"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGY60359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="88" mass="9809" checksum="9AAE2D118EF020BB" modified="2018-09-12" version="1">MNHNNSNSNKKPSMSELKLRRLTEHNQRLREDLERQRVRVSEASASLIRYCKTTRDYLVPSVWGPVEKGSDPYAAAASGGGGGCCMIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MUC0</accession>
    <name>A0A2X0MUC0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C077g12946 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C077g12946</name>
        <name evidence="5" type="ORF">BQ5605_C077G12946</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000126">
        <property type="protein sequence ID" value="SGZ34548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="497"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="291"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="791"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="301"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGZ34548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1365" mass="151276" checksum="9FB46AC81DE9D46A" modified="2018-09-12" version="1">MVLAVARARGCCAGGPAEAAGCLHEIASFWPSCYEPNELPAAQESGEIKIAKLGKDNYELWSIRVEAYLESKGYASVLEHGHVRPSDVSLAEWRTMHGLDASVTDTQVVVNLQKKDRSARALIIQCIDDANLKMVKSKTLSAKDIWDKLRQHHEGNAKPFKIRTLLMELSNAKYDEDENMGEFLKSMIDKADQLDDLGQKFGDEAMIAYILQALPPSYEMLKQAIRLGENRSVDHVINRLTDEYTERKLSGKFDKLLKNAGALAVQSTQASRDPNCVCRGCKGKGHFAMDPECPKYDAKKNHGRARNRNKKKKQDSKESADSNELAEFVLTVKSLDESHSLQDNVANRVSQLNQGEIWILDTGASQHYVGDASLLSNRQSGNLKVQTASGQVVHCDTYGMVRFKLKSGASLSLANVYHLPGAPVNLISTRALFKSGAKCGWEDGKDVMTITYQGVILAKTLSGTGYALDFTRIVEDQAHVATRATVGAPLMEWHRRYGHVPVSSIMELVKSGAVEGLVTDVLQRVFMDIGFVAEDQVDFQGRKAYLAIVDQYSTAKWTFPLKTKSAEEVTRVWIAFRQGVEKMTGRKIKRVRTDNGTEFTNKLIGADFQSQGILHETSAPYTPQQNGTVERFNGSLMAIVRAVLAASKLSWKYWSYALAYATFVANRILHAKLEGKTAYEVFYGKKPKVSHFRPFGSTVYAQVPKSKRSKLESTSVKGIFIGYNSEYNYRVLVDPDSDHKVIVTRDISVLEHKSEQVGVPEVTTLPVGPDEEKGPVDNDEIVVDKLQDQVDGEQMPPARQNRPRWEYGDPAVKGRNPGRYEEIDANNKIPHRTRSQRRDAEQQVMYGSAMSVSLPPVPSNYEEAMASPEADKWIAAIKAELDAMARHQVLIDSDLPSGARALGSKWVFTRKENAQGEVTRYKARLVAQGFAQRPGIDYNETFAPVARPSTILSLVGTAAAQGLFLEQFDFDSAFLNGTMTEMVYMNRYEKFIYITLYVDDGMVASNDQEFLDSEIEAFNKVYKLKRLGPVKLFLGLEFERTSDYIFVHQSKYIRDLVAMYGGGSVSKHPVKVPMEPRSDVEHSTDPFDDVALYQSAVGALQYAAHRARPDIVTSVRAAASKVSAPTQADWIAVKRIIRYLQGTVDWGLKFNHGGSTVFELYSDASWGDDMSTGKSIGAFVSILAGAAISWQSKQQSMVATSTTEAEILAASAAAKEAMWLRRLATDLELEQPKATLIWEDNQAVIAIALNPAHHGRTKHYNVHHFYIRERVTAGDIRIKYCKTGAMTADILTKPLARNLFELHREGMGMVSLGALTRTYGLSSGAGARVLCGGPAEAAGCLHEIASFWPSCFSLFSTTHSISHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MVA9</accession>
    <name>A0A2X0MVA9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C007g04869 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C007g04869</name>
        <name evidence="1" type="ORF">BQ5605_C007G04869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY64097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MVA9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY64097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="82" mass="9363" checksum="26F02D6BC6B10706" modified="2018-09-12" version="1">MSTHPSAMSISPSSRVLVVPPDAESLRLIGQHLGAWLDKRRSLLPTWRMMIRCSLRQLVLSNVKLRLEQLQIVCQTHNLQGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N201</accession>
    <name>A0A2X0N201_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">BQ5605_C007g04761 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C007g04761</name>
        <name evidence="13" type="ORF">BQ5605_C007G04761</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY62971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0N201"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF353">
        <property type="entry name" value="ABC TRANSPORTER ATP-BINDING PROTEIN_PERMEASE VMR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="468"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="585"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="674"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1091"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1163"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1240"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1264"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1348"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="434"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="784"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="1094"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1439"/>
            <end position="1719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1557"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1566"/>
            <end position="1580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGY62971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1737" mass="191202" checksum="0F0784E0EEF73C40" modified="2018-09-12" version="1">MDAQITFNTRVNGDAWCVNDSTPHWDGREFSRCFMRRTIDGLIPLACLSISLLSTLLITLFHLYLIISRRRARNKKAVSSSRDRAPHRRRRSSIASQEIKRAGLSAITEAENEVILAVVRDESPDLSAKELETLAGETGSPSAIDDEDEELERATLQLGAGMVASAMWSNKKDVLGLLGAAGVLGLSVVKMLAATDDGANWLLFGITTWVSRPVLGSPYPGSRSLTSPESDSFQSWMTLLSLVKLAISVSRKLGSLQAPKRPHRGLPRVYTFLELNLIPWLLVYQVIAFQDVYDALTSSRPSTMREIRIEVALFALTLAMTAVEMFSPRPTRSSSTLKGVRHPSAPLENNVSLFSRMVLGYLDGFLLRHTRTTIKAEDIPNLDPDDRTARRMLQYRCDCSLLLRILPQRARSFGMATKLLFHFRYPLIVQQGWALLTALSRAVPSLFLRGLLNEIAKRNRGEEAPLHVALLFVIGMFFSQFLATVAASQALAIGRRVCIRVRSVLIGEIFTKALRRRDLAGASVAQSRSAEWSDPPTVEDGYSPDAKELDRASNGKILNLIAVDSFHVSEVSANLHYVFPDLSLTIIIAILLLINLLGWAAVAGVSVLIALIPLQTYLGRRYNHFQSALLAAADARISLITEVIASVRILKYFAWEEKFLRMMDVTRRKELDALWSRAVMMAVADITFNGSPIIVSLATFLFHTKVLGRDLTASDAFTALSLFNLIRQPFETVPHISKQILEALVSLGRIDQFLNEQETAKYAVVKEPRTGSDPIVGFTDSASFTWADEAEAREDLSVFRIRDLNLSFPVGKFSIILGPVGSGKTTLLMSLLGETNQLSGSAFLPSPVGRSTGEDPAILTDTTAYAAQSPWLMSATIRDNILFGSPMNERRYKDVLEACALNPDLKQFELGEDTEVGEKGTVLSGGQKARLALARAVYSPARTILGDDVLSAVDSHTAQHLVNKCFKGPLMRHRTIVLVTHAVDLCLPVASYVVSMDAGSVISVGSPTEISLEEEFIAKLDPKASNHNVSQVSIESIAEGQTDAAVAAVCDDEYRRRQESLRLIKDETQSEGAVAPKTYLMYFRAMGGFEIACVSLSLFVIAQAAEVGVAYALREWSSSYDHLHDIETNRWNHAARYSEHSPINLPSAKSEEVGSQETRSTDYWMRLYCTMAVINLVFSGARFAFFSWRSVIASRVIYQSLVTRLLRAPIRFFDSTPQGRILNRLSKDVEVIDQQTANSLMFLLLEVLGVFGVIITVTVVLPGFLLASCLISIIFALVGWLYICSSRELNRFDSVSKSPIFSIFGESLAGVSTIRAFGDSTRFMRNIFKLVDLNNRPFLAMWQANRWLSFRVDVAGVGITVAAAVLILLTPSIDAGAAGFILSFTMSFMDRILWAVRLWSMVEINANSIKRVQEYLEVDQEKLDGVSPPAVWPSRDGTITVENLTATYSSDLPPVLKNVSFSVAPREKIGICGRTGSGKSTLGLCFFRFIEATSGRIVVDGLDIAKLNLLDLRSRLTIVAQESALFAGTIRFNLDPFEQFEDSDVWDALRRVQMAAPLTPKPTPAATPAGPSRAASPTEDGSGESDGSDDATATVTPVEGLERNIVKSLDMQVSEGGKNFSAGQRQLLALARGILKLRTSNILLLDESTASLDQATDEHIQTTIREQMSDATILCIAHRLKTIIDYDKILVLGSGEVLEFDTPANLLNDKKSVFADLCRRSGDFDELKAMAEGKANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N294</accession>
    <name>A0A2X0N294_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C036g11557 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C036g11557</name>
        <name evidence="25" type="ORF">BQ5605_C036G11557</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000063">
        <property type="protein sequence ID" value="SGY96298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="534"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="777"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="23">
        <location>
            <begin position="802"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="23">
        <location>
            <begin position="838"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGY96298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1848" mass="203795" checksum="6374152D22105E48" modified="2018-09-12" version="1">MSHTDLPANIALPDSNDKNSMAGNNETGTPPPPPSPLSSQPNIVVPPMHVLLTREQFDDLVKKCRSVNDDDVSKRNLLPPTSPPAFPDESKLSDNNYVNWDLTMSLTVPRKVCLYLRTGCHDKAWLPKLHSQWEDYAARVLAGSLTTVAKGTIGPAAQKGGNAHACWVALTKRYAPSDAQSHSTLIRDFFNMPKLPSTWAGFNGWTNQAMPNKSKLPVVEEIFASMESVARTLCNKSTPALVAQTPSLTTKAGQNRKGRWDRSGPPPGNCPACQQGKHWVEKCPDITRRNKYLELKAALKEFKGVSPPSAPALAANDNNAYMAFFAAPAFVNLSKSANLLLDSASAYHVFNDSSFFDGPISPASHVMQGLGGTVNTSGIGSVKLIMDSGTKLILNDAIYVPESPANLISVWAFDQKGVCITVQKGHVELSTAKGCIATATAIESRVYKLNATVEVSSKGAPPAYVTTASTRPPLLTLHCRYGHAPIQAIKRLAASGQVKGLDWTYSDSECVEFTCNACLASKAHRSPFPSSLSHAAEPLALVHSDVLSFPEESINHFHYLVTFVDDYSRKTWVYPISHKSDVLPTFKDWLLEIENATGHRLKTLRSDNGGEYISSVFNGYCAARGIRRKLTIPYTPEQNGRAKRVNRSIVEGTLALLSHSGLPCLCWDEVAVCYIHTKNLSSHAALKGGVPNHRWSGTAPLVTALRAFGCCAWATVPGHRHDKLDPKGIPLVFVGYDRHAKAYRLLDPTSMRVSLSRDVKFVETEFPFLSMPKRTTAPSIPGYRPIAQPMLQPEGPRATPNQLPPPNDELPPPNDKLPAPDDEAASVRSDATNAAEVLPPPEQVPEPPAKVKPAWEYGDLARVGPDPGKYGKVDPRNIIEGPRTRRRLVPTMIAKEQLNSGPDGPTNAFKNLILAFAATTEGFAEYDLAMVRDPANWGDVIRTGQEEVWHPPAGNEFDLLLNEYEVFEIIESCDLPLGEILLRSGWVFRTKRNQHGDITDHKARLVAHGCSQRPGLDFEKNYAPVVKFTSIRALIALAAANGYHVHQADINKAYLHGKLDKPLYMRIPQGINLPGKILKLSKSIYGLCQAGTIWNAEIDSTLRLLGYIPTKSNICIYRRDHDGHLHYIALYVDDLLLVGPSIAEINRVLDALELIYGIKRLGPAEYILGIQVKRGQDGSITLSQERYLCDLLDKFRLGNAKPASIPMQPGVVLDFQDLSATPQDRTRYLQAIGLLMYAAVGTRPNIAYVVAYLACFSQQPSPVHWTAITQVLRYIKGTLDLGLTYRKNNVTFHGYSDANWGACLTTSCLTMGYAFIYSGAAIAWCSKRKHRVAKSTTNAEYLSLLYASGDTIHLSELLAELGHPVPGPVVIYGDNQGYLALAQHPTNHQGSRHVRISEHYVRERVAEKEIDVVYIATADMFADIFTKALGPKPFLFHRENLGLRVNQVKIIRYLKTLRPAPAAILLQEHHLSYNALRKRFESAWPGACIRFAPHVLTLIPDGSPLAGRLLSSTPVVFAEALNLTIINMYAPVKGEERRNFYGLLHFTAPGPKTLRILAGNLNDCLDVLVDRVAITDHAWTPVSHWQTLLSKIAFNPLDTIQQLHPITPAFTCPHYLGRGDKREICSWSRIDYILVQRSWANQLLSASTLFNAPCLDHRPVVGTFALCCGKLVKGQRSRGTCGIGKLARAWRGAGWRQMAVMSSTTTTNVSNEGDIKITKLGKDNYELWSIQVDAFLKGRGYSSVLQHGADRPSSMDVQAWKTLHGIDPSLEEGKVPTLITKWDCSARAIIILCLNDSNLKMVKSKSLSAKNIWEKLKQHHEGNANPFKIRTLLYEISNVSYDEDTIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N6G5</accession>
    <name>A0A2X0N6G5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C008g05227 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C008g05227</name>
        <name evidence="2" type="ORF">BQ5605_C008G05227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N6G5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY79806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="505" mass="53847" checksum="0A1ACA285CA8F68E" modified="2018-09-12" version="1">MSRVTSVWSEQQQQQQQPQNRRDSSSTSSTSLQSSSTAASRGSFSSSSSGSYSSSSWASWSAATSTGPACYGPRSTTKASLSQVASSGLDLVADTPSTLQYNAPLLSPPTSPESIHAILGGPCPTPPATSSTPSTPAAGPGPTPSRTRDMMSAIIPSITSHNHTPASYTTSPHSTSSSSHHKKSFVPPSIKLNQFFASIESGASAPTTTPAPAAKAVCGGGGRSGGVAGLVGSSGNKFKGLAGGVANSAKGKMAQVKKAKALNAQKVKADKVAAAQAAQAEAEQAARRRQQQQVTYEDEYDFEDERYFDDEYDDEDDYTSSGDEGDLESEGSGSYNAGSASWSTDAQQPHPPHPPHLAALSADTTYTFKPLPTLPQYKGSRESVDSDEDVVAHVEYATERDFVESTSARVSAHEEDPDHPAAKYAHQSRYSSDSEVEPDDRDRDDEYRGRSRRPRLLWRSQLAEPTVSVLDQYCREYYAMELPRLKGKGSPEGRKWSRQLDQAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N7F7</accession>
    <name>A0A2X0N7F7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C023g09675 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C023g09675</name>
        <name evidence="1" type="ORF">BQ5605_C023G09675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ23985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N7F7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ23985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="179" mass="20175" checksum="FD3C34159D1C0948" modified="2018-09-12" version="1">MRGLINDSFSEVKPRGTRVATPAFPSNVLNLHLCPAAFFPFRHSLQHTNSLERNQENHINLLFRPPSTNTTMRFSLAALILVVSPLLATASPPQVREAADQLRLRFTDENDDKCPDLKVRCFKDGDLTQPIGNIGKQSYCWDEEETKCKQCHQTKNNVQCNTKYLKDCATKCEAIGTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N832</accession>
    <name>A0A2X0N832_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C024g09877 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C024g09877</name>
        <name evidence="1" type="ORF">BQ5605_C024G09877</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ26289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N832"/>
    <dbReference type="STRING" id="796604.A0A2X0N832"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ26289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="82" mass="9041" checksum="76FB1E762A08CAC6" modified="2018-09-12" version="1">MLRPSASGINGGSRLCLGWQDLARYESAALLATILRDFDFAPSYSEVQMLPTENAPRYASSITLPMLEPLMVVAMPHKRSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N981</accession>
    <name>A0A2X0N981_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C026g10269 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C026g10269</name>
        <name evidence="2" type="ORF">BQ5605_C026G10269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ28069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N981"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ28069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="584" mass="66387" checksum="0A2417687E49F49D" modified="2018-09-12" version="1">MKEIFDLTETLSQTWYEATNGKTNTDKTLVLPLGPNWLRDETAQALPTVQEGESFKWCGYAFFRHSDSKLFWTHVLDRIKAKARAARDRTLLPSGRVFYANAHITSTVLHVLSFDIPPQWFIQAAETALTNFAREDGGLGLISIGDIVHSVALRFWDAVAGSDEAIWAPLARESWRKAAIGYLIRSVHLFSEAWRCAPTVVFSPRLDYTLVRYSLIATTHDFSPWGFFSSTARVEKLYRDSTRWGAVIAAARVTLPTIKSELLTLPKLLSLLPRLPSLYAEGAKHAYDDADAVAKFAQIADLYWRDEGKGWALHVWARVGQKLKAKALLPKTAVRPARIPLKEDLHPRCFNFFGLTQPFTIRKLRRLVNTVWFPGKDGQDRALPGGQPQEPRVKRFPEGTSQSGRQRFWSWLHDRFASAAEQDTHWRLMYNVTLTRKKQHVQGHASSPLCLFCGNDAAVIETVSHYFFGCAYSASYWSGVLRILFDKLGIADTDVDPSTFTQEQLTMGLPLLRGRGRTTSKWMWVRLACAIGFQRLHLLRWHVHQRFEKDRVVAPPSIPSALRAFNRDYLSRAGFVPGARDWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NCN2</accession>
    <name>A0A2X0NCN2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C020g09203 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C020g09203</name>
        <name evidence="2" type="ORF">BQ5605_C020G09203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000082">
        <property type="protein sequence ID" value="SGZ18772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NCN2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ18772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="215" mass="23876" checksum="2F9F5D1B4F62C300" modified="2018-09-12" version="1">MTRPPALDSNADSDPAVDDSEASSFDGGEEAMDRLRQVVNLLGNCAPNHLQLEYDTMQAKRQAIMSSNLLWSAEEKADYGQWPLILGDRRKADEWTLKDTIPILKLPLYMATERNQPEQEHEWTACKYERCLAVIETSHGAPSISFHQHPADHLTFVDDPIIPSPEQNFANCSKADYNPPSSCSQNIVALLTARAEGPIPRVTGGSDRPTIPYAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NGE9</accession>
    <name>A0A2X0NGE9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C056g12670 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C056g12670</name>
        <name evidence="3" type="ORF">BQ5605_C056G12670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000095">
        <property type="protein sequence ID" value="SGZ29471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0NGE9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1268"/>
            <end position="1553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="650"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="711"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1847"/>
            <end position="1872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="713"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ29471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2091" mass="232255" checksum="0580FA1E039DCA87" modified="2018-09-12" version="1">MQTGDPGSAPGARAPPPPASAPTSLPIAGTKETQATQVAGRTATYAAATNSSVVSNETPAQQQDRLARLQALPGILAAIQAVPGNRADRFVQAIFATPDFPSTVATALKFSALNATRNIINPFANALEVSLSHKSTGRASATDKGELVACVRTLLSPNTPICFDTGVPLSGDLEAFMPRITGLQHSSTFRTGVLHHRITVGFVSAEARDAALASAPMLVWNSANARFAKAHPFHRNMLEMRINVGVVRPPSKEQIVAAFQSIVQQLSTKGHSCQLVQVLRVIHVDTAKAYAHTVGDFSAFIHFDDASLFQHPTTTLKEILPSRMDLPTRGLDVTAVRHDYEKEAPCARCHFAGHVERCPLMQAANRKEAEDLARHAVMRGAGMVGGGEQTGVGRAATTTTNNIRPTANNNNTSEVVAPSRALGTDQLESRNRFAGLEVEGGQEDDIEEEVAGKEGEEKEQVEEGDEDTGAKADDEDSDSDGNAGAGIDKAGGDGKDDDKDNDEHDDKDEQDDSSEGSERRGDDVMKDGAEEEDEEMETEVEEEVEQEQGVQDDSIMIIDDGQTTITTVSRESTPRSPSWPPLSPETLAKSLREGAEWDRANAEAAARVQAENEAIINAQLDAQEPLVRHQFAEWGQEDGQLRFINIRGTGSRSNKKMKRSQTVADLSDPSDDPVDVKRVLNRVKGRAGKEVAGQGKRVTRSMSAAAAMQVEGAKAKAEKGKGVEEEKRWSDHEPEDNILPEFPLFEDNITAKSTWNVRRCMGIPEKRRDLYTYLSTFKASAILLQEHFIKPELWQCIKDEYEGKAFISKHCLTLIPADSPLIDAEILRTHSALDGRILVTSFRRRGDIRILEINNLYAPVDTKQRLTFFDKLHFHRTQSTHLRLLGGDLNDCPLPAIDRRNQGRHGHHWPILIGKLDSPYTDCIRFKHPLTPSFTRPNIVRKRPKSFSRLDYFLLQRTHQKRLVQASTIYDHPKDLSDHRPVSIVLVLSDERGDAAEPNNSLPTTSNQLHRINAATFKTAAFQGMLEGWLEGASGEEPVGELEVVLGNCEKEGRELARREHRERVERMAVLVGRVQDLEALPVMGDEETAEWTRTTEELRRAVNERARQLRIRAHVPEIATEERLSRPVHAKLAARSSDSKITALRLPNGELTHDIDVALDHTQAHFQRLYNLEPRDRDHVERLRDDFLAPIRAARTCDDPSSDPLFLRRLSEAHIELLQQPITEDEVVAAIATTHPGRSPGPSGVPYELYHTAPRAWAKALSRAFNAMTERGSLSPRQGQGLVRLLFKHQKIGADRAELSSYRPITLRECDYKLFTKVYVARLNHVLPDLLPPQQHGFVKGRRSADASFHLRLLIEELGARGTEFPDAALLSLDQSSAYDLVEHEWIFAIFDALGAPAAFQRVLRMLYSGDSTTARYIINGFLTPPVRLTCGLGQGDPASSSVWDVVFQPFLDALHRRGIALNLSLPTIHPYPQSRAMTSLAFADDVVVAVAGSESLTLLDDLALDWRLATNGRLNTDKTVVLPIGCRWEAGDRPLVVKAEGESLEWIGLSFDPTGNTELANVNLVARLEAVLDSARDRGLTHHTRAFYVNRYAIPKILHILSADIPPLEVVKELDRILVDFVRGGKRRSCYGKDVVFTPRFKGGLGVMRMQDVVDSVAARVWDVLLGGSDAIWQGLARAAIVRAHPAPDFDLATDAWPCDYTPIRTDLHPRWQAVLKVPSTHNAQVKPRTLTLANLLALPIKLHTLHYLPGAPAVSRSPYDADYAAFANYAKVADLFRRELYPGGGFHLWTPPTDVVVSNSEYDQRGRPQREHIVAWYRHAINRLRFTPIAQPVAAVRINGPPRVRPRSEVRPTTPLESILPHPIDPPQRLPRPALPDQSTQYNLLSMDRPYTIRRVRRVLNAKAFTDTIGFRDSLQPDDLKGFWKGVNSKALTAREREVWFKLVRNFTPTRSLQFHQKHDDSPACLVCGAPKDDREHYFFDCVDSGNVWIAARSVLCDALGLDTIDNTHYTAVQRMFGLPKLKASLRDREGAGRTIEIFTGLILEMISSGRWGMQKWGTRMEGVGRRRIILEERLKLRAGGAWGRRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NGW5</accession>
    <name>A0A2X0NGW5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sister chromatid cohesion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C052g12588</name>
        <name evidence="4" type="ORF">BQ5605_C052G12588</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCC2/Nipped-B family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000099">
        <property type="protein sequence ID" value="SGZ30004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NGW5"/>
    <dbReference type="STRING" id="796604.A0A2X0NGW5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090694">
        <property type="term" value="C:Scc2-Scc4 cohesin loading complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061775">
        <property type="term" value="F:cohesin loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140588">
        <property type="term" value="P:chromatin looping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034087">
        <property type="term" value="P:establishment of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071169">
        <property type="term" value="P:establishment of protein localization to chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024986">
        <property type="entry name" value="Nipped-B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033031">
        <property type="entry name" value="Scc2/Nipped-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704:SF18">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN DELANGIN SCC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12830">
        <property type="entry name" value="Nipped-B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Sister chromatid cohesion C-terminal" evidence="3">
        <location>
            <begin position="390"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="601"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU364107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ30004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="763" mass="82103" checksum="94808D09F3AD8B14" modified="2018-09-12" version="1">MAITGGENRDRAPPVDEVLRIVLARHRDKTSTTTAAVAATATSTATNASTTTPLERLRDITESLIDGLLEDEEGSRNIVACVKTVHVLVSVDASLLSTSKATILLPFLKSATSPQEQIVSDYLLKIFRSAVTTMPKTSTKFAKDLQSALMPMLNKPSSSATTLQEVVACYCAVVRGQTHDFGAMINVFRVSVERLLATVKILMAMAAGGGAAAVVGPTKGDPTKALPILCFLSSLFCEHANLDQLRIQYPRKSETKAQINQITPKSISEHVYGILVKLHQLQISPVVSAAALSSLGFLFRAYPTLMLLPPSTSIMDAIFASPAQQTQLQLLKIMQDFLGSQARAGGPTTAAAPLLVGASKRAAAAAKAHGAVKIEELVGNVDGFADSGVASAISQRYIDQILASTLSTNGAIQRVGVELLTAVAHSGFSHPLTIAPHLVALTTSPDAQTLSQAHATLSLLYQKHASLLSTRFLEPAKVAFTFSRSNARGANQSQRITGYRGDPPVSHFGRWYGLLQKEKRVVQLDFLKTLTRALEVEPGASCSDDDVAFVRYIAEALSTLDYKRYEEPLSVIAHLNSALAVSGLQVLHLLEADLDEGAGWLDDEAPSSMPPEGTDGQQLPATSKGDRIAPAPSPDLARQSVRCGIALLLRDHLKTLYSITDAKLSKYAPGKKSALGDRVRDLIFCVWGRKMCSCFFAQAVNRRAEAPLALGSDEYARMPFALTPMSTPAELIQQRHEYIRMIQEDETITTLDESEMEGEDMNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NNY1</accession>
    <name>A0A2X0NNY1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Double-strand break repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">BQ5605_C013g07313</name>
        <name evidence="21" type="ORF">BQ5605_C013G07313</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR. It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation, which is required for single-strand invasion and recombination.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16 18">Belongs to the MRE11/RAD32 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NNY1"/>
    <dbReference type="STRING" id="796604.A0A2X0NNY1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097552">
        <property type="term" value="P:mitochondrial double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000011">
        <property type="entry name" value="Double-strand break repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.110">
        <property type="entry name" value="Mre11, capping domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003701">
        <property type="entry name" value="Mre11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038487">
        <property type="entry name" value="Mre11_capping_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007281">
        <property type="entry name" value="Mre11_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00583">
        <property type="entry name" value="mre11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139:SF1">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04152">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000882">
        <property type="entry name" value="DSB_repair_MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01347">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 16 18" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 16 18" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 16 18" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11 16 18" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10 16 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 16 18" id="KW-0464">Manganese</keyword>
    <keyword evidence="15 16 18" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 16 18" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14 16 18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mre11 DNA-binding" evidence="20">
        <location>
            <begin position="338"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="576"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="595"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="620"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="647"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="710"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="17">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000882-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="SGY15283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="734" mass="80709" checksum="1D370F61FC79D458" modified="2018-09-12" version="1">MSSPEPGANSGSGDDANGHSQRLNPPRLTQAVEPDRCIKVLLATDNHVGYAENDPVRGRDSINSFREILELAVANDVDLLLLAGDLFHENRPSRTSLYQVISSLREFTQGRRPIELDIVSDAGIGIRRDATWPSINYLDENINVGLPVFSIHGNHDDPQGTGAEGALCALDILSASGLINYFGRTEIPGASANDEDVQEDGGIVIKPILLQKGSTKLALYGIGNVRDDRFHYEMKNSRVEMHQPVEDADEWFNIVLVHQNRVAHGKKSNNTSDGAFSDDAHLIVWGHEHDCIEQATPVSVPGRPYYIVQPGSSVATSLAKGEAIPKHVSLIKIQGKEFEFEPIRLRTVRPFIFEDISLSEAHDPSRKVNLKDKVAVNRYLKGRVNDLIARANAEWAELNPDLPASERLLPLIRIRVDYGGGPDGNGVFEIGNPQRFGQDFVDKVANPRDIVQFHRKAARASKKVDMDHVDKAKVMAAIEESEDIGSQMEKLKVSSLVTQYLSAQNLGVLSEEFMQRAIEEYVDKGDRDAIADMLKKSVKDAVANISKTYIPSKDGPEHDHLENEALVAKDYLTAKYAPKPNKSKGKQKRSQDSDTPQEEEEEEERDSMADSAASSDDGRRGRKKAAPPAKKKGRAMSSRKKQNELFLSDDDDDDDDDVVVQDQDDDEESDVISDSPPPKKAPAKKVAASTRKTVAPAKTKAVPLPKPKAKAPAATQPKRAVTQQVVSTDSDDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NRZ7</accession>
    <name>A0A2X0NRZ7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C014g07706 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C014g07706</name>
        <name evidence="1" type="ORF">BQ5605_C014G07706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY19621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NRZ7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY19621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="154" mass="17115" checksum="60E790A7FA026D1C" modified="2018-09-12" version="1">MAFGEPNIVLKTVVLIESSGASTLTSTRSIPTSALTGRRISLASSLPPEFVKLIGFDRLVWPSIRTFLIARTEPNVALYVIECLEKPALFQVSLYFDQMGAFVYRRYFTTDAHVPTRTALITAATQANDMIQAPCLIRLWYLPVPQEKATFSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NV91</accession>
    <name>A0A2X0NV91_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01014 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01014</name>
        <name evidence="2" type="ORF">BQ5605_C002G01014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY29101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NV91"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY29101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="95" mass="10532" checksum="04A1D64A832A5B01" modified="2018-09-12" version="1">MMETAWDRDLESGSRAGTFQIFSEHAGKLIPPLRTQQRTQQLVVMYPQNMSERKVTKVCSLFHALQSGVSLRSSKQTSAVTAVRQPPGRARGSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NVT6</accession>
    <name>A0A2X0NVT6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C012g07020 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C012g07020</name>
        <name evidence="3" type="ORF">BQ5605_C012G07020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NVT6"/>
    <dbReference type="STRING" id="796604.A0A2X0NVT6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="409"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY16890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="429" mass="46525" checksum="371074B82B2F57D0" modified="2018-09-12" version="1">MHHASGHVPPPVQFTKQTLKGRRAACTTMYSYPSSASSVPVLEDVVFRWDSTCYNFTKIDLYLSVQSLANGLVPVHCWTQIDFGTGTTKVRLNPTWWNASSNGGDPITAELGMTASGSPLWNTPASSSPAFTITNIYNASNTDAPATEAAANGSPTVGINHSDSLDGGLAGGRLAAAVATPLVALMVAVCAYLAWHKFYRKRGDTKRWSAVSSSSRLALDYWPRLAHSAWNDVQVIDKRVSMMSEGTWQPSASIVSRPESFRSRNRHSASSYGNLEGAQRGSIIRPSSTYSSEHASPPSQPVDRSSRISFASIPELSRREGYDKLPGQSHHHGRTRSDMGPLCTRRDLTQMSSSPSDGALNPRLTGMNVYKSSLRHEVLLSDPIKVESCEEDVRPSGPVRPLGEDLAHSYSSESDNSTDSIPEPTDRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NWX7</accession>
    <name>A0A2X0NWX7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01694 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01694</name>
        <name evidence="2" type="ORF">BQ5605_C002G01694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY34873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NWX7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38645">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38645:SF1">
        <property type="entry name" value="YALI0F12243P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY34873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="392" mass="40150" checksum="DCFF51C88A4654B0" modified="2018-09-12" version="1">MDSLGGLSDTLPRGSAMEATEKELQTAFRQSALALTGLFKVGKKATRRAYSAGKKEALQDVLEFLQASLDHPLVHGEASSLSGPPGQLNVARLIDYICARQETLQAEEEGDQDEEEASSAPAPQHPTNQSTSNQHSRPSAGGGSRSASSLFASRSSAAASTAVSTSASTPAPLRPQSAPPSRSTIATSPIVSTSAPSSPPFSTSTAPQFRNHPAPFAAQRPSLFSQSSATASTPSSPLASGSMTPTSTSGSGSGTVTRRRSNICSGANPNSARRNASGRSSSSTSGSRDRNLDASAGSPSASSSSTVVDAALGSSVGAMKRRFHTVSVADLVDLERQQESGTAAVVLAKPAASAEGGELDAHPGDGSEDIDMEMDGWDGVGERPPKRVLRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P0P8</accession>
    <name>A0A2X0P0P8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C001g00731 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C001g00731</name>
        <name evidence="3" type="ORF">BQ5605_C001G00731</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY49042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P0P8"/>
    <dbReference type="STRING" id="796604.A0A2X0P0P8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00657">
        <property type="entry name" value="Ferritin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052965">
        <property type="entry name" value="Pigment-catalase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31694">
        <property type="entry name" value="DESICCATION-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31694:SF26">
        <property type="entry name" value="OS05G0151100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13668">
        <property type="entry name" value="Ferritin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015855930" evidence="2">
        <location>
            <begin position="22"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="278"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY49042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="380" mass="41132" checksum="2DA0F274AE818BD2" modified="2018-09-12" version="1">MRSVLALVAIALAVASPMAAAAYPRAGEQSPPHPPAKGKGDHYHHEHKRITKVPKKRQYVKVADLEIMNFALTLELMESSFFSQGVNRFKREDFETWPKMYEHLQSIASQESDHVKALKKALGDHAVSACEYDFGESLNSAEDFVYTSLILETVGASTYLGATPLLSTPELIEASGSILVNEARHGTFLSESLGLNGYSTSFETALNYKQAWTLAYNMIKIDKCAGVKNKLLPDDLNPFPALTIVKPEASKGFPFVVSKGSTLVLQFSGLPVSNDANDAAVPNDANDAAVPNDANDDSAAKAPKGKMAPKSKMAPKEYYAAFLNNGVTTYVPLEPVKSGANWQVQAPTNVRGSTYVMVTTSENSLSNNNTVAGPAIKFFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P2E5</accession>
    <name>A0A2X0P2E5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein HGH1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C002g01758</name>
        <name evidence="6" type="ORF">BQ5605_C002G01758</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HGH1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY35361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P2E5"/>
    <dbReference type="STRING" id="796604.A0A2X0P2E5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039717">
        <property type="entry name" value="Hgh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007206">
        <property type="entry name" value="Protein_HGH1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007205">
        <property type="entry name" value="Protein_HGH1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387:SF9">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04063">
        <property type="entry name" value="DUF383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04064">
        <property type="entry name" value="DUF384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein HGH1 N-terminal" evidence="4">
        <location>
            <begin position="103"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Protein HGH1 C-terminal" evidence="5">
        <location>
            <begin position="324"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="377"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY35361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="451" mass="49506" checksum="1B5E5EFF7DED7A41" modified="2018-09-12" version="1">MTSLQQKQQDAQLIELLGFLTDPQPQVRRIALASLLPYTAADKRERSLFNRDHYIAQIATMCADQELIAHDALSVLINLTSSIIVADRLAKIPGFLTGLVRMIIDENALLSDLACMLLSNLSKLEHVSMQLLGLRVPFNVSNFSKATDEDAQDDERPSKIAKEGETDGIEALELLLEVFLKGEGKRYNPNANYDFLASVFANVSTIPLGRSFLLSTTSPDAEPPLVKLISFTEHPSTIRRGGVASCIKNSAFQKAGHTRLVAPSNDQPPTSGCIDLLPQMLLPLCGPEEFDIDVMDELPDVLQLLPETKKREPDAAIRLILVETLVLLASTRLCREAMRKRGVYAVIRAAHLAETVDKVTESMVRLVNLLMRDEDESTALEEVPDPLEDDKKPDHGFETAPVVGADGNEIKSYGIAESGPVPVAHAPSSVPASMTYEQVDSEDEEEMLLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P4N9</accession>
    <name>A0A2X0P4N9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BQ5605_C003g02451 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C003g02451</name>
        <name evidence="12" type="ORF">BQ5605_C003G02451</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC41A transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY40954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P4N9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="entry name" value="SLC41 divalent cation transporters, integral membrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045349">
        <property type="entry name" value="SLC41A1-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228">
        <property type="entry name" value="DIVALENT CATION TRANSPORTER SOLUTE CARRIER FAMILY 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228:SF7">
        <property type="entry name" value="SLC41A_MGTE INTEGRAL MEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="MgtE membrane domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="456"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="486"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="524"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="11">
        <location>
            <begin position="188"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="11">
        <location>
            <begin position="427"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="94"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY40954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="592" mass="63691" checksum="7E83C2B1C1CBCE5D" modified="2018-09-12" version="1">MVPSLSSTRGSSDETAPAFAAPPPPPPISAPAATLGRHSSSEPASTALKPPPIHPDDEPEIQSLLEKHADHDDDDTNSDDDEADQLAMADAHSSLPGFKALSSRDSSERKQAMTTTDTIPGRHRKSTSSSMDSWNSERQKATLMREMLLQIFPVLLLCMVTALVVGELLERMQQWRVFVRIEELFILIPILLNLKGNLGKFVLPSGCRMNLAARFSTSANIGELDLRPTRRALVLGNLALIQVQALIVSLISGLLAFILGVMSRSGVQHHLQHPVHKLGQAEHLRGGYFEALLVLCVSMLAAGLSSAILGGFMCALVVLCRRLKINPDNLATPLASALGDMVTLVLLGGLSFLFALFMGTLVSTAVFLLLLVAIAVNVVLTFRNTYVQELLTVGWAPLFIAMAISSGSGLVLEAYVNRFEGFALFAPVFTALSGSAAAIFVSRISTALHSSHREPYGLVAFALFALTTPVMWILLPFAWITGVEMSWTFIGAFLVATVVQMVVSLAFAYYIATTLWRLDYDPDVYALPLLSSFLDVTGQLALVAAFTVAGGMGSKVVSGKAVEGIGGTIATTEKVTTIAELGERVFRRWWVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P9F8</accession>
    <name>A0A2X0P9F8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C007g04543 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C007g04543</name>
        <name evidence="2" type="ORF">BQ5605_C007G04543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY61279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P9F8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY61279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="251" mass="26414" checksum="20293255AA4CA7D7" modified="2018-09-12" version="1">MFQPNLPNSAYAHHPMKGVFDFAAPSNSCTVAAPTIVLQSACVDLNSRPNPSAVRLLPVWAAPSLSVVPSWPLPLPSSSPARTVSLEWTMSRTSAVPAPTSSSSSSLPRTRQTQISDHLKAVKTSSSSSSSPRPKQQLAAFAPASSDSVMASTRASAASKSIAAKTRRSARSTRSTPEVESIQCAASAVVEQLPGKAPAAWSGERASPQRPRLQSHQALHEQHTSTDAHSQFLASTSTTKISTRSSGKHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PAA2</accession>
    <name>A0A2X0PAA2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C007g04873 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C007g04873</name>
        <name evidence="2" type="ORF">BQ5605_C007G04873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY64130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PAA2"/>
    <dbReference type="STRING" id="796604.A0A2X0PAA2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY64130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="329" mass="36343" checksum="F01DDA92A4A6446D" modified="2018-09-12" version="1">MSNFSPLLNPIHVPRPTAPSISGFVPSTLTPSYSIRHAHMLRLHDVLLHLLSLAPSRTNSEQCLRAWYLLAQCHQLDLTSLYRLGGLVLARSGVVDTETSSHGHDERDDDDEEDERVKRVARMRAEWYKANLTSGTQRDDATHKIDRLEEFVLALASSGQSALALEELQSYLPAHPYHDSIQLHVLEGQLALLVAQSLSGGPPPHTSSSSSSLAAKRTSSRPHHLDLDSDSSSSSDDLTFSSWLTDGASSLSTPIGDRATYRFLTYVASSSPILYDQAKEAFRQASRLHRKHKSAATLHDEGTRWLNLMTAAEAHQLKRSKQAIDINSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PAH0</accession>
    <name>A0A2X0PAH0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C007g04842 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C007g04842</name>
        <name evidence="7" type="ORF">BQ5605_C007G04842</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY63876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PAH0"/>
    <dbReference type="STRING" id="796604.A0A2X0PAH0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF10">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="6">
        <location>
            <begin position="55"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY63876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="377" mass="41845" checksum="91F7981639DEC1BF" modified="2018-09-12" version="1">MPSVTSSVTQVFETLNLRGKDKTPPASDAGLDSGLQRKPLELSGALNEVKYPRVQLTPAIGVEFAKSVRLSEIRALPQQEQDNVLRDLAITISRNGVVFFQDQFDLKPEDLGRIALRLGELAGKPESSTLHIHPTQELTETGLPLGKISSKPDAEGRQISFADSGLTSKGWHSDVSFEPKPALYTILQMHTLPKTGGDTLWSSNYSAYDRLTPPLQAFLSGLTATHDAWRFREQAAQNGYKLRTAERGSPDNQGGAFRAVHPIVRTNPVTGLNALYVNKTFTTKIDQLSYDESAVLLDYLFRLQHESHDTHVKYHWSKNNVAIWDNSVVNHLATFDFKEYRAGDRAVVVGDRPYFDPAGVSRDAFEAQLEKQVAEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PBK5</accession>
    <name>A0A2X0PBK5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C032g11023 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C032g11023</name>
        <name evidence="3" type="ORF">BQ5605_C032G11023</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000067">
        <property type="protein sequence ID" value="SGZ03825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PBK5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="139"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ03825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="657" mass="73046" checksum="DA416AC6A25552EE" modified="2018-09-12" version="1">MVAGSKRAERNLLSVFCLFPQAPPNPLDAQPPDFSTYREPASAEESPDELDLIGHHSRDESPDEIDFLARHHRAFIATDDDNPEAEAIQPVKSITSDPQTWREAMSSDKREVWAKAATAEFNSMRNDFKVFTIDDRSTVPAGATVVTSKFVWKTKRNALGEITGHKARLVAQGNRQRDGIDFTDTFAPVARFSSIRSLLALAATNGLHVHQADIDKAYLHGNLDHDIWMTAPRGFDLPGDKVLRLQRSIYGLKQAGRIWNRHIDTSLRDLGYTATGTDHCVYSRLDDRQHPHYIALYVDDLLMISPDLAKIERVISGLEQRYGVKRLGPAEYILGIQIRRLDDGSVALSQERYIMDVLARFHFDTTTRGTTVPMTPGLSLTAVPGQATERIRSWYLQAIGSLLYISLGTRPDIAFAVSYLARFANNPGHRHWIAVKHILRYLRATYRDELVYTRGQARITGVVGYSDANWGACVDTSISTMGYVFYIAGSAVSWSSKRQSRVADSTTDAEYLALSHAGKEGIYLSQLLEELHVQPVAPAHIFTDNEAAAAVARDPVRVSGTRHIRLREHFVRDMVNRGNISLSHVGTSDMVADIFTKALGPKVFSTHCYALGLRTRHPRLGSASHSRGGGVKSPLSARQRRLGRRAHPLARPLAVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PC64</accession>
    <name>A0A2X0PC64_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C030g10760 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C030g10760</name>
        <name evidence="1" type="ORF">BQ5605_C030G10760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000069">
        <property type="protein sequence ID" value="SGZ07996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PC64"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ07996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="611" mass="68779" checksum="942D65D1EED1291A" modified="2018-09-12" version="1">MSSTLYVKTGDGVAPPANLISYHSRSDVNQVAILKTGNYHAWEHGLKLVLVNHDLWGIVSLGFSKTEASTLGLGLCTAFEHFNLGRPFLPRHFSRLGRLSQLPPPTSWTTGNTEHCLSMKYVAYHLKLTITDCHLQQYQTLWISPPLVLALCALQCDWPACYNSPARLPDRTVSIPPRLCRLTTSPHGRRRTQQLRRRPTSSLSGRYIPSPKPFRHPLNIFDLLLAPKLLTARQKVLLKQDAKAQSLILNYLDSDNAVTACACTTSNEMWKSLHDNHVGFISDQVRFLTAQLRNLQFSKGKEIVKHFTTLQDLFTRLDELGQSFDDIYKSNLMLDLVTHPAWASTLDNLCRPLAPPAEIIIYTWSKLTLLKLQAWFLPRSTPPVNKLSDILPTPLAACILDVSQGNGGKRGGSKKNQGPKRKPNCVCSRVLNAKAFTNTLGLKGPPQPDDLRSFWKAVNSKALTAREREVWFKLILRFTPTRKLQYQHNHDTSPGGVLCDALGCDMIEDAQYTTLQRLFGLPKLKAKLSKQEGAGRMIKIFTGMVLEMISSGRWRMQKHGTRMEGVERRRVVLEERMKLRAGGARGGFNFPPTTPHTHTPSCFIFQQNTVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PF37</accession>
    <name>A0A2X0PF37_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C009g05640 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C009g05640</name>
        <name evidence="9" type="ORF">BQ5605_C009G05640</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY83497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PF37"/>
    <dbReference type="STRING" id="796604.A0A2X0PF37"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000005">
        <property type="entry name" value="Putative Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF12">
        <property type="entry name" value="CATION DIFFUSION FACILITATOR 1 (AFU_ORTHOLOGUE AFUA_1G14440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="7">
        <location>
            <begin position="179"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="8">
        <location>
            <begin position="389"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY83497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="469" mass="51746" checksum="4D662D7D152B1C68" modified="2018-09-12" version="1">MSVINEHPLAASPAFVPFPSPPLSLSDRQADLNAFEADPAYRGGFLASSLSRNEEADPLLLKSKIQSDEHLTELRSRRKGGKVLDSFYTRQNDHITSLLKPMDKHIQEAAEEEDANRLPVSLLNFKSPSPGATRSWSAHVRAVAAGSKFMLYYLQATPTNSGLRSTCCDVQIKIAIYGSFICNCVLAILQVYAAISSLSLSFFATMIDSVFDPMANLVLLYCHRTAAKVDLVKYPSGGSKFETIGDITYSAVMGAVSVVLVAFSVQDLAKGESDKSIHVPAIIAVGIAFVTKLALFLYCYSLQSKNSQVRVLWEDHRNDLFINGFGLFTNAAGAKIAWWIDPSGALVISFMLILVWGRTIYKLFSYLAGVAAPIKFQQLVIYKAMTFAHGIEMIDSCVVYHAGPNYIVEVDIVMSSETPLWKAHDISQALQDKLEELPKVDRAFVHVDHETSHKPVSVQRLLGKSFLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PFA5</accession>
    <name>A0A2X0PFA5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C009g05730 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C009g05730</name>
        <name evidence="7" type="ORF">BQ5605_C009G05730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY84974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PFA5"/>
    <dbReference type="STRING" id="796604.A0A2X0PFA5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF187">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="518"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="523"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY84974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="539" mass="59489" checksum="7451A0F0F6841853" modified="2018-09-12" version="1">MSSSAAKQWVVRDDELDEATAQQQHVDAEVLHRLKHSADGHHILIPQPDDNPRNPLNWSEGKKWATLIAISFAATSPDYGSATGATTLIPQGIDWGLSPNYVNHSQAGNVFMLGAGGIFAVALSNVYGRLPVAFWMLGLSVIFAVLCAAAPDFKTFFAARILQGFFSAPCQATGLIIVRDIFFFHSQVRKVNIWSGFFILSPYVGPIISAAILSSNSENIKLWHWSFGSYSMLCALAFLGVVLFVDETWYNREIPERNQPLTGGRLARMTGIGRPKGSSTRYTLYEAWYRMFAALIKPPVLAVCISFGLNFAWVVGINTTLPIFLVPLYGFGDKQIALFYFTPVVATILGEAAAHVINPRIQEWTLKRNHGVWKPENRLIVNLMAYPFCLLGLVLIGFAFEHHYHYMLISLAWGIYVFSIMLSTAGYYQYLLDIYPTESGELAAWINFARVIGGFTVSYTIVDFVNSQGAIKAFGIFAGLSTIASLFVPALMYWGPSLREAYPSVGLSIPSKTASFVSSSASGEKDTSSMEKTEMHQIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PGL8</accession>
    <name>A0A2X0PGL8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C038g11671 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C038g11671</name>
        <name evidence="2" type="ORF">BQ5605_C038G11671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000061">
        <property type="protein sequence ID" value="SGY91475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PGL8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY91475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="53" mass="5428" checksum="F18F1BA5B79E6D67" modified="2018-09-12" version="1">MRGKLKNRKGARTGIGPVAGEIARALRQLRASKSPPQGGGLAGARPSPLVPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PHH2</accession>
    <name>A0A2X0PHH2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C032g11028 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C032g11028</name>
        <name evidence="2" type="ORF">BQ5605_C032G11028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000067">
        <property type="protein sequence ID" value="SGZ03898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PHH2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="305"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ03898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="358" mass="38946" checksum="553C132970A9AA48" modified="2018-09-12" version="1">MISPDLAEIERVISGLEQRYRVKHLGPAEYILGIQIRRLADGSIALSQERYIMDVLARHRTDQVMVSAGYRLALIHLGTRPDITFAVSYLARFANNPGQRHWIAVKHVLRYLRATYRNELLYARGETRITGVVGYSDVNWGACVDTSVSTMGYVFYIAGSAVSWSSKRQSRVADSTTDAEYLALSHAGKEGIYLSQLLEELHVQPVAPAHIFTDNKAAAAVARDPVRVTGTRHIRLRKHFVRDMVNRGDISLSHVGTSDMVADIFTKALGPKVFSTHCYALGLCTRHPRLGSASHSRGGGGGGCEESTLSSTEAPRSLRAPASPPPCGGDLGARDCLSEQAPADSGARPLGRPLEVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PIE3</accession>
    <name>A0A2X0PIE3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C030g10855 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C030g10855</name>
        <name evidence="5" type="ORF">BQ5605_C030G10855</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000069">
        <property type="protein sequence ID" value="SGZ09218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PIE3"/>
    <dbReference type="STRING" id="796604.A0A2X0PIE3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23163">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027235">
        <property type="entry name" value="PFD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13303">
        <property type="entry name" value="PREFOLDIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="31"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGZ09218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="126" mass="13696" checksum="BAAD63E0EAC53318" modified="2018-09-12" version="1">MSTATTAPATAKASTSSSSRALTEQEANALFRNKTGELQALASKIGELEREAEEHGLVIETLTEANATTPDRKCFRLVGGILVERTVADVLPALKTQLEQLKGVLGTLLGEYKKKAKWQRDNNIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PJL8</accession>
    <name>A0A2X0PJL8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C020g09145 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C020g09145</name>
        <name evidence="2" type="ORF">BQ5605_C020G09145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000082">
        <property type="protein sequence ID" value="SGZ17825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PJL8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015965255" evidence="1">
        <location>
            <begin position="24"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ17825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="103" mass="11302" checksum="DE45A8DB5A992ABB" modified="2018-09-12" version="1">MNLTQLDLLANFLLCHCALLGAGQSGCGGCVVDTIGIQPLIRSPKFLDDKWIVVVEWERARTVIVEGLQGGGCRLQSGSHFKQLCLAKYVLVRLQCMAFETVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PJR9</accession>
    <name>A0A2X0PJR9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C020g09205 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C020g09205</name>
        <name evidence="3" type="ORF">BQ5605_C020G09205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000082">
        <property type="protein sequence ID" value="SGZ18802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PJR9"/>
    <dbReference type="STRING" id="796604.A0A2X0PJR9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="2">
        <location>
            <begin position="195"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ18802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="395" mass="44581" checksum="DBCECFEFEE278BB1" modified="2018-09-12" version="1">MAYYTRYRELPRYVVDAPSLIGKRTFLPEQTHQTCAKNAPFVSELWIDARIRFNGPSSDDEQQLVIAYRQILPRLDEMMLQENRRAQQFLMARYNLPTQDEFAVILPGDETEHHGDTTSGLQTLPDRHPAVMSLTYPLLLPFGEDWSQDNIPFSQNASASSADRRTRNADGVLQRTHGSGSTTADNPQTGRGGSKHFVADAWALTEQERLRWISTNQKTLRAEEYSSLQASLAEGIDPSEIGKRVILPSSYPRSPRNMVQLYQDAMAIVRAFGAPDLFITMTCNPAWPEIVNALLPGQTASNRPDIVARVFQGKLTAWLHDIYEDHGRPGVFGRVVARVHVIEFQKRGLPHAHILLILHPDDKPKTNEMTNQRRTKTLTDCHSEDSGSRKVSDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PJV8</accession>
    <name>A0A2X0PJV8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C021g09266 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C021g09266</name>
        <name evidence="1" type="ORF">BQ5605_C021G09266</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000083">
        <property type="protein sequence ID" value="SGZ20354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PJV8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ20354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="89" mass="9781" checksum="3AF16D6894975FB4" modified="2018-09-12" version="1">MRYGDDGSVLGSAARSSLNLVANSACTPYSDTVAIYCGCLQGRLRHLKGTWFRLALAPGVQTESGFNQWAGRVRIIVNSMRNLKIDFEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PKC5</accession>
    <name>A0A2X0PKC5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C022g09487 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C022g09487</name>
        <name evidence="1" type="ORF">BQ5605_C022G09487</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PKC5"/>
    <dbReference type="STRING" id="796604.A0A2X0PKC5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13668">
        <property type="entry name" value="Ferritin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ22438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="185" mass="20113" checksum="D824353918D3E1AC" modified="2018-09-12" version="1">MSTAAWLARSAEFIEGIGVGAYQTAIRELSNERLTCAYSAIMAVEARHAAYHAELQGQSGFPVPFETASTYSQAYTAMADFIIFPALYTSTDSQTKSTMGLNFTVPAVPVKKYYAAFLNAGTTFYEPMKKVTTYEPMKGGPPSGYYRVNVPKNYKGVVYIMVTTSSNDLKDSNTVAGPLVAIETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LP20</accession>
    <name>A0A2X0LP20_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C011g06433 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C011g06433</name>
        <name evidence="1" type="ORF">BQ5605_C011G06433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LP20"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY12230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="208" mass="23389" checksum="CF400A60DC998766" modified="2018-09-12" version="1">MPAACNIATNSKANGKLPSRNSLQHVLFECQLSSCFFTRGRIDFVRLRIRVIGTPNVSLHCHCYRWTTARILIVVTNHSRNRLWSRELRLTIPWQILNVLVRWGDHRVGRGSEAMPSCYSTARFGGVTVVLAGDPKQCLPGFRSNAFPLFPSRLLHGMLTSGGKLSNNIVNGKGLSESVPVRSGPTQFFAEPCLYHINIDESFYFQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LQJ0</accession>
    <name>A0A2X0LQJ0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C010g06073 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C010g06073</name>
        <name evidence="1" type="ORF">BQ5605_C010G06073</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LQJ0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY14127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="65" mass="7707" checksum="3698A57F8A836D45" modified="2018-09-12" version="1">MINCPFELTPPKTKKKKLRVLFFHSIWKLCRRRRFSSDLLEPITETEFEGLRASIQESKGRLVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LRZ8</accession>
    <name>A0A2X0LRZ8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C012g06795 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C012g06795</name>
        <name evidence="1" type="ORF">BQ5605_C012G06795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LRZ8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY16179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="264" mass="30168" checksum="287277426F104B4E" modified="2018-09-12" version="1">MVRSFALVKIYGMAREGRSLVSGQYPRVKARLVSLYWIAFLSAPTAQQPALEIQPREDIRRCRGDEIAIYEPQSKQKKKNFTDTIGFRDSLQPDDLKGFWKGVNSKALTAREREVWFKLVRNFTPTRSLQFHQKHDDSPACLVCGAPKDDREHYFFDCVDSGNVWIAARSVLCDALGLDTIDNTHYTAVQRMFGLPKLKASLRDQEGAGRTIEIFTGLVLEMISSGRWGMQKWGTRMEGVVRRRIILEERLKLRAGGAWGRRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LT13</accession>
    <name>A0A2X0LT13_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C011g06661 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C011g06661</name>
        <name evidence="2" type="ORF">BQ5605_C011G06661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LT13"/>
    <dbReference type="STRING" id="796604.A0A2X0LT13"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024338">
        <property type="entry name" value="MID1/Yam8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39142:SF1">
        <property type="entry name" value="AEL197CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39142">
        <property type="entry name" value="MID1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12929">
        <property type="entry name" value="Mid1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY12937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="627" mass="66037" checksum="0CDA08C8EECCFF5D" modified="2018-09-12" version="1">MAGCKTIKTARTRGPVPSWLRGLSLPSLLLAWGIASLFAGTAPPFAGTGAGAGTGAGMGVYAATILLNISSSTTTTILLDDPSTSVFSLPARTMASFAIAAPSDTTTTSSSTTAVQIMLSVCQVPLSLKNADSTTAFAFLASTPTLFISNDSSLTSSPGPNDGVTELALTKAQRKNYAIQAFVDGFTNASFTSTKSGGGIFIGVFAPNSTVSDQWTYSLSVTSSTQGSDSIILEPTAGIRVEGTDSSSALLTARPYPTNSTTPAFAGMIARTSILSTTLASSLCFLQNGLEDVVSSRTINQTTTTRNTAQGYVKTQYLVEGLRNGVNYTAWLVETAADGSRKLYSPNYFATQTSTSCQLIYDVPLCPLVAYAVPSPLSVTPEALISFYSTNFSTYLSAFNRTLSTFPCNDSTGDFSPVSTCQDCLDAYTSWLCAVTFVRCTDAPEGSTVLEKAIWSDLWTLPSTTATGTNGSSSTSLFFNDGKAEWTSTIVRDNPTASRTSSLSSDKLATSFPSLVFNTSFTPERASPFPYAEVLPCLESVCELVGARCPPLMGWACPRAKGGMGKSGYAMLKEVGRGERQVESYGEAQNGGMVKESAEEKKRDSDRFGNVFCNSLGSDMLLAQQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LT26</accession>
    <name>A0A2X0LT26_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C012g07048 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C012g07048</name>
        <name evidence="3" type="ORF">BQ5605_C012G07048</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0LT26"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1260"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="642"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="704"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="705"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY16969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2039" mass="226052" checksum="4FAFC75A7FCADDA1" modified="2018-09-12" version="1">MQTGDPGSAPGARAPPPPASAPTSLPIAGTKETQATQVAGRTATYAAATNSSVVSNETPAQQQDRLARLQALPGILAAIQAVPGNRADRFVQAIFATPDFPSTVATALKFSALNATRNIINPFANALEVSLSHKSTGRASATDKGELVACVRTLLSPNTPICFDTGVPLSGDLEAFMPRITGLQHSSTFRTGVLHHRITVGFVSAEARDAALASAPMLVWNSANARFAKAHPFHRNMLEMRINVGVVRPPSKEQIVAAFQSIVQQLSTKGHSCQLVQVLRVIHVDTAKAYAHTVGDFSAFIHFDDASLFQHPTTTLKEILPSRMDLPTRGLDVTAVRHDYEKEAPCARCHFAGHVERCPLMQAANRKEAEDLARHAVMRGAGMVGGGEQTGVGRAATTTTNNIRPTANNNNTSEVVAPSRALGTDQLESRNRFAGLEVEGGQEDDVEEEDAGKEGEEKEQVEEGDEDTGAKADDEDSDSDGNAGAGIDKAGGDNKDDDKDEQDDSSEGSERRGDDVMKDGAEEEDEEMETEVEEEVEQEQGVQDDSIMIIDDGQTTITTVSRESTPRSPSWPPLSPETLAKSLREGAEWDRANAEAAARVQAENEAIINAQLDAQEPLVRHQFAEWGQEDGQLRFINIRGTGSRSNKKMKRSQTVADLSDPSDDPVDVKRVLNRVKGRAGKEVAGQGKRVTRSMSAAAAMQVEGAKAKAEKGKGVEEEKRWSDHEPEDDILPEFPLFEDNITAKSTWNVRRCMGIPEKRRDIYTYLSTFKASAILLQEHFIKPELWQCIKDEYEGKAFISKHCLTLIPADSPLIDAEILRTHSALDGRILVTSFRLRGDIRILEINNLYAPVDTKQRLTFFDKLHFHRTQSTHLRLLGGDLNDCPLPAIDRRNQGRHGHHWPILIGKLDSPYTDCIRFKHPLTPSFTRPNIVRKRPKSFSRLDYFLLQRTHQKRLVQASTIYDHPKDLSDHRPVSIVLVLSDERGDAAQPNNSLPTTSNQLHRINAATFKTAAFQGMLEGWLEGASGEEPVGELEVVLGNCEKEGRELARREHRERVERMAVLVGRVQDLEALPVMGDEETAEWTRTTEELRRAVNERARQLRIRAHVPEIATEERLSRPVHAKLAARSSDSKITALRLPNGELTHDIDVALDHTQAHFQRLYNLEPRDRDHVERLRDDFLAPIRSARTCDDPSSDPLFLRRLSEAHIELLQQPITEDEVVAAIATTHPGRSPGPSGVPYELYHTAPRAWAKALSRAFNAMTERGSLSPRQGQGLVRLLFKHHKIGADRAELSSYRPITLRECDYKLFTKVYVARLNHVLPDLLPPQQHGFVKGRRSADASFHLRLLIEELGARGTEFPDAALLSLDQSSAYDLVEHEWIFAIFDALGAPATFQRVLRMLYSGDSTTARYIINGFLTPPVRLTCGLGQGDPASSSVWDVVFQPFLDALHRRGIALNLSLPTIHPYPQSRAITSLAFADDVVVAVAGSESLTLLDDLALDWRLATNGRLNTDKTVVLPIGCRWEAGDRPLVVKAEGESLEWIGLSFDPTGNTELANVNLVARLEAVLDSARDRGLTHHTRAFYVNRYAIPKILHILSADIPPLEVVKELDRILVDFVRGGKRRSCYGKDVVFTPRFKGGLGVMRMQDVVDSVAARVWDVLLGGSDAIWQGLARAAIVRTHPAPDFDLATDAWPCDYTPIRTDLHPRWQAVLKVPSTHNAQVKPRTLTLANLLALPIKLHTLHYLPGAPAVSRSPYDADYAAFANYAKVADLFRRELYPGGGFHLWTPPTDVVVSNSEYDQRGRPQREHIVAWYRHAINRLRFTPIAQPVAAVRINGPPRVRPRSEVRPTTPLEPINTIQLLSMDRPYTIRRVRRVLNAKAFTDTIGFRDSLQPDDLKGFWKGVNSKALTAREREVWFKLVRNFTPTRSLQFHQKHDDSPACLVCGAPKDDREHYFFDCVDSGNVWIAARSVLCDALGLDTIDNTHYTAVQTHVRTSEAQGQSARSEGAGRTIEIFTGLVLEMISSGRWGCRSGGRGWRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LTP7</accession>
    <name>A0A2X0LTP7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C014g07495 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C014g07495</name>
        <name evidence="1" type="ORF">BQ5605_C014G07495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY18857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LTP7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY18857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="51" mass="5552" checksum="1F7BDECE3BDBBEA0" modified="2018-09-12" version="1">MQPSACTCQCCASFGFDCVSLKEPRPNLDVPASEVCFLCCLLVSKRHTLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LV57</accession>
    <name>A0A2X0LV57_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C017g08520 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C017g08520</name>
        <name evidence="2" type="ORF">BQ5605_C017G08520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY20195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LV57"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY20195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="527" mass="59027" checksum="8AC73EEBCCF85047" modified="2018-09-12" version="1">MTVFTAPYVLIPSSSTPYPPSQPRGLSTHVSSPSTSRGLLRRLNSLLVKEHLHHPEPRTTLAPVFSLAELTPNHLLGLLEVILATRFDLSAERERDDRGDESWQFVLDDDDDIDDGAGMDDRLDEHKLHDERILRFLILGLQQALETRSLPEPDIETMLDILLADIDSSHRFGGSNSTRSGVRLIQHREHIIAWIVAGLFEIEDRLLDPLDTQLGHYYTTVVDRGEDSSHMVAELGIATTGSSSRGTTSATPTTPRKLLFRDSHTQPPRTMMTSPLKQALTTYLPPSPSPRLETTPRKSIVGLLRRDKQARSTSPSPKSKRHSLETSSLSLMLVRPEMERYDRSRPSASIIGVKMARKRDVSDSVGESDLDLSERTCDCETEGYRETGEGDQTEVECSCCAHMDDGTETQDEPVDAVPIHRLSDRPLDASAQRPNWHLTIPKESNAKLFPPARFVTTPLNRNSPTSSSSSSNEDEYVVNLRRKREREEVEKMKLRSCGLDTDLECARGPSWVTGWSEKELQGVKGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LVK8</accession>
    <name>A0A2X0LVK8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C016g08235 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C016g08235</name>
        <name evidence="2" type="ORF">BQ5605_C016G08235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY21420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LVK8"/>
    <dbReference type="STRING" id="796604.A0A2X0LVK8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14825">
        <property type="entry name" value="TRAPPC2_sedlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY21420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="238" mass="25921" checksum="38C8F4309EA09D06" modified="2018-09-12" version="1">MSYYLVLVGTLDNPLYETYLTSTKSASSTILSVPVVSSGAPATSFSIFGSLPPNPNSNSTSTSNPNKPPPPPPSLPTGTQPTPSQNNNTFVGYGHKSGPQGRHVMQLVAHASLDVVEDVQWTNGAMYVGIIPLFCESSFLAVLILPGHQVPQIDRQVSRMDNLRLDHTGSTESFLTVPIGVKLILLHEVKNDDGIRLFFQETWENYVKTLLNPFHELNSPINSPVFDARVKASAKKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LVL6</accession>
    <name>A0A2X0LVL6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C013g07291 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C013g07291</name>
        <name evidence="10" type="ORF">BQ5605_C013G07291</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGU family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LVL6"/>
    <dbReference type="STRING" id="796604.A0A2X0LVL6"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009600">
        <property type="entry name" value="PIG-U"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN ANCHOR BIOSYNTHESIS CLASS U PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06728">
        <property type="entry name" value="PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="221"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="348"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY15222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="601" mass="66648" checksum="773A6C7676CA667B" modified="2018-09-12" version="1">MPSPRIAAATTHSSVRLWSVLAGGAALRLALSTTSLPEILQDRNELVTPITSFTRCKHSLHWSTLQEGFYLVNTLKQDPYLGGSFHHPPLLLLLSQLVSPKTRPLFAHLAWTATDLVTAYYLARVAQRRSKEAVLKDDEQLWSPSSVAALYVILPLAEHNVPGSFPSFFEQRYCLHPFSIATGLSLSTQVFSHHFVVLALLSAIQGTSFSTLPFFRNAYSAVFAISIASHFSLYPVLLLPPLVVLAHRQNPRSTSIARAAIFASAAFVSHQAVVLGLSYYLAGSWNFFSSVYGVILTIPDLTPNIGISWYFFIEMFDHFRAFFVGVFQIHVLIYVAPLTFAFRSDPMFTLVLMVGIIALFKSYTALGDFALWHAVLALYSELASHITRPLVYFGLTLYALALLPSFHHLWLYSGSGNANFFYASTLVWAIGQGGLLIEVLDAKLKREVVNTLDEQGRELVKKGRWRVLQRVNLVRPSDQSTGKEDEIPTGRKSVPLGSIPSNCNMRWYAEQRTTISSLKTDGLEIIKLPEGNYGHAALAQDTAQVVVTMLGKIVAINPSTGMPPVYLRDADIERVGRPELFSRQIGLELATQAVVHSYGFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LY82</accession>
    <name>A0A2X0LY82_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C002g01276 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C002g01276</name>
        <name evidence="3" type="ORF">BQ5605_C002G01276</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY31912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LY82"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="2">
        <location>
            <begin position="327"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY31912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="480" mass="53730" checksum="4D8C5D7B85218A2F" modified="2018-09-12" version="1">MYQHTVVSAAPACGVGVPIRSHVQALWRAKARKGERAGLESRSNPSSPTFSQGKVQLPPPLRHNPECRQLREGSDSDAKAFRENARSYNNALSFTSLAAHWDQTQVGTLGPPVFRVFGRLYHRLGALIPAVNQRPAFAQTWLIDPAEATDTRLQGPDSAETRIQRSTLTKLESMLRTGNRFVREFASAKARAGWDTAKEWVLRLCLPPGRDRRTHNLPTSSTEMAMIICDSDINTGDRGPQDLILQVHGDRCPGVRPKYQIVSSLHPSAMPLRYPLLFPAEEDSSHLNIPLCAFNQIGPLFAKRPRRGGRGRREWRTHRLTLNLLAYDLHKRDEYFSIPHCTQRGFLAFVMTDTPRSRPIDSTYLQLDQENLRLATGQGIISLTPDQAGCSVILGSTFKNRPRENTQRYQDAMACVVKHGKPSLFITVTCNPEWPEIKAALGPNDQASNRPELIARAFESKLNRLCDDNVFGNKQRAGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LYF4</accession>
    <name>A0A2X0LYF4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C002g01346 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C002g01346</name>
        <name evidence="1" type="ORF">BQ5605_C002G01346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY32299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LYF4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY32299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="154" mass="17465" checksum="D82E9605579DB706" modified="2018-09-12" version="1">MIVRQGKVKRMLEWLSHVCGFSREHLPPERQQPQHLIREIGLELVTSEALATLGMESKLRCLFSEHAATVWNLGNGQSIEVNMPNLTAKPQVVFIHHQLIIPKVVCAVIGKMHKGRIAWENLLDLPDYSRFHADVREGLFTGRKCVEGFPTPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LYV7</accession>
    <name>A0A2X0LYV7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="24">BQ5605_C014g07702 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">BQ5605_C014g07702</name>
        <name evidence="24" type="ORF">BQ5605_C014G07702</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY19614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LYV7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0229">DNA integration</keyword>
    <keyword evidence="18" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="16" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="15" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="16" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="17" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="23">
        <location>
            <begin position="440"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="677"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="701"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="SGY19614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="968" mass="106803" checksum="A03981BD3ED6E4D7" modified="2018-09-12" version="1">MSSVSEPDSHNGAGNCLYLKDIKGYKSWASKGYLNLRGDALWDVVIHSVDSLVADYRSTPRFANRRNELACKFLANALSEEQMGHCEHLDSAKDIWDTLKGIHSLGQSSRTMDLLSVLMQPYTGDIIPFKDIVNTVKIAMIDFKNLSMLVRSLPDQYDSIVGNLASDVDVHMDWNAFYPTMNVELADFVARISTTAPKDYFKSYCSRCKVHGHERGWRLCPSRNDNANVSAPPSDSNSNSNVAAIGVDKTALMTYTFPYSKAMPVFPWIIDSGAKVHCVGDKSVISDFISEPLGISVADQSRVNSPGHGSVTFLTSYGCRITLKKVYYMPGAQCGFISIDRLLESMTYVVGPQSNLIFSIRGKSILRSRPGRGFIMVAAPVQPVLSSSPPLMVAANRLTGTCTLMEAHRKLGHQSPAAIVLAVKSGAITGFILKDEKSTKAPHPLYRVFIDLGFVEHSNHHGDIIYLTIVDQHSTAKGTIVLKDKSAETIIGAWTFQAEAERQTGHKIKRVRSDNGCEFDSSLIRGLFEKQVIIVELTAPYAPEVNGQVERLNGSLMGLVQSMLLDSGLPMRFCRMLSPLQLIKVLLGKKPILTHLQPFGSTVFVHVSKERRTMLSPRSIQGVYVSRHVSFVDTSPRAPSVVTSTQDRVDAPIPVFDPRPPPPEMLPVTPVSPVMTPPIGADQPGGDLDVVPPMDEEDEDHDRPRDFHDAEESLDGEAEVALAPSESYAIVRTGPNPGQFENVDYSNILPAGSRRQPQPPNKILPIITAILVNVLDTPPLFHDNLLYDAYCATVFAEEDIEIPKLRLESDLAMVAELRQFDHHGVFQEVTWHEGIWVLGTIWVYNIKCNANGKSIHFKARLVAQGFAQRPGIDYHDTYAPVARSSTILFLIALAAAQGLHLEQFDFDCAFLNGKMSKDIYVQYPKGWNTKGGYKATTASSWVKVKPLRAKSAAQIKTRRAPNADSNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M086</accession>
    <name>A0A2X0M086_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C016g08212 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C016g08212</name>
        <name evidence="6" type="ORF">BQ5605_C016G08212</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat MORG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY21232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M086"/>
    <dbReference type="STRING" id="796604.A0A2X0M086"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057544">
        <property type="entry name" value="Beta-prop_SPT8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051980">
        <property type="entry name" value="WD_repeat_MORG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842:SF3">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING PROTEIN 83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23798">
        <property type="entry name" value="Beta-prop_SPT8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor spt8 beta-propeller" evidence="5">
        <location>
            <begin position="308"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor spt8 beta-propeller" evidence="5">
        <location>
            <begin position="591"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="250"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="408"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="529"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="498"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="529"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY21232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="762" mass="81495" checksum="6F062C87248AE1E9" modified="2018-09-12" version="1">MAVDTTPQNGSNLSTPINVNNTTEVAEQVDGDKPVLPLDDKPTTSAGPEDSAPIDVDSEHVKMGSGANEKGGEGIAPTVIAPTPTPPPPPPPPREPTPIDLGAPNSAYLEQIHKRRRHYTAPSTSDNQSYAIESLLYVPHSTPIHAFSSSLDCSHLYTGSADGYIRRYSLPASLNPSESAHLGPNYTSSSSVSSPAHASSSVLHTTLGVEVGSSVDGMGVAFGAAHTPLLNTMGRYPVLRGYWENEAPPSLSSSSSSSIAPPPVPPNPSTSSAPDPASPPNWIQDRLWSSRTQGGQSRQIEFGPKSKAWNKSSVVYSLQVNKEDLWGLSGTAFGTINLFTIRHDQGQIRHVFPSSTSSTTLGHSPSSPISVLNLTQDERRLWSGGWDGQVLEWDMDLGKAVRRFGQGHDAQVSSVQARPVETGGGRGGGDGDEDEDEDEGAMEVDDSEEEEEEKQRKKRKTGNGDQRKTNGNGNGTKETPTTDGEEEEEDRASTTTQAKEEATAKKDDVDAEGDLDADGEDFDEEALLGVSSNANTTSATNPSSSSSTKITIPIKPKSTGSSLLVPKLKKTTSIPIWGTQPDASSSMRGKKSDDVFMSTSLDGQVLIWDTRVKDANVVRLPSSGRYGMWCASATWSPDGNQIYVGRHDPLVDIYDLRQCSPRSPTLQTLRLPLASGPVTAIKALGTSGRKLITASFDNVRMWDLGEEGGEGKVKSRLVLGHYGGVVSNLWIDPLERYMITTSGNRGWDGTSTNLMIVHEIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-10-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M0Q4</accession>
    <name>A0A2X0M0Q4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C003g02065 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C003g02065</name>
        <name evidence="3" type="ORF">BQ5605_C003G02065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY38731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M0Q4"/>
    <dbReference type="STRING" id="796604.A0A2X0M0Q4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38052:SF1">
        <property type="entry name" value="ABM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38052">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016044505" evidence="1">
        <location>
            <begin position="18"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="ABM" evidence="2">
        <location>
            <begin position="16"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY38731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="105" mass="11790" checksum="0AA8872CB8FBC01B" modified="2018-09-12" version="1">MVLCILVSIALNSESSAEEVKSRLVEFAQSYRSDQGTLDWHVMQNPKIYVQDKTKFAIVERYTDGKAIKTHTANPLYAKFGKWIAPLVASPPVITVYTELESAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M1X0</accession>
    <name>A0A2X0M1X0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C003g02545</name>
        <name evidence="8" type="ORF">BQ5605_C003G02545</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="7">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">cis-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAPP small subunits family. TRAPPC4 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY41728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M1X0"/>
    <dbReference type="STRING" id="796604.A0A2X0M1X0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14856">
        <property type="entry name" value="TRAPPC4_synbindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.70:FF:000007">
        <property type="entry name" value="Putative sybindin-like family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF15">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY41728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="139" mass="15435" checksum="18230FDFD51251AF" modified="2018-09-12" version="1">MSSHSSSTSFLVLIINKAGGLIYQKNYAEGLTPLSSNEYLVLASTFHSIHAIATRISPVPRSSGIDTIEAEAFKMTCLQSPTGTKFVLFTTPSHPHPDLVLRRIYETYAEHLKDPFYTVEMPIRSERFDTKMAAVIRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M2V6</accession>
    <name>A0A2X0M2V6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C001g00250</name>
        <name evidence="10" type="ORF">BQ5605_C001G00250</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY45133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M2V6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08284">
        <property type="entry name" value="RVP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="9">
        <location>
            <begin position="345"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY45133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="839" mass="94458" checksum="6EC7C6714DE33438" modified="2018-09-12" version="1">MNMVRGKKSTAQPAPSSAPEEKEDSSDNEQEGCFSCRHINTDHRASNCTANWQQAPDVPEGWAEFEKKKAKAAKNDTLHHIAENSEDDISTDEENEYAPQFISTIPITLHNDTNSKTLQALADSRASSSFIADKVVEKLGLVVHCLPVPTLVKTAIKGQARAFHVTSFVKILITLENGTWEAGHTILKVAKLQEPLEVVLGFNFLVKHKVTIDFAAHKILVTHPTVPDVKIDLLAPVFGPHPQRGAARNAKQSDKARINWSAVIAYIDGVQQRETELAELRWREAKLRVEFADRFPGDIPPVLMYESPVRHQIELKDGATKPNLKGYRAAHRYREAWKRLIDQHVANGRLRKSSSEFASPAFVISKKGMDKDPSIQPRMVCDYRVLNEGTVHNRTPLPLPDKILSVCSNARFWGKIDMTNSFFQAKMAEDDIRKTTIVTPWGLYEWTVMPMGLCNAPATHQRRVNEALGDLIGSVCFVYLDDITIFADTLEEHERRVRLVLEALRRADLYVSPKKTELFAAECFFLGHQVTREGIKVDPDKQLRGFLGLVQYLRKFIDKLADLTAVLVPLTRKGVHVNEGWTGEHNKAFETIKSLVGNLPSLHPIDHSDKGDPLWLMTDVSNRGIGAALSQGKEWQTAMPAGYWSQQYNPAEGNYAAHEMELLAIVDALHHWRADLLGVRFKILTDHQSLAGFMKQPSLSRRQARWTERLADYDFEIVYVRGPENTVADALSRYSFPEEPTAGRHASDDVNVLAEATLDPAFLRKLRDGYRKDPQCQQAIKNIDSTPGYSVDNGIARFEGRILLPKTGNFREDALHDAHDAAGHFGLHKTYEHLRRNFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M3A3</accession>
    <name>A0A2X0M3A3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01470 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01470</name>
        <name evidence="2" type="ORF">BQ5605_C002G01470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY33255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M3A3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY33255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="54" mass="6125" checksum="CB95BBC3149B4CC5" modified="2018-09-12" version="1">MCTPGSTQPLQGPWPMDQYPCSLDYINYHVNGVEQLQQHQSSPPPGPLWQRSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M5I4</accession>
    <name>A0A2X0M5I4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C003g02282</name>
        <name evidence="9" type="ORF">BQ5605_C003G02282</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Autophagosome membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ATG8 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M5I4"/>
    <dbReference type="STRING" id="796604.A0A2X0M5I4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16128">
        <property type="entry name" value="Ubl_ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004241">
        <property type="entry name" value="Atg8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10969">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02991">
        <property type="entry name" value="ATG8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="lipid moiety-binding region" description="Phosphatidylserine amidated glycine; alternate" evidence="7">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR604241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY39823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="146" mass="17052" checksum="A485D0DB4882A8D6" modified="2018-09-12" version="1">MTRSKFKDEHVFEKRKAEAERIRQKYPDRIPVICEKADKTDIPAIDKKKYLVPADLTVGQVSLVPTARHQRKRTPTEHPYSHQQFVYVIRKRIKLQPEKAIFIFVDEILPPTAALMSSIYEEHKDEDGFLYVTYSGENTFGATHFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M6Q0</accession>
    <name>A0A2X0M6Q0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C001g00419 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C001g00419</name>
        <name evidence="1" type="ORF">BQ5605_C001G00419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY46357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M6Q0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY46357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="63" mass="7291" checksum="DDA2F12528C00A01" modified="2018-09-12" version="1">MQNPSTRFEGVQHRPKLSTSNWSSLKRVLDLILRLAREDGAESRSRINDWIAEQVGNTSYFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M6R2</accession>
    <name>A0A2X0M6R2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00127 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00127</name>
        <name evidence="2" type="ORF">BQ5605_C001G00127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY44193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M6R2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY44193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="341" mass="39319" checksum="DE13AA375FCB1943" modified="2018-09-12" version="1">MEKHKLSNRAVQQRTILSPPAQSPESPTPLERSQANKKSRAIRQQQPTKQTRAIQSKKTRVGSLAKTCVLPKPIHRADKEEPPQSIATPPRRKRSKAVAERNDRMLKCAKKKRTNEFEFYNPILRAKMQARKASELAPLQISIGMTHIQGAVMDHQDLRSQAPSPPDLEAKLWHVKVEEQEDSLKRKREASIIDLQAMDMKDDDTYSVISETPPPVPELARLLHDFECHRRSYHHVKPFTKELTTFFDFYPDHSSLALRFHRYETFLCRLSIQVEAVIKCPASDMDCHQDLIGAAAQNLNYKILDELDYVGYKERCLYYSLFSGKEEDEEEATKPFIKVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M779</accession>
    <name>A0A2X0M779_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C001g00609 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C001g00609</name>
        <name evidence="4" type="ORF">BQ5605_C001G00609</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY48065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M779"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015957638" evidence="3">
        <location>
            <begin position="23"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY48065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="240" mass="24834" checksum="BE06630F628C7C9D" modified="2018-09-12" version="1">MLAYQILWIAFIHTYFGQIAVAASPPLYTCQITAYQTTCVNGPCNIHIRDASSQQDLWTKTNLSSGTYTISWEPNVAAVSHMAAKSCAFSGWSPRAMSKVSVAYALPILLDSDSSGVSANNAATVVNSGSSDCNINGVYFGGDDSDHMGGTGAPFTLPTGNSQDSKDSSEDSSDSEDAHGDSNMNGGHFGNGNLQSSTSSDGSIRESSATSLSSSPSAVLLGSLIVVVVTSMFFGAALLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M8U8</accession>
    <name>A0A2X0M8U8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C001g00868 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C001g00868</name>
        <name evidence="7" type="ORF">BQ5605_C001G00868</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY50287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M8U8"/>
    <dbReference type="STRING" id="796604.A0A2X0M8U8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032378">
        <property type="entry name" value="ZC3H15/TMA46_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681:SF0">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681">
        <property type="entry name" value="ZINC FINGER-CONTAINING PROTEIN P48ZNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16543">
        <property type="entry name" value="DFRP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="158"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="158"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="331"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY50287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="356" mass="40874" checksum="F971BE75117F3707" modified="2018-09-12" version="1">MPDRPRSSPTWYTFGMKNKKGGKGQQKVALLQQQAAQKGRTEEAKEKDRQKAAMAARKAADAQKKDELANLFTPIDIVQPKVPFGVDPKTVLCAFHKAGRCQKGTKCKFSHDLNQDRKQQKASIYADQRDENKETDTMDKWNDEKLQQVVSKKGNPLATTDIVCKHFIDAVETGRYGWFWECPDGGDACKYRHALPPGFVLKSQRKKEEEDSKRKEITLEDFIEVERHKLDQSKLTPITKESFAEWKKNRVSKKEAEAELVRAAKSTTFAQGKATGMSGRDLFSFNPDLGMDSEDEEEEGEEEDWDITLLRIRREREDRLEEMERIRRMGGDFEQMDIKEENENGDAAKEDEKAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M9V7</accession>
    <name>A0A2X0M9V7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C011g06475 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C011g06475</name>
        <name evidence="2" type="ORF">BQ5605_C011G06475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M9V7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47481">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47481:SF22">
        <property type="entry name" value="RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY12348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="377" mass="41263" checksum="DBCC0AD0ED9D81A6" modified="2018-09-12" version="1">MSSTGESDFPNGSGNRLYLKDTQGYKSWSQHAFINLRADKVWDVVNQSIGSLVADYRSTLVIAHATASVPPVEPASSGFSGLGGGSGSAHSDASPRLTSVQVADKVAKYRERAIRRNDLACKYIANSISEEQMSHLIHLTSAYEMWDTLRGLHSHGRPSCTMDLLNALAQPYSGDIPFKEFVNKVKIAMTDFQNLGAPLPHWLFAGMLVRSLPAQYDSIVGNLASDIDIHMDWNTFYPKLLMNVEMADSRNKQKELLSARIVDNTSLVARISTTAQKDYSKSDCLRCKALGHERGWRLCPSRNKDASAPASSDSNSNVAAIGVDESALMTYTFPNSRTMPRFPWIIDSGAKVHCVGDKSVLSDVVSEPLKISVADQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MA42</accession>
    <name>A0A2X0MA42_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g04093 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g04093</name>
        <name evidence="1" type="ORF">BQ5605_C006G04093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY55920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MA42"/>
    <dbReference type="STRING" id="796604.A0A2X0MA42"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY55920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="99" mass="10800" checksum="0C9F6020492A9201" modified="2018-09-12" version="1">MEHQYSPSFWCQPDGEGTEEARCARSLFLIPVARSKARALHARTINSNTGEGSSHRKALLIPSKLALASDACMHGLGIVINGYSAYFALPEGWMDLPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MAF5</accession>
    <name>A0A2X0MAF5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Synaptobrevin homolog YKT6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C005g03312</name>
        <name evidence="13" type="ORF">BQ5605_C005G03312</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY73671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MAF5"/>
    <dbReference type="STRING" id="796604.A0A2X0MAF5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15843">
        <property type="entry name" value="R-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000004">
        <property type="entry name" value="Vesicle-associated membrane protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051097">
        <property type="entry name" value="Synaptobrevin-like_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136">
        <property type="entry name" value="SNARE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136:SF168">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="11">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="107"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGY73671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="200" mass="22345" checksum="5843BAC246DA2931" modified="2018-09-12" version="1">MSLLHALIAPTQTILSKIPPNDSKLTYAAENLLIHYHKANGIVAMVVAQDSAGRRMPFAFLADLFKHFHQKFTYEQIGDAPAFGCNSFENDMSKLMTFYEETPPNDPIKAAQAELAGVKDIMVRNIDAVLSRGERIELLVDKTDQMSNQARAFRKRATVLRRKMWWKNIKVLIAIGLSATLLLYLIAASFCGAKLKCTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MB14</accession>
    <name>A0A2X0MB14_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BQ5605_C007g04766 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C007g04766</name>
        <name evidence="11" type="ORF">BQ5605_C007G04766</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY63019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MB14"/>
    <dbReference type="STRING" id="796604.A0A2X0MB14"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF57">
        <property type="entry name" value="MITOCHONDRIAL SUBSTRATE CARRIER FAMILY PROTEIN L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="35"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="142"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="236"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY63019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="331" mass="35901" checksum="5136A0BEE896A415" modified="2018-09-12" version="1">MSSPPVVLADGNDPPPPDAVDTSLAAASVVPQSSGVRWKGFVAGIMSGLTKLTIGHPFDSIKVRMQCSELGTYKGPLDCLQRTVKYEGLRALYKGASPPAFGWAASDAILLGSLHNYRLMFARIEGRNRGEDVSVVSEIGRLSLGGHAAAGAMAGWTVCTFITPFEHLKAKLQMQTVGPKLYTGPIDCARQIVKANGVTGLWRGFGGTLLFRSFCSYEILMRKFRDVPIDSPYRVSEGTANFLAGGLSSNVFWIGAFPFDAVKNRLMTDSPTNPRYPSWKAAARQIWAEGGVRAVYRGFVPCLLRAFPTNASALFVWETSMRLLGAEQLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MB71</accession>
    <name>A0A2X0MB71_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C005g03542 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C005g03542</name>
        <name evidence="2" type="ORF">BQ5605_C005G03542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MB71"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY77016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="408" mass="44907" checksum="459D7E64480AB473" modified="2018-09-12" version="1">MYQHTVVSAAPACGVGVPIRSHVQALWSVSARKGERAGLESRSNPSSPTFSQGKVQLPPPLRHNPECRQLREGSDSEAIALRENARSYNNALSFTSLAALWDQTQVGTLGPPVFRVFGRLYHRLGALIPAVNQCPAFAQTWLINPAEATDTRLEPDGADSHMQRSTLTKLESGHRCPDGRPKYQVVSSLHPSAMPLRYPTLFAAEENSSHLNTPLCGFHQAGPPIARNREQIDNGVQLREVLPVSVWMTNEEDKDRDDEDEDREEGDEEDGDGERQRSSKGVEVASLAFTILCALLAKGNEYFSIPHCTHGPFLESVIYGYTPSRDRSTLHIRLHQENLHLTTTQGINGLAPNPIGRCTGAAKACNRPDLIARVFEAKSGNKRHAGCFGDECKMNGFCFFAVLRVVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MCK6</accession>
    <name>A0A2X0MCK6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C007g04855 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C007g04855</name>
        <name evidence="1" type="ORF">BQ5605_C007G04855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY63969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MCK6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY63969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="128" mass="13754" checksum="D0E2683CCB20787C" modified="2018-09-12" version="1">MELTATARGLQAPSVSHVFQCWVLLPPVSPGKFKLTSTKGLTRGNVAPAENNVSTGPGCRSDGFISPLRGAIKIVPFFCLPEVHGAGNRLYLKDTKGYKSWASKAYLNLRGDALWDVVIHSVDSLVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MDC6</accession>
    <name>A0A2X0MDC6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C012g06767 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C012g06767</name>
        <name evidence="3" type="ORF">BQ5605_C012G06767</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MDC6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY16124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="247" mass="27365" checksum="A536FA9E4EDC6766" modified="2018-09-12" version="1">MIPEKFWPGVPATSTTHRSIWKKKRCWAILFFVVAGVTFAVALSARAYEDARKNAKENHRIGMALCDQYPTLPYCLKIKDEVDPYNGTLRYVYVVVSINHTTASLSNDTTAAPSNSTGPSLIHSSSTPSNTGMPSSPSRVIRSSKPLRSTSDVTTRTLPSVSIDGTSRRDNNVQLIDEYDSIYENILPYALIPSAILRERSDLLQEDETLWVHNFSFTIDVTNHNATLEGPMTKGYCGFGLGVPMNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MDH3</accession>
    <name>A0A2X0MDH3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mitochondrial import inner membrane translocase subunit Tim21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C004g02977</name>
        <name evidence="11" type="ORF">BQ5605_C004G02977</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TIM21 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY69214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MDH3"/>
    <dbReference type="STRING" id="796604.A0A2X0MDH3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.320">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit Tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013261">
        <property type="entry name" value="Tim21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038552">
        <property type="entry name" value="Tim21_IMS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032:SF6">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08294">
        <property type="entry name" value="TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="47"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY69214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="389" mass="42740" checksum="B37735881A347C28" modified="2018-09-12" version="1">MAAQLTSHLVKRLTSHHHHHHPTRLPSLALALPALAPFAPLGLRCASSSSSSSPSADPHPYLSQLGGRGSNPTTYGSGSTAGPHLGPFPLPHDSREAQMRAAKAKWAELGTGEKIGVVSVWTGSGVVVLVGGVLAVVVLWSTGSELWSEASPTRIFEDATERVKQSSELQSVLIEPFSFHGANSSNRLRRNRRISHQLSTDPQTGQDLMRIRFWVQAHDPIMDQEAWWPWIKRFVSVAIWQDSTRPEAFVTRDEKRAELEEMKNLQVEKENKPVGWGQWAVGGISSALKGLVPRTSTALNTAQNGTSGAALFKRARKPDLGEWSTAEVVAELKKDPTTGAFVYQSLTAFVPDTRHPNKYRIDVPTADLSEPTRGLNRLRFWHRTKTVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0ME14</accession>
    <name>A0A2X0ME14_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">BQ5605_C004g03157 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">BQ5605_C004g03157</name>
        <name evidence="18" type="ORF">BQ5605_C004G03157</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY70511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0ME14"/>
    <dbReference type="STRING" id="796604.A0A2X0ME14"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016137637" evidence="16">
        <location>
            <begin position="23"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="17">
        <location>
            <begin position="170"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="325"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="349"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="SGY70511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="360" mass="40092" checksum="EF1178ED085A6BF7" modified="2018-09-12" version="1">MAPLWFLSCSSNFLVWSPLVLRSETYHCLSSDSIDITKDGQAIAHGTRLTTSTVPLLTLHRCLGHLAPSSIQKMIAAGLLDGFGAGYSDKDVEEFVCNACLGSKGHCLPFPDSESHSPERLGLVHSNVLSFPTPSLTGKRYLVTFLDDHSRKLLGIRNRSQKRQTDARLRILRTDNGGEYQSNAFTEFCQSRGIRRQYSIPYTPQQNGRAERVNLSIVEGVLALLADSHLPATFWDEAAAYFVYCKNRCSHSALAKQTPQFVWNGQRTTTTVLHPKLDPKATRVSFTGYDLASKAFRFFDHSTNKVVLGQNATFLDDDFPGLPVNMPVNADDTERQSFPPTRQRLTPPTRTPPPSRRGPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MGD5</accession>
    <name>A0A2X0MGD5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C008g05130 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C008g05130</name>
        <name evidence="2" type="ORF">BQ5605_C008G05130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MGD5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY79434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="53" mass="5733" checksum="2784A5A4B6DB8743" modified="2018-09-12" version="1">MSELRISASGPESLIESTATSIPSDIQFRKNRAPPPCAAWTSSRSLAKSWNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MGX6</accession>
    <name>A0A2X0MGX6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C033g11177 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C033g11177</name>
        <name evidence="2" type="ORF">BQ5605_C033G11177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000066">
        <property type="protein sequence ID" value="SGZ01969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MGX6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016019621" evidence="1">
        <location>
            <begin position="21"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ01969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="95" mass="10127" checksum="6286C4C58B4C5344" modified="2018-09-12" version="1">MRAMYLSLITFALTITVVRGADSDGNSTCTPENCPSGNCDGNNCLAPNVSGCGACDNAIQHCYGLCNQPQTCPIQCRAHCDSIKRLCRHDQGCDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MGY2</accession>
    <name>A0A2X0MGY2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C016g08057 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C016g08057</name>
        <name evidence="2" type="ORF">BQ5605_C016G08057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY20454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MGY2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY20454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="281" mass="31295" checksum="23FF942DD5518F01" modified="2018-09-12" version="1">MFLENIRDGQGIWRSKRSLYDQSETFAAEYNKSGRTNRVVNEDCRSAALKCTYKAYGLDPERLPAAAAEKATLHLQNTRWAAKELRCGAGTGRSNLDQCAFEPEEDLQNNLLYEILVQISAGIMRDRSAALQWPVRGLDPSNDLEDHRELAFALVTHAYAGLIPPPPNPGSSDRDAKEPKQTCTPQVSTQHQGHVQSILRRRRGEGRGAPYSDAVQLRFTNRVQRSVAVAILGEAPGGAGRGSTSRIVNPEAADLMRMTAQQTFNFEESFFGWFYIYLTAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MH71</accession>
    <name>A0A2X0MH71_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C016g08167 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C016g08167</name>
        <name evidence="3" type="ORF">BQ5605_C016G08167</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY20907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MH71"/>
    <dbReference type="STRING" id="796604.A0A2X0MH71"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF118">
        <property type="entry name" value="BETA-1,2-XYLOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="2">
        <location>
            <begin position="426"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY20907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="728" mass="83084" checksum="54E21E31DC8608DB" modified="2018-09-12" version="1">MFSDNNARRRSSATTRLEVDDRVHSVSRSSRIPSGVASGHSPRLPFSVNDYKSPSVFSSVNEASERNGDHLKAHVGAGGRGGGRSVLGAVELPRKRRALTVLGGLAVGYLLLAASKGTSDLRDEGRMTTTMVPTAFLPIIREGGNVIHRISPAVGSRVKTWHDNQIAAIEAQGEASRKLSEEEHKLRSQHTFHPNGLLLVNENGRHPIYALIERAEQRWSDKLAKQSRTLSEAVHEYKNRYRRNPPKGFDDWWKFCEENDVQLRDEYDQIDKDLLPHRALEPSDSRHRNGVMQERGHTFTMVLEPGRKMAGIKGEYADTRRAREIQDLLSLFADRVSRNLNLTYIIDDNPAVLLPYSERSRMVELAEQGEYWGPSEFVSTDDSHLSNFAQACAPDSPLRRSERGEPYHDYSSDTRKTFVWDHPKSVDLCIHPEGRKAHGHLMQQGVPPGPLVPLLTFAKTSMQADILVTPMEQWAENYKEYEPPWEGKSENKLLWRGSTTGAEFDRHTPWRNSQRARLHMMSQYMDGSKEVLWATDDKMHRGNFTIEDMNHLYMDTFFSGQPAQCDPETCEWLRKNFHFKPTIGIEESNTYKYLVDVDGNGWSGRFHRLMSTRSVVLKATAFPEWYHERIEPWVHYVPVKLDYSDLYDTMTFFVGTPQGKGAHDALAQKIGAAGQKWAATHWRKADMAAYMYRLVLEYSRILALDLEDSVDYVEEPTFLVEPDEPSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHS3</accession>
    <name>A0A2X0MHS3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">BQ5605_C031g10948 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">BQ5605_C031g10948</name>
        <name evidence="15" type="ORF">BQ5605_C031G10948</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000068">
        <property type="protein sequence ID" value="SGZ06497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHS3"/>
    <dbReference type="STRING" id="796604.A0A2X0MHS3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07543">
        <property type="entry name" value="P-type_ATPase_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000058">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000071">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057255">
        <property type="entry name" value="2TM_P5A-ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047820">
        <property type="entry name" value="P5A-type_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF7">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE HELIX TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23143">
        <property type="entry name" value="2TM_P5A-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="995"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1021"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1060"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1140"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1180"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="domain" description="P5A-ATPase transmembrane helical hairpin" evidence="14">
        <location>
            <begin position="38"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="13">
        <location>
            <begin position="277"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SGZ06497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1244" mass="138263" checksum="9A4254C0E65C0232" modified="2018-09-12" version="1">MATQPASTTVSSKNAPFGSGLVPVDSPDVATLTLVQPLPLWARSYVGPWLLLYPLAAYAFYIKYDTYIQSIEWSFLLSICLFGGHALSFLFTRWSVAFRSRGEARHVTDIDTAQKIKVIPKLHRGKGEIVNLQRTERPGQSPLIYFTYQRDKYLYSPETRSFARISYPCDAKPALSTLQKSTGLSTAAEIDRVQRDYGRNVFDIPVPTFLELLGEHAVAPFFVFQVFCAGLWCLDEYWYYSLFTLFMLIVFECTTVFQRLRTVGEFRSMSITPYAIMVRRENKWIEVQTPDLLPGDLVSIVRSKEDSGVACDLLLLRGSCIVNEAMLSGESTPLLKESVELRPGKEALDIDGVDRNSVLFGGTKVLQATGVDPKDKLAAPDGGCLALVLRTGFGTSQGQLIRTMIFSTETVSANNIESFLFIAFLLVFALAASAYVWVKGVEQDLKRSKLLLDCVIIITSVVPPELPMELTMAVNASLVALSKYSIFCTEPFRIPFAGRVDVCCFDKTGTITGEDLVVEGVAGVDTNDRQKLVPVKETSYETTLTLACAHALVLLDDGVVGDPMEKTTLDALEWNLSAGDKITPLDPTTSRVGGEVHVKRRFQFSSQLKRMSTLSTVIPANGGAAKTLVAVKGAPETLKTMYKSVPEGYEQTYKWYAQRGSRVLALGYKWADSMSKNELNTTSREKVECELEFAGFLVFHCPLKPDAVQTLKDLADSSHRCVMITGDNPLTATHVAREVEIVDRQVLILDVREGGEGEADLSWRTPDESKVIKVNPEEPIDVSLFDEYDICMTGAALRQYADRPESWTQLVQNTWVYARVSPAQKEFILTSLKSLGYITLMAGDGTNDVGALKQANIGVALLNGTEEDLQKILEHQKKERVKKVYEQQLRITSRFKQPPPPVPPLIADLFPDAVAAQKAAAQAVGENRQKGIGTKFDVSAITDQLSNMEDETEVPQIKLGDASVAAPFTSKLANVVAIVNIIRQGRCTLVATIQMYKILALNCLISAWALSVQYLQGIKFGDYQVTITGILISVCFMCISRARPVDKLSRERPLSSIFNVYVVFSILAQFAIHVVAFLYLTQLCETYEPQAGNKIDLEAKFAPNLLNSCIYLISLSQQVSTFAINFQGRPFREGITENSALYYGLLGVAGVAFSGATDFVPEFNRWLQLVEMKSSFRKQLCLVMVLDYGGAWIAEIILKYLFADNHPKAIILKGWERRSKRRAEQKRLLELEEKAKQIKEKKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MI87</accession>
    <name>A0A2X0MI87_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C018g08582 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C018g08582</name>
        <name evidence="8" type="ORF">BQ5605_C018G08582</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY25107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MI87"/>
    <dbReference type="STRING" id="796604.A0A2X0MI87"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428:SF65">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX18, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="OXA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="52"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY25107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="445" mass="49705" checksum="3B8C48186B464432" modified="2018-09-12" version="1">MLPRPLVGLGPSIRSNVRPILPIKKRAFPILLPGPSLVASRAFSLWPSQSNATPSPLPIETLPSPPPPPPRPPTMSELSMPTSLPDPTLWEPLSTLLVSLPATLHLTWPLFLPLLTLLIRSSSMIPLQLWQRRQMRRFATVIRPRLKGVHESLALNLRDSSRRKGLSYEQYEQEYKKASKEATRQMYRSYGFHPRLTMYIGPLINIPLFIFISLILRDACQRALLVLPFSPAHLPLPSSATLTPEILSNLQDLVTSSFLWCPSLCLPDSTMFVPLMVGLATLVNTEVSAKLRRAVMRAGKEVDRIEGRIAGNAVVGLRMGQVGALGTRGLTAAEKRRITVINSRREGNDGTRGLTTQTRTTNGPKEQVQEVVEAEDEEEPRSSRIITNAMRCASVAFIPIAAMAPVAVCLYWLTSNCLTLLTNLTFAYYDRTRERKERLDKILRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJE6</accession>
    <name>A0A2X0MJE6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C029g10666 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C029g10666</name>
        <name evidence="2" type="ORF">BQ5605_C029G10666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ15381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJE6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ15381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="138" mass="14917" checksum="E5A70CE928D19A4E" modified="2018-09-12" version="1">MKRKRKKRNVLTTEGPPHSHFPLGRDKDKSTTAQPPRPSTLQVFAQSQQDAVKVPQNLPLGSPWPLKADFLPVAQATPFLGGAHKLLSFGLAGTATKRAKGGYKATTASSWVKVKPLRAKSAAQIKTRRAPNADSNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJI3</accession>
    <name>A0A2X0MJI3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C033g11136 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C033g11136</name>
        <name evidence="2" type="ORF">BQ5605_C033G11136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000066">
        <property type="protein sequence ID" value="SGZ01293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJI3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ01293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1081" mass="115485" checksum="F1610CC3B8380471" modified="2018-09-12" version="1">MSGVAKDLSAAATPLHNSTNTTGTNISIASSISNRRGSVSTPSKRLSAAVVAAPSADDVRKTFGQETAAPPQQLTATTNASTDRPVSAGAENDVTISSFDAIAMPAARRPPLEVGLGLMLDQSSVTSARTSFEVDSAAQLPTSPPLLSTPAPNASSHVSVKPSTSTGGKAAADVRQLLSELGIDDDVSAAHSVEERPRPSSTPSPTNRAAGPPGWNNSAASSGSNSPPGTSASAMSSLLTRRGDTLPRLSTVTTSSGSTSSPLMIFTGSPNPQTTPRSFSPSCSSRTSVSPTPSPTAHSAYVVPVTARTPTASASASGTSGPMARVGSAVASAAMDRNASGSKSRTSDVHSRHQSLTSACAPVTSSYTSTTPDLGSGLLATLSPANGALSSASAYPASPTTSQRGWKVYDWGSGSSKEKDVFSSPTRTNDENPRKGAKGAPGHPSRTEQLVALPSTLLGLFLAPLYGSPRDHAHYSPTLNASTMPTAKAKRQPLLLRTLLLAYLVFSTVFFGLHLASVITGRPSQPPKRLGPRGDEVRGLQVPLGSRELPLAGAGKFVLGKVGAEWAQKVAEGVRWGKMAIVPAPNVPLDAMADISPESSPFYTVRRVGSGAIANRRPEDNPLTLLTHTYRFAKMHEKIHMDQHDEIVPYAFRATGVPNTQDVTAALYSNEAWLSVLPAFVEAWNGPVSLVFETAHSRTSSLRSDLMKKLAALRQSNDLVRKYVDIHIIGAPVGTSEHMLNRCRERMIERPLARNFHLNLGRFFASTEMVFLVGDARITPSPGLNRRLNGATVRDLVLSRGDAVVVASFAFVRDPYNDPKTFNRPSLHQLRAQLGLPASSKWAGVAHEEFDALAAEHIQMLESTLPLARAEWPTKKASLVTLVNTRSGSPSNPTTARMALFDRRWDPNHGPTNWYLWRKSATDARLLEKPESGGGVGLGVGGRVGGGNDVYRVLDYDLHFAPFVVVSKKGQPWCTERFEEMPAACVYQMYLAGAEMWVLPDEWVFTKEMIEKRADSQNEDPAEKLKNSISSRLYGKFHQEACMHYGREFLSLSMWDSEKAQNCRKTCARTDAFCYLALLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0ML45</accession>
    <name>A0A2X0ML45_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C022g09591 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C022g09591</name>
        <name evidence="1" type="ORF">BQ5605_C022G09591</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ23123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0ML45"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ23123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="52" mass="6049" checksum="3EBC6A1A7E1BD9AD" modified="2018-09-12" version="1">MFAIRPNKNGCYFTHFVEGTVPFHVIDGQQSLYKPQERHRGYNAPKISKIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLF0</accession>
    <name>A0A2X0MLF0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C012g06759 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C012g06759</name>
        <name evidence="2" type="ORF">BQ5605_C012G06759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MLF0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY16102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="121" mass="13011" checksum="A7CC5ACF5AE668B1" modified="2018-09-12" version="1">MSTQPHQLTTSVSSSSMVDSSSRLSSSAESSFSSPLDSLAQTLGSVLPGQDSSSSEDHDSGLNSNGDLEPQRRSSLEESDDALRLYRVGLHHYTRAQFADFKKELETRSSLSRSSAVGGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLS5</accession>
    <name>A0A2X0MLS5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C030g10817 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C030g10817</name>
        <name evidence="3" type="ORF">BQ5605_C030G10817</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000069">
        <property type="protein sequence ID" value="SGZ08807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MLS5"/>
    <dbReference type="STRING" id="796604.A0A2X0MLS5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00072">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051640">
        <property type="entry name" value="GRB10-interact_GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14445:SF36">
        <property type="entry name" value="FI03272P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14445">
        <property type="entry name" value="GRB10 INTERACTING GYF PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00444">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GYF" evidence="2">
        <location>
            <begin position="437"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="633"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="688"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="785"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="907"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1128"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="633"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="646"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="692"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="721"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="788"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="850"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="907"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="929"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1144"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1174"/>
            <end position="1183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ08807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1183" mass="122511" checksum="CFB114CC0EC77EF0" modified="2018-09-12" version="1">MSHAFGPGNAFGAFAPTSITRPRPPRRVNSNGSNKDDTTLSEPTAAAAPPPPAAVARSFSSILSPTTAPISHAKRLAQEHERNALKKPFVYSRDFILSLYDEDKARRRPIDLSPHALATSENPTREAPWALCEFRNGEKEFFATSIHPANTRVRLSHQLRGTDSPAAAAGSPSNTLDLASLGTLPRDRDRNAQSTPSRSSGVAFGSGTSPSASSGAAQDKGLVGALGSSTRRVRGTERTTNPSLGITGGVLSRLGGSTNNGSTSRTTSSEGTGAKEVWQASGRWRRAGESEGEGDKPLGFGPRRHPAAEPSSEPSADIRSSETDALSDAVPATWDEDEPSSEPNDAPAFESQSSESVGPVSSSSASQVTEADLAQHATSILGSLALDSDPIDDPFQSSTSAKNHASSAANGFDAIAPTQTPSNPPGFAPIQPNGGQDLSWLYRDPNGQIQGPFTPSMMVDWNKQGFFSSDLRVKRVGELDFETIESVVRRSGDRETFFLTAQLQPITALPPPLSHAVNGGAWPLGQASPGLGSQRAFGAASPFYEPFGVPAAASPSLAHQSSAFGLASRSTAQTLDPWASSSPSVVSAALAAANQASSAASSWDFGNNGVASPGVNGFGHQLQNHNQFNVFGQPQQQQQQQPQGMHHQSSVFGQSQPGWNGLNGATANAPLAQPLWTSLLPQRSLELDTRSPVRSPMASAAPSPIGPPPAVPSQPQFLAEPVTPSSAPAATPVAPSSVIEAAPATAATPVPAPAPVSHWASIPQPSAEKIELSSKTSATDKILREAQEAAARPKAPAPAPIAQEEQAALAAATPSPAPSAAVTPSKPVSATTAPWVKEETTSSSGPSLREIQEIEARAAEKRKHAARIQAAQANIQAAQRAAALEAAEQLPASTNWGASATSASASATTTTTASSPWSKAKATSSSGKTLKEIQEEEERRKKAALQAQQSAGATSPAVAASRAPGRGYAAVSASTGASKAPAPWTTIAVKASPQAQVPATKTVIPGLPLSAVKNPIKGVTMIPPTLTKSSSVSKTLSGTVTTPARASVARTTTPVYSIDHPPPPSAEFLTWARSALEGLVVPSLDEFIAMLLSFPLEISEDVLEIISDSVYANSSTLDGRRFANEFTARRQTDTTSRYPGLSFSSRGTNSASTGASGGKEAQQGSKEWSVKVAGGKKKKVGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLW2</accession>
    <name>A0A2X0MLW2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C012g06909 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C012g06909</name>
        <name evidence="2" type="ORF">BQ5605_C012G06909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MLW2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY16556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="449" mass="51123" checksum="C0B1F9859D4E9BA4" modified="2018-09-12" version="1">MVSYTYNEDDVRKDTAAQPASADALRTRTATAARSFQSHVDVHQDDDTSSSKYTPSPSLRRKAVLRPIQAMTFFLVWLMSLYVFSPQPVSAEVITGRDSPEYGPLSKSAHLISVMTCHVLEIGCPTKTSSNTTQAFTESRFLVRLAQRLEETHRARAAKRKQDQKKKYGELVHKTTQRVEARLHQANSIFHSLKSLQDVGGDQHKWRQMSSIRGWRMLRYWLKRRRNLDSHILKDIALHIHSLGRKAFRSFPLYFEEIDTLLQQLLNATTSKELSKLMASIDAKFEQLDSILQALLNKVAQGHELSARSSGRAHMLYDRLRREEQRIEASRASLPLLRSVLETTASVFGDDLTFHARRLKNKLALTHHSAHSVITLSRSLEEFRAALVTYKTSVGSYKANVIGYYLASLGLTAKEQARHLGKNMQKLKASVQKFIQASRVAQIQRLLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLY9</accession>
    <name>A0A2X0MLY9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C012g06939 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C012g06939</name>
        <name evidence="3" type="ORF">BQ5605_C012G06939</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NipSnap family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MLY9"/>
    <dbReference type="STRING" id="796604.A0A2X0MLY9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000004">
        <property type="entry name" value="NIPSNAP family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012577">
        <property type="entry name" value="NIPSNAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051557">
        <property type="entry name" value="NipSnap_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017">
        <property type="entry name" value="NIPSNAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017:SF17">
        <property type="entry name" value="PROTEIN NIPSNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07978">
        <property type="entry name" value="NIPSNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIPSNAP" evidence="2">
        <location>
            <begin position="231"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY16651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="331" mass="37362" checksum="83BB2A930BF7DE6A" modified="2018-09-12" version="1">MLGRVTCLKTVPPFSGCSLLALEQASLVSAISNGLRRRQLVFDRSPAPQLIASPPPHIVHRRLLTRNGISDPLGAFSALLHGSPEAKAEGEKAEGQHSKLVGRNRSVHEFQKHKVLPQHVEQYKELIAGYYKGIHESEDFHAKLTGSWEIVVGEVDTFVHIFEYEGLTGFEKTKAQIKASHASLLSPISLGHLEFFNHEILPLIQTRTSQLNQEFAFWQCAEPRTDLGGIVELRTYSLKPGALLEWENQWRVGLEARLRSGHSPLGAWFSQLGELHQVHHMWHYATLEERRATREKAWTIDTWSGTVTKTVKLTEKMHANVLRALPFSPMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MM20</accession>
    <name>A0A2X0MM20_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C012g06969 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C012g06969</name>
        <name evidence="1" type="ORF">BQ5605_C012G06969</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MM20"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY16736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="84" mass="9486" checksum="CC524CCDC519A93F" modified="2018-09-12" version="1">MNPYPNQKIPRFCEAKRFTTQNNSVVINVPSPVKLLRERYPDFPPSIDSGLFGSSPQVPHVKGKRLDHSLADGEARCYNTTVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MMB5</accession>
    <name>A0A2X0MMB5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C029g10600 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C029g10600</name>
        <name evidence="1" type="ORF">BQ5605_C029G10600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ14532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MMB5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ14532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="256" mass="28924" checksum="518DC4EBB4659B2C" modified="2018-09-12" version="1">MAALEKALRYLNQDKPTYVIPTGDAPSWEPSDELVLSKLWPHLDPFGLVGFCVERNLKVSLDEQVNHLLNLYDSDFDATLFRQLACRVPKEKVARVAAALLEIDMDVVSEMIQKSKDTKMYRATTEAKKHINRIIAELQSVGDKIHGTTAQMLDMRNEIRGNVNAFGILGRIKDKFLDQADAVAPKSLTEVPISQRQLRPLLIADFGERAMWVPGADDHMRTLHKRVQTRTVTWAMSSDLNLCIYTPALARSHCLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MMN8</accession>
    <name>A0A2X0MMN8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C026g10137 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C026g10137</name>
        <name evidence="7" type="ORF">BQ5605_C026G10137</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ27597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MMN8"/>
    <dbReference type="STRING" id="796604.A0A2X0MMN8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020708">
        <property type="entry name" value="DNA-dir_RNA_polK_14-18kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028363">
        <property type="entry name" value="RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006111">
        <property type="entry name" value="Rpo6/Rpb6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002208">
        <property type="entry name" value="PRK01099.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500154">
        <property type="entry name" value="RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000778">
        <property type="entry name" value="RpoK/RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="RPB6/omega subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01111">
        <property type="entry name" value="RNA_POL_K_14KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGZ27597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="134" mass="14943" checksum="3673FEEC46824E39" modified="2018-09-12" version="1">MSDAGSYRGEDEDFDQNYDADYNLNESTDFAALESENGVVESGQLPPGLKRPLKPNQERVTTPYMTKYEKARVLGTRALQISMNAPVLVPLQGESDPLMIAMKELAANKIPLVVRRFLPDGSYEDWLCSELLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MN33</accession>
    <name>A0A2X0MN33_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C020g09156 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C020g09156</name>
        <name evidence="3" type="ORF">BQ5605_C020G09156</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000082">
        <property type="protein sequence ID" value="SGZ17981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MN33"/>
    <dbReference type="STRING" id="796604.A0A2X0MN33"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052809">
        <property type="entry name" value="Actin_polarity_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012860">
        <property type="entry name" value="Afi1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28245">
        <property type="entry name" value="ARF3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28245:SF1">
        <property type="entry name" value="ARF3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07792">
        <property type="entry name" value="Afi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08616">
        <property type="entry name" value="SPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="2">
        <location>
            <begin position="85"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="945"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="951"/>
            <end position="968"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ17981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="968" mass="103619" checksum="5964D7B50E0463FE" modified="2018-09-12" version="1">MQSIPQHTPTSSLASTSRGKVAPTSSAEPEVARVSLSSKHPPISHVFLAEFDIDHADRLPSHSSSLNPGTSFEPCSSLFTDFASDFCVPSASPRYRIPYRGSILKHQYPGQSSIDEHLLAEHMLPDGAHDRQEDWTVFYLNQIPPLTISDSSTPPTSETDARSTLGAAGANTSGQKSELLYVMSLVRTKKDATVRRGALVKALAVASHHPYIQVFKPVLLLALEAYFIEPSSAYLARLFHSINSMDMSDVPSLSFDERLVLRATERKDFFEEKWSRSSTAQRHQHSANSSTDTSSIHDHHRDSRAPHHHQHSSITHSTSMGSLTNAEVLDGSGPSPSISSNSISSLALGARTHPPSSADHSSSSAPSADESPYARSRTNTLGSSDDGFKVPFFGGLAHLNGGGASSTATSFSYGAQGDGSRSLTPSAAASVVVANVSRDTHWFDSKITFNSMTIPIRIPLSTFPEEIGDYSLIKLIQTFSSPTSLTPGPLHPHLHTSGSATPPIIVLFNALVTNKRVVFLGHGHAASLVANLVLAACALASGCGAVLGGFVERAFPYTNLTNLDNLENVPGFIAGVCNPAFADRPSWWDVLCNYETGKIVVSKEIRPAAPMRTHATGATGRTATAATLVSAISSDLTGTNGDDGEGRTPSLASAPLGSAVGATGGVAAGSTSVGRVQSYDYDFVDEILSSIASHHGEAAIRARCTDYVQRFVRIASRYEEDVTGTTSIGYPYAPFTTGPVSVLGSGVFFPDETMTTREMSINAGRVEGWCLTNGYTLFKQSFALDCERPMRQIDLSHQLARLRYSRRMQSTEVAAIMRSLAELCRTSEDAVVAVSAGVQAPANGQHGQHGQHGRRQLKGVAAPICLQLLARLPAHMGGLLPLAFGLFHPSTTVRSYTISLFDQINANPTGRKFIQALNAFHRSAYHRLCKENEVDRVAGKLNDTLEAGTSPVAQSQSQLNGRRGSQMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPD2</accession>
    <name>A0A2X0MPD2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C022g09419 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C022g09419</name>
        <name evidence="1" type="ORF">BQ5605_C022G09419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MPD2"/>
    <dbReference type="STRING" id="796604.A0A2X0MPD2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ22039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="277" mass="29567" checksum="A907F09D0CA1BE90" modified="2018-09-12" version="1">MASQAELVRRHHTLSTSSSRLVRLERSRARLALQGVGLSEEDQEYYVPPSPIRGSLWSDVGHDSSDAGGFPTFFSPPSSSSSTATTFGAVGSRHTVAGGDLSYATSHLVDQAHSDEPTANARTAPRGQGQDQWISDHARSFPATTESLSPPSTSTSTAYVPPLAVKPSVVTKKSSFVVLRGAKGDAALSERRTVSAATLPPASPIAQSTRHNVAAHTDPGSTELKHRNSLKAFLDAEGTGGQEDWERGLLDERDREERQLRTGGMQVSLDSARFFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPL8</accession>
    <name>A0A2X0MPL8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C024g09864 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C024g09864</name>
        <name evidence="9" type="ORF">BQ5605_C024G09864</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ26231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MPL8"/>
    <dbReference type="STRING" id="796604.A0A2X0MPL8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045035">
        <property type="entry name" value="YSL-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645:SF0">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="596"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="620"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="392"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="397"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGZ26231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="717" mass="76180" checksum="C8856B8CC7B9DE1F" modified="2018-09-12" version="1">MMSTRPSARPPAERVQAEEEPEFTLRAVVAGLVIGTLLCFTNMYFGLQSGWISMMSLQASLLGFAVFKVLPQSSFFAMRPLSVHENIVLQTTAVATGTLPLAAGLVGVIPALAQLSPSIDGSPPLVLSFVALCAWCFAVAFFGVFLAVPLRRQVIVKEKLVFPSGTATAQIISVLHDVPPPKASAARKRNGYRALGLEEQREEEDPTSGPHSRSVEEEAPLHASAHRKIDQKGWVALSVSFSLSAGFTVSIVGVPEPDVVRRLPQRASLQLLSLCFPVVYAIPIFDVFGHLAHEWLWWFTPSFSYIGQGIIMGLPTTASMNLGMFVSWAILSPLAKTRGWAPGPVSSSVDGSRGWILWPALAVMMVESIFSVSIVAFTQIAGPLRSMLGRSTQGLHEDEDDNGDTEEDDFAPSGSRAEEEADPRLVLGGIVLSCVACVVLVAIVFGQEGIKWWATLIALVLASIFSILGVRALGETDLNPVSAIGKISQLLFTIIQPHNVVANLIAGGISEAGAQQAGDLMQDLKTGHLHKASPKAQFQGQMTGSLASVFVSSGIYVLYRRVYDLPSTNFPVPTAAIWLNLARLVNKGQLPPQSSATMIVFALVFVVLSALKVLGRGRPIAFAIGFINTPSFSIARLIGGLVSFYVTRQTAQRRGNNDTGERANAHLENIGLVIVASGFVLGEGFASVVGLATKSAGLGPVSCWGCGSGGGGYCGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQP2</accession>
    <name>A0A2X0MQP2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C025g10093 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C025g10093</name>
        <name evidence="3" type="ORF">BQ5605_C025G10093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000087">
        <property type="protein sequence ID" value="SGZ27248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1061"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="449"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ27248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1854" mass="203247" checksum="6CA5C8BCE6B921EB" modified="2018-09-12" version="1">MPDPPGAQAPPPDNPLGGNRASDDESLNTLTREPVTGGTANPPAWSTEATQARLDCEKVMQNTFRVLGIVPSGKSTRRLMVLMHDASTPPSQAPLLARAAQRAVRNDAAPASNVIRVIMDGPGSPRGPVQIALRKHFGLAETPFMFARPEGVVLDPEVEKLFSKCVKLNPIVTKATKRFPIARHMYELVFESDQACLEAAAAGPFSHHGKEMVTELPSASPLNHVVQVRFTLPSSSSATPASVLRQSLDDALTLSFGRAGRTQGYTLMQLQRGLAVDPNGDPMAMTEDGFHCAYLRLHADLFQGSTETQKAALNAALPQEIEILGAKYGLRHEFETHYCAVCDRAGHQWGACRKPVSTPATAAPVPGASTSTSTTGFRVAGKNGKHGGPAALNSRASGTNMIQLGPRANPAGAATGNKDDANDDDGGGESVASTEPEGGDTGKETLTRATTGPTKETQTTTAAPVSTPTSPSPSASAPASPLSGGTSEPSATSTTSIASTSPRRLRSSSAPGNRRVTRAGSAMILGASGGDGSGGNSSGVNQVKIIRYLKTLRPAPAAILLQEHHLGYNASREGFESAWPGACIRFTPHVLTLIPDGSPLAGHLLSSTPVVFAGAPRFDGRILRSVFRLEELDVEIINMYAPVQEDDRRDFFGLLHFNAPRPKTLRILAGDLNDCPDVSVDRVSITDRAWTPVSHWQTLLSKIAFNALDTVRHVHSCTPAFTRPHYRGRGEERKICSWSRIDYILVQCSWANRLLSASTLFDAPCSDHRPVVATFALPTSNADAEPPLSLPSTSDFISRLNPTVFDDQDFVASIPGVVDEVYRRLEGTAPLGDVYDAALRAVAVAGHARYRSTRADMRRLRAESQSVMEALEARGEHMNEAERDAYAFAKSRLDQLAVKEAQWLRIRAHVPSVDSREGQSASIRTRLNRRSRQTSIVSLEDVDGTETVDMQEGLGIASRHAQSLFTPDPARGDPTNARRSLLGPIRAAKCYDDDRSDPTFGRRLPRQARVALDEPFTLLEVEAALKKTDSGRSPGPSGIPYELFKALPTYFAPKLLDLFNSIWEGGKMTASLAEGLVRLLPKNKPGANLKSLGAYRPITLRETTYKVLSKVLVARLNGVLGELLPPAQHGFMPSRRSADAGSHLTLLLEKLKSLGTEVFPEGALLSLDQQSAYDRVDHAWIFDVFEAFGFGERFISLLRALYDPETLGVRYLINGFPTELVRLLCGLGQGDPLSCPVWNITFQPFLDALVRRGIALDLQKVWPGGPRAQLTHLAFADDAVVVVESPAALSKLETLSQTWYEATNGKTNTDKTLVLPLGPNWLRDETAQALPTVQEGESFKWCGYAFFRHGDSKLFWTHVLDRIKAKTRAAGDRTLSPSGKVFYANAHIISTVLHVLSFDIPPQWFIKAAETALTDFVWGGAGRNTVARDFVFQAREDGGLGLISIGDIVHSVALRFWDAVAGSNEAIWAPLARESWRSLVAATRDFSPWGFFSSTARVEKLYRDSTRWGAVVAAARVTVPTIKSELLTLPELLSLPPRLPSLYAEGAKHAYDDADAVAKFAQIADLYWRDEGKGWALVGHRRGFWQHSKEPALQHEHVWSRVGQLLKAKALLPKTALRPARIPLKEAPRPRCFNFFGLTRPFTIRKLRRLVNVVRFPGREDRVKRFRDGTSQSDRKRFWRWLHDRFASAVEQDTHWRLMYDVTPTRKRQHTQGHASSPTCLFCGNDAAVIETVSHYFFECAYSTSFWGGVLRILFDKLGIEDTDVDPSTFTPEQLTMGLPLLRGRGRTTSRWMWVRLACAIGFQRLHLLRWRVHQRFELDKVVAPPSLPSALRAFERDFLSRAGFVPGARDWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MR06</accession>
    <name>A0A2X0MR06_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">triacylglycerol lipase</fullName>
            <ecNumber evidence="2">3.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C019g08931</name>
        <name evidence="7" type="ORF">BQ5605_C019G08931</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="2"/>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY23379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MR06"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF1">
        <property type="entry name" value="LIPASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016027628" description="triacylglycerol lipase" evidence="6">
        <location>
            <begin position="30"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY23379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="454" mass="48631" checksum="3CF5F7A1ABA0DA48" modified="2018-09-12" version="1">MVRRLDAVRLLTRLLTSCLGLASVTPACSAPLFGITASSLLGGGASFAHPDKDPFYIPPASIRKDKPGTVYRSRKAANPGSGRTGTQILFRTNDAHHNPTTTVTTIMKNSGSSRQYLVAYNMYQDAAAPQCAPSYCFNTHSVQPFCPDGDGQLNAFMKHNWTVIVTDFEGNNSAFSVGHQAGYQILDGYRAAINFLRLPKDVIIGGSGYSGGAIGTGWSAALHATYAPELNIQALALGGTPTNVTSTMIKVNGGIWAGFAVSGMAGQVVAYPELQPLYARAATKKGADDLSIAKQHCAVWDIVHFAFVDILSTEFQSFGPELLYHPLVAKYLQLSVMGSNATETPKQPSVFMYHSTSDEVIPYESALSTAQSWCRNGAKINFVTEKGFGGHLGTQLSYGSIAYSWLYSQLSGTMAPLTECTFTSAMHLELPIRARAIASVRAGSTNRTVERVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MRF2</accession>
    <name>A0A2X0MRF2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C072g12890 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C072g12890</name>
        <name evidence="3" type="ORF">BQ5605_C072G12890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000123">
        <property type="protein sequence ID" value="SGZ34317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MRF2"/>
    <dbReference type="STRING" id="796604.A0A2X0MRF2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635:SF196">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="364"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="898"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="909"/>
            <end position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ34317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="989" mass="110867" checksum="841BB5C7506B49FD" modified="2018-09-12" version="1">MGRELKKLVVRDEPSPPALLVGGDWNCVESQPLDSENQNGTNYGGQEMRDLDTANNLFDAYRLHHPKGRAMTNRSAPGTCRRLDCIYVSPDWVDLFHDHKIWAPVLKSTHSMVVARFQVPGAIDIGPGKFKLGLHVIEGDATCEYLTSIVRTLYNKALLQTPNDPPAAWTSTKHRLLPELQALARTFARFRRGGSEQERADHSRYGAALRSRLDPSLAGPSSIFIRLRKVQASDLIPSLTVNDVVHSDPDSMLGAASDYFERVYEDRPIDDAALKAIIDGLTSTRLSPADSLKLEEAYPLEEMTKAQAACKSNSLPGPDGLPVEFYRATWPATGPILRDVINSIPTKARQPGPLPRNTAHIHLIHKRGERDQLSNKRPISLINADKRIISQAHNQRLAPLLESLIGPTQRGFVPNRWIGTNIAEVQCLMDPGLPGSTPVSGMLAVMDFEKAYDRLSHPYLDAVLCAVGLGPKARQWYRATYTNQSASIFLNGWLSATFDILLGVRQGDPLAPSLFVLAIEGFACQIRLRVKGIDIAGLQNVRELLFADDACCALHNLSDLDHLNRAIELYERASASKLSNVKSFLYPLGAFRDRSIAPDLGTWRLSDSQFRYLGIQVGVEIAEDAGWEDVKASTIARIHSIPMYDLPYAAKCSIINIYCYTKILYYSRFLPAPKSVVKEIEEAAMLAIHGRASDGTQQRPKVSRSRLCTPLDHGGFGLIDLPRRLAINHAKWVFQLRAPDGCFTRHLFDIRIRLQAPNKPTPFTLSRPAPNQHHCPWIWIWWAYFCHPPPKWDHAVRKTTKLLPARWVRYFEAWALVTTLNPPELSKSQNLEQWATHVMTPSSFVNASKRHQVFIFPPIFPKGHQKVFDLPEQRWNAWWKALRKVRRVHSDTKDTGHLLSLGSLHPGSQVASPTSPHPNNRSTSCVMCLSEAPECLVHLAVGCPFARRLWSALSLTPHPVFVDFLCRRGRFLSDLLEPITKTEFEGLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MRI7</accession>
    <name>A0A2X0MRI7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C001g00692 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C001g00692</name>
        <name evidence="7" type="ORF">BQ5605_C001G00692</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY48775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MRI7"/>
    <dbReference type="STRING" id="796604.A0A2X0MRI7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_uL15_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="6">
        <location>
            <begin position="207"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="53"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY48775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="259" mass="28210" checksum="CFCB8BB62B4DA905" modified="2018-09-12" version="1">MPNCTQHAGGRLSRAQESRQIEAASDGHYEAPAQLASQLLVLVTQVANTMPTRFSKTRKHRGHVSAGHGRVGKHRKHPGGRGLAGGQHHHRTNFDKYHYGYFGKVGMRHFHKNKAALWRPVVNCDKLAVRGMADGEQMGHRTGITWARETRSGEVEDFDTMDGSMTSFNGVITGTSNELNANIYLELIVAQSLIPEAQRKGLSTDSAVVPVVDTLAAGYGKVLAKGRLPAFPIILKARYVSRRAEQKIVEAGGVVSIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MSS0</accession>
    <name>A0A2X0MSS0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C110g13212 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C110g13212</name>
        <name evidence="2" type="ORF">BQ5605_C110G13212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000104">
        <property type="protein sequence ID" value="SGZ30190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MSS0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ30190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="299" mass="32659" checksum="FFB4D6E1CACC1FA4" modified="2018-09-12" version="1">MPSGTRDGPPHTDNVARRVKLELPTLNAGFKSRDNYGGKIAAVHLIREAGCKMEGEGADWYIDCRNKVKALKSWPEFAQEVKARFINEKTGLEAKHAFYNAHQTGTLSDFVATLIAARGQAGSIGGTQVISDELFKDHLLHRCDELLYLRATASPSFDVTKFTMNQLVAYLQSLWEAITLERATTGVRCMGLRNDQVRQEQNNSAAHQTSGRPMAGLDRTPRDKALHEGAASTPGTSLTPAPSRPTPGPRMVAAIREYQESGDSTAFVGISSDSEEDDARWLAFQTDKEDACSFGLEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MSX1</accession>
    <name>A0A2X0MSX1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C048g12370 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C048g12370</name>
        <name evidence="3" type="ORF">BQ5605_C048G12370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000110">
        <property type="protein sequence ID" value="SGZ30466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MSX1"/>
    <dbReference type="STRING" id="796604.A0A2X0MSX1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF73">
        <property type="entry name" value="PROTEIN PDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="287"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ30466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="415" mass="47221" checksum="BBE6B6362E7FD634" modified="2018-09-12" version="1">MVSFPSRNLRIVMVNSPPILNSPPIAPKGTHLLMMSVARSQPPLKPCREESGARAAANEVTMLDLTSSPPKKNANKANPSSPLSTYKGLDFSLDIGAATTAQIIKVLDYQKRHKLTLTATVKYFNNSPNHRDIPIWSQPKLTQWRKEEDEHRALLESGQGSIRRNNSVIHPNLEKALAIWFNQALEQSTTITTDVLRLKGQQTCRQTRVSEFPLCESRHNLRSYKFHGEGEKVDAKTLEEERKRVVDLTNKYDPSDIFNMDKTGLFYTMRPSTGLARNGRNGVKMNKTRITFAFTVNADGPERLPLSIIGSAAKPRSLNKKPASYHNHYYRSNKHAWMTGELYVEWLKARDLELRSKGRKVQLWLDNFSGHTRDVDSITNIGVHYFAPNMTSKIQPFDQGIIANFKAKYRRSFER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MT40</accession>
    <name>A0A2X0MT40_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C049g12442 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C049g12442</name>
        <name evidence="3" type="ORF">BQ5605_C049G12442</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000111">
        <property type="protein sequence ID" value="SGZ30719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MT40"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="217"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ30719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="519" mass="57442" checksum="8874EBD158214AF8" modified="2018-09-12" version="1">MVLQDVSNLLSPSLQANTSLDTRMKTGTLAGPSTSALGPSTIALTDRTAPLALARMKLKDTKQERRVSPRLRKLSGIDVDTDTEIDSRRPAAIGSIETEISFSLDQGLTRADVLVNAEECKDEAKRTSAELERLATEYSQAVPEIAHLRNQLGVAHVSGASTDTHTKQVCLNVRITSIQSEVAHHEAELLVLREGLDCHALRIIELETDLASAFASKEFHEAEIKTMRKTLQELEAGKAERESMIAQLTDQVKHLSERLTETSEEAESLRGELKDAQLRQQLQDEEGRNLIAAQEELEHAYDDAVAQLELWKREHGLLSYTEEEQTGNDIDNSIEEETEDDDAEHPCTDGSETLIDHRQMGSQQNNSGTQEVNEVHLHPAEDVTEEFDLVNVETDLTPPIPPAPSSSRSGGRNTFKSRLNKLVASESTLRAKPSRPPPHALRLFAEKELEDELADLRSQVETSAVPSVSDELTDLCRQFYSIDMAKVSRLHSVQGQIDERLSAIRLAATKLKAVQSFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MT57</accession>
    <name>A0A2X0MT57_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">BQ5605_C046g12242 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">BQ5605_C046g12242</name>
        <name evidence="18" type="ORF">BQ5605_C046G12242</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000112">
        <property type="protein sequence ID" value="SGZ30843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="17">
        <location>
            <begin position="341"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="640"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="694"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1279"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1400"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1528"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="640"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="694"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1405"/>
            <end position="1414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="SGZ30843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1552" mass="169604" checksum="81EDAC6EAD3F1245" modified="2018-09-12" version="1">MDSSPASPLAPRDPSSPESSIGEQIATLQAQLAALQASQPAAAAATPAVTAVPGNAATASKVVFPKHARLDGPKSFTNWLRQLRLALPNQVRGYVLDGVIPPTWTADQLAARDDAAREIIVGSIDSADVSATLDAIPSDNLSAPRIFAALKARFAPDDATRTLELFARLWDFRKMPASVEAYDTWLREYMSIAQEIRDAKTSLNDVLATHVLAMVPSCLDSFRLTFTDEQRNRRDLPELTTLTDGQAIAHGTRVNDGLYLLDADHTKCQHLAFLSRSESPVPLLTLHRCLGHLAPSSIQKMIAAGLLDGFGAGYSDKDVEEFVCNACLGSKGHRLPFPDSESHSPERLGLVHSDVLSFPTPSLTGKRYLVTFLDDHSRKLWAYAIDHKSDVFPIFQTWLAEVELETNARLRILRTDNGGEYRSNAFTEFCKSKGIRRQYSIPYTPQQNGRAERVNLSIVEGVLALLADARLPATFWDEAAAYFVYCKNRCSHSALAKQTPEFVWNGQRTTATALHPFGCTAWLTVAPDLRSKLDPKAARVIFTGYDLASKAFRFFDHSINKIVLGRNATFLDNDFPGLPVTTPVDADDTDRQFVVPADTPAPAVKTRTPLVRSAHMDVSSSLDDSAMSAVDVAPGYTGGSLLNSTDTRSSSSPSLSPFSSPATSSARDPSLNDSDDPLDLLSSNTAVRLNLMDVHRSDDDTPETRAPAVDPVGQPSDDDSPDEIDFLSRHHRAFIATDDDDPTLDAIEPVKSITSDPQTWREAMSSDEHNIWVEAAAAEFTAMRDDFKVFTIEPRSSVPPGATIVTSKFVWKTKRNASGDVTGRKARLVAQGNRQRNGIDFSETFAPVARFSSIRCLLALAAANGYHVHQADIDKAYLHGELDHDIWMTTLRGFDFPSDKVLRLRRSIYGLKQAGRIWNRHIDTSLKNLGYKATGTDHCIYSRIDDRQRPHYIALYVDDLLIVSPHLDEIERVICGLEQRYGVKRLGPAEYILGIQIRRLDDGSIALSQERYIMDVLARFHFDTTTRGTTVPMTPGLSLTAIPGQGTERIRSWYLQAIGSLLYISLGTRPDIAFAVSYLSRFANNPGRRHWIAVKHVLRYLRATYRDELLYARGPAKVTGVVGYSDANWGACVDTSISTMGYVFYLAGAAVSWSSKRQTRVADSTTDAEYLALSHAGKEAIYLTQLLSELHVSPIAAAHIFTDNKAAAAVAHDPVRTSGTRHIRLREHFVRDMVNRGDISLSHVGTADMVADVFTKALGPKIFGTHCFALGLRTRHPRLKSTSRSRGGGSGRPGPGLRHTERGWDLGARSEPGPLAQPRGSLAVDLARAALLLVDRILHPFGCAAWLTVAPELCSKLDPKAVHVLFTGYDLASKAFRFYDTTTKKVTLGRNATFLDTEFPGLRGDSAKPDDDTHFASAPFADPQTTVKSWTPLPQAPLDPMDTQPPDFSTYREPASAEESPDCEESTLRSAQDLGARIEPGASAQDLGARSEPGASAQDLGARSVPGKLGGARLSHCYQCEESTLRSAQDLGARSEPGAPAQDLGAQSEAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MTF3</accession>
    <name>A0A2X0MTF3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C006g04208 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C006g04208</name>
        <name evidence="3" type="ORF">BQ5605_C006G04208</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY57010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MTF3"/>
    <dbReference type="STRING" id="796604.A0A2X0MTF3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11296">
        <property type="entry name" value="O-FucT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="679"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY57010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="728" mass="83846" checksum="38C95E12469F26DD" modified="2018-09-12" version="1">MGKPPANRPNSQLHPLLPLTREQHHRMLTVDVEATRNNNRHHSNNTRSRSTSPSSPTMSITSHSPSSPYTIGSSPRSSSIPSPKEPFGAPPRWSERLSSLPRPSSIVSKSREIIHRPWRLPRWRSGPFALLCLLFLGTFASYATYHLSNPDQFDLGYRSNAEEDHWFKDASSVDLTEEETRDGEYIKPSLKKLKQAVGDEPHFLAKDGIAWYGFNNRRYMLEATMNLARVSHRIPILPSHIWARSCVVDSADCTKHALQHLADRKNAPGFKDEFTWNEDGEAWRLGIEHFIDLPHLRRTYGLFLTQTEYFSLYASSLPPKFKIDLRGYWNPILYNPKGMTTRVLNGTKEFHDKSWVRMDREFMGLGGAPFKGSKSWERKGRKGLEGVDENVVRDLMKEDRTYVWSLEKAIKAMRRRGIGEGKHVAKEEWGRALVRQAGLRELYTFDDSTLMCKTMARPSAEYADPLHLRPFQIEAFENYSNATILAISGQIHDQRKPGATHFSTPYARDQFRNWVIEGIRPPRVYILAAEKIVQEMKRRTKGRLWRSAHLRRGDFVGIAWAPEKDPVRHFGKLKNALGAGIQVLRQRRTKKPGRGALQPLKQEELPFPNDPFYLATDETDPKALAYYRRQGAVLLHDVMGQDELEDVLGWRAKYWDLLALVEQEVLAQSDYFVGSRMSSTTGGALNSRLRRRREKEGREGEGEVFVDARDDNWIFLEEFNEREREDHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MUU9</accession>
    <name>A0A2X0MUU9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C066g12812 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C066g12812</name>
        <name evidence="1" type="ORF">BQ5605_C066G12812</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000134">
        <property type="protein sequence ID" value="SGZ35251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MUU9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ35251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="159" mass="18230" checksum="BFA60160BB8AAF66" modified="2018-09-12" version="1">MDRPYTIRRVRRVLNAKAFTDTIGFRDSLQPDDLKGFWKGVNSKALTAREREVWFKLVRNFTPTRSLQFHQKHDDSPACLVCGAPKDDREHYFFDCVDSGNVWIAARSVLCDALGLDTIDNTNYTAVQRMFGLPKLKASLRDQEGAGRTIEIFTGLSWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MY59</accession>
    <name>A0A2X0MY59_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C005g03574 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C005g03574</name>
        <name evidence="2" type="ORF">BQ5605_C005G03574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MY59"/>
    <dbReference type="STRING" id="796604.A0A2X0MY59"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY77180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="343" mass="37927" checksum="2327E004BE9DDB80" modified="2018-09-12" version="1">MDYSHGTMTTYPTIYDYAYPDVRQGGSSRDGRLVDQSQSGSSLAPAPLLKRTNSVISLPSPPDETMSQGPLAPVVVYLSDEELNDTDLEEGGDDDDDVEASGPIARPQPKRSSSNRMLVDCNPFLVPSRRAIQEEQEKQARIEARPDHPHASPTHQARRKRLQQDKIKLDVGQANKQGLGARTMGRGWDSPSNPFIAREGETAAPTAQRENHKPDKITYVFRGKRVTYDVPLDALLAPEDPEDSPFPDPSPRLLFPSGPTSDDEVESTNPITPPSYSRPTSSFLDALRATTSVKPTDEVKSRSLGLPPTPVTERQRKAPEKTFNTRKEARYGPYKKMATLHEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-11-27" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MZN2</accession>
    <name>A0A2X0MZN2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C006g03910 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C006g03910</name>
        <name evidence="9" type="ORF">BQ5605_C006G03910</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY54783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MZN2"/>
    <dbReference type="STRING" id="796604.A0A2X0MZN2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20266">
        <property type="entry name" value="Complex1_LYR_NDUFA6_LYRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045299">
        <property type="entry name" value="Complex1_LYR_NDUFA6_LYRM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016488">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12964:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12964">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B14 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY54783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="137" mass="15919" checksum="A125F7D0D7C02A8C" modified="2018-09-12" version="1">MTTIPARLARLTTSSTSWNDARFRARSLYRAWHRSGKSSCELAPEIVQLYAVNFPASAVRAKVRQQFERNQLVDDLQTYDVLLLKGQQEYQETMNGWKMESQLLRWFQAEELPARPDNFLDAFYLSRDDGKVVQPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N0S0</accession>
    <name>A0A2X0N0S0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g04283 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g04290 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g04290</name>
        <name evidence="1" type="synonym">BQ5605_C006g04283</name>
        <name evidence="1" type="ORF">BQ5605_C006G04283</name>
        <name evidence="2" type="ORF">BQ5605_C006G04290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY57524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY57619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N0S0"/>
    <dbReference type="STRING" id="796604.A0A2X0N0S0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY57524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY57619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="291" mass="33150" checksum="A72BA350B0BC8476" modified="2018-09-12" version="1">MRKLAIAQTVWDALQVDGHELCISDSLRHLIKGDLFTVLLRMVKDITIDTLLMGFFKDNETNATFETIMTRIAKILNLMPMHALQRRFKDGFQHMNWTGDHTRKLMNILLVVDHVSWVDDDNHIRSIVDDISVIFAILSQIIMYATSLESTEADLENLEFLYAIYMKLLTETFNREQISSRTGQTKNLGFNWPRLHAIGHYAEWTRKWGVAPHSNTPDGERAHIDNAKVHYRSSNKCNADGQIRAGVTRSEVMQALIDVIKISEHTAATGATDVIKIPVRPRRMPDNPAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N0Y9</accession>
    <name>A0A2X0N0Y9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C007g04361 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C007g04361</name>
        <name evidence="2" type="ORF">BQ5605_C007G04361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY59917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N0Y9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="432"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY59917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="458" mass="52795" checksum="DB0C12A1AFDAD3E8" modified="2018-09-12" version="1">MAPRATEGERAWLDIDSHLIDLIRDESGQWRVRCELCNKHYKLPGGYRSLDGPTVAPEHAHEAKRNLKKKSFVYTSARSIRLRSTYRSSVGRQYTRSRTAVVAKVERSPRSFGHLKKRYRRQLQAKLDMLEAPGKADRARHDEWAAERARRLVMEPKDIMTQDPIPEDVENFDYEVREEIDYVMWPVWDEWAGYKGNGRLPRSLLTVLIHWRNVLFDAYDNQKRKRGGGTARVLKEYRTRIQDFDDILARIFTVPVDIAAEHEELRLFSEILSPLYQECQRPLPEDDVRTDEDQEGSDRLLRWIRKAYRPFLGKRVPDDYRDQLESEHRTWQAALRPFATTVLVHVPEPPKPPTDADLEPERKKIWDSWIVECAHMWLALSSKQRDAYCWMRKKGSGGEGAASTSGAREEDAISEHSSATGQHSDHGSAAGSEAESNLSTLSELTSLSELERGLDTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-11-27" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N1E7</accession>
    <name>A0A2X0N1E7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C007g04521 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C007g04521</name>
        <name evidence="2" type="ORF">BQ5605_C007G04521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY61057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N1E7"/>
    <dbReference type="STRING" id="796604.A0A2X0N1E7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044980">
        <property type="entry name" value="NDUFB2_plant/fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36987:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36987">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY61057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="73" mass="7758" checksum="CF24623D13AB5302" modified="2018-09-12" version="1">MAGHAAGPRPAGAFHPHLPGIGYRLGAKLLGASMWFFIFYRARQDGAVLLVSLIRTLPSAVVGLHLTFLPCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N2B7</accession>
    <name>A0A2X0N2B7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C007g04881 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C007g04881</name>
        <name evidence="2" type="ORF">BQ5605_C007G04881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY64194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N2B7"/>
    <dbReference type="STRING" id="796604.A0A2X0N2B7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015916087" evidence="1">
        <location>
            <begin position="28"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY64194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="118" mass="13254" checksum="FC98AD61BA52624E" modified="2018-09-12" version="1">MWTSSIVQAALLFAVIVLYSSPVVAWAFCPFGKTAETMAICSGLCRMRCYDPNSGTSNSTCRNACTGQYHVSRSLNAADECMQQCDRFTKDKKKQGEGKLERKSCQHKCTNWFFPLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N718</accession>
    <name>A0A2X0N718_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C009g05468 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C009g05468</name>
        <name evidence="1" type="ORF">BQ5605_C009G05468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY81139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N718"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY81139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="55" mass="6328" checksum="F261AE32A29E4999" modified="2018-09-12" version="1">MMETAWDRDLESASGRTQQLVFMYPQYMSERKVTEICSLFHALQAGVSPRSSKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NG39</accession>
    <name>A0A2X0NG39_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C027g10402 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C027g10402</name>
        <name evidence="2" type="ORF">BQ5605_C027G10402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NG39"/>
    <dbReference type="STRING" id="796604.A0A2X0NG39"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ28666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="162" mass="18204" checksum="BEC39D141787C2A5" modified="2018-09-12" version="1">MVMVNLLAYDLHKRDEYFSIPHCTQRGFLAFVMTDTPRSRPIDSTYLQLDQENLRLATGQGIISLTPDQAGCSVILGSTFKNRPRENTQRYQDAMACVVKHGKPSLFITVTCNPEWPEIKAALGPNDQASNRPELIARAFESKLNRLCDDNVFGNKQRAGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NM58</accession>
    <name>A0A2X0NM58_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Succinyl-CoA:3-ketoacid-coenzyme A transferase</fullName>
            <ecNumber evidence="3">2.8.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C010g05911</name>
        <name evidence="5" type="ORF">BQ5605_C010G05911</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate</text>
            <dbReference type="Rhea" id="RHEA:24564"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35973"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.8.3.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 3-oxoacid CoA-transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.5" evidence="3"/>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NM58"/>
    <dbReference type="STRING" id="796604.A0A2X0NM58"/>
    <dbReference type="UniPathway" id="UPA00929">
        <property type="reaction ID" value="UER00894"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008260">
        <property type="term" value="F:succinyl-CoA:3-oxo-acid CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046952">
        <property type="term" value="P:ketone body catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.10:FF:000001">
        <property type="entry name" value="Succinyl-coa:3-ketoacid-coenzyme a transferase subunit b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012792">
        <property type="entry name" value="3-oxoacid_CoA-transf_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012791">
        <property type="entry name" value="3-oxoacid_CoA-transf_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014388">
        <property type="entry name" value="3-oxoacid_CoA-transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02429">
        <property type="entry name" value="pcaI_scoA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02428">
        <property type="entry name" value="pcaJ_scoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707:SF60">
        <property type="entry name" value="ACETATE COA-TRANSFERASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000858">
        <property type="entry name" value="SCOT-t"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="5-glutamyl coenzyme A thioester intermediate" evidence="4">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000858-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY13607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="521" mass="55437" checksum="E7726DACFBB59E03" modified="2018-09-12" version="1">MMSLLPCRSSLRASRPLARAFSVSPRVLSVAPTSAKSSVSKIWGSAEEAVADVKGDSILLSGGFGLCGTADTLIGALSKRPEVKNLTCVSNNAGVDKLGLGILLHSGQIDRMISSYLGANKHFEGLYLNGKISLELTPQGSLAERCRAGGAGIPAFYTPAGYGTAVQTGEIPIRYKEGGKQEVDIPGKPREVREFDGKGYIMEEAIKGDYAFIKVWKADEYGNCVFRYAAQNFSGAMARSAKVTIVEAEEIVPIGSLDPNNIHVPGVFVNRVVQSTTPKQVEIEVLRKSDDDANSGKDAGQLRRERIAKRAAKELKEGMYVNLGIGMPTLAPSFLEPGTVIHMQSENGILGMGPYPTKEQVDADIINAGKETVTLLPGASTFDSTESFAMIRGGHVDVSMLGAMQVSASGDLANYMIPGKMVKGPGGAMDLVSNPEKTKVVIVMDHVAKGGKHKILDTCTLPLTGVNCVSQIITDLCVFDIDRANKKMVLSELQPGVTVEDVRKATGAKFDVADNLIELSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NVL6</accession>
    <name>A0A2X0NVL6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BQ5605_C013g07278</name>
        <name evidence="16" type="ORF">BQ5605_C013G07278</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0NVL6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23823">
        <property type="entry name" value="RWD_GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14046">
        <property type="entry name" value="STKc_EIF2AK4_GCN2_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000050">
        <property type="entry name" value="eIF-2-alpha kinase GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016255">
        <property type="entry name" value="Gcn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024435">
        <property type="entry name" value="HisRS-related_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF136">
        <property type="entry name" value="EIF-2-ALPHA KINASE GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12745">
        <property type="entry name" value="HGTP_anticodon2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000660">
        <property type="entry name" value="Ser/Thr_PK_GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RWD" evidence="15">
        <location>
            <begin position="13"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="224"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="607"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="142"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="684"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="767"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="142"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="684"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="716"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="860"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="613"/>
            <end position="621"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="636"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="637"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000660-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000660-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SGY15170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1689" mass="188846" checksum="E0C59BC8F0421932" modified="2018-09-12" version="1">MPVMDEFKELQEGEMEVLRSIYGDDFESVETRTAWKSVNAAHEFRVRVRPVEEPLKEIVNVKIHFKLPLKYPKQAPTFTLDEPVGLETNHLNALNTHRRQRTLLQRESTTTLLGSEMIYELCSIAATFITDRHTDMNKNSLEDQRKLRSQEEEKANREALERAEAQKQREQAAEAARMAQLISGDVKRKEELRAERDRQEKLKEREGIEGESLQVGEGGERKVKMLISTDGHGTKEVVAKLGMPSGTDWIGRMLPVELMMGMEAALSANAYVIDVLGPYYLTPQGKRKLSKVDTDLTRARALRHPNILSLYGSVLARYTPSFFPDNPSAQPLLRTTAGWSLIVLHEQVPTAAQTLEYLLATVGELKLEKAITCLQQLVAAVEYLHLSNVTHRSIRPKAIWVCNERSPVGNSTVSIRLGDVAWFQRIIDLNKAEPWVAAPSQDDLPESWMCPEVVDDPFAYDRSRDMWDVGIVFAQMVFGTDVHRRYASPADLLQSIPRNSSPVLRKVLSDLLLTEAKKRPTAARLSAQLLELSVSGGAHDSGVSLTPMILSTTPTNNVAAWPNKVRGAGTPMFSPGVGSRESQMAESSQVGFFWQPRPTGSRYRSEFEELEFLGRGGGGQVVKARNRLDGHLYAVKKIRLPTDKQAEIKILREVTIWSRMNHPNIVRYHTAWTETEDVSQSSYVIDGEGSTQPTADISAPSTESVSTANEATGDSNSDDDSDPVDFDSDDDDAAATPGHELDIDLGLDDLDDVDFLSAGHSKSVSYPSIHFGNEDNASTDGRISPAVSRHSKHSTRYNSPVILATPKQTRTLYIQMEYVEKLTLREAIEEGLSEIASWRFMNQILSAMLHFTSLNIIHRDLKPSNIFIDGKEDVRIGDFGLAVNQGGVLDPTDGLLSMDSSMDESDFTSGVGTSLYIAPETLSRTRTERSIKYSNKIDSEFREDVRRPVLRDSFTCYREPTVYSLGVVFFEMFHGPFKTGMERIHVLRRLREPEIRFPPSWDMVRLARHTKIVQTCLQHDPEKRASPKDLLASDLLPPRVGDDSIEETIRLLSHSGTTHAQTLITALFNQTVEDRIRKDFSYDFYDGEGAKVDNDPYAELVRDKLSRIFRQKGAVSMDSPLLMPHSNIYGARDPVRLLDSDGTVACLPFHLNIPFCRMVARDTSLTRLKRWTIAPVYRHTKAGGQPRAVLNAAFDIVTDAVTAATEAEILIVVEEILAAFPLTGQKVHVLNHSKLLDAVVDRVPEKQREAVLEVLQQHGRLQRSWVKTSSELLKIPGVTKAMCDEFGLLNTSGTLAEIRSLVVDSPRLKHVVQEGFDELQEILNFSQQLGIKNIKISPLLATNWDFHRDGVLFETHHIRGKMREVVAAGGRFDEVVSRLAAPEVRYSGRVPHVVGVSISVAKLSQAAADANAAASKSLMNRRDESTRSYGPWSVRRCDVYVVSFVANLIEARWDVVKDLWKAGIKADLMYDDNFLSLTPEQLQSACRREGVMWIVIVKPGQAATAHGRHALDDAERTLKVKSVLLPRSELTSFLSKEMREQQIADESSNEAFDAVGSLAEQAKSLQNIYPILADDDVRQKGRAKQKSMIASRAQKSVEQAAQAAAEAPVFAVDVDGQAYRKMCESAAWVDDDEAYRSVIQHAPNTKRDYIASIRQQIRKHKAASSTPLPSFWLFSLREDRSVLLTCDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NXG8</accession>
    <name>A0A2X0NXG8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C003g01896 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C003g01896</name>
        <name evidence="5" type="ORF">BQ5605_C003G01896</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY37829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NXG8"/>
    <dbReference type="STRING" id="796604.A0A2X0NXG8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035025">
        <property type="term" value="P:positive regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051480">
        <property type="entry name" value="Endocytic_GEF_Adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46006:SF7">
        <property type="entry name" value="DH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46006">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="338"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="64"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="149"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="385"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="444"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="515"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="928"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="176"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="232"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="385"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="444"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="940"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="950"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="972"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="994"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1039"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1077"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1101"/>
            <end position="1118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY37829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1156" mass="123182" checksum="7EE973F7E476AA88" modified="2018-09-12" version="1">MRRFLGIKAKASKQPLATHDSSEPTPELWQHPSAATVDAVARSDASTSTSGAVYAADTLRATQTYDRAETSHPPWSTIARAPQHHQHHDPSLNAAPNSGRPLAPASSSPRDPSTGLFRRSSLASLQSNPSPSVHPKDRRTVRVSLGSAVAPAASMDKAQHQDQGPSRRGHPHSVIPGGPSADSGSGATANHAAPTSTSTSTSALASTSTIIPTTTNNGRVSIANTLPVRSNSVASTNAPTTTLGQERTTSPLSISPSSITAHSHLSFASYNTRLGGASWGVGSGGRWNDEERDPTAIYGEKSRADSVNPWTPACTAPATWSELANPDLVDNVSARERTRQEILWEVVASEQRYVLELRSLVNLYVAPLLHPLLTTTTVPAATTATPSLSFPSSPSPIPTVVSPRPSSSSSTPYRHSASIHAESSSDLPIAARFSRSLHTVSRDHLPELGTHDTDDVSSSLSTPRAGSRATQNSVNASSPEEKVMNARLSLPNPAASYRGPSSQGMRGRVYSSFGAQSTSSLTGPDAGSSHKPRAMSTTNRNRFSTMSFKNAMASMRSLATPNHEMADEAEEAGPAPILPDALRNVLESVLEMLKGHEVLASSLKEQWAKAFPLVRGLAAIWSDQPWFLETYANYVLSLEEALALIDACIPSVHSINKDGPANSSNLVTLTAKFLKRTSSMPSPSTSATVPASASDPANLQRLKRTLMQLEEKATEAGESGLGLCLSKPLMRLGKLPLLMQALLFHTDPTTHEWEKTRAMAIEVDELVRSIEDEKIEEEERSRARDGIARIDGIQDKALMAPRRSRVLIEETIAPVDVEGGPSSGAVMKEKSLMISLGTKGTLGRRKGTNLAKGGEEWLVHFSDVTVRCAKVRETDLPFGCGFSKKTEGAKREKKLKKGKVRNLYRFVKVEKWETPEDAEKNLAAWLGRPSQTESATAAVEEAEDADDDAESRMSFRYDADDPRPVSPRVFRASSLPAAGATTSGTGGARKVPRQSVTTQSVVAKQSPAIQKHGQRLRVASETLPRLTSPVSRQRWETPTAASQARATPVGSGSTRASSRSPNSTPASGNTRSGRGLTPSATSTKRASSAFATTSSRAGQAATATNKKQSSNSTTNKVVPLSVSTTSINGLGARDQSTMALYGKYWEATDGEKHVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NXN2</accession>
    <name>A0A2X0NXN2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C015g07956 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C015g07956</name>
        <name evidence="8" type="ORF">BQ5605_C015G07956</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY18027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NXN2"/>
    <dbReference type="STRING" id="796604.A0A2X0NXN2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF64">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="479"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="84"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
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        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY18027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="580" mass="62281" checksum="B2CC1EE05784B7E0" modified="2018-09-12" version="1">MADLTLVRSSSRNSAGGGGGSGRRERSSTLGGRKTMDNEERKEGIIDEEDEDPDNGIVPEWMNAGDVQRSKLYNRFSDRKKKLIVALVAVSAFMAPFSSSAFLPAIPAISEDLNTTPTIIDITVAVYIFTIGAMPLAWAPYSGLYGRRPIYLCSLPIFALGSMGVALSHNLATLIVTRTIQGVGSSAVLSVGAGSIGDIYQRQERGTAMGYFYSGILIGPAIAPAIAGLLSEYVRGNYGWRVMQWILCGLGVIASVLCFLYFPETAHEIPIEGIIRARRQKRANEGLPIEPRWKSSLCSFLWLNPLAPLRLLLLPHILAIVSCFFGIDVSEVSFVLLTTYAVLVPLTDTIHSNYGISNAAILGTFYLAQGVGNAFASFCFTGRMADHTLKKWLKKRKGVYVPEDRLRATLLGGGLVLPCAVLALGWVIDLGSGKVGLAFTVILLFLNGVGLMMILTAANTYCVDVLQHRSSEVIAVNNFARYTLSAAASAFILPLIQAIGLGGANSFAAGLAWIGFGLVCATIRWGEKMRRLGEKWEGTASAGTNAALITKAEEEGERGLEEALVAPKVEAMAEVNNADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NXZ0</accession>
    <name>A0A2X0NXZ0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C014g07451 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C014g07451</name>
        <name evidence="2" type="ORF">BQ5605_C014G07451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY18727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NXZ0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY18727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="164" mass="18181" checksum="C5F2ADC66F300463" modified="2018-09-12" version="1">MARGRRKKWTPKAHAPPPISEREVRLQSRRTRLQVLDLPGAAASPSAFSAPFPQHTYMNRARNLIGNRASKTGLRMLSPPGPPSEASPTTLTRPIHIPRSDCEGCVLLDLSPGSEKKLYEPQIRQRVDYSSLQSRRSMTSLQGDNPKSLEPPVPESRPHGETSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NY09</accession>
    <name>A0A2X0NY09_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BQ5605_C014g07471</name>
        <name evidence="16" type="ORF">BQ5605_C014G07471</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activation signal is received. Near telomeres, it may counteract gene silencing caused by the spread of heterochromatin proteins. Required for the RNA polymerase II and SPT15/TBP recruitment to the target genes. Involved in chromosome stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2A.Z forms a heterodimer with H2B. H2A.Z associates with the VPS72/SWC2 subunit of the SWR1 chromatin remodeling complex. Also interacts with RBP1/DNA-directed RNA polymerase II largest subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY18776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NY09"/>
    <dbReference type="STRING" id="796604.A0A2X0NY09"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000005">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="14">
        <location>
            <begin position="26"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="15">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SGY18776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="232" mass="24632" checksum="43B56377AA2A0AE2" modified="2018-09-12" version="1">MSSGGAGGKTGGKGGKGGKGGKAGGDPKAQSTRSQKAGLQFPVGRIHRYLKARTQNNMRVGAKAAVYASAILEYLTAEVLELAGNASKDLRVKRITPRHLQLAIRGDEELDSLIRATIAGGGVLPHIHKVRFVLPYCCEPTTTDLDARGRPTQNLIKVPGQLPPQGMQMSQMKMGKKGIIKCVTTRGVWDNAFGIDLVCDLFPFVHHDGATYKIPAQQAAMARVGAIHGPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NY36</accession>
    <name>A0A2X0NY36_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C017g08372 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C017g08372</name>
        <name evidence="25" type="ORF">BQ5605_C017G08372</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY19898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="528"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="767"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="869"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="776"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGY19898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1413" mass="154679" checksum="247A3BB20F189FA3" modified="2018-09-12" version="1">MVGRRLTVPLLKRLYLMADSVTMDVSLATDITETILSIRAVTIDLHSLRSPMIVVDQRWLRPDPYRRLLNLACLKVLLSYEPNVAAQPTRVIKSSCPVIRTLWYQGEQPLSSMSNPAISTRHATCATREAGRNGSTTSKPNARTDLEHANFQAIALLRRSVSLNIKKQIKDGFDHTPTDVLKMIKKAVAAGTVTDIFIKLQALLDAGPPPSGVDAFEKYQANTIELFNTLSGYNLTFDQVISIRLIHFGKDLYKEYYTQALRQDLDKLPDPIEALQTLQTQAESTPAHKPVAMVASLTATDRSSSTPSAPCRHCGGPHWNRKCPVKDKKSKASSAPSASLAAAPDISTLVNGPVRGYLTAAMSTLAKPSLILDSGATHHIVNDRACFTNFRKCKPAPLEGITGEAVNSIEGVGSAVVRSFDGSIGQLHHALFVPSAPVSLFSASRANAAGYDINLSRGKATVSVDGSICHTGEITNGLYHMHASLVDVTTLIEQPVNMEVALNADLKCDTCQAGKITHHPFPTVASNRSAQPLDRVHMDLLAFDGAVSLGGAKYALVIVDDYTRYLWAIPMSHKSDTFAAFKSWLAKVERSSSRKLLAVRSDNGGEFLSNEFSSFLEEQGITRQLSIPDTPQQNGVAERANRSITEGVRSMLHQSGLSHALWAEALATYVYVKNRSPHSANSGVTPHTRWHGSKPSAGHLRVFGCRAWKAATTEARSKLDPRGIPLVFVGYDLESKGYRLFDPATRQVFKSRSVTFFEDEFPARREGITAAHAPVDDDDDDDDDDEVVVLPDQHANQAPPDQAELPAALRFDAPGPAWQPPVGSRPRNPPARYGALASLRSTPSAFAFSLGKEVTELVADLEAAGIDTSTANRPLSEPEDPFSLPSSDPTTWNEAMRHPHAAAWKAGAIEEFRSMKDDLKVFSVVGLSSVPKGATILPSRHVFRTKRDKAGKMVSLKNRIVAQGCAQGPNSFNNTFSPTAKYISIRTLIAHSASKGHHIIQADVDKAYLHGVLEEEIYMRVPTGIEGYEGKCLRLHRSIYGLKQAGRVWNDTINATLASLGYRRLACDECIYRHEDAGGDHYIALYVDDLLFFGPDLGEIDRVLDQLDTLYGVKRLGPAEWVLGVQVVRHDDGGISLLQRQYLLDVLARFNMSDCNPCKSPMEANLQLSPEPDTDSADNAIYRSMIGSLMYAVVATRPDLAHSVGYLSRFVGKAGDTHLEAAKRVLRYIKGSLDLGIHYTRTSAPLLGYEGYSDSDWGSDIQTSRSTMGYLFKLAGGAISWSSRLQPRVACSSTEAEYLGLSHAAKEAVFLRSLLTELGLDTSSPLRLLGDNQGAIALTQNPVFHARTKHLRMLEHFVREHVRNGEISVTYIPTHDMVADIFTKPLPRVVFQRHCDAIGLRRISGQEQGGVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P0G6</accession>
    <name>A0A2X0P0G6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">BQ5605_C018g08785 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BQ5605_C018g08785</name>
        <name evidence="16" type="ORF">BQ5605_C018G08785</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY26778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P0G6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="8" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="15">
        <location>
            <begin position="125"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="14">
        <location>
            <begin position="390"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SGY26778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="478" mass="54596" checksum="82186E3F5189E2AB" modified="2018-09-12" version="1">MLAEATLDPAFLKALKDGYLNNTHCQQAIKNIDSTLDYSYKDGIARFEGRIFLPKTGDFRKNAIHDAHNATGHFGLHKTYERLRRDFIWLGMKESCKEYVESCSVCQTMKMHGTGFAGRIHNLNVPDRPMREVGLDFVGPLIPSNGNDALLTVTDHLSGYVRIIPCRTTDDATTTADRFFDGWHRYFGMPRVLVSDRDKLFTSEFWRAYTGRMGTKLAMSTAFHPQTDGQSKQTNQTVIQVLRTMVNRRQNDWSKHLATVEFVINSSVNRSTGKTPFEVADQSNKVRKLEPEFAVGDRVLVDSRDRRLRYKADGEARSAKFFPRFDGPYEVLAARPETSNYKLKLNAGDKSHNVFHTSKLRHWTDNDGVAFPGREATEPASVVVQGNEEWEVDRIVDEKGKGKRKRYLVKWKGWADSDNTWEPRAHLEETIVLEEWERERAEGERGKEGRGGSLVQVVESVRPVRLGLMRRERAPGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P1J7</accession>
    <name>A0A2X0P1J7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C002g01398 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C002g01398</name>
        <name evidence="1" type="ORF">BQ5605_C002G01398</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY32675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P1J7"/>
    <dbReference type="STRING" id="796604.A0A2X0P1J7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY32675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="202" mass="22879" checksum="FD113EBDDE345EDA" modified="2018-09-12" version="1">MSATGIRVVERALNGTRQQQALDSLRSPELALRDDILSSEPRLFIFFIGAGGSSRGTVHATYRTNVFLRALVAEIERLKRVGLDILVYYVDEDLTSSLCSNQDCRNEHGHRSRSVSEIEQVRVEVMFAGLITNVVLLRRPTLYRLNDKGTVEGSAKPLFRVYQCERGCQPPVHRDLVAGKNIRFAGLHCLFSDHHPFKQYHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P260</accession>
    <name>A0A2X0P260_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C002g01589 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C002g01589</name>
        <name evidence="3" type="ORF">BQ5605_C002G01589</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY34101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P260"/>
    <dbReference type="STRING" id="796604.A0A2X0P260"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070692">
        <property type="term" value="C:CTDK-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032786">
        <property type="term" value="P:positive regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042326">
        <property type="entry name" value="Ctk3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024637">
        <property type="entry name" value="Ctk3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28291">
        <property type="entry name" value="CTD KINASE SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28291:SF1">
        <property type="entry name" value="CTD KINASE SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12350">
        <property type="entry name" value="CTK3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTD kinase subunit gamma Ctk3 C-terminal" evidence="2">
        <location>
            <begin position="22"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY34101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="198" mass="22389" checksum="9F4C2E999052DFD6" modified="2018-09-12" version="1">MKNKSLTINDTASCEPISLSLSRNDILRRIEDDRERHKRLRERIWVLPIPTSLFIIPTANSNPTWSNLSSIKPSPISPASPSEPPSSRIHKTNTSSSTLAPSTSGAAVQRGPEVPIDLEFEQTWARLNEEREFAELERNDVEGEGSSGHGEGKAEGRVRKKRKAEVDQVMEEENGTSRWLFDESELRAMRIEYERCFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P285</accession>
    <name>A0A2X0P285_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C002g01619 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C002g01619</name>
        <name evidence="7" type="ORF">BQ5605_C002G01619</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY34354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P285"/>
    <dbReference type="STRING" id="796604.A0A2X0P285"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF5">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="6">
        <location>
            <begin position="213"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="418"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="816"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="787"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="418"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="856"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY34354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="943" mass="106136" checksum="9745C1C90C2FCC00" modified="2018-09-12" version="1">MDFLPLNPLTMSVSGLGMIIWAGCRHFALHKKITSKQSARGSFLFDEAFSVMKYFFVKATEHTVEEAQAFGNNFIPAPWWVRVVRVLIPLDTRLEANRILIDTLGEDDIQNVAGGKEWWQRCPNPDGALNGEWISMKKDWHGLGANEVDDDDLEKIKCEKVEAMKRKSQDDHKRRYKLGRQREERRAKGEDVAYEGDEEGSAYEHDLDEMRCILYIHGGAYFFGSPNTHRFSIWRYARKIGGRAFALQYRLSPQFPFPCALADALASYIYLIRPPIGAKHKPVDPKKLVIAGDSAGGGLTLALSCLIRDAGLPAPAGIVLISPWCDLTHSFPSILQNTETDVIPAFGLGLFKPSMLWPPPPAEWQERADRSTSIKGLKHAAETFEQERRATKKTSMFFNGSSRADRKGEQLLEEVEKFPEDYQRAEHTETGKDGAPDGSGGSAQANGESKAEVGKVLKLKIDGEEVEVRDQIQLYATNDQLVYPFVSPIWQPSLGGLPSMYVMCGDREVLRDEIVYMAHRAAHPDRYPVRQALLDANPERTKRHAEYPPTKVHLQIYDGMCHDLPLFAFTTPAKYCYRAISSFVKFVTADENESDVDGEVLASPVSNTGMQLPLEISTAHEDAQLHHERAAEMAPPTPISSEPQDINNLTQPRSQIHIDTSVPTEKTAHNGEVKRKRSAFSIAMKSHTNLVERANGDSPTGQSDLSLSRHYTDLEKTIYASTQPFHRPDYVDNMVRERVSLTGVVRPMEPEEEVEVLKIPKDDLGLVKEGPVKRYLAGKAKWDKKFKRNYEHVMRKREEQLKKSMREEAERISAQLKQRTLNKKNSSKTSSHQGSPSVPPSLDDADFPLRRMDSPEPIEDAEEGERDEHIHLGIWALPGERPPPSSIAARKDTKEARRLARVLDERYLKLSALSVWNEVHRMANKAAEPPGEDLGAHHPRATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P3A0</accession>
    <name>A0A2X0P3A0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C003g02090 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C003g02090</name>
        <name evidence="3" type="ORF">BQ5605_C003G02090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY38858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P3A0"/>
    <dbReference type="STRING" id="796604.A0A2X0P3A0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="73"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY38858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="157" mass="17419" checksum="1BC75CFE10BEAE9B" modified="2018-09-12" version="1">MDEYRPYRVGRTPGLLENMNEGNTLPLIALVSTRHPPLPKTFKDAMASPEAESWYAASVKELDSMGLHKAFKQVSSSPTGARALGCRWVFTRKEDVEGNIISYKTQLVVQGFAPRLGIDYNKTLALVSSITTILFVVRLCAAQVYLPRSHVICDSCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P3Q9</accession>
    <name>A0A2X0P3Q9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C007g04858 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C007g04858</name>
        <name evidence="2" type="ORF">BQ5605_C007G04858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY64003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P3Q9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY64003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="56" mass="5608" checksum="89CBA0E2AB685305" modified="2018-09-12" version="1">MSSASEPDSHNVEEVVAEADAGAAATAATGVDDSASELSRSSGRQQTPEEQDGGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P7B0</accession>
    <name>A0A2X0P7B0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C001g00886 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C001g00886</name>
        <name evidence="6" type="ORF">BQ5605_C001G00886</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY50456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P7B0"/>
    <dbReference type="STRING" id="796604.A0A2X0P7B0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY50456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="454" mass="50592" checksum="7983B48577F922C6" modified="2018-09-12" version="1">MDIATKSEFPNWFKANTGRLHDEATHQLGPDATRTEIIDTEVARRTLWIIQSHAYFYPMMDRSSSGFNLLDVTAFLPCDDEAYLQGRSPRTCSSLMGTAAALLSPESVSQPDQSLLISIVQVTELWAKVSRKASSIDPALHGSWSEAELLELRSELAHWEADLSPSHRWSPVNLKHWREQKQDVAFYATNSTLKLAYMSLHRLEVSLLASTAGVYDPQYQTSLVDRELHTALSWERTTKMMTNEAFEAVAYAELFFSTRGPRSGCPPFLFYNVFVAAEIALYVLKCQCFDEFYAARAETTFMTGLNILLEAATTWAVAARWHAHLVEGYGNGGYPNPFESSSTLGAALLPSLKPALSGLSMPPPSYPSTEFETYDWDLTQQYTNLFQEETVSPLSSFGGFDPHSLTALESSSSTPLDLPPLANAASPNAVRPEFAFTSPDDLTNFSFPYWFEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P8A1</accession>
    <name>A0A2X0P8A1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C008g05344 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C008g05344</name>
        <name evidence="3" type="ORF">BQ5605_C008G05344</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY80271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P8A1"/>
    <dbReference type="STRING" id="796604.A0A2X0P8A1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="333"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="420"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="495"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="570"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="671"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="719"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="811"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="454"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="581"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="671"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="681"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="719"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="751"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="811"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="875"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY80271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="943" mass="105815" checksum="BC3C59C4D2883B8A" modified="2018-09-12" version="1">MDPIAAPNELELDASNKPKPIDRNRPGCESCTSTSTSERALSTKPMRNDQAAPDPEDQDDEQEQERDGEDEDAVMPPPPAQVVEQNLGQVVAPSTPADSWRVAYIYAYLVKFTDLYPSSTPNKKSLLLDIKSFEDALLASSPPSTSSLRRHPQTGLLQSDYRPASTIHRATWLPSEITQAEYEYDQLVAQAQLDHLPPPPYPTTGPLSTESYEIASPPKSALLIEIMQSFYDIMGYFPEFYNPKDRKGWFAWSVRFVNTRLGSGPLKGGIGWEVNLMRRVGVKIGREDEGNFWRLKWEEKVHVIQHIIDYLLTYGKAVRREIKVAYDNERDPKDVHYESSSSSEDEIDDASTTTDIADDAPTQEEPEALNPLAFEPLGTTSTRTIASFEEGGDGVEVKEESLMMIYALDTSARLFGLAFPSTRGSGRSDDEEEEEEKLSSRPSSANPVFEWRTLTRSIEEYNEFIRRVEEVEAKDAQSEEEGKVKSWLVDAPVQPSVKMRIPPKTRTGAALGTNKKRKRRTTTSGMANTPNKRPMRSSVLGRKTSSYFEVEEIEDDEVLVEGGRRSLRTRARRMVQQQQEQLEEDESTDEEDEDDDEFEPEPVPIPTKSLSQVLKDRLPSVQELQTVLDGLHAQREEEEKFIQERLGGGGNNGSGVASSSKITLDTIHGRSAASSTTTLPLLPPRLPTPPPPPVVSARSARLRVQEEKAHHDYYTHVNEEKERQKIQHELAQREHKKRQEAKIKAQTLKIARAEEKKMEDEERERSKRERERKELEKRIKERRAEGEGGRRVSKRLSLMLEVDEERLRVLVEEETKREEERRRRKEETMEKEGRQGLKEAGEVKRGTKVSKVEEGGEVVGPPGVEVAMGDGTVPANGSTSPSPTEAVQPPTTNGVEAGPVDVSVPANEESTPIVEAAPSPFLDTPVAPPIEASAPLTTRDEWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P8H5</accession>
    <name>A0A2X0P8H5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g04152 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g04152</name>
        <name evidence="1" type="ORF">BQ5605_C006G04152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY56621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P8H5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY56621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="95" mass="10679" checksum="119D4F87DFE5852F" modified="2018-09-12" version="1">MHHLDLARRFRLARTDPLSPVDAIAVLPTHAGSRAVLATHVRFWAFTALSTDRCVPHSQDYLPADEVAADREFHLAGRSQLLAARYETFDVARLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P996</accession>
    <name>A0A2X0P996_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C007g04463 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C007g04463</name>
        <name evidence="2" type="ORF">BQ5605_C007G04463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY60657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P996"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY60657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="148" mass="16461" checksum="EAE60D98A612BA50" modified="2018-09-12" version="1">MTSPPTPDIEDLPMGTGPSSFDLDEHRIYVASLDSPPPSPNLSPHTQEIETEAHTNLTNLMIPTTMLKHLPPPLPLDVIKSLEAADKGAERGAAQALVLYQPLKWTPQEREQQFEEFRREQARQESFDDDEVDLDSVEGAEGNGMEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PA94</accession>
    <name>A0A2X0PA94_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C007g04762 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C007g04762</name>
        <name evidence="8" type="ORF">BQ5605_C007G04762</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY62982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PA94"/>
    <dbReference type="STRING" id="796604.A0A2X0PA94"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096:SF0">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53213">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Extradiol ring-cleavage dioxygenase class III enzyme subunit B" evidence="7">
        <location>
            <begin position="97"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY62982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="354" mass="38842" checksum="B5CCF67302211DF6" modified="2018-09-12" version="1">MLRRLGRVFSTTPSSNASHLSTQASTMSTATTTNQHLVNTTPEEWRKAIAALPALTETEQRIPAIFLAHGQPMLITPPELISDERKAGLGEVQGPNSALVQFLKDLGPALIEKYNPKAIVVLSAHWESRGGALVSDWQDENPLLFDYFGFHPALYKVEFHSSPDHALSERVVHLLNSSNISARLLGPTEKRGDDGRGFRGTGLDHGVFVPFKHMFTDNCPIPIVQVSIDQSLLPQDEYNLGAALEPLRSEGVLIISGGLTIHTFQDFNAFSLSKSPEIYKEFEKSIIDAAAIDDPEKRKKALFDTAQHPGFRRAHPREEHYAPIWIAAGAAERQGGKASTLMGHHGCKTIAFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PC04</accession>
    <name>A0A2X0PC04_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C004g03095 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C004g03095</name>
        <name evidence="3" type="ORF">BQ5605_C004G03095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY70041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PC04"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="178"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY70041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="521" mass="56566" checksum="5E1C52147C19707F" modified="2018-09-12" version="1">MLQDVVNHLRPTVRLRLTPVPFAGGRVVEADGVDDDLNHKPRWSDDEPDQPHINIKQSLLTSSPGGRTTSSAFSSSPAAHSRFAAYDAPTSPDAGSNKFASSAPSSSPRHEHADRVDSHVTSALLSVAVGAIARAASAASANSETRSMLQSTAPAIARPIQLTDNDDIYLILERGVVMQLGRKAKRPTQPRPETTLPVQLAKSAKHASRMHCTLRILPKTPQTPPHKVVVQVHVLGMNGMKIDGRLYRKSAVAVLTVPIGHKLKLCLWSWQGVVHIADSKLPKQRKATDIPYTAPLSPVALSVYDSLTDGDSSNLGHRDGSFELATPNEKSHGPASPAHSDHSLLSALPSSPSAQEDDEVEMDDVDQVSAESTRAAALVESLGLDLPGLIASAIVFSPRSTVDIETVVQSLLREVGGMWDVLEDGEGSEDSSQNREDRAVEAWWEVVERVLCQEPFFGCIDNAGLKDASGHPLQPLFFYMPDSDPSRSRVAALEPFVKRVRGARQRPAQYFWRKPSLRKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PCC7</accession>
    <name>A0A2X0PCC7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C005g03368 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C005g03368</name>
        <name evidence="5" type="ORF">BQ5605_C005G03368</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY74530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PCC7"/>
    <dbReference type="STRING" id="796604.A0A2X0PCC7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052743">
        <property type="entry name" value="Glutaminase_GtaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032514">
        <property type="entry name" value="GtaA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033433">
        <property type="entry name" value="GtaA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF1">
        <property type="entry name" value="GLUTAMINASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987">
        <property type="entry name" value="GLUTAMINASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17168">
        <property type="entry name" value="DUF5127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16335">
        <property type="entry name" value="GtaA_6_Hairpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016095300" evidence="2">
        <location>
            <begin position="20"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A N-terminal" evidence="4">
        <location>
            <begin position="171"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="3">
        <location>
            <begin position="404"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY74530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="782" mass="86796" checksum="49092371E2D9232D" modified="2018-09-12" version="1">MHAIPGILVPLLLCECALALSLRSSPQAELNRPSDSELIGRQSMPSSGRAGEAQDRFRLPDVPEQDGPKMTSTEFYPLLPPAIPLAVKSPYLNAWLPTGNDRQDAGHLAGHWPRFWPISYPHTERGYRLGWSGMIRIDSNQTYVFLGDPGSTPGLKRSKMAAQTRFEYTASRSIFSFKAGGVHFNVTFVSPITPEDLISTSLPLSDLVVEIDSKSLKHHHVEVYTDITGEWATADSNAPITWDFVHHSAAGIHLVRRRDELLFEEINEQAEWGSAVYATEMSHSTRAGSGPARKLRKEFAEQGRLSGALDAQYRAVNDDQPVFGFSAMMSPQKPSVTFTIGHMRTPYVNYVTSGGQVNLDGYWMTQFPTFTDAVAGWIKNGSAIHAAATSFDRKLRRDAIRVSGKNYAAVVELSARQAFATFEITSGGKGEGDTVAFLKEISSNGDMSAAYHHYMFLQTVDVIFPLYPILAYAQPKLIKLLLEPLLRYATSGLYPNQWPCHDLGTYPNARGYNDGNDEAMPVEEAGNLLWMVLAYVQLSHDVEFVEEYYHILTQWTAFLIQDGLIPAEQLSTDDFAGTLSNQTNLAVKAIVGIGAMGGLAAKTGRWVESIHYGATAKAYAAEWYDLALTPKPIDLPHAKLAYQDENSHGLLYNLFGDRALNLGIFDRQLYEWQSKFYTTLLQPFGVPLDSRHLWTKSDWEMFASASSTSRDSRDMFVDSIVKYLKAGKVDAAFPDLYETTDGNFPGRGLDWPIEGHFSLLALDVANKANGVKRDPFRGNDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-10-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PEC6</accession>
    <name>A0A2X0PEC6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C008g05309 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C008g05309</name>
        <name evidence="1" type="ORF">BQ5605_C008G05309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY80136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PEC6"/>
    <dbReference type="STRING" id="796604.A0A2X0PEC6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050240">
        <property type="entry name" value="DNA_pol_type-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322">
        <property type="entry name" value="DNA POLYMERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322:SF23">
        <property type="entry name" value="DNA POLYMERASE DELTA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY80136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="247" mass="27240" checksum="80D1D947708E50E0" modified="2018-09-12" version="1">MAQIFKQIELEEHVVPGTVPQIRAFGVTQAGHFVLLHITGFMPYFWIAAPKGFVNDLCAPLMGHLNAMIPGDLNPVHSIKVAHKRSLWGYKGDGTVPFIKITISDLRAYPKVRGAFERGEVNFQELFTAEAVMTYESNIAYTLRFMIDHGVLRLPRPLRFCRIGSEGDSSGDEDHALHDGAHGTCTVTDLNSPSTAPTSFDSFDKEKESVLATLAERTFRDEYSPVGIGAPAYAIVFEGVRARESSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PEL0</accession>
    <name>A0A2X0PEL0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytoplasmic tRNA 2-thiolation protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C009g05410</name>
        <name evidence="3" type="synonym">CTU2</name>
        <name evidence="3" type="synonym">NCS2</name>
        <name evidence="5" type="ORF">BQ5605_C009G05410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTU2/NCS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY80937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PEL0"/>
    <dbReference type="STRING" id="796604.A0A2X0PEL0"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03054">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019407">
        <property type="entry name" value="CTU2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882:SF14">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10288">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY80937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="487" mass="54014" checksum="F044378A1C120D8A" modified="2018-09-12" version="1">MSCSQPDPLDVDETEPERAFIAAGSYCSTCFEAYLYSKFKRSAEGVRYFSRTGTSMDHSPLSGRQLQPRREVGGGGGDRHIHVRSRVLLGMSGGLGSRVLLELLKVWFPIRETSSKAPPAFAGLVVVHVEMDTEHGQPDQEQNAFTEHLKTLVESMGIKDVEFISIPLSDIFKDSSTPDSTSETALERHQKLVQLLHPTPSQTPSKTKIDHTSLASLQRSLLFTLLRRKARKEKCEVLVTGEGSDRVAELTIEGMALGRGYSIGEEVGVEWEVLDRQQEQKQEQAKGNGLLVARPVSGILRAEMEEFVRVKRLVVPRPGVDRGEVANGRSTIQAVVTKFVTDLQKEFPSTVQTVLATVHKLGMRSTDARMRIEEGETGSESWEGCAICGGPVQEGAHRWRKAITMSDLVETDHASATRSIEDVEPQTVIGISESKYEESANSLDTSLCYGCLLIPKAIAKTEDLPSYVERQRRSRRRMDDVVKEFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PFS8</accession>
    <name>A0A2X0PFS8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C025g09987 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C025g09987</name>
        <name evidence="4" type="ORF">BQ5605_C025G09987</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000087">
        <property type="protein sequence ID" value="SGZ26888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PFS8"/>
    <dbReference type="STRING" id="796604.A0A2X0PFS8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033934">
        <property type="term" value="F:glucan 1,4-alpha-maltotriohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004574">
        <property type="term" value="F:oligo-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000025">
        <property type="term" value="P:maltose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11333">
        <property type="entry name" value="AmyAc_SI_OligoGlu_DGase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000004">
        <property type="entry name" value="Oligo-1,6-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000087">
        <property type="entry name" value="Oligo-1,6-glucosidase IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF179">
        <property type="entry name" value="NEUTRAL AND BASIC AMINO ACID TRANSPORT PROTEIN RBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="3">
        <location>
            <begin position="15"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ26888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="591" mass="68332" checksum="B8A1322F4ECDBD9B" modified="2018-09-12" version="1">MSHVQKWWKEGVVYQIYPRSFASARGQAEGDIKGIIAKLDYLKGLGVDIIWVSPFYKSYVALSGYARWAIPQYDNGYDIQDYQDVHEPYGKVSDIEDLIAGCHKRGMKVLFDLVINHTSHLHEWFQESRSSKDNPKRDWYIWRPAKYDADGVRQPPCNWRGLFGGSAWDWDVKTEEYYLHYFVPEQPDVNWENPTLRKALYENAIKFWLDKGCDGFRIDTANMYSKFIEFPDAPVVDPTTPWQPAPLYFSNGPRLHEFLKEMYEETFSKYDCTSIGELPSTPLIPDILKFVAADAKEFNMVIQFDLADLDHGKGRFNLMYHDWPLTKFKEITANYQQLTDAKYDAWAVTYLENHDQARSIPRYASDAPEHRENSAKLLATFLLTVSGTPIIYQGEEIGMINCPKSWDIDAEYKDIGTINQWTEMKQAAEEQKDPKLVEEGKRSIQLTSRDHARTPMHWNAEKQAGFTTADETWMRVMDSYKEINVAAQEGVASSPLEYYRKLIAYRKQHKDLFVYGHFELLDKANEKTMLYTKRSASGQVAFVALNFTAEEQSFELPSDVKGEFELVESLKFGASKRGSLGAYEAQIYVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PG52</accession>
    <name>A0A2X0PG52_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C009g05799 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C009g05799</name>
        <name evidence="2" type="ORF">BQ5605_C009G05799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY86094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PG52"/>
    <dbReference type="STRING" id="796604.A0A2X0PG52"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY86094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="509" mass="55690" checksum="4FB90A007247B375" modified="2018-09-12" version="1">MEQPLLPKEEKRASQSSRKTGRLRFEDESPPPTIEFLMRDPNVTGQTPRAIPPPLLAPNRASLSSIISKTVRSAPSSPTDQSKASIFRDSFIAKLIRPIKIKTSADKPVFSCNVVDTSETSSITSDRSATVTPRTPVTPRTPVTPRTPVTPRTPVTPRTPVTSRNPATPRTPVTPRRPVASTSTATVRPPNLRKQASSDSATSWISTSKRLTWPVPPSSDADIAESFSSSNHYPTAHFPWQPDPTTPVPSGSSELELGSEYGDKEQAWTRSLRTRMRTPVSNMMKASLKRRESTTSFISRDARPKTMAVEFSKDLGLLSFPCTLDELDSSQREIASGGIPELLCSLLLLTRSTSAIDVSSPTPSSEYLGTRPSIEQLQFVHLVLSTYALSNRAEPLAPRKTAVALHAFPAPTLAEGAAKLCNEVRRLRLTASTRVQKTLSATPGETTDDADVKFVLTVTGIAMIEGSPERDESWLVILTSRRERDAWGRVLKGAVADVRKMEKSRSLHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PHU0</accession>
    <name>A0A2X0PHU0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C031g10911 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C031g10911</name>
        <name evidence="3" type="ORF">BQ5605_C031G10911</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000068">
        <property type="protein sequence ID" value="SGZ06034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0PHU0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF294">
        <property type="entry name" value="RETICULON-4-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="1020"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="663"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="726"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="795"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="450"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="568"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="743"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="811"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="842"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="863"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ06034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1356" mass="144860" checksum="B850CE7149C871A8" modified="2018-09-12" version="1">MPSFFQTLLRKPSQSYQAAGPSAYDQAPPLPTARGGAGSSSRAPSLRQGAAGSIRSSYSHASSVNGDDAHYGAQGQQWSWDMYGSRKGSAGVGSSLHPSDVGSQLDVKRSVSRAVARRVGATASDADSIRADSVYSNYEDDGRSLRSAKSHSSLRSAASVSSAWTRDQLNGSLTLKVPGVTKRTSRRYTDVANTPSLKRHEASDTASIASSTASDYYRNGSAPSRSRSMSGPDPSTLKTSRKYSSASGTTTVTTSGYQVVTTTEYTSKKPSSQRNKKSTPTLSSSYAPSLTGTDRTPSLYSTTSSTGSSRGSLTPAYPTSSPMLGSPDLLLPPPSLSKDALKKEKRKKHTQRNTLIEEAVKRAGLPLDSVVELEEEPTTAEAVKQKATAAAKKEATAPMKVLEEEQIEHGRKVENEAKPSKEGTSLAAFDGNASDLTTRLRVLHRQDSRTPSLSTTTTAASSEPLTPENEPVSTYTDDIPLAAEKKKAGPGDIPRIVTKFSLAKDADAHEIALNEATPTTPITPVEVPRIQLTRTASDQLADKVQGSIELSGCDSQSPRKTEGEVSRRSSTASRKSSPESVSRPVMSGPSLGSDSPRSKRSSRTASVGPIEDLKASTTTTTTAAQDQPQWMKRIKALGEPIAPLVEPPKLKVKTLEPHWTVKHHVEQQQQSRASTSQDMRRPASAGNLRRPKSIMAPMPEEREDEDHTPALSAGALALAALPMPASRNARSLSSPSRRVPTWAKERSTGKPRNPEPRPAAVAPTPPPPAILPHHVLAPRPDSLFLPNPIYYDGSARQAPRPTCKQEDAASTAPTLGSSAPSSPSTPLRGAESAPRAKRTTLDRSVSLSQSAPAGASDVARSETAPQRTMSLTRRNSDNSAQIQFTPLPFPFLLESSSESPRDVLQAVSSYSDAGSDDESDARSISGFSAMSMPVAGAHSRPPKNPRHDIIAARNRESLVADPIDFTATQQTTSLMTAVSVSAIAALGAQPKTFASSGSGWSLFKKAAPPLASTASPKKFDPLRDLTVSSMQPLPKKVKSDEVLVEVFAVPIERVDVDRAKKAASQQEGFGWIPGRGFYGKVVDTGLEVNKVKQGELVWGVQPLKKSGALADLITIHKSLVTPAPSCDLTVEQIATLPIAGAASLQVMEVLCSTVPAGAKILVLGAHIGVGNLCLQLARHLRPARDLYLVAQCPPERREDQVFCRESGASDVLLDDPLAAINRLHENEFDVVIDTIGGSKIYEAARRVLLNSGSFVTTVGESSAVAPTSSTQFKESVRSFRRNIFKKNKKHINYWFASLELDERDSTRDVLDRLRPIVEANSLMPRLGRLFSMKEACSAFRSKAAAEGGSVVRVKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PJR1</accession>
    <name>A0A2X0PJR1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C028g10537 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C028g10537</name>
        <name evidence="2" type="ORF">BQ5605_C028G10537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000080">
        <property type="protein sequence ID" value="SGZ12944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PJR1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="414"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ12944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="691" mass="75452" checksum="82D258E0713576B8" modified="2018-09-12" version="1">MNGTPAPPPPPTSSAALATELNTICTRFGDILSRTSQIAAISGVSFYSQVQQELSQQSIQSLLVEEAPVIDSSSARSIKHELRSHHELNGDLPTSANELQRFWKRTMEDWIAQQLQARGDGPVTSAVSPTNFTDSSMQPTNDLKPQLLLDPSNNVTLGSSLLSLQPINPLNLGFSGTATPPFSPYTSPSPHRAMSASPIPGSASLSPFMPISPFVLQPSPFLSPFQFASYYAASMVPVPSQGLAMPMPSSSGSTTPLATQFGSLEVEESYPWSSRNIGYETNHNATTMTPMVQPPTPTPFDNSASTPDHSESPGARHLSSSSLPRLVTTDLSPPTGYTQSPTINISRSLTPDPSSLNDSGHSRTRSLSVSESPNPGGRVSHHRRLSSGSVRYHPFPTPPRGDSSPHLQGLNDHSLSAIITPSPSSLLSDLTSTTSNSPQSSNESASGAAPQKLVKKRRSRSADTRSRTTRSVQYDENAVFSTNSVDVFIVHTQTRSKSEVTEQDVLELELDSEPGANAVTSTLYRTVHSRLQYTYEMLEQDCEHRTPYHFDSSRAGAITKWIVSYDFRNPKVEEGQRQPRVRIEPVEPLSHLPSNSILTFVHFPRDSMVVDPTHPIGSSAWWRVQACEGRHEHCPGTGAWTARWDEEGSERRPSRIVQHYAACSLHKDEGDFFCLGKFARAIKRVVPHRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PKJ1</accession>
    <name>A0A2X0PKJ1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C020g09174 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C020g09174</name>
        <name evidence="7" type="ORF">BQ5605_C020G09174</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000082">
        <property type="protein sequence ID" value="SGZ18256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PKJ1"/>
    <dbReference type="STRING" id="796604.A0A2X0PKJ1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGZ18256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="510" mass="55985" checksum="DCC88F2C62F669B4" modified="2018-09-12" version="1">MQKDVIKMQHFEDRLPMHASDPAKLSSSINSSEPEKVVLTTFESCDGRDPTSLRAIAERKLVRKQDFVIIPLAVCLYLSAYLGSARLQGLEKEVLDNDDTKYSIALSCFFITYVVFSIPGTMLAKATSPSTSISIGALIWSIAASCQAAATSPTGFYVARLFVGIGEALFGQAMSFHLSLWYTKKELARRVGLFISAGATAGAFSGLIAYGVAHLENTSLQQWRILEGLPSLLLAITVFFCLPTRPATSKFLNEQERKLARLRLEEQSSFEVSCGIEWSGVRRAFKDWKTYVFAVMFSCMNLTLGSVGGFLPTIVKGLGYTAQNAQLLTVPPYLAALVCMLFLSTFSDRKQSRGLPVALVFGIGLVGWGLLYVIPAHGATYGQLHARYFACICIVMAGYSAIPIIVSWVSANTGNESQRVVALGMLNTIGQALAILAAFSFPSKQGPQYREGILINLSFQALGLLIALFLTLYFRLENRRRNELEGTPLYGTLLNTREEFDLATGFRYVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PKS4</accession>
    <name>A0A2X0PKS4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C021g09275 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C021g09275</name>
        <name evidence="4" type="ORF">BQ5605_C021G09275</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000083">
        <property type="protein sequence ID" value="SGZ20426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PKS4"/>
    <dbReference type="STRING" id="796604.A0A2X0PKS4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.20">
        <property type="entry name" value="Centromere DNA-binding protein complex CBF3 subunit, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038279">
        <property type="entry name" value="Ndc10_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031872">
        <property type="entry name" value="NDC10_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF134">
        <property type="entry name" value="RHO-TYPE GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16787">
        <property type="entry name" value="NDC10_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="719"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="56"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ20426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1153" mass="127602" checksum="D675EF28F19609E9" modified="2018-09-12" version="1">MQNVSSGPLDSPDLSPLPPFEADSQRNPYGLHSYEDTHRRGMNTPSLRTNAIEPASSISRSEYSSPRGYTSPSTSASPHSQSYFPAPGSTQPQSQPPPSQKHQHQVYNGSMSSPTHSYTAKPQYGPSHQSVSMHPEELEALTYPVTNAYRSRQPSGEAPSSDQVDPSQVSSAPIQYGYDASPGAHSSSPQRSPSYPSQQPPLQAYSTSPASSEQNRDYLQASSQTSDDLARTRSHSASSQGGSGMGEGLGLGSITESSYQANASESDRKPRSNYPKSPSGQMNTLGHGNNDTGALGQDDLAATGGFDEGVLKALCEMDCGMPLVLDRMKQCIASSHEASIFFKKRAQIEEEYAKAMIKLARSSSQAYGVSEGKAGTYVNSWIAMLRTHELVGDNHLKFAAQLAEMSDELALLGKEVDKNRKSSKELGTRLERGLAEQESLVDKARGRFDSAAEELERLLLLKQGESLKDNVVPHASTAPTSTSSNKRTFGKAMSKLKGPKNAAQVAKQEEDVRMRMGQSSDAYRSQVIGAQAVRQEYFNLQLPRILRVSTVGGVKSRRTNSADTSYHLVVRHSQSLKESTDEVDLGVQYHLSRYAYIFESTLVTDGLTVSPINPDDGPGLRAMADLIDIREDFKQYMQQYSVSWQMSGQRGPKRDGSTEDGFVSHRDVGFSRPEHSFLTSPLSMSRAQMASSRPVLTPRSSALATLQNYAAPILPTFGIDLGEQMARDGVEIPRVLVKCCEAIELHGLDSMGLYRLSGTTSRVQRLKLALDRDIEGTDLLSDEHLQDINDIAAVMKLWFRELPEPLLTWELYHGFIEAAKIENDRLRHIRLHERVNELPDPNYATLKFLMGHLDKVRQHESSNQMGCSNIAIVFGPNLLGAPPNEGGGSAIADMSRQCKCVETILQHYVEIFVVYAYLMSFVLFHHTQSVAFDTLFLVATYLEGSIYLLPTPSGKALAGFDGKFPERYYVARDIEANVPDDLQRLIFPWVREAALAEFEERFEADELCQDKALVGHLKLIQRFKLVILQNAAFLIQTYPDAPIYQTSLFQSDRFRTWAPHLVAMVYSGLLDSIVDRLGAQQSSERQSATAHFRSDNRRILELLIEQQNRGGHFHGHVRKRRLLEFVRASDRQITTIVIEVIEVAEKFGSSSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PL23</accession>
    <name>A0A2X0PL23_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C021g09395 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C021g09395</name>
        <name evidence="7" type="ORF">BQ5605_C021G09395</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAF10 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000083">
        <property type="protein sequence ID" value="SGZ21643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PL23"/>
    <dbReference type="STRING" id="796604.A0A2X0PL23"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07982">
        <property type="entry name" value="HFD_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003923">
        <property type="entry name" value="TAF10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03540">
        <property type="entry name" value="TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01443">
        <property type="entry name" value="TFIID30KDSUB"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGZ21643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="211" mass="22440" checksum="207964948AAE3DCF" modified="2018-09-12" version="1">MNPSAFVTTPTPSLSNWSQSSTSQATNVNGVGVGAGDSSSAPFGMDADPSLLASTSASTSDPTPFSNANDTTPSIGAPPATQPEPFEEFAPEPKTAKERAQDQRDVQLAELLEMMDEWQPIIPDEVTDYFLQKSGFETDDPRVKRLLALAAQRFVSSIAADSFQYARARTAASKSSGSKAKGRTRTVLTMDDLSAALKDYGVGADRAAYYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PM60</accession>
    <name>A0A2X0PM60_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C026g10243 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C026g10243</name>
        <name evidence="2" type="ORF">BQ5605_C026G10243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ27998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PM60"/>
    <dbReference type="STRING" id="796604.A0A2X0PM60"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706:SF2">
        <property type="entry name" value="RFEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706">
        <property type="entry name" value="SLR1338 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ27998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="519" mass="56771" checksum="52A4B5AE00F9CBAD" modified="2018-09-12" version="1">MAGGDVIAPQAGAGLLGKTATLDVCAYDQDRQGIWRLPAWWTSTCITPQLTYTPTLFPCHGDCSAPHRSLTTIRDSPPNSPPRDQAQPEELPLPQPNTVHPNYSTVLLPNNNNNTVRLSNNRLPRMVHLREVERRLMDHSRNRRVIRMLLLRVRHLQVIIDLRVTALLLHTDNTVSPSKDNTANLNRVNMASSSNMVSLSKGMDNSLSTVNLIKYGQAQQQQQQQQQPHHGGAAAGGGPDANAILATLSQCVVDQKITAFYPPGSLEPIAAKIAQSGALPRLAGEWNIPMEVAIDTAKLALFDTVLYCDDSGSMAFEEGGTRIDDLKVVISRCAYATSLFDFDGIQVRFMNSRVEGNGINSESGAMQLIENVKFSGLTPLGQALDEKVLQPLVLGPARAGRLQKPVVVIAVTDGIPSEPRDNITRVIINANSELVRTRYGSDAISYQFAQVGNDQKARAFLEELDKHPEIGDLIDTTSNYENEADDFARNNAGVELTPSLWLVKLLLGPIDSSYDTKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PN41</accession>
    <name>A0A2X0PN41_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C052g12580 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C052g12580</name>
        <name evidence="3" type="ORF">BQ5605_C052G12580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000099">
        <property type="protein sequence ID" value="SGZ29975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PN41"/>
    <dbReference type="STRING" id="796604.A0A2X0PN41"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17080">
        <property type="entry name" value="Ubl_SLD2_Esc2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad60/SUMO-like" evidence="2">
        <location>
            <begin position="714"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="682"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="436"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="689"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ29975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="789" mass="85787" checksum="78BA3A5823274BB0" modified="2018-09-12" version="1">MARRTSTLSTSTTSQVDVDSTSTSAGEATGRGRRIRKPTRRDDELVQTGTTRSALTAAAIGTAVQPLASRSTAGTTKVKKGRSRKVVVPPQEQQQPLIERPDVEDAHDSQPMVKSASIVAQQPVEIPNLIKPIVEVVLKPMHDTSPSSPPPPPPRSPLPVPVPVPVPVPVDIAPQPKQPVAPSSPPPLIKPTEVIILPATSSSQPDLQHTAVPQPKPKPIARAHLPPPPSQSHHHHHDSDSDEVDDFFMKRRTAPIASRAPHNSAAAGAKDRRAPMRRPGGGTLNHSVGLEPEAANAKAGPSTSKSPVRKYLSPRPSSTPPPLPSDYSESSSSSSSSDIEFIEDSGDPALEFGHRKINLPSWARQSSPGKIHGNKKRDRSISTVPPPLAEVKGKWKGKARAEQRDSSSDGFFIARDEDADDVGARKRKRKEGGRGYSPSSTGRSRSSSCSLTPPEEVSSEVLQQIIRAAHGELGASLAFNSSPSKDDERSRHSSVDSTDADLPSEMHELRSKHSLLAPTQDPTDAIAHSAHELDVVASSEMIVLVIRLAIEVDVTISASTTLWTQPWLMNLGSNAQFGEVFKSISRRYGVAEDDLVLTFRGRRVYRFGTPRSLKMCAGGEENELRVYRVELWEEVEELRRRRVGVEAEREKAVQDGRTRLDGEQLLLSEGDDQDEAELVGSNGQVSMRSSPLPDLPSSTTPAREPDSPDQDQLIRLTVRGGPKSSFGFAVKPTFLLRKVLAWYCKKEGIVDARRIAKMSLLWDGEKLDLEQTVADIDEFEDEDTLDVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PPT8</accession>
    <name>A0A2X0PPT8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C044g12159</name>
        <name evidence="12" type="ORF">BQ5605_C044G12159</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Clathrin-coated vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000114">
        <property type="protein sequence ID" value="SGZ31364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PPT8"/>
    <dbReference type="STRING" id="796604.A0A2X0PPT8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016482">
        <property type="term" value="P:cytosolic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14831">
        <property type="entry name" value="AP1_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000007">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044733">
        <property type="entry name" value="AP1_sigma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="11">
        <location>
            <begin position="25"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGZ31364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="184" mass="21144" checksum="213A2547BE9F3BC8" modified="2018-09-12" version="1">MHEDTDSLPNALHRSTQLHDRPNGISFLLLISRQGRVRLAKWYTTMSTRNKNKIIKDVTQLVLARRTRMCNFLEYKDSKVVYRRYASLFFVTGIGHSDNELITLEIIHRYVEVLDRYFGNVCELDLIFNFQKAYSILDELIIAGEMQESSKKSVLRAVGQSDSIEEAETSEDSLARLSSGHARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LPI6</accession>
    <name>A0A2X0LPI6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C011g06576 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C011g06576</name>
        <name evidence="3" type="ORF">BQ5605_C011G06576</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LPI6"/>
    <dbReference type="STRING" id="796604.A0A2X0LPI6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF94">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="2">
        <location>
            <begin position="288"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY12672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="540" mass="61462" checksum="1128F1B5839EDCE5" modified="2018-09-12" version="1">MYGSYLNKEHVKMIQQIYSTAEQDLRPCGPAVLQLFNSIKPLYIGHPPQDPQDQHLELEQITSSLIRLADERILSYHYKDVPTCWRQLHTDASLLQGILTVVSYMTDLTPEEQKSRFLKTIRQLDLVIIVAGAPGQGRYELVLDLIKRIQERYTKVRDDNQPRQSPAKRRKLSEDNRKEQAKARPRISPMVDHPIISLRSFPSFESYLELYHKEPFIVSGGSLDWPANELWCDQKYLQEKAGVGRCVPVEVGKEYTEREWRQEILPFEQVLNSVFEVSEYRPMTRVIHSDGQVTSRYNLPKPVHYLAQHDLFRQIPDLRNDILIPDIVYSAPPEGSKECPEYVSPKNEDGYVLNAWLGPKGTLSPAHTDPYYNCYGELDGQSSISAVVYATDQREASTAQVVGSKWIWVAPPSCSPAMSAFGLSSSTEDPTSDETEDDDQSPHHSHLLTNTSRIDVSSPDTYDAAFKEQVVPFAQQAVLQKGDVLVLPPGWWHSLKGLEIALLLAWKLDFKWGIVRAEVSPNNLYCPMGNCTFRPVHKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LSP4</accession>
    <name>A0A2X0LSP4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C011g06541 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C011g06541</name>
        <name evidence="1" type="ORF">BQ5605_C011G06541</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LSP4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY12565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="115" mass="12640" checksum="6D8164A8479CA7F7" modified="2018-09-12" version="1">MDAQIERAFDVPKDTFDGLEMRCPRFANKPREIPHSVCKIGLGGNNGVHEGADHRMIHRVVGFIGVDLGQQLEVGLHWRFAGIAIGHAKTSQHVDKVLALQEGDPAIIMPDNLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LTD1</accession>
    <name>A0A2X0LTD1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C015g07823</name>
        <name evidence="4" type="ORF">BQ5605_C015G07823</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LTD1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="422"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="3">
        <location>
            <begin position="722"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY17572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="889" mass="99825" checksum="08F7B8F3C80B9F84" modified="2018-09-12" version="1">MLHGKCGGNSTQPCMEKDKYGNPRCKRHFPREQNPRTRMHPDGYPLYRRRFRHAVVKGGVIYNDGDCVPYSPYLSAEYNAHINVEAVITIGAIKYLFKYVYKGPDRAVARVERAANGEGTREDEPVRDETNDFVEGRYISAPEAVHRLFGFSTGRVWPPVNRLPVHLEHQQSVQINPDEPLPLDTPPTRSKSTGFFDLCAAAPDGELTATLLYTNVPRYYSWNKEKLRWKRRVRDRNVIGRIYTVPLRSGERFYLRLLLEVVMGPTSFADLLKFEDVVYPSYRAACAARGLLADDGEHHICLWEAAQIRTGDQLRRLFVFMLIHATVANLPALLDRHFDSLSDDARYHIENYEDVPLTEDEVQLFDRPDDRLPRFDREQCAQDAEEARARLNHDQRIAFDEFLRAVELDVVDQMRDDNLGPQHVFFLLAPGGTGKTFVENALLDTVRARGDQAIAVASSGVAALLLKGGHTAHSTFRIPLDTSPTLTCPVDRESDLALMLRTTKLIIWDEAPMAHRFAVEAVDRLLRDLRETEELFGGVTTVFAGDFRQCLPVVPKGTPGQIVDASLIKADFWRNVRVLRLTENMRLSSNADAMGEAQLARTRDFAEWLLNVGDDLPTCTHTTRSPYLPDYLLLPDGQRTAEGLINFVYPGLRTVNKESLDDLIQLFSRQAILAPHNATVDHINAKLFEEFDGDYVEYRSADEVVEAGEAGGGMAPELISPEYLHSINPSNFPAHHLRFKEGIPVVLLRNLDPDAGLCNGTRLIVSHARSRVIQAIILTGDRAGTTVFIPRVRLETNATSSRQLGFIMCWLQFPLRVALAMTSTKPKVNHLIVLASISPCIPVDRIKVLLPSRDPADDDDDLQAVDRAAAAATATPNPVFRSVLRAMNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LTK6</accession>
    <name>A0A2X0LTK6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 14">Phosphatidylethanolamine N-methyltransferase</fullName>
            <shortName evidence="13">PE methyltransferase</shortName>
            <shortName evidence="13 14">PEAMT</shortName>
            <shortName evidence="13">PEMT</shortName>
            <ecNumber evidence="13 14">2.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BQ5605_C011g06460</name>
        <name evidence="16" type="ORF">BQ5605_C011G06460</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13 14">Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11164"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64573"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="2.1.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="13 14">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13 14">Endoplasmic reticulum membrane</location>
            <topology evidence="13 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13 14">Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13 14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.17" evidence="13 14"/>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LTK6"/>
    <dbReference type="STRING" id="796604.A0A2X0LTK6"/>
    <dbReference type="UniPathway" id="UPA00753"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004608">
        <property type="term" value="F:phosphatidylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03217">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016219">
        <property type="entry name" value="Phosphatid-EA_MeTrfase_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138:SF0">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000383">
        <property type="entry name" value="PEAMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51598">
        <property type="entry name" value="SAM_CHO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 13 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 13 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 13 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11 13 14" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="12 13 14" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 13 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="230"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="298"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="464"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="391"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="962"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="368"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="401"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SGY12303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1051" mass="117894" checksum="234660C80B0E4189" modified="2018-09-12" version="1">MSRDHVQDPSGLRRRAPGGTTDVAPTATTTTTTTTPKTVQPSQAVNPTQSSDSDKSHAPLGKTPDGKVFRIPQTHDMLSSLFDPRLPKSHIDLLTLFLLAAQVVLFLSLPLARSRYFFLGYFALWRLAYDCGLGVVLKRQSEHRWIVRTVLRRGWMDLSRRPRVHRWVTSELKAKMGADYAFDAVPIEFNVWIMFRHFVDVILLNDFLSYFFFALSFLQTPPGHSTAFHVLRWIGGVTLILFNLWVKVDAHRIVKDYAWYWGDAFFLSLQELVFDGVFEFAPHPMYSVGYAGYYGLSLLVASQTVLVVSILAHACQFGFLVYFENPHIERTYGQRKPLAARTAQAPISGPTVSLLRAVSPHVADGPITESSTPDLTDHASTGSESEFEAAPAFSASRAGHSPNQQGQPPEASSSPQYGGSLDPTLEPTVRRRRVVATRHDLDNHYFRNDLLIFKNLDVFRNRDLAFLLVVFYGAVVVFMPPLCPQAQISLACMHTLAWRCFHSFGLGSALKAQSERKWIVRHFLKHYHYEVEGEAVDDAFKNWKATYNMSLCMSYASFGALAWQCYSLPVDWTVGAQLVRHVLGISLVALHLWTTQSTLEVLGPFGWFYGDFFIQDYPHELYYTGIFRFLNNPERSMGGAAFFGMVLISGSKLLLSQAVIAVAAHWWFLSVVENPHMRRLYGNTLRQDAGVTKTIRGVAARNAHVFGGVSQSVREVQGSFEKVLDETADVLEDFLNRSGPIVKGYVNETKVLLKQTSERLVISRVAHDLDEYDASKYGLKLSAPQSRSLRPSGGTRGDIPSFHLGQVIRVQWQAPLNHSRKDWIGIYCQGANQSQLVTRISSHGRWLGVHEHEWRGDKYEGTNGPGTEDSKDLKHEVASGSVTFSGARLPWSTGSYEIRYHHDGKHSVMARAEPVNIYVEEPNDANDPQEIYKTLTVIVAHALASDPAARPKSASRLLEFDDNPFQNNTASSEPFRGPNDNSRPELVFSDKDDFAIYSVADAKHIAYAIREAFEVELTSEVIMAAANVMRLANRIVEARKVLLATKADDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LV09</accession>
    <name>A0A2X0LV09_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C013g07071 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C013g07071</name>
        <name evidence="3" type="ORF">BQ5605_C013G07071</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY14738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="746"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY14738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1539" mass="170070" checksum="B3EC1E243C4717C0" modified="2018-09-12" version="1">MVRSFALVKIYGMAREGRSLVSGQYPRVKARLVSLFWIAFLSAPTAQQPALEIQPREDIRRCRVAGKNGKHGGPAALNSRASGTNMIQLGPRANPAGAATGNKDDANDDDGGGESVASTEPEGGDTGKETLTRATTGPTKETQTTTAAPVSTPTSPSPSASAPASPLSGGTSESSATSTTSIASTSPRRLRSSSAPGNRRVTRAGSAMILGASGGDGSGGNSSGVNQVKIIRYLKTLRPAPAAILLQEHHLSYNALREGFESAWPGACIRFTPHVLTLIPDGSPLAGHLLSSTPVVFAGAPRLDGRILRSVFRLEELDVEIINMYAPVQEDDRRDFFGLLHFNAPRPKTLRILAGDLNDCPDVSVDRVSITDRAWTPVSHWQTLLSKIAFNALDTVRHVHSCTPAFTRPHYRGRGEERKICSWSRIDYILVQCSWANRLLSASTLFDAPCSDHRPVVATFALPTSNADAEPPLSLPSTSDFISRLNPTVFDDQDFVASIPGVVDEVYRRLEGTAPLGDVYDAALRAVAVAGHARYRSTRADMRRLRAESQSVMEALEARGEHMNEAERDAYAFAKSRLDQLAVKEAQWLRIRAHVPSVDSREGQSASIRTRLNRRSRQTSIVSLEDVDGTETVDMQEALGIASRHAQSLFTPDPARGDPTNARRSLLDPIRAAKCYDDDRSDPTFGRRLPRQARVALDEPFTLLEVEAALKKTDSGRSPGPSGIPYELFKALPTYFAPKLLDLFNSIWEGGKMTASLAEGLVRLLPKNKPGANLKSLGAYRPITLRETTYKVLSKVLVARLNGVLGELLPPAQHGFMPSRRSADAGSHLTLLLEKLKSLGTEVFPEGALLSLDQQSAYDRVDHAWIFDVFEAFGFGERFISLLRALYDPETLGVRYLINGFPTELVRLLCGLGQGDPLSCPVWNITFQPFLDALVRRGIALDLQKVWPGGPRAQLTHLAFADDAVVVVESPAALSKLETLSQTWYEATNGKTNTDKTLVLPLGPNWLRDETAQALPTVQEGESFKWCGYAFFRHGDSKLFWTHVLDRIKAKTRAAGDRTLSPSGKVFYANAHIISTVLHVLSFDIPPQWFIKAAETALTDFVWGGAGRNTVARDFVFQAREDGGLGLISIGDIVHSVALRFWDAVAGSNEAIWAPLARESWRSLVAATRDFSPWGFFSSTARVEKLYRDSTRWGAVVAAARVTVPTIKSELLTLPELLSLPPRLPSLYAEGAKHAYDDADAVAKFAQIADLYWRDEGKGWALVGHRRGFWQHSKEPALQHEHVWSRVGQLLKAKALLPKTALRPARIPLKEAPRPRCFNFLGLTRPFTIRKLRRLVNVVRFPGREDRVKRFRDGTSQSDRKRFWRWLHDRFASAVEQDTHWRLMYDVTPTRKRQHTQGHASSPTCLFCGNDAAVIETVSHYFFECAYSTSFWGGVLRILFDKLGIEDTDVDPSTFTPEQLTMGLPLLRGRGRTTSRWMWVRLACAIGFQRLHLLRWRVHQWFELDKVVAPPSLPSALRAFERDFLSRAGFVPGARDWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LV19</accession>
    <name>A0A2X0LV19_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C017g08480 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C017g08480</name>
        <name evidence="1" type="ORF">BQ5605_C017G08480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY20129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LV19"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY20129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="145" mass="15614" checksum="57CD04D22ED2BAD8" modified="2018-09-12" version="1">MERVRSVCLGQSAGNGNPTVFVLCLAIVDIQLYPDQLAHDNVYSPRLCSITSIISLIPAPEGCTSKAIVATLRLVVATEGFNAVVLGSKGRGQVPSQSCSKYGTRGKQCRWAGPGTVTNAIVIGTQIRKRVRWETPLMRKADFPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LVE7</accession>
    <name>A0A2X0LVE7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C013g07221 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C013g07221</name>
        <name evidence="2" type="ORF">BQ5605_C013G07221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LVE7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY15043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="133" mass="14816" checksum="28B3A7D840100FB5" modified="2018-09-12" version="1">MQWRVGLEARAIRVHESCRRIAGIGDGHAGSLEKRDQRYQRRPELQLILPQEHRLPSHISEGAHCPSFTFTPNSSHAKQHQGGGETQPLVATGDLNVLKELKRRRKCSTPTHVLAKGSASDPRSAVPMVQLEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LVG6</accession>
    <name>A0A2X0LVG6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Complex I-ESSS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">NADH-ubiquinone oxidoreductase ESSS subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">BQ5605_C013g07241</name>
        <name evidence="19" type="ORF">BQ5605_C013G07241</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Complex I is composed of 45 different subunits. Interacts with BCAP31.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB11 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LVG6"/>
    <dbReference type="STRING" id="796604.A0A2X0LVG6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019329">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ESSS_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40637">
        <property type="entry name" value="ESSS SUBUNIT OF NADH:UBIQUINONE OXIDOREDUCTASE (COMPLEX I) PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40637:SF1">
        <property type="entry name" value="ESSS SUBUNIT OF NADH:UBIQUINONE OXIDOREDUCTASE (COMPLEX I) PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10183">
        <property type="entry name" value="ESSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="20"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="SGY15086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="149" mass="16378" checksum="245B853F05E209A2" modified="2018-09-12" version="1">MSRLLMTRALTPMLRSTPKAMMGARSASGGQQYNPPTGYLFGEKAGQRQLSNRGEEPGKDSDKPPVLTPNIAWLPISTGQKRVREDWELIFYWGFGGGIALAAVLKFYQPDTSLEEWARKEAKAKMAAAGETVSRLDLSRMGKAVEGMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LVR8</accession>
    <name>A0A2X0LVR8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Lon protease homolog, mitochondrial</fullName>
            <ecNumber evidence="11">3.4.21.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BQ5605_C012g06813</name>
        <name evidence="11" type="synonym">PIM1</name>
        <name evidence="16" type="ORF">BQ5605_C012G06813</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homohexamer or homoheptamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="11"/>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LVR8"/>
    <dbReference type="STRING" id="796604.A0A2X0LVR8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070407">
        <property type="term" value="P:oxidation-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19500">
        <property type="entry name" value="RecA-like_Lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000021">
        <property type="entry name" value="Lon protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000019">
        <property type="entry name" value="Lon protease homolog 2, peroxisomal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.5270:FF:000001">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1480:FF:000003">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.40:FF:000010">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03120">
        <property type="entry name" value="lonm_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054594">
        <property type="entry name" value="Lon_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027503">
        <property type="entry name" value="Lonm_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718">
        <property type="entry name" value="LON PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718:SF2">
        <property type="entry name" value="LON PROTEASE HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22667">
        <property type="entry name" value="Lon_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 11 12" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="15">
        <location>
            <begin position="208"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="14">
        <location>
            <begin position="979"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="311"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="367"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="875"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="132"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="370"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="878"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="901"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="922"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="active site" evidence="11 12">
        <location>
            <position position="1070"/>
        </location>
    </feature>
    <feature type="active site" evidence="11 12">
        <location>
            <position position="1113"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="662"/>
            <end position="669"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SGY16232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1188" mass="127930" checksum="7A71E2E5C958A633" modified="2018-09-12" version="1">MLPSRSWAAAGPSTRSLALSSSRWSTSTPRMARTSTLSAPRHLSRAVGTSCSSLAPISRSSSSSSSLHLPRRPFSTSVDRLALLSSTTPRLYPGRQGGGRNGGKNGAEKLSAEPENEETEVDDNPESTPSPTNDNNNKTSKASSSSTSASSSSSSSEGSDSAEASTPPSLSSSSSSSDDGDNGKGSDSTPPSSTSLSKRTVPEVYPQLLALPITRRPLFPGFYKAVVIRNAAVIAAIKDAVARGQPYIGAFLLKDENADSDIITDSNAVHPVGVFAQITSTFVAAANDKDKNEEPGLTAVLYPHRRIRITDLLPVPQNTPPSAPEQSKVTEDGEQVVPKEADAAAPVDQSARTDQTADLEKIIEASYQHGKKDDAAPSKSGEDSTASSTDPSSGSFQTAFLHDYAVSIVNVENVVMQPWDKKSQTARAIASEIIAVFKDIASLNPLFRDQIANFSMSQSAGNVFEEPDKLADFAAAVSTGEINELQDVLESTLLEERMQKALLVLKKELMNAQLQSKISKDVENKIQKRQREYYLMEQLKGIKKELGIESDGKDKLVDKFQSKADTLNMPEAVRKVFDEEINKLSHLEPAASEFNVTRNYLDWLTQIPWGRHSQENFDLVHAVQVLDEDHYGLKDVKDRILEFLAVGKLRGTVEGKILCLVGPPGVGKTSIGKSIARALDRQFYRFSVGGLGDVAEIKGHRRTYVGAMPGKMIQALKKVQTENPLILIDEVDKIGRGHNGDPASALLEMLDPEQNAQFLDHYLDVPVDLSRVLFVCTANTLDTIPAPLLDRMEVLEVSGYITEEKAAIASRYLAPQAKDGAGLKVADVELTEDAVAALIRYYCRESGVRRLKQQIEKVYRKAALKIVQDIGERSLPESSAEVVPPPNASASAPASTVVSSGKDKSTFPIIEDKVQKEDGKAAEAGTESASTTGEERTTTTGVRKPLDVPESVHVRITADNLLEYVGPPMYQKERMYTKSSPVGVSCGLGYLGNGSGAVMPIEVTTMPGSGIQLTGKLGDVIKESAQIALSFLKSRAFDLGLTPDADHDLLSKRAIHLHMPEGSIGKEGPSAGIAILTAFVSLFSKRGIRADLAMTGEMTLAGQVLPVGGLKEKILAAHRAGIKKIIAPEACRADIEHNVPESVKEGIEIVYVENVAQVIREAFEGHPIVDRLEGLSELLRPKVVEEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LWG1</accession>
    <name>A0A2X0LWG1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphopyruvate hydratase</fullName>
            <ecNumber evidence="3">4.2.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C012g06904</name>
        <name evidence="13" type="ORF">BQ5605_C012G06904</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(2R)-2-phosphoglycerate = phosphoenolpyruvate + H2O</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Mg(2+) is required for catalysis and for stabilizing the dimer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="3"/>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LWG1"/>
    <dbReference type="STRING" id="796604.A0A2X0LWG1"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.10:FF:000001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000002">
        <property type="entry name" value="Enolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902:SF1">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00178">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enolase N-terminal" evidence="12">
        <location>
            <begin position="3"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase C-terminal TIM barrel" evidence="11">
        <location>
            <begin position="143"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="384"/>
            <end position="387"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGY16549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="455" mass="48693" checksum="121FB7AD96D34083" modified="2018-09-12" version="1">MAITKIFGRQVWDSRGNPTVEVDVHTEKGLFRGTVPSGASTGIHEAVELRDGDKSKYGGKGVHKAVANVNDVIAPALIKENIDITDQKKIDEFLIQLDGTPNKGKLGANAILGVSIAVAKAAAAEKGVPLYQHFAELAGVKPPYILPVPAFNVINGGSHAGNALAFQEFMLLPVGAKDFNEAMQMGTETYHGTRNGTNVLKAVIKKKYGQDGELVSTVNVGDEGGFAPNVQGAEDSLELLKEAIEKAGYTGKVKIGLDVASSEFYKDGKYDLDFKNPNSDPSKWLTGVQLSEVYSKMVQDYDIISIEDPFDQDDWEAWSHLRANSPIQIVGDDLTVTNPIRIKTAIEKKACNGLLLKVNQIGTITESIAAAQLSQSDGWGVMVSHRSGETEDTTIADLVVGLGVGQIKTGAPCRSERVAKYNRLIQIYEEIGSSAQFAGDKGLSSGPNPAPLAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LYZ6</accession>
    <name>A0A2X0LYZ6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C017g08545 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C017g08545</name>
        <name evidence="2" type="ORF">BQ5605_C017G08545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY20241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LYZ6"/>
    <dbReference type="STRING" id="796604.A0A2X0LYZ6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058353">
        <property type="entry name" value="DUF8040"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF221">
        <property type="entry name" value="NUCLEASE HARBI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26138">
        <property type="entry name" value="DUF8040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8040" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY20241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="178" mass="20224" checksum="72D72107E5B2A0AD" modified="2018-09-12" version="1">MTPACFSIFVKKVHLHTEIVPSKHVTVEEKLAMLLYWLRGAKSYRKIDEVFQSSAFLLTPSLSASTRAPSYLRRSHLPETLGLLVHSDLRKLYVVQPTADTPTSSVITDKPRFVRYFGNCIGAIDGTHALYKTQDILAAMTFDLRFCYLQTGCEGSAHDQQAWDWARERDLLIPEGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M0W1</accession>
    <name>A0A2X0M0W1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C018g08768 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C018g08768</name>
        <name evidence="1" type="ORF">BQ5605_C018G08768</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY26743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M0W1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY26743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="356" mass="38673" checksum="3E40F44BCAA1457C" modified="2018-09-12" version="1">MYQHTVVSAAPACGIHVPIRSHVPALCQLFYFLCQLNKATAFPGGPSQPRLGRKGSTVPWACSSARCWAPRGSTLLFVPRRSTETAPLAVVSAMANSTLGSPHHHLFRKGGCAGLELRSNPSSPTFQYATTSARTAVCTHCKARHWECERSKSTRHFSACCSQGKLLEGSDNAKASRQNARSYNNALSFTSLAAHCWDQTQVDTIGPPVFRVFETHIQRSTLTKLQSMLRTGNCFVREFASAKARAGWDTAKEWVLRLCLPPGRDSVGAFFTQLPKGHSQEMILYNTAVTHHVINDPAAFADLKATAPSLLKGINGEGKTIMGVGMACVEDKNSKRYNLVNSIFVPSAPANLFAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M1K9</accession>
    <name>A0A2X0M1K9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C002g01072 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C002g01072</name>
        <name evidence="3" type="ORF">BQ5605_C002G01072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY29640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M1K9"/>
    <dbReference type="STRING" id="796604.A0A2X0M1K9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037508">
        <property type="entry name" value="Msb1/Mug8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012965">
        <property type="entry name" value="Msb1/Mug8_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28093">
        <property type="entry name" value="MORPHOGENESIS-RELATED PROTEIN MSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28093:SF1">
        <property type="entry name" value="MORPHOGENESIS-RELATED PROTEIN MSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08101">
        <property type="entry name" value="Msb1-Mug8_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Meiotically up-regulated protein Msb1/Mug8" evidence="2">
        <location>
            <begin position="150"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="794"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="852"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="949"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1084"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="977"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1084"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1120"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1137"/>
            <end position="1146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY29640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1167" mass="125971" checksum="B6136B025C43AD4A" modified="2018-09-12" version="1">MKKVFGRKKSATKLGAGSGGNGSDPSYHSQAAPPPSVGHGHSSNSLAVGHASTSRATGGKRSTESAMTLYSDHSKKHVDDFGRPIDHRPAFGKDSLGLATHGSGHGATGAPNSPGLPSYAADDDPNAGGGDSDMQLLFGYTPIETLLELSVERVLEVVVKCSEQIRARGVDTPLILSSMSLDLTMEGTCSLIRSYLADPSAWTFDLTLASPLCVGAQMKWALARLINDRGGRGFVSWDLYDDFKHSEKAAGYPPRHCSTHLIARLATSSAKLLTEILSLFSSISAHSKTNGMPPRKLASLFSPYIFGLADDETFDATYEQWQRLTDATEHILLSYIRYQQAAEGALPTHLEKHIIGYPQTVNINYSNRRGVSRLATGARVEEVVRIRRLTRFHSRNLIASAGTWSVPNSSDWALLFPPGYRNKTLAAPSSVNPPATQYTPHFRHLLNIRGNNLFDDEDDDGELQRYKSTVEKDWSKFGELGFKDVEAGKLEFDLTESERTAPIQKRDTMDWGTFASSGFGGRESFKPNDLIFHQSINNRVNTWPASQQALDTKLRAAEKMLPAFPYDTTPREEARVVVDALFFEAWADVLVSGGWARDELKESSFALIHWKSRPRDGERPKGRPSASGDDRTEDRWVLVEEFVPKEYRDELTDGKVSVSYSGCARYSALPANILTRNTPFPLQQKKQSKRISFMRSVRKKTSKTALPRIQQPMPVTSMSLVAPPISSSYARTSSPMRTIDESVFNPGATTPTKTVSLSRSDIERATIAGSTYAPSFTTTVGPTRGHGQAYSGMPTTHEEGRYSTDAPRSSIGAYGPTDFDPSQDPRTPTMMDMPPPVPAVVSDGTRLHGLGVIHSQASPAPRDGASAPAWSRDRDRSGSVSSLAGGDATEPPRQAKLTSGSGGGAKGFLSRMTSRNKKPSPAPLPPHSPTYQSSAPAGRVMPLTAAALAQHSPPPPMGSSRLGDNGGVPGGPEVIVQSPTVRTLMQRSGSSGIPPPLPPKTPDGHTIDEGEFDPSQRSNVRDSVMTTATMMTTGTDAYGGIESIEEEGQVGQVMYRGSDVNSSEGEPSPRRVMLSDVVGGTSTFENQQQQPSGLVASTLQRHESLPPSSKPDAEVPVDVSRNSKFMSGTPSQLRGVGPMGTPGGRVGKMVGRIEEGNEGVRLTQYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M3H0</accession>
    <name>A0A2X0M3H0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C003g01824 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">BQ5605_C099g13113 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">BQ5605_C099g13117 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">BQ5605_C099g13121 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">BQ5605_C122g13309 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C003g01824</name>
        <name evidence="2" type="synonym">BQ5605_C099g13113</name>
        <name evidence="3" type="synonym">BQ5605_C099g13117</name>
        <name evidence="4" type="synonym">BQ5605_C099g13121</name>
        <name evidence="5" type="synonym">BQ5605_C122g13309</name>
        <name evidence="6" type="ORF">BQ5605_C003G01824</name>
        <name evidence="2" type="ORF">BQ5605_C099G13113</name>
        <name evidence="3" type="ORF">BQ5605_C099G13117</name>
        <name evidence="4" type="ORF">BQ5605_C099G13121</name>
        <name evidence="5" type="ORF">BQ5605_C122G13309</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000001">
        <property type="protein sequence ID" value="SGY11462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000001">
        <property type="protein sequence ID" value="SGY11468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000001">
        <property type="protein sequence ID" value="SGY11482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000030">
        <property type="protein sequence ID" value="SGY27891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY37473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M3H0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY11462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY11468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY11482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY27891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY37473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="53" mass="5362" checksum="D30EB480F818DC9D" modified="2018-09-12" version="1">MSLISGPSNVQDTEALLGTKPEPADAGRAGLTVSIIELQAGPDASTGLLKLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M3Z6</accession>
    <name>A0A2X0M3Z6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C002g01740 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C002g01740</name>
        <name evidence="8" type="ORF">BQ5605_C002G01740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY35207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M3Z6"/>
    <dbReference type="STRING" id="796604.A0A2X0M3Z6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="467"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="510"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="121"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="364"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY35207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="537" mass="58310" checksum="F91C485990A58DE5" modified="2018-09-12" version="1">MPPDHTTVNALFAVPCRSPLAATQWITRGLETPIMATRGGFTHSDKVANLILSTVVSDCAPRPLPLLSTAGCCCMFGAAQHPTKFHADSRGATYLLPRECVAEPGFPVILSTHPQSLLGSASIIIGYIVSFSSGQNRLRQRIVLGLGVVDFIVALTVVVGTSLSLSGRTLGTNSAACDTFGFFYQACTIVSAVWTVMIALVTYTTLVHPLSTFTTALEKRGASWVLLGLAYAIGIAPSIVGAVSSPIIYGIQIVWNMVDLGGICFYDPRSLEAKIMLFIPRGIAMLMTIGIYIALFIFFQRRDLSIFENTMSSIADEEEEESAIVDPGFGRRFSSLVSCNPRSSDMTQIRRHSLAPLPEEHLSTQRPSVGSEDTTVAPSTRDSSAIIIALPPSSASHSANDCSPDNEQVPFDRPIPSTKLQTPVCAEASMLNPNYRFGSQSEAAESPIQTPDKVPRKLSARQLNRRLSLLMSLYPLAYLVLFSVSVARVITQLVTKDFVTPEFAKVSRWLVLAQGFVDGILYLVIELLFRRSVRSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M405</accession>
    <name>A0A2X0M405_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C002g01750 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C002g01750</name>
        <name evidence="7" type="ORF">BQ5605_C002G01750</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY35305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M405"/>
    <dbReference type="STRING" id="796604.A0A2X0M405"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013907">
        <property type="entry name" value="Sds3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01401">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="213"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="418"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="422"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY35305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="442" mass="47414" checksum="5303783CE31007E3" modified="2018-09-12" version="1">MWRREPSPQLQASSSLGPLPPLPETAPPHGAMYDDPYAAQHVAAQQQQQQGQGQPGQALDVYGMPIESKRDKRRRDMVERVARLHEDTIARRDRVFHELSDIFARTTEELLPPPVFPNAGDPSAPVETLPPSLACTDPVIPDMHPTQFLFGLHRLSMERSNQLVATRLFHAHQKTVARKLYEAEVERIEEEYESAAKGVVERLLEGVEERRRRLTEEKDGEGVTLGTHTFLDPQARSHGTRRMRGIPSSSSRRALFSSLDSSDVSGAGASGDGANGAGPSSAVANGLGGISSTHMHSLLSFNGVQDPFHLAQAFLPHPNHPTSHPLLSSLAASSTMLVGGSMGLLPGSASNAASTLSGGGGHSMKRKSGVPRAQPGLPPTNFTVAVGVYAFQNKCQPGLSSLRVDEIELDLGEVRRKKARTGTGGANGTGGGGRGRRREEVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M481</accession>
    <name>A0A2X0M481_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C001g00733 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C001g00733</name>
        <name evidence="4" type="ORF">BQ5605_C001G00733</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY49059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M481"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070290">
        <property type="term" value="F:N-acylphosphatidylethanolamine-specific phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070291">
        <property type="term" value="P:N-acylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032:SF35">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="3">
        <location>
            <begin position="268"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY49059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="533" mass="60119" checksum="904DA128CB72BAE7" modified="2018-09-12" version="1">MRVVFPFLSGWVKAIGLVFLGVPVVYYTYVELFRAREIRRRRVQYHSKRQRRLERIVANEGDNVGALASSTEEVTKREKEGSEGSEGVSVGKERRGISEEEYEEIAEMYAPYVLGGRYCNALGPEWREQGAWEWIAWKLIWAPLHGTLFWNAGVPTDPIKLAESLPLERPNFELLFGFDPEQVSVDTAPPEPTAKETSDARLAESIGDLSASWDRLSSSTPASLSSATSQRVSRSNSETPPRVEVGEDLTATWIGQSTTFFQLDGVSVLTDPVFAHRTVDTVLAPPRLCPPPCPLSALLSIQLVLVSHDHFDHVHPDDVRYLGNSVHWVVPTGMGKFLRSLGVTRFSELTWWQTTVLEFTVPLRGGRTESRKLNITATPAQHWSSRGPLDTNQSLWCSYVVEGKHETVFHAGDTGYNATLFKAIGKVFGPFDLALLPIGSYTPRWHMISQHCNPEDAVKICLDLGAKKAWAQHWGTWILSDEHYLEPPKMLELARKKWDFQEGRFEVVRPGRTGCWKRVESKEGEDEDEDEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M508</accession>
    <name>A0A2X0M508_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g03776 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g03776</name>
        <name evidence="2" type="ORF">BQ5605_C006G03776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY53581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M508"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="1">
        <location>
            <begin position="249"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY53581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="517" mass="58378" checksum="75D76E07893A2FBE" modified="2018-09-12" version="1">MADPTLSLPHHHLFLRRGKCAGLKSSSNHSSPTTCCLQGKVQLPPLSGPIPSINSYLKARIPALKDPACFGYFDAFTIDSAHSWRPESCRQSAPNLCQNMAHLPGRGHRHSTWTRRRRQPKTRKWRCLSAIPTPTLEIVDHKTLFSRCTVINVPMIGPSTKLLACSIRLQCLSVTHYSSPQRKIASTSTFLFAHSTKLGHSLPKDRDKEEGDAENGDGEHKPLRLFLGCSILLRRTHRLTLNRSQLFAYDLHKRDKYFSIPHCTQRAFLAFVMTDTPRSRPIDSTYLQLDQENLRLTTGQGIISLTPDQVGCLVILGSMFKNRPRENTQRYQDAMVCVVKYGKPSLFITVTRNPEWPEIKAALGPNDQACNRPELIARAFEAKLNRLCDNNVFGNKQRAGCLADEWRTFSLLYFVFCTLFGPKMSKFHMRLGNIIKMCSTCSKNHSKVLENVFPAFAGARRLIKSGLRRALLRLVSCMAPGITQAFLALLLASLFRCQTSVWLNLSSLYPWRHLCGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M554</accession>
    <name>A0A2X0M554_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g02152 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C003g02152</name>
        <name evidence="1" type="ORF">BQ5605_C003G02152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M554"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY39129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="99" mass="11107" checksum="84D1D7B73B3DE201" modified="2018-09-12" version="1">MPSPEAAARNRSRRRRANWFVKSTCTGSRQSQCRTASATGPQFFTSKLDIRFSIFLPPALHTLPIAPHPIATSSSRHPKRSSWKLCNEYGIKKCLPHAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M657</accession>
    <name>A0A2X0M657_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00219 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00219</name>
        <name evidence="2" type="ORF">BQ5605_C001G00219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY44931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M657"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY44931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="196" mass="21065" checksum="0A7A443EC5DA3008" modified="2018-09-12" version="1">MVQAAPASSPAAQPADLALRTVHVDDSDENISPSWSRRIVLVQAEATEEGEWEEGEMASQPSLSPVSARPIELPSRDGPRVLSSDRGNMPSQGGATHQPKSRPISPASIWTFELRGAGSDLAAYQPDYRDFPDPATPLTPTHRSARAPELSRAVSVSRLALIFSITTTSKGVSFSSKAYKASTGVLVDDDRIRNRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M756</accession>
    <name>A0A2X0M756_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C001g00589 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C001g00589</name>
        <name evidence="6" type="ORF">BQ5605_C001G00589</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY47905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M756"/>
    <dbReference type="STRING" id="796604.A0A2X0M756"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_uL15_bac-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934:SF11">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="5">
        <location>
            <begin position="113"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="39"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY47905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="277" mass="30007" checksum="BF706368B79F0B21" modified="2018-09-12" version="1">MTSLHHLLKSLTLSTPSPRLIGSCSSPLVARSYATASTSHLGNLSPAPGSTHKRKRVGRGIGSGRGGTSGRGHKGQGARSGNGKPALHFAGGQTPLTRAYPKRGFTNTQEWTPLNLDRLQHWIDRGLIDPSRPITMSELKRSKCVHGIKHGVKLLGDRSRRLISPYTEPSSQGADKWNTPNVNIVVSRASQSAIKAIESLNGTLVARYENRLTLRALLNPDSFHKKGLPLPGKADPIKRTDLLFYSDAEKNRGYLGLMARAKKEATKETAAEDLVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M7Z7</accession>
    <name>A0A2X0M7Z7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C001g00939 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C001g00939</name>
        <name evidence="5" type="ORF">BQ5605_C001G00939</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY50924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M7Z7"/>
    <dbReference type="STRING" id="796604.A0A2X0M7Z7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF19">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="4">
        <location>
            <begin position="148"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY50924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="356" mass="39717" checksum="465E8E00930A48CD" modified="2018-09-12" version="1">MPTLSTVGVAVHTAPAGLRGFVQFLLHHRKLKKDGSPRAQLSYGEGLNIVKKFLLYASTHPLGELQKFTAHHVTVPRFVSRKVVTISDECISRATHLLVKALSVDPKTIEQVGGVKWWTMRGRPLTAEWIEMRKYKIARGDRSPERILFYIHGGAHFFSSLETHRYQIQRHARKLNGVAFAPSFRLAPQYPFPCALLDVLAAYLELLQTPGVDPSMVVFAGDSSGAGLTLVLLTLLRDLELPMPCGATLISPWVDLAHSFPSIIESDAGDYIPSDGFHYKPSLVWPPLKTPEDFYVLEGEEKQILLDEQMQMYCPNAMLRHPMVSPVNQGSLGGLPPLHIVRPRTLPPMRVKTSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M842</accession>
    <name>A0A2X0M842_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00687 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00687</name>
        <name evidence="2" type="ORF">BQ5605_C001G00687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY48733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M842"/>
    <dbReference type="STRING" id="796604.A0A2X0M842"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY48733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="58" mass="6018" checksum="C46DA40305718D97" modified="2018-09-12" version="1">MVPKAAEKKPASTAGKAPASKAPAGKAPAKKAVKKAPAADGEKKKKKKPRKQTFSTYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MAF4</accession>
    <name>A0A2X0MAF4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g04213 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g04213</name>
        <name evidence="1" type="ORF">BQ5605_C006G04213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY57039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MAF4"/>
    <dbReference type="STRING" id="796604.A0A2X0MAF4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY57039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="583" mass="64944" checksum="3D2BDCADCC945B57" modified="2018-09-12" version="1">MKQLAKLSGARLQQAKTAVRILIDLWHFFDRIYVSKKHGAAKAFAHAFSDAVFIPNADDRLLMEARLAKLGMTWEEAVRSPVWNKKFWRRLKQPLFNKAAHEAAKRCPEAIRKGQVSDPVGIKLYTDLGPCGGPDGKADDGVRLYSCQRGTNSLEGGIHRNLCQRFPKSGVSPCHANACLADYVLVHNLMVSPTSPSRFEEAATFLTHYPLYSQVGTFNRTGKPFVGHYDLWLTVELHCLRRKTSAFLPRHSTTVSDIVNPLLYTPSTETFGIVPVQSPTAQMRFLIEPYHVERGTLRLEPVKWSPRNLLQNNTSAIQHMQSRLLTDRKLRHDWLAERQGTRFAVLHVHTPSERALYRYLSSKIRLGAPQNLRILEITELWNKYANGVDIFYNMPEHINTWASRWSSLANAQATMNMGGNGVRVIQALLTDPSRGRDVSMLVAKPLLGHKPPVLGRLTEIEVDAPDPPTSSIRPFVATASSDAGSSADLGTSSALTRAGTTKGARHCRFCGQTTCRLKGSKLSDDGSVTGCEGACLDCGKPFGLTDEMDPNDSQSQRFCRGLTRAEMNSRAWHQKKCHNFVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MAN0</accession>
    <name>A0A2X0MAN0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C005g03445 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C005g03445</name>
        <name evidence="1" type="ORF">BQ5605_C005G03445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY75751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MAN0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY75751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="103" mass="11411" checksum="AB87E943BD5D6A29" modified="2018-09-12" version="1">MQPNTHTFYDLNDAERAVLSEADVAQIAVYSKQGITFSGIPEANLVNLPAGHQGKASLARDREPVRQNHFFEAALGIIAKHREHLPPERQQPEQLIVRLASSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MAP3</accession>
    <name>A0A2X0MAP3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C007g04666 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C007g04666</name>
        <name evidence="5" type="ORF">BQ5605_C007G04666</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY62217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MAP3"/>
    <dbReference type="STRING" id="796604.A0A2X0MAP3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="133"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="245"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="61"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="205"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="327"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="356"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY62217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="387" mass="42212" checksum="9AE534702C48D527" modified="2018-09-12" version="1">MFTARISSVARVALRASSTAPRTLSLKKNALLIPAVQSRYTNSIRLFNSSSLRLNDKLEATTAPTSAEEEIKADHSSVDPLASTESSDATPSSSSGEVYIDPMQAQADATANDGAAAADAPAQTPDPVEVASRTVFAGGLSWNVDVDWLRDEVATAIGSTEGIVSCRVARDPTGRSKGFGFIELTTVEYAQKLVEVSPVIDERETRFEISDPSTKKERPARERRSSDQNQSSSSSFGQQENPPSNSVWLGNLEWSTTEADLRETFGRFGDISRVHMPLDRVTQRSRGIAYIDYADVSQAEDAIAAAQTIEINGRYLRANYATRQAPFSRANGEGNRGGFNRRDGGESGGRSSYGSRGDRNERNDRNDRYGDRQSSYQSRRGGRDEGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MAS1</accession>
    <name>A0A2X0MAS1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C011g06655 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C011g06655</name>
        <name evidence="2" type="ORF">BQ5605_C011G06655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MAS1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY12915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="51" mass="5957" checksum="C18974F86AC3ED0D" modified="2018-09-12" version="1">MRPNPVIKAGSSSKKRRLSKVITLEDDEDEDEDEDEDEDEVVKEEDEDFNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MBM3</accession>
    <name>A0A2X0MBM3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C010g06082</name>
        <name evidence="14" type="ORF">BQ5605_C010G06082</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MBM3"/>
    <dbReference type="STRING" id="796604.A0A2X0MBM3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08217">
        <property type="entry name" value="STKc_Nek2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF98">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="34"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="495"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="319"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="540"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="647"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGY14153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="692" mass="75188" checksum="98F4FADD7EF9488E" modified="2018-09-12" version="1">MASTEPMARPPAQRRKTLVGDHPLCTSASMEEIYEAGDVIGTGSFGIIRKVTRKVDGAVLARKELNYGRMDERDLKQLTEEVNILEQLGSNDNIVRYYERFVDKPNSMLYILMEYCEGGDLAGVIHRCRKTGTYLSEDVVWAYLTQITLALYDCHTEVDTRGRRKQIILHRDIKPENVFLDKENNLKLGDFGLSKAMAQAAMTQTYVGVRGRIFLSPSCTRLTLGITQTPYYMSPELINGQPYDVKSDIWALGCLIYELCAGHPPFHEARTQPELAVMIREGKIPDLPKPYTAHLGQVVKAMLKQSPKHRPNTSQIKALDNVKLQIRALELRKATKELRLRDHQIGLREADILAREAAVLQREKNVLHREAMARQAAEQIKEGEMALAARIAAANQAAQQTNGGCDDDLLNERENQRPVGGIEPEVFKRVASRPSLVPRRPLDERRASGIAFPRVSSVSSLMSLDETPIKVTANSVTRRRLASKSMHNLASAAGYASSVNSTPSRPASSASNGSSSSMAPSPRFGQNEFLSARRSQTAVSPSRGASLSRSSHERASTLTIPTSPCPAPYSGSTIPPVPQSPKRAHIAPAATNASGRHSNPYEDDGDVPSPFLKKADPSRFPLPPPPAAATGRTSATVSGRGPGRALGAGASRASLGGKPVSMASKLLSARAQAQAGVDEVGRRLSGLTAGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MBY5</accession>
    <name>A0A2X0MBY5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C010g06192 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C010g06192</name>
        <name evidence="9" type="ORF">BQ5605_C010G06192</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MBY5"/>
    <dbReference type="STRING" id="796604.A0A2X0MBY5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF14">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="227"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="607"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="110"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY14470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="938" mass="104324" checksum="A446DC8222C77D2F" modified="2018-09-12" version="1">MASPSLQAALSELIHHALPHLNPDQAQHQQRSSQAQLDAHTRATGGSTARSTYKDWSTLADEAQLALKRSGRSSQERLQFAQLSARLHSRAVPRNKLDTLSLLLSLAGSSSIPPTASSSAAAATSSSSSTGTTSRQAPLFGYPTPLDRPASRPSSRAANHDSNSRPRATVGVGLSSSNPNLAAAGLPRAPKLSMAAVLASHRAQLAASRPTATTTPRLAPVPESLLLRDILYIIQGIDGRFIRFKTPIPSPGEAGPRRTFKRGEIVVEENSPADPEALILEQGIEFVLEGSVYSLSAPMRVLLHTLSELGWLYRKIDGVLQRSGSTTISSAEGAAVVELGMIEQSLHAALKAEMTEYYRLVAILESQLTIEDESTRTDGGAGMSIEDMEGKLTLRRLMVWTEEVKLRMRMMGTLVEEAGGENVGGALLTSLHARTSNGDPFIRDFSSRLLRTLSVPFFATLAAWIYEGELRDPFGEFFVQLNPALSGVDERTGLLTGRSTFGLNLDQDDEGVKAHQLWEGKFRFKRVMLPGFLEESFGRKIFSTGRSLNFMKYSCGDGQWVASRHQTDGQRRALEYADIIGLEQSITAAYSHTSKRLFDIFFDKFRLMDHLKALKDYLMLGKGDFVEILMENLGPSLDRPANLLYRHNLTATLETALRGSSSGPSSLTSSTANRSSSDILRRLDARMLEFTQGEIGWDVFTLEYKVDAPLDTILDPESMQGYLKMFKHLWHIKRVEYALNGVQRRLMTGARTFLKVPELSYDFHLTRIALQRMTFFIRQLQYYCHLEVIACSWQVLEEFALKKEGDLDSLIEAHRVYLRRLVTKALLIQPKSSHRTEEERYVVLEGVRNLFQMMLQYQNVADALCNYALSEASRQEPSNATLAARSADTLDGIRHRLQDYATQFDTGAKEVVRLLGKAKDLDMRFLAVRLNFNYKFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MBZ7</accession>
    <name>A0A2X0MBZ7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Queuosine 5'-phosphate N-glycosylase/hydrolase</fullName>
            <ecNumber evidence="1">3.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Queuosine-nucleotide N-glycosylase/hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C007g04744</name>
        <name evidence="2" type="ORF">BQ5605_C007G04744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>queuosine 5'-phosphate + H2O = queuine + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:75387"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17433"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:194371"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:75388"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the QNG1 protein family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="1"/>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY62855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MBZ7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019438">
        <property type="entry name" value="Q_salvage"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21314">
        <property type="entry name" value="QUEUOSINE 5'-PHOSPHATE N-GLYCOSYLASE_HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21314:SF1">
        <property type="entry name" value="QUEUOSINE SALVAGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY62855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="404" mass="44554" checksum="F24DDB74D08924E8" modified="2018-09-12" version="1">MAPSLPPSSESILDSIRSSCRALTARSDITIDDKAIDTFLHGIGAEAWSQHLQNNHHGLRLPLRFDSAHEELNLIAYVALVLSLLNFLSGYREPLHRLTQRGAFSNILSLVLSAHLSAGDSSSSSLLSAKGMRNATLTQISSMAQIQTHQEKPHPTLGPVVKVGEKDDDAFEILELIVRVLNRTGEVLKKEGKEDLGHWVQQALLEVEGESEQMLRKIYDTFPDFQDAYTVGGECECCFLLHLESSAGETLTPFCPWTPAAVCILKKALYLLNAITVRFSASGSPDHAPTFPLPTNTTRFPIFADNVIPSILMHHRIIVLPTSRTLPTPPLLSTEEATRLRAASISACHRIVERAQVLSGNGPENEWMRGMLEVDLDGYLWDSGKRDSIGKNVVRIAERGTTMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MES7</accession>
    <name>A0A2X0MES7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C005g03701 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C005g03701</name>
        <name evidence="3" type="ORF">BQ5605_C005G03701</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MES7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF463">
        <property type="entry name" value="REVERSE TRANSCRIPTASE TY1_COPIA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="112"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="592"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="690"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="690"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY77700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="717" mass="79027" checksum="BD975AC90A62EB90" modified="2018-09-12" version="1">MRLARSARLSPEPSGEWIPHTPAVGPGQPSDDDSPDEIDFLSRHHRAFIATDDDDPTLEAIEPVKSITSDSQTWREAMSSDEHDLWAQAASDEFTAMRDNFKVFTIEPRSSVPPGATIVTSKFVWKPKRNAQGDITGRKARLVAQGNRQHDGIDFSETFAPVARFSSIRCLLALAAANGYHVHQADIDKAYLHGELDHDIWMTTPRGFDFPSDQVLRLRRSIYGLKQASRIWNRHIDTSLRSLGYKATGTDHCIYSRIDDQKQPHYIALYVDDLLIVSPALDEIERVISGLEQRYGVKRLGPAEYMLGIQIRRLEDGSIALSQECYIMDVLARFHFDTTTRGATVPMTPGLSLTAVPGQGTEHIRSWYLQAIGSLLYISLGTRPDIAFAVSYLSRFANNPGRRHWVAVKHVLRYLRAMYRDELLYACGPAKITGVVGYSDANWGACVDTSISTMGFVFYLAGSAVSWSSKRQTRVADSTTDAEYLALSHAGKEAIYLTQLLSELHVRPVDAAHIFTDNEAAAAVAHDPVHTSGTRHIRLREHFVCDMVHRGDISLSHVGTANMVADIFTKALGPKIFGVHCYALGLRTRHPRLKSTSRSRGGGPGASAQGLGARSEPGALAQDLGAQSEPGKLGARGSHTVFESSQTTFFKREFGRSHNATKMRTLRRWTGPMHNDSFLPHVSVAEQPVPPVHSTAPPPQGLAFNNPGPAWSAPLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MEX4</accession>
    <name>A0A2X0MEX4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C039g11808 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C039g11808</name>
        <name evidence="3" type="ORF">BQ5605_C039G11808</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000060">
        <property type="protein sequence ID" value="SGY90453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MEX4"/>
    <dbReference type="STRING" id="796604.A0A2X0MEX4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="134"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="234"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="260"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY90453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="275" mass="29975" checksum="76C3B4C41247C6DC" modified="2018-09-12" version="1">MQPGLYLWAIQKQILLGDAATGKSSLLVRLTDDRFLNHSEPTIGVEFGSRLVELTEGEDKGKKVKLQIWDTAGQVRSYYRGAGGALLCFDLTSRSTFLSCQSWLTDLKQWGEEDLLVLVVGNKKDLIRSPRRRRRSSRDEVVEEEEEVEEGRSGSEEGSLMVVGEGIEGEVEEEDGERRIVPGGGGDDVGGVEELRKEVQAWVEEQGLAGYVETSAKDGEGVQEAFNELTRKVHEKHQKALSAQRARGGSNGSKGFRLTRGGGASTTNEGGGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MFA5</accession>
    <name>A0A2X0MFA5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">BQ5605_C037g11573 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BQ5605_C037g11573</name>
        <name evidence="16" type="ORF">BQ5605_C037G11573</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the XPO2/CSE1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000062">
        <property type="protein sequence ID" value="SGY93106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MFA5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005043">
        <property type="entry name" value="XPO2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF8">
        <property type="entry name" value="EXPORTIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03378">
        <property type="entry name" value="CAS_CSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="15">
        <location>
            <begin position="15"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Importin N-terminal" evidence="14">
        <location>
            <begin position="589"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="56"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SGY93106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1555" mass="172174" checksum="00EB97B58886BCB7" modified="2018-09-12" version="1">MLIAYPASTPPHLEPEEVSLALSDIATAMAQARNTIVMLGAGASTKAGIADFRSKGTGWYSRQTPRSTSEAAHAPFSDEASSSPSSSQASTSSQARTSSQDDPTPTQLRSFFSSSSFRNPSTRVQSLKFFASFKNQVDQSLASSLSSRGVTSLHRFLGELKVMRKLGRVYSQNIDGFERSGGLSNVELGAGAGVGKERGDTVQLHGTVQDARCSECDHEEWCGAWVVQEWASGEKVDCPKCKRTIWSRSYLRPSIFLYDELIPHSETIVRLANHDILQIDCLLVCGSSLRIDGFVKMERSFAGAVRARGGMCVLVNRERVASSWEEVIIMSWRTVMTLWTGSGRSGELRIRTWIGIKKRQRAFIRSVMPMTSTVTKREQNITTQSVADVEHQGPIPSAQTRNCSEPQLVLGERSCEISTRPTKKTRRTTASRKVSAGDEIRDDIDTREAREIVLMAETILKKQARRKRAEESSASGGGRRVGRSSGGYEIGLVICRLGVCTLLGLPFHSTFNCEGAPRRSALLLLTSSCTYDALSPDVPPPPTHPIGGVLTLELLDLPRNTSSDMAELEQLAQMLTSTLDSSAATRRQAERNLLQIQAHPSFGVWILQLAQDGNRNKTIRQSAALNFKNWIKANWALEEAPTPLTSSTAEGLKQSIVAIMISLANAPALQVQIGEAIAIMAEADFPDRWENLIDQLVQSLTPNDFVVNIAVLRTAHSIFRRWRSEFRTDRLFLEIKFVLDRFCAPYQQLFQQTDALLSSPTLTADQHALLLKTILLLLQIYHDLNSQDLPEFFEDRLGDFMTLLLRYLDYSPPAALQTPDTDDDDEEAAGDMENIKAEVCEIAQLYSLRYLDAFGEGGYLGPFVQKTWELLTKLGLAVKYDGLVSKATGFLGVVAKMPSQRALFDGEGTFPSICEKILLPNMTLRTFEEEMFEDDAPEYVRRDLESAKLRFLGSETRRQAASDFTKALMEQFESQVTKLLLQYVGAYLSQYEANPATNWKSKDTAIFLLTSIASRGSTAQHGVTSTNALVDVVDWFSKHVLGDLQAAPGSIHPIILSDAIKFLYTFRNQLTKEQLLAVLPLLVPHIEHPSFVIHTYASITIERILFIKQNGAFLCGQADIRPYSENILNALFKVILRGETPQLIAANDHLMKSVMRVIITSRQALTPIYVTVLRNLTGILGEISKNPSNPKFNHFTFESISALARFVTSGTPSTLPEFESALFPLFQVILQNDISEFTPFVFQILSQLLELHAEGDFPEAYRVLLPPMLTPALWESKGNVPALVRLLRAFLARGAPSIVEANQLPPMLGIFQHLVGSKANDAYGFELLESIVEYVPLNSIRQYMSNPVFMLLLTRLQTSKTDKFSQGLLRFICFMAAINKPGLDVDGVVRMLDGVQPQPGLFGQVLLVLLPEVQKAPEQNRKVIAVGLANILTHSLIMVEEPHVRAWSPTLEALLKLFLLPATLSKNVSADVDEIEVADLEETGYQASFSKLGASERVRPDPVAHVVDPQAHLARQLSELSQAKPGQIRPLVEAVDPEFAQPFLAYLSSNGFGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MFH3</accession>
    <name>A0A2X0MFH3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C014g07527 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C014g07527</name>
        <name evidence="2" type="ORF">BQ5605_C014G07527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY18985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MFH3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015872428" evidence="1">
        <location>
            <begin position="20"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY18985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="137" mass="15279" checksum="CBE914A1AC38BE53" modified="2018-09-12" version="1">MYFQSTFIVLCSLASVAFAVMSQGNLNFTRDYIVVYSPTLFNRTEDFCRAFRVVCVEIAGPKNEHHQLDCVFPQKGPRIHAFCGGIAKNPTGGWIRGQPVFDHTPEAVKKIHAMIEGQPMGKTACLKFKKKHSAVVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MFR7</accession>
    <name>A0A2X0MFR7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C008g05172 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C008g05172</name>
        <name evidence="8" type="ORF">BQ5605_C008G05172</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MFR7"/>
    <dbReference type="STRING" id="796604.A0A2X0MFR7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF1">
        <property type="entry name" value="XAA-PRO DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="7">
        <location>
            <begin position="4"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY79591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="491" mass="53864" checksum="21C3DA0E3C4CF1B9" modified="2018-09-12" version="1">MPTASSAAFPLNHAHLLLRRLLKLNPQASSVPALHYIYLAGETVQSRHDTDRELPFRQESNFAWLSGACDVPGSALTIKYEHQGGGIELDEDKVETKLHLPAINPDEVMWCGLPPSPADLSTSLHFTSIEQGWTPISLFPPQSPLKTFIHHLPWTRPPTSLVSRINGPTATSEFLIKALHEARRNKTPQEIEWMRKASEITAGAHLALMKGIGSGEIKDENHAEAVFVGYCRKQGAVHQAYTPIMGSGERAGTLHYVANAQPFPDTQPGALILVDAGAEYNCYAADVTRCIPIGNGGRFTKECKEIYELVLEMQMAAFEMVKPGASYEDIQLKMHEVAAKGLLRLGLFKPSSSSSSPSETETIQSILESGLTTAFYPHGVGHLLGLDVHDAGGLPQGKSKHSLMKYLRLRVPLEEGFVVTIEPGVYFNAFLQKDWKNSPFVDWDKVEQYAYVGGVRIEDNLLVTKSGFENLTPSSLPKTVAEIEAVTTSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHB1</accession>
    <name>A0A2X0MHB1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="22">BQ5605_C032g11022 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">BQ5605_C032g11022</name>
        <name evidence="22" type="ORF">BQ5605_C032G11022</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000067">
        <property type="protein sequence ID" value="SGZ03814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0229">DNA integration</keyword>
    <keyword evidence="15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="12" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="16" id="KW-0862">Zinc</keyword>
    <keyword evidence="16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="20">
        <location>
            <begin position="422"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="21">
        <location>
            <begin position="1542"/>
            <end position="1714"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="19">
        <location>
            <begin position="1857"/>
            <end position="1918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="483"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1292"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="42"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="484"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="512"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1299"/>
            <end position="1313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="SGZ03814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1920" mass="213269" checksum="EEE2EF76B6368CCB" modified="2018-09-12" version="1">MAEPTDTSRDTTAPVREDPSRANPPKSPPTHSPHPLQAAAVITSLESRLAESEALRRDSETRIRKLEQMVERLMRESTAPAGAQVGEALPVRPVPLDVPPHTFLGRPGAAADPLARTPGGESHSGIRDGPSSAVISSRWRGTLPDREGLWTGDHPERLVIFTAFGESYLSLLCDISTSDLFDTSRVIQLVATLFSRTTTRQRRQSPLDWAVEAMRDALGEGRPHCWTSLMKAVGRRWPDPGFADRVAQDFHGCRQSSSRAYDHVGEWRARYRAFVHDNDSFTLSPLQLATTFYQSLSDSSKREVRAGMLREYHDNSLVTIGRFGLKVPSIDEITEWAAIADDISPPPSVPTPPSRTATYGAIVKAPRVSPPATNTPTVDERFQIRRARWVDRATKWQQSHLWKDRSTWFSPAPSGVPTSMACFNCGRGGHFSQHCTAERQSPVAVQLSAVAVADLDDEDWSSVAGGDEDPEVRVPISLERVQTRPLSSVSASMTRPSCPPADPVGRMKEGASSSVDVEVSSSNPQPTAPASDADLRRLADDSTDSAFDAVEDVPSYADAASRMRRYWGPEVVSSRKAERTASVSSVRVPVPLGVSLLESDTPLIDVDDFARPAEPAIVRARNIIAWTLPSGRTLRCLVDSGSEVDLVDQDVVRTDPSFTTSRLTAPLHLRLGTRDKSDRCAVFANALFTSGSLDLGLRAFFICRVTAYDAILGLPFLKDTGMLVGWGVFTVARPGPSQPVAKGTHEWDRAVTVAPICSGSAIGYDHPGLLPDDEIIGLEPHNPLLDVVDDPALEDLSESEARTRLAALLEKYSDVFVDSLPMDRLPPYRPVNHEIPLIDPNEKVKPRVYPLADKYRSQWAEHSAKYTRGRFWVSGPIDSAAPVFAIPKKNSQTARFVIDLRARNSNTAKRFSPIPDMTSVRYEVARSRYRSKFDVAAAFEQVRVIPEHVDRTGFATVTGTYTSRVMQFGDTNAPNTLNLLTSAMFQPCLSFAKIFFDDVHVHSDTRRAHLRHIEILLMTLRHYRFYLGSNKSEWFSKSLDSLGAIISDDGIEVDPAKWERIRQWPTPHNKTDVQRFLGTVNWMRDHLPHLSITLEPITALLAQSTSWRWNEHEQQAFDTVKSLVPATLRPIDGAKVTSGEHKIYLFTDASRVGIGACLASGPTRSQAVPTRFFSAKFNGAQLNYHVTDKEFLAVVSACRAFEQHLIGYPFVIVTDHQALRTIKTQKLRQTPRHIRMCLELSRFDFEFEFIAGKNNSLADSLSRLWEVKEGSPEDQVKENELEDMFFDGERHGFTTHGESLPEERPYTSPSHDRLPPVDCAFGPWDHGYDAGSPGSHRLAENIMDTVDSSTGPLSPPIAVNRVQAIAAAPANDAPIPVDADADELDLLGAAADEVNDAPVVHRPPDPLPQPFLDAVIRAYAHDSQAQVIVDDPLSWPMFRVTEEGRILRVHPDESLSLFVPRGLATGVVDSDKVPSLRELVLAEIHRSVGHAGHRITLAAIRPLYWWSSMSADCAKFCHSCEDCARGKASTQVPYGRLHPMPIPSGPWEQVAIDFMTGLPPVEFEGMMVAQIMVVTDTWGKMVRLIPLPADADSELVADRYYATIFRLHGTPSAIVSDRDPKFTSQFWRALQAKVGTVLRMSTAAHPETDGSSENRIKMVTQTLRIMVSSNHEAWASRLVEAEFALNSSVAVSTSLSAFEATYGYLPRRWPTDSWSVSDVPRAEAFARIRQLRNLDVTDAIIGARLDQTHQANKHRRPDDPAFRTGSYVYLSTKNLAVPEGMKSKLLPRYIGPFRIRAAIPATSSYDLELPPAMSRVHSRFHARLLRPYVENDAERFPGRDPAVLFVEDVADAADNSAIPERIVRDRRNARGNRSFLVRWIGRKDIDDTWMSEQSLRFDHPSLLDTYLAQLDRSNRRLSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHE0</accession>
    <name>A0A2X0MHE0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BQ5605_C016g08237 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C016g08237</name>
        <name evidence="12" type="ORF">BQ5605_C016G08237</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY21437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHE0"/>
    <dbReference type="STRING" id="796604.A0A2X0MHE0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF21">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="407"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="886"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="915"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="956"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1015"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1054"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1087"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="11">
        <location>
            <begin position="126"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY21437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1122" mass="122258" checksum="2B2EC9AD0375B3E7" modified="2018-09-12" version="1">MVKPILSLSKMDSLEPKGSGSDSDSGELKDGEKGGNPRRYMANTPISPTLSFRTTPRFAFDAPIHHETHHRHPFSRANSIAGQAPTLQLPVEFRTMTINVTETQTHPENKSESKNKDPAMRLADVEWHKLSSEEVCERLGVIPAVGLDLEMAQRRLAKDGKNVISPPPQNLPKKIFFFVFGGFGTLLFGAAVVCIIAWKPLGNPHPDPSNLALAIVLLIVIALQTFFNAWQDHSTGRAMASISGMLPSDVLVCRDGNTFKIAAADLVSGDIVKITLGSKVPADLRLIECSSDLRFDRSILTGESNPISATTHNTDPNFMESHNIALQGTLCLSGSGLGVCVALGDNTVFGRIAKAATGARPVKTSLEVEISRFVLIIGSLACVVALSIVIFWFAFLRRYYPSFISVSALLINCVSVAVAFVPEGLPVCVTVSLTVIAGSMKKKNIMCKTLSTVESLGSVDVICSDKTGTLTQNRMTVTEVVIGDSVIHVKEAQRMVMNKAEHPEGAAVEVLASIAGLCNDAAFESDDIGLPTHERKINGDATDTGLFRFAEDAVDSCTKLREFWVCVGKLAFNSKNKFAIKVFQPLTALEVDIVVAPAIAADAYRPEDYLMLVKGAPDVLMKRCSTYLTPDGNVLPLDEAAMAFISERQIELAGQGKRVLMLTKKLIRANIVKDNIDDEDALMDFNFDLTIVGLAALVDPLKDDTAETVRVCRGAGIRFMMVTGDMSVTAVSIARSAGIITTNKVHGLEDLQRDLLEGMIEPYDIDTVANRPLRAIALSGAELLTMTASQWAQVATFDEVVFARTSPQQKLQIVKTYQESGSTVALFGDGVNDAPALKQADVGVAVAGGSEVAMEAADLILLDDFSAIVVGIESGRLCFENLRKSILYLLPAGSFSELMPVLLNVFFGLPQVLSNIQMILICAVTDVLPALSLCYEKPEADLLSRKPRNRKKERLADAKLICHAYFFLGIIESLTSLVGAFYFGFQRKGVPFSSLWLNYSDAPIDPKMLAHAQSIYFFNLVIIQWFNLLSTRTRRLSIFSQPPWGSERTRNYRLFPAMVAALLLAVFFSTVPLLQRVLKTATPGIEYYGLPLGYGVAMLTLDEVRKAINRRYPKGLMARVAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MI17</accession>
    <name>A0A2X0MI17_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C039g11807 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C039g11807</name>
        <name evidence="2" type="ORF">BQ5605_C039G11807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000060">
        <property type="protein sequence ID" value="SGY90446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MI17"/>
    <dbReference type="STRING" id="796604.A0A2X0MI17"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY90446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="203" mass="20971" checksum="C590FF03479FED4E" modified="2018-09-12" version="1">MGQDDQPSSVVPLARTTMQAGQVVVEVERAAPVEAGVLVVSASARPLTVSPSEPISLITSAVATAPTAAIPEDNPVAEGVVQDSTMQGIDSSDVSPQSTQSHVSPAATNTPVAVPAPASVPACAAPRAAPPPPPPLPRDDQVQHNGLPPPPPLVTQPLQPKPKPKKPRGRRKKELDRGRVSFRYRAAGGSHRIILVDPLPSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIV3</accession>
    <name>A0A2X0MIV3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C018g08802 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C018g08802</name>
        <name evidence="3" type="ORF">BQ5605_C018G08802</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY26821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIV3"/>
    <dbReference type="STRING" id="796604.A0A2X0MIV3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="297"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="322"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY26821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="503" mass="54426" checksum="614D23955E6D1CF5" modified="2018-09-12" version="1">MVANIFTKALGPKVFLTHCYALGLCTRHPHLGSASHSLVIVLYPDPSISVQIATLQAQLTALQASQPPAAAAAATPPVTAMQANTATVSKVVFPKHARLDGPKSFTNWLRQLRLALPNQARGYLLDGVIPPTWTADQLAARDNAAREIIVGSIDSADVSATLDTIPSNDLSAPRIFAALKARFAPDDATRTLELFARLWDFRKMPASVEAYNMWLREYMSIAQEIRDAKTSLNDVLATHVLAMVPSCLDSFRLTFTDEQRNRRDLPELTMLTDCIRIQLHSAGLSSSHSAMLAIASPCPACRAPGHRLRDCTSRAKHPPAGPCRHCHKKGHWALDCKHWGEQKHTGDDNQDDISLPAAQQPNVAYFASCLFARRQLPADAFVVDSGGTAHMVADRSLFTAYRQTAHTKIGGIAGGITAIGMGDVAFVAKTGHLITLRGVLPTPGLHVNLLSVSRLCDTDCDGQAIAHGTRVNEGLYLLDADHTKCQQLAFLSHSESTVPLLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIY3</accession>
    <name>A0A2X0MIY3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C131g13374 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C131g13374</name>
        <name evidence="3" type="ORF">BQ5605_C131G13374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000059">
        <property type="protein sequence ID" value="SGY89327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIY3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010286">
        <property type="entry name" value="METTL16/RlmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393:SF0">
        <property type="entry name" value="RNA N6-ADENOSINE-METHYLTRANSFERASE METTL16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05971">
        <property type="entry name" value="Methyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY89327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="168" mass="18696" checksum="B6DDFFA1958AE4B2" modified="2018-09-12" version="1">MPHVHNPYADGPPDYSQLAQDVPYFAPFLRTNPYGGSTIDYKDENALRYALVPPTQPFSARPVHPTYPHADAPRRALSSALLERDFGLRIELPRDRLCPIVPGRVEYVTFILRLVHLNPQRSSHVRGLDVGTGASAIYALLVAKMQADAFVYGSEVDEHSQSCAIRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJ32</accession>
    <name>A0A2X0MJ32_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C083g12992 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C083g12992</name>
        <name evidence="5" type="ORF">BQ5605_C083G12992</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000034">
        <property type="protein sequence ID" value="SGY28204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="506"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="267"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="755"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1439"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="762"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="783"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY28204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1854" mass="202083" checksum="72E89AB36D706668" modified="2018-09-12" version="1">MSDSDVPKPTTLTVPPPRPPTQITAFAASDLLRDADGYQDWVLTLCSRMPSDVIDYLKSGVPPTSWPPAYVPLWDHYARASICAAVDPRLVLPGLSQYFGDTHSGHKIWAALRTRYGAVSAVDLLPVISRLFSPDLMPDTADAFLQFRDRFENDSRLLNDSDVTTDSLLASHLLARMPPSLSAWRTTFVNSQGTSRTLPHAAEILDRIYREIKARPIDPLAAATVTATSPQRTPPSPCPNPTCRKMHWLRDCPDTTWAAAFRARKAASGTTSRAHKKGSRTIASPAVTSPTDTERPEPTTFTACLLATPSAFPKSAWLLDSGANRHMANDSTLFSSLRPFTGPHVAGVAGSLPSTGCGSVRLSTSAGPVVATDVLLVPSLPCNLLSVRRLDRLGFTVSFGSGHAAIRNSSGTVVATARAIANDLYALNVAPSTCMPNALLATPHRVSLLTLHRRLAHLPVAQLKNVVQKGLVTGVDWVYSEEEFRSFHCNACLASKAHALPFARSKSIAPGRLALIHVDVAQMPRASFGGHRYMLVIVDDYSRKQWCLLLTYKSDVFHRLRDWILEVENATGDRVKTIRSDNGGEFTLRTFVDFCVAKGIRRELTIPYTLNKTDVLNAPTAPSKRAAKYFVHCKNLLPHAGIHGEVPDTRWYGMAPDVSSLRTFGCRAWHCLPSVKRTDLDPKAVPLIFVGLDDHAKAYRLFDPATRKILLSRNVVFRESEFPALQPAANTTTGATPLPVAAEVYPDQVDHSEPLLVASPRSPAPRAAPPAAPPGPAPVASDQGPSPASDQGSPTASDQGSSDSAISTPCPSLDQCDLASFCLAPEFPDDLDDALHSPPPVAYLASGAAALLNNAPPDSTELIAPARDPPHWRAAMATPQADEWRLAAQAEFDSLSRDFSAFTPIDESLVPADAKILGSRFVFRTKRDQHGQVKSYKGRLVARGDSQRSGIDFDETFAPVAKFTSIRALLALAAAHGYHVHQADIDKAYLHGKLDKPLYIRVPDGIYMPGKVLQLHRSLYGLRQAGRIWNDEIDSALSALGYAATESDHCVYVRTAGDERHYIALYVDDLLMISPSLPEIERTLQGLEQRYGVKRLGEAEYILGIQIRRSDDGSITLSQEQYLKDVLARFGMSDAHPVATPMQPDLRLEVELQPTPFPDRTRYLQAIGSLMYASTGTRPDLAYTVGYLARFSRAPSTAAWGAIKHAFRYVAGTLSHGLRFAHGASPPLVGYSDCNWGACLSSSKSTMGYNFIYAGAAVSWSSRLQSRVADSTCDAEYLGLSHAGKEAIFLRQLFGELGLSSSEPVLIYGDNQGANALTKNPVFHARTRHIRLREHFVRDMVSLGDIVIQYITTSEMTADIFTKALSRDLFARHRGRLGAGQLAPRFSLSCSSNFIGLVSLFPALRPATDVRAEPIPLPVTVDAYPDQVDPLEPSLVASPRSLAPRAEPPRPVPAAPDQGPHRPAPAREVPDQDSLAPPAPDQGSPARAGFPDDVDDALHSPSAVAYLASGAAALIETSPVDPAELIAPARDPPHWRAAMATPQADEWRLAARDEFDSLLRDFSAFTPIDESLVPADAKVLGSRFVFRTKRDQHGQVKSYKGRLVARGDSQRSGIDFDETFAPVAKFTSIRALLALAAAHGYHVHQADIDKAYLHGKLDAPLYICVPDGIYMPGKVLQLHRSLYGLRQAGRIWNDEIDSALSALGYVATGSDHCVYVRTTGDVHHYIALYVDDLLMISPSLPEIERTLQGLEQRYGVKRLGEAEYVLGIQIRRSPDGSISLSQEQYLKDVLARFGMSDAHPVATPMPPDLRLEVELQPTPFPDRTRYLQAIGSLMYASTGTRPDLAYTPVKHAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJL2</accession>
    <name>A0A2X0MJL2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C033g11166 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C033g11166</name>
        <name evidence="4" type="ORF">BQ5605_C033G11166</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000066">
        <property type="protein sequence ID" value="SGZ01816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJL2"/>
    <dbReference type="STRING" id="796604.A0A2X0MJL2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051412">
        <property type="entry name" value="Formin_Homology_Diaphanous_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691">
        <property type="entry name" value="PROTEIN DIAPHANOUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691:SF6">
        <property type="entry name" value="PROTEIN DIAPHANOUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016050141" evidence="3">
        <location>
            <begin position="27"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ01816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="518" mass="54416" checksum="FB15E94B71B97348" modified="2018-09-12" version="1">MLLQKRVSVGALLLQLSGSIIQLVASDAVLPTCGISCVQLNTTCLLASHHCMCVNATLTLPACVQRSCSSSDQATSWNNLDAFCSERFGTPYAVYLGGGSGTPSPPILPPPPPPPPPPPPPPPPPPPPPPPPPPPSNLPNATHNTTTNIGTNNPLKNGTTNNNGTQTSSGTTKNGTGTYQPVIPPPNTSKPSPPPNSQTKAPTNTSAGSTSTGGKSSHAGKSNSSTGGASINSTKKHSHVGAIVGVTCGGLVILLLAGGLFFKRRAQRLKARKNAVGIDWDGHQPDAGMNVTARTFFAATTPADHSLSYYDSQPPMVQMPSDTWEQRREWPANDPDSGWERRAEFSGPTVAEHLEATVANDAAAGYNRPFAPMEPGGSQQDCWSSARPFGDYRPMRPMTLSLGERGRLETAGAHVSKSDLPPVSGLVTGKTWPPSDSSYSTSVGEHGELGDQSPHRPNPSQWFGSSNDYLSQPVMGGRRPTSWAPPLESDGESDNRDPSPGHQKLRMVVANPDAETRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJM1</accession>
    <name>A0A2X0MJM1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C002g01095 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C002g01095</name>
        <name evidence="1" type="ORF">BQ5605_C002G01095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY29913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJM1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY29913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="34" mass="3891" checksum="10E9D0D071B0FF1C" modified="2018-09-12" version="1">MRCWTLDGSFDEGKGVWKMQDASVLFEGFKSTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJR3</accession>
    <name>A0A2X0MJR3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C033g11216 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C033g11216</name>
        <name evidence="2" type="ORF">BQ5605_C033G11216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000066">
        <property type="protein sequence ID" value="SGZ02554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJR3"/>
    <dbReference type="STRING" id="796604.A0A2X0MJR3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ02554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="150" mass="16642" checksum="2B1AE9D55E9F7429" modified="2018-09-12" version="1">MATPSTSSVPLAPPSLPLPTEFEQLLLSQSQLQYNLASLQQLATRLSELSQARKEGNERMDIAVDLGMGYTIQGVVPNTDKIIVASGVQDLWVQLRVDEAEKFVAKRHEILQKRSESLNKEVDKLRQEYALVAETLRRALAPPSTEVDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJY3</accession>
    <name>A0A2X0MJY3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C010g06164 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C010g06164</name>
        <name evidence="3" type="ORF">BQ5605_C010G06164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJY3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015995707" evidence="2">
        <location>
            <begin position="21"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY14382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="159" mass="17800" checksum="74F312C49EEAB8A5" modified="2018-09-12" version="1">MLFKLPVVLAMALLTLGASASERFTVTSLRRRDQPGDYPQDRGSVKSPTKGQQLKVNERFAFLFNPISVGDLVDTLDVEVFLKIKSLNYSRRLVTNLMSPGDNKPIVQNFIFMHPKGSHVKAGTILPGTIEVFEQQNGTKSYGNSNYFLNQAVDVKFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MK30</accession>
    <name>A0A2X0MK30_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01235 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01235</name>
        <name evidence="2" type="ORF">BQ5605_C002G01235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY31499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MK30"/>
    <dbReference type="STRING" id="796604.A0A2X0MK30"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="593"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="640"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY31499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="696" mass="74381" checksum="5861EBCAD15558A7" modified="2018-09-12" version="1">MEAVSPPLYSSTAASVAPPAVLLNVAPLPTHNDFLLGHLGYGQASLQGEVQVKYTSEHGHGQAPRPSKLEVCFRGVERRYGLGEIELCEQRKTLWGWGAQGSSSSMEQGDDVPPPSTVFKFDVTQDLPHCIHLAQSSLEYTLTATLHSDDASVAPLVQCVPIHLARTSPPGPLSSELVSSAPAPASADGSRPSLSPHSVSRQDPIHFTVHFSRTVFRRSEPIQLVVKIPVPDFDAVTKGLRLRTVSAELVRRISLANDTDDDPPAVSGKQRDQAVSTAVKNGDIDSLEFIQHPSSSDALSDPSYESTMVLARSGKSARFSPTRPIVIRLLLHPSTMQFCESITQSTILHHMSFCVIVTVGLLNNRSQRDVTVSRDVHIVPDPPMTSTTLSEKQRQVEAEVESVPPGWTPTEGSIPSYHESAVGDLAVGTSSDFREGPSRVGSTHVFPTDLIGEEEYDGYEELSASLSTRAPPPTIDADVSPPSHDEDDSDSMQSTEEASPGFDATPLAPPDDFAGEFFRPVDPALQALRRPLDSDEEEEDPALMYASANSEDVVFLDLSGSAPPSNGTSTHSSAANSPVFRAVQDVSEQINAATLDDASPPPYVGDTSQNRSDLHARPPSFGTEVAVARGHSRSTGILEVTDGGGGGGVHRDAPGASASPSLRPPPPSYTSHQDVVLRLTEQGDLVRMVRDVEGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKK6</accession>
    <name>A0A2X0MKK6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C022g09414 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C022g09414</name>
        <name evidence="2" type="ORF">BQ5605_C022G09414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MKK6"/>
    <dbReference type="STRING" id="796604.A0A2X0MKK6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ22019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="288" mass="33217" checksum="4991972186425793" modified="2018-09-12" version="1">MYRVGTKKKKEPALRHEHVWARVGQKLKAKALLPKTAVRPARIPLKEDPHPRCFNFFGLTRPFTIRKLRRLVNTVRFPGKDGQDRALPGGQPQEPRVKRFPEGTSQSGRQRFWSWLHDRFASAAEQDTHWRLMYDVTPTRKKQHVQGHASSPSCLFCGNDAAVIETVSHYFFGCAYSASYWSGVLRILFDKLGIEDTDVDPSTFTQEQLTMGLPLLRGRGRTTSKWMWVRLACAIGFQRLHLLRWHVHQRFEKDRVVAPPSIPSALRAFNRDYLSRAGFVPGARDWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKY1</accession>
    <name>A0A2X0MKY1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C022g09544 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C022g09544</name>
        <name evidence="2" type="ORF">BQ5605_C022G09544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MKY1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ22801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="660" mass="72447" checksum="E359CAB32C4E4361" modified="2018-09-12" version="1">MTADDKVSEAPRDVRARDQGRSRQIKASLRRLTATGQEVAEFGQRRSPGEYVLSEESLTSVYHDSSIVDRALAGLCQLQGLIKSGMLHTPLPKTTQMDLEAQPVFNFSKFDSPKTASYALTCIKQSIAKYTIEDLEQDDLQVRWSESSLTTTDLGPDSELQSLQSLSIVRWYDAELQNEIKTNEILTTVAFHGRMAHNLEACYFDSPSSSNGDRTSAGLGSELLDIRLVASTGRLHDLRGGRTIAAKLALHIRLAKRARFGVIFAPPYFVLVESVVVDRQSHLLVGDLHSIVFDPDEPRATVKPFNAIFLALLMNHHVDYRIASPPQHVLNNVVRYSRSLDSAPEADNASALDRPPIVSSNSSDDPFRFSPGACHASLPGDDDSVKNAESKNARSEPDGPSKLFTCNGVTATLHLAPGQTIICDAKIIPDSRMAASPIELRLEYETASSSLSETLRAKKKIRLDAEASRRSNLVSEALSPELQQLFKRASTFVLHKREFKVKFAPPSGSRLDLAQWVQKGVASGRPHVTRRSSCVGVGQGKLVAKIVSEDFAPSIAKEYYVYTSIVPLLSLKARQYFPAFYGLYQSGTEGHAYVLVMEDAGSTISPEQLQLNSELKAKVDAALKLIADEGLVHGDEGARNVLLRPDGRICLFDWGEALLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MMI9</accession>
    <name>A0A2X0MMI9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DNA 5'-3' helicase</fullName>
            <ecNumber evidence="17">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">BQ5605_C015g07784</name>
        <name evidence="21" type="ORF">BQ5605_C015G07784</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. RAD3/XPD subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="17"/>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MMI9"/>
    <dbReference type="STRING" id="796604.A0A2X0MMI9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045951">
        <property type="term" value="P:positive regulation of mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000135">
        <property type="entry name" value="DNA repair helicase RAD3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000128">
        <property type="entry name" value="Putative DNA repair helicase RAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010643">
        <property type="entry name" value="HBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001945">
        <property type="entry name" value="RAD3/XPD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06777">
        <property type="entry name" value="HBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00852">
        <property type="entry name" value="XRODRMPGMNTD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="20">
        <location>
            <begin position="7"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="781"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="793"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="SGY17434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="821" mass="93260" checksum="3137E0197D927BAA" modified="2018-09-12" version="1">MRFFMDDMEFIFPYDKMYPEQYAYVHDLKRSLDAEGHCVLEMPSGTGKTVSLLSLIIAYQYHERKMGRPERKLIYCSRTVPEIEKALAELKRLMKYRKEAYGIDDVDFLGIGLSSRKNLCIHPSVKSEKKGKAVDARCRDMTNGAAKARWEKDPESVELCDFHEKLGEMDQDRLIPFGVHTLDDVKAYGIKYGICPYFAIRRMFVHASVIIYSFHYLLDPKVAEQVSKEMSKDSIIVFDEAHNIVHLGLSFLDNVCIESLSIDLTRPILDNAARCVESLDVKIKEMKETDKEKLEEEYAKLVEGLRGNLGEDEEANGEADDFMANPSRCLPFALALRSRRLIRSLPVLPADILQEAVPGNIRRAEHFTAFLARFVEYLKTRTRVLHVVAETPVSFLQHLKDITFIEKKPLKFCAERLSSLVRTLELTRIDEFSPLQKVAAFATLVATYDKGFRLILEPFETENATVPNPVLHLVCLDASLAIAPVFERFSSVVITSGTLSPLDMYPKMLGFEAAVLESYVMTLSRDCFLPLVVTRGADQTEISSRFEVRNDPAVVRNFGTLLVEMAKAVPDGVVAFFPSYLYMESIVSAWMEMGVLNEVLKHKLIFIETPDAPETSAALDNFRRACDNGRGAVLLSVARGKVSEGIDFDHNYGRAVIMFGIPYQYTESRILKARLEYLRDAYRIRENDFLTFDAMRHAAQCVGRVLRGKSDYGLMVFADKRFAKLDKRAKLPKWIGQYIKDSDTNLSTDLAIAHSKKFLRAMAQPFVESSKSAWGIDQIMEKQAGLDPNRDPDNDEPEEEDDEADEYGDMIDDEALMELDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MML9</accession>
    <name>A0A2X0MML9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C028g10510 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C028g10510</name>
        <name evidence="2" type="ORF">BQ5605_C028G10510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000080">
        <property type="protein sequence ID" value="SGZ12496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MML9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ12496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="433" mass="48170" checksum="449328CDE9F69EF1" modified="2018-09-12" version="1">MQAKRQAIMSSNLLWSAEEKADYGQWPLILGDRRKADEWTLKDTIPILKLPLYMAIEEHEWTACKYERCLAVIETLHGAPSISFHQHPADHLTFVDDPNIPSPEQNFANCLKNIVPFITARAEGPIPRVTGGSDRLTIPYAEWERVIVKPRVPKKGDLMPRTEFTRQPDGNACGVCVCRTMETLVAAVAFQSELDWSWSPLKPLQDNFYANQRAYMLDVVKHARLRCDTELEANPEPPTPPPPPLDLREGSGAPPPIPESIPLALKESSPELEEKPLGSPGIEKKIPSNPDAQCTVPLISRSPRPNPAPSIATIGSMPDAPPMRLQRVVKFDPTNSLPVSEALEVVACLPRYQTRTLSGKHPFSKLRGFAEALHAMPGSQCNSDVGVNRSRYGLSHTASDPSLSPEHSHWSWFILSSCKKRSEVVDPKPCHYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MMX5</accession>
    <name>A0A2X0MMX5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C029g10601 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C029g10601</name>
        <name evidence="1" type="ORF">BQ5605_C029G10601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ14548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MMX5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ14548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="88" mass="10075" checksum="B55FBAA3444340A1" modified="2018-09-12" version="1">MSVEELADSVYVLFCEGSPNLTELDKCRPMIVKQNRIQKMLRWLINESKNSAHSAVSFDGDCTARSTQFRPGRYRIDKSRMETVSCPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MP70</accession>
    <name>A0A2X0MP70_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C022g09558</name>
        <name evidence="11" type="ORF">BQ5605_C022G09558</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MP70"/>
    <dbReference type="STRING" id="796604.A0A2X0MP70"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1070">
        <property type="entry name" value="Translation initiation factor eIF-2B, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051501">
        <property type="entry name" value="eIF2B_alpha/beta/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042528">
        <property type="entry name" value="elF-2B_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="302"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="320"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGZ22900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="414" mass="44129" checksum="B6691B426B585C4A" modified="2018-09-12" version="1">MGSPRSPRTPSSPLAAGSDGPYSFTSSTSTPLAGSCSSLPTLHESTTLPPREPMDVVTYYADLLASDDSLSMPIAAIETLAQLISQSDTSTTTTELFSLLDQASTRLAQASFNPISLTCGTSLFLRFLTLQRPSPDTSFQEFKAELVARAREFVHESGRCRQLISSGMNEFVRDGALQFVVQALLHAAQQQKNCFQVYVTESRPFGLGLKTQAILSRAGIPCIVVLDSSVAYIMPKCDLVIVGAEAVCESGGLVNFIGSYQVAVVAKAMGKPLYALAESFKFTRLFPLSQYDLPTSLPNPPLTFPDFTNTSSSIPDARESTTTTTTASDSTLDPSSLSPFSEATSSSTPPPPTPSRPMINSAIPQALEMTDQMIRNNPTLDYTTPDLITLIISDLGCLTPSGVSDALLSIFGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPA1</accession>
    <name>A0A2X0MPA1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C021g09378 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C021g09378</name>
        <name evidence="5" type="ORF">BQ5605_C021G09378</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000083">
        <property type="protein sequence ID" value="SGZ21538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MPA1"/>
    <dbReference type="STRING" id="796604.A0A2X0MPA1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF31">
        <property type="entry name" value="STERYL ACETYL HYDROLASE MUG81-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="4">
        <location>
            <begin position="132"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="474"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGZ21538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="547" mass="60183" checksum="FB555B3B2C5D0D18" modified="2018-09-12" version="1">MNAPNEAGTTPIPAEKRHLALASGAKPVRMNLMLVLHMIFVVLPYAFVKLPLEIILSHIILRFRSKMVHLIGRPWYADYVRRLTQFVLSRTTTAQARVIFNRTNAYTLAYAGVAFIGYKDWVTQISVNGTTGGGFLLDTGGNAQNYFLYLAKELNLRRKVKFSIFQLDYELAPEFVFPSQLIEVQAGYHYLVNNQGIDPKKIVVAGDSAGQSFAELLLPPPCAGLTQKTKQKTSRAGGNLATTWLLHVARPCSSITVPESLGPTPPRPAGAFLISPMVDLCSYRPSRKANNKYDFIDNGGAFRAALEYIGVSNSAPIGVPSWNPIHFFQFPNAHPPRGFNKAPKFVAGKEVKGLELLGSPYANPIVCEDLEWLKEAFPDDGRTLISWGGMEVFNDDIEEIFKRMEKAGVAPAKSFKPLGAHDWILFDSFIPGLHKTHSFGPDRVATHNISVVADFLQSFDVRIRQEYWASAKQDVKSAPQAKEQASVPNPEPKTERVTAPAEETQVKAPSGTNPAKGGEGTKAGQGETREKSLEGSGVMVGREWGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPB2</accession>
    <name>A0A2X0MPB2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="23">BQ5605_C025g09955 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="24">BQ5605_C117g13262 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">BQ5605_C117g13262</name>
        <name evidence="23" type="synonym">BQ5605_C025g09955</name>
        <name evidence="23" type="ORF">BQ5605_C025G09955</name>
        <name evidence="24" type="ORF">BQ5605_C117G13262</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000087">
        <property type="protein sequence ID" value="SGZ26791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000103">
        <property type="protein sequence ID" value="SGZ30156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MPB2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0229">DNA integration</keyword>
    <keyword evidence="18" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="16" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="15" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="16" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="17" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="22">
        <location>
            <begin position="525"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="788"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="951"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="21">
        <location>
            <begin position="798"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="SGZ26791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="SGZ30156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="990" mass="107843" checksum="8AF5022181F5B840" modified="2018-09-12" version="1">MDDTSPPLATGVHPTFPADQLAALTSLLSGLTTAASGTVTTTTSSSTTRPAFPKHARLDGPKTFANWTRQLRLCLADDIRSYVLDGIVPVDWTPSQRSARDVVARELLANSIDSAEVSAVLDAIPTADLTAPKMYSTLKSRYAPDDATRTLELFSRLWSFRPMPGTVGEFDGWIMEFKAIAQEIIDTKPTINDVLATLLLAIAHPSLESFKASFTNEQRTQRALPAIDSLADRMRVQLRSTNVPSTKSALLASSSCPTRPKCLACRSPSHRVAECPVRAKHPPPGPCRSCKQNHWSFDCQQALENGKKADTANSIADSQHHVGCIATSLLARRRQLRTNSFVVDSGATSHMVSDKSLFTTYRHIAPTKIGGIAGGIHAIGTGNIAFVAASGHPITLTGMLHTPGLFVNLLSVSRLCDTDDVRVAFTKHGIDIDKDGNNIAEGTRLEEGLYLLDADHSKCQHLALLSRSQSSVPLLTLHRCLGHLAPSSIQKMVAAGLLEGLGAGYSDEEVEKFVCNACLSAKGHRLPFPDSDSHASERLGLVHSDVLSLPERSLTGKRYLVTFLDDYSRKLWAYAIGHKSEVFSVFKTWLAEVELETGATLKVLRTDNGGEYCSRAFTEFCKARGTRRQYSIPRTPQQNGRAERVNRSIVEGILALLADAHLPKTFWEEAAAYFVYCKNLVQHSALDKATPNSVWQGGRTTASALHPFGCAAWLTVAPELRSKLDPKAVRVLFTGYDLASKAFRFYNTATKKVTLGRNATFLDTEFPGLRCDSAEQDDDTHFASAPFADPHTTVKPWTPLPQAPPDPLDAQPPDFSTYREPASAEESPDELDLIGRHSCDESPDEIDFLARHHRAFIATDNDNPEAEAIQPVKSITSDPQTWREAMSSDKREVWAKAATAEFNSMRDDFKVFTIDDRSTVPAGATVVTSKFVWKTKRNALGEITGHKCEESTLRSAQDLGARSEPGADLGARSEPGAPAQDLGAQSEAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPF4</accession>
    <name>A0A2X0MPF4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C024g09804 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C024g09804</name>
        <name evidence="2" type="ORF">BQ5605_C024G09804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ25942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MPF4"/>
    <dbReference type="STRING" id="796604.A0A2X0MPF4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="555"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ25942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1165" mass="127090" checksum="83360DD476AA8E81" modified="2018-09-12" version="1">MGVDHQQLFYQLRSTSTPLSDKLQLINSTLASSSSSSASSTALGQLLRDWIIELFLRSKHVDQTILSPQWWQLLDSLSTGTSTSSSLSLPAAPTLPILTSFLTHYPSVKNLPSDQAVELVSHVAAVWSHWSTSALRKANIDQALDSYSTLLNSSILVLQRAAPDTEPWQQLGLIHIQSLNLIINSAGKGSKKVASHALSSLSSFLPTIQLLRSSSPLHQALLRTLQSSLFNVENLRKGLARESYHANSSSSGSTVNGATATGGAASLIYDENGNRTESAAGELLAVLKGMHDGVGPEAQVKKKNVLEIIFVLTRLYFDALATHALVLFPLPSSQANHFATPSAARSAFELHSLTKRRHLAATWTRGVCLNLLQWIHKTNNLGSELDHLKTKCLSDVLTVIETQDLHRDGKEEGWEGCLEMIVLGAMNRLDDDTSFEVLSLVTRMNFDAVSPKLEKGLKYLSTTPISTNQNHRGKQEWLHTLLSHYSKSFTLLPFLHHISQAIGSEASHNGCINNYLTKIEFLDALRERLGGIVPGLGVKDAFEQLSQGIRAALEEGETAQPVEPVEVEQEGRTKKRRKVSSSSAVPIESNTVRASSSTAALIGRSRILTLFIQALPTPLPLEHFGLFNKDVLEPFLKTSLGSKHASREEVVAGVELLRVREAMLERMRFEGIVEAEAEWALDKAVNKRLIKLVQDDEEGFVAVEVARTLLQGFEKGADKATAEHVIDTISSRCAPGSTDGRAWDGYLRRMDLGQLPTALWELVTRRHLALFERLGSETSLWSIAKKIVSNITTDQVKDEDLTIKSITRRLLRRADLYELPRLRQQFHLALSAITSVEGLQAPSTVLKALSASKVPKSLGSIKPSKLVEVIGLFGSIGSMLPMQYLGKSLRNELVERAFGLDLWIGGGKSGVERELVEGLQIGLRKFVILVMEGGSISPPSVAVISRLISSADLEASREYLTTINDLYRNLAQSAIVSFKDTSSPARLIEMVAAFEKPLSGLSSRFRRGGAQLMSEEKAYTTLLDVLVVEGLGRAEGLPEGLRTAIASSVQAVTNPFGKTLKAATQQVVSEPKMVFALADLINSCCSIWRAKDWLANDASECDEVDTYTAFAQTTLGATVSHIVSGQANTMAAESAIAATCLAIAELLAYRIGRTRTMSKDLKVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPS6</accession>
    <name>A0A2X0MPS6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C017g08531 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C017g08531</name>
        <name evidence="7" type="ORF">BQ5605_C017G08531</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
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                <person name="Wedrychowicz H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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    <accession>A0A2X0MQ90</accession>
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        <submittedName>
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                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
    <sequence length="1375" mass="149523" checksum="58FF4230218F8197" modified="2018-09-12" version="1">MSSSSVVADSDPACATALPSASYSSTTVTTEGPSILRAKTATRTYGKPRPVLDEDLAMGVSNFAAATSAATTRLERVDACLITRKTSLVVPESDLDPAARDADISSSYSSPQTHRSIERKRKAISSSSPASGRRGHDSTDPTSEEADGDPNQTVRQSKDRHIIVNENTPAPSSSQSNSGSDDGDDQGGITTFLKQSNWKAELAKVDRDDYDFDALPKVDVEKSAQPAADTILVFSTQSTLTTLPTSDGPVADIVRGSTSIRPGVLSDDEEESDEGVAPRKPKTQRRVIDSDEDSDAEEGKARPAMIATSSLEDIDDVDEDAAPLSKKKAKGAISKKEEDLMHRETAALRREQDFRLAPRVKSAPKITEILKKTQHNRPFVVPTRKSFLGPIPTVPSKRAEAELLPDSSIKETSSSPSRASSPIEDTPTTTRRQVIIPSTVAQFVMPLKSVTTAPVDDDDDEDEELPSLDKVFEDQAKAAERRKYQELKLAAAKRAEEERVKRLASIAQEEEEDSDELVFEVVKPKPSARSRTERHATPTSDAHRLIDHNSVSRSARKIRDLDVNIQAANHDDDDETAAQTALLMRGRGKKPKGWVPQYKCIEFKKKTTTAEFDSIEALNDRLLGKAAMKNIDERTRKQAQARRKMEGVVKNDGGVAKVNVDHLLKTKEEKIKAAQQQEEEDEDAEDGDWAEGEEDDEDERGSDVEGDDEAGSGSEAGSGDEMIEDEAEDDSVAEDEEEGVSAPVVVKRRVRLQSASDEEDNDEEVMAKKSSFQAIKGVELPSFLDSQPDRGFSQFFDDDVSQAFGEANEGEGFRRRSTQKLAAEETASQEAAREHGLHITETQRMADNQALEERAAFAGDFSPGTPGPGYDPPPRVYINKEGLMTQTRPLNLFGAASMESPVGSTFSPLDSASRPRFSLDSSSQRPTGMTQTQLAATQTPTQASKDPSRLRRANAVIGYDSISELAATEVELASTEVEGAETQETERQESFPSAAQPIATNAFEIMRQAAATQQSILPALVEDMQRETRRKGASAFIEQEADLSDEEGGALGRLSGDEDETNLDDELESLVDHDEVDEEVAAEQDAAVNDLHAELAAKQDAADLAKAQAIADGKERTRRKGLDLDDDDFDDDYGISTKRAEKRPRVENLSTAQLQANEETRQFALNITEGLVTSVRPSDVDYLAEPEGAQSGSDEDEYDDDEGVSDVDGEGDSRMAPPPRKMSMREANELALERSRRKEKERRTTPLPEVRLGTGSSSPIALPRVKNRALLPKTAVARPRPSDEFASLDSQYGLVNTTAATRVVYKSSGDARDESQGSGKGMTAGKNSAVTSFKRTSLTLGSNQSEGSSMGSKKGKILSASSSRAMSFRRNAFET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQT3</accession>
    <name>A0A2X0MQT3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C024g09943 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C024g09943</name>
        <name evidence="3" type="ORF">BQ5605_C024G09943</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ26571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQT3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="324"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="402"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="502"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ26571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="563" mass="62369" checksum="78A7E90B0FCD8650" modified="2018-09-12" version="1">MGHALSFPSKSSSSSSSHEHPGLAPKTAESNNKCATSLPQSLRLVQPLQPSSTRKSQTDRDPNSDPALIRPMQVTKSSLAQPGRTKNFQPNTILPPKAQNESLHTSITSIPAGPSTSIPPLARNLPVSPALEKFRYRPPPEPTSEERSTEQASCAPHSPRKRIKIQTIPYHLSIDSSTPPTLILLPEYDEFGEIVIPDSQSSQTTRDRVYSLKITSRMIKLSTPELSSSIELPSQLARHIRLGQSSIQPRFQSIHGRGSDFGTQSSDPEEVDRYDEYQTDLGERETSEDLSRILEELEASGNLEADLAFSDDEKDELEAAVPEYAAEETDDRSQEPLPSAPWGSPKPAPKAFGSEANDIAPFAERRKRSQVHADPCSSSARKFGTDLLDLVSSPSGPLRALSSEAAKDKVQRPSVEPRTPLGPRTSPPAPPKANLIPAHPRNKCTSLDYLMAKYTPVPERPTHRLVPLTPEGLTTHLTRMLDSYRGETAATKALVESHQMIIDEQNDEIVRLRGKLRRLEATERRCENLTNRVEVLEQIRRGLLDMLEDKENECQALRSELEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MRV1</accession>
    <name>A0A2X0MRV1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C060g12727 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C060g12727</name>
        <name evidence="1" type="ORF">BQ5605_C060G12727</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000136">
        <property type="protein sequence ID" value="SGZ35422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MRV1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ35422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="133" mass="14817" checksum="87A82F54451F05E9" modified="2018-09-12" version="1">MKTIIAARCVVISRTDQPDTSEFKPPPTRGCSLPETNERKIEDDTQGIGKRVFFIFYFYFFGGKLAEGYFYFYFLTGAHKLQSFGLAGTATKRAKGGYKATTASSWVKVKPLRAKSAAQIKTRRAPNADSNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MSM3</accession>
    <name>A0A2X0MSM3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C002g01097 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C002g01097</name>
        <name evidence="1" type="ORF">BQ5605_C002G01097</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY29920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MSM3"/>
    <dbReference type="STRING" id="796604.A0A2X0MSM3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY29920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="662" mass="73419" checksum="7981568FF9D13A7C" modified="2018-09-12" version="1">MPTVATDQAGRDSLAQLQANGSGSSPRSTAALPSTPFRVDHLDVNALTEGPVPTSPSLRTPSGFEFVDLGDRSSMGDSRPRCFDWEVYGPDSPQSLNLTHASKQCFKRRLGPTEVSYYLGSRGEGVESGVNDMYLHIGFRAESHLMITERLLNIWTEITLRHQLLTSSVEYHDVHEIRFVYEPPTSMAEARRKAKSLMELRTRQDPKALLDTYLNGDRTLSDERLSYLIFSTPEASFDAATEQEYDMYLFSAHFLGDGMALHTTANEIFTLLADNADATEGAAAVKNLEAVLREQAVKPIFPEVASVVEDIDDVGDAFSAFPVEKLPQAMEAKLVTPEGWGRMAWAGARVEYNQSQAKLIGGHAFPRAKLGERKTLVPTVAYDTAKTKKILSNCKIHGTTISHAVFSLSNLAYIRSTPQRDVELPVMIYSALNMRGNLTKADDDWYHIAIGYYNIILPSFLPSTISVERTFWHRSLVVRKQTSAVVKGRWLAPRSKLMALERERRSIGFEREDERRRQQKLASAELPSQLQGLGISFEDDATESKLASNLAKTLAPVAPIVTPQLAESTTSPKAPSTALMGLSMLGNLDAMYAHKDYHGIQMHTLTTGSRQRAGAILLFAYTFVGKLWLSLGYDSNGFQQGVIESWWTEMQKGVDELLLPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MSS2</accession>
    <name>A0A2X0MSS2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C002g01157 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C002g01157</name>
        <name evidence="1" type="ORF">BQ5605_C002G01157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY30487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MSS2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY30487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="184" mass="20973" checksum="7D356E026927FFD4" modified="2018-09-12" version="1">MTETAPEAYDVNTREIGRPKTRCSSFTRDRHSVYSALREGFEYMQPEVVIYGMCIEYSSFVVDSAQEERVSFRVLGTRLRPLWGRVVALHWMLNHTDLPWNGERTSEDVISRRVRSPPSPVPAVFTMRTKRPGGAICLARAIHSFTVEFSHVGGLRTDFRPVSTARKTANTRMNFTLILIGSFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MUC3</accession>
    <name>A0A2X0MUC3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C002g01717 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C002g01717</name>
        <name evidence="9" type="ORF">BQ5605_C002G01717</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY35029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MUC3"/>
    <dbReference type="STRING" id="796604.A0A2X0MUC3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050453">
        <property type="entry name" value="LIM_Homeobox_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208:SF166">
        <property type="entry name" value="LIM HOMEOBOX TRANSCRIPTION FACTOR 1 ALPHA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208">
        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="61"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="63"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="156"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="338"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="467"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="241"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="283"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="442"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="479"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY35029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="578" mass="61888" checksum="9513705D6AF8982A" modified="2018-09-12" version="1">MQAYASFAGPSPRQSKMARPPPSAGTSSAFHPYQSPKPRSPAQITFINATTTAAEGFEGPGQVKQKRKRIMPEQLEHLCELFDRTDSPTYDIREQVGFKVGMSNREVQVWFQNRRAKVARQQAAEMPPPPPRMEPAKASSVVKPSPITSYTSRFAAASEGYSPSEGAQWKGRPYAADGHPGSPEEGLAHQTALLRASPGPAPVRPSGFVAAEPDGLGQAVPTKRRPDEEEGQPYPTHYQRPSPSLALPLMSPSANFRSPGSSGSLASPSLGSNYSPFAPLPSPSQASSYQGSQTFGTPSGYSTSGSSYISGSDVPFSPVSYCSSPGGGHFFRLSLDSPGVKGASPRASPRPGMFDISSLIPSGPPEGPIQLRPILSPDIWDERHRETMRERQRSSDRPQDEDDDAQTFGSRVDEINMEAMSKTEDSLVKASKSGLGQRRPHSSPTTLSPNSKYAQLAYSSRLAADQSLRAQNLGRRHTISQPSSLSTSTAHQTDEDGSDKLTDDQLAVLLGSIQSAQPAAEPLGLGMLAVAASAQSGGGDEEDEAELRARERYLATRRLSIAPTALVKDSMGRGQQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MVY5</accession>
    <name>A0A2X0MVY5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidophosphoribosyltransferase</fullName>
            <ecNumber evidence="3">2.4.2.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C003g02359</name>
        <name evidence="10" type="ORF">BQ5605_C003G02359</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="3"/>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY40359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MVY5"/>
    <dbReference type="STRING" id="796604.A0A2X0MVY5"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11907">
        <property type="entry name" value="AMIDOPHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="9">
        <location>
            <begin position="2"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="550"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY40359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="593" mass="63755" checksum="FFAB31AC23FD50E2" modified="2018-09-12" version="1">MCGVLGVLLADQASNSAGELAEGLQLLQHRGQDACGIVTCGPKGRFFQCKSNGMVRDVLDAKSLSQLIGSMGVGHARYPTAGSSAHSEAQPFYVNSPYGIVLGHNGNLTNTQHLRYYLDHYAHRHINTSSDSELLLNLLADALQKTGKFRIDSDDIFRALRDVMHTTSGAYACVGMIAGFGIVGFRDPNGIRPLGWAKRKSETIPDGYDYLIASESVVCDALGFSEWVDVNPGEAIIINKTGVVIQQCMPPRTFAPDMFEYVYFARPDSVLDGISVYRSRMAMGDALAENARVRLAEAGIKVDVVIPVPDTSRVAALQVAQKLDVPYREGFVKNRYVGRTFIMPGQEIRRKNVRRKLNAMALEFNQKVVLIVDDSIVRGTTSKEIIQMARDAGAKKVIMASCAPPIRYPNVYGIDMPSRFELVAHGRTEEEISRTIGADLTIFQTLDDLVKSCGQFNPNIKEFDCSVFTGQYVTGGVDESYLVGLESLRSDNAKIKASAAAGRPPLTNVNAANQKETGGAPVIASEASGVEGASAVEDLGSNGASVVTASGAMNEVHSGTGDDDSQVVGLTNAGQHDTEHPDLSVGLSNLGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MW29</accession>
    <name>A0A2X0MW29_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C004g02842 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C004g02842</name>
        <name evidence="3" type="ORF">BQ5605_C004G02842</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY68039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MW29"/>
    <dbReference type="STRING" id="796604.A0A2X0MW29"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF14">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY68039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="968" mass="105597" checksum="C4F7F3186D8077EC" modified="2018-09-12" version="1">MMPSYKPSAVLYDILRDDANRPRPRGGDAPTLLGFLLVALALTSLFLGFPSPFASLSGWVHEPTHDPATLKRWDDTLLRCERLDRLPGPPSSFNSRTESDRFVSGTKPTLIRNATIWTGAAGGHELLQATDVLLDRGLVVDIGVGLAAPAGAVIVESRGAWLTPGIFDMHSHISVDALPKLSSADDVNSLAGPVLPWLRSLDAINTHDLAFKRTVSGGVTTSLILPGSGNSVGGQAFPIKLRPTKEKTPDSRVVELPYNIAGNKAVWKRDDPPRWRHMKMACGENIRRFYQQTRLDLAWNFRSAFEKARKLMEEQDTFCIGARTAKKEGKVVTTAFPDDLQWEALVDVLRGKVKVNTHCYEVTDLAAFVRLTHEFNDLPSPSNNRQRFLFQFHHAHETYMVPDLLKSAYNNTPAVAIFATNGRYKREAWRGSEYAAKIHSENNITVVSCRISQRPKAHNTHVNFLLFSCTMSQIVKSDHPVLDSRFLLFEAQQAHHFGLPEHLALAAVTTSPATVAGFSHRLGFIKKNFDADVVLWDSHPLALGATPLQVWIDGIRQLDNAFTAKELDVIIQAPPIASIPNHIISHEEDDDGTQQGTGAQTVDGVVLFTNVSEVLLPRNKSTAALTTSNQAPLEVVVRSGRIECVGRKGECSNGLGKGAKGVNLEGGSILPPLLAFGPALGLTEIVSEPTTTDDGVFDPLYSGSLSSLQQIWGPHVAVRAVDGLEMDGKHLRTAHQIGITKAVTAPMGSGFFRGVSVAFRTGAKNSLEKGSIVKDAVALHITIVPLVINAWKADHLATLIHLKQEIEGIARSNEGGRPLKWIIHGGQEAHLVADELAQADISVILSPSRSFPASWDERRAVAGPPLSPQNAATILHLAGVRLGLGVPEEWQTRTLLWEAAWAQKTSSGHISRAEAIKWVSSNLEGMLELETAGDGEHANWVAYERDPFEFGSRAIAISNTQWGHVEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MXC3</accession>
    <name>A0A2X0MXC3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C005g03284 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C005g03284</name>
        <name evidence="2" type="ORF">BQ5605_C005G03284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY73346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MXC3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY73346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="224" mass="24416" checksum="540D9E82C17E8F99" modified="2018-09-12" version="1">MNMTIAELLAFDVAPADASLHIELSKDEHTQYSTLSSTRCPTSSCSTQGRPMESSDPTRGEAGVGVSNTEEGRSAAHSCVLKRLVQSMGPSRCEDMAGTTRSFRWTRGDQMDRALTTHEDPEEYKQYGALAQHYPHFGSLDGAVTAATPLEIGSLICFGLKFGMHSLSCDQTVYGEEALSIGIGTLFDNKPLQPRHIRLVGSTLKCRRTGASPHQETMLFHTPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MYS2</accession>
    <name>A0A2X0MYS2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C008g04975 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C008g04975</name>
        <name evidence="6" type="ORF">BQ5605_C008G04975</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY78858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MYS2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000146">
        <property type="entry name" value="Putative two-component response regulator SSK1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="1424"/>
            <end position="1584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="78"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="196"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="484"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="621"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="893"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1063"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1171"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1285"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1597"/>
            <end position="1623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1648"/>
            <end position="1847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="78"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="256"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="492"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="901"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1092"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1118"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1178"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1199"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1218"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1296"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1355"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1375"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1604"/>
            <end position="1623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1668"/>
            <end position="1677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1686"/>
            <end position="1699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1706"/>
            <end position="1732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1790"/>
            <end position="1802"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="1473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY78858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1847" mass="192804" checksum="DD400921A42C4DB9" modified="2018-09-12" version="1">MTDSAEHAGFNNASTSATATSSSPAPVASTSTSTSSLDNVENNSTRSSGGHALGIRPSIIDVQPLFSSDVRSARSIALATAAAAAAPSTSTSPSISTPSGTGSPPSPPIISSLRPSTSSTAASSTSSLTERAAASGSRDRSSSASSSAGDTTRSTRRAFNRRKTGYGTGKYRLQELCANAANAPSTSTAGTFLTRFLGSFRSPPPEQGSDDGSKDVSKRPLLPRSLSNPLQSRPRPPPDGPRSTSSIPSSRQAHRPASPLPASAQSSRPGSFSDKLNIRRVSSDLVGASRELSRPTSSGSGAGSGSAQAKHRFQPSFRRLSSTGTARDSQAHSSMVSPFLENDVPLPSPISPASTVRAGKERDPMERTSWYDASRVPRRGSGFSQKTLLPGRTPTLSASNSFPVLGPILEPEPVSSATLDAPLSLINSLIPAALVMLAQLGPSHLFSPAVISGDYSGESFSAPFTSPYMSSSAASRTTELPYPASDRASIASSVTSKTSKTSSHDTGGMFGSTMSHVATSHSHELHAPSTVSLPAVSVAALWRLLRGLEWITGVQNKESTNMISQSAPNKDHDFNSDSTRIAGDANEHEAAPSFDFPSMLQGVADVLAATAAAKHIEIIVGRMGQSKPPSSPSTPSMSDSSDGVRKPAACATLDQRSESRECLVQGDESAWSIALIWILHDVISRAPSGSSLCIRFQATPASSQSVELSPMVEQPIEDANQPTQAYIKTRLRSDQMWRVSTGIALVRTTPDSPAFEAMSPVDPSSPSPLAVRKAQAILDHPDLKAEVRTFESFDANNSWTIEGVLAGGMPAESSSATEDTIFGRQRVASESHEVSGRHEPIAEDLIRFARTSLQGLRVALHAGENSSFAKHLTHHLAGWGMDLTHIALDHDEAASTKSGRPRFDSGDHSNEPLNSPLRKLGLADGLSLSSGGVPSDLATDPASSLIVIDDDVTTLRRLLYTLRALPLHYHQALPTKRPQLATRRTRSSPHVRQITQVPQTQATCVIIHFASLTQYKTIKELVQDALAHTKSPSLPEVLVIPKPAGPRRILTALWTALKRPSIDPSLPPIATSPSAPGVQYWSPKLSPAVGGDEGKPELASDRGEGNVSSGNANVRVHTPPTSSLPSSMTNGHPPSPLETISDDQMSYFSGMAQNMDGATPSEGVVFQSPNGRPAIFFQPSTRRVSNGKTHRDREASVPSVRSRQGSQNTATSPKIGEPFASPSSSQAAPVATPHEIGLGHIRRSSSGSSSTSPKNESPHLIPIGTPALTLDSFILSAKSRAAGEEDPLLMADPGTNVPSPRPSDSLQRQGSSASLTTHRLTAPTPSSIGTGAVAGSSSPRMGPSGVSAAAARRVGSNTSSTPPSMSPSIGGTGTASSNKTATSAPATPQTFHSSPPRRPTAGHSPKSRRRPSRKVTLPAVPPINVLIVEDNPINQMILSTFMKKKGIAYAVAKDGEEAVQKWRAGSFHLVLMDIQLPVKDGIEATREIREMERANNIGTFITTPTTDIASPISSASSSLPSSRSSPVVGSPISPLQLNMPVIIVALTASSLQADRVNALAAGCNDFLTKPVSLAWLEKKLREWGSMAYLSGFSAFPSDASPSSVRSITLTTPATSRSLSETSKRSFVSGMSSKAAIISLQLHIAPKATHAATPTPPGGGLGRVNDSGNGSGSAGAGAGIEEHSDGTMKSQPVQATTTERNFPVSPSEATPSDPASSATENPTVTIQAPTPETSLAEEPSASKDVPKVPSTVAKDTPSSRSATDDQDGEAPVINDETIGTVDNKLRHLASVAQQGSSEPSNDGSLLLTPSIMASKRPGPSPLAQSATASYEDESASHAHEVSPPADSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N2J2</accession>
    <name>A0A2X0N2J2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C004g02664 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C004g02664</name>
        <name evidence="1" type="ORF">BQ5605_C004G02664</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY66358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N2J2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY66358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="147" mass="16372" checksum="3EF86F446D9836F0" modified="2018-09-12" version="1">MPGNVSASVFPKTEASTLGLGLRTGAGPRLTIFDLLLAPELLTARQKALLKQDAKAQSLILNYLDSDNAVTARACTTSNEMWKSLHDNHVGLISDQVRFLTAQLRNLQFSKGKEIVKHFTTLQDLFTTRQYRETERRGVATCQRRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N722</accession>
    <name>A0A2X0N722_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C022g09543 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C022g09543</name>
        <name evidence="2" type="ORF">BQ5605_C022G09543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N722"/>
    <dbReference type="STRING" id="796604.A0A2X0N722"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="735"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="831"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="743"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="765"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="775"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ22794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="853" mass="93452" checksum="836DA222997CC4C1" modified="2018-09-12" version="1">MLEVSYSNSSALSTKHYKLVNDLEHAQSDEETLRIVLRCLGEIKASWKKGLNLKPSIMSHDLILVLYCYETIQGLERTQLTLEEKGCLDWEMWLIGAVQLAGRGLGTTEEERGVDVGYRVCDGLFPPVRSEGNDGTPHDDDQEAQHPLKLLLVNTIRADLFTPLSYPRAEARWVLGLRAAASDRIAGPELVPAIAGRVVELLGGVEGINSSIRRLALEAIQNLLEVGPNARLLEKTRKIIHTSLMEFSPAKGNIREEVSEKTKGKRRAFLETDHELESVGSKKTFGSMRGKELDPKLVLAFVRATSRRTKGGLYPIFGGEQEGGAIMEVCLGIVGKVVDPLSEREGAGWDDKAFECGGLKCVWLALGVLERVVEELREGVVSEEMMGRIAWEVVKVAKWTEGGRKGVRDDLDSLLTPIARSLQAASTNSRLFALRVLSLLPTILWSTLSDESKSWGPQAWSAIMRGLDDADAQVRKATVRVLRKVEGDLVGMYWGRVAEGVKGAAAGGDGKGVGLGVERLMEVIEVTKKGGEEWARAIMELIRLVSGLGGVNGPMGEIVLPTIERFTYTSDKRVRHEFAKALLDEQEVWSGQITLALIIAAVVHALASPSSSEEGDGDRAIVDASKKMLAFLDQVLPLAQELQEPFLVALLRLSGSIVDLQVMKELHSLVQGCGERRATFATRPLFETLEMGLQEGSVERGVVKGMSGSKRYEGLMLPAWEGVFRGLVGKARRDEMRGEERFSTSSPIQTNATQGRSTPLKYDPYTTSSVDSRPSTQTLNLSKSSTTTSLAEQIGISPRALARERQDLLRDRIERGGKGGMGESLMFEVERQVQEDEGREVGSRDEGHPFGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N9F4</accession>
    <name>A0A2X0N9F4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C035g11450 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C035g11450</name>
        <name evidence="7" type="ORF">BQ5605_C035G11450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000064">
        <property type="protein sequence ID" value="SGY98215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N9F4"/>
    <dbReference type="STRING" id="796604.A0A2X0N9F4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000007">
        <property type="entry name" value="NAD(P)H-dependent D-xylose reductase xyl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="17"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="5">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY98215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="322" mass="35516" checksum="5EDBC8229750D010" modified="2018-09-12" version="1">MPVKSLKIANGSMPTVGFGLWKVPKPQCADVVYNALKLGYRLLDGAADYGNSKEAGEGLARAIKDGVVTREEVFVTSKLWNTNHAYEHVVPAAKHELSLWGLDYFDLYLIHFPVSLEYVDPNTRFPPEWWDGKPGGKVTPSNDPISDTWRGMEDVHNQGLAKNIGVSNFCGGLLIDLFRSAKVKPSVLQIEHHPYLQQPALLKLAQETLGMAVTAYSSLGPQSFLELDHPGAVKTPSLLEHDVIKKIASKHGKGEGQVLFRWATQRNVAIIPKSNNDKRAEANLASVEFDLDAEDLKAIEKLDIGLRFNNPGDIDPRLAIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NBR5</accession>
    <name>A0A2X0NBR5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C045g12208 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C045g12208</name>
        <name evidence="2" type="ORF">BQ5605_C045G12208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000115">
        <property type="protein sequence ID" value="SGZ31585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NBR5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ31585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="457" mass="48282" checksum="BDDD20450806F334" modified="2018-09-12" version="1">MAERVDGDGDDDDDDADDESDDNEPALTSTTTPSRPTTGPTTRRIRSGYDTRLGHYDPFGVGRSLDGVTPADLSAASSTSPLPSLSPSRPPLFDDSDEDDDEDETSRIYYLSNTDDEDNDVLCTPTSAGSGPVRRVSLGLLREPVKTMAVNDPLLSPPPPPMPILTFGRQGLKSAWLPASPLTTSSVSPTTTPPTITPATLPSFPAFLSTSPPSMTSSILTAERVRSTSGAWDATVSGGTTSKPLSPVSLPPPTTSTTVPKVSLLTKSLRSLAISLPNLQLPGLRPPLLSLDLEGLDAGERAPWKRPRRASFGAVDSSLAIAGATPSVESWAENADEVLTMFQLQTFSAPPLASSVNSRQDPASTSTSADRSAKKKSAVPVSPVPIAPAPTVMMPRYVSNQRHLLMLSLELEMMRRHKISAPLRGRAVVVRVATPPRGSSPMSSGGSGLRWEVMPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NHN4</accession>
    <name>A0A2X0NHN4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C047g12338 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C047g12338</name>
        <name evidence="2" type="ORF">BQ5605_C047G12338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000113">
        <property type="protein sequence ID" value="SGZ31224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NHN4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ31224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="510" mass="56679" checksum="00EDB6BFD65EE818" modified="2018-09-12" version="1">MLERLSRSAPSILPSRQSSSGAVGSDVLIEPGSVSSPLWPLQGATSTCSPPIASAVSRGLVSFGSVRSHCTFTCRTHTFLLKLDKTTVRTTPEASPWFYFADTIAPTGRTSWWRVKWKGDEALFVIHEEPLTSTHKRDRCSACQFINVGASSYFTSNERSIDSTQSRHWTVLVRRIFECVDSSDTGSCFFRITLRIGDAIRLATEGARIKETKFHLRRHPYDLRFLFTKTGRILYESSTFLKNASGYWEDLLGSGFLEAEKRAPDPHGAPVRPLTAEDTRGDTVTPNREASRGCNEPMHTIEVEEDDFGLFDAYYGMLQWLRGCDIIFGPVLEDDFRAMLSNSSVAAEGMAVDLDEDSEDEDLEGEAAEEEAVEDQPEEDQHEEDQGEATNRRPCTSGDGEHPCPPRPVAPEVLYRLAHRFRIPKLCAFTRKTIVSQLSGRNAAIVLFSSLCSEFPAVRNDVLDFCVKNWNASVATSAGMIEVRQRIGRNALDIGAVEASIILFELNDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NIP6</accession>
    <name>A0A2X0NIP6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C041g11973 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C041g11973</name>
        <name evidence="2" type="ORF">BQ5605_C041G11973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000119">
        <property type="protein sequence ID" value="SGZ33524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NIP6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ33524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="292" mass="31783" checksum="95D8C299DC37C608" modified="2018-09-12" version="1">MAGSASEKDKENQRRNGKGTGSGSGSGSGSGSGSGSGLGSAGSGSSAQASGGLKLGPSLVRAKKYIDADGMYARKDKGNMGLRDYTCKRGQIDKIYYNWQVQRAEPHYRLALTSLCHSTPTPVQLYGPLAEINQEWSPNHDLPENYDLKDAFRLISAKTSTNTVLWGNLSPLKQREIVKYIRERAGFLAVTSGDWLYEELVIDVLANIRSAWKLAHDREVCRLAGIKGQLSKADIATLRSRHGEGPSRKVSPFFSTRSNWMVCTDRSPGNTHSDGYSPPKTSLSDLKLIELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NJ72</accession>
    <name>A0A2X0NJ72_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C060g12731 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C060g12731</name>
        <name evidence="3" type="ORF">BQ5605_C060G12731</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000136">
        <property type="protein sequence ID" value="SGZ35436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0NJ72"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1268"/>
            <end position="1553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="650"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="712"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1853"/>
            <end position="1878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="713"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ35436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2097" mass="232413" checksum="13BC084336345FDE" modified="2018-09-12" version="1">MQTGDPGSAPGARAPPPPASAPTSLPIAGTKETQATQVAGRTATYAAATNSSVVSNETPAQQQDRLASLQALPGILAAIQAVPGNRADRFVQAIFATPDFPSTVATALKFSALNATRNIINPFANALEVSLSHKSTGKASATDKGELVACVRTLLSPNTPICFDTGVPLSGDLEAFMPRITGLQHSSTFRTGVLHHRITVGFVSAEARDAALASAPMLVWNSANARFAKAHPFHRNMLEMRINVGVVRPPSKEQIVAAFQSIVQQLSTKGHSCQLVQVLRVIHVDTAKAYAHTVGDFSAFIHFDDASLFQHPTTTLKEILPSRMDLPTRGLDVTAVRHDYEKEAPCARCHFAGHVERCPLMQAANRKEAEDLARHAVMRGAGMVGGGEQTGVGRAATTTTNNIRPTANNNNTSEVVAPSRALGTDQLESRNRFAGLEVEGGQEDDIEEEVAGKEGEEKEQVKEGDEDTGAKADDEDSDSDGNAGAGIDKAGGDGKDDDKDDDEDDDKDEQDDSSEGSERRGDDVMKDGAEEEDEGMETEVEEEVEQEQGVQDDSIMIIDDGQTTITTVSRESTPRSPSWPPLSPETLAKSLREGAEWDRANAEAAARVQAENEAIINAQLDAQEPLVRHQFAEWGQEDGQLRFINIRGTGSRSNKKMKRSQTVADLSDPSDDPVDVKRVLNRVKGRAGKEVAGQGKRVTRSMSAAAAMQVEGAKAKAEKGKGVEEEKRWSDHEPEDDILPEFPLFEDNITAKSTWNVRRCMGIPEKRRDIYTYLSTFKASAILLQEHFIKPELWQCIKDEYEGKAFISKHCLTLIPADSPLIDAEILRTHSALDGRILVTSFRLRGDIRILEINNLYAPVDTKQRLTFFDKLHFHRTQSTHLRLLGGDLNDCPLPAIDRRNQGRHGHHWPILIGKLDSPYTDCIRFKHPLTPSFTRPNIVRKRPKSFSRLDYFLLQRTHQKRLVQASTIYDHPKDLSDHRPVSIVLVLSDERGDAAQPNNSLPTTSNQLHRINAATFKTAAFQGMLEGWLEGASGEEPVGELEVVLGNCEKEGRELARREHRERVERMAVLVGRVQDLEALPVMGDEETAEWTRTTEELRRAVNERARQLRIRAHVPEIATEERLSRPVHAKLAARSSDSKITALRLPNGELTHDIDVALDHTQAHFQRLYNLEPRDRDHVERLRDDFLAPIRSARTCDDPSSDPLFLRRLSEAHIELLQQPITEDEVVAAIATTHPGRSPGPSGVPYELYHTAPRAWAKALSRAFNAMTERGSLSPRQGQGLVRLLFKHHKIGADRAELSSYRPITLRECDYKLFTKVYVARLNHVLPDLLPPQQHGFVKGRRSADASFHLRLLIEELGARGTEFPDAALLSLDQSSAYDLVEHEWIFAIFDALGAPATFQRVLRMLYSGDSTTARYIINGFLTPPVRLTCGLGQGDPASSSVWDVVFQPFLDALHRRGIALNLSLPTIHPYPQSRAITSLAFADDVVVAVAGSESLTLLDDLALDWRLATNGRLNTDKTVVLPIGCRWEAGDRPLVVKAEGESLEWIGLSFDPTGNTELANMNLVARLEANLGNGVSVDVERSGVVCEPPVPCRIEHRFEPCDEIHVGEFDVAGGVVKELDRILVDFVRGGKRRSCYGKDVVFTPRFKGGLGVMRMQDVVDSVAARVWDVLLGGSDAIWQGLARAAIVRAHPAPDFDLATDAWPCDYTPIRTDLHPRWQAVLKVPSTHNAQVKPRTLTLANLLALPIKLHTLHYLPGAPAVSRSPYDADYAAFANYAKVADLFRRELYPGGGFHLWTPPTDVVVSNSEYDQRGRPQREHIVAWYRHAINRLRFTPIAQPVAAVRINGPPRVRPRSEVRPTTPLESILPHPIDPPQRLPRPALPDQSTQYNLLSMDRPYTIRRVRRVLNAKAFTDTIGFRDSLQPDDLKGFWKGVNSKALTAREREVWFKLVRNFTPTRSLQFHQKHDDSPACLVCGAPKDDREHYFFDCVDSGNVWIAARSVLCDALGLDTIDNTHYTAVQRMFGLPKLKASLRDQEGAGRTIEIFTGLILEMISSGRWGMQKWGTRMEGVGRRRIILEERLKLRAGGAWGRRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NSB7</accession>
    <name>A0A2X0NSB7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C017g08418 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C017g08418</name>
        <name evidence="1" type="ORF">BQ5605_C017G08418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY19980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NSB7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY19980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="429" mass="47849" checksum="478CE4665BFE9D71" modified="2018-09-12" version="1">MHLLDTYNTSSTPTILPSIEERQFPHPIPNLRPVTIHFPVSSNPILCAGPGVYVPALPEKTYSGQIPNSSTPYQQPITPSCGSDLVPTFTHFSGIRPQTLHLLRASLFHLLLSLAFPQYGFSYPTMVPKPFVENDGTPIRNIQPLPHRLIISNLPAISGDISKQTAEATLEDLLSTAGIGPNDQPVFFESHKIGYPTGLSDPPQSRYKALHTDYFEIVGPENDIRFTTKIHDFLNANPYREWRKVPPQFNPQVHLLMAQFLKKAGPSTFDSPLLDEDGNVWPRLFAHFTDTKENDVRAPEDLLCKAVKAHIDKHFEDMLDVPAESCISITTESNARHDQCKVLVTVRLAGSTMVDKITASKARSTFSTRLNIPIRSMSRLAPQANNKMEPLLVEHTITGVFKRGCKSRTRSWSYGQNPTATPKVSRPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NSG0</accession>
    <name>A0A2X0NSG0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C011g06628 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C011g06628</name>
        <name evidence="1" type="ORF">BQ5605_C011G06628</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NSG0"/>
    <dbReference type="STRING" id="796604.A0A2X0NSG0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY12857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="155" mass="17252" checksum="0DEABFDBD905E1AB" modified="2018-09-12" version="1">MFFNRIRSNAFPLFQVIACTNRRCIIHADFCGDLSTNMRLLAAADRMTETEQAKAQDFANWLLGVGDGSANKTEDSIALPRELLLPATTTNSSGREVEYFRERAKLAPKNLQVDHINDMVLDLLPGDAQTFYSADSSQHYRDGVAPHSTRVSTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NTL6</accession>
    <name>A0A2X0NTL6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C011g06639 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C011g06639</name>
        <name evidence="3" type="ORF">BQ5605_C011G06639</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NTL6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="2">
        <location>
            <begin position="281"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY12880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="430" mass="48516" checksum="E5F9049A9E1D9829" modified="2018-09-12" version="1">MADPTLSSPHHHLFLRRGQRQMAVCAHCKARHWECKGRTGHFSMCCLQGKVQLSPLSGPIPSINSYLKARIAICLIDPAEATDTRLGLDGADSRIQRSTLNKLESMLRTKNHFVREGSCASAYHLVETDAPTTFLRRARKWRCLSAIPTPTREIVDVKTLFSRCTVIDVPRVGPSTKSLARSIRLRCLSVTHYYFLQGKMASTPTFLFAGFAKLGCQSPETESRSTMGSNHGRYLPVSVLLTKAKRRTKTATMRMKTAGDEENGDGERTRLRDDHQGDEEYLAYYLHERGDYFSIPHATQRLLLEFVTDGYSQVETDRLNYIRFRQENLRLTTAQGITDAVANGLTPDQIGRSRYQDAMACIVKYGKPSLFITVTCNTEWPEIKAALEPNDEAYNRPDLIARMLKAKSGNKQRPGCFGDEWILFLCCTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NU74</accession>
    <name>A0A2X0NU74_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein transport protein sec16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C019g09018</name>
        <name evidence="11" type="ORF">BQ5605_C019G09018</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6 7">Involved in the initiation of assembly of the COPII coat required for the formation of transport vesicles from the endoplasmic reticulum (ER) and the selection of cargo molecules. Also involved in autophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SEC16 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY24175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0NU74"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09233">
        <property type="entry name" value="ACE1-Sec16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024340">
        <property type="entry name" value="Sec16_CCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024298">
        <property type="entry name" value="Sec16_Sec23-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402">
        <property type="entry name" value="RGPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402:SF6">
        <property type="entry name" value="SECRETORY 16, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12932">
        <property type="entry name" value="Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12931">
        <property type="entry name" value="TPR_Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec16 central conserved" evidence="10">
        <location>
            <begin position="1465"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="domain" description="Sec16 Sec23-binding" evidence="9">
        <location>
            <begin position="1657"/>
            <end position="1998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="150"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="841"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1377"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2049"/>
            <end position="2073"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2203"/>
            <end position="2313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2329"/>
            <end position="2416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="100"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="165"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="475"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="528"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="546"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="593"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="633"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="740"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="756"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="783"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="842"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="866"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="911"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1000"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1049"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1138"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1194"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1232"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1251"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1389"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1416"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1426"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="2056"/>
            <end position="2073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="2348"/>
            <end position="2360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="2376"/>
            <end position="2396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY24175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2416" mass="256398" checksum="FF571F37B4A805CD" modified="2018-09-12" version="1">MSGYGGGPPPRGTAQQQQQHQHQQYAHQQQQQQQQYHQQPPQQHGRGLASVGSASALFGDQQHQDDDLFNVQQHQHQQPYGQIDTVMEEDEPDSPQMNRYGQAQPAQQSHQQQYPGYDQQQQAGYEEPPFEPAYYPGFIYAAASNSYLPDPQAQAAADESWGQEGQYDQSGHYDQQGQYDQQGQYDQQGQYAYSNEQQPQQQQQHEQQYGDYSHAQSQQGQDPSHQGGGEYDHQPFEPAYYPGFIYDAASNSYLPDPNAQAANETQADEGGWDPSQQEDYSQQDKGHVKGGNSNDATALASAEHQQGLPDSAPSHEETIVWNDESCASAPGTDSAPFANSGDAQQPEDWAQYDQYDESNVFGQDGGANAYEQQGYSYEQTEKQYDSYSPNETSDQPLSATTATDPSHEEQPAASSTQAPSPPPAASQKEPVEPSPPAHAEQEHDAYNQGSYEDEGAQPDNLDTTWGQEQGEYEATSWTHQNAQGPQENSFEPYAQQGQQSWDQGEYDQAGYDESQGQAQASYLEQEDQQQYSDQQYNAYARAPVAAPAPPPATAAAPAPPRQATAPPPPRAQPKPTSDVARAPLSPRQAKPSQRQPEPQAAQRQEQQAPAVDAPYDPYAPVRQQPRKFSPVHAPSAPSTLSSTFSPPPRSSSRGSTRSTSSSVAAAGAPPKRSTQPPSASSTAALSNAAPAPRMSGPPKASAAVAPPPQAAFEAPPRPSSAASNASNLSSVAPPPRSDSRSSSRSTRSNVSSASVQQPMQLSQTRQAPTAAPPGRVLSPPPQASAAAAPPRSQAITPASATRHAGAPPLNNSAALPRGAPRAAIAPTTQFQSFVAPLDAYEPQPVASAPAPAYQPPQPRKEPPKSQPHQQQATLPQAAQAPPPKQTAAPPSSAPPAPKKNAVAGGYEPFDPALAAQRKAAAKPVASRLPPPVQPRRAPHQRGASAFAGDSPYATLPEDLPPMPGLSASESINEEEEEPAQIDAYRPPPTQASSRKAPPLASRAQQTPQQRPAPPSQSQGQDSQGEAVPSWMDRREPQPEQPSAQQYDNSQSWETSSVSSQISSASRATAPGGPPRAQQAQAPHASSTKPPIRGARKNTPPSAPPPTSTAPPDDGVRRMPKVPPVPAAAKPAPAQSRPGQPPMSKVPPQPSARPARAQQTTRPPGSTGAAPPRGPPSQLTAARPQPGPAALKPATATQGHPPLTNNRETAAEPHAVPAFNFEAPSPEIRPQADQDDMYAPEPLEEDDDEGTERDQSVIEHPPGAHDDSFAYSQRQEYGYDSQQVQYGAGNNSYQPSHPDNQAMEDAQVYGTGGMSTSTSGSNYGDWNGTSEAQSGYDYVSNGIDSLCEFDPTVLPGHLPGQGLICELFDSPALADPYNPKQMYEYPQAPSRDSNYTPQMARTTSNYASPVKPAPAPQGNNLSYQPKQAQGAPYNPYAAQQQPQQGYAPQAEFNGPPADLQLDRSTAPVISWGLGGKLVTAFPSSSQASFGYGAPTSSGEVQVRKLAEVLASPESITPFPGPMFLDGGKANSGKKRKEAVAWLEARTTELEKEVSYLQGVGPGAFGADVEGNKRKLEVRLILFKLVKVLVENEGKLFGTPKIEEAVRSILVPLSEGSDLSDTDLPTASQLAAAAAPLTPATTGSIANYTVTESNLDKLSTFLLRGERRKAVQYALNQRLWAHAFVISSCVDTDCWKEVVLAFLQSELTPSIENSTGGATGREAMRVSYAMFAGLEAESIQQFVPPVSLAPSMLSPKLLPSTLPTQFSPTTSLARRSSNAAEDVLNRNLPESVLATWQETCAMIVANRALGDSAALTALGDALAANEWTDAAHVCYLLSPATSPIGGPGSPGARFALLGASTSASNGTNPVDIESIQLTELIEFAFSLPPAVKGQEPFVGFPHLQAYRLEHAARLADNGQIAQAQKYTDAIIATLKLATKPSPYYTPRLAGEVKAVADRLHAVAGQDKSGSWLGRMVPKGPTKEGLWSTLEGGFTKFVAGDGETSQASLAAKAEVAKAANGAPLGPFSHYSSIAPDSNTGTLSRIASSADLTVAPPSRPHSSAALVPPSVPVSSVNNHHQLLPGPPPVKRAPFKTHHSRSSSLGVAGYNYDPNAPPPWQVAIAARQAPPAPVPDATPRASAQEFTRTPQNAYGYGSASFDDPPPNDGGLRAPAFAQVDQGAFSEDESGFISPMAAYTPAVSPALAGTRAYNPTPQSHRRTTTQDELDDLGISNNKSKKPGFDSIGEGEEEEMGVGPGQVQNEDGNGPVEESTGAQKAERPSIRTAPSRSWLGGWFKRDSPSPVQNGPGPVRANLGEQTSFVYDAELKRWVNRKAGESGASTPITTVPPPRASTASPSRSSRARYNTETPPPMPAMAPSRNDTSSAPPPSLNRSQTTSDLRGSAASGAGRKKPNRYIPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NVQ4</accession>
    <name>A0A2X0NVQ4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">RING-type E3 ubiquitin transferase (cysteine targeting)</fullName>
            <ecNumber evidence="17">2.3.2.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Peroxin-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">BQ5605_C013g07308</name>
        <name evidence="20" type="ORF">BQ5605_C013G07308</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-S-ubiquitinyl-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.36" evidence="17"/>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NVQ4"/>
    <dbReference type="STRING" id="796604.A0A2X0NVQ4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48178">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48178:SF1">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pex N-terminal" evidence="19">
        <location>
            <begin position="54"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="380"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="486"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="337"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="489"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="SGY15270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="534" mass="59662" checksum="79AA269D39EC1249" modified="2018-09-12" version="1">MTSSSDPPPASTSFWKPSTDPTPRLQAIERRLGSEPAPRLRISRVAQLDADLLDHELESILAAPMGKALQGLRVGLALSYEGRCLPGGASWEPELMALLRIAVLKMSIYDRGITYGSGLQNLKYRNERGRATNQSSAAVDVDLTRFQKLSYMALLVLPSYLHSCLRDRMLLSSWPDEPLPSSWFSFFNPIRLLNVLVRPSKDSSLRWRMEFKRVCWELLNLVERCTAVATLANFLIFLYDGRYRTLVDRILGMRLIYAQRSIKPNVSFEFLNRQLVWEAFTEFLLFLMPLISVRRLRTRLVRTLSNWTLRSKLLSMLISNLPQTILRTLKIDTQLNPNSHHQLSKNGTRTKGKPTRPQGPYAFLPSTTCPICYSNQNAPPTRLPTNPTHLEPGRSGGPSFTLGSYSNLGASTNPSGSSASLINADVGVKVPYVANCGWGCRYCYYCVVDKLVGAQEEGEEGWGCWRCGGVVTEVWREIGGPKAVVEGEAEGKGVEGDESEKKLVVGDGESVLDEKDSIETQSVGSEHNRWRDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NVX1</accession>
    <name>A0A2X0NVX1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C015g07725 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C015g07725</name>
        <name evidence="25" type="ORF">BQ5605_C015G07725</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NVX1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="472"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="751"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="263"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGY17259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1158" mass="129533" checksum="2FFC65404E1E7075" modified="2018-09-12" version="1">MHLLKESGEIKIAKLCKDNYELWSIRVEAYLESKGYASVLEHGHVRPSNVSLVEWRTMHGLNASVTDTQVVVNLQKKDRRTRALITQCIDDANLKMVKSKTLSAKDIWDKLCQHHEGNVKPFKIRTLLMELSNAKYDEDENMGESLKSMIDKADQLEDLGQKFGDKAMIAYILQALPPSYEMLKQAIRLGEIRSVDHVINCLTDEYTERKLSGKFDKLLKNAGALAVQSTQASRDPNCVCRGCKGKGHFAMDPECPKYDAKKNHGCARNRNKKKKQDSKESADSNELAKFALTVKVSQVNQGEIWILDTGASQDYVGDASLLSNRQSGNLKVQTASGQVVHCDTYGMVRFKLKSGASLSLANVYHLPGAPVNLILTRALFKSGAKCGWEDGNDVMTITYQGVILAKTLSGTSYALDFTRIVEDQAHVATRATVGAPLMEWHRRYGHVPVSSIMELVKSGAVEGLVLTDEKVHDCEPCISSKSRASKFSELATQVTDVLQRVFMDIGFVAEDQVDFQGRKAYLAIVDQYSTAKWTFPLKTKSAEEVTRVWIAFRQGTGTEFTNKLIGADFQSQGILHETSAPYTPQQNGTVERFNGSLMAIVRAVLAASKLSWKYWSYALAYATFVANRILRAKLEGKTAYEVFYGKKPKVSHFRPFGSTVYAQVPKSKQSKLESTSVKGIFIGYDSEYNYRVLVDPNSDHKVIVTRDISVLEHKSEQVGVPEVTTLPVGPDEEKGPVDNDDVVVDELQDQVDGEQMPPARQNRPRWEYGDPAVKGRNPGRYEEIDANNKIPHRTRSQLPSNYEEAMASPEADKWIAAIKAELDAMARHQVLIDSDLPSGARALRSKWVFTRKENAQGKVTCYKARLVAQGFAQRPGIDYNEMFAPVARPSTILSLVGTATAQGLFLKQFDFDSAFLNGTMTEMVYMKYPKGWDRPQTGQALRLVKSMYGTKQAPQEWNAAVNSLMVERGYKRSDADSCLYVKRVDEKFIYITLYVDDGMVASNDQEFLDAEIEAFNKVYKLKRLGPVKLFLGLEFERTSDYIFVHQSKYIRDLVAMYGGGSVSKHPVKVLMEPRSDVEHSTDPFDDVALYQSAVGVLQYAAHRARPDIVTSVRAAASKVSAPTQADWIAVKRIIRYLQGIVDWGLKFNHGGSTRDLWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P071</accession>
    <name>A0A2X0P071_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BQ5605_C019g09023 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C019g09023</name>
        <name evidence="12" type="ORF">BQ5605_C019G09023</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY24239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P071"/>
    <dbReference type="STRING" id="796604.A0A2X0P071"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001289">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="496"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="524"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="325"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="558"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="580"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY24239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="591" mass="62196" checksum="78D7C470ECF34B0B" modified="2018-09-12" version="1">MASVATSCPTTSNGTNRMHDVDQQQPPDLARPPIPSSGTPSVATNSAPAPEPGVMTTAASTSTTSRLPRLPSISSLLAGFPGHDAFDQSQTSRRTSAPRIDEHPMSSYKMGGGPQQSQSPSRGFSGWDQPSPFSQSLPTGSSGTAPPLFPRPPIPTKSATHPSSGQLTSPTGGPLHPLPSGLVGFAPLSPPQVDRGLVFRPRSNSLSVHPYANPYHHRSATYEHDPRRRGSLNEGIARTTTSGTWSPTTVPGGPFGQSAGAAAAAAARARKHSVDSGWTHCQMSSLGTNASPRSRAASISAAPEDHRYLPNWADHERDMAMRQARNASGRVNSLASSGSSPHASSEPDGRQEAMEHLELARERPLTGLSSREPVGAILASSSSPDARLALGERPHGRLSFGGAPDVTGLHITSLDGRRPSIPMINPFNGGPVGHGLPSSASHPSVMAGHLPDHQNQAWSRTSPSLPGTGSFPSQPHLALGVSLDDGTNESGEHGRYSCEHCPKRFARPSSLRTHIHSHTGEKPFTCETCGRGFSVQSNLRRHFKIHRATRLANSIVGEDGDVKIRGSDDEGQGSVSPSDEGSDELEQTQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P0X1</accession>
    <name>A0A2X0P0X1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C051g12556 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">BQ5605_C085g13007 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C085g13007</name>
        <name evidence="5" type="synonym">BQ5605_C051g12556</name>
        <name evidence="5" type="ORF">BQ5605_C051G12556</name>
        <name evidence="4" type="ORF">BQ5605_C085G13007</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000040">
        <property type="protein sequence ID" value="SGY28735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000096">
        <property type="protein sequence ID" value="SGZ29610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="349"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="630"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="685"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="722"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY28735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGZ29610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1530" mass="168990" checksum="7A6FFEF3BD53540F" modified="2018-09-12" version="1">MSDAGASAPEAKLREPKPDAPPLRPPTHSAAFATTELLRNSSGYRDWVLAIRSRLPSGVVRYLNTGVPLESWPASYVPLWDHYACSSICASVDSQTVLPGLSPYLDESLAAPKVWQALRERYGTVSAVDLLPVIQRLFSSDPVPVTPDLFLQFRDSFENDARLLQDSQVTVNALLASHLLARLPSSFDAWRTTFVADQGDSTAMPSATEIFTRLYRDVKARPVDTPVAAVATPQARHGCSRPCPNPSCRKLHWLRECPDTAWAAAYRARRTAEKKASQPVASPTPCTPKALLAVPANVSLLTLHRRLAHLPVAQIKNIVQSGLVTGVDWVYKDQELRDFYCNACLASKAHALPFARSKSIASGRLDLLHVDVAQMPRPTFGGHRYMLVIIDDFSRKHWCILLALKSDIFPRLRDWILEVKNATGNKVKTIRSDNGGEFTLRNFVDFCASKGIRRELTIPYTPQQNGRVERSNRTIKEGILALLYSSGADSRLWGEAALYYVHCKNLMPHAGIGGEIPDTRWHGFAPDISTLRAFGCRAWHHLPSAKRTDLDPKAVPLLFVGFDQHAKAFRLFEPSTRRIQLSRNVVFRESEFPALRPATDVRAEPIPLPVTVDAYPDQVDPLEPSLVASPRSLAPRAEPPRPVPAAPDQGPHRPAPAREVPDQDSLAPPAPDQGSPARELPDPESPASSASDRGSSDSAISTPCPSPRPVASRALPAPPSPARSDSPDPIDLLPRPRDVASLCQAQEFPDDVDDALHSPSAVAYLASGAAALIETSPADPAELIAPARDPPHWRAAMATPQADDWRLAARDEFDSLLRDFSAFTPIDESLVPADAKVLGSRFVFRTKRDQHGQVKSYKGRLVARGDSQRSGIDFDETFAPVAKFTSIRALLALAAAHGYHVHQADIDKAYLHGKLDAPLYIRVPDGIYMPGKVLQLHRSLYGLRQAGRIWNDKIDSALSALGYVATESDHCVYVRTTGDVHHYIALYVDDLLMISPSLPEIERTLQGLEQRYGVKRLGEAEYVLGIQIRRSPDGSISLSQEQYLKDVLARFGMSDAHPVATPMQPDLRLEVELQPTPFPDRTRYLQAIGSLMYASTGTRPDLAYTVGYLARFSHSPSAAAWGAVKHAFRYLAGTLSHGLRYARGNPAPLLGYSDCNWGACVLSSKSTMGYTFVYAGAAVSWSSRLQSRVADSTCDTEYLALSHAGKEAIFLRQLFGELGLSSSKPVLIYGDNQGANALTKNPVFHARTRHIRLREHFVRDMVSMGDIVVQYINTGEMTADIFTKALSCDLFARHRGRLEWTFHTDHCIYSHIDDQQRPHYIALYVDDLLIVSPVLNEIKHVISGLEQRYGVKQLGPAEYILGIQIRCLLYLALSHAGKEAIYLTQLLSELHVSPIAAAHIFTNNEAAAAVAHDPVRTSGTQHIRLREHFVRDMVNRGDISLSHVGTANMVADLFTKALGPKIFGTHCYALGLRTRHPRFKPTSRLRGGGGVRNPLSAQRAERHEIALEPHWFRVQTERIKRCNSQAKKDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P210</accession>
    <name>A0A2X0P210_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g04177 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g04177</name>
        <name evidence="2" type="ORF">BQ5605_C006G04177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY56829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P210"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY56829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="75" mass="8427" checksum="EA95B93781635042" modified="2018-09-12" version="1">MSRARGGDGMRDEEQEGERWRLSLNRTHRMSRKAAERRGVKPEAEGHVPGCFDGKWVLGERGRNGLSPRGLSPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P3G3</accession>
    <name>A0A2X0P3G3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g02150 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C003g02150</name>
        <name evidence="1" type="ORF">BQ5605_C003G02150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P3G3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY39124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="52" mass="5495" checksum="4DEABF4239974961" modified="2018-09-12" version="1">MSRKAAEHCGVKPEAEGHVPSCFDGKWNLDDVGTSANVDGTVCRPRGLSPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P4N5</accession>
    <name>A0A2X0P4N5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C001g00015 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C001g00015</name>
        <name evidence="1" type="ORF">BQ5605_C001G00015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY43338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P4N5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY43338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="144" mass="15703" checksum="46290C13F50FAEEB" modified="2018-09-12" version="1">MSPATYSSSAPYPWPSVAPRGPGTGLFPELECAKECERTKSTGHFGTCCSRASYLKARIASYNNALCFTSLAAHFDQARLGGHSRTPLFCVHGSSTRPRPPTLDLGLDGADSRIQRSTLTKLEFMLRTDNRFVREFASVKARAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P6C0</accession>
    <name>A0A2X0P6C0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C001g00625 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C001g00625</name>
        <name evidence="1" type="ORF">BQ5605_C001G00625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY48192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P6C0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY48192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="55" mass="6125" checksum="AECC35B4F071BD70" modified="2018-09-12" version="1">MSHTIEGSMAFRPVYGQVAERRLTLGCQRLFLTAGAPPHKIDRILKVSSLARSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P806</accession>
    <name>A0A2X0P806_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Chromatin-remodeling ATPase INO80</fullName>
            <ecNumber evidence="15">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">BQ5605_C008g05214</name>
        <name evidence="20" type="ORF">BQ5605_C008G05214</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="15">ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the INO80 chromatin-remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The DBINO region is involved in binding to DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="15"/>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0P806"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18002">
        <property type="entry name" value="DEXQc_INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000022">
        <property type="entry name" value="Blast:Putative DNA helicase Ino80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020838">
        <property type="entry name" value="DBINO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031047">
        <property type="entry name" value="DEXQc_INO80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050520">
        <property type="entry name" value="INO80/SWR1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF2">
        <property type="entry name" value="CHROMATIN-REMODELING ATPASE INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685">
        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13892">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51413">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="DBINO" evidence="19">
        <location>
            <begin position="413"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="670"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="1247"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="25"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="221"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="300"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="482"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1433"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1500"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="326"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1433"/>
            <end position="1452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="SGY79746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1540" mass="172868" checksum="CE913E6B43BCE748" modified="2018-09-12" version="1">MSLSRLLNNNPSGSSSVAMNGVSAHAPAAVASGSASTESTTRKRSRASRASVSFHDDLDGDEEGSSARRSSRRSIQPKRYIDDIYADIEDVADTSFDLNSSRNGAEAVAPPEADEDSDSDSETLLRATAHIWREPLQAYLDRIHAERQQLEQDWIANEASRHFATAARIASFTERRIDEMRARKEAKLLEREQELQAAARLAEQERQRIEFEAERNAIKEREKEDRLRKQREAAKRKRDEDREKKGKAEEARKIRSEKDREARRLEFERWEALTPEQRAEEEKLYGERFKFDRDEMLNRFDLDQYGKGARKKKRLENDDPSGLGYEDGDLEEDVDELAEGAHGSSRGANGASSHDMLRQSSSHLMHSPTSSRAGSNAPGYASDDVDHESARDLNSSPVKAKKTRSAEELERKLWIHIAKRDIPKVSKIQQQSSQSRQFFAKRVGSIVAREARRAATRTKTVKDVQVRAKRVVREMMLFMKGNEKRERESRKKAEKEALDKAKKEEEMREAKRQARKLNFLITQTELYSHFIGNKIKTSEAEESEDTASDAKIAAPAESNPSVIAALAKPAASNGALKDLNFDVDDEANVAEHARRGAQAAVDAAKNAASAFDAAAGQAKPANGAEGLSFDDSDDLNFQNPTMTGAAIVTQPRILTCTLKEYQLKGLNWLANLYEQGINGILADEMGLGKTVQSISLMAYLAEVHDIWGPFLVIAPASTLHNWQQEITRFVPALKALPYWGNTKDRAILRKFWNRKSLRYDKDAPFHILVTSYQLVVQDEKYFQGVKWQYMVLDEAQAIKSSSSTRWKTLLSFKCRNRLLLTGTPIQNSMHELWALLHFIMPSLFDSHDEFSEWFSKDIEGNAENKGAMNEHQLRRLHMILKPFMLRRIKKNVQNELGDKIEIDVYCDLTPRQKAMYRTLREHISITDLVSRATSLNDDDSVKRLMNLIMQFRKVCNHPELFERADVTAPFAFANFPVTSNLVRDPEMLEVAYATRSVIEYAIPKLLYRDGGLLNVPGQNSRAGSDSLHLDRLLNIWSPDYIQHSLRQGESTFAFAQSLGFSPSELSKVALAHDVIRIGLALENEATKSVRGDYDAISLEGEAPAPFSLVIPNKTASLLSNISWREGGLVPLAEVEQEHRVHSRLAKPDARFYMDKVVAPSIDAVCSDRSFAYDQERQRFDPLFSAAIYGLPGSSQNTRTDIQRFESALPGLPAQGVLGASSPAQLPFPPMQVPQLHKLILDSGKLAKLDSLLAELKTGDHRVLLYFQMTRMIDLMEEYLAFRQYKYLRLDGSSTISERRDMVMDWQTKPELFIFLLSTRAGGLGINLTAADTVIFYDSDWNPSNDAQAMDRAHRLGQTKQVTVYRLITKDTVDERIVQLARNKKLVQDAVVQSSSGLGPTDSGAKTNEVVSLLLDDQELEESIRNAEIKRKKAEEKAKEDGHRGVRMREEAKRQKKAAALAAANKPSRWEAEDDEEDAFGFFAANKAVVADDEDGMTSMVATLGESGADSVNSTKTKGKGGRKSTGEAGASKAKRRASKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P848</accession>
    <name>A0A2X0P848_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g04001 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g04001</name>
        <name evidence="2" type="ORF">BQ5605_C006G04001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY55311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P848"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY55311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="52" mass="5738" checksum="A3BFC54EEB81347B" modified="2018-09-12" version="1">MSRKAAERRGVKPEAEGHVPGCFDGKWNLDERRNLGERGRNGLSPCGFSPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P898</accession>
    <name>A0A2X0P898_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g04072 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g04072</name>
        <name evidence="1" type="ORF">BQ5605_C006G04072</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY55759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P898"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY55759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="128" mass="14533" checksum="58DCF6B6C9448116" modified="2018-09-12" version="1">MLRRSVDLLHHQLQPTDIQKLGSQSSQLSSRPPSLCITNLEEVRTLFRLDQSLAVFPRGLGFHRLRYLFNNSYTTNVVLRLAATRTTIPLRLARSGKALPDTTIREVRPEPATSLHLAGRWMYSAPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P8S3</accession>
    <name>A0A2X0P8S3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C009g05555 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C009g05555</name>
        <name evidence="10" type="ORF">BQ5605_C009G05555</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the V-ATPase e1/e2 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY82249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P8S3"/>
    <dbReference type="STRING" id="796604.A0A2X0P8S3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008389">
        <property type="entry name" value="ATPase_V0-cplx_e1/e2_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05493">
        <property type="entry name" value="ATP_synt_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY82249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="81" mass="8901" checksum="CC814316A303A746" modified="2018-09-12" version="1">MGGWLIIWVGLILAGLAAGGFISVPKGENQVVIRTSILLVVTCCYLMQVHTPSSAWAITYLAQLNPLIRPRRSDLRLQHSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PBP7</accession>
    <name>A0A2X0PBP7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C032g11073 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C032g11073</name>
        <name evidence="2" type="ORF">BQ5605_C032G11073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000067">
        <property type="protein sequence ID" value="SGZ04589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PBP7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ04589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="101" mass="11597" checksum="868DB7D19D995095" modified="2018-09-12" version="1">MPVQTPTLVKGTPRRSPSIEFRESALRSASRAKPTTSRDHHSTNTTPELPTRRSRAAHWRSQLTQKDHVDPNELRKKLGLLLVDKFGEDLRRRSKCGRCVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PCC9</accession>
    <name>A0A2X0PCC9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit L</fullName>
            <shortName evidence="4">eIF3l</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C005g03247</name>
        <name evidence="7" type="ORF">BQ5605_C005G03247</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit L family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY72999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PCC9"/>
    <dbReference type="STRING" id="796604.A0A2X0PCC9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03011">
        <property type="entry name" value="eIF3l"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019382">
        <property type="entry name" value="eIF3l"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10255">
        <property type="entry name" value="Paf67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="353"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="585"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="591"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="603"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY72999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="627" mass="69993" checksum="18F02F5B6A6EB6F8" modified="2018-09-12" version="1">MAQPYTGEEEEELYDDGAPDFGIQRADYDGNYNEAEAEQYAQQQRVAEAAAHQAQQAEALAAVPEPVKNYIMHLFNLVTASSPSLPEIQAAYEQGWARLTDKFFAKTEWPEAETIAPLVNHGPSACFCRSILFLHLTPSSLPTDEVFLTLYRELYFRHVYARLQPDIDDRIASYENYCQLFNLILNSPGPVPLSLPIDWLYNIIDEFVYQYTSFALWRNKVTGKTDEEKQILAESSQVWSCYSVLNVLYSLIQKSKIQDQLAAQAEGIEDVEAIAGEFGSIRLYYHLGYFSILGLLRVHVLLGDYTLALQMLDGIDLNKKALFTRVTAAHVATYYYVGFSYLMLGRYPDAIRALSHILFFVLRLKHFQRGSQFDQINKTADRMYALLAICQALCPTKVDEGISTAMKDKFGDQHAKMARGGAESLPAFQEMFSLGAPRFISPNPPPYELESNDALTTYAALPDASAHQTTIFLGSVESQLSTSTLRSFLRLYTTLGTDKLAKFLEVEEDEVLEMLMVAKGAARKLTWTEGSLLQGEVFGVSDINFGIDEGHLTVAQSTTSRRYGDFFLRHGLKFSDVYENLKNKPLPIPKNHNGNNAGASAAKPSQTNSEAPKSSTTGSKGVAWAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PCD0</accession>
    <name>A0A2X0PCD0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C030g10830 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C030g10830</name>
        <name evidence="1" type="ORF">BQ5605_C030G10830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000069">
        <property type="protein sequence ID" value="SGZ08980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PCD0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ08980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="50" mass="5527" checksum="A6B0380F31E45618" modified="2018-09-12" version="1">MQKTFRALGFVPSSKSTRRLMVLMHDASTVRGCLTTYKNSPISSLANPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PCL2</accession>
    <name>A0A2X0PCL2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C005g03458 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C005g03458</name>
        <name evidence="3" type="ORF">BQ5605_C005G03458</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY75921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PCL2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018828">
        <property type="entry name" value="RRG7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28133">
        <property type="entry name" value="REQUIRED FOR RESPIRATORY GROWTH PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28133:SF1">
        <property type="entry name" value="REQUIRED FOR RESPIRATORY GROWTH PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10356">
        <property type="entry name" value="RRG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY75921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="225" mass="24765" checksum="59C01D004FBE9FDA" modified="2018-09-12" version="1">MSRLRPSSLPSRIPSSTLPRISTVALGTAYELATLQFLSQPPLSLQSLLRIGGANDKGIDLRGFHIPQRSVDDDDDDDLVHEGSVQPRRLRPKRYPILVQCKAVSKPLQPSVVREFEGVLSTEPGGLGILVGMNGFTESAIKRALASELPMALLRLGKGVLGRDFWAPVEGEVVGKEEKTWDFGVNKAMRELVGEDARGWLIGGVRRKWGKEDEETDEVEVEKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PIJ9</accession>
    <name>A0A2X0PIJ9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C045g12227 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C045g12227</name>
        <name evidence="2" type="ORF">BQ5605_C045G12227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000115">
        <property type="protein sequence ID" value="SGZ31666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PIJ9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ31666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="800" mass="90304" checksum="6872DB95D6E9EF30" modified="2018-09-12" version="1">MYVPDERVIQPWREDNGWCASPGFTKQTRASNQITDSAFLLILIHNTPTIIAVDGNFQHRQFARATADPLKSRPALFLSPDKIRNEQALIDGSTEAGEQVPWCCWCRDECTANWKAADGGVTSASSNVVADTGLVAAVCRHDHCLRLCNLHQSGEKSVYPVSLLKWILKEVEVGETDCTTGPARTSDATNVGSSSGSGSHQSSSQDRSRVGVAYDIACNLSSHLRRQLISPRYAQRNLLADHLPRLEFALSSMHAYAHKWSCQIDFDPRFLPNFGLTDGEGTECLWSQLRGMIPMNRSSSSSHRLKNINRRASAYNKQHLAELGSLKLTKLNSRLKNAIKLKAEADRVIAEVVNRSEWTVATLLEQWHAQRAASKQISLKEQRKEVAEMRDVMFKLELINRDIAAGWEDLACVNTIDKNKLIEQSTKLQQLVKQRQVLDDRLNSLRTSDINISVLDPGTSLPSSILTLWCDPRCPRLNISIPLIGTDYEPACTLMVASRSLWDLVVQYRQGAERLRLPRLGGKALGRKSMQCLLIGTKAAGLLVKNLNSLRPRLMKAVAMYNDEVKKYAAILANSQDSHSILRTRRVPPSAPEDLNELLKLDILAPLWNNILYSHPTEPWAYDEDVRVGIPAEVRRIGRWPISRRKRFQQVRKQLPQLDEQDDSAMMLLEQVEEERLRTIARRWFLKGGLDHLWECTRQTGKPQMEEWVELRMWCTDDTDVFQRTTTGGLPDHTWPDCINDGMVGESDDITTDHDTLLDISDHSSDDLSHHSVDTIDYGAFSDEIIENSDEDDGDIFWGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PJN0</accession>
    <name>A0A2X0PJN0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C060g12728 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C060g12728</name>
        <name evidence="1" type="ORF">BQ5605_C060G12728</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000136">
        <property type="protein sequence ID" value="SGZ35425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PJN0"/>
    <dbReference type="STRING" id="796604.A0A2X0PJN0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ35425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="66" mass="7613" checksum="81243F2B4EB92DA6" modified="2018-09-12" version="1">MVRSFALVKIYGMAREGRSLVSGQYPRVKARLVSLYWIAFLSAPTAQQPALEIQPREDIRRYRGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PJW4</accession>
    <name>A0A2X0PJW4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C021g09276 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C021g09276</name>
        <name evidence="2" type="ORF">BQ5605_C021G09276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000083">
        <property type="protein sequence ID" value="SGZ20442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PJW4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.20">
        <property type="entry name" value="Centromere DNA-binding protein complex CBF3 subunit, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038279">
        <property type="entry name" value="Ndc10_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031872">
        <property type="entry name" value="NDC10_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16787">
        <property type="entry name" value="NDC10_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ndc10" evidence="1">
        <location>
            <begin position="108"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ20442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="243" mass="27499" checksum="B07CED68D6C85467" modified="2018-09-12" version="1">MRALERPDHPPIKTLYIVADSGKTNKEGRLDYKPVARHFDPCICNVGAVAFYMWFHVRNTGIENGTTSPFSQAHLAETHSCIQSPTRVNRHSWCLIGGRSWQLARLAEIDVLDDLQRLIFPWVREAALAEFEERFEADELCQDKALVGHLKLIQRFKLVILQNAAFLIQTYPDAPIYQTSLFQSDRFRTWAPHLVASVEGNGREEAAPKVVYGGLLDSIVDSLGAQQSSERRSATAHLRSDNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PNL2</accession>
    <name>A0A2X0PNL2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C027g10443 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C027g10443</name>
        <name evidence="3" type="ORF">BQ5605_C027G10443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0PNL2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1264"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="652"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2208"/>
            <end position="2234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="560"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ28766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2417" mass="270771" checksum="DBFB111E74AA14FF" modified="2018-09-12" version="1">MSTGDPGSPPPAPPPPVSATSVQPPRDQIPISSKKTQVTGPATAAPNYAAAASQATQSPEQQQQQQQRAKALGSLLQAMGAVPGNRMDRWVQAIYFAELYPVATATSLKFSALNANRSVENIFYYALEVTLSHQSASRASHADKTDLVACVTRLLSPISPICFEPGVPLPDHLAAYRPQILGVQHSSILRNGAAHHRVTVGFVTGEARDAALTTPPALTWRSAKARFAKSHRFHHNMVELRINVGVQGMLSMDAIIKSFQLLVQDLSGKGHSCQLVQVLRIISVDNASAFAHVAGDYSAFLHFDDDSLFKRPNTTLKEILPSRIGLPTQGIPVTALRHDYEKEAACGRCHFVGHVGTCGLDQESKRKEAHNGNGNANTNANKNTITNDTNIVEAEAPIPVPVVNRIASQNRFAGLEVEEGQEEAVTGQSGQGPEESGEEDAGDKADDEDLEDSEMESEATAKTEVIKLKSEDESVLEDCGGSDGEVIDEDEVMADRRGETEGKVATEMEEREVATEMEEEEVATEVDNVDEAGGATKAENAEATDLGETNRLDNDDDSDATATAATASRESTPHEPTPPLSPETLAKSLREGEEWDRIRANWVEQARLERDQSIERRLDAETPLVRHNFATWDEDGEIRSINIRGTAAKFKKPVMKRSQTAADLSDPSDEPTDAKRVIIKGKSRVVVKDGTEGRRVTRSMSAAAAMPVGVTKVDRGKAKGVAEEKRWSDHEPEDDRFDLNYPLMIKHTIITWNVRRGMGVPEKRRDIYNYLSLFKASAILIQEHFIRPHLWQLIKDEYEGKLFINQHCLTLIPADSPLIDAELLRTHSALDGRLLVTSFRLRGDIKILEINNVYAPVDPKQRAKFFDKLLFHKTQKSHLRLLGGDLNDCPRPEVDRRNQSRRGHHWPILIGKLDSAYTDCIRYKHPITPSFTRPNPNRKRPNSFSRLDYFLLQRTHQKRLDQASTIYDYPKELSDHRPVLIVLALSDDPDATLPQLSLPTTSNQLHRINTTTFKTVEFQRMMEGWLEGASGEEPVGELEVILKACRDRGGEMARRLHRERTERMEYLVGRVQDTEAIPEWGEAETAEWTRTSEELKRAVEERARLLRIRAHVPEIASEERLSRPVHAKLAARNSDSKITALRLSNGELTHDIDVALDHTQAHFQRLYHIEPRDPDRVDRLRDEFLAPIRAARTCDDPRSDPLFLRRLSESQIDLLQRPITEDEVVAAIGTTHPGRSPGPSGVPYELYQTAPKAWAKVLTKAYNAMIERGSLSPKQGQGLVRLIFKRHKKNADRAELSSYRPITLRECDYKIFTKVYVARLNQILPDLLPPQQHGFVKDRRSADAALHLRLLIEELGARRTEFPAAALLSLDQSSAYDLVEHDWIFAIFDALGAPATFLRVLRMLYSGDSTSARYIINGFLTAPVRLTCGLGQGDPASSSVWDIVFQPFLDALHRRNIALNLSIPALHPYPQSRAITSLAFADDVVVAVAGLGSLNLLDDLALDWRHATNGRLNTDKTVVLPIGRRWDPGQRPLVVKAAGESLEWIGLPFDPSGDTELAYANLIERLEATLEGVQHRWLTHHTRAFYVNRYAIPKILHFLAADIPPPEVVKKLDDMLVDFVRGGKGRTSYGRDIVFTAKLKGGLGVIRMQDVVDAVAARIWDVLLGGSGAIWQGLARAALQRAQSDLDLATDLWPHPSTPIPSDLHPRWRAALGVPKQQDAQVNPRTLTTANLLALPTLLGSLHTPIRGRQTIDAVHIPDYLRLQGYPKVADLYRRELYAGGGFHLWTPPADVLGDNSEYDRRGLPQRLAIAAWYRFTVDRHNNTPLAVAVAAGRLNVPPRIGTSAPLEAILPKPVARFAMEQRLPDPVLPQQASQYKLLNMARPYTIRRIRRVLNAKAFTNTLGLKGPPQPDDLRSFWKAVNSKALTAREREVWFKLILRFTPTRKLQHQQQHDTSPACLVCEAPVDDTDHYFFGCVDSRNVWIAARGVLCDALGCDTIEDAQYTTLQRLFGLPKLKAKLSEQEGAGWTIEIFTGMVLEMISSGRWRMQKHGTRMESVERRRVVLEERMKLRAGGARGGRGQGNRNWGQYDEQVLQKKKKTLDADAVAKFAQIADLYWRDEGKGWALVGHRRGFWQHSKEPALRHEHVWARVGQKLKAKALLPKTAVRPARIPLKEDPHPRCFNFFGLTRPFTIRKLRRLVNTVRFPGKDGQDRALPGGQPQEPRVKRFPEGTSQSGRQRFWSWLHDRFASAAEQDTHWRLMYDVTPTRKKQHVQGHASSPSCLFCGNDAAVIETVSHYFFGCAYSASYWSGVLRILFDKLGIEDTDVDPSTFTQEQLTMGLPLLRGRGRTTSKWMWVRLACAIGFQRLHLLRWHVHQRFEKGRVVAPPSIPSALRAFKRDFLSRAGFVPGARDWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PNW7</accession>
    <name>A0A2X0PNW7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BQ5605_C044g12160 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C044g12160</name>
        <name evidence="12" type="ORF">BQ5605_C044G12160</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000114">
        <property type="protein sequence ID" value="SGZ31372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PNW7"/>
    <dbReference type="STRING" id="796604.A0A2X0PNW7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF11">
        <property type="entry name" value="CERAMIDE SYNTHASE LAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="11">
        <location>
            <begin position="145"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGZ31372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="434" mass="50407" checksum="96100D7DA1A3F479" modified="2018-09-12" version="1">MARKRSDSVKEALRQLEPTSYSTERRNGPTGAQHPASAVASPFIRWLVQPTESLKLIALTSGAWAAIEYTRPAKLINPLSPLLFISYPLVPALNEDTPRFDKGPLDLAFVLFYIVVLSFMREATTRFIVRPIARRLGLSSEAKLQRFLEQAYAIVYFSASGSFGLWVMSHQKSWWYNTKHLWLEYPHWRMEGRLKSYYLLQLAYWCQQMLVLILGLEKPRSDFKELVIHHVVTLWLVGWSCEPCLPAFRHTSNRSFVSRSSHADFLNLTMIGTAIFVSMDLPDICLALSKCLNYLNLQRTSECSFVLFLCVWNYMRHYLNIRILFSVWNEFDLIPHEYRSWTAAADHPNGWWLLYGRQTLVLPPWLKYQIFAPIMALQLVNTFWSFLIWRILWRMIAGIPAVDIREDGEGSDDGRQLIDRSATAVSRKTIKKMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PNY2</accession>
    <name>A0A2X0PNY2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C051g12552 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C051g12552</name>
        <name evidence="2" type="ORF">BQ5605_C051G12552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000096">
        <property type="protein sequence ID" value="SGZ29601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PNY2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="25"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ29601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="488" mass="54744" checksum="5C81E0C200644A79" modified="2018-09-12" version="1">MLPSRNADLWQTKAIDEFTSLLNQYKVYVIVDQAALPDSAKLLRSHFVFCTKRDQFSNVKLRKVCLVADGSTQRPGLDFQERYSPIVCFTLIRALVVIAVLRGYKIKQADVNKAYLHGKLDQPLYIQPPQGINLPGKILKLERSIYGLKQAGRIWIKEINSTLRSLGYKPTVSDLCVYTKRHGNDWHYIALYVNDLLLIGPLDDEIEQVLSTLEDMYRIKRLGDAEYVLGIQLKRSNDGSITLSQERYLQDVLEQFDLALAKPASTPMQKNLLLELDQSSPSDQEQTRYLQAIGSLMYAALGTRPNLAYAVSYLARFAKEPGPTHWTAIKHVLRYIRGTFLCALCYMPTPGPLYGYSNSNWGACVRTSKLTMGYAYFLAGATISWCSKRSSHVADSTTNAEYIALSQSSKEAVHLQQLLEELGTHLDLRHSSCSHPGALCAGEMVKKGEIKVEYIATADMVSNILTKALDPKVFVRHRKSLGLQIPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LPI0</accession>
    <name>A0A2X0LPI0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">BQ5605_C011g06583 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C011g06583</name>
        <name evidence="13" type="ORF">BQ5605_C011G06583</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LPI0"/>
    <dbReference type="STRING" id="796604.A0A2X0LPI0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46283">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="521"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="587"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="12">
        <location>
            <begin position="173"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="181"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="111"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="666"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="135"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGY12702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="698" mass="75596" checksum="17BA964FED300B3A" modified="2018-09-12" version="1">MSSSSSSAFLRPPIPSSTSSPSPSQAPQAHHHHPSHHPEDNVDDDDNDDDRMLSSLWQDARTARASARLIDRAKRQQQQQQQQQQQQQQQGEQDHDHDLAVAAASTNTEITYEHSSDAHLPPTTAIAGSPPPPSSTTSPSATSPLVAASSSSSALSTSTSTGSTAPSGRLRGIADMRTKTCWVCYEDSSDTPGRDFVHACECTLVAHTDCLLAWVTTDQLNKSTPAKCPVCATPYVIVQDRSTLLALYKRLRRRWHSLSIVLAGSGLVAGFGFVSAAWGAWAIKKIAGNQVARALLLRHERMPWRYWRTCAAIQAFFFLSSTRDTDTNAPLSLPTVNLPLIPLTLILARTPLIDSLLPFLPLTLVLSNHSSSSSYSLHSSQDPLGLDNLSLTYPPSPTLLLCALPWIRLVYLRLRKKVFKVVLGRRGQDLQGFAGMLMDLQEEVDDMNAPQGAEVLAHHPDHRRRGLGAPRFQVVAEVQLEQNVQPQPEPAGGVVVPPPAGVGGGGAAIIRNRLRLGFGRLTSLVIGALLFPAICSTAGTGLFWLASKGGTQPKSSWIRSLRHILGVQFLLTSPYGSLSTLSRKTNWFSTILFPCFTSTFTPSTSSLLLDPIWLRNAYGGGIVLLLRDVVELVMGWFELKRDQSRRIVGRPFGNGLELNQAPVEVEGGGGGTQGGESTFSGGGRDRATGREARVHNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LQD0</accession>
    <name>A0A2X0LQD0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C010g06060 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C010g06060</name>
        <name evidence="3" type="ORF">BQ5605_C010G06060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LQD0"/>
    <dbReference type="STRING" id="796604.A0A2X0LQD0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490:SF1">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="401"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="486"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="530"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY14097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="991" mass="106866" checksum="554711A4A793822A" modified="2018-09-12" version="1">MYGYVPRGDRHLVIGTDSLARPGSDRLPRTIDDHHGSVEGEARAPVPAAISLSSGCPPRPPSPSSLSPSHPDTTQDRAQAQADDEVLPSPSAPSMAPSPTTASGAYSFSLDRESQRDQQRDHPTHHPHMMHATASSSAHGTGTGNGSTTQRSPDMRRKVELNAPPRLSPNGNQRVRASNSPSASSAETGSDHAAANGGGVADQAIASDSHDVGDFTAVQHTNPSSQDDWAKRTASFEAHSNLKRSSQWDGPGDEAVGPSSHFNHHRERLPSPSGGASSVWAHSPIAVGSTLLYILFSTISTTKLPSAVLDHPEASLTIPLCHFLVLGLLASVHGRVRSDKSPFARPWRKWVMPYVGSIHTDSRRVWTSRVLGLTSSMSLMASMRAVSLLDGRVSAAVEVQIIPFMLMIAVSTPLNSLLPNSTRAGLPNQTLSTIAISTAFLVAFSLIGAPADPIGLSAALIRVPIEATRIVVLREALLDPNHAGEMLIGAASVAFVTTLIPGIVPLIHQLDQLHDVWSPQSTFDFLAFSGWYLLSQLVLLASLAYASSPLYSAIALFPRNFSLLILSTMDRYGVPLRASWSQMAIVLACGTFAVLCADPDTVASYSCLATRATRLIHPVTQSRGKYSHLPSSAADIPMASSPIIPSLSPKKQYPPSSSGSKSISLRAAILPLLPSLYFIIQHPSSGLRLEMACRALPATARGSLCSVPKINGVTSRSVDLVVSYYKEDTQAAKEHIAVMRAVPFVQDRDHKVVVYDKGQNDENTLREALGLLLHDEVIRLPNVGREGATYLQHVLRHYNATVALLDAEINTCAAAQHIAPRDANRVLADHTFFLQPHLAWDWIAKPRIDLVGPDTGFAHFGPLLRTDCGVDGRGRGTYEYVKSFYSIFTGNICPPTGQLSAWSAQFAVSRRRIMANEYARYAHVSSLLEARDGHWIHDLWGANDSGGPSNPAIGHHLERSWPIVFGCTDPMIADQCPDDVHQKDKCQCLDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LQE4</accession>
    <name>A0A2X0LQE4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C010g06070 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C010g06070</name>
        <name evidence="1" type="ORF">BQ5605_C010G06070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LQE4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY14121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="74" mass="7605" checksum="7AE2C8FB396CC7B0" modified="2018-09-12" version="1">MTTSRPLGKDSRAPCLLVTDLDTSSLFPKARGVGVEVPGCFGAVEPDSTIGNPLCLLSEVNPAVVGAAWSVDAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LQK9</accession>
    <name>A0A2X0LQK9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C010g06093 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C010g06093</name>
        <name evidence="3" type="ORF">BQ5605_C010G06093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LQK9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="492"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="518"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY14183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="709" mass="77354" checksum="BC78683053EC84C9" modified="2018-09-12" version="1">MATFNDLLSFVFPSTTFMVDTRAEPEEPPPLTRRGPGEHVPPGLDLISACHDSSLIDRILSGLGRGFDKSGGRDSVLPLLTSSYIKREVSQRGRVINSVGAGLRQLSRMTMGVIDFMTESIAHEPVVMMESETDKEYASHSVPSRKFYVKRSQPGPEDDKVKFSPVVMQGYMASHLKFHYEGSPTVRGVFRPGLGANVLDIRVVTATGELVRLQGARAIAAKVGLIPMRERAERIASALQACSSDKCRFGIIGALPYFVVTELVVIDGEWHLLISDLCSAVVEPEHSTVKSRSLMGVLLGIFMNDFDDYRVEGHSSEVKQRIRDHVKHLDALNVVNEVQSTDDVPPRDSMLDNSPPAQTNTAPSDEAAASTSIRRPDDTSDSSEELEAFVNQGNQTVMARHCPKQAIVCDVKELPDSRMVAIPIELEVDTAPALSPQQPPAKKIRLDSDAHRPKLTEALSLAIQELFSPDAFFSKAEGTFSSPLASTLTSRLNLVRRVGRGASSSVWQAEWLHHSAGSACPSASASTRERSFTTSASSSMPTPSSETTPNTSPQLPLDVMSTPYPPPAPYLPLAMSGRFGPSSKGVGRGRLAAKVVWEEYSPSIAREYFVYTSIVPLLSSQAQEYFSAFHGLYRSGNEGQTYILVMEDAGSPITHKQLEADAELKAKVDFALNLIADEGLHHNDEGARNVLLRPDGRICLIDWGEAQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LR15</accession>
    <name>A0A2X0LR15_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C013g07152 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C013g07152</name>
        <name evidence="1" type="ORF">BQ5605_C013G07152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY14891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LR15"/>
    <dbReference type="STRING" id="796604.A0A2X0LR15"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY14891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="67" mass="7460" checksum="8C65E36FA544A5E1" modified="2018-09-12" version="1">MEILQAKYLFALTKSQREARRRKAVVCKLVDRLGPRVGRGEKKVVVRAGTGWMDLDAFAMGVLAQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LR41</accession>
    <name>A0A2X0LR41_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C013g07182 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C013g07182</name>
        <name evidence="1" type="ORF">BQ5605_C013G07182</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY14962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LR41"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY14962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="47" mass="4841" checksum="90EBFC1F0BCE0AB8" modified="2018-09-12" version="1">MCPASQLSSVSEFAMNRGGSEVAGRPSLIDNAGATTTVSITAISRLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LRX2</accession>
    <name>A0A2X0LRX2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C012g06765 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C012g06765</name>
        <name evidence="1" type="ORF">BQ5605_C012G06765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LRX2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY16118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="54" mass="6442" checksum="FEA07DCA3D92941C" modified="2018-09-12" version="1">METTTFEERVDSDRPQLVVIFTELGDLDVPFIRYIGGSRRTHNLLWIWTWSTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LUZ3</accession>
    <name>A0A2X0LUZ3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C013g07051 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C013g07051</name>
        <name evidence="3" type="ORF">BQ5605_C013G07051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY14718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LUZ3"/>
    <dbReference type="STRING" id="796604.A0A2X0LUZ3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="227"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY14718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1104" mass="123146" checksum="2A8622A955ED8790" modified="2018-09-12" version="1">MMEGWLEGASGEEPVGELEVILKACRDRGGEMARKLHRSGQNGWSIGGRVQDLEAIPEWGEAETAEWTRTSEELKRAIAFEERLSRPVYAKLAARNSDSKITALRLSNGELTHDIDVALGHTQAHFQRLYHIEPRDPDRVDRLRDEFLAPIRAARTCEDPRSDPLFLRRLSESQIDLLQRPITEDEVVAAIGTTHPGRSPGPSGVPYELYQTAPKAWAKVLTKAYNAMIERGSLSPKQGQGLVRLIFKRHKKNADRAELSSYRPITLRECDYKIFTKVYVARLNQILPDLLPPQQHGFVKDRRSADAALHLRLLIEELGARRTEFPAAALLSLDQSSAYDLVEHDWIFAIFDALGAPATFLRVLRMLYSGDSTSARYIINGFLTAPVRLTCGLGQGDPASSSVWDIVFQPFLDALHRRNIALNLSIPALHPYPQSRAITSLAFADDVVVAVAGLGSLNLLDDLALDWRHATNGRLNTDKTVVLPIGRRWDPGQRPLVVKAAGESLEWIGLPFDPSGDTELAYANLIERPSSAKASDTLSSPSRAWGHSTCSTTWRSTGGSQPMAGSTPTRPSYYRSGRGESLEWIGLSFDPTGNTELAYANLIERLEATLEGVQHRWLTHHTRAFYVNRYAIPKILHFLAADIPPPEVVKKLDDMLVDFVPQGGLGVIRMQDVVDAVAARIWDVLLGGSGAIWQGLARAALQRAQSDLDLATDLWPHPSTPIPSDLHPRWRAALGVPKQQDAQVNPRTLTTANLLALPTLLGSLHTPIRGRQTIDAVHIPDYLRLQGYPKVADLYRRELYAGGGFHLWTPPADVLGDNSEYDRCGLPQRLAIAAWYWFTVDRHKNTRLAVGVAAGRLNVPPRIGTSAPLEAILPKPVARFAMEQRLPDPVLPQQASQYKLLNMARPYTIRRIRRVLNAKAFTNTLGLKGPPQPDDLRSFWKAVNSKALTAREREIWFKLFLRFTPTRKLQHQQKHDTSPACLVCEAPVDDTDHYFFGCVDSRNVWIAARGVLCDALGCDTIEDAQYTTLQRLFGLPKLKAKLSEQEGAGWTIEIFTGMVLEMISSGRWRMQKHGMRMESVERRRVVLELRMKLRAGGARGGRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LWA0</accession>
    <name>A0A2X0LWA0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C019g09007 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C019g09007</name>
        <name evidence="10" type="ORF">BQ5605_C019G09007</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY24052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LWA0"/>
    <dbReference type="STRING" id="796604.A0A2X0LWA0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF14">
        <property type="entry name" value="C2H2 TYPE ZINC FINGER DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G02360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="136"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="158"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="202"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="313"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="426"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="492"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="340"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="365"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="438"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="492"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="514"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY24052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1092" mass="118325" checksum="69B7B57611D05DF9" modified="2018-09-12" version="1">MQALAHGGVASASSSMSVGSGSGNGNMNRMLDHHRHGHHHAQDDDDKSPHRRALKKQRQANDAAGLSRSSGQGAPATGMPTPGEASTSKAVSGVVDPIEAAEIKPHVCDWPGCGKAFSRPDHLNRHKLNHRPATIYKCSKPGCPKTFVRNDLLIRHEGRHERKGQTGASGALSRNSVTSARKLQSSGTIPSEIPFLRSRVPSFGSASSASVDGVSPGAASSGSTPHPQASASASTRSPGRAGSYPHLAGLTPVGESAMPNHHEHRNSAMFNLQQHLYGPLSHAMGSAAAGPNNPPAYNPFTDPNPNPMPPPPITSFSGNAFSPPSGHPAANQLNHHQNEGAPNPAGGVYGPGAVPNDAPTPLFDSFNSDAPGPQSSMPGFEEPLNFIQQSYGVPFVSASEYSWLFDPTGGFDIQFARSRPVSPGHELLAFNGPGSVPGGQTSNSNGTGRTPGSGMSPEDLQEVTRGLGLHAQVQNGGYGRIATEWESINRVNSPGQRQNAPESTPQSAVEEVKPTPPPVIAPSPRTDPSPMPIVSIAIRAAVQWRPRLTTFVEQTSDSESATFPAPSNSAARGNVDRSTYIDERTRLKVIDYLEIEGKPLRNDPRMSRAAMVQYLEDFWLRIHETQVPGIHRASFKTNRTKTPLLLSMLLLGCYFGPLESQQLAVKLHSFFRGKVICSAEFKPRTELWLHQTILLISVFGKLCSTRLHHEMAHIFWSSCVTLGRRSAIFSQRAPAVMPKGKENDVEARWAAWIEEESLKRTALIIFALDVEHASLFRHSPALSAFQIQVQLPCDEDEWEATTAQEWAILHAQARAPAPFISALKASLMAGHSPPVLNSFSRIAILHGLLSVAQDLQWRDHVIGLSQSERAHNWRDMISSSYNSWKSRLDTCLAGVTAPTTQLLRASISLYAVAHITLSIDIHELQIYAGAESALGLLVSTAVFHATEARIRMWSSTKDARAASWHAAFFLRDSMQHYEHAKEDLAGCLHHRWCVYIATLTLYCYGRATSGRPGPRTADYKGSALRFLDSLCCDSPESLLLIRGKNNVLDLCQMIQEYIETSRWEIAQEGARILRRLLTNSCPGPPNKGSLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LXK3</accession>
    <name>A0A2X0LXK3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C015g08029 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C015g08029</name>
        <name evidence="6" type="ORF">BQ5605_C015G08029</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY18283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0LXK3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
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        <property type="entry name" value="DBL_dom_sf"/>
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    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR041675">
        <property type="entry name" value="PH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
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    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF1">
        <property type="entry name" value="RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="855"/>
            <end position="1068"/>
        </location>
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    <feature type="domain" description="CNH" evidence="5">
        <location>
            <begin position="1284"/>
            <end position="1598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="20"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="83"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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            <begin position="137"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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            <begin position="199"/>
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        </location>
    </feature>
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            <end position="517"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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            <begin position="529"/>
            <end position="601"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="731"/>
            <end position="750"/>
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        <location>
            <begin position="1170"/>
            <end position="1201"/>
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    </feature>
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        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
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        <location>
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            <end position="217"/>
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        <location>
            <begin position="225"/>
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        <location>
            <begin position="348"/>
            <end position="365"/>
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        <location>
            <begin position="571"/>
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        <location>
            <begin position="1170"/>
            <end position="1180"/>
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    </feature>
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            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY18283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1661" mass="182247" checksum="4D35459B891679CC" modified="2018-09-12" version="1">MSYHYNSDHYDDYHYQSTSAATFPSASSSSSSYLHTKQPPSADAPLGQAPPPQALAPPDLEVPFYARTCAAHGEELRLRHSITAAPSQPLRPSQTQYDHNPAGYDPSHPHPGYARYQAPVLATAPVPPSQPYAIAAAASAPRPPPGAYAPLPPTAPPRPPLPPGGHSSSSSLPVNSVSAPFYPTVDDYTARLEALQMGSLFPDDSSSSPASSPSTGLRPPPPRPLTISPPSNSSLNHHRHSSPTTPDQLYPRDQRDSFTSGFIAMYGGSPSPQNSPLPFTNNLSSSSVQYQAQQRYSSDSLTAASPIHTSHLSNATAMAMPSPRSPPVRSQAAASLAAVTGISNAASTSASASNNSYPSHASHPSTDSSATRSSNGSLPRPLPHEDSFYSVASSTWSPGQPGHQHNSNHSSTYSSHHTRKSPPPQHQPYEAAPLKPSRPPHFVHSSASSSSGRFITDGQTLDYSNPPRSGSLEHFRSTASPTEWARAKAITGGESQFEQQQRSQRSDQPPSIPATVVASTPFSSSFSVPGLTAIDESESPNPAFTVSPVESPNMTTHPVFSRAPKRSMTGSSLSPHVPSSLSPSTSYHSLKRTTSGASTSTQATTMYATQIPFSFSAADLPEFLNPALLSHLAVFLRDYIPRSTHTKSNREYPRSFTSQDIINTLQCALVAGPCPVDPHDRKLALSIARSLHESLWFHEVDWSDAPIRDAPAPTLNEANSTNHRLYQFDDDERSEVHVSKDETQDEDETPKGVLTTLTGCYSPFCNQLEDEETRYRCYAYDCSNRAKRGTALQRQTSSISTLTVAETVSSYLQSCGNESRTDLVGDIKQIDKPPENWVTSVPASVVSSMSKHEIEYQNRVYELIKGEAEYYHDLELLDSLFAQPLRQANPSILQPASRVEPFIAEVLQNVGEVRKHSGAFLDALQERQRQAHVFHGVGRIMLSFAVDWSPDYTKFAVNFPFADAAVREEMGRNPKFRDFLGVSRRLACHSGESTKTNGTHLHQQFRYRPETHRHDFHHFHTRATIRGVRYLLLLKDILKLSQEDDPDRPYVLETIKVIEQQAAEANKLIKVTETKVALREYDRDLVPKREGENLSYLELKNEQERQYFGSVKVLKRVDGAVGTEWSECWLVLFDHYLVTTKMPREKEGRKRYVMTRRPVPLDLIQLKTTSFSDPPQQRTSGFHLRSARAGTPGYADSPSNSSSTSLVYPIHFYQMGRYDGQVYFYVESQATRLEWEHKFREAVDLRAQRQSISKVIRMDLLAETTFGAAHVVGSLDAMTSHNAVGKPTCSVPLDLADGQALVIIGCAEGLFIGYRGRPKSLRQVVALSGITQCAVLPEYGFVLVLANKVLIAYSLEALIPSGTTSNSSVSRAPQRLSGQKDVSFFRVGKIGTEAPKTLIIYAKKGGVKESIFKALEPVNHSHKGGGGGAGHKLFSFGSSKTESFKSYKDFFIPALVSGLQFHRSKLALIGSRGVEIMDLEDMKTMTVPAFPSSRHDRSLVSLAERCEKAQALGMFRLQGDRFLLAYTDFAFHVTRHGLPIEGFTIEWESKPESVAFLSPYIFAFSPTIVEIRHALTGQLAQFITGSQVALIYDGTAIPSSPSNDSLPRESQSSDEVAPAEKRLHFSLKSGHYHLVYEINVLPGFQSIPEAETPSFPSGFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZB8</accession>
    <name>A0A2X0LZB8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01656 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01656</name>
        <name evidence="2" type="ORF">BQ5605_C002G01656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY34595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="207"/>
        </location>
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            <begin position="443"/>
            <end position="477"/>
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            <begin position="1"/>
            <end position="22"/>
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            <begin position="40"/>
            <end position="66"/>
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            <begin position="67"/>
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            <begin position="145"/>
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        <source>
            <dbReference type="EMBL" id="SGY34595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="517" mass="54458" checksum="7FBEAB973EF6247E" modified="2018-09-12" version="1">MNHSTSCGGSLVQIQIQTQATPSPLGRRIRPSASVPDLTQQSQQQQQQQQQQQQQQQQQQQQQQQQEPNSGAPANTSSPQTSQPGTAPRNVRFTTDATAGNSPLSSSSPRRTQLSRYPNLNPGATSSTPSSFSPVPLTRVLSNGSTPLSPAPTALASPSPRFPIARPLSTSASASASASPSNSRELSHINTNKSATPHRSFSSGWTAGAGNTTPVKAMAPLAPAAMTSSIVATSVAATRSSAASSTKPELSTTKRRPLPPMTRQEVARRLRTNAVLLVLWWISSRTQVYKYTSDHLSDLLPSLSTPLNLLEKGLFILLCYNVADSMCSLNSLSSLPPPRPSTPSKSSSSPHLRRTVSGTPQFSAPVQSSPKTRSTCFASPSILPGGSPLGGSSSINTMSGSPTRTFRASAMSSPQPPSPQTPASSSRPIVASALRKSYVGELRTNASPSTQGSPLGTRGVAGTPTMTSSDTEEMSSLKSSLIAYMARHEPSSHQSRCTAPKISVDSQEAIDRMFESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZP3</accession>
    <name>A0A2X0LZP3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C002g01723 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C002g01723</name>
        <name evidence="3" type="ORF">BQ5605_C002G01723</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY35070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052925">
        <property type="entry name" value="Phage_Integrase-like_Recomb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34605:SF3">
        <property type="entry name" value="P CELL-TYPE AGGLUTINATION PROTEIN MAP4-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34605">
        <property type="entry name" value="PHAGE_INTEGRASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="260"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY35070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="275" mass="30824" checksum="C20E31B0DF2ABEA6" modified="2018-09-12" version="1">MWTMQLAAAAATAPAPKPERLAATSDKDEEFIAERHLAVANARRIDATSEAPLRFELDLPFDKVRRRVGRTLVVSARDGEPFCPVGGINNHFRLNDLPPERLFSYRAREGGHRQLTSSAFSRRIKYILEASGRAVLNNHSFRSGGATFYLREGVHTDHIRNLGRWSSNTFDGYWRQHKEIAIQVLSKAGKLALDPVTYGTRPAPGRLSERGVRELGCTHHPRVSSRKINHLSHPNTTKHTERYTRKVAIPFPRSRTPLASDRDIGGEKRGPGAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M0F5</accession>
    <name>A0A2X0M0F5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C003g01975</name>
        <name evidence="12" type="ORF">BQ5605_C003G01975</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY38187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0M0F5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="11">
        <location>
            <begin position="983"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="172"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY38187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1393" mass="157267" checksum="394927829B0B0A8A" modified="2018-09-12" version="1">MPAHRPKVLVNYYCLILSIVLEHRCTRCFQFFFDNDQDTAEVWYSSDAASHVNKKYGVFQRDLTLRTLPSDYIISMAACDLQLELGVSLVSNTQLVRMLLLHMDEELSQRLQLSEVIKGTGLSPDELDASIVKANSTTSSAVFDYQTFDTEARRLWQVISVTRASVKATAQASARTVRSTPTLRTTASPSTLPPLSSKTRAPPMTDRERAFLRSNQDCFKCRKINAGHFKDTCTTWATSACKVPAGWQQGPVSPEQVASLSDAVDEIDDKGEELHCLCDDKYDNGMDDERCEPISLSVKLTTEDGPALRALVDTGASASFIADREVEKLRLTWRKLQHVVLKIAPLTSLKVVLGRPFLKRHNILVDCKRRRVLAPDPTLPGKCIDLMHRGEKGEWSESAVQASIRACLAHLEEQQAEESQLRALEVAFCKEFSDRFPADIPPVSQYESKVRHRITLKPGMKTPRQPTYGTPMRWRAAWRRLLDEHLAAGRLCASSSEYSSPAFIIPKKGMDTDPSIMPRWVNDYWILNAATVPDCTPLPLPDEILAVAARACFWSKIDMTNSFFQTKMAKEDIPKTAVATPWGLFEWVVMPMGLSNAPATHQHQVNEALSSLIGKSCFAYLDDITIFSDTMEDHQTHVKDVLEAGQSVLFAKEDRTFSNILRLFGEYHFAKRDCSRSVEGGAKRGVARSVTELWRFLGLVQYLRKFINGLAQHTKPLADLTLKNTNVQLMWGAKQEQHFNAIKAIVTSLPCLKPIDHTDSADPLWVMTDASNVGIGAVLLQGQDWRKAHPVAYWSCQYISAEVNYLTHEQEHLAVVDALRQWRVNLMGVHFHVLSDHKSLKYLKTQENLSKCQARWVERLADYNFDITYIPGGKNTVADTMNRYSFPQGEPDSVQAVSEMDVDTQLRGRLVEGYDSNPFCQQVKRNLDSSPGFSCVDGVLYFEGVSDFLLAALQTSCDTYVSTCVVCQRTKATTTGALGVLHALAVPYGLMQEVALDFVSPLPKSQGFDMLLTITDRLSGYTHLIPSLAADTTKDIAERFHEGWHRFFGPPMRIVSDWDKLFTSHFWRAYHNLMGTRLTMSTSFHPETDGRSKRTNKTAIQALQAVVNKQQNNWVRHLVNIEFVINASVNTSTNKSPFEVVLGRSPSLLPTSLNRPDLPDVPAAKDLIAEQKAVLAEVRDALAAAKVRQAEQVNRHRRPEPDIAVGDFVMVDTHDRRLQFKTGHRKSAKLFDCFEGPYKVIAANVATSNYTLQLSKGDQSHPTFHVSKLQPARPKPVIVDGHEEWVVREILEETTRGGKRYCVWWEGYPQHKATMELRENLVGTEALWRWELKKRMEGRVQGLRPLPEVQWKAIELLAYMLAHWPKVLVNYYCLILSIVLEHRCTRCFHSLWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M1T6</accession>
    <name>A0A2X0M1T6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C082g12986 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C082g12986</name>
        <name evidence="4" type="ORF">BQ5605_C082G12986</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000033">
        <property type="protein sequence ID" value="SGY28118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M1T6"/>
    <dbReference type="STRING" id="796604.A0A2X0M1T6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016082713" evidence="2">
        <location>
            <begin position="25"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="NADH:quinone oxidoreductase/Mrp antiporter transmembrane" evidence="3">
        <location>
            <begin position="94"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="NADH:quinone oxidoreductase/Mrp antiporter transmembrane" evidence="3">
        <location>
            <begin position="144"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY28118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="301" mass="33437" checksum="B8E6529A52DE22A5" modified="2018-09-12" version="1">MLTSLILIPLLGAVILFPMNDSTAVEVSRVKRVALLATVITFILSMILWAEFDSSSSSFQFTQSFTSLNFAKSLDVPKGPALLQNKTWVLGVDGVRASFLLFLYTLFGSLFMLLAFLVIFYHVGSTDFEVLSLADISFNHQRWAHVQADVSTSMVLAGLILKLATYGYIRVLIPLLPEATSYFSPLVQTLCVVTLVYSSLTILRQTDFKVLIAYSSVAHMSVVVIGLFSDTLQGIEGAILLSIGHGFVSPALFYCLGGVLYNRYHTRQIRYYRGLIQYMPIFSLVFFLFILGNMSTPLTIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M2R5</accession>
    <name>A0A2X0M2R5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C002g01522 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C002g01522</name>
        <name evidence="8" type="ORF">BQ5605_C002G01522</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY33658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M2R5"/>
    <dbReference type="STRING" id="796604.A0A2X0M2R5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018823">
        <property type="entry name" value="ArAE_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052430">
        <property type="entry name" value="IVT-Associated"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804:SF3">
        <property type="entry name" value="PROTEIN BRE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10337">
        <property type="entry name" value="ArAE_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="651"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="675"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="703"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="731"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="758"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="799"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="831"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="domain" description="Putative ER transporter 6TM N-terminal" evidence="7">
        <location>
            <begin position="148"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="385"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="507"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="394"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="507"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY33658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1065" mass="117586" checksum="7C33C557A666F3DC" modified="2018-09-12" version="1">MAPGWLPQVSRAQAMSTFKGCLAYTLVFALVFTRAFYRLNTYPITLSSMVIVSIAAQPGSSTGACLDAGALAAVGVGMGAVMFVILGHLGHAVVAQGFIFAIYVYFMAIIKAQSMRFFGLSLLAILMGFNGIYTSALLGGKYSAEYLKAYLEAYAWGFAIVFAVNLLVFPTSAERELRELMVDALEHMSTFTHLLAKTYTVEITQDERTVRDALNASIRADYGFLQQKTAQVALEVNWTRWSMADYSNMLARIRQMQQGLITSYSNLMVMEQYEPQSLQIIKEGLTERATGKTFLKLRKGIDLAITDIVQELGVGGRTHHPVAPGEYSWEDFLEYTEPSTDNNLESGEGRPKLLERTTSVESPAFNAGFRKMSLRLKNEVDVYSSTPVGSRRPSFNEEHTGKISPEHPNLNFDGTTGASTPKAATIIDVKPLDRADSIRQAWAAFKNHQNQHVADLLASGTLTDGILRVEQPGPSLRDAFLAKQPDHIAARGLMSSTAVRANITDASQRKDGKVKATDSEEKVEQMEEGTTSTTPAVEMGAAGVGPTGSPEQIAGTTVLRVLSFIFGMGQALDELTALHEAVVPKDDASRPRKKIHLHLLERARLSSPVWKGMPFREALSKLTGVSYADEKVTLWQRFGQFEKLIRSPTSLYAFKTTCAVTIFVVFILAPSLKTFFIDYSLNGGLITIVVAMAPVLGQGIFTWVIQILGTGLGTLYGLLILRIFLHVGPHYFNPYGLTSLLAVFAVPTCFIIYTKPMFFAGSLLALNAAGIAVITQYVYRDIPEARRPGFDSPAYRTGKSFAALALALGIAWFWQIYVLRTPARQTLRNKLAGITFALGTYATLFQMMTESLAPIRETEGYVAPPREAVEAVQHELIRREGRIQAELLALMPLLRFSALEPAFGHKFDGATFSRIIREHQVILDRLREARTAIGTEGFPRSIKDNFTTPLAPFRDQNKRFMRALFYLVGTSLATKKPLPHDLPTMLTAVKDLQHDALVLSHRLSVSESGREIVYSHEFNRYWFFLASMSTVSYRLEACESDLAILLGSVEASPFVINERPSGGFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M3P5</accession>
    <name>A0A2X0M3P5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g01904 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C003g01904</name>
        <name evidence="1" type="ORF">BQ5605_C003G01904</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY37866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M3P5"/>
    <dbReference type="STRING" id="796604.A0A2X0M3P5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY37866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="471" mass="52004" checksum="61A94378E0EDF24A" modified="2018-09-12" version="1">MSAEAQKQVITRRLHLAAYDQVRPRSAPTCAHAIGVTLCGDLLQVYLVNASGAFTTNARKCDEEAVLLRRVLSRLIELDDDGLRMLASTNKVDDVFGSFVVSDKLFQPRAHDSESELGDVRDIEIWQKLIQRRNRAGLTTSAFHGTARHAPVDPISITPITSTSPNPAAEYAVTISWAEQSLLDDVIALRRKMHAASGADTEGLSLSAGIYRGGLRTLPAFFGDDESFDDIGPRALEVVFHRQCYRPLNTATTTRELAQAVLGVVKADTPIPTTMQDTETSTSWGISTGISRTITSLSTATVSAPSSIITSPSHMIDLVPSCTIEYDSCVLPSGTWPYLACSILAQPQQPLGVVHERWHDIESLFYVVMEIAFREPYKGNDEVLVMTPKGETIWRHWNSPEAHVVYALKYMLRMDMAYEPALEGCAHRFTGIQLLLDILRRNSQLGELWGPSKAMSHESIISDIEQLLLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M3S1</accession>
    <name>A0A2X0M3S1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C001g00573 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C001g00573</name>
        <name evidence="1" type="ORF">BQ5605_C001G00573</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY47780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M3S1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY47780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="90" mass="9953" checksum="AE36F2DE90B2AABA" modified="2018-09-12" version="1">MAASSILQLNLSNPRLYLGIALVLDEKIKDVTCDSDSALHSREGARAFTKVSQRKPDHVLQWISIELELGPSNDLRDVMTASLSSTNFRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M506</accession>
    <name>A0A2X0M506_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g03779 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g03779</name>
        <name evidence="1" type="ORF">BQ5605_C006G03779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY53606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M506"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY53606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="59" mass="6695" checksum="3B62B7EE6FFE61BF" modified="2018-09-12" version="1">MSHRPSRASPIHDARRNLDRATTDCQAHQHLTMVDKFPFVYVVQHDTPQSLDGPLGVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M5D4</accession>
    <name>A0A2X0M5D4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polynucleotide 5'-hydroxyl-kinase GRC3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polynucleotide 5'-hydroxyl-kinase grc3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C003g02524</name>
        <name evidence="8" type="synonym">CLP1</name>
        <name evidence="12" type="ORF">BQ5605_C003G02524</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of a pre-mRNA cleavage factor complex. Interacts directly with PCF11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Clp1 family. Clp1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY41527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M5D4"/>
    <dbReference type="STRING" id="796604.A0A2X0M5D4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1030">
        <property type="entry name" value="Clp1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.330">
        <property type="entry name" value="Pre-mRNA cleavage complex subunit Clp1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03035">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028606">
        <property type="entry name" value="Clp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010655">
        <property type="entry name" value="Clp1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038238">
        <property type="entry name" value="Clp1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032324">
        <property type="entry name" value="Clp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038239">
        <property type="entry name" value="Clp1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF6">
        <property type="entry name" value="POLYRIBONUCLEOTIDE 5'-HYDROXYL-KINASE CLP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06807">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16573">
        <property type="entry name" value="CLP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clp1 N-terminal" evidence="10">
        <location>
            <begin position="18"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 P-loop" evidence="11">
        <location>
            <begin position="245"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 C-terminal" evidence="9">
        <location>
            <begin position="391"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="146"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY41527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="513" mass="54930" checksum="B24FCD1C8CA0C434" modified="2018-09-12" version="1">MASTSGSSSSIPTRIIDLPPNHEFSFELEGTEALSITLLSGLAETFGVELVAHTAHPFSDQVRACVWTPTGCTIQVEGKVESSYVGDEGGMRVYQALHLGLSRIRAEARPSSSWTSTRRNKQLVAWTSVQDDEILPPRVLVVGERGAGKSSLIKSLLNWRVREAWALRGGKGATIKEGGGALYVNLDTSEGALTVPGTLSITPINALLPTTTPINPFGTSGTSGPPVPFPPNSNSTTNWLPPPLIEAYAPTVDPLVYWFGHQDPSDASSLYEHLLKKLGKSLGDKLAQGGLMGWKAGCLVDTPGEWAEKKGLAMIVKAVRALEVNIVLVVGNQRLEDQVKRLLDTNKTVSVVRVPAANGASAPDEALQRRIKDAQIRSYFYGGPALTTGVLSPFSIIVKFEDLRIVQIGEALSAQAPDSALPIGFGRTVGDLDLVPLDLEASNVQSSLLFRLLGIPQALEGSEEAEVVGRPVLGWVYVSAIDQVKKKMTLLSPLPGRLPRKTLILGSIDWQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M5U6</accession>
    <name>A0A2X0M5U6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00109 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00109</name>
        <name evidence="2" type="ORF">BQ5605_C001G00109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY44060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M5U6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY44060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="63" mass="6919" checksum="68904885A5A2DA86" modified="2018-09-12" version="1">MNMVVTLQKMKNNSLPWLSKSKLAEPSLRGSKEFRRFGSEEGSGENVTSATELWSEATAKAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M6N9</accession>
    <name>A0A2X0M6N9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C001g00409 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C001g00409</name>
        <name evidence="9" type="ORF">BQ5605_C001G00409</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY46295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M6N9"/>
    <dbReference type="STRING" id="796604.A0A2X0M6N9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15849">
        <property type="entry name" value="SNARE_Sso1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF307">
        <property type="entry name" value="PROTEIN SSO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="527"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="8">
        <location>
            <begin position="455"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY46295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="607" mass="67076" checksum="573E559E08DFE76D" modified="2018-09-12" version="1">MARDRLAAIRAQQAATDSQQQHQQNHSYPQQPQQQQLYGEYGRPSAEDNYGRPNMHRPPHESRNASFDDPGQYQSNPPYSRSRSNSSHGGSAARPRPSNPPPVSIAPSSNYMIPSYQEPPRDLNPYEPQAYSPIQAPAGQQPKAQKSQYTPLDPVRTRQRSISEGKLNPDQRRALEQSSMPPPPVPGQNYNSDKTRGYPNPPPEMRPAPSYQSFATEYDDYKGSSANLVSSKSRAEESYEMQKRRSNSNDSNRGGPSKKKKTVKRGDVEFEEMGQFFAEVSDLQERLREANGLVQQIAGVHARILALPSTEDPQSVALNQELNALTTSSRKLYNSLKNRILALDQGNAGLRALVPAAQSMYNLTMDDVDVRNTQVSALKERFKSAIQRYAEVERDNRNKNRSRMERQVMIVNPGLSAQEVNEVVRQAEEEGSNAVFSQALQQSDGRRGYAARGALREVETRAAALARIESTLVQLAQLFSDMAILVEEQDVQIVAIEAKAAEATHDMEKGLQQTQKAVKSARNARKWRWICFIIILIILIVVAVVVVIEVVLPMIKKNNEAKANAPAPTTAPATSTPIARFAAAAAITALPTASASTSAPTSTPARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M9E7</accession>
    <name>A0A2X0M9E7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C004g02963 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C004g02963</name>
        <name evidence="4" type="ORF">BQ5605_C004G02963</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY69120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M9E7"/>
    <dbReference type="STRING" id="796604.A0A2X0M9E7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006644">
        <property type="entry name" value="Cadg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05345">
        <property type="entry name" value="He_PIG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00736">
        <property type="entry name" value="CADG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="489"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Dystroglycan-type cadherin-like" evidence="3">
        <location>
            <begin position="51"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="706"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="815"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1182"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="722"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="750"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="765"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="815"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="854"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="906"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="918"/>
            <end position="930"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY69120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1203" mass="128110" checksum="19B6EAE9554618E0" modified="2018-09-12" version="1">MPKPISIPLLGDNRRTRSPNTFSMTAIGIVTFIAVLSSFLDSVLAAPSAPQLVYPLQAQRPPVARVGVAYSWTILPGTFNASSGSTLTLTSRSLPSWIDFDSASATFSGNPRTRDVGSHAVTIVANVTGVASGATDAFTLLVVTDPGPDVFLPFSKQLSSAAYAGGGGASLLPDGTLKVPPSWSFSLGFQQYTFQDQTNQYAQIYYTSYAAGTTQLPSWLKFDNRTVTFGGVAPSTPGDYSIVTYGSNYFGYGDVQQTLVFRVGAHILTMAENLAPIRTTPSSTVSYHFEFNDLRIDNASVTTANLSINVNLTNTSFLTYDASTQTISGTVPSTLIAPQNFTIPVLLTDQDNGTLATNVSMAIYASLFAKSTPSSIQLVAGQTFSQNLSSIATSTTATYSAIISPSSAQQWAQFDPRTLILSGTAPTTVQNVSVAFTAVEKTLNLTSQDSLIIAVVSPSSTSTGAATSAAAATGIHSGSPSGLSRAARLGLALGLGLGLGLLLLVFIAACLWRRKNKKRPYSDMYRRSFGVGTPTTFKFTRTGRSSTIVGPTYEGRISFEKRQDEKVGTQGPQYEEQQRVWAAPVVLPGGMEELSPRTVQSASPTQIGGFAGAAAIVKSSSSNVIKRFDLMGMFRSATGMLRPSSSQPATNKADISLPIVAQQNSLRGLGLSASSSSLALDEDGRRQYYGIRPNDHDIVDMRHHDPFAAPVGAGRHADDSGSDPSQTSRNDGLSSDLSEQSRDESHLERSSTWASGASSSLFYSESDRDSRHHRAGPERANKPRVSVPQQRKDFQALVISVPPRTSSAVHAANDSVSWMGSSSPSQSRQLYGASDESQSTSATGIRLVASHTNSSGGSAFPPSSGSSGYPVPRDTTDASLGDASFASSQNLPPPHVRPFTQERRVSSSSQAGSSYSSQTALRGTAGNRNSAIEDADESAAVYTTAGGTRMSARPVSAVYEPPSNDSRTISAVIYPYLDERDSMATTHQGRPSITASTYSEYTERGRVDSVRLIPGTVANSPFALSPTTPGTGSTWRYPSSLSGTSTIYSVSTSRTDLGMFDEDGVPPLPVDPIRVQVNINEPFRFHVPLPLQHSSSSTEFEAYLDPPGNTNGNRQGLPGWITFDETGGTKEVSGCARRANAGVLPILIVERSQPRDSRHSDELVEEQERVVARYEIEVAEREPESLTYPEGEEPQGELRIISY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M9L1</accession>
    <name>A0A2X0M9L1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C011g06385 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C011g06385</name>
        <name evidence="5" type="ORF">BQ5605_C011G06385</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0M9L1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052811">
        <property type="entry name" value="Glucose_resp_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010439">
        <property type="entry name" value="MUN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014770">
        <property type="entry name" value="Munc13_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014772">
        <property type="entry name" value="Munc13_dom-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47263">
        <property type="entry name" value="ADENYLATE CYCLASE ACTIVATION PROTEIN GIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47263:SF1">
        <property type="entry name" value="C2 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G02350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06292">
        <property type="entry name" value="MUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51258">
        <property type="entry name" value="MHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51259">
        <property type="entry name" value="MHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MHD1" evidence="3">
        <location>
            <begin position="718"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="935"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="domain" description="MHD2" evidence="4">
        <location>
            <begin position="1220"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1420"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="406"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1443"/>
            <end position="1453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY12085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1470" mass="164982" checksum="42A5BBCC975302CD" modified="2018-09-12" version="1">MPPGTGRSSRSTASSSHVPREDNDVYQYALRFAVLHSVLRAGLESDADDANEAGAAGAASGLGSASATTSTSTITASNLTAKQRANNLKLSTTSSSAMGSSLRPADGWTNALLSVGDVFRDSSGGSGSGKSVKFPKEFVKVLDGKLVKIFQGSDPKHDDKLFRATVGAFYGTYKDKSFQTKLLQNRGIEEIILTFVTIASGYLRKRLEGDDWKEHLNQHVAEFVMVLRDGLKLCRGVPSELLLRLDSYCSKMQTPASAGGPNSASTASTNKDLSSSASTGSAQASTSKLTLDTHLTPPIPGSANVQDMPMVLAIGKLFGKSIADLNRDYFPIRRTCTEQSAFNDLKLCINNVAKGARFPARREDFDSDESFSTWRKQESDTLQEYMLNMIKRNPNLVRSASSTVATGETGSSTPITGSPSLRRSALSVDGGFSLNSEDDSEPLVDPAFVFVPPDPKFYYRRLYEIALNHDYEAMRDLPPDQDVSLTILSPLHEELLSGCATRWRIMAPTRAGTFLSLIGQHYKFQAVPEACVAQALSDLAQVVEDWEYARWPWADRDYLFKGLSVLFDTLLSRFFEVFQGLLAISLEEVVDLIHEVHTNEVFREDIRDLDATLQELQQGMRKFIVMMYEEKQLEVIERSPPGNALHPFLTMLDWITAEAKSYDTLFPKKIVDVIDPPALFLGIAGPWFVQHLNSQRQTLLDAVTRNEGEGGANDADILDLYRAILALQRMHGAFCPKCVFFHQFLTAFSRLTLVFCSLDREPLKVEFSSWFEPYIRKWLQRTDAKTTEWVKAAIHHDTFEPEGADGHSSSIIDLSDSCRSAADFILKLNWPDSYDNARYLTALSQIIAKSIERYASALEAIFIDEMYPRGEQEQDPEAARPSAWLTKAKMVVQGDKKIQPFVFKPETCVKLNNIQAARKLLDIMYTTLDADNVSRTVESHQQTEAPQQVLQPTRYLFTVKILLGENLAPNDSAERKKLDPFLILSDPQGYRVAKTRTLYDTNDPRWDETIDISVKGDLWLRATVYNRNLVESHDNYGCAYVHLDPKEFSDFMPKDLWFQLEDTKRRRLDSRISFRISMEGEKDDIQFYFGRAFRWLKRAESDMVRIMVDKVSRLIGTVEIPPTEPVLAHIEKMSPFVRHYISRNTLKALVKTSYNFDIDLDKVRGDVVKVGGKLNAYVRDAINGPSYTIPPVEEYGHYETTASPSEKKKGRGPLTDLEIEDAIGDLFDYFNDTFGTLKTSLSQDAWNLVISRLWKVILTTIEGLIVPPLSDRPTPLKIMSEKELDIVFKWLGFLVNFFHSSGDGVPLEDLRNAKYRELVEARMYWDWTTDQLMEESVRSMQRSMLSKNDSLLSRSKSVYQQRNLGTIRARKIEKKQTSSTSGEMILRILRMHRLVRYSSGTSDFIAQQLATIASLQQESARLQQGRGGKAASGSLQRRPLNNGGKQLSSSRLGRSQGAPAVPKLPRTYGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MAL5</accession>
    <name>A0A2X0MAL5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g04264 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g04264</name>
        <name evidence="1" type="ORF">BQ5605_C006G04264</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY57378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MAL5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY57378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="51" mass="6200" checksum="CCEE9632D6EBE00F" modified="2018-09-12" version="1">MTLRQWQNWMVEGTTLRCGRHAKPVVWETESHVPHRFDGKWNLGERRLKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MB66</accession>
    <name>A0A2X0MB66_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit OST5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C007g04444</name>
        <name evidence="8" type="ORF">BQ5605_C007G04444</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the OST5 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY60520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MB66"/>
    <dbReference type="STRING" id="796604.A0A2X0MB66"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007915">
        <property type="entry name" value="TMEM258/Ost5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05251">
        <property type="entry name" value="Ost5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY60520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="82" mass="8524" checksum="8922E1AADF2D5D03" modified="2018-09-12" version="1">MSSYAGLQREHASSTPFSPLISPSAAQPLAIVLLSIAFVSSFYFSTLRPSKIPTTEIASALVASVLGGFGLVFAFCTLGVNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MBL9</accession>
    <name>A0A2X0MBL9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C007g04604 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C007g04604</name>
        <name evidence="2" type="ORF">BQ5605_C007G04604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY61808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MBL9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY61808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="272" mass="29880" checksum="DFDA4A7ED7AE8B24" modified="2018-09-12" version="1">MHRYKDETFAKATEASITTVAKGTRLRFEGTPHRDPSKVPNTAYPPIQRNPPLIQLPGVSSVRPLPPLPPLSSIQDLNLRRHLAKARRLQAEQPARMASTRKLAVQGTVKAPNYHLVEPDFKDSQVDSQHKSKSAEPKKRGQKATTAAEVWALFSKQSDSGSSGGDGGSGKTPGGTIYRMSTVTGTLEQMVREPTMPSELKQGSLRVRRAMARTTVQEVGASAPSATRHRTSSEHDDSMSACTAWMSSVTWLRSAIPVRARRDRTDADRWMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MCG7</accession>
    <name>A0A2X0MCG7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C008g05246 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C008g05246</name>
        <name evidence="5" type="ORF">BQ5605_C008G05246</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MCG7"/>
    <dbReference type="STRING" id="796604.A0A2X0MCG7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009074">
        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052780">
        <property type="entry name" value="AAA_Catabolism_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="95"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="137"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="305"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="972"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="150"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="330"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="347"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="418"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1044"/>
            <end position="1055"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY79893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1120" mass="120867" checksum="4458CA38FF30C9C2" modified="2018-09-12" version="1">MSPRPIAPFIRGKDGDRDRDRDRDRDHHNYGSSSDESSSSAAAPSHGGRSGGGRAARSGPGSAGPAPQTGLARRQSTSDSTGEVFSRKPKRTYRACLPCRSRKLKCDLGDPDAPSEGPCRRCRRESRDCIFNPRPARNFELLPSRGGGQSAPSSGSVTPADPTASNLPIPQHAQQQPPSHLSHVQNHHHSQPALPPVSSGPHDAGSAASTSAHVQFDVANPYGFPLLGMAPGSIPAWAATPSMYSPHHAAAALMAGTRLPSPSALVRGTAVPQFFMPSPLSLPTRQLHPTPTNLPAMTAPTYIRPALPSRASGSSEQNPHGSKRRKAEDYEPPPIDEGDEEDELDGLEGKEGREDGVHGGPVEDVTLEEAVERARGDRSRASSRNRTGNSRVLLASTLHNPSDALRLLATASSLRSTVSGDGSPSHQNGLIASPDVEVGGTTTPQGGAVLHRKESHQSGRMSPSRVAKLGGWSNWAPIAEGLLTQPEAEVLFSFFEAEMAPLYPLLSPNIFHLSHLAILTSTESLLLCAVITIAARYSAILLPDRAAQIHALCAAWIRQELIYLLDGTSSLRHISSVEALLLLTEWPSSPLIHRTDAALARQEADEDQDEGERETSKALKTSNQYDSMSWTYLGLAVRLAQELGMHNTALYGLDARDGDGPSWESERILRAWIYCYNADRHVSVRLGRNAVVQSYMSSAWWEKVTQRASLDVQKRGLNELWAERTLPQGLLAALMGTIQERLYPNKEITRSLLRTGHWESFIRSLDHELRSMATKTKGVLKQGNVESTLLRIEIDYIRLYGNAIALRALQERLRRRVKANDLLFVSPSLLNLQEGPWIIDALAAAQAILQQTVIFLEPKGYLRLCPSRIFQRIMFAATFLFKALAVGVVEHGQSKTIGLLEQGIAALRHASVDAVHISRGFSVLLTRLQAQCVPAVLAEEGLVDPTQPSYPPSPRGLAIVDDATVQATMHGLHGDNDSVLGEVPIDPATADDPTSVMKGATPSGGTAGDSMSVFGETINMHGPPDTRHHHHAQNSSNPHPPHQGNGTDPNPAISTSASEFGLLAFDLPWQWDPTLNTVDVGKEQDTLFASIFAMNQGGNEAANHGDQLGLFGTLVGDDAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MCM6</accession>
    <name>A0A2X0MCM6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C004g02677 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C004g02677</name>
        <name evidence="8" type="ORF">BQ5605_C004G02677</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP14 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY66463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MCM6"/>
    <dbReference type="STRING" id="796604.A0A2X0MCM6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007276">
        <property type="entry name" value="Nop14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23183">
        <property type="entry name" value="NOP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23183:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04147">
        <property type="entry name" value="Nop14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="121"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="292"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1068"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="230"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="317"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="453"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="473"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="525"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="552"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY66463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1093" mass="121586" checksum="9FBF20C2D9E7AC2F" modified="2018-09-12" version="1">MGGSQLTALKSTLREAGLSRTSNPKDQRKKRRQTKALSSTSLAHRRSQLDAIGQKFNRFDRTDEKVKFEVVTRKGQIEKTPGGAPTKSRTAGIELRKKTLLPLLEARSHVSTFVDRRFGEHSTDLTPDEKALTRFTAERQARLDEPLPASSSREKGKGKKARFNLEEDEDAYSGEEEGVELTHGGRKLGFGDEEELEHGGWGGLGAAVEGGASSSNREPLLRRRIAASMTDHDGDNEQREGVDEGGRKLTHAEIMEQVVAKSKMYKHERQRIKSADDEIRHELDQELKDLRVLLGGTGRMPKPTVVKEANAEGRDDQQDDQEDDDDDEEDDDDDEEDDEEEDDDEEDDDESGSESDGSTYSLNDEQLEAALAASKKPSGVDRELLRKLIGGKSDESESETEEETAHAEKGRLAPAPVYDLGDVDSSRPVAAAPTEKDNADPYDSYVRMLALEPRGKPSDRLKTPLELAQEAADELKKREDKRLKRQRGENDESDEEQGGEGKKKKANKRVPQADDLEDDYLGDMADGGGFEGDETGIGKGLGEEEMVAFNISDDEGEDEDEEEGSNDDAEDDEDDDDDEDEEVLDAADFDDEPEFDQDDDENKIESLVKALPPKPKQRPDANSVKRELPFAFPCPSTHAEFVKLLASSGVEEAETSTVVKRIRTLYHPGLSPSNKEKLQVFTHVLIDHALYLASTPSKTAFTTINSILPSLLTFSHAYPLTTAPYYINKLTTMQKNFVRGVSRGPLDPNSATWPGPTELTLLRLIGMTWSTSDLSHPVAAPAMLLISQYLAQARIRSLRDIAAGLFLCTLANQYEALSKRLVPEALNFLQTTLIVLLPTGYTVKNVPGTFPLPDFGQEHVKGLRLSTKASAKLSEESKASPSLDFFKTLTEIEDDDAQAKADLVLVAVELLTSFAEMYVVGLEAFIELFDPVQQIVSKALAKPLPKALEVSQTHRTDTIVISLKRMLNLSRSSRQPLTLQHHKPIPIATYIPKFDEGFNPNRRFDPDTERNEANKLRSLVKKEKKGAIRELRKDNRFLAGEEAKKKREKDVAYEAKIKKIMVGLADERAEEKKEKGIKEHGKKMDKARRGGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MCN2</accession>
    <name>A0A2X0MCN2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C013g07264 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C013g07264</name>
        <name evidence="3" type="ORF">BQ5605_C013G07264</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MCN2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY15140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="999" mass="110783" checksum="FFECAC9DB308DDDA" modified="2018-09-12" version="1">MAPKRRPRSSASPVRGGKRRNVPDVSRAEPCSQPSKCTTCNVQPPLDTSSDTALASCIAILSYALTAVNIVINIRLVVQVKAVEVPTVVTVVKVVVALVITLPVDMALIATVKVVLALDTTVNVDGVLLFGPDNEAVDEHWVLEKGIIPRVVIRATSALVQEVFEVEQTHFVSMAQRAQSSAKVIRPGQDKATRDLYRDRLKEEHKLVMATGARSWVQGMARQAQEPASGRRGRPKFKLAVAAAERAPRPVVKFDKFGMCFKYSHIEEQDLSSKHCMHFLACDRTKFDKSQVPWERVLVPFSFGLSNPAPRGERDRDYVKRAPQLVKLILDLHDHVLPRPSRIFAPGLAVNEHDAHLVVLDHDVCRIAVISDCWGSGYGELSAMLSILLDLDVYSAGFAPFLRYKFPLSGGVTAVSLLSAVFQSSSQHDNHDQQPVETPLLGRTVAFEDEEPIELVSCSTSDSNSVFGPCTTVFRLTRPSLHESEGEIGSRSFVLQMQHVTPNFVGGEAEMLRSINLAHDSGVLPSETVNHLAMLEVATSLRPHRSQVNDHLLPRGKATGIHGYNRDNMLRIKVIRRTLDLLILRNPTPVPRILASGPGMSLDSPAPLEHVLQVFDQLLTVLVALHRGGFYHRNLALDNILHHEGHLVLSGWGGGVAARPGEVVPAAKIDEDGGLWMTRWTAPLNVLRWNLLVPGDDLRNYDLSHALESSVYWFLLVLGQLIAPAGEAIWSEMFFQPDPARDRDLTRFSLRRDALWAGEPNFAPRFRDLLLASIGHALPALADLVEYMTRRWPKLDARRIRTETAIAAIQRQVRRLAQGADRRGRLGTFIEAMSDVYHSWVNCGRFFPLSLRSRNVFANTPTRFLASGYSQDSESRTFPSTFASTEDSIALPRELLLPATTRNSSGLIRHVYPVPALELDNMSIGEKVEYFRERAKLAPKNSQVDHINDMGLDLLPGDAQTFYSADSVENESLFSIEYLQSLNITGMALLHTTRVSTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MCT8</accession>
    <name>A0A2X0MCT8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C004g03019 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C004g03019</name>
        <name evidence="2" type="ORF">BQ5605_C004G03019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY69473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MCT8"/>
    <dbReference type="STRING" id="796604.A0A2X0MCT8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237:SF9">
        <property type="entry name" value="NEUROGUIDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY69473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="405" mass="43601" checksum="6B574AE68084E1B8" modified="2018-09-12" version="1">MASTSTFEPTADEVSTITTLLADVRSGASQLRQLDATSDLDDSKGISLLSLKNHLLLSYLHHLVALLQLKLACPTTSLTSPEGSSLVATLIKHRIVLEKISPLEGKLKYQIEKLVRRADQAAHGVDDEEMMNDPLAFKPNISNLVLDRTVSEDEDDQEERAYGGAMMNDDSGSRPGGIYRPPRVAAVPYTEAPAKGAHLLPESTLDCKDPSLIRSSSEHNAGKKAAKRATASHLVTDMSTGLSALTPYGESTTGLSASADPTLTSGTARHLKQVEQYEMDHFTRMRMSKKDAKKRRAEEEEVAFGGLGAGRGGKRRLGGYGAEFDDLLGEISKGRNQGAYDAMKKMKRDDQRRSAGAAGEQGEGRGSNGLAGFDDGSRKKGSTKKNQFDRAVGRARTGIARAKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MDP3</accession>
    <name>A0A2X0MDP3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C005g03331 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C005g03331</name>
        <name evidence="2" type="ORF">BQ5605_C005G03331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY73963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MDP3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY73963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="54" mass="5933" checksum="FFEB977AF753E5AF" modified="2018-09-12" version="1">MQFPRYWGDLLVITARISSDIDQWPCVASDVLDMSSSPAGPGEGPQSYFRISSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0ME34</accession>
    <name>A0A2X0ME34_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C005g03471 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C005g03471</name>
        <name evidence="4" type="ORF">BQ5605_C005G03471</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY76175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0ME34"/>
    <dbReference type="STRING" id="796604.A0A2X0ME34"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050563">
        <property type="entry name" value="4-hydroxybenzoyl-CoA_TE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31793">
        <property type="entry name" value="4-HYDROXYBENZOYL-COA THIOESTERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31793:SF27">
        <property type="entry name" value="NOVEL THIOESTERASE SUPERFAMILY DOMAIN AND SAPOSIN A-TYPE DOMAIN CONTAINING PROTEIN (0610012H03RIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="199"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY76175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="212" mass="23305" checksum="4C75139505F1B217" modified="2018-09-12" version="1">MKPTTLRSTLASAAPKPKPARAAPPSLKAYRYFLPFQTQWRDNDAYVHLNNIIYNAYGDSIVNEYLINHLGLQLPSTDANHRPTPVGLMVNSSLSFAAPLSFPSPILGALSVSSVSKSSITWQVGLFAARANLDRSSISNGTQLALEDHSDATFPTRFDSSIQVIPGKDGQLPTAAAWGSMTHVFVDEKTRRSTPLPEQWREKLKGLQGRWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MFK9</accession>
    <name>A0A2X0MFK9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U6 snRNA-associated Sm-like protein LSm1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C036g11485</name>
        <name evidence="6" type="synonym">LSM1</name>
        <name evidence="8" type="ORF">BQ5605_C036G11485</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the heptameric LSM1-LSM7 complex that forms a seven-membered ring structure with a donut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000063">
        <property type="protein sequence ID" value="SGY95298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MFK9"/>
    <dbReference type="STRING" id="796604.A0A2X0MFK9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01728">
        <property type="entry name" value="LSm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034104">
        <property type="entry name" value="Lsm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF8">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="7">
        <location>
            <begin position="52"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY95298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="184" mass="20673" checksum="8E04F51AA87523A7" modified="2018-09-12" version="1">MRNSRGRLAPLPAAATGCDLQEAALTPDRRRFLAHSTSTHYTLDPLSNLAFTTSGALIDLVDKKILVHLRDGRRLNGVLRSYDQYANLVLTQTIERIFHPPSKTFAQTDRGVFLIRGENVVLLGEVDLDTEDAAIEKLQQHSWEQLAAVLEQEKQRKEQHTRITERVLHQTKGFGEEGGEGDAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHN2</accession>
    <name>A0A2X0MHN2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C031g10895 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C031g10895</name>
        <name evidence="1" type="ORF">BQ5605_C031G10895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000068">
        <property type="protein sequence ID" value="SGZ05856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHN2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ05856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="156" mass="17752" checksum="7BD6B09D8FE15706" modified="2018-09-12" version="1">MYDVTPTRKKQHVQGHASSPSCLFCGNDAAVIETVSHYFFGCAYSASYWSGVLRILFDKLGIEDTDVDPSTFTQEQLTMGLPLLRGRGRTTSKWMWVRLACAIGFQRLHLLRWDVHQRFEKDRVVAPPSIPSALRAFKRDFLSRAGFVPGARDWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHW6</accession>
    <name>A0A2X0MHW6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C039g11757 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C039g11757</name>
        <name evidence="8" type="ORF">BQ5605_C039G11757</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000060">
        <property type="protein sequence ID" value="SGY89571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHW6"/>
    <dbReference type="STRING" id="796604.A0A2X0MHW6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01736">
        <property type="entry name" value="LSm14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025762">
        <property type="entry name" value="DFDF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025761">
        <property type="entry name" value="FFD_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025609">
        <property type="entry name" value="Lsm14-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025768">
        <property type="entry name" value="TFG_box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586">
        <property type="entry name" value="SCD6 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586:SF0">
        <property type="entry name" value="TRAILER HITCH, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12701">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01271">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51512">
        <property type="entry name" value="DFDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51513">
        <property type="entry name" value="FFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51536">
        <property type="entry name" value="TFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="7">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="DFDF" evidence="4">
        <location>
            <begin position="433"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="FFD box profile" evidence="5">
        <location>
            <begin position="477"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="TFG box profile" evidence="6">
        <location>
            <begin position="509"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="77"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="523"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="FFD box" evidence="1">
        <location>
            <begin position="477"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="TFG box" evidence="2">
        <location>
            <begin position="509"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="92"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="253"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="528"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="545"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY89571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="575" mass="58599" checksum="E33E18DC000E841D" modified="2018-09-12" version="1">MADFIGSHISLISKSDIKYLGVLHSIDPAEATVSLEKVRSLGTQGRKSNPAEEIPPNDNVYDFVVFRAADVKDLQIEAPPATTPSQAPISDPAVVATNAAPPASAASAPQTSQPQQSPQQSSNQPPPAVSAQQGGLDQPPPQQQQGFGPPGGQQGQFPPYPPYGPLGGYGPPPGPPGQGFYGYGPPPRHFGGPGGFGPPGPGGFGPPMGYPNQFGPPLPQHQQQLPPPPHQQQQQQQQPAKSLTDDPAATSSPAVQNAVVPQPAVDSKAAPSKAAETAQAAQVPQAAEASKTAPTPAAPAVDAAASKPRSYANPGGAVPTPASDGEKQTADESVAKLTDDMSRSNLGGGTTKQAQSGGAQNGGAPQQQQQQQGANRGGRGPAGRVAGTDSVGGSVFSNNASNHQNPNQGNRRGSANGPGTGLGAGRALQPFGRPTAHVDVPSTDFDFESSNAGFSKDKVLAEGEEDEEVVIPKANDSFYDKKSSFFDSISSDVKTRAEGGMVNSGFTSGGRFDRDKERSKNMEAFGESGAGMGFGGRGRGRGGRGRGWGGAYHRGGYNRGGPRQNVSGGANGGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJA4</accession>
    <name>A0A2X0MJA4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C002g00995 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C002g00995</name>
        <name evidence="1" type="ORF">BQ5605_C002G00995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY28976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJA4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY28976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="133" mass="14935" checksum="3E8302000F0663F4" modified="2018-09-12" version="1">MQAGTLDQSGKDTHNIFLAFGFPLWPVHEHRSVVVDQHPVAVRCDHDVRSGNVPMKDAAHTLNGPQNNACQRFGRIDDADWLEAVFMERHLHRARLETPRSEGEIRREKVGDDDKVTLAIHVDDVGEPLSILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJZ1</accession>
    <name>A0A2X0MJZ1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C036g11533 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C036g11533</name>
        <name evidence="2" type="ORF">BQ5605_C036G11533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000063">
        <property type="protein sequence ID" value="SGY95999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJZ1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY95999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="44" mass="4643" checksum="3C08F595E2475062" modified="2018-09-12" version="1">MSSKVKNRASQPSVADKVNTKTVKKPGQGRTTPSDSTQDAQVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKN3</accession>
    <name>A0A2X0MKN3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ataxin-10 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Copper transport protein 86</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C013g07226</name>
        <name evidence="8" type="ORF">BQ5605_C013G07226</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">May play a role in the regulation of cytokinesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ataxin-10 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MKN3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051374">
        <property type="entry name" value="Ataxin-10/CTR86_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019156">
        <property type="entry name" value="Ataxin-10_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255:SF0">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09759">
        <property type="entry name" value="Atx10homo_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ataxin-10" evidence="7">
        <location>
            <begin position="414"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY15054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="512" mass="55805" checksum="C06DA8B9E292A4A2" modified="2018-09-12" version="1">MAAPTAEHLAQQLARVSSLPEELIQVVKTARLALRDDIQLRSIYGQSSSFWISFAQVWRNQAQLLARGDSTSELASTSRQAITSLAYLLLSICTNDQHNQRNAASKIEPHLRSVLLTASSLTNLENEQFTPMTRACCQALANLITGNEELATEVLKARLVLEKDDKLISRLFASQDSQTLEALLIFLLNVIHGSQERSTLLATWGDGPKVLDRMLVLIDSFTCDEEQVDGADPSAVKGKEAVFSLGYAIGEQLIENGAWAQAYENQRAMSGFVISASQTTLLKFLDGYLSEHFQSTPSPPSPAILSLPSSLTQLLASFTQELSTRDRSKDGRDANTLQGAVLAVTCLNSLGLHGTKGREAIAVGIGPTIALLAFANSLSTPTPQMPLPKLSLIAEDTSTSSTRTWIDPPAIGQIKRECVRFLSIASSDHFKAQEEIREKGGLVMVLGMCQIDDSNPTLREHALFAIRNLLKGNERNQALVAGLEPRYVVGRNGELRDLPAALRSDGRHTQDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0ML87</accession>
    <name>A0A2X0ML87_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C012g06699 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C012g06699</name>
        <name evidence="25" type="ORF">BQ5605_C012G06699</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY15911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="526"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="822"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1413"/>
            <end position="1479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGY15911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1479" mass="162254" checksum="0E57578A017C9255" modified="2018-09-12" version="1">MDDTSPPLATGVHPTFPADQLAALTSLLSGLTAAASGTVTTTTSSSTTRPAFPKHARLDGPKMFANWTRQLRLCLADDIRSYVLDGIVPVDWTPSQRSARDVVARELLANSIDSAEVSAVLDAIPTADLTAPKMYSTLKSRYAPDDATRTLELFSRLWSFRPMPGTVGEFDGWIMEFKAIAQEIIDTKTTINDVLATLLLAIAHPSLESFKASFTDEQRTQRSLPAIDSLADRMRVQLWSTNVPSTQSALLASSSSRPTRPKCLACHSPSHRVAECPVRAKHPPPGPCRSCKQNHWSFDCKKALENGKKADTANSTANSQHHVGCIATGFLARRRQLRTNSFVVDSGATSHMVSDKSLFTTYRHIAPTKIGGIAGGINAIGTGNIAFVAASGHPITLTGVLHTPGLFVNLLSVSRLCDTDDVRVAFTKHGIDIDKNGHNIAEGTRLDEGLYLLDADHSKCQHIALLSRSQSSVPLLTLHRCLGHLAPSSIQKMVAAGLLEGLRAGYSDEEVEKFVCNACLSAKGHRLPFPDSDSHSSERLGLVHSDVLSLPERSLTGKRYLVTFLDDYSRKLWAYAIGHKSEVFSVFKTWLAEVELETGATLKVLRTDNGGEYCSRAFTDFCKVRGTRRQYSIPRTPQQNGRAERVNRSIVEGILALLADAHLPKTFWEEAAAYFVYCKNLVQHSALDKATPNSVWQGGRTTASALHPFGCAAWLTVAPELRSKLDPKAVRVLFTGYDLASKAFRFYDTTTKKVTLGRNATFVDTEFPGLCGDSAEPDDDTHFASAPFADPQTTVKSWTPLYSADPLDLIGSQPQAALDPMDTQPPDFSTYREPASAEESPDELDLIGRHSRDESPDEIDFLTRHHRAFIATDDDTSDTEAIEPVKSITSDPQTWREAMSGDKREVWAKAAADEFNSMRDDFKVFTIDDRSTVPAGATIVSSKFVWKTKRNALGKITGHKARLVAQGNRQHDGIDFTETFAPVARFSSIRSLLALAATNGLHVHQADIEKAYLHGDLDHDIWMTAPRGFDLPGDKVLRLRRSIYGLKQAGRIWNRHIDASLRDLGYTATGTDHCVYSRLDDRQRPHYIALYVDDLLMISPDLAEIERVISGLEQRYGVKRLGPAEYILGIQIRRLDDGSIALSQERYIMDVLARFHFNTTTRGTTVPMTPGLSLTAIPGQATKRIRSWYLQAIGSLLYISLGTRPDIAFAVSYLARFANNPGHRHWIAIKHIFRYLRATYRDELVYARGEARITGVVGYSDANWGVCVDTSISTMGYVFYIAGSAVSWSSKRQSRVANSTTDAEYLALSHAGKEGIYLSQLLEELHVQPVAPAHIFTDNEAAAAVARDPVRVTGTRHIRLREHFVRDMVNRGDISLSHVGTSDMVADIFTKALGPKVFSTHCYALGLRTRHPRLGSASHSRGGGCKESTLSSTEAPRSSRAPASPPPCGGDLGARDCLSEQAPADSGARPLGRPLEVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLU5</accession>
    <name>A0A2X0MLU5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C024g09855 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C024g09855</name>
        <name evidence="5" type="ORF">BQ5605_C024G09855</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ26187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MLU5"/>
    <dbReference type="STRING" id="796604.A0A2X0MLU5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00924">
        <property type="entry name" value="Cyt_c_Oxidase_Vb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.11.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit Vb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002124">
        <property type="entry name" value="Cyt_c_oxidase_su5b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036972">
        <property type="entry name" value="Cyt_c_oxidase_su5b_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10122:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5B, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10122">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01215">
        <property type="entry name" value="COX5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57802">
        <property type="entry name" value="Rubredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51359">
        <property type="entry name" value="COX5B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602124-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGZ26187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="183" mass="20112" checksum="E1095EEC0314E86B" modified="2018-09-12" version="1">MFRLAVRSPVARAAVVAAPRMATRSFLTSLRRHSDAVPIIQTTTSDERHATEHERPSPRIAQLLTHSARTSPPQGPGGKPGRVPTDLEQATGLERFELLMKLNGEEAFSLDPLEVTRLGTLQDPITVFSLDNTRIVGCTGFPVDSHDTILFTINKEKPVRCPECGCAYKVDFQGVEDHGHGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLV6</accession>
    <name>A0A2X0MLV6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">V-type proton ATPase subunit C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C024g09865</name>
        <name evidence="8" type="ORF">BQ5605_C024G09865</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. Reversibly leaves the enzyme after glucose depletion, causing the catalytic subcomplex V1 to detach from the V0 section.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the V-ATPase C subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ26235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MLV6"/>
    <dbReference type="STRING" id="796604.A0A2X0MLV6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14785">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004907">
        <property type="entry name" value="ATPase_V1-cplx_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036132">
        <property type="entry name" value="Vac_ATP_synth_c_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03223">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118203">
        <property type="entry name" value="Vacuolar ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00053565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGZ26235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="441" mass="48824" checksum="77BFFB62EA555AEE" modified="2018-09-12" version="1">MNDATEAAFAFVVAPHPPPRNDSNQPRMFMPSPTSYWLTTTRADNSSSADQLEDLQRVLGHGKLGRAAYIDFPQFKLAKQDPAVSAALAKTVDQIRSLTSADSQSQSSGSTSAASSDRASPLAQHLVTDDGRPYLDYIFPSDDSAAATREPAWTWNRSKYRYESRSLQEIVEGLMKEVSSIENAQRNKSGQYGIVKGQVVSAQRKKTGNLSTRSLADVVSAKDFAGTSESEYLETVLVAVPKNLVKEWENSYERLCQMVVPRSSSKLASDDEFVLYGVTIFRRVKDEFSQKCREAKFIVRDFTYDASAIQKAQADLVALEAEEKDLWTDLLRLSRINFSELFQILIHLKVVRAYVESVLRYGLPAAYFGAIIKPEYKSVTKLTTALSEYFGTEGKGKGGSKKHGKGSSLEGTDATVAGEFANVLEGEYLDFVLFEIERVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MMR3</accession>
    <name>A0A2X0MMR3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C021g09279 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C021g09279</name>
        <name evidence="8" type="ORF">BQ5605_C021G09279</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000083">
        <property type="protein sequence ID" value="SGZ20464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MMR3"/>
    <dbReference type="STRING" id="796604.A0A2X0MMR3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24296">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGZ20464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="540" mass="61986" checksum="F8F9250903946F95" modified="2018-09-12" version="1">MSPIPTFIDIPGYGPVSLTVFVYGAVAVWIAAWIFSYRDGTALGNDRNRYRKDLYSPHTTWFLGSLPFVLATRHKSLETWGEERAKMDRNPEHHGKWLSWSAPYGRRIIDISRPDLIEYVQKTNFQNYVKGKQFYLNMEAVLGDGIFNVDGHAWTLQRKATSKIFNGNAFRGIIAQSIDKNIERLVTIIKRHADQGEVFDLSQLFFRFTLESFGGMAFGCDIGALSTETDEPVPFTAAFDYAQVVLNKRFQDPFWPINEFLDGSRGKMRDTVRILDEFCYNLIDERTRAGRNTFTSEKKHDSQTDLLSLYMNIRDEQGKPMSRKQLRDAVLNLIIAGRDTTAQATSWTMIRLLRDPKWIESIRKEADEMGHLEYDTFKHLHMTNAVFMEGLRLSPSVPKNGWQAVKDDQLPNGGPFIRGGEYVHWGDYSMAREESIWGPDAKQFNPARWIDADGTVKKMSNYKAHMFNAGYRLCLGMELAKFEGCHLLTAILKKFDLEFAEGYWENTPKLDTEDMPKYLPSLTLHLANPLMVRATVRKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MMT3</accession>
    <name>A0A2X0MMT3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g02107 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g02107</name>
        <name evidence="2" type="ORF">BQ5605_C003G02107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY38949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MMT3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015862518" evidence="1">
        <location>
            <begin position="18"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY38949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="81" mass="9244" checksum="C48AE19DB2767D7B" modified="2018-09-12" version="1">MFLILVGTIIIIIIIRNDHLTDSPFFMSSDCARCPRRCRNVPKIACGPENRLWWMYQHTVVSAAPACGVHVPIRSHVQALW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNH8</accession>
    <name>A0A2X0MNH8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C027g10441</name>
        <name evidence="11" type="ORF">BQ5605_C027G10441</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MNH8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09839">
        <property type="entry name" value="M1_like_TAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057345">
        <property type="entry name" value="Ig-like_TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037813">
        <property type="entry name" value="TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057991">
        <property type="entry name" value="TPR_TAF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25316">
        <property type="entry name" value="TAF2_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25577">
        <property type="entry name" value="TPR_TAF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="1256"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="1641"/>
            <end position="1711"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="1747"/>
            <end position="1821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1391"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1486"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1839"/>
            <end position="1863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="301"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1394"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1486"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1531"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1542"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1839"/>
            <end position="1850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGZ28762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1863" mass="204966" checksum="DCC989754420BA5F" modified="2018-09-12" version="1">MGKGFTLLSQKVSINVALNGKIHGNTELTIAPTTADLRTVWLHARSMNVLATALRLPTTTVPLAFSYIPPLAPTLTEPHNVHTYPELKRAVWRSTNEGEEGEVGIAIPQGSVVKLHPASHHDEANQAKKQDEWEPVVLVIEYEVVSPGAGIVVVAPDETNPSRFPHVFTSTLSEISARHWVPCLDHAKDRCTWDLEFIVPRVLYSASASTLSRPTDVDGQDGPEAIDLDDEEEVEWPVSVVASGELVEQVVHPERSDRVIWHYAQVTPVSVQQIAWAVGPFVVAEIAPTPKENAANAAAAEGEDDEGAEEEEDPLASHDGAKLHALCLPGREAEMANCVGIVRRAMDFYTSKFGSYPFTNYTVAFVDALSSGSPTFHSAGLTILSSDMLHPASIIDQAFETRHTLAHALAVQWSGINLIARTASDVWLVIGIAQHITSLFLREVWGNNEYRFRLKKDMIRCVAQDVQREPLSVPARLAQPEPAQLQFIALKAPLVLYIFDKFLRNAGTSLGLDKVLPKIFLDAITGDTSTTSTGNYNALSATTFQRMCRKACGGSADAIRNFFDQWVYASGCPTFVVSAVFNRKRMAIELSIKQECLAHLWAQSAPWEETGHLRPVACFEGQMTIRIHEADGTPYEHVLSISESFKRHEVPFNTKYKRIRRNTKRYQARQAAAQAAAAGDLEAAEDVALIDVGFGSTLWEEEVERERWQVADWTEEDDVLMSQATYEWIRIDAEMDWIARIQFEQPDFMWISQLQRDRDVVAQLEAIHALSHMCASVHRNPEKPAIHDTVVSSNLCKTVLVGNYFIRIRMEAALALVSCATNRADYLGLFHLFKLFQSWFCFEPAAETKDPFAFRCIPKTNDFSDMSLYFLKKALIQAISMARDEQGQTPAVVHQFLIDLLAYNDNLGNRLSDAFYIVSIINALGYSFAGTPPKRDLGIFGADEGTFGDEASSLEALEPALAAVERYLSTDRLVPSFQNAITVAGIEFKLRLMMASLLPEDRMSFFIYTRDGNYPPVRIAAFEALLLLNPFQDMQESIPLVQYLFAVLRDDSSRLVQRRLAQALVEILPFLAVTKDLGAAPETGLEEFGAGSTKKGDSIQSMLKALRKKPGRSNNFRQCLLQTLTHPDIDPEVRDCMLKLAEVTIRPEGEPLPKITFRMPVVAESPVATPVSATTPRLKLTNTQTASLPRIKLGGSTAAPPAAENPAPLEIPVPVPATVKPKKTKVKAPPKLEHAQASGMSHSDFTACKSMIKKLLKDKHVTLFQHPVDPVKSGAPGYWDIVHHPMDVSTLSAKLNNGDYADRYAFRADFKLIISNAILYNVQGVVVDLARKLDAFFDKQWDRIEATLKMMEVLTPAVPAAQMVEPVASASTTTTTSKKASEMRPPVLKLATNPLPPPPPPPPPAELPADEFAPTPTVPLSTGLSFKIKPRAPAPAPTAVATPPVRAAPPPLAPAAQKQNRGAASPALPTPSLGFKIKFGGAATTPTAPNGAAAPLTAAPGGPTVSPVTTPKPPKAPKPLKAPKMSRTTTDDATYGAAGSTSKQSSRSVGSNGDAAAGVEDVPRPFKEKKKRKEVNYADPPDDVIEPPSARGPVAVTEAYPTAPLRPLVLDEPKLPPPSTWINPNDRVDPKKVRQVMAKIKGMREAFWFLKPVDPVALPVYYQEISEPMDLQTMEAKLDHGSYATYADVFADFDRIVANCQQFNPPNTEPVWHVLMIQRAWSAEWEKASRMSYHERRSILALLNKILKEGASWPFRESVDTIIDQIPTYYSIITPGTQRDLGTIKANVEKDRYASIDEVDADVELMLYNCFKFNASPEHQVYQSGLELQKMWRGGLAKAKAEMNKKRTGDKASAGGPTKKQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNT5</accession>
    <name>A0A2X0MNT5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">BQ5605_C057g12677 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C057g12677</name>
        <name evidence="13" type="ORF">BQ5605_C057G12677</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000094">
        <property type="protein sequence ID" value="SGZ29388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MNT5"/>
    <dbReference type="STRING" id="796604.A0A2X0MNT5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990542">
        <property type="term" value="P:mitochondrial transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045315">
        <property type="entry name" value="Mtm1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45760">
        <property type="entry name" value="FI19922P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45760:SF2">
        <property type="entry name" value="FI19922P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="196"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="349"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="105"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGZ29388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="447" mass="47453" checksum="2D427945EF6CD230" modified="2018-09-12" version="1">MGLLETSISEEVPFHSEAQKRSSRDGNTVDRHEPSGSGAPPQPSSSSGSGLGFAHQDAFSHHTLSARESNKKIEEKNKVIAAMVGATLTSLTMTPFDVVKTRLQTQPSQNARSSFIPASHLPPPTSRSTTSPWPRQSHRPRPRHRESSVETRLASKLSTCCTKTYFNSNDKSLLCRFDPRHSTSSLPASHRFRIRGSMLLHASNGGALFANACLYPDPRHAVKATSSGTIGGSASAASPTASDRILDAVIKIARNEGISSLWRGTAPALAMSGPGGRLSTWSATTGGRRTAFDHAPQWAYAEVANADGRHLSKSYLTARHLLAGYEAIKRSITGGKGMGEGWQDQSLSSEFAVAFVSGAGSGMIAATVTNPFDVVKTRRQALVEAATGSGSSSTQAPLTKTFPILFDIANKEGWAGLMRGLTPRLAKVGPACGIMIASYEGLGRLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MP02</accession>
    <name>A0A2X0MP02_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C050g12475 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C050g12475</name>
        <name evidence="2" type="ORF">BQ5605_C050G12475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000097">
        <property type="protein sequence ID" value="SGZ29683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MP02"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ29683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="44" mass="4867" checksum="F4D3731AF0F81E21" modified="2018-09-12" version="1">MQRAICHLPSPPHWVSAPRHRNTTGDHVTQSSHRSGELLQKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPX3</accession>
    <name>A0A2X0MPX3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C046g12264 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C046g12264</name>
        <name evidence="3" type="ORF">BQ5605_C046G12264</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000112">
        <property type="protein sequence ID" value="SGZ30900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MPX3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1032"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1616"/>
            <end position="1635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2252"/>
            <end position="2278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1624"/>
            <end position="1635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ30900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2461" mass="275954" checksum="35231CDAF41BC4ED" modified="2018-09-12" version="1">MLEMRINVGVVRPPSKEQIVAAFQSIVQQLSTKGHSCQLVQVLRVIHVDTAKAYAHTVGDFSAFIHFDDASLFQHPTTTLKEILPSRMDLPTRGLDVTAVRHDYEKEAPCARCHFAGHVERCPLMQAANRKEAEDLARHAVMRGAGMVGGGEQTGVGRAATTTTNNIRPTANNNNTSEVVAPSRALGTDQLESRNRFAGLEVEGGQEDDIEEEVAGKEGEEKEQVEEGDEDTGAKADDEDSDSDGNAGAGIDKAGGDGKDDDKDNDEHDDKDEQDDSSEGSERRGDDVMKDGAEEEDEEMETEVEEEVEQEQGVQDDSIMIIDDGQTTITTVSRESTPRSPLWPPLSPETLAKSLREGAEWDRANAEAAARVQAENEAIINAQLDAQEPLVRHQFAEWGQEDGQLRFINIRGTGSRSNKKMKRSQTVADLSDPSDDPVDVKRVLNRVKGRAGKEVAGQGKRVTRSMSAAAAMQVEGAKAKAEKGKGVEEEKRWSDHEPEDDILPEFPLFEDNITAKSTWNVRRCMGIPEKRRDIYTYLSTFKASAILLQEHFIKPELWQCIKDEYEGKAFISKHCLTLIPADSPLIDAEILRTHSALDGRILVTSFRLRGDIRILEINNLYAPVDTKQRLTFFDKLHFHRTQSTHLRLLGGDLNDCPLPAIDRRNQGRHGHHWPILIGKLDSPYTDCIRFKHPLTPSFTRPNIVRKRPKSFSRLDYFLLQRTHQKRLVQASTIYDHPKDLSDHRPVSIVLVLLDERRDAAEPNNSLPTTSNQLHRINAATFKTAAFQGMLEGWLEGASGEEPVGELEVVLGNCEKEGRELARREHRERVERMAVLVGRVQDLEALPVMGDEETAEWTRTTEELRRAVNERARQLRIRAHVPEIATEERLSRPVHAKLAARSSDSKITALRLPNGELTHDIDVALDHTQAHFQRLYNLEPRDRDHVERLRDDFLAPIRSARTCDDPSSDPLFLRRLSEAHIELLQQPITEDEVVAAIATTHPGRSPGPSGVPYELYHTAPRAWAKALSRAFNAMTERGSLSPRQGQGLVRLLFKHHKIGADRAELSSYRPITLRECDYKLFTKVYVARLNHVLPDLLPPQQHGFVKGRRSADASFHLRLLIEELGARGTEFPDAALLSLDQSSAYDLVEHEWIFAIFDALGAPATFQRVLRMLYSGDSTTARYIINGFLTPPVRLTCGLGQGDPASSSVWDVVFQPFLDALHRRGIALNLSLPTIHPYPQSRAITSLAFADDVVVAVAGSESLTLLDDLALDWRLATNGRLNTDKTVVLPIGCRWEAGDRPLVVKAEGESLEWIGLSFDPTGNTELANVNLVARLEAVLDSARDRGLTHHTRAFYVNRYAIPKILHILSADIPPLEVVKELDRILVDFVRGGKRRSCYGKDVVFTPRFKGGLGVMRMQDVVDSVAARVWDVLLGGSDAIWQGLARAAIVRTHPAPDFDLATDAWPCDYTPIRTDLHPRWQAVLKVPSTHNAQVKPRTLTLANLLALPIKLHTLHYLPGAPAVSRSPYDVDYAAFAIYAKVADLFRRELYPGGGFHLWTPPTDVVVSNSEYDQRGRPQREHIVAWYRHAINRLRFTPIAQPVAAVRINGPPRVRPTTPLESILPHPIDPPQRLPRPALPDQSTQYNLLSMDRPYTIRRVRRVLNAKAFTDTIGFRDSLQPDDLKGFWKGVNSKALTAREREVWFKLVRNFTPTRSLQFHQKHDDSPACLVCGAPKDDREHYFFDCVDSGNVWIAARSVLCDALGLDTIDNTHYTAVQRMFGLPKLKASLRDQEGAGRTIEIFTGLVLEMISSGRWGMQKWGTRMEGVVRRRIILEESVEGRGGCAVVLLSSSRPSGKWLWGGPSVLTHLAFADDAVVVVESPAALSKLETLSQTWYEATNGKTNTDKTLVLPLGPNWLRDETAQALPTVQEGESFKWCGYAFFRHGDSKLFWTHVLDRIKAKARAARDRTLSPSGRVFYANAHITSTVLHVLSFDIPPQWFIQAAETALTDFVWGGPRRNTVARDFVFQAREDGGLGLISIGDIVHSVALRFWDAVAGSDEAIWAPLARESWRSLVAATRDFSPWGFFSSTARVEKLYRDSTRWGAVVAAARVTVPTIKSELLTLPELLSLPPRLPSLYAEGAKHAYDDADAVAKFAQIADLYWRDEGKGWALVGHRRGFWQHSKEPALRHEHVWARVGQKLKAKALLPKTAVRPARIPLKEDPHPRCFNFFGLTRPFTIRKLRRLVNTVRFPGKDGQDRALPGGQPQEPRVKRFPEGTSQSGRQRFWSWLHDRFASAAEQDTHWRLMYDVTPTRKKQHVQGHASSPSCLFCGNDAAVIETVSHYFFGCAYSASYWSGVLRILFDKLGIEDTDVDPSTFTQEQLTMGLPLLRGRGRTTSKWMLVRLACAIGFQRLHLLRWHVHQRFEKDRVVAPPSIPSALRAFNRDYLSRAGFVPGARDWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQ37</accession>
    <name>A0A2X0MQ37_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C044g12147 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C044g12147</name>
        <name evidence="3" type="ORF">BQ5605_C044G12147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000114">
        <property type="protein sequence ID" value="SGZ31332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQ37"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF463">
        <property type="entry name" value="REVERSE TRANSCRIPTASE TY1_COPIA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="267"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ31332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="493" mass="54102" checksum="029C1645264785C1" modified="2018-09-12" version="1">MLEVYVIMAGAAISWKSKRQTMVASSTAESETLAASTAAKEAIGLRNLASKLCINQGKSTVLHKDNQPCINMQNNHQLEPLLVGKLWLSKPNVAEMGPNLSTETYKPRTPPTPAHHDLSTPDYAPWPGFWGSSRDFPDQDSQAPPASDQGSPTPQTGDHSDPDLPISRADLAISTPCPSPRPEFPDDMDAALHLPPPIAYLASGATALLKTLPVDPTELIAPARDPPHWRAAMATPQADEWRLATQAEFDLLSREFLTFTPIDESLVPADSKVLGSRFVFCTKRDQHSQIKSHKGRLVACGDSQRSGIDFDETFAPVAKFTSICALLALAAPHAYHIHQANVNKAYLHSKLDTPLYICVPKGIYMPGKVLQLHRSLYGLRQAGRIWNNKIDSALLALGYVATESDHCVYVWTAGDERHYIALYVDDLLMISPSLPEIERTLQGLEQRYGVKQLGEAEYVLGIQIWRSAEVDWTERGEAIDGDCVRASSLVQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQ39</accession>
    <name>A0A2X0MQ39_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C016g08099 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C016g08099</name>
        <name evidence="3" type="ORF">BQ5605_C016G08099</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY20581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQ39"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009686">
        <property type="entry name" value="Senescence/spartin_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06911">
        <property type="entry name" value="Senescence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Senescence" evidence="2">
        <location>
            <begin position="178"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY20581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="356" mass="37318" checksum="D75D538652C0EC10" modified="2018-09-12" version="1">MIQRRSIVSSLSAGVFVLAGEPHIGALLARSMGASTSLRRAQLIHFDTTDTPFGTTSDPYSYLFKPSLAGTEADAASSATGWIRLTLPSTTDEAFPQSSSHNTSPTDESEPVDEENQTLFLKLRDSFEQALVELGLLTDSMMLSAADDIGQSTRASLGGIAQSIYERTRVRIEGSEAVKPAEEVQLGERTKNFVGGVEGASQGVRDVSNKLTGYIQQGSVWLGKQVVKRIPVGKKGEMEMEEGTEERPDMSTWEKTQTAVGSIASGVADGSTTLASHTSQAAQDAVTHSKGSDAGEVVEKASQTAANIGGTASDVVVKTSVALLGGMASKAAVEADRSADGDGGGDEQGEEEVRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQJ9</accession>
    <name>A0A2X0MQJ9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C026g10206 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C026g10206</name>
        <name evidence="1" type="ORF">BQ5605_C026G10206</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ27849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQJ9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ27849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="312" mass="35651" checksum="E7E4719303F6BCF0" modified="2018-09-12" version="1">MLAKLVPDILGGERLALDHLEIRIVDTLNDQGTGASVLLLQVHDHLGVGDRSIETVHGPPLSQADVGGPHMPMLEDARIALALEVRLDSNRPQLVIILAELGYLDLPRLLSNDPTNFPQQISSRQGEARFVSLYWIAFRSAPTAQQPALEIQPREAIRRSDLRQVESFEPATRGQSKQETYKQFVFNDARLRSLERPALLRQYIAARVLKEYRTRIQDFDDILARIFTVPIDIAAKHEESRLFREILSPLYQECQRPLPEDEIRTDEDPEGSDRLLRWIQKVLWYPGSRRRHFRQTGPDSGCLGIPRETFPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MRN9</accession>
    <name>A0A2X0MRN9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C027g10435 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C027g10435</name>
        <name evidence="3" type="ORF">BQ5605_C027G10435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MRN9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041320">
        <property type="entry name" value="CxC1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18802">
        <property type="entry name" value="CxC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxC1-like cysteine cluster associated with KDZ transposases" evidence="2">
        <location>
            <begin position="207"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ28745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="406" mass="45383" checksum="126E43D4F5CE964B" modified="2018-09-12" version="1">MPTSRLKPRFPRVKPSDYLDHPDCPDQYADVPLVHVHAGHRFVDKGGRKRPRRADAQSSHTASATSGVNTTTNQPVPVTSSSVSTSVFVNDLDFAQGDFDDGQSTGPWEHQDYEYEDQGVMDSSDHFRYSPDPDLQRPTHQEFAEAVLPPPRASDPPLAPKRDGYLITAEAKLRESRRASMIVQDLAFRTRTHGRLRPLVSEDDKDDSAAPSPCNCQHEHAITREMVLYDVTAFYPLAVTFCASEPPCVADVERLAQLGFIASTAARPESAFSFRLIEFAEACWKVSPQAVTGYADGLELYFMRCGWGTKHNHRHPYLAGQSPDGAGRIDCYTMGRSERRLGRWSRRLYRVWRQRGQICAMLHQTTDNDSNPARPPNSTHGKEGSKPVQEARGTQAGCEQKANLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MRW0</accession>
    <name>A0A2X0MRW0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00822 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00822</name>
        <name evidence="2" type="ORF">BQ5605_C001G00822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY49813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MRW0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY49813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="216" mass="24687" checksum="F5CDCD8B8AD2AE1C" modified="2018-09-12" version="1">MVHHCIGLPSSPRAKNQKSCLIARARTSFFGWLNGPADLEVFTLPEQQWNAWWKALRKLRRVHSDAEDTVHLLSPGSLHPGRQLASSTSPHSNNRSSSCGPPRGRLPFCPSSLVCCPRLHTPSVIRIWSYGLSRPSSDYRSYDEHFCDTVFVNFVCPAVSRSERRLVELRVLFFHSIWKLCRRRRFSSDLLEPIIEMDFEGLRASIQESKGRLVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MSL2</accession>
    <name>A0A2X0MSL2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g03908 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g03908</name>
        <name evidence="1" type="ORF">BQ5605_C006G03908</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY54766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MSL2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY54766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="470" mass="53736" checksum="837B197697745FFB" modified="2018-09-12" version="1">MARGLGRLANEIDLLLGILRRAPTIVTHSNAFSDLYQTMGRHKWNRFKFRPDYFEGHPDYNPRGLRSDARLRTNIPGTRHMVTSPSPRPLAPLIQANFDEAANPSRMDWDDERHSEYGGGHERDFSPAPYFPDRTSHMPIAPDYIATAERLSLTDLRQVVSFEPATCGQSKQETYKQHEIALEPHWFRVQTERIKRISRFALGQKRKRGGGSARVLKEYRTRIQAFDNILVRIFTVPIDIAAEHGESHLFREILSPLYQECQRPLPEDEIMTDEDQEGSDRLLRWIQKAYRPFLGKRVPDEYWDQLESEHHTWQAAPRPFATTVLVHIPKPPKPPTNADLEPERKKIWDSWIVECAHRWLALSSKPRDVYRWMRKKGSGGGGAAVGVLEMRVRNGAFVGNLFRSARLYACLASQPLSLQLTDGWITRTSVSYLIASVLPQGTDPHAEKTQHTSNLSGTLPLAGARLNLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MT37</accession>
    <name>A0A2X0MT37_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C006g04088 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C006g04088</name>
        <name evidence="10" type="ORF">BQ5605_C006G04088</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LCL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY55880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MT37"/>
    <dbReference type="STRING" id="796604.A0A2X0MT37"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302">
        <property type="entry name" value="EBNA2 BINDING PROTEIN P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TNase-like" evidence="9">
        <location>
            <begin position="85"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY55880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="256" mass="28606" checksum="97EE1B682F6863A8" modified="2018-09-12" version="1">MRSKELSREAASSAPDPPRPGCSSTAPSALTPTLTSSLLRIDHTNPLLVGASAVGLTLSSYWIWARYLRRVANVEQLTAAHLNGRALRGIVTSVGDADNFRLYHRPCWAFYRRVPTTRAGLKNQTLHVRLAGVDAPELSHFGNPAQAYSAEALDWLTRSVLGRTVYVELYSKDRYGRVVGMAYVRNFPFIFRRNVSEEMLKRGLATVYTQGGAVHAGLLHRFKETEARARRRKVGMWAQAPTEYESPAAYKVRTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MTS5</accession>
    <name>A0A2X0MTS5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C042g12011 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C042g12011</name>
        <name evidence="2" type="ORF">BQ5605_C042G12011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000116">
        <property type="protein sequence ID" value="SGZ31820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MTS5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="701"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="715"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ31820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="746" mass="82065" checksum="C6AE6F6C09D6CA40" modified="2018-09-12" version="1">MPIPTQGMSLNLMSTPSVIGLNSVLSSIAGAAALRGSNVLSQQFEATPQIVVGTAIVDKSPGDKRWNNIPPLKFFTAATVPGPLPDEVVSLIECEPPISPATETGIPDQQSTSSSQPAFHESGWNVALNLDHQGRTGNDSEGCWRSGETLSGFIQLDPIPGVSQKAISSVIVRVYVQSNTVYTAYRFVQTSEPATGLFYKLKTSGAGGVTAINEIKGEWHRAYIDGGSGREIWHGGELEEIQREVEGDFPLLGEEQQRIPILPVARPNEPHSLPFAFTLPNTVQISTSNFLNNRIPGRVELQTYRRTPPPSIPGTQHGAVAVEWIAEVLVRFQDLDEPGEDLAVPPAPIDMNDDDSLPNFEMATFDPASRYSEFGFLSSSPNLQVHRVVFPFEPSDHDAQDLYSFWRPTATGAWSETVARYNGLNLDEIEDDRPVTEGIVPKFGRYPRDEALGGSNMGPKRSMKGKLVDRLGGRDMWTSFEKRMGIKSKLGRLTGWIRVETSVRRPLMLARYSPFLPILLHFSFLPSKEDTTSTPARTLEVSQVVVVLSRRLLLRSGREERPKMSRHSHFHMDEMRREVVDLYDDEIRPTMETITPINTMENALSRSRTMPLNGLKRRGLMLSLGDANGADLRIEFDMQSDGTGTNGKVLTPGKGMGLSCRMPNVELEYIISVTIHPFCQPSFYALRVPVQIIRGDLDDAPPFPVGDSPFPHANGGSTNSDSHSSAPELPAHDDVANSGLPSYETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MTT5</accession>
    <name>A0A2X0MTT5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C002g01537 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C002g01537</name>
        <name evidence="9" type="ORF">BQ5605_C002G01537</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY33743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MTT5"/>
    <dbReference type="STRING" id="796604.A0A2X0MTT5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22927">
        <property type="entry name" value="HFD_SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037782">
        <property type="entry name" value="Spt7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47343">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47343:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="8">
        <location>
            <begin position="117"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="223"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="285"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="418"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="503"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="441"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY33743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="936" mass="101011" checksum="43672B9C14959B8D" modified="2018-09-12" version="1">MPVPVPLSPLGLSPFPSPRSSARVLSAGARRAPLRALRDAMHTHRGRSANRPSSWYLFEAIERRCGNQSSSASSSRVQCSAVELKKLVLDASEGVDDKSSANDFIDTLERIVNEIKNTTEHSAAFLQKVRKTDVPDYYDIIKHPMDLATLAKRVKQQMYRSKKAFAEELDLIWSNCLLYNSHPGHPLRRSAEILRAKSNQLLEFISDPALPTRSLYAQTVATQVGGASSRHRNSVRETPAPGDEADVEGDDGSEAGARARSVSVALGRHSSILQAANERLLNGVNGDARERSSSPISGPQTPLASTFAPRNKLGRGPLGRSPSPMPEPEMPFEERPALIRTAQGMLDFASLDDELSRLDAELERNPVASTSKLIYTNPTSLVAKASKTSLVSEASSHDSAESQSFLYKLVHSLNPAAYPSPPPSIAPTNGDSSSSGATGEASPPSATTTVTSRPNLDEPPDSLWWETVAPSAETATCLHDVDIPSTASFKALAAGMPLVPWRPAPPEAKNGHRVKRRKLAKGHESEGRGENGVAEVPKATTNGKKVSKAKMNGTGQNKNAVPLVGLGRKMHHNTETLRKIRRLHKFLSSGTRTPTSMMEPRAEGDIVLPVAADLSEFDVEDSKRPRGAAYLDSGVPASAFRTAEAPKAARQSMEFVTTRVLEHVGFESSSSIALDVMTHVASEYLSNLGRTMRFFADRFGDKMSTEQLLLHVLSENGVASPSDLHAYVSDDIDKYGATLDGLHGKMDKARRDQIQATEVEATVDESKVFLEDDELAIGTLSTVTGEDFFGLEALGLDKENHGATHLSIPSRLFSGQAEPVQEIEYPPPPLTISAISALPRLLQPYFALRAANPDLGLQEDHTRLLPGLPGFLPRAKISPLTGKISAKGALAQKRKLDELMGVEGLPSPTVTVSASSIDTNFITQATNRKKSRLVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-05-29" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MUG6</accession>
    <name>A0A2X0MUG6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C007g04549 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C007g04549</name>
        <name evidence="5" type="ORF">BQ5605_C007G04549</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAR2 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY61336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MUG6"/>
    <dbReference type="STRING" id="796604.A0A2X0MUG6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13778">
        <property type="entry name" value="Aar2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.550">
        <property type="entry name" value="Aar2, C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007946">
        <property type="entry name" value="AAR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033648">
        <property type="entry name" value="AAR2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038514">
        <property type="entry name" value="AAR2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033647">
        <property type="entry name" value="Aar2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038516">
        <property type="entry name" value="AAR2_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12689">
        <property type="entry name" value="A1 CISTRON SPLICING FACTOR AAR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12689:SF4">
        <property type="entry name" value="PROTEIN AAR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05282">
        <property type="entry name" value="AAR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20981">
        <property type="entry name" value="AAR2_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAR2 N-terminal" evidence="4">
        <location>
            <begin position="7"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="AAR2 C-terminal" evidence="3">
        <location>
            <begin position="206"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY61336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="439" mass="49220" checksum="9BDE5E6F827A8C9E" modified="2018-09-12" version="1">MSPTFSQGVKFLPPGLHCFVFSSVPSLPTPDTDPNSTNAMPSGDPTNGLGLRSGLLRFYHPDRMPETIVKEWDHRASALKPTSATASHPVRRRTINSADATPSPTIVSDEYLKTLDRELAPFEDGWLEQWSRLIDCITEQTLARVIGLDEQGCAIVDATTPSNMDEKELHAAEAKLGKRQWGKQRQETEQDVATTESQDDDERLTFVEFDLKKSWPEGAQGHELSIWSRDKSWAMNEAVQKHLQGDFKSLLGEVQLSFILFTQLHNFSSLPIYTSLLQLISQSSSIYSPDHASSSSSLPMLASYLSILRHQLLSLDDDFLSLHLPSLSTTLTKSLHDLQKNLSDVSQTWLREMGTSAFVVWQEVVNRWDRLTADVMERFGWEVAAIRGSKLMGKDLVEESVGRVPRGMENAQLGWDDDDELEEGEDAPIVVDLDEYDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MUR0</accession>
    <name>A0A2X0MUR0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C069g12858 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C069g12858</name>
        <name evidence="1" type="ORF">BQ5605_C069G12858</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000131">
        <property type="protein sequence ID" value="SGZ35074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MUR0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ35074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="80" mass="8699" checksum="7ED4224CADCB34DC" modified="2018-09-12" version="1">MKTIIAARCVKLAEGYFYFYFLTGAHKLQSFGLAGTATKRAKGGYKATTASSWVKVKPLRAKSAAQIKTRRAPNADSNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MV12</accession>
    <name>A0A2X0MV12_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C007g04749 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C007g04749</name>
        <name evidence="1" type="ORF">BQ5605_C007G04749</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY62888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MV12"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY62888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="49" mass="5450" checksum="D32D6DDCCDF9D631" modified="2018-09-12" version="1">MYQHTVVSAAPACGVHVPIRSHVPALCRLSYFSCRSNEATAFPVFSFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MVR5</accession>
    <name>A0A2X0MVR5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C004g02732 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C004g02732</name>
        <name evidence="3" type="ORF">BQ5605_C004G02732</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY66986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MVR5"/>
    <dbReference type="STRING" id="796604.A0A2X0MVR5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="569"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="597"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="637"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY66986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="660" mass="71023" checksum="A43DE06930C47B08" modified="2018-09-12" version="1">MREKSDNGSMDEKNVTVNAYIAAPADAHPVSLVEYLHWAKLQREIEAEDTTAARACDSRGKRRAVPYVYKCRFADRAMIYSTTPSNSFIPVKTGGLGPLGKVIAKQMEKKGDAPGIDDGAHRRMEGELEQMQGLFDHQTELSNARRLLRQAGWATGFFLITADILGPFNAPFAISTIGLAPGICLYTLFGLAAGFTGFMIWKMFCQLDSVRFPVKSTPCAIVILGNGGGLSQIVQGKLCFTITVLIWAVVGAAISMVRELHMFSVFADFSMWLNVLIMILSMAFVAHSPPNIAGAIAAYGDSIGTRPVAIKAIVGGSLFNQNNGAFNMVFAFGGSMIFSEIIDEMRRPYDAIKGIACAQIFGQYTLPLAYQGVAKYAWQCVGNGIALATVTVAAGLYANVGLKVVYSNIVEGLFKGSSLMTRKGQMIYPHAHRLPFTTPGVAPKRIDSWSNFSRWKRGLLAGGNKRLIFKLFNLVFFIGALGTGGLGMWGTGTALAQTIKAEEMASTTVPPAATSSHPIPSPSSAKTNLSYLVRGPQAGGARPASLTLRTALRSTRYVVKFVFWRLLRYFKYTLIAAGTAALAGTAIGSIVPVAGALLVPSIPVAAAIGLGTAVLKFGWRHRGNHFRQGWLGGEGRDARADERNDAEEAQASKAWTSQSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MXB4</accession>
    <name>A0A2X0MXB4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C005g03274 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C005g03274</name>
        <name evidence="2" type="ORF">BQ5605_C005G03274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY73208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MXB4"/>
    <dbReference type="STRING" id="796604.A0A2X0MXB4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY73208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="420" mass="46408" checksum="E8E169F9E3634777" modified="2018-09-12" version="1">MAQLDKCVACKKAVAPVIAPEAPSTTGLDSSRSLQVCSKCRGVAYCSRECQVGSRVNHQVMARTAISRTPRPLLQIKHWPSHKSQCPILALSNKMSSTTVSPKPKAKSTTPVTNPIADPWSSFKPFLDSISTELCWVLSLPHVPHVHDPIPSTRQVAWYHLHFSLNPSKEVHADPKAGTTTLKNSRRQFVLKLGQRTSPPSFLDWIRSEPSHTDQSQIVQQYQKQLFSLVEADRTVFEKGGKLENQSLRRVICTAEDVNRRFIGLSIQALGSHTVTRSALDPLNEDLDWVGPLSRILETIEPCDGSESSASGKGATKSSSGEEGSTKLLEKIVRELMKDEGWAERSLKSWKEGDKKENELLHAALLKRGIKEQVLVGGRLGKGYYYAVPVSVPNQMLMRTNSSTRGALFGRRGGRIRTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MXR8</accession>
    <name>A0A2X0MXR8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C005g03424 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C005g03424</name>
        <name evidence="2" type="ORF">BQ5605_C005G03424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY75397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MXR8"/>
    <dbReference type="STRING" id="796604.A0A2X0MXR8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="744"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="794"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="968"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1078"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="834"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="868"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="968"/>
            <end position="978"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY75397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1178" mass="126149" checksum="2C6C10A1931B26DA" modified="2018-09-12" version="1">MNPYSRKPSLPTPGESRTASSVSAGGRARSLTAPSSKFALGDDCLPSISDFRASQIFPGFSSTFPFKVSVDADVEGSEPARPTTSIGPKGTFQHRLGTRHPNGHLRACSDSPATSPDFRASQERGSHLEWRGPASPDDSGRTQKPSARAPTVMDRARYETAQSFTPGPASVQTSSFRSRTFAHDRTGDCINQLSQHDTAEPTSRSFGQAPTDATALPPSTVPNFLGDTSLEAAFADTSWSFDMGALDIGTFLAGPSALKEDGDPQNGEEESVPVGSSYHEKAGVRASKLAPGQGLDLDAPSCKHGSLDLDRPSSKHGKWTRPDSQSVAPILDISAYRRAGLDEPVPSSVQEMEHLAVSLRPTSQHHPDETLSITTNSTSTAANTIADGAFDQIDVTIDDIILIQNSLVRAASLRLRTETVEPDLFPASGALDAAANEFVYSASSEGPFNPAWDELSRPAPAQHDMLDVVAEAVPHSLNAAGSALQTQPQLGIVVPPTASRSIFVEHEISSKPSNQLKEQPSGAIVRAPEPKHRNLSVAVPPRILKYQIDHEGDDPNSDDDEPLAHRVNPQGARATDGADGEVAGVIASGPNVGLKPSRDSLLIRDVRDRATLATLALKQGQEGRQEYKSVRKTFISGPTLMPDPISMTVVPIRNPDAALTQSFGSAKQSYQPLRSSSQPRKIKELGTRFKSILKKKSRDCVALLNGDEVTPFQEHEQDSHDALDYRTDDDDDTTVTLVEAEALADRRNQRGTQPRGSFYALKPASRSSRSLVNLVGKLRSRSKSEGLVRSFEGPTHLATIPGSPYCAVEPVEPGTPQGPEAAPEPHGRAPISYDINSRRPQQYYSSEPHASATMPVPADDEPSHARSLSEVSSSYGEDSSISSNQGKAPPYTHLHDETDALYGSAVEAPAPTRGESKRVASMADGASPLGDWADADYMLGILENDAGGSPMTSRCDASSEHRDSIVTSIHARSSNSSHVDIKSRDSATPEASAHSTRSCTSAIAAEDLPCFTVSEEVDTYYSSSEAAAVGGGHLNKAPQSPMTLAAPLTGVDYRNSGYADSFYDLYAQRSADRATFTTDIHGDPIVGKNGQQSNSDDDSSDPTSSLPDRNSPMVKNHNNSTFWKMVGDLRHSRQSMDSIDHDQFNFDSRPPSMIGSDMAESIMDTDLENARLAFDEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MZQ0</accession>
    <name>A0A2X0MZQ0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">BQ5605_C008g05295 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C008g05295</name>
        <name evidence="13" type="ORF">BQ5605_C008G05295</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY80056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MZQ0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF139">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="563"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="607"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="660"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="703"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="843"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="867"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="11">
        <location>
            <begin position="69"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="12">
        <location>
            <begin position="310"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="10">
        <location>
            <begin position="558"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="274"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="965"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1020"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1206"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1246"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1386"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="281"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="974"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1206"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1246"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1260"/>
            <end position="1291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGY80056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1430" mass="160220" checksum="2FA3FC70D0EB0120" modified="2018-09-12" version="1">MATLKERNYISTFAGLKGTAITAGSFLVVGFTMNEVLKRLRRYPDEDRRRAKGEKVRDRGVEAYAMGYLYRARSFVPHLPTPDFGTRPWAWIYSTSYKLPEKFYEVHCGADATTYLRFLRGTFYWTLLLTCTIFPLLLSIHFIESDATVSTASIDRASLTSLVLKPNGTRLLWVHVICIWLMTFSWYAVLGWIGYGTVRIRRNNLRRLLRDEADFLAKGHTGSAFAGSEPRPMNPDDERPVGWRWRTILMRNIPPAMRSDEAIREYFESALRYDGGPSSSDVDKSEGKEAEAIEMKSSRRALPPTTPRFSSSAHPRLISDIILVRKQNELNELYVKLRAVQHELESAHTELAQNVMKFVTAKVQEQRRRDEGLPVKKSFWRRLFKQKKATVDEDLESVARQGDHKIIDALRKFLGDPDQPLDYGEPGAFWIALNALHSSDITLLDRFQPLVQLKHFYNGQKVPSIDYHLAKMNLLTRLIEEIRANPEQIEVASSAFITFESATDARRARKELKPRMHGRHRFGQQALACKIEIAPEKRDLDWNKLVNISLSGDILRGFLLQTAIWAATIIWVIPVSFVVGLLSLSSISKYIPKLAKVLEGNTVTQSLFQSLLPTSIVALLGMLVPTLIGIITRNGQALITTTRVHSAVQARYWKWSMTNITFASQILLFCIGLTAFNAFLNAFKQPTSVLTVVASSFPKGATFFVSWTLLVVGVHHGIEIALFGIPWINHASIRKYKAPRKRALENEPRFFNYAYWMPNHLIVFAVTAIFACLNPLVIAFNMFYQLFEMIVFKSQVSDHRLRRTAPTLDTELIADPVSQVSHVYWRRWYENGGRYIYRRLFRYSLDVFLVAQAIIMAFMFVTRKPKYGGAVIPLLPVTVIVKLIGTRWFDALLDEIDEAEIDIVCCDDAQIIEDLSVPLTDFDHNMHNLSLGEAYGTIKAFTTSTLPALALRPHEKLPVIPSPAKSAEHLRSRAGSTSTAQSPTAGHTNHRHHHLRPSLDDDVPLTQVEMLRTPTPTTADLTVTDVFGPKSSPPSARDTFDLKRFAQGDHGSRVPRPEFVDDTKLIALHPPLMRDDRPVTNVRYDNPAQVAPLDRSLWLPSNPLIPVDLGDTIDYYGRALVSSEGGDGLIGRWDDDEHLNDETAIVAADGQAVTTPGGEGNGFLSVLKRSSSRTSGSTKSRPVLSGNERIRVASDVALRIEAEETSISVVSSERPRNSSIGSASGSMMPSMHRNLVSEANQIQIVTSPSPVGTSPTEEFGQGSPGPRQGSSPSMLHSPASNLSSASPATPLQDDAQVQEDGTHLTVTPRRPNKLNLGDSAPFRVRDRSNSGHSGPRTPRYASRTRNARSPSVAPSGISIAEEVEGHSGVVVISQSIALIEEVLEEERKEHEERKEKEQKRHAQESQDRKLGWFSKLLLKYGEDEDEAKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N0Y6</accession>
    <name>A0A2X0N0Y6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C009g05746 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C009g05746</name>
        <name evidence="3" type="ORF">BQ5605_C009G05746</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY85222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N0Y6"/>
    <dbReference type="STRING" id="796604.A0A2X0N0Y6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990247">
        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF3">
        <property type="entry name" value="YTH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YTH" evidence="2">
        <location>
            <begin position="766"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="domain" description="YTH" evidence="2">
        <location>
            <begin position="964"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="709"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="831"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="438"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="848"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="864"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="887"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="907"/>
            <end position="924"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY85222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1128" mass="122254" checksum="8BD88334672EB178" modified="2018-09-12" version="1">MTGTEPALQVDSTNSTGIITARALSKSDPPRPSSQVVSTTPPKTSSAPTPVRYSPANKAATTTTTIARAHEIAPTSGTSPTGSGEGKRQSSLGERARGHLQQQNTKQQRSGVVGSNSRDRTKHKGESISLPSRTSPTRQAASNARSTPGSGRSSSSRNLLINTSATSRHPGSGDDSSMSSNPVCRGQSDLSTSSPATTATNPSSLSSHNAQNYSVSGMREDERYANPHSGFSERPHASTSRSFVSPSSPRMMSYAAPQGHGHYPPVSPKSQNPPQIYTNGQQTYVLDSSGQYRPESLGQAWSPGYPPPQQYHVQYVPQYSTASPVMTSHGQMYSPAISSAPFMYPRSSDRHHSISEHYTGMTYAYPNERTTPMSEGLSMFSQPQYSGHDRRPSNTFSDGSSYGHGNRSYHSTEMSTGSPYTTAGYSAVPAYPYYPQQQQYSHQQQFAPQRYGPQHQQPQQTHIQMQQHHPNRPFHTYNMSGPLSPTMSYSGGYEQQSAQPHASDYSSFYISGEPQVYVPPIEVARGQLAQSRLHDAIYSRETKYSSRSPAAAMTTPIGAHGGLAMPKPPAHSPHALWVGNVPADTTHAELWRFFAGRPPPGASSPSSSSNASVVEGDVDLRSNGIESIHLIARSNCAFVNYASDVHLQHAIAVSNDIPLRPHDPRPKNLVCRVRKKEDDAKSGVGAQRIGGMHHAFVAARKHEETRVVKEAADSARETTSGSGQEEEDGRIRSNGETRVASISSVGGNSFSSTSTSSSYLARHFKKRYFILKSHDENDLHLSVERSLWATQSHNEPILHQAFNTATDVFLIFSANKSGCFFGYARMTSGISNDPKKRVSWSSREPSPNSKDSQDSSLDSSNLKESLNPNASKGSHASMMPRSSAILEENEDNDEPLEEKEEVEEAANGSQSPAAETSNGVNSKTLPILFSPSENRWLDRSPLSLSPAGGPTSESAPATLAPETKEAFVVGSTTLDPNQLRLPRLVIDDEAEPNTEFKARSAPVRTHRAVLTQQLLGGSDAPSTLGADGVRRKDMVISPLEKSERMGKLGVSLSPIETIEAALPESHEDSLGWGRPFSVKWLKVSTLPFSRCKHIRNEFNGNREVKISRDGTEVEPSAGAALIEQFDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N1I1</accession>
    <name>A0A2X0N1I1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C007g04561 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C007g04561</name>
        <name evidence="2" type="ORF">BQ5605_C007G04561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY61464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N1I1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY61464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="112" mass="11967" checksum="5F1B6B96E8AADA03" modified="2018-09-12" version="1">MCGCGEDGTAGNETWAGGEASNDKAGTPGAALGTGAVGPVIVGGCRTLGPLWPDKCTRRGHERNVKRRDNFAKNSSGDLTRRGRSSQACYEYGTRRHAKKRALDPSNRQRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N4R5</accession>
    <name>A0A2X0N4R5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Delta(14)-sterol reductase</fullName>
            <ecNumber evidence="3">1.3.1.70</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">C-14 sterol reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Sterol C14-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">BQ5605_C028g10514</name>
        <name evidence="21" type="ORF">BQ5605_C028G10514</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="17">Steroid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.70" evidence="3"/>
    <dbReference type="EMBL" id="FQNC01000080">
        <property type="protein sequence ID" value="SGZ12575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N4R5"/>
    <dbReference type="STRING" id="796604.A0A2X0N4R5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050613">
        <property type="term" value="F:Delta14-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000011">
        <property type="entry name" value="Delta(14)-sterol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF52">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE TM7SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="443"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00069705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="SGZ12575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="502" mass="56280" checksum="A55ED38DEBE9F297" modified="2018-09-12" version="1">MVATRSSSAASTPNKAAATSLTPKPPSSGSPSATGYEPAPRSTSYEFGGPIGALGVTLAVPFFAYWLTFACTAQQCPSWPMSSFLDFHGQGFQRMTTSQFYRDLFSKEASIAYGLWYLWTVVCWAVLPGDQVQGVELRDGSRLTYTLNAFATMVLTLVLVATVTYTQGLKPLLFIVENYVQLISAAILMSVVQALFVHVQSHQKEVSETLGAPRGYLKQPMLALGGNTDSGFYNWFIGRGLNPRIGSFDIKSFNELRPGMILWIVIDLAMIAYQYHTIGRVTDSILLVVAFHSCYVFDALYYEAAILTTMDITTDGFGFMLSVGDLLWVPFTYSTSTRYLALHPNDLGPVKTVLIIGLQFLGYWIFRSSNSEKYEFRKGNNPKSECTSPVGSFVQKPDTMRSVVVCAPDLSFLQTERGTKLLTSGWWGLSRHPNYMGDWFMSWAWSLPSGFSSLVPYFYVIFFAILLIHRGMRDDEACAHKYKKDWETYKEIVKWRIIPYVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N5C5</accession>
    <name>A0A2X0N5C5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BQ5605_C029g10715</name>
        <name evidence="16" type="ORF">BQ5605_C029G10715</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="2"/>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ15968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000007">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08284">
        <property type="entry name" value="RVP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="11" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="15">
        <location>
            <begin position="1087"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="14">
        <location>
            <begin position="1380"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SGZ15968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1435" mass="161704" checksum="75D91A553AA9C9B9" modified="2018-09-12" version="1">MARAKKATAQPPPAFQPDKPGSSDDEEETVTMPKGLKLNAPKLASDTTLTLASVRAYLNDMDNLFTQYKVTSMRFKVMFITHHIEQEWLKDWCGSATEDCTWDEFKVAFLCKALPLDFAYTTEKAIQHSKQRLTDYTSWASGLWASQLQLGQAAFSDTSFIKVLLFNMDPQLSVILRQDDLLLNTGMHTDNLDYVVTSKTALPKPKTISYEAFERLARSKWNMITALCVVAAPRTHNSTMATRTSLYRPPATTSTGGRRLPAKLTDAMKDYLSLKEGCSSCRQIHTDHRSKDCTAEWQKAPDVPEGWTEFEKRKASAAKNDTLHQMAEQSEDDLSTDEENEYAPQFISTIPITLHNGKGSQTLHALADSGASSSFIADKVVEKLGLAVHRLPVPTMVKTAIKGQKRAFHVTSYVKIPIALENGTWEAGDTILKVAKLQEPLEVVLGFNFLAKHKFNINFARHEILVPHPSMPNVMIDLLAPVFGPQPQRAVPRSPKRSDKARINWGAVIAYIDGVQQKESELAELRAREARLRVEFADRFPGDIPPVSMYESPVRHRIELKPGAKKPNLKGYQASHRYRAPWKRLIDQHVTAGRLRKSSSEFASPAFVIPKKGMDKDPSIQPRMILLICSKARFWGKIDMTNSFFQTKMAEEDIPKTAVITPWGLFEWTVMPMGLCNAPATHQHRVNEALGDLIGNVCFVYLDDITIFADTLEEHKRRVRLVLDALRRADLYVSPKKTELFAAECFFLGHQITREGIKVDPDKYLRKFIDKLADLTAVLVPLTRKGAHVDDGWTGEHNTVFEAIKALVGSLPSLHPIDHSEQGDPLWLMTDASNRGIGAALSQGKEWQTAMPAGYWSWQYNPAEGNYAAHEMELLAIVEGLHHWRADLLGVWFKILTDHHSLAGFMKQPSLLRRQARWTERLADYDFEIVYVRGPENTVADALSHYSFPEDCATRGASDDVNMLAEATLDPAFLKALKDGYLNDTHCQQAIKNIDSTPGYSYKDGIARFEGRIFLPKTGDFRKNAIHDAHDATGHFGLHKTYERLRRDFIWSGMKELCKEYVESCSVCQTMKMHGTGFAGRIHNLNVPDRPMREVGLDFVGPLIPINGNDALLTVTDCLSGYVRIIPCRTTDDTTTTANRFFDGWHQYFGMPRVLVSDCDKLFTSEFWHAYTGRMGTKLAMSTAFHPQTDGQSKQTNRTVIQVLCTMVNHRQNDWSKHLATVEFVINSSVNRSTGKTPFEVVLGFTPELTPIAPVYGSTISQAVESIMEQRETAVSEARDTLAIAKIRQADQSNKVRKLEPEFAVGDRVLFFPRFDGPYEVLAACPETSNYKLKLNAGDKSHNVFHASKLRHWTDNDGAAFPGREATEPASVVVQGNEEWEVDRIVDEKGKGKRKRYLVKWKGWADSDNTWEPRAHLEETIALEEWERERAEGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N684</accession>
    <name>A0A2X0N684_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C008g05147 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C008g05147</name>
        <name evidence="3" type="ORF">BQ5605_C008G05147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N684"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="341"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY79491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="539" mass="59826" checksum="FFCABDAA6CE8BF5A" modified="2018-09-12" version="1">MVPTLPAFDRHATCWHDGDERVAIRVCLDSERADAISARFNRATSDSQGLAAETSRQIENRIDLIQDSIHTIATIYSEDRRRAEQRHQESQEALHMLQMNNQSLYAGMAGVQMTSQAQFGVFSANQVLSDLRMQLFSHPKNSQEYYDIKEEIEVAKQAVKEAQLMYQQTLQQSNLAIQNANPIFHQQRLANNASTPTEANTTNNSPTRERDEPGGSPSKRGRLTHHARGVDGEGSLVSSVMGTERRVEEGMSIVSTQTKFPFSSRTLSDEVLLMAAGPINEDIEPRKQNHIHFLHTLSTYFLLAITINFHSISAPTRSIILLLILVLDKNRVNAATPISIASLNVNGLADPVKLQQVQQTLINSEYHVVSLNELKFRTDTRLPVDLADFQPILTPSVRAGSGMKWGTLLLVRNNLPILKSFIFTEGPLVGRVAAADILVRTREGTDMVPIRIVSAYCPHGGYARNTENDDNAITGFWTAMQDLIRTGPPNWAVVGDFNAVLDARETAATNLLEPKAEARDTFSTRAEDDSKDSSVLQSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N7J4</accession>
    <name>A0A2X0N7J4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">BQ5605_C009g05668 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C009g05668</name>
        <name evidence="14" type="ORF">BQ5605_C009G05668</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal Na(+)/H(+) exchanger family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY83985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N7J4"/>
    <dbReference type="STRING" id="796604.A0A2X0N7J4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF4">
        <property type="entry name" value="NA(+)_H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="280"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="437"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="13">
        <location>
            <begin position="53"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="514"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="740"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="802"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="535"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="574"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="612"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="693"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="742"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="802"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="931"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="942"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="978"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="993"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1050"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1078"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1113"/>
            <end position="1133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGY83985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1133" mass="123761" checksum="909177930DA43ED6" modified="2018-09-12" version="1">MTKFAPAHGDPSNITSFQGAGTAEEAEHELYQIVPEVNIVHLAITLLSIFVTFFGLFSGFVKERLFVGEAIIATGFGVAFSGYGAGVFAPRSWSFGHHFDDLTLELTRIVIALSVFAVGVELPKAYILRHWKSLSMLLGPIMLLGWMVSAALMFAIIPGLEFLPALVIAAGVTPTDPILASSVVGKGKFAQEHVPAHIRHILQAESGCNDGAAFPFLYLALFLLLRGHHTIGQSIGWWALLVLLYQIVLGCIIGAAVGIAARKLLKFSKRRELIDRESMVAMYVALALLVTGLTTLAGSDDLLAAFACGTAFAWDDWFTESIEESNFSSTIDLLANCAIFIYLGATMPFAAWSDEMLTLTVWRLVLLSLGILTLRRLPAIFALQWWIPDIKTRREALFAGHFGPMGVGAIFISTLAAAKLPTPTVPPENSLDLLALIIQPVTYFIVLSSILIHGLTISFFTLGRRVHSRVASFSRTLTSASRDSRGGLSRNGPVMAEEPAWMSRVKRAQQGEDIIINRDDDLEPTSMAEKGLGGSSSSEYGSNSLEKVTVGDGSDPEDGRGDVSRMRLASMENDLERGEVDGERRRSLEDESHGISLDEDDLTGTARTKKKMERENDDHPRKNILEHVSNDGSRSGSRGASLDRSDRGRPQSAERPQGAEVGRSSEAVAGNRRGSLSFGSRKDSKSPSRPPLRQKDSAREARYCSKNVTQTWQQGRKIIIDRNDGAEVEVIDLDATPDALEESARNDRHEILTVPQGAIDREKEKTPVGDQTPQQHEESAVQRVAQAMLRSRSMLAKLYKEEPNLSAEEKERRRKEKLEKDAWCRKEQHYPEMPAAKRRETQEWPEGEKVVVEHTDGTVDVRDMTEEEKNRRITKHLGALRALGHPIEAFEGRGKRRSPAPAASPSLRVEEEEHDPSALWGRPIQSPDLASSSNSSPRNRNGQQHSSNSPARSETPPPVARKSNTGFALERTGRVDPDSEEEAASEDEDDGRDDDRTATMTRERPESNSKSGGAFKSVKGIFGLGSSKRSASPPPERRPVITRIDVAPALPRPPSPPPPPSRDDPVSSKMAFLRSPGHSPTTPISASTIRFADASRPTRDGAGPSSGLKPLPTTGNSSALRRTPMQGSSKGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N7U3</accession>
    <name>A0A2X0N7U3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C009g05768 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C009g05768</name>
        <name evidence="7" type="ORF">BQ5605_C009G05768</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY85662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N7U3"/>
    <dbReference type="STRING" id="796604.A0A2X0N7U3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF48">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G01000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY85662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="424" mass="47528" checksum="6066512ED29A816F" modified="2018-09-12" version="1">MSLDPTFSDNQERYDFSCIIPHLLLHSHLEHWPEHRILCQQIGGGAASRSPIADQDRTDTLSADSGSSRVSILPETAIIIPVRIVYYLSRWYRKDELCFRLALFSVFAPLSGAFGGLFASGLLEVKPFGAIHYWRMRPVQNQSLNTFCDLLQWLNAEEKVLCAARSKSENVGAIEVVDSLKKEVFFAGMFNTTSVIITLTAFFVTIPILCLEFFLPTIVKTIFPNKGVIALQLRTVPPWILGAVMALILLYLSWKTKRRAVYIVIASPLTAIGYLMFTLSSSPHVRYAACFLITAGATPFLSLATTWTTINTTSDTARAGAIALFVFGANTGGLVATWIYLPHFFFFFYFFIFFLIRARNLPGNILCLVSSLMVLILTLGLWKYHLLENARRDAARDDALLEEGMSDKAVARLGQKHPGFRFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N8X8</accession>
    <name>A0A2X0N8X8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C036g11479 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C036g11479</name>
        <name evidence="9" type="ORF">BQ5605_C036G11479</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000063">
        <property type="protein sequence ID" value="SGY95212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N8X8"/>
    <dbReference type="STRING" id="796604.A0A2X0N8X8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF18">
        <property type="entry name" value="RETROTRANSPOSON, UNCLASSIFIED-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="8">
        <location>
            <begin position="284"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY95212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="870" mass="94167" checksum="7FD9D658451B5249" modified="2018-09-12" version="1">MLECTVPSTELSRRRVAVLAKHNISIGAADAMALVAEYGPDPSVDDDSYENYFAEVALDTEVSALYLHDGPRYLLDLRATRHMTTRRDLLVDFQPFTTERVRVVGAFKSSAMAVGKGTLRFDANGAPLELRDVLLVPGLSAELVSLASLMKDGYQLSGICDAAGEHSGLTVSGPASSLTVSGPASSLTFALDRNHYVLQASPASPPLANHQALTATSLPTDVVLWHQRLGHLSWGRLVELAKSGDISLDISAATRYRLRLLDQCDACCSGKAVSAPSREAAHHPADAPFARVFADVWGPSPVPALSGVRYLCGITDEYSRFRWARGIRLKSEASSVLKGFVAMSKIQYAGPGVATLRTDRGGEFVNNDLRDWLAERGIFHELSTAYEHGQMGIQERSWRTIFNSVWAWLHRSGLPSSLWEEAAQAAIYVINLLPSSPLQQRTPDAVLHAAASPVTSTRRPRIDRVKTWGCAAQVPFAPEQRSNKLAPRSRLCYFVGYSLRSKAWRFYDPVGNKVFESSQAKFFEDCFFPAAANPVPTVVAPAILSYPSVPRRVPPPDLPLDDDNTVNPAGVAPAVAAAPAVAPAVAAPPAAGPVDVAAPPVPPSLVFSNPGPANAPPVGDRSTRARRPPDYLGFARAAHDLEFAAHASVSIEDFDEDDPDVQLYSYEEATAFLAKVDKDNTPSVRAALAGPFRDYWLAAMATEEGALAAKQTFSKPLCPPCGAIIIGSMWVFMVKRNAEGKIVKYKARLVARGDMQRRRGEQIDSFSPTGRAASHRLLLALAVENEWETRQFDVSSAYLNGNLGGTEIYMRLPSGQVVRLQRALYGLVQAGASSYLYDLAPRSLPLASTCFHEFLSLSLGFPATINRASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N966</accession>
    <name>A0A2X0N966_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C026g10249 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C026g10249</name>
        <name evidence="1" type="ORF">BQ5605_C026G10249</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ28009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N966"/>
    <dbReference type="STRING" id="796604.A0A2X0N966"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ28009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="638" mass="71214" checksum="08D728FE57F58793" modified="2018-09-12" version="1">MQLLSRFFRKRSTDNTDDRMKQLAKLSGARLQQAKVIPSSDDTAVQILIDLWHFFDRIYVSKKHGAAKAFARAFSDAVFIPNAGDRLLMEARLAKLGMTWEEAVRSPVWNKKLWRRVRRWIPPPSILEPLVREVFEKFGPLIDAKSKQPLFNKAAHEAAKRCLEAIRKGQVSDPVGIELYTDLGPCGGPDGKADDGVRLYSCQRGTNSLEGGIHRNLRQRFPKSGVSPCHANACLADYVLVHNLTVSPTSPSRFEEAATFLTHYPLYLQVGTFNCTGKPFVGHYNLWLTVELHRLRRKTSAFLPRHSTTVSDIVNPLLYTPSTETFGIVPVQSPTAQTRFLIEPYHVERGTLRLEPVKWSPRNLLQNNTSAIQHMQSRLLTDRKLCHDWLAERQGTRFAVLHVHTPSKRALYRYLSSKIRLGAPQNLRILEITKLWNKYANGVDIFYNMPEHINTWASRWLSLANAQATMNMGGNNVRVIQALLTDPSRGRDVSMLAAKPLLGHKPPVLGRLTEIEVDASDPPTSSIHPFVATASSDTGSSADLGTSSALTRAGTTKGARHCRFCGQTTCQLKGSKLSDDGSVTGCEGACLDCGKPFGLTDEMDPNNPQSQRFCRGLTRAEMNGRAQHQKKCHNFVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NAG1</accession>
    <name>A0A2X0NAG1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C050g12474 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C050g12474</name>
        <name evidence="3" type="ORF">BQ5605_C050G12474</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000097">
        <property type="protein sequence ID" value="SGZ29676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NAG1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ29676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="168" mass="18618" checksum="BA10BB899C64EED2" modified="2018-09-12" version="1">MAKSHDVDSGSLIWNLIKLFLTLALFGGLAYTVKLVVAAWNSAVRILKLELRGNCGRTLWRVRIPRGGLLIRIWVLDFPFSSTKDSLAHQGVSISSKGVAVKTEKRQVTAEETADKMRNGIMKGWEASTFKVPSSLAHSSNLAGSTHDKQKTEYEAKYGPKKHKNHVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NBS9</accession>
    <name>A0A2X0NBS9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C045g12218 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C045g12218</name>
        <name evidence="3" type="ORF">BQ5605_C045G12218</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000115">
        <property type="protein sequence ID" value="SGZ31629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NBS9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD/DEAH-box helicase" evidence="2">
        <location>
            <begin position="89"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ31629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="197" mass="21873" checksum="6F321FFF178E16E6" modified="2018-09-12" version="1">MSHVGTTPRPVRGPPRRHPSIEFRASPLRSASRASPTTPAPNHSAKPTTVLGHWRPRLTQEDRRDSSELRKKIKVILGESLDEDSTPRPVQIEAIAALFDLDQFGNRDRYDAVFVTAPTGSGKSVIFEAMYLIYGRRAVTIVVSPLKGLSNHRAADLNRKGKKAVVVSEEAWRDGELYRQLDDPNHTISFILIVCAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0ND87</accession>
    <name>A0A2X0ND87_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C021g09394 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C021g09394</name>
        <name evidence="6" type="ORF">BQ5605_C021G09394</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000083">
        <property type="protein sequence ID" value="SGZ21638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0ND87"/>
    <dbReference type="STRING" id="796604.A0A2X0ND87"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007811">
        <property type="entry name" value="RPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05132">
        <property type="entry name" value="RNA_pol_Rpc4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="390"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="523"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="229"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="279"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="319"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGZ21638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="544" mass="59552" checksum="F9E8334D02F66CDD" modified="2018-09-12" version="1">MSERKGRGRGRRSVIDTSDSTPAATASPIASSSKQPKIEDNDEDAVMFEDPPEDVEMQAAEDAGDGVPSTGAEASTSSSKRISSTTTSSTTRANPRVRPVGGLLGGQSEYVQDASRSVTPKLKFKPKNTRKNRPAVSDDEDDEVKMEEFDNSRSRGRGRGRGRGRGAMAPRRELEMTASGPMAQGPGGARTTLTAKGFGSKRTFGAAGAGVMNASRDGTQLSGRRNDATDDDDEDDVAEDEDDGSHNDGGRQNGGMLPSSRELDSIGREDEMAPLTLPRDPRVEKLAAERRKERQLRKAKAEREAEMDVKAEPGDDSRASSIYLSSATVTPGLETDSKANSKTTLLEEEKEESKPINPEDTDLRPFFDIKTGEPDQLHIMQFPRVFPKFVRADGTSPPENKDDKSDIQPPEWGRAGTRKEKAARYSKEAGRIGEMRIHRNGKVTFKINNDLIYEVLPAAQPTFLQEIAMIDHPDLNDPPSPTDADQRPIPSVVILGQTYNKFIAAPEASYLLGRIVEQEREEKEAEMKLKAVKRESKAHQDARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NI97</accession>
    <name>A0A2X0NI97_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BQ5605_C043g12067 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C043g12067</name>
        <name evidence="12" type="ORF">BQ5605_C043G12067</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000117">
        <property type="protein sequence ID" value="SGZ32082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NI97"/>
    <dbReference type="STRING" id="796604.A0A2X0NI97"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="11">
        <location>
            <begin position="508"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="10">
        <location>
            <begin position="820"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGZ32082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="872" mass="98070" checksum="7AB6685D44821225" modified="2018-09-12" version="1">MTGSHLLDNENEDKDGPDATPSKSLGEHPSGIGGTGGDHSTEGHSTDGKELRQMTLQKLVEKVNEFTELRRKAQENLDLAMAGIEGLSTTVSTPWGLYEWTVMPMGLCNAPATHQQRVKEALQGLLGTICFVYLDDITIFADTLEEHEARVRQVMEALRCAELYCSPTKTNLATAECSFLGHIINRAGVHADPKKIQRIEDWSLPKTVKELRGFLGLVQYLRKFIPGLAEHTAALTPLTRQGLSSIATLWTPNEVRHFKAIKAIVTSLDCLRPPDHSANAAPFWVMTDASNHGIGGVLLQGQEWKMAPHCELLAIVEALKEWRIDLLGGHFHIPTDHSTFEHFQTQRTVLSRRQARWLDTLAEFDYDLRRYSFTDPLSTLVASVSHVKLSDAVKQHILDAYETDSFCQQAMANIGSVTSDFKIVDALLYLRGRLIIPSLAPLRESILHDAHDAQGHLGDMKTYRTVQQAYFWPNMSREVKHYVQQCDSCQRTKARTTRIAGKLHSLPVPARPMADIAINFVGPLPANKGFDRMLTITDRLSGYVRLLPAREADTAAEVAARFHEGWHRLFGLPQSIVSDRDKLFTSKFWTALHKRLNIKLQLSSAFHPETDGRSEKTNKTAFQILRALVNKEQSNWAECLAVCEYAINSSLNVATGKTPFELVFGYTPSLAPLARVNGDDDLPSVEELLALRFQACEDARDQLAISKVRQAAQSNKRRRDEPSWAVGDLVLLNSSDRRKRLHTHKRRAAKLMDRFDGPYRIVKAHPEISSYTLQLNGDDAAVPFFHTGKLKTYCKNDTALFPNREPVRLGPVDVGGEPEYIIEDIVDERIRAGKQQYLVLWVSWPSDSDSWEPAEALEDTEALDRWERRNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NJ37</accession>
    <name>A0A2X0NJ37_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C019g08810 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">BQ5605_C065g12806 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C065g12806</name>
        <name evidence="1" type="synonym">BQ5605_C019g08810</name>
        <name evidence="1" type="ORF">BQ5605_C019G08810</name>
        <name evidence="2" type="ORF">BQ5605_C065G12806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY22515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000133">
        <property type="protein sequence ID" value="SGZ35231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NJ37"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY22515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ35231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="81" mass="9391" checksum="5E2DC597912328D7" modified="2018-09-12" version="1">MEHRQYRTLPLHETLWISPPPVFIVQHDTSQPRWPTKSLALCASQCDWPACYNSPARLPDRTVSIPCLLMPFFLFSTASQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NUA2</accession>
    <name>A0A2X0NUA2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C018g08581 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C018g08581</name>
        <name evidence="5" type="ORF">BQ5605_C018G08581</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY25102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NUA2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="463"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="499"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="528"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY25102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="562" mass="59762" checksum="673C9F9A6E1EF6B2" modified="2018-09-12" version="1">MKRPASSQVAPAEQSRSAPTGTHTPQVCICGPSSDVATNERPRNDLEPPPQVEQQQHQELRRTESNADRVPAGPMPCRHCGGANRAAAQLKPSPAAAAAAQSRGTDSEKSALERTTSSTSDVEKGREFPSVDTPPGPQAIIFPDGGWRAWLVVAGAWCVSFTTWGYTNAFGVSVSWYEKHQLEGRPPSDIAWIGSTQLALVLACAVISGKAFDAGYIKYLLVLGTCIYTVGLFGLSYATTYVQIFLAQGIACGMAAGILFLPAVSAVSHFFRVRRATALGVLATGSSVGGVVYPLLLNHIFPTIGFGPAIRAAGYLTVGLLVVACLTINSRLPPRKTGPIIDFSHFRDPAYSAFVVGECLIMWGLYIPYFYIQSYSSAHGVHPQISLYSLSFLNAASLFGRIIPNWLADIYGPFTILIVSPLRPPPATGRSPRILSIPRQPNCLLSGIICFAWLALAKTNAGTVVFCLAYGFSSGAYVSMMPACVASMTTDMSTIGIRIAMAFLAVSLFALTGTPIAGAMVARENGSYVGATIFSGVMIIAGTCVNGVTWSLMSKRKGTRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NUC3</accession>
    <name>A0A2X0NUC3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C018g08601 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C018g08601</name>
        <name evidence="6" type="ORF">BQ5605_C018G08601</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY25323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NUC3"/>
    <dbReference type="STRING" id="796604.A0A2X0NUC3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047867">
        <property type="entry name" value="Ribosomal_uL22_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="CHLOROPLAST 50S RIBOSOMAL PROTEIN L22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL22M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="230"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY25323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="275" mass="30592" checksum="E25A966928442893" modified="2018-09-12" version="1">MVAPRPSTSFVATLTRRIMPQPTTRPFHFPSPTPHYPTTSLEFTHQRRSILSVAAFKNLLSRRRQSENDVSEAQSNNLAKSLDKEVAVKSSAPKGLFDTVAEEEEVVESVKVARGQVGRATYHKSSTANFKTSKRKLNDLSRLIAGRGADEAILQLQMSPKKQAPRLLSMLALARDHAMAKGLSRDQLVVAQSWTSKGPSLKRVDIKGRGRFGTKHHNSAKLHVLLAEGMTEEEKRRQRKKDQWRKSIRGLTEGDAGVGNGGRPLINVGVGDWRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NWD4</accession>
    <name>A0A2X0NWD4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C002g01464 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C002g01464</name>
        <name evidence="3" type="ORF">BQ5605_C002G01464</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY33196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NWD4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="334"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY33196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="441" mass="47852" checksum="3DB89626C7A1B7EB" modified="2018-09-12" version="1">MGAYCALAMMDRHSMNYSQTGTIRYTLAHLTWRWTIISAMTSAIGVAGTLTRRAPLLRIFAVGTSFDLVCTIVLLLVFLLVTFSPTLAEPFSSFLCSALTSGEFASVSTLKLWESESQVGPEGFGIELLNFGIEACEEHWRGGMVALILGAIIAVALRTLGTIVTWDYHSTLVKQKLWLQEIENGEPLGLRKEQGWYDAESITSSSAFKGLRGGQSDEESGRRKRSPTTEGRYAAHRERRRSSFPSTSTRPTRANTLPVMFAQQGSGIASSSSPSSRHRLVFVPVYLDRNTTAVAEPLPRYSSSVQLQHITSASAISDSAHSTVSAHRTPESSPPSSRTSSRNRTSPTRAHKASRSSRPVVPSLASHIASAASIPFAIDTALAPERSPDAVSSASSSSTTAFDWPVEGANVNQFRARLLSDSHNPSPLPRTNERMGERASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NWS9</accession>
    <name>A0A2X0NWS9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C015g07965 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C015g07965</name>
        <name evidence="2" type="ORF">BQ5605_C015G07965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY18056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NWS9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY18056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="369" mass="40815" checksum="C8C05C25D559BAAA" modified="2018-09-12" version="1">MASSWKWKIRIPAILASGPSLLASAEERRTTAPAAEQNPRAVITHNFYSQDQAPTALQLTVSLDSSNGAPSSRTAVYLDALDLCESAFTQQILDWFIEHAVSLNLDFNAPKPIVIDSSVLLPMYPLNIHLHLHFNLPLPSKASSPSSPSAEALREWLTSPTSVHLTVRPLITKMLPKLASVLVKQFPNDLNPRWAQRLANDRKSYPYLSKALNDIFLTFEPGSENWIDLQTVKRHLARLEEHTAVEDHFAGGGVIGGMMGLMARRYGNPDAWKAKGGEANSKEGERRSNKAAPSQELQGWEFPDRLLDGSDGELEHVQEEGEEQSFESILTDEDADPSDGILDEDLMSAGLADDDDEQMDSMDILDLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NZT7</accession>
    <name>A0A2X0NZT7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C018g08585 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C018g08585</name>
        <name evidence="1" type="ORF">BQ5605_C018G08585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY25136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NZT7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY25136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="60" mass="7186" checksum="FCA88E29AF5959BC" modified="2018-09-12" version="1">MYSWVHIGRDQKLRHNRQFGATELRLRDLVRQDGQHTYVNRLGSIWKDEVETGCIRDLCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P1C5</accession>
    <name>A0A2X0P1C5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C002g01278 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C002g01278</name>
        <name evidence="6" type="ORF">BQ5605_C002G01278</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NRDE2 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY31926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0P1C5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902369">
        <property type="term" value="P:negative regulation of RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013633">
        <property type="entry name" value="NRDE-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13471:SF0">
        <property type="entry name" value="NUCLEAR EXOSOME REGULATOR NRDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13471">
        <property type="entry name" value="TETRATRICOPEPTIDE-LIKE HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08424">
        <property type="entry name" value="NRDE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="188"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="651"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY31926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1302" mass="147060" checksum="8ED3EDD97232A445" modified="2018-09-12" version="1">MSGSRRPPPPSFDSFPAAEAPNAPSSSPASTRRANPPTTAPSFDSFPAPPIPTPADTFLSGLEQPLDRSKPTKISDKPGHRRSKHHDGSDPSTSGSRGKQNTDKRDERHSSDRKRKHERGHHDRPAAIRDSSNSSSSFSSSSSSRKATAKADQSELGSSDQFQLTEHGYGHKQRKPYQLVQATVADENAKTAPKVSSSVSDDLDNPPYYSSRTGDELNTKYGSLHRSAVPRYRRLGGEPSYSLPAPIDRARLTGTSLVSAGRVVGLNEGLRITSDTAYTGRGVEIGPMRRFRTPRYSDLRSAQHMLDKDLRRISLAAKSTPRGQPRRDPFAERENFVAFDKEHPFEELMRGLEHEEGTDYRSVGGQIKPSDLSTAAASQNTDAAVGENEFDQLGVTGGESESQYLSRRNIEFDRALRDNPKNVELWLEFVEWQNQVALSASGENRGRTILNRVERRGAAQVKLVIVERALKADPANVEDERLVLKLLQLAEEVEDTPTVTKRWKKVLEEHAKMTSLWVRYVGWRQTDGTSFEVESVVEAFVECFETLQRKADLATELQERDMIDANMVYLFLRLCLMLRQAGYIERALASFQAIVELNLFRPVEFQSRAGDEDVHGWRSRTLAALNSFWDDEPPRVGEDGAVGWCNTAVGADAPYSQPDQRISPSTDEDSSSLDRWARSERLASMANPRPARLTDESVDEDDVARVPLFDTDIKPLLFIVDSSDAKQQLIYAFLAFLGLPFVPPDVPTSTPFATDGFIHSRMVEHEDLVKSFWPSKPETTQAVEVIGGEAMEPERKPALEKPWHVPFNAMPCSVELLFAAQQGWFTAINERDLEGVDSELARNALALLSDLSSADDPFLHLDAFAFEACQLPNSAGKLAKSVLRRKRQTLALWDGYARIERARGKVSDARQVYVTALSMYRTFPNHERIDGPLLWRSWAEMEWEEGGADLALKVLVAATAAGDGEDLATLAKTVSIKNTPAQNLRARQFYTTELEASFQPSAPQRLVRNRNHLAVSFALFDYLSHGDLTSFTTEIFEQHLSRLENTGAKGSCEHEEAYQAYVKLLYRHAEKGKRGHRPAQLREVLERAIAEFRNNSMFLSVYYHNELRTKIQNRVRRTMEDLVLTKKPTSQGYLFAIFAESHLDFRSTNVWGVRNLFERAVEDPRTRSCPSIWALYIDFELRNEEFARVKTQLYRAIEACPWCRDLYLIAFRPELKNVFSDQDLRQQWHEAMLRRGLRVRYALPPPPALAESDSDEHAKDEFFHIPLPYIDATKHRLKKEEGERPMDDVETIFREREALKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P1L7</accession>
    <name>A0A2X0P1L7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01428 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01428</name>
        <name evidence="2" type="ORF">BQ5605_C002G01428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY32969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P1L7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY32969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="107" mass="11892" checksum="C45E7704AF2B90AB" modified="2018-09-12" version="1">MSSHQVHQPQALRPATPTGAHLVRPSSKPNSRPGTPSRRAGTPSRVVVNMADEFMKHPPNNLNLADPREQDRASDLIGARNTEPVNNDPPSEEEMRRVQEMANRLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P253</accession>
    <name>A0A2X0P253_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g04227 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g04227</name>
        <name evidence="1" type="ORF">BQ5605_C006G04227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY57146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P253"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY57146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="344" mass="38550" checksum="B84E3CD3D470C624" modified="2018-09-12" version="1">MVRSFALVKIYGMAREGRSLVSGQYPRVKARLVSLYWSLFSRPRRLNSQHSRFSQGRTSGAVGVTSSWGLAAALSRILPVDRHKNTPLAVAVAAGRLNVPPRIGTSAPLEAILPKPVARFAMEQRLPDPVLPQQASQYKLLNMARPYTIRRIRRVLNAKAFTNTLGLKGPPQPDDLRSFWKAVNSKALTAREREVWFKLILCFTPTRKLQHQQNHDTSPACLVCEAPVDDTDHYFFGCVDSRNVWIAARGVLCDALGCDTIEDDQYTTLQPLFGLPKLKAKLSEQEGAGRTIEIFTGMVLEMISSGRWRMQNHGTRMESVERRRVVLEERMKLRAGGARGGRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P263</accession>
    <name>A0A2X0P263_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="12">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C002g01668</name>
        <name evidence="13" type="ORF">BQ5605_C002G01668</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="12"/>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY34690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P263"/>
    <dbReference type="STRING" id="796604.A0A2X0P263"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF134">
        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGY34690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="305" mass="34282" checksum="72D8BB284CA06A8E" modified="2018-09-12" version="1">MVSSSLFASSAGPVRSFVDALPLPSLPSSMLQWTVGVSPLSTNTEVVSALAVYLAVIFGGQYLMQDRKAFQFKSLFMLHNFLLSAGSGLVLALMLEEVLPILYQHGFFYAICHTSAWTSRLETYYIINYLFKYWELADTVFLVVKKKPLQFLHVFHHTATAALCYTQLNGRTSVSWVPIAANLTVHVLMYYYYLMTAAGYKIWWKKYLTTLQITQFIVDLFVVYFASYSYFTAEYFPSLPTYGSCAGTEGAAALGCGLLTSYLFLFIAFYKKTYNQQAAKKNALVAAKKVAAVPTRNIAEFKKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P4B3</accession>
    <name>A0A2X0P4B3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BQ5605_C003g02311 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C003g02311</name>
        <name evidence="11" type="ORF">BQ5605_C003G02311</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY40028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P4B3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="449"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="520"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="617"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="673"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="700"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="870"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="946"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="206"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="237"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY40028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1004" mass="110812" checksum="A50A69C59FB9E0F6" modified="2018-09-12" version="1">MSGHGEPRPTTAAQRGSSAPASMDHHRSKVEVNMTAQMTGDDGDPDAGMFSFMPPVHKATEPIVSGQTAASLLPLDQARVATAHESMSAVDVQSLSALSDPDSTISPAAAYALAAQHGALDGNLRPATSYRQGWTKPEMPDGRFAEGEYDKFREIQFGESRRTSEGTHELGKPFQFVTKRQMPPGTAQFASPFAYRLSATAVQLTDFGGDGGPGHASDDDKSPIGDLEFPVRRHLEEEEEYEDDDEDEDSPYPEVRASVSNYDDPTTPCVTFRTILLGFLVTILVSAANAYLYFRYPAPLITPIVVQLITYPAGKFLAWTLPTREFKLPKICSRMGLGDEFSLNPGWFNIKEHTVLVIIANVATGPAYGLNFMITAEKFYDISYSFGFDILFILTTQMAGFGVAGLCRRFLVWPAAMIWPQNLVYCTLLNTLHAEDENEPGGRVSRFRFLTYVLLTAFCYYFLPGFLFQALSAFSFVCWAAPNHLIVNQLFGVNSGLGMSGLTLDWAQVSYIGSPLVIPWWAIVNIFTAFVVAFWVLAPILYYNNVRERSCNRTYQGVITYVQSSSQVWDSAYLPISTSSVFDRFGAPYNTSIVINKATLSLDFEAYQAYSPVYLPITYAIFYGVGLMTASALIVHTAFHHGPDIVRRIKASTIQDDDIHMKLMRVYKEVPEWWYLIVAGVALGLSICAVAAFDTRMPVWGVVLALALSTLYTIPGGFVYALANVVISINLVTQIVGGYLFPGQPLANMIFKTYAAQSLNVTLAFVSDLKLGHYQKSRSTVTLLADVDVPDLQWFLFGPHVAQLSSTFLACFVQVGVKRLLVSNVPDFCSPTQASHLICPGARVFYSSSIVWGLIGPQRIIGVGSYYSKLLWWLLPGVLLPIAAWLAARRFPRSFAPLINFPVALVGIQLVPPATGINYASWFLAGFVFQYLLRRRRFLWWSKYNFVLSAGLDSGTIIGGIVIFLALSLIGGLWGNTVFTNTLDFLGNSFKVPPEEGFGRTTWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P4L6</accession>
    <name>A0A2X0P4L6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L-ornithine N(5)-monooxygenase [NAD(P)H]</fullName>
            <ecNumber evidence="5">1.14.13.196</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C004g02881</name>
        <name evidence="12" type="ORF">BQ5605_C004G02881</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-ornithine + NADH + O2 = N(5)-hydroxy-L-ornithine + NAD(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41512"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-ornithine + NADPH + O2 = N(5)-hydroxy-L-ornithine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41508"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.196" evidence="5"/>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY68367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P4L6"/>
    <dbReference type="STRING" id="796604.A0A2X0P4L6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025700">
        <property type="entry name" value="Lys/Orn_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF5">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13434">
        <property type="entry name" value="Lys_Orn_oxgnase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY68367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="555" mass="62584" checksum="9F3ED482D9B282A2" modified="2018-09-12" version="1">MSPQISAQDNKEHYTALNANADWVPLCGKCGAACCVLLRLPNPSVVMMVTQAVSFSVLVYQDWVSIHFITSNIQIARRLGLTDVLCYEKSGDIGGTWNHNQYPGAACDIPMSLYSFSFAHPHKLTTQWAGQQEIMRYLHEVQEKFQVHNICFHHEAKQMLFSRDTGLWTLELKELKTGRTKTRTCNILISCVGGLSIPNDPTFDTKDFNGDVMHSAQWNHDVSVVDKDVVVVGNGCSAAQIVPEIADKVKSLTQIARSRQSILRRPPVPDGGWMVFMQNYIPGMSYLFRFLIFLLGEYDFKGMDLIRGQKLRQWVSKDLTSYIREVAPKKYWDVLEPNFEVMAKRRVFDAGYYKALHNPKVDLISDDALETVKGDTVTTREGRKLKADVIVLCTGFKIQEFLFPLKIANDKGEDLATVLGSSNASNYLGTLVAGFPNYFWIMGPNTATGHSSVIFTSECQIGMMIKLIKPILKKLEQNRDASPGPIVEVSKQAQDAYMGKVRAEMKKKVWEKDGGVSWYVNKGTGLCTALYPWSQVHFWRSSAWLSMKDFIYSNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P688</accession>
    <name>A0A2X0P688_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00595 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00595</name>
        <name evidence="2" type="ORF">BQ5605_C001G00595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY47966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P688"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="602"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY47966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="861" mass="92413" checksum="21A791E5795E7BE0" modified="2018-09-12" version="1">MSKYDPTSAAPAQAPRQFLDRIRLTTPAKLNHSSQQPSHSRDSSNLSYFEPGTSALPNTYAIKSASSPRASAPGPAAGARLRPRQKCASADQGRDRLAVDLAIAASLSEIEMQRKRAEREEAELCQALLESAVLARSAADPLSTGQDSSLTAQAVLAPSPVLSSPHEQGTHAATGQRGDEAVIRKPTPSEEWLSYARLRKDVALWLEGGPPKQPDTKKITSNKMGDDYEREMLELAMRISLEEAAQLKRDRQALSTSASGTSAGLEPSSDPIVQPQARSHEEHTQAIKPRRKSVPTSIFLEDLVPLRRTRSSSEPAAPSRDLHSPTSDRLRDSPVLNQFTPSILVDKGKQLDRSYEVLDEQAWMSGELGRPYLSVDSPHEPAVFTSPTASTPDRLTPQAGPSSRVMGCPSAGQIRTAEASVALQPTICDAPSLSSDSASIEFLSPASEIPFDPLEALTVEAAQPLVSADNAADLEDPLSQFNGRPLSHVSEQSEPESEDTGEQSRLSLRGLVPLPPTVRPLEPDPALRSPSSCIPPSKDRPSPRKTVSFKDARSIGSTAQASMEAPATKSKPKRPTIAALVGSSLTAYAALAASIVSPQQFTPPRTTDPDPGTTPTGAAEDPSPDEVSFGYLTSAPGSLAVESVTVDAPFHHKSSGAFPEEIKLSAITPNRRSFAIETSRWSTLLKFIMIHVTLTSFRQGDVKLSTTSADQMAHDHPAECGVTLTFWTTESGQFVLRLVIVLISIDHSIVFGQAHELNIVTHLTYDPDSTRPTQPKSKTRQVVPTSFFLPDPQLLPTRMSTFSISLFMLRHLAHIAHSTQPAKDASASYYALRSLAAAIQATPSQATQIGNSTKAGTVCAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P726</accession>
    <name>A0A2X0P726_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C005g03346 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">BQ5605_C005g03663 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">BQ5605_C045g12217 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C005g03663</name>
        <name evidence="1" type="synonym">BQ5605_C005g03346</name>
        <name evidence="3" type="synonym">BQ5605_C045g12217</name>
        <name evidence="1" type="ORF">BQ5605_C005G03346</name>
        <name evidence="2" type="ORF">BQ5605_C005G03663</name>
        <name evidence="3" type="ORF">BQ5605_C045G12217</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY74178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000115">
        <property type="protein sequence ID" value="SGZ31623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P726"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY74178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY77542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ31623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="35" mass="3872" checksum="AE2178A503389C98" modified="2018-09-12" version="1">MLPACNPGCWMARGLAQHGGWCGLQHVHLIEKKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P918</accession>
    <name>A0A2X0P918_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C006g04281</name>
        <name evidence="4" type="ORF">BQ5605_C006G04281</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY57502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P918"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="54"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY57502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="243" mass="27129" checksum="2C1E595067498167" modified="2018-09-12" version="1">MSQPARGDSDDIGGMASTPPPPPSSSTKNTDSRITQENRLRMRELRLTIPWQSRWQGTYALAVASSGIAALLLPKGRTAHSRFKIPIDIFDDSTCNVPKQEQLAELWDEAPMQHRRCFGTLHVESSRLIRHVYPIPALELDNISIGEKVEYFRERVKLAPKNSQVDHINDMGLDLLPGDAQTFYSADLDTFVAVDVAAQSLIALRPLPKDQLRPMDPPPVNAAISRRSQGQQRLRIDESSVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PC95</accession>
    <name>A0A2X0PC95_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)</fullName>
            <ecNumber evidence="3">1.1.1.179</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C005g03328</name>
        <name evidence="8" type="ORF">BQ5605_C005G03328</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="3"/>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY73934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PC95"/>
    <dbReference type="STRING" id="796604.A0A2X0PC95"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF105">
        <property type="entry name" value="TRANS-1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="22"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="7">
        <location>
            <begin position="123"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY73934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="373" mass="41082" checksum="EAC3E714F51D3D4F" modified="2018-09-12" version="1">MFVTDLLSDPSTREVNDVKHSIYAVASRDIKKVQPFLDQCWEEAKAQEGKEGQANIDCIYIGTPHSHHFQNAYAALSAGKNVLCEKPFTINAAQTQILVDLARSKKLFLMEAVWTRFQPVSLKLQSLISSSVIGPIQTVQAELNVNFAPMAPIDPEHRIFNPVLGGGALLDLGPYPWTQLALAMLPLGPQPKNLEDPLEMLDVQSNMIKLPATGVDGTVVAAIQFPVVDEKAQGGQRKVMGVLMTSQTSQTAPSRCNLIQGTKGFIQVNGPAYRPTSLTYSAWATEQAYANSGNSPINPSKTETFEFEPRPGNILGYAWQADEVARCLRDGKTESERMPLRDTVLMMKVFDKVREQGAFGYPEELETTEIRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PD98</accession>
    <name>A0A2X0PD98_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C005g03537 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C005g03537</name>
        <name evidence="3" type="ORF">BQ5605_C005G03537</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY76986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PD98"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015980381" evidence="2">
        <location>
            <begin position="18"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY76986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="329" mass="35953" checksum="E3EC87288F9ABBB7" modified="2018-09-12" version="1">MLSTFVAFVALLSAVHGQGIVDNSRKMSMIESSEIALDGGNYYVQNVATGRYLQFTRPDDTTDLTSLKSRGSISINYGSAYGKSGKKTGTYVGSVFSGMTKCMSAQFDDNKGVDHAAVSYACSVNGGSGTTTLEKAKQFWKLYPCGSGASSGVSLASKKNGKSKKTSTTFTKKKTTTRKKKTTTKKKTTSKKTSSKKKTSSKKNVKCTKSGKWLARHPEYITRQGNSQCKTTLNAWRHGKSRRSEIVSHHVSQFARLGRRSFMTPIKRALTKRGALQGTYCIIAVDHLSDMETRAVGDSSMNTYGGYVSMELEEWNASDKTQQWIITAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PEJ5</accession>
    <name>A0A2X0PEJ5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C022g09482 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C022g09482</name>
        <name evidence="8" type="ORF">BQ5605_C022G09482</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PEJ5"/>
    <dbReference type="STRING" id="796604.A0A2X0PEJ5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012404">
        <property type="entry name" value="UCP036436"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036436">
        <property type="entry name" value="UCP036436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016109263" evidence="7">
        <location>
            <begin position="25"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="433"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="433"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGZ22390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="492" mass="53067" checksum="A70E2338C3F638B8" modified="2018-09-12" version="1">MVSAPKPPTALQIAVLVAVMLVAGTSNSVFSKWQDMQCVANCDDPARKKVFEQPVWQTATMFLGETLCLVAFKIINSKYNPYNPSRRRVASASARAAASHSQSARLASAPLSRPDESAFNFNESAISLRGDEEEEGIKAAQMAAKQAEENPFAWERAILFWGPACCDICGTTAMNVGLLFVPVSIYQMLRGALVLWVGVLSLLFLGRKMTTSQWSSLATVMAGVAVVGCSSLLDAPKKEVQSTAAEEPAVSPLVGVCLILVAQVFTASQFVLEEKIMERQAVEPLLAAGFEGFFGLSTTITGLLILHVFIGSKPSGQGGYFDAPEGWHQIVSNPSIWSSSIAIAISIALFNFCGLAVTRTLSATSRSTIDTSRTLLIWLVSMSLGWEHFKWLQVIGFGLLVYGTFVFNGITQFPKWTGLRDAPQPITVILPASDDELSDGDDDDDVDDHLSHSNSSLGRSRSVDTSGRPMTKRSGSGRRGEVSPLLKNIDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PFN7</accession>
    <name>A0A2X0PFN7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C024g09936 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">BQ5605_C048g12402 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C024g09936</name>
        <name evidence="3" type="synonym">BQ5605_C048g12402</name>
        <name evidence="2" type="ORF">BQ5605_C024G09936</name>
        <name evidence="3" type="ORF">BQ5605_C048G12402</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ26547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000110">
        <property type="protein sequence ID" value="SGZ30538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PFN7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ26547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ30538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="35" mass="4112" checksum="ECC6BED46696B7C6" modified="2018-09-12" version="1">MHADSAIALEPHRKRVQTERIKRCNSQAKKDYSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PFQ0</accession>
    <name>A0A2X0PFQ0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">BQ5605_C025g09957 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BQ5605_C025g09957</name>
        <name evidence="16" type="ORF">BQ5605_C025G09957</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
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        </reaction>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
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    <sequence length="693" mass="76723" checksum="BB060DBD95C392C5" modified="2018-09-12" version="1">MDVLARFHFDTTTRGATVPMTPGLSLTAVLGQGTERIRSWYLQAIGSLLYISLGTRPDIAFAVSYLSRFANNPGRRHWVAVKHVLRYLRATYRDELLYACGPTKITGVVGYSDANWGACVDTSISTMGFVFYLAGSAVSWSSKRQTRVADSTTDAEYLALSHAGKEAIYLTQLLSELHVRPVDAAHIFTDNEAAAAVAHDPVHTSGTRHIRLREHFVRDMVHQGDISLSHVGTANMVADIFTKALGPKIFGVHCYALGLRTRHPRLKSTSRSRGGGLELIEYTGHPITLRGVLHAPGLHINLLSVSRLCDTDRVRLAFTSDSIDITKDGQAIAHGTRVNDGLYLLDADHTKCQRLAFLSRSESTVPLLTLHRCLGHLAPSSIQKMIAAGLLDGFGAGYSDKDVEEFVCNACLGSKGHRLPFPDSESHSPERLGLVHSDVLSFPTPSLTGKRYLVTFLDDHSRKLWAYAIDHKSDVFPTFQTWLAEVELETDARLRILRTDNGGEYRSNAFTEFCQSRGIRRQYSIPYTPQQNGRAERVNLSIVEGVLALLADSHLPATFWDEAAAYFVYCKNRCSHSALAKQTPQFVWNGQRTTTTALHPFGCAAWLTVAPDLRSKLDPKAARVIFTGYDLASKAFRFFDHSTNKVVLGRNATFLDDDFPGLPVNTPVDADDAERQSGVRCWQQTVHPPCQWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PHT2</accession>
    <name>A0A2X0PHT2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C031g10901 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C031g10901</name>
        <name evidence="2" type="ORF">BQ5605_C031G10901</name>
    </gene>
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        <name type="scientific">Microbotryum silenes-dioicae</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000068">
        <property type="protein sequence ID" value="SGZ05912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ05912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="63" mass="6830" checksum="0A06C15A28A1F935" modified="2018-09-12" version="1">MPCQPVGQGHRGPVPEAPLGWDDVQTDRPARPVTSVRCAMSARPNRAAPDIVCEFKLGLQGYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PN92</accession>
    <name>A0A2X0PN92_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C027g10323 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C027g10323</name>
        <name evidence="7" type="ORF">BQ5605_C027G10323</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28370.1"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:histone catabolic process"/>
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        <property type="entry name" value="Homeodomain-like"/>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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        <property type="entry name" value="Snt2"/>
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        <property type="entry name" value="Znf_FYVE_PHD"/>
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        <property type="entry name" value="Znf_PHD"/>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
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        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SNT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47672:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SNT2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BAH" evidence="5">
        <location>
            <begin position="17"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="804"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="267"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="566"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1009"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1076"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1182"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1452"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1571"/>
            <end position="1599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1689"/>
            <end position="1768"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="316"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1014"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1111"/>
            <end position="1124"/>
        </location>
    </feature>
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        <location>
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            <end position="1222"/>
        </location>
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        <location>
            <begin position="1278"/>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="4">
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            <begin position="1328"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1348"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1417"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1476"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1503"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1541"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1689"/>
            <end position="1705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1724"/>
            <end position="1734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGZ28370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1789" mass="191635" checksum="DF3739D713437AA5" modified="2018-09-12" version="1">MAPRINASTGKLEVKGKVLEVNDHALVSAPWLDREGEPYLVARILEVLPPVVSSGSSTPTTQGSSSKRPASTKVSNTVPRVRVNYYLRSRDITSRYVADFRLVVATMHADVIPIAYIRHVCTVQHKEHIADMRAFKALPDAFYWSQVYDRYLHRYFDAVPVNKVQNAPPDVVKHLTTHFEFILCEPSMTNELCDAQRGCSKCSEWAASSDSVICARCAKVFHLGCVDPPLAQKPKAGWAWACAPCARAHQVEVDAYMETGIAPTRHAAIAPKPHKSNGKGSSAPDSSSKDALKNGTKLATAKGSECSAESAASAQDRGKGKEVDLGKRGPYAKSRQWRMLNGWPFRYYGMHTPSNSVLDRHDSIYPRTGTRLGHRYQITIPAWDYAKAEPEAPAPMFGAVASKPRRKVDGSTSALPKIKKKLLNMQTIRRGEDDELAGVIADPKLGIDDDLLDEVVEEVKRMILYRHAGVDALNRVLSLLVLDDKHEVATALDAMRKLTQNDLGFPPWTEADRKKLSDGVQKHLNDIEEIRKSLLPNKKMRDVVKRYYIHMGHLVQEDIPAQMDERAMAASAASPDKKKKKSSAKNGGRVASGQDSSNANDSDGESVVDAPKSVVVGKKEWTCSICDITKTPKWYLCPDTLNDDLVTPEPCVMCEECGIRWRHYGIQFAPTDTDDLAKTAPLPDGIVHNPRDFKGKKVAAPSDATTTASAAQAGPKAGAGAITGAVVPVKATVASGSHEPVWRPCLLCKRVPPMREHASCLNCGMTVHVSCYGINGLNFPNLKKWICDLCDIEEGKKESLKVRQPLCLLCPPRTVQKSKRFTALDCMKLTEFDNHIHLLCAVWHPEIKLTVPSDLGDAEGLSLIPSKRRLATCVLCKKDAVGACVKCAQCPKMFHVSCAWIKPAYRLGFEVHPIRKKKPKETPTVKFKDEEGELVAAIWCNEHSGAAAPDQVLHDISARDPATNLTAMQMHARAFKSSPDDTYMLLRRARRLDALVEPVLNPLKQNLPRVPPGTSWSRDSTLSRTSVLSKKRRTPRNIHELTLRPSFTLLSPALPESPSPKKLRLHEVSARLLDLKRNRRSSSSSEEEAHPETLEPPTAKRAKAAFASGSPEASSNGRAASTGATPVRDPPHCAFMGIDESSQEIEEEWTGSTTPTNSPPSWRFSFAGLIARLNKARRLSGLPIRAPSPQPSPTQATSPSPAQVSPKSKRPMSPSASSSTPKIKVKPSGSDFSSTSALGFAPPLPPPNRAGKLIPGPALVASSTKKRSGPEVGPSNGATRSSSSTPASKPKSQSRKSTFRIGPLPVSKERPSSKAKAPVEPKLPARKSQFTVTPSSTIKRRQARDKQTAQAQTDTTPSSVVGGRASGSGSSSSGARAGPVAEPSRSSLPIANPIASVANPQFAALSDRATPASTAENSDEAEDSEDAGTRRSKRKRVISEAARDAIEFEKALAELDRDDPAIDVTSMNGSRPAMHRLSTGGATRGARGAHRRGRGRHSDAAGTSRSAAASKQSRGADDTGAGSPRWRSGVEDKKNVEVQATSSTSSSTPSTSSVTSKTSGIVVRFSIGGKRVGDADTISPPHVEPKTSANAKVKPPLGVDQRFGDSGMSSSSVGGHVALVSNGVTVPAAPISSLPFAAAAQSNGHAGLSSISAENPAMVPKKPIITWNRAPLAQPSDTDRQALTTSLPVAAAEPRATPAVAPAEPSTVPVATKSNGGFAPPLQKPSTAGLTTASPPVRPEFRLGPGPNQAAASSLPGLPNSSATAPFPASDAFPAEVAVVNQDFITSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PP35</accession>
    <name>A0A2X0PP35_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C042g12009 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C042g12009</name>
        <name evidence="2" type="ORF">BQ5605_C042G12009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000116">
        <property type="protein sequence ID" value="SGZ31807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PP35"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ31807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="200" mass="21717" checksum="73359A42F3FB2BD5" modified="2018-09-12" version="1">MNPSTSRRRSSTPPSSPPYSFSNGHHEPFGSSLSQSTSKRPNLSTVNSGINTPTEQDHYDIYCIPCTCPCLSVPQTTAYPSASFLIVHRQSGMATGLGVRFGIQSSSTSPEALIGVVADPGFSLHREEGFDKDKAVLLGWVEQERLGFLEQIIRAVEIPKPQNGREMLDWLLAVARVLEYEGIAANGELLLGDILDARTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PPY9</accession>
    <name>A0A2X0PPY9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C140g13427 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C140g13427</name>
        <name evidence="3" type="ORF">BQ5605_C140G13427</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000143">
        <property type="protein sequence ID" value="SGZ35697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0PPY9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1246"/>
            <end position="1531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="628"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="690"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1813"/>
            <end position="1850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ35697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2044" mass="227036" checksum="590481D24BAAB40B" modified="2018-09-12" version="1">MQTGDPGSAPGARAPPPPASAPTSLPIAGTKETQATQVAGRTATYAAATNSSVVSNETPAQQQDRLARLQALPGILAAIQAVPGNRADRFVQAIFATPDFPSTVATALKFSALNATRNIINPFANALEVSLSHKSTGRASATDKGELVACVRTLLSPNTPICFDTGVPLSGDLEAFMPRITGLQHSSTFRTGVLHHRITVGFVSAEARDAALASAPMLVWNSANARFAKAHPFHRNMLEMRINVGVVRPPSKEQIVAAFQSIVQQLSTKGHSCQLVQVLRVIHVDTAKAYAHTVGDFSAFIHFDDASLFQHPTTTLKEILPSRMDLPTRGLDVTAVRHDYEKEAPCARCHFAGHVERCPLMQAANRKEAEDLARHAVMRGAGMVGEESRQEWVVAPSRALGTDQLESRNRFAGLEVEGGQEDDIEEEVAGKEGEEKEQVEEGDEDTGAKADDEDSDSDGNAGAGIDKAGGDGKDDDKDDDEDDDKDEQDDSSEGSERRGDDVMKDGAEEEDERMETEVEEEVEQEQGVQDDSIMIIDDGQTTITTVSRESTPRSPSWPPLSPETLAKSLREGAEWDRANAEAAARVQAENEAIINAQLDAQEPLVRHQFAEWGQEDGQLRFINIRGTGSRSNKKMKRSQTVADLSDPSDDPVDVKRVLNRVKGRAGKEVAGQGKRVTRSMSAAAAMQVEGAKAKAEKGKGVEEEKRWSDHEPEDDILPEFPLFEDNITAKSTWNVRRCMGIPEKRRDIYTYLSTFKASAILLQEHFIKPELWQCIKDEYEGKAFISKHCLTLIPADSPLIDAEILRTHSALDGRILVTSFRLRGDIRILEINNLYAPVDTKQRLTFFDKLHFHRTQSTHLRLLGGDLNDCPLPAIDRRNQGRHGHHWPILIGKLDSPYTDCIRFKHPLTPSFTRPNIVRKRPKSFSRLDYFLLQRTHQKRLVQASTIYDHPKDLSDHRPVSIVLVLSDERGDAAQPNNSLPTTSNQLHRINAATFKTAAFQGMLEGWLEGASGEEPVGELEVVLGNCEKEGRELARREHRERVERMAVLVGRVQDLEALPVMGDEETAEWTRTTEELRRAVNERARQLRIRAHVPEIATEERLSRPVHAKLAARSSDSKITALRLPNGELTHDIDVALDHTQAHFQRLYNLEPRDRDHVERLRDDFLAPIRSARTCDDPSSDPLFLRRLSEAHIELLQQPITEDEVVAAIATTHPGRSPGPSGVPYELYHTAPRAWAKALSRAFNAMTERGSLSPRQGQGLVRLLFKHHKIGADRAELSSYRPITLRECDYKLFTKVYVARLNHVLPDLLPPQQHGFVKGRRSADASFHLRLLIEELGARGTEFPDAALLSLDQSSAYDLVEHEWIFAIFDALGAPATFQRVLRMLYSGDSTTARYIINGFLTPPVRLTCGLGQGDPASSSVWDVVFQPFLDALHRRGIALNLSLPTIHPYPQSRAITSLAFADDVVVAVAGSESLTLLDDLALDWRLATNGRLNTDKTVVLPIGCRWEAGDRPLVVKAEGESLEWIGLSFDPTGNTELANVNLVARLEAVLDSARDRGLTHHTRAFYVNRYAIPKILHILSADIPPLEVVKELDRILVDFVRGGKRRSCYGKDVVFTPRFKGGLGVMRMQDVVDSVAARVWDVLLGGSDAIWQGLARAAIVRAHPAPDFDLATDAWPCDYTPIRTDLHPRWQAVLKVPSTHNAQVKPRTLTLANLLALPIKLHTLHYLPGAPAVSRSPYDADYAAFANYAKVADLFRRELYPGGGFHLWTPADGCGRQQQRIRSTGPPTTRAHCGMVPTCDQSIKVTPIAQPVAASTNQRASRVRPRSEVRPTTPLESILPHPIDPPQRLPRPALPDQSTQYNLLSMDRPYTIRRVRRVLNAKAFTDTIGFRDSLQPDDLKGFWKGVNSKALTAREREVWFKLVRNFTPTRSLQFHQKHGRLARVPRLSVLCDALGLDTIDNTHYTAVQRMFGLPKLKASLRDQEGAGRTIEIFTGLVLEMISSGRWGMQKWGTRMEGVVRRRIILEERLKLRAGGAWGRRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LRW8</accession>
    <name>A0A2X0LRW8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C013g07375 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C013g07375</name>
        <name evidence="1" type="ORF">BQ5605_C013G07375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LRW8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY15468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="416" mass="47522" checksum="7A133C715F4AB6A6" modified="2018-09-12" version="1">MDVRPRLPPELIEAILPHLVPLPSTPLWMLQLEDLTTLRACCLVSSQWRAYAQPQLWSRVIFSTTEKLTQFVQVLRASDLQFLQRAVKELWIIAEHERGVNNLFGDYIALRMFPGLRALRVEGLHIPHAFLSFGRVPPLASLSVSRLAVYHPEDMRLLNPSLDNRLADSCNPVPLRHLELRNMFGCSARGSLDKIIHGRNHLESLSIVEALDMQRMEYLWCMQTLTSTPQRSSSSSQTEDSSRQSGLKKLSLTFSPGWGASGRPYDVNLSQQMSEFVLMAPRRVIWPDFFCYDFDSIDAWTILLPQCPPTLTDLTLSLFTAVPWVQLLIHVLPPSITFLTLLLDREAENPNRTEQGYQDTGLQVSRMVLHELKDDKMPNLRRMLWRDRSGACLGFLVGARLREELAQRGIELIRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LSN2</accession>
    <name>A0A2X0LSN2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C093g13066 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C093g13066</name>
        <name evidence="1" type="ORF">BQ5605_C093G13066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000005">
        <property type="protein sequence ID" value="SGY11557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LSN2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY11557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="104" mass="11548" checksum="7BFD2CBD22F7D7F5" modified="2018-09-12" version="1">MIPCFSCFFGEKLEVDDHNTFFVLFFCFTGAHKLQSFGLAGIFFFFDWAHKLQSFGLAGTATKRAKGGYKATTASSWVKVKPLRAKSAAQIKTRRAPNADSNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LSV1</accession>
    <name>A0A2X0LSV1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C091g13055 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C091g13055</name>
        <name evidence="3" type="ORF">BQ5605_C091G13055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000003">
        <property type="protein sequence ID" value="SGY11524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0LSV1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1268"/>
            <end position="1553"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="2260"/>
            <end position="2545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="650"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="712"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1847"/>
            <end position="1872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="713"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY11524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="3053" mass="340585" checksum="92A7BD0055B10434" modified="2018-09-12" version="1">MQTGDPGSAPGARAPPPPASAPTSLPIAGTKETQATQVAGRTATYAAATNSSVVSNETPAQQQDRLARLQALPGILAAIQAVPGNRADRFVQAIFATPDFPSTVATALKFSALNATRNIINPFANALEVSLSHKSTGRASATDKGELVACVRTLLSPNTPICFDTGVPLSGDLEAFMPRITGLQHSSTFRTGVLHHRITVGFVSAEARDAALASAPMLVWNSANARFAKAHPFHRNMLEMRINVGVVRPPSKEQIVAAFQSIVQQLSTKGHSCQLVQVLRVIHVDTAKAYAHTVGDFSAFIHFDDASLFQHPTTTLKEILPSRMDLPTRGLDVTAVRHDYEKEAPCARCHFAGHVERCPLMQAANRKEAEDLARHAVMRGAGMVGGGEQTGVGRAATTTTNNIRPTANNNNTSEVVAPSRALGTDQLESRNRFAGLEVEGGQEDDIEEEVAGKEGEEKEQVKEGDEDTGAKADDEDSDSDGNAGAGIDKAGGDGKDDDKDDDEDDDKDEQDDSSEGSERRGDDVMKDGAEEEDEGMETEVEEEVEQEQGVQDDSIMIIDDGQTTITTVSRESTPRSPSWPPLSPETLAKSLREGAEWDRANAEAAARVQAENEAIINAQLDAQEPLVRHQFAEWGQEDGQLRFINIRGTGSRSNKKMKRSQTVADLSDPSDDPVDVKRVLNRVKGRAGKEVAGQGKRVTRSMSAAAAMQVEGAKAKAEKGKGVEEEKRWSDHEPEDDILPEFPLFEDNITAKSTWNVRRCMGIPEKRRDIYTYLSTFKASAILLQEHFIKPELWQCIKDEYEGKAFISKHCLTLIPADSPLIDAEILRTHSALDGRILVTSFRLRGDIRILEINNLYAPVDTKQRLTFFDKLHFHRTQSTHLRLLGGDLNDCPLPAIDRRNQGRHGHHWPILIGKLDSPYTDCIRFKHPLTPSFTRPNIVRKRPKSFSRLDYFLLQRTHQKRLVQASTIYDHPKDLSDHRPVSIVLVLSDERGDAAQPNNSLPTTSNQLHRINAATFKTAAFQGMLEGWLEGASGEEPVGELEVVLGNCEKEGRELARREHRERVERMAVLVGRVQDLEALPVMGDEETAEWTRTTEELRRAVNERARQLRIRAHVPEIATEERLSRPVHAKLAARSSDSKITALRLPNGELTHDIDVALDHTQAHFQRLYNLEPRDRDHVERLRDDFLAPIRAARTCDDPSSDPLFLRRLSEAHIELLQQPITEDEVVAAIATTHPGRSPGPSGVPYELYHTAPRAWAKALSRAFNAMTERGSLSPKQGQGLVRLLFKHHKIGADRAELSSYRPITLRECDYKLFTKVYVARLNHVLPDLLPPQQHGFVKGRRSADASFHLRLLIEELGARGTEFPDAALLSLDQSSAYDLVEHEWIFAIFDALGAPATFQRVLRMLYSGDSTTARYIINGFLTPPVRLTCGLGQGDPASSSVWDVVFQPFLDALHRRGIALNLSLPTIHPYPQSRAITSLAFADDVVVAVAGSESLTLLDDLALDWRLATNGRLNTDKTVVLPIGCRWEAGDRPLVVKAEGESLEWIGLSFDPTGNTELANVNLVARLEAVLDSARDRGLTHHTRAFYVNRYAIPKILHILSADIPPLEVVKELDRILVDFVRGGKRRSCYGKDVVFTPRFKGGLGVMRMQDVVDSVAARVWDVLLGGSDAIWQGLARAAIVRAHPAPDFDLATDAWPCDYTPIRTDLHPRWQAVLKVPSTHNAQVKPRTLTLANLLALPIKLHTLHYLPGAPAVSRSPYDADYAAFANYAKVADLFRRELYPGGGFHLWTPPTDVVVSNSEYDQRSRPQREHIVAWYRHAINRLRFTPIAQPVAAVRINGPPRVRPRSEVRPTTPLESILPHPIDPPQRLPRPALPDQSTQYNLLSMDRPYTIRRVRRVLNAKAFTDTIGFRDSLQPDDLKGFWKGVNSKALTAREREVWFKLVRNFTPTRSLQFHQKHDDSPACLVCGAPKDDREHYFLDCVDSGNVWIAARSVLCDALGLDTIDNTHYTAVQRMFGLPKLKASLRDQEGAGRTIEIFTGLVLEMISSGRWGMQKWGTRMEGVVRRRIILEERDLERRGSWWLRSRALVFVSTEWEVAVGWAFCLPSVDSREGQSASIRTRLNRRSRQTSIVSLEDVDGTETVDMQEALGIASRHAQSLFTPDPARGDPTNPRRSLLDPIRAAKCYDDDRSDPTFGRRLPLQARVALDEPFNLSEVEAALKKTDSGRSPGPSGIPYELFKALPTYFAPKLLDLFNSIWEGGKMTASLAEGLVRLLPKNKPGANLKSLGAYRPITLRETTYKVLSKVLVARLNGVLGELLPPAQHGFMPSRRSADAGSHLTLLLEKLRSLGTDVFPEGALLSLDQQSAYDRVDHAWIFDVFEAFGFGERFISLLRALYDPETLGVRYLINGFPTELVRLLCGLGQGDPLSCPVWNITFQPFLDALVRRGIALDLQKVWPGGPRAQLTHLAFADDAVVVVESPAALSKLETLSQTWYEATNGKTNTDKTLVLPLGPNWLRDETAQALPTVQEGESFKWCGYAFFRHGDSKLFWTHVLDRIKAKTRAARDRTLSPSGRVFYANAHITSTVLHVLSFDIPPQWFIQAAETALTDFVWGGPRRNTVAREFVFQAREDGGLGLISIGDIVHSVALRFWDAVAGSNEAIWAPLARESWRSLVAATRDFSPWGFFSSTARVEKLYRDSTRWGAVVAAARVTVPTIKSELLTLPELLSLPPRLPSLYAEGAKHAYDDADAVAKFAQIADLYWRDEGKGWALVGHRRGFWQHSKEPALQHEHVWSRVGQLLKAKALLPKTALRPARIPLKEAPRPRCFNFFGLTRPFTIRKLRRLVNVVRFPGREDRVKRFRDGTSQSDRKRFWRWLHDRFASAVEQDTHWRLMYDVTPTRKRQHTQGHASSPTCLFCGNDAAVIETVSHYFFECAYSTSFWGGVLRILFDKLGIEDTDVDPSTFTPEQLTMGLPLLRGRGRTTSRWMWVRLACAIGFQRLHLLRWRVHQRFELDKVVAPPSIPSALRAFKRDFLSRAGFVPGARDWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LU52</accession>
    <name>A0A2X0LU52_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C011g06670 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C011g06670</name>
        <name evidence="1" type="ORF">BQ5605_C011G06670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LU52"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY12975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="52" mass="5692" checksum="CE7E055C0BF982BC" modified="2018-09-12" version="1">MSRKAAEHCGVKPEAEGHVPSCFDGKWNLDERWNLGERGRNGLSPCGLSPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LUM9</accession>
    <name>A0A2X0LUM9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C010g06069 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C010g06069</name>
        <name evidence="1" type="ORF">BQ5605_C010G06069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LUM9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY14119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="91" mass="9782" checksum="9A23AC524B452387" modified="2018-09-12" version="1">MTMGAVRRGLGGDSWRNLSPLASCRPSFLATEGESTEGDRVGWVDSRGDGKLVLWGYLGVGRVDRTDLLESKSPSPIVDVDQYEIGVGRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LUN2</accession>
    <name>A0A2X0LUN2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C017g08310 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C017g08310</name>
        <name evidence="2" type="ORF">BQ5605_C017G08310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY19782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LUN2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY19782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="325" mass="36268" checksum="901CC3E0DB8E59D2" modified="2018-09-12" version="1">MTHCSLASTVVGLPILQSSTEELDVKSLENQLGQIRRDLQALRAMLEPEITLINTPSIDHLKSLLPPAVKIFVATPFFYKHLASAESFALVLTKSGLVPTEAYNKNLPFRHNLLSNIPALLVQGRSDLLRHIHKSQKDKATLGRTINQWYKGQQVAVTEGHVTWWSILVRIYEEPASTLDPDLRLYSLYQWQAMKVPNVSNPSDSKANSFASKLKRYGDRLAADAATTHLAGGYKRNGRLTITREIHTSWSLFDMVASKMKRHSGIRTTGQNTLSDHTMQAVCSEVVDDPANNLSFASRVADAVQEIGENSGKARKKKRTEDPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LVN1</accession>
    <name>A0A2X0LVN1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C016g08265 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C016g08265</name>
        <name evidence="3" type="ORF">BQ5605_C016G08265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY21699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LVN1"/>
    <dbReference type="STRING" id="796604.A0A2X0LVN1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF2">
        <property type="entry name" value="CAPSULAR ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="578"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY21699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="718" mass="79535" checksum="081477E0C7F250EC" modified="2018-09-12" version="1">MPRVSLNPVQRLVIRVAVVIVTCFSVKWLIWDSKPTTPYGEVAHPAILERITLGSPLSGQPLDTKKYPFLQSRINRDESPDIFDTDIATGINDFWNRFQKPFATNSDTMHLDEQVVRGAVDELLSFNGWAAAACASLTRPFGNKKDDNWSDLAGQGKLYYFALIVHGADHFVVDQLAVIVQLSKQLGAGSIFVSLVDYASSDSTPFLCDIAESIFLLLGISYRIRQVPAMTQDPAAAYYPLEEAYTRNLALEPLIELWERRKVKFSRVIWLKGFTCPNDLLETIRVSEINEAAMVCSMDWKEHNGFFIYNDRWRTRDMDGNLFRGSKSTSPIDEAPPRDAYGGARYTLHLPFQVFCCESGSHVVDPHQSYYHGVTYQSSVQGVFNTTSASDGKTPPKWSEGPCMDSSQVHFCRDMWMVAFRNGIKEEAKRIAHDEKIGKARKVHPFMQDLIAAATASYSPTTNDKVGYPNSGDYLVDETGASPDGKPKASTEGGDGEGDEEDDEEFDEERDAADAEMGLEPEPYDADEGGKGRPIDLAVKIEDEEGAALATAADVSVAEGETSSDAAPPLPPPPPPAVEGEAGPAVAAPVEVRAKHKRSVSIPSEAHKKRKLSKRRPKSLPNAQFDYAVARILVNPRCVTTYAGVSHIQLALDLFGTGEDKEPQMKKNAQYVLDEWRTPPESFTCQEMRTTGGRTAPKQQRRTGFQQARLLLNGWRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LXB6</accession>
    <name>A0A2X0LXB6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C087g13027 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">BQ5605_C112g13227 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C087g13027</name>
        <name evidence="4" type="synonym">BQ5605_C112g13227</name>
        <name evidence="3" type="ORF">BQ5605_C087G13027</name>
        <name evidence="4" type="ORF">BQ5605_C112G13227</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000038">
        <property type="protein sequence ID" value="SGY28572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000106">
        <property type="protein sequence ID" value="SGZ30271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1087"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="455"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY28572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ30271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1880" mass="206197" checksum="C9D0F8C21B9D05B5" modified="2018-09-12" version="1">MPDPPGAQAPPPDNPLGGNRASDDESLNTLTREPVTGGTANPPAWSTEATQARLDCEKVMQNTFRVLGIVPSGKSTRRLMVLMHDASTPPSQAPLLARAAQRAVRNDAAPASNVIRVIMDGPGSPRGPVQIALRKHFGLAETPFMFARPEGVVLDPEVEKLFSKCVKLNPIVTKATKRFPIARHMYELVFESDQACLEAAAAGPFSHHGKEMVTELPSASPLNHVVQVRFTLPSSSSATPASVLRQSLDDALTLSFGRAGRTQGYTLMQLQRGLAVDPNGDPMAMTEDGFHCAYLRLHADLFQGSTETQKAALNAALPQEIEILGAKYGLRHEFETHYCAVCDRAGHQWGACRKPVSTPATAAPVPGASTSTSTTGFRVAGKNGKHGGPAALNSRASGTNMIQLGPRANPAGAATGNKDDANDDDGDDDDDGGGESVASTEPEGGDTGKETLTRATTGPTKETQTTTAAPVSTPTSPSPSTSAPASPLSGGTSESSATSTTSIASTSPRRLRSSSAPGNRRVTRAGSAMIHGASGGDDSGGNSSGGYRSESLTVLTFNVRSIKNAVNQVKIIRYLKTLRPAPAAILLQEHHLSYNASREGFESAWPGACIRFTPHVLTLIPDGSPLAGHLLSSTPVVFAGAPRLDGRILRSVFRLEELDVEIINMYAPVQEDDRRDFFGLLHFNAPRPKTLRILAGDLNDCPDVSVDRVSITDRAWTPVSHWQTLLSKIAFNALDTVRHVHSCTPAFTRPHYRGRGEERKICSWSRIDYILVQCSWANRLLSASTLFDAPCSDHRPVVATFALPTSNADAEPPLSLPSTSDFISRLNPTVFDDQDFVASIPGVVDEVYRRLEGTAPLGDVYDAALRAVAVAGHARYRSTRADMRRLRAESQSVMEALEARGEHMNEAERDAYAFAKSRLDQLAVKEAQWLRIRAHVPSVDSREGQSASIRTRLNRRSRQTSIVSLEDVDGTETVDMQEALGIASRHAQSLFTPDPARGDPTNARRSLLDPIRAAKCYDDDRSDPTFGRRLPRQARVALDEPFTLLEVEAALKKTDSGRSPGPSGIPYELFKALPTYFAPKLLDLFNSIWEGGKMTASLAEGLVRLLPKNKPGANLKSLGAYRPITLRETTYKVLSKVLVARLNGVLGELLPPAQHGFMPSRRSADAGSHLTLLLEKLKSLGTEVFPEGALLSLDQQSAYDRVDHAWIFDVFEAFGFGERFISLLRALYDPETLGVRYLINGFPTELVRLLCGLGQGDPLSCPVWNITFQPFLDALVRRGIALDLQKVWPGGPRAQLTHLAFADDAVVVVESPAALSKLETLSQTWYEATNGKTNTDKTLVLPLGPNWLRDETAQALPTVQEGESFKWCGYAFFRHGDSKLFWTHVLDRIKAKTRAAGDRTLSPSGKVFYANAHIISTVLHVLSFDIPPQWFIKAAETALTDFVWGGAGRNTVARDFVFQAREDGGLGLISIGDIVHSVALRFWDAVAGSNEAIWAPLARESWRSLVAATRDFSPWGFFSSTARVEKLYRDSTRWGAVVAAARVTVPTIKSELLTLPELLSLPPRLPSLYAEGAKHAYDDADAVAKFAQIADLYWRDEGKGWALVGHRRGFWQHSKEPALQHEHVWSRVGQLLKAKALLPKTALRPARIPLKEAPRPRCFNFFGLTRPFTIRKLRRLVNVVRFPGREDRVKRFRDGTPQSDRKRFWRWLHDRFASAAEQDTHWRLMYDVTPTRKKQHVQGHASSPSCLFCGNDAAVIETVSHYFFGCAYSASYWSGVLRILFDKLGIEDTDVDPSTFTQEQLTMGLPLLRGRGRTTSKWMWVRLACAIGFQRLHLLRWHVHQRFEKDRVVAPPSIPSALRAFNRDYLSRAGFVPGARDWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LYN4</accession>
    <name>A0A2X0LYN4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C014g07622 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C014g07622</name>
        <name evidence="3" type="ORF">BQ5605_C014G07622</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY19341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LYN4"/>
    <dbReference type="STRING" id="796604.A0A2X0LYN4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039765">
        <property type="entry name" value="Yip5/YIPF1/YIPF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY19341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="361" mass="38404" checksum="C1611C4DB025FF86" modified="2018-09-12" version="1">MSRQNSSTLFDADESATQPLAFQEFGSTTIASDVPSGRISPSGGSRSGSVGGGGSSAPSNLYEAEQRFEQTLNGATKSGGVLNLDFYTGYFDVDTVTVLTRGARTFLPREDYVGEVLSGVPDLYGAFMFTTREQFVPVARVLKPVLPLPGPFWIPTTLIFSLFLISSLSASVEAYLASEQYTYDFTRLGAAVSLVYMYCLGLPFIIWVALKYWAGSTERSAVEIVSLYGYQATIWIVTAASPKAHLFPRALAWLTLIPYSPLRAVLVLIATALSGAFLLRNLYPVITTAPNVSSRALLIVIAVLHLVLAIAMWVGFLAGGRGVLHTPQVPSIPGTGGGKTPTTGSDLPAPGGDGVAARLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LYW7</accession>
    <name>A0A2X0LYW7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C017g08506 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C017g08506</name>
        <name evidence="5" type="ORF">BQ5605_C017G08506</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY20170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LYW7"/>
    <dbReference type="STRING" id="796604.A0A2X0LYW7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
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        <property type="entry name" value="RNA RECOGNITION MOTIF-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RRM_1"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RRM"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
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            <begin position="237"/>
            <end position="310"/>
        </location>
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        <location>
            <begin position="328"/>
            <end position="405"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="408"/>
            <end position="490"/>
        </location>
    </feature>
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        <location>
            <begin position="519"/>
            <end position="693"/>
        </location>
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            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
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            <end position="93"/>
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            <begin position="104"/>
            <end position="116"/>
        </location>
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            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
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        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
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        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
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        <location>
            <begin position="429"/>
            <end position="454"/>
        </location>
    </feature>
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        <location>
            <begin position="534"/>
            <end position="548"/>
        </location>
    </feature>
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            <begin position="564"/>
            <end position="575"/>
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            <begin position="627"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY20170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="710" mass="73810" checksum="4471519DE4AD00F7" modified="2018-09-12" version="1">MAYRYDPYASTPAGGQGGGSSSYPPPPPQQQYPSGNPGYGGGSNYGAGAGAGAGAGAGGGGYPHPHPASAPGQGYNDLSSGVTSIIPQTGPTRTQHRYGHHQPQAHQSAYSPSRTAGGSAIESNERGWGAPPSPPRRLSNSMSASGPRSGWEDDGAYYEGGSGSSRGGGGASYRGDRGRGRGGRGRGGGRGGGAGGGYGGGGGSPSRREYDEPNRFVRRPDFDSVIDERVSRERPCRTLFIRNVKFGTDVQDIRDLFEPIGHIKTLFDMLDKRGMVFLTYFDLRAAMMAKDKLHEKRLSGRPIDVHYSLLKDSDLEKTCDSDKNQGSLSLHVVGARGPVDEREVHARFGVFGEIKHVVASAARGGGRQGSTLIEFFDSRAMERAFHEMNGQPMAGGTIELRYDWDLTTLHPAPPTEAHTPRPNPPPSRSRTDRSDQDPYTRDGRPQRDHQKSSREYSPPARRNYSSEGSYPSGGTVHQGYGNGTPSASATTALPDQLEQARKMQALLATLTAANNATAAATGGPGVPALSPQGALPPPAGFYLPPPPGSTITPNPYTAGPTPAYPGYGNSYGPGSIAPPPQVGPTSISTGQYGNGPLATAGIHHSSPPPPQGQGQDQAGRVSYPPLQQQQAATSSSAHAQPNGSSSLPPALAALLKTNGNAQTNSNSNSNLGIGGNTKPDVTSGQAPGQGDLNSLLALLAQGPQSGAYQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LYZ4</accession>
    <name>A0A2X0LYZ4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C017g08324 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C017g08324</name>
        <name evidence="2" type="ORF">BQ5605_C017G08324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY19808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY19808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="264" mass="29300" checksum="C18AE7A50D1BA777" modified="2018-09-12" version="1">MNMTIAELLAFDVAPADASLHIELSKDELTHYSTLSSTRGPTSSCYTRGRPMESSDPTRGEAGVGVSNTEEGCTLTTNEIQKNAYIEDGRIQEKLPERDKQYGALAQHYPHFGSLDGAVTAATPLEIGSLICFGLKCGMHSLSCDQTVYGEEALSIGIVTTNHSNQDTLASLVLLSNVVVQELRFIEKAYYFIHIDGTMPFRMIDGRQQKGSLTTKQQASQQSKEGLFEAWSHAQHQPKRRAPQATFDRPPRARKRLERVFEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M0G0</accession>
    <name>A0A2X0M0G0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C003g02028 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C003g02028</name>
        <name evidence="5" type="ORF">BQ5605_C003G02028</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY38429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="796604.A0A2X0M0G0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:intracellular protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990229">
        <property type="term" value="C:iron-sulfur cluster assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Mitotic spindle-associated mmxd complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039796">
        <property type="entry name" value="MIP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIP18 family-like" evidence="4">
        <location>
            <begin position="87"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY38429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="208" mass="22686" checksum="FD1AD17F22F76318" modified="2018-09-12" version="1">MSFSSGPDNANPVVHTTPSSRRCRSLARVRHLELDDDNDWLTPNGASGATSPPSTLDTIVARVEHMPGSTEAIDSDEIFGQPLSSNLIRSITDPEHPLTLEQLAVVSAPQIHVTDGARPSVRVEFTPTIPHCSMATLIGLSLRVRLLRSLPERFKVDIKVKEGSHQSENAVNKQLNDKERVAAALENSHLVSVVQQCLSTADYRGRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M0H9</accession>
    <name>A0A2X0M0H9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C018g08609 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C018g08609</name>
        <name evidence="6" type="ORF">BQ5605_C018G08609</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY25399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M0H9"/>
    <dbReference type="STRING" id="796604.A0A2X0M0H9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045159">
        <property type="entry name" value="DCAF7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019194">
        <property type="entry name" value="Tscrpt_elong_fac_Eaf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19919">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09816">
        <property type="entry name" value="EAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Transcription elongation factor Eaf N-terminal" evidence="5">
        <location>
            <begin position="22"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="938"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="143"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="276"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="520"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="751"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="986"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1083"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1119"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="210"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="288"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="305"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="415"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="538"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="576"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="586"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="752"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="997"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1087"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1119"/>
            <end position="1144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY25399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1191" mass="122177" checksum="252DB620FD4A33B2" modified="2018-09-12" version="1">MAAAAAASSTSTTATVASDTLHDIHLGASFLRRHDDDALVSLRYTQKPVSLGSAATGLLWVHPSSNANSTPPGTRNVLAAFPIETSTSSALGGSGQQRTGEVRFTGQVQNSKDVDCVLVWDEQLQSFSLERLDSSVRLALDRSSAPHPYPTPDPTQPYHPLASNSAPTTTKRRKINSNGASTASSSSSSDEGTKPLSLASRAKHLLAGTDRGGGGKGSGSGSDTGRLNTPNASAGRSRTVSANAALPSSNRVANHRGHSKLAEVEDFGSVYLSDNSSRKVSSGLVLPNKNNNGSSTSGQDRTIQSSPIKPSSSSSTGLMSSPGAAPPSNTMQRSAAKESPRIVPPPIDLIPAPGSANTTARAAPPSRPTAASKRPTLPPAPPGPGQKGSKSTLPPAAMKRPVAAMKSVPSRIDVSDDSDGEDASSDEDDDDDDDDDDEDDSDEDGSDEEEDDDAAIPEGYLATPGQVFAGHLAMRESNSLQGYATLGGGIAGGKGAGMVQGGELRGRSSMVQAIASGAMTRVSSAPPLSKSRDKQAMNVASSTVPTTSRSSNVAKDPSGSGSGSGNDASMIPGPPRGVGGIGKGKGAPPKAARAGKSVVVPPPPPPQRAQKGLPRTVQRGLWRPIRPIPKVRRIELGGKTGVMGCCPFFLFLEERWVTMTPTVLDYHSDCPTFSLAFSPLGTTTSTLKLAVGSYNESRAHTSPTTAFSSAATTLSGLTSASSGSAFEDINNLTIISLDPAYLDLEDVHPNDFDSSTASSQHGSSNNHDHNSLSIEGYVRARNGQLLPSQSAFLTTARAPMPYPPSAISFSPASLSNQLQSSSMGTKGETTREMIASSSECLRLWDLVANDGEMVGANSSAGTGSGSAGFVGAMGRRASAGPQTRLVERAKLANSKQEYSAPLTSFSWSTLEPTHIVTSSIDTTCTVWDISTRVPVTQLIAHDREVYDVAWSPASRDVFASVGADGSVRMFDLRSLEHSTILYEATSPSTLGSSSNKNGGGGGGGGRTSSNQSHGSPKPGSKTPLPPSPLLRLAFSPTSPTYLSIVHADSTHVQILDTRSPGVPAMEVRGHAASVNGMAWGGSTLHSSGGGGGGGGGDSAGPGWLATCSDDSTLLLWDLSTSPTPPTTSSTRGASTTSGSATLTGPKMITTPSLSYSAPGEINAVAWGGGGEWLAAGCGKTVRCLKVEGGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M117</accession>
    <name>A0A2X0M117_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C121g13295 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C121g13295</name>
        <name evidence="2" type="ORF">BQ5605_C121G13295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000027">
        <property type="protein sequence ID" value="SGY27672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M117"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026960">
        <property type="entry name" value="RVT-Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13966">
        <property type="entry name" value="zf-RVT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY27672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="755" mass="85085" checksum="C30E26494BA82FEE" modified="2018-09-12" version="1">MTASLAEGLVRLLPKNKPGANLKSLGAYRPITLRETTYKVLSKVLVARLNGVLGELLPPAQHGFMPSRRSADAGSHLTLLLGKTQQSAYDRVDHAWIFDVFEAFGFGERFISLLRALYDPETLGVRYLINGFPTELVRLLCGLGQGDPLSCPVWNITFQPFLDALVRRGIALDLQKVWPGGPRAQLTHLAFADDAVVVVESPAALSKLETLSQTWYEATNGKTNTDKTLALPTVQEGESFKWCGYAFFRHGDSKLFWTHVLDRIKAKTRAAGDRTLSPSGKVFYANAHIISTVLHVLSFDIPPQWFIKAAETALTDFVWGGAGRNTVARDFVFQAREDGGLGLISIGDIVHSVALRFWDAVAGSNEAIWAPLARESWRSLVAATRDFSPWGFFSSTARVEKLYRDSTRWGAVVAAARVTVPTIKSELLTLPELLSLPPRLPSLYAEGAKHAYDDADAVAKFAQIADLYWRDEGKGWALVGHRRGFWQHSKEPALQHEHVWSRVGQLLKAKALLPKTALRPARIPLKEAPRPRCFNFFGLTRPFTIRKLRRLVNVVRFPGREDRVKRFRDGTSQSDRKRFWRWLHDRFASAVEQDTHWRLMYDVTPTRKRQHTQGHASSPTCLFCGNDAAVIETVSHYFFECAYSTSFWGGVLRILFDKLGIEDTDVDPSTFTPEQLTMGLPLLRGRGRTTSRWMWVRLACAIGFQRLHLLRWRVHQRFELDKVVAPPSLPSALRAFERDFLSRAGFVPGARDWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M2E4</accession>
    <name>A0A2X0M2E4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BQ5605_C002g01351 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C002g01351</name>
        <name evidence="11" type="ORF">BQ5605_C002G01351</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY32337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M2E4"/>
    <dbReference type="STRING" id="796604.A0A2X0M2E4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="8">
        <location>
            <begin position="6"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase RNase H-like" evidence="9">
        <location>
            <begin position="236"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase zinc-binding" evidence="10">
        <location>
            <begin position="553"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="399"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="760"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="427"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY32337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="861" mass="97380" checksum="0BBF4E9E464A912F" modified="2018-09-12" version="1">MQPYNDTFQQIRIADEDVHKTAFATPHGICHTRVAQQGDRNSTVTLHRLVHHVFEGLLGTSMRAYADDLWVLSETWSEHKQNVEEMLRRCLTHDFRIPISKIKIATGTRDSLGREIRQGQIGMSASKTECIVNMPPPTNKKELQRFLGTVEYNVRFLPHLADVAAPLTALTGTAEWRWSKPCDLAYEAVKKLVADNAKLACIVESKLAPKGSKPKHLTSPPSYDDLCPKNDEKGENLFLHTDASMTGTGAMLAVGTHWWNSRPVGFYSRKFTDTQKNYPVHEQEMLAVMDGLKHFDNKLRGRQFTVVTDNSTLASFLTSKNLRPRQIRMYIFFSEFDFDIKYVKGEHNVVPDWLSRQYESDDRHPHREVTYLEELPELRRIEFSSDLYAYLQGPEIRRTDITDAESRPLRTRAQPVRFAQESFPAGKRQRQGKSKGKGKGKVRGKSNAPAPPKARPNAPKESAFDRVMADRAAEKWDTLDEVELDLDPLHKSEFTTAIENGLRSDAFFKRILSNIEKFDQYKVDTVDGKTLLFHRSDGALRLCVPIAHVRGRSVREIILQHAHTIVGHGAALRVIYWLRDRFWWPTLSKDVDSYCRTCPSCQACKPSTQSPMGYLHSMPIPSKPYEEIAMDFQGPFPTATSHLGPVDALFNVIDVLTGEVIMLPCDFTDFWRTLHAALGTTLAMSSAYHPQTNGKIERIHRDINALMRQIVSEEQTDWPSHIPFVQFTLNNALNKSSGFSAFEISRIRTPETIPSWVRATSEHPADPHQGANSAGPQRQRAPPRSHRPDGAIWTPNRGCARPARGSAPAAIEVLGDHAELAHGALSQPQVGAQIRRPVRRACLRPYDFNVHPRPSSEVHKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M2G1</accession>
    <name>A0A2X0M2G1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C001g00163 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C001g00163</name>
        <name evidence="5" type="ORF">BQ5605_C001G00163</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the DapA family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY44477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M2G1"/>
    <dbReference type="STRING" id="796604.A0A2X0M2G1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF66">
        <property type="entry name" value="4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="3">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY44477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="315" mass="32995" checksum="E7E3689C256B85E6" modified="2018-09-12" version="1">MPHATTKSFPRGVYAPLNTFFLPDSQDLDIPTFKKHAGNIASAGVGLVALGSMGEAVHLDHTERNTIVKAAREALDENNLSSVPLIIGTAASSTRETIELTREAAEAGADYAMVISPGYFVGALSKDALKTYFAEVAAASPIPIIIYNYPGASAGIDLDTDTIIAMAKGSPNIVGIKLTCGSVGKLTRLVNLRPDFLVLGGFVDFLAPAMLLNGAGCITGLGNVAPKSCMKLFNLTESGLNGSAKDLAAAKDLQVIVSNGDWTMCKVGIAGSKYVLSKLHGYGGEPRRPILPFSGDGEKLLADLKPLLDYENSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M2H3</accession>
    <name>A0A2X0M2H3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
            <shortName evidence="12">DHBP synthase</shortName>
            <ecNumber evidence="3 12">4.1.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C002g01381</name>
        <name evidence="14" type="ORF">BQ5605_C002G01381</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="12">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the DHBP synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="3 12"/>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY32558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M2H3"/>
    <dbReference type="STRING" id="796604.A0A2X0M2H3"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000002">
        <property type="entry name" value="3,4-dihydroxy-2-butanone 4-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00180">
        <property type="entry name" value="RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF18">
        <property type="entry name" value="3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0318">Glutathionylation</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 12" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGY32558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="272" mass="29223" checksum="4E54BB2074F2C418" modified="2018-09-12" version="1">MSTSTSARTKKAPTRVRNTSAGHGHGATPPASTTSSSSATALATASASASASASSAPSTQGAEEHWQLDSIEDALVDIRRGEFVVVVDDMDRENEGDLIIAAHNISTEQMAWLIRHSSGYICICLPAQRLEELDIKMMVEDNQDKNKTAYTVTVDYRHGTTTGISAHDRALTAVKLTDPSSTAADFSRPGHLVPLRAVDGGVLARKGHTEASIDLCRLAGLPPAGIICELVKADDPMGSMARRDDCFKFARDWGLKMISIEQIEQYRKQKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M470</accession>
    <name>A0A2X0M470_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C001g00723 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C001g00723</name>
        <name evidence="3" type="ORF">BQ5605_C001G00723</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY48988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M470"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY48988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="551" mass="61366" checksum="66294DF03E29DA92" modified="2018-09-12" version="1">MMSNPYTAMIESLHAQVYRTPSPGFEARMIVLSVINVLLVYLVLTQYERTKAVTLNAGGEESYRMKQRTFWVFRRVDRLSDKTPLVIPNHRTVGISFLLMVGISSIGLCIDSVRVWIYQHSMKSSFAWRAFSMTPMFEHGWILVWANLTTFLMTTDQALSVTVPSWLVNAFFILVFIAGGTMGITANAYYTHKDAQFWNAYVALITQLKSNEAAYPDLPSVASGSAVEQVAAVQAAYIAYWKSGAYTYGPCVIMAVAILIVNAAGLSLCRVMQRQIDFNKDQLLAAISPGSRIEGPANLEPHVDAAESRPRNLDKMIRWIDMATFNPSKSSLKASDLRKMCMGRANIYQREKARTIIVLARARLELMLFSMCAASLSFGVVGTLMYLAIVSNTLAIVNGPWGIFESSVYFGTWSYPSLLLLVLSILIYQAYRYRQPQGSARLTRVAASQISTSGIISTSSVRGAKEADDRRSFFVTATQLSAPSVSQPASSTDQRPRTDSAGPRRKEFGISRPFPNLWPRAKTSTRGKKPRVLEVNLVVDRVVRRRAKMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-10-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M4S5</accession>
    <name>A0A2X0M4S5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C003g02123 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C003g02123</name>
        <name evidence="4" type="ORF">BQ5605_C003G02123</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M4S5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003877">
        <property type="term" value="F:ATP:ADP adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009163">
        <property type="entry name" value="Ap4A_phos1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043171">
        <property type="entry name" value="Ap4A_phos1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045759">
        <property type="entry name" value="Ap4A_phos1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019200">
        <property type="entry name" value="ATP_adenylylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420">
        <property type="entry name" value="AP-4-A PHOSPHORYLASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19327">
        <property type="entry name" value="Ap4A_phos_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09830">
        <property type="entry name" value="ATP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ap4A phosphorylase 1/2 N-terminal" evidence="3">
        <location>
            <begin position="100"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="ATP adenylyltransferase C-terminal" evidence="2">
        <location>
            <begin position="203"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY39011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="333" mass="37074" checksum="8783751712AA8B53" modified="2018-09-12" version="1">MSETPSSLPWRIQSSFRSAVALKQVNLFRSSEIVRIDDAPPTFPNQLVHICPDLAHKPSAPPKTPDLSKVGKRDPLQGPEYGPGEKVQDFECGGVSYSIVHNLHALMEEHGMIVPQFGESTPFRPQTSDLIDSDLEAAYSLTQQYADDGREIICFFNGGPLAGASQPHLHIQFCPFQLSTPPAPELLARAIGPVSEDKPTKLNIPWIHYIIPIPPSPTTATLSTLYHRLLKTNRDYLEAHGKSDRTSYNLFITQKFMHLVPRTKRLIRFERKSSEGKTEEVNFSVNGLVILGLWHVQDSNTRAELLQFGLERGLRSCCVANGDYAAANYEKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M5B0</accession>
    <name>A0A2X0M5B0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C003g02494 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C003g02494</name>
        <name evidence="9" type="ORF">BQ5605_C003G02494</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY41308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M5B0"/>
    <dbReference type="STRING" id="796604.A0A2X0M5B0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12241">
        <property type="entry name" value="RRM_SF3B14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000286">
        <property type="entry name" value="Putative pre-mRNA branch site protein p14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034150">
        <property type="entry name" value="SF3B6_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF17">
        <property type="entry name" value="RNA-BINDING PROTEIN PIN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="17"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY41308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="124" mass="14186" checksum="CEEE1B9FD00AE005" modified="2018-09-12" version="1">MSSSSNAGVKLPPDVNRILWVKNLNYKTKGDDLYDLFGKYGAIRQIRLGNEQKTRGTAFVVYEDVHDAKQAFDHLNGFHLQERYLVVLYHQAARQASKTDLARREKELAELKKLHQIADEDANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M692</accession>
    <name>A0A2X0M692_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C006g04189 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C006g04189</name>
        <name evidence="3" type="ORF">BQ5605_C006G04189</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY56884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M692"/>
    <dbReference type="STRING" id="796604.A0A2X0M692"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="6"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY56884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="355" mass="40440" checksum="162649AA4BD80145" modified="2018-09-12" version="1">MYVNVPKQQPREVALDFVGPLPKSQGFDLLLTITDGLSGYTRLIPSLAADTAKDIAERFHEGWHRFFGPPTRIVSDRDKLFTSHFWRAYHNLMGTQLAMSTSFHPETDGRSERTNETAIQALRAVVNKQQNNWVRHLVNIEFAINASVNASTNKLPFEVVLGRSPSLLPTSLNRPDLPNVPAAKDLIAERKAVLAEVRDALAVAKVRQAEQVNRHRRPEPDIAVGDFVMVDTRDRRLRFKTGHRKSAKLFDRFEGPYKVIAANVATSNYTLQLSEGDRSHPMFHISKLRPYRANDPNLFPNREPARTKPVIVDGHEEWVVREILEETTRGGKRYHVWWGGYPQHEATMNKRLTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M827</accession>
    <name>A0A2X0M827_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C007g04847 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C007g04847</name>
        <name evidence="3" type="ORF">BQ5605_C007G04847</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY63915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M827"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026960">
        <property type="entry name" value="RVT-Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13966">
        <property type="entry name" value="zf-RVT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase zinc-binding" evidence="2">
        <location>
            <begin position="341"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY63915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="501" mass="57064" checksum="493C7FBDF1BF9955" modified="2018-09-12" version="1">MSRMSENRAVLLQVSTRKLTSRQRCACDSPRLVGTNDDPEMINKRRRTAGPGVEPGKTALTDFVWGGAGRNTVARDFVFQAREDGGLGLISIGDIVHSVALRFWDAVAGSNEAIWAPLARESWRSLVAATRDFSPWGFFSSTARVEKLYRDSTRWGAVVAAARVTVPTIKSELLTLPELLSLPPRLPSLYAEGAKHAYDDADAVAKFAQIADLYWRDEGKGWALVGHRRGFWQHSKEPALQHEHVWSRVGQLLKAKALLPKTALRPARIPLKEAPRPRCFNFFGLTRPFTIRKLRRLVNVVRFPGREDRVKRFRDGTSQSDRKRFWRWLHDRFASAVEQDTHWRLMYDVTPTRKRQHTQGHASSPTCLFCGNDAAVIETVSHYFFECAYSTSFWGGVLRILFDKLGIEDTDVDPSTFTPEQLTMGLPLLRGRGRTTSRWMWVRLACAIGFQRLHLLRWRVHQRFELDKVVAPPSLPSALRAFERDFLSRAGFVPGARDWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M978</accession>
    <name>A0A2X0M978_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">18S rRNA factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C006g04185</name>
        <name evidence="7" type="ORF">BQ5605_C006G04185</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF2/ABP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY56872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M978"/>
    <dbReference type="STRING" id="796604.A0A2X0M978"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034462">
        <property type="term" value="P:small-subunit processome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12263">
        <property type="entry name" value="RRM_ABT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039119">
        <property type="entry name" value="ABT1/Esf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034353">
        <property type="entry name" value="ABT1/ESF2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311:SF7">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="257"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="315"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY56872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="343" mass="37871" checksum="5838D8D3EB622194" modified="2018-09-12" version="1">MSTTQPATKKHRKTKSQTTPQATGEPSQPIASTSTSASAPADDPRFAALFPADDDDEDRDPSNNLTPRSPSPNSFPKQAPLPSHLLPKSASDSNRPSPGLIYLSRIPPGMGPSKVKHVLSNYGNVGRIYLVKIDSQQAQPSSTQKRQNKHGNGHEKHQSHRFKEGWVEFEDKRVARSVAEMLNANTIGGKKGTPWRDDVWTMKYLPRYRWDLLSEQVALERATQTSFLRFHLQHSKTEQEAYLGAVEKARVGQKIKEKRQMQGTLEEKEEVAGKKRKGEGEGDVSSGSGPASMVGEGEEGRKRLYRQRQLVDVADKVKGHSKGVGQGGKGTQGDLDDVLNKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M9F1</accession>
    <name>A0A2X0M9F1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g03854 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g03854</name>
        <name evidence="2" type="ORF">BQ5605_C006G03854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY54215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M9F1"/>
    <dbReference type="STRING" id="796604.A0A2X0M9F1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY54215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="262" mass="28687" checksum="20D635D40DB4E5F3" modified="2018-09-12" version="1">MELRSEIKESIDSLSNESINRVQRLTVEHRIAVDFGVPSSLDNMTEDEAVALALMLLAEEEEARWFTESATSSAVNSPAFEPIPEELLDMEGMSLDELPEVYYKRPSHLFGNRRPSSSLVHDWDNDDDDDNNDDDKDHSSSPSISASRRSTSFTWRLASHSPQHALPSFSSYHLSSTSPHAKVQVSPRLGPTYDLATNQGYPPSGFVPDMSADLWPVALSSMSHSPTPSSKSNVSLTPSPAPATPASSTMTKRGWNVVARAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MAQ5</accession>
    <name>A0A2X0MAQ5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein PBN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C005g03402</name>
        <name evidence="11" type="ORF">BQ5605_C005G03402</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase GPI14.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PIGX family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY75135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MAQ5"/>
    <dbReference type="STRING" id="796604.A0A2X0MAQ5"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013233">
        <property type="entry name" value="PIG-X/PBN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040039">
        <property type="entry name" value="PIGX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28650">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS X PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28650:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS X PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08320">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00780">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 10" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY75135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="270" mass="30076" checksum="F4FEE79071E498A9" modified="2018-09-12" version="1">MSWYNTTIAPSSGFHPIVTLLIHLAASEQRQRAIEQGCSLWTHLDLSPSWVLDRYQLAQLHHEGRLGSYTDSTGEGQDESFQVVGEDDLEGPVTKAGGVQALLRLQDPKRTKTEEQLEFDVQIPLHLRYQTPVERRFEQGKRADVVSVQLQAPAVFWKCPPSNKAIRRCPPAPALSAFPSPVSSTNSYHYLHPKPLDLGASYSHASSCAQPRLPNLGVSIATGVSSDLPFVDFVNFIAIWLGTIWIASSAYKWQRRNSKSFKPAANKRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MB51</accession>
    <name>A0A2X0MB51_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C005g03522 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C005g03522</name>
        <name evidence="3" type="ORF">BQ5605_C005G03522</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY76857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MB51"/>
    <dbReference type="STRING" id="796604.A0A2X0MB51"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF1">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="2">
        <location>
            <begin position="250"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY76857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="363" mass="39371" checksum="623037151F1C34FC" modified="2018-09-12" version="1">MSARRNATLFGPSMVRPHALRPQLFSGNDPEARAQLSATSTSSHKLRARSLATSSHPFPSTSTSSPSSTSSRFAPRRPSSSRTFLSLATGLVLGSALALTLPRPRLLSLIFPNPTPLPHAADSEEGRLETQRIEKELQALPIVKQLREAQVPAAQGYANPLIAQDVFPTHVETSPTGIADRAPPRDSSLAPKYRESRPYAAANAGPHSLSGFTLKGPSKFAIPPLAFTSKDNKEAVFLMHLGRGLCGHEGVVHGGLLATVLDESLAWTVKIELYSWVISQALQLLPSNIGVTATLSLSYKKPTFADQFVVIRTEFVRQEGRKVWVKGQIEDLEGMVLVQAEALFVEPKMAKFLSSSSVREHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MBQ5</accession>
    <name>A0A2X0MBQ5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C008g04996 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C008g04996</name>
        <name evidence="2" type="ORF">BQ5605_C008G04996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY78940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MBQ5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021842">
        <property type="entry name" value="DUF3435"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535">
        <property type="entry name" value="FLUG DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535:SF3">
        <property type="entry name" value="FLUG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11917">
        <property type="entry name" value="DUF3435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY78940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="353" mass="38475" checksum="37449B86B02DA4BC" modified="2018-09-12" version="1">MDGVTATKLEKKNKSLYISTSFHPTLAPFSPCWQSSSRTTPLRSPPTSTASPHCASTSPSPSLRPGVLDRYVFRASERGNTSTTRGTPCGCEWFGRTLQALGTALGWVVTHTLYAWRRFPANAINVPEVTLAERRLLMAHSAESTAYERYYQSHRTKADTRALVGDRPENRALLTAVNVAEVIADLPMACFPAVRTLRNTGFGVTVAATSSTTDTHDPICSGLDWAAKALPRRDAVATARGYNRSAQALRKRVEELAEVRFVKNISAHTANAQLRVLRLFVHFVARVKETSVSDTITKFFIPGVATPIPDSLVQALMEDATVILGWGTPARRPSRHRACASTTGPPSPPPRPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MBT6</accession>
    <name>A0A2X0MBT6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">endo-polygalacturonase</fullName>
            <ecNumber evidence="2">3.2.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C007g04674</name>
        <name evidence="14" type="ORF">BQ5605_C007G04674</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(1,4-alpha-D-galacturonosyl)n+m + H2O = (1,4-alpha-D-galacturonosyl)n + (1,4-alpha-D-galacturonosyl)m.</text>
            <dbReference type="EC" id="3.2.1.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.15" evidence="2"/>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY62288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MBT6"/>
    <dbReference type="STRING" id="796604.A0A2X0MBT6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050434">
        <property type="entry name" value="Glycosyl_hydrlase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884:SF1">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015970746" description="endo-polygalacturonase" evidence="13">
        <location>
            <begin position="19"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="362"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="377"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="423"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGY62288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="461" mass="49160" checksum="8E9954E1731DE6F2" modified="2018-09-12" version="1">MLCMSSTLLLLLPTLALASKSSGSKSAPGAGCTGTISSLDDVSAALKCQTININSFTIPGGKTLNLKSSLDNVVINLLGDLVFEVEYWRGNLMIVGGKKFQFNGNGHAINANGQEYWDNKVSGTGKLKPSPTLHIIGGGLVQDLTILNTPAQAVSIQNSEPLLVRNVLVDDRAGDALGRNTDGFDVSSSTGLTIDNCTVYNQDDCIALNSANNTAINNVNCYNGHGISIGSMQSNQQVTNVRVENSNIVNSEQCIRVKAFPNLKNSLVQKVRYSGNTCTDYQEHAKVDTKTSLAQVPSTEMQINDIEFTGTNNLFEVEKTAWRFGGTCALGKCNRWNFESLVIKGGAPGVFLNTPIDDFVHSSSGSEGSKPARHPAPGDGSTDSSKSPDPSSHDKSGNGTAGSPADPNTGSTPLATPLPKTHQNPKSKHHGHHQGHGSHKHTHRFLRLAKRRLEDIAYQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MC01</accession>
    <name>A0A2X0MC01_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C010g06212 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C010g06212</name>
        <name evidence="2" type="ORF">BQ5605_C010G06212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MC01"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY14507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="237" mass="24891" checksum="7404116CD47D7F3B" modified="2018-09-12" version="1">MRLALAKDPIDETLPDALRCRLLLAGEGVVAKDESSVLVDESEVVDAERTGWYNMGAMGVIDVIVVSSPEAQSPFSAVPLVDAKGLFELEEVDDASLCALISAAVSVSAPETFGSGALCRGRSTTEDGADTVRSRSLSVDDELLHLCRAGVRCARSISKVAVEAELETVAAESASPRDEVEAFKVGEAKGKVDCSVAPNHALTEDGSDSAFCTDDEEEETFLGSGGTLDPWLLDPDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MC87</accession>
    <name>A0A2X0MC87_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C004g02839 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C004g02839</name>
        <name evidence="4" type="ORF">BQ5605_C004G02839</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY68016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MC87"/>
    <dbReference type="STRING" id="796604.A0A2X0MC87"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF134">
        <property type="entry name" value="RHO-TYPE GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="462"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="314"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="655"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="790"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="663"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY68016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="819" mass="90361" checksum="3464A30669E01582" modified="2018-09-12" version="1">MTGLITDESAHHLLQREVETHLNFFKRRQEIEAKYVHDLREVMRTDRPQVIVDHIRFAHRLGHKQLALKEVHTDDKDRLAALVPEAWRRAAQLIRDNTLLESQTHAASAEGLSKMVKNLSEFRDNKERSRRRIRDELKDNAHADYKVTVARLRKTYERKVEEVQAHESEERERERHEQHQLSLTHSPSYDYVPAQSEHWAAGAEPSGSSSNVHAHGGPKTRERADSSTSNRASHENVLGDPSSTSHMVLGSPPGPGASPVFVSGAGSSHAPSAYRDPPSSSKGGNVFEQIAKRDWSGEKHRINSLARAVGNLAKGNDAGGGNNGGLPSKSGSVRGQKARQISTKLKREAEQADRDYRDGVFRLETLRLHRMRLQMSAQQFLKEYAIEYSATLKDICTSVPAIARLLRSGRDGADTPPPGALVIEPVADGEKFAMMLRAPVPDPPVYYVNYFVGECRSLLFGVSLTDYHSTNPTRLVPLIVQKCIEAVDHSGLQIEGIYRISGKVATVQQIIHEIERDEESFAFRPNDDPAMVGGVLKLYLRQLPFPLFPVTAADRSTYSADFIKDPDACILALARRIRRLGLPNQATLKALCEHLARVVSFESVNKMTASNLGTIFAPVVFGEEEAATLEAAKRNDHMMDILILNHVRIFDGLPAESGKPRSRGASLSSGSAAPPPPSMHAASEQLAHLSVNERHEDEHSMERVIPTSASQAMENGGSYDSVLRLYQDTTTSLLPHERPRSSQATSSPLARHHFETVHPPILLPTSPTLNITAPSHLMDSVDQVALSSSSVNDLSAPSPPLSAALGRHVSVPDEDPQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MC99</accession>
    <name>A0A2X0MC99_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C004g02849 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C004g02849</name>
        <name evidence="3" type="ORF">BQ5605_C004G02849</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY68097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MC99"/>
    <dbReference type="STRING" id="796604.A0A2X0MC99"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="650"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="763"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="671"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="782"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="832"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY68097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="858" mass="93938" checksum="E72304401E8009C8" modified="2018-09-12" version="1">MWKRTSGLVTNELEASASTLQESTDNNGELIVSEACATYLVSVLTAAWLENEQGLDELTLSPPSFQNEPIEWIARFKISSMTLTIFQIWMLVILGVAWYHASSSHLGAVALSQTLVSCFAIAQAAFTYEHYTSFASGILLGPCSLGQPLIPDFWSLMVKSQIAVAVLQLFGSVAIAVFAVNFANVRLRWPSFRECNLSSLRSWTFMQPHGHSGASNEPSQHARLLVSSFELLSTSSIFFVIAFQAVWLRETIHRPSPAFDFAPNWLGVPEQIGVGVLMVLGTYVMTMGQVGLRFRFRSVMVLSLLGNVAVLVHTSCLLSQSTFRVVQASSSFLSFLLVISTALVLLTFVLGTATTFSRPVWSSIGTDGSEGEFTSVHAEFQKPVLTPTLTRTPLSWPVTQSDSSYDDGDAKFSDLHHSTAAPNDLSSTEIVDYRRPKPGQAHVQSHIFNRPPSTSYASNHPRHSRLSSTSTINTTGKWKESIFGQQRSRSMSLELATSRIIPLRSLGSQTLVHIEAPATQSLRSERMTSASERGTILAMANEDLIDEDKDETDLFRQVAPRRLRNPSKASIDVPMPAISDEDTLGVGGDDPFRPVTPRRLRQPSVPLDAEDAEDAEDADAIVAGEVAVRSSARGVDPFKWTTAEPFATTTASKDEFSTHSKITPESGLILSPTQATPSSPSPTRSVRAPKGPPTSSAVPIPNLKFPLSHLSLSDFLFQTPLNAPTPIPVPVPILKITDAQDCRGHGSEHDVPLRPLPQAQIYDRSKTHRVRSAVQQGGQVKSSDERPFTQPSKEHSTMGYKPLQDASIQLHQEDRANSKSSATPTPLGPEPTGRRESVLDRPHPLVYERWTVNWPALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MCR8</accession>
    <name>A0A2X0MCR8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C004g02999 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C004g02999</name>
        <name evidence="2" type="ORF">BQ5605_C004G02999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY69335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MCR8"/>
    <dbReference type="STRING" id="796604.A0A2X0MCR8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37327">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37327:SF1">
        <property type="entry name" value="MICROTUBULE INTERACTING AND TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="693"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="937"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="705"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="725"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="774"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="795"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="816"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="877"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="937"/>
            <end position="948"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY69335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1194" mass="126420" checksum="2E60EEB76D2AB1EB" modified="2018-09-12" version="1">MLEGASYSSLSSRGTNAINVDDDDDDPTTAGRAPASTTASVSRYNGIRPGITTTAGPSSFSPPSSAPPTAPLPVPFPSSGSGMATPSRAPNGPGSALRQRGESSPVTSRHTARPSTSTTASSSSHSHGNNSLGDDPLLSKPFVRRGSSTAAEGLGSATASSTSRRAEHPFIPTTSSDQWATSREQYDRAYSNGKGPATEARPARPQHYVEPFGNHDHNSAGAPIASTSAPSNTGAVASSSSSRSQYLNASSASSAAPNSSKSVLTIALQRAQSAVLLDSANNVPAAISAYSSSVRLLKEVMARVEDGARRDREKLNERGGDRYVVRTGETEEDAQKRIARIERKERAKMDEARRLKVIHDTYEDRIRMLQSIELEQAGATPKPVVEESGSAPRAPTRTEQSATPYITAPPMVSRRSQNRSISSLETVSIPPATFATSNQASAPSDDAFSRQPLTSLDETDTTPKLALEPFRKPSPAITHSNGPTAGGSRRPSLSPERLRNHHITTERPVQLGRSASSDNLGIQSHQRFSSNGSDDSDDRVPVTARETASGWPTQPENGTARERETTLAPASYGAQSRHSPTPGAIRTGVSPQPSQYAFQPHELRRTASDQAAPSASPDLSSWSNETRAALSSAAVTSPLNEATKRMTGVRTSSLLAAGYLPFSEEVPRLIDARVTLARGTIMASGGTGIAVSNSASAKRRENASPLVNDSTTTGAISQRRRSSQAPSPVTGSETTATSAVKASGAHRGTVRDEDSQRDAKNAAAFRGRSDVGPSVSSPSLQSASSASTSFMNDLGPTTASDEGYSNASLPTRLRTHSQPGQRPSLSSFQNQPPVPSIVTVGDRSISSNGPPRMMRKSSVPSPTSSAGPGLGHPPSLVRTNSVSSQGSYSERDAPHRGAPSPFWNYLDTFASSREVLNGASTGRRSIAAVGEFVPSPANASSLEPSSPTVPLAAGGSSSEVGAPGTTPVRRPFYLMRQILQTIETDGAYITPTLYIPHQVWSQAGVKLVAVETKVRMLDLLLTGLEAVDKLGKACWRSEGGRSTCEAAARLTKELESFEGLTEGIQSTLSKKLGYASTGKKVGTNSFSAWSSKLSRSLDRVTNGRSLDHPATYVDSIARVLQQAQCLDVYLVTINERSFPLSEMDERDRAQLALRLKRLSEFFGGMICHFILRDIGMLVDKYVKRAGVWFSENGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MD99</accession>
    <name>A0A2X0MD99_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Coatomer subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">BQ5605_C008g05393</name>
        <name evidence="17" type="ORF">BQ5605_C008G05393</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12 13">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Oligomeric complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Golgi apparatus membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Cytoplasmic vesicle</location>
            <location evidence="13">COPI-coated vesicle membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the COPG family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY80461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MD99"/>
    <dbReference type="STRING" id="796604.A0A2X0MD99"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000071">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1480:FF:000001">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000008">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1480">
        <property type="entry name" value="Coatomer, gamma subunit, appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032154">
        <property type="entry name" value="Coatomer_g_Cpla"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017106">
        <property type="entry name" value="Coatomer_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013040">
        <property type="entry name" value="Coatomer_gsu_app_Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037067">
        <property type="entry name" value="Coatomer_gsu_app_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261:SF0">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16381">
        <property type="entry name" value="Coatomer_g_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08752">
        <property type="entry name" value="COP-gamma_platf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037093">
        <property type="entry name" value="Coatomer_gamma_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 13" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="14">
        <location>
            <begin position="19"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer gamma subunit appendage Ig-like subdomain" evidence="15">
        <location>
            <begin position="682"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer subunit gamma C-terminal" evidence="16">
        <location>
            <begin position="831"/>
            <end position="943"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR037093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="SGY80461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="945" mass="103109" checksum="AA2110AF03AB01D9" modified="2018-09-12" version="1">MSAYKKDEESGVSQFFQDKTTVIQEARVFNETPISPRKCRILLTKIVYLLNVGETFGSQEATTLFFGVTKLFQHKDSALRQMVYLVIKELSGIAEDVIMVTSSIMKDMQPNLEVIYRPNAIRALCRIIDGSMIVGVERFFKAAIVDRNSSIASAALVSAYHLHSVARDVVKRWANEAQEAINNKGNSGGAYGGAGQAGYQAVQSASAITQYHALGLLYLIRQGDRMATIKMIQQLSANKGSGGGSLRSPYAICMLIRFAAKVMEEDPNVHRQMYELLDGYLKHKSDMINYEAARAICEMQNVTAADLFRPIAGESHRIRPLALGLGIYTDVNSGVAVLQLFLTSPKATLKFAAMRTLARLAQTHPGAVQTCNLDMEKLINDENRSVATFAITTLLKTGNEASVDRLMKQISAFMSEISDEFKVIVVNAIRSLCLKFPAKQSTMLAFLSGVLRDEGGYEFKRAVVEAIFDMIKFISDSKEAALAQLCEFIEDCEFTKLSVRILHLLGVEGPKTPQPSKYIRYIYNRVILENAIVRAAAVSSLAKFGVNVADPSVKKSVEVLLTRCLDDVDDEVRDRAAFNLKLMKDDPLATTFVRDDSTFSLEVLEAKLEKYVADPDASSEPFDLATIPKVSKTQSLQAALRAQSEALSIVATGSAGIESNGGDAHGGANGQPATAAESQSLYASQLAEIPELTGYGPVLRSTAKPLELTERETEYVVTCVKHLFAEHVVFQFNIRNTVDAVVLERVSVLMTPTPETALTEDFIIPIPSLAPSSSGVVYVSFTRSDPNEYAIGTFANALRFVSKELDPESGEPEDEGYDDEYQIEEVDLDAGDYLIPSYAAFQTEWDRLRTAANRTETFALTALDSLKAACDSLVEVFNLEPLGGTEVPSSTSVHTLQLAGIVAGGGGRVLVRARMTYQSGNGVTMELAVRAEKEPAANLIIGALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0ME55</accession>
    <name>A0A2X0ME55_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C131g13369 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C131g13369</name>
        <name evidence="2" type="ORF">BQ5605_C131G13369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000059">
        <property type="protein sequence ID" value="SGY89260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0ME55"/>
    <dbReference type="STRING" id="796604.A0A2X0ME55"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058913">
        <property type="entry name" value="Integrase_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791:SF5">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24764">
        <property type="entry name" value="rva_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase core" evidence="1">
        <location>
            <begin position="119"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY89260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="374" mass="42938" checksum="9B7698672F30FBA1" modified="2018-09-12" version="1">MLVGFSSFVTSVRTNLGTTQIAKLFGVSRWTIRKAIVDQQVRQPFERTRVRTLLPDAELDRLVMEILDHETSLGEILVGGALRARGIDVPREALRASIQRTRPLRRHVHANHPVMRRRYNVAGPNALWHHDGQHALISFGIVIHGFIDGYSHVLAGVRASSNNRASTVLSVFQDAIALYPNVQVAAMMEAVRGLGRGSYLWGTSPHNQRIERFWRALKKSVLNAWLHRFRHLEDEHGLNIELSRHVWLLEFLFLDDINKDLAWCQDVWNNDKLRTEQRSTPNQLFWSGSIQNGGRGIYDENLHIPESTEQAGNENNNMFGEEVRSHVDLHSQRSPFLNNPEGLEALQRRMTERWHASAVDRWLEGLRAMEQLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MEL6</accession>
    <name>A0A2X0MEL6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C005g03641 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C005g03641</name>
        <name evidence="1" type="ORF">BQ5605_C005G03641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MEL6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY77448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="110" mass="12527" checksum="BEA3122C66E70845" modified="2018-09-12" version="1">MDFQQCEAIDRKQESGVSLSLQVPTEAILKKTWGTNASLVKTFIKDTKKTFKHLNKLAAERYTDNDSDEDGPVRHHYFPMLQKWYLFAMPLVQIIPLGGHTASCRTMAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MFY1</accession>
    <name>A0A2X0MFY1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C008g05242 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C008g05242</name>
        <name evidence="2" type="ORF">BQ5605_C008G05242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MFY1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="381"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY79875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="407" mass="46885" checksum="DAE7C329FD1CA1B0" modified="2018-09-12" version="1">MAPRATEGERAWLDIDSHLIDLIRDESGQWRVRCELCNKHYKLPGGYRSFDGPTRAFNPSTVDSRYRCNEAAFELIGTDREVQAKRYRRQLQAKLDMLEAPGKADRARHDEWAAERARRLVMEPKDIMTQDPIPEDVENFDYQVREEIDYVMWPVWDEWAGYKGNGRLPRSLLTVLIHWRNVLFDAYDNQKRKRGGGSARVLKEYRTRIQDFDDILARIFTVPVDIAAEYEELRLFREILSPLYQECQRPLPEDDVYRPFLGKRVPDDYRDQLESEHRTWQAALRPFATTVLVHVPEPPKPPTDADLEPERKKIWDSWIVECAHMWLALSSKQRDAYCWMRKKGSGGEGAASTSGAREEDAISEHSSATGQHSDHGSATGSEAESNLSTLSELTSLSELERGLDTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MGV3</accession>
    <name>A0A2X0MGV3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">(2E,6E)-farnesyl diphosphate synthase</fullName>
            <ecNumber evidence="6">2.5.1.1</ecNumber>
            <ecNumber evidence="5">2.5.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dimethylallyltranstransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Farnesyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Geranyltranstransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">BQ5605_C033g11160</name>
        <name evidence="17" type="ORF">BQ5605_C033G11160</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.1" evidence="6"/>
    <dbReference type="EC" id="2.5.1.10" evidence="5"/>
    <dbReference type="EMBL" id="FQNC01000066">
        <property type="protein sequence ID" value="SGZ01687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MGV3"/>
    <dbReference type="STRING" id="796604.A0A2X0MGV3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:(2E,6E)-farnesyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045337">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000006">
        <property type="entry name" value="Farnesyl pyrophosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039702">
        <property type="entry name" value="FPS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525:SF0">
        <property type="entry name" value="FARNESYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525">
        <property type="entry name" value="FARNESYL-PYROPHOSPHATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01017">
        <property type="entry name" value="Polyprenyl_Transferase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="SGZ01687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="349" mass="39829" checksum="263CE11AFF4C0AF8" modified="2018-09-12" version="1">MSSTASRDKFLSIWPGIRDELVAYLEAQKMPKEATEWFKQNLDHNSPGGKLNRGISVVDTVQILKGSDLTDHEYKQAAILGWCIELLQAYFLVADDMMDQSITRRGQPCWYRVEGVGNIAINDAFMLEAAIYHLLKKYFRSEKYYVDLLELFLETTFQTEMGQLIDLITAPEDSVDLSKFSLDKHHLIVVYKTAFYSFYLPVALAMHMSGVTTESSYKKALDILLPMGEYFQVQDDYLDCYGTPEQIGKIGTDILDNKCSWLINAALAKADDGQRKVLDENYGVKSSESEARVKEVYKQLGLAQAFDEYEAESYKRINAVIETIPEQGGVGLKREVFRAFLEKVYKRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MI60</accession>
    <name>A0A2X0MI60_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C009g05741 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C009g05741</name>
        <name evidence="7" type="ORF">BQ5605_C009G05741</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY85130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MI60"/>
    <dbReference type="STRING" id="796604.A0A2X0MI60"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001763">
        <property type="entry name" value="Ras family gtpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY85130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="199" mass="22487" checksum="0EB4EC16329BD430" modified="2018-09-12" version="1">MRRLGNETRKEYKIVIMGGGGVGKSAITVRFVHSLFVEKYDPTIEDSYRKTMVVDGITCHCDIMDTAGTEQFMALHSMYMKTGDGFVLVFSLSSMESVSELQNIREQIHRIKEAESRIRVPLVLCGNKCDLGAERQVPRDVAVGLSRAWGGVPYYETSARKEINIQEVFEDVVRQMIKAGVGTKYKDRRSRQPKTCVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIZ2</accession>
    <name>A0A2X0MIZ2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C038g11713 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C038g11713</name>
        <name evidence="1" type="ORF">BQ5605_C038G11713</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000061">
        <property type="protein sequence ID" value="SGY92055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIZ2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY92055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="50" mass="5472" checksum="55B350946B43D917" modified="2018-09-12" version="1">MSDSEFKRCLAKNCAIDDTGLNACSRLDQATLCVRQGCPSGHHLDYLNVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJ48</accession>
    <name>A0A2X0MJ48_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C010g05874 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C010g05874</name>
        <name evidence="2" type="ORF">BQ5605_C010G05874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJ48"/>
    <dbReference type="STRING" id="796604.A0A2X0MJ48"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY13482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="228" mass="26432" checksum="BBC142739638C8DC" modified="2018-09-12" version="1">MKDLHGCLTNETESISRQSFETSLKQLGTDYVDSLIMHAPMRTREETRSVWTEFESLVKSGKVREIGISNIYDVDLFDWCFETFEIKPSSIQNRFVEEHLNFCAPILERLAQRVKKGHPMVRLQTFWTLTGNPQILRQLSPPQVLTFPESRARLKTSAQVLYYLLMTARRWPKGMITPLTGTTSKQHMQDDIEVIRAVAESSVGDGWKGEEKEMEDARKLVEKYIWSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJD5</accession>
    <name>A0A2X0MJD5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C036g11472 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C036g11472</name>
        <name evidence="2" type="ORF">BQ5605_C036G11472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000063">
        <property type="protein sequence ID" value="SGY95119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJD5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY95119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="97" mass="10460" checksum="9288B37DC383A0D0" modified="2018-09-12" version="1">MHLKAKINPRDPSGSTAGEQLASPNNNHVNNQSASCLVCLTSAPESLAHFPLSRRLRFSSEPLEPSTGTRSTGVDPLQASTEGRRLVSLMTIPKVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MK83</accession>
    <name>A0A2X0MK83_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C013g07086 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C013g07086</name>
        <name evidence="2" type="ORF">BQ5605_C013G07086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY14753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MK83"/>
    <dbReference type="STRING" id="796604.A0A2X0MK83"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21581">
        <property type="entry name" value="D-ALANYL-D-ALANINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21581:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY14753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="569" mass="61233" checksum="AD7ABD47ECCEB18E" modified="2018-09-12" version="1">MQSYDANERFKVGPIAADAQYALGSAPPSPPPTSIAAPGTHPPPPPPSLSSPYALPHQAQVVSPPLPPLPPPPLHGYSPNPESTPLASSSTAPYSLASSLQQLSGEAAFLPTPRATEYQLQQSLPIASTSNAPDLATASTSPDEDYIPGLMSPHLFVVLPNAHPILFDFCPQTDNLTPLVERYLGPSAPRDLSGADGKGKTVQELIVSRHVKPCIPNSGADVNIASTLQQTARKWRGLAELCHDVIMSSSPEATSFLLGHWLLRLHCLLRLHLVEHFATELLGLIAILPPLVSLTPPPARPTGITPPRFIPVIPFELHVMLATLPALRGDPERSVGNLSVLLKNIRCEMWVCEWRDEHDIAQEWKTRAERIAGMIAAALVEIKAYPSATYVLTAGSRTKPLSSALLPALTRLQLATGDIVGLSMTVAASNTPSKHDRTTRKMLALGKVARGDWADAEADWRALVQEDDRDAEALNNLAVVLLFASRLNETRLNNLRPPDNLAQAINLLAGLFSTKPSTAYASETIIFNYAILLELRTDKSMGAKVELLRGVLSGPGAEDVRSTYLKLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MM57</accession>
    <name>A0A2X0MM57_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g01917 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C003g01917</name>
        <name evidence="1" type="ORF">BQ5605_C003G01917</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY37921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MM57"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY37921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="172" mass="18302" checksum="961B37045C473960" modified="2018-09-12" version="1">MQYRSRGKSSTARFGGVTVAMAGDPKQCLPVTLNGSVRWSDRRVGRKSEATPSRYSTARFGGVTVALAGNPKQCLPVILNGAVRWSVEGSEAMPSRYSTAYFGGVTIPLAGMCPSFKSKTQGSMTNDRLDCNITGNPKQCLPVVPRLGSVESLPVIPKSSPAQIIDACLMEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MN99</accession>
    <name>A0A2X0MN99_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NTF2-related export protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C022g09460</name>
        <name evidence="4" type="ORF">BQ5605_C022G09460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MN99"/>
    <dbReference type="STRING" id="796604.A0A2X0MN99"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000005">
        <property type="entry name" value="Nuclear transport factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045875">
        <property type="entry name" value="NTF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12612">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="3">
        <location>
            <begin position="7"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ22247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="139" mass="15361" checksum="EB00C431499D0224" modified="2018-09-12" version="1">MADINAIAKQFTDFYYQTFDSNRSGLAPLYRDHSMLSFEGQPTSGATAIVEKLVGLPFQTVQHRITTMDAQPASQTEASMIVLVTGQLITGDEANALSFSQTFHLKPAAARELTTPRVLLLKSDGSYYVYNDVFRLVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNI4</accession>
    <name>A0A2X0MNI4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C027g10418 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C027g10418</name>
        <name evidence="4" type="ORF">BQ5605_C027G10418</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S9 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MNI4"/>
    <dbReference type="STRING" id="796604.A0A2X0MNI4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040780">
        <property type="entry name" value="Rpn6_C_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040773">
        <property type="entry name" value="Rpn6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18503">
        <property type="entry name" value="RPN6_C_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18055">
        <property type="entry name" value="RPN6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="216"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ28709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="439" mass="49322" checksum="B662B33EB65A3E40" modified="2018-09-12" version="1">MSSSPKATTSTPARTEQQLRAILDQRVDGPQDDQLLKEKETAIVELGQLYSARQDATALAQLIRDSTWLMQHLAKAKTAKLVRTLLDQLSAIPNSSALQIKVTQENVDWARSEKRIFLKQNLETRLIALYIDNQNYKDALALITTLLRELKKLDDKMVLTEVHLLESRVNHLLANMPKAKAALTSARTAANSIYCPPLLQAQLDMQSGILHAEDKDYKTAFSYFFEALEGLSSQDDPKAPAALKYMLMCKVMLNLPEDVTSIIAGKLAQRYAGPQVDAIKAVAKAHEDRSLSDFERLLKEHRKGRFKGKAVGGQRVFSILIRTVLFDRPELSDDPIIRNHLSALYDTLLEQNLVRIIEPFSRVEISHIAELVGQPVRDVEAKLSQMILDKVFDGILDQGAGCLIVWEEPEVDKTYDATLETLGHISHIVDQLFTRTRSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNV7</accession>
    <name>A0A2X0MNV7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C022g09438 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C022g09438</name>
        <name evidence="2" type="ORF">BQ5605_C022G09438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MNV7"/>
    <dbReference type="STRING" id="796604.A0A2X0MNV7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05271">
        <property type="entry name" value="NDUFA9_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF11">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="58"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ22161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="375" mass="41463" checksum="D76D58CFC9F8CBD4" modified="2018-09-12" version="1">MASRVFSSAAQLARSTPASTRSVSSVPSSVIVPATQTKKVFTPKGPGGRHSSTGHVATVFGATGFLGRYLVSKLAKAGTQVVVPYRDQDEARHLKVCGDLGQVEWDLKNDTQIEECLRHSDTVYNLVGRDYTTKNFSFDDVHVSGARRLARIAHISGVSRFIHLSHLNAAPDSASQFYRTKFHGEQAVKEAFPEATIVRPGWMYGHEDRLLNTIAVSPSVFRVNHGETRIAPVHVMDVAQALSIMLTAPSTASSTFAFTGPQTYTFERLLHLVEALTLQKLSGPNFPKPILALAARLWDLVWWPTLSPDEVTRRFIDDVQIEEGLKGFKDLGIEPDVLEDVAIVYLRRYRSSSYFDLPVASGGIKLRSQKYHVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MP62</accession>
    <name>A0A2X0MP62_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C022g09548 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C022g09548</name>
        <name evidence="1" type="ORF">BQ5605_C022G09548</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MP62"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ22827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="259" mass="28699" checksum="44E27248F334C833" modified="2018-09-12" version="1">MTTAQPILVLRHIYEPAVQLPRIALKPLKPNISIRDDLGPQTAVCTHCKARHWEGERSKSIGHFSTCCSQGKKLKHFTKPRGTPVFRLFGRLGHRLGSLIAAVNQRPVFAQTWLIDLAEATDTRLGPDGADTRAGWDMAKEWILQLCIPLGRRRRTHNHPPSSTEMARLICDSDTNTGDRGPQYLILQVHGDRCPDGRPKYTKSSARSIRSRCLSGTHYSSPRGQMASTPTFFFASSTKLGLPSPETESRAAMVSDCAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPT7</accession>
    <name>A0A2X0MPT7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C046g12267 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C046g12267</name>
        <name evidence="3" type="ORF">BQ5605_C046G12267</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000112">
        <property type="protein sequence ID" value="SGZ30904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MPT7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="486"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ30904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1279" mass="143722" checksum="2995373A255DE6D3" modified="2018-09-12" version="1">MMNVFYKKKKKIPHVLTLIPDGSPLAGRLLSSTPVVFAEAIQFDGRILRSVFRLEELDIEIINMYAPVKGEERRDFFGLLHFNAPRPKTLRILAGDLNDCPDVSVDRVSITDRAWTPVSHWQTLLSKIAFKALDTVRHVHSCTPAFTRPHYRGRGEERKICSWSRIDYILVQCSWANRLLSASTLFDAPCSDHRPVVATFALPTSNADAEPPLSLPSTSDFISRLNPTVFDDQDFVASIPGVVDEVYRRLEGTAPLGDVYDAALRAVAVAGHARYRSTRADMRRLRAESQSVMEALEARGEHMNEAERDAYAFAKSRLDQLAVKEAQWLRIRAHVPSVDSREGQSASIRTRLNRRSRQTSIVSLEDVDGTETVDMQEALGIASRHAQSLFTPDPARGDPTNPRRSLLDPIRAAKCYDDDRSDPTFGRRLPRQARVALDEPFTLLEVEAALKKTDSGRSPGPSGIPYELFKALPTYFAPKLLDLFNSIWEGGKMTASLAEGLVRLLPKNKPGANLKSLGAYRPITLRETTYKVLSKVLVARLNGVLGELLPPAQHGFMPSRRSADAGSHLTLLLEKLRSLGTDVFPEGALLSLDQQSAYDRVDHAWIFDVFEAFGFGERFISLLRALYDPETLGVRYLINGFPTELVRLLCGLGQGDPLSCPVWNITFQPFLDALVRRGIALDLQKVWPGGPRAQLTHLAFADDAVVVVESPAALSKLETLSQTWYEATNGKTNTDKTLVLPLGPNWLRDETAQALPTVQEGESFKWCGYAFFRHGDSKLFWTHVLDRIKAKTRAAGDRTLSPSGKVFYANAHIISTVLHVLSFDIPPQWFIKAAETALTDFVWGGAGRNTVARDFVFQAREDGGLGLISIGDIVHSVALRFWDAVAGSNEAIWAPLARESWRSLVAATRDFSPWGFFSSTARVEKLYRDSTRWGAVVAAARVTVPTIKSELLTLPELLSLPPRLPSLYAEGAKHAYDDADAVAKFAQIADLYWRDEGKGWALVGHRRGFWQHSKEPALQHEHVWSRVGQLLKAKALLPKTALRPARIPLKEAPRPRCFNFFGLTRPFTIRKLRRLVNVVRFPGREDRVKRFRDGTSQSDRKRFWRWLHDRFASAVEQNTHWRLMYDVTPTRKRQHTQGHASSPTCLFCGNDAAAIETVSHYFFECAYSTSFWGGVLRILFDKLGIEDTDVDPSTFTPEQLTMGLPLLRGRGRTTSRWMWVRLACAIGFQRLHLLRWRVHQRFELDKVVAPPSLPSALRAFERDFLSRAGFVPGARDWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQB4</accession>
    <name>A0A2X0MQB4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C016g08179 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C016g08179</name>
        <name evidence="7" type="ORF">BQ5605_C016G08179</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY20978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQB4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF33">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY20978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="127" mass="14065" checksum="9208CCF83CEFA7D7" modified="2018-09-12" version="1">MATATGITYLARYIGQVVGVAVSSSLLQAVLNVTLHRRITGPDAEKYIDQIRHVSTSIPSLPPSIQPLARSSYLDALRSVFILNAIVAGISFLSCLPLKEFPLPDTFKEEEERRRENENARLGRVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MS34</accession>
    <name>A0A2X0MS34_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C051g12554 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">BQ5605_C085g13009 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C051g12554</name>
        <name evidence="2" type="synonym">BQ5605_C085g13009</name>
        <name evidence="3" type="ORF">BQ5605_C051G12554</name>
        <name evidence="2" type="ORF">BQ5605_C085G13009</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000040">
        <property type="protein sequence ID" value="SGY28745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000096">
        <property type="protein sequence ID" value="SGZ29604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MS34"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY28745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ29604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="152" mass="16710" checksum="2A7B3FE2BCC927CF" modified="2018-09-12" version="1">MRSRLQKEDKSNFYTEALFIVAGKPRESDRNSWKQVEAKGSDRDCKNLTPHAGINGGVPDAIWHSIPQDLSRLHTFGCRAWATIPQHDRTKLKPKGIPLIFVDQVPCRPATCLRAQTALCCPYNRAAPRPGASSGTSRSRCTSDSGVAHVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MSK7</accession>
    <name>A0A2X0MSK7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C048g12379 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C048g12379</name>
        <name evidence="3" type="ORF">BQ5605_C048G12379</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000110">
        <property type="protein sequence ID" value="SGZ30485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MSK7"/>
    <dbReference type="STRING" id="796604.A0A2X0MSK7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022771">
        <property type="entry name" value="WAPL_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07814">
        <property type="entry name" value="WAPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Wings apart-like protein C-terminal" evidence="2">
        <location>
            <begin position="611"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1013"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1013"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1023"/>
            <end position="1036"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ30485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1206" mass="128619" checksum="A87C117057E10B2C" modified="2018-09-12" version="1">MAIASTSSPLPRSDGGEKSRMNNTRTYGRRGVAAAASASALALASATKTTTTTTTTTTAAIRDSTSATFSYTGSHRKASMLHLDEESSSSSSSSSGSDTELDESIEKQLGLGQRSSSHQTLSRVDKRKGKRKESPTEEPPTSSIEVKTLASKRSTSTLRVKQPQRTASRSSADRDLVSAPRSASRALPSSVLPSVSTSSASSTWTPKRALQLKSKEVLEIDDDGDDDDVEEPPSPPPRKKRPLASKTTTPPVPVLVSVSTTSKPTLAEPTSEPAANSHVPSSQTDTPHVSPTKKRKASEPEQKGARPSSKPRPSTPPPPAPSRTSPAARLSKPSTPNTSRSIAASKLAATSTLAAPIDTPVASPLRSPAKDLSGIFDSFDSVNTSATDGARSTTLNELSPKRPGKIPLKETMSTGSIVAGMAPRRRGFSPELMRQGSLTPTSSRTINALSPRPLGPSFSQPNLSPTRPASRQPSPSRQTSPSTSHIASTTLQNNVVPCLIESGAIAPRASGAGVRKTYGAGGGRSFRRSKDEDELMGINSSGKEEQEDLSHDSVGDIHPERALGFSKTTTGMKTTTTAATLRRSYSSMRIEYGVEEEETILLESQQASSLSSITQLIAKGESTKFTDEVAYLLEGMSEKEASLALRRSSAIELVRKVVEEREFGKRVKSLGLEEAVYKALRRCAIQGGKGVGVGERTGDRCLEVCLAVFLGRIAREQRGFEPLMRVTRGDVGGEEIRNRRGAEGMNEGDVLGMVRGWLEVGWSCEEIGAPAKGVGKAELRSLTILRNLIISNELIGSTSSSGSYPTTLESLAIHLLSTIASFEPRAIFRPQLLVCTSGALKALVGTLMRGSEALERRLGKYEKGLELLPLPEDAGTTTTPSGRSNPHLPLLALQIGVMETCLSVCSEQALEPLTDHSNSIVSSLSTLILVSELVIFGGAAGPPRSSTTNIKTDPDVAQPELRAAMACLSGALKLVLQLTIADARWSAEFVAVHRGRIVGSLVRVLQSAKKRMGEGEGIRRGEDEGEGEADGAEGTEEAARSTFDLDLLCLALGTLTNLVESVDRVKTILRETLLSPTCQERRRCTFVCYCEGREPALAVLARLYLQTPATTNEVSSGINTSFLTGYSGLLLGLTMVDSEPNEALVEEALEGHPQARKELQAAMDDFASLHEAVEEGREGEGDVGYRDREKSQVAGRIREMLRRMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MTD3</accession>
    <name>A0A2X0MTD3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C006g04188 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C006g04188</name>
        <name evidence="3" type="ORF">BQ5605_C006G04188</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY56881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1368"/>
            <end position="1635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="734"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1947"/>
            <end position="1973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="564"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="663"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="741"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY56881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2124" mass="234286" checksum="6D7DD796E901AA87" modified="2018-09-12" version="1">MEDVLPKLWHRRYNHPTLEIQHPIHTREPWRRVEIALDLLAKGIGVIALHKAAPQLCVDVHLRNRLYGIRLPLRERVPAHRVCHGVLASWNRFVVRKDMEVDTHQVDSPLTQGVHNRQKLLFMGRVVDLRIDVLTRPIHHRVCLAPILPLKQHGAYPNVTCVRHNPEGISGIRVVDRLETCQRGDDGLYGVEVRPPTASRATGRLQEVMPDPPGPPPHPPNAPWAGDVLRDESLNTETRETVTGGTVNPPAWSAQASQARLDHEKSMQKAFKALGIVPSSKSTRRLMVLLYDPSSPPSQAPALARAAQRAVRNDAMPASNVIRVIMDGTGSPRGPVQIALRKHFGLAKTPFMFARPEGAELDPEVEKLFSKCVKLNPIVTKATKRFPIARHMYELVFESDQACLEAAAAGPFPYHGKEMVTELPSVSPLNHIVQVRFTLPSSSSAIPASVLRKSLENALTSSFGHAGCTQGYTLMQLQRGLAVDPNGDPMAMTEDGFHCAYLRLHADLFQGSTETQKAALNAALPQEIEILGAKYGLRHEFETRYCAVCDRAGHQWGACRKPVSTPATAAPVPGASTSTSTSTTGFRVAGKNGKHGGPAALNSRASGTNMIQLGPRANPAGAATGYKDDANDGDDDDDDDDGESVASTEPEGGDTGKETLTRATTGPTKETQTTTAAPVSTPTSPSPSTSAPASPLSGGTSESSATSTTSIASTSPRRLRSSSAPGNRRVTRAGSAMIHGASGGDDSGGNSSGGYRSESLTVLTFNVRSIKNAVNQVKIIRYLKTLRPAPAAILLQEHHLSYNALREGFESAWPGACIRFAPHVLTLIPDGSPLVGRLLSSTPVVFAEAPQFDGRILRSVFRLEELDIEIINMYAPVKGEERRDFYGLLHFTAPGPKTLRILAGDLNDCPDVSVDRVAITDRAWTPVSHWQTLLSKIAFNPLDTIRQLHPITPAFTRPHYLGRGDKREICSWSRIDYILVQRSWANRLLSASTLFDAPCSDHRPVVATFALPTSNAADAEPPPALPTTSEFISRLNPTVFNDQDFVDSIPGVVDEVYRRLEGTAPLGDVYDAALRAVAAAGHARYRSTRADMRRLRAENQSVMEALEARGEHMNEAERDAYALAKSQLDQLAVKEAQWLRIRAHVPRMGEIDIECVLKKKERVNETRALDSIRVQATSESNQYATPPSASIRRRATRAPTSQCHKSLWTADPLLISHNTVDSREGQSTSIRTRLNRRSRQTSIVSLEDVDGTETVDMQEALGIASRHAQSLFTPDPARGDPTNARRSLLDPIRAAKCYDDDRSDPTFGRRLPLQARVALDEPFNLSEVEAALKKTDSGRSPGPSGIPYELFKALPTYFAPKLLDLFNSIWEGGKMTASLAEGLVRLLPKNKPGANLKSLGAYRPITLRETTYKVLSKVLVARLNGVLGELLPPAQHGFMPSRRSADAGSHLTLLLEKLRSLGTDVFPEGALLSLDQQSAYDRVDHAWIFDVFEAFGFGERFISLLRALYDPETLGVRYLINGFPTELVRLLCGLGQGDPLSCPVWNITFQPFLDALVRRGIALDLQKVWPGGRSPAALSKLETLSQTWYEATNGKTNTDKTLVLPLGPNWLRDETAQALPTVQEGESFKWCGYAFFRHGDSKLFWTHVLDRIKAKARAARDRTLSPSGRVFYANAHITSTVLHVLSFDIPPQWFIQAAETALTDFVWGGPRRNTVAREFVFQTREDGGLGLISIGDIVHSVALRFWDAVAGSDEAIWAPLARESWRSLVATTRDFSPWGFFSSTARVEKLYRDSTRWGAVVAAARVTLPTIKSELLTLPELLSLPPRLPSLYAEGAKHAYDDADAVAKFAQIADLYWRDEGKGWALVGHRRGFWQHSKEPALRHEHVWARVGQKLKAKALLPKTAVRPARISLKEDPHPRCFNFFGLTRPFTIRKLRRLVNTVRFPGKDGQDRALPGGQPQEPRVKRFPEGTSQSGRQRFWSWLHDRFASAAEQDTHWRLMYDVTPTRKKQHVQGHASSPSCLFCGNDAAVIETVSHYFFGCAYSASYWSGVLRILFDKLGIEDTDVDPSTFTQEQLTMGLPLLRGRGRTTSKWMWVRLACAIGFKRDFLSRAGFVPGARNWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MTE9</accession>
    <name>A0A2X0MTE9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C047g12332 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C047g12332</name>
        <name evidence="1" type="ORF">BQ5605_C047G12332</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000113">
        <property type="protein sequence ID" value="SGZ31198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MTE9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ31198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="93" mass="10351" checksum="C84F7B007B8386D6" modified="2018-09-12" version="1">MFKNLDNYPAMEPNGSLFIELIVNDLVKSASCATWAYSATIVTRTARSLQGLHCTVDVSTSLCRCVYYLLIRLAATSSFKSSTWLCPRVPRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MVG3</accession>
    <name>A0A2X0MVG3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C003g02159 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C003g02159</name>
        <name evidence="5" type="ORF">BQ5605_C003G02159</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MVG3"/>
    <dbReference type="STRING" id="796604.A0A2X0MVG3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF236">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY39161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="332" mass="35738" checksum="61CAE6984C22160C" modified="2018-09-12" version="1">MLSSLLEKIAPTSTLSTTFFPPAALFSAEDMPDLSGKVIIVTGGNAGIGYETVKALLKKNAKVYLAARSQDKAEKAIASLRQDTGREAIFLKLNLGDLASIKPSAEEFLSKEKKLDVLFNNAGVMTPPTGQLTESGYDLQWGTNVLGPYYFTKLLIPALKASKSASGTPSRVINTSSLAHAYAPTSAPNKVWDVDSFVGGEKRDALIKKRGEYGARSALYGQSKAGNIAHANYLGREHAGDIVACSLHPGMINSELQRHLPGFVASIVKWMSYPLTMGALTQLNTGTILTPEEINGKYYQPWGRVGHPTTQSNDPARADELHQLCEAELAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MVH2</accession>
    <name>A0A2X0MVH2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g02169 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g02169</name>
        <name evidence="2" type="ORF">BQ5605_C003G02169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MVH2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY39209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="236" mass="25925" checksum="02E6058BDA28C186" modified="2018-09-12" version="1">MTVKHGHDCLGHALEVVPDALLSRETNLSSALVSLVGKIDGKSLPQSPFAALAIIDGATAFARQRQAATDRAKHHEPKRGRLFLNSIIRHLEEIISATARRIQVVVVFDHPILRPELKRNTVLNRQDRQQTQQPSDKSTPVTHPVPFITNDTVAACVNGQSSKEWEVDVCNGDEPTRVATFVRWSEQGLLVVAAHEADPLVSASTKFGQICDRLFHASRRRPSPLSRGAIGQGPKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MVY8</accession>
    <name>A0A2X0MVY8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">xanthine dehydrogenase</fullName>
            <ecNumber evidence="4">1.17.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">BQ5605_C004g02802</name>
        <name evidence="24" type="ORF">BQ5605_C004G02802</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>hypoxanthine + NAD(+) + H2O = xanthine + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24670"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>xanthine + NAD(+) + H2O = urate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
        <text evidence="20">Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="20">Binds 2 [2Fe-2S] clusters.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the xanthine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.4" evidence="4"/>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY67730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MVY8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004854">
        <property type="term" value="F:xanthine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000015">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000003">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.50:FF:000001">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000002">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000004">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase/oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000004">
        <property type="entry name" value="Xanthine dehydrogenase/oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.120">
        <property type="entry name" value="[2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.50">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.365.10">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.50">
        <property type="entry name" value="CO dehydrogenase flavoprotein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046867">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444:SF3">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="MoCoBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20256">
        <property type="entry name" value="MoCoBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000127">
        <property type="entry name" value="Xanthine_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="CO dehydrogenase flavoprotein C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="CO dehydrogenase ISP C-domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="CO dehydrogenase molybdoprotein N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <begin position="17"/>
            <end position="106"/>
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            <begin position="339"/>
            <end position="529"/>
        </location>
    </feature>
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        <location>
            <begin position="240"/>
            <end position="282"/>
        </location>
    </feature>
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            <position position="1392"/>
        </location>
    </feature>
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            <position position="58"/>
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        <ligand>
            <name>[2Fe-2S] cluster</name>
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            <label>1</label>
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    <sequence length="1460" mass="157588" checksum="FDF0CDC681FFB0DA" modified="2018-09-12" version="1">MPDGSFVEPFETQGWSSQLVFYLNGTSIALDGSSIDPDTSLLSFIRSQPGLTGTKLGCGEGGCGACTVVVQSKHPVQGHIQHLAVNACLAPLISVEGKHVITVEGPSDNPHPLQERMWKLSGSQCGFCTPGIVMSVYALLREAAYRGQLTVKDVELEGVLDGNLCRCTGYAPILVAVKSFVGGYLTKVNGNGAEASSGAKVDDSLVVPFNFDASGLDNEDATKKAKAGACCGSNGCSKEASTDVSMPVPSGKDTSEPPIDATAGAMGRTAPTGSSTDIKPTKPKGCGRADCCQLDGGKGPASTAPTHSFPRFEFKPYRPGVELIFPPGLQSHKLAPIKFGSKGRMWLRPTTLDQLLSLKAQYPDAKVVGGSSEIAIEVGILGRKYPVCLFVSDIPELYAIELPDLKSNKPTFTFGANTPLSEIEQVCKDLTKSLPKNQAGPFKAIKDQLRCFAGRQVRNTASVAGNIATASPISDLNPIWLATGATLIARNESQGEFELPLASFFTGYRKTALPADAIIVRIIVPVNTSSETEVVRAYKQAKRRDDDISIVCACMAMRVDADGTIKSAKLAYGGMAPFTIAATETQDYLVGKSITSDTLEGALDVLAKEFDLAFDVPGGMAAYRRTLTLSFFFKFFVTVSIESGRPLDVAKELSSTEEITESIHRSISSSTRDNSDPYALEVVGKQEPHMSGLKHVTGEAIYCDDIPSIANEAYVGLVLSQRAHAKIVSVDASDALEQDGVVGFVDHNDLPNERANWWGSAAIDETFFATDEVISHGQIIGAVVAKTKLIAAKAARLLKIEYEDLPVILTIEEAIAAGSFHPQYERRISRGDEISKAMSESECTLKGATRMGGQEHFYLETMASLVVPKGEGGEVEVYSSTQALNDTQRWVAQIMGVPRNRVVAKVKRLGGGFGGKETRSAMLTAVCALAAKKTKRPVRAMLDRDVDIRTTGQRHPCLGEWKVGFTKEGKLTALDVQFYANAGYSLDISGGVCDRALAHLENSYWIPHVDFRARCCKTNTVSNTAYRGFGGPQGMIVAEHYLEAIAEHLNLDIDHVRKINLYKEAQKTPYHQKVLDWHVPRLLEDCRKESDYDQRKQAVDKFNKEHKYRKRGIALVPTKFGLAFGVKAMNQGAALVHVRPDHPQYMDGSVLVAHGGTEMGQGLYTKCCQVAAQELQVPLSSVFTSETATNTVPNAVPTAVLDFIGSAGSDLQAHAVYNACAELNKRLEPYRQKLGPDASFAALAGAAWGDRISLSATGHHAMPDLGYVWNEQKETGNLFHYFTQGVAAAEVELDTLTGDHTVLRVDLKMDVGKSLNPAIDYGQIEGAFVQGQGWCTIEESLWLKNGAIQTVGPGAYKIPGFADIPQVFNVALLKDAEWPNLGSIKASKGIGEPPFFLGCSVFLALRQAVKSARMDQGIQESAEFRLPLTSERLRLACGDRLVQKAKVEQKEGQKGFFVYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N170</accession>
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            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
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        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <dbReference type="EMBL" id="FQNC01000051">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <location>
            <begin position="82"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
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    <sequence length="196" mass="22004" checksum="F10A264C8FC79AE8" modified="2018-09-12" version="1">MLELSRASIYLYDLAPRSLPLASTCFHEFLSLSLGFPATIDRASYSYKNNYINPASRPHFSIPHGTQRPFLEFGFYGCTPKSRPNDSTHPVTSREPTPHHDPRHQRLDPEPNRDITQRYQDAMACVVKGKASAADHDDVRPRLTGNQGCTGADSACNRPDLIARVFEAKSGNKRHAGCFGDECKMNRFCFFAVLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N4N3</accession>
    <name>A0A2X0N4N3_9BASI</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C005g03426</name>
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    </gene>
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        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
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            <taxon>Microbotryomycetes</taxon>
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            <taxon>Microbotryaceae</taxon>
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        </lineage>
    </organism>
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                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY75433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:DNA replication origin binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20704">
        <property type="entry name" value="Orc3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020795">
        <property type="entry name" value="ORC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045667">
        <property type="entry name" value="ORC3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040855">
        <property type="entry name" value="ORC_WH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07034">
        <property type="entry name" value="ORC3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18137">
        <property type="entry name" value="WHD_ORC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 3 N-terminal" evidence="7">
        <location>
            <begin position="114"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 3 winged helix C-terminal" evidence="8">
        <location>
            <begin position="682"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="33"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="731"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="738"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY75433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="795" mass="87534" checksum="0ECDB5083076E674" modified="2018-09-12" version="1">MHSSRLDGAWAVPAASTSRSVVTLPYRAPQAQLTEGNSHGHNNRGQNNALSADDTARQGRSARGRDVIDTTSAKARLQQQQQQAFDFFDSSRKYHEPGQDWPCVFAYIVAPGADQSWIQPYTRAWSATAQRIQSTLSTVHHSSLDEITAFANHCAGQGSRPSLAESLTAGSLLAVGLLIGANPGASALLFSSLTRHLVLPHHDQTTANSAPPSLVSRISSRDCVSLQSALRSVISGFMGRPKFDDSDEEDAEGEAVVSSGLKSATLPADDVRNLCVWYAHKYRNTQQRMRPGLVVMIEDLEGIDATVMTSLFEVLHSCASKVPLTFLIGVATSSDALYHAIPRTCANLLDVTEFFVDLGLSAFNGLMTSISLAWDPPVVLGPQIQDTLLHVFDESHHSIDATISAMQLAYAQQFRTQPAAVLGDETDFDQNDFHDVVEMLLALPSVAQAGPAFIAKIEESADSAWAAIEGARIAKKGWHMRRRLAWELVEAVLEVWAPRRTRSVQERWSLLERGTLLEEAAADWEKLILLSSAEKIQRWIEISLGRLEAISADNTETGQQLFNSKYRSDELVQQLYSSGDGRQNFVNSNVAGMEAVHGLTASASIDIEFSSFTKAMATLFSDTLKNACESFKSIPLHEIWYVDDPGPLKRTRPAYLSCVHRCLSGPETRAAGPPKRASRRDVDQSAIDLSNDLATAYKLYQETGRTINLADWFTAFDATARAEETTTIRRKRRRVGQEDLDGDSSDHEAEEEDEEASDPRRRTQARFLRVVGDLAHIGFLNPTSRKSEHVLKNIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N5H9</accession>
    <name>A0A2X0N5H9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C020g09071 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C020g09071</name>
        <name evidence="9" type="ORF">BQ5605_C020G09071</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000082">
        <property type="protein sequence ID" value="SGZ16830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N5H9"/>
    <dbReference type="STRING" id="796604.A0A2X0N5H9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16536">
        <property type="entry name" value="RING-HC_RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039739">
        <property type="entry name" value="MAG2/RNF10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983">
        <property type="entry name" value="RING FINGER 10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="165"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="568"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="632"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="689"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="731"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="570"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="581"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="689"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="733"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="748"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGZ16830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="800" mass="85993" checksum="92A076C51D205852" modified="2018-09-12" version="1">MDPVQGGCTPSQLALSMGTSSAVVDSKSASSSIASGSTATGLPSSQQNGTARRKGRQVQDVNHLQLLGFTLPPRSTPPLASAPRRSNKRDPAYHGSFDRARYIHTFRFVVKPDKDYTANLADHDVRLDWADVLQVILPTASSALSTVLSSIATVLDQQPGSAPTCPICLSEPTAPRMVSWNRTKCGHVFCFPCILHYLALADGQKWRKCPVCWDSVYATDLKVVKWHDAVTSAQYDSSPTADLAALSIEDLSHSLLHDHSRNATAESLGGSSGGEPLKMRLIRRPKISTLALPRSDTWPSEAVPPLRAPWNFSPDAFVFAKFMLGSPEYLKEELDQNMRDLEQEVSILRQCGRQGGTDEELGIVFVRAATVKVSEQLQKVGVLKTTSVMTARKKALKEIQEIRDRPGKLPLGPSLPLFSETSSSEVEDAPSELLGIRSLNGGRILSGDAPVFQPGGPGARARPQRKNVNPAPALDADSTYYFYQAASGQNIYLHPLDIKILKSHFGTYQGMPDVISVKVEGADEGSMNDDLRRRCRWLAHLPTSCDVVFIEADLTSVVPGSSLEPFSHALKQRRTKRRDKARREDKAKLKSEQKEVEARPVYMATYGSVGTGHNSWSNVPMTTASTQQMMASTTAFPPPSSGSNPGSSGGDAHGFPSSVSPTRPAPISTWGYQAPSTAANTQSFAAPRSFASALHSSSRPSPSRPSQGHDLDDWDDAEFDERWHDFEDRLHGASSNSFSSLNLKRGASRGGGSASGSNAGGGAAGKDGSATPKQSFGGKKKGRKAALTLNLSGAAMRGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N7C7</accession>
    <name>A0A2X0N7C7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C009g05598 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C009g05598</name>
        <name evidence="2" type="ORF">BQ5605_C009G05598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY82829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N7C7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="872"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1044"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="872"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1066"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1114"/>
            <end position="1123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY82829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1123" mass="125130" checksum="5AE9A108EACA3CAB" modified="2018-09-12" version="1">MSAPDRSSCYDSDAASENAADTCTRPTPQGLPHPTTTSTTSPLLPLVHSLVISRLRDRLVQSNLQFDPEEISADGLSFLFEMVGGDLGALESVAFASYERATTRHYLLSDQELARLLDLVESTSEDLNPGADEHVTYVRSWALQIEELALLVEAWIEAGIAVPESWSWLVDAFAQEDPNKVIHVRYVGSTRGQTAYNRFIEDRRQRKTGIVGEFLGTLLEVAPRAYEHGKTFEIRNARLPSSASSAFRDLREQVIIAFFGRHNLLNVQAGGIYASYAPDPSDVEFLKNPTSRFFQTFAQWSKPVPQAMIEQLKHWKEYVADLIASNPQSTRSAVLPLPAKTLDTIFGQAIPSQIGGLVPMVHVGLDITFEAYLDGSPFWSGHSRAGHVTRIFAQRHAAYELGRDDFELDVSAMPFVDVFPWPCKADLDLGLAQLTMYLGVVLPILVVASSHLSFSCAMANWLHPLGIRTDAEFFSHVGKVKRRYLLDSDYLEDETQLEPPGDREVLVIGHVHPGFDKYGAQPQELRRVFDICHAITCFVAGVVVEKSHLLAQGRPDGRADRTAVINEVMKTLDSSSRFSDLEQKRDQWVAEYQLWEVEHRAQYRPRMGTAVASRVRKAGARRRVSNVELAWGDVGSAERRRQLVRVWKLQNPEYFLCLERPVTWEKWEQWGGAVAKGNSYFATALVQAGRQRLVAQGQHPLRSVLLAFTPDDATDESWMADSVAVQRALSAWSRKALAHLPTDHWSSKKQRARTLKRGIIFLDRLEGEVAEFNFSNRKCEILLRRHDADVDDDFTFRLRISPSFAPRAQGERRILHFLPGGVGLEDENGNFLQRDGFTPEEGIFRARDAVLGHRGDVFARIFAAERAALAPAAPARTATATSTSTNTLPATTTATQLLMPPTGEPPVTSTTRKQKRADAREQVISPGDGVWLLKQWVDWRCGFEKPITFNTLDPSDARLSADLRESSIATSFVRFLDQEPYASHPWKQRWLDWCNDMKLKGKNIVANLELFRLIQCRTGRVNFRAGGMIDYRIITIFPQQVGASARPAAPPTSPSLLVSGPRSFVPATTSRPSRTTLAPASRSDSAVAGPGPSTEASRRARVAGNVAPTKRSRSPSPFEESSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NAL9</accession>
    <name>A0A2X0NAL9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C003g01826 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">BQ5605_C052g12566 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">BQ5605_C099g13115 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">BQ5605_C099g13119 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">BQ5605_C099g13123 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">BQ5605_C122g13311 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C052g12566</name>
        <name evidence="6" type="synonym">BQ5605_C003g01826</name>
        <name evidence="2" type="synonym">BQ5605_C099g13115</name>
        <name evidence="3" type="synonym">BQ5605_C099g13119</name>
        <name evidence="4" type="synonym">BQ5605_C099g13123</name>
        <name evidence="5" type="synonym">BQ5605_C122g13311</name>
        <name evidence="6" type="ORF">BQ5605_C003G01826</name>
        <name evidence="7" type="ORF">BQ5605_C052G12566</name>
        <name evidence="2" type="ORF">BQ5605_C099G13115</name>
        <name evidence="3" type="ORF">BQ5605_C099G13119</name>
        <name evidence="4" type="ORF">BQ5605_C099G13123</name>
        <name evidence="5" type="ORF">BQ5605_C122G13311</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000001">
        <property type="protein sequence ID" value="SGY11465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000001">
        <property type="protein sequence ID" value="SGY11476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000001">
        <property type="protein sequence ID" value="SGY11486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000030">
        <property type="protein sequence ID" value="SGY27902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY37489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000099">
        <property type="protein sequence ID" value="SGZ29926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NAL9"/>
    <dbReference type="STRING" id="796604.A0A2X0NAL9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase/retrotransposon-derived protein RNase H-like" evidence="1">
        <location>
            <begin position="229"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY11465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY11476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY11486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY27902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY37489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGZ29926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="300" mass="33446" checksum="E38F4575C326422C" modified="2018-09-12" version="1">MRSSEVRSAVERHKVAAVERYAVSDQDEIVNAVAAANFCTKIDLQGTSQQIRIKDEDVKNTAFSTPNGILYLLVAQQGDRNSTATLHRLVSFAFVRLYNRKIKHYADDLWPISNTKKIRLGESSMQPEKAAGIRATPAPKYKKDLQRFLGAMGYNHRSTPHLAELAAPLDALTGVNSPWRWSRACSDAFETIKAAFDDSAKLTCIRSDELAPDGTFPVPLDTPPAEGEKVLENESKGKYLFLQIGASVTGVGYVLSIGTNWWTAIPTGYHSRKFSPSQFNYNTQDQELQGMYEGFKRFET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NDC6</accession>
    <name>A0A2X0NDC6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C022g09435 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C022g09435</name>
        <name evidence="4" type="ORF">BQ5605_C022G09435</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NDC6"/>
    <dbReference type="STRING" id="796604.A0A2X0NDC6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051646">
        <property type="entry name" value="NatB_acetyltransferase_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ22141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="213" mass="23999" checksum="7283EAA79DBA1B90" modified="2018-09-12" version="1">MSLLRPFSACDQFAFNAINLDLWTETYGVGYYGHYLSTWPDLFTVVESAGGKGRRDASRGIGGEGGGLMGYVMGKMEGRGEEWHGHVSAITVSPAHRRLGLASMMMELLERVSDQQHAFLYGHYTDLQRGLVEDVDLFVRVSNNLAIGLYEALGYIVYRRVKKYYGGGPGQADEDGFDMRKPMSRDRQHKSIKLPNGILDGRDYEVRPEDVYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NE77</accession>
    <name>A0A2X0NE77_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C024g09769 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C024g09769</name>
        <name evidence="8" type="ORF">BQ5605_C024G09769</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ25779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NE77"/>
    <dbReference type="STRING" id="796604.A0A2X0NE77"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012952">
        <property type="entry name" value="BING4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040315">
        <property type="entry name" value="WDR46/Utp7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085">
        <property type="entry name" value="WD-REPEAT PROTEIN BING4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08149">
        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01033">
        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="282"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="BING4 C-terminal" evidence="7">
        <location>
            <begin position="347"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGZ25779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="422" mass="47344" checksum="4594599FD7709ADE" modified="2018-09-12" version="1">MQGTPHQVGKGKGKQREKETPTSLLSNSRQLPAQDPYVPATQSLKKYVYAHPTMLDKNHLSKGAGKTNKRLGHHLHHLSTSAKVSSIKAHEHDDLLLDRSIQGLIEVENELERTWKVTQDEIVEGSAIGAQGKAFALKLDEFGRMRSTTRAMGDISPSQGGRGMSAPSTGNQGVSSPVAQKKYVYIYDKSGLEVHQLRNHIEVNQMEFLPYHFLLATIGHWAIGFLKYQDTSTGQLVVEHRTKLGACRTMAQNSHNAFIHLGHQNGSVTLWSPSVSRPQVQVQAHRGPVSSIALDPSTLGYRMVTCRRRRFVKLWDTRKWAVLNEYQFKRRRRSAKTGSEPEDAASPYLTHTFPGVAVNETRFCPFEDVLGVADPYEGKRRRREREVNALLDKVPFDMITLDTEMVGKLDRDVRDKAESSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NFH4</accession>
    <name>A0A2X0NFH4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C026g10161 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C026g10161</name>
        <name evidence="1" type="ORF">BQ5605_C026G10161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ27678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NFH4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ27678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="396" mass="43987" checksum="36F1FE79A63E4BC2" modified="2018-09-12" version="1">MSDLPVEIIRLVLALSDETNYDDEYGFSQAKGFRPDHYLTAGGRAGVALVARGAPGFNPSYIDMPIHEPTTSVSDVWRLLPFEKIVSHCTALKSVTLNVYAMPSRKSWRVWHRALDRHAAVASPIKSLSCSLPFTSEALKLFACLGSELQELVVRGWEDEATTSAPDVEQELYHILRMNALLPSARTGVVTFGLRKISFVAEGFVSAAFIQSLPFIAPQLEELHIAEEVEILEADDNNRGSDLTFRDLIASLPPSMKSFKIYASHDAHLNLGTFEGLGAHIPGLMHLGGRSHYFNHDILSALAEYGKVSSLCIHSTRRGDEVSARYEDEDDKRAVYRDETLDSRAAVQEMGAVARDMMVHGMSWRQEDDHEKSGVIDRMMRLARGRAQRRDAAESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NG72</accession>
    <name>A0A2X0NG72_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C027g10442 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C027g10442</name>
        <name evidence="2" type="ORF">BQ5605_C027G10442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NG72"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ28764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="227" mass="24828" checksum="BD70C7EC67A60E31" modified="2018-09-12" version="1">MTIRTRNQKYCIPFDRLTLFSVFRCLAAPLPYPCPALPVPHRHHVEAKPARSGHDLLVPARIRTLDFALDPTDVDHWTASFTVGDADDDPDPEVYVCDSRRKSSFVKQGTLESTLPRDRELWKPNAQDSGAFLNTLLRLPRDANPLLVPVPAPREARQREGDSSEHAQGGGGGGLASTSSADSASTCTSTLPAPSTGTLGVPKRLCPGTRRRRAPVPTARRDRSLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NM97</accession>
    <name>A0A2X0NM97_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C010g05971 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C010g05971</name>
        <name evidence="2" type="ORF">BQ5605_C010G05971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NM97"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY13772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="82" mass="8951" checksum="100B1442C97E2DFC" modified="2018-09-12" version="1">MQRQSLAHFKSLGLTIGRGNRLGTKTADYLRTARGKCFDTTWSYCPIRCAIRAPLASGGLRRPAAVEPEQPRPPILEQGGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NS23</accession>
    <name>A0A2X0NS23_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C011g06498 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C011g06498</name>
        <name evidence="3" type="ORF">BQ5605_C011G06498</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NS23"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029164">
        <property type="entry name" value="PIG-Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36485">
        <property type="entry name" value="OS01G0939000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36485:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15159">
        <property type="entry name" value="PIG-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY12408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="183" mass="20700" checksum="4AE178040DA2065B" modified="2018-09-12" version="1">MATKNKSRSRVASITNNASSIQLPPLPSSLSAPGPASTPRIEHEPPPFSLEQLASLLDQEQDDRHLRPHIMRSSSSNSGLRYDYAESSGEDDEDDEDDELTTVEVVNYEMMYWGYGLVITCTTCFILGTWSMFIAPFVGPYNNKILDAMANDTHYKYLFVFLVPVTLYTVIINWWGLKIFRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NSR3</accession>
    <name>A0A2X0NSR3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BQ5605_C010g05865 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C010g05865</name>
        <name evidence="12" type="ORF">BQ5605_C010G05865</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NSR3"/>
    <dbReference type="STRING" id="796604.A0A2X0NSR3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AWS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050777">
        <property type="entry name" value="SET2_Histone-Lys_MeTrsfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22884">
        <property type="entry name" value="SET DOMAIN PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17907">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00570">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51215">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AWS" evidence="11">
        <location>
            <begin position="431"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="9">
        <location>
            <begin position="489"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="10">
        <location>
            <begin position="752"/>
            <end position="768"/>
        </location>
    </feature>
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            <begin position="70"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="144"/>
            <end position="231"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="335"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="927"/>
            <end position="970"/>
        </location>
    </feature>
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            <begin position="983"/>
            <end position="1109"/>
        </location>
    </feature>
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        <location>
            <begin position="82"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
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            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
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        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
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            <begin position="357"/>
            <end position="399"/>
        </location>
    </feature>
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        <location>
            <begin position="667"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="781"/>
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        </location>
    </feature>
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        <location>
            <begin position="795"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="934"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="949"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="983"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1033"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1047"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1070"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1100"/>
            <end position="1109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY13443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1141" mass="123545" checksum="BA2A66152F643378" modified="2018-09-12" version="1">MCSPYWKPATGTMTRKPFEWPQFPDAVRFDFDLPAPLHQDVPAAVVLVAATAEPQQQPAQAQAGAAAGTVGASSSRADHCGEATSASANAEASAFMQDAAPSPARPATSTSTSSSASKRLADRFVSTAKYYTPDLMDRLLQGEPVALPPVRQQRRQSSLRKSSTSMHSTNNKRRRASSAASSSTSRVKLEPGAAEDGGGSSVAAPEDTTTAMTTLDGTPASTVKSERAAKSRRTGGSSIGWAYIIEREDDKDYLDCGLYYEPAIQNREEHRARRVRKARIKYTAEDLDYLSIDAETELNWAPRNYGWFLLEEERDFRLPFNIMRDHYGAERKAHPELNSIRIRELTPTPPPTPTPEPVEEEPEEEEEEEEEEEEEEEEEEIEEEPEPEPEPTPEPEDPEVIQARFEASRKPERFRYLYKNVYVNRRPWKADSVMICECEPPEDPEEYGCGTECINRMMQYICDTKTCPCGDRCSNVPLKRRQGIPEGKDGLLVVWTGDRGFGLKTLVDIARGQFIMEYRGEIISRDESYKRVLTTYKDAKSYYFLDYDGYDVIDAGMRGNASRFINHSCGPNVKVVRWKMAGYEEYEIGMYAMQDIPAGTELTCKHGTRLPPSRVLLSSRAGAPCAFTDNYGWQDFSDIKSNPNVVALATAAAAAAAAETALAAPAAAPAETTSTTPAATPAAESADESGSDLASSLLGPVASTSSHSSASTFKAVLPNGESIVQPNPESIAATTPSEGVTPAVVTATSAPARQPCFCGALQCSGILGGKKKSLVSILLSGSSSSAPNSKSNGKAGDKSRSKGKKDSAATTIAAEERASPAGTPVLSASQTYSAAYNSFLIEKVIDAPTKGSFELIFSAAELAERERRLQRKQEREQMRLDRELKASARDSENVSSMLLSRVNINHEEPIEDGEKVTRQAEDVEMRDVEEAEAIPEPISTTPITTPRPESLPPLHPTCPTPPPQRNGANNEMRLSSVAESYFSGQESDWTNTSNFRSRSHSGSIGPSVGGTPPPMQAPSTISNAGHSPCVTRKGGGSRPGGGGGGNKSKHSEKRGRGRPRGTGKLQLAAKKAEREQQKVDKLARKAAREEKAAMKAQQQYDQQHTLAASTSSTRLISTGVNAVLNAGPSHAGPMVTPQAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NTQ9</accession>
    <name>A0A2X0NTQ9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C010g05836 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C010g05836</name>
        <name evidence="2" type="ORF">BQ5605_C010G05836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NTQ9"/>
    <dbReference type="STRING" id="796604.A0A2X0NTQ9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052917">
        <property type="entry name" value="Stress-Dev_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038725">
        <property type="entry name" value="YdaG_split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34818">
        <property type="entry name" value="PROTEIN BLI-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34818:SF1">
        <property type="entry name" value="PROTEIN BLI-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16242">
        <property type="entry name" value="Pyrid_ox_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="General stress protein FMN-binding split barrel" evidence="1">
        <location>
            <begin position="20"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY13330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="203" mass="22074" checksum="C66D480F7E1BE4FB" modified="2018-09-12" version="1">MSNDPYTAKAASNASPAEKIKELRDEVIKSSKFAMLTTRSKDGTLHSRAMSPASDKGLVFVFIANNESGKFDDLEHDENVNISFSDASSTNWASVSGKAKTMTDPESIKPFWNPALKAWFGDLGGEKNGTYTDPRVSAIPRLSARIVQEVRPSEINYWVSTRTSIGQVLDVAKSALTGETAAPGHLRTIYGSDLEIAKTSEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NUP5</accession>
    <name>A0A2X0NUP5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">BQ5605_C018g08741 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">BQ5605_C018g08741</name>
        <name evidence="17" type="ORF">BQ5605_C018G08741</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY26509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NUP5"/>
    <dbReference type="STRING" id="796604.A0A2X0NUP5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009160">
        <property type="entry name" value="Acyl-CoA_deSatase_haem/ster-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000345">
        <property type="entry name" value="OLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="16">
        <location>
            <begin position="407"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="SGY26509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="546" mass="60439" checksum="785C286220102511" modified="2018-09-12" version="1">MSVTASASHKLAASLPHGDGQVSASTTARSTAPLRMRHPDKGEASDSDSDHGTDSDGETTAVDDGYAEDNYVRKVLAKERPLPPITLKTLPQNIQVVSTLALTLVPLLAVYGAFTTEIKWQTMVWSVVYYFFTGLGITAGYHRLWAHRSYTASRPLQYFLALGGSGAVEGSIKWWARGHRAHHRYTDTDLDPYSAQKGFLHAHLLWMVLKPRRAPGTADVSDLSSNEVVKWQHRFYLPLIVGMGFVFPTVVAGLGWGDWRGGYFFAGAARLTFVHHSTFCVNSLAHWLGETPFDDKHTPKDHFLTALVTVGEGYHNFHHEFPSDFRNAIKWYQYDPTKWFIFTMFKLGLASNLQTFPDSELARGQFNMKLKKLAASASNLPWPKSSNDLPVLTWESFQEEAKSRDLLVIGGFIHDVSQFMDEHPGGRGLIKSRLGRDATTAFYGGYYDHSNAAGNVLARLRVGCIEGGYEVEALKKYSQIIEDIKRYGGDGVAGKTADMGSSARATVAIKGDPAHRGSKLDTLKDYPTFKPEVLPLNGGLTQSLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NX35</accession>
    <name>A0A2X0NX35_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C014g07450 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C014g07450</name>
        <name evidence="2" type="ORF">BQ5605_C014G07450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY18722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NX35"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY18722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="650" mass="71838" checksum="75269377EFE1AC1D" modified="2018-09-12" version="1">MDSKVFCAELVQTARVRDCESPSSHQFSVASSICSSEESNTHESDDLLGHDDSVLNMEAGRVFKSPLGKIDLDFDDVTSSVTERLSPCPFKSILLVHRCEVPTIWPSPSKFRSATCGVTAYEYNGDLFLSLPDVFTGARNMCLWRGPHPRQSTVSPFAIERNTDTNSTFDWVPIADDACGRYSLGGFSGSGSQNAQQLRILHPSGYRYIFTPLLLLFWRYFSQIIFTRFEVLGDLLCTVDLPPIGHSQDPVVLRASATNPKRGMLLTTTCPPQSEVLERLEPDSCPTSAPSVGSTAPAPHAAKAQDAPDYPATLPFYMRLDASGAPLFDLFLSELKPKEIRNAYVPNGTWTTPIRVERHGSNTSPIIQPIFAYSKQSGSRYRKRPHHNKYPHLSTKVMTVKPKCLGAHICANSDCLGIDRPKGTSSVGSRSNTVLAGDGPKRHTHSTSYTLVAQLDDSDLTPAELADPNFETCGMAATMVIIRHQLTHPIPLLRKFMPQPYVTAQASTLLYCARGTMCLTLSLLHISDPRLNMDKFHGRHDSSPDLDTAAPDSANTTPVWIALQGLVRIQPHYLAYQTADKKGDLLSLGIQTPEMRAWARWVPILHSIGRSEDSETYRAHFDHLYQLADRTGKSTIDARDFKLVLDFSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NXH8</accession>
    <name>A0A2X0NXH8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C015g07896 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C015g07896</name>
        <name evidence="2" type="ORF">BQ5605_C015G07896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NXH8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="406"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="441"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY17805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="538" mass="56485" checksum="DF9CC07C86B36C82" modified="2018-09-12" version="1">MAVAVQAPTRSIHSLGHATLESDMRAGLATSAVVSSPSTASALSSSSSSSSLSEQGRSPYARTQQISSKRQRYTHQDESIWTETLPDHVHTPQPLAEDDLEDILAMPVAVELKPRRSQVNLLHSSSNQNLRSPASSAPPLSPSFHTSASPWTAHSNSPARSPASNSKASNTTSQTATNRSIQSHTSRARSRSQSRIARPIDLVAPPLPSRSAPPLEKENRNETEGKEESEEQIEWETLQVAEPITRIPTEPAVQPIGGITSDAPAVKFPSGKAVTPRQSPTLSSGTTGRTARNAPPRTPANTNAPLRATPSPSAGSPISGGPRKSKASPSSSLNSRTRTRSAAPRPQKTSPYLDDADALPDATPPWMAAPAPIVFRSGEDGSLRGQGRVDEMVLPAVARRLEAERLTAASSTTSSLLITEWDAQGRPVRAGDVLSPLTKQSSGGASPSPSANEPTTGFGKRGAADALGAGNTRPQVALKPLSRTSSLPHPIPAPVPSPPVPTTPVRRPERPSTPQQDLTINGEEIISKKGLCGGCTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NXJ1</accession>
    <name>A0A2X0NXJ1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C014g07610 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C014g07610</name>
        <name evidence="6" type="ORF">BQ5605_C014G07610</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY19304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NXJ1"/>
    <dbReference type="STRING" id="796604.A0A2X0NXJ1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF34">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY19304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="229" mass="24741" checksum="B35B14164CF0B391" modified="2018-09-12" version="1">MVYEGTDGDSLAKYESSEVSVAQASKSGPKRSYTLSSTVADAHARTVAKLNAPPAPKEVNNALVYLIGITICMGLLGHRRHSIYCFGYNSVPLTLVSEIFTMRFKTISMTFCLMWQWLCTFAVVRIMPVALTNLGGKAYFPFAAIFITAGPFVYFLVPETKGLPLEAMDDLFGVAEMTDAERAVLANEKGEVGSVSHVEHAGYASAAAGVARSNTVQVMAPIDELARRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NYM0</accession>
    <name>A0A2X0NYM0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g02336 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g02336</name>
        <name evidence="2" type="ORF">BQ5605_C003G02336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY40196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NYM0"/>
    <dbReference type="STRING" id="796604.A0A2X0NYM0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013169">
        <property type="entry name" value="mRNA_splic_Cwf18-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31551:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31551">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08315">
        <property type="entry name" value="cwf18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY40196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="169" mass="18901" checksum="E8F36C2DC60D4E1A" modified="2018-09-12" version="1">MSSTPLQDAAEARKAKLAALKKRKTLHDSGAPISFNLDLDGDHDAAPSDVFQFRNYDPTTGTARKHARTDELDTVEKQVEGLADQVIARDEATRVQELDLTNIQPKKPNWDLKRDLDRKLGRLRHKTDQAISQLIRKRLQAEKGTEAAAQVGLVSGFDDRDEDPESDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NZA9</accession>
    <name>A0A2X0NZA9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein mS41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C019g08822</name>
        <name evidence="6" type="ORF">BQ5605_C019G08822</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS41 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY22582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NZA9"/>
    <dbReference type="STRING" id="796604.A0A2X0NZA9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039603">
        <property type="entry name" value="Ribosomal_mS41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019083">
        <property type="entry name" value="SAM_Ribosomal_mS41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28235">
        <property type="entry name" value="PROTEIN FYV4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28235:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09597">
        <property type="entry name" value="SAM_Ribosomal_mS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01238">
        <property type="entry name" value="IGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small ribosomal subunit protein mS41 SAM" evidence="5">
        <location>
            <begin position="63"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY22582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="148" mass="16397" checksum="6C920BDE2CA3BABB" modified="2018-09-12" version="1">MASLTPALRTSLRLTRPGRSTVASASSWHTTPLASSSSQLRSLHAPALAPRRIPSTRTPYTTPAAVLESASRNLKQHTDKFPTWEALFASTSHSLAELGLAVKERRYLLWVLEKYRAGFDIAEIAVPTKPKRKIRGWGPKVQNGKRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NZF3</accession>
    <name>A0A2X0NZF3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">holo-[acyl-carrier-protein] synthase</fullName>
            <ecNumber evidence="1">2.7.8.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C019g08882</name>
        <name evidence="5" type="ORF">BQ5605_C019G08882</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.8.7" evidence="1"/>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY23012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NZF3"/>
    <dbReference type="STRING" id="796604.A0A2X0NZF3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055066">
        <property type="entry name" value="AASDHPPT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050559">
        <property type="entry name" value="P-Pant_transferase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215:SF10">
        <property type="entry name" value="L-AMINOADIPATE-SEMIALDEHYDE DEHYDROGENASE-PHOSPHOPANTETHEINYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215">
        <property type="entry name" value="PHOSPHOPANTETHEINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22624">
        <property type="entry name" value="AASDHPPT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="4'-phosphopantetheinyl transferase N-terminal" evidence="4">
        <location>
            <begin position="24"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="4'-phosphopantetheinyl transferase" evidence="3">
        <location>
            <begin position="129"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY23012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="288" mass="33012" checksum="54F1EBA88942E7AB" modified="2018-09-12" version="1">MTLPPASTLQIHAVHVPTTLPDHEAYRSHLHLLRHDPEAVQEIQRYRLIDDSKRALVSRLLPRYVLALQGLDWRQVRFEKGEYARPLAIHPNLPKDFQYSASHDAEWVICASTFGTTEHGQDLPRVKNVGVDVMRLAIPWENVDQEGMLDIMKDHLSPTELAHIQSDPNPHLETLFSYWVLKEAYIKARSLGLRGFPELKRIEFHLDPKASDASWEWKTVNGSLDRVQLDGWWFGLKTFDGGRYLLGVALELDGAGQVEEPSWEVDALDRATILDTLQCRWCELQSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NZL8</accession>
    <name>A0A2X0NZL8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C001g00201 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C001g00201</name>
        <name evidence="3" type="ORF">BQ5605_C001G00201</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY44790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NZL8"/>
    <dbReference type="STRING" id="796604.A0A2X0NZL8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004729">
        <property type="term" value="F:oxygen-dependent protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF3">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="86"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY44790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="648" mass="71493" checksum="211D10E2C67010AB" modified="2018-09-12" version="1">MSRRVMTRLRPWPRPATSLIALASARSLSSQPTGAAPLCPPRRATTPLRRTPQPITHSKCLSSSTRTQHPDAPPPQRTVAILGGGLSGLSSAFYCLRALPPHLRQSTRIVVCEKQERVGGWCRAIKVPLKGGKQGDQLVFETGPRSIRPVGLMGWLTIEMVSLQTVNLSYSISQTENGFPLAFLTSQAHTIGLTPRILTVSKSAPSAKNRYLFIDRSLFLLPSSLWSAFKSLFSLQTNLMRRVIPSILLEPFRPRSPLHSTPDGGDESVDAFFSRRFGPVLASNMISAMIHGIYAGDTRRLSVRAIFPALWEAEREWGSVILAALLGGVWRKRGWKPKSAYRLGVEREAVMMEEIKGRLVQSGEEGKDLVERMSGASVWGLKGGLEELTFGLERWLREQGVEFRLGEESQVERTREGEWTIKTPTTTLHPTHLITTLPSLLPDPISPPPIPATTVSVINLAFPTSPTTPRLLPPGFGYLIPRTVPRNENPYQALGIIFDSDVMPHVDACSTSSPTSEGLEKISLLLGGSYWLDNHPPPSPSHSDLVKQTLQTLQLHFPSTSFPPPSYAFSTTHQHCIPQIPPYHFLAFRQMGRRLRQERRVRVAVVGGGFATVGVNGAAKAAWEVGEGMARDVRGEEGYRTGTEMWDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P1B2</accession>
    <name>A0A2X0P1B2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C002g01248 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C002g01248</name>
        <name evidence="3" type="ORF">BQ5605_C002G01248</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY31653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216:SF65">
        <property type="entry name" value="PAXILLIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="894"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="394"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY31653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1455" mass="160289" checksum="4555DD24FE2F0C8D" modified="2018-09-12" version="1">MDNNNNTNNASHAAIPPLRPDPPDPPGQAPATTTKSYSAAVGARSATKHGNATANASTAVAAHPLMHNIENCVIINTPPSTSVEQVLLALDKYYPGLTGAMPCVIKGQRGLRFPKAADLDTLVANGLTVGKTLCKVEKLYSSTKGGVVQCTLTGFFSDPEGLCLFDEQIAAYGTVLRRRIQYIGKTKHISGVYDFILALKDVDVLPPASLSIARDGVTERIPLRITGGMRHCVFCRSAAHVRKDCPVAPACKSCASTSHATQHCPAPSTVTTAAPAAVSKSISPASAHDRTTKKRRVEQDLAAQTEDLSNRAQPDSLSKNARPEFSFNFPCKTATPPAPQPASNQGIAYSLVKKSSESPSSETTSPSPSPPPATPKSIITRSKSIAALSKPATREAPPTAPALEASEPSPEPSSPTPLPSAAPKARPDDADTDDEADEEAEDQEAPPKDSISEDRKRASLFSNLRSHNADVFLLSETGRPSPERVAQWTQECQDLKLSALFTPFNNTAILWKSDSVVITFDPESPPNTLRASFSFPDRVTDATFCVGDSKVRVVSIYAPSSDKPDKKRFLSHLSTALRQVVRDEPSPPALLVGGDWNCVESQPLDSENQNGTNYRGQEMRDLATANNLFDAYRLHHPKGRATTNRSAPGTCRRLGRIYVSPDWVDLFHVHKIWAPVLKSTHSMVVARFQVPGAIDIGPGKFKLGLHVIEGDATCEYLTSIVRTLYNKALLQTPNDPPAAWTSTKHRLLPELQALARTFARFRRGGSEQERADHSRYGAALRSRLDPSLAGPSSIFIRLRKVRASDLIPSLTVNDVVHSDPDSMLGAASDYFERVYEDRPIDDAALKAIIDGLASTRLSPADSLKLEEAYPLEEMKKAQAAFLCAVGLGPKARQWYRATYTNQSASIFLNGWLSATFDILSGVRQGDPLAPSLFVLAIEGFACQIRLRVKGIDIAGLQNVRELLFADDACCALHNLSDLDHLNRAIELYERASASKLSNVKSFLYPLGAFRDRSIAPDLGTWRLSDSQFRYLGIQVGVEIAEDAGWEDVKASTIARIRSVPMYDLPYAAKCSIINIYCYTKILYYSRFLPAPKSVVKEIEEAAMLAIHGRASDGTQRRPKVSRSRLCTPLDHGGFGLIDLPRRLAIDHAKWVFQLRAPDGCFTRHLFDIRIRLQAPNEPTPFTLSRPAPNQHRCPWIWIWWAYFCHPPPKWDHAVRKTTKLLPARWVRYFEAWALVTTLNPPELSKSQNLEQWATHVLYFPAGHGIQLSVNPRLFRGPDGEVMTPSSFVNAPKRHKVFIFPPIFPKGHQKVFDLPEQRWNAWWKALRKVRRVHSGAEDTGHLLSLGSLHPGSQVASPTSPHPSNRSNSCVMCLSEAPECLVHLAVGCPFARRLWSALSPTPHPVFVDFVCPVVSRSERRLVELRVLFFHSIWKLCRHRRFSSDLLEPITETEFEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P236</accession>
    <name>A0A2X0P236_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g04207 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g04207</name>
        <name evidence="2" type="ORF">BQ5605_C006G04207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY56999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P236"/>
    <dbReference type="STRING" id="796604.A0A2X0P236"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY56999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="977" mass="105680" checksum="8CDA6AEE394BF92C" modified="2018-09-12" version="1">MYDRCCRGRGYEPSPPPSPRPQMEQAAATTPSFQSMRKTKASRSVGGGGEGAVEADLGAGNGNGNGNGSAGDEIRLEKEKEKEKVKEKKEPKSFQILKYPIHRQTSPHPPRVLSYSPHLREGHPNRARTTSPPLLPTTATTPTPHQAEHTAAQHAMKGSTSSSSLAGVAAVSATGAAAAIGLAGGNTDAVGAGVGSGGDAETARPFRSSSRQQQPQPQPPQQQQQYSQQPLYQSHQIQPQQSYASFASITLSRTGIPMSEQQGTPPVPSIPNGYIPQHPSNHPHAQQSASASVMRPAPLYASPPVGYPTPPPPIQTYSSPLPTTSPVYNVDTGSAAANSVRARMQDPGNEGKLSVGIDFGTTFSGVAYGSTRLFAGQIRQILVWPGSYETYRKVPSCILYHQPSPNEEASVLSWGLEAKNTALQPGMVKCEWFKLLLSPESLRSGRPDPRLPPLPHGKDVVDVIADFLRVLWRYAKKQITEEIGSVVDLDSAEVLLTVPAAWDAAGCNLMREAAIRAHLVQSSRGGDIHWRDRLQIVTEPEAGAIHASTLASLHHLRPSQTFLLCDAGGGTVDTAVYKLMGQLSQLEIAEMCVRSGANAGSLFVDLMFEELVRKILKDHPVHLDPPSLTSFMHAFSESDKLDYHGRVDDGKMLADSMYRFNCFNVEDGHDPSVGLEYGELAIPGHVLKVEVFDPIINQVLDLLHHQLSKVAGTRIDAIILVGGFAASEYLYTRVQEEFGASIPVIARPNDCDVATLRGAARYGLGLTQGRKAVSAVITPRSYIMSECEALDVSWLGGLRSLMGRLSFRIAEVKLPAEDVDRYERPHFITINDAGMEVCANRLSCESLDSRHNRRASSLTRPNPLTDLVAKGAVLRKGEKLRSRFCKFVKNANDSTFTAQLYTSDSDELYRYTDEGDATELCRWTVDLAALPSFAQIAALGGGYVEFDLGLSLDSAEVRGVLMSDEGVDCGTATFEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P2T5</accession>
    <name>A0A2X0P2T5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C003g01841 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C003g01841</name>
        <name evidence="8" type="ORF">BQ5605_C003G01841</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY37596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P2T5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF198">
        <property type="entry name" value="AZOLE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="552"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="585"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="646"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="120"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="43"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY37596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="689" mass="73862" checksum="017A89BB7F482357" modified="2018-09-12" version="1">MDAPAHSTTHAGDLGIAPFSLPTLSAIHATVANEEAHEIAHPTVEHAPDGTANPAISKRISSGSSSSQQEKRSSSSIATPPRSAKDVQKFGAGVIGEDGFTDEERLRESKYLTGKKLAIVFIGMLMSVWLIALDQTILAPALPVRILPRNKYVLCETLSSSSLSHAKQVIASKFNALDQIAWIASAYFLTQTAFLLLWGQILTLFDRKWSFLVGISLFEIGSLVCAVAPTVNVLIFGRAFAGVGASSIFVSCLSIIAEVTRLEDRPKLFGLFGAVFAISSVIGPLLGGAFTDHVTWRLCFWSQYIHLLHHVRGHRLTLVGRFRRAVNLPFGAVTVAAILFILGPQPAPPPSPKVIEFTTNKIRRWTFGKATFAPESFVFRLAVIDWLGTWLMLATITCLLLPLQWGGNKYSWSDPVIIGCLCAFAALVIIFVFVEWKVAGPTSILPLRFFRNRSQIGACLEAFCLMFCLLLATYYLPIFFQATKGVSATKSGIDILPYMLGVVVGSAVSGVIVSKEGHYKPWLFFGPWLLCIGAGLLYTIKETTKNSTLIGYQIILALGTGACLQQTIIAVQADCANPDDVPQATALVTFAQLVGGTIGIAISSTVFGSKLSSALKEFAPTAPFDLVRNSVEAVKTLPADIKPAVIHAYVIALNNVFVIGVAAGALASLSALLVRNLSVKGQAIGAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P365</accession>
    <name>A0A2X0P365_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g02050 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C003g02050</name>
        <name evidence="1" type="ORF">BQ5605_C003G02050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY38588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P365"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY38588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="69" mass="7456" checksum="DD2BEF77919BDDFF" modified="2018-09-12" version="1">MQPSACTCQCCASFGFDCVSLKEPRPTLDVPASEVCFPFACTCQCCASLLFACISLKEPRYITPLQALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P418</accession>
    <name>A0A2X0P418_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C003g02360 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C003g02360</name>
        <name evidence="4" type="ORF">BQ5605_C003G02360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY40365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0P418"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635:SF196">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="392"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="873"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="332"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY40365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1560" mass="172289" checksum="D9C4FE4EDDED4925" modified="2018-09-12" version="1">MDNNNNTNNASHAAIPPLRPDPPDPPGQAPATTTKSYSAAVGARSAAKHGNATANASTAVAAHPLMHNIENCVIINTPPSTSVEQVLLALDKYYPGLTGAMPCVIKGQRGLRFPKAADLDTLVANGLTVGKTLCKVEKLYSSTRGGVVQCTLTGFFSDPEGLCLFDEQIAAYGTVLRRRIQYIGKTKHISGVYEFILALKDVDVLPPASLSIARDGVTERIPLRITGGMCHCVFLEQDLAAQTEDLSNRAQPDSLSKNARPEFSFNFPCKTATPPAPQPASNQGIAYSLVEKSSESPSSETTSPSPSPPPATPKSIITRSKSIAALSKPATREAPPTAPALEASEPSPEPSSPTPLPSAAPKARPDDADTDDEADEEAEDQEAPPKDSINEDRKRASLFSNLRSHNADVFLLSETGRPSPERVAQWTQECQDLKLSALFTPFNNTAILWKCDSVAITFDPESPPNTLRASFSFPDRVTDATFCVGDSKVRVVSIYAPSSDKPDKKRFLSHLSTALRQVVRDEPSPPALLVGGDWNCVESQPLDSENQNGTNYGGQEMRDLATANNLFDAYRLHHPKGRATTNRSAPGTCRRLDRIYVSPDWVDLFHDHKIWAPVLKSTHSMVVARFQVPGAIDIGPGKFKLGLHVIEGDATCEYLTSIVRTLYNKALLQTPNDPPAAWTSTKHRLLPELQALARTFARFRRGGSEQERADHSRYGAALRSRLDPSLAGPSSIFIRLRKVRASDLIPSLTVNDVVHSDPDSMLGAAGDYFERVYEDRPIDDAVLKAIIDGLASTRLSPADSLKLEEAYPLEEMTKAQAACKSNSSPGPDGLPVEFYRATWPATGPILRDVINSIPTEARQPGPLPRNTAHIHLIHKRGERDQLSNKRPISLINADERIISQAHNQRLAPLLESLIGPTQRGFVPNRWIGTNIAEVQCLMDPGLPGSTPVSGMLAVMDFEKAYDRLSHPYLDAVLCAVGLGPKARQWYRATYTNQSASIFLNGWLSATFDILSGVRQGDPLAPSLFVLAIEGFACQIRLRVKGIDIAGLQNVRELLFAGDACCALHNLSDLDHLNRAIELYERASASKLSNVKYFFYPLGAFRDRSIAPDLGTWRLSDSQFRYLGIQVGVEIAEDAGWEDVKASTIARIRSIPMYDLPYAAKCSIINIYCYTKILYYSRFLPAPKSVVKEIEEAAMLAIHGRASDGTQRRPKVSRSRLCTPLDHGGFGLIDLPRRLAIDHAKWVFQLRAPDGCFTRHLFDIRIRLQAPNEPTPFTLSRPAPNQHRCPWIWIWWAYFCHPPPKWDHAVRKTTKLLPARWVRYFEAWALVTTLNSPELSKSQNLEQWATHVLYFPAGHGIKLSVNPTLFRGPDGEVMTPSSFVNASKRHQVFIFPPIFPKGHQKVFDLPEQRWNAWWKALRKVRRVHSDAEDTGHLLSLGSLHPGSQVASPTSPHPNNRSTSCVMCLSEAPECLVHLAVGCPFARRLWSALSPTPHPVFVDFVCPVVSRSERRLVELRVLFFHSIWKLCRRRRFSSDLLEPITETEFEGLRASIQESKGRLVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P6P4</accession>
    <name>A0A2X0P6P4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C001g00686</name>
        <name evidence="14" type="ORF">BQ5605_C001G00686</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY48728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P6P4"/>
    <dbReference type="STRING" id="796604.A0A2X0P6P4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000008">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="12">
        <location>
            <begin position="16"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="13">
        <location>
            <begin position="96"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGY48728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="134" mass="14191" checksum="EF5E02ECD14C1B57" modified="2018-09-12" version="1">MSSGGKSGGKAKAGADSKTQSRSSKAGLQFPVGRIHRLLRRGNYAQRVGAGAPVYLAAVLEYLAAEILELAGNAARDNKKSRIIPRHLQLAIRNDEELNRLLGAVVISQGGVLPNIHSELLPTKSAKAKASQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P789</accession>
    <name>A0A2X0P789_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C001g00866 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C001g00866</name>
        <name evidence="8" type="ORF">BQ5605_C001G00866</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY50255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P789"/>
    <dbReference type="STRING" id="796604.A0A2X0P789"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF2">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="7">
        <location>
            <begin position="293"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY50255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="520" mass="57822" checksum="63DDF97313D889F6" modified="2018-09-12" version="1">MDVDIPADTPSQVTVVEVGAVPTRHSASSKVLVSLDDPYDLEQVTGNYQGRTKIMHLLYIAQLSPSLAAPALTLALQELKASTLDVPTYEQAFHQYRQVLNSIESGELNDPFARAWYEGTIKSGAQPAQVMDREWCERTRKEASSGLEKLQVELKGYSTNLLKESIRMGHRDLARFQYRVGDLTAAEHSYLRSREFCLTSQHLLDMSVAVIEIALLLRNYSHVHQWTGKAEGALESMHSSANAQNAKQKPQVNLPGMVAPAQDPAQIAREKERTAMQERLNVANGVAYLGHGTYDRAAFLLSGGGKEAMHSAAGHFIPAADIAVYATLTGLATFNRNQLRTRLLENDDLRPMLELEPYLRDIIQAFHSSNFKDGLEGLEKYSTRQRLDPHLAPHLPNLMHQIRSRALLIYFTPFASVSLPRFAAAFGWSETTLLESVVELIGQGHMKARIDSQNKVIVAKHTDARVEAFKHALKEGEKMQRCQQAAELRVKLIQSNIVVKASRGHTHQASHSQGQIEVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P7V6</accession>
    <name>A0A2X0P7V6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g03892 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g03892</name>
        <name evidence="1" type="ORF">BQ5605_C006G03892</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY54604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P7V6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY54604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="98" mass="10688" checksum="82C3E2E2760FFEF5" modified="2018-09-12" version="1">MSLVAGLASNTCVKRSGWLYALSFDPSAALISGASGSYVIMMSSGGFPCLTTHVIASWYRCVMSRGLFLNVEPKVIERPIGFGVKPLMPWVVVRRRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P8Y4</accession>
    <name>A0A2X0P8Y4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g04241 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g04241</name>
        <name evidence="2" type="ORF">BQ5605_C006G04241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY57228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P8Y4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="598"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY57228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="772" mass="86979" checksum="5BE5F279DD6578B9" modified="2018-09-12" version="1">MDILPHTPPPLQPRSASPKSTTVRRRRRKKVTSSNKDTFENGATTSVGTEEEAKTKKKKRRRLWTKRLRKREPSLSPDSELFEKTFGFNFGIFRSPTKRRPKRQPGPPLSPSVQRWAYRDSRRRRWQRRHRPSSTFHLRAKSIAGLHKSSSELWTDIADCATAWPLDTETGGFEHNFKPDSAPDYEPDYDFGRDFGGGYSSGPEHSPFHPDGASQAQAPSSLKRSQIERNAKKQRNRRRNARAEAKTRASKRAELLQAYLLMKKKAKEVLRQSGFVPSPDDEGWCDACHERRVTRKVRVVDLFFAGMRGLRYCPCYPEIQTLAAHGLLPTSSSSIRKREGITAFTFRTIEYLDTYWGVDPFGIYDMSEALILFWSSELSSEDPFNKKILEASQGPTVRQHLQAAMDEYRFMQQLQATLTAEFIGLSPRERLADVCPACFGPRIDEAGKSENDLDVIIAVDGNFQHRRFARATADPLKSRPALFLSPDKIRNEQALIDGSTEAGEQVPWCCWCRDECTANWKAADGGVTSASSNVVADTGLVAAVCRHDHCLRLCNLHQSGEKLVYPVSLLKWILEEVEVGETDCTTGPARTSDATNVGSSSGSGSHQSSSQDRSRVGVAYDIACNLSSHLRRLISSRYAQRNLLADHLPRLEFALSSMHAYAHKWSCQVDFDPRFLPSFGLTNAEGAERLWSQLRGMIPMNRSSSASHRLENINRRASAYNKQHLAELGSPKLTKLNSRLKNAIKLKAEANRVIAEVVNRSAEWTVATLLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PAR1</accession>
    <name>A0A2X0PAR1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C004g02736 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C004g02736</name>
        <name evidence="1" type="ORF">BQ5605_C004G02736</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY67026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PAR1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY67026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="427" mass="48857" checksum="86C95F9E1780D17F" modified="2018-09-12" version="1">MRNVMFKLELINRDIAACREDLACVNTIDTNKLIEQSTQLQQLAKQRQVLDDRLNSLRTSDINISVLDPGTSLPSSILTLWCDPRCPRLNISISLIGTDYEFACTLIIASRSLWDLVVQYRQGAEKLRLPCLGGKALGRKSMQCQLIGTKAAGLLVKNLNSLRPRLMKAVAMYNDEVKKYAAILANSEDSHSILRTRRVPPSAPEDLNELLKLDILAPLWNNGLYSHPTEPWAYDDDVRVGIPAVLSRARCQQEIKRLGWEVRRIGRWLISRRKRFQQVRQQSLQRDEQDDSAMMMLEQEEERLRNIARRWFSKGGLDHLWECTRQTGEPQVEEWVELRMWCTDDVDVFQRTTAGGLPDHTWPDCINDGMVGESDDITTDHDTLLDISDHSSDDLSHHSVDTTDYGAFSDEINENFDEDDGDVFWGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PBQ6</accession>
    <name>A0A2X0PBQ6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C004g02995 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C004g02995</name>
        <name evidence="1" type="ORF">BQ5605_C004G02995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY69318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PBQ6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY69318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="67" mass="7177" checksum="414C576CB1443973" modified="2018-09-12" version="1">MITKNLSQTFYLARRPGLPWTPLRSRAAVPKSATVVLATSGRGELTVADGTLLPTSTTYRLGAASMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PCG9</accession>
    <name>A0A2X0PCG9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C005g03297</name>
        <name evidence="12" type="ORF">BQ5605_C005G03297</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 9">Required for assembly of cytochrome c oxidase (complex IV).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the COA3 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY73489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PCG9"/>
    <dbReference type="STRING" id="796604.A0A2X0PCG9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041752">
        <property type="entry name" value="Coa3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018628">
        <property type="entry name" value="Coa3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09813">
        <property type="entry name" value="Coa3_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c oxidase assembly factor 3 mitochondrial coiled-coil" evidence="11">
        <location>
            <begin position="25"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY73489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="181" mass="19892" checksum="E626C71479BB8AA0" modified="2018-09-12" version="1">MSGPSTRAARATYHPQSGARISEGLARARRPFRTQNAITGALIFGFATAVYLYSIRAVAQDDFSDLDAPVQREGLRSLEDEQKERERLKAERVREWETSAVSTTAAPILETAQKVEQQVEERRGLLNGVVGKSVAGILVERGIWNGKGHASSIIPKAPDVDRIGTLWDNRARTVQEGPKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PDD1</accession>
    <name>A0A2X0PDD1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C029g10694 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C029g10694</name>
        <name evidence="2" type="ORF">BQ5605_C029G10694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ15703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PDD1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ15703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="307" mass="35096" checksum="710E093D4C399591" modified="2018-09-12" version="1">MLRPCGRTRERERKGPRAPAGEQGRRPKGAEKNYQLSLRFRLPSGLPPKYWIDKSRMETVSCPMLRNNALHNDSDEPVFKHVHVPLPPTDEPIHSSLLFEKALRYLNQDKPTYVIPTGDAPLWEPSDELVLPKLWPHLDPFGLVGFCVERNLKVSLDEQVNHLLNLYDSDFDATQSGSNRSSTARNRHGCCVRNDQKIKDTKRYKATTEAEKHTNRIMEELQSVGDKIQGTTAQMLDMRNEIRGNVNAFGILGRIKDKFLDQAGTSGGRFFFFFYILRTQNPGNCRGALQKIDILGRNTRFAPMSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PDG0</accession>
    <name>A0A2X0PDG0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C029g10724 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C029g10724</name>
        <name evidence="2" type="ORF">BQ5605_C029G10724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ16057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PDG0"/>
    <dbReference type="STRING" id="796604.A0A2X0PDG0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ16057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="227" mass="24672" checksum="CE622ABBA20FB65F" modified="2018-09-12" version="1">MRLARSARLSPEPSGEWIPHRPLAQPRGSLAVDLGRAGLLFVQIATLQAQLTALQASQPPAAAAAATPPVTATQANTATASKVVFPKHARLDGPKSFTNWLRQLRLALPNQARGYVLDGVIPLTWTADQLAARDNAAREIIVGSIDSADVSATLDTIPSDDLLAPRIFAALKAHFAPDDATRTLELFARLWDFRKMPASVKAYDMWLREYMSIAQEIRDAKTSLNNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PDX2</accession>
    <name>A0A2X0PDX2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C008g05139 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C008g05139</name>
        <name evidence="10" type="ORF">BQ5605_C008G05139</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PDX2"/>
    <dbReference type="STRING" id="796604.A0A2X0PDX2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03754">
        <property type="entry name" value="proteasome_alpha_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000055">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034642">
        <property type="entry name" value="Proteasome_subunit_alpha6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="9">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY79468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="314" mass="34723" checksum="7B5CF0EA65E22143" modified="2018-09-12" version="1">MPPLGANHAPVYGPRESEQCSRIAVYVEEAFTSPVTGLYPVNTTLARAPSRRRPLTLTTCSFSSACVRCTVSRTSFDRALTIFSPEGRLYQVEYAFKAITSSGHTTLAIRGEDATVVITQKKVPDKLLDPDSITHIYNVTPNIGCVFTGRHADARNQLQRALSEATQFRYKFGYEITPDLLAKRIANINQVYTQRAAMRPLGISMIIVGIDPELGPQIFKLDPAGYYVGFHATAAGQKQQEAINLLEKGYKKGWKLTKLDDVVELALTSLSTVLATDLKKGEVEIGVCGGEERRFRKLSTEEIDGYLQRLGEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PEB1</accession>
    <name>A0A2X0PEB1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Nucleolar GTP-binding protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C008g05108</name>
        <name evidence="10" type="ORF">BQ5605_C008G05108</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 7">GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
            <location evidence="2 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PEB1"/>
    <dbReference type="STRING" id="796604.A0A2X0PEB1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01858">
        <property type="entry name" value="NGP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000559">
        <property type="entry name" value="Nuclear/nucleolar GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1580.10:FF:000001">
        <property type="entry name" value="Nucleolar GTP-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024929">
        <property type="entry name" value="GNL2_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012971">
        <property type="entry name" value="NOG2_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF9">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08153">
        <property type="entry name" value="NGP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="9">
        <location>
            <begin position="256"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="512"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="603"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="530"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="603"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="656"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="684"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="713"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="728"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="760"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY79331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="771" mass="84937" checksum="361CE2619BE5DB95" modified="2018-09-12" version="1">MPRDTSNKDSKARNSRHAAATGLKTGNLKVKGSRTGQATTAADSYRFFSNLHSVTGENFYRDAKSARRVNMLSGKTGSAVRNAQGRVIQEAAFQSKDVTPGRVQPDRRWFGNTRTISQTALEHFRTSLKDKIEDPYAVVLKKNKLPMSLLTDAPSGKVKLDLTTTEPFSDTFGSKAQRKRPRLDVGSFSELADKVTAHQNAKRDAAKVAAADAILEAEDYEGSRNPEEIAAEVANNMLNDVPQDYILSAGTSRRIWGELYKVIDSSDLLLHVLDARDPMGTRCESVEAYLAKEKRGKKVVYILNKVDLVPGWVAARWVKILSKKNPTIAFHASINNSFGKGSLIQLLRQFSTLFSDKKQISVGFIGYPNVGKSSIINTLKKKAVCKTAPIPGETKVWQYITLMRRIYLIDCPGIVPPSARDSESAKVLKGVVRVEHLSNPADHITYLLERVRPEYLRRTYGISEWTDSEDFLAKLANKYGKLHKGGEADQRTVATMVLNDWIRGKIPFFVAPPEPDTREANGKPLPKPLNPSTSSNKLTKPIKSTATGGSETLSREEGVLANGLDKDGNTFKSVKGVTQPLHQIVHSTRFLDDDVKAIEVDEVVEDDGEEEEEEDEEEWGGIASGDEDEEEEFESGEEDDQIPLQWDELFAQAVGEESDASEDGEDVDEDEDDDDEDEEVELISAAGASSSSKPASSKKRAVEADSESDVDEATSKPTKEPRMKTNKTKATNYYTTANVKNKSRRGKPDTSGRVGEGKGTGKKRGGRKSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PFC9</accession>
    <name>A0A2X0PFC9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C024g09816 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C024g09816</name>
        <name evidence="6" type="ORF">BQ5605_C024G09816</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SVF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ26008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PFC9"/>
    <dbReference type="STRING" id="796604.A0A2X0PFC9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051385">
        <property type="entry name" value="Ceramide-binding_SVF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033394">
        <property type="entry name" value="Svf1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013931">
        <property type="entry name" value="Svf1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47107:SF1">
        <property type="entry name" value="CERAMIDE-BINDING PROTEIN SVF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47107">
        <property type="entry name" value="SVF1-LIKE PROTEIN YDR222W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08622">
        <property type="entry name" value="Svf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17187">
        <property type="entry name" value="Svf1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159245">
        <property type="entry name" value="AttH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Svf1-like N-terminal" evidence="4">
        <location>
            <begin position="46"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Svf1-like C-terminal" evidence="5">
        <location>
            <begin position="227"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGZ26008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="424" mass="45593" checksum="EEB1B2DDED350160" modified="2018-09-12" version="1">MSSWFVSAAPTGPNFAGVHRNFAQEAFYGPLVQEDTEWLCAGGFVTETQTFYATTEQGELIMCQVIHSSVGVWYPSIQFTFRYVNPTTSKHVWKSTAVTNFTVGGAKLDKRSSKSDQFTITVDPSKPNLYTIQGKYDDETQISLTYEALTPGWKLGAGPRGGMSYFGQLKPATTQPGTQPDLSGGADGYCVHRFWPRCAIKGILRLGTDVIQIEDARGTFIHAIQGMRPNVLASAWNFANFQSPASGGEGVALTMMEFTSCPAYGSQKVNIGSIVVGDKLVAVVAGGDGIQGGSVALHYEAVNDVETGYDAPGAIKYTWEGLTLSGEDDNLKPSASSNDISSAEIDQKLLTSKPGEPYATQGLVEKVDVLGQIPYLLKKFVNYAAGTKPYIYTWLNPVDAKVVTPGQGAKTVKGTLFSEATFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PGY0</accession>
    <name>A0A2X0PGY0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="1">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C037g11618</name>
        <name evidence="12" type="ORF">BQ5605_C037G11618</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peroxiredoxin family. BCP/PrxQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="1"/>
    <dbReference type="EMBL" id="FQNC01000062">
        <property type="protein sequence ID" value="SGY93942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PGY0"/>
    <dbReference type="STRING" id="796604.A0A2X0PGY0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03017">
        <property type="entry name" value="PRX_BCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050924">
        <property type="entry name" value="Peroxiredoxin_BCP/PrxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801:SF23">
        <property type="entry name" value="PEROXIREDOXIN DOT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="114"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY93942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="269" mass="28375" checksum="F14876681D27F89D" modified="2018-09-12" version="1">MAPKRPSTSTADSSSVPPVPSEAHSRRSTRSSLGGTGGATSSPTKDEEQTKTSSNGTKDKKGEEAQSTSKDAEASKVGAGKAGKAGKASKAGEIEQAAEEAEPAAKKAKKDGVYKRNDIIEDIVLQDENDSPVSLKSLYDASGTSLVIFSYPRANTPGCTNQACGYRDIHGEFIELGFQVVGLSTDKPGAQMNWKKVKNLPYTLLSDPKKELLSRLGATDAKKRCHWVIEKGGRLAEQDIGVKPASDPTNALNIAKALASTTKGKPTQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PI33</accession>
    <name>A0A2X0PI33_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C031g11001 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C031g11001</name>
        <name evidence="2" type="ORF">BQ5605_C031G11001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000068">
        <property type="protein sequence ID" value="SGZ07229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PI33"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ07229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="383" mass="42954" checksum="3838C5DC9ACDC7A3" modified="2018-09-12" version="1">MPPCRSLKPRNKSPKSISSPSTPIIHGPQNASFAFRTQEKMVEVAECMVALSLQSPDFDPSQHPLMGLTCAVRDTSIVDRALAALKKGVLEQPSRSKLSPALKSEMQDQDFKLVDLQDWLWGKEAREAEHREMMLIDRFHRCVQEIILPTVQLLSEDQGSNLATEGLDCCRNYSLVKGPGNQASSSTATNETLVTFVANNIEDGGEPVFSDGLRVHSEFLASFEARSYDGIDIRFVKLMLEGSEGRYLENLVMQSFFDTYAERSIRQAAWSVQEAKNGRFLIFFATPYYMLAELVTIDGKWHLLLDQVYTAVREDPTESADSDLEYRPFLALLLALFMDHKQGFKIDGPSEVIKDKVRTKVKELGGAYDPSKFSIRPLESPGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PIZ7</accession>
    <name>A0A2X0PIZ7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C040g11878 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C040g11878</name>
        <name evidence="2" type="ORF">BQ5605_C040G11878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000118">
        <property type="protein sequence ID" value="SGZ32476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PIZ7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ32476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="314" mass="34898" checksum="D9984642BCB2DEA2" modified="2018-09-12" version="1">MATTAGLPSQSPAPPPGSSNTIPSEISSLECLLTTLDRARQALPTILRSFSSNTSSNSIEALSRAYHSSSVEAVAALRTLGDQLTVLDPILVRAHKSQADDPTGILVKARVDHTQQLHAPDDTLWIQLNALAQHQRQKRLQQQQQIGKRFGTLSHSRSSRRTYPHEPATFAPPQNRHQLHAILQKWKVRHADNVLQCEIDQSGIDSAPETTEIKFVLRSVMKAYISIHWQTPTKSDDQGDPIAIPQVERVACFELNETKSSYLASQYVLFQNLTRTAMGLIEGTRSTFGEPVSGTQTDLEQVLVRKLFCFVFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PJ36</accession>
    <name>A0A2X0PJ36_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C030g10874 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C030g10874</name>
        <name evidence="2" type="ORF">BQ5605_C030G10874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000069">
        <property type="protein sequence ID" value="SGZ09452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PJ36"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ09452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="503" mass="55708" checksum="80614BC8C2958001" modified="2018-09-12" version="1">MSVEEGALAAKNAFSKPVRPPPGAIVIGSMWVLLVKRNAEGQIVNYRARLVARGDMQRRRGVHINSFSPTGRAASHRLLLALAVENEWETRQFDVSSAYLNGNLGGTEIYMRLPGGDIVRLQRALYGLVQAGREWYKVFTEWILSIGFTRTDSDHAVFVRKEGDRRSFLSIHVDDGLLTGDGDLDGVLCQLKARFEARSTDEASFFLGQSIRREGKTGAAIFNQGHFVDAILEEHHMANASPRPTPLAAPSTLRNRADSGFDPASIPYRAIVGKLLYLSGTTRPDIAFAVSKAARFCNDFTAEHWEALKHILRYLVGTRNFGIRYQKSFQPMSAILEGFVDADHGADPVTRRSVSGYVFMCAGGAISWIAKRQTLVTLSSTEAEYVAMSDAAREGIWLRRLLADLGFEQTAPTRLRGDNQSAITLAKHPAFHARTKHIGIHFHFIRDHIAEGTIEMVWVPTGTMAADVLTKGLGTQKHYQFVHAMGLIDSSREGASWRVVNED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PPK3</accession>
    <name>A0A2X0PPK3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C046g12259 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C046g12259</name>
        <name evidence="3" type="ORF">BQ5605_C046G12259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000112">
        <property type="protein sequence ID" value="SGZ30891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0PPK3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1032"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1616"/>
            <end position="1635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1624"/>
            <end position="1635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ30891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1899" mass="212834" checksum="AFFBBE3A7870ABA0" modified="2018-09-12" version="1">MLEMRINVGVVRPPSKEQIVAAFQSIVQQLSTKGHSCQLVQVLRVIHVDTAKAYAHTVGDFSAFIHFDDASLFQHPTTTLKEILPSRMDLPTRGLDVTAVRHDYEKEAPCARCHFAGHVERCPLMQAANRKEAEDLARHAVMRGAGMVGGGEQTGVGRAATTTTNNIRPTANNNNTSEVVAPSRALGTDQLESRNRFAGLEVEGGQEDDIEEEVAGKEGEEKEQVEEGDEDTGAKADDEDSDSDGNAGAGIDKAGGDGKDDDKDNDEHDDKDEQDDSSEGSERRGDDVMKDGAEEEDEEMETEVEEEVEQEQGVQDDSIMIIDDGQTTITTVSRESTPRSPLWPPLSPETLAKSLREGAEWDRANAEAAARVQAENEAIINAQLDAQEPLVRHQFAEWGQEDGQLRFINIRGTGSRSNKKMKRSQTVADLSDPSDDPVDVKRVLNRVKGRAGKEVAGQGKRVTRSMSAAAAMQVEGAKAKAEKGKGVEEEKRWSDHEPEDDILPEFPLFEDNITAKSTWNVRRCMGIPEKRRDIYTYLSTFKASAILLQEHFIKPELWQCIKDEYEGKAFISKHCLTLIPADSPLIDAEILRTHSALDGRILVTSFRLRGDIRILEINNLYAPVDTKQRLTFFDKLHFHRTQSTHLRLLGGDLNDCPLPAIDRRNQGRHGHHWPILIGKLDSPYTDCIRFKHPLTPSFTRPNIVRKRPKSFSRLDYFLLQRTHQKRLVQASTIYDHPKDLSDHRPVSIVLVLSDERGDAAQPNNSLPTTSNQLHRINAATFKTAAFQGMLEGWLEGASGEEPVGELEVVLGNCEKEGRELARREHRERVERMAVLVGRVQDLEALPVMGDEETAEWTRTTEELRRAVNERARQLRIRAHVPEIATEERLSRPVHAKLAARSSDSKITALRLPNGELTHDIDVALDHTQAHFQRLYNLEPRDRDHVERLRDDFLAPIRAARTCDDPSSDPLFLRRLSEAHIELLQQPITEDEVVAAIATTHPGRSPGPSGVPYELYHTAPRAWAKALSRAFNAMTERGSLSPKQGQGLVRLLFKHHKIGADRAELSSYRPITLRECDYKLFTKVYVARLNHVLPDLLPPQQHGFVKGRRSADASFHLRLLIEELGARGTEFPDAALLSLDQSSAYDLVEHEWIFAIFDALGAPATFQRVLRMLYSGDSTTARYIINGFLTPPVRLTCGLGQGDPASSSVWDVVFQPFLDALHRRGIALNLSLPTIHPYPQSRAITSLAFADDVVVAVAGSESLTLLDDLALDWRLATNGRLNTDKTVVLPIGCRWEAGDRPLVVKAEGESLEWIGLSFDPTGNTELANVNLVARLEAVLDSARDRGLTHHTRAFYVNRYAIPKILHILSADIPPLEVVKELDRILVDFVRGGKRRSCYGKDVVFTPRFKGGLGVMRMQDVVDSVAARVWDVLLGGSDAIWQGLARAAIVRTHPAPDFDLATDAWPCDYTPIRTDLHPRWQAVLKVPSTHNAQVKPRTLTLANLLALPIKLHTLHYLPGAPAVSRSPYDVDYAAFAIYAKVADLFRRELYPGGGFHLWTPPTDVVVSNSEYDQRGRPQREHIVAWYRHAINRLRFTPIAQPVAAVRINGPPRVRPTTPLESILPHPIDPPQRLPRPALPDQSTQYNLLSMDRPYTIRRVRRVLNAKAFTDTIGFRDSLQPDDLKGFWKGVNSKALTAREREVWFKLVRNFTPTRSLQFHQKHDDSPACLVCGAPKDDREHYFFDCDDSGNVWIAARSVLCDALGLDTIDNTHYTTLQRLFGLPKLKASLRDQEGAGRTIEIFTGLVLEMISSGRWGMQKWGTRMEGVGRRRIILEERLKLRAGGAWGRRGHFSHLLRWRVHQRFELDKVVAPPSLPSALRAFERDFLSRAGFVPGARDWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PQ39</accession>
    <name>A0A2X0PQ39_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C043g12098 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C043g12098</name>
        <name evidence="4" type="ORF">BQ5605_C043G12098</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000117">
        <property type="protein sequence ID" value="SGZ32158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PQ39"/>
    <dbReference type="STRING" id="796604.A0A2X0PQ39"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049492">
        <property type="entry name" value="BD-FAE-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF33">
        <property type="entry name" value="KYNURENINE FORMAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20434">
        <property type="entry name" value="BD-FAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="BD-FAE-like" evidence="3">
        <location>
            <begin position="157"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ32158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="466" mass="50907" checksum="5A1FFC0F9E91AC6B" modified="2018-09-12" version="1">MASAAAVGTRAPYTRARSWLATPLLVVLIPTLVAAILALPFLAVFSFVPILGFIALPSVLSIAVFSLYALPWILYLIFAQDDPPPSVPLPYLPYSPYKCLKITSASFQFLRDLIGSGYIALWFDLQIKRFAVLSGKDGSVYVQRNIPYAEGFTANKLDIYRPEGYDPVTSNVEAPVIVLVGGANWTLWNKTLGAQIALRLRRLGYCVVVPDLRQSPAKTPEMVTDLRLALEWVGDFIKGFGGDSDALYILGYGSGAHLASLTVVQDAVVRSRDKYTALHRTPASPGKLSTPDGSSPIQISAGIRRCSIWGEHARLPPIAGMILVAGVFDVIKQLRFEAKQGVEDISALRRVCGPSTSTSLLSCPSHLIYGAKEIVDPARLPPRFLIIAGGKDTAVHYTQSILLRSLLEGVGVPEVHLKLYRDLTHVGSLCSEYLVPRVRKITRLMHQTRYSPLFLSEIEGLISSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LVL5</accession>
    <name>A0A2X0LVL5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptide hydrolase</fullName>
            <ecNumber evidence="9">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C016g08245</name>
        <name evidence="11" type="ORF">BQ5605_C016G08245</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M28 family. M28E subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="9"/>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY21513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LVL5"/>
    <dbReference type="STRING" id="796604.A0A2X0LVL5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000042">
        <property type="entry name" value="Peptide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF56">
        <property type="entry name" value="AMINOPEPTIDASE YDR415C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015799477" description="Peptide hydrolase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="10">
        <location>
            <begin position="240"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY21513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="448" mass="48743" checksum="6E586DC5FE1BC3CD" modified="2018-09-12" version="1">MLVPLTQACALLALSSVALSAPVQQIPFSDTSIAQPKLSLASLNIEPSLRSRLDQHIASLPEKRLVQLADDAQPIEVTEGEKSILVMKGIRFVDVTEEDPALVAAAQVAIAGQGASKHTPFPAAVHFQTVPDLCSSNQTDAFPTKLSYSVKQAQPLFDTISLERMKTFLTRFSGFHTRYYRSSTGKQSQEFLLNHVKEIIKSNPKIADSISVKEFPHSWGQNSIILRFEPSSKASALRKKQGKEQVVILGAHQDSTNMFPFLAAPGADDDGSGTTTLVEALTVLVNASFIPSDHPVEFHWYSAEEGGLLGSQAVAQSYARDGKKVRSMLQMDMTAFVKPGTTPTYGIIRDFVSPEFTDLVALLIDEYGDISRTDTQCGYACSDHASWSKVGAPSAFAIESSFPDSNKKIHSSGDTIQNEGFSFEHMRSFVRLSVGMTLEMGGAEKLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LVR0</accession>
    <name>A0A2X0LVR0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C012g06803 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C012g06803</name>
        <name evidence="2" type="ORF">BQ5605_C012G06803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LVR0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY16209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="433" mass="48509" checksum="05277621BF6F1D70" modified="2018-09-12" version="1">MQSVQNQQYVSSVMPRPHTAGSRHRDDFSRCRLDGNVGEGPWASEVLHILPKTGNAASDSSEAIAEGKSVEVEQLVYLVTEKLILSSVQRFPTSLLDLPNETLEHICGYLDDEPSTEIRAAALRNMSLVCRRCRRPAQARWKPFRRIRLTLGQPNYSRFLALMPQSQTLWNVLRQSFASHPVRIEITLHPRKPRRIPSVFETTSFAALLSEIAEFHSFALQELAFSTLLGVPLSPLGKIKNLVFLALRGCSFTADPATITLPSLLRLQLNAASLLKLPRMELPALEDLVVYDLNQTATRILSADDLGWLLESTAATLRRLYLHPIQSDALESLLLPWLPSCRNISLIKLLVDEGSIADASTSIIHALPPHIAREEARLIDARQDDTDGESASLRHFFGQDRTRSHPNFRFPSDCVNHAQKIDRSLGYAMRTCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LX91</accession>
    <name>A0A2X0LX91_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C089g13036 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C089g13036</name>
        <name evidence="3" type="ORF">BQ5605_C089G13036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000032">
        <property type="protein sequence ID" value="SGY28049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0LX91"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1260"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="642"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="704"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1839"/>
            <end position="1864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="705"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY28049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2083" mass="231369" checksum="347B37881AD82C38" modified="2018-09-12" version="1">MQTGDPGSAPGARAPPPPASAPTSLPIAGTKETQATQVAGRTATYAAATNSSVVSNETPAQQQDRLARLQALPGILAAIQAVPGNRADRFVQAIFATPDFPSTVATALKFSALNATRNIINPFANALEVSLSHKSTGRASATDKGELVACVRTLLSPNTPICFDTGVPLSGDLEAFMPRITGLQHSSTFRTGVLHHRITVGFVSAEARDAALASAPMLVWNSANARFAKAHPFHRNMLEMRINVGVVRPPSKEQIVAAFQSIVQQLSTKGHSCQLVQVLRVIHVDTAKAYAHTVGDFSAFIHFDDASLFQHPTTTLKEILPSRMDLPTRGLDVTAVRHDYEKEAPCARCHFAGHVERCPLMQAANRKEAEDLARHAVMRGAGMVGGGEQTGVGRAATTTTNNIRPTANNNNTSEVVAPSRALGTDQLESRNRFAGLEVEGGQEDDVEEEDAGKEGEEKEQVEEGDEDTGAKADDEDSDSDGNAGAGIDKAGGDNKDDDKDEQDDSSEGSERRGDDVMKDGAEEEDEEMETEVEEEVEQEQGVQDDSIMIIDDGQTTITTVSRESTPRSPSWPPLSPETLAKSLREGAEWDRANAEAAARVQAENEAIINAQLDAQEPLVRHQFAEWGQEDGQLRFINIRGTGSRSNKKMKRSQTVADLSDPSDDPVDVKRVLNRVKGRAGKEVAGQGKRVTRSMSAAAAMQVEGAKAKAEKGKGVEEEKRWSDHEPEDDILPEFPLFEDNITAKSTWNVRRCMGIPEKRRDIYTYLSTFKASAILLQEHFIKPELWQCIKDEYEGKAFISKHCLTLIPADSPLIDAEILRTHSALDGRILVTSFRLRGDIRILEINNLYAPVDTKQRLTFFDKLHFHRTQSTHLRLLGGDLNDCPLPAIDRRNQGRHGHHWPILIGKLDSPYTDCIRFKHPLTPSFTRPNIVRKRPKSFSRLDYFLLQRTHQKRLVQASTIYDHPKDLSDHRPVSIVLVLSDERGDAAQPNNSLPTTSNQLHRINAATFKTAAFQGMLEGWLEGASGEEPVGELEVVLGNCEKEGRELARREHRERVERMAVLVGRVQDLEALPVMGDEETAEWTRTTEELRRAVNERARQLRIRAHVPEIATEERLSRPVHAKLAARSSDSKITALRLPNGELTHDIDVALDHTQAHFQRLYNLEPRDRDHVERLRDDFLAPIRSARTCDDPSSDPLFLRRLSEAHIELLQQPITEDEVVAAIATTHPGRSPGPSGVPYELYHTAPRAWAKALSRAFNAMTERGSLSPRQGQGLVRLLFKHHKIGADRAELSSYRPITLRECDYKLFTKVYVARLNHVLPDLLPPQQHGFVKGRRSADASFHLRLLIEELGARGTEFPDAALLSLDQSSAYDLVEHEWIFAIFDALGAPATFQRVLRMLYSGDSTTARYIINGFLTPPVRLTCGLGQGDPASSSVWDVVFQPFLDALHRRGIALNLSLPTIHPYPQSRAITSLAFADDVVVAVAGSESLTLLDDLALDWRLATNGRLNTDKTVVLPIGCRWEAGDRPLVVKAEGESLEWIGLSFDPTGNTELANVNLVARLEAVLDSARDRGLTHHTRAFYVNRYAIPKILHILSADIPPLEVVKELDRILVDFVRGGKRRSCYGKDVVFTPRFKGGLGVMRMQDVVDSVAARVWDVLLGGSDAIWQGLARAAIVRTHPAPDFDLATDAWPCDYTPIRTDLHPRWQAVLKVPSTHNAQVKPRTLTLANLLALPIKLHTLHYLPGAPAVSRSPYDADYAAFANYAKVADLFRRELYPGGGFHLWTPPTDVVVSNSEYDQRGRPQREHIVAWYRHAINRLRFTPIAQPVAAVRINGPPRVRPRSEVRPTTPLESILPHPIDPPQRLPRPALPDQSTQYNLLSMDRPYTIRRVRRVLNAKAFTDTIGFRDSLQPDDLKGFWKGVNSKALTAREREVWFKLVRNFTPTRSLQFHQKHDDSPACLVCGAPKDDREHYFFDCVDSGNVWIAARSVLCDALGLDTIDNTHYTAVQRMFGLPKLKASLRDQEGAGRTIEIFTGLVLEMISSGRWGMQKWGTRMEGVVRRRIILEERLKLRAGGAWGRRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LXC7</accession>
    <name>A0A2X0LXC7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g00976 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g00976</name>
        <name evidence="2" type="ORF">BQ5605_C002G00976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY28873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LXC7"/>
    <dbReference type="STRING" id="796604.A0A2X0LXC7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="193"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY28873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="555" mass="61864" checksum="58BF49AA418E40E0" modified="2018-09-12" version="1">MREIANAIKDVTGDGRLVGCGNSGSLIKLALDRGEQEKTPDAVILTHAAVAASPDLPFVWAQSEHPTSNDTKSAEARNQVLRRLHMTCTTALRAHAIGVTLCGEVLQVYLVNGCEVFTTSARKCGQEAVLLRRVLSHLIELDDNGLGMLASTNEVDDGFGNFIVSDKFLPPRAHDFEFGLGDISDLEIQELLFRRRSCLGRATSAFRVTARHAPVDPTSITSPNPAAEYAMTVAWVEQSRLDDAIALRRKMHAASRIDTEGLSLSAGIYQDDFRTLPAFFGDDESFDDIGPRALEVVFHRQCYRPLNTATTTRKLAQAVLGVVKGEHGNQLGGLAFALPSRHAYSHDNAGHRNLYRLGYIHRDISYGNAVIDHDGVGALIDYHLAVPHDRPCNELHHRIRSGTWPYLACSILAQPNEPLGVVHERWHDIESLFYVVMEISFREPYQGNNEELVMTPKGQIIWADWNRPEAHVVYTFKVVLRRDPAYRSVLQGCAHRWTNIRLLPDILRHHCGLDNQFNNFEVAEEEAQLGELWGPSKAMSHESIISDIEQLLPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LXR7</accession>
    <name>A0A2X0LXR7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C015g07887 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C015g07887</name>
        <name evidence="1" type="ORF">BQ5605_C015G07887</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LXR7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY17778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="107" mass="11998" checksum="2B5729E76247A14F" modified="2018-09-12" version="1">MEPRTRMADEVLRIDGEDKVGSECINHDKHEFGVGGRKRTCRIVGRVGAQGLTFVDLVEGLTGEEEASTDEEQAEKVECHHKQGRNEGQILWRDECQSAKRVTESSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LXU7</accession>
    <name>A0A2X0LXU7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C002g01146 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C002g01146</name>
        <name evidence="3" type="ORF">BQ5605_C002G01146</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY30365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LXU7"/>
    <dbReference type="STRING" id="796604.A0A2X0LXU7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021331">
        <property type="entry name" value="Hva1_TUDOR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11160">
        <property type="entry name" value="Hva1_TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hypervirulence associated protein TUDOR" evidence="2">
        <location>
            <begin position="10"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY30365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="221" mass="23745" checksum="761137C4FE7AF8F9" modified="2018-09-12" version="1">MVKAQELEKGDTVKWQWGSGEPKGKVEGVVEGDAKVTTNKGNEVTRKGNEENPAVKIKADSGNKAIKKASELSGVETGKSSGGKKGGNKKKDDDDEDEEAEEADGKEDTDDDDDDDDDEKESAEDEKAKSKTDEPASKFNAKSAPKSETNKPASKGKNGAATKSNTMDDDEEKSTVPSKRPQRSEAAKTGKKAEDTEDKAEDDEEEDPKQPLKKKGKAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LXX3</accession>
    <name>A0A2X0LXX3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C002g01176 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C002g01176</name>
        <name evidence="7" type="ORF">BQ5605_C002G01176</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY30718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LXX3"/>
    <dbReference type="STRING" id="796604.A0A2X0LXX3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052430">
        <property type="entry name" value="IVT-Associated"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804:SF3">
        <property type="entry name" value="PROTEIN BRE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="685"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="710"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="738"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="770"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="794"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="835"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="346"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="419"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="346"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="419"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="434"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="471"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY30718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1092" mass="121199" checksum="3A084DDA15FD8687" modified="2018-09-12" version="1">MVQQAGRTTGSPSRLGRWLGRQHAPNSRWLLVSVLKATIALTLTFALVFSRPFANLNPHAGSCLNSMVLAVVAAYPGKTVGGFVHNFIWSALGLFGGVVVFVILATLCEYPTRLQNRFGSGFVFALWVYLVALVRALGPKYISFFLYGVLFAFNGIYSPIELAKQSGRLAFESSWLLAYFQAYGYGLVISLAVNFFVYPTQSSAELNTLLIASLQHISSLAHLTCKAYSKEIEADEEQVRSMLVQTIRSDYLALASRLEETAYEVRLHSQFRLVDWQDMIAKVQGLQQALITSSSALDLIDELDPEGINVKRHLLARSESAATFKAFRRGIDLVIASIVDQLLGNDKKQQQRKHTGEEDVHGQEMRERWHMHSRANQEPTLPPPATQPRTGAAEPVAGAPLSRKETIEQLMSIGDKLRREVQRSEVRQQHASRESSVSNAPTTNDPTTPEEQAQAAADLRHTLSKRTTVSDPKRRTLSGDEEKGYDAGSEVGFLRAAWKRFAQVQADALISLIKDGSLGIEDVLRIEEGMPGLQMIVYDRYADRLPKAWTSSLVAETSLRRIRHAVPMSSFAGSSRGGKDSAPPEEVAISAALTKSYSILFGFGQLTDELCSLHSLVTTNRKKRIRPYIFYTLRQKLLAPWQRPNGMTLPEALATLKGDPYTAPKVTLTQRFVWFERWLRGDRSLYAFKVAIGASLYTVFILTPSLQTNLFLKYGMTSSLITVIVAISPTLGQTTWTWALQLAGTGVGALYGLIVLEIFHNAGGHVYNPYGLAAAIAVWAAFSSFIFYGSPQYYTASLLMMVGSGNVVILEYLYNENPVAMATLRQPYEAPPLRFAHLIGSMGISIGISAILQLFFWRSPARRQLRKEIATITSSLARYNTLLQTLINVVAPADDAPMPSPEALDQIADELVQQEIAIQSALLKLPTTFGYAKVEPTFGLPFKADVLLKIINSHQIILDRLREARTAVGTRGFNETVHKDFASALFPYRLHSQRLARVLFHLAATSLMCKTPLARDVPSSKPTWASFENDALVLSRRLSQLPRGEAELKRPGFLRYWFYLVSLGSVSSELESLEQYLGELFDDPHMISDGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LYN0</accession>
    <name>A0A2X0LYN0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01416 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01416</name>
        <name evidence="2" type="ORF">BQ5605_C002G01416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY32853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LYN0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY32853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="51" mass="5306" checksum="CA65C260496016B5" modified="2018-09-12" version="1">MHGQNLSAAMGCQGAILMLLVGMTIAFGRANAAADRDGTEVEGSSTFRYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-11-27" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M063</accession>
    <name>A0A2X0M063_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C019g08955 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C019g08955</name>
        <name evidence="1" type="ORF">BQ5605_C019G08955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY23602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M063"/>
    <dbReference type="STRING" id="796604.A0A2X0M063"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF8">
        <property type="entry name" value="NUCLEAR MRNA EXPORT PROTEIN THP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY23602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="466" mass="52046" checksum="F7B7A54210F6C187" modified="2018-09-12" version="1">MFTLDTYLGHVQRLYASAPTELVQLISFDGEAAIVQPLSQLLNSTPALRSTSYTSHVRSFFSDSRPFADLIAAYLLFCRDAPPPDEADDPTALNTSYSLLEDCYKCVQRRPRPRPLGGCAHVGVVLFPFHRQADKLFAQGDSAWFVPILRSLTSTLIQVALKFSTKAGTIMGDRKLIKAGEAARLLSRPMGVAASDRSKETPSKRSALFFLVNSTFKVYFAMHNLRLCDTILSNTSNAVGGSFSEERFYPKSDRVTFAYYRGRVWLYQRRLPLARNELRKALGLVEEQAWGNTRLILIYLIAASLPLGILPTVHLLREYDLDDQYEGLLLALTKGNYVQVLAELDRHRAWHLSKGNYLLLKEKLQVICWRNLVRTTRSSRLASLLIMTHGKPLPPSGPPTLSLNALVVTARIAFGDQSLDLDDVEGMCTSLMDQGYLKAYIMHSKALLVLQKSASFGFPPISSVHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M0J2</accession>
    <name>A0A2X0M0J2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="23">BQ5605_C003g02005 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">BQ5605_C003g02005</name>
        <name evidence="23" type="ORF">BQ5605_C003G02005</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY38347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0229">DNA integration</keyword>
    <keyword evidence="18" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="16" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="15" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="16" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="17" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="22">
        <location>
            <begin position="444"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="805"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="806"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="SGY38347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1414" mass="157528" checksum="DE40108EC8990CC0" modified="2018-09-12" version="1">MLSRLLKRCGVADSTTDAEYLALSHSGKEGIYLSQLLEELHVQPVAPAHIFTDNEAAAAVARDPVRVTGTRHIRLREHFVRDMVNRGDISLSHVGTSDMVADIFTKALGPKVFSTHCYALGLRTRHPRLGSASHSRGGGGDCLIRTTFVAAQGDSTEMPSATEIFTRLYRDVKARPVDTPVAAVATPQARHGCSRPCPNPSCRKMHWLRECPDTAWAAAYRARRTAEKKASQPVASPAAVDTLNSVSFTACLLATPSPFCKSAWLLDSGANRHMTNDRGLFSELRTVAGPRVGGVAGSLPSTGCGTICIQTSKGPITVSNVLLVPDLPCNLLSVFQLDQLGYRVSFASRCASIARPSGAVVATAQAIGNNLYALALGPTPCTPKALLAIPTKVSLLTLHRRLAHLPVAQIKNIVQKGLVTGVDWVYKDQELRDFYCNACLASKAHALPFARSKSIASGRLDLLHVDVARMPRPTFGGHRYMLVIIDDFSRKHWCILLALKSDVFPCLRDWILEVENATGNKVKTIRSDNGGEFTLGNFVDFCASKGIRRELTIPYTPQQNGCVERSNRTIKEGILALLYSSGADSRLWGEAALYYVHCKNLMPHAGIGDEIPDTRWHGFAPDISTLRAFGCRAWHHLPSAKRTDLDPKAVPLLFVGFDQHAKAFRLFEPSTRRIQLSRNVVFHESGIRGDIYNYLSLFKALAILIQEHFIRPHLWQLIKDEYKGKLFINQHCLTLIPADSPLINTELLRTHSALDGQLLVMSFRLRGDIKILEINNVYAPVDPKQQAKFFDKLLSHKTQKSHLRLRGGDLNDCPRPEVDRRNQSRRSHHWPILIGKLDSAYTDCIRYKHSITPSFTRPNPNCKRPNSFSLLDYFLLQQTHQRRLDQASTIYDYPKELSNHRPVLIVLALSDDPDATLPQLSLPTTSNQLHRINTTTFKTVEFQRMMEGWLEGASGEELVEELEVILKACRDRGGEMARRLHRERTERMEYLVGRVQDLEAIPEWGEAETAEWTRTSEELKRAVEERVCLLRIRAHVPEIASEERLSRPVHAKLAARNSDSKITALRLSNGELTHDIDVPRDLDRVDQLRDKFLAPIRAARTCDDPRSDPLFLRRLSESQINLLQRPITEDEVVAAIGTTHPGRSPGPSGVPYELYQTAPKAWAKKNADHAELLLYRPITLCKCSYKIFTKVYVARLNQILPNLLPPQQHQFVKDRQSADAALHLRLLIKELGAHRTEFPAATLLSLDQLSAYNLVEHDWIFAIFNALGAPATFLCVLRMLYSGDSTSARYIINGFLTAPVRLTCGLGQGDPVSLSVWDIVFQPFLDALHCQNIALNLSIPALHPYPQSRAITSLAFANDVVVAVAGLESLNLLNDLALDWRHAMNGRLNTAGQLAPRFSLSCSSNFIGLVSLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M0Q6</accession>
    <name>A0A2X0M0Q6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C018g08708 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C018g08708</name>
        <name evidence="2" type="ORF">BQ5605_C018G08708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY26191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M0Q6"/>
    <dbReference type="STRING" id="796604.A0A2X0M0Q6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013726">
        <property type="entry name" value="Mitofissin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28075">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28075:SF3">
        <property type="entry name" value="DUF1748-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08520">
        <property type="entry name" value="Mitofissin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016088393" evidence="1">
        <location>
            <begin position="29"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY26191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="83" mass="8861" checksum="FB6E1E8EC402BEC6" modified="2018-09-12" version="1">MVLGRLAHYTFDVVLLATVAAGVKRSTGFQVSTRGLPEGPVQQTAETVLGVGEKVFDYTAALSYSSGWFERELPTAASSLPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M191</accession>
    <name>A0A2X0M191_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C018g08657 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C018g08657</name>
        <name evidence="6" type="ORF">BQ5605_C018G08657</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY25699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M191"/>
    <dbReference type="STRING" id="796604.A0A2X0M191"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="275"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="350"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="466"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="556"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="737"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="350"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="364"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="582"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="600"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="746"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="801"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="827"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="837"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="869"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="885"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="896"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY25699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="908" mass="98221" checksum="984ABAEB6350DDAC" modified="2018-09-12" version="1">MAWQDTSTVYFRNNNSSNNNNQHHEPSASRTAFSSPPPPSSPSAASSSSQLSRSTGGGRKPLFNMPDPLHQNDDNVPLYDPRGLMVRTRKASTGASSQGTSERSREGSLVDQGSSSVMATSPPSMFVGRGFSPGRDDDGDVMMQDHQGEELGASSSRSVPLHPTTRTKASFNRLRVGSSGAPAPPSTTAEISSNQTSPLPGHSSEVAIPARARGIPISRSRASSTSTTTTTGTGPVSPAASWLSSFSPSGSANGPSTSFGMLRAGDEEGFVIGGYTLGRQLGQGAFGVVREATRVKGSSTGEPEKVAVKIIRHQLLGHAQSAGAFVQEPVSIVGEALRRSASGYRLPARDRRLSNFERERHRSTSSPVPSPDKQSAANQSAFASLQLNDSPKPTPEPEMEPKTSFIESLLAREIHLWQQLARHPNLLNLLTTTRTDDFTYIFMPICEGGTLLEYLNAGGVTAALRGDRNKPKSRSSIGPGFGDAQNEDTTPTRVGLLPRVVLPIFAQLVEGLYYLHVDARVLHRDIKLENILFDEKDQTWKIADFGLAESLLSAYPTLPEPPRPASPTKGGGLSTHGYGSITPGQSLASLSRANSVSRPDHHHHHHHHAHASDRSASLNHGAAAPLFDAIAEHLHPAGSLPYCSPEQMASPTPILSPSIDIWALGCVLYALLFGSLPFIDEYEPRLRSKIMKGIWEIPPSSPKLDEDVIEVLRGCLCFDPTQRWDVGRIRESRWLRAFYDPPPTPSRGRQSGRRSLLPLGKTDQESTSSSSRSPSAVRKATRSSSRSSATVKHLGISARTRSVERSNLEKEDRKMRWERGREERRQSQSQSQTQTQNGSVCSSRSASRGRETSVDTTGTSGAGARGRSRVRESSRNRTGSREGLRSQSRSLSRALGRVEERSARGQPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M2T7</accession>
    <name>A0A2X0M2T7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C002g01552 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C002g01552</name>
        <name evidence="7" type="ORF">BQ5605_C002G01552</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY33808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M2T7"/>
    <dbReference type="STRING" id="796604.A0A2X0M2T7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22212">
        <property type="entry name" value="NDFIP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019325">
        <property type="entry name" value="NEDD4/Bsd2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13396:SF5">
        <property type="entry name" value="NEDD4 FAMILY INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13396">
        <property type="entry name" value="NEDD4 FAMILY INTERACTING PROTEIN 1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10176">
        <property type="entry name" value="NEDD4_Bsd2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="511"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="81"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY33808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="552" mass="57953" checksum="169991F383A8B7EA" modified="2018-09-12" version="1">MASYLRLPFGSSASSSSAAGSGSASSAHRARTVPTPDFGAFDLEHDDEDGSDEDGDDHHEGRHMLSTSHLTATQAGLIRLGDDTTDPLTQHQRQHIGGDRSSTAATVNHHATSSSPTATSTITRIPGAYDFEPQPHHGGGGGGSAGTPLSPQPRLGRVVSHSGLGGMGMSANNPSGNDANNRDTRLLRNRFMPSALYARINRSDMDDSPEQDGLLFDQDEVDSEHRTSTTSPMASTYPPSRVPGIGSLHVPLPARAPQFGAPTPSSGAGGRIYGGGQANDGVFGNLSAKPDGYPRGSDYVGGDESGGDKDEILPSYTAAALDSTPPYWETTVVTPGGVLGPDDIHVDGLPVGNLFGFMWNLLVSMSFQFVGFLLTYLLHTTHAAKHGSRAGLGITMMQLGFYLKQQADHPELLMMQINGSMPNPMDVPMDDGAGTRWSWWGGVSTDAIDGLNETVAATATATSAAFGSIPTQIGNGISGALNASDPDGFPSLTGNVNAEDFVRMSTNANEWMAFIMVTIGAFLFVGGCLSYWRAVRWARAISQNRGPGMTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M2W1</accession>
    <name>A0A2X0M2W1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BQ5605_C002g01572 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C002g01572</name>
        <name evidence="12" type="ORF">BQ5605_C002G01572</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY33952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M2W1"/>
    <dbReference type="STRING" id="796604.A0A2X0M2W1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034490">
        <property type="term" value="P:basic amino acid transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.24:FF:000012">
        <property type="entry name" value="Sulfate transporter family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052706">
        <property type="entry name" value="Membrane-Transporter-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43310:SF4">
        <property type="entry name" value="AFR304WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43310">
        <property type="entry name" value="SULFATE TRANSPORTER YBAR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="526"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="563"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="605"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="635"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="739"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="772"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="825"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="11">
        <location>
            <begin position="896"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="1095"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="115"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="294"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="148"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="333"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY33952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1228" mass="131654" checksum="3FAC08CB7A52858F" modified="2018-09-12" version="1">MAPSVSSVGSSPPRLPDVALARRRSQSRTSSGSFRSSLGGKPIGPKYGAASSSALRRSDSSSTSASSVAVLSTNLSSLESSHGGAPSPLANTSAISIGDSALKFGSFSATREELRDGSARLASLSLSQPSPNLATASAPQPSFPLGSPSHSPFSAPQDQSYLATAVEPINAPAGPSHSSSSPNNNGHLKPSPSNLALARPSTLFQSQSTTSSIGDVGSPSSPLAVSSGLNGSPNSGGTDEITPTQSKVGTPSMGLGRSLTLSVRDGPSSGEATPRPLGTLGAEQAKLDASAAKLAKARRKEERKQLKLQILGDETGGTDSGESEVDNNALDADGERSSGSDESPDHSRPGTVNGFAANEQTPLLGRGRRPSHTASKPHSIKTDGGILATVLSALAHRAHSAIQRVRSVKVTQDGLKQGARDSVTALPAVILGVLMNILDGVSYGLIMFPTNLPRFADFGGIGVSMFFVSCVISQLVYSSGGSIFKGGNGSMMIEVVLIGLTCTQTQPFFHSIVGIIYKHLSDDKDVVATTMVAFALSSILTGFAFAMLGFLRLGRLSEFFPRHILVGCIGGVGAFLFITGLQVSARLEDSKGLSLELIQQYLDLEILPLWVIPLVLAVVLRLITARYQHPLIFPGYFLAIPLVFYIISLSARIPIANLRENGWVFELNGVDSEWYEFWTLFDFQKTDWSALIETIPTQLALVFFGLLHVPINVPALGISVGEDNVDTDRELVAHGISNVMAGLFGTVPNYLCYVNSVLFYKVGGTTRISGFLLAGGSTGVLLAGPGVIGYLPVCVVGALIFILGIDLVKEAVWDTYGRVSRLEYLTIWVIVFVMTVWDFVAGIGAGIILASVSFVVSSSQRRAIRTILTGAVARSTVRRHPKQSAFLKDVGRQTRVIKLQGFLFFGTISSCETTIRKILEAAEWCKNPIRFLVLDFSMASGVDFSAAEAFVRIQRLLDDKDVLLVLCGCASDSSVGIALRSVDLWVEGPESKVEVFENLNDALEFCENAYLRSLYSKNFEQPHRTNSSGGPPVLTSQIDMPKSELDSAIEELGKSPRASHLRYAAKEAMAKSDAPAHRSNLKQPLPLLMQSLKPFAADLNEDYCFRLVPYFKRIHVERGTVLWEQDSESDSFYLIESGILRANYVFVDRAHAIVESMVAGTVAGEMSFLSRSRRNATVTAERDSVLWKLDITHHEKMGQEQGWAFTRKLEACLLRIALEEQDVLMVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M3E5</accession>
    <name>A0A2X0M3E5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Casein kinase II subunit beta</fullName>
            <shortName evidence="3">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C001g00463</name>
        <name evidence="5" type="ORF">BQ5605_C001G00463</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2 3">Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY46703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M3E5"/>
    <dbReference type="STRING" id="796604.A0A2X0M3E5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1820.10:FF:000005">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000002">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF39">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01101">
        <property type="entry name" value="CK2_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="50"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="413"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00045899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY46703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="478" mass="53527" checksum="C0A900464E4DBEA8" modified="2018-09-12" version="1">MVGRWSKWGERTGATMLEEVQWASSRLAFTLTCALLRQRLAFAPGLLNRERPQRLHHPPGSTTAHRTASNPTASTSQWSFVRQDQQPYDRPRLRSLSRDDITVESYRTSARRTQPDPPSRTSRQDISGQGPIARLTPSLPRSRSLAHTRPTDPSYLLLLRFPFSLSLSLSLSLSLSPVFEPNGVSRLSRRHDHEHHHQPCHLPSVDDISNSSSASYTNSWISWFLASKGNEYFCEVDDEYIIDRFNLTGLNAEVQGYSAALELITDTSGPSSRTSASFHTTHPHLVLPTAEEDIEDEHREQLELAARHLYGLIHARFIITSRGLSKMIDKYKKGEFGRCPRVLCYGQALLPLGLSDVPYQNAVKLYCPRCEDLYSPKSTRHGAIDGAYFGSTFPHMLFMVYPGMIPSKSVPGAGAGGQGQGGPQGGLASGAASKVERIRPRIFGFKVHESAKLQRWQERVRDRQIARLEEIDQNGQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M3H1</accession>
    <name>A0A2X0M3H1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00480 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00480</name>
        <name evidence="2" type="ORF">BQ5605_C001G00480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY46897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M3H1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY46897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="481" mass="51880" checksum="BA8A7AA9AE947717" modified="2018-09-12" version="1">MHQSVAKITPAAARPPHYRHRVVRLTSTRCPGQLEAPAPISRSPPSSSTRAMTTKSPRSESASTSPPPLSKYLTSLLDHLETTNSRLSLSVAKPPHGLFKPGDTLHPVVALHKGSTEYTSLQLSLVVSTHALIYGKDRWQKGQMASAMLGNATTGAPITTIEQVPVYTVQVPWISPNNVGAAAPPASEKEQKRSLASKAGSDGPLHGGMYEIILPHPRPGELLPTMRRKDEGLSVPNRLGVSWALHLRGKKHGFLKLDDHLQIELPVGFPIVPPIPEDLPESDWVTAIASKDLLHKGTQGGGAITLHAKLSIQPPLRITTSITFHLTCSPSDPSTLSLFSPSPRLSLTLNQRAFTQPVLDKNLGQAMQWSGIVISASKEVPQFVEPDKGRGIWDWRGKVDVPEDCVTVEAKGLNVNYFITAQFTSDRIVDHSLSVTAPVFLPSFPGALTLEEVHGNGDMAQLGTSGSTTSNGQENLPRYTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M546</accession>
    <name>A0A2X0M546_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g03816 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g03816</name>
        <name evidence="1" type="ORF">BQ5605_C006G03816</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY53914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M546"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY53914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="262" mass="29176" checksum="FD267DF298F4C9E5" modified="2018-09-12" version="1">MDTSSPLTTGAHPTIPAEQLAALTSLLWGLTTATSATSSGTSRTAFPKHARLDGPKTFASWTRQLRLCLVDDIRSYVLDGIVPADWTPLHRSARDVVARELLANSIDSAKVLAVLDQIPTANLTAPKIYSTLKSRYAPDDATRTLELFSRLWSFRPMPGTVGKFDGWIMEFKAIAQEIINTKTTINNVLATLLLAIAHPSLESFKASFTNEQRFGLGTSEAREQSRAFHRAFHFALEPHWFRVQTERIKRCNSQAKKDYSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M593</accession>
    <name>A0A2X0M593_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g02283 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g02283</name>
        <name evidence="2" type="ORF">BQ5605_C003G02283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M593"/>
    <dbReference type="STRING" id="796604.A0A2X0M593"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY39833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1093" mass="122115" checksum="D69E6172F210DC72" modified="2018-09-12" version="1">MLCQATALARSAQVTKVRHCREKLGAQVARVRSPLYRSIMGYHAWRYIDTTRMETGPLLNRSKSKPEGERRLQRPTPPVLDSSSASDLDVDDHDLGSEDRASGMGCGTLDEEEDDVDGDDDDDDDDDDDDDGREDEFGEDECGEDEYGENEFGENEVDEGEPKPDPITAPHDDDFQDGGEDEDEGEGGSRQGQGTPANKEYHAPVRRRGLRASVREILPPLSPDHPETDNQRWKNTFSSLMRLQTLARELDFTVVNAVLLDYLNGWTRRDWHEIASSDSALVTRMRAVIHALQPRDSLTLSRVSRKPGQLTATVSVDLATMTLAEYGRHVEQFEGAANDDGSLLYNAASGLLASAVKEFREKGVLLPRYKLDSAYYQNVAQRYATDLLKWKDRGDYVLATYARHMFESRDIESALSPLDPDDEFRQPKGRKRLLDCLVTALSDVPFPWRSHRADLEALVAGIAKDQSDPDHEHLRAVMRACLQEACGSRDQRMRWGFGRDQASVTRLVGAKLSDFGPGGKLKNPIALLPVYHHLLLESGHGRGIVPTEGKRPFVNCSPGYLGAILTCPVSLVRTQLDWLNKLLAASVVNDVSEPAGNAASPTHFPVLRTLLGRGFDLIFTISKDEKTMDVKPEWARDAVAGVKALHHLCFGRPLAGSDPSTPTVPPELSEERLLESDAFAAFGPRLVDILFDTDRILDKDEIPAGSFTTNGHRVHLRVLNVSSVASTKRNKTWYNNPDVSIGSALDRTVAKARLWLRFQKKGKTDSRIVKHDYEHYVDGIKKPFRLSYARPGSAEKPSRIDELERKLRERAVAAAPIPFDPERQALIEREAVRFERVSWKRFRDVPIVGGRICIPSIHNPEARRAVLGRLQEHSNKKFGTQHAVATEDLIAVFRQRGDLFRDLWRAFEDSIFISIDLGHARPVTAVAQGLGAIAAKGNRKGARQRANKTHRINEALRANKLEWSPLAAKLGFPLRHTHDAISVSSTQQEANLTVMYQQAEQMAKVFGLECMDNNLQSPTLKGLATRFPRSHGFTSPGPNPSGVSYAHSCIQIIFRCLQALGLESMYFCTVSEYLTSKLCWHSDCWDTEGTRNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M5V2</accession>
    <name>A0A2X0M5V2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C003g02402 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C003g02402</name>
        <name evidence="4" type="ORF">BQ5605_C003G02402</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY40620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M5V2"/>
    <dbReference type="STRING" id="796604.A0A2X0M5V2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="376"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="22"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="247"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY40620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="420" mass="44425" checksum="0D657DED07BAE9CB" modified="2018-09-12" version="1">MEHASGSTPLTLKERIKALQDAANAETSTAASSTLGAAAPRAQAKLGTTSSSSSTTNNTDLAPNSLAPPARNDASTSTPKPTRSHAVSLVQSDPLDAIPSGSAPTRSPSRPNTPLASPSPSLGGGRRDVDTSTRTRAETIPTTRCAPPPRPFLSSRERSSSTILSSTSTTTSQPEPGRPAQSATEIPPRPSPSQTSHLRPTITDPLTSSATPRSNPTDSLEQLSTSTFPGTSSQTPTSPGAPRLPPRRTTTTSFLTSTLENRPVPPLPRPRSNASTPRSSDPVPSVPARREPPKPPPTTTRSATSVRSQSEASLATQRYAALFDLLIQRFGTVDIPTAAAPGKGPKWISKQNNGLPIQGERLDGRVVRSVWLKSRLEDKVMESIWTRCDPSSSGSLSKEEFIEGMFAIDEELRVRGRGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M6D6</accession>
    <name>A0A2X0M6D6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g04236 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g04236</name>
        <name evidence="2" type="ORF">BQ5605_C006G04236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY57191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M6D6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY57191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="68" mass="8153" checksum="56A123F6AD7DFF79" modified="2018-09-12" version="1">MRTEIAGMESDLQHKNQASRNKRDGLKIYSRETIDKKVKERNRPTRLFLYLFILKGGWEETKIERLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M6V8</accession>
    <name>A0A2X0M6V8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BQ5605_C001g00187 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C001g00187</name>
        <name evidence="12" type="ORF">BQ5605_C001G00187</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the WD repeat TUP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY44657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M6V8"/>
    <dbReference type="STRING" id="796604.A0A2X0M6V8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000503">
        <property type="entry name" value="Glucose repression regulatory protein TUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013890">
        <property type="entry name" value="Tscrpt_rep_Tup1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08581">
        <property type="entry name" value="Tup_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Transcriptional repressor Tup1 N-terminal" evidence="11">
        <location>
            <begin position="83"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="411"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="453"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="512"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="547"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="609"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="651"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="161"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="276"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY44657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="687" mass="72233" checksum="DD6A4D3E96A1ABE4" modified="2018-09-12" version="1">MSSNNLNANGDGRQGVGGGGPLHASHLGVGGPGPGAGDRVGGAGGGGVGGSTGLPPPPLASSMGGGAGAGGGAGATVVYAPSRLNDLLDFVRSEFDQATGEMGMLRAAREEYEAMIQLHANELNAMRSMSYDLERKHHDDKRVLQEENMRLQEETIRLRQQLDQRPPPGSSSLPLGGLPQSSASSRPVLPSIMAGGGVGGPPGSSSGGRPGSSGFPPSEYADRDRYGPPGGGSQVQGLRDRPIDRDAEHIKRSRDEDERYGGAMTPIGAKGKGYSSKPSPNVSNMSPYPQQPGSRPSSTAPNGGPSRDHAASPRPHPGSEMGGGPKENEAFDPDTTGFKKEGSDWLTVYNPNVKRVLDVGLVHTLVHDSVVCCVRFSPDGKVLATGCNRNTTLYDTKTGAKLSILNDDASNSKQDNYIRSACFSPDGRFLATGSEDCIVRIWNLAQKRVAKIFSGHKSEIYSLAFSPDARRLVSGSGDRSAKMWDMDSGTCLFTLQIDDVTIAENGPVDAGVTSVVLSPDGHYIAAGSLDTVVRLWDAHTGKLLDKLKSHKDSVYSVAFSPDGKYLVSGSLDKTLKIWDMNTFKALNNNQPGLIAQGGEGGKTACVTTLVGHKDYVLSVDTTPDGLWIVSGSKDRGVQFWDVKTFKAQFMLQGAKNSVISVAVSPVGGFFSTGSGDHSAKIWTYSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M8K8</accession>
    <name>A0A2X0M8K8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00887 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00887</name>
        <name evidence="2" type="ORF">BQ5605_C001G00887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY50473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M8K8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
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        <location>
            <begin position="464"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="538"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="582"/>
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        </location>
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            <begin position="664"/>
            <end position="690"/>
        </location>
    </feature>
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        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
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        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
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        </location>
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            <begin position="498"/>
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        </location>
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            <begin position="613"/>
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        </location>
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            <begin position="632"/>
            <end position="641"/>
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            <begin position="664"/>
            <end position="675"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SGY50473.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="973" mass="102422" checksum="431EE83211BD54FB" modified="2018-09-12" version="1">MAKQTLQARREMPQTLTLHPLAATSPAFSAKDPGAQSTSSPSLAVPTSAGSSSDGIHRSIKDAWGSRDRSSTSTNFTPPILSPAYSESRGSTYEVPLTPFSAVPTNFSRHHPQFQFLNSPDEVDGDHSDDLGGTDRGLPISASSTFVIDGASTDSLPRPCSFGDLVMSGHGSTSSFDSSPTGDTTSATLSKPFLLFGVTDDTDVLVVPPLRYSPDVSRQRVPSSNDSLGDTETSSAFSPSTSLASVRIARLIQRETFATPGLDLSSDQLEGGGATQATSTGLVGYPASPVTPVLMETEWISRSIPRVAGDEPSPRPSPSPRTMAMRRNDVPALEPSRPLSEVFLSDLSEADASVRMRTILGPKTRIISPAPWDDPDGVAPGVQDEPAPSAKFRKSANTRRTEPTKPTSPNGPPSPAKENLGFKARLGNRSKSFSLLTGKKLPAHEDTFESDAALNALMPTSSPMALGSKAAPRINTGSTNNSTGLSSPLSPALSVSSYGSNRTPIASSPESAALSPNDSERSSILTLAVPVASACVPQSAHADESSFAPTSSSSDLRDEQSAGCVSTSALGERDPYYVAALPDGYTSLSPRSPMGNDAPILPTGPGKNYRLISLDEARQREEDRKTAVAQRGQANASSSSGPRPDEPAAKQDAYDYSAERLSASTNGSTICSPRTNIPPPATPGTAAKTLKNRRSGFLKRMMGVIEKTEPIPRIPSLPQTSPTSASFPQQVESSHSVHSSLNESPSVIGPASPTSMLKSSFLPRVSSGAPATRVAFSSMPVPDPEHRLRNGQGANGAASAPSLSLRPVSMAFSAGLPSELMAEIEAAEMEEAKLSALSADTVMRNTPALRSPHAPSFVSDTTYTSSAFETAPTSPDVYTPLTSVFAVPPSAAPTSLKIVSPSRGRPWEVERAELEETIRLLRAQLYDQECECPECGHEFRQVLTAPSTPMSPSVVDRPRFHGHAAFGSARVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M909</accession>
    <name>A0A2X0M909_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C098g13109 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C098g13109</name>
        <name evidence="3" type="ORF">BQ5605_C098G13109</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000002">
        <property type="protein sequence ID" value="SGY11510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1109"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1007"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="497"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY11510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1887" mass="207035" checksum="BD3880B0CEAF8EF4" modified="2018-09-12" version="1">MVVTAWIGKKARSFYWIVFCRLPTAQQPALETQPRRDIRRCRGQHEQAMPDPPGAQAPPPDNPLGGNRASDDESLNTLTREPVTGGTANPPAWSTEATQARLDCEKVMQNTFRVLGIVPSGKSTRRLMVLMHDASTPPSQAPLLARAAQRAVRNDAAPASNVIRVIMDGPGSPRGPVQIALRKHFGLAETPFMFARPEGVVLDPEVEKLFSKCVKLNPIVTKATKRFPIARHMYELVFESDQACLEAAAAGPFSHHGKEMVTELPSASPLNHVVQVRFTLPSSSSATPASVLRQSLDDALTLSFGRAGRTQGYTLMQLQRGLAVDPNGDPMAMTEDGFHCAYLRLHADLFQGSTETQKAALNAALPQEIEILGAKYGLRHEFETHYCAVCDRAGHQWGACRKPVSTPATAAPVPGASTSTSTTGFRVAGKNGKHGGPAALNSRASGTNMIQLGPRANPAGAATGNKDDANDDDGGGESVASTEPEGGDTGKETLTRATTGPTKETQTTTAAPVSTPTSPSPSASAPASPLSGGTSESSATSTTSIASTSPRRLRSSSAPGNRRVTRAGSAMILGASGGDGSGGNSSGVNQVKIIRYLKTLRPAPAAILLQEHHLGYNASREGFESAWPGACIRFTPHVLTLIPDGSPLAGHLLSSTPVVFAGAPRLDGRILRSVFRLEELDVEIINMYAPVQEDDRRDFFGLLHFNAPRPKTLRILAGDLNDCPDVSVDRVSITDRAWTPVSHWQTLLSKIAFKALDTVRHVHSCTPAFTRPHYRGRGEERKICSWSRIDYILVQCSWANRLLSASTLFDAPCSDHRPVVATFALPTSNADAEPPLSLPSTSDFISRLNPTVFDDQDFVASIPGVVDEVYRRLEGTAPLGDVYDAALRAVAVAGHARYRSTRADMRRLRAESQSVMEALEARGEHMNEAERDAYAFAKSRLDQLAVKEAQWLRIRAHVPSVDSREGQSASIRTRLNRRSRQTSIVSLEDVDGTETVDMQEALGIASRHAQSLFTPDPARGDPTNPRRSLLDPIRAAKCYDDDRSDPTFGRRLPRQARVALDEPFTLLEVEAALKKTDSGRSPGPSGIPYELFKALPTYFAPKLLDLFNSIWEGGKMTASLAEGLVRLLPKNKPGANLKSLGAYRPITLRETTYKVLSKVLVARLNGVLGELLPPAQHGFMPSRRSADAGSHLTLLLEKLKSLGTEVFPEGALLSLDQQSAYDRVDHAWIFDVFEAFGFGERFISLLRALYDPETLGVRYLINGFPTELVRLLCGLGQGDPLSCPVWNITFQPFLDALVRRGIALDLQKVWPGGPRAQLTHLAFADDAVVVVESPAGLSKLETLSQTWYEATNGKTNTDKTLVLPLGPNWLRDETAQALPTVQEGRASSGAAMPSFAMAKARAARDRTLSPSGRVFYANAHITSTVLHVLSFDIPPQWFIQAAETALTDFVWGGPRRNTVAREFVFQAREDGGLGLISIGDIVHSVALRFWDAVAGSDEAIWAPLARESWRSLVAATRDFSPWGFFSSTARVEKLYRDSARWGAVVAAARVTLPTIKSELLTLPELLSLPPRLPSLYAEGAKHAYDDADAVAKFAQIADLYWRDEGKGWALVGHRRGFWQHSKEPALQHEHVWSRVGQLLKAKALLPKTALRPARIPLKEAPRPRCFNFFGLTRPFTIRKLRRFVNVVRFPGREDRVKRFRDGTSQSDRKRFWRWLHDRFASAVEQDTHWRLMYDVTPTRKRQHTQGHASSPTCLFCGNDAAVIETVSHYFFECAYSTSFWGGVLRILFDKLGIEDTDVDPSTFTPEQLTMGLPLLRGRGRTTSRWMWVRLACAIGFQRLHLLRWRVHQRFELDKVVAPPSLPSALRAFERDFLSRAGFVPGARDWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MAA7</accession>
    <name>A0A2X0MAA7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g04163 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">BQ5605_C137g13410 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g04163</name>
        <name evidence="3" type="synonym">BQ5605_C137g13410</name>
        <name evidence="2" type="ORF">BQ5605_C006G04163</name>
        <name evidence="3" type="ORF">BQ5605_C137G13410</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY56730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000053">
        <property type="protein sequence ID" value="SGY88818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MAA7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY56730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY88818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="50" mass="5404" checksum="ABBB2D66F7EACFDC" modified="2018-09-12" version="1">MAKSRSTSLIVASNFRDARGGVRASEARGTRYVSKRAEDGSKDSSEVLQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MC95</accession>
    <name>A0A2X0MC95_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C013g07134 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C013g07134</name>
        <name evidence="1" type="ORF">BQ5605_C013G07134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY14862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MC95"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY14862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="294" mass="32703" checksum="ACC5E089EAF17DAC" modified="2018-09-12" version="1">MYGIKRLGDAEYVLGIQLERSDDGSITLSQERYLQDVLERFDLALAKPASTPMQKNLLLELDQSTPSDQERTRYLQAIGSLMYAALGTRPDLAYAVSYLARFAKEPGPTHWTAIKHVLRYIRGTVSYGLRYTPTPGPLYGYSDSNWGACVRTSKSTMGYAYFLAGATISWCSKRSSRVADSTTDAEYIALSQSSKEAIHLQQLLEELGIPNSGPTLIYGDNQGANSLTRNPTSFSGTRHVRIREHFVREMVKKGEIKVEYIATADMVSDILTKALDPKLFVRHCESLGLRMPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MCD1</accession>
    <name>A0A2X0MCD1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C008g05216</name>
        <name evidence="9" type="ORF">BQ5605_C008G05216</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC6 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MCD1"/>
    <dbReference type="STRING" id="796604.A0A2X0MCD1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008504">
        <property type="entry name" value="Emc6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029008">
        <property type="entry name" value="EMC6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07019">
        <property type="entry name" value="EMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY79753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="143" mass="15746" checksum="C4ABC0FC7500512C" modified="2018-09-12" version="1">MIPHFRALASRVKPSPPFSRLIITRPALAALSTTPTSVDEAYYVPNLISNNNSLYYVKSTSISGATAGVLGLTNTFGFLFYLVTSTLIGSLFLLTKGTAEGKGYFPGDRVSAWRTVVLSGLLEHVFPYILFWTLFYALVHIYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MCX5</accession>
    <name>A0A2X0MCX5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C004g02668 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C004g02668</name>
        <name evidence="2" type="ORF">BQ5605_C004G02668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY66385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MCX5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY66385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="128" mass="14064" checksum="5CD6A330465F4B42" modified="2018-09-12" version="1">MISAQRLRKHNTKYSKETKSIHLTFIAETACMSLVAGLGFEHSCNEIRTVACFIGPGAALISGESGSYVIVISSGGFPCLTTHAIASWYRCVMSRGLFLNVEPKVIERPIGFGAKPLMPWVVVRRRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MDQ7</accession>
    <name>A0A2X0MDQ7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C009g05544 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C009g05544</name>
        <name evidence="2" type="ORF">BQ5605_C009G05544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY82090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MDQ7"/>
    <dbReference type="STRING" id="796604.A0A2X0MDQ7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="679"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="681"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY82090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="869" mass="97179" checksum="574BDE5EDCFB83A2" modified="2018-09-12" version="1">MAGNTTSRPCPFSWCKGASVSKATFYRHHARQPNGPRATEEAAILEVPRQPSMLLAPPGPQSQLFQPPRPTPSWFATRSPQKYTQSAERIVSRKAFVGSSMGAQLNDSALSNDTQAYGSVSSNISHTDAPNAPSLPYESEEFSMNISPELPQIPEGDYDFERASWTGGSMDSFEGHALESDQDVLRHTQLFEMTSALETTSPALQPLDNYSSSSLPFDDDDPLVVEELWGADQRLDANGVYNTPTTSRLSSSQERAVAEEEVRQEIELAKALPYYDVDTLYDFSFRHMYNMTRQASKIWEVLGSWPSLQKVRARVFALTVVDLGLKPVRIPCCVKTCVAFTGPREALTRCPVCNSPKLDQNGHPQNTFLYLSPDVYLNICLRDRVYASLMRYRSDFERNRDPQEVVDLFDGDRYREKLDQNISWTNPPIAGASQPTVSTINVKYYENDVDVAFGLFTDGIQLFNKTQSECWPIIMINYNLPPEIRYKKKHLMTVGIIPGPKGPKDIDSFLHPLYEDARASARNRHMVFDGVTETMVRQRWFIHVIGGDGPALSKMLGFKGPTAKWPCRVCLIQGVPCAAAHNHNYYPLKMPLDSSHANRSDLTALDLPMRSEVTIREAASEKNPTFGLSKLSSAAHLPGFSLHQDGPSDFMHAVFENVARKLFNMWHGDLAAQKSKDYKTQAPQAQRGRSAQGKVTSAASAEATTSAAAVDEALGTDLPDWVIPNKIWEVIGQEITNGAKTIPSLFARKMPNIHLQTGAMTAEDWSNWILYVGPCVLHDRLPAKYFAHFLALRRWVKDCMAMTINKEDVAKNGALRRDIASWCTEFESHLTLICLVYLGFRLYYSGKSAHLINLPHSVHAVLHIADFIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MEW8</accession>
    <name>A0A2X0MEW8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C015g07972 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C015g07972</name>
        <name evidence="2" type="ORF">BQ5605_C015G07972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY18082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MEW8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY18082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="790" mass="87383" checksum="71E659408809B5E0" modified="2018-09-12" version="1">MVTQCNSPSPTGSTPSTSPTSQFHRRALSTSTRVFFPSMTNPSMRSPPTTPPRRGRGNGSVSFRYVNESPTNAALLRKTRQRKSTSRVFEKLGQWFERNGSTRPSVLLTLLTCLIITFGLFSLAETPRTDITNELSGWVRIASKVHPNHWAPGYSDTFRYKSQNHANRPTKGEVALAEAAPDKDVSNPDDESEVPDPAPIHGAGRRPSDGPQRVEIPAKPTTEDKGLPQNVHPIHEDEVPSNNTEETNEKDGAKEQATTNQTNRHDGGDRDGDHHDHDHDLHREEQNPDTEADTDLSESKDAKDDDQEHVVDEDNPDHLEQELQAAVAAAALAAAAGSNPVVKVVTLKPKFEDDRKFLFPAWIGEQETKAQLHLYQLGLLAVALNRTLVLPQVHKSRFSACYSSPFSLYYSTDTLDSFNIPWITHADFLALAHRELQNQKGESSAKTGQLVGMNRGNPVPADAAIMPLNRLCLAKLGLELEAYEPKAFFRHSRSAKIDIELAQRMIADLQAPDPNTGTTADVIVIQYNLRHEILTPGLVRPYQAPGSKPVREYQYFQYSPHWTLLGQQMAQALSPFLAVHWRSETVGVDALRPCGMSLIAWVKQMVAKRPEVKTAYFAMDYPIEIWLDGTGPGTQFSAHSGSMTRRITLAHHNAFQGFVEDWQREFGDTVKMTSFKGVLGSIELDTDLRALLGVGAKQKQADFDRLDAAIVGIVDKNILARAEVFLAGYPSNGASALVKFCAKNSQFTDQIIDGRIRAIKKQGSSSMAGSEGQLWNAVDRFATTSSRQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MFW9</accession>
    <name>A0A2X0MFW9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C035g11386 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C035g11386</name>
        <name evidence="4" type="ORF">BQ5605_C035G11386</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000064">
        <property type="protein sequence ID" value="SGY97156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MFW9"/>
    <dbReference type="STRING" id="796604.A0A2X0MFW9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00513">
        <property type="entry name" value="Ribosomal_L32_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001515">
        <property type="entry name" value="Ribosomal_eL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_eL32_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L32 AND DNA-DIRECTED RNA POLYMERASE II, SUBUNIT N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01655">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="Ribosomal protein L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY97156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="130" mass="14919" checksum="7FFAC89AA40F9CE6" modified="2018-09-12" version="1">MAATTIPRIKKRTKPFIRHQSDRYAGVKAAWRKPKGIDNRVRRRFKGQLPMPKIGYGSNKKTRHVMPNGYRRFLVNNTRELELLLMHNGSYAAEIAHGVSSRKRVEIVEKARVLGVKLTNGNARVRTEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHS4</accession>
    <name>A0A2X0MHS4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="11 12">3.2.1.106</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">BQ5605_C019g08879</name>
        <name evidence="17" type="ORF">BQ5605_C019G08879</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(4)-(alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:55988"/>
            <dbReference type="Rhea" id="RHEA-COMP:12806"/>
            <dbReference type="Rhea" id="RHEA-COMP:14355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:59082"/>
            <dbReference type="ChEBI" id="CHEBI:132537"/>
            <dbReference type="EC" id="3.2.1.106"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="11 12"/>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY22991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHS4"/>
    <dbReference type="STRING" id="796604.A0A2X0MHS4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.110">
        <property type="entry name" value="Glycosyl hydrolase family 63, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031631">
        <property type="entry name" value="Glyco_hydro_63N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038518">
        <property type="entry name" value="Glyco_hydro_63N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF11">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16923">
        <property type="entry name" value="Glyco_hydro_63N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015903839" description="Mannosyl-oligosaccharide glucosidase" evidence="14">
        <location>
            <begin position="22"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 N-terminal" evidence="16">
        <location>
            <begin position="72"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="15">
        <location>
            <begin position="342"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="15">
        <location>
            <begin position="819"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="SGY22991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="859" mass="97134" checksum="140C095ABC2F5657" modified="2018-09-12" version="1">MRGVRWILTVAILLAAATTNAELTKEGESSDQVRPRLSARDEVEGTRQKQPLLSLWRFDAEADHPPPSIHQSLLWGTYRPGLYFGVRPRIPASLMHGIMWFGLQDYPSAQNARHRCSQDDGMVYTYTEHDARTAAKQFIKDQMNNVELTTEFLKVPAGDKGGNWAVRISGKPLDDLKPSRISLLNYFGNDASLGFLDLEKPDPEGIVGPITIRGETQELGSFKITVVNGESNEAVSEGKHAADFGDELERTHFLGLNVPPGEVWKARAEVMPVMMENAVRIFKPYGERNDHPDPAYVFLLPDQVRSGSNLITLQKTYEGTWSVDIFYDSDASPSKLDSAALSLGLSAASRSFIDRFEATFPLSKEFSASQRAFAQHITANLIGGVGYFYGSSIIDRQFKNEWDLDTDDDDLLSTIKKPELTPPRELLTATPSRSFFPRGFYWDEGFHLLSIGIWDNELSLEIVKSWVSLIDEDGWIGREQILGEEARVAVPEEFQAQYPYIANPPTLVIAIRASIERAHKAAAGEANVGADFVDQGSALGKASTQSSAVAREFLASIYPKLRLHYEWFRSTQRGQIREYDREARSSTEAYRWRGRTKDHVLASGLDDYPRARPPHVGELHLDLLSWMGEFARMMEELAEFLDEEDDINDYQTHHRDVLNNIEDLHWSEKDQMYCDASVDENDESYHVCHKGYLSLFPLLLAQIPVSSPKLGATLDLLRDPDHLWSPYGIRSLAKSHELYGKDENYWRGPIWIQMNYMVLSALHKTYAKQPGPYQTRAGQIYAELRNNVIDNVYNVSPVSERHPTAVLSLTPVRSSHQPQEYVRTGAVWEQYDTETGKGQRSHPFTGWSCLVTLIMTEQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHU2</accession>
    <name>A0A2X0MHU2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C009g05452 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C009g05452</name>
        <name evidence="2" type="ORF">BQ5605_C009G05452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY81078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHU2"/>
    <dbReference type="STRING" id="796604.A0A2X0MHU2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY81078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="172" mass="18716" checksum="5E5E06F5E34411B0" modified="2018-09-12" version="1">MTSPHLPDPHLPGAPSHRSISAHLPTTSSPASRRSDGSTKASTTSSTGSLKGWPTESPIPSRSPSPPKPLAYSFAAQRPWVLRTWMFPSSSEDYTGFRGHEIKWPPLEDFFLGPDPAPGITWLSGEPVWEPQGRLVKAPLRQDSDLYDPAENPDFVVLSRQSFGANPEFAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHU4</accession>
    <name>A0A2X0MHU4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">Uracil-DNA glycosylase</fullName>
            <shortName evidence="7">UDG</shortName>
            <ecNumber evidence="7 9">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C009g05631</name>
        <name evidence="7" type="synonym">UNG1</name>
        <name evidence="12" type="ORF">BQ5605_C009G05631</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7 9">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="7 9"/>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY83342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHU4"/>
    <dbReference type="STRING" id="796604.A0A2X0MHU4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097510">
        <property type="term" value="P:base-excision repair, AP site formation via deaminated base removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.470.10:FF:000007">
        <property type="entry name" value="Uracil-DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003588">
        <property type="entry name" value="PRK05254.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003589">
        <property type="entry name" value="PRK05254.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003592">
        <property type="entry name" value="PRK05254.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264:SF0">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00987">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="11">
        <location>
            <begin position="174"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="48"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY83342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="362" mass="38935" checksum="FAC8FB482496EA57" modified="2018-09-12" version="1">MTGAEVPTGKRASASSKAQPATKKARTSGQERKITDFVTVLTGGAAVSTSASSSTNANAPEAEINNASSSKSIEPNKGKAVATKGEPELEPGTFSPTAFLASLPSIGPSPTIHDLLSLECATLDPSWLTLLKAEITKDYFLDLKRFLWKEGVQGPESATAKVFPRARDIYSWSRHCPLDKVKIVVIGQDPYHNEGQAHGLAFSVRPGVAVPPSLRNMYKELSNEYPDFVPPKTGDLTPWARSGVLLLNTSLTVQAHKANSHAGKGWESFTDKVVHLVDKFGGSDGAGKLGKGVVFFAWGAWAAKRVAKLDTTKHLVLRSAHPSPLSVHRGFLNNGHFKQANEWLEKKYGPDGIIDWSSVCPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MI65</accession>
    <name>A0A2X0MI65_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C030g10819 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C030g10819</name>
        <name evidence="2" type="ORF">BQ5605_C030G10819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000069">
        <property type="protein sequence ID" value="SGZ08837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MI65"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016093488" evidence="1">
        <location>
            <begin position="18"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ08837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="105" mass="11565" checksum="349CCC1F7BCB68CF" modified="2018-09-12" version="1">MRFLPILLVAAVVGIQASSVGLCPNLDKRCDQGYNSTDACIEGRYGLYVGDVPGSVCDWAQNATTCWNKCLTLKVHWCTDQNMQPEDMGNQTLCCENECCAKRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJ57</accession>
    <name>A0A2X0MJ57_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C010g05884 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C010g05884</name>
        <name evidence="7" type="ORF">BQ5605_C010G05884</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJ57"/>
    <dbReference type="STRING" id="796604.A0A2X0MJ57"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013934">
        <property type="entry name" value="Utp13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF15">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08625">
        <property type="entry name" value="Utp13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="138"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="180"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="225"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="403"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="449"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="510"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="564"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="606"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="648"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 13 C-terminal" evidence="6">
        <location>
            <begin position="702"/>
            <end position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY13528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="930" mass="102017" checksum="13DCC286191EDD87" modified="2018-09-12" version="1">MERGTRAHISSPSHSFKAVRAYEPIHTGGKVVLSGDGSWLVSTLDDQALVSDIATGERIQLLKGVSFILFPYMACIIPTEPTSRLNLSLYQDSSAVTTLAITPTPASPNAGGYLLTASRSSALHLYSLPSLTLHRTIAKAHSAPIITSAADPSGRLFATGSADGIVKVWDAENAHCTHVLHGHGGLISALFFDVGADGRARLVSGADDCKIRVWDLHTRECVHVLDGHTSVVTGLQVTKDGKNLISGGRDQVVNLWDLERGVLRKTMPVFETLEAVGLVQLPDQVAVWTAGDKGVIRLWDLRNGEEVNKEQRGNGKGKVHEVVQVIHNATTSTLTAVYVDQNIITRSLPTLEVLRQIVGYNDEVIDVAYLAPSRPEDESHLAVATNSDLIRVYDLARFNTSLLEGHNDVVLCLARSTDGSLLASGSKDKTARVWRPKSSGKGWACVASAEGHVESIGAVAVSKKERNFLVTASQDRTVKIWDLASALGAEEEGEVKDDAVTVALKSLTTQKIHDKDINSLDISPNDRLLVSGSQDRTAKLFSITYTAKTKSSPPTAALSLLGTLKGHKRGVWSVKFSPVDQCVATASGDRTIRLWSLADFTCVKTFEGHTNSVLRIDFLTRGMQLASCASDGLVKVWNVKDEQCVSTLDNHDEKVWALTVAKDEKHLVSGGADSVITVWQDVTEEEEKAKIEEHEDQVLKAQDFENYLSIRDYSNAILLSLSMDQPKRLLKLLTEVRLAASEDLKSYTGSSQVDQVLQSLGDVDLRQLLLYVKDWNTNARTSEVAQGVLHAILKLHCAEKVLECLDPQKPKKDLDQDVNFGVADDEDEDEFVNDEKRKERRRELAKKRRTEIKAGDLLQALIPYTERHLSRADKMVRESYIVEHLLGQMISYELEADAVNVANGLQAMEVDLDLDRNDAVAAWADEDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJH4</accession>
    <name>A0A2X0MJH4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Calnexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C020g09059</name>
        <name evidence="13" type="ORF">BQ5605_C020G09059</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the calreticulin family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000082">
        <property type="protein sequence ID" value="SGZ16696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJH4"/>
    <dbReference type="STRING" id="796604.A0A2X0MJH4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.250.10:FF:000001">
        <property type="entry name" value="Calnexin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000011">
        <property type="entry name" value="Probable calnexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.250.10">
        <property type="entry name" value="Calreticulin/calnexin, P domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001580">
        <property type="entry name" value="Calret/calnex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018124">
        <property type="entry name" value="Calret/calnex_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009033">
        <property type="entry name" value="Calreticulin/calnexin_P_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073:SF1">
        <property type="entry name" value="CALNEXIN 14D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073">
        <property type="entry name" value="CALRETICULIN AND CALNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00262">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00626">
        <property type="entry name" value="CALRETICULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63887">
        <property type="entry name" value="P-domain of calnexin/calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00803">
        <property type="entry name" value="CALRETICULIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00804">
        <property type="entry name" value="CALRETICULIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015802128" description="Calnexin" evidence="10">
        <location>
            <begin position="20"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="486"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="223"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="293"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="527"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="126"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601580-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGZ16696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="576" mass="63311" checksum="244A4A6BF551A6AE" modified="2018-09-12" version="1">MRFTTTWLVLATSASSVLASGPVTFEPSTISGHFVEQFTSSWTQRWSPSKATKQNTDKDAEVFSYVGEWKVEAPTVYPGISGDEGLVMKSKAAHHGISALFDKPLDPKGKTLVVQYEVKLQNGLDCGGAYLKLLSDSAQGIQAEEFSDATPYTIMFGPDKCGSTSKVHFIFRHKNPVTGEIEEKHLTAPPTPIISRTTNLYTLIVRPDQSVEIKINGESSKNATLIDDFSPSVNPPKEIDDESDVKPEDWVDSPKISDPSATKPDDWDEDAPETIEDADATKPDDWYEDEAAQIPDPDAEQPEEWSTEDDGDWDAPKIPNPKCDTASGCGPWKRPMIANPAYKGKWFAPLIDNPLYKGPWSPRKIANPAYFEDKTPSDFTPMSGIGFELWTMTDDILFDNIYIGDSEALAEQFAAETFKVKVPIETAAEETEAPKEDKEDVDPLTGERFVRPILTKDPIGFGQFHLQRFMDKAVEDPVGAFKTMPLVGACIVAAFAGLVGLLTVVFASILPSSSTVQETKKAVKSKAEDLKKKTDAVTEDVKEKADEAAQVIEDKKAEAKEGVRTRVRKSAAAEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJJ5</accession>
    <name>A0A2X0MJJ5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C036g11522 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C036g11522</name>
        <name evidence="1" type="ORF">BQ5605_C036G11522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000063">
        <property type="protein sequence ID" value="SGY95862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJJ5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY95862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="52" mass="5918" checksum="3282E4520A8A7074" modified="2018-09-12" version="1">MVSFRLGRGSWPPRVQMQRFFQCRCSIYDSAAAYQDSWPGAPAQDLSAHPDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJK1</accession>
    <name>A0A2X0MJK1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C020g09089 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C020g09089</name>
        <name evidence="6" type="ORF">BQ5605_C020G09089</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000082">
        <property type="protein sequence ID" value="SGZ17034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJK1"/>
    <dbReference type="STRING" id="796604.A0A2X0MJK1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF49">
        <property type="entry name" value="MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="4">
        <location>
            <begin position="75"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="5">
        <location>
            <begin position="232"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="31"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGZ17034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="577" mass="62284" checksum="949DBDE5476FD09E" modified="2018-09-12" version="1">MTISTTTRSLLPRSPRCLPLLCTAARRTLLPSSPASPLRHPPRRSLATTSPRRSTPTSADPLPLQVTALPNGVRVATDPAPGHFVAAGIYVDAGSRYESDLTRGSGHMVDRLGFKSTSNRTYEQMAKEIEHLGGQFLSSSSRETIMYQATTYTHSLDSVVSLLSDTVLNPLITPEELDQQRDAALWEIGEIKTKPEMILPEVLHEVAFQHNTLGNPLLCPEDRLRTMATSTLKDFLKMWYKPERMVLAAAGVEHDRMLDLADKYFGHLEKGVGVGSTITPATSSSLPFVPSAASTSIPTSASTASSSLFRHLSTSATSSASLASSSASPSPLDPTGFDYLSTAPAKYTGGELYLDNPDLEFTHIYIAYEGLSIHDPDIYALATLQVLLGGGGSFSAGGPGKGMYSRLYTSVLNQHYAVDFCAAFHHCYLDSGLFGLSIAVNPTWIASAPWVLANELDAITRPTQGGIDHGDVQRARNQLKSSLMMALESRMVQVEDLGRQVQVHGKKTPMQEMVALINQVSLNDIYRVAGRVLRPKKSSIVGDRKRSGKPTIVVQGQLNGLPDIPGTLARKGLNGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MM42</accession>
    <name>A0A2X0MM42_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C028g10539</name>
        <name evidence="11" type="ORF">BQ5605_C028G10539</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000080">
        <property type="protein sequence ID" value="SGZ12961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MM42"/>
    <dbReference type="STRING" id="796604.A0A2X0MM42"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04652">
        <property type="entry name" value="LbH_eIF2B_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051960">
        <property type="entry name" value="eIF2B_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056818">
        <property type="entry name" value="GlmU/GlgC-like_hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24894">
        <property type="entry name" value="Hexapep_GlmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-1-phosphate adenylyltransferase/Bifunctional protein GlmU-like C-terminal hexapeptide" evidence="10">
        <location>
            <begin position="577"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="37"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGZ12961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="689" mass="73945" checksum="ECBBA323BD4EED4E" modified="2018-09-12" version="1">MLPNSLIPTALPKAQFRAVVTCGYGSDLYPLIEPLATFTDDEPDESPNAPLSPQHHHHHQRHDSQAGANATGVMGGSSSGTGAGAGTMTGLGSNTAGTSAATSARTKKPGQVKALLPVVGKKMVDWTLDRVEEAGVFGACGTRLSACGSGQRTRADTASRTADVLVLSPSSLASPIAHHLRARRTAPSTSNLPSGTPSTRIELEEVPDAVARQGSVAVLKWATEKGLIKSDILLVPCDLLLVPTPMTTISLASLIDRHRTDDNLMTTLFYERAAGAVAEARKDGPSEILTIYDSKTSTLLDIREMDEFDDDEIPLRTSLLEMSVQNVGIPLFLRSTDAYFAFRLVTYNRFPSPTLSTTLLPCQVYVFSSLIFPLLTSLNNARRLSHMESLREFAGWVARLSWRNSGKDAVGYRDVRSVQREDGLAMGRSTTQAPLSLSHPSKFPFANSPQSLSGPQTGANTPALVSRSSWLRTSISNGPNNGEWDHGLLSKAAIGGAGAGGRKNDRAATGGCKLVIWKSHDGWCGRGNTVAGYVELNRSALKLLPAQPPATNTPQGVFISPDSWLHSSVHANLGEKAGVKRSIIGRGCFVGRLTKLTNCVLMDGVHIGENCKLDNCVVSTNVQIRDRAQLKDCEIGQDYIVEADGQCHKTETFRVETILDLTSFRFASSCFPLPFSASIKNEQLVVELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MM97</accession>
    <name>A0A2X0MM97_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C108g13202 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C108g13202</name>
        <name evidence="4" type="ORF">BQ5605_C108G13202</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000071">
        <property type="protein sequence ID" value="SGZ10365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MM97"/>
    <dbReference type="STRING" id="796604.A0A2X0MM97"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030011">
        <property type="term" value="P:maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF205">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="279"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="287"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ10365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="710" mass="77164" checksum="5A9DBC873F8E9A6B" modified="2018-09-12" version="1">MARDIARGGSCSPTACFVYRSQEDEGKASRGSINMGVAQIVTSASDKLKFEVNNKLGKVSHHSSSRAAPSRVMRWVDALKQNVAYAKELSNTVSQTPSRAPSIAPSVGGGSLETRISTLDPDGAGMDSQGELCTTATDRFSMMKRNSHAGGVDPTARRDFARGRGGSCERNVVFDEVRKAIVGSLGTLESALDEYIDVVNLRERFFENMKELAAQHAAIERNCTRRLETAPDESARCKRFGANLLSSPPMSPIAGTPIDTNPGSKALQVDTQSLATATAANAAAMSSPRNARGRSTTMHTLKPQELEDLVDSALAGEAGEDDSALSDDSDEFFEAIESGQIPVDNDDDDKSAPTAPEAEALTTAHHHRQSAAVSLWHSQRLHCKDLTKISFPVFFNEPTSMLQRMAEDVEFSDVLDHAAAQEDATRRIAFVAAFAMSNYSSTIGRIAKPFNPMLGETFEFADLSKNACIAQSATWDYYGDVDAKSKFMGKVSRSAQLVLLMPTKDTSGVGAELPASTTPGLVEEHYSWTKVTTSLTFKPRGWRSSGAAEVKGKVMDKDGKEFWDLAGKWSSQLVARRVAPAQVILRPTQLCPTNKDGDVSPEYIRLWKNSEKPNPPLPFNLTPWAVQLNDDNAKLRRWLPPTDCAFVLTNTRSRMASSSGPTISNLNWRTINAPRAASVSKVNVHRTQRVGSDEVRTKTRGVVLGARQDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MN67</accession>
    <name>A0A2X0MN67_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">BQ5605_C015g08024 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C015g08024</name>
        <name evidence="14" type="ORF">BQ5605_C015G08024</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY18265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MN67"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090114">
        <property type="term" value="P:COPII-coated vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032527">
        <property type="term" value="P:protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025305">
        <property type="entry name" value="UCH_repeat_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF2">
        <property type="entry name" value="PROTEIN SEC13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13446">
        <property type="entry name" value="RPT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="8"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="53"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="13">
        <location>
            <begin position="1282"/>
            <end position="1912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="405"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="496"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1403"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1452"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1486"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1546"/>
            <end position="1566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="405"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="496"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1403"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1416"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1454"/>
            <end position="1465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGY18265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1925" mass="211769" checksum="C38576F42AF02D99" modified="2018-09-12" version="1">MTASQTIETGHVDSIHDAQLDYYGRRLATGSSDRTIRLFEVEGDDRYRLVDTLRGHDGPIHALAWAHPSFGSILASCSFDGKVFVWKENDGPQKGWSKVKEHLLHTASVNAIAWAPHELGPVLACASSDGKVSVLTFNDNGTWDASLFPAHALGVTSISWAPAVGVGALTSVDGQQDGGPLAIQQVKRFATGGCDALVKVWVWEEETKSWSPDPIQPILEGHVDWVRDVAWAPSVGVGRAYLASAGLYFVLCTYQDKTVYIWTQDSPRATWNRVALEPTPTAPTQAGAGAGAGGEGKFGEVVWRVSWSVSGNVLAVSSDGKVSLWKENLKGKFEEVSTPSVMAPDGGCRFQENLHAAQVELRRWQHEATPLPHPPLHPMHPTSSSARAIPTPADLFNPVPTSSFFGSDGVSSSSSPSSSSSPHFHRASMNPTDTPRVPPPRLPAWTNGTRPSAVYDDALHSTTNRVRSGSSSSTTSTTASTANVTGAVGGITSMSGVETSSFRKPSISPKQTLPSLPPSWSSISPQVARAPPPPLLPPSSHGAAVPAKEVGGEEMVPSNQQSRPASLGWALPPQPSTRADATGWEVDPNAPLTSSTLDHQQIEFAPPPFAIPHRTRTTRARYRFSNIAGLGWTAPKILEKPVRGGVVGGIWQHGVWDFKVVNTPENYPPMGELPQRPVKEPVVPTTMTSPLSPTSETTESLDAMQVDGEATKRSAAVAAEVSMQQAPPQHKTISRAELDQARPHPYLYYVPRQHAWALFAPFEQTDAHRSFVDDGQVRLWISSYETAEVLLRRLEPPLPPPFEPFDTTKLPLPAREVYDAARRVCLEPEPEYVTKIDEPKSGRSILFSEQELYPCVIPMLVLHELLRTRSESPSPGDSAEDANLNAIQTLWRSLDNLLFKAEQRPLSINGKAFARCLPWDELTRAIYVAILGFRLTPEETLCPPNLVDSTDEGRVNRNRLLRCWLELGLWIEHVRKLEDQVRIRRVATRVELSSGVDAMKNVLGPDTLARVPASSAWAIAGRSAMTAGFDGPVNLSHQLAQAYHFLGVTPDLADSVLEEVYKEQVGRCSAYTADFLETIQEINHDRRSDVLEMLIATERSIGRVSISDLRNAYKELGLEFDHSRSVTDDEIAFRFGQRREQVTDPERKKVLKEAMKQIADQRDSELLKVMLLSANDEEDRPAMSLEKAYKLLEATPEMSDEILSMVYDVRIADAPSQVDVMTQALATIGQAIGSDAIRVKLGGDTGECSQGEDQIPWILSADLPHTDPPAALIPQPAPDMPVGLTNIANTCYLNSLLQYFFTIRELREAVLRFQPTPTTDVSAFNRVGGRLVTKAEVERSKKFVVLLQTLFNQLIHSASTSITPETELAYLALVPSKDEAEVLTTTSSADDLIVLDDPARTSGSPIATTSMLPPTSDDSNLKSPSSSILGKRRNSHLDSDIKGSLALDQVRLESSQAQSPNQSSSDGASPPADLVVDLEAVSALNREKSGASLSRSSSKTVVGELLGSSDEQRKMKRGKSVDGSIFSHADEMKVDDDDDDVIIVEPPTGTSMARSPTLPPRPRRPSKAVTKLEDQVSNYMSFGRQNDVTECMDNVMFQIECALNPDGTPDEPSGSATTNDASTSVLRRTLYGKMRQHLEFTDPSVPEPIRIREEPFFSLLVDVAEEGHTVYDGLDTVFDDSIVTIEGHEARRRMRLVDVPPVLQIQLQRVQYDRVAQRIFKSNAHLDFGETLSLDRYLEVEEGDVEAAQRQAWTQSKRDEIELARTKLMALKSTKTGTSYGTCIKEAFVHLSTLKDELGDLLTTEFAHDSLEEAAWIDQQIVELETRINDSRKAIEECWATQAKTVYELAAVFIHRGTALSGHYFIYQRDSKNRDRWLKYNDSVITDVSGEDKVHLRSRDDTNAYFLVYCRRDRLDSIESIAREF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNL1</accession>
    <name>A0A2X0MNL1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g02357 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g02357</name>
        <name evidence="2" type="ORF">BQ5605_C003G02357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY40349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MNL1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY40349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="190" mass="21724" checksum="1159929C59772BE0" modified="2018-09-12" version="1">MSHRPLCHKATKIVADALRAQGPLTTQSLYDVVHATHPSSLPARPLPNRYRMGHTRPPASIMEMRRQQREQVDLPREKGDTDGTWSMAYLKKKVLAGMLEKGQVVKMTKIKWDKLRGVEPTTTTTTEERAKATSVKEATKKLQNYEKKAAETHFWILKDTFAKEGIFLPEQREEPSRPTTSRGKANTRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPC3</accession>
    <name>A0A2X0MPC3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C021g09408 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C021g09408</name>
        <name evidence="3" type="ORF">BQ5605_C021G09408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000083">
        <property type="protein sequence ID" value="SGZ21713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MPC3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1285"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="697"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1759"/>
            <end position="1779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="698"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1759"/>
            <end position="1774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ21713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1903" mass="210540" checksum="A399D3F23D6BF180" modified="2018-09-12" version="1">MQTGDPGSAPGARAPPPPASAPTSLPIAGTKETQATQVAGRTATYAAATNSSVVSNETPAQQQDRLARLQALPGILAAIQAVPGNRADRFVQAIFATPDFPSTVATALKFSALNATRNIINPFANALEVSLSHKSTGRASATDKGELVACVRTLLSPNTPICFDTGVPLSGDLEAFMPRITGLQHSSTFRTGVLHHRITVGFVSAEARDAALASAPMLVWNSANARFAKAHPFHRNMLEMRINVGVVRPPSKEQIVAAFQSIVQQLSTKGHSCQLVQVLRVIHVDTAKAYAHTVGDFSAFIHFDDASLFQHPTTTLKEILPSRMDLPTRGLDVTAVRHDYEKEAPCARCHFAGHVERCPLMQAANRKEAEDLARHAVMRGAGMVGGGEQTGVGRAATTTTNNIRPTANNNNTSEVVAPSRALGTDQLESRNRFAGLEVEGGQEDDIEEEVAGKEGEEKEQVKEGDEDTGAKADDEDSDSDGNAGAGIDKAGGDGKDDDKDDDEDDDKDEQDDSSEGSERRGDDVMKDGAEEEDEGMETEVEEEVEQEQGVQDDSIMIIDDGQTTITTVSRESTPRSPSWPPLSPETLAKSLREGAEWDRANAEAAARVQAENEAIINAQLDAQEPLVRHQFAEWGQEDGQLRFINIRGTGSRSNKKMKRSQTRVLNRVKGRAGKEVAGQGKRVTRSMSAAAAMQVEGAKAKAEKGKGVEEEKRWSDHEPEDDILPEFPLFEDNITAKSTWNVRRCMGIPEKRRDIYTYLSTFKASAILLQEHFIKPELWQCIKDEYEGKAFISKHCLTLIPADSPLIDAEILRTHSALDGRILVTSFRLRGDIRILEINNLYAPVDTKQRLTFFDKLHFHRTQSTHLRLLGGDLNDCPLPAIDRRNQGRHGHHWPILIGKLDSPYTDCIRFKHPLTPSFTRPNIVRKRPKSFSRLDYFLLQRTHQKRLVQASTIYDHPKDLSDHRPVSIVLVLSDERGDAAQPNNSLPTTSNQLHRINAATFKTAAFQGMLEGWLEGASGEEPVGELEVVLGNCEKEGRELARREHRERVERMAVLVGRVQDLEALPVMGDEETAEWTRTTEELRRAVNERARQLRIRAHVPEIATEERLSRPVHAKLAARSSDSKITALRLPNGELTHDIDVALDHTQAHFQRLYNLEPRDRDHVERLRDDFLAPIRAARTCDDPSSDPLFLRRLSEAHIELLQQPITEDEVVAAIATTHPGRSPGPSGVPYELYHTAPRAWAKALSRAFNAMTERGSLSPKQGQGLVRLLFKHHKIGADRAELSSYRPITLRECDYKLFTKVYVARLNHVLPDLLPPQQHGFVKGRRSADASFHLRLLIEELGARGTEFLTRRSCLLTNRRLTTSMLYSGDSTTARYIINGFLTPPVRLTCGLGQGDPASSSVWDVVFQPFLDALHRRGIALNLSLPTIHPYPQSRAITSLAFADDVVVAVAGSESLTLLDDLALDWRLATNGRLNTDKTVVLPIGCRWEAGDRPLVVKAEGESLEWIGLSFDPTGNTELANVNLVARLEAVLDSARDRGLTHHTRAFYVNRYAIPKILHILSADIPPLEVVKELDRILVDFVRGGKRRSCYGKDVVFTPRFKGGTCARGDCTSPSRPDFDLATDAWPCDYTPIRTDLHPRWQAVLKVPSTHNAQVKPRTLTLANLLALPIKLHTLHYLPGAPAVSRSPYDADYAAFANYAKVADLFRRELYPGGGFHLWTPRRMWSSATANTINGAPTTRAHCGMVPTCDQSIKVHTNSSTGGGSTNQRASPSPPQIRARRFKGFWKGVNSKALTAREREVWFKLGVLCDALGLDTIDNTHYTAVQRMFGLPKLKASLRDQEGAGRTIEIFTGLVLEMISSGRWGMQKWGTRMEGVVRRRIILEERLKLRAGGAWGRRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-03-27" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPZ0</accession>
    <name>A0A2X0MPZ0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C025g09985 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C025g09985</name>
        <name evidence="2" type="ORF">BQ5605_C025G09985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000087">
        <property type="protein sequence ID" value="SGZ26881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MPZ0"/>
    <dbReference type="STRING" id="796604.A0A2X0MPZ0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="15"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ26881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="107" mass="11616" checksum="7C451AE44F2B89FD" modified="2018-09-12" version="1">MSLPFNAPKAQSGKIILVANVLAKDGKGDEVQAALAKVRAAAEASAEKDTHTYRTTRSEEDPHKFLVFEEYTLPNGIVDHVAGDTFQALAAAGIIADLDIKYFHEFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPZ8</accession>
    <name>A0A2X0MPZ8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C001g00192 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C001g00192</name>
        <name evidence="5" type="ORF">BQ5605_C001G00192</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY44698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MPZ8"/>
    <dbReference type="STRING" id="796604.A0A2X0MPZ8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="32"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="498"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY44698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="604" mass="66061" checksum="8D44F86FB3717C13" modified="2018-09-12" version="1">MIHTSPHPLVELPVCSVWDKVWSNPAGLVDSEVAVIDGPSGRTHTRGDLKKKSQQLAYGYRQLGLTPGQVVCIFSPNSFYYHMIVLAAQCAGCVLSGANAAYTPQEMAHQLSDSSTELLMCHPSNLDVALKATKAVGWSEHKQKERIVLAVMADEAGPAGNSESWIMYALHPLSNFSTLIFSSTFLCTAYKSISDLVNSKHELTPFRVEDPKSTVAYLGYSSGTSGKAKGVRTSHYNMTSVLSILKPFVVTKDDVHLAVLPLNHIYGLTKLLHWPLITGSKVVVMPKFELEPFCAIVQKYKCSVCMLVPPIALLLAREPIVDSYDFSSMRLIVSGAAPLSGELAEEVSKRLGAAVCQAYGLTETSPTTHYCPIETPTPGSIGPLLPMMRGRIVDPETGKDVEPGEQGEMWVQGPNVMVRSRSKSCGNERANPDFTALFLQLGYLNRPEANAETLVEDAHGRWLKTGDIAWVDQKGYYFITDRLKELIKYKGFQVAPAELEGTCLECPYVADVAVIGVWDDDQASELPRAYVVLSAEGKKQTDGAKAVREWVDQRVSAHKKLRGGVKIVDMVPKSPSGKLLRRILREEAKAEAAQAKAAKQKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQ26</accession>
    <name>A0A2X0MQ26_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Iron-sulfur cluster biogenesis chaperone, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C001g00222</name>
        <name evidence="8" type="ORF">BQ5605_C001G00222</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Required for the assembly of iron-sulfur (Fe/S) clusters in mitochondria. Assisted by the DnaJ-like co-chaperone jac1 and the nucleotide exchange factor mge1, it mediates ATP-dependent Fe-S cluster transfer from the scaffold proteins isu1/isu2 to grx5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY44948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQ26"/>
    <dbReference type="STRING" id="796604.A0A2X0MQ26"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11733">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000014">
        <property type="entry name" value="Chaperone protein DnaK HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000020">
        <property type="entry name" value="Chaperone protein HscA homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000004">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003520">
        <property type="entry name" value="PRK05183.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="638"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="547"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="655"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00059314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00070638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY44948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="665" mass="71564" checksum="2EF92C0869B64B77" modified="2018-09-12" version="1">MLSAARLTTMRSARSPLASAVRSPAVMQARFNSGGVNGPVIGIDLGTTNSCVALMEGKTPRVLENAEGGRTTPSVVAFTKDGERLVGLPAKRQAVVNFENTFFATKRLIGRKFTDAEVQKDLDNVPFKIIKHTNGDAWLEARGQKYSPSQIGAFVVGKMKETAEGYLGKPVKHAVVTVPAYFNDSQRQATKDAGTIAGLDVLRVINEPTAAALAYGLDRNDSRQIAVYDLGGGTFDVSILEMQKGVFEVKSTNGNTHLGGEDFDITLVNYLVEEFKKESGLDLSKDRMAIQRIREAAEKAKIELSSTTQTDVNLPYITADASGPKHINLKLSRSQFEQLVSPLIAKTVDPCKKAISDAGVKVSEINEVILVGGMSRMPRVIDTVKAVFGRDPSKGVNPDEAVAVGASIQGGVLAGSVTDVLLLDVTPLSLGIETLGGVFTRLINRNTTIPTKKSQTFSTAADGQTAVEIKVFQGERELVRDNKILGNFQLVGIPPAPKGIPQIEVTFDIDADGIVNVSAKDKATNKDQSITIAASSGLSDKEIESMIEQAEQHAEADKARRELIEAANSADSVAAETDKALKEHKEQVDAEEAKKVEALIAELRELAIKSQGDDAVTPQQLKDKISETQQASLSLFQKVYERKQQQDGQAAPSEEPSKPEEPKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQE4</accession>
    <name>A0A2X0MQE4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Telomerase reverse transcriptase</fullName>
            <ecNumber evidence="2 13">2.7.7.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Telomerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">BQ5605_C025g09993</name>
        <name evidence="17" type="ORF">BQ5605_C025G09993</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Chromosome</location>
            <location evidence="13">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the reverse transcriptase family. Telomerase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="2 13"/>
    <dbReference type="EMBL" id="FQNC01000087">
        <property type="protein sequence ID" value="SGZ26907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MQE4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000333">
        <property type="term" value="C:telomerase catalytic core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003720">
        <property type="term" value="F:telomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01648">
        <property type="entry name" value="TERT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021891">
        <property type="entry name" value="Telomerase_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003545">
        <property type="entry name" value="Telomerase_RT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049139">
        <property type="entry name" value="TERT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066:SF0">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12009">
        <property type="entry name" value="Telomerase_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21399">
        <property type="entry name" value="TERT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01365">
        <property type="entry name" value="TELOMERASERT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00975">
        <property type="entry name" value="Telomerase_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="9 13" id="KW-0779">Telomere</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1181"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="16">
        <location>
            <begin position="773"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="272"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="321"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="563"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="331"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="SGZ26907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1321" mass="149317" checksum="CCBE6B70CF3C7FA1" modified="2018-09-12" version="1">MSSRFPHPLPARPASPTSSAPPPTTLAASHAQARGPEPNRPPHRLLDVFYRTHRALANLLPLELILRAEDTSSYITFVKQTIVATCTVDERDDEGWRALQQLKHEAGDVVTVGMQEVLAQVHTRIFAQHAKKLAKNRQAPGTWTSSTPKNVLCLGHRPVCRPGMTISLTSLCALQIDITTSRPHDLTTSRSTCVPPMPSYGTEPPRFTWCRSTSTDWIRSGQETQPKIGTNAMIHLLASPDLAVFSLLPNGCLLQCSGTPLAELITLASRAAKGDVAKPSRKRKRSRAKSKFQSEPIDIDGPVPMDVDEVKATGFVTGPLPAAPDFVEPNRPSTAPMSRTASSMDVDDHNFDSNLATLKRKQNEGLARPVKRKKLPTLNSPSEIVIPRMRLYHARPNKDPKARLVYGLSNKRKRGLPYQGRLSSRREAEPFLPLDILTRLPAMFPPAAQQTKADAGQLLGGARHLAKYIFPRQFGLHNVFTYPKPRLNVEVVSDHHDREIEIKKLGTVKTPERVKPTLPMLQRMMLLHSRCNYRKMLDRYCPKKVTKEANLSQAERAVLLNLMSQPDTQSPHVEPSAKDHEEDEEDETPMAHGASQARARVRAKPRFTEYMCSTYEVICYVTAIVRDTIPRDFWGSKSNENLVLKHAGEFLRLRRFETMSLHTLLQGLCVADCDWLLPLSATRPRNRFQRAPSVEMAKRREVLMEFLYWFFDGFIVDLVRGDDLALQKTAFCVTDSATHDKKAIYFRHDDWSSICGPSLSSIRQTMFDSIPDEKAHVLLADRQLGFSFLRLLPKATGFRPIVNLARKPLITGPFGRKELGKTINKVLQASFDVLTFEKNRKPQLVGSLVGSPMDILERLKAYKIKMSKNGTQPLPTLYFVKVDVQGAYDSVKQEKLLSIVDKVLTESDYAVQKYAQVILQSRKPFRSWRRLACPEDDQDQFEHLAKKIAARTLEGVLSDQVVYQSITRPEVMKLLREHITANLVKFGTHFYKQKDGIPQGSVLSSLLCSLFYGDMEHKVLKFTNDPNSVGSGSENSTGFHQLSFGQYPIVQLLLRYVDDFLFITTQKPLAARFLRVMDRGIPEYGCKISPEKRLTNFDIALRPEEVVPPWRDPAFPWCGHTINTGNLDVRADTTRSSESDITNKLTVQRHSKPGESFLHSMMVQVKVRSYLLYLDTSHNTLYTVLLNIYQSMAIVAIKFVAYVREWKQARTRMRKDFFLGAVRGTVGYGWSLIRFRCGGKKAKKFGAEFGVGKNVVLWLSTQAFIHILSYQLNVWSWVVNELEADLILLPLTHEERSLVRSVATDEGNVFIEKTLQRTRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MR37</accession>
    <name>A0A2X0MR37_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C001g00552 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C001g00552</name>
        <name evidence="7" type="ORF">BQ5605_C001G00552</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY47636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MR37"/>
    <dbReference type="STRING" id="796604.A0A2X0MR37"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007854">
        <property type="entry name" value="Fip1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051187">
        <property type="entry name" value="Pre-mRNA_3'-end_processing_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13484">
        <property type="entry name" value="FIP1-LIKE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13484:SF0">
        <property type="entry name" value="PRE-MRNA 3'-END-PROCESSING FACTOR FIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05182">
        <property type="entry name" value="Fip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-mRNA polyadenylation factor Fip1" evidence="6">
        <location>
            <begin position="181"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="422"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="511"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="452"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="480"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="541"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="584"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="614"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="637"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="652"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="664"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="708"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="755"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="816"/>
            <end position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY47636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="833" mass="88493" checksum="8D042461BE04B1A5" modified="2018-09-12" version="1">MDFDEDDAFLYGDGDELVINHTPQKEAAPAPAPHTGASAQNGGDDEGEMQQDEEDSDEDIELILDGDPVPPPPPSRRPNAPVPVLPPVSPTKPLTAPPTTTDYSPLDRPGTNTPNPNLNPPAPAPTPATEDDAPHPPPTTAKLEPTLIPRGSLYPLQPTMPPPSLDVDLIPQDDQGHDLFDIELDALPEKPWTRPGANMADYFNYGMNEAAWKNYAQKQKKMRQEVQNDASNPFAIFATSDLPTATSSLHPEQKILLVASLMGIQPGMPGPPPPQAMMHMMSMMAAASGAQGGQGVNPAATAQAFMQQQQQQMMAQQGLGGYSNQGQGPTQGGMDIYGGGGGPNTQIGGQARMMMNGGNGANMPQGMQGNGEMGIGGMGGMGGIGMGMGMGMEGGGFGMPQGAQGQGQGQGQVETFENEGAADLNDPNATQQNVTEENGEANEGGDADYSTMMQQQYQMQQQMQQQQMHQMQQMQQQHMMGGGRGRGGMGVNLRGGRGAFAGRGGRGGGGMMMLSGGGANGLQPGLPQGAIPTGPRNVPTALPPNVPTGPRNAGPPPRGPRGGVHATYHDKDRQAGQQEMSGLDYGGASGGSGGVSTSHSTGGAEGRTPLNERGGGDRRKRNYSEESGRSRSRSRSIDYSRGGSTTTTTTGAGTGYEAGGRARGVTERERERDSPRDSPRDSGSERRGSRKATGRSSRYLAEEEEEGNDSRTDRDKGDRERRDRDHDVGAEEDARSAGFKIKGSQAAAVVEEDGAGDRSSREVSASREAEGHRRRSTRYDDVDHREASSRRSGTRRSRRYSEEEDADDRDSTRKRKYEDEHHEPRVTRSRASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MR67</accession>
    <name>A0A2X0MR67_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C041g11939</name>
        <name evidence="11" type="ORF">BQ5605_C041G11939</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="FQNC01000119">
        <property type="protein sequence ID" value="SGZ33170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MR67"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000007">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="10">
        <location>
            <begin position="327"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="18"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGZ33170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1015" mass="113485" checksum="CFC8F834F342E453" modified="2018-09-12" version="1">MSGEVGCRTEVVRGKLRNRKGARTGIGPAVGELARAPRQLRASKSPPQGGGLAGARPIPTARGRASGCARRPRRLCRAESGLFTRPGPRMVAAIRTFQETGDSTVFAGLSSNSKDDNDPSYAPHPFPPLPVSLAGAHGTLLASALVDSGSPQTFLSEELVQRLGLERRALEQHSKYTLAMQNQVPTVFTCTHFVRVPLELANGLWAAGPTYTEVAPLGKDLAIILGGNFIYRHKMELGLFPQPHLTCKANPIHAIDLLALLSQPCAAARVAAIAPVSDDKEQLRLAALDHRLRAEFADRFPADIPPVHLYQSPKYCEAWYLLLQEHLAAGRLRPSRSAYSSPSFIIPKKGCDVDPTIAPRWVNDYRELNKHTIKDRTPLPLPDNILSTCSNAQFWAKIDMTNSFFQTKMAEEDIHKTAVSTPWGLYKWTVMPMGLCNAPATHQRRVNEALQGLLGTICFVYLDNITIFADTLEEHEARVRQVLDALRRAELYCSPTKTNLATAECSFLGHIINRAGVHADPKKIQRIEDWSLPKTGKELRGFLGLVQYLRKFIPGLAEHTTTLTPLTRQGLSSIATLWTPNEARHFKAIKAIVTSLDCLRPPDHSANAAPFWVMTDASNQGIGGVLLCLSRCVTSNFLVWSPLVLRSETYHCLSRCVTSNFLVWSPLVLRSETYHCLSRRDNITLLQGQEWKVARPIAYWSRQYIPAERNYPTHEQELLAIVEALKEWRIDLLGGHFHILTDHSTLEHFQTQCTVLSRRQARWLDTLAEFDYNLRYLPGEDNIVADAMSRYSFTDPLPTLVAAVSHVKLSDAVKQQILDAYKTDPFCQQAMSNIGSVTSDFKIVDALLYLRGRLIIPSLAPLRESILHDAHDAQGHLGDMKTYRTVQQAYFWPNMSRDVKHYVQQCDSCQRTKARTTRIAGKLHSLPVPTRPMADIAIDFVGPLPANKGFDRVLTITDRLSGYIRLLPARKADTAAEVAARFHEGERHEIALEPHWFRVQTERIKRCNSQAKKDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MRH7</accession>
    <name>A0A2X0MRH7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C001g00682 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C001g00682</name>
        <name evidence="5" type="ORF">BQ5605_C001G00682</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY48694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MRH7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MRQ7</accession>
    <name>A0A2X0MRQ7_9BASI</name>
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        <recommendedName>
            <fullName evidence="9">Eukaryotic translation initiation factor 2 subunit gamma</fullName>
            <ecNumber evidence="2">3.6.5.3</ecNumber>
        </recommendedName>
    </protein>
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        <name evidence="12" type="primary">BQ5605_C018g08704</name>
        <name evidence="12" type="ORF">BQ5605_C018G08704</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
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            <begin position="78"/>
            <end position="286"/>
        </location>
    </feature>
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            <begin position="1"/>
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            <begin position="1"/>
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        </source>
    </evidence>
    <sequence length="509" mass="54999" checksum="34C35BACB97CB46F" modified="2018-09-12" version="1">MAASPSPLQQSHLNPDHSDHDSGSESGDDAGVTTTGGATQDKPTYGVTEALARLSLMPEVQVDVSKLHPLSPEVISKQATINIGTIGHVAHGKSQTVKAISGVHTVRFKNELERNITIKLGYANAKIYKCKNPKCERPGSYKSYSSEKEDNPPCEVRGCGGTMELLRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAANEPCPQPQTSEHLAAIEIMKLKHILVLQNKVDLIREQQADEHHQSILTFVKGTVADSAPIVPISAQLRYNIEALVEYIVTKIPVPVRDFTTSPKLIVIRSFDVNKPGAEVQDLKGGVAGGSLLKGVLKLGQEIEVRPGVVSKDAEGKINCKPIRSKIVTLLAEKNELKFAVPGGLIGVGTLIDPQLTRGDRLVGQVLGSKGSLPSIYTEIEINYFLLRRLLGVKTDDKKQTKVQKLAKNEILMVNIGSTSEGGRVVSVKADLAKILLNTPAATEIGEKVALSRRIDKHWRLIGWGSVGQGTKYELPEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MSM6</accession>
    <name>A0A2X0MSM6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C052g12572 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C052g12572</name>
        <name evidence="1" type="ORF">BQ5605_C052G12572</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000099">
        <property type="protein sequence ID" value="SGZ29942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MSM6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ29942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="69" mass="7536" checksum="0866B4CED4989F43" modified="2018-09-12" version="1">MRVGGRKERFEGVAQDYLRGLICCSVDCRNDTDTAGAPHHVTNASPPLARQAELCCRSNIMQSHALAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-05-29" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MST0</accession>
    <name>A0A2X0MST0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01167 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01167</name>
        <name evidence="2" type="ORF">BQ5605_C002G01167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY30589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MST0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042332">
        <property type="entry name" value="Hsk3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013183">
        <property type="entry name" value="Hsk3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28289">
        <property type="entry name" value="DASH COMPLEX SUBUNIT HSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28289:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT HSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08227">
        <property type="entry name" value="DASH_Hsk3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY30589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="84" mass="9076" checksum="9D34231A91C8887E" modified="2018-09-12" version="1">MSSLKSQLSEIKQGQIQNLSQQLATLAQQTAKLEHLTVATAEQASYLRLLGAYHAAWFMSAARIMTSEDDASQAPPTQTPTAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MT13</accession>
    <name>A0A2X0MT13_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C045g12215</name>
        <name evidence="14" type="ORF">BQ5605_C045G12215</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="FQNC01000115">
        <property type="protein sequence ID" value="SGZ31618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000007">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="12">
        <location>
            <begin position="594"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="13">
        <location>
            <begin position="1136"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="11">
        <location>
            <begin position="1448"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGZ31618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1500" mass="168385" checksum="F357EF33523D8066" modified="2018-09-12" version="1">MPTPTAPSHSPTYKPNDPPQLHSTSMEALREYFMRLDFYNRRIARTPITSDYDKIEGAGMGLQVFALKTWFTQGLSKHLTKPYAQFKSELIRRAVPADFVWTQLAELHRLRQAPGHNIDAFQEFSDQMRSLQMEIGFQVVSNQEVAKLVLLGTDPELCRILRTHMVLSLAGWSDLSLEKLALDAPVVPTSPEAAEVFSDAHTDQPLEFNYQVFERIGCEEWSVIAQRRQAIATQVSALQQRPTYSRPAAASAAPHVATAATGHSPITGGPRPVARLTVDKRAYLDQNHGCYRCRTLNADHISRNCPRYLSPMGASATPSTPTSTAPAPRPGPRMVAAIRTFQETGDSTVFAGLSSDSEDNNDPSYAPHPFPPLPISLAGAHGTLLASALVDSGSPQTFLSEELVQRLVLERRALEQHSKYTLAMQNQVPTVFTCTHFVRVPLELANGLWAAGPTYAEVAPLGKDLAIILGGNFIYRHKMELGLFPQPHLTCKANPIHAIDLLALSSQPCAAARVAAIAPVSDDEEQLRLAALDHRLRAEFANRFPADIPPVHSYQSPVRHRIELDTPSTVVNLRGYPLPKKYREAWYLLLQEHLAAGRLRPSRSAYLSPSFIIPKKGCDVDPTIAPRWVNDYRELNKHTIKDRTPLPLPDDILSMCSNAQFWAKIDMTNSFFQTKMAEEDIHKTAVSTPWGLYEWTVMPMGLCNAPATHQRHVNKALQGLLGTFCFVYLDDITIFADTLEEYEARVRQVLDALRRAELYCSPTKTNLATAECSFLGHIINRAGVHADPKKIQRIEDWSLPKTVKELRGFLGLVQYLRKFIPGLAEHTAALTPLTRQGLSSIATLWTPNEVRHFKAIKAIVTSLDCLRPPDHSANAAPFWVMTDASNHGIGGVLLQGQEWKVARPIAYWSRQYIPAERNYPTHEQELLAIVEALKEWRIDLLGGHFHILTDHSTLEHFQTQRTVLSCRQACWLDTLAKFDYDLRYLPGEDNIVADTMSRYSFTDPLPTLVAAVSHVKLSDAVKQQILDAYKTDPFCQQAMSNIGSVTSDFKIVDALLYLRGRLIIPSLAPLRESILHDAHDAQGHLGDMKTYRTVQQAYFWPKMSRDVKHYVQQCDSCQRTKARTTRIAGKLHSLPVPTRPMADIAIDFVGPLPANKGFDRMLTITDRLSGYVRLLPAREADTTAEVAARFHEGWHRLFGLPQSIVSDRDKLFTSKFWTALHKRLNIKLQLSSAFHPETDGRSEKTNKTAFQILRALVNKEQSNWAECLAVCEYAINSSLNVATGKTPFELVLGYTPSLAPLARVDGDDNLPSVEELLALRFQACEDARDQLAISKVRQAAQSNKKRQDEPSWAVGDLVLLDSSDRQKRLHTRKRRAAKLMDRFDGPYRIVKAQPEILSYTLQLNGDDAAVPFFHTGKLKTYRKNDTALFPNREPARLGPVDVGGEPEYIIEDIVDERIRAGKQQYLVSWLSWPSDSNSWEPAEALEDTEALDRWERRNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MT91</accession>
    <name>A0A2X0MT91_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C002g01337 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C002g01337</name>
        <name evidence="6" type="ORF">BQ5605_C002G01337</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY32234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MT91"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35317">
        <property type="entry name" value="OS04G0629600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35317:SF23">
        <property type="entry name" value="OS04G0629600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="4">
        <location>
            <begin position="310"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Retroviral polymerase SH3-like" evidence="5">
        <location>
            <begin position="600"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="3">
        <location>
            <begin position="797"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="242"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY32234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1035" mass="115697" checksum="3C51BFE03C2DB5A9" modified="2018-09-12" version="1">MSPSETIAQESEEIKIAKLGKDNYELWSIRVEAYLESKGYVSVLEHGHVRPSDVSLAEWRTMHGLDASVTDTQVVVNLQKKDRSARALIIQCIDDANLKMVKSKTLSAKDIWDKLRQHHEGNAKPFKIRTLLMELSNAKYDEDENMGEFLKSMIDKADQLDDLGQKFGDEAMIAYILQALPPSYEMLKQAIRLGENRSVDHVINRLTDEYTERKLSGKFDKLLKNAGALAVQSTQASHFAMDPECPKYDAKKNHGRARNRNKKKKQDSKESADSNELAKFALTVKSLDESHSLQDNVANRVSQVNQGEIWILDTGASQHYVGDASLLSNRQSGNLKVQTASGQVVHCDTYGMVRFKLKSGASLSLANVYHLLGAPVNLISTRALFKSGAKCGWEDGKDVMTIIYQGVILAKTLSGTGYALDFTRIVEDQAHVATRATVGAPLMEWHRRYGHVPKVHDREPCISSKSRASKFSELATQVTDVLQRVFMDIGFVAEDQVDFQVDVSVEEVTRVWIAFRQGVEKMTGRKIKRVRTDNGTIHPATEWNGRTLQWLVDGDRSCGPCSLQAVMEVLVVCVGLEGKTAYEVFYGKKPKVSHFHPFGSTVYAQVPKSKRSKLESTSVKGIFIGYNSEYNYCVLVDPDSDHKVIVTRDISVLEHKSEQVGVPEVTTLPVGPDEEKGPVNNNDVVVDELQDQVDGEQMPPARQNHPQWEYGDPAIKGRNPGRYEEIDANNKIPHRTRSQRRDAEQQVMYGSAISVSLPPVPSNYEEAMASPEADKWIAAIKAELDAMARHQVLIDSDLPSSARALGSKWVFTRKENAQGKVTRYKARLVAQGFAQRPGIDHNEMFAPVARPLTILSLVGTAAAQGLFLEQFDFNSAFLNGTMTEMVYMKYPKGWDRPQTGQALRLVKSMYGTKQAPQEWNAAVNSLMVERGYKRSDADSCLYVKQVDEKFIYITLYVDNGMVASNNQEFLDAEIEAFNKVYKLKRLGPVKLFLGLEFERTSDYIFVHQSKYTRDLVAMYGGGSVGSTACSGAPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MTD7</accession>
    <name>A0A2X0MTD7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerases I, II, and III subunit RPABC3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C002g01387</name>
        <name evidence="5" type="ORF">BQ5605_C002G01387</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the eukaryotic RPB8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY32620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MTD7"/>
    <dbReference type="STRING" id="796604.A0A2X0MTD7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005570">
        <property type="entry name" value="RPABC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10917">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10917:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03870">
        <property type="entry name" value="RNA_pol_Rpb8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000779">
        <property type="entry name" value="RNA_pol_Rpb8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00658">
        <property type="entry name" value="RPOL8c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY32620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="150" mass="16777" checksum="EC8657A712BD8787" modified="2018-09-12" version="1">MSSSQTSAFLFQDMFTTTDVDRALTFALHFHGKKFDRVSRLTARSSNYDMDLTLDVNIDLLPITPQTTFTLALTSSLLPEGEKETAGGWRAGIEGGIADEWEYVYKFDQDTQERVTAYASFGGLLMALSGSYRHVSNVTVGENVYLLLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MU74</accession>
    <name>A0A2X0MU74_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C064g12780 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C064g12780</name>
        <name evidence="3" type="ORF">BQ5605_C064G12780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000132">
        <property type="protein sequence ID" value="SGZ35124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MU74"/>
    <dbReference type="STRING" id="796604.A0A2X0MU74"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007714">
        <property type="entry name" value="CFA20_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05018">
        <property type="entry name" value="CFA20_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CFA20" evidence="2">
        <location>
            <begin position="83"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ35124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="205" mass="21822" checksum="8FBD955B770847B9" modified="2018-09-12" version="1">MFKHTLQVASTSASFAEDSWISLVDDATDQLIPSQPFPSSSSATTTTTTLGTPSQSTMKVGSPTTPSPTSTSTFPTTSSSKGSISGPVLHLQSPDIKTTFIRFGDSPSNTGASSSSSSGLAINAPYLHLFLKPLGQGTNFYLDVLVTDERGNSYVIRASTFQYRGPRELSFEKGLVYGRERGGVVQEGMALRGMMTELCLFEAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-10-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MUF7</accession>
    <name>A0A2X0MUF7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C007g04539 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C007g04539</name>
        <name evidence="1" type="ORF">BQ5605_C007G04539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY61246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MUF7"/>
    <dbReference type="STRING" id="796604.A0A2X0MUF7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052058">
        <property type="entry name" value="Alcohol_O-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037:SF1">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY61246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="495" mass="54447" checksum="1ADE4720F64CF071" modified="2018-09-12" version="1">MASTGRELGLYERFSHSSQRRRRAFGGSKAAALERAISDLLNEFPLLRGRIEGRYTRTPRFIERDATSVSDILDVVRDDDSSTRVEGSPSPDEVLTTRLEAGLHQANEMDVSVGPLWKVLHHDRKDEQSIVLVVHHTLSDGLGSKNLFAQLIQRATRPDETQVQIPSLLIPFEHIPQSQEQSVPGLRRMHWSFMAGIMWAEVIRPFWPFRLIASKRATVLPNPPLVPPYQQSTELRIIRSPNELMARIKARARAKGVNDANDLLMDEILLKTPVSVRDAALGHPITTGNYVATISTPPSFKAATLSTGFYSLTRSCASHISSPAERTRAEQMMLTLSLIPDPASAAEAPVEQGTGWETWLREKMENEVGTWSCTIDVSNLGVFPVPKDVAEEIEVLGWAQPGSAMGAAIGTNVRLCFASSPPLLQGVHADPSLGTIQIMSSPASGCELVVTLSYRRGTIKDALLDHVCGNFPRVLERLGRLDDSDEGVTLADLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MUY3</accession>
    <name>A0A2X0MUY3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C003g01939 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C003g01939</name>
        <name evidence="9" type="ORF">BQ5605_C003G01939</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PAT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY38003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MUY3"/>
    <dbReference type="STRING" id="796604.A0A2X0MUY3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039900">
        <property type="entry name" value="Pat1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019167">
        <property type="entry name" value="PAT1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551:SF0">
        <property type="entry name" value="PROTEIN ASSOCIATED WITH TOPO II RELATED-1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551">
        <property type="entry name" value="TOPOISOMERASE II-ASSOCIATED PROTEIN PAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09770">
        <property type="entry name" value="PAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="mRNA decay factor PAT1" evidence="8">
        <location>
            <begin position="96"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="236"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="411"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="539"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="607"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="304"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="317"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="427"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="540"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY38003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1042" mass="111162" checksum="B02DA9BA102272BE" modified="2018-09-12" version="1">MSYGGALDSYGLAEDVAVYSFDSLGDDHDLGGLLDEGMNDLNDETFGLGAGETTDNDTFASVGEYGTTAQCGFSGLAQRRMSCSRAAPRLPSDRADPARISRNAAGRDFDFAGNTSRMLANDKPLQKLDNSWVSGPAQASKSFAAAPPSSAWNSLDADPLLSGASSYRPPAPPMSYQQVASATQHPSNMRTLDEIEAEMRNQARSAGPPAPAPAPPSSKPLTLEELEAEMLRKDRAGASTAPQVQQPSAAPQSEVPPLGAAPTPAPPAGFPAQQQQGQQQPFFGAGAALTFPPFGQQPGFAHAGPPGSFPPQQFGRPTPPFGPGMPMPPPHMLGPGQSPSLPAQMLPPRGAGTPFQGPPGAPPMMNTLFPPLPSQAGGLALVEQQLQFLTMNQHAQHPSLTSAQLQSLLQQAHSQANTETAAAPVGEKGDTVEGDEELKKKAGEDLIKVVEQRILEHEMLEQKRKRKAMKIAAMAKHNNLMSNSDKDFITRIQVSQLVTDDPYADDFYFHIMAAIKMSRHQAALAAGAAPGTVPFPPLGMGPGGPGGRNGPGANANNNRRPTRRENAMNRMAQNVQRLVDSAKQRNKSGQLSLDGALGKIALRTRSAPRQMLQVKPDAAGANGSSKKGSAEDKDSKPSTGSHLLEGLVTQSSETANATSADDGKPLSHRSVLAILEKVYDAVLDLEQLRRIQPQLLGVAAAAKDHHASAVAANASEEVQANLEQHVVEGQNAVDEWTQKYDQLANKLWTELRVMEPLDRCTPHPFIALISVLKGKRILPRALRHLSPEQTLTLLTLMVATFDTLDTVQDAPILDSLDETSGAGSIEGKQRRAVVETKTEAFLNAFLAPVMAVIGQAPLRMVTGMLGLLMERNDFSKVVQSKPGLAFLTIFLSRAESIKQATPAPDAQDLEGWQRTFDHLFNSLVQQLPRLFPSTRAISTLPFGAAAYLSNTAQASGPGHLNTIRPEIDFDDEPVWRLLAALAVCAEANEQETLVSSVREKVLENVTSAKKARIAPEVAALKIRNVNLLLHSLGLDASMLNAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MVS7</accession>
    <name>A0A2X0MVS7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sterol 3-beta-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.173</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Autophagy-related protein 26</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">BQ5605_C004g02742</name>
        <name evidence="21" type="ORF">BQ5605_C004G02742</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a sterol + UDP-alpha-D-glucose = a sterol 3-beta-D-glucoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22724"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15889"/>
            <dbReference type="ChEBI" id="CHEBI:37424"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.173"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:22725"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ergosterol + UDP-alpha-D-glucose = ergosteryl 3-beta-D-glucoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61836"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16933"/>
            <dbReference type="ChEBI" id="CHEBI:52973"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:61837"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.173" evidence="4"/>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY67079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MVS7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016906">
        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13215">
        <property type="entry name" value="PH-GRAM1_AGT26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13216">
        <property type="entry name" value="PH-GRAM2_AGT26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000391">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000029">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000009">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048066">
        <property type="entry name" value="ATG26_PH_GRAM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048065">
        <property type="entry name" value="ATG26_PH_GRAM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF25">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="11" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PH" evidence="20">
        <location>
            <begin position="389"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="17"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="285"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="575"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="751"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="907"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1440"/>
            <end position="1515"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="1269"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="17"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="292"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="588"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="638"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="669"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="753"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="912"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1442"/>
            <end position="1458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="SGY67079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1533" mass="169203" checksum="B99EFB2D0A9230DC" modified="2018-09-12" version="1">MSADNSPFSKAFASLSVASPTPASDLGDNTTSASDAPTPQGSTKTETGSKQSDSAAPSDERLAASSPGLSGRDRGPGRFGGMAQMGFRSDDDEETSPTFASHRARSQSVFESRSRSHTIRGDPNATLVQMINALAVDEQDMSSDEATSDGGSSLQHPGLIDQHSIEESTSEESASEDDKNHPEGEAGPQLYNDRRASDASRRTAIASKVADTSASPERDPSDEDPTSSFLSVANARERRPTITRGADENMTSSIYAIHRPIAARRRTFNGEAGEAIKDGLYAQQGEESEPIPEDHSDEEHDEHPSKLDQGGALLKTRSSRSSTVVSGRSVARKKQLADKLTDIFGLLDSEEVIAEYSCWLFRSVLLQGFLYLTSGHICFYAYLQAKEGAVVRSGGLSVRTARTRRYYRHWFILKDSVLSWYPSSTDPFFPDGHIDLHYCTSVESSKHAEHFKVATAEKRWHFSADSEASRDEWVKTIKKAVFRCQNEGESVKICIPLETVVDLEFSNNLEFAETIRVRVYDSNEGYALDDYWLAYFSDIHLALDKMKKVLETFRKAHPERLLHGEPQSIADTTVEAAAAATGDKPEEQTTNASGLSRISSQHRQGSWSTMRSSRLRLFPSSNHSDRPSPSPLSPADSRGSQTSARTTMSPTRGLSSESSDSDHRYPPYSSLNPSVESAKSPHNWSLPSLSSVSSWVKAPPRLLLQAATSPSLRNASNTKNPCRKIVETISRGPKSASSLGPETDYSLGLEHQETEDASNADEDDEDEKRDERVRKAFGLSEKEHTLAHFSGFLYRGVPIYGKMYITTSFLCFRSISLLAHANMCLPLAEVIGVSHHRSYRIGYSGMVVTIKGHEELFFELHTSKRRDTCMQAIEHQVEFIHKELSEGKTPGDTLAYQEHRTLMDLAASKASDSSEPRPQSESKEGQPPVMFNSTTSDFVTFKPEKSLKFTCMTIGSRGDVQPYIALCKGLKAEGHKVKIATHGEFKKWVEGHGIEHEEIGGDPAELMQLMIAHDFFTIAFMKEAVGKFRGWLDDLLETAWKACQGADVLIESPSTFAGYHVAEALRIPYYRAFTMPWSRTRAYPHAFAVPDRKMGGSYNYMVSGLSCWFLITGFRLTWVASAYLAYTFQTYTMFDQIFWRATASQINRWRRKTLKLGPTSLEAMQQHKIPFLYNNSPVIMPPPLDWRENIHVTGYWILDNPDDSSSSRWEPPQDLLNFMNEAKEKNKKIVFVGFGSIIIPDPEGMTRTITAAVEKAGVYGIVAKGWSERAASKHDSEEEKQRLKEQEKKQAEVLKKPFIYNIKSIPHDWLFPKIHAAVHHGGAGTTGASLRAGLPTIIKPWFGDQHFYADRVQTLGVGTAVRHLTVETLASAIHKAVTDEKQIDRAKLAGQQIRKEDGVGAAIECIYRDLEYAKSLIPPPPHVLKRKSTDSAGHQDVIAKQADQTAKSSPINPSSSDEASWDVVSGGGSGSASGRGERWDDDEMSELGSTPTKSRGASETRHPSDQGSVPAPIALTTKVLESLGVTSGGSSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MYK7</accession>
    <name>A0A2X0MYK7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00684 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00684</name>
        <name evidence="2" type="ORF">BQ5605_C001G00684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arylamine N-acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY48716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MYK7"/>
    <dbReference type="STRING" id="796604.A0A2X0MYK7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2140.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001447">
        <property type="entry name" value="Arylamine_N-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053710">
        <property type="entry name" value="Arylamine_NAT_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00797">
        <property type="entry name" value="Acetyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY48716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="136" mass="15663" checksum="36B3C5D4093DA57A" modified="2018-09-12" version="1">MAKGGPRVSPQRWTVWNKVEATASTKEYWTPTYSFALATVGSADLEVLNYYSSNHANATFVKLFVCTKLHREAGRRTTLYFREGMEYEGSRCARLHTTRKNENDPDGRWIDMRVGPIRQILRDEFGFKFPEAYAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MYZ6</accession>
    <name>A0A2X0MYZ6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C001g00864 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C001g00864</name>
        <name evidence="3" type="ORF">BQ5605_C001G00864</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY50220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MYZ6"/>
    <dbReference type="STRING" id="796604.A0A2X0MYZ6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036286">
        <property type="term" value="C:eisosome filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028245">
        <property type="entry name" value="PIL1/LSP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962:SF6">
        <property type="entry name" value="EISOSOME COMPONENT PIL1-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13805">
        <property type="entry name" value="Pil1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="318"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="368"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="620"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="385"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="428"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="463"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="482"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="566"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="691"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="746"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="792"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY50220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="804" mass="85561" checksum="1BA17322D0431115" modified="2018-09-12" version="1">MAAFLQKVQHSNRVSLGPKELAPLADIIGAEKRLMDATQKLAIEGTKASTALKEWGVAEGPDLGDILTKISMLYDYASSAERAYAEHTGNARLHFKEIRTREEHLTSLKKSKETLGNKIENLDRKVSKMKEENKDLPASIHRLSEMRSEMIGLEHSVLNEESKLGDFKRSIVREAMSLKLGALLEMAEKMVVVAELGKLMIDEIPTERTEPGAPRAHYNSYDRTDELMQQAQRCIQDVVFNPVPLGEGRQYDHDRYRTAEDDFRAAQPQNGGAPVDDYRGGYGGMAEEKQWSGPNDYYGGQPERYVSESQAPALPEIYSQPLLPPGAGSGGFSGNKGREQQQQHDQNGSNGALAAPFAHYEQYNQIAAPYSGSNGSHAPYVDAPSGSNRLSFEYPATTQDPSQRRASYEQESPALTKESEQAEDAARATQQPNPWRQNSQPNVASTREAKGHNQAYDNGSDVAPAAPSPAYAAQAERPRTPVQEQQEQPTYVSPSAIGSNALPNNRASPVGGGVSVFTHPDYDRPYVPKAGDGAYHGQPAGVPPPPSNANASGKNTAYLPPVNSAPAPPPITPTPTSPFSSSGNRRPVVIRGESALGSKHGDVFVANRAPIDGGALNAAAPSGPNVSSSGYAAGTGGGGASGYYRSSDANNGSGKIPAGAFRRGPSNQYMGGGVAAGGQMLPGPPRANDFGPSTTTNGTSPSPSESMSIRDQYLARDTALLQQQQQQQAEGFAGVGAGPRFDVTPLNISNRNSVMGGTAPSEVGSSIAPPSYHPSAPSQPPFSQQQGPRSGTGFNSSHFVTRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N174</accession>
    <name>A0A2X0N174_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C007g04441 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C007g04441</name>
        <name evidence="1" type="ORF">BQ5605_C007G04441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY60496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N174"/>
    <dbReference type="STRING" id="796604.A0A2X0N174"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY60496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="467" mass="50849" checksum="CB6AD832A0AF8E94" modified="2018-09-12" version="1">MSYRRWHFFLLFLPFHTLRSTFYMTNTAFFKSPMSNLLSAAVTLLALSHSGFVDAMRIPSRDPSSSLSERRFPIKRSPRVIPCTGTMRIDENTIQCPAGLYPSADGRCEQSFADTPTMWRTLAHFRMHFQFTGRRCIACQDPYAITCTSAGATTCKSGIAPKDGYCLTSWDCNGAPPRYLAPDNLSCYPCPGQNATSCDRTGASTGCSYGVPDNGACVAVKCPTSSVNTDGNGCCSDPYAITCNSGGSLSCKYGSPSDGNCPKPADCSGLPARYPSKDQLSCLDCPTNSTSCDDQGQATKCNYGALTAGQCKEVICPNGPVSNDGEFLIIPFQVPARWGSCCTNFTTSCQNANTSLTCQSGYKVNGTVNGTIPCQGPYSSRYGRETYKYGDAGRWMVAYLAQSSVETCAIQAYQRNLTFMWTAYTGREDWGAQHWYDFGKFGTCAETTQNWPVGREHASECEDLLMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N2P4</accession>
    <name>A0A2X0N2P4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C004g02724 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C004g02724</name>
        <name evidence="1" type="ORF">BQ5605_C004G02724</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY66928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N2P4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY66928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="49" mass="5299" checksum="5B6A6EE050A99802" modified="2018-09-12" version="1">MLLYHVNNPSECIDLCFSCSIRLSPLLAGDDFAGQSKQSWAIKSAAPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N4J4</accession>
    <name>A0A2X0N4J4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C005g03386 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C005g03386</name>
        <name evidence="2" type="ORF">BQ5605_C005G03386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY74880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N4J4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016166019" evidence="1">
        <location>
            <begin position="27"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY74880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="389" mass="44586" checksum="A18A37C016591BE5" modified="2018-09-12" version="1">MKTPKLLSPLVAVGLFYWLVVRRREAASGLVDPIQLVDPDPHTDKLCDPFAEPGFLHYDAENPLGTRWIPYSESCEPAPDWLGFLTQKDTNRLSFLKDRTILILGDSVDRNALHHFAEMLGLPRYCVPYDDFSQKGVVPTGWDDRGIPWVIEVPWLGLTLTNGFFYGVDDEDNFKQQPDWHAPGKAEDRIDQLFKVHTAQLPQEPSFISLHSGLWDLAFFGRQDRAWQESSEAPLSNERVRFWVKRAAQILEHTRKTWPGTPVWYRKLHRVGPVDQASYDFRHDGKAEAAPEKFSNFFTNVRTHQLREMMDAVAIARGAPVFDFGGLFEGWQRHQTGAHPDKYPAGPLYISALIHHVYMEQIGREKWRLSHQRDLFPVTGFNNSAPVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N6N5</accession>
    <name>A0A2X0N6N5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C008g05307 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C008g05307</name>
        <name evidence="2" type="ORF">BQ5605_C008G05307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY80127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N6N5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY80127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="572" mass="62468" checksum="77150B57D164F97D" modified="2018-09-12" version="1">MTVKHGHDCLGDALEVVPDALLSRKTNLSSALVSLVGKIDGKSLPQSPFAALAIIDGATAFARQRKAATDQAKHNEPKRGRLFLNAIIRHLEEIIAATARRFQVVVVFDHPILRPKLKQDTVLDRQDRQKPQQPSDKSTPVTHPVPFITNDTLAACVHGQSSKEWEVDFCNGNEPTRVATFVRWSEQGLLVVAAHEADPLISASTKFGQICDVALESNRVVLVSADSDFFMLLGADQARYRGVLSVKDQNISLVDLTVLDAHPAVWNSRQRFVASLIFGCEYFRGITGIGPTGLRNLPGQWLDAATWQSGWDGAAGALIRNVDSEPAPTEKRIKEVKFLCDEIDPIQDLLHYYKDETIAKATKASITAVSQGYRVRFEGTPHEDPSKVSRYAYAPIRRNPALVHQPGVSSTGPLPSLSSISTVQDPELRRDHAKAGRSQAEQPARMVSTHKLAVQGTVRASDYRLVDPEFGDSAEQRTRKSNNPKSIERNKATTAAEVRALFSKHSDSGSSGGGGKCPGGVIYKMSTMTGTLDDLVREPCSLELMDVDSDAALVVDESDSRSYSIAAMEIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NCW0</accession>
    <name>A0A2X0NCW0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">BQ5605_C021g09274 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C021g09274</name>
        <name evidence="13" type="ORF">BQ5605_C021G09274</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000083">
        <property type="protein sequence ID" value="SGZ20417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NCW0"/>
    <dbReference type="STRING" id="796604.A0A2X0NCW0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000023">
        <property type="term" value="P:maltose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000254">
        <property type="entry name" value="MAL31p Maltose permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF5">
        <property type="entry name" value="ALPHA-GLUCOSIDES PERMEASE MPH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="101"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="496"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="526"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="12">
        <location>
            <begin position="108"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGZ20417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="598" mass="66442" checksum="FBB6E73212ADFCCB" modified="2018-09-12" version="1">MPISSTTNHDFDKSVSTGMVDASQVHKTVVPERRSPVLASSREHTWAMSLLADYFDIVRALLHSPQMLENVSTNLGETTVNDAAETAIKERQMTMFQAIKAYPYACAWSMLFSTAIIMEGFDFTMIFSFYALPAFQKKFGVPIGGGKYVITPAWQTGLSNGAQVGSILGLMVNGWACDRFGYKKTICTSLVLITCFIFITFFSVSLPMLLVGEMLCGIPWGVFQTLTTAYAAEVCPAPLRPYLTTYVNLCWVMGQFISSGVLKGVSGMNENDQWAYRIPFALQWIWPLPILVGAIFAPESPWWLVRQGRLADAANSLTRLGSLSAEGFVDVDAKINQMIFTNEMEREINAGTTYFDCFKGTNLRRTEIVCMVWMIQTLAGSGFIGYSTTFFERAGLSSSNAFSLSLGNYALGAVGTISSWWTMQWFGRRDLYMWGLLAMSIVLFGVGGSGFGKSSGASWASGALIVVYSFLYQFTVGPVCYCLVAEIPSTRLRAKSVVLARTSYNIIGIINNIIFPRMLSPLSWNWNAKAGFFWGASCLLCTIWCFFRLPEPKGRSYLELDIMFEDRISARHFKTTAVDVRAHARSDEKHYEPMGGVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NDW8</accession>
    <name>A0A2X0NDW8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C023g09657 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C023g09657</name>
        <name evidence="3" type="ORF">BQ5605_C023G09657</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mo25 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ23899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NDW8"/>
    <dbReference type="STRING" id="796604.A0A2X0NDW8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013878">
        <property type="entry name" value="Mo25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182:SF3">
        <property type="entry name" value="PROTEIN MO25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08569">
        <property type="entry name" value="Mo25"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ23899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="391" mass="45076" checksum="1F59973249CFB055" modified="2018-09-12" version="1">MNFFKSSSSKIKTPSELVRSTREAIQRLDSASTSAEGKRKRVASADELSESRRSFADDNEERATPAAVDRVCGASEDMSKNLFQMKLLLYGDGENEPQPELIAQLAQEVYAKDILQLLVLHIWRFEFEARKDVSQIFNNLLRRQIGSRWPTVEYLSAKEETIFAALKGYENAEVALNTGMILREMLRHEPLARTLLYSDRFYDFIDYIEQTTFGIACDAQANFKETLTRHKSMVAGYLDENYDRFFSSYALLVQSTNYVTKRQSLKLLGEILLDRTNFKVMTRYIANEENLKMMMNLLKDRSKNIQFEAFHVFKVRSVLHVVEAGAPMSSPVILSLAQVFVANPKKPPQIEAILKRNRMKLVTFLQGFHNDRDDEQFTDEKAFLIQQLQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NLI3</accession>
    <name>A0A2X0NLI3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C011g06494 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C011g06494</name>
        <name evidence="1" type="ORF">BQ5605_C011G06494</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NLI3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY12401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="110" mass="12642" checksum="7DF42DC559187BE0" modified="2018-09-12" version="1">MLRRREVFPQLAFRVPKEKVARIGAALLEIDMDVVSEMIKKSKDTKRYKATTKAEKQINRILAEWQSFGDKPHGTTAQMLDMRNEIRGYANAFGILGRIKDNFLDQADTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NR15</accession>
    <name>A0A2X0NR15_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C015g07991 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C015g07991</name>
        <name evidence="2" type="ORF">BQ5605_C015G07991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY18156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NR15"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY18156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="59" mass="6895" checksum="A8EA6D16A25C6AF8" modified="2018-09-12" version="1">MLSFVLLQLGPLFRYDSREWSGESNDNMREPIHYYGIMILLLSVLISMLRLVPGPLRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NRA3</accession>
    <name>A0A2X0NRA3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C011g06258 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C011g06258</name>
        <name evidence="2" type="ORF">BQ5605_C011G06258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY11745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NRA3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY11745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="130" mass="14542" checksum="401B4F76539913E1" modified="2018-09-12" version="1">MRNSGEIDMTNSFFQTKMVEEDIPKTAVSTPWGLYEWTALQGLLGTICFVYLNNITIFADTLEEHEARVCQVMVKARLLSSLTGSESKLKGSNGVIRRQRKTTKRTKVKRRGGAVREGKREAAEVGSRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NRP0</accession>
    <name>A0A2X0NRP0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C011g06378 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C011g06378</name>
        <name evidence="1" type="ORF">BQ5605_C011G06378</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NRP0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY12072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="68" mass="7953" checksum="30A457D0ED222ED4" modified="2018-09-12" version="1">MDTRSTHLIRCRAKREEKTQFATRGIRPIKFYSGTLVLARTPHRPPRLLAAPSNYQLVLDGDHLRLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NSP2</accession>
    <name>A0A2X0NSP2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C017g08538 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C017g08538</name>
        <name evidence="1" type="ORF">BQ5605_C017G08538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY20226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NSP2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY20226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="56" mass="6117" checksum="E689D52401C833A7" modified="2018-09-12" version="1">MGGSASGNDEEIQSLNGKGMVRAQYLDADGMYVRNDKGDMSLCEYTCKHDQTDNVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NSX3</accession>
    <name>A0A2X0NSX3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C011g06419 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C011g06419</name>
        <name evidence="3" type="ORF">BQ5605_C011G06419</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NSX3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="2">
        <location>
            <begin position="370"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY12191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="519" mass="56255" checksum="291E49023A987156" modified="2018-09-12" version="1">MSSASEPNSHNGAGNRLYLKDTKGYKSWASKAYLDLRGDALWDVVIHSVDSLVADYRSTFVSANATASAAPVEPASPALSGSGGRSGSAPSADVLPTLTSVQIADKVAAFRDKANRRNELACKFLANALSEEQMGHCEHFDSAKDIWDTLKGIHSLGQSSRTMDLLSVLMQPYTGDIPFKEFVNKGQRSRGTCGIGKLARAWRGAGWRQMAIDFKNLGAPLPNWLFAAMLVRSLPDQYNSIVGNLASDVDIHMDWNAFYPKLLMNVELAESRNRQKASLSDRIVDDSSLVARISTTAPKNYSKSYCSRCKVHGHERGWRLCPSRNNNANVSAPPSDSNSNSNVAAIGVDETALMTYTFPYSKAMPVFPRIIDSGAKVHCVGDKSVISDFISEPLGISVADQSRVDSPGHGSVTFLTSYGCHITLKKIYYMPDAQCGFISIDRLLELMTYVVGPQSNLIFSVRGKSILRFRPGRGFILDAAPIQPILSSAPPSMVAANCLTGTCTLMEAHRNLGLSLASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NVD0</accession>
    <name>A0A2X0NVD0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C002g01054 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C002g01054</name>
        <name evidence="5" type="ORF">BQ5605_C002G01054</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY29450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="605"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="261"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="906"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="916"/>
            <end position="925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY29450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1707" mass="188355" checksum="61944E3A8A5BDE83" modified="2018-09-12" version="1">MASPTADHVSLMGDLYGKVDATNWGVARERLQNVLKGEGRLKHVTGALDAGPEPLQSEFTRLEGDNRVDDVATYRNQLRLYRQDVDALDQALAQARNTLIVCLGESTFARVKANATHDLWAALDKDLGRASDDFMRSAKLDALFLCEPFVDGDALDPWLANFNRLFEDLVAAHVSRDKAYQRARIDGTSFTQSNFDKWVPPPALSEGVRMDLLKARMPRNLVTVIDSIGTLPLLEQVEGAIRRAALSSSQQTEPIAEALAARVQSRSQPASGRPRSKPSGRPFGTSAPPFLQASRVPGLKERWPHGISHAGRLKLGRMQCRRCYEQGHLGDECTVPSAEVSRRRIAVLAKHNITIGAADVMALVAVDRAPEAQLEDEAYEGYFVVGVPIGDDDMALYLSDIPRYLLDSGATRHMTTCRDLLIDFKPFTTERVRVVGAFNSSAMATGTGTLRFGVDEASIELHDVLLVPGLSAELVSLAGLMKDGYELSNECDAVGKHTGIVISSATSRLSFALDRNHYVLQASSHPPRADHLVLTATTLPTDVVLWHQRLGHPSWGRLVERVRSGQIPLDVAAVTPDQIRLLDQCDACCAGKTVSSPNREPASHPVDAPFSRVFADVWGPSPVPALSGARYLCGITDEFSRFRWARSIRLKSDSAAVLQDFVAMTKTQYGGQGVTTLRTDRGGEFVNHRLRDWLAARGIFHELSTAYEHGQMGVQERSWRTIFNSVRAWLHRSGLPPTLWDEAAHAAIYVINLLPSSPLQQHTPDSVLHEPSDPVTDTRRPRLDRVKTWGCAAHVPLAPEPRPNKLAPRSRLCYFVGYSSRSKAWRFFDPVRNKVFESSQARLFEDRFFPAAVSPAMPAIPVAVGLSYPPALLGISSDAAPPVAEVPAVAPAAAAPPPVPPALAFSNPGPINAPPDGDRSTRTRRPPDYLGFAHAAQHWEFAEHAAIQFDNFDEGDPDTQMYSFEGVSALLAKIDSDDTPSVQAALAGPFRDYWLAAMSVEEGALTAKNTFSKPVRPPPGAIVIGSMWVLLVKRNAEGQIVKYKARLVARGDMQKRRGVHIDSFSPTGRAASHRLLLALAVENKWETRQFDVSSAYLNGNLGGTEIYMRLPGGDIVRLQRALYGLVQAGRECDHAVFVRKEGDRRSFLSIHVDDGLLTGDGDLDGVLCQLKARFEARSTDEASFFLGQSIRRKGKTGAAIVNQGHFVDAILEEHHMANASPRPTSLAAPSTLRNRADSGFDPASIPYRAIVDKLLYLSGTTRPDIAFAVSKATRFCNDFTAEHWEALKHILRYLVGTRNFGIRYQKSFQPMSAILEEFADADHGADPVTRQSVSGYVFMCAGGAIFWIAKRQTLVTLSSTEAEYVAMSYAAREGIWLRRLLADLGFEQTALTRLRGDNQSAITLAKYPAFHARTKHIGIHFHFIRDHIAEGTIEMVWVPTGTMAADVLTKGLGTQKHYQFLHAMGLIDSSREGASCARLFSEAWRCAPTVVFSPRLDYTLVSDQHATRLRRTTQASQAELSSPYTPASARLQAEIRAEWNQYFTDANFRVFCCLVCSERVFGHEAQWVAKTRSVLKCRDRGILEVLTDVHLRSDLRPTTYDFEEWRAEIIDPRGLHWRNDLEGQPIYFATDESSVQCSLCPGCYQSLFTCKAAPTKPARSLSNRLYRAIDHLPPDVKGCFSGASQLELSRVSSSARLVLLVVARRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NVN3</accession>
    <name>A0A2X0NVN3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C002g01164 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C002g01164</name>
        <name evidence="1" type="ORF">BQ5605_C002G01164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY30561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NVN3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY30561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="177" mass="19347" checksum="C09FC19884639068" modified="2018-09-12" version="1">MRMALVEPLRSRKLAEVGERPLPAELVAGGDRGNWIVGMPFVPKPPTPYEFLIGDTGGWKPCWGISGVVEDCATDVRRRPLKGCNACCVSRADGGAALAEALRDEPPLGADWTATNPGMSRRVSPITFIRVGLSKTDLQFVGRKRLDQSLDRRFESARASRTLLQVSGTRDRRLSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NWP8</accession>
    <name>A0A2X0NWP8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="5">6.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C002g01604</name>
        <name evidence="7" type="ORF">BQ5605_C002G01604</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = (6R)-5,10-methenyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="5"/>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY34263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NWP8"/>
    <dbReference type="STRING" id="796604.A0A2X0NWP8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407">
        <property type="entry name" value="ATPASE INHIBITOR/5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006806">
        <property type="entry name" value="FTHF_cligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="14"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="177"/>
            <end position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00036539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY34263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="244" mass="27246" checksum="485BD42115DE4492" modified="2018-09-12" version="1">MSSSASTATTQAAKALLRKSLKRRLKLVPRVQVAQESAAIAARVLAASWYLKADAVSCYLSTPVGEARTDSIILDALSKGQSRPSEPGILHREKLRIYSNTGKRVFIPFCPLEQPAVMRMLRLKSAQHFESLQLNRWGIRELDPQEVEALEDAESEQSGGLDLILVPGLAFDRKKGRLGHGRGYYDRYITETGNYSARFNKHPPFTAALALQAQMIEQDDPDQIPVTEWDRRPDALVTPDEIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P1D0</accession>
    <name>A0A2X0P1D0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g03867 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g03867</name>
        <name evidence="2" type="ORF">BQ5605_C006G03867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY54339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P1D0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY54339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="115" mass="12206" checksum="FFA78C18BA7D1A3C" modified="2018-09-12" version="1">MNMTIAELLAFDVAPADASLHIELSKDELTHYSTLSSTRGPTSSCSTQGRPMDSSDPTRGEAGVGVSNTQEGRSTTHSSVLKGLVQSMGPSRCKDMAGTTRSLNENFSTPRTKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P1X6</accession>
    <name>A0A2X0P1X6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Vacuolar protein-sorting-associated protein 36</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ESCRT-II complex subunit VPS36</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C006g04137</name>
        <name evidence="12" type="ORF">BQ5605_C006G04137</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the endosomal sorting complex required for transport II (ESCRT-II).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the VPS36 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY56462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P1X6"/>
    <dbReference type="STRING" id="796604.A0A2X0P1X6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000416">
        <property type="entry name" value="Vacuolar protein-sorting-associated protein 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021648">
        <property type="entry name" value="GLUE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037855">
        <property type="entry name" value="Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13128">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13128:SF12">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11605">
        <property type="entry name" value="Vps36_ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51495">
        <property type="entry name" value="GLUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GLUE N-terminal" evidence="11">
        <location>
            <begin position="11"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="233"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="344"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY56462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="711" mass="75272" checksum="1034F12CEE983BC3" modified="2018-09-12" version="1">MALDRYCTSIDVSLQTLSASLYPDETLLQAQDGVGLYDGSVQLPPTFSMERAIIGKLTPPHGNARSKEKSPNHFAGRLHLTSHRLLFVASHKPHRYSLALDLAHVRQTEYYAGFLKSSPKITLLLGSPDAAATSINGTTAATTAAGFLSSSSASSQSAALTTSASTSAPSPLPAGSIASPTPTSSSASGRRTWICRVCGMSNISSIKCSLCGITRDKLITSSSQSASLTAAASAPSPSASFPASPAPSSPALRSVASRTDCSQSSTPPPLPPLPASLLGPTSQQRPDAENSVPDPAALNLVDGKLPCPVCTFLNHHSMSRCELCDSPLPSLRPAPTLSAPRRGSLSTSRPSTPDSLASSNDHFMRLSFRTGGEREFYNALKEALARKAWDWQSANALLRPSKSSNGSSEARALGAINERAGGIVAIMKSFTLEAADRDQSLESALKDLQSLMSKAKDMIQLAQSINERLAQANAGSTSTAGTSTPAVSTSEKTAASSFATSSLASLGLIELAITPDLINESQRYHEEIAKELGTLLNGSDAVVRRRGVVGLDEAWCAWNRARGVALISPKDFRLATPYLPMHTSPMLSLLTLPSGLTILHTSRYSLPVFSQRIWDLLDLEQAISLSSRQSPDEPLRMQGLSTIEIAQSDDESHGGGGEGIGIGLVKELLEMVETWGEICRDQGGAGGGESEVRWFRNYFESAGRDWDGTKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P2M9</accession>
    <name>A0A2X0P2M9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01779 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01779</name>
        <name evidence="2" type="ORF">BQ5605_C002G01779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY35563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P2M9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY35563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="70" mass="8363" checksum="2DFF5603073BF002" modified="2018-09-12" version="1">MSEEMDMFYVDESYSFSSWRVSPRLRRCLVGEETERKEEGRNSTKSEQGREGPLVQRWMKSNKEGRKEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P2N3</accession>
    <name>A0A2X0P2N3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g01850 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C003g01850</name>
        <name evidence="1" type="ORF">BQ5605_C003G01850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY37645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P2N3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008729">
        <property type="entry name" value="PA_de_COase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40087">
        <property type="entry name" value="PHENOLIC ACID DECARBOXYLASE PADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40087:SF1">
        <property type="entry name" value="PHENOLIC ACID DECARBOXYLASE PADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY37645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="223" mass="25771" checksum="0042A7A0E935FA65" modified="2018-09-12" version="1">MSSTTTAQESRSAPAHFEEMLDHHFECQWPSPDSGRSSALSDALDANLMLFGSIKDTYDNGYEFWVPNHERIIYAIHGGPMAGRLNYQTASVGALRWTMKQSYSDAYPSYYPSSYYQRIRKDMWQVSWVEETGTTVTICLDFSICHIVVILLIEIALSFRSSHWDYPEKAHGYKREKLDQWRELSKIGNQTTDRHILPEQATINKIYKGKGSLQEIEMEWPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P543</accession>
    <name>A0A2X0P543_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C001g00036 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C001g00036</name>
        <name evidence="9" type="ORF">BQ5605_C001G00036</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY43580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P543"/>
    <dbReference type="STRING" id="796604.A0A2X0P543"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF666">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="479"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="522"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="546"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="588"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="620"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="668"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="710"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="733"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="767"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="406"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="149"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="244"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="336"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="244"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="336"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="390"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY43580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="805" mass="85741" checksum="497FBBB8C4DF7A4B" modified="2018-09-12" version="1">MSSPRNISSSSSGGDASGGDAVLPSAAGAGRESSTSSAQVSPSLHPTTAHINTSYGSPGGVPQIPSRSELNSQHNSPRVSSPFLNPRSAAGPAASPSGGGAVSPVLSASHAPGTSPLPPASIASSITTSLNPNLTEAQKAEIVRRHLLNAHDQSRVEHRPTIHPRASSNSLIASSSTSTAEGPSVDEGEYPTPYHLQGGDVVAGVYKWAAQQAEGAGGDDSAAPSLRRSKSLVSLDHAARQHAVDNSLTLEQTPTSNTAAAAADDDDPSSASAMRVREMLDPGGFRRDFVIRKIAEQRGEDVQVTARRVSQSTGGSRSFIDFLSLYGHFGGEDLEEIEEEDEEEDEEDEIEYDGQIRGEGIPPFRGQASGSRGVPPNERTPLVRNKTTRHGTTSAAKRQGPSQGDATVSQAVLMLLKSFVGTGVLFLGKAFYNGGILFSTIVLCFIAMVSLYSFLLLVETRLVVNASFGDIGGILYGKYMRWAILFSIVLSQVGFVAAYTIFVSQNLQAFIMAVTNCRHLIPIQYLILAQLIIFLPLAMIRNIQKLSGTALIADAFILFGLVYIFSNEIKLLVDNGIADVALFNRKDFPLLIGTAVFSFEGIGLVIPITESMKDPHRFPAVLTGVMIGVMVLFAGGGLLAYAAYGSAIQTVVFVNLPQDDKFVNAAQFLYSIAILLSTPLQLFPAVRIMENGLFSRSGKHSNRVKWTKNTFRMAVVIGCSAIAWAGAKDLDKFVSLVGSLACVPLCFCYPAMLHWKACAHTRKQKVIDALLFIFGLFATCYTTSQTISMLISGGESAPPKFGKCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P5I2</accession>
    <name>A0A2X0P5I2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA-5-taurinomethyluridine 2-sulfurtransferase</fullName>
            <ecNumber evidence="3">2.8.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C005g03213</name>
        <name evidence="13" type="ORF">BQ5605_C005G03213</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5-taurinomethyluridine(34) in tRNA + S-sulfanyl-L-cysteinyl-[protein] + AH2 + ATP = 5-taurinomethyl-2-thiouridine(34) in tRNA + L-cysteinyl-[protein] + A + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47040"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11726"/>
            <dbReference type="Rhea" id="RHEA-COMP:11732"/>
            <dbReference type="Rhea" id="RHEA-COMP:11733"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:87171"/>
            <dbReference type="ChEBI" id="CHEBI:87172"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MnmA/TRMU family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.14" evidence="3"/>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY72807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P5I2"/>
    <dbReference type="STRING" id="796604.A0A2X0P5I2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01998">
        <property type="entry name" value="MnmA_TRMU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.280:FF:000001">
        <property type="entry name" value="tRNA-specific 2-thiouridylase MnmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.280">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004506">
        <property type="entry name" value="MnmA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046884">
        <property type="entry name" value="MnmA-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023382">
        <property type="entry name" value="MnmA-like_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11933:SF5">
        <property type="entry name" value="MITOCHONDRIAL TRNA-SPECIFIC 2-THIOURIDYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11933">
        <property type="entry name" value="TRNA 5-METHYLAMINOMETHYL-2-THIOURIDYLATE -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03054">
        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20259">
        <property type="entry name" value="tRNA_Me_trans_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA-specific 2-thiouridylase MnmA-like central" evidence="12">
        <location>
            <begin position="274"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGY72807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="338" mass="38597" checksum="AAC98BAE96132A76" modified="2018-09-12" version="1">MRFTLARFKPNPTPLYPPLTAWNFPLRGSKIYVACSAGIDSSVTARLLLERDYDIRPVFMRNWDALDENNQHSGGCEWEKDWEQVQVLCKESLGGVEPTLVDLSKQYWNEVFERSLGEWERGVTPNPDVVCNQEIKFRTLPSILFDKDPNAYLATGHYARLSPSSLDPLEPALHRGAYPLKDQSYYLSTSPVSALKRTLFPLGEYRKDEVKEMARNWSLPDKITERKESMGICFVGKKGKRFRHWLGMRTNSFSLDEFGQLIQPHLSHPCSTDAYLPPKPGHIVLTSGKIVGQHQGLWQYTIGEGARLPGLPSRHFIGRKDRKNNEIVVVPEESVLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P5X1</accession>
    <name>A0A2X0P5X1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">BQ5605_C001g00465 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C001g00465</name>
        <name evidence="14" type="ORF">BQ5605_C001G00465</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NUF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY46724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P5X1"/>
    <dbReference type="STRING" id="796604.A0A2X0P5X1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.60">
        <property type="entry name" value="Ncd80 complex, Nuf2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005549">
        <property type="entry name" value="Kinetochore_Nuf2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041112">
        <property type="entry name" value="Nuf2_DHR10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038275">
        <property type="entry name" value="Nuf2_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48441">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48441:SF1">
        <property type="entry name" value="NT-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03800">
        <property type="entry name" value="Nuf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18595">
        <property type="entry name" value="Nuf2_DHR10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="10" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Nuf2 N-terminal" evidence="12">
        <location>
            <begin position="11"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Nuf2 DHR10-like" evidence="13">
        <location>
            <begin position="285"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="154"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="340"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGY46724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="477" mass="55257" checksum="6DD9F5CFECDB249C" modified="2018-09-12" version="1">MAPPIPLPGALFPILSAEDVILGCQAIELHLSEADLRQPSSLLVEKIWDRWSDRLLGYTSETSNRVALDQLDKMDYPEIYESAMKSRMFFRMVQQLTDAAQIERFSLSDVANPQSGRLIDALSGIINFWYFEEEQAEDILQPLIEEQKIMREQEMELETRSNELRLKIEQERAKRLENEPKVTQAKLEIARRQQDLQAQQREGHRLEAQMKEKKAAVIGLANHLVRCSRISWTYECTDPFAIRETQMELSKEQTRLHSKVNRLQSQIVRSPERLRQSVVSLREDLDRVVGELRATEAKAHQLSGKISSLQKYKADLESCNTIARDLASDVAKMLDGQQRLAKLEEEWSKAEAAREGYEETSRNSERRLEFLRDNCSKFDEKTQYKREAGKTKKKRLEEEWSNLKQERVDFDMRTAEVNRRAVEIEATIKSIHNETYAVLDKSEALYREMVDSVGLYSLQVNKAIDAMHTACATRMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P6Q5</accession>
    <name>A0A2X0P6Q5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00706 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00706</name>
        <name evidence="2" type="ORF">BQ5605_C001G00706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY48858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P6Q5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY48858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="261" mass="27930" checksum="397EF77F3429CBFB" modified="2018-09-12" version="1">MPADPANQLLFPGDLYAQPGKVQSTSTSPHKGTGAEEVPPSTPETMMEDEDVLPDLLLTERQLLEQLGLEQELDTLGRSLLAGMRRQYPVDTENDVRGIMTMLMSGVVDKILELIFSRWSTESDAPARRKGFALSKFTGIIGYTPRKNFHQIGVQDYILRFKDGIAGGFAYEGKLDAVINKLAATPVNPAQSTSKGFKSSQSGPAGPTSETRSVQGSRRQGICGLLGLVWAANGGRQSGSAAGEQTVPIRRAARGPSGIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P749</accession>
    <name>A0A2X0P749_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">BQ5605_C001g00915 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">BQ5605_C001g00915</name>
        <name evidence="18" type="ORF">BQ5605_C001G00915</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY50685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P749"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="17">
        <location>
            <begin position="461"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="645"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="SGY50685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1238" mass="136785" checksum="74F2506E53158CE0" modified="2018-09-12" version="1">MSLTDLPAADVNTMAGPDDRASTPPPSSTSTQSQNIDVSAIGSITLTREQYEELVRYQRTRDEEAPTPRHLLPPEAPAAFPEDSKLKGDNYVDWDITMSLTVDREVCAYLRRGTIDPMWTPTVRSRWQDYALHVLARSLTPATKATIGPVVQRGGSAHDCWLALTARYAPSDAQGHSSLIMNYFGMPQCPSTWKGFIDWSNRALVLINRLQMAQLDMEQEMAARAMDNLPPLFNSWRTTFYALQADKNKLPRAEDIFASMEAVARISRNMSTPALVAKADVQTKSAAPGRKGKWDRSGLAPSNCLACGQGKHWADKCPDLVKCTKYFELKNAMKELKGASLAPAPALAATKSSWLPLLTLHRRYGHASIQTLKKLAASGQVKGLDWTYSDSECAEFTCNACLASKAHRSPFPSSLSHAAKPLALVHSDVLLFPEESINHFRYLVTFVDDYSRKTWVYPISHKNNGGEYISSTFNGYCAARGIRRELTIPYTPEQNGRAERLNRSIVEGTLALLSHSGLPRSCWDEAAMCFSHTKNLSSHAALKGGVPNHCWSGTAPLVTALRAFGCRAWATVPGHRRDKLDPKGIPLVFVGYDRHAKVYRLLDPTSTSVSLSRDVKFVETEFPFLSMPKRATAPSIRGYRPIAQPMLQPEGPRATPNQLPPPNDELPAPDHEAASVRSDATDAAEVLPLPEQVPEPPAKVKPAWEYGNLARVGPDPGKYGEVDPRNIIEGPRTRRRLVPTMIVKEQLDSGPDSPTDAFKNLILAFAATTEGFAEHDLAMVRDPANWGDVIRTGQEEVWHPPARDEFDSLLNDYEHGDITDHKARLVAHGCSQRPGLDFEKNYAPVVKFTSIRALIALAAANGYHVHQADVNKAYLHGKLDKPLYMRVPQGINLPGKILKLSKSIYGLRQAGTIWNAEIDLTLRSLGYIPTKSDICIYRHDHNGHSHYIALYVDDLLLVGPSIAEINRVLNALELMYGIKRLGPAEYILGIQPASIPMQPGVVLDFQDSSATPQDCTRYLQAIGSLMYAAVGTRPDLAYVVAYLARFSQQPSPAHWTAITQVLRYIKGTLDLGLTYRRIDVAFHGYSDANWGACLTTSRSTMGYTFIYSGAAIAWCSKREHRVAKSTTDAEYLSLLYTSGDAIHLSELLAELGHPVPGPVVIYGDNQGSLALAQHPTNHQGSRHVRISKHYIRERVAEKEIDVVYIATADMFADIFTKALGPKPFLFHRENLGLRGAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P7R1</accession>
    <name>A0A2X0P7R1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g03911 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g03911</name>
        <name evidence="1" type="ORF">BQ5605_C006G03911</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY54795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P7R1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY54795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="158" mass="18028" checksum="D864648BBBC17DA3" modified="2018-09-12" version="1">MLCNIFKNRQNAVRTFFARTESPEPARASAVSDLLRRGLLTCTYSLPLDYDLTWPWYTCNVLRETREPIFKGMADVTFPSIDPNGGFLANTVYCLARNCIPHDCSSLLYVRLRCILRFPSFAVEKRLKVACPVQRMDLTTPDTASRRAAPIECTKPRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P8C6</accession>
    <name>A0A2X0P8C6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g04091 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g04091</name>
        <name evidence="1" type="ORF">BQ5605_C006G04091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY55907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P8C6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY55907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="87" mass="10085" checksum="2EB40B906211B1BC" modified="2018-09-12" version="1">MACEVDSFHDAMYKIVPLLNASVFEANIKALEKVAHIVPYLAAIPKQIRRGFDFGIKDLHEIALEPHWFRVQTERIKRCNSQAKKDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P949</accession>
    <name>A0A2X0P949_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C006g04321</name>
        <name evidence="4" type="ORF">BQ5605_C006G04321</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY57916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P949"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY57916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="67" mass="7101" checksum="E49CEB5B0D5243A9" modified="2018-09-12" version="1">MDSSKNTNSCNKSRKRTSSGCVNCGSPSRGRSSTARFGGVTVVLAGDPKQCLPVILNGSVRIRWSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PDJ8</accession>
    <name>A0A2X0PDJ8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C008g04999 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C008g04999</name>
        <name evidence="8" type="ORF">BQ5605_C008G04999</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus outer membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMEM53 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY78953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PDJ8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008547">
        <property type="entry name" value="DUF829_TMEM53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265:SF30">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05705">
        <property type="entry name" value="DUF829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY78953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="304" mass="33807" checksum="7E514F347A293A51" modified="2018-09-12" version="1">MASKQLTRLTNSIYFAEPVRPATRKSSYEAPHIVLMFGWMDAQMKHLSKYVEGYHRVYPSSTILLVRSSQTSFYSRAETQRRALSPAVEFLRARLGDSGSAVPAAGPSSGLLVHTFSNGGCLNLKMINEMMLRSSLSRISQDDPHGRAEYSENSEVNGIPARAIIFDSCPGNGGLKTMVSAFTAPLNNWLFKAPAMVLVALVFGMIRIFNALRFKPSILEQVGTYVATQIPLVPRLYLYSATDMLIPAQDVETNAQWARQQGAKVTMLRFEGTEHVSHARREPEKYWGAVKKLWEGTGLVETLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PDM5</accession>
    <name>A0A2X0PDM5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C008g05029 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C008g05029</name>
        <name evidence="2" type="ORF">BQ5605_C008G05029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PDM5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY79070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="96" mass="10123" checksum="99D028DAE2818605" modified="2018-09-12" version="1">MKLALTEARCDCGSPKLELRCLDPHGASGVFHGTGLVAGDDGAVVEPLPRVDPELVKHDEFLELEGMGLGASPFGGVGPRNEERTRSLTEYCSAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PFX4</accession>
    <name>A0A2X0PFX4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C025g10047 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C025g10047</name>
        <name evidence="3" type="ORF">BQ5605_C025G10047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000087">
        <property type="protein sequence ID" value="SGZ27081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0PFX4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031991">
        <property type="term" value="P:regulation of actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032955">
        <property type="term" value="P:regulation of division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051492">
        <property type="entry name" value="Dynamin-Rho_GEF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN FUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834:SF20">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="485"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="776"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1048"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1130"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1201"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="776"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="799"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1062"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1130"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1166"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1218"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1257"/>
            <end position="1266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ27081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1286" mass="139124" checksum="CBB7798C0D191BAF" modified="2018-09-12" version="1">MPLSARRNVRSAPAPLKVPAILPSNLAPATPPDSGNSLLSRSSASTTNYSRRSSSDRDMPTPSTSAGSSSYVFPSPVRSTSSRGVSTSKAGLPPLPRKSSFNNVYETSGEEINTRKKMMMPRSAVVNQRCLDLDFGFLDEEPPVRSYSERRRSSLSSAGSAPTYERNRSSGVDYFQSLKRRESYTSNGPTEISAYASPPQATDRPDLSRRNDLPSHGPFRASRAFRLESTDPSVEAHSNSDADISPTQNLSVGSTGVHDGLDDGEATDQRKRLATFLDQAASAMEGGRSLRQVLPETAPARAGQAPAKSLSQLAESSASPPMPNGFSPATPQSLNPFPAIVPSQELSHAGFNTSTPVPPRISRVSGADIDHSSANAKRTTVFYTPDMVDNVPLPLSPLELEDGRPELRYVQDPSGTGLGLHTLAEQYGNSPTLLLVPSPSATEPPVIQNGARLSGVTLESNPQSDIDSSSEVRDRDDARAKMAEKRRRTIQELIETEQSYAIDMMVVRDIYLARARGLDLNSIADHVMASGLGLSASASPSSPPVKCEFDSLTFSSSSEARRLTMSSLNLNSAAGTIPKAGRRVSSAPSLSAKLVQRRATKARLSSSAGLAAPGIPVMSTKDLHVIFANLEEVADLAERFAHLLSKAKGATAVDGAEMDDNIGEVFVNLIPQIQKVYATYCARHHRAIVRLQELEPTLRTYLSECKTLSHGRTKAWDLASLLIKPVQRCLKYPLLLDQILAVTPESHPDRHDLVRANSKMLLVAESINQTKIREEVPSPALRRESKSSLSSSMTKKFLRSSSKTSTAQISTERAAERDDMFDTLAALVDSTRSSVLRLSSEMREWSKGTKAELETQVIVVEGWIDLYASLSEEPDAQDSLYHRLMVFLEEVLDPVIDGPYREVAHEVRHSLLLKSDHLLSLLESPRQFIQKRNDKMLAHSRYIAKKLPADRRGSDEFLELSARLLEELPRFLASVSKYYDIILGHFSGAQEAYKEKVQELWDFFAERFRLRDEQGMMGSQQVLANELMHRLAVGLGVSAPLLVPAPGSTSGEIGKRHLRHATNGSRNSMSSTGSTSIRRQSIIASGVPRPASTVSISNSGGGANNIHSRLQEYQFSARSQNEAPLIVNRNSITSDASTPSFTVSSKSGESSNNGPATPPVEEHQLKQGQHMQQRSSKQPFPSGVALPLARATSRKIERGIAPIPSSAPDESLHSPLQGPSFRGRSGSGDDASTGSSITATRPPGSPQCSGALDEESSSTSSNPSPTQGACCCRSVSSYVASIDDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PHR3</accession>
    <name>A0A2X0PHR3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C048g12373 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C048g12373</name>
        <name evidence="10" type="ORF">BQ5605_C048G12373</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000110">
        <property type="protein sequence ID" value="SGZ30475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PHR3"/>
    <dbReference type="STRING" id="796604.A0A2X0PHR3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034389">
        <property type="term" value="P:lipid droplet organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019388">
        <property type="entry name" value="FIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23129">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE FITM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23129:SF0">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE FITM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10261">
        <property type="entry name" value="FIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGZ30475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="325" mass="36074" checksum="3D53CF2C695CAC26" modified="2018-09-12" version="1">MASSATAARVRPSGQSSQVPAGITTPGTPTTRVRRPAPSSNRPAQLRTFITVLFLTTLLGTSYSNYTTSTDVLTFRSRLPSSTLTRHLSSSTTGSSTESLKAILPYFADKRNVINQYFTKQAWVWVTLAYIFYSLSILVFAPKPSKSAHKVQLNEPTLVQHFLTITRRFVLSTLYWYYLTQATWFGAIYRGPSLAKHLLLYSGAVCMPSTLSSTSSSLVEGNLQCTGQRGEYYRGGHDSSGHVFLMVHASIFLYYLINPSIQRVFNHSVPQKDVGLPERFVLYSILTFMGLCWFVLGCTSVFFHSPAEKMSGFLFGLGGWLFAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PII0</accession>
    <name>A0A2X0PII0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C045g12207 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C045g12207</name>
        <name evidence="2" type="ORF">BQ5605_C045G12207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000115">
        <property type="protein sequence ID" value="SGZ31584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PII0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ31584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="103" mass="11355" checksum="33494B6BCF43F4C4" modified="2018-09-12" version="1">MGGVLEGGHDNRGHHVGLAFALVRRLGYTVVVHTDRGGISSSVNTRRRPVPSHLGRRAVCASYAAWGVNECTRCQSPKYKSERADWGKGRRLGGMSRCRHSPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PJQ2</accession>
    <name>A0A2X0PJQ2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C020g09185 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C020g09185</name>
        <name evidence="2" type="ORF">BQ5605_C020G09185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000082">
        <property type="protein sequence ID" value="SGZ18452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PJQ2"/>
    <dbReference type="STRING" id="796604.A0A2X0PJQ2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42032">
        <property type="entry name" value="YALI0E30679P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42032:SF1">
        <property type="entry name" value="YALI0E30679P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ18452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="531" mass="59444" checksum="16D6A5448369A6CF" modified="2018-09-12" version="1">MASLSYASRSSTTAATRRHTQAQQPPQHDDGYRGDVYDEEEDYDRVAPPSPPLRPSSTASTSSKRAGTQGTSPPLMRRSNSSGGASASASARPSGSASVGGAPLGPRSSFGGASSASIRRRTSALGGRAEGRRPSSSSMNGLNSARIPIQPPKHPDMFDTEEEWNKHGFDIPQTHHDTIEKTQGWHHLPLFLVILPPLGAVIHGRAENWSDGIVITIVCFYLYQLIKVPWDIYYASHARVVLDTALPKPGQEGYDPQQAERRDYSVRQLKKTELLSLLVTMLVPAAGSGLLYYARGLLSDPDRYINRFLISIFAVATSVKPFLHFAKLVQHNSLYHQEQVWYPSTEVHFLRRRIETLEQDLSQLTRAFATKDDVRNLRDGVDVPLSQLSKAVRRFDRKEEYLRLSSEERFLLLEQRLEEAAQERHTQQSLIEQLRFEAHNANLIQQVVQALRFTLFGAHHHRARVEQRQLKWFEKGPFFWVFLPVNGPRLAIEYISNTNDSVSPASWQDQKAVGGIGASPMSSDPSKFTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PJZ8</accession>
    <name>A0A2X0PJZ8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C029g10638 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C029g10638</name>
        <name evidence="1" type="ORF">BQ5605_C029G10638</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ15034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PJZ8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ15034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="525" mass="59463" checksum="A9020E6F0C68D0B6" modified="2018-09-12" version="1">MTIFNLYDFHTAASGLERHIFLFSYNVVAFSYEVVAFSNPPLRPRISFPTFSRLQCHLSRSWLGIPHRFADQSVAFDPPPDQTIPSFSPPLLAISTDVTSTDTPSSYISPTDPFQRDTAFPVHMRPDASSSARVPRSADKLSALPSITDLLAVLTEVVTPLNPDRWQSAVDCFRVHRGNIPFEQLEVDSIPTQIREGFDFGLRHLPREPLTPNNHISNDDDASCEAAAKELLRLLRDGRLAGPFDYDWLRLQVGSFRSNPLSVIGKRREPAQPSKHRVIENMSYPRAYDEITEIESCNDLLAANDFPCRWTTLAQLIRQLRALPPSMQCFCFDFADAFYQVPLLPSQRLHMTICWEGRIYIRRVPCFGGRTTPGVFGNLADVTQDFLELRFPSVTIFKQVDDVIVFCPDAALAPDKGFDWTRRFTCFPNACTKVWVLHNVRRELSEWKEFLGDANNLVYCFALKPPSIQVDASFDASDIALGIVINSRASVFPLPSNWEELRDAHITVVEAWAVERAHRTQFSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PKP4</accession>
    <name>A0A2X0PKP4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C023g09619 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C023g09619</name>
        <name evidence="3" type="ORF">BQ5605_C023G09619</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ23679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PKP4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015899476" evidence="2">
        <location>
            <begin position="20"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ23679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="397" mass="42137" checksum="DDB521754F60F2D1" modified="2018-09-12" version="1">MLFSFSTLSLAFVATMASASSIDNTQMQAVVLATQAKVSGSYTFRNVQTGNCNVTSTTVSSSFTGADGKRLFAFVYTYNSLGKLPSLHHSFLIIIINTSTSTALMQTTHFCARAGSPPPVPGQQTDPAGLWPLDQLLRPVPSSNSGKANVYTQSSKKSVSLKWTRVSGTSGNSKGSWQGVSIADGSSVSLTQLGNPAGPASAGAEIGPRVISAACTSTSNGKCLAAQYGKQNGQGKDIAAVAYACRTSGESVAKQVWALVPCGTSSSAITFSKNVSRRRRSLDLEDRAENAAITEPVVVDEDEDEDENENENDVEESPLFTDEDVTEYTETDDKADFDLGKRDFSATYCILTHDHLFDQRARAVGSTAVKSAGGFTSQGMVDFNAKDKSQWWAVVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PLI1</accession>
    <name>A0A2X0PLI1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptide hydrolase</fullName>
            <ecNumber evidence="9">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C023g09608</name>
        <name evidence="11" type="ORF">BQ5605_C023G09608</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M28 family. M28E subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="9"/>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ23609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PLI1"/>
    <dbReference type="STRING" id="796604.A0A2X0PLI1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF56">
        <property type="entry name" value="AMINOPEPTIDASE YDR415C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015801580" description="Peptide hydrolase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="10">
        <location>
            <begin position="348"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGZ23609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="554" mass="60252" checksum="DC584509BD4B1419" modified="2018-09-12" version="1">MKLVLATAVLGLTSSRVLAAPRSPGGGALYLHNLNPSLPRGAPLVTTTSVAPPPECASFHARLGTRPESTDVYYLTSECLQSHRSSSSLSSASASSPFIAFDWSHGSLLWVTSSSLEADLLQQRQAQIQEVIFARQLATYQQARAQIPLSDESGGVRLVAPLPPAQGRLVQLETDTLLREWTEDPIHALQELVFISSEPLPPPSRAMLASEVGLEGPVQGGELVSKKDRQRVVNILQGLKFNPLASEKKTSELSGNTPEETFLSKLVKTLSKKAIIADVRYLSAEDQSSAKTSSERWISRHSMSEGAERASDWLLQRFRTYGFICMQHHYKNEFAPMIECSLPGIGNVPGAFANETVVIGGHFDSRGSFGYPTAPGADDDGSGTALLLALARHISEHNLVFSRKIVIAAFSGEEQGLLGSNWYARELKKRQEDVVLMVQVDMIAYTVPGEPIQMARPDKIGLPEAAYLIGNVSEIYVPELQVGYTTACCSDHQSFEAVGYASTWVFERNGAIRDPCYHNSCDLSSRPGYNFDQVHATARAVLATLLEVGGFSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PLN5</accession>
    <name>A0A2X0PLN5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C025g10012 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C025g10012</name>
        <name evidence="2" type="ORF">BQ5605_C025G10012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000087">
        <property type="protein sequence ID" value="SGZ26966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PLN5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34407">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34407:SF1">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ26966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="794" mass="85971" checksum="371FB50530597515" modified="2018-09-12" version="1">MSDPSYFSPPRRGANASSFSATTLLQMPRGASSASGVEASPTASTASWRPASTSASGATRAAQHHRIHNHSSASPLVGSPGTNAANGLESSGSSSAYSPRVYPRPPSESPTRSSKQGFNKNKGGSGGGERTGTTPSTPTKITSLPSPRKAALSPSRTRNLTTRTGRPGKVTGSRGFYWTIPLIRRRVRIRLWTIVVGLVVLVGWWKWGNGGSGLDGIGRDSSDEGDSFESNGGLRGKLNGVSEIFRNEGGGRGLKKQIKRKAFTKGNRGGKVGGQVHRAQQEEDEEGSDDDDKLVEEGQDAPPQTSGRPNRRNSQERERATKKRVGTTKDGPPSGRRASSAPKRLALQEWSTDTCQTCMVDPRDPLCVYGVDNIRLSRGYEGSGVRIRKMLSKALKGEVVRIGLIGGKISAGQGLGDKSSWFEIFSRDFQKTFPRSQFIDGSKGSSVPTAYHSYCHSASLPRDLDLYFVELDIGNGSLGSTLEEEDTLYRSLLLLPQAPAMIRVSTFDLSDTDTTTSLASALLTSRHFDVPLITVREILQSRIFSWTSSASQWFAKASDGVSTDWGVMNPKAHQVLGDVVALYVREMACETKRRQGMPKEMLEVNENEWPTQGVVGIVPRAKIWDSHSSLDNPSYEPTPFSPHCMFGNSLYAPLVHFPDPSLTTREAWQADMWDDQAGYVSSTVDSLISFSFTGSQVGLFYWQTDGIHHGVKVALQQPGRARCWVDDEALAEGAGKSVQIEAFGQERQGSRVAWMPVVGKGDGLTFAEHTVSCRIVQPSSTEGHVVRILGVASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PQQ9</accession>
    <name>A0A2X0PQQ9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C060g12722 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C060g12722</name>
        <name evidence="4" type="ORF">BQ5605_C060G12722</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000136">
        <property type="protein sequence ID" value="SGZ35393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PQQ9"/>
    <dbReference type="STRING" id="796604.A0A2X0PQQ9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000795">
        <property type="term" value="C:synaptonemal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019789">
        <property type="term" value="F:SUMO transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042123">
        <property type="entry name" value="Zip3/RNF212-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22663">
        <property type="entry name" value="RING FINGER PROTEIN NARYA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22663:SF17">
        <property type="entry name" value="RING FINGER PROTEIN NARYA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="213"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="258"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="440"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="175"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="213"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="331"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ35393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="480" mass="53058" checksum="DF7CCC1D83DC7D8E" modified="2018-09-12" version="1">MQARAADRPEGISSRASGSVRSGHFQHGIINGTGGSTLAHPPLEWVACLGCLKSHPVLLPFTEPWDNLYITTCCHVLCARCAFSGHASEIATATASAHHQPAPSDPPSTATLETLSLSCAICSLDTQFMLLDENVPDELAPCFRPLVRTLEELSAATNWQVDHLALQVAWLRHKCERQKGNLTKLVQELKRIKGELGKFRELEQENERLRALVDSREPRHEHEFRLPHRPMGLHPPSDPRYDHLTLHEAQPDHAITRREAPDNPARPSSVAALPAAPSRYSLPGTLKKQSHEWPGPRSRTSSIAARSPPQRSASVSTKSPRQRPYPRPQASPHQTLATRPASAQPTARMSPWRHPAATPPPPRASTAQGNRQHFEPLHAAQYRARQEQAGLGKIDEENTGLRATEPQWERFRPPPSPFSGTRSGSVILPHIETGTVRVSTPRQPFVPCPASASRRTGYEDTRGQSLPRGFQTARDLHRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LQ94</accession>
    <name>A0A2X0LQ94_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">m7GpppX diphosphatase</fullName>
            <ecNumber evidence="3">3.6.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Decapping scavenger enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Scavenger mRNA-decapping enzyme DcpS</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C010g05973</name>
        <name evidence="12" type="ORF">BQ5605_C010G05973</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = N(7)-methyl-GMP + a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:65388"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58285"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="EC" id="3.6.1.59"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIT family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.59" evidence="3"/>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LQ94"/>
    <dbReference type="STRING" id="796604.A0A2X0LQ94"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140932">
        <property type="term" value="F:5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000006">
        <property type="entry name" value="m7GpppX diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.40">
        <property type="entry name" value="Scavenger mRNA decapping enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008594">
        <property type="entry name" value="DcpS/DCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011145">
        <property type="entry name" value="Scavenger_mRNA_decap_enz_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978">
        <property type="entry name" value="HISTIDINE TRIAD HIT PROTEIN MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978:SF0">
        <property type="entry name" value="M7GPPPX DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05652">
        <property type="entry name" value="DcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028973">
        <property type="entry name" value="Scavenger_mRNA_decap_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102860">
        <property type="entry name" value="mRNA decapping enzyme DcpS N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR028973-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR028973-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY13777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="358" mass="40095" checksum="6F368DC159E4F850" modified="2018-09-12" version="1">MAPSSPQPTSFTSATDLLSSFHFERILSEDPKAHVAYLLGTAIPENTDVRQPTIVKVEKTAFAPDELQRLVNSSAWDRTDTVTCNSIYGTFSSWFAPGRASPDAQITSICPASDKHIRKYSQQMTRIVRETPELYEAVVKPYINSLDPNQISWVYNILNGTSEAEHVILRDEDPETGFVLTPDLKWDKKMSTSLYLLVLVQTRAIRSLRDLRPHHLPLLTKIRRECERVAMERYGIDEGELRFFVHYQPTYYHFHIHVTHVSYVGFSGITVGQAHLLDDVIDLLTLEASLPTPPRNSHYASRTFTYALGTEHALYSQLRGAIAAPPVQAADGQRPQLERGTSNLQAVQFASAAAGVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LRV1</accession>
    <name>A0A2X0LRV1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C096g13090 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C096g13090</name>
        <name evidence="1" type="ORF">BQ5605_C096G13090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000010">
        <property type="protein sequence ID" value="SGY11628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LRV1"/>
    <dbReference type="STRING" id="796604.A0A2X0LRV1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY11628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="844" mass="90489" checksum="ABE5A8A50E55F0E0" modified="2018-09-12" version="1">MPVRFRTLFVSLERQCLLPLHSRNFSTLLLPAMTTASTSTNDHAALSSTESPAATIGGAAGVHVAPLLPPMQLSGHSGAPDTTAGTTYEGVLFGISAETIKWAKDRKDPPMSRHDTNKSSESALWCGFQGADGGGSGLRRLPAAHAKAGRALSLRAPLIKEAVDPVTASIIVGGAQSPSEMFDRHFESVAMRTCDSNWSIMRKYDSTSIMAQVSAALNVAMKLAELAAEHQSSCTRAMERPVDDLIEARGRIQAMEEATLGGEDWKPILPLLKPVAVAPAACSGSPCNNYNSWRVCITNLSPLSCRAVTSASRPRRYLSGIASSASVLWFRGRIPHRSRFLTSAHDVGCLRSLVEGSYPPPLALSHVRVRVDARSRRTGWALPLPAQLRADVLDVNFQTLRLEPLSVALSEVVTSGIASRASVLVQGSNPPPFALSHVRVRVDARSRRTGWALPRPPQPRADVLDSNLRFSLPGRIPHVRASSRPRIASSASVLWFRGRISHRSRFLTSAADVLDLNFPDALSAAPADPLSITELPMHGVGRASLEPVAAGSKEDVPFVPSMPAPGPSPAPETSARMRIMAREVDSFHDAMYKIVPPLDAPAFKANIKALEKVAHVAPYLAAIPKQIRKGFDFGIKDPPSERHIAKNAPLTEEQQLVMDGEMERMLDLGYIAGPYDKDELEAAVGPFRTNPISCVPTSVAPGMPPKWRQIEKLSYPKTLGGRVGHWALRHCIANGERKAVSRARRLDRSFSTSFEALLIPSKLALASDACMHGLGIAINGYSAYFALPEGDGSATASTLGVYHECGGVGGRGAGRGSVTNVTINISFSNVTTPGLCLDGEKGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LST7</accession>
    <name>A0A2X0LST7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C012g06958</name>
        <name evidence="10" type="ORF">BQ5605_C012G06958</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG8 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LST7"/>
    <dbReference type="STRING" id="796604.A0A2X0LST7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007255">
        <property type="entry name" value="COG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04124">
        <property type="entry name" value="Dor1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="66"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="857"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY16709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="878" mass="93926" checksum="60284CFBC4C3A00A" modified="2018-09-12" version="1">MAAVASTSAQLGSWLEESPVGSQLASTSPSLGELDARATTDTNSVELLPTLSTLLLSTAKSLVERTDAIKSEPSRGTGPTASTSATTLKPPGGVSPVASFSKPTTSSTSPPFDALHHNPVTLLSDPSSNEYLASLLAMPLSTLQSLPATLAALSKSLDTDLSSLAFTRYSAFLLTHSATQSISQSFTTLADSLTALLESTSELEAAAATFEQRVDDVRRKRDRTIRVQERIDEVEELLEAPAVVEACVRAGYWGEAIDVAARLSELHARLKASKESKRYISTNAKAVLVNGTALTSTATSDGDGALRLLQKVRDDVAIALLSLRARVIDSLLQRGLKLPGAVRGIGTLRRIGSRAMSGSDPKAYSSDGPQELDENALRVVFLAARWRCLRSELEAVEGQMAASGIKIDDAGGEPPEAMPNQTSAEENEERMKWTRQWIDVWREVVGETLGMYTDVFLSSSVLSNQAASNGSESTSNPLNCTLPAAASLALFATSSLTSLSGILARAIPSLTSTAYLAGLLAQLSYCSHSFARYGLDFRELQQLRERIEARVGRIVVLEWEAAGRAWEKEWRDGWEGTGSHAISLARRASLLGGRAPMSDWLAVPEGLTQVFTTTMPPALPAGVAPSTFHHQPPHAVALLPPLARFLNAHSNALNSLRFLPPLALYPSLRVAQARELDRATQVLAAFTDAWLASSHGAAASGRDSIDSEEDDAHLSNDERKIKALRADEKRLIVTSIAWFGRWVVPWIEGSLDVGIYGEATAQRILPKERRVAGVVDAVQRTEGLIARIEGRRPIHAEPEATVPQASTSEDSQVAPVDEMATMPVEGTPVNPAIVEPVLDEVFDEARGSTRPEAAILNVPNVAPPTEESIAGKNQLGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LU82</accession>
    <name>A0A2X0LU82_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C010g05847</name>
        <name evidence="9" type="ORF">BQ5605_C010G05847</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LU82"/>
    <dbReference type="STRING" id="796604.A0A2X0LU82"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF111">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="459"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="494"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="541"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="577"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="618"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="649"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY13370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="681" mass="74702" checksum="62249E771BA953B8" modified="2018-09-12" version="1">MPSTARQRGTTTTPHASSLSRRRPRSGPSKSSLLLLTSLYATATQAFYLPGAAPKDYLPGDHVPLLVNALKPHASGWNAQVKSMVAYDYYDPHFGFCQPKPGPPKKQAESLGSVLFGDRLYDSPFNIRMLEDATCVHLCTSTLSADNSAFLADRIAENYAYSWLIDGLPAAEMKQDTRTKELFYSAGFLLGSVDSTTSEPPAAEADPDVVFKPSNHFDIYLEYHSRPDEHKRVVGVVVWPSSRDSLAGTASTPSCATSTPFVLDPTKPNKIAYTYSIIWKESATPWSTRWDHYLRVSNPRIHVLSLASSIIIAGFRTGIESRAVCGMVAMVLLRTVHGDISRYNAIDLDEDVQEDFGWKLVHGEVFRPPKRRMLLSVVVGSGAQLTAMSGVTLGESWEGLTVLVFALLGFLSPSNRGSLSTVMLITFSLFGGLTSQCIAGYVSSRVYASLKGEEWRKTILLTTVLFPTVLFVFLHLLNFFLLGAGSSGAVPFGTFMAIVGLWFGVNVPTAAVGGYLGVRHGAVEHPVRINQIPRQIPRKEWWLAPWPSAILAGILPFAAGFIELYAVMQSLFGSKVYYAFGFLALTSLIVLLTAATSAVLMTYFALCSEEYRWHWRSFLAGGGAGLWLFGYGILYWVSRLDLDGLANKVLYLGYLVLLSGLVFLVLGTTGFVSSYWFLKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LUW5</accession>
    <name>A0A2X0LUW5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C013g07250 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C013g07250</name>
        <name evidence="2" type="ORF">BQ5605_C013G07250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LUW5"/>
    <dbReference type="STRING" id="796604.A0A2X0LUW5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046404">
        <property type="term" value="F:ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046403">
        <property type="term" value="F:polynucleotide 3'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083:SF9">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY15113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="266" mass="29418" checksum="41645E8A5C7C59C9" modified="2018-09-12" version="1">MDRPSPIIPSITLNGAHSPSSSSSLQPNLPPTLPPQELIVLCGLIGSGKSTLSTSLVQLLPPTTTRHQWVRVNQDESGDRRTCEAIARSALARGHNVLIDRQNFDRAQRKVWVQLAREFKGVRVGAWVMGTSLEDCKSRLMYRQNHPTIKDAQLGIRLLNQFLKQWQEPHPNEGFDSLRILPPLPPSNAITPELLESLLFQLWAPAPTNAKRQVENNGTFGPAPIVSPWNNTTSSPYRPGPGKGQRSLDSFGFARQTPPPPPPFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LVF4</accession>
    <name>A0A2X0LVF4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C016g08175 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C016g08175</name>
        <name evidence="1" type="ORF">BQ5605_C016G08175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY20956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LVF4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY20956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="51" mass="5708" checksum="71DDD3E7074E8E77" modified="2018-09-12" version="1">MGVIRRPDLSGKTWDGNVMQIGAQSTPANSYLRRRSQTKPWACVCKKPETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LW84</accession>
    <name>A0A2X0LW84_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS5m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C012g06824</name>
        <name evidence="11" type="ORF">BQ5605_C012G06824</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LW84"/>
    <dbReference type="STRING" id="796604.A0A2X0LW84"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000022">
        <property type="entry name" value="28S ribosomal protein S5, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277:SF1">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="10">
        <location>
            <begin position="166"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY16265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="344" mass="37360" checksum="55CD914C9A787F77" modified="2018-09-12" version="1">MQSLSWLRPLVRTAATSTSTSSTRIATAAASRPLSSSACSCQQTESTPSSSSSSEITSDSGPRQRRLRFDLGAPNLRMLQTMDHASLSSFDPMLDIHPDKKFFIPRAELGNLSDLSIVLHNDDSTNQGYQQPKPKPEHLTSTPGEDDSVAHLSAVTQLTPIEIRNLYRFPLITKRVVNMKSKGKMPAMYSLVVVGNGNGLVGVGEGKDDTANKAVGKAFNQAVRSMDYVERYEDRTIWGTMQSNFGSCQIHMRSRAPGFGLRVNHYIHQVAKAAGISDLSAKVHGSRNGTRVIKLAVAMLHGGSTPVDMGGFGQTKGQRKNKKTRGMATADEVARLRGRKAVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LYP9</accession>
    <name>A0A2X0LYP9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01403 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01403</name>
        <name evidence="2" type="ORF">BQ5605_C002G01403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY32725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LYP9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY32725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="114" mass="11728" checksum="DF7B8B4BB13DBB50" modified="2018-09-12" version="1">MVDVEGDGVAVSARSAGGAKKEAAATRSGRLCPSGLLAVIATDIAVSSDPSSLTPLPNKVSPFTVFGEESRGFCFVVLRRFGAGGIDFSSTWGLSPSTLTLPAMFPTRFGCKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZ10</accession>
    <name>A0A2X0LZ10_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C002g01523 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C002g01523</name>
        <name evidence="3" type="ORF">BQ5605_C002G01523</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY33669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LZ10"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF12">
        <property type="entry name" value="AT HOOK TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="153"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="355"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="531"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="700"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="929"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="643"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="380"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="406"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="434"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="531"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="710"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="750"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="769"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="793"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="805"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="826"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="937"/>
            <end position="946"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY33669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="969" mass="104836" checksum="A15070B460B534DA" modified="2018-09-12" version="1">MDGPSRVHGATASLSASTTSTARALDQDDETRRSEAMSMSNTIMREEPRRFAPLPKRQRLQRVQPSRDEDGHHTLSTSTARSVPPRTMTMATTGKTRAACVASSKSASTLIKPQDLEVEDEQWDEHVETNRMMEQSSLTTRNQEAHQALLEYRSNDHEHGEDDQGRTSNHPTPNRRPPLVSSSSEFSFISSSSASDGYQLGEGTSSGQTFRGNTSSSPKLGSAEGDGETEDLDDSRVASSSSNTPSTVVTSPASTASSQARRPRAGDKSAGVSHDFSHDPRYAEALFPELKADEEEVDLSEESLFGQVGRDVLRLLRTSMQSLVLSIPHNAELVLDDTDIGRRINSLTGEVSCLRPNRQSSEERVPEADEDESYLHLQPSIRQELSTTMTTSEDAPALTRYDSPSPIESQYESSNGDGRMTKKRKNPLGSISIGEDEEDEEREREDESTREGMGAEGLTRYESAGGTRGKSRSVPANPPTTAKAALAKLRHLPPRLSRDFWTLGRRRREIMGDQNHHQPLELPPVPIFTPPVVPRRSVPPPLKPGSGLKGSKAIKAAAKAEKERLKEQERINALLGGSKFRLINLWDPLGLEESAAAIERARRKALANALQECGEKRAEVPTLDAFDVDGKTPPSIVKRYRVLNAAKDRLRVAELNAAKAREEENLRRLQKEKEELVREVEASEAAAAAAAAAGADAVVDPLPTTPSAPPTASVLTAPPSPKATRSTKTRPSSPSATRSSSAQPPPPSAAPTGKPSTATTVTPLSADCTNLPITSSTTYTTEPPSAIPLSTRKPPKKGKKKRSAHANALNPHHLNNYTPSRMPNRSSSGVAGSSSPHADAPPSLLSILDDEVQPLSSWPASDQVISQALLTIRNRSAGDALRFFAGPEEDICAFCDYELWFGGEGNLERSVRRRKKVLKVRKKAKERARKAANGKVAAATTTTTTTVEDQGGERLESGSGGREVGDAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZK0</accession>
    <name>A0A2X0LZK0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01683 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01683</name>
        <name evidence="2" type="ORF">BQ5605_C002G01683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY34789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LZK0"/>
    <dbReference type="STRING" id="796604.A0A2X0LZK0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY34789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="160" mass="18834" checksum="5524A65139F0AABA" modified="2018-09-12" version="1">MFPDLLVIRIALRILFLVLDSIAPFSLAWTVASIWLWPVHPLVALWPIDHLDLLLRHDFYLHNIVTGWCFIESIWWFFHTIGRHLVARGYWDFREAKQPLVAEERWRLWVKMLESFPDPWEWLGGTFLAPGLRSAPLGMEDPAITRVRIQDVGRSNIEHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M039</accession>
    <name>A0A2X0M039_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C016g08162 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C016g08162</name>
        <name evidence="3" type="ORF">BQ5605_C016G08162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY20889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M039"/>
    <dbReference type="STRING" id="796604.A0A2X0M039"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="322"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="392"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY20889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="471" mass="50170" checksum="25A3AE4CB6D603E2" modified="2018-09-12" version="1">MTGSDGQVSVLTSSSGVPTLNSATKGTGGSKKVHTGAIAGGVVGGIIALLLAIFILVALRRKGCFRSSDEHFDDDIWSPEAHGQGVVGIKARSVNHDDDDGADVGMHSGEIMSEKEAEDAAMEGSRHSYHARASSFSSEPVQPTIRRISSPTAGHSNYSRANELTRSASAAAAARVRRSVSGVSSSGHQSHESYCSAAPTHLQSPTSAAYYQSRRMSQHAFYQQQEQQARTRSPTSPTSEYEYTIGPNGGYERPMDHRVAHRRIASNDGMSTMSRHDSVVSRHQSYSNHVTSPTEVSKRQSFSSLPVLNTGALTRRNSTVASGNNSFHSSSDHSSNFATTGSTSANSHGHTHGNLRPLTSLSPTSPTYYKPYEFKRPQLEVVVSAGELPNDSLSSGVVPSLLSSNGSSEDASHDPRPPTPSSAILLDPPRPEFLQADRPKMERSSSTSSVIAPSQFLGARIVNVDEPIAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M104</accession>
    <name>A0A2X0M104_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C125g13329 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C125g13329</name>
        <name evidence="3" type="ORF">BQ5605_C125G13329</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000023">
        <property type="protein sequence ID" value="SGY27515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1087"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="455"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY27515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1820" mass="198920" checksum="C572DAD33AE32D08" modified="2018-09-12" version="1">MPDPPGAQAPPPDNPLGGNRASDDESLNTLTREPVTGGTANPPAWSTEATQARLDCEKVMQNTFRVLGIVPSGKSTRRLMVLMHDASTPPSQAPLLARAAQRAVRNDAAPASNVIRVIMDGPGSPRGPVQIALRKHFGLAETPFMFARPEGVVLDPEVEKLFSKCVKLNPIVTKATKRFPIARHMYELVFESDQACLEAAAAGPFSHHGKEMVTELPSASPLNHVVQVRFTLPSSSSATPASVLRQSLDDALTLSFGRAGRTQGYTLMQLQRGLAVDPNGDPMAMTEDGFHCAYLRLHADLFQGSTETQKAALNAALPQEIEILGAKYGLRHEFETHYCAVCDRAGHQWGACRKPVSTPATAAPVPGASTSTSTTGFRVAGKNGKHGGPAALNSRASGTNMIQLGPRANPAGAATGNKDDANDDDGDDDDDGGGESVASTEPEGGDTGKETLTRATTGPTKETQTTTAAPVSTPTSPSPSTSAPASPLSGGTSESSATSTTSIASTSPRRLRSSSAPGNRRVTRAGSAMIHGASGGDDSGGNSSGGYRSESLTVLTFNVRSIKNAVNQVKIIRYLKTLRPAPAAILLQEHHLSYNASREGFESAWPGACIRFTPHVLTLIPDGSPLAGHLLSSTPVVFAGAPRLDGRILRSVFRLEELDVEIINMYAPVQEDDRRDFFGLLHFNAPRPKTLRILAGDLNDCPDVSVDRVSITDRAWTPVSHWQTLLSKIAFNALDTVRHVHSCTPAFTRPHYRGRGEERKICSWSRIDYILVQCSWANRLLSASTLFDAPCSDHRPVVATFALPTSNADAEPPLSLPSTSDFISRLNPTVFDDQDFVASIPGVVDEVYRRLEGTAPLGDVYDAALRAVAVAGHARYRSTRADMRRLRAESQSVMEALEARGEHMNEAERDAYAFAKSRLDQLAVKEAQWLRIRAHVPSVDSREGQSASIRTRLNRRSRQTSIVSLEDVDGTETVDMQEALGIASRHAQSLFTPDPARGDPTNARRSLLDPIRAAKCYDDDRSDPTFGRRLPRQARVALDEPFTLLEVEAALKKTDSGRSPGPSGIPYELFKALPTYFAPKLLDLFNSIWEGGKMTASLAEGLVRLLPKNKPGANLKSLGAYRPITLRETTYKVLSKVLVARLNGVLGELLPPAQHGFMPSRRSADAGSHLTLLLEKLKSLGTEVFPEGALLSLDQQSAYDRVDHAWIFDVFEAFGFGERFISLLRALYDPETLGVRYLINGFPTELVRLLCGLGQGDPLSCPVWNITFQPFLDALVRRGIALDLQKVWPGGPRAQLTHLAFADDAVVVVESPAALSKLETLSQTWYEATNGKTNTDKTLVLPLGPNWLRDETAQALPTVQEGESFKWCGYAFFRHGDSKLFWTHVLDRIKAKTRAAGDRTLSPSGKVFYANAHIISTVLHVLSFDIPPQWFIKAAETALTDFVWGGAGRNTVARDFVFQAREDGGLGLISIGDIVHSVALRFWDAVAGSNEAIWAPLARESWRSLVAATRDFSPWGFFSSTARVEKLVTVPTIKSELLTLPELLSLPPRLPSLYAEGAKHAYDDADAVAKFAQIADLYWRDEGKGWALVGHRRGFWQHSKEPALQHEHVWSRVGQLLKAKALLPKTALRPARIPLKEAPRPRCFNFFGLTRPFTIRKLRRLVNVVRFPGREDRVKRFRDGTPQSDRKRFWRWLHDRFASAAEQDTHWRAYGHASSPSCLFCGNDAAVIETVGVLRILFDKLGIEDTDVDPSTFTQEQLTMGLPLLRVVGERLRSGCGFGWLRFEKDRVVAPPSIPSALRAFNRDYLSRAGFVPGARDWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M110</accession>
    <name>A0A2X0M110_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C124g13321 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C124g13321</name>
        <name evidence="3" type="ORF">BQ5605_C124G13321</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000024">
        <property type="protein sequence ID" value="SGY27527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0M110"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1214"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="510"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY27527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2649" mass="296580" checksum="26376C03AF1B1094" modified="2018-09-12" version="1">MSTGDPGSPPPAPPPPVSATSVQPPRDQIPISSKKTQATGPATAAPNYAAAASQATQSPEQQQQQQQRAKALGSLLQAMGAVPGNRMDRWVQAIYFAELYPVATATSLKFSALNANRSVENIFDYALEVTLSHQSASRASHADKTDLVACVTRLLSPISPICFEPGVPLPDHLAAYRPQILGVQHSSILRNGAAHHRVTVGFHHNMVELRINDLSGKGHLCQLVQVLRIISVDNASAFAHVAGDYSAFLHFDDDSLFKRPNTTLKEILPSRIGLPTRGIPVTALRHDYEKEAACGRCHFVGHVGTCGLDQESKRKEAHNGNGNGNGNTNANKNTITNDTNIVEAEAPIPVPVVNRIASQNRFAGLEVEEGQEEAVTGQSGQGPEESGEEDAGDKADDEDSEDSEMESEATAKTEVIKLKSEDESVLEDCGGSDGEVIDEDEVMADGRGETEGKVATEMEEREVATEMEEEDVATEVDDVDEAGGATKAENAEATDLGETNRLDNDDDSDATATAATASRESTPHEPTPPLSPETLAKSLREGEEWDRIRANWVEQARLERDQSIERRLDAEAPLVRHNFATWDEDGEIRSINIRGTAAKFKKPVMKRSQTAADLSDPSDEPTDAKRVIIKGKSRVFVKDGTEGRRVTRSMSAAAAMPVGVTKVDRGKAKGVAEEKRWSDHEPEDDRFDLNYPLMIKHTIITWNVRRGMGVPEKRRDIYNYLSLFKASAILIQEHFIRPHLWQLIKDEYEGKLFINQHCLTLIPADSPLIDAELLRTHSALDGRLLVTSFRLRGDIKILEINNVYAPVDPKQRAKFFDKLLFHKTQKSHLRLLGGDLNDCPRPEVDRRNQSRRGHHWPILIGKLDSAYTDCIRYKHPITPSFTRPNPNRKRPNSFSRLDYFLLQRTHQKRLDQASTIYDYPKELSDHRPVLIVLALSDDPDATLPQLSLPTTSNQLHRINTTTFKTVEFQRMMEGWLEGASGEEPVGELEVILKACRDRGGEMARRLHRERTERMEYLVGRVQDLEAIPEWGEAETAEWTRTSEELKRAVEERARLLRIRAHVPEIASEERLSRPVHAKLAARNSDSKITALRLSNGELTHDIDVALDHTQAHFQRLYHIEPRDPDRVDRLRDEFLAPIRAARTCDDPRSDPLFLRRLSESQIDLLQRPITEDEVVAAIGTTHPGRSPGPSGVPYELYQTAPKAWAKVLTKAYNAMIERGSLSPKQGQGLVRLIFKQHKKNADRAELSSYRPITLRECDYKIFTKVYVARLNQILPDLLPPQQHGFVKDRRSADAALHLRLLIEELGARRTEFPAAALLSLDQSSAYDLVEHDWIFAIFDALGAPATFLRVLRMLYSGDSTSARYIINGFLTAPVRLTCGLGQGDPASSSVWDIVFQPFLDALHRRNIALNLSIPALHPYPQSRAITSLVFADDVVVAVAGLGSLNLLDDLALDWRHATNGRLNTDKTVVLPIGRRWDPGQRPLVVKAAGESLEWIGLPFDPSGDTELAYANLIERLEATLEGVQHRWLTHHTRAFYVNRYAIPKILHFLAADIPPPEVVKKLDDMLVDFVRGGKGRTSYGRDIVFTAKLKGGLGVIRMQDVVDAVAARIWDVLLGGSGAIWQGLARAALQRAQSDLDLATDLWPHPSTPIPSDLHPRWRAALGVPKQQDAQVNPRTLTTANLLALPTLLGSLHTPIRGRQTIDAIHIPDYLRLQGYPKVADLYRRELYAGGGFHLWTPPADVLGDNSEYDRRGLPQRLAIAAWYRFTVDRHKNTPLAVAVAAGRLNVPPRIGTSAPLEAILPKPVARFAMEQRLPDPVLPQQASQYKLLNMARPYTIRRIRRVLNAKAFTNTLGLKGPPQPDDLRSFWKAVNSKALTAREREVWFKLILRFTPTRKLQHQQNHDTSPACLVCEAPVDDTDHYFFGCVDSRNVWIAARGVLCDALGCDTIEDDQYTTLQRLFGLPKLKAKLSEQEGAGRTIEIFTGGRGNVYDRVDHAWIFDVFEAFGFGERFISLLRALYDPETLGVRYLINGFPTELPFLDALVRRGIALDLQKVWPGGPRAQLTHLAFADDAVVVVESPAALSKLETLSQTWYEATNGKTNTDKTLVLPLGPNWLRDETAQALPTVQEGESFKWCGYAFFRHGDSKLFWTHVLDRIKAKTRAAGDRTLSPSGKVFHANAHIISTVLHVLSFDIPPQWFIKAVETALTDFVWGGAGRNTVARDFVFQAREDGGLGLISIGDIVHSVALRFWDAVAGSNEAIWAPLARESWRSLVAATRDFSPWGFFSSTARVEKLYRDSARWGAVVAAARVTLPTIKSELLTLPELLSLPPRLPSLYAEDVKYAYDDADAVAKFAQIADLYWRDEGKGWALVGHRRGFWQHSKEPALQHEHVWSRVGQLLKAKALLPKTALRPARIPLKEAPRPRCFNFFGLTRPFTIRKLRRLVNVVRFPGREDRVKRFRDGTSQSDRKRFWRWLHDRFASAVEQDTHWRLMYDVTPTRKRQHTQGYASSPTCLFCGNDAAVIETVSHYFFECAYSTSFWGGVLRILFDKLGIEDTDVDPSTFTPEQLTMGLPLLRGRGRTTSKWMWVRLACAIGFQRLHLLRWRVHQRFELDKVVAPPSLPSALRAFERDFLSRAGFVPGARDWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M159</accession>
    <name>A0A2X0M159_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C080g12971 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C080g12971</name>
        <name evidence="2" type="ORF">BQ5605_C080G12971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000035">
        <property type="protein sequence ID" value="SGY28308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M159"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY28308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="455" mass="51123" checksum="FA79FE77F39CD1EA" modified="2018-09-12" version="1">MMNVFYKKKSHLTLLLEKLRSLGTDVFPEGALLSLDQQSAYDRVDHAWIFDVFEAFGFGERFISLLRALYDPETLGVRYLINGFPTELVRLLCGLGQGDPLSCPVWNITFQPFLDALVRRGIALDLQKVWPGGPRAQLTHLAFADDAVVVVESPAALSKLETLSQTWYEATNGKTNTDKTLVLPLGPNWLRDETAQALPTVQEGESFKWYGYAFFRHGDSKLFWTHVLDRIKAKARAARDRTLSPSGRVFYANAHITSTVLHVLSFDIPPQWFIQAAETALTDFVWGGPRRNTVAREFVFQPREDGGLGLRSIGDIVHSVALRFWDAVAGSDEAIWAPLARESWRSLVAATRDFSPWGFFSSTARVEKLYRDSTRWGAVVAAARVTLPTIKSELLTLPKLLSLPPRLPSLYAEGAKHAYDDADAVAKFAQIADLYWRDEGKGWALVGHRRGFWQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M1L3</accession>
    <name>A0A2X0M1L3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g02425 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g02425</name>
        <name evidence="2" type="ORF">BQ5605_C003G02425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY40804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M1L3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY40804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="138" mass="15629" checksum="DC436CF51B9D0150" modified="2018-09-12" version="1">MLQSRTEVKRNGTCAPSISNRPNPSQRLNSSDYQRWLVLSDLLKRKHRETRLEAKANGPKVMPKVAQGRPKLGRLTGKCQNLDMRLGGETCVSSQNVNFCNVPRRFSGFWVLKMSKKKNAPPAGLSGVLAWRAFRRTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M1Q8</accession>
    <name>A0A2X0M1Q8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C002g01122 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C002g01122</name>
        <name evidence="7" type="ORF">BQ5605_C002G01122</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OB-RGRP/VPS55 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY30148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M1Q8"/>
    <dbReference type="STRING" id="796604.A0A2X0M1Q8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034424">
        <property type="term" value="C:Vps55/Vps68 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007262">
        <property type="entry name" value="Vps55/LEPROT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050">
        <property type="entry name" value="LEPTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050:SF0">
        <property type="entry name" value="RH04491P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04133">
        <property type="entry name" value="Vps55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY30148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="129" mass="13915" checksum="E21F107B3341B118" modified="2018-09-12" version="1">MTAGLKTIIFLSFVLAVSFLLVILSCALWANWLPLITALIFAFAPLPNALFSRFQSEDSFSAEYSSGPVDFGRFLTACFLVSGVAFPFALAHAGVIHEMAGWMSATGGAVGYATIITYSHFFAIQIAEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M290</accession>
    <name>A0A2X0M290_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C002g01291 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C002g01291</name>
        <name evidence="3" type="ORF">BQ5605_C002G01291</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY31963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M290"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY31963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="215" mass="24105" checksum="CC1DA63D298FE8AA" modified="2018-09-12" version="1">MADATGSHNIHGILTRRRTKRRPNPPSSPSIPSLDYLWRCTRDTGEQQMEGCVELRLWCTDDAKLFQRTTAGDLRDLTSFAGSPGDTIDETDDNTNEGVDFDMRDHSSDDLSHHSIDATDNGAFRLEEWDFNAEDDGIDDETWCRDPWGEFDGMLMGVDMYRTWFAGVHLILCLRGSIMATVLMASSPVLVSGLRLLSRKQQAIARMTGRDAGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M2A1</accession>
    <name>A0A2X0M2A1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C001g00090 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C001g00090</name>
        <name evidence="3" type="ORF">BQ5605_C001G00090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY43954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M2A1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY43954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="131" mass="15122" checksum="3B7CB4040C32E3C9" modified="2018-09-12" version="1">MAASVRTRTVPRNSSIEEGDTDRSFLPKVSRWMVDEDHRCILTLGVPDVLPPPSPFMYTGHDEELRMLRSPVQASNWFHLLPRSSSIRFHRRAPWPFHRRPSASISQLWISSFGLILLLSFDSLLFASTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M2U1</accession>
    <name>A0A2X0M2U1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="5">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C001g00283</name>
        <name evidence="11" type="ORF">BQ5605_C001G00283</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="5"/>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY45423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003840">
        <property type="entry name" value="DNA_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02689">
        <property type="entry name" value="Herpes_Helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="9">
        <location>
            <begin position="446"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="8">
        <location>
            <begin position="1105"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="10">
        <location>
            <begin position="1392"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication helicase" evidence="7">
        <location>
            <begin position="1487"/>
            <end position="1533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY45423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1576" mass="176487" checksum="B945E96A430D0D65" modified="2018-09-12" version="1">MYQHSVVSAAPACGVGAPIRSHVQALWDSGRAIATSPSLGREDSAVPWASSSARCWAPRGSTLLFVPHRSTEPAPARVMTTMQPILALRHVYEPAVQLCRTDSVVSAMANSTLGSPHHHLRKGECAGLESRSNPSSPTFSQGKLLQGSDSEAKAFRENARSYNNALSFTSLAAHWDQTQVGTLGPPVFHVFGRLYHRLDALIPAVNQRPAFAQTWLINPAEATDTRLEPDGADSHMQRSTLTKLESMLRTKNHFVREFASAKPRAGWDTAKEWILRLCLPPGRDRRTHNPPTSSMEMAMLICDSDTNTGDRGPQDLILQVNGDRCPDGRPKYQIVSSLHPSAMPLRYPLLFPAGEDGFHPNIPLCGVPPSQAANRQKLRADRQWFSNCARYLPVSVWMTKTNRRTMKMKMTRRTMRMVMANVFENLGRRSSKRGRGGSTRVSRSQYLAYHLHERDTYFSIPHATQRLFLEFVIDGYSQVETDRLNYIRFHQENLRLTTAQGITDAVANGLTSDQIGRSVILGSTFKNSPREVTQRYQDAMASVVKYGKPSLFITATCNPKWPEIKAALGPNDQATNRPDLIARVFQAKLNRLCDDVFGNKQRAGCFGVVLTHTHVIEYQNRGLPHAHILITLAPDDHPLSTEAIDKMISAEVPDPSRYPDLHETVTRHMLHGKCGGNSAQPCMEKDKYGNPRCKRHFPREQNPHTRMHPDGYPLYRRRFRHAVVKGGVIYNDGDCVPYSPYLSAKYNAHINVEAVTTIGAIKYLFKYVYKGPDRAVARVERAATGEGAHEEEPVRDEINEFVEGRYISAPEAVHRLFGFSTGRVWPPVNRLPVHLEHQQSVQINPDEPLPLDTPPTRSKLTGFFDLCAAAPDGELTATLLYTNVPRYYSWNKEKLRWKRRVRDRNVIGRIYTVSLRSGERFYLRLLLEVVMGPTSFSDLLKFEDAVYPSYRAACTARRLLADDGEHHICLGEAAQIKTGDQLRRLFVFMLIHATVANPPALLDRHFASLSDDARYHIERYEDVPINDQTIRLWTLNKIRLLLAANDQTLAFFDLPELTKDEVRLFDRLEERLPRFDRQQCLFDEFLRAVELDVVNQMRDNNLGPQHVFFLLAPGGTGKTFVENALLDTVRARGDQAIAVASSGVAALLLKGGHTAHSTFRIPLDTLPTSTCPVDRESDLALMLRTTKLIIWDEAPMAHRFAVEAVDRLLRDLRETEEHFGGVTTIFAGTPGQIVDASLIKADFWRDVRVLQLTENMRLSSNADAMDEAQLARTRDFAEWLLTVGDGTANMHPYDKIALPDYLLLPEGQRTAEGLINFVYPGLRTVNKESLEDLIQLFSRQAILAPHNATVDCINAKLLEEFNGDYIEYRSADEVVEAGETGGGMAPELISPEYLHSINPSNFPAHHLRLKEGIPVVLLRNLDPDAGLCNGTRLIVSHARSRVIQAIILTGDRAGTTVFIPRVRLETNATSSRQLGFTMRRLQFPLRVALAMTINKAQGQSLDRVGVDLSLHPVFTHGQLYVALSRAMSVDRIKVLLPSRDPADDDDDLQAVDRAAAAATATPNPVFRAVLRAMNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M2U8</accession>
    <name>A0A2X0M2U8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01562 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01562</name>
        <name evidence="2" type="ORF">BQ5605_C002G01562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY33860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M2U8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="1">
        <location>
            <begin position="288"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY33860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="665" mass="73836" checksum="35309EE8BBA66CE8" modified="2018-09-12" version="1">MTLPDAAAKLFDTTVTRLRSRPLDEEHHLDGAGGWTSWLSRIRGRLGKDIWDCTLAIPIKEPGPHVNLSLANEEVTKLILRSIKAKYNSMLITTAYDLTPAELLKSLEELVGSATLKDISIRLQLIFDVGVPPTSEAAFAIYIGQVTRLYEELSSFKLSFADVVSCRLLHFLKGPFPSYYVHAMDMQVDSIPNPRDILSECHALTGSETLPGAEAKSRPRRPRHPCRHCKGDHWNHDCPKRPKGVSSAKVALEVAPRPTPNASDLLGEDVQTLFTSRHSKLGGVSLIVLDSGATHHVVNTRSAFIEFVPCTSESRCIEGVRTAVMRAFDGTVCHLLNAIYVPGAPVSLFSVSRADKAGYSIVFGAGKCSITRHGVVCHTGAFINKLYCLNASLVDVRPSTLSVTRVVGCEIAVAGNNDWECVECLAANITHTTVEPSPKKSFSGAQHLSERVHVDLLAFDGHLSFRRRSLCPHHRRRSFSVVVGHTRIAPHSDAFRAFQEWLVQAERAISSGLPHYLWGQAVADLAYTRDPILHAALQHGLPYTLWYGRKPSVSRWHLRLYGCRAWKLATTEAPSSTEMRGLPFIFVGYDTDLKAYRRIAIRSKRPCRRIFNSLAPHRSPDPKDNTKYRSTFSSLIAYIFGLVPKMNGWRLARPPSSILPPQRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M2Z9</accession>
    <name>A0A2X0M2Z9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C002g01561 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C002g01561</name>
        <name evidence="7" type="ORF">BQ5605_C002G01561</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY33852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M2Z9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF86">
        <property type="entry name" value="ADR321CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="207"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="562"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="737"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="595"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="619"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="640"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="751"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY33852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="763" mass="82910" checksum="094EE8C63FCE4543" modified="2018-09-12" version="1">MTSLAHLLFLFRHRICQIVVGLLASFVQSLGLTIQRKSHLANEALPPHKRTRDAKRPLWLLGFLIFLTSNLFGTIFQLGALPIIVLGPLGAVSLLWNAFFARFILGDSFSIHIVAGIILIAGGACLIAIFGVVPEQTHTLPELVALYTRTPFLVWATLLSIALVSTLTLAHLAEWALERRIASKYPDAPPLTPKSIRTSSELRRFTRRASLEGSPRRRDAFARKGSARQLHGSVGSLNDSSGGLGSGRMRLDLRNVTFKDRTVGRTDAEEVHRIVLDGSALDDEDPRSPGVQHDQGNTEPIFSRRRIPGPTVTITPPELDFKDAACLADVEAAIERSRLILGVAYGAASGTLSGLCLLFAKTGIELLIQTIVVRQNQFGHFEAWAIVAILAVAAVCQLFYLNRALRLVGPTLICPLAFCFYNLSSIITGLIYYDQWDQLTSLQFGLVALGTAILLGGVWIVSIRSEDEGQEVEEEGMGNPYQPLFLDEPGCYHSDLEEGRLVDDDEVEVDEDDEADSETEDDFLDLDEDAIPSPLALPVEWIPRGLTIGLGAASPGFDLRPATRRASQSVHLGGSGGGGLYAHRRKTSLPTTPFNERESNRQGGERSNATAEPGIDGQPTPTTNGRSSSSTPNSPRRRATNSSNAGTTMTRSERAMSLSGNLYVGRCGNFEDAHSAYHQHHRHSSFATAAVAAQAWHRVGSGAGMASPTTTTMTSATMPSGMGATDEEETLIIPQVSTSTISTGEVEDQKKKKKKKKKWWRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M307</accession>
    <name>A0A2X0M307_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">[acyl-carrier-protein] S-malonyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C002g01571</name>
        <name evidence="6" type="ORF">BQ5605_C002G01571</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>holo-[ACP] + malonyl-CoA = malonyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.1.39" evidence="1"/>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY33941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M307"/>
    <dbReference type="STRING" id="796604.A0A2X0M307"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050858">
        <property type="entry name" value="Mal-CoA-ACP_Trans/PKS_FabD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42681">
        <property type="entry name" value="MALONYL-COA-ACYL CARRIER PROTEIN TRANSACYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42681:SF1">
        <property type="entry name" value="MALONYL-COA-ACYL CARRIER PROTEIN TRANSACYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="5">
        <location>
            <begin position="5"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY33941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="246" mass="26709" checksum="B26D6F261C6D6891" modified="2018-09-12" version="1">MQKRLHGMLTTHALSLPSINLSTSFDTPAARIPQMSAVVLNPGHSHDEVVQVVRKIRAEDNVGPQHDRGCAGTVEVASFNSSAQIVLSGSREGIMRASEFLREQGIASRAADLPVSTPFHCSFLEPAAEGMRVALEATHLNNPLIPLVSNLDGTMINTTHSLVSNLVAQISLPVRWSKCLRNLAQDRIDRLVFLGPGKALANLARRDATLREKHSGQPSRTEVLSVATDADLEAFAELWKEETAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M316</accession>
    <name>A0A2X0M316_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C001g00310 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C001g00310</name>
        <name evidence="1" type="ORF">BQ5605_C001G00310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY45625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M316"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY45625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="239" mass="26609" checksum="ACF5FF9AC4134BF0" modified="2018-09-12" version="1">MTYCEIAAETALTDFVWGGPRRNTVAREFVFQAREDGGLGLISIGDIVHSVALRFWDAVAGSDEAIWAPLARESWRSLVAATRDFSPWGFFSSTPRVEKLYRDSTRWGAVVAAARVTLPTIKSELLTLPELLSLPPRLPLLYAEGAKHAYDDADAVAKFAQIADLYWRDEGKGWALVGHRRGFWQHSKEPALQHEHVWSRVGQLLKAKALLPKTAVRPARIPLKEDPHVSQCTTCPLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M394</accession>
    <name>A0A2X0M394_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C002g01460 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C002g01460</name>
        <name evidence="6" type="ORF">BQ5605_C002G01460</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC15 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY33173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M394"/>
    <dbReference type="STRING" id="796604.A0A2X0M394"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006973">
        <property type="entry name" value="Cwf_Cwc_15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12718">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12718:SF2">
        <property type="entry name" value="SPLICEOSOME-ASSOCIATED PROTEIN CWC15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04889">
        <property type="entry name" value="Cwf_Cwc_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="61"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="137"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="171"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY33173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="283" mass="32478" checksum="78B74EAFCFDAA036" modified="2018-09-12" version="1">MSTAHRPTWDPAQGKDSRLNSRVYSSRDLAAHTRLKFRQPGQGNQTDVARRDLKLELLAAERESSDRKAKGQSGYVPDRPLLLLENQTQQQHQTDETNKRRTFLADLAKLDRDDDDDDDDDEEERPKDKGKGKAVEDNDEQDDDDDDDDDDDDDDDEESDSDDDDEDETAELLRELEKIKRERAEEKERLERERAANESTTREEEIAVGNPLLNLQAALGASPTPSAMSTSTSASTFGVKRRWDDDLIFKNQARDTNETPKAEFVNDLLRTNYHRRFMKRHVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M467</accession>
    <name>A0A2X0M467_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="21">BQ5605_C001g00740 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">BQ5605_C001g00740</name>
        <name evidence="21" type="ORF">BQ5605_C001G00740</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Single-pass type III membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the OST4 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 16">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY49124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M467"/>
    <dbReference type="STRING" id="796604.A0A2X0M467"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000024">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018943">
        <property type="entry name" value="Oligosaccaryltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036330">
        <property type="entry name" value="Ost4p_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF30">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE ISOZYME 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10215">
        <property type="entry name" value="Ost4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103464">
        <property type="entry name" value="Oligosaccharyltransferase subunit ost4p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="13 16" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="664"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="20">
        <location>
            <begin position="14"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="18">
        <location>
            <begin position="259"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="19">
        <location>
            <begin position="456"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="SGY49124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="698" mass="76771" checksum="8C5C9C0215623550" modified="2018-09-12" version="1">MASPQKLDKGKIYLGSYLLERLAQLDVRAIQGVPGDFNLAFLDLVEDHKQLEWIGCCNELNSAYAADGYARVKQSQASYSGKGTSRKTTGGVKGFAAVITTFGVGELSAMNGIAGAYSERVPLLHIVDLGAHTPTIIVIAGVPSTKAQKEKFLLHHTLGDGRYNAFERAAESITAAQAFLQSTEGACDEIDQVIRIAFETARPTYLTLPTDLVFSPVDASRLETPVIPDGFSTEDKAMLPSGEKIDDSKMKVVDFVTKEITRLWDAAKNPTILIDACAIRYGVTHLVRDLVEATQVKYYTTPMGKSALDEDPSKGFAGVYVGEITCESVKEAFEKTDLKIFVGALQSDFNSGEFSQVIGEEEKVELHSDRVSVQYANYPTVSFHTILPALAKSLKPKKVEETDASAGQAFKIPDSPVNEMVTQAAFWPMWGKFLQENDIILTETGTSAFGFLDVPLPKGATYISQTLYGSIGWAGGALLGACLAAREAGFPRRTLLFIGDGSLQLTVQDISTMLRHDLKPIIILLDNDGYVIERKIHGENRVYNDIATWKWQEMLSFFNGNNIPTRSYLAKTRGELESILADDQFAKADVFQLLQVKMDRQDAPAALVRQAKLSEKLNSGRNRNVYYNNVSTLQLELSFPCPNQFGPLDCLHSKRRSPISDTSLTSLANTLGIVAVLLIVVFQFVEVNAKRENERERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-05-29" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M4E2</accession>
    <name>A0A2X0M4E2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C003g01902 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C003g01902</name>
        <name evidence="8" type="ORF">BQ5605_C003G01902</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY37857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M4E2"/>
    <dbReference type="STRING" id="796604.A0A2X0M4E2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF20">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="43"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY37857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="469" mass="51857" checksum="A82801D76D0E1821" modified="2018-09-12" version="1">MSLTPTSSKEELERKQKIEQQQATVITDDGASVVESQAIRERKLTWVEATLLLLTEYVVLAILAFPSSYLVLGMAGGVLSTLIIGVSTYYTSHVLWRYCLKHPEIRDICARFAAFVGLALNNWAIMGLHVNAGATAIQSIRGGTETTLFWACMMGLIMLIPSYIREFKHMSYLGTLAAFTMFICVIITIAGHGVQPHPNYWPSLGTDVTYTVWAPKGTSFIQGMNALLNIVYTWIGHALIPSFVGDMERPEDFPKALAVSMLSEFILFTLTGALVYFYAGQYSTAPGYGSLIAKYGKAAAGFTLPTIVIVGVLYSLVTSKAVFYQIFREGSRHRTQHTVLGWSAWFAVVTAGWIIAFIIGQAIPFFNDLLALISSLFDSWFGYILWALCWFQLYRGRYTETTGRKIEFVVNIVILITGIYFFGAGTYASVQSIINSYHAGAVKTPFTKVDTGFTFPSPSSYNATSGKFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M5T3</accession>
    <name>A0A2X0M5T3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g04049 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g04049</name>
        <name evidence="1" type="ORF">BQ5605_C006G04049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY55595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M5T3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY55595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="119" mass="12932" checksum="F8DEDEE144890AC3" modified="2018-09-12" version="1">MPSANHDKLQSAILSAGHKGQGHRVFARDKIYWPPGTLPVPGGKQLEYVVGTERLCYYEVIDASAPSCHYIDAEFTRPSIDNSAEKALITRNAASYLPGTYGQLASSDTLRSCVCSVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M6T8</accession>
    <name>A0A2X0M6T8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00459 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00459</name>
        <name evidence="2" type="ORF">BQ5605_C001G00459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY46668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M6T8"/>
    <dbReference type="STRING" id="796604.A0A2X0M6T8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY46668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="404" mass="44644" checksum="C03B54145EFE42E0" modified="2018-09-12" version="1">MPMFRAQEPLLPFTSTPPDQTHPLYPTAPQESLLPLSASLKPARYNRRATRRHYVEVDSDEEDGESTRNYGGDYDEYGDVGRGRHMADAQSQRSTTAKSSSSATIVGDTPKRTKRICIAVGDLHPLQEGPSTELAEQHTPRLCSPRLTDLLSAYSATPNPDECRTQSSNPNKAGRKCSEGRPCDRCRQRGYTDCRDAPRLRQTGSNAESNLKATKVMKPEIRSGGGQDYSALDPQIVSLSPCRSRSFFLPSPDPPVVRHPSKPRSPYSALDTQTPPSFTPPPSPTPLHFPSPRYIIPNTLPHLDYPLKPLPSPHLPPLLGCPPLITPTNRLSPPHKSTYPNSRSYKPTLNLPSIRSLFFLGEDDVDRWKKRLLDESSLAATGVGMGQARFRTSFERTSAKGVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M7F5</accession>
    <name>A0A2X0M7F5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C007g04617 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C007g04617</name>
        <name evidence="2" type="ORF">BQ5605_C007G04617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY61876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M7F5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="373"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY61876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="397" mass="44080" checksum="DECE29EEB7315B92" modified="2018-09-12" version="1">MLELLLPFTGVRERRREPIRVSVPVRSHDLGWGLGLAKYHWVVPKLEPLRDSMRTPPVTILPDELLHRIFCFVQSEPLSTAPLPSSRRAGSLSTAPSAPATSLGNAISFQLARIRASLECLRNQNGQAERISQRMDQMGLYGLSTDRSSPELMASRARVAALRSFSLVHRRWTPIAQRLLFSSVAITHELQAKEMFHSLTPRTHRFQSLSITGVSNGAVEALLSRVQAVAQLRLALVQESHNAVGFQGSMLLSPGLKDLDTLVLGDPFRFTDWPDSWPTHLRRLSITSSAFFDSSEQGHSRPVTRHLPPTLSELHFRMRGADQLPHQLHLLIEALPSNSFLLTMTRPTNSTKNPTPTIHSKRLVGSTTLHKQSPTSFSPLSSLPRSNTSAFNSSSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M7P0</accession>
    <name>A0A2X0M7P0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C007g04717 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C007g04717</name>
        <name evidence="10" type="ORF">BQ5605_C007G04717</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the arsA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY62650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M7P0"/>
    <dbReference type="STRING" id="796604.A0A2X0M7P0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02035">
        <property type="entry name" value="ArsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000235">
        <property type="entry name" value="ATPase ASNA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03112">
        <property type="entry name" value="Asna1_Get3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="ArsA/GET3_ATPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027542">
        <property type="entry name" value="ATPase_ArsA/GET3_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00345">
        <property type="entry name" value="GET3_arsA_TRC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="ARSENICAL PUMP-DRIVING ATPASE ARSENITE-TRANSLOCATING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803:SF3">
        <property type="entry name" value="ATPASE GET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ArsA/GET3 Anion-transporting ATPase-like" evidence="9">
        <location>
            <begin position="57"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="64"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY62650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="364" mass="40242" checksum="1FD841DC0DF469BB" modified="2018-09-12" version="1">MTYICAEPEGDALPANLQNIIDQESLNQPELLAWPVGTALAAQTFADLDRSVLDVARWIFVGGKGGVGKTTTSCSLAIQLAQHRESVLLISTDPAHNLSDAFSQKFGKEATRVNGFTNLSAMEIDPSASMQDMVEAGETDSSGMQGMMQDLAFAIPGIDEAMGFAEVMKHVKSMEFSVIVFDTAPTGHTLRFLSFPSVLEKALAKLSTLSGRFGPMLNQVSSMMGAGVNTGEMFEKLESMRLVVTEVNQQFKNPDLTTFVPVMISEFLSLYETERLIQELTTYQIDVHAIVVNQLLWPDAGSTCKHCNIRWKQQQKYLKEAYELYGEDFHIVKMPLLSEEVRGTDSLKQFSNMLITPYVPTNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M7V0</accession>
    <name>A0A2X0M7V0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C007g04720 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C007g04720</name>
        <name evidence="9" type="ORF">BQ5605_C007G04720</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DOCK family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY62674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0M7V0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08679">
        <property type="entry name" value="C2_DOCK180_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11684">
        <property type="entry name" value="DHR2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.350">
        <property type="entry name" value="Dedicator of cytokinesis N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043162">
        <property type="entry name" value="DOCK_C_lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032376">
        <property type="entry name" value="DOCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042455">
        <property type="entry name" value="DOCK_N_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046769">
        <property type="entry name" value="DOCKER_Lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046770">
        <property type="entry name" value="DOCKER_Lobe_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046773">
        <property type="entry name" value="DOCKER_Lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056372">
        <property type="entry name" value="TPR_DOCK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653:SF10">
        <property type="entry name" value="MYOBLAST CITY, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06920">
        <property type="entry name" value="DHR-2_Lobe_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20422">
        <property type="entry name" value="DHR-2_Lobe_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20421">
        <property type="entry name" value="DHR-2_Lobe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16172">
        <property type="entry name" value="DOCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23554">
        <property type="entry name" value="TPR_DOCK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 DOCK-type" evidence="7">
        <location>
            <begin position="818"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="domain" description="DOCKER" evidence="8">
        <location>
            <begin position="1756"/>
            <end position="2205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="241"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="494"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1421"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2216"/>
            <end position="2247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2271"/>
            <end position="2305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2338"/>
            <end position="2384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2396"/>
            <end position="2440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1421"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2222"/>
            <end position="2247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2273"/>
            <end position="2291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2343"/>
            <end position="2355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2363"/>
            <end position="2375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2429"/>
            <end position="2440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY62674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2440" mass="268092" checksum="E904675D62F2C786" modified="2018-09-12" version="1">MERSKLKSKLKPHARASLTSGRLASSLGQPTHTRTSKTIHRPTTGPPRDFVSGFYATALTVPKKDMEMRGRWLPAQQVSFGCVTSSFEPLASAEGKGEAGGSLVADGASGRTNGVAVAPHEQVSEEAQGRGRGERGVLNPHQVALEVGDEVYVFEVFKPDDADDPVWYRGYAVSTSPRPRLPTSISLDQQAFPSMTAASPGLSLTEEPQAHVILPALSDVSCATVSVGIFPASHVQIRDSIDSSEHSEPTQRIAADAASASANGEGAPRPPTHRDLMAGRMEPLQEENEDEASDEVGTFVTSTREQSRQKNRASVISISSFVGSLATELQTSFKQSRSLQSPDGFLGRMFDPRPAPPLPNLKCGDETASGFEEPLIDEIACALREWASLLYTHLYRRDYALFDSVKQHIEVLHSGRKQLLAKGLSRAETDKLRRELVSRLVQGNVEQGLDVIVRHPQYGGFVDVGVEGDVERKAWVSVVKMYAMQVALAYSGADPKSSTASVLPPTAPALSDEPSSSPITSNTSRFAEPNLFQMTPDKTQAAAPAVPPKPLAKFHHVFVDVRSFNASPCLPGELVELYFALFNKTDSRYITEEWCVVLNHLGQHVNDAESKQGRMRTLFLDLSQSDVQDQLFLVCRIVKNASNKNTHGSPELGSTLTLGGSLRRPSFFPTPGSPQLTTTDDASTIPGFSMSATDLSLAEHGGMLLSDASGRQTSRRPFGCAVLEISQFAKASETSVEHSMPIFVPIHESNFSLLHEDIIASRIKEIERSPCAESLSVNVRILYGEANALRKSMPQLLDGVPLTNRLGFPDVVFPGDQRNEIYLKIWNGTFSSVSGMTGTTRGLAQLTAVAGGGAKNIEVTAEVRTRDGRAVERAISRGAGEPNVTQFQSITYKSNNSPTWAELLKLEIPVELMESCHVFFTVRSRGSKERGPPGAPPTERPFAFGYMPLLLNNSAFQSDGSHVLMMYKYDVNAAIPSVYLKAPSLRMADSKEALEALPAYTNKTLVLLKDTLTVRSFLVSTTYTQNETLLKLLRWETELMQDSEALKDTLTKLRFCSEVEVCKFLRPIFDALFGILARHPTGDVDDFVFHALVTILGFVSDRRFHNFRPVLNVYIDQHFSNSSASSHIISSLHKLLRDPSSPEAGTTLRASIKVWHYLFKFVVTSREIQRAKDVGSGVTSDHLEMTFKRDLSALLTQINFLMRMSTPSSIIGTQTLAVQHFASILPDLAKCFDPQELADLAISFCDSVTPKGKIAIWKILLQSQLVNGVLFTPSVGRAALVPNLVRWLKSALGKFDEHAMCSPKDTEAMRDNARVAWVEGIRLANGVVAAMLDSIHTALVSHEVQASRGQLAQEQDNIEYLLALVPKLLESYRELENIANLESIARQRSTASVIAAVPTVFPSSYPFSLIALPPNHLHREKARQRARARSHVPDAQSEEDEGTPVSLQGGVGEVACVFIAILHLAPCKIFTNWLESISEVESKDKFGQMLAQIFRVSKSILSDDGASAAFPSEWLSISILAHQVIVKILDPIADILERDFVPASSASYTFNTSLWRDFFSMLLRLLGSPQLLIEDFSPQKRRAVWRLAGDLRGEGAKVLGRLWNAIGGPEQRSTVRTGGYQVQFVPGLVGDVLTLCLSHHDELRKTAVQVLFSMIVSEYSLNDDFRAIEAEVIDRLDKLFMSQTKNHEISRAFFVSQLKTLFDEAKIETKLREQVETFIASVNSFLDLLLAVRNLPDGEEYQEDRIISTLKLMSFIRGIGRSEIFVRYVDRLVSYHIALGNETEAGLTLMLHADLHTWDLKTYVDALPDLGFPRQTAFARKECVQITSFCEIKTPQLTAPPPPHRSLYMRILEHMTKGKAWETALALCKELQQQYEMQNFNYARLSELLILQSELYASIIKGDRQFGDFFRVAFYGNRFPSSVSGKQFIYRAAPNERLETFTERMLNKHPNATLLKSSMIPPDDVQYSDGQLLQITAVTPEPDATTPMLTNPDVPPSIKAYYQQNETHMFSFSRPFIREGGDKASAESEFMNEWVEKTVLICEDSFPTVLRRSEVVEIRIIEISPIEMAIADVESQRQGLNELQQQYTTLGLQDASYGSASLERINTQPLSLALNAAVDPPPQQGVPMYRRAFFGVEYAVMNPGKTSLIQKLQEEIDQLVLVIGRCLKLHAVLCSPDTGPFHATLEDLYAKTFANELSRLPEETFDATEFAILESDGAAPNPMSSSRFPTRANGGSSSRIMGGSNTQPVLRTQGSVLVSTGKEPTIARADAATPTSTLGGSSRSNSVSTLTPLKGRESTSTTVAVGVHGSPSYAVYSMTSGPSSLQRTESMLSIATTATTTTHRGPNASTTTLDSLQARRPSSPATFSISSNSTATKRKPSLAGDGLSKQRLANLAAPFNGKNGGGLRSKDTGGRNSVFGNLWKKKGSTLPTGQEFSDQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M8X6</accession>
    <name>A0A2X0M8X6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C001g00898 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C001g00898</name>
        <name evidence="1" type="ORF">BQ5605_C001G00898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY50574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M8X6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY50574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="93" mass="10133" checksum="19BAA7E75DFE1496" modified="2018-09-12" version="1">MLELWRKGWFARQAWNSSVVSLSAKLRGSQGSSTSSVLALREDLCWNGLAQQKTISSVSTVGANWVEAVIASESEARDSWAQYSLESVQLGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M9M6</accession>
    <name>A0A2X0M9M6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tethering factor for nuclear proteasome STS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C004g03033</name>
        <name evidence="5" type="ORF">BQ5605_C004G03033</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Binds the proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the cut8/STS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY69579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M9M6"/>
    <dbReference type="STRING" id="796604.A0A2X0M9M6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071630">
        <property type="term" value="P:nuclear protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031144">
        <property type="term" value="P:proteasome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1590">
        <property type="entry name" value="Tethering factor for nuclear proteasome Cut8/Sts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013868">
        <property type="entry name" value="Cut8/Sts1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038422">
        <property type="entry name" value="Cut8/Sts1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28032">
        <property type="entry name" value="FI02826P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28032:SF1">
        <property type="entry name" value="FI02826P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08559">
        <property type="entry name" value="Cut8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="82"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="82"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU368013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY69579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="464" mass="49387" checksum="C1985AB26C7DB089" modified="2018-09-12" version="1">MSMQVEPPSPVHQQPHQHQHHHHHHHSMNPPSSWVVSAAAPSLSSSPSSSANASSHVVPFGAIPGSQPGALSFGFGLSAASHMSSHSQQQPPATATGGWGHAASASASAAWGQAPTTQHQQQQAALRSNNPAPTPASPAVAVSSRRRRRRSLSMDDDEAQDASMDQHIRSSPRTIAAAPPFSTRGIKKARVASTSIAQATTGPTTADLGKALASLSKESLLSLLNQLVSTSPQLVPTIEALLPPPTLSHSIEMIHHLERAVVAALPGGQNLRDEYVFGRVRVPLEQFVAESKSFLASFCSPTPRVSSTSTSSDDEIGHPSTTFAFLFALTSSLRRLELALPSTRSQVLSTTSDPMNPIASHLLPLTVNQWHVWLTRLSTGVNHEGRMLAATTLRTWFSKLEELCVDSPGVGLVGGRGEGVAKRAMEGVRERLRKEVGWVIGWREGVGAGMEADGRGIETEEEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MAB7</accession>
    <name>A0A2X0MAB7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g04173 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g04173</name>
        <name evidence="1" type="ORF">BQ5605_C006G04173</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY56796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MAB7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY56796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="55" mass="6044" checksum="7F95AA6EB61D8CD4" modified="2018-09-12" version="1">MASACTAGIVHRDMNTAMRQLVTEEQTNWPKVVPFVEFAINSGRSSAFGISPLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MBH0</accession>
    <name>A0A2X0MBH0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C005g03632 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C005g03632</name>
        <name evidence="1" type="ORF">BQ5605_C005G03632</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MBH0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY77421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="54" mass="6485" checksum="4D3244266F8DFD30" modified="2018-09-12" version="1">MMTHARPQSEHTRPLVRLYQLFKIQPDHLSDFRFMLSRIHCGAGFQEVVPYELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-11-27" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MCJ3</accession>
    <name>A0A2X0MCJ3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C008g05276 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C008g05276</name>
        <name evidence="3" type="ORF">BQ5605_C008G05276</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MCJ3"/>
    <dbReference type="STRING" id="796604.A0A2X0MCJ3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF4">
        <property type="entry name" value="CYCLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015873088" evidence="2">
        <location>
            <begin position="21"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY79994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="404" mass="43589" checksum="E30B8D2E8CDCB30C" modified="2018-09-12" version="1">MAPHHFLVGTFSTPVVFTLAFDDADGSLRVAGQSKATGAHSWLSLNADLTRLYATAWTTPPGLASYRVVRNETHVPVLEHINSVETKARSGYCCNSSIAVYSAGGPTGEVFKIDPETGGFDSSTKRPLQALNFVDAKGQQDDGGVMDFGGLRHGAHSADLSLDGKRLYIADIGRNCIFVYSVQDDGKLVLTDKNIAPRPTDGPRHVTPHPNGHCVYSLQEHTSMVDVFEVSATKWNIHPYTHALLTPFIDTSVQVSDQEKLDWKDGVKIIPKDLSPTLFWADEVRLSPSNSSSTPSYLYASTRGLEPSTLGYVAVFKLLPSGLFASPEPLAMLQTPTSGGWANAIEPAPWASTSEGAEGKDYLALTDSEEGLVMVLSWNGEELKEVARVQLDGKAPAATAVWID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MCL8</accession>
    <name>A0A2X0MCL8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BQ5605_C008g05173 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C008g05173</name>
        <name evidence="12" type="ORF">BQ5605_C008G05173</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MCL8"/>
    <dbReference type="STRING" id="796604.A0A2X0MCL8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20513">
        <property type="entry name" value="CYCLIN_CCNC_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20514">
        <property type="entry name" value="CYCLIN_CCNC_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000076">
        <property type="entry name" value="RNA polymerase II holoenzyme cyclin-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028758">
        <property type="entry name" value="Cyclin, C/H/G types"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 9" id="KW-0195">Cyclin</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Cyclin-like" evidence="11">
        <location>
            <begin position="61"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="244"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="335"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="335"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY79602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="402" mass="43634" checksum="00FC6F7B27996DD2" modified="2018-09-12" version="1">MAANFYLSSHANYHLHPRSALLAARVDDLRHATEQEIAWVEIWSGSGESSCFDIGYTSQALVIQKLCKRLGLRQQVIATAIVYFRRFYLRNAYCDTDCALVAAACCYVAAKAEETPVHVKSAVAEAKMVFHDMGLAFPSDNTKLAEMEFYLIEELDFHLIVFHPYRSLVQLCGRDGGPSAGGEQGRLNRQAMLEMDEPALQMAWFIINDTFRSSLCLVHPPHLIALAAIYLAFSLHPPSSVVKETASTNLKDPSISGPASRTRRRSTDVAPSAAPRAHATTSSTVATTVPTVGGRTDAITFLASLQVDHSLILEIVQDVISLYELWNQLEASAQATSPSSTGSQGGPSAAPVSRISIGGGAGRTTSVSADEKVVIILARMMKDRHRELQSEKGGRGATGWKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-11-27" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MDA0</accession>
    <name>A0A2X0MDA0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C004g02907 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C004g02907</name>
        <name evidence="1" type="ORF">BQ5605_C004G02907</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY68647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MDA0"/>
    <dbReference type="STRING" id="796604.A0A2X0MDA0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY68647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="463" mass="51503" checksum="16B67788BDE6A7FB" modified="2018-09-12" version="1">MPSFTSRLPTNPNPSSLPKYYGDASTLLSLDKYNRRHAFRPSWISDDEPDHTVSYACVGAEKEDELETVVWINGLGGNRFAAGQLFVTLMSDRLVGNLPSPLLHRVHVRTYCALQHGLFTMYRLRLIHIDRPGAGHSTPVPLSHRVEWSTEALLSILSHEGTTPHLSLISHSNGLIYTLHLLSHLPRTYTLRHWFISSPFVIPFLSGSWSLGLASYLPAPVTGSLGTLALTFSTSLGWYHSARGVSSGGLGGLSKWWGGVPLTSTTVAAEAEDPTLSTEEESTQVTKKSRRHYELFVRKQNDLYASADDARQNEHRKTFEGYFFGPDLFNEVMKRAGKEGLGYMGDEALISLRKGEEARWGWPKEGEEGQDGSVYLRGFREWKEGWKKEGRALPRIKVGYGSEDGMIPKRGRDHLKSVLVDQLGLVKRKDWREIGGAGHDDTLGVTTLTEPWCQSVVASAEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MDQ1</accession>
    <name>A0A2X0MDQ1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C012g06877 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C012g06877</name>
        <name evidence="1" type="ORF">BQ5605_C012G06877</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MDQ1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY16458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="230" mass="26910" checksum="46DBB4BDA9D24A2D" modified="2018-09-12" version="1">MRLKNARYINYSDEDRLPRDYLTPFRRFLSSPRFPYQSLTSLNLAFSPLKLPFLRSLLLSPRSIPLFPHLSHLNLAATPNLYFVEAFFKLLSSLISLRFLSLAGKSLYPPLHLEEEEEKEAEEDALTRAHLEGFFNRLASAPRFLPRLVEATPTLQSLDLSYIPDLNINALHSIAWDRQWLDLVKLGMRNYAARTTSIELERGRRLNELGFVVKRRGEKTRKRLWLDVYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MDS6</accession>
    <name>A0A2X0MDS6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E3 ubiquitin ligase complex SCF subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C012g06897</name>
        <name evidence="6" type="ORF">BQ5605_C012G06897</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SKP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MDS6"/>
    <dbReference type="STRING" id="796604.A0A2X0MDS6"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18322">
        <property type="entry name" value="BTB_POZ_SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000026">
        <property type="entry name" value="E3 ubiquitin ligase complex SCF subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028729">
        <property type="entry name" value="E3_ubiquit_lig_SCF_Skp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="5">
        <location>
            <begin position="28"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component dimerisation" evidence="4">
        <location>
            <begin position="130"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR028729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY16532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="180" mass="20629" checksum="B68E4656445F967C" modified="2018-09-12" version="1">MSTGQITLSTSGRTTPHPLALVLYASHSSDNETFKVEKDVANRSVLIKNMIEDLGETDHPIPLPNVSSNVLKKVLEWCEHHKKDIDPPAEENDDTRRKMTEISDWDQKFIQVDQEMLFEIILAANYLDIKPLLDVGCKTVANMIKGKQPEEIRKLFNIVNDFTPEEEAQIKKENEWAEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0ME10</accession>
    <name>A0A2X0ME10_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="23">BQ5605_C138g13412 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">BQ5605_C138g13412</name>
        <name evidence="23" type="ORF">BQ5605_C138G13412</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 25">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000050">
        <property type="protein sequence ID" value="SGY88342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0ME10"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
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        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="14" id="KW-0229">DNA integration</keyword>
    <keyword evidence="18" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="16" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="15" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="16" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="17" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="22">
        <location>
            <begin position="387"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="668"/>
            <end position="764"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022695"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022842"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="SGY88342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="835" mass="91222" checksum="E3C947AB7887F554" modified="2018-09-12" version="1">MVLHVDDFAIKTVLMEQLPEKYTFAFREEKDVDLFLEKVRTAYDEDVIMNGANDKEQTEAPASALAAARQEADPGQAPPCNGNCACGQQPHAFATAGHGRTGTRVGAKTRAEHYANSDKWGKIVGGKFMCANNQCVNCFGFGHRRAACDSRNPTGDRIAFLQSLDINVPVASHGTYFVEDPVPMSLANRMGASFHFTNYAAEVREQTIFRAVTAEAPELIFDTGATTSLVNDKCMLSDYATLDCPIFMIDAAGTRTPAVGRGTLTAEFALADGTTSKMTIADVLHVPNFGVRIEMEEGRCEFSKDGQTFAIAQLIGSKYIFQARLSNLNPTEAQSLTVSVRSNSADREIWHQRFGHLNMPYLLEMERKETVMGLNIKGEDFDVAKCHGCMQGRGVHANILERASPAEVMVLGLVDDYSRFRWSFPIGKKSSVTAFVVKFIQRVERSRDCNVAIFHSDNGGEFVNNSLKAFFRERGIEHRTTVPYAHYQNGVIERGWRTMFKTVRIWLLVSGLPLSFWAFAATAFTYVSNRRPTAALPGSTPFEMYHLRKTQCLAFSRMGLRGARFIGYAEQGWMFWRPDTNTVFDSPTTLFGDPPTGSLDIDGNDAVEQDFSLDGAGRAQAPGTDDRATAPIAARRAFAPDGDSRDNTPPVGRARLLILTPIVPTRRAPAPVVSNGRAPAPVAPNGRAPAPVVPNGRAPAPVAGDGGAPPPVASRRPSPFLDDDADNDPPDPNPIPDGYEPVVPTTERTSELAERWGAPAGSRRRGGAEQQAIMEQVLSVVVNLEECNGWTNLSSIVQGSTEGICGIEELEAYQVWTGNPDEPTYKQAVRQTAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MFM7</accession>
    <name>A0A2X0MFM7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C036g11518 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C036g11518</name>
        <name evidence="2" type="ORF">BQ5605_C036G11518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000063">
        <property type="protein sequence ID" value="SGY95819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MFM7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015867557" evidence="1">
        <location>
            <begin position="23"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY95819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="58" mass="6361" checksum="F0A7CDDE0E49D3F3" modified="2018-09-12" version="1">MHVPFLGLHCVVDVSLPASAAAFTTCRDRCIPHSQNYLPADEVADRELHLAGRSQLQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MG26</accession>
    <name>A0A2X0MG26_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phospholipase D1</fullName>
            <ecNumber evidence="3">3.1.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Choline phosphatase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Phosphatidylcholine-hydrolyzing phospholipase D1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C008g05292</name>
        <name evidence="13" type="ORF">BQ5605_C008G05292</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phospholipase D family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="3"/>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY80044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MG26"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01254">
        <property type="entry name" value="PH_PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09138">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000011">
        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF76">
        <property type="entry name" value="PHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="12">
        <location>
            <begin position="886"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="12">
        <location>
            <begin position="1200"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="667"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1288"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1412"/>
            <end position="1610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1694"/>
            <end position="1796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="250"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="337"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1412"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1455"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1492"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1536"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1572"/>
            <end position="1599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1703"/>
            <end position="1713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1716"/>
            <end position="1729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1734"/>
            <end position="1750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1753"/>
            <end position="1768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1775"/>
            <end position="1796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00079280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGY80044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1844" mass="203202" checksum="7EDB9A9563077043" modified="2018-09-12" version="1">MDFAHIVKQAREQQKSHGFKSPHHLSLNSNQSDHHYDEGVTPGSTPASPGFNGARFRSSHSPANAETSLARPISRGAGAGAPSTPGSGTQPASTPTPTPTRPRHRSQASFDWFADLPPNSSSGTGFPTLGQQTSSRNPSSRNPSFSKRDSRWNPSTSNGHACVSDSPRELSEAEEEDENQDNGNRKKKSLKSGSLESSIPPKDEEPPGKGKRSSRDLGKSSQSDQSEFRGAFTEEDMTRGARALKRRSGSESAASGPRRNSTMNSQHDEARDRFQELPEESSPHTAGTVPDKGKDQPGSSSTGAAPPPLGGRKQSLWQGAAELFGVSSGSGPAPAEAEAEEADNEELDGDPEARKAKVSQGARKSSAWGVVKKKLGGETKQPKQKAGATLTGHELIAELTTGILPMVIVKMAVMDRDERGEHRIPILMNYLKLRITDSVYPFHDRHAVFRCELEYGDAAVKWVIYRELKDFINLHAHYRVANLRQGIEKFPTFPKTSIPYLNWLKSERGGSIAKADFAKAQRKALEDYLLKLIRATMFGPGANRLCKFLEISAMSLSLATRGGEQGKQGYLTIASSGASRRKAPGFHPLAFSNRHQPKWFIVRDSFIVAVDDPASTEIYDVIMVDSTFELERPKRILRQGLNAITFNSDSSEEADGHQDDIVASEKKPMGYRGAGDPNDPSTTGAGSDLNKLKETSNHTFYLRTSERKLRLIAKTERQQDQFIASIEKMLAKTIWAGKNRFDSFAPIRLNASAQWLIDGRDYFWSLSRAILLAKHRIYIHDWWLSPELYMRRPAAENEQWRLDRLLQKKAEEGVQIFVVSYRSMGNDALLRSYSDAPSLLLHQIVYKEVSNDFTPVESNYTKSRLRGLHPNVHIQRSPSHTSTGTLLWSHHEKMCVIDETIGFMGGLDLCFGRWDTPGHVLTDEQPNVVFDPELSKSADAEARAGSQIWPGKDYSNSRVLDFHTLTKPEEDMYDRGKVPRQPWHDIGLQIIGQPARDLCRHFIQRWNYLLRTKNHTVKMPFLLPAPDFTPKELHDQRITGTCEVQICRSVGPWSMGISHVEHSIQNAYIKAIQLSDHFVYIENQFFITSTEVESTIIENRIGDALVSRILRAHSEGTAWRAIIIIPLVPGCELLSNPFPVDHSDAGSVRLIMECQYRSICRGEHSIFARLRHEGIDPDEYITFFGLRGWGKMISGMLTTEAVYIHAKAMIVDDRIAIIGSANINERSQRGDRDSELACIIRDTDMIDSTMGGKPYKVGRFAHTMRVRLMREHLGVDVDELDAGDEDLLEQTDDETSRQEADEAWDPDNEQKKGDQGGQRVGHTFHWAESVAKTMGENTGSVISGAKETVSLGMQKGAGKVDNHLKGVVDRMDGASDGAVHREEETSAADKIIQGEKGGKGFASTVVPTLEEKVMAEERPTDDQKTKSGLREGKLSANQRERAEGVTVNPPGASGVHEHRNESDDKASKTKQASNDAEKHLGEKMTMSSPEADDVRKFEREPVMEGDDGKSTSTTSSKEEGTELHHKHLDPVVPKTETVDGKSRIQDDAPPPDSKPKDGANGSLSDESSKNRSSSPSTAKASSSTTPSSPSSSASPSAKANEAAANRTTITGTLRRNLRERSNIYSIPVPAPKIDPFGFSDPIVDSFFKNVWLAAAVRNTQAYRKVFRCVPDDLVQTWKQYREFQIWAERHNKAPKDVVSPGDEAPHTDPDHHSGQHGAGGSGSGGGAMGQGQDDPPKGETMHKISTRGDRAASTGNSVTSPTGTSSPADNGGPSVKRDRSGTLAGEGHDHEEGFPGWEREQMEKCLDQLSGCLVVFPTRFLEAESAGGNFLFSKDRLPPLSIYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MI77</accession>
    <name>A0A2X0MI77_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C018g08572 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">BQ5605_C126g13337 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C018g08572</name>
        <name evidence="2" type="synonym">BQ5605_C126g13337</name>
        <name evidence="1" type="ORF">BQ5605_C018G08572</name>
        <name evidence="2" type="ORF">BQ5605_C126G13337</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY25035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000026">
        <property type="protein sequence ID" value="SGY27635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MI77"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY25035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY27635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="115" mass="13305" checksum="81DF92405FF31399" modified="2018-09-12" version="1">MSPQKRIVAFSFKMFLTRLLPSSQLLPKTDISFAPRSSSPLDTSNSCRSLHWTTFRTNRSSSIFYIALSTLLAHGRHLYKTTHRPFLQSVRTRPPEVRTWLSKVRAHPAPLRLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIH9</accession>
    <name>A0A2X0MIH9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">BQ5605_C133g13383 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">BQ5605_C133g13383</name>
        <name evidence="18" type="ORF">BQ5605_C133G13383</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000057">
        <property type="protein sequence ID" value="SGY89105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIH9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="17">
        <location>
            <begin position="300"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="581"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="636"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="673"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="SGY89105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1219" mass="134128" checksum="D70E88F39BB2CE34" modified="2018-09-12" version="1">MSDAGASAPEAKLREPTPDAPPLRPPTHSAAFATTELLRNSSGYRDWSWPASYVPLWDHYACSSICASVDSQTVLPGLSPYLDESLAAPKVWQALRERYGTVSAVDLLPVIQRLFSSDPVPVTPDLFLQFRDSFENDARLLQDSQVTVNALLASHLLARLPSSFDAWRTTFVADQGDSTAMPSATEIFTRLYRDVKARPSILLLPPSPPRRPATAVQGRAQIRLVAKEGLPASRVTLTTILPTCSSPSVSLLTLHRRLAHLPVAQIKNIVQSGLVTGVDWVYKDQELRDFYCNACLASKAHALPFARSKSIASGRLDLLHVDVAQMPRPTFGGHRYMLVIIDDFSRKHWCILLALKSDVFPRLRDWILEVENATGNKVKTIRSDNGGEFTLRNFVDFCASKGIRRELTIPYTPQQNGRVERSNRTIKEGILALLYSSGADSRLWGEAALYYVHCKNLMPHAGIGGEIPDTRWHGFAPDISTLRAFGCRAWHHLPSAKRTDLDPKAVPLLFVGFDQHAKAFRLFEPSTRRIQLSRNVVFRESEFPALRPATDVRAEPIPLPVTVDAYPDQVDPLEPSLVASPRSLAPRAEPPRPVPAAPDQGPHRPAPAREVPDQDSLAPPAPDQGSPARELPDPESPASSASDQGSSDSAISTPCPSPRPVASRALPAPPSPARSDSPDPIDLLPRPRDVASLCQAQEFPDDVDDALHSPSAVAYLASGAAALIETSPADPAELIAPARDPPHWRAAMATPQADEWRLAARDEFDSLLRDFSAFTPIDESLVPADAKVLGSRFVFRTKRDQHGQVKSYKGRLVARGDSQRSGIDFDETFAPVAKFTSIRALLALAAAHGYHVHQADIDKAYLHGKLDAPLYIRVPDGIYMPGKVLQLHRSLYGLRQAGRIWNDEIDSALSALGYVATESDHCVYVRTTGDVHHYIALYVDDLLMISPSLPEIERTLQGLEQRYGVKRLGEAEYVLGIQIRRSPDGSISLSQEQYLKDPDLRLEVELQPTPFPDRTRYLQAIGSLMYASTGTRPDLAYTLSNKPFRYLAGTLSHGLRYARGNPAPLLGYSDCNWGACVLSSKSTMGYTFVYAGAAVSWSSRLQSRVADSTCDAEYLALSHAGKEAIFLRQLFGELGLSSSKPVLIYGDNQGANALTKNPVFHARTRHIRLREHFVRDMVSMGDIVVQYINTGEMTADIFTKALSRDLFARHRGRLGICAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-11-27" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIM6</accession>
    <name>A0A2X0MIM6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C028g10472 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C028g10472</name>
        <name evidence="2" type="ORF">BQ5605_C028G10472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000080">
        <property type="protein sequence ID" value="SGZ12022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIM6"/>
    <dbReference type="STRING" id="796604.A0A2X0MIM6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="1">
        <location>
            <begin position="45"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ12022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="274" mass="30525" checksum="B6643E537C7FABD3" modified="2018-09-12" version="1">MTDKSTPISVTALPRLARTHPAPQLSHLVTSSYAPPKGPKDQLIESNLLILFHGLGDSHTPFFRFGQSLSLPQTAVLSIRAPLRVPLLEEEAWQWWPSFDQLGEVIPSPNPTVTFRVLTQVLDHLLTVCNWHPAQLHFFGNSQGATCAAELILKYFNPTFPSPITFGSLISISGPLISFPTRPARNSTKVLLVSRKTQESILALPNWKKGFEKINSHVLPLHPSPMPTNDKEWFGIIKFWSQVLLRRSPMEFEKDVYAVSSDSVPGDAARPPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIZ8</accession>
    <name>A0A2X0MIZ8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C029g10596 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C029g10596</name>
        <name evidence="2" type="ORF">BQ5605_C029G10596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ14475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIZ8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ14475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="540" mass="57825" checksum="798A677B72D7CB0F" modified="2018-09-12" version="1">MFVALRFGYWDADRESKKHPDIATSKWCNYQLRARVYPRSLTHLPRKVCSSWACPPASQDVRAISLPARYVSGAILSQALLDLIFHTRGIAYWPRRPCLTPRMNNRNNNDTSNATPGAIAPNCPPDPTGVTATAQTRSYSAAVSARSHAKTNATPATATTVASHPMIHNIANCVIIKTPPATTSEKVLSALDHHYPSLAGAMPCVIKGQHGIRFPKDADIVGRVANGLTVGKTLCQVEKLFSATTGVIQCTLSGFFSDVEGLRLFDEQIAEYGKVLLRRTHYIGKTRHISGVYDFVLALEDPNKLPPASISIVHDGVTERIPLRITGGMRHCVFCRSAAHVRKDCPVAPACKSCASTSHASQHCPGRRLASSPQGTPESRPAQASTVTKAPPASKSIPAPPAPDRASKTKKRRVDPDQDLAAQPQDPSNRAQPEPLSETPRPEFSFNFPPNSAPLPASNQGTAPPLVEKSSESPSSETTPPPPSPPPATPTPKMIVTRSQSIAVLSTPATRDDPPTTPAPEASEPTPRPPSLLPSAAPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJS8</accession>
    <name>A0A2X0MJS8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C035g11393 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C035g11393</name>
        <name evidence="2" type="ORF">BQ5605_C035G11393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000064">
        <property type="protein sequence ID" value="SGY97299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJS8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY97299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="165" mass="17282" checksum="B1649E171E7AD8FE" modified="2018-09-12" version="1">MGSPSSSSALDHCAARSPETVPVVSAPVVSAPVVSVPVALPAEEVVVDGSLEPAPGAVSPPSSSPPTHHRVTATGVLATTTTALVHNRLTHAAGGMLSSTLTGLFTREFDLESASRTRPTHRFRRGPDRARAHVKVRQPRSRQSGPWGHDQVTSSSQRAMFAGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJT7</accession>
    <name>A0A2X0MJT7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C020g09169 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C020g09169</name>
        <name evidence="1" type="ORF">BQ5605_C020G09169</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000082">
        <property type="protein sequence ID" value="SGZ18185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJT7"/>
    <dbReference type="STRING" id="796604.A0A2X0MJT7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ18185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="50" mass="5811" checksum="C6FC95251DC7F039" modified="2018-09-12" version="1">MIEDFFKDEKLDGFAYALGQGLEKIRSKAGWLKRDGEDVERWLRGEGFMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKH9</accession>
    <name>A0A2X0MKH9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C002g01375 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C002g01375</name>
        <name evidence="1" type="ORF">BQ5605_C002G01375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY32526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MKH9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY32526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="314" mass="34922" checksum="C8399EA47BE799F6" modified="2018-09-12" version="1">MRSDASSSARAPRSAVDKLSALPSITDLLAALTEQVNSIPTQIREGFDFGLRHLPREPFTPNNHISNDDDASREAAAKELLRLLRDGRIAGRFDYDWLRPQVGSFRFNPLSVTGKRREPGQPPKHRVIENMSYPRAYDAHRDLFWFRLCGCFLPSFSPAVATAAHDDLLGGLNLHSSTDVTQDFLELRFPSITIFKQVDDVVVFCPDAALAPDIGFDWTHCFTCWALHNVRQELSEGKEVLGDANNLVYCFALKPPSTHVDASSDASEIALGIVIDSRTSVFPLPSNWEELRDAHITVAETCAVESAHRTQFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKI9</accession>
    <name>A0A2X0MKI9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C013g07186 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C013g07186</name>
        <name evidence="2" type="ORF">BQ5605_C013G07186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY14967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MKI9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY14967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="53" mass="5725" checksum="E69059C57F810D58" modified="2018-09-12" version="1">MQSWAARAQQHQLQHGSPEGAFSGASRGRILLEEPACERAIPTSAPLVVRSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MM92</accession>
    <name>A0A2X0MM92_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C028g10579 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C028g10579</name>
        <name evidence="2" type="ORF">BQ5605_C028G10579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000080">
        <property type="protein sequence ID" value="SGZ13596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MM92"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ13596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="182" mass="20545" checksum="26ED8F9FA0B45E66" modified="2018-09-12" version="1">MYLLALTLIMRFRHLGFKSFFFTSSAPCWFLMLLISHYGHAWIDGTSLGWGSLAMGGALLFYCRPSDRETYLRRYHSPFNQILLYFIPELALGAPFPHAVAMCILSGKNFTGLKHTLVSEGMIKENLGTEWPRLSAVLNAISPFAMLVTYFNILTFDCVCIALLLKGLLGGISALRQWVRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNI1</accession>
    <name>A0A2X0MNI1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C003g02327 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C003g02327</name>
        <name evidence="9" type="ORF">BQ5605_C003G02327</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY40115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MNI1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000393">
        <property type="term" value="P:spliceosomal conformational changes to generate catalytic conformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08056">
        <property type="entry name" value="MPN_PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13838">
        <property type="entry name" value="RNase_H_like_Prp8_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.230:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000002">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1570.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.40">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012591">
        <property type="entry name" value="PRO8NT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012592">
        <property type="entry name" value="PROCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012984">
        <property type="entry name" value="PROCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027652">
        <property type="entry name" value="PRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021983">
        <property type="entry name" value="PRP8_domainIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043173">
        <property type="entry name" value="Prp8_domainIV_fingers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043172">
        <property type="entry name" value="Prp8_domainIV_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019581">
        <property type="entry name" value="Prp8_U5-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042516">
        <property type="entry name" value="Prp8_U5-snRNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019580">
        <property type="entry name" value="Prp8_U6-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019582">
        <property type="entry name" value="RRM_spliceosomal_PrP8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140:SF0">
        <property type="entry name" value="PRE-MRNA-PROCESSING-SPLICING FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08082">
        <property type="entry name" value="PRO8NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08083">
        <property type="entry name" value="PROCN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08084">
        <property type="entry name" value="PROCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12134">
        <property type="entry name" value="PRP8_domainIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10598">
        <property type="entry name" value="RRM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10597">
        <property type="entry name" value="U5_2-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10596">
        <property type="entry name" value="U6-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="MPN" evidence="8">
        <location>
            <begin position="2192"/>
            <end position="2322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY40115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2424" mass="278170" checksum="96B4AC5513E9A595" modified="2018-09-12" version="1">MTSVAPPGFVFPPGMAPLEVPNYVEPEAMAQETLDAKARKWNALQSRRYGSSRKTQVDPGKQELPPEALRRIIKDHGDMRSVWHPDGRSHNRKFRSDKRVHLGALKYVPHAVLKLLENDGPFIANSMPMPWEQVREVKVLYHVTGAITFVNEIPTVIPPVYHAQWASMWLAMRREKRDRRHFKRMRFPPFDDEEPPLDYGDNVLDTEPLEAIQLDLNDDEDGPVIDWFYDSKPLLDSPHINGSSYKVWNLDLPQMAVLYRLGRNLLSDFNDRNYFYLFEPKSFFTAKALNVAIPGGPRFEPLYRDTDNFDDDWNEFNDINKVVIRQQIRTEYKVAFPHLYNSLPRAVHIPVYHETHNLYIRTEDPDLPAFFYDPMIHPMSTRGLAPRNENITPEQAVFGDSDGESDGRGDAELELPHFIEPFLGECEIETERTADAIGLWWAPHPYNQRSGRTVRAQDVPLVKNWYLEHCPPGQPVKVRVSYQKLLKCYVLNALHRRNSKPATKKYLFRQLKATKFFQTTTIDWVEAGLQVCRQGYNMLNLLIHRKNLNYLHLDYNMNLKPVKTLTTKERKKSRFGNAFHLCREILRLTKLIVDSHVQYRLGNVDAFQLADGLQFTFAHVGQLTGMYRYKYKLMRQVRMCKDLKHVIYTRFNTGPVGKGPGVGFWAPGWRVWLFFLRGIVPLLERWLGNLLARQFEGRNSKGIAKTVTKQRVESHFDLELRAAVMHDILDMMPEGIKQNKSKTILQHLSEAWRCVSSESTGPTPRVYGSRFGSVLAHRNRKTIADPNLSESFSEANIPWKVPGMPTAIENIILRFVKAKSDWWTSVAHYNRERIRRGATVDKTVAKKNLGRLTRLYLKAEQERQNSYLKDGPYVSSEEAVAIYSATVHWLESRKFAPMPFPPLSYKHDTKLLVLALERLKEAYSVKGRLNQSQREELALVEQAYDNPHETLSRIKRLLLTQRAFKEAGIEFFDTYEKLIPCYDIEPMEKITDAYLDQFLYFEADKRGLFPSWIKPADTEPPPLLVYKWAQGINNLHDVWETSEGECNVLMETQLSKVYEKIDLTLLNRLLRLIMDHNLCLDNACFPFLHFAHSQADYCTSKNNIVLTYKDMSHVNAYGMIRGLQFSSFIFQYYGLVLDILILGLQRASEMAGPPQTPNNFLQFRDTATETHHPIRLYSRYVDKIHIMFRFTADESRDLIQRYLSANPDPNNENLIGYNNKKCWPRDCRMRLIKHDVNLGRAVFDLVKNSLPRSLTTIEWDDTYVSVYSKDNPQLLFAMQGFEVRVLPTCRVSNEAFTLKDGTWALQNDATKERTAHAFLRVSDQGIKQFSDRIRQILMSSGATTFSKIINKWNTAIIGLMTYYREAVIHTNEMLDLLVKAENKVQTRVKIGLNSKMPSRFPPVVFYSPKELGGLGMLSMGHILIPASDLRWSKQTDTGITHFRSGMSHAEDTLIPNLYRYIQPWESEFLDSARVWSEYALKRKEASAQNRRLTLEDLEDSWDRGIPRINTLFQKDRHTLAYDKGWRVRSHWKQYQLLKFDPFAWTSQRHDGRLHHLGAYRVDVIAALGGVEGILEHCLFKATAFPTWEGLFWEKASGFEESMKNKKLTNAQRSGLNQIPNRRFTLWWSPTINRANVYVGFQVQLDLTGIFMHGKIPTLKISLIQIFRAHLWQKIHESVVMDLCQVLDQELEALQIETVQKETIHPRKSYKMNSSCADILLFSSYKWNVTSPSLLTDSKDQLDGTTSSKYWLDIQLRWGDFDSHDIERYSRAKFLDYSSDNMSIYPSPTGTLIALDLAYNLHSAYGNWIPGMKPLVQQAMAKIMKANPALYVLRERIRKGLQLYSSEPTEPYLNSQNYSELFSNQIIWFVDDTQVYRVTIHKTFEGNLTTKPINGAIFIFNPRTGQAFIKIIHTSVWAGQKRLGQLAKWKTAEEVAALIRSLPVEEQPKQVIVTRKGMLDPLEVHLLDFPNIVIKGSELQLPFQACMKLEKFGDLILRATQPQMVLANLYDDWLKSISSYTAFSRLILLLRSVHVNNEKAKIILRPNKNTVTAPHHVWPTLEDDEWMRVEVALRDLILSDYAKRNSVNTASLTSSEIRDIILGMEISAPSIQRQQMAEIEKSAEAAAQVTAIQTRTTNIQGDEIQTVTTTAYEQQVFSSKTDWRVRAISSTNIPLRLQHVYVTNDDVKDDLPTFVLAKNIMKSFVCAADLRTPVAAYLYGIVAPDNTRVVEVKAVVIVPQRASQRSVELAADLPSHPLLADMKIVGIISTQAQETQSLTPSDACLYAKLMAQHAEIDGSSMMLTVAFTPGSLSMSAYALTPKGFEWGRTADPNAPAGYNPASMCDRAQLLLSDRILGSVFAPVGDVWNYSVGLGASFTPTMPYSISLVGRPSAYWDPIHRPTHFASFGNIGEEDENVADLDDNYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MP38</accession>
    <name>A0A2X0MP38_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Acyl-CoA desaturase</fullName>
            <ecNumber evidence="13">1.14.19.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">BQ5605_C050g12492</name>
        <name evidence="17" type="ORF">BQ5605_C050G12492</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:19721"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="EC" id="1.14.19.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="13">Expected to bind 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.1" evidence="13"/>
    <dbReference type="EMBL" id="FQNC01000097">
        <property type="protein sequence ID" value="SGZ29736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MP38"/>
    <dbReference type="STRING" id="796604.A0A2X0MP38"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009160">
        <property type="entry name" value="Acyl-CoA_deSatase_haem/ster-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001522">
        <property type="entry name" value="FADS-1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000345">
        <property type="entry name" value="OLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00476">
        <property type="entry name" value="FATTY_ACID_DESATUR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12 13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 13" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="3 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="16">
        <location>
            <begin position="402"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="336"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="354"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR000345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="SGZ29736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="495" mass="55642" checksum="7A46F4D1EFAD6EB5" modified="2018-09-12" version="1">MSSKTMAPTAQPKSATVVERGPIWWSNAIFFVSMHVLALVGATYLSPWHQLRTATMWLCFLSWQLATFGITIGYHRLWSHRSFTAAFPLRVVLAGMGCLGFQGSIKWWVLRHRLHHRFTDTESDPYNAKQGLYHSHMGWIFRKPTYPRMSLIDKKDLDADPVVCFQHKYYIPLTLFLSLVMPSLIGWTWGDPMGGYIWGGVIARIMIQHATFCINSLAHYLGDQAYSEDVTARGNFFLALFTGGEANHNYHHAFPRDYRNGPRAFDWDPSKWIICALHFFTPWVPKMHQTPEAEIIRAKAHVLAVRAEKAAQGLGEDEEGEEESSSSFKVWGTFAEGDSDEDRGSSTSLEGINTSASASASGSGTSTDEGEDDALFDRRSLGRFDSQSLTNRRRHLARQSSLPTWTRAQLVEKLADPKTFLLSSRSPIVIIVNGFAVDVTKYAQEHPGGYAVLREFALGEGKEQRDATEAFEGGLNDHGWSAREKMKDLTIARIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPS8</accession>
    <name>A0A2X0MPS8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="30">Cystathionine beta-lyase</fullName>
            <ecNumber evidence="5">2.7.1.36</ecNumber>
            <ecNumber evidence="6">4.4.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="27">Cysteine-S-conjugate beta-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="33" type="primary">BQ5605_C024g09924</name>
        <name evidence="33" type="ORF">BQ5605_C024G09924</name>
    </gene>
    <organism evidence="33 34">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="33 34" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>(R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17065"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.36"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:17066"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>L,L-cystathionine + H2O = L-homocysteine + pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13965"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:18121"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29256"/>
            <dbReference type="ChEBI" id="CHEBI:58717"/>
            <dbReference type="EC" id="4.4.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="26">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homocysteine from L-cystathionine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="25">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.36" evidence="5"/>
    <dbReference type="EC" id="4.4.1.13" evidence="6"/>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ26483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MPS8"/>
    <dbReference type="STRING" id="796604.A0A2X0MPS8"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047804">
        <property type="term" value="F:cysteine-S-conjugate beta-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004496">
        <property type="term" value="F:mevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000013">
        <property type="entry name" value="Cystathionine beta-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000009">
        <property type="entry name" value="Cystathionine gamma-synthase homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000003">
        <property type="entry name" value="Mevalonate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006238">
        <property type="entry name" value="Cys_b_lyase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006205">
        <property type="entry name" value="Mev_gal_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01329">
        <property type="entry name" value="cysta_beta_ly_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00549">
        <property type="entry name" value="mevalon_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF50">
        <property type="entry name" value="CYSTATHIONINE BETA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="19" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="23" id="KW-0456">Lyase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="34" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="22" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="18" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="20" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="32">
        <location>
            <begin position="583"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="31">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00029310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00029438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00046315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00047213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00047517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00047625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00072331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="EMBL" id="SGZ26483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="901" mass="97010" checksum="53CFFC32EEAFA5B9" modified="2018-09-12" version="1">MSNSPPSTTESGSSTPVSSVSHSNQSLTSSLLRAKPYRFATQCATVDNPDPSHRDQYGSSSVPIYQTATFKGMGGQYDYTRSGNPTRSHLEHHIAKISSARYAFAVTSGMGALDVIFRLLKPGDSIIAGNDLYGGSNRLLTYLKAHNGIHTHHLDTTRPDTLLPVLQNPDEKVAMVLLETPTNPLLQIVDIAAIAQLVRRYKPDAVIVVDNTMMSPYLQRPLEHGADVVYDSGTKYLSGHHDLMAGVICCNRDDVAKGIAFTINSIGNGLPPFDAFLLLRGVKTLALRLDKQQATSQLVAEYLDDLGFKVNYPGLKNHPGKAIHDRLASGAGAVLSFETKDKALSERIVGAARLWGISVSFGCVNSLISMPCLMSHASIDPKVRKERNLPEDLIRLCVGIEDPEDLIDDLEAALLEAGAVRVVDEAGERHKLERVVGPDEAPLASLSLSEGAQVEEELESLIVSAPGKVILFGEHAVVHGIMAIVGSVDLRCYAHVESRHDGKVALNLPDFDFTAIWDIATLPWDQVEASAKAPRPESTPDAALLSLLADKIVQSREPKVVQSEQAFLYLYMHLSEQKRLSQTFTVRSALPIGAGLGSSAAFSVCVASALLYTHSQLPLPRLSPEGHHDGRRSIAHNAAEVVNAWAFTAEKIIHGTPSGVDNTVASWGGAIAFTKAVKGRAGSLEGLHGFKSIRFLLTDTKVSRNTKALVEGVAKRKLNEPDLVNPILSSIQAIADEARRCLLDTEMERKEQLRTLEGLIDQNHAHLVSLGVGHAALEAIKAKTGEEPWKLHTKLTGAGGGGCAVTIIPDAYLCKFERTDFSEAALDDVKASLHDAGFETYETKVGGSGFGILSHNNLNRSVVEAEGGAEMAVLPDVVRFKQAPASELAAWAQAESGWAYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQK2</accession>
    <name>A0A2X0MQK2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C025g10053 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C025g10053</name>
        <name evidence="3" type="ORF">BQ5605_C025G10053</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000087">
        <property type="protein sequence ID" value="SGZ27097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQK2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097196">
        <property type="term" value="C:Shu complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28498">
        <property type="entry name" value="ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28498:SF1">
        <property type="entry name" value="ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="75"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ27097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="161" mass="17283" checksum="9FFDE595CFCE1DF2" modified="2018-09-12" version="1">MTTPTNVALSTLIASHLASIDSTLTDDHLIVLAHLVGSTNLIVDALHLIDTQGVARLNLPNRQSLYQVSGSTKAYTVHTTPSAASIGRLGFCPCPAFAYSVLKTQQNVLASQAPHILLGCKHLLAVLICERLDTFVDKQVGLKWLAAWSSGFRTLQQVPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MRG2</accession>
    <name>A0A2X0MRG2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C069g12863 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C069g12863</name>
        <name evidence="3" type="ORF">BQ5605_C069G12863</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000131">
        <property type="protein sequence ID" value="SGZ35094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MRG2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="713"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1316"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ35094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1560" mass="175674" checksum="04DE1E2B6E69E218" modified="2018-09-12" version="1">MIIDDGQTTITTVSRESTPRSPSWPPLSPETLAKSLREGAEWDRANAEAAARVQAENEAIINAQLDAQEPLVRHQFAEWGQEDGQLRFINIRGTGSRSNKKMKRSQTVADLSDPSDDPVDVKRVLNRVKGRAGKEVAGQGKRVTRSMSAAAAMQVEGAKAKAEKGKGVEEEKRWSDHEPEDDILPEFPLFEDNITAKSTWNVRRCMGIPEKRRDIYTYLSTFKASAILLQEHFIKPELWQCIKDEYEGKAFISKHCLTLIPADSPLIDAEILRTHSALDGRILVTSFRLRGDIRILEINNLYAPVDTKQRLTFFDKLHFHRTQSTHLRLLGGDLNDCPLPAIDRRNQGRHGHHWPILIGKLDSPYTDCIRFKHPLTPSFTRPNIVRKRPKSFSRLDYFLLQRTHQKRLVQASTIYDHPKDLSDHRPVSIVLVLSDERGDAAQPNNSLPTTSNQLHRINAATFKTAAFQGMLEGWLEGASGEEPVGELEVVLGNCEKEGRELARREHRERVERMAVLVGRVQDLEALPVMGDEETAEWTRTTEELRRAVNERARQLRIRAHVPEIATEERLSRPVHAKLAARSSDSKITALRLPNGELTHDIDVALDHTQAHFQRLYNLEPRDRDHVERLRDDFLAPIRSARTCDDPSSDPLFLRRLSEAHIELLQQPITEDEVVAAIATTHPGRSPGPSGVPYELYHTAPRAWAKALSRAFNAMTERGSLSPRQGQGLVRLLFKHHKIGADRAELSSYRPITLRECDYKLFTKVYVARLNHVLPDLLPPQQHGFVKGRRSADASFHLRLLIEELGARGTEFPDAALLSLDQSSAYDLVEHEWIFAIFDALGAPATFQRVLRMLYSGDSTTARYIINGFLTPPVRLTCGLGQGDPASSSVWDVVFQPFLDALHRRGIALNLSLPTIHPYPQSRAITSLAFADDVVVAVAGSESLTLLDDLALDWRLATNGRLNTDKTVVLPIGCRWEAGDRPLVVKAEGESLEWIGLSFDPTGNTELANMNLVARLEAVLDSARDRGLTHHTRAFYVNRYAIPKILHILSASRPTPVPCRIEHRFEPCDEIHVGEFDVAGGVVKELDRILVDFVRGGKRRSCYGKDVVFTPRFKGGLGVMRMQDVVDSVAARVWDVLLGGSDAIWQGLARAAIVRAHPAPDFDLATDAWPCDYTPIRTDLHPRWQAVLKVPSTHNAQVKPRTLTLANLLALPIKLHTLHYLPGAPAVSRSPYDADYAAFANYAKVADLFRRELYPGGGFHLWTPPTDVVVSNSEYDQRGRPQREHIVAWYRHAINRLRFTPIAQPVAAVRINGPPRVRPRSEVRPTTPLESILPHPIDPPQRLPRPALPDQSTQYNLLSMDRPYTIRRVRRVLNAKAFTDTIGFRDSLQPDDLKGFWKGVNSKALTAREREVWFKLVRNFTPTRSLQFHQKHDDSPACLVCGAPKDDREHYFFDCVDSGNVWIAARSVLCDALGLDTIDNTHYTAVQRMFGLPKLKASLRDQEGAGRTIEIFTGLILEMISSGRWGMQKWGTRMEGVGRRRIILEERLKLRAGGAWGRRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MS86</accession>
    <name>A0A2X0MS86_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C112g13226 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C112g13226</name>
        <name evidence="2" type="ORF">BQ5605_C112G13226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000106">
        <property type="protein sequence ID" value="SGZ30268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MS86"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ30268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="490" mass="55985" checksum="C374DB9658771DCD" modified="2018-09-12" version="1">MVVTAWIGKKARSFYWIVFCRLPTAQQPALETQPRRDIRRCRVKKKKIKKKKKKKKQVAARVWDVLLGGSDAIWQGLARAAIVRTHPAPDFDLATDAWPCDYTPIRTDLHPRWQAVLKVPSTHNAQVKPRTLTLANLLALPIKLHTLHYLPGAPAVSRSPYDADYAAFSNYAKVADLFRRELYPGGGFHLWTPPTDVVVSNSEYDQRGRPQREHIVAWYRHAINRLRFTPIAQPVAAVRINGPPRVRPRSEVRPTTPLESILPHPIDPPQRLPRPALPDQSTQYNLLSMDRPYTIRRVRRVLNAKAFTDTIGFRDSLQPDDLKGFWKGVNSKALTAREREVWFKLVRNFTPTRSLQFHQKHDDSPACLVCGAPKDDREHYFFDCVDSGNVWIAARSVLCDALGLDTIDNTHYTAVQRMFGLPKLKASLRDQEGAGRTIEIFTGLVLEMISSGRWGMQKWGTRMEGVVRRRIILEERLKLRAGGAWGRRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MTU4</accession>
    <name>A0A2X0MTU4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C041g11978 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C041g11978</name>
        <name evidence="7" type="ORF">BQ5605_C041G11978</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000119">
        <property type="protein sequence ID" value="SGZ33596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MTU4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF52">
        <property type="entry name" value="SINGLE-STRANDED DNA-DEPENDENT ATPASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="783"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="1505"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="106"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="198"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="303"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="367"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="866"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="941"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1024"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1068"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1318"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="231"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="320"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="372"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="422"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="961"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1027"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1074"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1353"/>
            <end position="1362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGZ33596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1667" mass="179929" checksum="FC8FA79100E81BA1" modified="2018-09-12" version="1">MEFANGFEEIEVRTRPTPQSPSKVHHNEEVGTPSDLGGATAGASMIYQSSATQPTALTTGVVDLTESPPSTTLLDDSWAWSDMAVSAPAAAPSSAAPFRARDAMTTATSTLVSGVSSRSSGPLAGGRFGGDTRYNKPTPLPLNVASKPLQQPGSSSNSNPNPGAIPNPSASHSAMDSESDSARTAAVTFGASSTAFATAPTSPFVSTPSTSSAANPALGFGSFANPHPTRSLTLPSSFSPTVSSASQASPMLASFAQVRSQSPAADNSGAFNSAALASTSTKPIVFASQLLPGHATSAFRSPALAKAASTHPTPVAGPSASRSLPGSTPKRQGSTEKNGLSSNSIQSSPDPLQAYYRMQAASVAAARKSASDNMPTPTGRSGTFPGSSRPFVPLTAPHPSSSLNPNAGAGIDHPQQSRNGRAVANSAVASTSSSGSNTMIDLTEDDIPSDPDEMIIDDHPICIGQITSLALILYPIPELQPPAAAVDDKGRPVPAAQQLPFAQQPPPPLAVYIYRGDAQQGHETLRLVSSRRKETFGVVEHRVADVIGPLLGNGWSGAGITPELGGKIWCEAHVMRKVERSPTLLPLVLLLFARPLDVPAISSTLERNTIYLEHPSAYNPALHSGARYSNPHNPAAGRASERRRHDFQAGIYGLSGLGATRVVSQKDEARSQVDEVFKSLKSVMELDEVEPRKFGCTGDPSLPTVADMCDPDLRTAPMVTTKLYPHQKQALSFLLDRERIHEVPEKDERGNPTILSLWSRESNPYGQPIGWKSVVADLRISGPEPPPQTRGAILADDMGLGKTIAIIALVATTLDDARKWYTAPIDRENRDDRVDSLVTKAAAPPKLGIGDFSGRAYGFVEYGNPTASASTGRPLSKKKQAAAKREQKREDAIAARHNRLVTRSRATLIVCPLSTVQNWESQFEEHTGYADGRVYTVTSGLPKLESDEEDEDSGGATDGSEEYKPRPKSERNGKKAATAQAAAAAAEERAIKVYVYHGNHRIQDPIRLADYDVVVTTFSTLGTEYSRQSRAEDEREAEASREGSSDDMLEVFVLGPNGEHVETRAGDPIVKAGKPTKPKRKRRKLEGDGASPLQQIEWYRVVLDEAHIIKEHTTIQARAACELATPRRIALSGTPLQNSLNDLFSLVRFLRLEPFTDRSVWNQHIGSLAKIGDPLGVDRLQLIMRHLALRRTKESTDKDGKPILSLPPNKSDLVELQFSPEEHAFYQVHHQRYKHDFAKLEETDSVMKNYCSILQELLRLRQICVHPALVRDSEDAKIGGTGVVESIKQYGISRQRAIPLLLLMRDAGGGQCSECGTEMLPVAGSNDERADEVEDESRMEKKTPAKKSRKTAKASTASAAASDAEDNGGGPASPNELRSVVTRCQHLFCRLCFIHHIYNDWASPKAGDTAPCSVCKEMLKPVLDAVEIGATEFLRATEKADKGDVKPTKGGKKSAADRVFEHSTKTFALVNDLRPFSQANPASVNFRGDLYTSDEPREGETRTIGFQPHKGEVVKSVVFSQWTSYLDRLGDALSSERIKYGRLDGSMDRDARSRAMMAFKTDPACEVLLVSLRAGGVGLNLTAGRRVYLMEPFWNPAVENQAVDRIHRLGQTMPVQTVRFVIKTTIEENMRKIQKRKLDLANMSVKKTLSKAELLQQRKEELAILMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MU78</accession>
    <name>A0A2X0MU78_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial distribution and morphology protein 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mitochondrial inheritance component MDM10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C002g01677</name>
        <name evidence="6" type="synonym">MDM10</name>
        <name evidence="8" type="ORF">BQ5605_C002G01677</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the receptor TOM22 and small TOM proteins. Can associate with the SAM(core) complex as well as the MDM12-MMM1 complex, both involved in late steps of the major beta-barrel assembly pathway, that is responsible for biogenesis of all outer membrane beta-barrel proteins. May act as a switch that shuttles between both complexes and channels precursor proteins into the TOM40-specific pathway. Plays a role in mitochondrial morphology and in the inheritance of mitochondria.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. Associates with the mitochondrial outer membrane sorting assembly machinery SAM(core) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion outer membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="6">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MDM10 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY34754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MU78"/>
    <dbReference type="STRING" id="796604.A0A2X0MU78"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051654">
        <property type="term" value="P:establishment of mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03102">
        <property type="entry name" value="Mdm10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027539">
        <property type="entry name" value="Mdm10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28035">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28035:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12519">
        <property type="entry name" value="MDM10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1 6" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="300"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY34754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="552" mass="59551" checksum="5A2609AC017447A8" modified="2018-09-12" version="1">MVYPQAAYLLREHLGATNWSLDNHYHALTLSSRNLLDFPIPPGLHLSLSHRPTSLLASSLQLSTLAPSGSTTYNTYAQANAPVLGPPVNPLLSGQLGYFFSSAPLGHQSTKREQQHHKAASPVAASAGLGNLQLVIDEQPVDLLQQHTECNSEGGFRFRDAVQSFHACDPPIKPRTRVADPNTPTTADFLMYGRLYAPSPRLDALYAHRLAPTVLGLVSLISVPAPIAPPKLSWQPNDEASSMTINAPPTSTTSARLSELEFKLQHDTGKWSTEYSYAVGDGMWGARGLYNFGYSGASSAGGPSSSGASGSDGVTTSDDSPSSHVRERVVDEEEATSTGLKGRWSAGGELYFSAQERSAGMSTGLRFATIPYPELHGDHASSHPQPPTVMTATLNPFMGQLSLAYAVQTSQVAALASRFDFNTYSYEAELTVGGEWFQTRRHRAKMREEGSLGDVEETRIKEKMKSWDAFGRGTQGVLGREERKEGTRDDDEVVGVVKARASTNSDVSLLWEGRLGDFLVSLGVVADLRLATKSAGRVSPIRSIGVGLQYWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MU94</accession>
    <name>A0A2X0MU94_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C007g04479 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C007g04479</name>
        <name evidence="2" type="ORF">BQ5605_C007G04479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY60744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MU94"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY60744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="261" mass="29065" checksum="80543688BC2C6EBF" modified="2018-09-12" version="1">MTMLICDSDTNTGDRGPQELIVQVRSHRCPDGRPKYQVVSSLHPSAMPLRYPTFFAAEENSSHLNTPLCGFHQAGPPIARNREQIDNGVQLREVLPVSVWMTNEEDKDRDDEDEDREEGDEEDGDGERQRSSKGVEVASLAFTILCALLAKGDEYFSIPHCTHGPFLESVIYGYTPSRDRSTLHIRLHQENLHLTTTQGINGLAPNPIGRCTGADKACNRPDLIARVFEAKSGNKRHAGCFGDECKMNGFCFFAVLRVVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N0L0</accession>
    <name>A0A2X0N0L0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g04230 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g04230</name>
        <name evidence="2" type="ORF">BQ5605_C006G04230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY57160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N0L0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF463">
        <property type="entry name" value="REVERSE TRANSCRIPTASE TY1_COPIA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="64"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY57160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="505" mass="56574" checksum="5B0F14FDC5EDAE02" modified="2018-09-12" version="1">MVDVLDTPPMFHDKLSYDAYCAAVFAEEDIEIPKTFEEAMKSPYRNHWSAAMVSELLQFNHHGVFQEVKWHKGIRVLGTIWVYSIKRDANGKIIRFKACLVAQGFAQRPGINYHDTYAPVARSSTILFLIALAAAQGLYLEQFDFDCAFLNGKMTEDVYVRYPKGWNRPQSPGKCLKLVGSMYGTKQAPREWATADACLYIKHSGTSFAIIAIYVDDGLITSNNQSFLDSELGSLHKAFQLKRLGPVSYFLGFEIHRTKDYILVHQSKYVRTMLEKFDFASPSKRRAVTPMDNRPSLRIDATPFADVSLYQSANSCPTVDDWAAVKRIFRYLNSTIDLGILYRNSSTTQLMVYSDASFADDPESRRSVGACASMLAGGVISWQSKQQSMIATSTTEAKILSASSATREAIWLRRLAGDVGIPQAQPTIIQEDNAACIQIAKDPVDHMRTKHFDIAHLFVRERVASGEVELEYCPTHVNAADIMTKPLGFQRFDQLCALLGMVSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N2H4</accession>
    <name>A0A2X0N2H4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C004g02644 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C004g02644</name>
        <name evidence="2" type="ORF">BQ5605_C004G02644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY66223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N2H4"/>
    <dbReference type="STRING" id="796604.A0A2X0N2H4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY66223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="311" mass="34074" checksum="250679BFFD00C36E" modified="2018-09-12" version="1">MTTKRPVLALQTLLHDQQQQEQQTPQRLRSTSASNDARPTTFRPQAHSLDQSILKSPIQFVASPGALSPVQADFQFPFHPSSTSLSRPASRHGSPRSKSTSARREGNDTSTFNQIFGQLDRIDQLQKQLAIRHAELEKVGSGSASLSSPQPPPPQPASVEASLKSSSATAATEEGSVHTEKPDDESSKCRADYDKLKKSLDDRRPRTDQLMAMVSSLTRSPTSLAHHSFPGLTSHLELLQLEELSTTLKTFHALPTPMTCPQTSSAPMSPVYPPFAPSKDRNEAARSRTIIEPSAGLPDRRRGVQRHLSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N3A2</accession>
    <name>A0A2X0N3A2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C004g02934 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C004g02934</name>
        <name evidence="8" type="ORF">BQ5605_C004G02934</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY68963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N3A2"/>
    <dbReference type="STRING" id="796604.A0A2X0N3A2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018983">
        <property type="entry name" value="U3_snoRNA-assocProt_15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924:SF26">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924">
        <property type="entry name" value="UTP15 U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09384">
        <property type="entry name" value="UTP15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="120"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="163"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="278"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 15 C-terminal" evidence="7">
        <location>
            <begin position="406"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY68963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="558" mass="61328" checksum="9FC1048088914D1C" modified="2018-09-12" version="1">MAEFSRLVVPKPPRTSIESEQKSESVYWKSYKSPIFIKSYAPVTHVQFSPSSPHRYIVTSGSRLQIYSPKTNRVVKTIARFKETATSGEIRHDGKLCVAGDHSGAVQVFDINSRAILRTIKAHKQTVHTTKFSPGSGTQILTTSSDTTVRLFDLSTSANVRIYPRHTDYVRCASFVPSSPSLVFSGAYDGTVRLWDSRQAERDGQVWLGKHGKPVDEVLVGDNGTLACSAGGPILRIWDLLGATTSSITTVDHTGDEAPEYEDDERLDTGTSYCVRALSNHQKSITSLCWAEAENGEKRVLSGALDGLVKVYDPQNNWKVRHTMRYGGQVMSLAVSPNSSHLVAGLSDGSLSIRTRVASKKAGLPTEFKPPSYDALLAGAAAGGVVYEGKEAMEGMGAFEGEQKMGKDRKKKLMEWDRMLKNFRYGDALDSVLRKGITTPTTFALLEELIHRDGLTIALANRNDLSLEPILKFLVQHITNPRHCILASDVANALIEIYTPTLGLSPLVDGLFNRLRRKVDEELKFQRELIAVRGALDMVFASSQQGNKRAVAINAITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N470</accession>
    <name>A0A2X0N470_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C030g10841 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C030g10841</name>
        <name evidence="2" type="ORF">BQ5605_C030G10841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000069">
        <property type="protein sequence ID" value="SGZ09101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N470"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ09101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="143" mass="15759" checksum="88146745BDC37496" modified="2018-09-12" version="1">MMTMGSSSNTALYERRRTNFTTGAERNVVQDGSDHHQNLSSTLSSSTDSAWLSDSGTLSGSPPSSSAHRTSHSRPSHFLNPHHHLPESNTDSDRQIFTRNSRQNSFKHDSDSSASDSATEPLFEQHTPSRMGATSPDADWERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N503</accession>
    <name>A0A2X0N503_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C005g03556 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C005g03556</name>
        <name evidence="1" type="ORF">BQ5605_C005G03556</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N503"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY77102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="48" mass="5406" checksum="92CE7C9DB9ED1EBF" modified="2018-09-12" version="1">MRHIATSSPVRMRSLVTTSAATLIANAYVCRKEVLTARVHDQIRCKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N6Q0</accession>
    <name>A0A2X0N6Q0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C008g05327 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C008g05327</name>
        <name evidence="2" type="ORF">BQ5605_C008G05327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY80208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N6Q0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY80208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="259" mass="29393" checksum="A81A8AD6B9076084" modified="2018-09-12" version="1">MLHIKNPKRYKTAIRIHDPDNPRLWRPAVKTTHTDLRYSFSASTTRRLMQQGDQEQAAARRRAAGVGPRETTPDPLAGAASGSEPDNDHDDYNDYNHIDQRDYGDVMGFNIIFPWCRSFSTGHPLPRKRVPPRRAVRSYAMNTWLAITNWRCVVRKLVEDFLTAIEDDREYVPLQSVPLGSNKAMEVILIDFSAHKNVSFVPSNKGAISDLLAAGYMPATPVAPRYAFFIPFIKIHMAYHYVAKATPYDGANLLEANHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N7C4</accession>
    <name>A0A2X0N7C4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable RNA-binding protein 18</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">RNA-binding motif protein 18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C023g09645</name>
        <name evidence="7" type="ORF">BQ5605_C023G09645</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ23845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N7C4"/>
    <dbReference type="STRING" id="796604.A0A2X0N7C4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12355">
        <property type="entry name" value="RRM_RBM18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039157">
        <property type="entry name" value="RBM18_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="43"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="123"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGZ23845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="238" mass="25470" checksum="F1A9DF4C0A8F44F6" modified="2018-09-12" version="1">MGIPRRALVFLPPTSPPRDRAFVRFSIVSSQPMAPHAKGFSATRLYIGNLSPSTDEYTLMQLCSKHGKIQQLDYLFHKSGPLRGKPRGYAFVEFSTRDEALRAMVAMDDQLVRGRKISVTAASAQQTYDDATSSAGKGRGAGRGSDPTRPTAISLLKSQNSGGGSTNKKIAALEAKLAALRKEKPKEGTTAKLTAATSEAKKLESSIAKVVDGDNFLDAIEKEMQVGPSEAPGGKETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NA19</accession>
    <name>A0A2X0NA19_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C033g11221 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C033g11221</name>
        <name evidence="5" type="ORF">BQ5605_C033G11221</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000066">
        <property type="protein sequence ID" value="SGZ02655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NA19"/>
    <dbReference type="STRING" id="796604.A0A2X0NA19"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24094">
        <property type="entry name" value="ASKHA_NBD_HSP70_ScSse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000171">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000004">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF4">
        <property type="entry name" value="HSC70CB, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="512"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="758"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="513"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="530"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="766"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGZ02655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="816" mass="88967" checksum="E97E13344321A653" modified="2018-09-12" version="1">MTSVIGLDIGQAGSKIETDAFKATQIGAARNRGIDILINEVSNRATPSLVAFGPRSRIIGESAKTQETSNFRNTVGSLKRLIGRTIDDPDMEIEKKFLSAELVKAGNTVGVEVNYLGEKTVFSATQLYAMFLGKLRDTAANELKSAVNDVVIAVPVWYTDAQRRAVIDAADIAGLNPLRLINDTTATALGYGITKTDLPLAPEPPKYVAFVDIGHSDYSVSIVAFNKGQLVVKGTAFDRHFGGRDLDYALVEHFAAEFKTKYKIDVKSNPKALFRLAAAVEKLKKILSANPIAPLSVESIMDDVDASSTLKREELEALVAPLLERTIGPLERALADAGITKEQIETVELVGGSTRVPALKSRIQEFFGRPLSFTCNQEEAIARGATLACAMLSPVFKVRDFSTTDTQLYPIKFVWEAAPGDDPSEGTELVAFDKGNVIPSTKVLSFSRNQPFDLEARYAKPEDLPGKSNPWIGKFTVKNLSAPKDGGRALVKIKAKLNLSGILTFDSATLVEEGPEEDVPEPEAMETDTPSAADGEAATPAAPTPVKKARKSIKTTLPAISSANSLDASLVNDFKEKEGQMHSSDKLVLETEDRKNALEEYVYDVRDKLEGAWKKYSSEVEKDGLRKLASEAEDWLYTDEGEDATKSAYVARLEGLKALGEPIALRYREHEERPRAAAALREIITGFLEKAQSGDEKYSHIPEKDLNTVVETCANAEAWLGNKLYSQQEKPLDVKPVITSAEIRKKGEEVQNICLPIMTKPKPRASKTETPKAEEKPTTTEQTPDVNMEAEDTTAPEVPTENKAEGQAGMNVDELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NCA9</accession>
    <name>A0A2X0NCA9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C020g09083 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C020g09083</name>
        <name evidence="8" type="ORF">BQ5605_C020G09083</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000082">
        <property type="protein sequence ID" value="SGZ16952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019783">
        <property type="term" value="F:ubiquitin-like protein peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="7">
        <location>
            <begin position="881"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="1226"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="992"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1116"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1502"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="996"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1052"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1517"/>
            <end position="1527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGZ16952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1542" mass="174032" checksum="A055003E4152AC0C" modified="2018-09-12" version="1">MSQLLQNKGGRPPIALQEQSSPEGYASEVDSEVDEDEDSLQVLAALVPVPSKSSISSPSAVSGLLISPKSRSRDSDEDSADEGYYGVDDDNSDEKSIDNIFSALLLARNDKKILDRHTYEPSRQDKELLNTTREAIFSNMILTTAEHNELRLRPLVLNCRKPRSEWEFVRKLPVLELPKFMATEKHDWAPRKYERCLAVVERPYGDAPSSTHHQHPSEVAVGIEWRPEVPITLREAWSQPGEGRPVAEVLRITHRCSGGCKRVRVKDGKLGYKKRDNDKGPGKTCSTQLKILVQADDLSSALVYTLGNHEGRQPPPNVRRPAPFIRALAHQEVFRQANTPTLAFQSEGVLQVCTRSFHFSRLTISSFLDDGLDHFTDMNQRMSVWEKQNEIILPQYRKVGAKQLRNMFRAKGRQNAQHGSALYSLARTAELRPFTLQIATEPKTRGVAYFQPFNEKTKQPLICVLASLHSIDVLISFATVGNDSGDCDWSRFVGLDSSWRYLNENRAPLTALVATGLKDKLALGPMLLSSDVKADTLVIYLDTVKRLVEERAAILVRKARENGPNLPGSSPRFPNLLQNAEFILENQWQPPNFMIDKCRTELNALTLYCSHDFEFLMIVVFCIYVTIGKKKHNLNFHIRLCQFHVVQAIIRWSSDRNDGERGNTVKPSRIARKTLINILYEFRSIIQRFRFIRTEHETDAEATARRSAEFEEKKRAFFEKSDAWIDKEFRSRRKPAANKSDVTKKSELGCNSREEEQLQAKKDNFRAYFNVNWFVQEWIDDGLPLGVSRETINTNNVTERASKTIQQEHLHGRANKRIDNLVVVLPDNALVYDIWKDVSNAKPDHVLRDTLANSMDIWELGQFRPTEKEGQWVLSLRSMDSSITLDTRAPYCPCRAFKQTGNKCAHLWACDLLVHNGDYHTAMSASESFDHTRSGFTSLQSDNWCGISLADRIMAAAAAAKAMSDMRDGTKSSKLHDASVEALVDKVLDSKMPSALEDDNEPDEPLSEDELDERDEVDSDVEDEDERAADIADVAEFQPNCSTVKARDRPLQPHRSKKTAKPKLSKSKSNSGITLEHSGRVDGKATAAIRRLIRDKLNPDQLRPKTSKHTIFENGTTQFGKTRGRPRETKFSNSLSSTKDHAAAKRMAAIPEVIDIEELSDDERSPCQLAPLQEGRLPLDIYDTVQPEERRSNVSAVKDIIKRILNEVQKVDWDVFLDIHAGDHAPGLNLSSLREMANANLWLRASHIDAFSSAINRFQGQLPFNGRSKEVLDLEPTCYAFYLEGGKCAKGIGGTRPTERQQGVSSDGSSRAYLSIIIDRRPASLFALPLYQIILSRTPVLLFPTHVTNHWILVEARLSDCTFRVYDSLFGRENMRKEANESLDSIITFLETRAEGPIERITGGIDRPTVPYRNWKRLIVKAAKAGDQPQPDRYPQQTDGNACGAFVCRAMETLVCAAVAKMEPDWSWGPQVEPGRFYSELRDYMLDVTLHSRLRCDMSSSWFSGSPESPTVSCATRDPDNTMDSRKPHGNTQPGDHVGEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NCV2</accession>
    <name>A0A2X0NCV2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C074g12904 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C074g12904</name>
        <name evidence="3" type="ORF">BQ5605_C074G12904</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000129">
        <property type="protein sequence ID" value="SGZ34917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NCV2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010286">
        <property type="entry name" value="METTL16/RlmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393:SF0">
        <property type="entry name" value="RNA N6-ADENOSINE-METHYLTRANSFERASE METTL16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05971">
        <property type="entry name" value="Methyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ34917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="444" mass="49565" checksum="ECA47C2358A3D592" modified="2018-09-12" version="1">MPHVHNPYADGPPDYSQLAQDVPYFAPFLRTNPYGGSTIDYKDENALRALSSALLERDFGLRIELPRDRLCPIVPGRVEYVTFILRLVHLNPQRSSHVRGLDVFLPVLQWHRCFRIYALLVAKMQADAFVYGSEVDEHSQSCAIRNVNANNLTARVQVVCSTREEDPLFPKETWADNELDFTMCNPPFYESEVEIRALATEKDGQPSAVCTGASNEMVTKGGEIEFVGRMIEESVRLGSHIRLSQLIAKLKTHKISNYIVHALSSGRTTRHILVWSLGAWRIPQVCYRPLPGEYSWAAGMQSLAQITPFTTKFSPPVNSVTFRAPSEMDAPTLYNLVCTILYSLDGVKTSHSAPGVIQMRAACNSWSRSARRMARNPTQTGIAGQNTAGTGGNQIEATFTALQDDGEDAGCSLRGEWTQGSEQVRADWLKLWAHVTRKISDHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NF57</accession>
    <name>A0A2X0NF57_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C025g10020 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C025g10020</name>
        <name evidence="5" type="ORF">BQ5605_C025G10020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAP domain-containing ribonucleoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000087">
        <property type="protein sequence ID" value="SGZ26995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NF57"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052240">
        <property type="entry name" value="SAP_domain_ribonucleoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551:SF1">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="4">
        <location>
            <begin position="9"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="44"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="142"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00046328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGZ26995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="255" mass="26564" checksum="F99B9751797E6B16" modified="2018-09-12" version="1">MTPHTETSLKALTVPKLKDLLTAASLSTVGKKDELIARLLEAKVENGSSASAEPEAAATSTTTTKVEPIALTENAVASSTEAPSTDAASVTPAAPAPAATPAVPEPTAEEKAERLRLEQEKRAARAARFGVVGNGATAAAAVDEMAKAKEERAKRFGLPQEGEKEKQDQLDKSLSALDRPLGEKRAREPKAPKPATGAPNSAAATPAKAAAPAEKEKEIDPELAAKIAQEEERKRKRAERFGAPAPVEKKAKTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NF90</accession>
    <name>A0A2X0NF90_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C025g10060 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C025g10060</name>
        <name evidence="1" type="ORF">BQ5605_C025G10060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000087">
        <property type="protein sequence ID" value="SGZ27120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NF90"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ27120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="82" mass="8779" checksum="40CFA0D9BB360A88" modified="2018-09-12" version="1">MPHYPVAAVARSTNQQLTGAAAIQAGLSEVCSNRLIVSGLSATSATSAKGTLDKYLLHNFWRTPFEATQVQDLVGPCKPRQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NGJ0</accession>
    <name>A0A2X0NGJ0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BQ5605_C051g12551 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C051g12551</name>
        <name evidence="12" type="ORF">BQ5605_C051G12551</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000096">
        <property type="protein sequence ID" value="SGZ29599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NGJ0"/>
    <dbReference type="STRING" id="796604.A0A2X0NGJ0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0229">DNA integration</keyword>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Retroviral polymerase SH3-like" evidence="11">
        <location>
            <begin position="171"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGZ29599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="325" mass="35672" checksum="21D5819937516C35" modified="2018-09-12" version="1">MEAHRKLGHQSPAAIVLAVKSGAITGITLKDEKVTPCFFTKVPHALYRVFINLGFVKHPNHHGDTIYLAIVEQYSTAKWMIVLKDKRAEMIIKAWSKFQPESEQFTAPYTPEQNGQVEQLNGSLMGLVRSMLLDSGLPMQFWSDALAVATFVLNLLLGKKPSLAHLQPFGSTVFVHVPKERRSKLAFRSIQGVFIRYSGEYNYRVWVQLSQQVYVLHHVTFLETPSVFTLSQDRADASDPFAGSTASSGGSNWSWSTGGGDLAVVPCKDDNNGPDNYHDAEEPLNGEAEVALAPCEGYAIVCTGPNPGQFENVDPSNNLPAGSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NS69</accession>
    <name>A0A2X0NS69_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C017g08368 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C017g08368</name>
        <name evidence="1" type="ORF">BQ5605_C017G08368</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY19886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NS69"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY19886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="99" mass="10840" checksum="C596DB5E1D77278E" modified="2018-09-12" version="1">MPQADRFRVSHRTFPSDHRRTRISLYQTAGTTALCPTSYACQAVLLLTAVLVGHADLLGYFATQTILITQRASVPGRSSLFVRDALPSKGMPSLPSHLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NTQ5</accession>
    <name>A0A2X0NTQ5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C010g06225 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C010g06225</name>
        <name evidence="1" type="ORF">BQ5605_C010G06225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NTQ5"/>
    <dbReference type="STRING" id="796604.A0A2X0NTQ5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY14531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="166" mass="18449" checksum="3BDA300EE394F728" modified="2018-09-12" version="1">MTVSDQDEIVNADEDVKKTAFSTPNGILYLLVAQQGDRNSTATLHRLVSFAFVRLYNRKIKHYADDLWPISNTKKIRLGESSMQPEKAAGIRATPAPKNKKDLQRFLGAVGYNHRSIPHLAELAAPLDALTGVNSPWRWSRACSDAFETIKAAFDDSAKLTCCNKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NVI3</accession>
    <name>A0A2X0NVI3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C013g07248 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C013g07248</name>
        <name evidence="4" type="ORF">BQ5605_C013G07248</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NVI3"/>
    <dbReference type="STRING" id="796604.A0A2X0NVI3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF133">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY15106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="330" mass="34535" checksum="31F610954EA59C71" modified="2018-09-12" version="1">MSSPQQRLAQVSGAISGSYPQGLLKDEVVIITGSDHRSSTTEVPRLHLAHTPQASPSLEAPSLTACVFSLQAAQGIGKACALTFAREGAKVVVSDLDEKKAQIVVDEIKASGGDAIAVGGDVTADDFPKRLITATIDAYGKINHIVNNAGFTFDKMLHTMTNDAFELILKVHLSAPFRIVREAAPYLRAKDPKVIATNRSIVNISSIAGLHGNVGQTNYATAKSGILGFTKTVAKEWGAFNVRCNAVAFGYILSRLTQAKELGETIEVAGQKIALGIPTGGKKQEGPVPGIPLGRPGTAQEAANGVLFLISPLASYVTGHTLEVTAGNGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NW27</accession>
    <name>A0A2X0NW27_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C002g01334 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C002g01334</name>
        <name evidence="1" type="ORF">BQ5605_C002G01334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY32216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NW27"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY32216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="250" mass="27223" checksum="EF1836BA354FEA8C" modified="2018-09-12" version="1">MEPRSDVEHSTDPFDDVALYQSAVGALQYAAHQARPDIVTSVCAAASKVSAPTQADWIAVKRIIRYLQGTVDWGLKFNHGGSTVFELYSDASWGDNMSTGKSIGAFISIMEGAAISWQSKQQSMVATSTTEAEILAASAAAKEAMWLRRLVADLKLEQPKATLIWKDNQAVIAIALNPAHHGRTKHYSVHHFYIRERVTAGDIRIKYCKTGAMTADIFTKPLARNLFKLHREGMGMVSLGALTSGSVVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NW35</accession>
    <name>A0A2X0NW35_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C012g06711 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C012g06711</name>
        <name evidence="1" type="ORF">BQ5605_C012G06711</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY15951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NW35"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY15951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="45" mass="5000" checksum="79AEEFA8C26E574E" modified="2018-09-12" version="1">MNSALCASQCDWPACYNSPARLPDRAVSILCLLMPLFLFSTTSQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NY98</accession>
    <name>A0A2X0NY98_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g02186 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g02186</name>
        <name evidence="2" type="ORF">BQ5605_C003G02186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NY98"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY39267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="305" mass="33596" checksum="0A7B6C701F4CB1F2" modified="2018-09-12" version="1">MACFHPVIFGDYLAKNLAPVERDDVRWGYILLVRAYDLALGGYLWPRVDGLAKRDGALFGAIMASVSRIGLLVFERAYFLLSTETVSTLFLIDLVSLIAAFSLLPILLPHSVESRPTSSALMRLERHPELIINIALSIGISTFVCAFLGYAVERLGAQQFIKMLETPTVAIPSLRHFLEPLSMPRHIIHSLFLSILTIPFVSIFPTTGSVRLALIAFLLVAPQTATLLWDVLPLHGEAAFYVGAFEGVKAAISSAVTAWTIEELRARRERIETVYAIALIEDEDEKSSLLVVAEGMVEEEPVTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NZF5</accession>
    <name>A0A2X0NZF5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C016g08131 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C016g08131</name>
        <name evidence="10" type="ORF">BQ5605_C016G08131</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat NOL10/ENP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY20708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NZF5"/>
    <dbReference type="STRING" id="796604.A0A2X0NZF5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056551">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040382">
        <property type="entry name" value="NOL10/Enp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056550">
        <property type="entry name" value="NOL10_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012580">
        <property type="entry name" value="NUC153"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23098">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23097">
        <property type="entry name" value="NOL10_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08159">
        <property type="entry name" value="NUC153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nucleolar protein 10-like N-terminal" evidence="9">
        <location>
            <begin position="9"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleolar protein 10-like second" evidence="8">
        <location>
            <begin position="385"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="NUC153" evidence="7">
        <location>
            <begin position="528"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="487"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="546"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="487"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="498"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="565"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="647"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="672"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="716"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="768"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY20708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="789" mass="87124" checksum="EB86346CE0FEA4D2" modified="2018-09-12" version="1">MLENGGSKAVKDFEFPEASNKIKTTSDGQYVVATGTYKPRMKVFDLQELSLKTERVTDSENVDFCILSSDWTKTLHLQADRSLDLHTQASSHYRVRMPKHGRAVAYHFPSCDALVGGQGNQVWRLNLEVGRFMKPYGLEGCTSELDGGEGGVSGDGLDTVLGVNAIDINPAHQLLSFGTETELGRGTVEMWDPRSRVRAGILRLPYAKLMAASGSSAALLQPALPGVDDPSTGGRRGVAVTALSSKSDGLNLAVGTSTGHILLYDLRAQREYTMKDQGYGLPIKKAQWVDEGVGRGNAEGGYVASVDEKVVKIWGRETGTNLISINPPVPINDMHVYPSSGLVFLANETSPMTGYYIPQLGPAPKWCRFLDNMTEEMEQDQEALLYDDYKFVDRQELDALNLSHLIGSNQLKPYMHGYFLDLRLYTKAKAIANPFAYAEHRDRLVRERLEQEQESRIRGAKKVSGANGGAGALPSSVKVNKALAKKAQEAERKREPIAEGEDIEMEDGERRKKKKKKVQAETPSLLKDDRFGDLFVNPDFEIDEQSREFALLNPSTKPTVRRQEDDEDEDSDDDDEEEDDDEDKGEDGDSDSSDEGNLGFDAPRRGAKALPTSRVSTKDIQPVRRGMPETQSKPSLVVADESDDETPSGSTRSGSQTLSSHQAKQSRTFGQRAREELSSKATGKGREVATSRDDSFEVIRSAPGGGMEMSFIPHAKTKEEQLIEKKEKKHKIEKERKAKASFGMGMETSSGPERIQEELEGEQESGRTRMRKPMRSASKGKIRSVEGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NZY5</accession>
    <name>A0A2X0NZY5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nascent polypeptide-associated complex subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Alpha-NAC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C019g08893</name>
        <name evidence="7" type="ORF">BQ5605_C019G08893</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAC-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY23080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NZY5"/>
    <dbReference type="STRING" id="796604.A0A2X0NZY5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005854">
        <property type="term" value="C:nascent polypeptide-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22054">
        <property type="entry name" value="NAC_NACA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016641">
        <property type="entry name" value="EGD2/NACA0like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21713">
        <property type="entry name" value="NASCENT POLYPEPTIDE ASSOCIATED COMPLEX ALPHA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015901">
        <property type="entry name" value="NAC_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAC-A/B" evidence="6">
        <location>
            <begin position="23"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="97"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY23080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="172" mass="18680" checksum="F6304C4A673F16D7" modified="2018-09-12" version="1">MSHAEIDTDSHITVEQIGEGTRSKGEIKSRKALSKLGLVAVPGIKRVVMRRPRQQLFVIADAQVFKSPSSDCYIVFGEGKYEETGTRDSEFARAMQQTEMLERQQQKSAALPPSSEAGQVAGDGSEDPEGEDGLEADEIKVVMEQANCSRAKAVQALRSTKGDLVQAIIEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P1H0</accession>
    <name>A0A2X0P1H0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g03937 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g03937</name>
        <name evidence="2" type="ORF">BQ5605_C006G03937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY54951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P1H0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY54951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="78" mass="8543" checksum="26BE8860220C1B4E" modified="2018-09-12" version="1">MLTRIFAAGLSNAIDLRIVAPSLVTVISPVEVECKILFMPLGPRVDLTRSPRARAPTKDERRACVGTAKRRKSEVSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P1H1</accession>
    <name>A0A2X0P1H1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01358 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01358</name>
        <name evidence="2" type="ORF">BQ5605_C002G01358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY32390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P1H1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY32390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="71" mass="8175" checksum="95A9CDB2F045B9D1" modified="2018-09-12" version="1">MTKTNRRTKTATMRMKTARKGTKRMVMANDEGQVKGSRWRVSRSQFFAHYLPNATSTSQSRIAPNVPSWRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P1T6</accession>
    <name>A0A2X0P1T6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C002g01449 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C002g01449</name>
        <name evidence="5" type="ORF">BQ5605_C002G01449</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY33107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P1T6"/>
    <dbReference type="STRING" id="796604.A0A2X0P1T6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058855">
        <property type="entry name" value="RGS1/SST2-like_Fungal-DR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF192">
        <property type="entry name" value="DOUBLE HIT, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25889">
        <property type="entry name" value="WHD_Fungal_DR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0734">Signal transduction inhibitor</keyword>
    <feature type="domain" description="DEP" evidence="4">
        <location>
            <begin position="246"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="460"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="576"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="641"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="386"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="655"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY33107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="678" mass="74041" checksum="14C25CFC4142D905" modified="2018-09-12" version="1">MASTASSSQPTAGRQQQSSHMLKTGRRGNPFCKMADTHDLFATLMVSLDLSDRTRFFRTYPNAFTTDDAATNLSSLRFSQSNRTSDPVDPQRIVTTTTTTTFSMSRDIAKGICQHFMDARLIENAADPSSLNFKDRGIYQITPKGLHILERFITKNGISADHLVPVFTSQPICMKLLHLERRTSDDEIHISRSVIDVVFRRFAGGRHPNYINEPHDPRPVVGSIVPRPFVDNARPPPGFDRAGGVELQDVTEKSKAGQPVVVKQVFLSTHGIDWLVDYSTCCCREEAGELMAHFVRYGLITLYLDRSKTGDRVTASEAKGTISGEAEYRQGAKILYRITDDGRRAAATPGPVSQPAAASSTHFIPLNEAAPPLSKPALLKVGSTKMEPKVSSEGKSDSDVDSQTDFDRVVDTTFVGGTGLSNVSESAFVGKKALADLFKSDTSDAAVAGWSKDQHSTTTRLRAILDEPALRALFRDFLRANYCDENLAFWIDVTDFRRRFSTTSSAVGGAAQQAAKRKQGAASNAMETHQQNLVAAALHIYHTYLAPLSPSELNIDHNLRADVVNYVNRALAEVAPPSNRPVTSSGSSGDDSDMIPALRATQVQTLLRQYERIQEHIFRLLATDQVPRFVRTEPFLALMEPEALKNDAPSSTTNSPDLSKPPLAASPALGAGPPVPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P245</accession>
    <name>A0A2X0P245_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g04217 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g04217</name>
        <name evidence="2" type="ORF">BQ5605_C006G04217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY57075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P245"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY57075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="163" mass="16977" checksum="7FDAF062736756A5" modified="2018-09-12" version="1">MPMPTAPSHSPTYSRPAAASAAPHVATAATGHSPITGGPRPVARLTVDERAYLDQNHGCYRCRTLNADHISRNCPRYLSPMGASATPSTPTSTAPAPRPGPRMVAAIRTFQETGDSTVFAGLSSDSEDDNDPSYAPHPFPPLPVSLAGAHGTLLASACKARLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P259</accession>
    <name>A0A2X0P259_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g04237 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g04237</name>
        <name evidence="2" type="ORF">BQ5605_C006G04237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY57192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P259"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY57192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="860" mass="95335" checksum="594DF5D98C7868E5" modified="2018-09-12" version="1">MRTRIASSVQRDEGGAPPMFSASRTPRTAIALSDITNNLVDTKPDLSAGKKKVPAGAHQRAPSNKAKPSKAAAATASDAKPVKPVEPVKLLKLEKPEKSSGVDAVAEDDDSLHASTHSSDGDLHEAGHRLDALTTSDNESEEEKSPLGSDSGGPETESDHLQQPLKKHTSQASSKRQRNDTPDDLSDCSEDNLPLFQTEALSIFSTALATARSDLHKLIGRVQRKEVDMLRAMQSWYKDNPTTYTDEHLAWWSVLVSHRIAELRSSLRAYTSRASIDPQRLVEQTDVERGFADNKREFWLHLSGFATTLAKKAAQRFYHARYCPNGAFDYSIFLYRTVVSQFYDADTSPMTTRPKVSTMDSTFQAQCTTVITTCQPVADFQRLVLLYQQNCWIAYGDVSNTRIYMGLLREPPFDRRGTRPASSKLARLRSTTLLHEFARGLRARKPTWAPGGHPMGAMNFTQQCVGPELETLKMRDLRMVTSEVIKLVAPIWRMNAFTYLTSRVQPLARPPFVPTGGLRELLADGHVSAEFMFAITQHCPLLETLVIEPWVVTINHRPSVVQLNMAQFIQPLNPVAMRNVYWGGGMPLTQAAASVYNSILDILPRLQELGVPLQFFSLVLAQTLSDNKLQRLTLIPSSRALGGIDAPALAARLEEIVRALGIAMIEFSSSGVEWEARNGIDSFIGYEGVKRMLALAKARLDAGVQYEAPSAAKAGPTTFQDEVKQEYAEECQQLWQPRVETRQSAAEVIHRILGFLFAQAVEEDGPDYSDRLLCPNVLRQWCRMTISLLYRDVYLTSNLQVDAFVNASYTKLGTPDPAFAPVVHNVGIDDDPEMINKRRRTAGPGVEPGPLHCCQAIAMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P6W0</accession>
    <name>A0A2X0P6W0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C001g00796 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C001g00796</name>
        <name evidence="1" type="ORF">BQ5605_C001G00796</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY49598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P6W0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY49598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="43" mass="4875" checksum="FE0AB8CA202DF934" modified="2018-09-12" version="1">MVWWKGVSWASRVEQVLCGLDAIRQGACTIGDRKFSCLSRGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P7S9</accession>
    <name>A0A2X0P7S9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">BQ5605_C006g03862 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C006g03862</name>
        <name evidence="13" type="ORF">BQ5605_C006G03862</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY54290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P7S9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015183">
        <property type="term" value="F:L-aspartate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043490">
        <property type="term" value="P:malate-aspartate shuttle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051028">
        <property type="entry name" value="Mito_Solute_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678:SF1">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="16"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="117"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGY54290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="270" mass="29656" checksum="A44E4FD9561359FB" modified="2018-09-12" version="1">MSSNDSTPVARNRKPLPFVYQFTAGAIAGVTELLCLYPLDVVKTRMQLQVGKPVAGAEHYNGMVDCFKKIIAREGAGRLYRGLVPPLMLEAPKRAVKFAANDFWGNTYKSALGTDKMTQGLSILTGCSAGATESVVVVPFELVKIRLQDKNSTYKGLMDVVGQIVRKEGLLGLYAGLEPTFWRYVDPREPLLLRLTCFASPLRFSHVTWNGGYFGCIFQVRALMPKAKSKSGELFNNFVSGAIGGFVGTAFNTPFDVVKSRVQNSIKVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P902</accession>
    <name>A0A2X0P902_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C006g04261 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C006g04261</name>
        <name evidence="6" type="ORF">BQ5605_C006G04261</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY57357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P902"/>
    <dbReference type="STRING" id="796604.A0A2X0P902"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039757">
        <property type="entry name" value="EIF2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041366">
        <property type="entry name" value="Pre-PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058886">
        <property type="entry name" value="SWIB_eIF2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057429">
        <property type="entry name" value="WH_eIF2D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17832">
        <property type="entry name" value="Pre-PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26291">
        <property type="entry name" value="SWIB_eIF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25304">
        <property type="entry name" value="WHD_eIF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-PUA" evidence="3">
        <location>
            <begin position="2"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="eIF2D winged helix" evidence="4">
        <location>
            <begin position="303"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="eIF2D SWIB" evidence="5">
        <location>
            <begin position="444"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="SUI1" evidence="2">
        <location>
            <begin position="554"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY57357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="647" mass="70385" checksum="B0855EC05B8855E9" modified="2018-09-12" version="1">MFKRPFSSKTSTPVRSSDLRRLREELVQSTSIPKSFFFPSLDPAGWTSALAKVALPDKTLICKAATHLDEPVTLYLSPATGNDPLFFRPGKGDDHDLVPTCYAIDLLQQPHNQTLQTLQRQNAIKSPGRYVLPTLVTADATSGRGYFSGASPTPTEIPSSDRNHLSKPHAPSALFLAGISRSSLLSLPDEIQPGSLVTIRCSSSPVIVAIGYLTATRPELLANFDRNKGGKAVTTLHARGDFLWNSGSKESVVGATSLSWPHGSAGTAKDKGQEVPLRQMQDLSVQPKAGERAELAPADVDVVLLQALLLSIRQTLSKPTAPFPLPASSLYSSHILPHRPASPPHSTVEIKKSSHKKLSAFVKFAVKAGYVVSKEVKGELMIMSVHVEHPDVQAVRIYKTLAQAQAQAVQASSKKSEADLGPGGSSLSEISSSSSSVVITELFKPTSDVLAIFQDVDHPRPERDLYLPVELKKILTTYITSHSLTHPRDPAFLTPDETLSHCLLKKSESLDLLKRSDAITRFQSSCQTYYSVARPNHPVESFKGTPPAMKIWVKNVGKRQVTILTNHETYTSTPLNFYPLQTLLDELKMRTASSVSLQPILGATKKGQAQKMEVACQGTHDKVVVDMLTSKGVPRRLIVVDLAKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PAU2</accession>
    <name>A0A2X0PAU2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C035g11427 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C035g11427</name>
        <name evidence="1" type="ORF">BQ5605_C035G11427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000064">
        <property type="protein sequence ID" value="SGY97822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PAU2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY97822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="187" mass="20517" checksum="418CB2E08351D592" modified="2018-09-12" version="1">MEVMSDTRPPAFQLFYSVCSVTPLSLASHHLIAADVWHNHTSPSSGVISGYELHTRYQQSRVGIAKGLRVRFTGANAPLVIFSQLHLISANAEQYALHVTLAGSQPLVESIHCINQSDHSALSTKMDYPLTEIRGGILMFILFKRGVECIPRNEMMASRRVSDRAGSCLATRVLPTLPTSANSRLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PB02</accession>
    <name>A0A2X0PB02_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C004g02836 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C004g02836</name>
        <name evidence="10" type="ORF">BQ5605_C004G02836</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY67996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PB02"/>
    <dbReference type="STRING" id="796604.A0A2X0PB02"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015343">
        <property type="term" value="F:siderophore-iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000197">
        <property type="entry name" value="Siderophore iron transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF92">
        <property type="entry name" value="GLUTATHIONE EXCHANGER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="543"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY67996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="596" mass="64796" checksum="98F1A661F4B3B30F" modified="2018-09-12" version="1">MATRTSSLDKTSQAEAHGPSGGDSLHSDLHLVDESAGVQKITAMSNEIDLPLRIFLFIGVFVISYAYGLDGTIRYTYQPIATASYSQHSLLATINVLRSIVAAAVQPPYAKIADVFGRFELILLSIVFYIVGTIVEATATGVKGFCAGAVLYQFAYSAIILLVEITIGDVTSLRSRLFFSYIPAVPFVINTWVSGDVTQAVLAKTTWRWGIGMWGIIYSVCCLPLLAALFIANRRAKTNGSKSGVQTLYQRLGFRKLVVHLFWELDIFGLILLIAAFSLFLLPFTLAGGETRTWGRPHIIIMLVVGILCIPAFVLWELRFAPVPAIPFKLLNNRTVLSCLGIASLLNCSWYLQGDYLYTVLVVACDESIKSATRITSLYSFTSVLVGVALGIVVRFVQRIKPFMIAGIALYAVAFGLLIRFRGGTESHAGIIAGQVMLGCAGGMFPYPAQALIQSTTQHQHLAIITAMYLAFYNVGSALGNTISGAIWTQVLPGKLARELAPFNNSTMGADVYRSPFEWIAAYPVSTLERQAVIRAYQGTQKILCTVGICLVVPLMCCALLTRNTKLSAAQSLEKPAEGDRTIERAVLEKDGHALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PB75</accession>
    <name>A0A2X0PB75_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C034g11352 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C034g11352</name>
        <name evidence="2" type="ORF">BQ5605_C034G11352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000065">
        <property type="protein sequence ID" value="SGZ00499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PB75"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ00499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="55" mass="6055" checksum="E46DDB335CF816CB" modified="2018-09-12" version="1">MIITQTAGKMRETGQVHQSDTSDSSAQPSGCSPPSQETNEREKETQREKGNQLAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PBM2</accession>
    <name>A0A2X0PBM2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C004g02955 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C004g02955</name>
        <name evidence="1" type="ORF">BQ5605_C004G02955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY69087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PBM2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY69087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="79" mass="8720" checksum="4CE78986DC5907DF" modified="2018-09-12" version="1">MLCLYRSCNEWLAFAFFFFFLTGAHKLQSFGLAGTATKRAKGGYKATTASSWVKVKPLRAKSAAQIKTRRAPNADSNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PDV3</accession>
    <name>A0A2X0PDV3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BQ5605_C020g09190 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C020g09190</name>
        <name evidence="11" type="ORF">BQ5605_C020G09190</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DOP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000082">
        <property type="protein sequence ID" value="SGZ18571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0PDV3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040314">
        <property type="entry name" value="DOP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056457">
        <property type="entry name" value="DOP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007249">
        <property type="entry name" value="DOP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056458">
        <property type="entry name" value="TPR_DOP1_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042">
        <property type="entry name" value="DOPEY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042:SF24">
        <property type="entry name" value="PROTEIN DOPEY-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24598">
        <property type="entry name" value="DOP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04118">
        <property type="entry name" value="Dopey_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24597">
        <property type="entry name" value="TPR_DOP1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DOP1 N-terminal" evidence="8">
        <location>
            <begin position="100"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like middle TPR" evidence="9">
        <location>
            <begin position="422"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like C-terminal" evidence="10">
        <location>
            <begin position="1399"/>
            <end position="1890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1499"/>
            <end position="1519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGZ18571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1913" mass="211678" checksum="22261CD6450A7671" modified="2018-09-12" version="1">MSAPSTSTSTSFSSPTVSTVVATASGGRVGAGGAGAEAGTRRHSTRVKETFAALAAQEKVLLHLPLTRHASPPTQRTRTSHTATATPSRLFALLTALASDPKYRKYAQSVERTLQSFDQVNEWADFITFLAKLLKCLQAYPQFVVIPHKLIVAKRLSQCLNPALPTGVHQRALDVYTHILTTIGPENLRRDLPAWSSGIFPFFQYAATSVKPIVLSIFERFYLPLQESLRPATKAFILALLPGLEEETGEFFEKVREVANIALAGLGTDGLASILIAQVAALLDRVSGAVSPSFFFQNVWLVLVTAPGSRIPALNYLSRRLPKLQSEDGLTYIVGQDIGLMIRGFSAALEDAQILVQRGILDLLTATLKLDSRGFRATPRQDQVLLMRSVLGVVLRRDLSLSRRLYSWLLGTNEGSEAQVAYLKEHGLELVREALKIDMDAQSVDSVDRQRPFKIFISLLDKWEIGAALTEVLVLDAFAALKVALRPNDDHDEFTRPSQLLMTGNMLFEILDPFLMWKAIYFSMRSSVVSACSAGSRSDLSTIELVRFIVATFRLHDEEVQKLHAPFVAFGLIDLVEQALTGTLQVEQGLATRAVEPDRLFLTTILQFVVELIKEVSPHFYDSNDALVVLDPPEDPHLGQTLADLLYGATDMKTASLPETEGRELLASGLASTTRVIQACVEPNPRLGDAQSRYQANGGKLLLDSIGVLLSLYVVTESLDTQIKVAWEPETWAKSVVGALERTETTMANWGIFGCVVWGLSTVMTSKNVKPTLKRNRRDLLEAIAAKLLEYLQPSGAPCFVEAVQMLWAIESFSDYRLLETMISERLASPDPAVRLAAFEAFGNLWRFTEDSQLPGVVLRTPMFRMLDSLKADDLSTRRAGEAWMRCSLKSYLRILDPLLFTLLDPSIEQRSTIIKVADLRVPILEYEATFDQARVHHVLDCLLGLARFGGQGFIRIAKGSFMKHSLDPSFRERVRAADLDTHTYLDGLIIILVRFLRAEPNPKLVPSLGPLNYHIHSVVAELLQVVMSRGEAEITGLSTIESALTSRLYLCVHRGELDLQNKLLHVLHSVVHAVAGSNARRHRRAPSVASTTGTLIATNELSNEAQPPDMTHDAMFVRVVSDGVTTQNNNAVIHHWIDFLLMTIPQFRQSLHSVLFPLIDCLVQRLRSFVGDFERTYGVDRSELIKPLTSATDAEFTVLVNALERLLLIAIAESNAVAPDEEPKASTAMSSDASAGTGLLGYMSGVLGSAEVEVTEVSEATKTKHAALLRLRDCVVMLLQSWDVSTRLEILAGDDVSTSMGHFAARAKLRARKALERIYKSAPSDSLDDIAAHWQKLKDSESEARVFEMVGILAPSAQSVVSMICDKLGPLSKGATSSNQHDKNRSPYLASDELLFAFLEAYLDRLDGAISMQVWSTCLGLVRDCISNISTSRPHIFACLRCFTTLSEKVSQTSALEDRRMRRDLQETFIRLADASIQLAGRSVDQSGWLRKGRTERLNGEADSAMSKETKETEDVTDEEKRALAATPSNHALDITDFLAHRVLPDFRRFLIDSDKTAATCSNMVYYIVAPAFKTRSKTFEVEPAVFSLLHEMVKNPATVKAWKTMVGDAFGDNRFFNAPPTADAHWRPVIQAFVASDKERLVELTSKISSVSSANIFTNRELENLSRALSLRRLTYVLFTGDKDRFLTQLPMIQEKLVDLLRSSVGDMVHAEVYLCLRVLFVRIGNQHLSGLWPTILTDLLRLFDSLVEQSVPDKSDLLQLVHSACKFLDLTLVLQTEDFQIHEWMFVTDTVDAMYPPDSWLPQAIMDRLGEIIHDGRFAPSSPSASISPVVTRGGGVGTDSESTAAWASDRITPRRTMLVGRRVNTIGDLIPFFSTVSLAAYESVYGSGGRIDHEAVEKGLARDLFDFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PE43</accession>
    <name>A0A2X0PE43_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C008g05219 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C008g05219</name>
        <name evidence="2" type="ORF">BQ5605_C008G05219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PE43"/>
    <dbReference type="STRING" id="796604.A0A2X0PE43"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17657">
        <property type="entry name" value="CDC14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029260">
        <property type="entry name" value="DSPn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14671">
        <property type="entry name" value="DSPn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dual specificity/tyrosine protein phosphatase N-terminal" evidence="1">
        <location>
            <begin position="82"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY79777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="251" mass="27813" checksum="B186244663B8BFC4" modified="2018-09-12" version="1">MGRHPSRTPSIDADGDSLISLATTTTSRDLDEHEGALDAAGADQAGSSLFAQPIGPICAYGPRLAYTYFNSPVPRAEALNAVQDDVHFFTVDDQLLYLSFFQDSGPLNAACLYRFCLHVHTLLENEEYANKRIFLYSSEEPDKKANAALLIALYAVRTHFLSHVVPQQCVFAPSHDNAITARVDRRVDREEKIDYPPPPSPGWTSIQPMRAVGVCSGLVMNKGPRWRNRMDVPPPGWISLIVVLEKEGFWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PEI7</accession>
    <name>A0A2X0PEI7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C008g05379 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C008g05379</name>
        <name evidence="2" type="ORF">BQ5605_C008G05379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY80409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PEI7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY80409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="628" mass="70046" checksum="0AD2B92EB78CF2FC" modified="2018-09-12" version="1">MPQLRIVVPSGLNEVLAYKFPANAYRFVPHEPHERLSSESRLTTPKPSSTSLSRLTTFRRSPGEELPRYPLTSASHDHSLVDRVGQGLKRGLQSSRTGLDTPLPSFVNSWFDDFLHWRPLTLYETDNEFAKSHLGDLIRGVIRETVSRLADRPVTISQIFSIHKYLGQDGLPTLKAWVRGDSFDNKIAFEVNSVGKLESLDKVLVREQKPKLWLGFGSGCPIDLHIFDSNGRSMTLSESEGMRLAKMSLQLYQSKARFGVFYAPPYFVLCELVIENGRTHLLTSEVCSSALLPDEDLPTGAAPRSESLFSTLVSLFLSAHADYPIEGPPEEIRSALRRTTEKLASTPSAPVQFPPIRPALDDVAGPFLVDQNAPVSLRHVPGTAVICGSEASKDTGMFATRVELECDGDVSRACPFGHALQRRYFTDQSSFHLLQFFSADFDENKAAESLPWVRTPVGDRARLDRLDLVTELGRSRTATGWTARWSRRLTAEVPDASASNDAPARLQGGLVAKVVSAEYAPSIAREYFIYTQAVPSLSTAAQAYFPKFHGLYRSGSDGRAYVLLLEDVGRKVTREQWEAGTELRRKTDEAFKALKDEGVYHDDQRYPNVTIRPDDRICLIDWGLASFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PF02</accession>
    <name>A0A2X0PF02_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor IIF subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">TFIIF medium subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">TFIIF-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C023g09664</name>
        <name evidence="13" type="ORF">BQ5605_C023G09664</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIF beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ23929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PF02"/>
    <dbReference type="STRING" id="796604.A0A2X0PF02"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07980">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000035">
        <property type="entry name" value="General transcription factor IIF subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003196">
        <property type="entry name" value="TFIIF_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040450">
        <property type="entry name" value="TFIIF_beta_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040504">
        <property type="entry name" value="TFIIF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02270">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17683">
        <property type="entry name" value="TFIIF_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIF beta subunit N-terminal" evidence="12">
        <location>
            <begin position="46"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIF beta subunit HTH" evidence="11">
        <location>
            <begin position="286"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="96"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="351"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="388"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00081473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGZ23929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="404" mass="44566" checksum="286772654EC7D926" modified="2018-09-12" version="1">MSIPMNALPAEFEAEHGSIDLADPDSNLDDEGADEEDDLDLKQSQRSVWLCKVPKFLLDKWEQVQQEGVVLGRVRVYDEKDANGDPKIAVLLEQDESSAPSATATAPAAAPAPSRDIKGKGPIGRRNGTVPTEYHLRLQNTSSKNLFIFGEKEEEDESTGDVGFRKKRRESREDVLAISWTKYDAHPTLRSPGITSLAGTIQHECQLTPSLSSISASDSYRTIMRERQRLATEPKRTIKMLDVDNATANRLASGVGMSGVKHRVASMVKTAKAAAGSGAGPNGRMVRMPRNELLDLLFQHFDQAPYWNLKLLNEHVKQPATFLKEVLGEVGTLVPRGPYLGMWTLKEQFKSGNRDENAKPEGKDEAHVAKNEEGVEGSSTTDVRKAEDDPDEDDEDEDEMEVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PGZ9</accession>
    <name>A0A2X0PGZ9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycerophosphocholine acyltransferase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BQ5605_C037g11638</name>
        <name evidence="16" type="ORF">BQ5605_C037G11638</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GPC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000062">
        <property type="protein sequence ID" value="SGY94229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PGZ9"/>
    <dbReference type="STRING" id="796604.A0A2X0PGZ9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021261">
        <property type="entry name" value="GPCAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31201:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31201">
        <property type="entry name" value="OS01G0585100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10998">
        <property type="entry name" value="DUF2838"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="173"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SGY94229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="574" mass="64620" checksum="E2CC5F9ECADCAC3F" modified="2018-09-12" version="1">MTDPTHATLRRRKDEPLDGAQASTRQEIAVGDAESSSTAPADATSSSPSSEPSTPSSPSSSHHQPHYGAPLRPTLSRSATNDSPTASFELSDDEPIFSGLPLLDLFVLVDAHLELWTRGIRRKSADWRSKADKLVEESKSRAQRIKLPRVASETFLNGMRSEESNGVLSSRDRERLEKRVREVRANAKEQMRRLNQKWEQEKTVRLRDKISFFSGVMNVLISALLLGFEPTWIPAWYSAQVMAYLPLRVYTYKKRSYHYFLFDLCYAINGLCLVYLWILPGNVFLFQACYGLALGSLGTAIATWRNSLVFHSLDKVISLAIHIFPPFVFTTIRHFYPNAEARYPALVHLPDLQSWSARWKSMAVCMFTYLIWQALYFQYIIVARKEKIKQGRATSFTFLINDRKRLIGKIAAKVRPERREAAFIFGQAVYTLVTLLIPIFGLYDSKFWSSIYLLTLFAVSVWNGASFYMEVFARKFEKELIALRREFEAQQEILSKTSSGILGAGSVDMSRSASQADLPTTVAEVDDEVDEREKADGAEMDGEASGVLVEGVAGQDLVMVDKEATAAHEAADRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-11-27" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PID5</accession>
    <name>A0A2X0PID5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit F</fullName>
            <shortName evidence="4">eIF3f</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C030g10845</name>
        <name evidence="6" type="ORF">BQ5605_C030G10845</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit F family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000069">
        <property type="protein sequence ID" value="SGZ09138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PID5"/>
    <dbReference type="STRING" id="796604.A0A2X0PID5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03005">
        <property type="entry name" value="eIF3f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027531">
        <property type="entry name" value="eIF3f"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF6">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="5">
        <location>
            <begin position="21"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGZ09138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="323" mass="34565" checksum="B9E8655C14017726" modified="2018-09-12" version="1">MSLSLALPSTSLASTRPVSKVVVSPLPLAAMLDHHLRRSSSQDRVLGTLLGIRHEASNEIEVRTSFGVPYQAQGKGSITIDMDHHKALLDLHHKVNPREVVVGWYATHPTLNSFSALIHNFYGSESSPFPAVHLVLDPETLAFASYVSTPVGTTQRADQVAFVPVPTELRVHAQERPGIELVTSNLTSLKSSAATASSDTTIDPSTTIALTTPLATLLTLLEKVSLMLDSVLSYVHKVNLGQIKPNEKVARALLETVGSVPVNAVTSLSKSSSSSSSNGNANNASTSFEDEFNAHLADVLMVSYLANVVQTQTEISSRLNLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LPK9</accession>
    <name>A0A2X0LPK9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C011g06613 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C011g06613</name>
        <name evidence="2" type="ORF">BQ5605_C011G06613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LPK9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY12809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="407" mass="44318" checksum="220FEE36FF28ACF4" modified="2018-09-12" version="1">MNKSSLLSLATSSSASPTINAGNTVPQIGPTTTRSKQGPTVQPVEDPNESDDESFTIDPSLEDIMLEEERAPDPANFSDNIGDESDSSLEEEASAHVAVIAYGPAEASSVTSNLVVSKSSHLAPPSIMDDDSEIVISGATAQPKGQALQSSIAGRSLLRPHSKGDHAKRTPSSSSSITTSSTLATGPKDLFAPYDGAHNTKSIVQEFSKPKRQRHRSDLTDQEKKVAGLWFQKMFLENILDGQGIWRSKRSLYDQSETFADEYNKSGRTRIEWSTKIADLAWIATNSGNCVLNIIKRAVLKCTYKAYGLDPERLPAAAAEKATLYLENTRWAAKELRCGAGARGPNLDQCTFEPEEDLQNDLLYEILVQIVAGNMRDRSAALQWPERGLDPSNEDHRELAFALVTHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LTG1</accession>
    <name>A0A2X0LTG1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C015g07853 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C015g07853</name>
        <name evidence="9" type="ORF">BQ5605_C015G07853</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0LTG1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11883">
        <property type="entry name" value="SH3_Sdc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056685">
        <property type="entry name" value="DUF7783"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF354">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25006">
        <property type="entry name" value="DUF7783"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="8">
        <location>
            <begin position="884"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="7">
        <location>
            <begin position="1069"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="157"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="638"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="738"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="643"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="661"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="790"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY17667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1364" mass="147643" checksum="9F7B8BB856F09FA0" modified="2018-09-12" version="1">MSAMEQATARAGSPSTVASSSHAEYCRALHDFSPQHPSTCLAFSKGEVIRIFGKDQSGWWDGELRGTRGWFPSNYVQVQIAPNTISSTAVASPATVDRRVSLSILAQPSPAIAVRAVTSCGYGLELGATPTAHVAKCAKQCAYLCCLLQSTPKLPPKEEQSVAYGSRSHSSVAFGHRNSGSREGLGSREDLGPRDSATTAFPERGSTLDTVATTEQIAGFTTCTSPKLEQRATAFERESQTLVAEVQNAVTLVQAAVNAQRVPHYQPTTACVISSVRTVLASSDCLTRESPFLKCSSALATCRKKILASLASLVNQARRASSPSTTIEQSSLDAQVMLDVARQVAKQVDNFLDEARVQGLPLIPTERLVDDRRGSPHMITPPLSASNLLEAHPMRVAKSAPLSTLRIARSNGDLKAHRAVQPPTPLQLSPIKDFPSTGQSFLNIETSPKDLDVQSPSSTVQVVHNGNELASILSKIHDILLSTIAALIGHVHAHSRSAPAASFARLIDITREIIEHIRSILLIVEAVTQHPTLLTVKSDESSASSNGLKAEVDNLAACRDRLYVATTALVTAARVASSVPAKATSAKILAISREDEERKDLLQAATAVLRAGGDTVSAVRLCVGYAGEPNFTLLIGNPPPTSPTALSSPTTLTPPTGPDDGATRRPEFVGRRGPHTLSMLGRKATSLSCLTGQYDSQTVTGTLERFSVEEEDETVAYGRDGEHVEAHVSGLTVGGIAQGRARKESASSGDETVTSKDLVGRRGPQQAGETYLAAAGMGAGSPPMVRGDSSRTSQSCASSRSGVSTVSTNDSSPRSSTSTAHTEPSSTLAKAGASIESFAPMSLGLGGSSRISVHSSSGKSSSDQSTTLWFLERNYEAREISFNADGRVTGGTLRCLVERMTLHDTTIDPLFSNTFFLTFRMFTSPPQLVQALFARFDIAAPQGLDETQLKLWNSKKLIPVRLRVYNFLKTWVESYWKVDQDLIVLEPLRLFCQTRLAKAMSNPSARLMELLNKRERGTDVVRSSTPGGVGPLPQQALAGAPSPIVNKSLLNSIKFMAVNAQTFSIVDVDPLELTRQITILESRVYSCIGVEELLSGDFAKPDGFIRQMSTMSTKLTGWITETIVNESESKKRTTLLKYFVKVADQPLIAKLSFPQRCFQIKNYNTLFAVLCALNSSTVARLRRTWDALAPKYRVLLDQLRKATDHARNYAEYRATVRQAVPPCLPFVGLFLYVNSGQRFLHHFAYEYSFFDAPRTDITMCSEGNPPFRPSPVDPSLRLINFDRFQKMSRIVGDLQRFQVPYNFFMVPELQTLLTRALNDLTHGGDAASLYRQSLLVEPRNVQSSASSAISGNNLSKGSDSFNWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LU64</accession>
    <name>A0A2X0LU64_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C014g07528 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C014g07528</name>
        <name evidence="3" type="ORF">BQ5605_C014G07528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY18987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LU64"/>
    <dbReference type="STRING" id="796604.A0A2X0LU64"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015855361" evidence="2">
        <location>
            <begin position="23"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY18987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="310" mass="32479" checksum="85EF496223CBBF10" modified="2018-09-12" version="1">MHLVTVLPFALVAFLGSTGVQALIKTANATLEALYLVEYDTKAYGTPETGAVKHFGTNFHQACVAAAIQKNSHHALSLIPYQDTNTTDISTPWVYANCGGRLKRRDGTWDNHGPVTDLVSLLQLWPQVTTRAASAVTDVPQFPTSQMDLAMNNTLFLGNARIVSGPDGKPYAPAYPPPTKPTPETRDADAASPVPDSTELVPGTTLPGPSTIPGPGTTPPGPGTTLPGPSTIPGPGTTPPGPGPTLVPVSRPTTPLTGGHGRKGRKHRNGRKGGFKRVQVTVDDTVDDFLMNGQVQPTDSVDTLLGGIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LUB2</accession>
    <name>A0A2X0LUB2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dynactin subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C010g05877</name>
        <name evidence="7" type="ORF">BQ5605_C010G05877</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LUB2"/>
    <dbReference type="STRING" id="796604.A0A2X0LUB2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03359">
        <property type="entry name" value="LbH_Dynactin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047125">
        <property type="entry name" value="DCTN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126:SF1">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21711">
        <property type="entry name" value="DCTN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY13499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="201" mass="20960" checksum="F00BA6471A7EA5A9" modified="2018-09-12" version="1">MPPSTPISSSSSNVPSTATRPSKSDYIETDTGNKVSRKCVISGSQNIILGGKTLIQPGVIIRGDLRRAGATGAAVVVSIGKYCVLGEGCILRPPAKTYKGIFSYYPMKIGDFVHIGAGSIVEAATIGSGVEIGKNCIIGSMSIIKDNAKILDNSVVGPGTVIPSLTEWGGSPALILDQLPESTPELTEAKSKSFYAKFQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LUC4</accession>
    <name>A0A2X0LUC4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Dihydroorotate dehydrogenase (quinone), mitochondrial</fullName>
            <shortName evidence="11">DHOdehase</shortName>
            <ecNumber evidence="4 11">1.3.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C013g07130</name>
        <name evidence="14" type="ORF">BQ5605_C013G07130</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>(S)-dihydroorotate + a quinone = orotate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:30187"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="11">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.2" evidence="4 11"/>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY14850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LUC4"/>
    <dbReference type="STRING" id="796604.A0A2X0LUC4"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106430">
        <property type="term" value="F:dihydroorotate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04738">
        <property type="entry name" value="DHOD_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050074">
        <property type="entry name" value="DHO_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005719">
        <property type="entry name" value="Dihydroorotate_DH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01036">
        <property type="entry name" value="pyrD_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109:SF4">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00911">
        <property type="entry name" value="DHODEHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroorotate dehydrogenase catalytic" evidence="13">
        <location>
            <begin position="357"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="30"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="79"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="218"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="786"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="911"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="786"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="814"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="840"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="917"/>
            <end position="946"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGY14850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="946" mass="100093" checksum="F56882490AD3ED46" modified="2018-09-12" version="1">MFRLGRRSLTASRARHAVLSPTYFTRHSLATLPTAPTHPPTPSTVKSSSTSAPCPPAQPVHHTSPTTAAAEVEQLTHSNVSPVGTTSPTHVHVAQPTTTTTTTSTSQPIDRDVASSAVNHTSNAVNDKKQQVASHLSSQSAEASDRAHHLASQAKDQAHDAAQVVSDKADQVVDKSGRLASDASDKVAQLSKDGQKIVSEKTNEVSRLASDTADLVSHKATRTAQNTSEALETASDEVAQATGQAKRIASEKADDAAEAAKVAADKAGQEANKTGQVVADTASKVVSFIKSTLLLLGTGAFLVYAYDSRAGVYRWVVLPAVMALTKNDPEQAHEWAVQFLSSGLAPVDCGKDDPALLSTEVWGQTFSSPIGMAAGWDKHAVAIDGLFNLGFSYVEVGSVTPESQPGNPKPRLFRVPEMDAVVNRYGFNSEGHQIVQSRLRQRLEKWVHLMKAHLPADFLPTPPAATDSIQIGAERDVVEGLLTSEGGKEALVADRLGLPRSLKPGRVLGINLGKNKTSDPDSIEDFVKGVTSLGPYADVLVINVSSPNTPGLRDLQRKGMMTELLNGVVQARNDLKGEKKPPILVKIAPDVDAKQLEDIAEAVKISKVDGIIVSNTTISRPDLSNSSASTETISVLAETGGLSGPPVKPLALKAISTLYELTDGQIPLVGCGGISSGQDAVDFAKAGASLVQVYTGFIYHGVGLPRKIKDELMVILQEEGKSWSQLVGSGRRAKKEVEEKKVVEKFVPEKSEEGTKPVGEKDFEDSLKEAKADLDALLKDLASFGSTPASANAENKTSPTMGKADAIPPIEVVGSEKAEAKRDPSGVRGSAVPAPVAESFASNAESNLTPKASTKPSESTSTSTSSEERAPQSVMAQIFANKSPTIDDSKLSAPAQALLDDEAIKVLLDPIGATQQKKGDSKETVKAKEEKKVDDRPVRVEGKRWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LUV5</accession>
    <name>A0A2X0LUV5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C017g08497 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C017g08497</name>
        <name evidence="7" type="ORF">BQ5605_C017G08497</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY20155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LUV5"/>
    <dbReference type="STRING" id="796604.A0A2X0LUV5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="54"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY20155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="497" mass="53718" checksum="765A2F4D405E8587" modified="2018-09-12" version="1">MATAIPISATPVEGHNDGDDFLAYLASNPKTNLVSSSQDKEQFDSLTGAFNQRLYTSATAIVTPTNAQAISSAVTFARQYNIPVTARGGGHSYAAYGVGNGNAQGLVIDLSHFSNIELKDDNRTVVVGGGVRLGDMALQLDEWGLAIAHGVCPFVGVGGHAAFGGFGYASRAWGLTLDHIIALDVVMADGTYLQGLTREQDPDLFWALCGAAPNFGIQTAYHFRAHEKPNNVVRVKYSYSNASPDMMTRAFLAFQAWGQESSPPNLGLTAVIGGGGSFEITGIYYGTGDACKKLMAPFEDKLPEGFSTEVDQAMSWIESLQALSHSQPLSTKGKTGFRDCFYAKSLMTPDSPNQLITTDAALAFFTYLQKTATTTNWFVEIDLYGGAGSAINAVPLNQSSFAHRSSLLSFQMYASSKTYGNPYPEDGFDFVSGMYDALLNPMKEIWGTSYGAYVNYGKSETLYWGSQYERLSTLRAKYDPTEVFKYPQAIRPSTSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LVB7</accession>
    <name>A0A2X0LVB7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">BQ5605_C010g06197 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">BQ5605_C010g06197</name>
        <name evidence="15" type="ORF">BQ5605_C010G06197</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NDC80/HEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LVB7"/>
    <dbReference type="STRING" id="796604.A0A2X0LVB7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.30">
        <property type="entry name" value="Ncd80 complex, Ncd80 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005550">
        <property type="entry name" value="Kinetochore_Ndc80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055260">
        <property type="entry name" value="Ndc80_CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038273">
        <property type="entry name" value="Ndc80_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03801">
        <property type="entry name" value="Ndc80_HEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="11" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Ndc80 CH" evidence="14">
        <location>
            <begin position="217"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="190"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="432"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="246"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SGY14482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="811" mass="89872" checksum="1BE0AE2E83775009" modified="2018-09-12" version="1">MDARRRTLATSGTNPTYPGQPPQQQGQSMIPTSTRKPTHANLRQSMLPSATTSTAAGTTTTVGGPRASIAPSRSNSNLAMTARQSMLPGNSSANANNNNNDVGAVSSQTSSWGGASQVFSQGHGGPSAPTVPMTATRPGAYHVNPSLGSMSVGRPTGGGMRGSSILANQHPALMAPNRYVNTRLRPFLLHPTLTGTDDTSNPRRPDHSARRSSSFRRSTIGNNPGGNPTSLSTPGGLKSAMTTMKPKIDPREAKKKSSETRKQWALEIVDFLLECQFAADEKMLLAPTGAQWQAIFKTLVFEFDPTITWEGKSFNDQVPIVLNEIGYPFPASITKSHLQSAGSSQSWPGMLAMMHWIVTTIKESETAFNESTEIKMPDFDAVLARGTTDEDHLVQHAWFDYVASAYPKFLVSDEFEADEEKDLFWKRMDPVRRVQRDRLDQLTIEYEELEREWKELQLHPDPLIELSAQVEGFKRDELTCRKWTDELTEKLTRYTSEHERVSQVIQQTVNANSNSLNEIGSLEDQVKNQDMSQAEIAETNSECKRLDSTTRETRNKIVTTLKRVLEQEIEVERHLALAKRLAEEYSNIVGPLGLLRNDLTTNVALAGLLNGHEHVDFNQEISPASDNPAPDCTTYIKPALSEMKVKTKAELRKLQADEVTKEAEVKIKQVEESDQEEISKHLVDEEKRLMREMQALEESAANEFGTLNASIAALQSAVDELSSTMAQPFAQAEYRLEQRTLELSRVTKEASSRLQENSTKFEQALSRALGHKEHTVACISKGLEMVEEAKRTWIAPPVIKLEMRGASALEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LVI6</accession>
    <name>A0A2X0LVI6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="19">BQ5605_C016g08108 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">BQ5605_C016g08108</name>
        <name evidence="19" type="ORF">BQ5605_C016G08108</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>siroheme</name>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism; nitrate reduction (assimilation).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY20621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LVI6"/>
    <dbReference type="STRING" id="796604.A0A2X0LVI6"/>
    <dbReference type="UniPathway" id="UPA00653"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008942">
        <property type="term" value="F:nitrite reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03529">
        <property type="entry name" value="Rieske_NirD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="entry name" value="BFD-like [2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="entry name" value="Sulfite Reductase Hemoprotein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052034">
        <property type="entry name" value="NasD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012748">
        <property type="entry name" value="Rieske-like_NirD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02378">
        <property type="entry name" value="nirD_assim_sml"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43809">
        <property type="entry name" value="NITRITE REDUCTASE (NADH) LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43809:SF1">
        <property type="entry name" value="NITRITE REDUCTASE (NADH) LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13806">
        <property type="entry name" value="Rieske_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="Nitrite and sulphite reductase 4Fe-4S domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="Nitrite/Sulfite reductase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="18">
        <location>
            <begin position="957"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="920"/>
            <end position="939"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="SGY20621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1130" mass="124375" checksum="3E5A431DE42C9229" modified="2018-09-12" version="1">MVPIANSTIHVPKTNRIQIFVVGLGMVGIAFIEKVLNLDQDKRYFIRTCGEEKHLAYNRVGLTEYFQHRNVEDLYLNDPNWYAEQEPDRFAFHVGEQVTLIDSKSKTVSTSRGNTFSYDILVLATGSGAGLPPYVSIEQAEKTTGVFVYRNIADLESIMDYAELSHISRASVVGGGLLGLEAAKAVYDMPGVPDVSILIRQNYPLNRQLDPSAGELVLRKIENMGVKVLTQCEPQAITTRTDENGQEVFTGFTTSDGEHIESDLTIFAIGIKPRDDLAAASGIRCARRGGIDVGDDLMTSEQDIYAIGECASWRGNTYGLIAPGVEMADILAFNLTQTAGHAPRKMNDPDLSTKLKLMGVDVASFGDYFADERMVKDIEAAEKKKVEVGVEIASSKPSRRKKGPRDTKNDPIKCLTYHDPFSSTYKKYIFTADGTHLLGGIMIGDVASFTKMVSIVKKKKKLDCPPSEFIMGAKKEGEDDGADLDDDAQICSCHNVLKGAIGACIKDGCTDFATLKSKTKVGAGCGGCVPLATSIFKAEMKKAGHAANNDLCTHFKMGRTDLFQVVKIKQLRDFATIIATVGAGKDRQGCEICKPAVASILSSLYNEHVMLPQHHGLQDTNDRFLANIQRNGTFSVVPRMAGGEVTPEKLIALGQVAKEYGLYTKITGGQRIDLFGAQKRDLPDIWEKLIAAGFESGHAYGKSLRTVKSCVGTTWCRYGVGDSVGLAIDLENRYRGVRSPHKFKGGVSGCVRECAEAQSKDFGLIATDKGWNGEFPDPKTCPNDLFELMRPVSPKYAVFIGGNGGANPRHAHLFAKDVPPTKVVRIIDRFLMFYIRTADRLVRTAPWVEKFDGGIEKLKKILLDDELGICGDLDREMDALIGTYKDEWAAAITHPELRKSFKQFANTDERRVGIEPITERGQNRPADWPKNFPAKRFEDNEVPTPRSEWEWVNLATTQDLMPTEANTTSAAVRYGQDTQLAIFHVPKRGYFATQQMCPHKRAFVLEHGIIGDDANGNLYVSCPLHKRNFRLDTGECTNDEEYKVLAFEVKNEGEDLFVKLPPAEELDALIGSTKWMVRKATAEALGRNSATAIEIVGPSGELDEERLAASNDCAIKHENGSGCGSNKLEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LVR3</accession>
    <name>A0A2X0LVR3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C016g08208 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C016g08208</name>
        <name evidence="3" type="ORF">BQ5605_C016G08208</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY21195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0LVR3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF159">
        <property type="entry name" value="LD03170P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="725"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1008"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="278"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="437"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="565"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1009"/>
            <end position="1022"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY21195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1322" mass="143037" checksum="F29C61570136619F" modified="2018-09-12" version="1">MADTSPSCWGASLSQSEVEVTTRAQVSRGSGPAEPSRLRFCVPTTCLNPQAISTSQAIRSASPVEDPSRTPRQRSRTEFDNRPYAAAENWTLSHDCVAPKLVPRLDSIMTSTRSSSLATAVSHVSDQQYHESSAGHGAGDSAEGSYALLVTGMLGLAVVGSTVVEAQGHDVQTTIPIGLPPHGRSPILMDEPVDHAGFGSGDSGFLSTENADESMRRGRGRTSRSTSIIGRFSRSASPDWSSPSSLREVPSSTNVSSWTPDRSPSSTLLHNVPLFGKSPARSTHTTSSRRPSTSDAITSRWRQQNLLAHVENSSEKLSTSLLPSPKETKDDQATVTSVKQLVLQTRRSSIPAVREFTVADEKRSSVRSIDRARDGLGLNLELFDIAQDSPAHLSTASPVPTVNVARPRTPSVDQSDQFDPECSFSILADGLDPSPRSAASTSSNTESVSPSFLVTDDSPVLSTSTYSSARPVRYNTSPSAESPQFFLARTTESPMLPPSSSNQRTSSAPQVDTWAGGVPMPTPRENHALPTPDTSLSVPEALAPLEKRATTSPPLAVRTTPGVDQTSQRGTGRSRQTSSGSDTPGSKISRRLSSFFSKLTPSTSPASLSRPTTPTLNRSPIEDGGSKRNRAGSHSKSPSPATLGPPASIHQNSQSSTPSSTLKKGTIRGSISMPSPAITDPASAASSESNKVLNSSPLPSRTLRSIMGAQDYNDAIARHGMLEMKRQEVIFELCETERSFVEALKGVMEVFALPLRDRQGGWIRGVPIVVARLFDWAADIVYVSRLHAQIAEALLYARGRKPQDIVTRIATVFMPFVPQLEIHQPYLVRFESVTRLIERMAADQNSDFGAFVRMQTRSFLGGMTLSSFLLKPVQRLMKYPLFFKQLCELTPKDHVNYRATISLLRDTDLIIRVMQEVKSREDEYEELKRIEAKMRGLPQGFRLAQRDRRLLAQGSMKRIHASEKGRSALLVAEASGVRRRSSIPAIPEKPLVASSLPVKLPLLVESRRSLSGTSDSGSDDPSILTEHDQTSWPAQCATLDTKASYPKASSLLPKTLPGLPNEGPGVFSSSPVSMGLGEGVTGGDSPNVFALSLPKRPGSSMSLDSISGRRTKPLKLRAKESYVQVFIFSDLVVFAQRMTENGSKMSSKGASLGPDRPGTAYEIIESIGVSKVDRVMDLSGQTEHDHLLAVALTPLASEPVTVFLTVPPQTTSGSSGSSNLPSSTKIHARWNNAFERSRIKSAKLSNILPGPLRTLDIPVTTDERTLAASFLKSPGEGYTAPIEPLDERVDLTSERAECDWWRLRFNKMRSELETESSHHLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LWP3</accession>
    <name>A0A2X0LWP3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein kinase</fullName>
            <ecNumber evidence="8">2.7.11.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C012g06832</name>
        <name evidence="12" type="ORF">BQ5605_C012G06832</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.21" evidence="8"/>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LWP3"/>
    <dbReference type="STRING" id="796604.A0A2X0LWP3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13118">
        <property type="entry name" value="POLO_box_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13117">
        <property type="entry name" value="POLO_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14099">
        <property type="entry name" value="STKc_PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.30">
        <property type="entry name" value="POLO box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033701">
        <property type="entry name" value="POLO_box_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033695">
        <property type="entry name" value="POLO_box_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000959">
        <property type="entry name" value="POLO_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036947">
        <property type="entry name" value="POLO_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF0">
        <property type="entry name" value="CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00659">
        <property type="entry name" value="POLO_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82615">
        <property type="entry name" value="Polo-box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50078">
        <property type="entry name" value="POLO_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="123"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="POLO box" evidence="11">
        <location>
            <begin position="672"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="552"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="554"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="594"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY16290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="903" mass="99347" checksum="9B38FCB904FF1D89" modified="2018-09-12" version="1">MLVHPPQPRHPFAGASSSAAPPSRHVPTLTSSSSVGAAVAASGRARPPLSASAQMRASISKGLQTTRSGAAELPATTVSTTAPTTTTTTQKATTRTRAPSDRAKLTEQWGPPPAVIRRDGEHLHRGELLGEGGFARVYLITEPDGITNKAVKVICKEQLRSTKNRSKLFGEIKIHQAMKHTNILSFEHCFEDEANVYMQLELCSNGSLLDLLRKRRRYTEPETRFYLVQLIGACHYMHSNSVIHRDLKLGNLMLDAEMNLRVGDFGLAALVKFPGERKKTICGTPNYIAPEILFDTTNGHSFEVDIWSLGVIMYTLLVGKPPFQTKEVKNIYLRIKELNYEFPAGCELSAEAVDLISLILTPKPNERPTLGQILQHDFFVTGPFPASVTPASLTLVPDHRNMSIRSAHRNFRAVKARAGLTEQVEAEMLEANAAEIAAVEKPSLRTVLATVHESAAPAPAAQAAAPVARKRMSATVTADARAIEQEVQQVLAPESPISDLLRSARKPLMVSPDAEPCELLQRRLAAEARPTSSNPTSTNGATTLSARLAANAPTKENLSPSQPSAGDKENSLAKGGKPVGGATTVSKHRRSALSTTSTVPVPSSPNRTSSAAVPISLVAPKPVVKTVDTARHPARELYDTTWRTLHSALTIETLADLEALPRPDDSMAPKVFITSWVDYTHKYGTAYSLTDGTAGLYFNDSTTMVLSPDKNHFDYIAQRKGNIYTRRHYALTDHPEDLQRKAYLLEYFEDYMAKTLTRDVAWTFVDAARTKNMCFLVKYYRMKHAIVFKLSNEVLQFNFYDHTKLLITQHGSVVSFIDGDFRLHTYSLGALFDEASKLGHYRPSTSTTPGSAMTTEEARRLKKLDKVRFIIDKLEYCRDVIRTLSLRKKTTTTTTTTTTTTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LWS4</accession>
    <name>A0A2X0LWS4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C018g08710 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C018g08710</name>
        <name evidence="2" type="ORF">BQ5605_C018G08710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY26216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LWS4"/>
    <dbReference type="STRING" id="796604.A0A2X0LWS4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010237">
        <property type="entry name" value="Pyr-5-nucltdase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052791">
        <property type="entry name" value="SSM1_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01993">
        <property type="entry name" value="Pyr-5-nucltdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438:SF1">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01132">
        <property type="entry name" value="C1.5.3:_5'-Nucleotidase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY26216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="288" mass="32238" checksum="A28FBE425D59EB3F" modified="2018-09-12" version="1">MALLLVTDPDGSPRPRLHPSPVGDSPNNLSNPSDPSDPSNRDPRPIIWFDIDNYSKDAGVDDLMKEKIENYFEKIGIPSDESRILRHRYYTEYGLAIRGLVRHHKVDPLDYDAQCDAALPLENVLKPDPERQHLLRDIDRSRFRVWALTNAYVNHATRVLRLLGLAEYFEGVVSCDYTATAGTFSCKPEPAYYREALAAANATPDQCYFVDDSALNIKGAHALGWGKCVLFDEHGDQRPKLDGIDEQATSTTPTGTGSDFQQSGEVRVVGRFTDLRQVWKEVFVQGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LWY1</accession>
    <name>A0A2X0LWY1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C018g08763</name>
        <name evidence="9" type="ORF">BQ5605_C018G08763</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN4 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY26725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LWY1"/>
    <dbReference type="STRING" id="796604.A0A2X0LWY1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF2">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="213"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY26725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="461" mass="50871" checksum="8F500C63C4EF6C21" modified="2018-09-12" version="1">MRSKIGNFGGFYLRASSWAFGGPASLGLATAWLACKSLQFPAPCMQLLNEVVSASSSLPLDLIRFLDATLASDFPPIVARPTLSAYIETLCNIVNRDVKKHAMGESLQKLQSRTTTYEEQITTLREHYATLLEEDEEWISAAQVLVGVVTDASDRPVEYKLKIYIRIVRLYLEEEDSTSAETYFNRASLISHSTDDLETQLQFKLCQARMLDFNRKFVEAASRYHEISYIAALEEADRLRCLAAAITCAILAPAGPRRSRILSALFRDERSSETPHQTVLAKMFLDQTFQPTEIAEFAASLSPHQLARLPPAAVTVIEDDTTMEMGKRGPETLLDRAVMEHNILATSKVYNNITFTGLGHLLGIRPSSGESMVRTMIQQGRLCASINQVLGLVNFIGDGKAGDGVMSNVAAAATASPAPEESELLLDDMATKRWNLQIRSTLQLAEAIALRCEEMITGLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZ93</accession>
    <name>A0A2X0LZ93_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C017g08414 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C017g08414</name>
        <name evidence="3" type="ORF">BQ5605_C017G08414</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY19973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LZ93"/>
    <dbReference type="STRING" id="796604.A0A2X0LZ93"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1390.30:FF:000001">
        <property type="entry name" value="GTP cyclohydrolase 1 type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.30">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="NGG1 INTERACTING FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799:SF13">
        <property type="entry name" value="NIF3-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="DUF34_NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602678-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY19973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="300" mass="32170" checksum="1CF57D2073FF878B" modified="2018-09-12" version="1">MHRGLRNIYRTMSSISAASFSSFSSSSFSTVRSPVLNHLLAAVERLTPLQLAGSWDNVGVMIEAPYPRQEIKGKKQVLTCIDPVTEEALASSSTAAVLTYHPPIFSGLKSMTLAVPLQASLLRLSTHGIPVVCIHTASDSSIGGVNDHIASAFTSDLRATSKAIEESKEQPEGHEGCGLGRLVTLDHALNKHEVVKRIKHTLNLDHAQAAWAPNGAEKIKTIAICAGSADLYLSGEFDHHATLLCNAKGIHVILTNHSASERPWLKPFAPRLAKAMNEEAGGDAYEVLISMADIEPLSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZ99</accession>
    <name>A0A2X0LZ99_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C002g01613</name>
        <name evidence="5" type="ORF">BQ5605_C002G01613</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY34330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LZ99"/>
    <dbReference type="STRING" id="796604.A0A2X0LZ99"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000554">
        <property type="entry name" value="Ribosomal_eS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047861">
        <property type="entry name" value="Ribosomal_eS7_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01251">
        <property type="entry name" value="Ribosomal_S7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00948">
        <property type="entry name" value="RIBOSOMAL_S7E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY34330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="196" mass="22178" checksum="8181A5D4CDDA760A" modified="2018-09-12" version="1">MSASKILRSANAPRTAPDALETSVAQALLDLENGVAELKAELRPLQISAAREVDIKGGRKAIVIFVPMTQLKAFHKIQGRLTRELEKKFSERHVVFIGQRRMMRKPTRGSRQKQMRPRSRTLKEVHSAILDDLVYPTEVTGKRTRQNVDGSKLIKVFLDQRDATSLEYKLETFSSVYRKLTGKEVHFSFVAGQDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZS0</accession>
    <name>A0A2X0LZS0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C016g08052 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C016g08052</name>
        <name evidence="3" type="ORF">BQ5605_C016G08052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY20444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LZS0"/>
    <dbReference type="STRING" id="796604.A0A2X0LZS0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY20444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="375" mass="39711" checksum="80AC4F91753CCD07" modified="2018-09-12" version="1">MLAAIDACPTHRHSGSAMLAAIGRWALLLLGLATIVSVTVVDAAAISNATTNGTATANTTNTNAANTMTTYQDDLGFYNVTPGGGRWLTARGRVRPSLRKPSPSFYAHGPGAGGRSDSKDKPMRGQQRFEYETKADSLSIQSQYAVDGTLLGEPINVVVSADSDPLIMTEAGLNDWLLSIQYGAEFLNVSLGTKQKADLGDGNGRRNQSEILRYNYFDTIYGTLHESVNGGSHVRIWNQNGPTADSGAWFIAASVEYPAAMGHLIKPNGYDLGRDEVVGNATMKNGTISPATNRTFSATSQLIQFLPANSSANINHDIETDGNVAILTVKVTNNGSANASAKSGSMASMLTFMPLQAKILVMASTVLSIAFTLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M003</accession>
    <name>A0A2X0M003_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C003g01878 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C003g01878</name>
        <name evidence="5" type="ORF">BQ5605_C003G01878</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNAP-25 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY37740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M003"/>
    <dbReference type="STRING" id="796604.A0A2X0M003"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15857">
        <property type="entry name" value="SNARE_SEC9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15886">
        <property type="entry name" value="SNARE_SEC9N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305">
        <property type="entry name" value="SYNAPTOSOMAL ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305:SF9">
        <property type="entry name" value="SYNAPTOSOMAL-ASSOCIATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="4">
        <location>
            <begin position="349"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="233"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY37740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="412" mass="44594" checksum="623EAE026D34B27F" modified="2018-09-12" version="1">MGLFAKKKKELIPEVDPSGFNGANASYSNAPSRGGGGGPSSSYQGSIAPSEYSTAAPSYRTQGAGSYLPPSQGGAGYGAYQSHYSRPQPGSGAPPPQGGAAYGPGAGGAGLSQAGAPAQGVSSFRDRFAKKNPGRGEANPEARNELLAGAPHPQQQQQPNSSRPYGGGAYGVDGREDDQPLDEDEEVEGIKQQMRFVKQESLASSRNAVRIAREAEETARATLDKLGDQSDRIANTERHLDLAKAHNDRAQDETKELMALNRSIFRPNITFNKQAKRDRDEARIIARHNAEKDERELVRREQYESHQRIDQTYHSMDRKADDAARARQRAKARGAERGRYQFEATASDDEVEDEIDGNLDELSGLAGRLKMLATTAGQEVDAQNTKLSKLGNKVDVLDTNVVRSTQRLARVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M098</accession>
    <name>A0A2X0M098_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C019g08995 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C019g08995</name>
        <name evidence="9" type="ORF">BQ5605_C019G08995</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY23920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M098"/>
    <dbReference type="STRING" id="796604.A0A2X0M098"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000068">
        <property type="entry name" value="Chaperone protein dnaJ 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000003">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="9"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="8">
        <location>
            <begin position="152"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="5">
        <location>
            <begin position="152"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="395"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY23920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="427" mass="46032" checksum="6A9105BD290DE9F1" modified="2018-09-12" version="1">MNRGGKHTGLYETLGVDPSASEADLKKAYRKKALQLHPDKNPAGADEFKACSHGQSRLTQRRIGRRVAYEVLSDPDKRRIYDQYGEEGLSGGGAGGMGGMDPQDLFSQLFGGGGGFFGGGGGGGRGGRPSGPKKGKDLVHRIKVSLEDLYKGKTTKLALQKHVLCTKCKGKGGKEGAVKTCQGCQGQGVKVVLRQLGPMVQQIQQTCSECNGEGEIVNAKDRCKTCNGKKIVNERKVLEVFIDKGMKEGQTITFNGEADQAPNMEPGDVVIVVEEKPHDTFKRRGDDLYAEVEIDLLTALGGGAFAIPHLDDRALLVKIPPGDVIKPGAVKVIPNQGMPSYRHHEMGDLIVQINVKFPDSLDPSTLAPLEKILPARPELPTFPDSIMIDDNVEMVDAGDRKSKTMREDQMDEDEDGSAGPQVQCANQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M0W2</accession>
    <name>A0A2X0M0W2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C019g08964 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C019g08964</name>
        <name evidence="3" type="ORF">BQ5605_C019G08964</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY23654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M0W2"/>
    <dbReference type="STRING" id="796604.A0A2X0M0W2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY23654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="265" mass="29472" checksum="168DC9980C6BBABB" modified="2018-09-12" version="1">MGIGANRSNSKSPSVRPQALPTGNSSNAPFTNSANPAGGATRGQQQNDRLYLCLPFVKAALVKGNFKTIVALPKYVDVNEWVAVNLVDLFNNLNLFYSVVTEFCTIENNPTMSAGPGMDYTWIDANRKRVKLPAPQYIDYVLTWVEGLIKDESVFPTKAGREFSPNFPSVARHIYTQLLRIFAHLYHAHYPIFLHLSSEGHLNSLFAHFLTFGREFDLLEEKETRAPKEGWPFVIGDLMDVSRPLQSQTLATGGAAWKGLGILEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M1M8</accession>
    <name>A0A2X0M1M8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C002g01092 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C002g01092</name>
        <name evidence="3" type="ORF">BQ5605_C002G01092</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY29885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M1M8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="595"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY29885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="820" mass="90165" checksum="F209FBC71CF8A746" modified="2018-09-12" version="1">MASNSPPTRWQSGEVLAPVRSKSDSVAANLVQACAPSPHSRPRRAPPIHRSTAPPCLGGLDQRTPSNRGMVENGDTSKRWLWSHGSLSSSSSSSPFPASRQGTLAGLGGGDTGASGLSMSHISSAYSRLLPAKGSLQPAQNGLRPLMYRLGSRRYRSSRTMALWTALIFILLIVLYAPPLDDGLEHFISNQSDVSFMPSKLQQSLGVLRNGVKSGVRQAVNQLPKLPWVSAVTDRASRNKSIKISMLPIKPDYPTHNHPEERYIGFLPHSGFDQQRSAFATALMLGKKLNRTVLVPPVWLGKPNPYKPYDQLQGSWNDALHQYPSSFRISGDKGRFPSSTKSPLLKPGNYSSTLNGALDIGKLTLGPDTMENAADCKPSDAECQKPSTTFVSWDRLVDLDAVTRNNGVKLVNRWDMREKALEQLLEKRPEDFFILHDQSHDDLSFLDDISGKVGVGAFTNQSTPPLLHSASGSRSDRSGSREVSLSALNMLSQKVLLVGSLAGTMRLQSLDPALSSLHQSLAFRSSRLIAPARAMRHRLGGAHGYAGVYARIRNKTNKDPAELYLGEAWHDLVARLKIEPSVAQAMWELVRPVNEKRSVSKSTPTRSSSRKKSRLKKIRLSADVLSGAPKRPLGLKTGSTIFEDDTTVFSLPATTSHHRLHRRHIRGEQSPSPDLVFNQCRSNVHTDSEYLPFNTPIYLATNSPDPEGDPKLAIFFKAFPCTFIRSDFEVPSKMNGGEVVESLLKLRRLVNVNDGAALGQMFEPLLDQTVVAMAMISVQAKGTLSSTFVERDLHTAYRQDRYDEQQVPAESNHGTVFGHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M2P0</accession>
    <name>A0A2X0M2P0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C001g00233 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C001g00233</name>
        <name evidence="1" type="ORF">BQ5605_C001G00233</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY45011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M2P0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY45011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="43" mass="4905" checksum="DD1E2D3633406938" modified="2018-09-12" version="1">MGLFLVRRPQFSSDSLEPITEMALRVEELRASIQESKARLVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M3T7</accession>
    <name>A0A2X0M3T7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C002g01781 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C002g01781</name>
        <name evidence="5" type="ORF">BQ5605_C002G01781</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY35579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M3T7"/>
    <dbReference type="STRING" id="796604.A0A2X0M3T7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_uS2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_uS2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S2 PROKARYOTIC AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY35579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="377" mass="40817" checksum="632CBDDBC9DF5CA4" modified="2018-09-12" version="1">MSLSKCIRSLPASTSSSLNLTRAVSTSTSSPSSSSSSSSTDASTPSSPAQPVLTSRQKQAQQSWSEMMTKVSERRARRYTGQYESPSPFPFALLSFIPDLPLLPTADAQMTHLGSTQDATSQYRPHHNLSRSPTSLSATISHLIASGAHLGHSTSLTHRAAIPSIYGTRTGISYIDLRQTLPALRRAAQVVRGVVERDGIVVFVGSLKGTEKTLWTNAQRLGSNGYAVTKWLPGTISNAREVFKHSEIPFTVSPTSSYGAGRDKREKAPTKPTPTSFKPDLMILLSPTLNEHALREATSNEIPTIGIMDTDLDPRLVTYSIPANDDSPRTIELIAGVLGMAGKDGLQRKVKRQAIEAMRLASRKQGMMEARKLGSHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M3X9</accession>
    <name>A0A2X0M3X9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C002g01821 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C002g01821</name>
        <name evidence="10" type="ORF">BQ5605_C002G01821</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY35954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M3X9"/>
    <dbReference type="STRING" id="796604.A0A2X0M3X9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF3">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="88"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="278"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY35954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="531" mass="56738" checksum="1D89F11E8BE625BE" modified="2018-09-12" version="1">MPTGRFSKMRHAVMSSPSCALSRVPTTSLYFVSETANDVELVEVMTDRARPAPETRASTISTKGSEHREHPSTGLGAARASRIWHMARRCVAFAMVFMVGIHISATGLNISLMQTHYNLSYTQISTVFPPMIAAHAIACGSCSYLLHGIGMRWALTLACVVWSIGCAMLIAEPPLAWCVVGLGSLGVGAGTYNSVLTAFTSHEEDAVLMGWLYASFAFGGAIAPLIVGVFVAHGIGWNKFYILLLAFSNLLGGISLVLVGEWEVSLDQKAGSAPSTTRRPEAENESEHLRPAPSATARLCEALHLKIVWMGLLLIGITYGSADALASWTSSYFLDVKHAPKSASKYLMSGLWGGMAVGRLTLPWLFRGRVGERTAAIGTLTVAIVMLTVMWLVESFKVAAVALAFAGFSAGPMTPHVLSTVTSRVPAALKASVVSLILGTAVLSGGGGPLLFGLIVERGWISSLPPCLIVASALAVCFWALLPPRCAATLQLSRFWFLPFPSFSCRSFEFQFRVGIFNSDVGGFDSDKHIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M4A2</accession>
    <name>A0A2X0M4A2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g02114 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C003g02114</name>
        <name evidence="1" type="ORF">BQ5605_C003G02114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY38973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M4A2"/>
    <dbReference type="STRING" id="796604.A0A2X0M4A2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY38973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="358" mass="40003" checksum="82CF6FE672328E63" modified="2018-09-12" version="1">MGIDNGAPFLRQSIAKEPRSLMGTATDPARLLPAIDGDKPKTFSSLALHCGPDFSASCTLTYRKALLPRSHLFCDRLLSPRLLVLLIEASTAFRDIWISTVGRKHRGRSFIDIVIARLKVLKEEQSSLQVVVILDNAKWRPKLKEATAKERAERSTIAPDNVDVRFSDFRTKPICLSSEEVQVLQERLPQPSAPNVNLDQIHVWRVGSGITFVMARTEADTYMCASARRGHNIDVRLDSQSTVLWSGDTDWIYGLPARFCRWRIYEERTLLKPAEELKDVSLDTLVVDESFVAQAGGTRTKRKIFLLVDLLELKQWGTDEALVVAGIVAGGDYLSGGLPGIGLHRTFEKYKSTAHAKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M594</accession>
    <name>A0A2X0M594_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g03866 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g03866</name>
        <name evidence="1" type="ORF">BQ5605_C006G03866</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY54334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M594"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY54334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="61" mass="6341" checksum="07D88091BB559F3D" modified="2018-09-12" version="1">MPPIAEFPGESQSPGVATYTSCFWVGGAVMLPFSGGEAVAKDSLEAGLALRDRAQLVPNDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-11-27" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M5E2</accession>
    <name>A0A2X0M5E2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C-8 sterol isomerase</fullName>
            <ecNumber evidence="8">5.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Delta-8--delta-7 sterol isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C003g02333</name>
        <name evidence="10" type="ORF">BQ5605_C003G02333</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ERG2 family.</text>
    </comment>
    <dbReference type="EC" id="5.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY40174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M5E2"/>
    <dbReference type="STRING" id="796604.A0A2X0M5E2"/>
    <dbReference type="UniPathway" id="UPA00768"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006716">
        <property type="entry name" value="ERG2_sigma1_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868">
        <property type="entry name" value="SIGMA 1-TYPE OPIOID RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868:SF1">
        <property type="entry name" value="SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04622">
        <property type="entry name" value="ERG2_Sigma1R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015892995" description="C-8 sterol isomerase" evidence="9">
        <location>
            <begin position="25"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY40174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="293" mass="32538" checksum="E098A4C7658402C5" modified="2018-09-12" version="1">MPRAAARPPHLLLLVVAVTTALMSQSTLKGKRNNGSPIVGTIRVTPRRKSLFSMKGAVAFGVVAALMSLAVVWLESIKHTWYIFDSPTLHALCREAIALYPDDMPSIAHHIVTNLTLTHNSYSINSEPFFASPLELDNETRAVKASSYRPNPREWVFNNAAGAMGTMYIIHASITEYLIIFGTPLGTEGHTGRHTADDYFHILKGEQWASEAGSFDIERYPVGTMHHLRRGDVKQYKFHEGGFALELAQGWIPLMLPMGLADTLSSTLDLPTFYHTVRITAREMLTNLLHGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M6F7</accession>
    <name>A0A2X0M6F7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g04256 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g04256</name>
        <name evidence="2" type="ORF">BQ5605_C006G04256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY57329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M6F7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY57329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="91" mass="9821" checksum="58E3306210DDCEF0" modified="2018-09-12" version="1">MYTSERNPDAQCTSPLISRSPRPNPAPSIATIGSMPDAPPMRLPRVVRFDPTPPLPVSEALEVVACLPRYQTRTLAVRSIAAISKSAPSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M6K4</accession>
    <name>A0A2X0M6K4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00067 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00067</name>
        <name evidence="2" type="ORF">BQ5605_C001G00067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY43831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M6K4"/>
    <dbReference type="STRING" id="796604.A0A2X0M6K4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY43831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="366" mass="40420" checksum="DED303670B400A3A" modified="2018-09-12" version="1">MATSPDKFKKLAPVRAERGGIEGGPQRTIHAARWDDLSGTSTLTQGLRALQTLLAFILLCIYLSLAGFQRDHSVGPSFLVIFALMIIVSATLHSMVLLGVALYSDNVRLFRSMARGMRKIRVAMIVNTNQVIWIFMAMVSVTVSTRAGGCKSPALDEHAGNKAYTALLPPYCRDKRAGAVFFWLLFITWCASLGITIASWYRARRRPQSQAFPSVPGVHEPPIDLEREPPFESPYDVAMMERQAVIQSDGTPSTACVYEPNHDYQVLNGVYESPQVVVSSDAGHSSMTAITNTGMSRFENSMTNVMSPGTTLVSGRLSSQVYGGEKDPFVDQAREERSHLTYQDPYEMARASIDMTEGLHQHTTPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M6Q5</accession>
    <name>A0A2X0M6Q5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BQ5605_C001g00238 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C001g00238</name>
        <name evidence="8" type="synonym">SEY1</name>
        <name evidence="12" type="ORF">BQ5605_C001G00238</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="8">Enriched in the cortical ER. Concentrated in punctae along the ER tubules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY45039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M6Q5"/>
    <dbReference type="STRING" id="796604.A0A2X0M6Q5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016320">
        <property type="term" value="P:endoplasmic reticulum membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01851">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000727">
        <property type="entry name" value="Protein SEY1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03109">
        <property type="entry name" value="Sey1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030386">
        <property type="entry name" value="G_GB1_RHD3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008803">
        <property type="entry name" value="RHD3/Sey1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046758">
        <property type="entry name" value="Sey1/RHD3-like_3HB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45923">
        <property type="entry name" value="PROTEIN SEY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45923:SF2">
        <property type="entry name" value="PROTEIN SEY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05879">
        <property type="entry name" value="RHD3_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20428">
        <property type="entry name" value="Sey1_3HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51715">
        <property type="entry name" value="G_GB1_RHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="topological domain" description="Cytoplasmic" evidence="8">
        <location>
            <begin position="1"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="723"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="8">
        <location>
            <begin position="742"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="748"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="8">
        <location>
            <begin position="766"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="domain" description="GB1/RHD3-type G" evidence="11">
        <location>
            <begin position="86"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="827"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="96"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY45039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="850" mass="95034" checksum="F5C5E0EF5A2F9311" modified="2018-09-12" version="1">MNPDQEPLKSALAASSNEVRKEVLSTDTGATTSPSASAPATGVTLSKAKSNGDVAMDAKLQVVDENQNFTDQLNSHMADWELDDKGFAYDVVAVFGSQSTGKSTLLNRLFGTKFDVMNESERRQTTKGIWMSKGRDMPVLVMDVEGTDGRERGEDQDFERKSALFSMAVTEVLIVNIWEHQVGLYQGANMGLLKTVFEVNLGLFLAAKEKGKTAGASQDKTLLLFVIRDHIGATPLENLRNTLTADLNRLWDGLSKPEGLESSQITHFFDLAFVTLPHKLLQPEVFEAEVKNLRKRFVDPSHPDYVFHPKYHKRIPADGVSQYMSTIWDAVVTNKDLDLPTQQELLAQFRCDEIANVAFVVFVDASKAFVSSAPGTLVPGLGKGMQTVRSIALESFDTAASRYHAGVYGRKRAELLDKLNTALLPFVQAHLKNLHKIVLKDFRKKVQERLKVEGYDFAKVVEGTTKEAEKEFEKGSKEVLLEETEWSATETEMQLKEDMVAIADLLRAEETKKMIANIERKFKSQISETVEMSLNKPSPDMWDKVLSAFRKALDKAEETYTRKATSFNCTPEENETALTLLRQRAWLALRAKIDEQTAESVLLVKLKLVFEERFRYDDEGTPRVWRPEDDIDSIFKRAKDEVLGLIPLYTKISPLDEKNAFVLPSDSTPLNNAGDEEFDFESSLTILREAQAEALSSRFRREADAYYLEAKRSMVSSISQIPVWMYAVLAVLGWNEFIAVLRSPVYFTMLLLAASAVYVTIHLGMAGPVFALAKGVSNEVAKTVNDQLHNYFVNQTPEAHAHRQHQQQQRVAVPASKVTAQEDGEVFELKSMESTPSGTVAGGHEKSKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M7S5</accession>
    <name>A0A2X0M7S5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C001g00568 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C001g00568</name>
        <name evidence="10" type="ORF">BQ5605_C001G00568</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY47749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0M7S5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000001">
        <property type="entry name" value="Paired amphipathic helix protein Sin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000002">
        <property type="entry name" value="Paired amphipathic helix protein SIN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000003">
        <property type="entry name" value="Paired amphipathic helix SIN3-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.11">
        <property type="entry name" value="Paired amphipathic helix"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013194">
        <property type="entry name" value="HDAC_interact_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003822">
        <property type="entry name" value="PAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036600">
        <property type="entry name" value="PAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039774">
        <property type="entry name" value="Sin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031693">
        <property type="entry name" value="Sin3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346:SF0">
        <property type="entry name" value="SIN3A, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346">
        <property type="entry name" value="SIN3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02671">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08295">
        <property type="entry name" value="Sin3_corepress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16879">
        <property type="entry name" value="Sin3a_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00761">
        <property type="entry name" value="HDAC_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47762">
        <property type="entry name" value="PAH2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51477">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase interacting" evidence="9">
        <location>
            <begin position="703"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="242"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="451"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="992"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1049"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1423"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1469"/>
            <end position="1493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="290"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="996"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1020"/>
            <end position="1029"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY47749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1493" mass="162855" checksum="8A8A32648E4D08E0" modified="2018-09-12" version="1">MSANASASTSSSNTAPAPAPTPAHPHPSTNPSPAIARPVGARTTALSSANPSRQSSPVAVAPNSTSSEAATPNAAAGPNSTAFRPLNPPELHSVRDALAYLDRVKQQFSAEYTVYDQFLTIMKEFKTQAIDTPGVIDRVSTLFRGHPSLIQGFNTFLPPGYRIECIVSGAGNDAGGASNTITVTTPQGTTTRTQDVAGIEAREFVNAGGAATPQGNGSAAPLTVGKLASAIDATPHVSAAPSAASTSMATSNKPLTSNSTSTLNRGNSNSRIISPPAAIPPFNGGKSTNAQAGSSGSWQAQQQQQPPPTAPRSVRPAQNAPSGRQSKRDDDDPKGKAVDANGDSAMSSAPPPPPSAGPLAQPAPAAQAPTAVPGAGAQPQLEFNHAINYVNKIKNRFTKDPDTYKTFLEILQTYQKEMKPIQEVYTQVTALFHTAPDLLDEFKAFLPDTSEAGNAAVTPGGPAPPPVAQPTSKKSKDGSQQRSADAGSSREDGRSGLGSKKGAFAEEKKKRAAAGSGEKSKVKRTKTHHVDSPPVTAAPPPPKTDRVERSSAMTSQSQAAPPVGEPLQGPPMYHPQPYGAPPANFPGAVRSRSAYEAYLAGHRTPQLVQADEFSFFDRVKKHIDDRTSYTDFLKLLNLFTQEIIDTKTLLEKALIFIGTSDELFAQFKELCGWNPVSDGRIEGEDWIIDNEPAWKRPPVDLRETIEYGPSYRRLPESEIDLACSGRGPLEWSVLNDEWVAWATSQSEGSNAHRKNPYEETMYYAEQERHWYSWHIESNLRTIAHFEPIAARIARMTSEERNAFRLDGLGGTAPSVYERIIRKIWGKEHWHEIVHSLCENPAQTVPLVLARLKQKDEEWKRAEREWNRVWREVDLKNYYRALDHQGILFKALDKKATMTSKALTNEVEALRRDRTQKKTDLDTDVVLRPLHQFVFGMTDRDVLFDVIKLTFSYLDREQSGYSVPERARLEAFVRLFIPLLFDIPQAEMDANLAPQDESQDAPGDDDDIESEADGENDKDASSGSSLNKRNGVNKKGGAADLRKRLLKHVASSSRQKAGSRAGSPNGFDDLLGSLPPGTLGEQKWIQLSSESEADAEAEAPSSPRRYNFFANACFYCLIRMLHVSFPMTVYHRLLAFKQLANELRKKEQAFRLNPLAVDLGLAHPMPIIDEGPNPAEHYYDHLLDLAEKLFEGDIDQQTYEEQLRFMASIKAYPLYTLDKLIGGVIKHVHVANSDAKSQDLTALLEKDRAGSCSTARQMIAYRNEAEAIIGSDDNLYRIEWVSARKKEDCSEMLVAEPHVANAAQIPESQALTIQLLGREDLTLDDSDGPLEYQVHRSWIASYPLTSATEGVGAKVKAPLLKRNRRLSASEDPQEFDLLPGLEAKIVAGNYQLKFIAGTEDYLYRKRPVTRAPTPPPAVAAATLNGTGETNGDAMEGQVAEGSTSETVDEGTLSLQKRRVARFERWLEAKHAKRAPAAESSGDLAVQPEGTAMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M8Q4</accession>
    <name>A0A2X0M8Q4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C006g04025 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C006g04025</name>
        <name evidence="3" type="ORF">BQ5605_C006G04025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY55440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M8Q4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="699"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="730"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY55440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="765" mass="84728" checksum="00B193F45A4FADFE" modified="2018-09-12" version="1">MQRRWGVHINSFSPTGRAASHRLLLALAVENEWETRQFDVLSAYLNGNLGGTEIYMRLPGGDIVRLQRALYGLVQAGREWYKVFTEWILSIGFTRTDSDHAIFVRKEGDRRSFLSIHVDDGLLTGDRDLDGVLCQLKARFEARSTDEASFFLGQSIRREGKTGAAIVNQGPFVDAILKEHHMANASPRPTPLAAPSTLRNRADSGFDPASIPYCAIVGKLLYLSGTTRPDIAFAVSKAARFCNDFTAEHWEALKHILRYLVGTRNFGIRYQKSFQPMSAILEGFVNADHGADPVTRRSVSGYVFMCVGGAISWIAKRQTLVTLSSTEAEYVAMSYATREGIWLCCLLADLGFEQTAPTRLRGDNQSAITLAKHPAFHARTKHIGIHFHFIRDHIAEGMIEMVWVPTGIMAADVLTKGLGTQKHYQISRKAAIGYLIRSARLFSEAWRCAPTVVFSPRLDYTLVSLLFNGTWGDVLIVCMDAGSSGGLSHMWAFSASSSRTDSKGRWKGPRLDANVEYSKYSKRRCMGVFVCCDQSCPGKRRPHTLLSTASRSKLFQEETPQLVTGRLKKAATRKHLAPNVERPSDELPPYPITSCNGPMRHILCSATIARGQQLRQLHKAAPQASAAELRMGQMTTFPQDPCHRPSASEICPVFDSTRSISRYAPRVGHSKRNGALPDTLMSAIEAVANAGCLTYIKIPGQRQGQPPAEQIHDPDPRKQPRNDGSRSKSKITSNSLTDSETTHLTSGVSPMGRELKKLGARDLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M9T8</accession>
    <name>A0A2X0M9T8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C004g03090 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C004g03090</name>
        <name evidence="4" type="ORF">BQ5605_C004G03090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY70013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M9T8"/>
    <dbReference type="STRING" id="796604.A0A2X0M9T8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13437">
        <property type="entry name" value="SPFH_alloslipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000004">
        <property type="entry name" value="Putative membrane protease family, stomatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF19">
        <property type="entry name" value="AT06885P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="3">
        <location>
            <begin position="96"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY70013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="344" mass="36796" checksum="783D9507C520553C" modified="2018-09-12" version="1">MQSSQKTPFSDSSDSHSFNDEANQGTNSGGNPAPAQAQAPPRIITVQPLLRSDMQTSYAQDMGTGSLDHDCYGSVLNFCGVIVGNCGTIPCCPAPNIYKQVGQGSVGLITRFGQFYKSVDPGLVKVNPFTERLRIVDVKIQSIPIPRQNVTTRDNVSVDLDSVMFYHIVSPFRAVFGIADVRNALMERAQTTLRHVIGSRTLQSLLTDREAVASEIESIVEGVAEAWGVKVESILIKDILFSSELQASLSSAAQAKRVGEAKIIAARAEVDSAKLMREAADILSSPAAIQIRQLEALQQMARSSQAKTIFVPMNLFGNGAADTASVAGPSGLNNTAMLNHLADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MA56</accession>
    <name>A0A2X0MA56_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C006g04113 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C006g04113</name>
        <name evidence="4" type="ORF">BQ5605_C006G04113</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY56184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MA56"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="137"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY56184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="233" mass="26151" checksum="A533AEA0B2F22855" modified="2018-09-12" version="1">MGNCSSPHRSGTRLKDQRRRVMLEKCICKWAGSPRAVAESLVSCLGEATADGSAHPHPHNGAEPAYRQEITLIVTGFVRRRSSKAETQGQNTAQSIEWSRANHMVTEMDGYDGDIYVTSFGEDEQEDEDSTFIETSYTVGLNPTDSSVISTCDCPDFVRHMFPCKHMWLAAPIPNSTAEHEDRIQLYRRLAEEAGRVHAKLLRTLQELEADKGRYEEYGETGASRGFEDEFVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MAD7</accession>
    <name>A0A2X0MAD7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C005g03292 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C005g03292</name>
        <name evidence="2" type="ORF">BQ5605_C005G03292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY73423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MAD7"/>
    <dbReference type="STRING" id="796604.A0A2X0MAD7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY73423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="303" mass="33472" checksum="F743C9FF39189CA6" modified="2018-09-12" version="1">MYQHTVVSAAPACGVGVPIRSHVQALWTSPFAQTWLIDPAEATNTRLQGPDSTETRIQSSTLTKLESMLRTGNRFVREFASAKARAGWDTAKEWVLRLCLPPGRDRRTHNLPTSSTEMAMLICDSDTNTGDRGPQDLILQVHGDRCPDGRPKYQTVSSLHPSAMPLRYPLLFPAGEDGFHPNIPLCGSIELGHSSPKDSNKEGEDEEEGDKKNGDGEHKHLWLLLGCSHSVKARAQTDIECLNTYDEGQVKGVKVVSLAFTNPLRSTCTNATSPHGTRRPFPAFVIERYSQAEADRLNYIQSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MCH4</accession>
    <name>A0A2X0MCH4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C008g05133 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C008g05133</name>
        <name evidence="8" type="ORF">BQ5605_C008G05133</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MCH4"/>
    <dbReference type="STRING" id="796604.A0A2X0MCH4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16273">
        <property type="entry name" value="SNM1A-1C-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011084">
        <property type="entry name" value="DRMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF6">
        <property type="entry name" value="DNA CROSS-LINK REPAIR 1A PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07522">
        <property type="entry name" value="DRMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA repair metallo-beta-lactamase" evidence="7">
        <location>
            <begin position="778"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="160"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="345"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="646"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="695"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="262"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="703"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY79443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="949" mass="105016" checksum="BC88875331A6CCAD" modified="2018-09-12" version="1">MTLTSSSFNNGLLPPRSTIHDLFRARHQAEAKAEAEAQAAKTRSPATNQTPTRRASAARNKLTSHTKHTNPSSSSSSSATNRLDRTTIGTSTTKKRKAVAVTPHVDSDDSDIEILPSTLNATATSGGVKRSKVITKEASATDRKNKLSVRAESISIDLTIEDEEEAPSEQVSTNVAATSELNANLDEDDGEGEGHRSRDAAEREQSFGQWNNDDGAHEGEQDLFWDQSDHDDDEPHRRSETPSRAPQAKDEMWGEERMLQDSDGDDVVFADEFDDQPITAIGQQGSSKDLEPVDDHASSNHSTCPICSISLGSMSKKAREAHANTCLDECDDDLVSKPAGRGIFSSMFGKHSKPAPTSTKGKGKSVATPASNGRRPLSSFMPSFSLSAASSTSSSAPGAPNAFTALMTGHAETKQWKLAEEADKQKGRVPKGEFKKVPFYKWVEGLQITVDAFRYNAIQGCKAYFLTHAHSDHYQNLSASWDHGPIYCSYTTANLIKLKLGVKDEYLKPLPMNETVKVHGIDVTLIDANHCPGSVLFLFEGPHTDPNSPYSKTPSRIFRYLHCGDFRAAPPHVLHPAVKNKRIDICYLDTTYLDSKYCFPAQELVIEACAQLVRERVLEGDEEALNRLAGEAEVGMRKGMKGWLSGRGVKKGEEEDEGKGGLGVGKVEDEEEDERVLREMEEEQVMMGEEAEMIKAEQGGGGEDVKEEAKVVDDVKEERKPKLEKEDSKKPKKEKLLVMVGTYSIGKERIVKGIAKALGTKIYCDERKSAILSAQDDPELHALMTSDPLEGQVHMCWLNSVNRDAMSDYHAQYSAKRMEGGYTQVIGLRPTGWTYKAEGSTGEKTPTIAKILERERLRKFSAAGMYPQRDSTSTFLGYGVPYSEHSSFYELTCFALSLDYVRMIPTVNVHTPASRKRMDDWMTRWKAEKKRRADARIPRLVEPRSENYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MCV0</accession>
    <name>A0A2X0MCV0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C004g03029 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C004g03029</name>
        <name evidence="1" type="ORF">BQ5605_C004G03029</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY69535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MCV0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY69535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="421" mass="48301" checksum="9AFF80936CA128C6" modified="2018-09-12" version="1">MRNVMFKLELINRDIAACREDLACVNTIDTNELIEQSTKLQQLAKQRQVLDDRLNSLRASDINISVLDPGTSLPSSILTLWCDPRCPRLNISMPLIGTDYEFACTLIIASRSLWDLVVQYRQGAEKLRLPRLGGKALGRKSMSTKTAGLLVKNLNSLRPRLMKAVAMYNDEMKKYAAILANSEDSHSILRTRRVPPSAPEDLNELLKLDILAPLWNNGLYSHPTEPWAYEDDVRVGIPAVLSRARCQQEIKRLGWEVRRIGRWLISRRKRFQQVRQQSLQRDEQDDSAMMMLEQEEERLRNIARRWFSKGGLDHLWECTRQTGEPQVEEWVELRMWCTDDVDVFQRTTAGGLPDHTWPDCINDGMVGESDITTDHDTLLDISDHSSDDLSHHSVDTTDYGAFSDEVNENFDEDDGDVFWGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MCX1</accession>
    <name>A0A2X0MCX1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C008g05263 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C008g05263</name>
        <name evidence="1" type="ORF">BQ5605_C008G05263</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MCX1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY79970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="163" mass="18176" checksum="E518049E1D4CB638" modified="2018-09-12" version="1">MTIPLLPNGRGPLDDDRGIINAMNAMKTANDELVEKGIITSNEEMSIHFLVDVEEENLAGGAEMTDQEIVELVIAEELEENCEGELEGGGEEAEIELRPAERTTLKEAISALDVFLRFAMNGYSGPAYLISFEHEARRIRRTLVAEQDAARIQTTMTSYFQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MDL1</accession>
    <name>A0A2X0MDL1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MutS protein homolog 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C005g03301</name>
        <name evidence="14" type="ORF">BQ5605_C005G03301</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY73537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MDL1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF122">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="13">
        <location>
            <begin position="1124"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="212"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="936"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGY73537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1281" mass="139507" checksum="A9FBAC5DAF5FE754" modified="2018-09-12" version="1">MVKPAKDDQSQTSISAFFRPRAPPPSTSSNARGIAANSSSSAIRGARKSDGIDGELILLDSSDDDDDVSDASRVPPRPLKRVKLESTVQGPLSSSAAFATSSSAAASSSSTNTMERREVDISQKVSRWQYKPPAPSSVSKTLQNDGAHKPSSSSSTAAVGAGGGSISNGKQRNGAFSSTMATNRLQSINLLKKKNAFLQDQDPLAAAAFESNGYDASSRHHSSTRSQSPLSPFGDGDHDDDVDDGAGTSRTKNKGKVVAKAQGDDDDEMDDGDGDDDGDAVRHSRFRKFAAQGMMAMTKSAKASGIKYTPLEQQVIALRKAHPGVLLVIEVSHRNGAEIALSTRLTHLLTPKVGYKFRFFEEDAVTASRILGIAHFPIKNMMSASIPTHRLDVHIKRLINAGQKVGVVRQKETAALKKADASTRQGPFVRALGDLYTSATYIDPLSVEPLDASSGNAATIVCLVEEARGRDEKVAIGMVAVKPSTGEVIYDEFVDGLMRSELETRLLHLQPSEVVLQPQLSKQTQSIINYLVRQQRSVSRSGFSQVYGRADSKIEWCIEWCSSGASDSTCRIDRMNKKLTIEAARKFITNFYICLKAAGASRKGKETELTRELVIGSDSEDEAEAAPSVGMNGACPSQVLDLPDLVLVALAALISHLSAFDLSTIFFHESSFEHFSSRSTMNLNGNTLQNLELLQNNTDFTLHGSLLSVLDHCHSAFGRRRLRNWICHPLISEARVLERQDAVFEIISSSSNLTISKLRGVFKGLLDLERGLVRIHFSRVSTQELLRVLQAFSRVANVFEAIDEEEERDGAPTPQSTVKSALLKQIVASLPKIKKDVDGFLSRIKSEQAKAGKKAELFHNPPDDLRKVRDCLDAVDIEMGVLLKEARKILKKPTIEFRRVAEEEFLLEIGIAESKKIVPGDWIKINSTKQYYRYRSPQIQAKMDEVNQNRERLEAAADAAFKALLQEITSTSYDAFRAVLSNLATADCLFSFAVTAIAPGYVRPTIVREPGFIKIVDGRHPVHEVLSSQPYVPSSIELGGTATKQMILTGINAGGKSSFSRSVALIALMAQIGSYVPAEECTTSLFDGIFTRMGAADEIGRGRSTFMVELSETSEILKLATRRSLVILDELGRGTSTNDGQAIAAAVLEHITTTSQARTIFITHYPSLAQLVKKYPEVISVHHMKCLEKKRDDGFTDVTFLYQVGPGLASRSHGLNVARLAELPDSVLSKALEKSQELERITQERVASRRAERLAWILRTVGEGAEIASGALLEACANALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MDY2</accession>
    <name>A0A2X0MDY2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C005g03421 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C005g03421</name>
        <name evidence="2" type="ORF">BQ5605_C005G03421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY75356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MDY2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY75356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="197" mass="21733" checksum="D845ACEFE1A4F5D7" modified="2018-09-12" version="1">MGNSASKAAKQHLTKTATSQSPLSSAPTRSSPSSSSSTFTPPSSSRSSEPLASETKSDAIVHDSQDPNFMRKLEQLGQVKLPSAGFAFRAHNQMLDILKQRKEQELQSESLTPIPNRIGARSLSNLLDDCKQAASKQEIQELCKLYQIDYEILTELNRHITAPSTSTIPLPERTVEEDDGETLLVRTWRAERKDPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MEC1</accession>
    <name>A0A2X0MEC1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C005g03269 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C005g03269</name>
        <name evidence="2" type="ORF">BQ5605_C005G03269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY73162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MEC1"/>
    <dbReference type="STRING" id="796604.A0A2X0MEC1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003830">
        <property type="term" value="F:beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006813">
        <property type="entry name" value="Glyco_trans_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12224:SF0">
        <property type="entry name" value="BETA-1,4-MANNOSYL-GLYCOPROTEIN 4-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12224">
        <property type="entry name" value="BETA-1,4-MANNOSYL-GLYCOPROTEIN BETA-1,4-N-ACETYLGLUCOSAMINYL-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04724">
        <property type="entry name" value="Glyco_transf_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY73162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="402" mass="46646" checksum="92C834ADFBED9373" modified="2018-09-12" version="1">MNRINRYLLLCTGFFCMFTVYYILLVPRLPRNLISYASRPLWDTDQRPRLHIHSRLLDLPEGADLRSVCREYGWEERLKAVEVWDAIQKRTSILSTELPMLLIRLTELDPIVTKFFIIESAHTFTGIPKPLIMSTALKTNPDFAPFLDKIHYRSIDGRILAEGEDPFTQEIEVRRAMTTFIKEYMPPRIQGEKDSDIAMGPVLLFSDVDELVSRPTAKLLQSCRFPFPLHLGLKDYLYSFEFEAGGIMKGVSSWRAHATHWPDRGEGAAEYYRHGKVSENILADSGWHCSWCFEKIEEFITKAKGQFLVSIVLGTSRGRYSHTDRLGSRPTALLRPERIQKTICDGLDMFAMLPEAYTWREMASKWKLVPSRSIDDDQLPRLLRKKPNKYRWLFPGGCMREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MEV5</accession>
    <name>A0A2X0MEV5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C005g03280 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C005g03280</name>
        <name evidence="2" type="ORF">BQ5605_C005G03280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY73308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MEV5"/>
    <dbReference type="STRING" id="796604.A0A2X0MEV5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051721">
        <property type="term" value="F:protein phosphatase 2A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035303">
        <property type="term" value="P:regulation of dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.540">
        <property type="entry name" value="TAP42-like family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038511">
        <property type="entry name" value="TAP42/TAP46-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007304">
        <property type="entry name" value="TAP46-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933:SF9">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04177">
        <property type="entry name" value="TAP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY73308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="426" mass="47603" checksum="4BFEDE01C5F34FA2" modified="2018-09-12" version="1">MSSTYNEADSDLTLGQLLTRSLASANIVLNADSPNELAMQNRIHSTLSDLKLCSSLISHLSILSPNETLEEVQTRDLRCLLVDALSAQLQVLVKTKGAVERMQWLQQAKTLFASYVALIDRYQVVAENQRSTFAGPQHATQDPTRRRESKIAQYKMEKEIKNKLDVSWELRKRRNEQRTKARGTRISPTSSSMTATTSSSTAPTTIEPDPIDDDSYDSDDDETEVARPLYIQLLLQHYVRAHAELASIEQELELLSHGMKMSDLPSGPSGSGSNGNGAQGKSREGEDDTSWRLDKVDRGAQGPLLDKEGKVLRPFTILPSSKSSTGGLLSTRLRLQSEVFRSGHRLPTMSIDEFLDQEQERGNILQGGGPSSSDAVDQARRDEQAEKEDDTQAGYDREEKELWKAREWDDYRDAHRKGEGNMHNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MEZ1</accession>
    <name>A0A2X0MEZ1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C008g04922 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C008g04922</name>
        <name evidence="1" type="ORF">BQ5605_C008G04922</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY78714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MEZ1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY78714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="201" mass="22248" checksum="ABC370DB86E2F0FE" modified="2018-09-12" version="1">MKHTKFVQHVRCIDAGVITDLTRDHFEGLCEGGDDELLFTLDRARRVAQRTGMTVEKHGLQLTSVAPPPATTWLFLIALLTIMMASCKLLSTSEMNCSAPPLNNNVHVWALTQPSKRLNLSPPICFSSNLSHVPRCSGRISEHVDWIEPPTAETTRFKSSTATRPAQKMSRSAKNCVARSPIGKRERITWAPVLCRASSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MFI0</accession>
    <name>A0A2X0MFI0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C014g07537 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C014g07537</name>
        <name evidence="1" type="ORF">BQ5605_C014G07537</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY19017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MFI0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY19017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="49" mass="5250" checksum="511DAC80FB2F5D48" modified="2018-09-12" version="1">MYVYSGPLLRNSSVSALDDVVDKCSLGQLEPACERAIPTSAPLVVRSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MFK2</accession>
    <name>A0A2X0MFK2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C014g07567 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C014g07567</name>
        <name evidence="8" type="ORF">BQ5605_C014G07567</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxisomal targeting signal receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY19123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MFK2"/>
    <dbReference type="STRING" id="796604.A0A2X0MFK2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005052">
        <property type="term" value="F:peroxisome matrix targeting signal-1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024111">
        <property type="entry name" value="PEX5/PEX5L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR PEX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130:SF9">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 6" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="566"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="600"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="14"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY19123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="728" mass="78552" checksum="41B681188A623F8D" modified="2018-09-12" version="1">MTLAAVAFQSMMSGAECSTGASPLSSLLKQQGQDHSLHQSGLSSQPGPPSSMRSGGGGMHQSMPGQMRPQEADRFFEQSGPAGNASFGDLQGLRRELDQVARSSNPVLKGDQGQFEAGCHRYASLDDVAPELGLLRGIGRADEFQIHDPTEWASQYQPAGASLNPVDMAQMEQSFRMQHQGAQPNELSAEFWRHQQQQRASPGPSIQTRGAGGTGGSAAYARSGFAPSYGAYGGGMSMRSMPMMGGSGAGGMYQPSPTVQQDVKGKGRFVELDDADWEAQFARAGESAQEPAEVVTEEAEQKDKIIDDNAAPLDTINLLDGDLDIDASESDAELLKELEKTWQNLQGTLQESSSISDAEMAAWEAQYGSQFVNGDDGEFDLPDMRKIWTKDNVDGFLQEDLIYPYATENEYLHHPDPFAEGQRLLAEGARLSEAALAFEAACKLDPSRAEAWKAAGETWAADEREVKGIRALEKAVACGGPDGVGAWMSLAVAYVNEGQELRALATLEKWLTLAYPTLSAKPGPLPSATNPWDASNRIIDLFLEAARAGPMARVPGQSNELTEVDPDVQVGLGVLFYSNSDYERAKDCFESALSVRPTDFLLWNRLGATLANGGLPEEAISAYRKALDLRPTFTRAIYNLGVSCLNIGCYHEAAEHLLAAINGHMTREKNGSGSLAAPDGQPVDDEDGSANLWHTLRRAFLCMERHDLADKAHAGTTLDEFRSEGLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MGI7</accession>
    <name>A0A2X0MGI7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C017g08449 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C017g08449</name>
        <name evidence="2" type="ORF">BQ5605_C017G08449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY20054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MGI7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="589"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="431"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="511"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="598"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY20054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="802" mass="89199" checksum="2F338B1E9C50AE2E" modified="2018-09-12" version="1">MGQMTAFPDDPRHRPSASEICPLYDNTRTIARHAPRVGQSKRGALQDDLHSVVRVIADVDHQLVVYTKYDSGFENPLLASDRDPDPRKQAKTEPERKRRKAVSTISGRSSDPDAKASSDMLIGIQTTLMRERLIDSIAEEATDGNIGWPTDAHNTFYRDKYVLLATVCYSPSARPSFYRQHFLQLFKILNDSKCTLDEIVNGVAFVVDYSAAQLFGLRQAIVEWYVGRKIADVGLLNVTDDQKKQWTAVAIKIGERVAKGCAFHFIEQVRRFGLKHFAESDERSSHFASLFIIEKVPVAESWIKWWTRPAIRSVVFNNLSGTANNGVATTTNAVESSHWLLIHSCGNERYGPVEGVMRLLDFANLTDNIDMHAADVYVKSSTYHERGNTRAHMKEIKERKEVPSSYISDANMSEASVAFASPARYPGTGVSKSSKAPPSSLSRPMPVSPIEIDDLITIDQLAHGSNPSIREAKVNCARSSSRHVESCSTTGRPADCSTKPKEASISKSRAKSSGRPSSGAARSIRPTPLSVRALNEWTEERSRFLALFEKPQSSGKNYRVPRKRMIAALGKPESDLAVAHFQPVPNSGFARPKAADSKSLSTSQASLGLSPPKAVSSSTPLELQSSTIATLHEDFWLRSEQQCSKQIGIVQGPWHNHSCWLNSALVGLLSVATGLKEWLIHMDCLFITNPSMCAKLEMEETFALQGRTLALEIWSLIREYTQLAYDYDSKPVKDASNAYFKLRERIISLVIVLSKERKSDYTTPLKRGEYSNPSSWLVSLYTFTVDHIPIPIPRDHLPTSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MGS9</accession>
    <name>A0A2X0MGS9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C034g11361 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">BQ5605_C054g12622 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">BQ5605_C115g13250 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C034g11361</name>
        <name evidence="2" type="synonym">BQ5605_C054g12622</name>
        <name evidence="3" type="synonym">BQ5605_C115g13250</name>
        <name evidence="1" type="ORF">BQ5605_C034G11361</name>
        <name evidence="2" type="ORF">BQ5605_C054G12622</name>
        <name evidence="3" type="ORF">BQ5605_C115G13250</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000065">
        <property type="protein sequence ID" value="SGZ00609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000093">
        <property type="protein sequence ID" value="SGZ29343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000101">
        <property type="protein sequence ID" value="SGZ30109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MGS9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ00609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ29343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ30109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="105" mass="11204" checksum="71FBCE62931FD514" modified="2018-09-12" version="1">MTTPLISVRVRSVVDDSTDIPIATGVPITSISTSSSSSKALDQMLRFKGVVVNTNVGASQPRVSTIKAESSSVQLVFSVPVRMTPPLPLNVTAKSVSFHFPSIWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MH95</accession>
    <name>A0A2X0MH95_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C016g08197 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C016g08197</name>
        <name evidence="6" type="ORF">BQ5605_C016G08197</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY21110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MH95"/>
    <dbReference type="STRING" id="796604.A0A2X0MH95"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024957">
        <property type="entry name" value="Cep57_MT-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06657">
        <property type="entry name" value="Cep57_MT_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cep57 centrosome microtubule-binding" evidence="5">
        <location>
            <begin position="728"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="124"/>
            <end position="199"/>
        </location>
    </feature>
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        <location>
            <begin position="243"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="523"/>
            <end position="611"/>
        </location>
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            <begin position="688"/>
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        </location>
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    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="377"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
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            <begin position="181"/>
            <end position="190"/>
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            <begin position="292"/>
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            <begin position="317"/>
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        <location>
            <begin position="523"/>
            <end position="536"/>
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        <location>
            <begin position="576"/>
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            <begin position="688"/>
            <end position="699"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF06657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY21110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="819" mass="88448" checksum="B1CED7D0A0CEB455" modified="2018-09-12" version="1">MSVAHTPSQMRQQRYPLDTPTPASSSGHHSTLITSLKPSRSRSNLSSEIKRAISQHAQPPVNRTAFGNLNGRFAAAPPPSSSPAYASVPRVIEEEGGILTDNTERERLDLENEIRLGMGELNRQAGGLRSGASSSGDSIGYGDLSDDLEQAHGGLRQQTSTLPRQRHHQQHQGLRARIEDESSGAEDNGESSDPTIGDDFSLRIGLAGNRASSAAAHSAMPTGSAIRAAARALDQEDLTFTGMQRSPAASPPFAPAAAAARPPPTDENRPPVTAAGPSSSFMPAASKTFPLRSPSNINNAASRASAIHSFSPKMGPTYSNRSRVPSSTPHFSEPSHRLPDVTGLTDGLTSPARSRNQHMAAPVPRRPNSGQAVGSEATAVANAIDDLRSRLQDAEAVNAQLMRALAEKDQTPAVGVRRASPAFVQAPAQSSPGLTRREVEDMFLRRDQESTLRARLTQLERQVASHEIAIAQLRALPRVNEHDRQRVSELNERLKTMLTETNVVKNAVEELLHDKLVKEQWEREEMSRKREMEGHHLRTGGSTPPPGQMAATANVDPDRTPRAQRTTHRWAAEPTTIPPPQPIIRPATAPPRQPVHARAAPASAPAPNAAPVRACAAPQPTHNEAAYDESYASTADSSIAANDSASTAASSPMLEPDFRRAEALFESMSMQDPSKRRKNICKLCGNGLKKKKAQGPRRRGNLDVGGNANEKDLGGAGPNVQNAAPAAAPAVDHKLELRSTLEKMEQAFAVQKQLYIELSEQYRAMDSRVSDGRRRMLATHLKDSIDVLETMAEEIQKFDACFHRFTTSQGHGRMREGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHP8</accession>
    <name>A0A2X0MHP8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">BQ5605_C009g05813</name>
        <name evidence="22" type="ORF">BQ5605_C009G05813</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY86371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
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        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
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    </dbReference>
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        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
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        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
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        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
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        <property type="entry name" value="Chromo-like_dom_sf"/>
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        <property type="entry name" value="Integrase_H2C2"/>
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        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
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        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
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        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
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        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
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        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
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        <property type="entry name" value="RT_RNaseH"/>
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        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="DUF4939"/>
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        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0229">DNA integration</keyword>
    <keyword evidence="16" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="20">
        <location>
            <begin position="654"/>
            <end position="833"/>
        </location>
    </feature>
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            <begin position="1203"/>
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    </feature>
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            <begin position="1039"/>
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        </location>
    </feature>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="SGY86371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2026" mass="229395" checksum="6BBB028F368FABC4" modified="2018-09-12" version="1">MEDLTQASLDSLIDQLRTLQARNQALEAECRSHLSDKENYQITVTALANQQQTLSDFAKAVVDQQKESIDVIKSGLANLNVTAPANTTITPVKSQLPKPDKYDGKEKVKFKTFITQIKFYIFGNPSSFPTDKSKIAFIISHLTGDAFQHFEHAINAKDNSKPEWLTNYQKFLDQAELVLGDPDYRNNLTRQLMSLVQSGPASVYASKFTQISSQLDWNQAALIAHFHKGLKLDLQAQLALHDDPQDLQSLIELAIKVDNKLHLARHRTNASTQFRQTNWQYSHSVNSPLRTSPVSQLQANPSTANTSGPAPMDLDATRSRQGPLSEEEKLRRRTNRLCMWCASDQHLRDQCPTAPPMIPRHTALNASPRMSCTGTLFPQVSSPPSPRYSQQNSTRFPKTTLFCPSYSISSPHPNLATSFVHDNHLQLIAHPTPIPLYVIDGRPIQSGNITHFVHLEVQFNGHTQSLRADVTQLGTYPLVLGMPWLRLHNPIIDWKRNTLVYSCQSCALGHTQPINVSIEGAPLVPLDHKHLDISFASSFAFERLVNNSDNHHGLLFYDPTSHQLSSSSPAPSQSLSDDNQDSLEYLESLKNLVPSEYHHLLAAFSKVKADQLPPHRKFDLSIDLEDNTTPPFGPLYPLSETELQTLSSWLKENLSKNFIRASTSPAGAPVLFVRKKDGSLRLCVDYRGLNKITRKNRYPLPLIPEALDRIRGAKIYTKLDLRSGYNLVRIKEGDEWKTAFRTRYGHFECLVMPFGLTNAPAAFQHLMNSIFRDLLNVSVLVYLDDILIFSGDECQHTRHVQEVLQRLINNKLYCNPKKCEFNRTSTEYLGFIISPSGVSMSQDKVKAITSWPTPTSLKELQQFLGFCNFYRRFIEGYSRVIAPLTRLLKKNTPFLLDSAALSSLDRLKQIFTSGAILCHFNPLLPSIIETDASDFAISGILSQVTDGHLRPVAFMSRKMLPAKQNYEIHDKELLAIVECIKIWRHYLEGSQHPFKIYTDHAALQYFQTKRVLTRRQARWSETVNHHKYTIKYRSGSKNNKADTLSRRPDFSEGGKASEQPGQILLRPYTLAASLVKFSPPSDIVDLIKFHLSQDPVSNQIVNDLNHDSTLHPYFKLQDNLLLHHDKIYIPNAEPLKVKLLAQAHDSLLSGHPGQVKTFELLDRNYTWPGMRQFVNNYVKTCDSCQRNKPTHHRKHGHLQPLPIPSKPWSSLSMDHIVDLPPSSGFDCVLVVVDRLTKEAHFIPTHKTDSSRDLARTFLTHVFKLHGLPTDIVSDRGATFTSNWWSEFLAMLKIKPNLSTAFHPESDGQTERTNQTLEHYLRHFCDYLQTNWSELLPLAEFAYNNSFHSSIGASPFYVTRGYHPRLEVSLRDSFVTDVPKYLQHLRSVQETARKQILQAQETQARFANLKRKPSPPFKIGDQVLLNRKNIQTSRPSSKLDSHKLGPFRIQRIISPVAFKLELPASMKIHPVFHVSLLEPYQANSLASRCSNPPPPPEIINGEEEYQVEQILDSRNNRRSRRLEYFVDWTGYGPQDRQWVSAADFDDDDSLVIEFHTRHPHKPGFERIQGLNGARASSYLYDLAPRLLPLASTCFHEFLSLSLGFPATINRASVTTTSIPHLVPSSSLSPAAYGSATSTLTWPRLQTSCDAYVSTCDVCQRTKATTTGALGVSHALAVQDGLMQEVALDFVGPLPKSQGFDMLLTITDHLLGYTRLIPSLAVDTAKDIAERFHEGWHRFFGPPTRIVFDWDKLFTSHFWRAYHNLMGTRLAMSTLFHPETDGRSERTNKTAIQALRAVVNKQQNNWVRHLVNIEFAINASTNKLPFEVVLGCSPSLLPTSLNRPDLPNVPAAKDLIAERKAVLVEVRDALAAAKVRQAEQVNRHHRPEPDIAVGNFVMSAKLFDRFEGPYKVIAANVATSNYTLQLSEGNRSHPTFHVSKLRPYQANDPNLFPNQEPARPKPVIVNGHEEWVVREILEETTKGGGGKRYRVWWEGYPQHEATMEPRENLVGTEALRCWELKKRMEGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIQ4</accession>
    <name>A0A2X0MIQ4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C028g10502 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C028g10502</name>
        <name evidence="3" type="ORF">BQ5605_C028G10502</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000080">
        <property type="protein sequence ID" value="SGZ12398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIQ4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016002908" evidence="2">
        <location>
            <begin position="19"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ12398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="235" mass="23576" checksum="9ACDF00F1D9F013E" modified="2018-09-12" version="1">MKTSVLALPLLAATAARAVPLPAPTFGGAAMWDPMFWMKKWGNMLGGDAGLSGMGDLSKWANGLGEISKWIKYAHDTLRSTDGSTGTSTSTGSGGGSGLAALEKIASQVMVLVALNMHTTLTQAMLHPSAYMTGSKGSGADSTANTAGESTGSTSGASNSARLIRGLNTTPPTGGSSGTTVSKAVVSGSTPATEAQRASKANALARDKVSVQGRTQKAALNKTTTPTVPTTGTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJT5</accession>
    <name>A0A2X0MJT5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C010g06114 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C010g06114</name>
        <name evidence="1" type="ORF">BQ5605_C010G06114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJT5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY14239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="83" mass="9473" checksum="5FA90C4A71DCB383" modified="2018-09-12" version="1">MHHAERMRSVVLSSQEALEVMPSLLVEEQLPPSMNLGMDWTFWGHFWAKIPKNGGQMRSKIGDFPGFYLRASGWAFMGPPRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKL9</accession>
    <name>A0A2X0MKL9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C030g10778 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C030g10778</name>
        <name evidence="2" type="ORF">BQ5605_C030G10778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000069">
        <property type="protein sequence ID" value="SGZ08210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MKL9"/>
    <dbReference type="STRING" id="796604.A0A2X0MKL9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ08210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="321" mass="33888" checksum="002681864968DA04" modified="2018-09-12" version="1">MPPLAAALPRGNPAGAPHSANEPVPPHTSTPTSAAPTTTEDATSRWEAHIRSEWLAPPAPFPSSSSSCSSVVSNRGSSDSSARTGCRKGRPLDPVFRERLRQLEQMLRLDGMGTEEGGSDGPNVPTGSRSHAPAATAAVVEDAESPNRSVEVGETPDGGDVIGVVTGRRNELKKANEGILLAFKQGRVLREPLPLSLVTALLYRSCLMPYFLSLLREMDGTIPVDYVAPISGNPLPNGSSQVRAGQDHIKHTDTETGKRGETPLPKVCSGAGGRSEWPGVPGDAGQDGAQLGDLRPKMKMDRLKGARWRTEKEVASGSDVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKM6</accession>
    <name>A0A2X0MKM6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C002g01415 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C002g01415</name>
        <name evidence="3" type="ORF">BQ5605_C002G01415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY32844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MKM6"/>
    <dbReference type="STRING" id="796604.A0A2X0MKM6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="322"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY32844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="443" mass="47876" checksum="F3E7CA1962DAFB28" modified="2018-09-12" version="1">MYGLTPPASAAGAWAPSVTETWDTTRNDQHHEPAHYVPHLDSTMYQSDWEPHHGHYDTYSAPQHPHPHHQHHLSVGPFAEAPAGPPVTAPIARASSAGVDHHRSTSSPSHFYDRHDVSRMSSTPMISHPSDPPWSDPSPLQDPHLAAARHSPALVSAHPSGAPYATSSSTSYRTAAMSHPPPRPTASALASNSLNHVRVGSNASTSAVSYGSERLSSISPPVRGSDGTLSPSTTVRSDSSSDEALKQDKTPASSFFDLSPSSLSAMAKNPTVNATAPGRGSSTLVAAESPKRSYPGAKRGRKPKPPPSSEEAKRNREICLKKNRIAALQSRRRKKIKNGQLENQANELMLRNKSLQIFARDLHVELMQLRALLARLPGGFPDVNAYLDREAQGGGIPTIMRIAGPTLEHSIIHSCFFPYTSFTYIVFFFKSPITVNALGLLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKN6</accession>
    <name>A0A2X0MKN6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01425 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01425</name>
        <name evidence="2" type="ORF">BQ5605_C002G01425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY32954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MKN6"/>
    <dbReference type="STRING" id="796604.A0A2X0MKN6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37449">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37449:SF1">
        <property type="entry name" value="OS02G0159950 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY32954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="212" mass="22307" checksum="3B130C78A3658141" modified="2018-09-12" version="1">MTMWSLVPKPSISTSSWFNVDSRSSLPPNCPPLPRLLPMASISSMKMMHGAFFLAVANKSRTREGPTPTNISTNSDPETDKKGTPASPAVALASKVLPVPGGPESIAPRGILAPSRSYFAGSLRNLTNSMISSLASSMPATSLNLTLRSVSGLNILALLLPTPKMPPGPPPPPPPIADMPPAARFEIQKSRPARMNVGAKCSTVWPSGVSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0ML86</accession>
    <name>A0A2X0ML86_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C023g09656 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C023g09656</name>
        <name evidence="2" type="ORF">BQ5605_C023G09656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ23896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0ML86"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ23896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="115" mass="11583" checksum="FBE99CCDDF8EA05D" modified="2018-09-12" version="1">MTTNAPTHSDKNVLISPSVGGAGPTHGVSATGSNSSSLNDRTGETTVGEKIQGLMGTLHGAGEAIRGTINGALDGVGDVIAGREQGSVPARRNDGDNVARKGVEEVKEGYAKLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLV8</accession>
    <name>A0A2X0MLV8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C029g10672 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C029g10672</name>
        <name evidence="1" type="ORF">BQ5605_C029G10672</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ15442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MLV8"/>
    <dbReference type="STRING" id="796604.A0A2X0MLV8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ15442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="576" mass="64575" checksum="EA20D0A475B9D0AF" modified="2018-09-12" version="1">MQLLSRFFRKRSADNTDDIMKQLAKLSGARLQQAKVIPSSDNTAVQILIDLWHFFDRIYVSKKHGAAKAFARAFSDAVFIPNADDRLLIKARLAKLGMTWEEAVRSPVWNKKLWRRVRRWIPPPGILEPLVREVFEKLGRCERCLEAIRKGQVSDPVGIELYTDLGPCGGPDGKADDGVRLYSCQRDTNSLEGGIHRNLRQRFPRSGVSPCHVNACTADYVLVHNLTVSPTPPSQFEEAATILTHSPLYSQVGTFNRTGKPFVGHYDLWLTVELHRLRRKTTASFPRHSITVSDIVNSLLYTPSTETFGIVPVVQSPTAQMRFLIEPYQVERGTLRLEPVKWSPRNLLQNNTPAIQHMQSRLPTDRKLRHDWLAERQGTRFDVLYDWELLKNFRILEITELWNKYANGVDIFYKMPEHINTWASRWSSLANAQATMNMGGNDVIVIQALLTDPSRGRDVSMLAAKPLLGHKPPVLGRLTEVEVDFSDPPTSSIRALVATASSDVGSSADLGTSSALTRAGTTKGARHCRLCGQTTCRRKGSKLSDDGSVTECDGACLDCGKHRRDGSERPTITKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MM90</accession>
    <name>A0A2X0MM90_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g01927 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C003g01927</name>
        <name evidence="1" type="ORF">BQ5605_C003G01927</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY37959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MM90"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY37959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="35" mass="3944" checksum="AD9798A503389C98" modified="2018-09-12" version="1">MLPACNPGCWMARGLAQHEGWCGLQHVHLIEKKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MME6</accession>
    <name>A0A2X0MME6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BQ5605_C025g10039 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C025g10039</name>
        <name evidence="11" type="ORF">BQ5605_C025G10039</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the type 2 lipid phosphate phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000087">
        <property type="protein sequence ID" value="SGZ27052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MME6"/>
    <dbReference type="STRING" id="796604.A0A2X0MME6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03388">
        <property type="entry name" value="PAP2_SPPase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF28">
        <property type="entry name" value="DIHYDROSPHINGOSINE 1-PHOSPHATE PHOSPHATASE LCB3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="10">
        <location>
            <begin position="177"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="468"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="473"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="486"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGZ27052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="590" mass="64894" checksum="59BE752A7579EB50" modified="2018-09-12" version="1">MAPPRTSNVAQDPPSVDVSTSSSTTSPLLLPSPSLATLSTPTYDIPIAAFTPLDTPTISTSSNIHPLTSSDTDVVYSPQELSQSLQQNPVEHVRELALGRLSDQTYATLLPAWRDRLRKLLVRNLQREMGTLVWIQASLRTPARDDYFVKTSLLGTHSFFMICVPMPFWFGHGSVGRGLLYVLAAGGYTTSVLKDLLCVPRPYSPPLVRLSVGTHALEYGFPSTHSTTTVSMALYFAGLLWHSGFENSLVNLVGYIVLAIICVSVVFGRLYTGMHSITDVIVGTLMGVLCWLWYYVYETSVEHFTLRNGPLVPLIMVPSTLLLVFVHPAPAEDCPCFEDAVAFVSVAAGIVLAHHFHPRELLGETVRWGVGKGWGESVLQLVWMGTVVLKLVVGILTIFTWRLVAKEVCHATLPPLFRFFSSFLLPRRHYHDATEYDAYQKTEGLHPVPSIIDLPSLNDLDLDPTTTPLTSSYTGASSPSFKNQLRSRSGHSSPSPSVMVDETDPLGLLRQKQKREIEGENGEGVGEGYEKLSQSTSKKDGDRVRRDADVLTKVFVVSTFKVYSGIGWFATIGIPWAFEHVGLTIPPSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MN46</accession>
    <name>A0A2X0MN46_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C015g08004 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C015g08004</name>
        <name evidence="2" type="ORF">BQ5605_C015G08004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY18198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MN46"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY18198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="607" mass="69422" checksum="6504C3009DA5CE81" modified="2018-09-12" version="1">MPVSRGKLTDDLEGQEDVPFLDEESKDARNDSFAFGDEEALNRTRFDESQHNSTHDYPPASPNTSPQSHSWVHEFKHGKWRRMVVPSIMLYLLYASYTLFRTSGPSDWWWAKSSPVVFDLLDPTVYVKTPGQSLLDRGKVNWEAQLNANIFIFNAGPFTLNHPTDEVAWTAQAGEPFTLTVQCDATIVGTEECSPQYVVHFRGPVSEAVPSNPALYKHDLKTGTTEIRHTLIQAGFYDIWITPEVIGNPDCSENDQHWTVKGSGQRPLHVVEAPKSSRLVSDGFRECTAVDYEGPAHGRWISVPHINPKYRLTPWLQNTNLTTTDQYIYVPYRCKQTRLDVKHSLEELPSVKHVAYIGDSILRTSFCGHLYPSLHDGQIGGNCLYSDDLKTYHYSSKTFEYSFSNITKDTHRGVVRFSQRFLTDEFDKWQDTLADLVGPGVPPLTHVIVNVGLWLALIGEEAYMQRVSELLDYVQAVTSPSVHIIWASTPSVSPGIVCYNMFKRRGLRHHGILAQRALGIFRERFPLLKVDFIDYYRLTDARPETSTDGRTRLACFTYRHWVREDQPIPWMYEVRPWVGAADNALFQWAWDIWRVRAEDDQSARVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNI0</accession>
    <name>A0A2X0MNI0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Class E vacuolar protein-sorting machinery protein HSE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Class E vacuolar protein-sorting machinery protein hse1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">BQ5605_C021g09307</name>
        <name evidence="15" type="ORF">BQ5605_C021G09307</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the STAM family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000083">
        <property type="protein sequence ID" value="SGZ20861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MNI0"/>
    <dbReference type="STRING" id="796604.A0A2X0MNI0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16978">
        <property type="entry name" value="VHS_HSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF3">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="14">
        <location>
            <begin position="17"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="243"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="153"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="403"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="501"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="605"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="722"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="160"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="407"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="449"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="502"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="559"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="629"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SGZ20861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="862" mass="93912" checksum="6E868BB0A3F62524" modified="2018-09-12" version="1">MFSSKTVNPYEAVVAKATDEKQTDANWDILLTVWDKVNEDGEQGQNVNTNFLRITRRARNCVAALQKRFVHRSANVHLFSLTLAGALVNNCGPPLHREISSKAFTGALTRLITDRSTHESVKTSALSLIQAWVKEHPNNPDFDILVETYEQLKRQGQKFPSDKPEPKPDRSRTDEALRREEEELQRALEESARLAGVGNSGGGPGRAQDYESKALPRQPSTNGLHEAYQSHASTSTSSLPPPRLPQRARAMYDFAGGQSPEELPFHKGDIIRVIDSPYNDWWRGELRGATGIFPRTYVVSLCEVELPDTPVAPPSSQSSEAELEAELFAQSANIDRLLNMMRTLSSRGENVAENEELGELYNELMTLRPKVVSLIKKYDQKGAELRSMNDKFGRAKMTYEGMVGYGHPSQSPHGNPQQQQGQGQYGGYPDPRHQQQQQPHPSYGVPGTQGHQQHPQQQHQSNFAQQRQHEEEMARKEADARAQREYETQMAQYEKEMAAWRAAQEQSQQSSYYPSQDYQPQQQYAPTPNHDPAYPQPHPQQYDAPAQHGAHGFEPPPAAASTQQWAAQTPSHQQAPVLAPSADPNQPVWDGSQWVYPRQHVVAEASPAAGPTQTYVSAPVPSPAPISSPSPTVAAVAPQMGYPAQSQSYPAQPYPATMAPYSASAPVPTQSPPPPTSNYAMSTTSSIYTAQSQPLNSFSQTLTPSTTATPGALVDRMASLSVSTPPTHEPQPQTSSASSLVSADTIRHQLYDRPMASSTTYADPNAAVASSHAVSPPSTAVAPAQVYYPGPVGAVAAQPLEAGAPAAVENNAEAGADDAAWQEYYRKKAEWDQQQAQAQAAAAMAVVGVPPQVSGSGLPQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPI5</accession>
    <name>A0A2X0MPI5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Palmitoyltransferase</fullName>
            <ecNumber evidence="12">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">BQ5605_C048g12385</name>
        <name evidence="15" type="ORF">BQ5605_C048G12385</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="12"/>
    <dbReference type="EMBL" id="FQNC01000110">
        <property type="protein sequence ID" value="SGZ30500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MPI5"/>
    <dbReference type="STRING" id="796604.A0A2X0MPI5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 11" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="521"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="571"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="122"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="156"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="224"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="257"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="14">
        <location>
            <begin position="473"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="761"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="772"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SGZ30500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="781" mass="84336" checksum="BE9A99B97CF865A0" modified="2018-09-12" version="1">MAPPPLATKTSATTSATIVEHSATPLARTSLQSTSAHGNASGATSPPNPDHAPAYDPTSPTEPHESHEPFTASPPLPQLHHAAQIGDLTALHSLLPEPNDAPSTTATADGAPTVTANDLDPVGVTALHWAAINNHVQACKFLLERGANVDAIGGDLSATPLQWAARNGHVYVVHLLLKYNADPTLLDSQSFNALHLSVHSSSALLVAYMLFTSQPIAVDSADTEGHTSLHWACYQGDAISVDLLLRAGADPRRPDGAGLTPLHWAAVKGNAACIKRLVEAGVDLSVKEHAGKTARDMAAELKSLAAFKRGLLDAGYHEDGRKQVGTLSPRNTIVAIFIVPSLAFVVILQSLVILPWWSGLLLAFGEIYGMHHIVAKVLLGVSGPHNSDRITKSPYLASIITASLLAATYIYLTRMVSLPGHAVSQLLCGIGILVCSYNFFRAITLDPGHVPFPVNDSELKETIEDLVEHGNFNGMNFCLPCLTRRPLRSKHSYMTKRCTARFDHYCPWVWNDVGSNNHRQFLMFVIALVFAISVFLKLSYHYFSTLAPPLPPDAVCNFPNWLCVSSRFDTLALVVVSWSGLQLTWTSILLVAQLWQVVRQMTSLEVSNVGRHGYMGGKPGVSIAAQQGLVATRTAAALATSSTHATVDREVGDEEAVNHKSTRVRKGGFLLKILGIDRFTTGQAVTGLAKSGHVANPFDLGLVGNCRDFWTRGKELDVDYTRLHEIPEGGFQKAVRERRRREREEKAGLKKAGTTAMSTVRGAKANKSGRTGYERLAMDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQH8</accession>
    <name>A0A2X0MQH8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00362 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00362</name>
        <name evidence="2" type="ORF">BQ5605_C001G00362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY45944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQH8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY45944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="106" mass="12361" checksum="692CE769CF4615BA" modified="2018-09-12" version="1">MRDTRELTRDTRADSRGRLPHTHRPHVNLAQLFPAFITTLFHSKAFNCYHEKSRWASFRLGRGSWPPRVQMQRFFQCRCSIYDSAAAYQDSWPGAPAQDLSAHPDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQJ5</accession>
    <name>A0A2X0MQJ5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C025g10043 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C025g10043</name>
        <name evidence="5" type="ORF">BQ5605_C025G10043</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ACBP family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000087">
        <property type="protein sequence ID" value="SGZ27066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQJ5"/>
    <dbReference type="STRING" id="796604.A0A2X0MQJ5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF62">
        <property type="entry name" value="ACYL-COA BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015887458" evidence="3">
        <location>
            <begin position="20"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="ACB" evidence="4">
        <location>
            <begin position="77"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGZ27066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="164" mass="18544" checksum="B4CC8731177A668E" modified="2018-09-12" version="1">MKLLLLLSVLASALHLSMAVAVERRAGILARGMRAWANCAGRVQPSPVVCSVPSDPTQDKIYRQFVKSKIFIDMVAIWRDDYLVEFGKKESMYGLYQQGSIGDVNIEQPWAMVMVARSKWDAWNRLQGMPCNEAREQYVKQALVFADSMDQKIIDQYGKPIVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQY9</accession>
    <name>A0A2X0MQY9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C027g10347 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C027g10347</name>
        <name evidence="2" type="ORF">BQ5605_C027G10347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQY9"/>
    <dbReference type="STRING" id="796604.A0A2X0MQY9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ28469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="517" mass="57770" checksum="57CC558299368AF3" modified="2018-09-12" version="1">MTKCSSWQSYLGQGCNKQRSILIDLWHFFDRIYVSKKHGAAKAFARAFSDAVFIPNADDRLLIKARLAKLGMTWEEAVRSPVWNKKLWRRSKQPLFNKAAHEAAKRCLEAIRKGQLYTDLGPCGGPDGKADDGVRLYSCQRDTNSLEGGIHRNLHQRFPKSGVSPCHVNACMADYVLVHNLTVSPTPPSQFDEAATILTHSPLYSQVGTFNRTGKPFVGHYDLWLTVELHHIVNPLLYTPSTESFGIVPVVQSPTAQMRFLIEPCQVERGTLRLEPVKWLPRNLLQNNTPAIQHMQSRLPTDRKLRHDWPAERQGTRFDVLFVHTPSERALYRYLSSKVRLGALQNLQIFEITEPWNKYANGLDIFYKMPEHINTWAPRWSSLANAKATMNMGGNDVRVIQASFADPSRGCNVSMLAATPLLGHKPPVLGSLTEVEVDFSDPSTSSIRAFVATASSAGSSADLGTSNALTRAGTTKGARHCRLCGQTTCRRKGSKLSDDGSTRWIRTTHNHEGPIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MR58</accession>
    <name>A0A2X0MR58_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C026g10264 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C026g10264</name>
        <name evidence="1" type="ORF">BQ5605_C026G10264</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ28054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MR58"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ28054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="651" mass="72251" checksum="A5A79C97DBD375C5" modified="2018-09-12" version="1">MPSAEIRPAPHLTQLPRLAADLHPTLSTRIRLAVTQLNRLGHDSRSTGDLDRFTRTPIGPNLPSTKVDVIIKSASDLRDSLFAKLFPYIASAREGSRSFDQLIDSFTRPKGILLPCSNKYLRVSEKIFPPKRFVSRLKRYPLDPQYALHLITTLKKVHLTTLPILIVHAGPDDLSPDNQRKLKSLSPDVEVFDLLDVFSEHHVGILDGGARDYQIHNTTNHQGSRHVRISEHYVRKRVAEKEIDVVYIATADMFADIFTKALGPKPFLFHWENLGLRGTVPRASSLPSARALGSSLSSPTIFTTIFGSRMLESLLQQVMSSTGKSDFPNGSGNCLYLKDTQGYKSWSQRAFINLRADKVWDVVNQSIDSLVADYWSTLVVAHATASVAPVEPASSGFSGLGGGSGSAHSDALPRLTSVQVADKVAEYRERAIRRNDLACKYIANSISEEQMSHLIHLTSAYEMWDTLRGLHSHGRPSRTMDLLNTLAQPYSGDIRFKEFVNKVKIAMTNFQNLGAPLPHWLFAGMLVRSLPAQYDSIVGNLASDIDIHMDWNTFYPKLLMNVKMADSRNKQKELLSARIVDNTSLVARISTTAQKDYSKSDCSRCKALGHERGWRLCPSRNKDASAPASSDSNSNVAAIGVDESALMTYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MSW8</accession>
    <name>A0A2X0MSW8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C006g04018 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C006g04018</name>
        <name evidence="3" type="ORF">BQ5605_C006G04018</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY55408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="903"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="292"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY55408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1696" mass="186813" checksum="FA28F2ECFA42D829" modified="2018-09-12" version="1">MMNVFYKKKKLQIVTKATKRFPIARHMYELVFESDQACLEAAAAGPFSHHGKEMVTELPSASPLNHVVQVRFTLPSSSSATPASVLRQSLNDALTLSFGRAGRTQGYTLMQLQRGLAIDPNGDPMAMTEDGFHCAYLRLHADLFQGSTETQKAALNAALPQEIEILGAKYGLRHEFETHYCAVCDRAGHQWGACRKPVSTPATAAPVPGASTSTSTTGFRVAGKNGKHGGPAALNSRASGTNMIQLGPRANPAGAATGNKDDANDDDGGGESVASTEPEGGDTGKETLTRATTGPTKETQTTTVAPVSTPTSPSPSASAPASPLSGGTSESSATSTTSIASTSPRRLRSSSAPGNRRVTRAGSAMILGASGGDGSGGNSSGVNQVKIIRYLKTLRPAPAAILLQEHHLGYNASREGFESAWPGACIRFTPHVLTLIPDGSPLAGHLLSSTPVVFAGAPRFDGRILRSVFRLEELDVEIINMYAPVQEDDRRDFFGLLHFNAPRPKTLRILAGDLNDCPDVSVDRVSITDRAWTPVSHWQTLLSKIAFKALDTVRHVHFCTPAFTRPHYRGRGEERKICSWSRIDYILVQCSWANRLLSASTLFDAPCSDHRPVVATFALPTSNADAEPPLSLPSTSDFISRLNPTVFDDQDFVASIPGVVDEVYRRLEGTAPLGDVYDAALRAVAVAGHARYRSTRADMRRLRAESQSVMEALEARGEHMNEAERDAYAFAKSRLDQLAVKEAQWLRIRAHVPSVDSREGQSASIRTRLNRRSRQTSIVSLEDVDGTETVDMQEALGIASRHAQSLFTPDPARGDPTNARRSLLDPIRAAKCYDDDRSDPTFGRRLPRQARVALDEPFTLLEVEAALKKTDSGRSPGPSGIPYELFKALPTYFAPKLLDLFNSIWEGGKMTASLAEGLVRLLPKNKPGANLKSLGAYRPITLRETTYKVLSKVLVARLNGVLGELLPPAQHGFMPSRRSADAGSHLTLLLEKLKSLGTEVFPEGALLSLDQQSAYDRVDHAWIFDVFEAFGFGERFISLLRALYDPETLGVRYLINGFPTELVRLLCGLGQGDPLSCPVWNITFQPFLDALVRRGIALDLQKVWPGGPRAQLTHLAFADDAVVVVESPAALSKLETLSQTWYEATNGKTNTDKTLVLPLGPNWLRDETVQALPTVQEGESFKWCGYAFFRHGDSKLFWTHVLDRIKAKTRAAGDRTLSPSGKVFYANAHIISTVLHVLSFDIPPQWFIKAAETALTDFVWGGAGRNTVARDFVFQAREDGGLGLISIGDIVHSVALRFWDAVAGSNEAIWAPLARESWRSLVAATRDFSPWGFFSSTARVEKLYRDSTRWGAVVAAARVTVPTIKSELLTLPELLSLPPRLPSLYAEGAKHAYDDADAVAKFAQIADLYWRDEGKGWALVGHRRGFWQHSKEPALQHEHVWSRVGQLLKAKALLPKTALRPARIPLKEAPRPRCFNFFGLTRPFTIRKLRRLVNVVRFPGREDRVKRFRDGTSQSDRKRFWRWLHDRFASAVEQDTHWRLMYNVTPTRKRQHTQGHASSPTCLFCGNDAAVIETVSHYFFECAYSTSFWGGVLRILFDKLGIEDTDVDPSTFTPEQLTMGLPLLRGRGRTTSRWMWVRLACAIGFQRLHLLPWRVHQRFELDKVVAPPSLPSALRAFERDFLSRAGFVPGARDWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MV81</accession>
    <name>A0A2X0MV81_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g02059 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C003g02059</name>
        <name evidence="1" type="ORF">BQ5605_C003G02059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY38676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MV81"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY38676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="43" mass="4942" checksum="5116D4B9EF39A936" modified="2018-09-12" version="1">MVWWKGVSWASRVEQVLCGLDAIRQVACTIGGRKFPCWSRGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MW90</accession>
    <name>A0A2X0MW90_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C003g02489 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C003g02489</name>
        <name evidence="8" type="ORF">BQ5605_C003G02489</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY41259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MW90"/>
    <dbReference type="STRING" id="796604.A0A2X0MW90"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15737">
        <property type="entry name" value="FYVE2_Vac1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021565">
        <property type="entry name" value="Rbsn_Rab-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036531">
        <property type="entry name" value="Rbsn_Rab-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11464">
        <property type="entry name" value="Rbsn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140125">
        <property type="entry name" value="Rabenosyn-5 Rab-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="7">
        <location>
            <begin position="357"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="21"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="721"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="46"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY41259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="750" mass="80131" checksum="36E4FA64E1D8E419" modified="2018-09-12" version="1">MSSPSGSGTTYVPYQSKRNSTASIGSLSGAGGGGVPHRQLGGGAGVFASSSSSSSSFSSSSAPVAASASASASASASPSTSTSASASYLLSSPRPFRPSPIVDTSQQPHPHQHRRMPSSPPPLNSASSGVSSSSAAWPSGPGHSVRGGSGLPGVSGSSGPSVFNTRSASSVSAPTSGLSSRNRSPERPLSANTFRAPSSPLRVQSPSQPPSTTAGGGALRQRVVVQQQQQLHAANGSARAAYQPTYHPTFQAQGVRRDRTEQFVNIRNKRGERNKLDEGRLARRLEKLVALHFPTSTDKEDQNGSLAAPKPFSRATSTFATLSSLRGKSAKEIWTSVAGARGEIERAEQAIVKWQEDAEAKFCPICMAAFGIKTRRHHCRLCGRVVCFLPATPIKPIFVSSDPSLDPTLAIPSAPSTTPIRRERCSTFLTYEQQPFLVGGEKITIGVVVEIEPVETDLSFGAVVPELTGGAPPPPKEKDERKKVRVCRDCLNTVLRQQLKTLPVRTPTWLKLYEVLVQLEQEIEKVLPEFQELALGLQSVFVQFTLTSFEEECSYFIRTNRNSSTRSVLAATSVLDLRKRLLTDLASYDTIAKRIRDLPLLTEAALPGGSQDRLQQAIASRATLFLQGKLGLLRSLGDLDDLDGSKARKVKAKAASSGVKTLAGLLGDAAVKGADRLMSEKVGVGELEVSEKLKVLLEQASARSLNRQEALVRTYVEDANAKRQFEDAASLQMSLTELQEEIRQLRLALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MXQ9</accession>
    <name>A0A2X0MXQ9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C005g03414 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C005g03414</name>
        <name evidence="3" type="ORF">BQ5605_C005G03414</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY75288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MXQ9"/>
    <dbReference type="STRING" id="796604.A0A2X0MXQ9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001069">
        <property type="term" value="F:glycogen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005979">
        <property type="term" value="P:regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2440">
        <property type="entry name" value="Carbohydrate binding type-21 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005036">
        <property type="entry name" value="CBM21_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038175">
        <property type="entry name" value="CBM21_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050782">
        <property type="entry name" value="PP1_regulatory_subunit_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307:SF36">
        <property type="entry name" value="GLYCOGEN-BINDING SUBUNIT 76A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03370">
        <property type="entry name" value="CBM_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51159">
        <property type="entry name" value="CBM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM21" evidence="2">
        <location>
            <begin position="289"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="636"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="803"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="402"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="540"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="716"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="732"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="803"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="823"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY75288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="833" mass="89339" checksum="FCD749CA411A0BE1" modified="2018-09-12" version="1">MPYATPSSLSSSPTSTMTLTTTDRSIAPRPARHHMRSHSSDAIPTSGSGSHKQTSFIYVQPASSEGDKARSASIDATWSLAANAVAGPSNGVPPKPRRIKLFGLTPASAANEDGPSSQDESSSNEAARTDDEQVTPRVENANYTINFTFATSGVPLVPVPSRTTSTPIVSAMRGSGRAKSDFTTRTSAMVRKKSGELVRSSLKGGDPLRRDKPRSAPSTPIGAKYVHFDTQLEHVKHFIAQQRPAAVSRSGSPVETETEDEPEAFPFPAMTSAQAGSISLRLPNFPARFDHDQDAYVESLEMASDGKSIRGIVRVRNLSFEKWVAVRFTLDNWQTVSEVSAEHHESMGSMSDRFVFTIKLQDLLARLEAKTMFIAVRYNVGNREIWDNNGGQNYRVEFVKNPSAPTGPHGTATAHATSGKRQGWTLGHGSHSADPMADLRRELDRLVMDDDLEPTAHHSTRSFTDGSPSMFSSRYDFGNSLKMFGTRPSTHFDGTHFDGFGHPPSASPPKINKAYSTTTIVGGMPATVYYEPASTVSTTYSHAPTSASASSKPSAPLGSPVATRSDLPPDFGSSTLQQYQAASPLYSKVASLYPGPPSGHRVPSPPPEAELARLYSGYKDRPFLPLQDTKMKTAVRTSCHKSPVPSPGAQTPSSMMHYTPLLPPTFRDRSRRSPLASPMNSPYDSPSISPQTMSPSRKASPPLYPDVSPPEEALWSPASSSTDPPSSVNSSDAQSVDSEATSIAGSPLQGTINRPSRPMDFSSFLDRYCFHTGGLNGMPSDSSSDLATTPRRTLLSGCGYYSPAGSSRASSGASTPPREDATYATTFPSAIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N1B6</accession>
    <name>A0A2X0N1B6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C007g04491 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C007g04491</name>
        <name evidence="2" type="ORF">BQ5605_C007G04491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY60833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N1B6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY60833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="585" mass="65970" checksum="8058E0917DCF8956" modified="2018-09-12" version="1">MQPIAKSMYWAILVQRRSPPYQKLVQGGGLVVKAEGESLEWIGLSFDPTGNTELANVNLVARLEAVLDSAQDRGLTHHTRAFYVNRYAIPKILHILSADIPPLEVVKELDRILVDFVRGGKRRSCYGKDVVVFTPRFKGGHGVMRMQDVVDSVAARVWDVLLGGSDAIWQGLARAAIVRAHPAPDFDLATDAWPCDYTPIRTDLHPRWQAVLKVPSTHNAQVKPRTLTLANLLALPIKLHTLHYLPGAPAVSRSPYDADYAAFSNYAKVADLFRRELYPGGGFHLWTPPTDVVVSNSEYDQRGRPQREHIVAWYRHAINRLRFTPIAQPVAAVRINGPPRIRPRSEVRPTTPLESILPHPIDPPQRLPRPALPDQSTQYNLLSMDRPYTIRRVRRVLNAKAFTDTIGFRDSLQPDDIKGFWKGVNSKALTAREREVWFKLVRNFTPTRSLQFHQKHDDSPACLVCGAPKDDREHYFFDCVDSGNVWIAARGVLCDALGLDTIDNTHYTAVQRMFGLPKLKASLRDQEGAGRTIEIFTGLVLEMISSGRWGMQKWGTRMEGVGRRRIILEERLKLRAGGAWGRRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N3B0</accession>
    <name>A0A2X0N3B0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C032g11044</name>
        <name evidence="4" type="ORF">BQ5605_C032G11044</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="FQNC01000067">
        <property type="protein sequence ID" value="SGZ04120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N3B0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="62"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ04120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="241" mass="26183" checksum="01DF474B87CE386A" modified="2018-09-12" version="1">MKNSYEFENSLQHVLFECQPSSCFFTTLKVSETAEGLISYGRHTKCSGRVNCGSPSRGRSSTARFGGVSVVLAGNPKQCLPVIPKSSPAQIVDARIMNADFCGVLSIGSSELETGRRTKQKTVAFPHELLLPATTRNSSGLIRHVYPVPALELDNMSIGEKVEYIRDRAILAPKNSQVDQINDMVLDLLPGDAQTFYSADSDAFVAVNVAAQSPIALRPLPEDQLRPMHPPPVNAAISRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N3B8</accession>
    <name>A0A2X0N3B8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C032g11054 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C032g11054</name>
        <name evidence="1" type="ORF">BQ5605_C032G11054</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000067">
        <property type="protein sequence ID" value="SGZ04271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N3B8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ04271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="521" mass="58074" checksum="733315EBE0A79478" modified="2018-09-12" version="1">MTPWACSSARCWAPRGSTLLFVPLRSTESAPRRVMTTIQPILALRHVYEPAVQLCRTDSVVSAMANSTLGSPHHHLLRKGECAGLESRSNPQAHVSIRDDLGPQTAVCTHCKARHWECERPKSTRHFSACCSQGKVRLPPPPQPNLEYRQLLQGSDSEAVAFRENARSYNNALSFNSLAALWDQTQVGTLGPPVFRVFGRLYHRLGALIPAVNQCPAFAQTWLINPAEATDTRLEPDGADSHMQRSTLTKLESMLRTGNRFMREFASAKARAARKWRCLSAIPTPTREIVDVKTLFSRCTVIDVPRVGPSTRSLARSIRLRCLRYPLLFPAGEDGFHPNIPLCGSTMVSNCARYLPVSVWMTKTNRRTKTATMRMKTARKGTKRMVMANDEGQVKGSRWRVSRSQFFAHYLPKATSTSQSRIAPNVPSWTIPGCDGVRCQTWKASAAHHDDVRPRLTGNQGCTGADKACNRPDLIARVFEAKSGNKRHAGCFGNECKMNGFCFFATVRLSCYFLNFILPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N6H2</accession>
    <name>A0A2X0N6H2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C022g09413 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C022g09413</name>
        <name evidence="3" type="ORF">BQ5605_C022G09413</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0N6H2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1313"/>
            <end position="1598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="695"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="757"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1892"/>
            <end position="1917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="758"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ22014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2136" mass="237560" checksum="D7F09491B2A64E6E" modified="2018-09-12" version="1">MVVTAWIGKKARSFYWIVFCRLPTAQQPALETQPRRDIRRCRERSMQTGDPGSAPGARAPPPPASAPTSLPIAGTKETQATQVAGRTATYAAATNSSVVSNETPAQQQDRLARLQALPGILAAIQAVPGNRADRFVQAIFATPDFPSTVATALKFSALNATRNIINPFANALEVSLSHKSTGRASATDKGELVACVRTLLSPNTPICFDTGVPLSGDLEAFMPRITGLQHSSTFRTGVLHHRITVGFVSAEARDAALASAPMLVWNSANARFAKAHPFHRNMLEMRINVGVVRPPSKEQIVAAFQSIVQQLSTKGHSCQLVQVLRVIHVDTAKAYAHTVGDFSAFIHFDDASLFQHPTTTLKEILPSRMDLPTRGLDVTAVRHDYEKEAPCARCHFAGHVERCPLMQAANRKEAEDLARHAVMRGAGMVGGGEQTGVGRAATTTTNNIRPTANNNNTSEVVAPSRALGTDQLESRNRFAGLEVEGGQEDDIEEEVAGKEGEEKEQVKEGDEDTGAKADDEDSDSDGNAGAGIDKAGGDGKDDDKDDDEDDDKDEQDDSSEGSERRGDDVMKDGAEEEDEGMETEVEEEVEQEQGVQDDSIMIIDDGQTTITTVSRESTPRSPSWPPLSPETLAKSLREGAEWDRANAEAAARVQAENEAIINAQLDAQEPLVRHQFAEWGQEDGQLRFINIRGTGSRSNKKMKRSQTVADLSDPSDDPVDVKRVLNRVKGRAGKEVAGQGKRVTRSMSAAAAMQVEGAKAKAEKGKGVEEEKRWSDHEPEDDILPEFPLFEDNITAKSTWNVRRCMGIPEKRRDIYTYLSTFKASAILLQEHFIKPELWQCIKDEYEGKAFISKHCLTLIPADSPLIDAEILRTHSALDGRILVTSFRLRGDIRILEINNLYAPVDTKQRLTFFDKLHFHRTQSTHLRLLGGDLNDCPLPAIDRRNQGRHGHHWPILIGKLDSPYTDCIRFKHPLTPSFTRPNIVRKRPKSFSRLDYFLLQRTHQKRLVQASTIYDHPKDLSDHRPVSIVLVLSDERGDAAQPNNSLPTTSNQLHRINAATFKTAAFQGMLEGWLEGASGEEPVGELEVVLGNCEKEGRELARREHRERVERMAVLVGRVQDLEALPVMGDEETAEWTRTTEELRRAVNERARQLRIRAHVPEIATEERLSRPVHAKLAARSSDSKITALRLPNGELTHDIDVALDHTQAHFQRLYNLEPRDRDHVERLRDDFLAPIRSARTCDDPSSDPLFLRRLSEAHIELLQQPITEDEVVAAIATTHPGRSPGPSGVPYELYHTAPRAWAKALSRAFNAMTERGSLSPRQGQGLVRLLFKHHKIGADRAELSSYRPITLRECDYKLFTKVYVARLNHVLPDLLPPQQHGFVKGRRSADASFHLRLLIEELGARGTEFPDAALLSLDQSSAYDLVEHEWIFAIFDALGAPATFQRVLRMLYSGDSTTARYIINGFLTPPVRLTCGLGQGDPASSSVWDVVFQPFLDALHRRGIALNLSLPTIHPYPQSRAITSLAFADDVVVAVAGSESLTLLDDLALDWRLATNGRLNTDKTVVLPIGCRWEAGDRPLVVKAEGESLEWIGLSFDPTGNTELANVNLVARLEAVLDSARDRGLTHHTRAFYVNRYAIPKILHILSADIPPLEVVKELDRILVDFVRGGKRRSCYGKDVVFTPRFKGGLGVMRMQDVVDSVAARVWDVLLGGSDAIWQGLARAAIVRAHPAPDFDLATDAWPCDYTPIRTDLHPRWQAVLKVPSTHNAQVKPRTLTLANLLALPIKLHTLHYLPGAPAVSRSPYDADYAAFANYAKVADLFRRELYPGGGFHLWTPPTDVVVSNSEYDQRGRPQREHIVAWYRHAINRLRFTPIAQPVAAVRINGPPRVRPRSEVRPTTPLESILPHPIDPPQRLPRPALPDQSTQYNLLSMDRPYTIRRVRRVLNAKAFTDTIGFRDSLQPDDLKGFWKGVNSKALTAREREVWFKLVRNFTPTRSLQFHQKHDDSPACLVCGAPKDDREHYFFDCVDSGNVWIAARSVLCDALGLDTIDNTHYTAVQRMFGLPKLKASLRDREGAGRTIEIFTGLILEMISSGRWGMQKWGTRMEGVGRRRIILEERLKLRAGGAWGRRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N6P3</accession>
    <name>A0A2X0N6P3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C008g05317 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C008g05317</name>
        <name evidence="2" type="ORF">BQ5605_C008G05317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY80164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N6P3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY80164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="63" mass="6704" checksum="4680830216274EA3" modified="2018-09-12" version="1">MSASSPYGTRSSTWSPDTTAKSESLSPKLCAVAEEDDQDLLYEKLPATQVGLPAGPTRSFMVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N7A3</accession>
    <name>A0A2X0N7A3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C009g05568 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C009g05568</name>
        <name evidence="3" type="ORF">BQ5605_C009G05568</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY82412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N7A3"/>
    <dbReference type="STRING" id="796604.A0A2X0N7A3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF162">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="2">
        <location>
            <begin position="35"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY82412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="401" mass="44140" checksum="95557241F501AD47" modified="2018-09-12" version="1">MSTLSASNGHAAPPPATVQASSSTGGITEDEAALYDRQLRLWGVEAQNRMRQAKVLIVNFRSLAAEIAKNIVLAGVGQVTLLDEQNVHEQDLGANFFLREDDVGQKVSRTLRREAPSGRVGPREPTRDSLVPNPFLPQRIQVGAPRLQALNPRVELLTRTDAALVQDDTFLAQFDLVVLTDCDAPTLQRVNESTRRLGKKLYAASSVGIDGWIFADLLEHEFVVDVIKSLGPGETVNVPTKRTLSYTPFDSILSHSWKKSRARELRKTQSNLWGTLGKFHLNNYFLKHGHAEIRFSEFRLRVALLEYQRTNPGQPITLEGLKSTSQELLPRLGVKTELLPETILSRIASTSAFEFPPSAAILGGIAGQDVLNVLGGKEEPVRNLMVFDGQTGAGHVWNLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N9X9</accession>
    <name>A0A2X0N9X9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C033g11171 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C033g11171</name>
        <name evidence="1" type="ORF">BQ5605_C033G11171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000066">
        <property type="protein sequence ID" value="SGZ01888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N9X9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ01888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="300" mass="33412" checksum="98ECF28E7BDC2BFC" modified="2018-09-12" version="1">MVPRPYVETDFRAIRTTQPLAHRLVISNLPATSDNIAKLTAEVTIEHLLVQAGISVNEHPVFFQSHEVLNLTGLSDPPQSRYKALNTDYFEIIGPKDEIEFTSKIFSFLNNDSMPYYPSSFESELNDEVRWVRLAFDSVKHSGKESYDIIERAPEEAIRKAIKAHLDKHFEDMKNVPAESCISVTNDSGTRGDQCKVLVAVRMASAFMVDKITATKDRSTLSAKVNIPMRPTSRLTPQVTTEPLLVEQTIVGVFKRIVKTRGMREPFAIGVLGAMSSLGMIRAAHQLDGAHSSIPDVSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NAL4</accession>
    <name>A0A2X0NAL4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C031g10959</name>
        <name evidence="11" type="ORF">BQ5605_C031G10959</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="FQNC01000068">
        <property type="protein sequence ID" value="SGZ06656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NAL4"/>
    <dbReference type="STRING" id="796604.A0A2X0NAL4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF888">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="10">
        <location>
            <begin position="151"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="601"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="749"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGZ06656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="771" mass="84702" checksum="3EE3C3FC5FBC343F" modified="2018-09-12" version="1">MSYPWTDDTTYSYRQSHTHSSHHPSSTSHSAGRLSHELVVALVGLVLTSLAIIVTWVALFGRPRSSAVLYFIEGFVGDNWILAMVMKWAGAVDWTRIGSGLAIDPDADDDEHSELLIIIPAWVQAALPLSSGFPNAHLPIASGDPNGTHYPGLLNAAGNLCFLNATLQSIASITPLLDYLESLPSTFNSPNSVILTLRRTLHALNSPCILRPPPLRPTALAHALAASSPTRKRLLASREQQDAHELLGMIREAVEEEVDKIVRDARKNELPGLGALLRFGESADQDKGKGREGVNDAPGKNDPWLLLTSQRVQCLTCAYTRDVRHTSDQQVELQVPDMDRCSLYQLLDEWTKLDLLSDYACRKCCLAATLTKLEEQRDRLALVDSVTTLTASTENCTTTSSGSTSNRIVKSSEAANAFEPLLDSASYSTRTDAVRAAPGVPKMTSSRANRRRKVQKIINQVKEAFDAGDYEKEFGNEVKVEKVFGPAGKLVRFARLKGESVTFVQTPEILTFHLSRSSHYATGGGLAVKNHCRVDFPEYLDVAPFSNDPAFTTNVPPASAEVLLNERPKRDFYRLASVVVHHGTHSYGHYVAFRRKPVLPPHLRQRDQIPTQEEGGRRSRTSHPDPNTNPDHSDAVGAEPNDELDSHLKRFVGGETRAEWYHISDETVQFASIQHVLAGNPFLLFYERVKQDDEDGAGGGAEGWRMQVGKGKGKKVDWKFEGMQLNEGGEGEGEGTRAFGEPRVLRRWELASSSSAASRTEKTGGEEGASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-10-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NCJ5</accession>
    <name>A0A2X0NCJ5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C041g11961 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C041g11961</name>
        <name evidence="2" type="ORF">BQ5605_C041G11961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000119">
        <property type="protein sequence ID" value="SGZ33381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0NCJ5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052208">
        <property type="entry name" value="DmX-like/RAVE_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022033">
        <property type="entry name" value="Rav1p_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950:SF9">
        <property type="entry name" value="RABCONNECTIN-3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950">
        <property type="entry name" value="RABCONNECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12234">
        <property type="entry name" value="Rav1p_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAVE complex protein Rav1 C-terminal" evidence="1">
        <location>
            <begin position="638"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="domain" description="RAVE complex protein Rav1 C-terminal" evidence="1">
        <location>
            <begin position="951"/>
            <end position="1290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ33381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1375" mass="151080" checksum="232A1735739324D9" modified="2018-09-12" version="1">MDEQQDQDRSPSLTLRRVVSGPCNIEAGASAWASACEPHSATHPIPRIIAAVQDRINVLDHRWQLVDSLPFELAFPSQTHLESLVHAVAFDAHSCRIASSSHGRVAVWHKPTARSAWKIHSSFVAPCSVHALDFRRSRIVAAGDSLSLWVLDEGSALPRSASRIVMAKLSPSSDLLATVEQLCCQTLTYEKDNRTQTRFRLQRIPLIAAAHPRLATKRRCFRVSELACDNAIENEPSFALITIGLDDNLRRSEPILFTETIDGVFRIWGCVIDEPDRFSLWASLDVASGLNQRVPLMTKRLRGHLMVHDTTSEARGREFSTTDEFLVVFTDGSAASMLVEVSAELAQSRWEHTGLLRADISRPLQNFNARPPACLVQSAGAISGVAFAAEDLPCLRYAMLLNISDTQCVVVGRNTRGVVVTSGVVSFLDTHSFMGHSRSTKPPVNMVGCVSRLLTTLDGNTTIACGSAKRVQTWTYFLPGHDSKSIIADIQRVSVGHCVAWHAGGKRLRVAVLDTERLRVYDLGPGVRSRLLAEHGVLSAAPFSSFVVAQSGCNAERVSLHALSRDLNLYSWIVEGCNICSASPVPVASKWRTLPRIKFLTSSTNSPGPGVPSEHKIVLFDGKGTLVVLKALLSPAGPVQWLEEAQYSVSQSQPTAAAVSPTGVVALVSPSTPRNPGEPSSFELSFLDERSVDPWSFQRFEAYKNDTRVHLSWSYDGQILAAGSSFRVRLFGAQRIDANGNRSGWGEVASIEVELSLRGQISDMCWSARKLVLSSRDHLCFYDLTLTTGEALLDKVETGSNPLPLSHPQLLHQALLQGRFEAVTSILAGLASHLNEDERVAESVPAAPAELLLHKLFMPDRSKGNLSTRNAATGLLSSLTFRGAATRSACASMLTEEALGRILAAARARALNGLTDSEHEALALVARTTYLVGNRLCLSAFTKDVIDASFHCCYQVQGKQRTLDLNGLRYLVALQSFTLKRETVPRNSDSLDRLANRYVIPAFHSECQTVLVEETGRIIGGTKLNWTTAKALGMFMWIRDRELLTTQMEVVGRTEYMNPNQADKDPITAMLFFLAIGKKSAVTTLWRQASGNADQNTVLKFLSNDFELARWKTAARKNAFALLSKRRFGERSAIAGLAFFLLGDSLKDAVNVCLRQLDDFQLAVAISRAYEGDCGPVLKEVMELTVIPLAMRLHSRWLVSWAFWMMSDRQMAAYALVLPFGDLFQRTSMTYTAPKVASYNDPYLAVLYQQIREPQKVLENSQDVVSESDFVLRMARNLRRMGCHLLALDLVRNYSFAGQSALSPSKLRIATDRAFDAQCLALKGSDHGRPGVANDVQARKLVTGSSSTSEVVTPLPGKTRKIVVAAPEFDMSAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NDH1</accession>
    <name>A0A2X0NDH1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C022g09485 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C022g09485</name>
        <name evidence="7" type="ORF">BQ5605_C022G09485</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NDH1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007273">
        <property type="entry name" value="SCAMP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10687:SF90">
        <property type="entry name" value="SECRETORY CARRIER MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10687">
        <property type="entry name" value="SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN SCAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04144">
        <property type="entry name" value="SCAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGZ22418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="339" mass="37481" checksum="AC028B90DC5AC986" modified="2018-09-12" version="1">MSSNPFADPQHQQGMDSNPFADPTVQQGLHSSAHEYGEDADYEAATTKTSAAATGSAPVDMQSRFQDLERREQELRSREAQLTAKAEHIRKVSWRFWDRRMGSRDGQTGRDGHVACRGISSHEGAGKHAHGRNNWPPGPFPLIYHDINEEIPAEHQSTVLTLYRLWMFLILTLTVNLVAAILLLVSQANNGGADLAAGIMYLPVIGALSFFLWYRPAYNAYMKGSAMFFYMYFLFAGFHLAFSAYMIIGIPSSGSAGIINLISRFATGHLVAGIFCALATACWVLQGLGSLWMYKQVYAHSSGEKGHTFSEAKQEISMYGLKAYLFNSNKVPNQPNQGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NFU2</accession>
    <name>A0A2X0NFU2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BQ5605_C027g10292 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C027g10292</name>
        <name evidence="12" type="ORF">BQ5605_C027G10292</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NFU2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF10">
        <property type="entry name" value="SLC (SOLUTE CARRIER) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="29"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="126"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="227"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGZ28235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="323" mass="34607" checksum="C602886FBDB6889C" modified="2018-09-12" version="1">MSLGHEGAQLSSSLATTASTTTTPTTTTLDPRLDFLAGTVAGVASLLTGQPFDTIKVSLQCQDRSHKTYRNAVHGFFKIVEEEKLKGLFKGVLGVAAINACVFSSYGLAQRHLAPLFDTSTPSSKPSLLVIVLSGSASGLVTSIITTPIERLKILQQSVRGRQPRLVELVNKVGARGLYRGWKATCWRDLGYGPYFGVYEAVIRSRFGRAGPGRGGEGVEEDGREVPGTARVLIAGGLAGIAGWGSTFAMDVVKTRIQASEAYVDQARTVPHPYRTVSSTIRNSYRAEGAKVFFVGLGPTLLRSVPVNMVCFFVFEAVVSAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NRI9</accession>
    <name>A0A2X0NRI9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C014g07536 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C014g07536</name>
        <name evidence="2" type="ORF">BQ5605_C014G07536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY19016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NRI9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY19016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="90" mass="9941" checksum="7EBA569D7CFC70B1" modified="2018-09-12" version="1">MHPSYVMPEDSHGTHQAAEETGTSVGEVIIPFGTVLGVELIGCWSKMRCHFTGIFLCGFGMQRWTSVQHLFGARSTSTGFDAYALWSEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NTR1</accession>
    <name>A0A2X0NTR1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U three protein 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C013g07057</name>
        <name evidence="12" type="synonym">BQ5605_C057g12680</name>
        <name evidence="11" type="ORF">BQ5605_C013G07057</name>
        <name evidence="12" type="ORF">BQ5605_C057G12680</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY14724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000094">
        <property type="protein sequence ID" value="SGZ29397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NTR1"/>
    <dbReference type="STRING" id="796604.A0A2X0NTR1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000378">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012952">
        <property type="entry name" value="BING4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040315">
        <property type="entry name" value="WDR46/Utp7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085">
        <property type="entry name" value="WD-REPEAT PROTEIN BING4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08149">
        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01033">
        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="301"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="BING4 C-terminal" evidence="10">
        <location>
            <begin position="389"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="503"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="583"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="503"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="513"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="530"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="586"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00076453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY14724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGZ29397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="613" mass="68991" checksum="77F7293C075A048E" modified="2018-09-12" version="1">MQGTPHQVGKGKGKQREKETPTSLLSNSRQLPAQDPYVPATQSLKKYVYAHPTMLDKNHLSKGAGKTNKRLGHHLHHLSTSAKVSSIKAHEHDDLLLDRSIQGLIEVENELERTWKVTQDEIVEGSAIGAQGKAFALKLDEFGPYALDYTRNGRHLAIAGRKGHVGTFDWQSGRLHTELHLGETVRAIRWLHDESFFAVAQKKYVYIYDKSGLEVHQLRNHIEVNQMEFLPYHFLLATIGNPGFLKYQDTSTGQLVVEHRTKLGACRTMAQNSHNAFIHLGHQNGSVTLWSPSVSRPQVQVQAHRGPVSSIALDPSTLGYRMVTCGVDGSVKLWDTRKWAVLNEYQFKKTPTSVDFSQRGLLGLGWGNHISVFKDLQKPDQNPRMPPPPYLTHTFPGVAVNETRFCPFEDVLGVGHAQGFTSLLVPGAGEANFDSLEADPYEGKRRRREREVNALLDKVPFDMITLDTEMVGKLDRDVRDKAEKLNKDRPGFVDETYRKKSRVDRLKDRGQMEEDEEGLESEDDEDALDEERREEKKRVKLAKADAKNRGRGRNSTLKKALRKRKRNVIDPITVALKEKLEKQRAANKQAKKNVAASRSAASGSAGALDRFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NXH7</accession>
    <name>A0A2X0NXH7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g01906 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C003g01906</name>
        <name evidence="1" type="ORF">BQ5605_C003G01906</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY37873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NXH7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY37873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="196" mass="21777" checksum="57E96867B7DE1122" modified="2018-09-12" version="1">MTLQWAPVNPKERKAHFDTFSLNREPDKTIRIIAGVLDDCPNVFFWLCAAHEPSPAVYVGIACSSAKARQPYRRARKYQLLRVNTRVYADEAFAARIPLITDASRKSHPLDPLAAFEEASTSCAVDEELLRSTEVFAGAPTSLAFATPTAEGLSDDVRKRLKKSGQSSISGEPVHPGLQPNRYWERFGQMSEQVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NXQ8</accession>
    <name>A0A2X0NXQ8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C014g07670 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C014g07670</name>
        <name evidence="8" type="ORF">BQ5605_C014G07670</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY19523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NXQ8"/>
    <dbReference type="STRING" id="796604.A0A2X0NXQ8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000256">
        <property type="entry name" value="Probable pre-mRNA splicing factor prp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010491">
        <property type="entry name" value="PRP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06424">
        <property type="entry name" value="PRP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PRP1 splicing factor N-terminal" evidence="7">
        <location>
            <begin position="9"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="21"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY19523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="911" mass="101145" checksum="773A9F83FDF99FBA" modified="2018-09-12" version="1">MRLQLKMKAPAAYVAGLGRGASGFTTRSDIGPAREQVTDEAAEDKNAGRGEEIDGDLPDRYQDLENETGLFAGMVYEADDEEADRIYEAVDAQMDERRKKRREAREKEEEEKFRAERPTIQAQFADLKRGLADMTDQEWDSLPEVNNLIGNRIKKPRLEGRSFNVPDSVLVAARDRNAVESALSEEQMEDGTKTSMNALTDFAEIGQAREKMLSIKLEQQAGTDSVSGSTTIDPKGYLTGLQSQVLKTATEIGDIKRARQLLQSLTKTNPKHAPGWVAAAWLENVAGKSVQARKIIAEGCQHCPKNEDVWIAASELNTNDNAKVILANAVQELPQSVRIWMRAVELENDPSAKKRVLRKALEYIPASVKLWKETVKREENPEDARILLARAVEVIPHSQELWLALARLETPDRARQVLNKARKTIPTSHEIWIAAGRLQEQEGNTSQVDAIIANGVTALKKNGAILTREQWLGEAERCESAGSIVTAQAILKATLHLDVEEEDRLERWLEDAQTMTSKGLIGCARAIFAYSLNVFPQKQALWRKAAELEKAHGTRETLLALLNKAVESVPQAEVLWLMAAKESWLGGDVPGARAILGRAFEANPESEGIWLAAAKLEAENGQIEAARELMRRAVERVGTERIWIKSAVFERQHATADSALSTAKAGLAKYDRSAKLYLIHAQLLLAQEPPATNAAREVLATAAKKCPTSVPIWLLASRLEENIGLRIKARALLEKARNLNPKSEEVWLESVKVEERDGSGAAKGMLARALQALPTSGILHSYSVWQEPRATRKSRSVDALKKTNNSPAIIVTVARLFWAERKIEKARDWFSRAATADGDFGDAWAWWWKFERQHGVEANKQITLDQCTQADPHHGQTWQVVLKNPKNAGKSVKELLDLAADAVEEEKSTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P164</accession>
    <name>A0A2X0P164_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C002g01119 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C002g01119</name>
        <name evidence="6" type="ORF">BQ5605_C002G01119</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY30120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P164"/>
    <dbReference type="STRING" id="796604.A0A2X0P164"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21032">
        <property type="entry name" value="PROPPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="250"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="391"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="460"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="460"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="476"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY30120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="512" mass="53774" checksum="21C53023A228A534" modified="2018-09-12" version="1">MNLAAHLISDEKRSPILGLQLNCTGTSFATATDQGWAVYRTHPLQSTKFANGSLRLVFPLELSNILFLVGGPPSPLYPPNKVMVWDDHLGQAVCELEFGEEVKGLAARRDRLVVVLKKRVVLFVLGKGGLGIWREGVYDTTNNPKGLVALGTETGSTLLAFPGRQPGQVQIVNLPPLTAPHEMSPLPPAPSHDPTSAPYPSVSIILAHTTSLAALSCTPSGGLLATASSKGTLIRVWDTSHARLVKELRRGSDEAQVFGIAIRTDGEAVAVSSDKGTVHVWDLKMTKEEYQKKRSASASSMGEVTESKQFSMLKPYLPKYFSSEWSHSQFRLPPPAPTASRLPFSLSSSTAAAAGASALSSGVGSVSTAPPTIEDDVCICAWIKVETEVPVGPADASGSSTAGRSDSSSRSNTSATTMGKGSARSIPSHSGEKRIEHQLVALTHSGRWFRISLLGGGGGGGGGGGGGGGGGAEGGTGERLKGVKDDAFGLGRDSTTDCRLEEYRQFGKQDGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P1X0</accession>
    <name>A0A2X0P1X0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C002g01489 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C002g01489</name>
        <name evidence="3" type="ORF">BQ5605_C002G01489</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OsmC/Ohr family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY33377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P1X0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019953">
        <property type="entry name" value="OHR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03561">
        <property type="entry name" value="organ_hyd_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33797">
        <property type="entry name" value="ORGANIC HYDROPEROXIDE RESISTANCE PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33797:SF2">
        <property type="entry name" value="ORGANIC HYDROPEROXIDE RESISTANCE PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="OsmC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY33377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="185" mass="19554" checksum="A230CF00521F2041" modified="2018-09-12" version="1">MFALGRIASLAATSSTRRAPAAIRSLSTLHPTLYTSTTTSTGSRAQGHVSTPEKNLDLTMGMPKELGGSKGPAGGESNPEQLFGAAYSTCFLSALGATHGSLFPQHKPLPKSTTVRALVSIGKDKTEKLPGFLLAVELEVPKKPLQQVGLEEAEIHKLVQQAHQLCPYSRAVQGNIEVVVRVVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P3D0</accession>
    <name>A0A2X0P3D0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">DNA-directed RNA polymerase III subunit RPC3</fullName>
            <shortName evidence="9">RNA polymerase III subunit C3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C003g02120</name>
        <name evidence="13" type="ORF">BQ5605_C003G02120</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8 9">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY38996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P3D0"/>
    <dbReference type="STRING" id="796604.A0A2X0P3D0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055207">
        <property type="entry name" value="POLR3C_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013197">
        <property type="entry name" value="RNA_pol_III_RPC82-rel_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008806">
        <property type="entry name" value="RNA_pol_III_Rpc82_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039748">
        <property type="entry name" value="RPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08221">
        <property type="entry name" value="HTH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05645">
        <property type="entry name" value="RNA_pol_Rpc82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22536">
        <property type="entry name" value="WHD_POLR3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase III subunit RPC82-related helix-turn-helix" evidence="11">
        <location>
            <begin position="8"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase III Rpc82 C -terminal" evidence="10">
        <location>
            <begin position="219"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase III subunit RPC3 winged-helix" evidence="12">
        <location>
            <begin position="457"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGY38996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="619" mass="70773" checksum="201018347DFAB550" modified="2018-09-12" version="1">MGQDRIRLLTHIVYQHFGPVVGEIASILLARGSLTFAHLTRLSSLPPALIHRALLVLSLHMLLYHSEIDSEKRVEAFEINQANLEQRLRGGLYIDLANRKAQSWSPSPSSPSSESTLSKIIQEIWKNGMMGTHDLITFAKQDTLLRHRMLVIQHELAAECSVDPSSSSSKLLKGKGKARVLGPLSDAEAQARAQVLCKRAFHDGYLALITPESQEMPRSLEIKWDTEARQGMKSILSAKETKEVKEKIQARNDTHHEEQKARSKNMTLDELQDSYRVRKKTKPYHENDLDDLESVEGMKELPNGATFRVNAERLHTVWRSEMMERFASEIYNPHIGRVFRLVLDVADASIHSMEDQESRPINRNELSKAWSSLPRSERVTLRHAFNDDPCLDPKWGSLHKKEDADLIVEILYILAKVDDLGVNAASGFLRQAGGDGPNARWSVRYKDLGDRMKRALVEAMVEDKLDKKAIKCWRILDAKGKLDEKHLARLAFLTVKEARETIARLRAMSFIESQEVPRSADRAPSRTFYLWYVDYPKVVRTLLDHQYKALANLQVQKTQLMERSSKVLEKSERTDVREDPKLMDSRDKQLLDDLDKLMEALIVAEMRIDCQVFVLKDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P4K4</accession>
    <name>A0A2X0P4K4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g02382 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">BQ5605_C003g02411 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C003g02411</name>
        <name evidence="2" type="synonym">BQ5605_C003g02382</name>
        <name evidence="2" type="ORF">BQ5605_C003G02382</name>
        <name evidence="3" type="ORF">BQ5605_C003G02411</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY40469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY40700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P4K4"/>
    <dbReference type="STRING" id="796604.A0A2X0P4K4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY40469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY40700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="246" mass="27291" checksum="0A14860BDFA03B2D" modified="2018-09-12" version="1">MTTMQPILALRHVYEPAVQLCRTDSVVSAMANSTLGSPHHHLRKGECAGLESRSNPSSPTFSQGKLLQGSDSDAKAFRENARSYNNALSFTSLAAHWDQTQVGTLGPPVFRVFGRLYHRLGALIPAVNQRPAFAQTWLIDPAEATDTRLQGPDSAETRIQRSTLTKLESMLRTGNRFVREFASAKPRAGWDTAKEWILRLCLPPSRDRRTHNPPTSSTEMAMLICDSDTNTRDRGPQDLILQVHGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P5K0</accession>
    <name>A0A2X0P5K0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C005g03233 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C005g03233</name>
        <name evidence="6" type="ORF">BQ5605_C005G03233</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY72930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0P5K0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019783">
        <property type="term" value="F:ubiquitin-like protein peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="5">
        <location>
            <begin position="154"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1425"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1686"/>
            <end position="1713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="415"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1426"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1436"/>
            <end position="1446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY72930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1713" mass="191252" checksum="16A726BD958506DA" modified="2018-09-12" version="1">MYLDDPDIELLDDDFERMAPLLDVRVSELLTFRFDNPETQIQLSWSTDEPLEFDTLPRPLRAWRDKFKDREAITAARKQGYRSIAITGHRLPFGVERIWRHIDYAERMRSVVINSQEWMKSYLGVDIENQPLIVKALEVLPSLLVEDQYTPSMILGCSASLRTLLDFVGSTWLGETAMDVAITSVLASSRVQASTAPDKVYGAFPSDLMAILVASRKHQSDSPQREVLDKYIFASPLVPYRTLADLRSFVRARPQSVWFLPLCFRDHWAMARVDVGQRTWTLFNSLSHIRIDEITRNSALALFDYLELHILNTEPKQGRMAQQADGSSCGPAAINVVETELLLVAPFSAGCAHIARIRQFHRLATFATKSQHLTHDFPAPIAGIDRNELDVEEMAEIDNDEQTWSGICFCSDSETDDDCTTDDDCTTDDETPKSGESITARRVRLAKEHLKDVEYSKRHGVTRFMKHLNKKPPCTNMRKIDHYFAVRSPAETAVQSQGKSLADPPACPGLTGKRVEMYLSKSSARGGGAPSRLKLIKRRFPRIGKRVLTRSERREINNLEANEWTWVNDHSAPRVNSVNCTRIGMESQCGTKLESCAKCKALLRTKAFSQALHRPRAVGPTIKFTNKRLASVEALMSKVFKEHQGLEELLGTKDGKVYLRFAQGLVSGELAGANILKGMAKVAVIKHRRDAQGKDMRGYVRDEALLDFEHALALASPTALRVVQKTVGGVSMRTLQQVSDLSYPSFLQATDDSKPLRQHRATFEKPRFGLDEPHMQRIIQKILSDGKTFNLHVDDTKVRQVTRTTRVYLKDKEAEARLRGQKIFRHELVGMVGPPIVYETTQELEGIFRGPNPPIAGTKVRVYMLAPNDVSCPAQYLAAFVIGDSTSSSEAADELESVIQFLVNAGLGHLLASISADGAASEGVLQRVMAERLGGDEGYTGEGNRRRELAHVIPSPGPDKVFPAIRLASVQVGNTPTCFNRDEKHLSKNLRSACDSGARAIYGGTGCIGYRDLLTLLNVEESARTLYLRDVIGRDRQDDNATHRAFSEATLALACRLYEDGKFDADAIVFLFLCGELHDAIQNRSLQPIERIKMLLTVRYTFEGWLTFVRNRPGYNVQSFIAKETLDGMRKVVDANIALIRNYRDFWPEEAFIPWRHGTEMVEHFFGGLRKVVQEFDALEFLQVSHPPFMASRELLLRPTETADSRQGYHHMYDRLDDLDLVAMRTYPSDEEIRSTSLVSAGLAKEILLGLRMWDTIQYQKSNQLEEDIPVNAGEPWHFEPEDAEPFSYLADLDRTLDGIRTKTCQGLVVLDPKERKSVENAVRSLAALGLDNDAALLAVQQAYDEADAQAEERFLLDAIVTANESLPATLNGTSILSQAQIIRLPSLLRHDSRQLALDLKSLIQHRRAHQCAHLRAVLLKGRHGATTSTAQDSDPTSKAKLSEHGEVHSSVLRGLVQSMGAARLEAVSGVARSIRWTGQGTFSRFSTANETDNIGYIEDGRKEVRMQLRARQYTVFAKIPMFGSIDGNVTSATPLKIGSLVCFGLKRSITPVSCDASNIGEEQLSIGLVRYMYAKATSNHCDRAETDSLALLSNVVLQELRVVSKGRYSTHMIDGKTRFFGLDARQIIQSLESSSMPALTLAPLDSVAYLGERVFDLSQQAEARFCFLRRCNGLRDASVSLSNQMKGVKDVGSKRKAASAGEEPSAKQNRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P7W6</accession>
    <name>A0A2X0P7W6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C008g05164 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C008g05164</name>
        <name evidence="1" type="ORF">BQ5605_C008G05164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P7W6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY79564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="319" mass="36133" checksum="999E2AC05D123E50" modified="2018-09-12" version="1">MSPATRIDHLPVELLRVILSTLRDSGAYQSSLKQGSLVNSRWRAVAQPLLMQDIHIDSGVAARRLIKSGMLERHRHCTVRSFRLGSLNGCKTWVNYIRIILIEMMHSLSHLELVGIHGIDPGWFESASFQSLRSLRLSSCTFDGELESSTGRLPPAVDLPNLESLTVEQENDWAYVLPPCKAPRLESLALIHTRPNAFSKDEVLDRESDVALIQTMPELIVIKLVLDYRWHLTKLSIEIDLAICIIEPIIATITRHCEHLKDLHLHLHDSLFAPHSRVRFHKELLQRIVATIHQSKLQLETLCLTGWDEGSLPSISINT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P8T1</accession>
    <name>A0A2X0P8T1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g04181 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g04181</name>
        <name evidence="2" type="ORF">BQ5605_C006G04181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY56853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P8T1"/>
    <dbReference type="STRING" id="796604.A0A2X0P8T1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY56853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1246" mass="138515" checksum="555E8FD33B148845" modified="2018-09-12" version="1">MELTQVAHTDKRPRTDEDMDIDKAPKSTCPTLSPVFEQHWTHFDNFGGGGSDFNDPHSDDEIGGGDRSRFGRTAEEVTIPELVPPAAGEQSAPEEWKEDGLEPEAELTREEAAALRWSEPDEDFDEGLAGLASGQGCAADRRTEADLGTPVAGSPPQRSVMPLAAVPSEVYPLDRRTPVYGGERSEVGEDTPVRQTTLALAVWARSHNVSEAEFEAIASIIHGPSFSREQVPASLKTVLSRIERRLPLPQIKSHLVPVELKKTTYNLKARKEDAPAFTIPLIEILRTQIVGDSSLWEKYHFGFGQQSTHQIRENCWDGESWNESLVANRSEYPIFSKDGTTRLYPGVFVQYPRSSSRYLVKDAKAWGQIRSIWRDVTAGGGGGLVLHIMPLVNEFEASNAFKKMVNYSMGRGGRTWSQYTLDQRLILSPRRRIAIVDGHDTVRISDVEARVNNLDILRRFTVEDSPAGLHEEVASTPPDRFFVDTALVHGVGRHERADPAFTWSTKIPLTIAEQEVLNDDINPEILPAVEERPREVRVATRTVVLSLFHDNFAVFRQSAHSVGGWYAIVASSPPNCTRFVEYKVALRLHAAWCVCGDLRDVANPTLRELAYLARTGIEMEAPDGHKWVIFVKVINARADMPEAAEQAGVLTPTANISCRHCTTPRDHLVLPPLDPVTLFIQQRTLDETNACRSFSHSLPTKAERGAYLSSKGLKDTPDMYTSAGLTFDPHTQLPPDPYHLVTGVATTFLTHVIKKMLSDKGRSALSRSRTLDPPLRLTVPSFLGSLLDPSYIELFTMRQRLLLMSIFPFLLAIALESEHHNGLSETTINLMKARKLKGGGKSIMSPREILRNLINTSKRLARLTQLCFGPTATRETDNEIDDIARSLPSQIVQVIAPFDSRASENGTVANIARLPNLHALRHLTSSSRAFRTIQILSVAIDEEMHRLSKAKVATGNRREVTKAFAIYSVVRGSLASAERGLGSPVMTKGLKQLRKELPTLMSWLDAPDDEDQLEMKEASEDTTAPNGVKRGTLAVGVERLFARVHLIKEIKGDGCRRLGYSTELSRGPDGPAGAPSGIKTISIASLRDAYAADYEIGADRLHRLDWYSPAGRVRFWKRFRYDDRVLERLVTIQVGDLIQVAAPEGSTTNFAFARVRAIFSNELDSSGERYLFMDIEWMKVGSKKSLPLLGQVETVELQKRANAATAMSFPKIIGLFKIAHVLAPHVMTDFMTKDIHVVNAYMYRMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PAM8</accession>
    <name>A0A2X0PAM8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C036g11556 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C036g11556</name>
        <name evidence="5" type="ORF">BQ5605_C036G11556</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000063">
        <property type="protein sequence ID" value="SGY96283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="898"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="392"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1157"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1173"/>
            <end position="1183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY96283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1803" mass="198816" checksum="7735E391ABEF195C" modified="2018-09-12" version="1">MTTPRGFNFPSDKVLRLRRSIYGLKQAGRIWNRHIDTSLRNLGYKATGTDHCIYSRIDDQQRPHYIALYVDDLLIVSPHLDEIERVICGLEQRYGVKRLGPAEYILGIQIRRLDDGSIALSQERYIMDVLARFHFDTTTRGTTVPMTPGLSLTAIPGQGTERIRSWYLQAIGSLLYISLGTRPDIAFAVSYLSRFANNPGRRHWIAVKHVLRYLRATYRDELLYARGPAKVTGVVGYSDVNWGACVDTSISTMGYVFYLAGAAVSWSSKRQTRVADSTTDAEYLALSHAGKEAIYLTQLLSELHVSPIAAAHIFTDNEAAAAVAHDPVRTSGTRHIRLREHFVRDMVNRGDIYLSHVGTADMVADVFTKALGPKIFGTHCFALGLRTRHPRLKSTSRSRGGGSGRPGPGLRRTERGWDLGARGEPGPLAQPRGSLAVDLARVALLLVDRIELIEYLCEPFVDGEALDPWLANFNRLFEDLVAAHVSRDKAYQRARIDGTSFTQSDFDKWVPPPALSKGVRMDLLKARMPRNLVTVIDSIGTLPLLEQVEGAIRRAALSSSRQIEPIAEALAARVQSRSQPASGRPCLKPSGSPFGTSAPPFLQASRVPGLKERWPHGISHAGRLKLGRMQCRRCYEQGHLGDECTVPSAEVSRRCIAVLAKHNITIGAADVMALVAVDRAPEAQLEDEAYKGYFVVGVPIGDDDTALYLSDIPRYLLDSGAARHMTTCRDLLIDFKPFTTEHIRVVGAFNSSAMATGTGTLRFGVDEVSIELHDVLLVPGLSAELVSLAGLMKDGYELSNECDTAGKHTGIAISSATSRLSFALDRNHYVLQASSHPPPRADHLALTATTLPTDIVLWHQRLGHPSWGRLLELVRSGQIPLNVAAVTPDQIRLLDHHPADAPFSRVFADVWGPSPVPALSGARYLCGITDEFLRFRWARSIRLKSDLAAVLQDFIAMSKTRYGGQGVTTLHMDRGGKFVNHRLRDWLAARGIFHELSTAYEHGQMGVQERSWQTIFNSCTPDSVLHKPSDPVTDTRRPRLNRVKTWGCAAHVPLAPKQRPNKLAPQSRLCYFVGYSSQSKAWHFFDPVRNKVFESSQARFFEDRFFPATVSPAMPAIPVAVGLSYPPATLGIGSAAAPPVAKAPAVAPAAAAPPPIPPALAFSNPGPANAPPDGDRSTRTRRPPDYLGFAHAAQHWEFADHAAIQFNDFNEGDPDTQMYSFEEVSALLAKIDSDDTPSVQVALAGPFRDYWLAAMSVQEGALAAKNVFSKPVRPPPGAIVIGSMWVLLVKRNAEGQIVKYKAQLVARGDMQRDRGVHINSFSPTGRAASHRLLLALAVKNKWETCQFDVSSAYLNGNLGGTEIYMRLPGGDIVRLQRALYGLVQAGCKWYKVFTEWILSIGFTRTDSDHAVFVRKEGDRRSFLSIHVNNGLLTGDGDLDGVLCQLKAWFEARSTDEASFFLGQSIRREGKTGAAIVNQGHFVDAILEEHHMANASPRPTPLAAPSTLRNCADSGFDPALIPYRAIVGKLLYLSGTTRPDIAFAVSKAARFCNDFTAEHWEALKHILRYLVGTRNFGIRYQKSFQPMSAILEGFVDADHGADPVTRQSVSGYVFMCAGGAISWIAKRQTLVTLSSTEAEYVAMSYAAREGIWLRRLLADLGFEQTAPTRLRGDNQSAITLAKHPAFHARTKHIGIHFNWKTKESLAELRIELSHTGGGSTTHWEPWRADWCGLVHGHIDFYYFHFIRDHIAEGTIKMVWVPTGTMAADVLTKGLGTQKHYQFVHAMGLIDSSREGASWRVVNED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PBA7</accession>
    <name>A0A2X0PBA7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">sterol 22-desaturase</fullName>
            <ecNumber evidence="6">1.14.19.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C004g02845</name>
        <name evidence="9" type="ORF">BQ5605_C004G02845</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.41" evidence="6"/>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY68068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PBA7"/>
    <dbReference type="STRING" id="796604.A0A2X0PBA7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000249">
        <property type="term" value="F:C-22 sterol desaturase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11082">
        <property type="entry name" value="CYP61_CYP710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000021">
        <property type="entry name" value="Cytochrome P450 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF228">
        <property type="entry name" value="C-22 STEROL DESATURASE ERG5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY68068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="547" mass="61927" checksum="3BD5D11CF40DA2B5" modified="2018-09-12" version="1">MPSMQSSAYITEPTPSSLPSFSSFSSPFSFSLFSSGSTTTSFWSTTIVLIVSLLVAEQTWWRYRKGALPGHKWQIPLIGQFAESLHPSMEAYMRSWAKPLASVSVFNIFIVIASTTDYSRKILNASSYTEPCLVRSAKQILLPENWVFLNGKVHNEYRKGLNVLFTSQALAIYLKVQDRIYRSFFKEWLADPDPKPKPYTFLFRDLNMETSLRVFCGDYIAQENVREITDKYWLITKALELVNFPFAFPGTKVYNACRARASTLKYLAAAARQSKEAMMAGKEADCLLDAWVEQILATKEYQDNKEGGAERPNLLVKEYSDHEMSLVLLSFIFASQGTSSGPCSSGFVYDAMSSSLTFGFQHLADYPAVFAKVREEQERIRAGDHESAVTLEQLEQMPYTNAVVREVLRHRPPVLMVPYLTKKAFPITEDYTVPKGTMLIPSFWNSLHDPSIYPDPDEFIPERWMPGGANFETTDSKTWLVFGAGAHRCIAQNYVFMHMTACLGTAALLMDWEHEKTAESDEIQIIATIFPKDGTRLKFRPRTPTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PE76</accession>
    <name>A0A2X0PE76_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C008g05068 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C008g05068</name>
        <name evidence="8" type="ORF">BQ5605_C008G05068</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PE76"/>
    <dbReference type="STRING" id="796604.A0A2X0PE76"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016527">
        <property type="entry name" value="ORC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032705">
        <property type="entry name" value="ORC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12087">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12087:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14629">
        <property type="entry name" value="ORC4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 4 C-terminal" evidence="7">
        <location>
            <begin position="666"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="162"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="302"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY79186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="903" mass="101332" checksum="861C0010F8BA19C3" modified="2018-09-12" version="1">MVSARIQSRQRRQTNTSSDEDGPSLMTAPSSPPKRRHSSTTLSQSLVGRRGARSRKTEPATAHESKIHDFETTPDRPVQSVKVNYSKGGRRNSGRLGECDEARLDASKPSHLRTPASSVTRTPTKSRIKSSDTSRNQDSMMIDGDDSGLSTPSRTARRSARQVTTSAAAAQALYTPQTTSKRSKNAITDTPSKRSKRSSNDSALIETPSKRNRAKPVNDDESEESDPENIAQDFLQDQPRQLATPRSTPTKHPRVNKSLPTRPIRRARAASVDTAEEETDAEEREGNEDEDEDEEADEQRQRSSIPSRSKNQTPAETTPRRSARARRLPVAKLDIDAAPKELRNRLVGWHMDDGDEDSSADELDVLPSPSRGGKLSTAVTEMATTETVAPIRDLLDHSRLYPARNLSFLFSRILNGLNGWTLPRQPRAPAQFDRRDARAYPYLSGGYSQWEKPLRYAMNGVVQHNVGNCLIMLGPRGVGKTMVSAFTNMLGHQAPRGMTDLLNRRLHQLFERTVQVLEKAHGKDALIIVRLSGLVHTTDRLALRSIAHQLQSQGLSDEDGDFGSNAATMTTLLRMLEPANDPRSVAEKPIIILVDEFDLFAQHPRQSFLYSLLDIVQGNRRKAGMGVVGLSARSDCLSILEKRVRSRCQSQVHQMVLQSDFDSYTELAKQVLSVDATAFHEFGDEHCLGPMADDWNLEVEIVSIKAFLDDPLVLDHLERVWSIHGNTPAPLLHALAPVLTHCENLVKDDDQMLRLPHLSHCMFIAGAKPTFREDLPLDHLTILDLTVCVAAKHMRAKHENAINVELLYRCYLEHVQRNRLMVSAKAWTRLAFCMSFDRLRALEILLPWTGKTTQRPSPSRGDRFKLYRFVPWDSTLDEAVRIRQERSRDVPEPLRKWLKSQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PG99</accession>
    <name>A0A2X0PG99_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C037g11639 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C037g11639</name>
        <name evidence="6" type="ORF">BQ5605_C037G11639</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000062">
        <property type="protein sequence ID" value="SGY94251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PG99"/>
    <dbReference type="STRING" id="796604.A0A2X0PG99"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_bL12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_bL12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_bL12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_bL12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_bL12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL12M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="ClpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="Ribosomal protein L7/12, oligomerisation (N-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein bL12 oligomerization" evidence="5">
        <location>
            <begin position="61"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein bL12 C-terminal" evidence="4">
        <location>
            <begin position="125"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY94251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="193" mass="20109" checksum="87A16907A832C43D" modified="2018-09-12" version="1">MAARVVLSQTLARVAPASTRTLAPRWSAARSFCSSSSSRAEATSTAASSTPPPPPSNLSPKISQIVDQISTLTLLEAADLVDALKTRLNITDVAMPTMAAPSASAAAAPVAEEAAAAAPKEKTVFNVTLKAIDAAQKAKAIREVKALMPNMNLVEAKKFVESLPKVLKENATKEEGEKLQALFKAIGAEATLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PH05</accession>
    <name>A0A2X0PH05_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C034g11307 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C034g11307</name>
        <name evidence="2" type="ORF">BQ5605_C034G11307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000065">
        <property type="protein sequence ID" value="SGY99830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PH05"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY99830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="58" mass="6552" checksum="7712D5831FB895C7" modified="2018-09-12" version="1">MITKNLSQTFYLARRPGLPWAPLRSRARSEAGDDPSQDQRRAVPKSATVVHTCNKWEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PHJ3</accession>
    <name>A0A2X0PHJ3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C032g11048 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C032g11048</name>
        <name evidence="1" type="ORF">BQ5605_C032G11048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000067">
        <property type="protein sequence ID" value="SGZ04179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PHJ3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ04179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="54" mass="6167" checksum="F94E3B3475E68193" modified="2018-09-12" version="1">MFRPPSSQRQFTSRSMRGAIEPSRYCTLPPLAPPALKYHVRNNNQVKDGTTIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PIB7</accession>
    <name>A0A2X0PIB7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C030g10825 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C030g10825</name>
        <name evidence="2" type="ORF">BQ5605_C030G10825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000069">
        <property type="protein sequence ID" value="SGZ08925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PIB7"/>
    <dbReference type="STRING" id="796604.A0A2X0PIB7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012535">
        <property type="entry name" value="Cell_div_Cdc14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34065">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34065:SF1">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08045">
        <property type="entry name" value="CDC14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ08925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="464" mass="50874" checksum="1535D9381F798D7B" modified="2018-09-12" version="1">MDPDELTHHIDALLCITSNSADHASALMALEVGLAGFVVGSENEEGEEEESVRQRVRNRPKTPTPTTRLDAFLRLQDRFEYNITTVLLHWLGSSIVIMTQPRIDQLGPSCEQNMHVGALAEPDGCRCTDADLLRSNLIRCLALLQGLLLMHRPSRALFVRRSALQSLLAVLDLSRPSHVSSPLLSHPPASPSPIHFPSPSTSHHPTIPRTPHNPPSSLSTSPPNRTTPHSNGPNPTNDPSQLSLAALEALLCALVDRPENMRTFEQVGGLATIVRLLKDKTVGQSVRIKVIELLYYFLLPEQEPHTLNFSRPSSSTSTSEFDPNSRSHTPPPITSTPPTKSPSKQTFVLPREERLAHASRGFVPQTPVKVRRFRNGNGSGSDEDGGDSSPLDAEDGEDDRTPRRPNGKTNGNGRTIRSGKEVVSVGKRVTRTTKEKKEMLRKVMPNVDALEERFRAMGLGLGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PJC1</accession>
    <name>A0A2X0PJC1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C029g10719 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C029g10719</name>
        <name evidence="3" type="ORF">BQ5605_C029G10719</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ16008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="536"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1133"/>
            <end position="1159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ16008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1342" mass="150306" checksum="6482BAB6ACF2429C" modified="2018-09-12" version="1">MIHGASGGDDSGGNSSGGYRSESLTVLTFNVRSIKNAVNQVKIIRYLKTLRPAPAAILLQEHHLSYNALRERFETGRLLSSTPVVFAEAPQFDGRILRSVFRLEELDIEIINMYAPVKGEERRDFYGLLHFTAPGPKTLRILAGDLNDCPDVSVDRVAITDRAWTPVSHWQTLRSKIAFNPLDTIRQLHPITPAFTRPHYLGRGDKREICSWSRIDDILVQRSWANRLLSASTLFDAPCSDHRPVVATFALPTSNAADAEPPPALPTTSEFISRLNPTVFNNQDFVDSIPGVVDEVYRRLEGTAPLGDVYDAALRAVAAAGHARYRSTRADMRRLRAENQSVMEALEARGEHMNEAERDAYALAKSQLDQLAVKEAQWLRIRAHVPSVDSREGQSASIRTRLNRRSRQTSIVSLEDVDGTETVDMQEALGIASRHAQSLFTPDPARGDPTNARRSLLDPIRAAKCYDDDRSDPTFGRRLPLQARVALDEPFNLSEVKAALKKTDSGRSPGPSGIPYELFKALPTYFAPKLLDLFNSIWEGGKMTASLAEGLVRLLPKNKPGANLKSLGAYRPITLRETTYKVLSKVLVARLNGVLGELLPPAQHGFMPSRRSADAGSHLTLLLEKLRSLGTDVFPEGALLSLDQQSTYDRVDHAWIFDVFEAFGFGERFISLLRALYDPETLGVRYLVNGFPTDLVRLLCGLGQGDPLLCPVWNITFQPFLDALVRRGIALDLQKVWPGGPRAQLTHLAFADDAVVVVESPAALSKLETLSQTWYEATNGKTNTDKTLVLPLGPNWLRDETAQALPTVQEGESFKWCGYAFFRHGDSKLFWTHVLDRIKAKARAARDRTLSPSGRVFYANAHITSTVLHVLSFDIPPQWFIQAAETALTDFVWGGPRRNTVAREFVFQTREDGGLGLISIGDIVHSVALRFWDAVAGSDEAIWAPLAHESWRSLVATTRDFSPWGFFSSTARVEKLYRDSTRWGAVVAAARVTLPTIKSELLTLPELLSLPPRLPSLYAEGAKHAYDDADAVAKFAQIADLYWRDEGKGWALVGHRRGFWQHSKEPALRHEHVWARVGQKLKAKALLPKTAVRPARIPLKEDPHPRCFNFFGLTRPFTIRKLRRLVNKVRFPGKDGQDRALPGGQPQEPRVRRFPEGTSQSGRQRFWSWLHDRFASAAEQDTHWRLMYDVTPTRKKQHVQGHASSPSCLFCGNDAAVIETVSHYFFGCAYSASYWSGVLRILFDKLGIEDTDVDPSTFTQEQLTMGLPLLRGRGRTTSKWMWVRLACAIGFQRLHLLRWHVHQRFEKDRIVAPPSIPSALRAFNRDYLSRAGFVPGARDWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PK61</accession>
    <name>A0A2X0PK61_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C021g09406 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">BQ5605_C042g12000 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C021g09406</name>
        <name evidence="2" type="synonym">BQ5605_C042g12000</name>
        <name evidence="1" type="ORF">BQ5605_C021G09406</name>
        <name evidence="2" type="ORF">BQ5605_C042G12000</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000083">
        <property type="protein sequence ID" value="SGZ21705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000116">
        <property type="protein sequence ID" value="SGZ31788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PK61"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ21705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ31788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="108" mass="12288" checksum="A2E03AAFCDA85CE6" modified="2018-09-12" version="1">MVRSFALVKIYGMAREGRSLVSGQYPRVKARLVSLYWIAFLSAPTAQQPALEIQPREDIRRCRGDDVHQRFELDKVVAPPSLPSALRAFERDFLSRAGFVPGARDWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PMT2</accession>
    <name>A0A2X0PMT2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C026g10132 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C026g10132</name>
        <name evidence="2" type="ORF">BQ5605_C026G10132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ27579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PMT2"/>
    <dbReference type="STRING" id="796604.A0A2X0PMT2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1108"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1128"/>
            <end position="1145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ27579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1264" mass="142760" checksum="80C6177D29634E6E" modified="2018-09-12" version="1">MPPSSSISGGGSTQFRCRCFLHACDCRPRTNLLRSHPLMLSLRCFIRALDSDMSDKQYLHLIQEASVQKGVDPRRCMSMREMAEFVQTASQLEAEWFDICIEGHVAFVGPHADQEVCGTLHKRVDTDPETKKKKMITERCTEPRFKTIRTRRGNLQRRPRKQAVFLDPVPRIKAMYGCQQQAKMLRSLHEEMRRFISLRKARGDPHAGGYSDVSSGQALARAFEAGVFNDERNGFFGLSTDGALVKENREGSFCIWTVTLYNIPIESGRYRRDSTYVLVIAPCATTTTDFDSFAFIILKRFEEAARGIWIFDSIDHTWFLWGGYILFFLADLMGQAKQSGFAMSRGTFPCDNCEMPSATKPNGAGHYMVEDGQATYRRDRCVGRKKAAEEDTGEDDGGDKSDEDGDDDDGDGDGDERPRKRRKAVPPSTARKQVNAHRAIRGYYPYNGAPRPRPRTLARYKAQISKAFNPTLSERAIKKVRTQFGISAIPLAAKSTLFDVPGSFPIDIAHLLGNNIPALLWKSPVCWRSVKDGTRILSTAVALLEGAQVTTPSAFGTYLRNPQEKANTCYKIHEWLQFELNGSVAVLRDAGMPDKYVAHWADFVRLVRLVLDRSPASIERIQIIDELADRFVQEQERLYVGFSGNRVEAMPLAIHKLHHLGEWIKRVGNLSLVSQLQLERVIGYCKKDATSNVSPCMSLMKKASPQSSGEMLGMPAADRDWVFAFDTASQTIVREQQKCWADNDPECAALVLAFLPEPSLPEPGRVLTLFSPVETRTSEDWHRECEAWTKAFGDGKIRGLVGSIEDEVVYWDHYGRATLSNAKRNYLSTTRREGEDDNDRRQASRFVTTSFDSTGAQTRKAMYTIGRAMAIVRVPSHVELKQLKLGRSRLAVVAELYPPARLLYKSMPFVRTEPTTPAVIPIEAVNKLVGAYYSTKNPRMYVFEDIFDNDGSTMVRVFDFSGAKHHYASGFWRVEIVKGKKLSLCQYLLWYFRPSTRFEGIQTNRPKLFNSNWSSPKRVLDLILRLACEDGAQSRSQINDCHRRAGEQLFADSIIMQEMKRTKSAFVVSHDLTPQVLASDYIDARLDPIDEDNLFISGRIRNLLSQCGDPPPAEPINCDKDPTASTDVEMEEATPENGSDPEQEQEPGHEKRRIEFLYRSVMAQIAFACNRRNNVMQHRNGLIILACGATDRLTTFLLMKANWEIGSNKYFHMTVDNVDVAHHVNDQQLDRRTELLHGTFGYAHIQNGDIAGAYNLRAYSAHQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PNB6</accession>
    <name>A0A2X0PNB6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C048g12358 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C048g12358</name>
        <name evidence="3" type="ORF">BQ5605_C048G12358</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000110">
        <property type="protein sequence ID" value="SGZ30433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PNB6"/>
    <dbReference type="STRING" id="796604.A0A2X0PNB6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016012113" evidence="2">
        <location>
            <begin position="20"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ30433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="303" mass="28247" checksum="CE910E8517C84B61" modified="2018-09-12" version="1">MKLFVVVPTLALLGTFAVANSDLSSTNLEKRCSKALLKGKILGLGACGILQGGLGGCGSSFGPGGAVLNGGLNLRARCPLTFRCNDGFRYDVNGQECPSYLPRGWRYYGVFTGWQPTPSFQCALNWVPPSQWTPYRHLAPWFKFSGGISVGVGAGGGAGVGAGVGAGVGAGVGVGAGAGVGAGAGVGAGGGAGSGAGSGAGAGGGSGAGAGSGAGAGGGSGAGAGAGSGAGAGVGGGAGAGLGGGSGAGAGAGAGAGVGAGAGAGGPGCGKKQGYKHKYMMRHVRRDEVDQEGPNRLGDVMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LQ12</accession>
    <name>A0A2X0LQ12_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C010g05920 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C010g05920</name>
        <name evidence="2" type="ORF">BQ5605_C010G05920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LQ12"/>
    <dbReference type="STRING" id="796604.A0A2X0LQ12"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039196">
        <property type="entry name" value="Fmc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28015">
        <property type="entry name" value="ATP SYNTHASE ASSEMBLY FACTOR FMC1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28015:SF1">
        <property type="entry name" value="ATP SYNTHASE ASSEMBLY FACTOR FMC1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY13629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="131" mass="15067" checksum="8E9DE21756AF631D" modified="2018-09-12" version="1">MATLPRMYRATLRQFVANSIHPRVERSASIPQHLRLIFDEAKSLSRGSKEAKAFERQVEDMVIFLQAHRSHKALVERYNPSSGMTEDEKAHKSARMVGLEYPEAFEAGVEPTMERQKAKQIEKREQQAKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LR50</accession>
    <name>A0A2X0LR50_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial</fullName>
            <shortName evidence="7">Glu-AdT subunit B</shortName>
            <ecNumber evidence="7">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C013g07105</name>
        <name evidence="9" type="ORF">BQ5605_C013G07105</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="7"/>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY14797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LR50"/>
    <dbReference type="STRING" id="796604.A0A2X0LR50"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00121">
        <property type="entry name" value="GatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="GatB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00133">
        <property type="entry name" value="gatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004012">
        <property type="entry name" value="PRK05477.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="GLUTAMYL-TRNA GLN AMIDOTRANSFERASE SUBUNIT B MITOCHONDRIAL AND PROKARYOTIC PET112-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659:SF0">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="GatB/YqeY motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asn/Gln amidotransferase" evidence="8">
        <location>
            <begin position="422"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY14797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="584" mass="63222" checksum="EE9BC133A15CFCC3" modified="2018-09-12" version="1">MATRVAAPIRQLRTPVRLPSCTCNCSSVWTAHHTRSRSISSPASSFAIPSKGKGKASVAQEQRWAGWQPVIGLELHVQLKGNPKLFSSASALYDAEPNTQIQPFDAALPGSLPTLSSEPVRLALLACLALDSSINPVSMFDRKHYFYPDLPAGFQLTQKYAPLAKGGILKIRKDPAAGVTRDLEVRIDQIQLEQDTAKSFHDPSQHMTLVDLNRAGAALIEIVTQPDMRSPEEAASFVRTLQSILRHVGASDANMDKGELRCDVNVSVGPVKGPYGTRCEIKNLNGVRFLVGAIESEISRQINSINAGVPIVQSTMGYDAVNNRTFVLRSKEDAPDYRYMPDPELGPVVVTKTTLDHLRSTLPDLPNKAFERIQTQYGLSPRDAGIVVAVGESLVVDPSSTMSSTPEWLGGSEVGTASIGTRYFETLAVGRQAQVCANWIIHDLLSALGSTSPPLNLLTSPIGPHELGKLIDALSKGKLTSTNAKSLLKEFIVNQTSNSAQGSWNEVLDQAVQSHQSSTSSISLEAICHSVIKDLVQESDKVRKGNTKVLMRLVGQVMKESKGVVDAQEAKKILERTLLPGRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LRG8</accession>
    <name>A0A2X0LRG8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C013g07322 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C013g07322</name>
        <name evidence="7" type="ORF">BQ5605_C013G07322</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LRG8"/>
    <dbReference type="STRING" id="796604.A0A2X0LRG8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12285">
        <property type="entry name" value="RRM3_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029123">
        <property type="entry name" value="RBM39_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006509">
        <property type="entry name" value="RBM39_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48036">
        <property type="entry name" value="SPLICING FACTOR (PAD-1), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G15810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15519">
        <property type="entry name" value="RBM39linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="117"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="240"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="377"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="197"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY15315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="468" mass="51249" checksum="8E96A850F6052314" modified="2018-09-12" version="1">MIAQIENDLATRIVTNENANVKPTAEGSAITTIPVIQKDDVRARAHEMLMNAHVGTGMITTNPNAIDPNVAIPTTDECAMRGVSAVLPVDAILRPTMMSRVATAAEGLPAPKQREMRSIFVSQLSARVGDRELGIFFENQAGKVREARVIVDRISRRSKGVGYVEFVELETVQKALTLSGTKLLGIPIAVQYTEAEKNRQAREPGAVAAGNAPPGGAPATQGQAPPNHDMTRVNRSTLLNRLYVGSLNFALTDEDVRQVFQSFGEITRVDLHRDAITNKSKGYAFVQFKEIAHAQEALEKMNNFVLAGREIKVGLVGDRTMSANRGETQLQQEDGPSLNNISRIELMQKLARSDQPEEMDALKTSVPRPIIPTATTRNVVMANAFNPEEETEPDWDVELRDDVKEECQNSYGPILDIYVLKESKGEIYIRFGAVQDAIKAVAGLNGRFFGGNQITASHTSDQLFDAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LRT5</accession>
    <name>A0A2X0LRT5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C013g07345 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C013g07345</name>
        <name evidence="4" type="ORF">BQ5605_C013G07345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LRT5"/>
    <dbReference type="STRING" id="796604.A0A2X0LRT5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050585">
        <property type="entry name" value="Xaa-Pro_dipeptidyl-ppase/CocE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00976">
        <property type="entry name" value="CocE_NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056:SF10">
        <property type="entry name" value="COCE_NOND FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xaa-Pro dipeptidyl-peptidase C-terminal" evidence="3">
        <location>
            <begin position="330"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="538"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="539"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY15362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="576" mass="64571" checksum="49020F9E6BEBAB3C" modified="2018-09-12" version="1">MPVIQDEIIYRPLNKPQEGVNGYQGFQPGKVETLPKGFTGKGWDGLNSRTLTSDILVEHDVEIVVRDGARLYADIYRPPGSDEKVPVIIGWGPYGKKYSATDMLPVCTWKCGVIPSDLSGFEKFEGLDPAIWCPKGYAIASIDQRGAGCSDGNVQMIGSKDVEDGYDVIEWLAKREWCNGKVGMAGNSYLAISQYFIAALQPPSLAGIAPWDGLSDLYREQFVLGGIFNLSNFALIASLIIRGNGGIEDFAANYRRYPKATSEFWSDKRVDMTKINVPCYLAGSDVSSLHTMGTLRAWTEIGSKDKWLRWGGYQEWFDLYSEPHNQEELLGFFDLYLKGKKNGWAEATPRVRMTILNFGDKDPVENIVVDNWPLPQTLSYNSEVVGSPGTRSFIYTFDKQTRIVGLPKAHLFVSCTASDDLCIYIELRKLDASGKLIKHVQVSTERRWIKKYEDIPEKDHSGVIIHSGSAGMLRASRRKIDPSRTWHPHAPFHPHDEDQKIPPGQIVELEIGIWHMGVQFEAGESLRFDVFGQSSLNSELKEGQGSRPEDERNKGEHMIHFGGEYPSRVILPIVPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LSK5</accession>
    <name>A0A2X0LSK5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C012g06878 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C012g06878</name>
        <name evidence="1" type="ORF">BQ5605_C012G06878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LSK5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY16462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="135" mass="14978" checksum="B02E2A4DF862DCF2" modified="2018-09-12" version="1">MKGLEGVPKLGLNELMGRGVGVFDSCAVELLRLLLVVSIRVEVLWPSSMTKVHSDLSPVDPIHVRPVAPNLVVQVDPQPKSFDSHSSPLLLSLACPIQHQNYWPTPSPKPTRTTSFQSRERIVGLPKRRRCVVQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LSX5</accession>
    <name>A0A2X0LSX5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C094g13076 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C094g13076</name>
        <name evidence="1" type="ORF">BQ5605_C094G13076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000008">
        <property type="protein sequence ID" value="SGY11603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LSX5"/>
    <dbReference type="STRING" id="796604.A0A2X0LSX5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY11603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="74" mass="8192" checksum="633F4985C8E17C44" modified="2018-09-12" version="1">MVRSFALVKIYGMAREGRSLVSGQYPRVKARLVSLYWIAFSRPRRLNSQHSRFSQGRTSGAVGVTSSWGLAAAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LSX8</accession>
    <name>A0A2X0LSX8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C011g06302 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C011g06302</name>
        <name evidence="1" type="ORF">BQ5605_C011G06302</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY11874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LSX8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY11874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="73" mass="8073" checksum="3B1262F766645CD9" modified="2018-09-12" version="1">MSDHSSDDLSHYSIDATDNGAFVLEEWEFNAEDDGSDDETWEIFNGCLESKALVPKASIQTDDASARVLLPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LUL5</accession>
    <name>A0A2X0LUL5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C014g07708 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C014g07708</name>
        <name evidence="1" type="ORF">BQ5605_C014G07708</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY19629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LUL5"/>
    <dbReference type="STRING" id="796604.A0A2X0LUL5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY19629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="139" mass="15136" checksum="6278B8ECD0F42290" modified="2018-09-12" version="1">MLIDYNLAVMKARTAEEESPELRMWCTGAGISSSRFSSVASRTAFQSGSADAPFFETPDAADLWNVWNAEKLKNAASRNEAAKKGWLSTRSGFKELLAACASRWCGVEEVLTILKDSCSIAAAYVDLDGEELEAKLCDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LV02</accession>
    <name>A0A2X0LV02_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C013g07061 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C013g07061</name>
        <name evidence="5" type="ORF">BQ5605_C013G07061</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY14728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LV02"/>
    <dbReference type="STRING" id="796604.A0A2X0LV02"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd21133">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052181">
        <property type="entry name" value="5hmC_binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002740">
        <property type="entry name" value="EVE_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047197">
        <property type="entry name" value="THYN1-like_EVE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14087">
        <property type="entry name" value="THYMOCYTE NUCLEAR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14087:SF7">
        <property type="entry name" value="THYMOCYTE NUCLEAR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01878">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EVE" evidence="4">
        <location>
            <begin position="103"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="259"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY14728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="314" mass="35287" checksum="01B0521E307F9F9C" modified="2018-09-12" version="1">MALSCSWTTTLRILASGQLSRSMPPKVKVKAGTIPDRPVYHHWLLKAEPDTRIEKGVDVKFSVDDFEKCKVTAWEGVRCVVFHSPARSSLLHKVATHPPHFPSRNHQAKRYLKEEMKIDDPCLFYASNCKTPGIAALAKVKREGYPDHNAWDAKHPYYDPKSSSETPTWFMIDLEFVERLPHMVPLKLLQTLSTMEHASLPIEVKEYIKPQHLEAIRGSDLISRGRLSVQGCTDEFYGAVKQLGQRGGWQEWFRGLRGASSSDGAAKAETPSPTKRAKVQEEEEKPVGKRAKKVDPKAASGNSTTGTRRTRSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LVE9</accession>
    <name>A0A2X0LVE9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit d, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C016g08078</name>
        <name evidence="11" type="ORF">BQ5605_C016G08078</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase d subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY20501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LVE9"/>
    <dbReference type="STRING" id="796604.A0A2X0LVE9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008689">
        <property type="entry name" value="ATP_synth_F0_dsu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036228">
        <property type="entry name" value="ATP_synth_F0_dsu_sf_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12700">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT D, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05873">
        <property type="entry name" value="Mt_ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161065">
        <property type="entry name" value="ATP synthase D chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY20501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="265" mass="29643" checksum="833E02E567FD205D" modified="2018-09-12" version="1">MAAAVVDWGRITTKLGLHKDTLSALSAFRQRAAAARTAHTTYSAQARTIDFEHYRSVLKNKEIVAEGEKLFKSFKPVDYDVQAQLKAIAAFETKASNMAQELTTSLFGSRQVASAKETANKIDSELGDLKSTLKNIEDARSFDELTLDDVAKARPEITKAVETMLKKGKWTVPGYTEKLERLLNADKIKKKHTSRRDGWFSRSLIRMTPEVSSLDEERGGGEREGERGLLAMQQLCVIFSNSEFVFGARWASLVGGERFEKWCVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LVP7</accession>
    <name>A0A2X0LVP7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C016g08188 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C016g08188</name>
        <name evidence="2" type="ORF">BQ5605_C016G08188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY21055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LVP7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY21055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="242" mass="27530" checksum="0AFC32349F75F77C" modified="2018-09-12" version="1">MGRHRWRPFKVRLDYFEEHPSYRPQGLRSDARLRTNIPGTRHRVTYTARQIQQGTFDDFGEASSPSPQRPMALPIQADSDEAASDAANPNGMDWDEERYSEYGGGFEHDFDPAPYSPDRTSHFPTSPDYSAIAERLSLADLRQVESFESATRGQSKQETYKQFVFNDGRLRRLERPALLRQYIAFYAGVKGHLRPLIDVDVELCQGSVASEVSPPCSCKSPLTLRLDVGRGADRFLSEIQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-03-27" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LW63</accession>
    <name>A0A2X0LW63_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C013g07369 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C013g07369</name>
        <name evidence="2" type="ORF">BQ5605_C013G07369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LW63"/>
    <dbReference type="STRING" id="796604.A0A2X0LW63"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="29"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY15446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="124" mass="13686" checksum="8121EE5C0B895ED4" modified="2018-09-12" version="1">MGRTTSNPPLLTTSPSLTSYLSPSYNEPFIQLALLTVKEDQGDLAQPLLSKVRQCAESDQEPGCLTFRTSRGSKEEGKGDEFMVYEEYASREALTVHRGLEAFLALANSGLIIKKELILGNEFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LWE0</accession>
    <name>A0A2X0LWE0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C012g06732 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C012g06732</name>
        <name evidence="3" type="ORF">BQ5605_C012G06732</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LWE0"/>
    <dbReference type="STRING" id="796604.A0A2X0LWE0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="2">
        <location>
            <begin position="426"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY16006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="521" mass="57979" checksum="DB09F129C15C3547" modified="2018-09-12" version="1">MTTIQPILALRHVYEPAVQLCRTDSVVSAMANSTLGSPHHHLLRKGECAGLESRSNPSSPTFRSATTSARRRPHFSACCSQGKVRLPPPPQPNLEYRQLLQGSDSEAKAFRENARSYNNALSFTSLAALWDQTQVGTLGSPVFRVFGRLYHRLGALIPAVNQCPAFAQTWLINPAEATDTRLEPDGADSHMQRSTLTKLESMLRTKNHFVREFASAKPRAGWDTAKEWILRLCLPPGRDRRTHNPPTSSTEMAMLICDSDTNTGECGPQDLILQVHGDRCSDGRPKYQVISSLHPGKMASTPTFLFAGSTKPGRQSPETESRSTMVSNCARYLPVSIWMTKTNRRTKTATMRMKTARKGTKRMGMANDEGQVKGSRWRVSRSQFFAHYLPNATSTSQSRIAPNVPSWKPTPHHDPRHQRLDPEPNRDITQRYQDAMACVVKHGKPPLLITMTYDPEAPETKAALGLNDKACTRPDLIAQVFEAKSGNKRHAGCFGDECRMNGFVSLLYFVGCFLNLCAEIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LWL6</accession>
    <name>A0A2X0LWL6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C018g08650 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C018g08650</name>
        <name evidence="8" type="ORF">BQ5605_C018G08650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY25632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LWL6"/>
    <dbReference type="STRING" id="796604.A0A2X0LWL6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.20">
        <property type="entry name" value="DHHA2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1640.10">
        <property type="entry name" value="inorganic pyrophosphatase (n-terminal core)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004097">
        <property type="entry name" value="DHHA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038222">
        <property type="entry name" value="DHHA2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112">
        <property type="entry name" value="BNIP - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112:SF20">
        <property type="entry name" value="EXOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02833">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016007005" evidence="5">
        <location>
            <begin position="23"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="DDH" evidence="6">
        <location>
            <begin position="86"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA2" evidence="7">
        <location>
            <begin position="329"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY25632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="523" mass="58561" checksum="6C62E2FE8729BC13" modified="2018-09-12" version="1">MVGPSSLLQVLVSLTFLPALLALPSPTAAPKQLVLVPDEARQAPPTMPMPGKNESGHGHFSKWSRKTKKQFLYDLSYAPAKAQDWVIVMGNEAGDLDSMVSALAMSYTMMHLKKPVKAVALLQTEQGTSPINDQRDAVSHVYALYLRPENSLALHKARMASHHRDLLTIDELLIKPQDMWHRIKGIALVDHNVPTSVWGNTTVVSIIDHHTDRGVAPHASPRIVEVTASCTSLVAKWMLDLFDSGKAQAKNDHLPHELIEIMLRTIAIDSSGLKKATPIDEEATLGLWAKSKWSKHHFEPLEPFVRSQAAGDVKEIDEEIKNRMKAIDDELSQAKKNLTGLDVRALLRRDWKGGVLTTKSEKYPHLSLGFASAPVSLAEQIERTPEGFPQEWFAIERAWTAEIGADVSVCLTSFKDEKGKKTRELALVVAHGFGKRLHEHAADSLFQTLKRSIENAGVEDLQVWERPDGKPLLPRRAVYRHHDSTASRKMWRPVIEKAAMEWTGDDVDDDDPYQRRHKHHDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZA4</accession>
    <name>A0A2X0LZA4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C016g08123 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C016g08123</name>
        <name evidence="7" type="ORF">BQ5605_C016G08123</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY20681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LZA4"/>
    <dbReference type="STRING" id="796604.A0A2X0LZA4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009081">
        <property type="term" value="P:branched-chain amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825">
        <property type="entry name" value="AMINO ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825:SF2">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE 3, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY20681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="371" mass="39920" checksum="72BACEBF5DAA3E71" modified="2018-09-12" version="1">MPAVVPPSDTFAWDKLAFALYPTSGYVSYTYKDGAWGKAEWVSEPYLKLHVGSVALNYGASTFEGLKAFRHPDGQVRLFRPKDNAARIQHSAEVVSMPPVPEELFLEAVSLAVGRNLDLVPPHAPHGASGSMYVRPLAFASGENLILAPPSEFQFIVYVTPTGSLYGTAGLKAPAIDAFVLETFDRAAPRGVGHAKLAGNYAPTFRHAAAVKQAGYAITLHLDSATRTQIDEFSTSNFLAIKKRSSSDDDKVTLVVPTSESILKSVTTKAIIGIAESFGWTVDRRIVKFSEVIEGAFEEVAACGTAAALTPIRSITYHDTPETTQKISIGDGVNAGPRFLSILSELTGIQSGTIPDKFDWTWPKEGIDGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZC7</accession>
    <name>A0A2X0LZC7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C016g08153 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C016g08153</name>
        <name evidence="2" type="ORF">BQ5605_C016G08153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY20841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LZC7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY20841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="273" mass="29401" checksum="AC1795FF4D4D6BB8" modified="2018-09-12" version="1">MTASSVAVCSGICSTCSASGLGDALTLFQMLAMSKLERWRCLAARATGKGELSTTGESDGGRSKGGEPAGPKLSRRSETGDGATLAPSSELANMDSGRGGALESFPEREGDPGLMIGEVSRTMGDRVCGGGDPLPYLKGDMDESVLFLLKKSLTRIRPNFFLTLVRPLGRRNPNHLLDRMLQTRGSHRFSHLLQLRPHQILIRHRHDLHRAQFVRRDPFAKVLVGLEVVVQRTELAAVFGSGTADVGFEVDFGEPLEQVAFDVGREGDGAILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZC8</accession>
    <name>A0A2X0LZC8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01666 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01666</name>
        <name evidence="2" type="ORF">BQ5605_C002G01666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY34671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LZC8"/>
    <dbReference type="STRING" id="796604.A0A2X0LZC8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY34671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="544" mass="59475" checksum="E2B6ED813868BD86" modified="2018-09-12" version="1">MDFSLQVNASQTDSSTGYHHTYDDTTAIDLSALGSYPSDTQIIQASQEAARLARDLLEATKMWPNLVEAGARPPNQFQEDIMVDEGESETVACQVSSYITVVNDTQPIIYQMRMIYSSTTPGHLQLEEQAAVESAICALTALDIDVEDMLDSIRTHYDQARQQQAEAEEGNKVQEELNQHYAEFQPAGLHEKAKVDMLPLGGLAQRSQRGAELLLDQLKAHRNAHQCDHLKAILKGRQSAAISSTASDSNGSNQSPQGSHAAVHSAILRGLLESTNDERWRKLTGMSRNVRWTGGGTAGREMTEHEVETRQNTQDARSHKGIGARAVRYRQLDQQHPHLGASIGSVSAKNPLKIGSLVVFGLHHTQSCDELDLKIRNGEGLALGYVRYIYTKPSPAMPRCSVESTESLGLVSNIVIQELFPTQASSGVFTNRNSRGQARIFFLNGHRVVSCLDTYNSSMQTVEPPAGFGFDGHTWRVLDPQAQARYYQLQSFKGVLAASLAPIRKGLAHAGEERGINADGGSGADKRSGSSQGPSGRLSKRTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M099</accession>
    <name>A0A2X0M099_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C019g08986 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C019g08986</name>
        <name evidence="3" type="ORF">BQ5605_C019G08986</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY23825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M099"/>
    <dbReference type="STRING" id="796604.A0A2X0M099"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.20">
        <property type="entry name" value="Hypothetical protein ph0010, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.150">
        <property type="entry name" value="Hypothetical protein ph0010, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023473">
        <property type="entry name" value="AMMECR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036071">
        <property type="entry name" value="AMMECR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002733">
        <property type="entry name" value="AMMECR1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027485">
        <property type="entry name" value="AMMECR1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016:SF0">
        <property type="entry name" value="AMME SYNDROME CANDIDATE GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016">
        <property type="entry name" value="AMMECR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01871">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143447">
        <property type="entry name" value="AMMECR1-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51112">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMMECR1" evidence="2">
        <location>
            <begin position="10"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY23825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="289" mass="31658" checksum="FE643533397F3460" modified="2018-09-12" version="1">MSPITAASASDESDQGALPEHAYYCFDVIDSKLNSTSLPAPEFDGKLQYPLFVTWNIKSRSSDTTRLRGCIGNFEPMKIGTGLRDYAAISAFDDHRFDPITAKEVPRLECGVSFLTDFELCDNYLDWTIGTHGIYIQLPNPSVFKPKPYIPPSPLSSTPSSTATSSASSLSLDSRSSSASTTASSVPSPSSSSTKTPPIRPTYRSISQLPPMQLDKAPRSSSRAVLSATYLPDVASEQGWTQLEAIDSVIRKSGYSGRITQDIRDSLRLTRYQSKKVHVTWKEWKAARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M1W9</accession>
    <name>A0A2X0M1W9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C002g01182 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C002g01182</name>
        <name evidence="4" type="ORF">BQ5605_C002G01182</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY30785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M1W9"/>
    <dbReference type="STRING" id="796604.A0A2X0M1W9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000051">
        <property type="entry name" value="Probable MDR1-Mac1p interacting protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000002">
        <property type="entry name" value="TBC1 domain family member 9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="292"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="613"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="791"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1038"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="626"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="645"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="791"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY30785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1083" mass="121073" checksum="9E0D5B9050B5394A" modified="2018-09-12" version="1">MSLRVQQRRTYFTEPTKDGHRTSDATAIFDEPTFRKRPHIALQALFREAFGLPEEEEPLGEVHAVLTMQGKEEAYSGKLYLSTSFLAFTSLDRRSCRFTLPLATVRRVEKLAPGQDGTSAGAFALSLTLLHHLRIVIQLNSLRPTNDAFCATLRRRLKASLPMMKALSPFSRTFFSEHYLNPVSGKDDADADGKGASEKAEPEVGQLISFGEGDFEANDFKGKQKEVKEYTIEAGTGHGFHGGLGLVFKFPGDPRKLREKSKMKLWKEYLTHHGRNLTLVRYPSFTRLVLVGLPNRLRGEIWELTCGSMYMRLHNPGVYDKILEDNEGRRSASTDDIEKDLHRSLPEYAAYQDKAGIDAMRRVLTAYSWSNPSVGYCQAMNLIAASFLIYMSEEQCFWTLTVLCDRLLPGYYSPSMYGTVLDQRVFEHLVQKCLPMIHDHFSEADVQLSVASLPWFLSLYISSLPMVFAFRIIDCFFLMGPKVLFQVGLAILKVNGEELLQTSDDGAFINVLKSYFATLGDSVHPESRDPKMRQITKFQELFVVAFREFASITDETIASERKRFRSEVVVSIETFAKRSAIRNLRSTGRLSKEQLGLAYDHFQLALLRSTERSRKRGYSSSGGSLKTPSQRSRGTSGPSAEEGSVAEKQDGEKPEPRIDREAFGTFLGDIASWARDEKVVKNGFHEHVEREPVDHALVDRIFHNWDETGAQGLSFQDVVTGLDSILFNDLMMNLAWLFSIHDGDRDGHLTRDEALQVSESLLYMFRNEPGDRYLGSVSNLIQNLFEFAESSAHETAPDPHTGRTRPPSAENDDPQKPALALATFRMCVLADPLLEDFFESDLTASWRLEILLAEDQPKQAKGAVGGWWGGIISAVMTDENKVRQFLLREQSERINRIADEVGKRLDIQTVEQSKRLSPCFRECRVFSSCISQTTGPSIGKLDAAAAAIEPTARDSLFSTSTKPASARNPTPVAAVESAPAVNPLSAAAMRMPAYPPVMNPWANEPASTKVGALTREIDVQDLARQVAEERTQFADDQFVIDNEGEEDADLGAGDLDGDLMNQVDQMLDGDQQKPTAAREGECD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M228</accession>
    <name>A0A2X0M228_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C002g01231 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C002g01231</name>
        <name evidence="3" type="ORF">BQ5605_C002G01231</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY31443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M228"/>
    <dbReference type="STRING" id="796604.A0A2X0M228"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000795">
        <property type="term" value="C:synaptonemal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042448">
        <property type="entry name" value="CCNB1IP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14305">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CCNB1IP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14305:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CCNB1IP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="204"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="349"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="112"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY31443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="424" mass="45345" checksum="6B639E8241678CEE" modified="2018-09-12" version="1">MDDIKCNSLKCRKSLQLEGTSHIFCVECANSLFSVPQICPACDTALPDADDVVQTTLNPPDSYKTSVLSGLHPSIILDVASRALNFHTYQTQQEAAFQALVTRNTQEMSSIMRDANSEITLLKEKVAETERDLELERRRIRDLHETHKANAKAYNKLKAQYDKEKQRNLLPSSERHPSNTFEAAAAAIAGNTSGARQPFASIQDAGTATPARSHSSSSIISQPDRGWSASAQRNQYARNAQKLGGGDAGAGGVPFAYNPGDSVQRPRNTFQGDHTQLHNSRHAPQQRHGAAMKGLRRGTNHSTGSGSTGSDGGGKQDHFVQTFQGQNSAREAGQHKMDGTRSRAGEENLPQFLGQPLPSPRGGTGGGGQPGQKLKGGQCIGSFTCFAIPSCSNLTWPSENPSTISTLMTPKSGPAPAGAREGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M380</accession>
    <name>A0A2X0M380_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C001g00403 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C001g00403</name>
        <name evidence="8" type="ORF">BQ5605_C001G00403</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY46258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0M380"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034993">
        <property type="term" value="C:meiotic nuclear membrane microtubule tethering complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045119">
        <property type="entry name" value="SUN1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911:SF8">
        <property type="entry name" value="KLAROID PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911">
        <property type="entry name" value="SAD1/UNC-84-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SUN" evidence="7">
        <location>
            <begin position="1103"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="175"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="228"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="529"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="771"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="327"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="430"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="544"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY46258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1319" mass="141953" checksum="F8BDA4DA18248A95" modified="2018-09-12" version="1">MAPRSRSPAAVPVLNSVSVTGSGTNPTSRGGDQHASTSASTFTSQVPHHERRLSNPAMPVSYAYGAPPAPVGSSPLGSPASRSSNRRVNTGESNDAQSTSSNSRRGAPLRAQSLLRGEVEAGQDETILITGEDDEEEEDEDSFELEKQRHLEREESIGRSLEPAAVRYARLAERKRNTGSALRQPTNFGTTTTTGVASTSSSKTRPATDLNNTSVNIANAFAAAVKGTSSAEGLMRVGGKRATMPVSTQETVGQEDASEEEDSGKETHCAGGGAGTDGSKKRKKRNSTPKDASFKHRTGETTSEEELSEEARAKAKRPKKTTSTTSPERERGNDAEKEHVSGQKKTSPNARRKLTTTDSAYKPTGESEATSGDDISDDAIARRRKSKGKGRASTGSATLSAIPIGRRDNEVWQKAKKRKGRKGRGTGEGEGVDDEGAGSDDEYARNDDKEQDMGGMEHDFEPNISVEPPSVSFFLRDKSPSDRTQASAQKEVVTPQLKLGGYPTSSPGTHSPFQPLRAFTFGFGGRGANAAAPPVDPSFDDFDQTLNPGRTQPSHSFSRSLSLDDSLTRSSSYDYSEEERIVAALEEQRRLNQLATEQSKGGAGDGVNSLTAGLRRRHRLNGAPALAGIQEESQHVRRSGIGAFLGRQLYRLFAGVWRTIQDPLLDWRKIWRAIGLLLLGLLAMVYLVLVRSPNLTSDSPSKSASSSDHSPSIIHYVPFFRPSSTYRAPATPADSLEELIARLTLLEGAMGQLSSLTDGDRTRTKENNQLMSKIAEQLSSLEQTLSAERQNAAKAIESSVKANTKQNHELEQTLKGARADLDALVTRVQTFQDAHSDDAADLRKLKASIDAAAKDIASLGGKVAQVAQDVRKGLDGERMAKVALEAIEQRLPPKMAVKVNENGKVEVDATFWQYLRDAFVDKKEVESIVNSKVAREVAKLPLKTDGGGPLAPIVIHEPPKWDDFLEANDAALRALVSSNIEGRTGSDAIVTRRAFLDTLRREIKTLKADFEAKANENVERIGQELLRKVAKQEEMKRKESGGGGIASHLHLPFTGHKGGEGGSSATIPSDNVAALVSSLVDSALLRYSKDVLARPDYALFTAGGRVVRTLTSPTYEANPLGASRRALAWVTGTAGPRGRPPVTALHPDNAPGSCWPFAGSRGQLGIQLSRSIVPSDVTIEHVSIDVSLDGTVASAPREFEVWGVVESRSDIDRLARYRYEQLEARRKAEVQGDDEARGFELEPPTSIPPTPDHILLAIGSYDAASPAPIQTFPVTPMARQLAIPVQVVVLKVLTNHGESAYTCLYRVRVGGTSTTISAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M383</accession>
    <name>A0A2X0M383_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01722 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01722</name>
        <name evidence="2" type="ORF">BQ5605_C002G01722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY35063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M383"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY35063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="182" mass="19592" checksum="C3AFA67ECFDA71E2" modified="2018-09-12" version="1">MSFEDSRAAWRLRQRAVPYPTMPTIAVRERAFKSGRALTGRADASSSALRDGAPAAAPPPTVKLDRNPGACLGFTSTSNPRLPMLRSSHSGDIVVYLPEADGNEMAPMASSTNCTPEERLCAAFAKTYRGINRILVLTPTTPVQLPLHACALAAIEHAVMVAAGRTAESNEMYAMCILRYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M3Q3</accession>
    <name>A0A2X0M3Q3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">BQ5605_C001g00560 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">BQ5605_C001g00560</name>
        <name evidence="17" type="ORF">BQ5605_C001G00560</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM CWC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY47694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M3Q3"/>
    <dbReference type="STRING" id="796604.A0A2X0M3Q3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12360">
        <property type="entry name" value="RRM_cwf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034181">
        <property type="entry name" value="Cwc2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032297">
        <property type="entry name" value="Torus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16131">
        <property type="entry name" value="Torus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="16">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="158"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="13">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="290"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="362"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="362"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="SGY47694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="393" mass="43698" checksum="BC78AA98AEACCA10" modified="2018-09-12" version="1">MAPSPPSSSTAVVPSQQQEPLVKKKKMVKRPPARKQVEVGQVVKKAPEQTGSTFNVWYHKWAGGDKYDEYNVKEKSQTRVDLKKDSGYTKADGDGTKYLCLFFARGCCPLGHECSYLHRLPPSQHELPDASLDVFGREKHSDYRDDMGGVGSFTRMNRTLYIGRLVETRDTAEMIERHFEEFGEIERIKILSSRGVAFVTYVSELNAQFAKEAMMHQSLDSDEILNVRYSLLTYPPSPIRRWATEDPNPAAKRRNRRELEQAGEDGIAATLDPEFVRRVRELDELEGLVEPLPAEMPEIEAARDEKPDEEEEGRQNKRARIEAPPTPTTGTQNGAHEPVKAGGILSANAIDSLKYIASLRQATAAPTSKTAAPPTHANALGGLAAYGSDEESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M4G7</accession>
    <name>A0A2X0M4G7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C001g00823 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C001g00823</name>
        <name evidence="9" type="ORF">BQ5605_C001G00823</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY49821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M4G7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461:SF69">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="772"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY49821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="865" mass="97202" checksum="1DDEE5060862341F" modified="2018-09-12" version="1">MTQWLHLPICQALLSQLPTRRSHGLAVDSALGANSGARDHRDRRHWCTDYRLWFATLLICSICVLNSYHFQAKALMLSWLQQSTSSDSGPLERRPPLKQTIVAGVLSPDSSSGQDFGDDNAINDLPAWADYDAISSFTLPLSNTIVPVIMHHFDVAHLRAPYDQVYLVSAFVDPRPLVVPNARREIIIHAVLNRIRLFHETHYPDNVIECSVLIRQPDGTVIATTGRAKSSPAYHYRGGYLTLSQAQIVCSLARIPQLTYDAIAWEKAEIYVSVNPINFSPAPDAFIFARSVAALDVDEHRTGRGQGAVCLAPLRGELYSSSVKDHVSYQKSLGFTRIYIYLLDPGPITLSVLRKLASADPDIVLVRWGILKNWVIRSDSLRGTFAVDPSRWNLPGIEPLEPAREALLGTARSSKSLAVWYWGQNLAAQDCYLRSMADGVRWVASVDWDEYLVLQPAGKLTWDVPPRSADPIEAIAPFVQWTRDLRRSFNISTQGGYILRPDHRVMVDVDFITEGMLPSCMVFSQSLGRSTCRILSSPPQTPMLEEIMDRFGTWDWLKPGATVPAAFSTPVGNPYLFWGHRSKKVLDPWAYFLDSTHRIEVGYATYVLRDGVCSLTSSIIVNKEMSPSDCIEFVLRAFGGHPVLVPVTKAVVRHRPDFAGQSSEITGSSGSLRHFRVDMSVVLGTLQVTKQLTDFSPMLLSSPESHKVRSNHIRGICENSTEDWTLVQVMEQSLKRVFEDRIEGTVPSNQRPTPDVVVTTKQVPRPALPSPFAPSTAALLAVIAIPPLVYVLVTRLRYHKRKRLEGYEMSERRRLVKLRVLFFHSIWKLCRRRRFSSDLWEPIIEMDFEGLRASIQESKGRLVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M6C9</accession>
    <name>A0A2X0M6C9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C001g00118 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C001g00118</name>
        <name evidence="1" type="ORF">BQ5605_C001G00118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY44121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M6C9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY44121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="308" mass="34676" checksum="3E258C86EFDE8343" modified="2018-09-12" version="1">MVPKPFIENDCTPIRNTQPLPHRLIVSNLPAIFGDIAKQTAEASLEHLSMAGIGPNHQPAFFESHKIGYPTGLPDPPQSRYKALNTDYFEIILAGKRSRSSLPVTSSIPQKIHAFLNANPYREWSKVPPRFNPRVHLLTAQFLNRADPSTFATPLLDGDGNLWPPPEDLLRKAVKAHIDKHFEDMLDVPAESCISVTTESSTRHDRTAAIEPLRLKSQRFYHVECLIQFTGKQKQTKKRKKKPFIAETACPFKHSCNEIWTVACFVVRPQCSLDFRPFANGVARHRDEQPGGFPCAIVASVQVVRKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M6F3</accession>
    <name>A0A2X0M6F3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C001g00319 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C001g00319</name>
        <name evidence="3" type="ORF">BQ5605_C001G00319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY45684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M6F3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="256"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY45684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="298" mass="32054" checksum="6BFEB4927EE39A0A" modified="2018-09-12" version="1">MTFGSRSTRPNYSCCSCLLGGGAHRHLKVHSTTIIHQGTLHEVAALLTDRVWRKIERPILSHVAALREQRLSDETRQILLDRFREEAARAQEAAAERHSQELQELRERDRSAQAAVAATLAAHAQRTAASGSPAVGGSTSSFGTGIGQSPQRPVGNGMPPSSLTSAWNPSLAHQQQQQQQQQQQHQQPCQAHAQYLNALRYGSAHGLRSTSAPSASPLYPSMGSYQRPAAANTLMNPAVIRQPVLVPNLTRITPSGSNAPDHSLGAWWLGSSPRSNPAHQSTSLPSRAHLPTPSSTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M760</accession>
    <name>A0A2X0M760_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C001g00307 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C001g00307</name>
        <name evidence="3" type="ORF">BQ5605_C001G00307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY45605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF463">
        <property type="entry name" value="REVERSE TRANSCRIPTASE TY1_COPIA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="64"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="601"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY45605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1296" mass="146100" checksum="A9DF4AE8054DABC0" modified="2018-09-12" version="1">MVDVLDTPPMFHDKLSYDAYCAAVFAEEDIEIPKTFEEAMKSPYCNHWSAAMVSELLQFDHHGVFQEVKWHEGIRVLGTIWVYSIKRNANSKIIRFKARLVAQGFAQRPGIDYHDTYAPVARSSMILFLIALAAAQGLYLEQFNFDCAFLNGKMTEDVYVRYPKGWNRPQSPGKCLKLVGSMYGTKQAPRYMRATADACLYIKHSGTSFAIITLYVDDGLIASNNQSFLDSELGSLHKAFQLKRLGPVSYFLGFEIHRTKDYILVHQSKYVRTMLEKFDFSSPSKRRAITPMDDRPSLRIDTTPFADVSLYQSAVGSLQYASTRCRPDIAIAVRAVAQKNSCPTVDDWAAVKHIFRYLNSTIDLGILYRNSSTTRLMVYSDASFADDPESRRSVGAYASMLAGGVISWQSNQQSMIATSTTKAEILSASSATREAIWLRRLAGDVGIPQAQPTIIQEDNAACIQIAKDPVDHMRTKHFDIAHLFVRERVASGEVELEYCPTHVNAADIMTKPLGFQRFDQLRALLGMVSLVSLTGGSFLQKQKQNGFRRMVRLFALVKIYGMAREGRSLVSGQYPRVKARLVSLYWIAFLSAPTAQQPALEIQPREDIRRSPNKKTKKTKNGETSTARYIVNGFLTETVRLLCGLGQGNPLSSSVWDVVFQPFLDSLSRRNIALTITLPELAPRPQTRCITNLAFADDAVVAVAGPEAIASLEALARDWRLATNGRLNTDKTVVMPLGTTLWDRADLSKLSFVAPDESLPWIGLQFAPDGNNRLGFHDLERRVDRVILSVRDRWMTHHTRAFYLNRYGISKVLHSLSADIPPSDVIKAIERKLADFVKGRPRRSDYKQSVVFTTRARGGLSVVSIQDVVDSVSVRIWDVLAGGSTAIWGDLARSSIRRALPTFDFAADLWTWRNADAPRELHPRWRAVLSVAERYPAVVDPAKLSVPNFLSLSPLQPGLHDSRAFSEQDKRLAKHFSFERTIADIYARAQYPAAPTVPWTPEKHPQGDGSELSNLWQWKRDQVQAWIQVAGDRFIPPLPPPVPVLARRPPVIRVVGAPGVRPGGPLEHVLPRATPVGMPDQKLPLPSAPFRADQWKMLSLDRPYTIARLRRVINHRRFDDTQRPGSLATPKERRLFWVWFNTGPATAREREVHFKLAYHFTPTRKRQFVQRHGDSACCLVQACSLAGVEDDFTHFWHDCPDSSQFWQAARSILCDALGVVSILDLDYTALQIEHGLPRLRARLPTSKKRPIRAFIALARDTLSNRRWDLHRHARAMSSMDKEMAGLKERLELRLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M830</accession>
    <name>A0A2X0M830_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00658 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00658</name>
        <name evidence="2" type="ORF">BQ5605_C001G00658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY48520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M830"/>
    <dbReference type="STRING" id="796604.A0A2X0M830"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019193">
        <property type="entry name" value="UBQ-conj_enz_E2-bd_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09814">
        <property type="entry name" value="HECT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="700"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="703"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="717"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY48520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1183" mass="128313" checksum="12A2312E73A42BE6" modified="2018-09-12" version="1">MTTLERPRSSVTNDGSRSTSPLQASFDPFAVPRAPIAADLDREGALRFPTASSADRSLLSMHGHDELDLIELGQEQLFSGARTATATTSSAMPPPLPPKAVGRGAPLLGTPTAVSEESFGQLGAAKLAFLSALQGLLQPLLRPRSDELTTSQATQLMNSIPIASTSRANAPTDAFIWLAQDSTGPGSGLSPPQALTAPAAQAEDELLAHLINGLRAQAIVRWEDANVDGQSHVLSSTGSCLPETETTSTPVSRLALATELQARIDRLAPALPPTDAQLAHNLGALIVSIERLVHVGHTFVAPVPLPTQPGPGPASASVSLTTDRGAELSASSVYSANVYQRLEREAKALQQSKNEGLLHDAAHALSSVFGAAREVERAERDLLWGRIDDLSERVRALCRERAEADAIFAEDQSFISCAREGQFAHINAYSSLRSSTMFALSVAGVTGDLPSYSHDPSLVELEHPQLPPSYFADHVVDCKVERHNEGEAAPLTHQASHRSNEKRQRDLDSVSHAIERLYAVSPQLANQRVEPDRRALRERQLAKLGNAIERLSKGRLDDQRAVSVSSADEDPGEKAARNQRIQEVMLDKLIDQINRAASRTLSDQRVDVNGGEQRGIVKPSSPFVPSDLNEAARREFILHHTGKGRLASQDAELPSHYPVEIFPGPPPTGSLSPADYSLYGSPPVDGGSLKKRFSTLRLGMFKRPGSPSASRRPSYDSRINSPSEATPSSPMSRLGSADRGARRASVESTGLGVLGLGNALRRPVGPFDAPAPPVIDYLVEEARNLGSLVVSFWPRSPGSARQEWEVKSLEGESILVGPTIGGEPSRIILPSRVATQVAHVTPRGSYFEVKLVAFEPSPTRSRPDLEIHTPLSTAELRESLPRSFACSTCHSEVVDASAITKYNALPSEHWAELLDAWMCHQDQTLSDDLIAKGKGIQPRAGEGLVGSSYLLFDRALAKNWHRMPFADELERTENGDPLYPAQCDSCSSMIGFEVSPAQASDTSTKCFRLLKFATYPLSLRIPGSPLKDARRYSLASQITAELLELGQAHACHRLIVEDREHDKARLLLWLFNPSVRLSFSVMTTPAVEVLEDSSRQPSGAVSGTEPTTRRSMNAVKIFYIVVENEMDEKCQEFIASPMSTCERTQYPSSVITRLTDLLRASSSIYPSDKRHWGQLEVGFLERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M995</accession>
    <name>A0A2X0M995_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C004g02923 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C004g02923</name>
        <name evidence="7" type="ORF">BQ5605_C004G02923</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY68837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M995"/>
    <dbReference type="STRING" id="796604.A0A2X0M995"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="497"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="554"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="6">
        <location>
            <begin position="107"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY68837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="602" mass="66875" checksum="921E1B70CF3F22D3" modified="2018-09-12" version="1">MATSSDNSPPLSSASSDTVVEDLRKPTRTRRGRRSSSTSATSSSWNASRQAVLNVVHLISPWTWFNSFLNLFYALCNAGYQIYQAGVDLLFTAPYRPLPDGVEPFGRVAIIGAGLSGISSAAHLVAHGFDVVIYEADDKIGGIWANVNSTSSLQLNSLLYRFHPSVRWSCGFPQQPEIVSKIQTVFERYHLGPRTRLSTRVTKIVRDKGSSTDPNKGGHARWIVNDGEDGVFDAVIATVGTCGTPKWIDFPHKDKFQGRLLVSAAHRSASLGVNSRKADLAHAPPLLPQHSSQLDSIGDLKGKKVVVLGSGASGVEAAELAVSKKASEIVVLARTDKWVIPRSTVFDVLLSLQPFGREMPLSFIPEWFIRAFHYRDLANLSPKRKGIFQGTPIVNNDFLNHIREGKIAYKRGDTQEFTAQGVRFSERERDQDIGEEGIDTVVTADIVVFATGYERPSIDFLPKDLFPVEGARDYQPPNLYIQMFSTEDCSVLLTNAAYLDAIGTVGSFHIGVFARVLMLFLLDKRTRPMPKSMKTWIDVINWIKRTAFGEHGTSGLAFFTYAELLIWLVVFHFFKLARLAWMPFVLFGWGVKPTMSRKYVHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M9E0</accession>
    <name>A0A2X0M9E0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g03844 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g03844</name>
        <name evidence="1" type="ORF">BQ5605_C006G03844</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY54137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M9E0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY54137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="152" mass="17666" checksum="3BCA9037165F9D3A" modified="2018-09-12" version="1">MPIAELLAFGVSCRSRRRVSLHRVTRDVFLATDALIRISTFGRRVDKQYGALAQRSRHFGSLDGVELRFIKKACYFTHIDGTMPFRMIDGRQNLYKPHNCHRGYKELKFGKTKALLMPGATRDTCRSDRAPQATFDWPPRARKRSERVFEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M9S1</accession>
    <name>A0A2X0M9S1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C006g03974 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C006g03974</name>
        <name evidence="5" type="ORF">BQ5605_C006G03974</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY55133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="737"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="392"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1002"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="400"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1009"/>
            <end position="1019"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY55133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1572" mass="172106" checksum="636CCD905B619B75" modified="2018-09-12" version="1">MATPTADHVSLMGDLYGKVDATNWGVARERLQNVLKGEGRLKHVTGVLDVGPEPLQSEFTRLEGDNRVDDVATYRNQLRLYRQDVDALDQALAQARNTLIVCLGESTFARVKANATHDLWAALDKDLGRASDDFMRSAKLDALFLCEPFVDGEALDPWLANFNRLFEDLVAAHVSRDKAYQRARIDGTSFTQSDFDKWVPPPALSEGVRMDLLKARMPRNLVTVIDSIGTLPSLEQVEGAIRRAALSSSRQIEPIAEALAARVQSRSQPASGRPRAASRVPGLKERWPHGISHAGRLKLGRMQCRRCYEQGHLGDECTVPSAESDFDKWVPAPALSEGVRMDLLKARMPRNLVTVIDSIGTLPSLEQVEGAIRRAALSSSRQIEPIAEALAARVQSRSQPASGRPRSKPSGRPSGPSAPPFLQASRVPGLKERWPHGISHAGRLKLGRMQCRRCYEQGHLGDECTVPSAEVSRRRIAVLAKHNITIGAADVMALVAVDRAPEAQLEDEAYKGYFVVGVPIGDDDTALYLSDIPRYLLDSGATRHMTTCRDLLIDFKPFTTERVRVVGAFNSSAMATGTGTLRFGVDEASIELHDVLLVPGLSAELVSLAGLMKDGYELSNECDAAGKHTGIAISSATSRLSFALDRNHYVLQASSHPPPRADHLALTATTLPTDVVLWHQRLGHPSWGRLVELVRSGQIPLDVAAVTPDQIRLLDQCDACCAGKTVSSPNREPASHPADAPFSRVFADVWGPSPVPALSGARYLCGITDEFSRFRWARSIRLKSDSSAVLQDFVAMSKTQYGGQGVTTLRTDRGGEFERSWRTIFNSVRAWLHRSGLPPALWDEAVHAAIYVINLLPSSPLQQHTPDSVLHEPSDPVTDTRRPRLDRVKTWGCAAHVPLAPEQRPNKLAPRSRLCYFVGYSLRSKAWRFFDPVRNKVFESSQARFFEDRFFPPAVSPAMPAIPVAVGLSYPPAPLGIGSAAAPPVAKAPAVAPAAAAPPPVPPALAFSNPGPANAPPNGDRSTRTRRPPDYLGFAHAAQHWEFANHAAIQFDDFDEGDPDTQMYSFEEVSALLAKIDSDDTPSVQAALAGPFRDYWLAAMSVEEGALAAKNAFSKPVRPPPGAIVIGSMWVLLVKRNAEGRAASHRLLLALAVENEWETRQFDVSSAYLNGNLGGTEIYMRLPGGDIVRLQHALYGLVQAGREWYKVFTEWILSIGFTRTDSDHAVFVCKEGDRRSFLSIHVNDGLLTGDGDLDGVLCQLKARFEARSTDEASFFLGQSIRREGKTGAAIVNQGHFVDAILEEHHMANASPRPTPLAAPSTLRNRADSGFDPASIPYRAIVGKLLYLSGTTRPDIAFAVSKAARFCNDFTAEHWEALKHILRYLVGTRNFGIRYQKSFQPMSAILEGFVNADHGADPVTRRSVSGYVFMCAGGAISWVAKRQTLVTLSSTEAEYVAMSYAAREGIWLRRLLADLGFEQTAPTRLRGDNQSAITLAKHPAFHARTKHIGIHFHFIRDHIAEGTIEMVWVPTGTMAADVLTKGLGTQKHYQFVHAMGLIDSSREGASWRVVNED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MAR0</accession>
    <name>A0A2X0MAR0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C011g06645 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C011g06645</name>
        <name evidence="3" type="ORF">BQ5605_C011G06645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MAR0"/>
    <dbReference type="STRING" id="796604.A0A2X0MAR0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY12892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="55" mass="5904" checksum="7D838D54CD549361" modified="2018-09-12" version="1">MWGQLLKSSFPRLASHRALASDTGGSTRLPAAYCGVLGFKPSYGLFLLLYLAKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MAU0</accession>
    <name>A0A2X0MAU0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C005g03432 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C005g03432</name>
        <name evidence="1" type="ORF">BQ5605_C005G03432</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY75565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MAU0"/>
    <dbReference type="STRING" id="796604.A0A2X0MAU0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016340">
        <property type="entry name" value="Ribosomal_mL60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28271">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L31, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28271:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09784">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY75565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="103" mass="11840" checksum="F4CA632ED1B5119A" modified="2018-09-12" version="1">MLFKPSLPLSVGLLWKNPWRMSQTRKMRARLRLKTVDHNIAVVEQASPSTLSLKAALALPTEASMPARDKYTTFSRTERGYRKSMHKVPKWTKLTNRTNPLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MB77</accession>
    <name>A0A2X0MB77_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C007g04454 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C007g04454</name>
        <name evidence="25" type="ORF">BQ5605_C007G04454</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY60597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MB77"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
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        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="493"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="849"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="861"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="879"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGY60597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1107" mass="120328" checksum="EC717C7EB612AD29" modified="2018-09-12" version="1">MSTPLMVTGGTTPIVLVKPRDVDPSCHLRNAGGWSQWIDDVRGALGGDYWNCTLATPVQSPNTRTDLDHANFQAVALLMRSVSPDIRKHIKDGYDHTPAEVLQMIKKAVGTGTVADILIRLQALLDVGPPPTGMDAFAKYQATTIELFNTLSGHELTFEQIVTFRLVHFGKDLYRKYYTQTLWQGLDRLPSPTEVLQSLHTQADQTSAPKPVAMVASPIATADKSTAPPFSPCHHCGGPHWNRKCPDNKAGSKGKKTKAPSAPSASLVTAPDISTLVDGPVLGYLTATMSTLARPSIILDSGATHHIVNDRACFTSFRKCKPAPLEGITGEVVNSIEGVGSAIVRSFDGSIGQLNDALFVPTAPVNLFSASRADIGGYDIRLTQAKATVSIADTVCHTGKLKNGLYHMQASLVDVAALVHQAGAFPRALVAVPMSVLHGRFAHLHPRALRQLISTEAVSGVSMEVDSNEDLKCDSCQAGKITHHPFPAVASNRSAQPLERVHMDLLAFDGAVSLGGARYALVIVDDHSRYLWVIPMSHKSDTFAAFKSWLAKVERSTSRKVLAVRSDNGGEFMSNKFSRFLEEQGITRQLSIPDTPQQNGVAERANCSITEGVRSMLHQLGLPHALWAEALATYVYVKNRLPHSANSGTTPHTRWYSSKPSAGHLRVFGCRAWKAATTEPRSKLDPRGIPLVFVGYDLESKVYRLLDPNTRQVFKSCSVTFFEDDFPARATGIRAPPLPAAGDDDSGVIIIPPEHVDPPAALRFDTPGPAWQPPAGPRARNPPARYGALASLRSTPSAFAFSLGDEVVALVANLAEAGIDVSKADRPLSEPKDPFMLLKGTRLLSSLTGSESKLKGSNGVIRRRRKTTKRTKVKRRGGAAREGKHEAAELPTSDPSTWKEAMRHPHAEGWKAGAIEEFRSMKDDFKVFSVVDLASVPRAATILPSRHVFRTKRDKAGKMVSLKSRIVAQGCAQRAGDFDETFAPTAKFTSIRALVAHAASRGHHIIQADMDKAYLHGVLEEEIYMRVPTGIEGYDGKCLRLHRSIYGLKQAGRVWNDTINATLANLGYGRLACDECIYRCADVLGDHYIALYVDDLLFFGPDLGEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MBN3</accession>
    <name>A0A2X0MBN3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">BQ5605_C008g04976 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">BQ5605_C008g04976</name>
        <name evidence="15" type="ORF">BQ5605_C008G04976</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY78862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MBN3"/>
    <dbReference type="STRING" id="796604.A0A2X0MBN3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="456"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="804"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="882"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="248"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="334"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="114"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="155"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="250"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="270"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="295"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="335"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="351"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SGY78862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1053" mass="117812" checksum="A7EA8FC1F2F5727E" modified="2018-09-12" version="1">MSDSEMMTPSSAADSGANSPSTAPTLVRGATTSTIKRRSSGRTTRQVIITDMQDDQVMEQDDDDDDDDVQVLIPSTDLQHLGPLSHSARSSRDYAPVKGSRKSVAHAVMTADSIKAEDSDGDSEHVTPSRPTRRSLPRRRSSQAKGNARIVQIESESEDDDDFAMVQDNDDDDNNDDDEDAGGDMEQAYDVETATRLAKALQNGGSKKGKARYVDAEALGKNVASKLGRARNGSTSKQDQSFELVVAKSNKVTAKTKSATPVTENKRQLTRTNSTRSKRGVTSASIARKSKMIVDSSASSDGSDDASAFSPDSDEDEDEGMLTDDSLLRDLAGSEAEEGSDDDLPDAGGDDGIKRNEKSYKKQVKTAEEIAEKLSRPKIKPRKGHVFSKKEKKMMSQLSRYEKADAYLMANHPELVDCWPKLEAVPRTKVERAEQPAGLTQKLLPFQLEGLNWMVKQEQSIFGGGFLCDEMGMGKTIQTIALILSDFNTADRKRTLVLAPTVAIIQWSHEIAKFTEGMKVLVYHGAGRIKTVKEMEQYDIVLTSYAVMESTFRREQKGFMRKGNLMKEDSIVHKVNWHRVILDEAHNIKDRASNTAKGAFALKAKYRWCLSGTPLQNRVGELYSLIRFVGVSPHAYYFCKQCDCKSLHWLCNKGPCTECRHSGMQHVCWWNTEILKPIQYGGMHEGQGAKAFRKLSILLERLMLRRTKVERADDLGLPPRVVNVRRDYFTEEEEELYQSLFKDVKRKFNTYANEGTVLNNYSNIFTLITRMRQMADHPDLVLKSRTAMPVQHADSDKPEEILTCRICLDEAEDAVKTQCRHIFCRECVRQYIETATVHKPLCPVCNIPITIDLDQAAIEQDTTGRQGILSRLDPTKTRTSTKIEALLEELSKTRTEDHTLKTLIFSQFTTMLDLVARRLQLGGYKFVRIAGTMTPLARDNTIKAFTEDPECTVFLISLKAGGVALNLVEASRVILLDPWWNPAVELQAMDRTHRIGQHRPITITRLVIENSIESRILELQRKKENLAASALGDDTTAAGRLTPEDLRFLFSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MCX9</accession>
    <name>A0A2X0MCX9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C013g07354 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C013g07354</name>
        <name evidence="5" type="ORF">BQ5605_C013G07354</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MCX9"/>
    <dbReference type="STRING" id="796604.A0A2X0MCX9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000179">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.19, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015992474" evidence="3">
        <location>
            <begin position="23"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="4">
        <location>
            <begin position="28"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY15381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="386" mass="41137" checksum="AFC3EFD4E4687467" modified="2018-09-12" version="1">MLGLGPVSALLLAALKVSQVNAAYSLYKDYSGSSFFDDWTFYGKYDNLTHGDTIWVNQSASAQLAYVNSAGRAIIKVDNTSTVPYNGKRDSVRITTNTNFGIGSLWVFDAYHVPYGCSVWPALWSVGPNWPLNGEIDTFEGVNLQATNQYAIHTDTGCLVNSPPNAMTGNLTYTNCSAYSNYNEGCTISDPRATSYGADFAANGGGVWATELASTGIKIWFFPRASVPSDLLVTNKNAQPDPSGWGLPAANYPSQPSCDISTYFGPQQLTIDITLCGDWAGQAAVYSQTCTLKQSCYLDSVLNPSTYNTAYFELDSVRVYNDGSPEATSTPVKTNATFSPTTGGNAAASPSKPSSASRVLMEFGSHGVVASALAVILIAVGTVLVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MEP7</accession>
    <name>A0A2X0MEP7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C005g03379 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C005g03379</name>
        <name evidence="3" type="ORF">BQ5605_C005G03379</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY74740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MEP7"/>
    <dbReference type="STRING" id="796604.A0A2X0MEP7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029523">
        <property type="entry name" value="INO80B/Ies2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006880">
        <property type="entry name" value="INO80B_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21561">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21561:SF12">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04795">
        <property type="entry name" value="PAPA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01406">
        <property type="entry name" value="PAPA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INO80 complex subunit B-like conserved region" evidence="2">
        <location>
            <begin position="303"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY74740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="446" mass="47514" checksum="D2622EDAF5301AA9" modified="2018-09-12" version="1">MPPRIRSLTPESDDDDDVSMMTSSSPQRKPTTPAAAPPTRPPVASTVPATSAATAGTTLPQTRDDDDDDLSSLQSSEEEDEEEEEDDVEDDEDKQVSRATSRSRKTVPQYKDDDEASTSSEEEDQLDDDDDDDGQDGAAYSDDDEEDELFDEEEEEFARARNAAGGSRSRASSAIKSSPAKATGAGMKIKFKLGGGAGASASASPSGGRTTFSSGGGGKAKKGGSSSKSSKSKGKKRAHDDISDISDDDAGDPSFSDGSSVNSGSRLTARQRAKEMGGEHGMELESLSNDIIPRNKVKLTDAEAALRRSENLRKRRSQAYKKLDDEKTETINRLLKKQVGRQNNRGGKASAKNAGQPNNLSHADAVGPRTPGATLEAARPPTGLRWVSSIKTGEFKNVLMLPVEIVEGFEGEPKVFKGYPGPRPPPQSRDLRQLDKTAPASVQPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MF91</accession>
    <name>A0A2X0MF91_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C038g11746 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C038g11746</name>
        <name evidence="6" type="ORF">BQ5605_C038G11746</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000061">
        <property type="protein sequence ID" value="SGY92547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MF91"/>
    <dbReference type="STRING" id="796604.A0A2X0MF91"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024738">
        <property type="entry name" value="Hfi1/Tada1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21277">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21277:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12767">
        <property type="entry name" value="SAGA-Tad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="154"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="380"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="188"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY92547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="452" mass="50113" checksum="E6B6EF24E78A23A8" modified="2018-09-12" version="1">MLVDPTRPLLQYLPRQRPPQLPQQHVLLLPHPPALLRSVTHPTASTSTSTSTSTSTLPPPTVPKRADLLSLKLKLADLLPPHLGQLYWTSLVEFMTGQINRDELQGVFERVLGKGKQGEQDTALQLHNALLLSILYNTTRIAVPRRRCAFRFPGQTKTRRTQRPSHNGSTSEVDPLRKKLKTLVMSLGKRERGDQGSRAYSDRRDGHRGLDDECRRSAATTGPSAVAGHQGSGWVVPSALAKRELERERERKRDKELVRLSTLAAALESGKGGGSRRDWRVERVARPILPSRKNTNASSPRRRPRLAASVRLPSCCRRRWVAGSMTLIVFESGLVGGGVVDERVGLLGVQASSTVDRDRGIRTSSITKEQLAIFDAARPVRREVREDDPPAGEGDVKAEQSFDPVKAVGLLNPPLEHVHVDEEDDDEEQRPLTTTISSACSTSTRRSWSYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MGM9</accession>
    <name>A0A2X0MGM9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C034g11331 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C034g11331</name>
        <name evidence="1" type="ORF">BQ5605_C034G11331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000065">
        <property type="protein sequence ID" value="SGZ00206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MGM9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ00206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="128" mass="14623" checksum="42D837A211E4DFE2" modified="2018-09-12" version="1">MAAQDFDEPGRFDRIDGKRIFDYMQFIGSPRVETKLYYSANTIKLHLTMVNRLKARQEAARGVPEPSTDELHWSKTTLKVLNQLYKPGRLSVALLMILAHSCTFDSDPDNDVLKTTPAEHGIYTLKDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MH34</accession>
    <name>A0A2X0MH34_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C009g05633 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C009g05633</name>
        <name evidence="5" type="ORF">BQ5605_C009G05633</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY83388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MH34"/>
    <dbReference type="STRING" id="796604.A0A2X0MH34"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092:SF2">
        <property type="entry name" value="HERCYNYLCYSTEINE SULFOXIDE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092">
        <property type="entry name" value="L-CYSTEINE DESULFHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-glutamylcyclotransferase AIG2-like" evidence="4">
        <location>
            <begin position="6"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class V" evidence="3">
        <location>
            <begin position="210"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="608"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY83388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="628" mass="70461" checksum="5120D4E1B7C57418" modified="2018-09-12" version="1">MATHDLFFYGTLVHPKILARVTGHSGANLTTCEALLPNHTRHHVIGEDYPAVVSLSLGRAIIGRELTAEDSRVQGSLVRGLTDQDIAYLDEFEGDEYVRTQVQVVPSLDPSVTPVHAETYIWIAPASRLTPSLWNFQDFLQQSAHRWVGETGKSNEYYGEVDRRRAMGGHITPKETEGHEYEQFGTAIGKKWWNFQEGYLNLNHGSYGVAPRPVIDSFRAYQDESNSNPDRFMRMTYTPELFRLRGRLSELVNCDTSDIVMVANVTSGVNTVLRSLTTQWQKGDKLLYFSTTIYNACSASLQWIVDSHPHLSLSLLPVPVTYPLSHASLISILKSTISTANKEGGGKIRLALFDAISSNPGVVVPWREIVSVCQKEGILSLVDAAHEIGQMPVDLRTSKPDFWVSNCHKWLMCHRGAAVLYVDKKHQPLIHSIPTGHYYRTSPMTPQDFQNEFDWNGTIDCSAFLSVHAVLDFRRNICGGEERITKYCHQLAVEGGEVVAKGLGTEVMQNQDLEKDGDLIANMVNVRLPLNDSTDSSLTDSEHHALLIKKLTWIHQQQLVDGLTYVPAFIHNKKPWIRLSAQVYNGLSEFEAIVPLLKGLCERVNKGDWEEKDPEEVAKEEGVDLVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MI82</accession>
    <name>A0A2X0MI82_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C011g06427 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C011g06427</name>
        <name evidence="2" type="ORF">BQ5605_C011G06427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MI82"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY12208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="94" mass="10769" checksum="DB8D4E5351277A2A" modified="2018-09-12" version="1">MRPTVLLCVRPIPLSSIPPLLLRLPPQSSPTSHQAERRRLKQASPTMEALVKKLAQRAAPLDNLRLHAYVPKRKEWEGVASKHRVLLQRLRREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIS3</accession>
    <name>A0A2X0MIS3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C018g08772 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C018g08772</name>
        <name evidence="1" type="ORF">BQ5605_C018G08772</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY26753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIS3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY26753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="296" mass="32865" checksum="ACE57FBB1B014546" modified="2018-09-12" version="1">MTGSLNYRATAKDHCVYVQCDGDRHHYIALYVGIKRLGPAKYILGIQIKRQANKSIILSQEAYITSTLRRFGITRYMQAIGCILYAATGTRPDISYAVGYLARFSASPTPKHWTEIKTIFRYLRGTASLGLHYSSEQGKFSGFTGYSDADWGTCTTSSWSTMGYSFHLAGSVISWSSKVQNRVADSTTDAKYLALSHASKEAGHLQELLMELGIDTRAPVQLYGDNQGAIALAKNPTLHHRSHHIRICEHFVCDQVRLGTIQVDYVDTKSMVTDIFTKALGPLVFKVHSDNLGLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJ28</accession>
    <name>A0A2X0MJ28_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C029g10623 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C029g10623</name>
        <name evidence="2" type="ORF">BQ5605_C029G10623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ14844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJ28"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ14844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="287" mass="32447" checksum="ACDFFED091851E0F" modified="2018-09-12" version="1">MSSSTHIDATLAASIDERIHLEVQRRLREFTLSPVPVSDRESLPNIDIPRHLSRWPADALLSGVKTFSVWDRTLQDRVGATIYEFITTGNLPDRASTIDRENVETFAVQQVSDGVASNVRKSLLTVVSRHQRARAYYEHLNREYNPKSSQSTFQLLHSFFGIPRAPIEEKGFVEWMTEFLDRSNCLESAQITITDVITARGRTLLPDGLDAFRQHMELHNNNKILTPANLMALAHQQVKVHHGTCNVSQRTKIGGMSRTKGRGTRDKSRDVLGTSQERRGRGMSARM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJE4</accession>
    <name>A0A2X0MJE4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C034g11330 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C034g11330</name>
        <name evidence="2" type="ORF">BQ5605_C034G11330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000065">
        <property type="protein sequence ID" value="SGZ00198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJE4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ00198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="157" mass="17252" checksum="6171972D6C0D99D0" modified="2018-09-12" version="1">MLQASSWPSPPRREAEAHCAPVSCSSGQTSGQGGVYTFKVDRSNFGGLFEGAENIPASYRRCETTSSHSNPAGATFARISSAATALEEADPHRLLTVGTSKPRVIREWIARFKRFGTRSTLHAFYLEDILSMHKFTGSGSRRYAVDPRRRCPTNAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJF0</accession>
    <name>A0A2X0MJF0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C010g05974 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C010g05974</name>
        <name evidence="2" type="ORF">BQ5605_C010G05974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJF0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36986">
        <property type="entry name" value="UPF0643 PROTEIN PB2B2.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36986:SF1">
        <property type="entry name" value="UPF0643 PROTEIN PB2B2.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY13781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="307" mass="33839" checksum="51FED58393061D90" modified="2018-09-12" version="1">MPGPTLQQCPAASASFPVGESRNTSTNFGPFALSTIPPARRIEATGCPFSLNTESEPKSAFADLRCPISGTPARTSALKRGGSTSTSRSRAPTGFPDLRRTPSAELLYLPPLLSLLPPTTEKNALKDITNTRVGYYTRSHLPSIDEASIALHHALHAFQPKTDQYAYEPYDEAFNFDEIKLPVHLEREWYIVAFRSTRAKDSPSRNLYEADRQAHEEAVTAGGLLAYWFGVPNSRGSNLATCIWMSRAHAVRAIAGPKHVEAMRLAEAMYANYDLERYVLRKAKGVVGVTIEPWRGGEIHFGGDYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MK96</accession>
    <name>A0A2X0MK96_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C021g09320 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C021g09320</name>
        <name evidence="4" type="ORF">BQ5605_C021G09320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000083">
        <property type="protein sequence ID" value="SGZ21002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MK96"/>
    <dbReference type="STRING" id="796604.A0A2X0MK96"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ21002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="388" mass="42940" checksum="35D9AAEF6C810FAA" modified="2018-09-12" version="1">MRTAKIVAVDDITFQLDKVPFSLPVAALIALLSFHRQRQILGPQLRFLDHVRSTRWLKWFLTFVVIKSANRFLGRMARNNGYYAADPPRWSRVKGKGDVVLITGGSTGIGKEVVELLVKQTNKIVVFDMAEPTYNAASGVHFFKVDITDPEAIAVAAQKVRAEVGHPTIILAVAELLTTILPVQVNNAGIIHVAPLLKATPASMKKVFAVNVMGAHNILREFLPHLIAINHGHVLTTASSAAYASVCEFAAYSCSKAAVLALHETTQAELFHRYKAPKVRVSIICPTKVATTLGEFLEDKSLQFLFPTISPKWLADKMTTTIESGLSEHLVLPHYASLLPGLRFFPEWFRWVFENAGSVHSMTSEARTANTSSKIYTFAKTNFDDRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLQ7</accession>
    <name>A0A2X0MLQ7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C024g09828 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C024g09828</name>
        <name evidence="4" type="ORF">BQ5605_C024G09828</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ26069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MLQ7"/>
    <dbReference type="STRING" id="796604.A0A2X0MLQ7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180022">
        <property type="term" value="C:RQC-trigger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009349">
        <property type="entry name" value="TRIP4/RQT4_C2HC5_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06221">
        <property type="entry name" value="zf-C2HC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRIP4/RQT4 C2HC5-type zinc finger" evidence="3">
        <location>
            <begin position="240"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="135"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="509"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="173"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ26069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="551" mass="58903" checksum="675776FA8E203053" modified="2018-09-12" version="1">MTAASIAASLAQLIGLGESFYPPFSAAYHEPTVAQQILPYMTSIKTAQQVSNYLETLLPPGQASRALIEAYLAQRFPAPAASRPQPPRSSSTAAKADPWGTAKPTPAAAPTRAPNMAAMQSQFASTGKVYVKNRDDLDQGRRGGGGTASSSRANSSSRAPSGTTTPVPPPMAPSSSSSSSVATRSSKPPFHHHINDMSSLPTPQSISLSETGRSQLATLDTSLKLLRLRPSSSSSSSPSKRACFCSARYHPLSPYSPICPSCGLVLCSLNPPSFSCPSCQHPHLISAPLLESHINTLETQRSEMLERERRRTEAEKEQEALERAAIRFPELGGGDRAHVAQGAGSGRMGYAGLVGGGKVDIQARIDRGYAQGRTVGGREFGGGGAGGGGAPQRVLRLDMKTSKVKVQTKTKVVKKSEPKLDRGKAEYLEKEEEVDEWESSRWIDESDDGWRLRKGLSPLDHTTTTQADRDATRPFLNLTMDEKDQPLWIEPLTIDSEPLPSTIGVDIDLEANTGRRNVPGAAPSKVLEGKKNKRSRRAKTEEATPSSAVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MM44</accession>
    <name>A0A2X0MM44_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C024g09945 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C024g09945</name>
        <name evidence="3" type="ORF">BQ5605_C024G09945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ26582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MM44"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF118">
        <property type="entry name" value="BETA-1,2-XYLOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="2">
        <location>
            <begin position="369"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ26582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="647" mass="74367" checksum="002D1A6C16DFC52D" modified="2018-09-12" version="1">MNGIRPGEDPTRPSRSSWSHPIRRCSDPRGGGLSYRSYGPREGPLLSTEILDHLDARFNFNIATVTGQASIGAHNVLTHAGVSLPDALPDRIHDFIETWANRADDGSKDLVYTPHLSPGPEDDDSTWTVTTPHEFNSNGHLIVEPVSTFGKAPPAPHPILTLIQRAEHEWNNRVQRQSKTLREAVYEYRKRYRRNPPKGFDEWWAYAKANRIVLTDEYDQIFKDLQPFWALEPHDLKHRVLVMQEREETFTIQVKTARCSRELIARVSKHVPNVNLTFTRHDQPACQLGWFHKERMLELAGEGERGSLSLRLWTLEFIAESDLPLTNWANGCPPDSPLRKIETRSSKLLVSRPTRPPSRPSFERAYATELSQKRSYIYDYSSALDICQHPEIMPLHGFTTAIGTTQGHLSLSSPSPKPISTLISSSHLSSKYNKLMWRGSTTGAEFAVGYDWRSSQRARLHFLTNDLKGQKNVLISEEEGPIKEEMMQMHNLNKAQCDVSFSGGPVQCDDETCAIMKEEIEFRPTMGLTDSYKYKYVFDVDGNGWSGRFHRLMSMKACVFKSTLFPEWYGDRIQPWVHYVPIKVDYSDLYDALTFFRGLQGKEWARDHWRKQDMAAYMFRLTLEWARIVHRADENVDPASLDFEFFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MMC4</accession>
    <name>A0A2X0MMC4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C015g07714 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C015g07714</name>
        <name evidence="3" type="ORF">BQ5605_C015G07714</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1088"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1674"/>
            <end position="1694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="456"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY17224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1937" mass="212691" checksum="199C370D0EBA96B2" modified="2018-09-12" version="1">MPDPPGPPPHPPNAPWAGDVLRDESLNTETRETVTGGTVNPPAWSAQASQARLDHEKSMQKAFKALGIVPSSKSTRRLMVLLYDPSSPPSQAPALARAAQRAVRNDAMPASNVIRVIMDGTGSPRGPVQIALRKHFGLAETPFMFARPEGAELDPEVEKLFSKCVKLNPIVTKATKRFPIARHMYELVFESDQACLEAAAAGPFPYHGKEMVTELPSVSPLNHIVQVRFTLPSSSSAIPASVLRKSLDAALTSSFGHAGCTQGYTLMQLQRGLAVDPNGDPMAMTEDGFHCAYLRLHADLFQGSTETQKAALNAALPQEIEILGAKYGLRHEFETHYCAVCDRAGHQWGACRKPVSTPATAAPVPGASTSTSTSTTGFRVAGKNGKHGGPAALNSRASGTNMIQLGPRANPASAATGNKDDANDGDGDDDDDDGESVASTEPEGGDAGKETLTRATTGPTKETQTKTAAPVSTPTSPSPSTSAPASPLSGGTSESSATSTTSIASTSPRRLRSSSAPGNRRVTRAGSAMIHGASGGDDSGGNSSGGYRSESLTVLTFNVRSIKNAVNQVKIIRYLKTLRPAPAAILLQEHHLSYNALREGFESAWPGACIRFAPHVLTLIPDGSPLAGRLLSSTPVVFAEAPQFDGRILRSVFRLEELDIEIINMYAPVKGEERRDFYGLLHFTAPGPKTLRILAGDLNDCPDVSVDRVAITDRAWTPVSHWQTLLSKIAFNPLDTIRQLHPITPAFTRPHYLGRGDKREICSWSRIDYILVQRSWANRLLSASTLFDAPCSDHRPVVATFALPTSNAADAEPPPALPTTSEFISRLNPTVFNDQDFVDSIPGVVDEVYRRLEGTAPLGDVYDAALRAVAAAGHARYRSTRADMRRLRAENQSVMEALEARGEHMNEAERDAYALAKSQLDQLAVKEAQWLRIRAHVPSVDSREGQSASIRTRLNRRSRQTSIVSLEDVDGTETVDMQEALGIASRHAQSLFMPDPARGDPTNARRSLLDPIRASKCYDDDRSDPTFGRRLPLQARVALDEPFNLSEVEAALKKTDSGRSPGPSGIPYELFKALPTYFAPKLLDLFNSIWEGGKMTASLAEGLVRLLPKNKPGANLKSLGAYRPITLRETTYKVLSKVLVARLNGVLGELLPPAQHGFMPSRRSADAGSHLTLLLEKLKSLGTEVFPEGALLSLDQQSAYDRVDHAWIFDVFEAFGFGERFISLLRALYDPETLGVRYLINGFPTELVRLLCGLGQGDPLSCPVWNITFQPFLDALVRRGIALDLQKVWPGGPRAQLTHLAFADDAVVVVESPAALSKLETLSQTWYEATNGKTNTDKTLVLPLGPNWLRDETAQALPTVQEGESFKWCGYAFFRHGDSKLFWTHVLDRIKAKARAARDRTLSPSGRVFYANAHITSTVLHVLSFDIPPQRFIQAAETALTDFVWGGPRRNTVARDFVFQAREDGGLGLISIGDIVHSVALRFWDAVAGSDEAIWAPLARESWRSLVAATRDFSPWGFFSSTARVEKLYRDSARWGAVVAAARVTLPTIKSELLTLPELLSLPPRLPSLYAEGAKHAYDDADAVAKFAQIADLYWRDEGKGWALVGHRRGFWQHSKEPALRHEHVWARVGQKLKAKALLPKTAVRPARIPLKEAPRPRCFNFFGLTRPFTIRKLPLPGGQPQEPRVKRFPEGTSQSGRQRFWSWLHDRFASAAEQDTHWRLMYDVTPTRKKQHVQGHASSPSCLFCGNDAAVIETVSHYFFGCAYSASYWSGVLRILFDKLGIEDTDVDPSTFTQEQLTMGLPLLRGRGRTTSKWMWVRLACAIGFQRLHLLRWHVHQRFEKDRVVAPPSIPSALRAFNRDYLSRAGFVPGARDWEPPSPFPSKPLDGSRRMEWSLRRGSEEGSFVLLDRFCRLPTAQQPALETQPRRDIRRCRGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MMG2</accession>
    <name>A0A2X0MMG2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C025g10056 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C025g10056</name>
        <name evidence="2" type="ORF">BQ5605_C025G10056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000087">
        <property type="protein sequence ID" value="SGZ27105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MMG2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ27105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="275" mass="30341" checksum="6105A016FD71B8E8" modified="2018-09-12" version="1">MVRAFEAKPVKLGVIHNDVSAGNVLLRPNDGGFCLIDWGRAYLDLRSSLLCALVASLSPLNFCCFMKCMHFTLFYLRYLLAERERALQSQVRWQPTLAGGPSAPAIFSALTRYGVCHSLGAFFISNALCCMSSPSAATVNTDALSQFNALLSSCAPFDWFDAPACHSTAPRQMSRRGTTSLRCGVWLEDLEWSDKSSPASRAVASFHRLLERHHSLLDLFRAKMADLDSGASTTFRDLRRTSEADASDAFVLLFNNLLKSATEHLLDHYDAETAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNV3</accession>
    <name>A0A2X0MNV3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g02447 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g02447</name>
        <name evidence="2" type="ORF">BQ5605_C003G02447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY40938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MNV3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY40938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="141" mass="14873" checksum="1227892C662DE55A" modified="2018-09-12" version="1">MHAQLVVGDHLDQPLFLLRRSSLPGSSSSSLFKSKHLLHPQLHDDPRRPRMAAVMMRAIGVKSPSSSSLNGAAEGGSGSSTSTATGEQWDGQSLARQTSRLSPPNPALIPGQKMGILIKSVLFISCDLPMVCCSLGPGVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPN4</accession>
    <name>A0A2X0MPN4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C022g09529 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C022g09529</name>
        <name evidence="1" type="ORF">BQ5605_C022G09529</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MPN4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ22705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="122" mass="13208" checksum="31958341B1D16ED2" modified="2018-09-12" version="1">MVYADRAWIYSARTLASSTQLTALLTPPSHHPAPSGRPASKLVSILSAFSVLPLIDLLGQLLHSHSFQLRKSTCWNGLVQQKTISSVSTMGANWVEAVIASESEARDSWAQYSLESVQLGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQ19</accession>
    <name>A0A2X0MQ19_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="23">BQ5605_C044g12127 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">BQ5605_C044g12127</name>
        <name evidence="23" type="ORF">BQ5605_C044G12127</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000114">
        <property type="protein sequence ID" value="SGZ31288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQ19"/>
    <dbReference type="STRING" id="796604.A0A2X0MQ19"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:endonuclease activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:peptidase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
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        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="14" id="KW-0229">DNA integration</keyword>
    <keyword evidence="18" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="16" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="17" id="KW-0917">Virion maturation</keyword>
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            <end position="280"/>
        </location>
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        </location>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00048173"/>
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            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
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        </source>
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    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="SGZ31288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="342" mass="37150" checksum="63B7BA6C13C5B84C" modified="2018-09-12" version="1">MVADRSLFTTYRPTAHTKIGGIAGGITAIGMGDVPFVANTGHPITLRGVLHAPGLHVNLLSVSRLCDTDRVRLAFTSDSIDITEDGQAIAHSTRVNDGLYLLDADHTKCQQLAFLSRSESTVPLITLHRCLGHLAPSSIQKMIAAGLLDGFGAGYSDKDVEEFVCNACLGSKGHRLPFPDSESHSPERLGLVHSDVLSFPTPSLTGKRYLVTFLDDHSRKLWAYAIDHKSDVFPTFQTWLAEVELETDARLRILRTDNGGEYRSNAFTEFCQSRGIRYETITTTVRREVVRGKLRNRKGARTGIGPAAGEIARALRQLRASKSPPQGGGLAGARPSPLAPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQ48</accession>
    <name>A0A2X0MQ48_9BASI</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="2" type="primary">BQ5605_C023g09711</name>
        <name evidence="2" type="ORF">BQ5605_C023G09711</name>
    </gene>
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        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ24187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
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            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SGZ24187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="417" mass="45610" checksum="D8D4BD912F447590" modified="2018-09-12" version="1">MTEQPPGHLIPSQHLPTLSPHPPPSQLRTSLDRLQRLVAPHQIIIDLRSTSSGLQPSLNQDLATLDAFELNYARQWLERLVSLGSRRLVLVEDEEEAAEWEGLVEGGSYVLGRLMGGSASGGSEQVFLLPSPLGQEFEPLRIRIRETTLLSNSTGFRTWASATLLAQRIASNPFDYLPTTTATTTTTISDSEPVAAVQILELGSGTGLVGLTLIATLSVLGIRSEVDLTDHEDSVLENLRRNLDRFSREGLDEEAVVGGRVSKLDWSDHPSDSGSIRCHTKEEGRKVFDLIVAADVIYEPDHVELIHSTVAAFLRQPDPRSTRFEEGGTFHLALPLRSTHGLEMETFKKTFPRVSSERNGRKESGGGGGGGAWRLAIGDEKLIRAENGDDGLGSGNGVQEYRLVRIRWALGEEMEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQE2</accession>
    <name>A0A2X0MQE2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C042g12016 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C042g12016</name>
        <name evidence="2" type="ORF">BQ5605_C042G12016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000116">
        <property type="protein sequence ID" value="SGZ31836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQE2"/>
    <dbReference type="Proteomes" id="UP000249464">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ31836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="274" mass="29368" checksum="5AAFB13119F52306" modified="2018-09-12" version="1">MASVLHLPPSPSATSCNNKWTGSPRHRSGTTSTLPRPGLRRNTSTSSIILSPVLRFSPNSIFIPSPSESIFSFGEVSYVDHSNVSPTAPVASSACSGNQESRCSFAPDTKPQRPTIITKSPKSTGFVPLNENPAKSERSQRIPTTISPTSATTPTAGSSLLARRRSSVASGKRPDIFALSDLKISPPLEQVLDDTVPFKVIGMASAAVTPSKEDLGLAKTPTLVVKSFRPTKSFVPTPFPEKRQFISDDEGDSDRKDDELEEREDGKVSDVAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQF2</accession>
    <name>A0A2X0MQF2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C026g10156 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C026g10156</name>
        <name evidence="2" type="ORF">BQ5605_C026G10156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ27654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQF2"/>
    <dbReference type="STRING" id="796604.A0A2X0MQF2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ27654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="284" mass="29210" checksum="1FCABEAFC321278A" modified="2018-09-12" version="1">MSYQPDYQTDQKQGGYGGGGPPGAEGDHRPLPEGWIAQFDQAHSRSFWVDTKATPPRSIWTHPLDDPTYLETQRSQTSYAPPPGPPPPSSNAVNNRDHGPYTQQQYGQQTQYAQQGYGQASPIPLTTPIGAGAGAGAGAGAGAGAGFANSPPPPQQKKGGLGGLFSKFSGGGKTQQQQQAYYPQQAYAQQQQAYYPQQQGGYMGGQGGRMGGGMMGGGGRTGGGMNPMMMMGGGLLAGGLLGAGLSNMDNNHDEQEAYQDGYQDGGGGDDFGGGGDDFGGGGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-11-27" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQL5</accession>
    <name>A0A2X0MQL5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prephenate dehydrogenase [NADP(+)]</fullName>
            <shortName evidence="2">PRDH</shortName>
            <ecNumber evidence="2">1.3.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C042g12023</name>
        <name evidence="4" type="ORF">BQ5605_C042G12023</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>prephenate + NADP(+) = 3-(4-hydroxyphenyl)pyruvate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21640"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="ChEBI" id="CHEBI:36242"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-hydroxyphenyl)pyruvate from prephenate (NADP(+) route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prephenate/arogenate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.13" evidence="2"/>
    <dbReference type="EMBL" id="FQNC01000116">
        <property type="protein sequence ID" value="SGZ31864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQL5"/>
    <dbReference type="STRING" id="796604.A0A2X0MQL5"/>
    <dbReference type="UniPathway" id="UPA00122">
        <property type="reaction ID" value="UER00962"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3660.10:FF:000004">
        <property type="entry name" value="Prephenate dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3660.10">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050812">
        <property type="entry name" value="Preph/Arog_dehydrog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012385">
        <property type="entry name" value="Prephenate_DH_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21363">
        <property type="entry name" value="PREPHENATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21363:SF0">
        <property type="entry name" value="PREPHENATE DEHYDROGENASE [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036510">
        <property type="entry name" value="PDH_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0827">Tyrosine biosynthesis</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="3">
        <location>
            <begin position="10"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR036510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ31864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="456" mass="50726" checksum="CE31526D8467A58C" modified="2018-09-12" version="1">MAANTQSSRPIIGLIGMGEMGKMYAEALSKAGGSTVLDGRRIHVCDLPSKYYQLVEYCKGKPGLVPMVDGHHVSRSSDFIVYSVEAEYLDAVVKQYGPSTKMGAIVAGQTSVKAPERAAFDKHLPSDVKIVSIHSLHGPTVSPEGQALIIIQHRASQAEVRIVEQILAPLKSRYVHLTYDEHDEVTANTQAVTHAAFLTMGTAWRCMQSFPWETGRYIGGIEVVKINIALRIYAAKWHVYAGLAILNPTAKKQIKQYAQSVSELFKLMIIGKEDELRERVFAARDYVFTRDADGNSPAPILLSDKALDKFEIGAPEASPAPRANSHLSLLAMVDCWHALKIRPFDHLAIGATPVFRFWIGVAEYLFRSEERLEHAIHSAVNDITHRSDDAEFLVAARGWSECVGYGNFEAYRLRFEETAKFFEPRFEESRKQNAAMFKFLAEEPVRAAQGKVEPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQT0</accession>
    <name>A0A2X0MQT0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C019g08861 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C019g08861</name>
        <name evidence="5" type="ORF">BQ5605_C019G08861</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY22813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MQT0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039226">
        <property type="entry name" value="Ski3/TTC37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040962">
        <property type="entry name" value="TPR_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704">
        <property type="entry name" value="SUPERKILLER 3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704:SF7">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18833">
        <property type="entry name" value="TPR_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="39"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="736"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="770"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="1059"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="1232"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="587"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="587"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY22813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1538" mass="170326" checksum="5AF87EC77D70E659" modified="2018-09-12" version="1">MSALIKDKLKLLKTAVQAKDWTNVEKHASIVLSFEPSNYNARVFLALACTNLERFDQAQEEYQKAIELAPSQFLARQGLASLYEKQQRWTDYAAALDQLVQQAQEAQDGPKCAESLAKLIQVRRTHGTTAELAQVLSLLLPSSPLYPILQTLPPPQPTNPTATTYHSIQMALFSPLPTLLELLSLTEAQETNLIESEIKKRRQRLGGPSLSASETRKLVEREYMLSSKLPDLYKVILEDPDASEREELRRQVEGKLLRHWQTLLFALPSSFDEASLDLSISKLGETGKGKVSDVAGRKEEDDRVKNSVRWEIEQLTKGMVLIEVEDELAWKVQLDWGDRFGNWEEIDWRLLNKFKDKFPDTGLAAVISVAHRYHLAHLEASTIPDDLDKNDEDKIVAPSAEESAEVAESGLEKSNDLMLAHLLLIRYFSDQEDYATVVSLGEGGLHLLRKREAEIGRALPSSRTTLETHLAIALVHHSSPTHHVKALRLLDSLLGRAKQNGAVVLSDLLVAKALVYQSSEKWLEAVDLWNQVLSFSTLTENVRITAQSERGWSLFNAKQFDAARVGLHDAVIALEARYQLRLEQQRRNETARSKAGVEKPPGLEEGESSREAEERAKALWRLGECDWVLSEEDESLTLRAFQAYLDSIKACPDFAPTWTSLGIYYRSIEPPDWSRSLKCFQRAFELDQSQEVAARYMAEEFAEIGDWGLVEKVARRVVEAAAAKAAVGVSTAKKLAWAYKAIGGSEMNSQKYPQAIVAFQTALRGEPEDVHTWLRLGAAYRGSGKHVAALKVFSKVLSIDSDNWFAKFSIGGVQREMGLFEPALTTFKDLLVERPDELGVQVVYAETLLSAGMEQLRTGFLSRAEESFVETLEQAIRVIETGGAKRVAWKLAGEASSNLVKISECAHFERSKGLAIQLVKLAGEMDVDTKVDGIDIVTVAAFLDVAQSSESPILFAGVAVLAHKARVVLDTHNEAAIGSAWADLGTSVANLRPYLSKLSPRFTPETALHQAIRALKFGLHHEPFNSSFWNALGVLTFDISGRLAQHCFIRSIEHNSQNAIAWTNLGLFYLVYNDDDLANQAFLKAQVIDPEWAAAWIGQATLADMAGHALEASVLLEHAFTLGADTSEADIAFASHALEKYRRSTSVDPDLVADRFDPARPDAAKNLTAPLFAITRYLTRRPNDVSALHVNALILEHLGDRKAASESFERAAALLEELYEEDESASVEGRFIIAQTNLGRVRLASENYEDALEAFDAALSLIDLEARPTEKDALTQDQAVILFSHCKLGSALAHYFLEETSMAEQTLEEANDDLDSYKNDRTVHLAAALARIYFAGGDETRALGALLDSPDITKSSVPLFIKLTLEALSIITRTPALDEMLSRMKRSDPIIKYSPASTKLTALGRLIQGDVHGAVRLTSRVLHVAPWTRPNRARLARLLTDFPTALSDPKHSTTVPSPTIAIPVVLRLLPPIPPTAQVEGIRALQSLGMSGLAFALNEDVDKASRGVEKALHFGPWLVQMQRAIRTVIKFSARAVESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQZ2</accession>
    <name>A0A2X0MQZ2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C025g10004 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C025g10004</name>
        <name evidence="1" type="ORF">BQ5605_C025G10004</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000087">
        <property type="protein sequence ID" value="SGZ26942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQZ2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ26942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="218" mass="25009" checksum="BF289CA7DDC42D0A" modified="2018-09-12" version="1">MRTMFSTSYSRFYRFSSISAFTIATCRSATFCTIEGISFWSIGTRPLLHPGMSPSRICVADDRSEESVRVTLTTTPFSVLLWILKEGWMDLPSHILVKDLESATYWFMLVLGAFREESTGTGVWRALCLAPMRAQPSLGFLASRLNLWSNYVQDQRKCNQLLEAVRELDPAEGKVVDIFARFFPTWGLLLDHLERTKALMEDMQNKMREYLGLQLHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MT35</accession>
    <name>A0A2X0MT35_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C002g01277 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C002g01277</name>
        <name evidence="3" type="ORF">BQ5605_C002G01277</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY31920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MT35"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="2">
        <location>
            <begin position="347"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY31920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="515" mass="58203" checksum="D75E1E5A1D43293D" modified="2018-09-12" version="1">MAVCAYCMARHWECKGRTGHRSTCCSQGKVRLPPPLRHNPECRQLREGSDSDAKAFRENARSYNNALSFTSLAAHWDQTQVGTLGPPVFRVFGRLYHRLGALIPAVNQRPAFAQTWLIDPAEATDTRLQGPDSAETRIQRSTLTKLESMLRTGNRFVREFASAKARAGWDTAKEWVLRLCLPPGRDRRTHNLPTSSTEMAMIICDSDINTGDRGPQDLILQVHGDRCPGVRPKYQIVSSLHPSAMPLRYPLLFPAGEDGFHPNIPLCEFHQAGPPIARNREQIDNGVQLRELLAGLGLDDEDEEEDEDRDDEDEDGEEGDEENGDDERKRLPLFLICSFLLRRNEEHLAYYLHEHGDYFSIPHATQRLFLEFVIDGYSQLETDRLNYIRFHQENLRLTTAQGITDAVANGLTPDQIGRSVILGSTFKNSPREVTQRYQDAMACVVKYGKPSLFITVTCNPEWPKSRLHWGRTTKHTTVRISLHECSKPSPATSNGQAVSVMNGFCFFAVLRIVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MTN8</accession>
    <name>A0A2X0MTN8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C043g12100 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C043g12100</name>
        <name evidence="3" type="ORF">BQ5605_C043G12100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000117">
        <property type="protein sequence ID" value="SGZ32166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MTN8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ32166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="258" mass="27768" checksum="EC613316F6AC7BB9" modified="2018-09-12" version="1">MSHLNVAMAVLIGLGMVVVGSFLLCSIMFVTTRHHSAIDRRLVAVENGLSVPSHLSSDDPSDPTLPHLRPPVDNMDAAPEVDAPSSTPYRQAEPEHPFQPQLPSEYLFARSRLYPSLSSSPSVLFQGCIPIPPSYDPNRRRLPSYEDVMGASAPAEVVVISETVVTTRRRSAVMLTGNRDEVTTTRRTTMVEQTGAGESGRTSGELSTDDYGQATDDDAESVKSADAPPGVDDEDDDDEDPIGELIRRGAATVIHLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MTP4</accession>
    <name>A0A2X0MTP4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C041g11928 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C041g11928</name>
        <name evidence="2" type="ORF">BQ5605_C041G11928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000119">
        <property type="protein sequence ID" value="SGZ33089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MTP4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ33089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="287" mass="31735" checksum="BCD5FC4E094514DE" modified="2018-09-12" version="1">MSDAGASAPEAKLREPTPDAPPLRPPTHSAAFATTELLRNSSGYRDWVLAIRSRLPSGVVRYLNTGVPLESWPASYVPLWDHYACSSICASVDSQTVLPGLSPYLDESLAAPKVWQALRERYGTVSAVDLLPVIQRLFSSDPVPVTPDLFLQFRDSFENDARLLQDSQVTVNALLASHLLARLPSSFDAWRTTFVADQGDSTAMPSATEIFTRLYRNVKARPVDTPVAAVATPQARHGCSRPCPNPSCRKLHWLRECPDTAWAAAYRARLSGKQRYTDSNTRRKSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MU77</accession>
    <name>A0A2X0MU77_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="10">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C040g11895</name>
        <name evidence="11" type="ORF">BQ5605_C040G11895</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the tannase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="10"/>
    <dbReference type="EMBL" id="FQNC01000118">
        <property type="protein sequence ID" value="SGZ32619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MU77"/>
    <dbReference type="STRING" id="796604.A0A2X0MU77"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF15">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015796350" description="Carboxylic ester hydrolase" evidence="10">
        <location>
            <begin position="36"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGZ32619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="609" mass="65447" checksum="2368EB0A5BA11DF3" modified="2018-09-12" version="1">MDPHRFDNQSCSALVLCPVCFLTAAAALCLTGVNALPRPEDSTARVAGTDFSTRCANMASVKMPGMTFYVTKHYDVNTTFSTPDSELTLSPSIASVDYNSPVAGLAAFCRFGAEIKTSSQSKVRFEVWMPDDWSGRFAMVGNGGDAGGVNYPDMGVPLTKYKFAVASTDAGHNGSIGDGTFAISNPQSQIDFGHRAVHLTATYSKKLIRTYYGGDGAKYNYWIGCSAGGRQGLKEIQLNADTFDGVLAGAGAHWFPHLNGQTYRLNAFVNKIGSTGYLTAANYATIGTEVLKQCDVLGQDKLKDGIITDPVSYLASSFLRKSKPLSSFLSFLLSQQTKCSPKLEGLLCSAKGANNRTCSSQAQIKTMYTIWADWKSSTGLSTGPGGTNYFPGFQPGSEGYSSAFSVTDTPFSPGPDYFNYQVLNKTSVQPFTVKSEADFEKLLKIADDTDPGQTNAINSDIRGFLSRGKLITYVGLADTLIPTGSSLLYHDRVKAKLGNVNDSFRLFAIPGMLHCSGGNGAFNIGQAGQRDISLQGAAQSASFTAKDDTILALIAWVEKNQAPDSLVGVNYVNGDKRQGVAFERLMCPWPQLGYYRDGDTTKASSFRCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MXL4</accession>
    <name>A0A2X0MXL4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C001g00394 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C001g00394</name>
        <name evidence="7" type="ORF">BQ5605_C001G00394</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY46172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MXL4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF10">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="440"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="477"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="534"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="18"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY46172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="568" mass="60326" checksum="CC0FE5372BA8A6DA" modified="2018-09-12" version="1">MSVDESSGRRDDVRDYLIMTAVSGTSFINSYFSGALTVSLPQVQKDLNIAASALQWPLTLYALVLGSTLLPMGRLADVYGPRSLFLIGRPHRDLFCLPAALYFVVSIAVALSPTMIGFSAFSSMLGICAAANTPSGIGILGRHFEPGPRKNIAFALLGAGQPLGFASGLVVGALLTETKLEWRASFYVQVALAALFGVLGFFVVPKIFAMDSAAIPLVTARSADVTLAATSDAASVASAAESAATSPPDLSQNRRIDWIGTLLSFAGFVLLTFALADASSEPLGWKTPWLPPLIPISVLLLIAFFYWEVRLQHMVIAFYSSPQEPKLGGKPKRPPPPPILPPGIWTTPYLPAILAVVFFAWGAFNTCTYYVNLVLQLVMKESALKTALFQLPLIVSGIIFNIIPGYAISYIHGNTLIIISMTLGIIAPILLAVVKPDHGYWAAIFPLLALAPATDLSYTVATIAISRSATRSQQATAGALFQVTTRLATSMSLAIISSIATLASDKYLAANPFAGDLSPNTTKSPDVLLAGYRIGGWLTFAFAAIALTISLFGLRGMGLVGSKEEKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MYL3</accession>
    <name>A0A2X0MYL3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C008g04905 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C008g04905</name>
        <name evidence="4" type="ORF">BQ5605_C008G04905</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY78639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MYL3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="Lysozyme-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016165661" evidence="2">
        <location>
            <begin position="23"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Transglycosylase SLT" evidence="3">
        <location>
            <begin position="319"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY78639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="458" mass="49477" checksum="36B8FBBE0A8F06D6" modified="2018-09-12" version="1">MHISALFYLLGAISTLISGVAAHPNLEWYQNRDLLGRQEVVQPSTLNVAATGAEDPHVSSPLRRRSCAAKARQRTAVAAKSNSAVRLQLASTKGASTHIRTTTKVPASRKKHTIASKHLRKSKAKTVKRPVQKHKHRTIRKTTPKKMTTTKKKTVSNKKKVTHKNKTTHKKTKKVATKKASGIKAKLDSKTGKSSSSGSGGTVFTSKSNGDGPGLFGVSTSQCGASGATEAITKSSGPNGAESWLNCGFSTSNPNSGWVRFVIACIVPRGLYRKLTVLYIFLMQNPPYIKISQLRARTMEEALAMPNSVFSACKPYVYLFEKYGSQLGLPPILLASIAMQESSCNAGTMGDHGGAWGLMQITSDKCGNAPNGNCADPDYNVGTGARYLKGLLDQQNGDVLVSLGMYNGWYRGLTYYGATKIRDSCFQCQNNGDYHQQLLNGWMQGIDGSQLGTIRNIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N061</accession>
    <name>A0A2X0N061_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C009g05456 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C009g05456</name>
        <name evidence="1" type="ORF">BQ5605_C009G05456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY81093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N061"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY81093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="99" mass="10679" checksum="D17EFC1F3FB44590" modified="2018-09-12" version="1">MMLAKLIRIVDTLNDQGTGASVLLLQVHDHLGVGDRSIETVHGPPLSQADVGGPHMPMLEDARIALALEVRLDSNRPQLVIILAELGYLDLPRLLSNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N1F6</accession>
    <name>A0A2X0N1F6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C007g04531 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C007g04531</name>
        <name evidence="5" type="ORF">BQ5605_C007G04531</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin interacting component (NIC) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY61145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N1F6"/>
    <dbReference type="STRING" id="796604.A0A2X0N1F6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007231">
        <property type="entry name" value="Nucleoporin_int_Nup93/Nic96"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11225:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11225">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP93 NUCLEOPORIN NUP93 DEAD EYE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04097">
        <property type="entry name" value="Nic96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="211"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY61145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1005" mass="112714" checksum="71D0CC2116F17F60" modified="2018-09-12" version="1">MTTLQSLLEQSQRLESNQLSSTLSLPSATTPARFGFAVPSSSFDAHHPSSGTLTNDRRLPTIQLGLDQIEAQSRRIAAKSLQHRHGHANANANAAFLLAHGGVNADQLQSTVDHVNLTGTFEPLLPLNDTDVQVGVMSQPRSTHHTHTRLTPATPLFALYPQGFLTHTHEQAIIASIEQGRRQTTADFYRSLDASIRHDWKRQKENLFDELGRHQPGYPSGSSSTAPATNSTPKRGLAPFAQDRASPLAPLPSSSAAGGNNNPSGSLQMHSRMMRYDRVVRRLNEFRKQGFAFALVSAFGEASIGVTANTTHRAGDLKATQTTETWRLLAHLMQERDVLNGEFQRKALQERQYAAAYLGLAQDAVQAAQLRKMIAEGAKHHLEEQFMNYVEKLLASRPTEAGLGGVPSLQNKIRAFLNVKFHKNGQWTNPNLEVRKTRPIANNTPVWARIYYLLRAGHPSEALAFATENEAQIQKLEKSFVAYLKAYLDSPDQRLPKLLRDRFLSEYNQRIRYLTDTSDPYKHALYKLIGRVEINRRNVPGVTQTTEDWLWFQLSLVREAEADGVVGTEAPHESYGLRDLAKVLVKFGEAHFDPKGNRPMLYFQVLLLSGQFERAIAFLHQHSQFHVDAVHFAIALEYYGLLRIPSAPHTSDVDLLVVEQDSSGYDLASIHFARLLHRYTRSFAQTDTEEALNYLYLICLNADLPSPLGPNQIKSCHDHIRQLVMETRNYAQLLGDVKNDGTKIPGLIERDLKLIHLKDERSYLFEIVKSAATRADQEKRFSEAILLYNLADEWDSVIAVLNAELGQSLTKPSIHVEGANRGANRGANEDYFSKSNATVGMAAGQEDIAQIAHSILQHYDRQAGGAGGRISRKNRETCHVLLRLKEAMTLNEQGHFEKALQTIQDVNLVPLHGDLVAIIRAAEEFKSLDETLVRNFDTILLTTMQLIYKIHQAFKSSPFGDAARQQSMVELRQKARSLMMFAGMLRYRLTSETYSQLTRLDVFIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N4C1</accession>
    <name>A0A2X0N4C1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AP-1 complex subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C005g03306</name>
        <name evidence="12" type="ORF">BQ5605_C005G03306</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY73574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N4C1"/>
    <dbReference type="STRING" id="796604.A0A2X0N4C1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016482">
        <property type="term" value="P:cytosolic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017107">
        <property type="entry name" value="AP1_complex_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037094">
        <property type="entry name" value="AP1_complex_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GAE" evidence="11">
        <location>
            <begin position="766"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="515"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR037094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY73574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="882" mass="95944" checksum="8F4D05A19469B279" modified="2018-09-12" version="1">MVFYNLKALIKAIRSTKTIADERALIVKESAVIRTSFKEEDSFTRHHNVAKLLYIHMLGYPAHFGQIECLKLVASPRYVLLTSDVTRRALCREAESLSTFIRCSFSDKRLGYLGIMLLLDENQEVLTLVTNSLKNDMNHSNASTVSIALCTFANIASEEMSRDLVTEIERCLGSGNAYIRKKAALAALRCIYKVPDLVDHFEGRSTSLLSDRNHGVLLTGVTLVTEMCRLVGGDPFRQAVPLLVRHLKSLVTTGYSPEHDVSGITDPFLQVKILRLLRMLGKDDVEASEAMNDILAQVATNTESAKNVGNSILYETVLTILEIEAESGLRVMAINILGKFLSNRDNNIRYVALNTLNKVVAMDTNAVQRHRSIILDCLRDGDISIRRRALELSYALINEQNVRVLIRELLAFLEVADNEFKLGMTTQVCAAAEKFAPNRRWHIDTVLRVLKLAGNFVREEVLSGFIRLITHTPDLQSYTVYKLYTSLRADVSQESLTLAGVWTIGEFGDILLQGGTTPASGDDEESAGSTTSEAVSEEDVLDLMENVLISPYTNNTIRAFVLTALTKLSTRFEGAAQLARISKALHSFDSSVELELQQRAIEFGALLSMDSIKTGVLERMPPPELRPTVMGTVSEKRPVGSLRRDKDVRGLANQTQCALLDIDLMGEDSGVSAAKVSAPAARARTAQDLLADIFGSSNDEPASATAVPASSVNDVMSLFGSTSISSQPATSSSSKSAFGNDLLGLSGGAPAAAAVIRPSPVAAAPAPLGALEAYASNGLQITLTPMRDNSNKLVVNILAKFTATQPISNVNFQAAVPKTQKLQMLAMSKTDVEPGATETQQLRVMVAAPGALVRLRLRVGYVVDGEQKQEQTDFSFPAGLMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N781</accession>
    <name>A0A2X0N781_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C023g09605 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C023g09605</name>
        <name evidence="5" type="ORF">BQ5605_C023G09605</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ23594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N781"/>
    <dbReference type="STRING" id="796604.A0A2X0N781"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22696">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22696:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="738"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="442"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="550"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="628"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="40"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="449"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="462"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="551"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="566"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="637"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGZ23594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="793" mass="87283" checksum="8F94A5E235F102B8" modified="2018-09-12" version="1">MVRNVLFAVAGYTYERTLRPMRSWLHRQLVDAAASSSSPAFESFASSSDPRSPSRSRSSMRASTASSSSSSSPAFPGPMSFVTSSFFVALLGLSILLNRIHHLVPPRRPFADREPLPDGSNAPLPTKLRLALRLPSLVLLLRSSTLLSALLLAHNYDSHLFSSTRSGRAFVRALSFLTPWAGRSELSRLVQAADGSRLPYAIASASTVMWEVFVAVALVVVTETFVRALADDLGSQASFNLLSFSFLLHLHSAPIYASPPAGQAWHPPTHLYVHLLLTLLELFVLHTSFIWTPPRRSLRLAITAFFSLIGQAILSIGFYRAVYAPQGRRGPALLDDSISWEGTVWMSLIPDLTFEALALMTIVLRALAILLRREEMTMEGVFGHRAHWPKRSDDWGVGMIKYATSCLESSTLAGLANEVSPIRIMAPLPLSFLSLQLPDTTTPPTSDIVRLGRSGSSSSGLVHRRRPSKKSPRHSPQEGFANEIKSIEVLRRQGEEVGGIGGGEQRRNAWRSLWGLAWRMCFFVVWKTYRAFRRGYLGVVDFVGYGDDEDRESHAMERWVPRGSGEEIEDAEDGDYVPSEDDEDEDDSSDDEELVMGSATQVEEEAPSSGEDDDGEAASLLQELVGFSSSRHRESDGSSSTSPDASSALIRNHDHRQTTNLANVDEHADLAPLLLAHYFAPSGTSPMTRRRYASLSSPNPSAPEAFSSAIEQRRLELGATSTASSSSTSGDPPYRRLCVICATEERSIVCWPCRCLTMCDGCRHHLSTRTSAREHLCPTCRGKVEGYSRIWIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N7B8</accession>
    <name>A0A2X0N7B8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C009g05588 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C009g05588</name>
        <name evidence="1" type="ORF">BQ5605_C009G05588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY82707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N7B8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY82707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="86" mass="9749" checksum="0893CC673B538B8E" modified="2018-09-12" version="1">MGSYNRRARKSLPDRIRTAKKHIPDACRNRVDDVLHPHDPKTPLEPRCEDDVLAIARPPLAAADKAGENAIKLLDDLWGFFFDWGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NAP3</accession>
    <name>A0A2X0NAP3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C031g10999 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C031g10999</name>
        <name evidence="3" type="ORF">BQ5605_C031G10999</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000068">
        <property type="protein sequence ID" value="SGZ07194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NAP3"/>
    <dbReference type="STRING" id="796604.A0A2X0NAP3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PROTEIN YIPPEE-LIKE CG15309-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Yippee" evidence="2">
        <location>
            <begin position="38"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ07194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="131" mass="14888" checksum="5C40874A6E02FB55" modified="2018-09-12" version="1">MPIPSDRSNSYYTEPNTDPNCPPKRGLQHREYLTSDVKVFGCRTCKTHLSIHEHIESKNFNGQHGRAYLFTTVYNINAGPPEDRPMTTGLHTVRDISCAKCTANTYKAYDASQKYKEGKFILERTLTVDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NBN4</accession>
    <name>A0A2X0NBN4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C044g12176 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C044g12176</name>
        <name evidence="2" type="ORF">BQ5605_C044G12176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000114">
        <property type="protein sequence ID" value="SGZ31443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0NBN4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ31443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1438" mass="161341" checksum="CDD1F5230ED11B1C" modified="2018-09-12" version="1">MYLDDPDIELLDDDFERMAPLLDVRVSELLTFRFDNPDTQIQLSWSTDEPLEFDTLPRPLRAWRDKFKDREAITAARKQGYRSIAIAGHRLPFGVERIWRHIDYAERMRSVVINSQEWMKSYLGVDIENQPLIVKALEVLPSLLVEDQYTPSMILGCSASLRTLLDFFGTTWLGETAMDVAITSVLASSRVQASTAPDKVYGAFPSDLMAILVASRTHQPDSPQREVLDKYIFASSLVPYRTLADLRSFVRARPQSVWFLPLCFRDHWAMARVDSARNSALALFDYLELHILNTEPKQGRMAQQADGSSCGPAAINVVETELLSFHRLATFATKSQHLTHDLPAPIAGIDRNELDVEDLAEIENDEQTWSGICFRSDSETDDDCTTDDDCTTDDDCTTDDETPKSGESITARRARLAKEHLKDVEYSKARPAAFAEFRAKVKQLCPGSDVKIENPRTVQCGRCRTYHKMKTRHGITRFMKHLNKKPPCTNMRKIDHYFAVRSPAETAVQSQGKSLADPPACPGLTGKRVEVYLSKSSARGGGAPSRLKLIKRRFPRIGKRVLTRFERREINNLEANEWTWVKDHSAPRVNSVNCTRIGMESQCGTKLESCAKCKALLRTKAFSQALHRPRAVGPTIKFTNKRLASVEAFMSKVFKEHQGLEELLGTKDGKVYLRFAQGLVSGELAGANILKVMAKVAVIKHRRDAQGKDMRGYVRDEALLDFEHALALASPTALRVVQKTVGGVSMRTLQQVSDLSYPSFLQATDDSKPLRQHRATFEKPRFGLDEPHMQCIIQKILSDGKTFNLHVDDTKLRQVIRTTRVYSKDKEAEARLRGQKIFRHELVDMVGPPIVYETTQELEGIFRGPNPPIAGTKVGDYVRVYMLAPNDVSCRAQYFAAFVIGDSPSSSEAADELESVIQFLVNAGVGHLLASISADGAASEGVLQRVMAKRLGGDEGYTGEGNRRRELAHVIPSPGPDKVFPAIRLASVQVGNTPTCFNRDAKHLSKNLRSACDSGARAIYGGTGCIGYRDLLTLLNVEESARTLYLRDVIGRDRQDDNATHRAFSEATLALACRLYEDGKSDADAIVFLFLCGELHDAIQNRSLQPIERIKMLLTVRYTFEGWLPFVRNRPGYNAQSFIAKETLDGMRKVVDANIALIRNYRDFWPEEAFIPWRHGTEMVEHFFGGLRKVVQEFDASEILQSASKVTALLGLMRKLKTETAGSRQGYHHMYDRLDDLDLVAMRTYPSDEEIRSTSLVAAGLAKELLLGLRMWDIIQYQKSNQLEEDIPVNASEPWHFEPEDAEPLSYLADLDRTLDGIRTKTCQGLVVLDPKERKSVKNAVRSLAALGLDNDAALLAVQQAYDEADAQAEERFLLDAIVTANESLPGRAQIILLPSLLRHDSRQLALDLKSLIQHRRAHQCAHLRVVVVGASLVTWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NCG0</accession>
    <name>A0A2X0NCG0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein mS29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C020g09133</name>
        <name evidence="8" type="ORF">BQ5605_C020G09133</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS29 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000082">
        <property type="protein sequence ID" value="SGZ17619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NCG0"/>
    <dbReference type="STRING" id="796604.A0A2X0NCG0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019368">
        <property type="entry name" value="Ribosomal_mS29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10236">
        <property type="entry name" value="DAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGZ17619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="411" mass="44594" checksum="89CDBB209C988EF6" modified="2018-09-12" version="1">MSCVTANKALWRNKGKAGATDEDASSSSGGSRGLGNVLESVTLKPKILSSLAELQPNTLTQDSVGQVKAFSSQALQAFKNWTIPSLIQKEFSATTRPATVVRSVTLKVKNLIDQSKGNSSAASRTVLNGPSGSGKSVVMLQGLAYAQATGWIVLYLPSATPLVNSSTPHIYSPQRALFDQPQFAAQFLQRIAQTNKTLLTSLKTTQPYELTADLPIGTSLYALIIQSSPQDRSAPLLLEALFFELSRQTSHPVLLAIDQAQGLFNTTQYVDPTYRKLEAHDLSLPRLLLDYVGGVKNFSNGLVLISPSHQSTTTSPALEEHLSSSPYPSYTPLGPSHQIYSSLLSSVRQLSVPARLEKKEALGIVDLLMGFRAIREVGQEGVDDGTFMKALMESDARVREFRKGWERNQAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NKM5</accession>
    <name>A0A2X0NKM5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C058g12704 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">BQ5605_C098g13108 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C098g13108</name>
        <name evidence="3" type="synonym">BQ5605_C058g12704</name>
        <name evidence="3" type="ORF">BQ5605_C058G12704</name>
        <name evidence="2" type="ORF">BQ5605_C098G13108</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000002">
        <property type="protein sequence ID" value="SGY11508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000091">
        <property type="protein sequence ID" value="SGZ29118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NKM5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY11508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ29118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="390" mass="44735" checksum="CF0BD8EDAEBA372E" modified="2018-09-12" version="1">MMNVFYKKKKTWGFFSSTARVEKLYRDSARWGAVVAAARVTLPTIKSELLTLPELLSLPPRLPSLYAEGAKHAYDDADAVAKFAQIADLYWRDEGKGWALVGHRRGFWQHSKEPALRHEHVWARVGQKLKAKALLPKTAVRPARIPLKEDPHPRCFNFFGLTRPFTIRKLRRLVNTVRFPGKDGQDRALPGGQPQEPRVKRFPEGTSQSGRQRFWSWLHDRFASAAEQDTHWRLMYDVTPTRKKQHVQGHASSPSCLFCGNDAAVIETVSHYFFGCAYSASYWSGVLRILFDKLGIEDTDVDPSTFTQEQLTMGLPLLRGRGRTTSKWMWVRLACAIGFQRLHLLRWHVHQRFEKDRVVAPPSIPSALRAFNRDYLSRAGFVPGARDWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NLG3</accession>
    <name>A0A2X0NLG3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C011g06474 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C011g06474</name>
        <name evidence="2" type="ORF">BQ5605_C011G06474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NLG3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="410"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY12345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="638" mass="67772" checksum="308E86B255AC8BFB" modified="2018-09-12" version="1">MDNNNNTNNASHAAIPPLRPDPPDPPGQAPATTTKSYSAAVGARSAAKHGNATANASTAVAAHPLMHNIENCVIINTPPSTSVEQVLLALDKYYPGLTGAMPCVIKGQRGLRFPKAADLDTLVANGLTVGKNLCKVEKLYSSTRGGVVQCTLTGFFSDPEGLCLFDEQIAAYGTVLRCRIQYIGKTKHISGVYDFILALKDVDVLPPASLSIARDGVTERIPLRITGGMRHCVFCRSAAHVRKDCPVAPACKSCASTSHATQHCPARHGSSPQGPPTSRAPQASTVTTAAPAAVSKSISPTSAHDRTTKKRRVEQDLAAQTEDLSNRAQPDSLSKNARPEFSFNFPCKTATPPAPQPASNQGIAYSLVEKSSKSPSSETTSPSPSPPPATPKSIITRSKLIAALSKPATREAPPTAPALEASEPSPEPSSPTPLPSAAPKARPDDADTDDEADEEAEDQEAPPKDSINEDRKRASLFSNLRSHNADVFLLSKTGQPSPERVAQWTQECQDLKLSALFTPFNNTAILWKSDSVVITFDPESPPNTLRASFSFPDRVTDATFCVGDSKVRVVSIYAPSSNKPDKKCFLSHLSTAIRLKGTRSLSSLTGDLADRCKLYGLQLASGVSPMGRVLRYGTPVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NS44</accession>
    <name>A0A2X0NS44_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C011g06518</name>
        <name evidence="6" type="ORF">BQ5605_C011G06518</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="4">
        <location>
            <begin position="528"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="Helitron helicase-like" evidence="4">
        <location>
            <begin position="886"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="1274"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="5">
        <location>
            <begin position="1588"/>
            <end position="1632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY12473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1740" mass="195734" checksum="B0B386A41E612E61" modified="2018-09-12" version="1">MSANFHVPSLQQQPSRRALGQQRRRQHAATNPSTRRRTKWIVESICTGSRQSQCRPASATGPQSFTITKDKDRRNEPDEGARDEGRGTRDKSREVLGTSQERRGRETRTRDECKDVTFDEIPVAEGKERTVPSLSRVASSSTEATATSATTVVDQRSAGQRQRQQRARERLSQTVPTALLPLPEGPFPQHNLGSMTLQCPICLALHWEFEKLSTPGGGTLFKLCCADSKVRLPGIKRPPPELLELLTGDGPVEKIFRDRILAFNESFAMASFGTSKGHGIISGSGPPSFYLSGTVFHRIGTLAPGPADDPVFAQILFLAPTERVEARRRFNGPPEEVRRLDSAYQQIVAVLDNMLRLHNSRVKLFLTAQEFMNSKASHMYQLRLLAPRNQDPRTYNLPTQEEVAVILPGDDTKYRSSRREIIVRLRHPPNNDGRGIQIIHDGHPALMALTYPLLLPYGKDWYHDRIPLSQNAIATEAAWRVRDENGVLQRTTDNANANPQTRTAGSKHVTQSQFNAYCFHICPHNISYPTLFLGGRLFQKFVADTWALTEQERLYWMRINQKKLRAKEYLSLQASLAEGLDPAQIGKRVILPLSHAGLPRQMVQLYQATMAIVRVFGAPDMFITMTCNPAWSEIVNALLPGQTASDRPNIVARVFHGKLKALFGGVLGVGRAPGVFGKVIAYVYVVEFQKRGLPHAHILLIMDPEDKPKTNDNYDKIVTAEMPDRNRFPALFETITNSMLHQQCDCPGKHTCHDDHGKCTKRFPKRLQPRTTSEDGGYPHYRHCGIHQYVKFPGTAQEEVYTDANVVPTNPFLASKYNCHVNVEIASGVAAIKYLYKYVYKGHDRTSFTIDKPRAQDEINNFLDARYVCAPKAIHRIFRFGMHDGKPQLFAQVIAYVYVVEFQKRGLPHAHILLIMDPEDKPKTNDDYNKIVTAEIPDRDKFPALFETITNSMLHRQCNRPGNHTCHNKHGKCTKRFPKRLQPRTTSEDGGYPHYRRRGIHQYVKFPGTAQEEVYTDANVVPTNPFLASKYNCHVNVEIASGVAAIKYLYKYVYKGHDRTSFTIDEPGAQDEINNFLDAQYQQVRFDPDHGAPDLSVPPETTLTAFIKLCAKTPPNHNAQELLYVDRYYLQLLLLKVPSPTSFADLKTFNGVEFRTFREACVERGLLRNDAEADRCLTEAAVFRTGHELRHLFAMLLTVDDGVTNAAQLWTKHYDNLTQDVEYQLRNQRRQPIITPEHFNDKASTNCLIMEESATAAELDELEGLWRNNFELCNAEQRVVVETVLDSILNSRGKVFFIDAPGGTGKTFLEKTILARIRSEGKHALAVASSGIAALLLPKGRTAHSRFKIPIDIFNDSTCNVPKQGQLAELFRMCDLIVWDEAPMQHRQCFQLVDRMLQDVQLSTARFGGLAVVLAGDPKQCLPVIPKSLPPQIVDACIMNADFWGEVEVLHLSVSSSSSLTFRPYTNRGTVQAQTNMRLLAAADRMTETEREKAHDFANWLLGLLLPATTRNRSGLIRHVYPVPAFELNNMSIGAKIKYFQNRAILAPKNSLVDQINDMVLDLLPGDPQTFYSADSVENEDESLFLIEYLQGLNIPGMALHAAKFKVGCPVMLLRNLDPAAGLCNGTRLLLTWLHTRVLEAIILTGDHAGQPVLLPRITLKTGSSAELPFTLHRTQFPIWLAMAMTINKSQGQSLAQVGVCLETPVFSHGQLVLLHQTENEKADNVTENIVFRMVFELTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NSA8</accession>
    <name>A0A2X0NSA8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="19">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">BQ5605_C017g08408</name>
        <name evidence="24" type="ORF">BQ5605_C017G08408</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 19">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="19"/>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY19963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0NSA8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07541">
        <property type="entry name" value="P-type_ATPase_APLT_Neo1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000085">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000009">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF5">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NTM8</accession>
    <name>A0A2X0NTM8_9BASI</name>
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        <submittedName>
            <fullName evidence="8">BQ5605_C010g06185 protein</fullName>
        </submittedName>
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        <name evidence="8" type="primary">BQ5605_C010g06185</name>
        <name evidence="8" type="ORF">BQ5605_C010G06185</name>
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    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="SGY14445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="796604.A0A2X0NTM8"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
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    </dbReference>
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        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
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        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
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        <property type="entry name" value="Sirtuin"/>
    </dbReference>
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        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
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    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="7">
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            <end position="399"/>
        </location>
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    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="420" mass="46367" checksum="F15C6221B480AB36" modified="2018-09-12" version="1">MRRSLTSHLPIRIPSLTGTPHPPAPHMELTDSTRLLIDFLKRGKGKTVVLTGAGVSTDSGIRALRLGGEGLSRIEWKLYHELATSFRGKGVAELSFIANVNFTEEQKNHRPIFYHEFIEEESKRRRYWARSYLGYPPVRVAEPNPTHYALAALQKLGHVSHLITQNVDGLHHKAYDNDPTTYLAPPPIAPPTTASATSPSGSTTEPKPLPFEPEILELHGTLRHAHCLSCQTPIGRDAFQDRLSALNPAWAEYSHDLESGKTKPILNPDGDVELGKGVRYEDFNVPACDHCGEYMMKPKVTFFGESLLPHVRDLATSWIESSTQLLVIGSSLATYSAFRLIRLSKDLDHRVGLINVGESRGDGLVDFRVGWGGGAVEVLPPVVKGLLEDGPEVEEVLKTEVEEMMRRGRIKRIGNGGTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-02-22" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NV94</accession>
    <name>A0A2X0NV94_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C013g07158 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C013g07158</name>
        <name evidence="1" type="ORF">BQ5605_C013G07158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY14899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NV94"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY14899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="672" mass="74679" checksum="503C54A0773EA138" modified="2018-09-12" version="1">MVEELMLPELTKQVDHDFLMSEIIPRISVCSISDLVHSVSRIKPAQFNESARKAFARPGRLAVRDTFQEDCARPTDQRQAQWLLPLATSVSAMPSALLLGGHIRRQNLTLAHAQRPARLTGAGAHYSPGLIERHHFLTCCDKLASAKGGPGACRMLVPLAFDVHGPEHDTRHTPYPLVDVLLDLAQHVLTQPTRLFAPGLAILDDAAYFTVLDHEGCRIATISDCWCEGYGELASVLSILLGLDVYSAGLSPLFRYACHSETGIAPDAFCTRYLRLSEPEADAPLVGRTVEFVHEEPIKLVQSAVVNGSSLFSHCTVVFQLTRESLVTKSPSSSEDDPKPSFVLKIQHVSPKFVGHEAEVLNAIVKRCASAGSSTSSRLLESHVALPEKAKSLSRHRSQMKESDLPVLINREDPKQREQYSSRRTLDVIILRNPTRFPIPVDDGRGPEHPLSQALKVFDQLLTLLPVLFDLGIHHRDLSLGNILHYQGHLVLVDWGTGIVAPRGERVPVAAEDTGSFRITRATAPFQAQSHTWTWLNAVNAVNKIPFHGLRHDFESSVHWFLLALQLRALSQPATYPLCLTRLELWGGGGEYPQLREDFLEDLKKVDTDLHGLVELMTRNRPGRLPPVGTSAARHHLAVERKIVEVQAELRRMLEKAQQPDYEGLLVRFVKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NW30</accession>
    <name>A0A2X0NW30_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="5 14">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">BQ5605_C015g07785</name>
        <name evidence="18" type="ORF">BQ5605_C015G07785</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:18977"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Polyol metabolism; glycerol degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="5 14"/>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NW30"/>
    <dbReference type="STRING" id="796604.A0A2X0NW30"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.870:FF:000001">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.9.10:FF:000001">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="entry name" value="Alpha-glycerophosphate oxidase, cap domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985:SF15">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00977">
        <property type="entry name" value="FAD_G3PDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00978">
        <property type="entry name" value="FAD_G3PDH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="6 14" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="752"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="789"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="841"/>
            <end position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="SGY17448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="864" mass="94832" checksum="8D035AAB2B0BE82A" modified="2018-09-12" version="1">MASRLFSRGRATASATRRRTWLYAAGLTTTTGLGYTLYSSQYGSHASEDALLPSDPQSLYRQGRALRMDSSSSSELNSVEVAVGRPSSTWTPPTRAEMLKALGAGSKAALASSTSDLFGLRNVWDKALSSASSALSSSPHDSEPTFEATSAPGQTDHEDGEFDLLVVGGGATGAGVALDAASRGLRVALVERDDFSSGTSPQLRSLFLSLHLSLYSTFIGTSSKSTKLVHGGVRYLQKAVFELDYEQYKLVREALHERKTFLYTAPYLSHPLPIMLPIYKYWQVPYYFAGTKMYDILAGSANMESSYLLGKGKALEAFPMLKADGLVGAVVYYDGQHNDSRMNMALIMTAVQYGAVAANHVEVTELIKDQNGQIKGAKMRDVLTGKKWETKAKGVINATGPFTDGLRQMDEPSVQPIVSPASGVHITLPNYYAPAKIGLLDPATSDGRVIFFLPWQGNTIAGTTDSPAAVEQHPVPKEEEIEWILNEVRNYLSPDIRVRRGDVLSAWSGLRPLVSDPDAKDTQSLVRNHMINVSSSGLLTIAGGKWTTYRAMAEETVDRAIQEYGLQPMRGCVTTKLRLLGSHGWSKMMFIKLIQQFGLESDVAKHLTDTYGDRAWAVCSMAEPTGLRWPVHGKRLDPVYPYIEAEVTWACRREYAATAVDVIARRTRLSFLNAEAALEALPTVIDIMAKELGWSKAQQNQQFKDAATFLHSMGLKQERLNKLTLNDVRQGKHKERVEIEDEVLARTVFSAQELSQLKSKFNEMDFDKDGKINYKDLSRTMRRLGFANVSKETVSNIIREVDGNRDGKITLEEFLDMAAGVKELSLTNAFTDIVAKVAENPNDDGSKNGLTYEGKNSARSGGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NWN0</accession>
    <name>A0A2X0NWN0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01584 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01584</name>
        <name evidence="2" type="ORF">BQ5605_C002G01584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY34047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NWN0"/>
    <dbReference type="STRING" id="796604.A0A2X0NWN0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="16"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY34047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="360" mass="38733" checksum="9AE87F883979D14B" modified="2018-09-12" version="1">MSIPTQSQALIVVDQGKVAVQTVDTPQAGQGEIVVKVEAVALNPTVPATLICYHRQHWKHRDFVSPPGAGLGCDFSGRVVQLGQGVQNVKEGDRVAGFIHGGKDEKHGSFAEYLKTEATLVWKVPDSVDAEEAAALGGIAPHTAFQALNLRLGIPQPSKPISTSQPLLVWGGSTSVGLYAVQLAALAGYRVVATSSPKNYDLVKKYGASAVFDYADDATPSKIRHEFPELALALDTISEKGTTLKTAQSFKDKGHVVVLLPPSDEGLDNYPNVKIEHTLVYTVLGKEFNFAGKAFFPAMPKDKKAIEEWSEYVPALIESGKLKTNPLWRQEGGLAKVNEGMNLLKEGKNSAQKVTFKFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NXY4</accession>
    <name>A0A2X0NXY4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C017g08322 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C017g08322</name>
        <name evidence="2" type="ORF">BQ5605_C017G08322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY19804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NXY4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635:SF196">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="153"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY19804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="838" mass="94378" checksum="3566829A2EE55665" modified="2018-09-12" version="1">MRLRLGFRGSSYGAALRSRIDPSLAGPSSIFIRLRKVRASDLIPSLSVDNVVHSDPDSMLGAASKYFEGVYEDRAIDDDALEKIIDGLASTRLSHADSNKLEGAYPLEEMTKAQETCKSNSSPGPDGLPIEFYRATWTATGPILRDVINSIPTDERPISLIDADERIISQAHNQRLAPLLETLIGSTQRGFVPNRWIGTNIAEVQCLMDPGLPGSEPVSGLLAVMDFEKAYDRLSHTYIDAVLSAVGLVPKTRQWYRATYTNQSASIYLNGWLSAAFDILSRWPWPENPPVVPSDLYKPIRLDIPQRMALGRVRYPPGVRQGDPLAPSLFVLAIKAFAVQIRSQVKGIASPGLPTIRELLFADDGCCALHDTSDLDHLNRAIELYERASASKLSDAKSFLYPLGSFRDRPIPSHLGSWRLSDSQFCYLGVQVGMDIAEDAGWEEVKSATVARIRSIPMYDLPYAAKCSIINIYYYTKILYYNRFIPSPKSVVKEIEDAVMIAIHGRASDGSQKPPKVSRLRLCTPLDHGGFGLIDSPRRLAIDHAKWVFHLRDPDGCFIRHLFDIRTRLQAANERTPFTLPKSGPNPHRRSWVWIWWAYFCHPPPQWERAVRKTKALLPPRWIRYFEAWDLVTTLNPPPPPPPELSKSPNLERWATHVLYFPAGHGIQLSVNPTLFRGPDGEVMTPYSFVNASKRHPDFLYPPILPVGHQRVFCLPEQRWNAWRKALRKVRRVHSDAEDTAHLLSLGSLHPAVGCPFARRLSSALTPLPHPDFVQFVCPVVSRSERRLVELCLLFFHSIWKLSRHRRFSSDPLEPIAETAFEELRASIQESKGRLVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P157</accession>
    <name>A0A2X0P157_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C006g03739 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">BQ5605_C006g03747 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">BQ5605_C017g08297 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C006g03747</name>
        <name evidence="4" type="synonym">BQ5605_C006g03739</name>
        <name evidence="3" type="synonym">BQ5605_C017g08297</name>
        <name evidence="4" type="ORF">BQ5605_C006G03739</name>
        <name evidence="5" type="ORF">BQ5605_C006G03747</name>
        <name evidence="3" type="ORF">BQ5605_C017G08297</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY19758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY53239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY53331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P157"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046921">
        <property type="term" value="F:alpha-(1-&gt;6)-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13132">
        <property type="entry name" value="ALPHA- 1,6 -FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13132:SF29">
        <property type="entry name" value="ALPHA-(1,6)-FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY19758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY53239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY53331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="610" mass="67098" checksum="FAA1E6B578F685D2" modified="2018-09-12" version="1">MKPRLPALVTPPSSPGGAGAVGSTGSPRRAMAKVRHASIAIARSHSKFAYFRILICIVLTAAFVVFGPSEKILLGVRHRIEAELASRNVRDERPWVPGETGTAQPPGHEHRHDDEHKHRHHSSLAPANQSAHMTDGGDEPLAQSSSPPSRLDKIYNAVERPVSTNEKPAICKRTLLFNMAGAFRFALKNSSFGVMIFSAWLAKLIRPQLVVLHSGLHGFGSEVLMLTRMAVLAEMFNYSLLVDSSRWNYGSWEAVFQAPALDCKPPPSTTWRARIKFDRKARTLDKAAVRKSWATFDHVTWRSRDNDGLDKALLDTLTSSSEMDVLHHQDLKELVHPAADRASLTTPELKLASQLVPSALQVIFTRQAQSLSALWRLSRPAAVRVRAARANLKSLTRQLRAAQQLSGDASPIIIGMHVRLGDKYKEINRIGPQAMMDSGGRSTLPQATPTKTSHLDDRAIEKYLVAAINLVERVRRNGVVLSLDERPVLLVASDSLTVSTAFAKHKLGRAFNVIDIADLDPSEAIAPDESIHGKQRMRVAENGFDELEFNMLPFEARERVAQGFVRDITILAQVTHGLVMSASSNVGRMLALLGGEEKIEQGLIASVDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P1E0</accession>
    <name>A0A2X0P1E0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g03887 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g03887</name>
        <name evidence="2" type="ORF">BQ5605_C006G03887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY54550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P1E0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="601"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="666"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="714"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY54550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="765" mass="84796" checksum="027CF4B17D8C415E" modified="2018-09-12" version="1">MAPRRDSFTPGQGFLDNTTNTYRPSAFSSSSSSSSASRNKSLTQARLFGMHKAAIITPRATSTAASGSSSRSRTASTKSMGLVDAFSRQASQSTSSASKTRASQSRRRVERAQPDARSPASGDDEDDDDEDERDEARRPDSSHQWRNRGRDVPSSSRHSEITCSGVGQENRAQSRRHSSESESHLPSPTSNTFARSILNPSSKRRGPRLSFDDDPHENDDDDKMMMMGEEARREKNRIWTGGRAQLDLVPLRDWEEDQAREEKERDKGRSSATAVVEAESKGKKPLEMLGDEENVEIRHRVQQSTQSRLDHPMSASPSDPETETDEPFPLSARSKPRMIEAQPSFADSSESDVAEYLQQCLVGGRGDELVPSSSPDAEVLVCDSDEETLDRLAYQFGRGGVDDSGFADYNDEEEEDGGSEERGDAGMILPSFQPRSDEVTILEPETRKAVGLERSESSILMPPPPVPIRQQARQVVKVEEVPQPQARDQVSFDEIETQWAVHSPIKSRPNTTLETIPSRPSTWSSLDAAWQGARPLTPPPPEPRQANLLEFFPKTHEARADEGEEDQENWIIEDSQPGSSIPLGQHEMRAFQAALITTRGMGKKKIRSGNGLGGIEEEDVEEAEEEVDVPSSDQEDGPWSPLGSPVRMRFPGSGIGKETEMVQLDAVEEEDGEDVRGDDDAEVVPEAEELGDDSMDFLPPLPSFPPSSQMSSTQRDRIKSRKDSGEMEEAEREETQWESYWTVEAVEPSPFHALMDDDDEEDENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P1M8</accession>
    <name>A0A2X0P1M8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g04017 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g04017</name>
        <name evidence="1" type="ORF">BQ5605_C006G04017</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY55404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P1M8"/>
    <dbReference type="STRING" id="796604.A0A2X0P1M8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY55404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="66" mass="7553" checksum="81243F2B47AB2DA6" modified="2018-09-12" version="1">MVRSFALVKIYGMAREGRSLVSGQYPRVKARLVSLYWIAFLSAPTAQQPALEIKPREDIRRCRGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P3P1</accession>
    <name>A0A2X0P3P1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C007g04838 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C007g04838</name>
        <name evidence="2" type="ORF">BQ5605_C007G04838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY63834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P3P1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY63834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="176" mass="18748" checksum="54EE72B666C16A43" modified="2018-09-12" version="1">MCSATTASTRAPATRGNSGLAPIRDRSTPGDTLGGGCSSGASEVVNVPPGTGTSGPLDAIIPRPVARFAMEQRFPCPLLPQHPTLYELLNMSRRYTIRRIRRPDDLKGFWKGVNSNALTAREEGGGGGWFKVIRRCTPNVSIGSCNTMSPLQSYLRSAGGQSTTTSLTASTRRMYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P4E0</accession>
    <name>A0A2X0P4E0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C003g02341 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C003g02341</name>
        <name evidence="4" type="ORF">BQ5605_C003G02341</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY40249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P4E0"/>
    <dbReference type="STRING" id="796604.A0A2X0P4E0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045117">
        <property type="entry name" value="ATXN2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009604">
        <property type="entry name" value="LsmAD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025852">
        <property type="entry name" value="SM_dom_ATX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854">
        <property type="entry name" value="ATAXIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854:SF7">
        <property type="entry name" value="ATAXIN-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06741">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14438">
        <property type="entry name" value="SM-ATX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01272">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LsmAD" evidence="3">
        <location>
            <begin position="273"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="346"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="539"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="772"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="455"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="539"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="583"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY40249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="841" mass="85385" checksum="77FCB937EB18CC9B" modified="2018-09-12" version="1">MPAAGAASSGSGARTPAPAWSAWSSPAATAAAMNASHARAAASSAFKPASTGSAPAPSAGSGSVTPTTVGALTESSTEAPQPATAAVPSPAAAPPAPASPAATPVKAEPELHQRLVVLLLALVGSKVVVTTREGKRYIGILAASSPQHELSVNLRQAQQVDAQGDHIPGEAAKPNMLVASRDLVELYAHDVALDSRTSSFTANSSSNREGFKTDLQVTGTSLGAREKKLQAWAPSGPGEGGGGIEHSISGLSLEDDSASGKGWDQFATNERLYGTRTDYEEEIYTTKLDRTGADFRQREQRAAQLEREILKGGGGALANNTHMAEERGAAFDDSNMNEEDRYSGVIRGPEAYVPPGARKSTPVAKPAVAAPNGASSGSASTPSVSTPAPKPTPHSGAQSQTSFQDPAILSASGSSRLPLPNAPNSRIPSPAASTNATASDKSDAASKATLDGHILRFVSDEREKLNERKQALLKEARETAEKKEKDSKLRSLLEFSQTFKLKGGTPTDLASIIGDLKPAANGNSKTVATVSAAAAKPAAPPAAAAGTPATRESTAPPARNATMSPGKLLPDIPPFNPEKARAAAEAQALSGASKTTAPAKPATAPLRAASAAVPRPLGAPVASTSKLTAAAPAFVFKPNPNASAFTPGASLGAGANRPVAATPSNASVSAVAGPSPAPASISAAVASAAPNHASAQAALHPFFGNKPYKRGHGGLYVKEEFAPFKSGVPDPATVDPRWPFYGKSYRAVYPVSVPTPPPLPLGPHIGMPLVVQSGSVNPEDGGPESSPPVQTSNLGAGGPHGPMRMPNQPPMHLGAAGFGAYPLPHMQPGGFVRFPGPFGHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P4Q5</accession>
    <name>A0A2X0P4Q5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00035 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00035</name>
        <name evidence="2" type="ORF">BQ5605_C001G00035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY43572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P4Q5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="633"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="678"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="399"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="635"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="690"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="725"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY43572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="817" mass="86968" checksum="93C6B141158C4E15" modified="2018-09-12" version="1">MVNWIDRWYNLFHPTPKTNAPTRAGESDRGHRATTPPSSPPARTSSTPVTVARVGLAPAPSSSGPSLRLPVRRASSITLYIRPKRDARDSEDDSFVHTPTRTAARDSSGDCEATPTIRTLGGDDDDDPDWRQPRHSEGVTACGSGDKADENGQGDWNMLASEHNPFHGLQINLGTPNTRADVISSRGGLTISRLGRPSSSKKTDCSASSSPAVSRPSSLRAWSSIAESPSDEDQKPSPSSSVRTPIGAIEESSLATVEVSKSPSTSLEASNKSLRRWSLHFSASSWKTGRPLARPPPPPPPSPSIAGPTTSALRGQIMGSEFLFDAISKPTMSLRPRSLSSKSTLKMRTKRRKKVFGVGDDDSPDNASSSVQDDGKVQQTKELALKPRQLGASTETQRLPASCCSSPPSTLSTQASSPTLCDESLESRDYFDDFGASSTGSYGISVLMNQRTEGEPLRRHSDDYSRYYRAPVARYFAPIATEFPPCHASDGASSATLPRRSQTPPFSRTCVSRHQSLSSATQLRPLLSLPLSAESIDRSSPSWSRHRSVTVSFTDAPSLPSPTSISSAFTDSNQSFEPPKSPNSLYKMKRTQYRATRRRTQSTGSNGSRGPLPAGHPQLPLLCARIGSARRLVTSDSDGSISSSSLERSSFGLEDGEPTPIVESVYVAKAWSIDTEFAAGSGGENDGFETGSNGRKSGTTLQIINPDDASSDGSTPILSPPPSPLDLASEPTVPNPLSTSSSSNISSSSTTPKTTPTPTPNLMSSTPTRGISYFPTPSPPLSALSPRTSNEHLKASNSSSIPFPTSPLHHQAVGIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P9D4</accession>
    <name>A0A2X0P9D4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C007g04422 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C007g04422</name>
        <name evidence="3" type="ORF">BQ5605_C007G04422</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NKAP family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY60376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P9D4"/>
    <dbReference type="STRING" id="796604.A0A2X0P9D4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040466">
        <property type="entry name" value="NKAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009269">
        <property type="entry name" value="NKAP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13087">
        <property type="entry name" value="NF-KAPPA B ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13087:SF0">
        <property type="entry name" value="NFKB ACTIVATING PROTEIN LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06047">
        <property type="entry name" value="Nkap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NF-kappa-B-activating protein C-terminal" evidence="2">
        <location>
            <begin position="10"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY60376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="117" mass="13028" checksum="F0D57CEFAD89A4B2" modified="2018-09-12" version="1">MMPGQKGARNAYGGALRPGEGTAMAQFVQDGARIPRRGEIGLESEQIEKFEQAGYVMSGSRHRRMNAVRVRKENQVISAEEKRGILQLQAQEKAKRENQIVSSFRELVDTKLAGQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PA28</accession>
    <name>A0A2X0PA28_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C038g11727 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C038g11727</name>
        <name evidence="1" type="ORF">BQ5605_C038G11727</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000061">
        <property type="protein sequence ID" value="SGY92259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PA28"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY92259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="137" mass="14326" checksum="855D8246D3D972DA" modified="2018-09-12" version="1">MRAHNLSHPLLRVGKQWPYSGCCSDAFALSCSDPATATNCRLGYKLVNGACSTIPFCFVPNPGVSNDGESSGEGCCSDPMATTACSAPNNATDCAKGYLRQRGGSCWEIPRCLNPIILADGVGCCQDPHATACAYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PA63</accession>
    <name>A0A2X0PA63_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">BQ5605_C007g04732 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">BQ5605_C007g04732</name>
        <name evidence="18" type="ORF">BQ5605_C007G04732</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY62767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PA63"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="17">
        <location>
            <begin position="168"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="405"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="SGY62767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1051" mass="116005" checksum="21A9AC5ADA1F8BE8" modified="2018-09-12" version="1">MRHLLPPVSPPAFPDDSKLTEDNYVDWDLAMSTTYAREVCAYLRKGQHDPSWPPAFHTRWEDYAARALASSLTVTTKATIGPLIQTGGSAHDCWLALAARYAPSDAQAYSTLIKDYFIPAQTLKKLAASGQVEGLDWTYSDLECVDFTCNACLTSKAHRLPFPPSSFHASEPLALVHSDVLSFPEESFSHKRYLVTFVDDFSRKTWVYPIGHKSEVLQTFKDWLMEIENETGRKVRTLRSDNGGEYVSTAFNGFCVARGIRRELTIPYTPEQNGRAERLNRSIVEGTLALLIDSGLPRTCWDEAAMCYIHTKNLSPHAALKGGVPNCRWSGAPPTVGALRAFGCRAWATVPAHRRDKLDPKGIPLVFVCGLSRNVTFLETEFPFVAVPARVTPLSVPGFYSRPPPADAPATPLPPVLVEPTQPPSLDDDATSSIHLPQRPPEPAPPEPALAPPEPTPLAKVKPTWEYGDVAKVGPDPGKYGEIDARNIIAGPRTRRQLVPTLITREDLVGGPDGPTPAFQGMLRAFASTKAGFAEHDLSVVRDPADWGDVIRSGQQDTWGGPAHDEFDSLLNEYEVFEVIDSCELPAGEILLRSGWVFRTKRNQHGDIIDRKARLVAHGCAQRPGIDFEQNYAPVVKFTSIRALIALAAANGYHVHQADVNKAYLHGKLDKPLYMRVPQGIDMPGKILRLSKSIYGLRQAGTIWNAEIDSTLRSLGHVPTRSDICIYRREHDGHSHYIALYVDDLLLVGPSTAEIDRVLDALELAYGINRLGPAEYILGIQVKRGHNGSITLSQERYLRDILARFQFADAKPAGVPMQPGVVLDFENSSATPEDRTRYLQAIGSLMYAAVGTRPDLAFVVSYLARFSQQPGPEHWTAIKHVLRYIKGTLDLGLTYRKTNQPLHGYSDANWGACLTTSRSTMGYAFILSGAAIAWCSKREHRVAKSTTDVEYLSLSYASGDAIHLSELGAPVPGPVVLYGDNQGSLALAQHPTNHQGSRHVRISEHYVRERVAEKEIEVRYIATGDMFADIFTKALGPKPFIFHRTNLGLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PAB0</accession>
    <name>A0A2X0PAB0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C037g11634 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C037g11634</name>
        <name evidence="9" type="ORF">BQ5605_C037G11634</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000062">
        <property type="protein sequence ID" value="SGY94179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PAB0"/>
    <dbReference type="STRING" id="796604.A0A2X0PAB0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000053">
        <property type="entry name" value="BZIP transcription factor AtfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051027">
        <property type="entry name" value="bZIP_transcription_factors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="568"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="295"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="447"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="637"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="593"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="454"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="536"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="645"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY94179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="658" mass="68797" checksum="BDD40A9711BDB655" modified="2018-09-12" version="1">MTTRSSRRVPVAAPNPAPHHAHTHAHSGHGGQGGTPSTDAHAQHHSQAQQQQHHPQAHLHQQHHHSVGPPASYQYPPQLHGMDNGMPKREESEQLGHSRHMRASSDPISRGGAFDPDGGHQLDQEPNPFEQSFSGPEPPGPIISRSGYGSQTPSFAGHVSRRARSISPNSLANRQTPGGLNKIAHFPMIPTPGNDLSQFGWPQQSFTPGMMGGAPFDPSMMRTGLTPLGGETSSGGGVSFPPPSPATAALFAMMTNNTPGTAEAAAAAGLVGGGPRPHEGPNEANNFEASFARAASGKHEGGSVQAPDFSSHHRQSQMGPNGRVGHGAMHPSHLQNQVHPPQAAFYPQQTPYGQPQSNFNNSYSQRAHHPGPGPLHLGSAGFPPNNGVEALYNLGQTDSHNDDALVAAAALSGLATPGFHGHTTPLERIAQEKAAASKQAGGTTVGIVAPTSVGAPTSTTSVSNPTQTESPAPSANGGSQPGNGAAAPAKGKRGAAGGGAAANKRKKADAEETKPKVAPAKKSKRASAAKAVSLDGMDDDMDDDMDQLEGEGQSNPSPAPSNPNETEEEKRKNFLERNRQAALKCRQRKKTWLANLQYKVESLTTDNDTLQATVTNLKEEIQSLRAILQAHANCPVASGADRRGSSVQNLAPNGQQRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PAV9</accession>
    <name>A0A2X0PAV9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C004g02786 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C004g02786</name>
        <name evidence="9" type="ORF">BQ5605_C004G02786</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY67557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PAV9"/>
    <dbReference type="STRING" id="796604.A0A2X0PAV9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051239">
        <property type="term" value="P:regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04178">
        <property type="entry name" value="Nucleostemin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1580.10:FF:000002">
        <property type="entry name" value="Guanine nucleotide-binding protein-like 3 (nucleolar)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000571">
        <property type="entry name" value="Guanine nucleotide-binding protein-like NSN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014813">
        <property type="entry name" value="Gnl3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF30">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08701">
        <property type="entry name" value="GN3L_Grn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="8">
        <location>
            <begin position="132"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="208"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY67557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="707" mass="76619" checksum="CB41AFFABDB4B591" modified="2018-09-12" version="1">MVKIRKKSSKRTTTHMRSKVAKKVSESHRKAKKTAKKDVTWKSNKPKELGIPNSFPYKDQLLAEAAAEKAQAEAEKQARREASRNGTSTTLASTAALAAALAADSQRLEDESAFDEEEGEAQVNDASLKLHAKSLRKVLETSDVLIEVLDARDPVGTRCRAVERELKGLDGGRKKLVLVLNKIDLVPPPVVQAWLAYLRTQAPTIPFKSSTQQQRQHLSASSAHTPTNASGSSTKPLMELIKGFRINPTPSTSTEQKVKHSLTIGLIGHPNVGKSSLINTLKRSKACSVAPTPGWTKEVQEVVLEKGIRVLDCPGVVVEARGEVEGSLRGMVKAEDVRDPKAPIELILQRCKKEHLQMLYNIPAFIGTNGFLLEVARAKGRLRKGGVPDIEGTARSILRDWVAGRIPYYTSPPSVPTLSTTVSVTPVAAATESMGTVTDTDVNQSTLLTEFAPAFDLAALFGEADAVAFGEQGVAGSAVVGKAVKMEGMEVETEDSNVGWVTGEMSEDEDEGGIDVDDLLDDEVEQVDEEGDVSMNVEPTKPTNKKQARSMPTIVSVAPAASNKQKNKSVTFQPSANTVNTKSIVEETQGIGLNKANAKKAKKDKKKLNKVNKEASEFESQFGEEADMVGNKPRKSRVVAGGVVGEAYSFEEFFGKKDGEILQPEDDEEEFYLYDLAPRSLPLASTCFHEFLSLSLGFHATIDRASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PCJ4</accession>
    <name>A0A2X0PCJ4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C005g03327 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C005g03327</name>
        <name evidence="3" type="ORF">BQ5605_C005G03327</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY73919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PCJ4"/>
    <dbReference type="STRING" id="796604.A0A2X0PCJ4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044594">
        <property type="term" value="F:17-beta-hydroxysteroid dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03448">
        <property type="entry name" value="HDE_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054357">
        <property type="entry name" value="MFE-2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13078:SF57">
        <property type="entry name" value="DEHYDRATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13078">
        <property type="entry name" value="PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22622">
        <property type="entry name" value="MFE-2_hydrat-2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peroxisomal multifunctional enzyme type 2-like N-terminal" evidence="2">
        <location>
            <begin position="20"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="MaoC-like" evidence="1">
        <location>
            <begin position="183"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY73919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="316" mass="34234" checksum="AE69E075846A36D5" modified="2018-09-12" version="1">MPIDFEKAIGYEKTLAAVSWNQRDLLLYAAGIGAKRNELTNLFELNKDWQPFPTYPLVLGLKGDSESINNFSKAKDAGGATPGLPALNPKKLVHAEQSIWILKPIPADSGKGWKLRKQSVGVKDTGKGLIVDDSQELVGPDGGVYVRMISSGYAFGDYTKDEPKWKGFQKSIAPKQPTKAANKPPARKPDVVFSEKTTEEQAVIYRLSGDYNPLHIEPSIGKELGFPGAILHGLCSYGHAARALVLNTTGGDGSKLVYMSARFTSPVMPGDELETSMWFSSEGENTRVDFIQKIVQTGKTCLGGGVALFKGKASKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PE95</accession>
    <name>A0A2X0PE95_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C008g05088 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C008g05088</name>
        <name evidence="2" type="ORF">BQ5605_C008G05088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PE95"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="34"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY79254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="354" mass="39171" checksum="099737F73AB6F4F5" modified="2018-09-12" version="1">MGRRHGQSTQADVSVSSLWGPPAARRPFLPNPRGICIYRREHDGHSHYIALYVDDLLLVGPSTAEIDRVLDALELAYGIKRLGPAEYILGIQVKRGHNGSITLSQERYLRDILARFQFADAKPASVPMQPGVVLDFENSSATPEDRTRYLQAIGSLIYLARFSQQPGPEHWTAIKHVLRYIKGTLDLGLTYRKTNQPLHGYSDANWGACLTASRSTMGYAFILSGAAIAWCSKREHRVAKSTTDAEYLSLSYASGDAIHLSELLSELGAPVPGPVVLYGDNQGSLALAQHPTNHQGSRHVRISEHYVRERVAEKEIEVRYIATGDMFADIFTKALGPKPFIFHRTNLGLRGAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PEN9</accession>
    <name>A0A2X0PEN9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C022g09532 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C022g09532</name>
        <name evidence="3" type="ORF">BQ5605_C022G09532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PEN9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ22718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="516" mass="57114" checksum="A47656F9F20D1046" modified="2018-09-12" version="1">MDSVQGIFELLNQTMGPEDSQKWIQRYGTPIVQAILEGREPYRIAIEAIRNAIYPKEGPAFMRQLWTLVGLFSVSVVLTLLGIVLRLRQGRFWLFRRIDCRITMPNISIHNSFWAFVYHCLSIVELVITSKIVSGSSYPSWYISFQCALPLALFAGQVTEVWATFGSSYIRKFGSHHDDPLITTILYQSLPFMFALIALVPSFALLAMLERYLNAVYINADAISTSLGNFSSTWVPGQPVLVSNLEQSLQSLIPLVASMRSLSQWYKIANSYIGCVLGITSVLYILAAVVEITHLRHQSRNLRQRVGLPVVPFSPRKLEDDSQASPTDPPHISGPTADVALRDHLIAQASLVEWAAKNRLLVSTLISVMLLSNTFLSFRIAFTSVSLILNTGDVQAIALIAAWINSVVSFLVATLILFRSLEGSNALTNWLRRVAPYLPIPPTTTTTTRTTSVMRSYIQKPLMGVSIDVSTSVMVSNAKSDESQSENLMPATMPAEDRKATLGSASGSSMDEVEMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PF79</accession>
    <name>A0A2X0PF79_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C008g05378 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C008g05378</name>
        <name evidence="2" type="ORF">BQ5605_C008G05378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY80406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PF79"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY80406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="221" mass="25358" checksum="994D7181119D3F02" modified="2018-09-12" version="1">MVAFKEMLPERNKQYGALAQRYPHFGSLDRAVTTAAPLEIGSLICFGLKLGSWRSNCLCRRSAVHRNYSVRYIYSKMTTARSRRWFYFQNVVAQELRLIKKACFSTHLIDGTMPFRMICGRQVIDSLGVPKTTYSLTTDLTSCYSDVRIISTSAQAEEQYAALRSQKGSLTTKQRASQQSKEGLFEAWSHAQHQPKRRAPQATFDRPPRARKRSERVFKAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PFP1</accession>
    <name>A0A2X0PFP1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C009g05599 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C009g05599</name>
        <name evidence="2" type="ORF">BQ5605_C009G05599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY82842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PFP1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY82842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="68" mass="7140" checksum="CF0DD0655D1D919C" modified="2018-09-12" version="1">MEGAGRVEKEDRTTAVQPINNITNNTSVVAPSQSLGTDTLESQNRFAGLEVEGKPGPCSRAPTTTPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PFQ7</accession>
    <name>A0A2X0PFQ7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C039g11784 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C039g11784</name>
        <name evidence="1" type="ORF">BQ5605_C039G11784</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000060">
        <property type="protein sequence ID" value="SGY90015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PFQ7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY90015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="290" mass="29787" checksum="AF7545072E1ACA66" modified="2018-09-12" version="1">MPFYYAHVTSLAGRCSRRARPDFALRSIASPHPCDAYAYAPHLDRLFISQPKRSRRSLRSRSVHTTNPCMFYAVITEPDSFLSAPALARPPRSCTVQDTLSTIIPGTCSTTCATWLTSLGACPSTPATTAATTDYNTCVCDTAFVTAFTTCSTCITTALTAASDPQLALPATALTDLTAYCATVAGGTAAATTTTTTAAATTATTAAATTAAASATTNVASSVAASPTVSTSSATPFNTTPTVVIVTSVFQGQGFPTQTKSTNVFTGDAQGRVQVTLGALLVAAGAVWFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PHN3</accession>
    <name>A0A2X0PHN3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C034g11286 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C034g11286</name>
        <name evidence="1" type="ORF">BQ5605_C034G11286</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000065">
        <property type="protein sequence ID" value="SGY99473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PHN3"/>
    <dbReference type="STRING" id="796604.A0A2X0PHN3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017264">
        <property type="entry name" value="Ribosomal_mS37_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28066">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28066:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY99473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="101" mass="11059" checksum="946B1A9E52DBF9B3" modified="2018-09-12" version="1">MVHIPKVSPINYIQHSNDPTHPSFSPPAVPPQLKVKPRRTAHIQPCAIELSAMLTCWAASGDLASVDKCKESAAKLHECMQKPKIGGKARAPTINYHLSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LNG4</accession>
    <name>A0A2X0LNG4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C096g13095 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C096g13095</name>
        <name evidence="1" type="ORF">BQ5605_C096G13095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000010">
        <property type="protein sequence ID" value="SGY11645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LNG4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY11645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="50" mass="5540" checksum="86BA58EC5F20829F" modified="2018-09-12" version="1">MNASACSLYASDSANNENCYYEVIDASAPSCHYIDADFTPLPLTIQQKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LRG5</accession>
    <name>A0A2X0LRG5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C013g07225 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C013g07225</name>
        <name evidence="2" type="ORF">BQ5605_C013G07225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LRG5"/>
    <dbReference type="STRING" id="796604.A0A2X0LRG5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007149">
        <property type="entry name" value="Leo1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146">
        <property type="entry name" value="LEO1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146:SF0">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN LEO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04004">
        <property type="entry name" value="Leo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY15051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="538" mass="59542" checksum="33EF6E73D5C22F5D" modified="2018-09-12" version="1">MDLDHDPSQADALAEALGTRTTERAFPASDSDAAKIVQEHQAGQEHDQDDNDGDDDGDEDGDEDGDEDGDQQEDGNLSKDLFGDDDDDDDDEPAEADPTTTTEAVPLPELFSDNDNPNEMNDFIDQDDQALTPEEAARRRQLEYGERTPSPGTFVTKTETKVALPLANLDVPQGGKVWHARLPHFLGLETQPFDDLMWEPPAAKQAHEIMDENVIRWRWSKHELDQVIKESNARIVRWSDGSLSLQLGSELFDMSVALDQSALLTSSSSTIPVMPSSTTSLSLTTSSDRAHGLTYLVASHDYTELLEAQASVHGTLTFRPTTLQSATHRKLAGHIHARNLKSVRTKIADLPAFDPEKLKAQRERLEEDKRKKAHKERKKAQGGVGPRGGRRNRGTVRLEGIEFSSDEDGEDGGIAGGRGGAGRTQPKRGRGGPLAQDYDDDDDDDDGFIRPDDEEEEEGEGGQQDDDDDDDDDDDERMDVDDQMERAEKAMELERRKKKEEKRLGHSAGKDTQASNNEASEPVPAPRRRLVVESDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LS51</accession>
    <name>A0A2X0LS51_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C012g06855 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C012g06855</name>
        <name evidence="8" type="ORF">BQ5605_C012G06855</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LS51"/>
    <dbReference type="STRING" id="796604.A0A2X0LS51"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009383">
        <property type="term" value="F:rRNA (cytosine-C5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF30">
        <property type="entry name" value="28S RRNA (CYTOSINE(4447)-C(5))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="80"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY16357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="142" mass="16247" checksum="A0289EC51A110B9F" modified="2018-09-12" version="1">MTEENEAVVSYALRKRPHVKLVETGLQFGKKGFKSYKGKVFGKNMHLTRRFYPHVHNMDGFYVAKFKVGKPDKKAIALAEQEENEVSEYKPLGEEEDEDEDGKGEPKFDDEQDEALIKESQKRYLKKKGVNPKALNGKPSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LT20</accession>
    <name>A0A2X0LT20_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C011g06260 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C011g06260</name>
        <name evidence="6" type="ORF">BQ5605_C011G06260</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY11750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0LT20"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019783">
        <property type="term" value="F:ubiquitin-like protein peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="5">
        <location>
            <begin position="111"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="335"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY11750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1537" mass="169184" checksum="13D36A52E22781F6" modified="2018-09-12" version="1">MSLPPTHAFLATDALINARKQGYRSLAVGSTCLPLGADRLWSEYDRAKDVQSWALRAQRWMDKIIVINEIDRNRIAVARRILNGLQWQEQDGLLPLPLLASGTSLVYLLRLLSQQLAYSRLYPGHDWLGEAAVNLSIESVLRAGRVQNPDFETSYGLIPSTVISLVMARPPDSDPHSVFKACFFGPPNQYRNLIELGDCMRNTPTSKSIWFLPLCSDSHWVLARINMHKRTWSVINSLSATPITAATRTAVLTLFKFLKLDIRNEFPHTPKAEQQEDSYSCGPATINAVETEVLGIGSFNAARAHMSRLRQFCRLSSLVGAVEDPKEIESIVATGAKSKAKSGRGSAAGTLSSKSTSAESGKAATIKPTNQRVASSSKNPPTSRLQTTFTKHTTWARDHPPLFRRFAEKVEDLCPGSNVDVNNPKYVRCGRCYVLVPMAALLCKARFQLHLGNKKCVNLQPISNFFRPIASGSTATSPSLGPCPGLTSETAMHYLSPTAAQGGGAPPRRTLCLRLYPKIGKRPMTELERKEVDRLEANEWKWRNDHRAPRIISVNCRKYSARDSINKDGPSLPCEECARLPKDSSCRAALRRQYAAGATRKYTNKKYVAGDTLLSAIYRRHHGLEEILDDNGQGIVYLRFAQGVASGEFDGANILEGLVNAATVKHDRMVKGKSMRGFVRSEALRDFEQAMALASPMALRVLQATIGASTSRKLQMRLGLDKSNMDRVCAKLEADGLTFNLHVDDTKCRSRMRTTPYYSEDLSLEREIRTKGIFRHELIGSIGPPRIYETPGELPDMFSGPDPPVAGTKIRAYMIAPNDVGSPAQVFAAFVIGETTNAEDATEQSHSVIQELIKRCVAHLLVSISADGAASEGVLQRNVAVLLRDQGGAVAQTGSRNASSYTLPSPDPDGVFPEITISTVNVAGTPIVFCRDEKHLAKCLRNAIDSGARLLFGGLGCIAYQDMLTILGGLESRRTLSRRDVTKNSTPMRSYISSYVASYTMPSRTGRFSPLNVSGCCSLSDIRSRRGMTLSEVAPDLALTRSSPKKRLMGSGRWLTQRLLSSATTEIFGRRNRSFPGGMAQKWWSTSSGVYARLIRQATGKVTALLELMRKFKTEAAGSRQGYHHTYNDLNDLDLVAMRTYPSDGDISLTSFAAANTARELLSGLRMWEPVQRIASNRRNQGPQPDILVEDVLAHGTTVQGSSERLGLQVMHHHPTKEDQGLLRTEMLDSALDGMRRSTCQGVVKLDPNEREAVDRAIRSLAALDFDVEAALLDVQIAYDEADRQAEERYVLETIEKANSSLRPIPTHLKLPPLVDARDTSFSLNWASLIAHRAAHECSHLRAVLLKGRPMELSDTSRGEAGLEISNTEQGRSAVHSRVLKGLVQSTGPSRFEDIAGTARSFRWTGGGQVARALTTNEIQKNAYIEDGRIQEKLPERDKQYEALAQRYPHFGSLDGAVTAATPLEIGSLICFGLKRGMHSLSCDQTAYGEEALSIGIGTFDNKPLQPRHARLVGSTLKCRRTGASPHQENMLFHTPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LTU2</accession>
    <name>A0A2X0LTU2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C011g06622 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C011g06622</name>
        <name evidence="8" type="ORF">BQ5605_C011G06622</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LTU2"/>
    <dbReference type="STRING" id="796604.A0A2X0LTU2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008506">
        <property type="term" value="F:sucrose:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432:SF35">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 45 MEMBER 3 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="501"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="543"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="594"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="619"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="843"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="202"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="653"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="719"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="101"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="653"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="667"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="738"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY12833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="890" mass="96165" checksum="FF7E219568EC31F3" modified="2018-09-12" version="1">MSSRRASTRSSRGSTGNNNGTSRRISSGPPTATTPTTPTTPTLPAHHTTYESFADLVHIGSAPPQHASPKFAPSSLSNATSNLWNRSSPHRPGAGGRAHKNQNQPTTTTVTNTTPHRESSTSCSASSPSSNRRTRVASAITLPGSRRPLTAGPPRTAPIGTPPHREEEYYASTGERLAAGDDDDEEEEDDDTSCRRVAQGIMGYKPQSHQPHPTRTNPDKHPLDHTGTGTSSSTPDLTTFDLVKLTLGLAGAQLAWTVEMAFGTPYLSSLGLTKRATSLVWLAGPLAGLIMQPSIGALSDASKTKYRRRAFIAASTASVVVSTLFVAYANEIGSLLSGWSGLGDWDPKQEDHVRASAIAIGVLGFYVLDSSLNGLKASLRALILDQPPRHQQNVANAWHGRMTHFANIFGYGAGYIDLGHWAALSWVGGGQFRKLAVMACVVMTLCVAITCWTQVERISSSELQIANRGIRWSSIWINVRKATRELPLSVRRVCYLQFFQWTAWFPFLFYSTSYVAEVLYASLPPDQEEPSTDTATRAGSLALLLYALVSLGSGSLLLWLTTLGRRKIVNRRLSRTSKKGRLMRHLLANMTPRNMWTLGTVLYASAMVATFWVKTVEGAMSIVAFCGVSWAVQCWVPFALVMESIREIEPASAPTASSLPSSEDARTSPSQAPSQTNYGSTHFDRGSKKKPFSPPPPPFAHSSSQLERVRQGLAECSPLLSSRPEGVSRGSTRGSQGRIEERGHREAHSDPAASNSSSTAGGTILDIHNQACCMPQFFVAVVAACIFSLLEKERSVNEGNGKSTDLVLRRGLELLVSTFASEGGGGSDSEPTDGLRGANDVVWVLRFGGLAALVGVFFSRYLLETRSEAEYKDQVLAWPFQLVEEEEAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LUW3</accession>
    <name>A0A2X0LUW3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C017g08507 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C017g08507</name>
        <name evidence="2" type="ORF">BQ5605_C017G08507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY20173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LUW3"/>
    <dbReference type="STRING" id="796604.A0A2X0LUW3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000823">
        <property type="entry name" value="Small GTPase RAB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY20173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="219" mass="23614" checksum="12F8BB27FA88DADE" modified="2018-09-12" version="1">MSSSTLTSNPSPPPVTSSRKLVLLGESAVGKSSLVLQFVKQQFDDYRESTIGAAFLTQTVAVQNGFIKFEIWDTAGQERYKSLAPMYYRNAHAAVVVYDITSAPSLQKAKNWIAELQRQADPGITVCLAGNKLDLAETQRQVAYEDAAKFAEEENLLFFETSAKTAQGVVDMFQKIADKLPLDLPSAKARTGAATAGGARLGVNLNNQTDNTSQGPCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LWS7</accession>
    <name>A0A2X0LWS7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C018g08703</name>
        <name evidence="12" type="ORF">BQ5605_C018G08703</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 8">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY26134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LWS7"/>
    <dbReference type="STRING" id="796604.A0A2X0LWS7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="10">
        <location>
            <begin position="50"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="11">
        <location>
            <begin position="277"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="465"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY26134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="496" mass="54210" checksum="E1BC4A3CA4614BC1" modified="2018-09-12" version="1">MREIISISVGQAGVQIGNSCWELYALEHGLSPDGRIADEEKVNPNEQGGFSTFFSETGSGKYVPRSIYVDLEPSVVDEVKTGKYKRLFHRESLNSGRRGSPAGSDLTRLCPPPRLSLAESLITGMEDAANNYARGHYTAGKEVIDVTCDRIRRLAEACSGLQGFFVFHSFGGGTGSGFGALLLERLATDYGKKAKLEFACYPAPNLSSSVVEPYNAILTTHTTLEHVDCSFLVDNEAIYDICRQRLGVQSPGFVNLNRIVAQVVSSITASLRFSGSLNVDLNEFQTNLVPFKRVHYPVAAYTPLTAASKASHEANTVAELTNACFEPSNQMVKCDPRTGKYMACALLYRGDVVPKDVNAAVASIKTKRTIQFVDWCPTGFKLGICNEPAQCVPGSDLAKVSRSLCMLSNTTAIASAWARLITTSPISSLTRNSDRKFDLLYSKVGRVLRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEELGQEADGEEEGDVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LX13</accession>
    <name>A0A2X0LX13_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C015g07868 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C015g07868</name>
        <name evidence="6" type="ORF">BQ5605_C015G07868</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LX13"/>
    <dbReference type="STRING" id="796604.A0A2X0LX13"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004392">
        <property type="term" value="F:heme oxygenase (decyclizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006788">
        <property type="term" value="P:heme oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19165">
        <property type="entry name" value="HemeO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002051">
        <property type="entry name" value="Haem_Oase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016053">
        <property type="entry name" value="Haem_Oase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720">
        <property type="entry name" value="HEME OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720:SF0">
        <property type="entry name" value="HEME OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01126">
        <property type="entry name" value="Heme_oxygenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY17712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="404" mass="43836" checksum="9844D5833622542F" modified="2018-09-12" version="1">MLSILSTVTLPSGSSDGDRRRSDSSPDHSQATAANGTSDINAEAITNPPASLPSTPPVLAVSELLPTSLEHDHPVNDSPAWGLATRLRRATAQAHHDVMLPRVVHRLSLGDLPLPVYIAYLEALSVIYESLERYLGLNATCEVLSPTYDPATLARSAAIEADLSYLTLKLPRANRTPSISSGRNWPSVKLYAERLHCLGSGNNGLPHESSGLAIAAKVAQERPALLLAHAYTRYLLYHAVGDLSGGQSIARSVRHAYSLPDSGEGSQFYQFFPSSHPRRAGVFERANIQEIRDLKFWFRAGLDSAGRATTNELAKAIEEEAKVAFKYNADIFSDLELCLGQFESAVSDGDKSVAESTPDEKGTLPPVWMLGSNALTRTLTMKLTISLVVLLAYVISMIYIKPRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LXB0</accession>
    <name>A0A2X0LXB0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C080g12973 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C080g12973</name>
        <name evidence="2" type="ORF">BQ5605_C080G12973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000035">
        <property type="protein sequence ID" value="SGY28325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LXB0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY28325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="200" mass="22142" checksum="D12D064E9D93A2DC" modified="2018-09-12" version="1">MSLTDLPAADVNTMAGPDDRASTPPPSSTSTQSQNIDVSAIGSITLTREQYEELVRYQRTRDEEAPTPRHLPPEAPAAFPEDSKLKGDNYVDWDITMSLTVDREVCAYLRRGTIDPTWTPTVRSRWQDYALHVLARSLTPATKATIGPVVQRGGSAHDCWLALTARYAPSDAQGHSSLIMNYFGMPQCPSTWKGFIDWSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LXZ6</accession>
    <name>A0A2X0LXZ6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C014g07603 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C014g07603</name>
        <name evidence="10" type="ORF">BQ5605_C014G07603</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NiCoT transporter (TC 2.A.52) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY19283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LXZ6"/>
    <dbReference type="STRING" id="796604.A0A2X0LXZ6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015099">
        <property type="term" value="F:nickel cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004688">
        <property type="entry name" value="Ni/Co_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011541">
        <property type="entry name" value="Ni/Co_transpt_high_affinity"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31611">
        <property type="entry name" value="HIGH-AFFINITY NICKEL TRANSPORT PROTEIN NIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31611:SF0">
        <property type="entry name" value="HIGH-AFFINITY NICKEL TRANSPORT PROTEIN NIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03824">
        <property type="entry name" value="NicO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0533">Nickel</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="319"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY19283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="503" mass="54809" checksum="40D03F5468D46B6A" modified="2018-09-12" version="1">MVSSLSKEAIDPLPSTSSSPNPGDRPTPARPSEPSLIARLQHEKIRRVSLFGRSVLVLVGELVVNVLLWGVALALFVGDQGRRGILSLCLIAWTLGLRHGLDMDHIVAIDNVTRNLVALGRLPVTVGLFFSIGHSTIVVAATIAGCMLNLVISYISIVIATSAIDKMDNVSAIGGVIGVSISASFLLLLALINSAILFATLREARKRRNVAAAAATISTVDVPETPSKDLEAQPDFRATSPTPPAAPTRLPTTTCLTRLGRPLFALINRPYKMYFIGVLFGLGFDTASEITLLGISALARRQSISSDGSLRAGIKTSEILILPLLFTAGMTLVDSIDNIGMCWGYSWERFREKKRWKWWVREGEEESVELGVLGTADEEGLLRISTVLTILSIVLALLISITEFMGLALEKCTACAQAAETSPNLDGRWWRFWGTANDNSGYLGAGIVALFIVVFASWYFITWGLRKRCQRKHLHSDEDEKTEDIEGVRVTEHVEVPYSSPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LYP1</accession>
    <name>A0A2X0LYP1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C002g01393 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C002g01393</name>
        <name evidence="1" type="ORF">BQ5605_C002G01393</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY32650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LYP1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY32650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="264" mass="29716" checksum="6594AAC3A3D05684" modified="2018-09-12" version="1">MAIGLHPGHSLLEDEYWAHKPVMVKLRCPTCAAGGLCGTPVAFTQDLIRCNLCGLYLHKLHAEISKEEQRTTRCIICVNVVSTKDLRADEFKKLSGIVSLARSCAWAYISEAWRLVKVHDYGVPRDGLGVRALAEVSCPEESVNLRLVPGNKLAWSFSNAKQLAGSKNREIYLSLQVPTEAILKKTWSTNSSLMKTFIKDTKKTIKHLNKLAAERYADNDSDEDGPVRHHYFPMLQKWYLFAMPLVQIIQSEPEEVTGWAYSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M0J0</accession>
    <name>A0A2X0M0J0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C003g02058 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C003g02058</name>
        <name evidence="3" type="ORF">BQ5605_C003G02058</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY38663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M0J0"/>
    <dbReference type="STRING" id="796604.A0A2X0M0J0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041320">
        <property type="entry name" value="CxC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18802">
        <property type="entry name" value="CxC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxC1-like cysteine cluster associated with KDZ transposases" evidence="2">
        <location>
            <begin position="16"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY38663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="492" mass="55532" checksum="11645127FA1293DE" modified="2018-09-12" version="1">MPPKRRYKSKLSVYKLQVTFCASESRCATDVERLAQLGFISSTASMPMTAFSFRLVEQAHASWKVSPRAITGYADGLKEYYSRCGGGRGHYTGHPWTFGSNAIDEYRALETCEEDSGDLLAGIVDSFQQVSRVLRANQTREKNSNHDQIIPDTFLAEEEVQAMKAEVEASVRPTKKVSNAAFCICLNGIAYLYTHPPSSYYALAILKHISERLPENAKIGFLIDIACNFKHHIEKTKCAYFLIICHQRQLLPKLFKRLEFATSVFHAYTHIWSCQVEFNPRLILNFGLTDGEGSVRAKDRVGEEKARIGAEVRQALAWIEDEKTCSTSFQTLWTNISDTLPELIDPADAESIFGAEDVEEIRDRALIILDRRMELLQLRECSWSQNDHFFNVWLDTRGQSEGDSEPMRPALSEFRGLHQRLNATGRIVEKAKHHQLSARNRSGTRGPMETSGLDSARPAPLARDVQQVRVIQAQMDMSDETQLAKEVGPFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M0P3</accession>
    <name>A0A2X0M0P3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C003g02108</name>
        <name evidence="12" type="ORF">BQ5605_C003G02108</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY38952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M0P3"/>
    <dbReference type="STRING" id="796604.A0A2X0M0P3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044444">
        <property type="entry name" value="Ribosomal_mL44_DSRM_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207:SF32">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="RIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22892">
        <property type="entry name" value="DSRM_MRPL44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="11">
        <location>
            <begin position="242"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="10">
        <location>
            <begin position="435"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="42"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY38952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="531" mass="55947" checksum="415798CE56E0A5AD" modified="2018-09-12" version="1">MSRSALHSVRTWSTTATTTATQATTCTSRHCALASSASSIELGRRPSNKIAEPTLPSRLHPQQVHSRSFSSASTSAAAAATNASTSQASPRAYISPRPHVPREVRRTTNSNKKPPSFASARDVGPGSTHTASDLPTPPPTPSETAEANDSYILNPLTDQSLSLLFTYTTPPPLSSLSAFAGRLATSVVGAGKHSAQFSLAQDLALLEQCLIHESFWAGVNTLPKSNAAERQHTHFHDSPISAPTSVTALRAHNEPLASLGNALLGSLTAEALIEQFPNLPTRVTKAALTMFVGPKSLAAVATSWGIAPTRLDHRWVGRPDAQKLSGKDRAYGHLVGGIGPAAKRESVGGDGAAGIGLVRWNRTKVSLLKDAVLFEDALASVARAVVGAIHQTHGFNAARQFAHAHFLASLISSTNSKLPSPIASSQILPLLKFTNPTSVLSSHLVLKASAERATHRLLKESGRLSNHATFVSGVYSGATKLGEGFGSSIKMSEYRASEDALRRLYLSGKGAKGTRVVGSRDWDKRGSGVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M282</accession>
    <name>A0A2X0M282_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C002g01070 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C002g01070</name>
        <name evidence="4" type="ORF">BQ5605_C002G01070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY29620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M282"/>
    <dbReference type="STRING" id="796604.A0A2X0M282"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01882">
        <property type="entry name" value="BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037875">
        <property type="entry name" value="Bms1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF2">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BMS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AARP2CN" evidence="2">
        <location>
            <begin position="279"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome biogenesis protein BMS1/TSR1 C-terminal" evidence="3">
        <location>
            <begin position="754"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="647"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="747"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1200"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="661"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="747"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1220"/>
            <end position="1250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY29620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1256" mass="141228" checksum="5F67AABB30D519B8" modified="2018-09-12" version="1">MDGSKQTNRAHRPSKAPKAGPAKGQNPKAFVPSSFRRAEKQGRRNVEKDQTRLHVPAVDRTFGGTSGQGGKDVEGEVPPVIVAVIGPQGQVGKSTLVRSMVRRYTKNTLADIKGPVTVVTGALQLYSRSKLSFEPTDPHFRHPAGKNRRLTIIECPNDLGSMIDVAKVADLVLLMIDGSFGFEMVSCRTCHTLYCSTFNAASRLSPLAPQETFEALSALSSHGMPKIIAVLTHLDLVKTPAALKAQKKRLKNRFWTEVYDGAKMFYLSGVMNGRYPDREILNLSRFISVAKFRPLVFRNQHSYFLADRFDDLTSRETIRQNPKTDRTLALFGYLRGVPLRPPGPTHSLRVHIPGAGVDAFQVSRLLELVDPCPLPTKDSEKRRKMGDKNKVAYAPMSGGSATGVMWDGDKVWINTSGTFSKRREGDEEYDPEDDTDQVGGDGIKMMMELQDVPETLGDGVAASQIRLFGSSKQPLQVPPLRINPHDPSSSSSSSSLKRTRRAAFDDAVGEHDGADYEDDEEEEVEVDEDDFDTDSEEEEEEEEEEDEGMKFEKVGSSEVRTGRRVAGGPTSVGERGEKIAYADSDSDLGFGEEEEGQLNLEEDEDSDEEEEEGPEWKKNLASLAAANWGQRRKPNLMKLIYNSTFSAEEIASGRTDKPNNDDDEEEENIQDDDDDLFKISRKAHLDENGEEEDESAPEDRFRRPVSNAELEVWQDEDFLDSIRHLFITGGAADSSVATGANAYEEEGGDFEDLENEEGSSKPAADSVQEDSKTKADRLAAKKADLKRKFDAEYDHDSDDEDKMDFYTEQKDEMERKLRATRAEFAEDDAETRALVEGHRPGTYVRLEITGVPYQMVENFNPRIPIIVGCLLAHEESFGYVQVRIKKHRWFPKILKTNDPLIFSLGWRRFQTLPIYSLDDGTRNRMLKYTPEHMHCLATFYGPISAPNTGFCAFNRLGNDTPSFRVSANGVVLDINGATSIVKKLKLTGTPYKVFKNTAFVKDMFTSSLEVAKFEGAHIRTVSGIRGQVKKALSKPEGCYRAAFEDKVLMSDIVFLRAWYQIKPRQFYNPVASLWLRDKASWQGMRLTGEVRRDQGVKTPSDINSLYKVSLRGPSGSERAVSVLKVSHLVLLQPIVRETRRFNTLKVPRKLQAALPYASKPKLQTPQKNKTYMQKRAVVMEPDEKQALSLLQQIQAISRDKLAKRKEKKAETKEKRQKKLAKIDAGRAEKEKEKKQEHFKMQENKKQAQERKRQRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M305</accession>
    <name>A0A2X0M305_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipase</fullName>
            <ecNumber evidence="5">3.1.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C002g01360</name>
        <name evidence="9" type="ORF">BQ5605_C002G01360</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the phospholipase D family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="5"/>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY32400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M305"/>
    <dbReference type="STRING" id="796604.A0A2X0M305"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09138">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016555">
        <property type="entry name" value="PLipase_D_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF186">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009376">
        <property type="entry name" value="Phospholipase_D_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016023988" description="Phospholipase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="8">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="8">
        <location>
            <begin position="727"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="622"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="624"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="645"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR009376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY32400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="947" mass="106913" checksum="C3E2FBDC0A2D3660" modified="2018-09-12" version="1">MNGFVSLLYFVRCFLNLCAEIIVRGLTVLECELDARALGPIKAMGLRRAHLRHVSALHPSLWHASARPFVPADTTLFQLDKMSGFSSKFKDLKSSIDTSKFKDIASSVEKLTSSMEKMPGRLERLGESVRFAYNPNHRHDEEHEREEDRIRAEICAAHRFGSFAAVSNDNHVKWYIDGHDFFHTVSEILEGAQDSIFIADWWLSPELHLRRPPAANEDWRIDRLLLRKAQAGVRIFIIVYKEVTQSMALSSAHTMHYLMDLHDNISVMRHPDHLGGEMSLIYSHHEKIIVVDAAIATIGGLDLCFGRYDTSAYPLADVHLTDFKHTLFAGQDYNNARIQDFAQVDHWLSNSVSRLDTARMPWHDCHSCLVGPAVLDVAQHFVERWNFIRDLKYSKNKRYPMLSFPHVIVEGQEPEPAIVRHPHIDRFKRFGENIVRNPITPDAEATAALNMRVQVLRSSADWSHGILPESSIQNAYLQMIAEANNSIHIENQFFITSTTDKGPIKNLIGKALVERILSAARSGRKFKVTVILPSIPGFAGNLNGNSGLLAIMHWQYSSICRGGNSVMELIAKEGFDPHEYIGFYALRAYDRLPDAGRVKQMEQRSGVDFNTAQAALARVFMGREPPKDELRDNQELSFASAEEGGEVKALDPREKKKPETGPPVDKRSLPQSYQEALETIQQFEQGDVVREELADSISHHVFQGTGSLLDEPWFGTEESERKAYISELVYSHLKLMIVDDRRVIMGSANINERSMRGDRDSEIAIVIEDTNMIPSRMDGQPYMAARFAVTLRRRLWRLHLGLAEPTLFPKGSAATPETVTAAMLPPDVPHDDETESTEDALVADPLSDETIALWQGTAKRNAEIFEEVFHCVPSDRVHTWNEYKAFVPQAPVKPGHVADPNMSAHEIKTKLDQVRGHLVPLPLEFLDQEKLLAMDAAVNPVTLDIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M500</accession>
    <name>A0A2X0M500_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g03766 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g03766</name>
        <name evidence="2" type="ORF">BQ5605_C006G03766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY53506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M500"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY53506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="133" mass="15257" checksum="0D9216DF7C4D444A" modified="2018-09-12" version="1">MSHRSSKTAINLASRAHRRQAPEVRRPPLSIVVNRLQRPKAFLKTIRPIKKQVAKLGIPAEQYLQISQVQESPIRIRSEPTLVDHDHWTTQEVQVNAVREKVPSTEPTRSVWSKIRTDAVSQVSKATDKVNYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M5H5</accession>
    <name>A0A2X0M5H5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BQ5605_C003g02272 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C003g02272</name>
        <name evidence="12" type="ORF">BQ5605_C003G02272</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase IV family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M5H5"/>
    <dbReference type="STRING" id="796604.A0A2X0M5H5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00922">
        <property type="entry name" value="Cyt_c_Oxidase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.442.10:FF:000002">
        <property type="entry name" value="Cytochrome c oxidase subunit V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.442.10">
        <property type="entry name" value="Cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004203">
        <property type="entry name" value="Cyt_c_oxidase_su4_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036639">
        <property type="entry name" value="Cyt_c_oxidase_su4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10707:SF10">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10707">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02936">
        <property type="entry name" value="COX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81406">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY39757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="169" mass="18316" checksum="616BD5AE140D8891" modified="2018-09-12" version="1">MLSRQFPTLGRQLRRSSIRCASTTASTPATSSASPVPLANRIEASWKGLTPAEQESTFKALEELQKKDWTQLSIDEKKAAYYVAFGPHGPREPILAPGSGAKTLGGVTLAVIVSLGLFTAARTLAQEKPKTLSREWQEASNEMAKEQKMDPFTGVTSEGYKGKGFVNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M8A1</accession>
    <name>A0A2X0M8A1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C001g00757 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C001g00757</name>
        <name evidence="4" type="ORF">BQ5605_C001G00757</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY49241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M8A1"/>
    <dbReference type="STRING" id="796604.A0A2X0M8A1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017176">
        <property type="term" value="F:phosphatidylinositol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013234">
        <property type="entry name" value="PIGA_GPI_anchor_biosynthesis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13692">
        <property type="entry name" value="Glyco_trans_1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08288">
        <property type="entry name" value="PIGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="447"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="PIGA GPI anchor biosynthesis" evidence="3">
        <location>
            <begin position="90"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY49241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="523" mass="58179" checksum="81E06F1B82532F92" modified="2018-09-12" version="1">MGSQPRSGPSPAPAVRRWDQPSPTRRKRTRDRPLNIAMICDYFFPKVGGVESHIYSLAEALAQLDHKVSIYRVPFHLALPDLVLVIIITHAYPPRSGIRYLPYGLKVYHIPVQPLPPTHVHATLPGFFTALPYIRNILIREQIDVLHAHASLSAEGMEGIFHARTLGVKAVFTDHSLFGLGNMAEIWGNKMLKGCLSDVEAVICVSHTGKENTVLRGALNPSIVHVIPNAVVASHFKPAEPPAPVPETLTIVCLNRLVYRKGIDLLIAALPRVCSMHPDVRVLIGGDGPKIVELDQMLDKHQALLRDRVELLGAVRNGKDVRDLLSRAQIFLNPSLTEAFGIGILEAACAGLFVVSTRVGGVPEVLPPGLVEFAEPDVEDLIRAISRAIHHVRSGKHDPLAAHDQLKEIYSWPDVAERTEKVYYDALEVPEVPVVERLRRYYGTGLIFGKMLCIIICVDYILLAFLDFFFPREDIDLVPKFELSRWQDLCKEELERTEAEREELKRTKAGGKSGDGRENSSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MB90</accession>
    <name>A0A2X0MB90_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar calcium ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C005g03675</name>
        <name evidence="12" type="ORF">BQ5605_C005G03675</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MB90"/>
    <dbReference type="STRING" id="796604.A0A2X0MB90"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00846">
        <property type="entry name" value="caca2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF22">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 10" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="282"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="411"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="95"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="287"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY77585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="429" mass="45971" checksum="553151E6A4292A2B" modified="2018-09-12" version="1">MAPSNNNSGERDALLGNNNNRQHTYHVSAVPNAVSPNPAYLPIPQDDLGNGAQGDIGVVASLKALLFSGWLNILLVAVPLSFISHFARWGATADFIISFIAIIPLASLLGDATEQCALKLGQTLGGLMNAVSYAVEAIVGILALTKGELRIVQTSMLGSILSNILLVLGCSFLAAGYKFKESNFQVTAAQASSSLMVLGTTTLVIPAAYHVSRKEANGDSFTTLLTAVGDKTKDFDGLLTISRGTAIILLVCYAFYLLFQLKTHAYLFEDPQDHEEEEAKMTVTTAVASLCIVTVITSFCADYLVGAIDEFADQYKIPKSFIGLILIPIVGNAAEHVTSVWMAMKGKMEITIGVAIGSSIQIAVGVIPLLVVVGWAIGQNLTLYFETFETIILFISIYLVNCLVQDGKSNWLEGMMLVALYAIIALSFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MB92</accession>
    <name>A0A2X0MB92_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C010g05952 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C010g05952</name>
        <name evidence="4" type="ORF">BQ5605_C010G05952</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MB92"/>
    <dbReference type="STRING" id="796604.A0A2X0MB92"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008277">
        <property type="term" value="P:regulation of G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02987">
        <property type="entry name" value="Phd_like_Phd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001200">
        <property type="entry name" value="Phosducin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051499">
        <property type="entry name" value="Phosducin-like_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024253">
        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052:SF1">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02114">
        <property type="entry name" value="Phosducin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00677">
        <property type="entry name" value="PHOSDUCIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosducin" evidence="3">
        <location>
            <begin position="182"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="113"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY13708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="347" mass="37528" checksum="C7A56390F431E088" modified="2018-09-12" version="1">MDINDQFGGDAVAAEAAFVDGTHPALAGNGASAGATSARQQHRRHDSGSSAASSSSTTPRRALPRSPTSPSTAQDSNNAVHAPRRSNAANGAASQTGPKGVLADWHALNEAGVSATSNTGPKGVLKDYKSSQQQQQHPHQQIGLHNRPPSPTARMMAAAYSLDLDGHDSAGGEHDVRLLVGDEAARELYRRQRITELMGSGERKETKQKRKFGHLREIGFEQFVAAVEDEADDVAVVVHLYEPPPQDIEACTQLNTHLSSIARSYPRTKFLRALATDLDFAANAEEHALPTVLVYRGGELETSLIRFDQEWDQGTRSDVIQLLTNCDAISGSPIMRSRFDRFTDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-05-29" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MD17</accession>
    <name>A0A2X0MD17_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C004g02708 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C004g02708</name>
        <name evidence="5" type="ORF">BQ5605_C004G02708</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BUD31 (G10) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY66806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MD17"/>
    <dbReference type="STRING" id="796604.A0A2X0MD17"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001748">
        <property type="entry name" value="BUD31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018230">
        <property type="entry name" value="BUD31/G10-rel_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411:SF0">
        <property type="entry name" value="PROTEIN BUD31 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411">
        <property type="entry name" value="PROTEIN BUD31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01125">
        <property type="entry name" value="BUD31"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00322">
        <property type="entry name" value="G10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00998">
        <property type="entry name" value="G10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY66806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="186" mass="21277" checksum="22F6F8B274848A17" modified="2018-09-12" version="1">MPKVKTSRTKPPPEGFDEIEQILEDYQRKMRDAEAESHEGKRKTESLWPIMRITHTRSRYIYDLYYKREAISRELYDWLLKEGYADAKSVLLLSFEPRTGSGAECLIKCLLRILFSSLIAKWKKQGYEKLCCARCIQSRTLLCACASQDMNYAGSTCICRVPKAQLKAGVVVECTHCGCRGCASQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MD65</accession>
    <name>A0A2X0MD65_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C012g06707 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C012g06707</name>
        <name evidence="2" type="ORF">BQ5605_C012G06707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY15937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MD65"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016073886" evidence="1">
        <location>
            <begin position="23"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY15937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="166" mass="18847" checksum="D10E1B2AFF37FAC3" modified="2018-09-12" version="1">MAPLWFLSCSSNFLVWSPLVLRSETYHRLSRCVTSNFLVWSPLVLRSETYHRLSRRDNFIAVGELAKAKGGSRRAQAIQLSQKFYRLPLYLGQRPQALHLLQAFKHFNLGHLFASALFSPRAPFHSCHPRDLGLPAPRTSSPRFGTCTALFSSNYTLTTLLPPTLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0ME94</accession>
    <name>A0A2X0ME94_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C004g03088 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C004g03088</name>
        <name evidence="10" type="ORF">BQ5605_C004G03088</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY69993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0ME94"/>
    <dbReference type="STRING" id="796604.A0A2X0ME94"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF16">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="59"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY69993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="516" mass="56689" checksum="98A1AECA8506C8EA" modified="2018-09-12" version="1">MVSSISSTESKHAEPVAKNTTAHQEFSKHADGGLALLEDRVVVTEADSRRICRRTDIHVLILLAWVYFLQISDKSIIGLSAVFGLKKDAHLVGNQYSNIGNIGYYAQLAMQPLAAYLLVKVQVRQFVPLIVLLWGVSLVGMAVSTNYRALLATRFLLGAFEAAVLPAFAMITSAWYRRSEQPLRVATWTMVGSALVYGIGHIKSSSLFTYQIVFLIYALVTVITAPILYWRMDNSPMEARFLSPEDRQRAVERLRANQTGIASSEFKFSQVIELFTQPSAWIFLACSFCINVGASVSNVFGPLILQQLVGFTAYESMLLNIPFGAIQLLAILLSSWLAYRFKLKSVILAAFMVPVVIGVAILYAVPHIKAHRSALLVGYYLIGFVFAANPLLVTWISANTGGQTKKSAVFTAYNAASSIGNIAGPFIFKSKDGPDYYPGLKGTLAIFCVLIGLIGLQAANLAWLNRQKAAQRVANGQTAQINDTSMANKFEQVDHGLENAFLDMTDKQNPDFVYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MEF2</accession>
    <name>A0A2X0MEF2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C004g03138 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C004g03138</name>
        <name evidence="2" type="ORF">BQ5605_C004G03138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY70318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MEF2"/>
    <dbReference type="STRING" id="796604.A0A2X0MEF2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY70318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="436" mass="47299" checksum="9EBAAAC40D4F1D89" modified="2018-09-12" version="1">MMAGDPKSPPGAPPPPASAPPTVPNGPNQLTSPAAAKPNNAAATSQTFQQTLEQQGQRDMRYKALPGIMAAIQVVPGNRPDRWVQAIFATNDYPTTLATLLNFSAMHATQNIFNPFTHAVEVTLSHQSLSRPSAKDKGDLVACVQSLLLPDTPICFDTGVPFPKGFEAFKPQIIGLQHSTNLRAGVIHHRITVGFALADARDAALATPPVLTWHLAKARLAKAHHFYRNMVELRINVGVSGMPSKEEIVTAFQFVVQHLRNKGYQCQLVQVLRVTAVDNATAYAHTVGDFSAFVHFDDATLFQPPTTILAHLRPEARGTDILPSRMDLCTRGIDVTAICHNYEKEAACVRCHFVGHMEKCPVVQERKRKEVKALVRKGVREGAGVGAEEGRIGEEEEANTTNNINTFSKVVAAGQSLGTDMLELQNRFAGLEVEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MES2</accession>
    <name>A0A2X0MES2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C005g03409 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C005g03409</name>
        <name evidence="1" type="ORF">BQ5605_C005G03409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY75247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MES2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY75247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="56" mass="5956" checksum="E885AD36906C7625" modified="2018-09-12" version="1">MVTANLTEAPLALPTCSIRLTDLIGTKKPTGGHSLTSREVPHCFASESMLWTGASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MES6</accession>
    <name>A0A2X0MES6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P-type Cu(+) transporter</fullName>
            <ecNumber evidence="3">7.2.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cu(2+)-ATPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BQ5605_C005g03260</name>
        <name evidence="16" type="ORF">BQ5605_C005G03260</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.8" evidence="3"/>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY73091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MES6"/>
    <dbReference type="STRING" id="796604.A0A2X0MES6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140581">
        <property type="term" value="F:P-type monovalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd02094">
        <property type="entry name" value="P-type_ATPase_Cu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000001">
        <property type="entry name" value="ATPase copper transporting beta"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000002">
        <property type="entry name" value="Copper-transporting ATPase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF8">
        <property type="entry name" value="P-TYPE CU(+) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00943">
        <property type="entry name" value="CUATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00942">
        <property type="entry name" value="CUATPASEI"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="521"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="877"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="906"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="15">
        <location>
            <begin position="39"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="15">
        <location>
            <begin position="125"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="979"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="999"/>
            <end position="1011"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00080126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SGY73091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1026" mass="109433" checksum="CD38DB6BF1B50891" modified="2018-09-12" version="1">MATCGQEESKLVEDYDHDDKIEVSSVASSSKLPAAATTTTIQLKIQGMLWLACKQWRCSMTCGACVASIENGLRDQPGILSVKVALLAERAIIECDPSVWSPEKLTEEVEDMGFEAQPILPVPHDTVSLQIYGMTCGACVSSIESSVSLTPGILSVTVSLATERATITYDPTIISGARDLVDLVSDVGFDATLVSDENNAVQLRSLARTKEISQWKHSLQRSLCFAVPVFFISMIFPMVSALRPVVNLRLVRGIYLGDIVCFLLTIPVQFGVGRRIYESAWRALRHGSATMDVLVVFGTTAAFIFSTATLLLAPFSSDADYHPKVFFETSTMLITFISLGRYLENLAKGQTSSALSRLMSLSPSQAIIYTDAPTCLKEKRVPTELVQVGDTVKIVPGDKIPADGTVLRGESTVDESMVTGEVIPVHKVVGEALIGGTVNGSGTFDMLVTRAGKDTALAQIVHLVEEAQTSKAPIQAFADKVAGYFVPIVIGLGMLTFIAWMCIAHTSTHLPHVFAEKGATKFMVCLKLCISVVVVACPCALGLSTPTAVMVGTGVGAQHGILIKGAGPLEASHRVDRIILDKTGTLTVGKLAVVGVKWSHPCSAVADLKEASPSMVKFSRQEDIMLLLAAAEAKSEHPLAKAVASWGLRELGHHILPPSIQVSEFESVTGLGVKCNVSGNFPSLSDSQVSHAQHSIEIGNAAFLAGSHIAPDASHAAFRDREEGLGRTCVFVAVDGALACSISLADTIKGEARQAIDALRMMGIHVAVVTGDQRATAVAIAADVGVAPKDVYAGVSPNGKRSIIEKLQKRGHRVAMVGDGINDSPGLAVADVGIALCTGTDIAMEAADIVLMKADLLDVVAAIDLSKRIFRQIRLNFIWATVYNLFGIPLAMGVFLPWGLHLHPMMAGAAMAFSSVSVVASSLTLRWWRRPRSARRPDDPAGDRAEGFISEVLGAAWDSFGSIVISLLAKLRGRGSSRARATDSAMTRRPSEYGLLPNEVDEDEDESEDDIPMVGAARLPRRTEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MFU6</accession>
    <name>A0A2X0MFU6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C008g04940 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C008g04940</name>
        <name evidence="5" type="ORF">BQ5605_C008G04940</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY78758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MFU6"/>
    <dbReference type="STRING" id="796604.A0A2X0MFU6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652:SF50">
        <property type="entry name" value="PEROXIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="1" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY78758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="264" mass="28789" checksum="564A759BA379D912" modified="2018-09-12" version="1">MASRAAAAHCRTGPDHVTSAVHQLVLHPAITSSIKVASTTVGRDKAYRTIQYLARFLAFYTLRKGYTNETVARLTALKSTLGLSRKLMRIGKPFEHLQAAVKSLDVQDPVLKFTALGRQLGYAGYLWNDMLVWAHSSKVRPLSPADAKIVSQRAAKLWFTGISFSLISSIYRLVDLSAREAKARRTRASEKEVERKAELKAVLAQKAAVRTQLVQDGLDILLPAGVLGYHNLDDGVLGLVGVVTSLMGLRSQINKVLGPSVASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MGU0</accession>
    <name>A0A2X0MGU0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C033g11137 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C033g11137</name>
        <name evidence="3" type="ORF">BQ5605_C033G11137</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000066">
        <property type="protein sequence ID" value="SGZ01303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MGU0"/>
    <dbReference type="STRING" id="796604.A0A2X0MGU0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007245">
        <property type="entry name" value="PIG-T"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959:SF11">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04113">
        <property type="entry name" value="Gpi16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015919353" evidence="2">
        <location>
            <begin position="25"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="528"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ01303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="576" mass="64252" checksum="AC9CCD1910EBD6F3" modified="2018-09-12" version="1">MHWASLPHALLVLLLPLLIPGASSSGPPPREIYGESLRLTPLRDGKLHSHFNFTFTAARWRDAGDRLGPNSKTHHHTLLPPELTALAHHYRVTSFDLTLSSGRWDSSWPTRSTAVSGIQLVAWLELLEGESPRDEEQRWDDFKNALGGMFCTGVISGISAGESRPLWGIVLGGSADEREHRLYRATMPRLSATCTESLTPFLSLLPCASYAGLSSLLNPHRLFDSDWTLLGVHVLRDGQANSIQLQVGTVADPIRQDRLKGFLGRRDFSFESLYDRTLQKACPVATESSVQVAIPTDSINPFRIEPSSHGRTIVQVDSKDVVQWDTKQVNETLNIVVDWPDVNVFEHVPTSSPELTPLIVRRLLHGSGQERGRIGIELINNLDSNADVIWIETWPWWLRAFVSTLCATSSTHSDWADLADEVVLSLDYTPPIARSRATTLQALLRLPPRSTTRLMMAYESSYLWYTEYPSDAHRGFEILGASVVLLSPSNSFSTEILKGPSALRVRGEWMRLHTSSTLLSLPTPDFSMPYNVIILTSTIVALFFGSLMNRLVRGWRVVSLDEEDAGYLEQAWVKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MH79</accession>
    <name>A0A2X0MH79_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C009g05693</name>
        <name evidence="6" type="ORF">BQ5605_C009G05693</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY84373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MH79"/>
    <dbReference type="STRING" id="796604.A0A2X0MH79"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_eS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014401">
        <property type="entry name" value="Ribosomal_eS6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002129">
        <property type="entry name" value="Ribosom_S6_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY84373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="265" mass="30554" checksum="5785D29E5368CD4D" modified="2018-09-12" version="1">MKLNFANPATGQQKTIEIDDERKVRIFYEKRMAQEVAIDSLGDEFKGYVVRITGGNDVHCRHTHTASNLEPDELIISFTARFTQKQGFPMKQGVLVPHRVKLLLSKGHSCYRPRKTGERKRKSVRGCIVGADIRALALVVVKQGESDIPGLTDTVLPKRLGPKRATKIRRFFNLEKTDDVRKFVIRREVVPKKEGAKPYTKAPKIQRLVTPERLQRRRHQRSLKRRKTEQQKVQVEEYKQILAKRLAERKESAAVAKKAKNINRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHM1</accession>
    <name>A0A2X0MHM1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C011g06307 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C011g06307</name>
        <name evidence="5" type="ORF">BQ5605_C011G06307</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY11886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHM1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="240"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="387"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="412"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="448"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY11886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1005" mass="110855" checksum="8A18E790DB9DEFE0" modified="2018-09-12" version="1">MSPDSRDTPLHMETPARRVKLDMPLLKAGSKSRDVARWLAGCEDAVESAEWNYGKIATVHLICEAGSRMEGEGGDWYIDSRNKLKALKTWDDFAAEVKARFVSEKTGLAAEHAFFNAQQSGTFNEFIALLTQEHSQAGLASDGTQVIPDELFKRQLLHRCDELLYLRATASPSFALDKFSVNALVAYLQTMWDAITLERATTGMRRLNLRHERGEPTQAVGPRTPRLEGAAKEKAMFEGRCFVCDTVGHISSNCPSKPNTASPRRDPPGSTPGPRTVAAIRAYEDTGDSTAFVGISSDSEDDDERLFALDSEPVRLESNLVPFTTVPGHRRDKLNPKGIPLVFVGYYRHAKAYRLLDPTSMRVSLSRDVKFVETKFPFLSMPKRATAPSIPGYRPITQPMLQPEGPRATPNQLPPPNDELPPPNDELPAPDDEAASVRSDATNAAEVLPPPEQVPEPPAKVKPAWEYDDLARVGPDPGKYGEVDPRNIIEGPRTRRRLVPTMIAKEQLDSGPDGPTNAFKNLILAFAATTEGFAEHDLAMVRDPANWGDVIRTGQEEVWHPPARDEFDSLLNEYEVFEIIESCDLPSGEILLRSGWVFRTKRNQHGDITDHKARLVAHGCSQRPGLDFEKNYAPIVKFTSICALIALAAANGYHVHQADVNKAYLHGKLDKPLYMRVPQGIDLPGKILKLSKSIYGLRQAGTIWNAEIDSTLRSLGYIPTKSDICIYRRDHDGHSHYIALYVDDLLLVGPSVAEIDRVLDALELIYGIKRLGPAEYILGIQVKRGQDGSITLSQERYLCDLLDKFRLGNAKPASIPMQPGVVLDFQDLSAMPQDCTRYLQAIGSLMYAAVGTRPDIAYVVAYLARFSQQPSPAHWTAITQVLQYIKGTLDLGLTYRKNNVTFHGYSDANWGACLTTSRSTMGYAFIYSGAAIAWCSKREHRVAKSTTDAEYLSLSYASGDAIHLSELLAELGHPVPGPVVIYGDNQGSLALAQHPTCHMSDAGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MID4</accession>
    <name>A0A2X0MID4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C108g13197 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C108g13197</name>
        <name evidence="3" type="ORF">BQ5605_C108G13197</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000071">
        <property type="protein sequence ID" value="SGZ10281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MID4"/>
    <dbReference type="STRING" id="796604.A0A2X0MID4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="166"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="745"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ10281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="989" mass="111310" checksum="A2CDC25A96F4B6C5" modified="2018-09-12" version="1">MGDEETAEWTRTTEELRRAVNERARQLRIRAQYPKSLPRNDSLRLPNGELTHDIDVALDHTQAHFQRLYNLEPRDRDHVERLRDDFLAPIRSARTCDDPSSDPLFLRRLSEAHIELLQQPITEDEVVAAIATTHPGRSPGPSGVPYELYHTAPRAWAKALSRAFNAMTERGSLSPRQGQGLVRLLFKHHKIGADRAELSSYRPITLRECDYKLFTKVYVARLNHVLPDLLPPQQHGFVKGRRSADASFHLRLLIEELGARGTEFPDAALLSLDQSSAYDLVEHEWIFAIFDALGAPATFQRVLRMLYSGDSTTARYIINGFLTPPVRLTCGLGQGDPASSSVWDVVFQPFLDALHRRGIALNLSLPTIHPYPQSRAITSLAFADDVVVAVAGSESLTLLDDLALDWRLATNGRLNTDKTVVLPIGCRWEAGDRPLVVKAEGESLEWIGLSFDPTGNTELANVNLVARLEAVLDSARDRGLTHHTRAFYVNRYAIPKILHILSADIPPLEVVKELDRILVDFVRGGKRRSCYGKDVVFTPRFKGGLGVMRMQDVVDSVAARVWDVLLGGSDAIWQGLARAAIVRAHPAPDFDLATDAWPCDYTPIRTDLHPRWQAVLKVPSTHNAQVKPRTLTLANLLALPIKLHTLHYLPGAPAVSRSPYDADYAAFANYAKVADLFRRELYPGGGFHLWTPPTDVVVSNSEYDQRGRPQREHIVAWYRHAINRLRFTPIAQPVAAVRINGPPRVRPRSEVRPTTPLESILPHPIDPPQRLPRPALPDQSTQYNLLSMDRPYTIRRVRRVLNAKAFTDTIGFRDSLQPDDLKGFWKGVNSKALTAREREVWFKLVRNFTPTRSLQFHQKHDDSPACLVCGAPKDDREHYFFDCVDSGNVWIAARSVLCDALGLDTIDNTHYTAVQRMFGLPKLKASLRDQEGAGRTIEIFTGLVLEMISSGRWGMQKWGTRMEGVVRRRIILEERLKLRAGGAWGRRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJS9</accession>
    <name>A0A2X0MJS9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C036g11473 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C036g11473</name>
        <name evidence="9" type="ORF">BQ5605_C036G11473</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000063">
        <property type="protein sequence ID" value="SGY95134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJS9"/>
    <dbReference type="STRING" id="796604.A0A2X0MJS9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000013">
        <property type="entry name" value="Related to multidrug resistance proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF191">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="540"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="81"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY95134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="575" mass="60859" checksum="5F7B32567D58D881" modified="2018-09-12" version="1">MSSATETTPLIGTQAATATSDAYAVAAESAIQSVIHGDVNASAFQVPGTEAQDDVEAAPAAGGPAGVLITEEPLRADLFIVLGGMWVGTFLSALDGTIVATTLSVIGSEFGVSNSIAWLGTSYLMTQTAFQPLYGRFSDIFGRKPATLFASIVFLLGSLFCGLSKTYPQLIAARAFAGIGGGGLTTMSSIVTSDLIPLRKRGVYQGLGNVVYALGAAIGGPVGGLLGDTIGWRWAFLIQVPICVIHFIIVFWKVNIPSGPGDILIKIKRIDFLGSLSLVASVALLLVGLSLGGNEKPWSAPIVWGSIIGGLFVLAIFVVVEKFVAKEPLLAPRILFSRTPGFVSLTNWFATMAQFGIIYQVPLYFSAVQQRSTSRAGMYLIPNAVLASTASLLAGLYMARTGNYRLMLLTAGVLGVLGPLLMSFWTQHTAEWIFWVSMGPAGVAYGAIITITLVALIAAVPPADMAASTGVSYLFRATGSVLGISLSTSIFQNTLKSDLERRIVGKGAHHLIEKIRSDVNYIRTLPHDVRHLAIDAYDHSMHIVFIAITAAAFMALLALLPIRQHALPGSLDRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJV5</accession>
    <name>A0A2X0MJV5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C020g09189 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C020g09189</name>
        <name evidence="2" type="ORF">BQ5605_C020G09189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000082">
        <property type="protein sequence ID" value="SGZ18539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJV5"/>
    <dbReference type="STRING" id="796604.A0A2X0MJV5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="585"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="585"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ18539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1022" mass="114925" checksum="1EBB77B9D9058809" modified="2018-09-12" version="1">MNDDLRAYIFSKGLLLPPDDYLALLLEPFVVELQAPLPSSEAIDEDDIRSIEFWDQRRWEGWVNGVEKEVWEDKLEVKAEVMQSIKGVAREVKRGRWSKIGELSQLMEGEEYDQVFRFPNRLEDDYLLSRVARRRGAFFESEFALKDMIDYQISSPALLEVEDDDELLKMLDMPEIEDGLAYFMVSVVIHSDLRLPTTMEQIAFLKEMTRSIKATGRLTTGQLLTESDDAEGPRPIRLDVDTFRMPSPPLLPRATSRLNESSRLDLFDELDVITPPSSPRGTGVPMNAWNREEGIRSLPSSPVRFSREASFRPIWSSPPTSDQPEKVSEWMEIDKPLFPRAKREGAATLVDLDMPPVPFDSSLLESDDEPNKEVLAPTNPHISELFASDDTIGPAEQSAPDDLTKLRLRVPHLSNPTFAPPPPPPTPTDFASTSSSAWSLKLDRELTSATIGLSWAVDRQVDGLKLDSIMFDDDSEKVGLSDDPQQRGGALFVETMETEDELAELMLEDTSQVEFKTGDTINEFLLQPRAPTIASQSHPTLSEQGHAQSTSSSTSRFTEITASDLDMSKIPPDLIQAVKLTTSSSSPLSRLLSPGLESNNLASESRSSPPPSQEPGDAGLALKSIEDDSGLKDIIMRRLGRLQEASVRPEFTSRRIAIDHFLSTRGRQISLPVAVPKTKAGQREATQTAVMAPLPVSQPPCSPLYQDTPFATPQFLQVDDETLPVGHLRVIGFHSLFQNRLLRSALEDVNIELIHRYSRWVKDRYRTFDPHLILNNHTCVIFRPLWSLVGRAYRAEEVDNTSTSTDLTREEALFTTLYRLSHRFDRILVVLTERWPKTSMTANEYTPPVLKALRELDQGILEHLTGRDDRVHIQVVFSKAPEESGKIVRKLLIDLRHSDLDVGSDSRKWLVDPSEEERLLLQIDTINEYMASRILSQCSANEFFQLDEITREARFAGIIGAERMIEVERSIQELQLRQDPACHRADDAAPTLTGIGGFEACSSMPSDASLTSFQELIFDFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MK58</accession>
    <name>A0A2X0MK58_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C021g09280 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C021g09280</name>
        <name evidence="4" type="ORF">BQ5605_C021G09280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000083">
        <property type="protein sequence ID" value="SGZ20483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MK58"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF405">
        <property type="entry name" value="ARF GUANINE NUCLEOTIDE EXCHANGE FACTOR SYT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="3">
        <location>
            <begin position="781"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="1085"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="634"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="672"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1255"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1411"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1521"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1564"/>
            <end position="1623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="453"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="648"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="706"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="742"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="759"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1420"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1454"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1532"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1580"/>
            <end position="1608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ20483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1623" mass="172312" checksum="8A2693786EB8922C" modified="2018-09-12" version="1">MSTTTDTPPSEERAMENLVLPIVTAPEQDETMPASSSSSLRTSSRRRQLDGGAASTSIISVDSDDARAATTASTTTTPVATSPLAPPPNDRSLPSTSTPASAFSSRPLSSASASRSPTLAVGSSSPLLRVSFDDLHTRTRHLAPSTGQVDRTQIEGLRPRGNPSNEHLVHWSDSHRPPLAPPPQAAGDHGSSTRKSGGGGARALLRKARSFTSSPTLSSSATFDPVAPRDKSPHREPKLSAVPIVPTRKGKEKAVEQQSPPPPPPPTSTSHWLFSPLVSPSVQVDAARPQVSSVPTQTASSVDALSARDTSSSEREANRKKGSTSSRRSTFSIFRRNASQNDTHTLPVQAASTPDSTTFDSPFPSPSTPLTAESYSLPSLPALQLSTNPYRMSWGFGTGSANTSDLRNSPQRAGPPATTLQAGSSALPSPSVPQTASKMTLAKPISSSLRRNGSWAGSTSSSSSGKGALNGDVTMTGGNGGPGVVNHPLTSPATRRVLTRASRSYSDGSQRPISIVVQSDDEPVTPVPVPAAPPQLCRPKTSDSISSDRERSVGVFGAVSNFFSGSASSSSSSNLAATVSSATMSRASSNNSLKSKTTTISPTLANETNEFGALFGAASLPTKGRMRGLSVGAGIFGGSSDGRKRAGSSSSLSNSWIPPTATAVAAPTVGGMLAPTESLSTPTSGRLRASTDPKRLSTGASGGAPDGSSSTSIPSSPNLGMFASPPASPTMMRRRSSFAFYRQSTGTSPSSRKASFAATTPSGPGTMSSTQMARGRSSTMLLASSVPKIDPEEGETPSAFVDRLVSLLTRPDVSRCLAQSADAFHTEALAAYFARFDFTLDALDIALRKLLMEISLPTETQQIDRVMEAFAKRYIQCNDGLFESSDTPYVLAFSLVMLSTDQFNPSNKNKMSKADYVRNTKIEGVGMEVLEYFYDQISVAPFVFVEDLPQNGPGLSRPEAVSSNSIFSSSAGKTRPDPYYLITTGLVRDLRIDISLAIPSRSPFSFTGTTSFFNATTLHQLFARAPVLQTHSHSSTSLSASNGRSRSKSVEALLEGAPLTLMNSTTSYVPPSTPKPKQDVVSNIKVTKVGTLSRKEDLAEGGKKAASRKWKAWSVVLTGSQLLFYKDASFANALGAAILQQPLKGSQRSDTAYTTLGAISAAFRPDAVLSLAHTAAIYDSVRSHTFGCVRRALKRLDRPSPQSYRKYNNVFRLIAPGGRQYLFQAASSENLNAWMHAINYAAAFKSAGVRMRTWEPTASPSMSGKPTPPANGMPEVPMSAEDGVTRMSMNGSSDVIPSSKLPLMNGDRGAFGDEQLMRRASLSSRAVVLKKKLAELEKEICEAKDDLQVDLRLARNLGVLTPFKSSTRERIYLALPAIDKRIRHARINLTKLLCHREILSRDLLVEDRLPSRQASHRRRVSEQTRAERTPKSSREPFDPSITPATPLAPPRPSFTMSGDRTPSTTSRDSFDSAPNDFGVPAPQSWTDDDLDRLRTLSLEGSFAPRMKRSTTETFGSASFHFDAGSRASSRNDASRSTEDDLAARTTTLPSSLFDSHVRSAAIHGQELHPDPDMLRSAQRSSSSLELPTSMSSLAVSGTASPASSAPGSLEDLTLEAEIKSPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKS9</accession>
    <name>A0A2X0MKS9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C032g11069 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C032g11069</name>
        <name evidence="2" type="ORF">BQ5605_C032G11069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000067">
        <property type="protein sequence ID" value="SGZ04519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="840"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="861"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="884"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1055"/>
            <end position="1066"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ04519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1519" mass="168523" checksum="869B542ED4FBEEDF" modified="2018-09-12" version="1">MVNSEVSLKPLLATNVPMIFTLLVSINFTETGHCFVYLRDILEEVAELTGLALQEDSCFDYWVVDDAATSSTHSTLCLASCLYDQLAAFTAATDSSDKVLGLTGFGLDIDSLPAEATITLRVYEHIKARLPFVNITTRPQRRVDAPVSSGAPSASKHDLLVREKREASPSHRISGNLRPNIEPDSTDDKLVNSEDHANLPTYSEGRTTMTDLMLEAYPQEIVLDPWRPNGTWGDVLIVRMDPGSSGGLSHMWAFSASSSRTDSKGRWKGPRLDANVEYSKYSKRRCMGVFVCCDQSCPGKRRPHTSLSTASRSKLFQEETPQLVTGRPKKAATRKHLAPNVERPSDELPPCPITSCNGPMRHILCSATIARGQREECPGEIYIWHSGYHLHPPPPVSRPSPQHLEELQQLRTAAPQASAAELRMGQMTAFPQDPRHRPSASEICPVFDSTRSISRYAPRVGHSKRNGALPDTLMSAIEAVANAGCLTYIKIPRQRQGQPLAEQIHDPDPRKQPRNDGSRSKSKITSNSLTDSETSFGIQTPQMKARLSETIEDRLVEGNSGWPTDAHNTYFRDNWVLLATVCYSPSARRGFPILYSDIVNGVTFVVDYSSAQISGLRQAISDWYVARKTADVGRLNVTPNQVSQWTAEAIQIGEKAASGCAFHFIEQVRRFGVRHLSTQTERERFAMLVNTMRNAKSHASIESMAKRTIDEFPVSENWIKWWTRPAIRNVVFKELNGSAERCVATTTNAVESSHWLLIHSCGGERFGPTELKVMRPVRAWHSVTTNPLSSSKTILAFALKTDGYVRSSTYHEQGNVRAHIKEIKSRNRVPSSYVTRLAGIGFSESPQGPSDLSKGPATPPLSESTKLPPSTSNRSRQQPKNRSRQGNGPTAQSMASKKGSRRVDYPRKRKIPDPPSGEHSSSESSDDLHQTSNSKSKGSPPRSDFSGPSRRVPVVPMAVRALNEETELSQILLAQHNARNLEAPSGRKYRIPRKRLAFFLSEPESQSEAKRTCTSVFDIPLSMVASKSELAPSKSARKVENATPKPASTSTSLERTSDKLPEDSRSAPRVKFAPPKTPTSTSLGSTIVQLHADFWLRSGEDGPVVIIQGPWSDNSCWIDSTLIALLSVANGLEPWLQCLDILNTHTAYVIPPLGDEMVLRLRPRYLAFELWDAIREYTALARKFDTKPAANAIEAYTQLRERIFPLWLGCRKSAEAILQLHLSGGTWLETLHSFTVDHPVLPSAVTLNDPDRTLVELHLQRAGYCTACNCIQIEVSPRRQFVVDWPLLISSLHLPSHSLETLSDVLASIVGQPLKLYTEAKNSGRRHHKRNCPGGSYVQFVSITSLPRVIVININNVYPEHSLAPAELRFGVSDQMPEMVWRLRSGVYNINNSHFVTNATVGYGQEAACYHFDAIKGSLARPIGDRNAGGLVSVLFYELEEESLNFLQAFNLLLTRQWHEMWSLYHEPSDPTNIGIKVSSLPPKGTLEEGQGVWKMEDASAFFHECEIVSVGNAKKADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLP0</accession>
    <name>A0A2X0MLP0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C002g01775 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C002g01775</name>
        <name evidence="5" type="ORF">BQ5605_C002G01775</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY35526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MLP0"/>
    <dbReference type="STRING" id="796604.A0A2X0MLP0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF142">
        <property type="entry name" value="RAN-BINDING PROTEIN 3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="4">
        <location>
            <begin position="562"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="319"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="532"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="326"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="339"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="445"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="460"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="473"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY35526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="695" mass="72145" checksum="BFF019EE685E3C50" modified="2018-09-12" version="1">MADLPSDPTPTPAAPTEGDELSSGTGRSAGAGPVPSASSGSKAGRQKRHRDDMTPTTPRSEDETKVLGGLTPLAKKGRVQPDAKSKLVAGTGADDGQQGVASTSSSLASSSTADVEAEQADIDDNDEEEEDEDDEDEEGDKHITPPRSAPTGLEPNSPPPTPMQSTQRRAEGQETKAIRKRVANLEWKDGEQGVSTVTTTNESDVEIADVAAEVLESAKMAEGEEAQVADEVHETAKGVHQEDSEAEDKLMKEREASVAADVAESAQMLAQEDEAKQDKDEHIADVASEVAASAKKVAQEDKKDQEVAQVAAEVAESAKVLAPEIPTEPTPPANPPATAPTAPATTSFSAFSSSSSPFASVSGASPLSGMAQPKASTGFAEYIPPTTEAKPKSRTSFGGEAAPLVTSPPLPASHPETVDSAPLSLVGRSSPSAEPVPVPAKIIPTFTSSTASSTFTATTPLGNSAFSTGPSPFAKFASTSGFAAASSSSKDPLASTSTNSGALGSTSTTASGGFGSFSGASPFASISSKSKTSALSAQGSHEETNGDESTGSSSTRSRKMGEPEEIDESKRVFTEQEVVTGEEEDELVHSVRSKLFVMHEGAWAERGVGLLRLNRTQGKEDKTGARLVMRADATHRLLLNATLFPSFSIEVNQEKYVRFAVIEAGEPTSYMLRLSGPTTANALVKAVSEEVNRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLY3</accession>
    <name>A0A2X0MLY3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cyclic pyranopterin monophosphate synthase</fullName>
            <ecNumber evidence="3">4.6.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C012g06929</name>
        <name evidence="14" type="ORF">BQ5605_C012G06929</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:49580"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.6.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.17" evidence="3"/>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MLY3"/>
    <dbReference type="STRING" id="796604.A0A2X0MLY3"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061799">
        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061798">
        <property type="term" value="F:GTP 3',8'-cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01420">
        <property type="entry name" value="MoaC_PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21117">
        <property type="entry name" value="Twitch_MoaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.640">
        <property type="entry name" value="Molybdopterin cofactor biosynthesis C (MoaC) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013483">
        <property type="entry name" value="MoaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040064">
        <property type="entry name" value="MoaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010505">
        <property type="entry name" value="MoaA_twitch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023045">
        <property type="entry name" value="MoaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047594">
        <property type="entry name" value="MoaC_bact/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036522">
        <property type="entry name" value="MoaC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050105">
        <property type="entry name" value="MoCo_biosynth_MoaA/MoaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002820">
        <property type="entry name" value="Mopterin_CF_biosynth-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02666">
        <property type="entry name" value="moaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00581">
        <property type="entry name" value="moaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006870">
        <property type="entry name" value="PRK09364.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22960:SF0">
        <property type="entry name" value="MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22960">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SYNTHESIS PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01967">
        <property type="entry name" value="MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06463">
        <property type="entry name" value="Mob_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01383">
        <property type="entry name" value="cyclic_pyranopterin_phosphate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01386">
        <property type="entry name" value="main_SPASM_domain-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01067">
        <property type="entry name" value="SPASM/twitch_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55040">
        <property type="entry name" value="Molybdenum cofactor biosynthesis protein C, MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="13">
        <location>
            <begin position="93"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGY16622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="675" mass="74542" checksum="D4614E20D13AD4EE" modified="2018-09-12" version="1">MPSRPLMCIATAKPLSAWYERTSLLRGAAVRHHSSTSSSTLTSLTGTFSLGSEPSSATSDHTALLSTRAKAQARIARVDSTSPSKVSPFLIDSFGRKHDYLRISLTEKCNLRCELDCTTPCMAQTPTIRTYCMPETGVKLLPRDDLLTTDEIERTAKIFVTNGVTKIRLTGGEPTVRKDLIDVVTRLGRLPLDSLGMTSNGISLKRRLPQLVEAGLTHLNLSLDTLDPFKYELMTRRRGFSAVMESLQVARGLASQGLKTKINVVVIRGLNDDEVPHFVELIKDMDITVRFIEYMPFEDNRWSTTKLVPSAQLVAKLQTIHPTLEKLIDPHSDTTRSWRVPGYRGKVGFISSMSDHFCGECSRLRIGADGRVKVCLFGPPVLSLRPLLRSPETTDQDLMESVGRAVWGKKFAHNGLGGAEGIRENGKMGPMVGIVPDALWAEWIAFNPNWLRPQRPRQPLFARVPLHLLARSTPYAPRLATRLFSYSVRSNHAEDDSKPVDTLTHIDSRTGKASMVSVSSKAITFRSATAVGRIRLNEQAWSLIDFSTTSTDQVDRSSPPTMRTKKGDVLTIAHLAGLMATKQTSTLIPLCHPLLLTSIKLTLEPLFESTSIQITCRVECEGKTGVEMEALMGCQVALLTVWDMCKAVAGRDMVIEGVMVVEKSGGRSGDWKRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MMM6</accession>
    <name>A0A2X0MMM6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C015g07824 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C015g07824</name>
        <name evidence="2" type="ORF">BQ5605_C015G07824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MMM6"/>
    <dbReference type="STRING" id="796604.A0A2X0MMM6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="1">
        <location>
            <begin position="400"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY17574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="587" mass="65788" checksum="650DC94298FF2535" modified="2018-09-12" version="1">MYQHTVVSAAPACGVHVPIRSHVPALCRLFYFSCRSNEATAFPNKPSLLCPKVARDSGRAIATSPSLGREDSAVPWASSSARCWAPRGSTLLFVPLRSTESAPRRVMTTIQPILALRHVYEPAVQLRVRRARIALKPLKPHVSIRDDLGPQTAVCTHCKARHWELGPPVFRVFGRLYHRLGALIPAVTQRPTFAQTWLIDPAEATDTRLGPDGADSRMQRSTLTKLESILRTGNRFVREFASAKARAGWDTAREWVLRLCLPPGRDRRTHNLPTSSTEMAMLICDSDTNTGDRGPQDLILQVHGDRCPDGEDGSHPNIPFCGFHQAGPPIARNREQIDNGVQLRELLAGLGPQMKKTNRRTKTATMRMKTARKGTKRMVMVNVSVFRSFSYVPFFSRSQYLAYYLHERGDYFSIPHATQRLFLEFVIDGYSQVETDRLNYIRFHQETLRLTTAQGITDAVDNGLTRIRLDVTQRYRDAMACVVKYGKPSLFITVTCNPDWPEIKAALGPNDQASNRPDLIARVFEAKLNRLCDDVFGNKQSAGCFGVVLTHTHDIECQKRGLPHAHILITLAPDDHPLSTEAIDKMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MMN0</accession>
    <name>A0A2X0MMN0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C026g10127 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C026g10127</name>
        <name evidence="2" type="ORF">BQ5605_C026G10127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ27570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MMN0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="527"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ27570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="592" mass="66018" checksum="8D0D50A05D1D75D9" modified="2018-09-12" version="1">MVEEFGEGDDDDSPDRLYEMIDRQLEGRRKIRTRQDLDDYYRRFKRHSEPLVKKEVLSWQSESSLFLEGLPRELVKEYESLRKLARSLLPSVEQMARDREAATGWRVTSAEMVEIRKKQKEDDLKYPRELRIGELYGEMLKLLRGGGRTSRRGRDTRRRDFYDSDSDSEEEAEDRRDRWRNDRSPSPAPRSVRFSGLPLSFIRRQESESMPSTATRSALSSRSRSGAGPEDNGSRSSSLPDDFINDFRRLVVNTTTMSQELATMKQEFARFQQPGSLYGGNVQGPQQGQSGNQGQAQRGSQGFGYGGGPDANMRGGQPRPNGYATGANATPYTPRNPGLDCRGCGLGGHPTRACPKVLERKSKGDVTEGESGRYYFRGRECPLPHRLPEGMPTYEALWDAWEKGLEQRNGANRGGNGLMGQDGQGTGSAMRTNVGFFSSADERDEDEAPFDVYAASRQVRARTPNGPYEEAAKKRAAEKAEKDKTVRGEPCPVSTPPRVSFDPLAKEVGKVKVEASEAPLRDEEMTEASAATNATSTTRRRAAQSMLRTPVSQRFSVPSALEHVLNGTKVELVEIEQRCAERVGGSGKPMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNM3</accession>
    <name>A0A2X0MNM3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C055g12648 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C055g12648</name>
        <name evidence="1" type="ORF">BQ5605_C055G12648</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000092">
        <property type="protein sequence ID" value="SGZ29215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MNM3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ29215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="119" mass="12802" checksum="F359DDC67F731A7F" modified="2018-09-12" version="1">MWAKSCCSLSAPVTVIDTTGLDFIRLDFGKASSRSDMPDRPTASRERPARPGRVVLWLIRLGVGVTGVRADELGRCVGSDWVVAGVGGASEDETRRIDSDCAWAGGAALDWRWSDSVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNV6</accession>
    <name>A0A2X0MNV6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C023g09662 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C023g09662</name>
        <name evidence="1" type="ORF">BQ5605_C023G09662</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ23925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MNV6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ23925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="74" mass="8946" checksum="DC1267B587A10389" modified="2018-09-12" version="1">MTRTTMTIDPDLPLFSPTANRPQVYRWQSAPQATRRQGRPQVGARRRWCEEASPRELTFYLVWSTHRRSQHYQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPZ6</accession>
    <name>A0A2X0MPZ6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
            <ecNumber evidence="9">4.2.1.93</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP-dependent NAD(P)HX dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C047g12327</name>
        <name evidence="12" type="ORF">BQ5605_C047G12327</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(6S)-NADHX + ATP = ADP + phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19017"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>(6S)-NADPHX + ATP = ADP + phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32231"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.93" evidence="9"/>
    <dbReference type="EMBL" id="FQNC01000113">
        <property type="protein sequence ID" value="SGZ31179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MPZ6"/>
    <dbReference type="STRING" id="796604.A0A2X0MPZ6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047453">
        <property type="term" value="F:ATP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110051">
        <property type="term" value="P:metabolite repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000023">
        <property type="entry name" value="ATP-dependent (S)-NAD(P)H-hydrate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017953">
        <property type="entry name" value="Carbohydrate_kinase_pred_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00196">
        <property type="entry name" value="yjeF_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592:SF0">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01050">
        <property type="entry name" value="YJEF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF C-terminal" evidence="11">
        <location>
            <begin position="7"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="179"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="164"/>
            <end position="170"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="230"/>
            <end position="234"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGZ31179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="363" mass="39266" checksum="C315B1AB7198E5C1" modified="2018-09-12" version="1">MPSHRQILARCQRLVPPLSPTLHKGQAGRIAVVGGSQDYSGAPFFSSMTTLRLGADLAHVICEPSAGNIVKTYSPDLIVHTDLVQDSTEASLTKLFESLLPRLHVLVIGPGLGRSNHMQLAARTAISLARKKGLFIIIDADGLWLVQSDPKLIQGYPKAVLTPNVVEFKRLCKAVVSPPGERTSVRPTPTKLAYITPTPKNLDTDSSTSDPSLLAGKLAKALGGVTVLEKGTVDRIVNNDKEEQAWINETKGSLRRCGGQGDVLSGAVGCFLAWGLSYLQKQQGEGGVGEKKSDPITEFEIPRLAAYAASTITRTASRLTFEKKKRAMQTSDMLNFVGEAFEEVFPDMVVEEEQQEEGGKDMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQ07</accession>
    <name>A0A2X0MQ07_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C001g00202 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C001g00202</name>
        <name evidence="1" type="ORF">BQ5605_C001G00202</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY44797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQ07"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY44797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="87" mass="10322" checksum="5694AB70F3DAC027" modified="2018-09-12" version="1">MEMVDQLVSCVVKEVYYRKFRKAYPDLRHDVLVCGAWCESFQRQLCDVVRFKNESTARLSLEAGSAARYLMRYLCLLPPSYEEFSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQ57</accession>
    <name>A0A2X0MQ57_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="5">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C044g12167</name>
        <name evidence="8" type="ORF">BQ5605_C044G12167</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="5"/>
    <dbReference type="EMBL" id="FQNC01000114">
        <property type="protein sequence ID" value="SGZ31404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQ57"/>
    <dbReference type="STRING" id="796604.A0A2X0MQ57"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF937">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="7">
        <location>
            <begin position="5"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="6">
        <location>
            <begin position="149"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGZ31404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="491" mass="54208" checksum="7057A0F2C011F0FD" modified="2018-09-12" version="1">MVNSAGCDHLLSALKRGTQSLDKYVLAIRWGSQLLDARAITSKATSIHPSCCSVCSATPPRPCLCLDCGMLLCGPNAHRGSHLIQHAEQSDHAQFWDVRSRAIYCVRCDDYIFHPSIERLVASEAAAVGKLINRTEVTGHGVKGALSPRGMRNLGQTCYLSVVLQAFIHNPLLRAHYLSDRHNRKLCGQSAKHSVCLACEMDRLFSDYCTTSESPCGPTQFLHAIWQSSSDLSGYAQQDAHECLISALNQLHMSSPESSPSTDCNCVVHSTFAGQLRSQVTCGRCRTTTSSTELFLDLSLDLQMSGVTTSLNDCLERFTRSEQLAENAYKCARCGDSVHAASKQLSIDRMPPVLCIQLKVGERGNYLNEVASVKLLTSSATCTFQRFEHTHSSQKLDKPVRYPLVLDMQAFMSQRQDTALHPEIGASGPTILYQLNSVVSHEGSLSTGHYTVLCRGDDDFWNFDDERIRRAPLSEVLNVPNAYLLFYVQGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQA4</accession>
    <name>A0A2X0MQA4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C045g12219 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C045g12219</name>
        <name evidence="2" type="ORF">BQ5605_C045G12219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000115">
        <property type="protein sequence ID" value="SGZ31633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQA4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="7"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ31633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="63" mass="6803" checksum="9DA2C8B7C3080F7B" modified="2018-09-12" version="1">MALVWAWGRIPSRHGPAKKPAGQRKQGEGRQTGEAGGKAKIYGVSSEQQAMLRARIVGSSKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MRB8</accession>
    <name>A0A2X0MRB8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="23">BQ5605_C026g10145 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">BQ5605_C026g10145</name>
        <name evidence="23" type="ORF">BQ5605_C026G10145</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ27622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MRB8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0229">DNA integration</keyword>
    <keyword evidence="18" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="16" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="15" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="16" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="17" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="22">
        <location>
            <begin position="415"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="160"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="700"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="21">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="SGZ27622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="841" mass="94164" checksum="71B5FE586DE6F571" modified="2018-09-12" version="1">MVKSKSLSAKNIWEKLKQHHEGNADPFKIRTLLYDISNASYDEDTNLGEFLQGITDKVDQLEDLGQKFKDEAIVAFMLQALPPSYEMLKQAIKLSDKCSVDYAVNRLTDEYSERKLTGKYDKLLKNAGALAVREGTQVKRDPNCICRGCKGTGHYQIDPECPKYDPNVKRGRNKNHSNKKKKQHKHSKGSADSEESASFALVVKSLEESHSLHINVANRVSQNDQSEIWILDTGASQHYVGNASLLTDRQHGSLNVQTASGQVVHCDTYGTVRFKLRSGASLSLSNVYHLPGAPVNLVSTRALYRSGASCGWEDGRDVMTIKIKGLTIAKTLNGTGYTLDFTRIVEDQAHVATRATVGAPLMEWHRRYGHIAVSWLKELVKSGAVDGLVLTDEKVHDCEPCISSKSRVSKFSESVTHVTDVLQRVFMDIGFVAEDQVDFQGRKAYLAIVDQYSTAKWTFPLKTKSAEEVTRVWIAFRQGVEKMTGRKIKRVRTDNGNEFTNKLIGTDFQSQGILHETSAPYTPQQNGTVERFNGSLMAIVRAVLAASKLSWKYWSYAMEYATFVANRVLHSKLDGKTAYEVFYGKKPKVSHFRPFGSTVFAQVPKSKRSKLEPTSVRGTFIGYDNEYNYRVLVDSDSEHKVVITRDIAVLNLQPEEVRAPEVTTLLEGPDEDVGPVLEGNDAGDELQDEVAVEQIAPARPNRPRWEYGDPAVRGRNPGRFEEIDAGNEIHQRTRGQRRIAEQQGLFVTDIPELDPERPIMSGYAMISTDRPAVPSSYEEAMNNVEADKWKEAIQDELNAMDRHQVFADSDLPHGARALGSKWVFVVVGASLVTWRLIDDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MTA0</accession>
    <name>A0A2X0MTA0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C002g01347 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C002g01347</name>
        <name evidence="3" type="ORF">BQ5605_C002G01347</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY32307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MTA0"/>
    <dbReference type="STRING" id="796604.A0A2X0MTA0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="125"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY32307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="190" mass="21397" checksum="ACA7E5CDACC206A2" modified="2018-09-12" version="1">MVRLLLFLYQLAARWPKGLKTKEEPIDHRREEAVEAVNSYEDDDPAERDPPLPPDDGHEYRPYHVGRTPGLLKTINEGNTLPLITLVSTRHPPLPKTFRNAMASPEAESWYAASVKKLNSMGLHKVFKLSSPPTGARALGYRWVFARKEDAEGNIINYKTQLVVEGFAPRLGIDYNKTLALVSNPEGHEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MTC5</accession>
    <name>A0A2X0MTC5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C047g12312 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C047g12312</name>
        <name evidence="6" type="ORF">BQ5605_C047G12312</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CENP-X/MHF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000113">
        <property type="protein sequence ID" value="SGZ31131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MTC5"/>
    <dbReference type="STRING" id="796604.A0A2X0MTC5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22921">
        <property type="entry name" value="HFD_CENP-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018552">
        <property type="entry name" value="CENP-X"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09415">
        <property type="entry name" value="CENP-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGZ31131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="105" mass="11651" checksum="254D6CB2F655D724" modified="2018-09-12" version="1">MAIDSEHSPQFKERFSSSNSPTRPKVNHSPIQSISLSLTRHRAVNDASIALSSQYLRLLTTEAIHRAAEVAEKERALLSPEERRGPALLEVSHLEKVLSGLLLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MUC5</accession>
    <name>A0A2X0MUC5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C041g11947 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C041g11947</name>
        <name evidence="5" type="ORF">BQ5605_C041G11947</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000119">
        <property type="protein sequence ID" value="SGZ33236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MUC5"/>
    <dbReference type="STRING" id="796604.A0A2X0MUC5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015916086" evidence="2">
        <location>
            <begin position="20"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Retroviral polymerase SH3-like" evidence="4">
        <location>
            <begin position="120"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="3">
        <location>
            <begin position="342"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGZ33236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="451" mass="50165" checksum="32CBC2185847464E" modified="2018-09-12" version="1">MFVLVTIIVLYHTFATALAHATGRYRTMTQLDTSHLDPTVSVTVRPSMNIVALLGHLNSNRALHLPNDTLVLDSGASHHMVKDASLRRLAHPFTRCRRWRWRITHGARHRLDHHTNIETCDASVFTPTSARPSKLEPKAKPFIFVGFNNKSKAWTLYDPTTTSFFLSRDIKFDEQVFPARDAPIGPPQPRMPPTTGEWTFVDAAHASRAPPRLSTPPVVHQNRFAVLETDESDDAMIDMSNNGFDTPSDMSRTQFSPSPPASDVTDDSADPIDFLSCPTRATAFAASAASPSVIELEGPTEDPQNWSQAVKSGKEDIWRQAAADDFHSLATEYNCFTPVDSSLPHGAKVLGSRFIFRTKRDQLGKITSHKGRLVAQGFSRRPGIDYDETFAPVAKFTSIRALIARAAAKQLHVHQADVDKAYLHGKLKEDLHMRVPQGVVMPSWPSLERAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MVQ5</accession>
    <name>A0A2X0MVQ5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C003g02259 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C003g02259</name>
        <name evidence="7" type="ORF">BQ5605_C003G02259</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MVQ5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050295">
        <property type="term" value="F:steryl-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904462">
        <property type="term" value="P:ergosteryl 3-beta-D-glucoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041036">
        <property type="entry name" value="GH5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052066">
        <property type="entry name" value="Glycosphingolipid_Hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308:SF5">
        <property type="entry name" value="ERGOSTERYL-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18564">
        <property type="entry name" value="Glyco_hydro_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="5">
        <location>
            <begin position="909"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5 C-terminal" evidence="6">
        <location>
            <begin position="1451"/>
            <end position="1563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="376"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="764"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1486"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="376"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY39659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1608" mass="179575" checksum="A93A77E777E2D31D" modified="2018-09-12" version="1">MHQPSSDRRAGQRLSRHFSADPRSLDAPGVEAQSIHGSFLDEPMAHGLSSESHVGWTAPDDDSANAAHHLQLAEDHAPMLYDYSQPRPDHGDLRQARSSSNLRSSYRLSSHYPLESSNPRQRGDRGDRYQVQHESPGKVDGTSTSSHPSDARPEISASSTFNHLRPRTCVSNKEPSSGSSRENSPSTIGRDEFSSGQTSVAAASPSARINAMAEPVGDQVKNKIKQSVDLLAMSLDLLSFLKEHRPALPVIKLPIPIASSSEAQGVVGETLSGHIGRASSNATSRGAGATKVDGWQISRSQRARTDPWACSGCHRDLGWLLLRGPASAEATSYRAVFLCNDCSPIAKEPNSFHSDHVENMSEPSYYNSFTRFVEEESGHPLPEPRPHAGSDRVRPRKKRKEVEDSSAACDVCTRIIASGSISAIDRDEAPPNLLVEFICASCHDRYRRCTDCGSRFTPRVGTGKWRLKELFADGVKSCSIPHRPLVLEDTTCDTWRVSDLPHGSDEFSAFLHETHKALVGAVMVVIAIPDTMESDAPFCVDFRTAAMVCNDLHSILSSLVTQDIEEELGIRRYLALRWHNPSKQERSNIFVLQPQDPNVVAQERPERLMREGYSLHSYVFAELDLKHGSVGIHAMVPRGIGHSYYAQSLLAQALLVRMRADLLETNKARVAQGLKPFPKIHEVWNFMTIGKSSRVLQRDESQRGMIELDQYLEQYKDVTDPSHFPPIRPFFLPTAYLSRYRFWARRFEEDDDLTAIQRSRYVKAATKRRQQQSVPTGLPRVVGPIERLPPPTLTDADADFGLVNSLSMSDPPPAYSAAVEASHASCSAEYVIGSSSSTAASWTDSELRMVSSSRHFHDQFDRRLLLHGCNLSGINKLPSKPDGATHVLNEGWWDHENVSFVGRPFPLDEAHDHLARLSQWGLTFVRFVVTWEALEHSGPGQYDTDYIDYLRSLISLFPEYGIKCYIDAHQDVWSRHTGGSGAPTWTLELVGFDIRNLKATGAAHAHNLNLDDDDPAPQNWPSGYTKLAGATMATLFWAGETFAPKRQVKRGQSAAVWGQDAPDEKVGVQVFMQKCMIGAFGALADALTNLPAVIGFEVMNEPHPGYIGLHSPYSFNLKKDLAIGHFPTAVQSWALGAGHSVLIDHYGPSFPVTAVTHQTLISPPKGITAWKEGVECVWKEQGVWAWDEKKKEALALRIEYFNQHPETGVQTDWAKDFYFPFCRDFGERIKEANPRWYTMAEPLPNEPCPRWTPESQPHNLIYAPHWYDLQALFTKSLGFMTANVQGLARGMFLLRALYFGRNGTRKNYTAQIREVIQSGYRTLGELPIILGETGVPFDLNGKQAFASGDFSWQERQMDAICSALERNLISFNLWNYNPLNTDQWGDSWNAENFSWFSQSDMTRVKFDAAKSEDERLNVGARVLDAIEVSLSGLLWHARGGNGLTHDRPLQRPYASKVAGIPYAFSYDFKLLQCTFSYVNPTNPKDFRTRRPQNLATTDDPPIPGTMPRSRETEIYLPRRRFGGLNSRLKVRLSDGEWKYDEELQTLYVLHANLTPGFIHTVRISVDGEVLDALLIIAGMIVLGITMTCALSQYDQAWLVEKVLAKSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MX74</accession>
    <name>A0A2X0MX74_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C005g03234 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C005g03234</name>
        <name evidence="2" type="ORF">BQ5605_C005G03234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY72931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MX74"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY72931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="377" mass="41768" checksum="B97E3605C9E8E300" modified="2018-09-12" version="1">MGLLELTRAPAAGPAARLSSLSRSDQQNQLPAHNDNNSTDLGIATQQVHRPRTPLKPLKPHVPIRDDLGPQTAVCTHCKARHWECERSKSTRHFSACCSQGKVRLPPPPQPNPEYRQLLEGSDSDGCIPRECPVSRTPHVSDTSTALPSTRRTLGALNPAVNQRPTFAKTWLICPAETTDTQLGPDGADSRIQRSTLTKLESTLRTGNRLVRELASAKARAAPKWRCLSAIPTPTREIVDRKTLFSRCTVIDVPMVGPSTKLLARSIQEDSFHLNIPLCSSKQAGSSFADKEDEDEEEGDEGNGDGEFSRSQLFAYYLHKRDEYFSIPHCTQRAFLAFVMTDTPRSRPIDSTYLQLDQEKPPPHHGPRHHQLDPGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MY44</accession>
    <name>A0A2X0MY44_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C001g00574 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C001g00574</name>
        <name evidence="1" type="ORF">BQ5605_C001G00574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY47787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MY44"/>
    <dbReference type="STRING" id="796604.A0A2X0MY44"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY47787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="361" mass="39811" checksum="5026977CC2FAC73E" modified="2018-09-12" version="1">MFGTAWAGLAKTFNNYRPDWSSAGSDSANLLQRTPTAPTLAESASFSMEFEQGADAASSYWKLIFTFRRCVLGRESLEVKSVDLENGQSKMIQDAISVIGAKHEIAVNLKHVEARTARMGRASDSAEATLARDRINAVLRSFQGKHKVFLGVEAGEPTDIISGFGMQSFGQARIRSIFLAAKSNYLKTLFDSELAEKVLKTVGDDQLCQQARHLVEVTEYSSSVYQAVFTWLRTGLVKFAPLGDTQKGAEPDPQVIGEIECNVTALSLYRLGHHLQLLELVELTLAWMDDNLSPDNVIFELSRDWTGVPTEVKEKILAFAVANWDDVRRSKHTTSVLKTIIGQGPPSVALIELMLLALKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MYG6</accession>
    <name>A0A2X0MYG6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C005g03694 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C005g03694</name>
        <name evidence="2" type="ORF">BQ5605_C005G03694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MYG6"/>
    <dbReference type="STRING" id="796604.A0A2X0MYG6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY77679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="321" mass="35867" checksum="6191472F4CE366BB" modified="2018-09-12" version="1">MQSSAPLASAPKPANGTERPTPTNPLWSSSTVGSLPLSTSCRAFGKRDPLAPSLFVLAIEGFACQIRLRVKGINIAGLQNIRELLFADDACCALHNLSDLDHLNRAIELYERASASKLRNNKSFLYPLGAFRDRPIAPDLGTWRLSDSQFRYLGIQVGVEIAEDAGWEDVKASTIARIRSIPMYDLPYAAKCSIINIYCYTKILYYSRFLPAPKSVVKEIEEAAMLAIHGRASDGTQRRPKVSRSRLCTPLDHGGFGLIDLPRRLAIDHAKWAYFCHPPPKWDHAVRKTTKLLPARWVQYFEAWALVTTLNPPELSKSQNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MYP5</accession>
    <name>A0A2X0MYP5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C008g04945 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C008g04945</name>
        <name evidence="2" type="ORF">BQ5605_C008G04945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY78769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MYP5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY78769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="210" mass="21330" checksum="0E798A6A009B1302" modified="2018-09-12" version="1">MIQGSRTTWSSNESISNKVGNATGGTVGDETILHQATNLASHSVEYAKSVVGLGGHKAAESVEDATENKQGGVTLGGLVNESRDLAANVLHTVQGVVAGGAQQAKETAHEGADQAQPQGKGVVQQVREVAASAIGAAENYASHSIIATGAKKVEEGAGELSNSSTQDLKNKASNAYDSAAKSTSNTANDLSKKADSAASNVSKKVDEKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MZQ9</accession>
    <name>A0A2X0MZQ9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C008g05305 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C008g05305</name>
        <name evidence="6" type="ORF">BQ5605_C008G05305</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY80111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MZQ9"/>
    <dbReference type="STRING" id="796604.A0A2X0MZQ9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056552">
        <property type="entry name" value="Ribonucl_Kappa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026770">
        <property type="entry name" value="RNase_K"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31733">
        <property type="entry name" value="RIBONUCLEASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23489">
        <property type="entry name" value="V-ATPase_su_f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY80111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="88" mass="9040" checksum="8B575CA69AE82171" modified="2018-09-12" version="1">MAIRPLVGTPLAGCCTVLSVLGIVILLALGLAFDHGADVLTGSTKSPKDAHAVAQQCYRAAIVYAAFVGFCGCQIGMNARHARGAVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N333</accession>
    <name>A0A2X0N333_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BQ5605_C033g11199 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C033g11199</name>
        <name evidence="11" type="ORF">BQ5605_C033G11199</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000066">
        <property type="protein sequence ID" value="SGZ02266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N333"/>
    <dbReference type="STRING" id="796604.A0A2X0N333"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18024">
        <property type="entry name" value="DEXHc_Mtr4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13154">
        <property type="entry name" value="KOW_Mtr4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000141">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.300:FF:000001">
        <property type="entry name" value="Mtr4 exosome RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000002">
        <property type="entry name" value="superkiller viralicidic activity 2-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF7">
        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="137"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="394"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="375"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGZ02266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1083" mass="120064" checksum="36289013D172A95A" modified="2018-09-12" version="1">MAPPSKSKREHSPAPAASSGTAQPLVSPPSSKKARIAGATSASASTSKPPVMGNVVATDEFETEAKTTVPVAGSGAAQADGEGDDKPSQGLILTHAVRHQVALPPSYPYVSIASHVPPAEPARTYPFELDPFQKVSIASIQRNESVLVSAHTSAGKTVVAEYAIAQCLKAGQRVVYTSPIKALSNQKYREMLAEFGDVGLMTGDVTINPTASCLVMTTEVSSYSVKSYIHRIDSDTPLLQILRSMLYRGSEIMREVAWVIFDEIHYMRDKERGVVWEETIILLPHKVHYVFLSATIPNAMEFAEWICATHQQPCHVVYTDFRPTPLQHYLFPAGGDGIHLVVDEKGAFREDNFQKAMGALAEKAGEDPASSTGGKGRKGQTKKGGPKGPTDIFKIVKMIMVKNYNPVIVFAFSKRECEALALQMTKLEFNTEDERGMVTSVFQNAIANLSDDDRQLPQIEHILPLLKRGIGIHHGGLLPILKEVIEILFQEGLIKVLFATETFSIGLNMPAKTVVFTSVRKYDGRDFRNLSGGEYIQMSGRAGRRGLDDRGIVIMMTDEKLEPAAAKSMVKGSADRLDSAFHLGYNMILNLMRVEGLTPEYMLERCFFQFQNAANVPHLEDELRVLDERKAAIVIPDEDNIADYYDLRQQLDLLNKDLRDVLNHPTYALPFLQPGRLVRVKHDDLDFGWGCVVNYQKRLGPSGKPLPADEPAQNQYIVDVLLNCAIGSTPGPTKKGQAASTSLIRPCPPKEQGEFAVVPVLLSTLDGISHIRIFLAKDLKPIEARQQAWKSVQEVKRRFPDGVALLDPVQNMGITDEPFKKLLRKIEILEARLVSNALHSDPNLSTLYDQYASKQSVQTQIRSIKKRIQAAHSVMHLDELKNRKRALRRLGFASNEDVVEHKGRVACEISSGDELLLTEMVFNGVFNELTPQQTAALLSCFVFDEKSEQTSKLKEELSGPLRVMQEAARRIAKIAIESKLPLVEGEWRLGRNLADEYVASFKPELMDAVFSWCNGARFSEICKMTDVFEGSLIRVFRRLQELIRQMSMAAKAIGSEELEKKFLDALACLERSNSVAFAASLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N418</accession>
    <name>A0A2X0N418_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C005g03196 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C005g03196</name>
        <name evidence="6" type="ORF">BQ5605_C005G03196</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY72683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0N418"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17745">
        <property type="entry name" value="BRCT_p53bp1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17724">
        <property type="entry name" value="BRCT_p53bp1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04508">
        <property type="entry name" value="Tudor_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047249">
        <property type="entry name" value="BRCT_p53bp1-like_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047250">
        <property type="entry name" value="BRCT_p53bp1-like_rpt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047252">
        <property type="entry name" value="TP53BP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15321:SF3">
        <property type="entry name" value="TP53-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15321">
        <property type="entry name" value="TUMOR SUPPRESSOR P53-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15402">
        <property type="entry name" value="MELT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="5">
        <location>
            <begin position="1280"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="5">
        <location>
            <begin position="1431"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="241"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="372"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="710"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="778"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="986"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="406"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="784"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1002"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1051"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1066"/>
            <end position="1075"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY72683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1530" mass="163175" checksum="E2833FA7151B4333" modified="2018-09-12" version="1">MMELVPNTPSSQTPSQQAAPTPTPSPVRAQQQTHEAEKPEHSRIDHGGAQDESFLGVVEDSMARSFGESYLRDLLPPTQVVEERSNHNVGIGGGVDGASGTKQRIASRGEQAAVLVQGTSSVEIAQGSSPERSGESGGIASSPRYGCEGGDLNESFRTMPGMDAFHRRGDGNQTREKRDEGVEDGWYLTGDLTGDLTGELMGEMTMEMTRVGGGIQQPQNGIDRSGVDVDDLSAAQNSALLDRLAGGDDNESNQIKEGRGGEEQVSPSQKENVVPSINIGHRPSPSPTPSASASASRPPPPVSVSASISPDREESAYPSSSRAVAMNLLAGRCSASKLGTARSMTEPTSSGDFHDEVLLLPRARSVHDGLLEIPEMDGPPTSTPALSNAAPPDPPRTMARQRSYSAHPPHLALARPARVGSKHPSLPMDPPRALYQSSAVMRNRAPTPPRRSRVKDPMEDTQETPSELDPKPESEALGTSTRSVFGVRVGHDDDGVMNGDLEPTQVEADEGGEKDMTIDVTMGAGRERYQGEATDEEPDQSKDGDKTVSTPRASDGPPNKMSPTLLSSSDVDVDSLATRVTVETETYQLFAPAAPGVRFITPTTTGANIQDVTMEPLASSGVTTESSQDVDHLAGLSLGLSEIGAMSSQPAPTQFEMPATQTYDIERAGPLSFKQQESMGESARCLSSTSSNLLRAHFPADLARSLRSFEHDTTEAPHPPRAPPRGRKLERIAPPPTPALVRAHMSKGSSLETLDAQMDPTQIETCISSPAVHQAGAEAVPSSIALSTPWSSNSATEPRSERESTRPLGDAAESQDPEGHARVLVPPSEEPTQLSSAGPAPMEVDEEAFSEVGPSLPLNSRPPSIASGPVVKESVKEPQSVVVPKKKQNAVVKGKGKNRAEPPVSDGPSSESFDPIDSLPRARIRRPSARLRDSIGMSVQPAILRNPASTDPDVTLPPLPDLPATSSLSSLPQSLVTSHAAVAETRSLLPPGEANANAMSRTAKRRKTGTPTKVKKASAGRKAKTSLESKRKSAIPSTSRVTLDEGAPTVHFDERPSEPIDRDSSRATSVKASDTASRDVKPHLPKSKLPSTAPFNRVFGLWRDNSWLYPATAISVGGARVHVRFDDGSKGNLKFSEVRRLKLQRGDWVRYVGDEAGDTETQVTTLAEDVRVYRIESEVDGNDVQGHCEQDDIVAVTPARVPLADQPELARQGQIQRLLVCAIAIPPQHTAQFDDRRLTAVEIAGFEGKAPVSVKSPTLLSIPPPDKVEPLVVARQDGAGSLFARMAFIVTSTRPEQEKRAFLESMHGHGATVIDVQHLYTVETESNKGGGTKIKFQVDGLRDIDTILLLADQPRTSPKFLAALALGIPCVSSVFVTDSIEQSARCDWKQYAISTGHVQSLNASSIYTQYRAMSRPSFDAAALAQAHREGYGVFNARSFLFALPKAQIRSVLSIVIAAGATRFHVVASAEAASSAIGYDHIVLEDGSKVPSGLKNHSGVASMTWIKQCLIAGRLLAPAMMRPVQVIEVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N5J7</accession>
    <name>A0A2X0N5J7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C008g04907 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C008g04907</name>
        <name evidence="6" type="ORF">BQ5605_C008G04907</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY78645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N5J7"/>
    <dbReference type="STRING" id="796604.A0A2X0N5J7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009880">
        <property type="entry name" value="Glyoxal_oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208:SF21">
        <property type="entry name" value="LOW QUALITY PROTEIN: ALDEHYDE OXIDASE GLOX-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07250">
        <property type="entry name" value="Glyoxal_oxid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="GO-like_E_set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015936927" evidence="3">
        <location>
            <begin position="33"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="Glyoxal oxidase N-terminal" evidence="4">
        <location>
            <begin position="143"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose oxidase-like Early set" evidence="5">
        <location>
            <begin position="520"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY78645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="631" mass="68386" checksum="E6F68B45EED8AD8A" modified="2018-09-12" version="1">MVYTRPRRARAAVFASIVLCLIVVVAPTSVLALETAIVAPPDGNSSRGPDTETIPTSAGADDGETLFQPNSTEMSPEEPLLEEPHWLPLLKRARRRKPPSEDAWSGETTTRIIGKLGIGAMQAIQSSDDELLSEKSLLSLDKAQNNPLQIHNHSAWGNFCAGGTFLSNGDIISVGGQPSEHTELGKPSVAEDGFTGLRVFQPTSHRLLDNPKKVHIQSARWYASVVRVTDGSALIMGGSKKGQYNNDPKVDNPTMEFFPSKGPQFYSKFLQDALDSNLFPLAFLLSGSGNIFVVANHVAMIYDWKHNREHRVKGVPGGIVATYPGSGTAVLLPLTIKNNWISEVLICGGVFNTVNLTNPGFNVRADEPVSDQCARTSFPRGNSMSGWEVEHMLSPRIMGDPVITPDGQVLIVGGAKTGTAGYGNAIGMGEYASAVGHSNAAVPNLVPTLYNPDAPRGQRFSEKFPPAKIERMYHSTSLLTTEGSVLTMGSSPNPRILTRLTYKSRFEVELIAPPYMTKKRPAILNYPQQIKYNGHYTLTMSNPMGCDNVRVVLIDGGYATHALHMNQRSVELLVTSSNQSTITFNSPHDGTIWSPGPAFLWITVCEGKIPSKGHKIMVGDGSNPPNYKAPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N801</accession>
    <name>A0A2X0N801_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C024g09847 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C024g09847</name>
        <name evidence="2" type="ORF">BQ5605_C024G09847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ26157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N801"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ26157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="141" mass="15644" checksum="CFB6D2010BCD6955" modified="2018-09-12" version="1">MLGHNKTRWRPLKTSTSNSFFLFNWAHKLRSFGLARIATKRAKRGNKATTTSSWVKIKPLRATSAAQIKARLAFFFSIFFLFLTGAHKLQSFGLAGTATKRAKGGYKATTASSWVKVKPLRAKSAAQIKTRRAPNADSNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NAZ0</accession>
    <name>A0A2X0NAZ0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C030g10863 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C030g10863</name>
        <name evidence="25" type="ORF">BQ5605_C030G10863</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000069">
        <property type="protein sequence ID" value="SGZ09312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="1547"/>
            <end position="1713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1787"/>
            <end position="1806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1891"/>
            <end position="1910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="2675"/>
            <end position="2694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="1796"/>
            <end position="1806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="2675"/>
            <end position="2684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="2685"/>
            <end position="2694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGZ09312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2770" mass="306725" checksum="879A6F09B62A2577" modified="2018-09-12" version="1">MYLDDPDIELLDDDFERMAPLLDVRVSELLTFRFDNPDTQIQLSWSTDEPLEFDTLPRPLRAWRDKFKNREAITAARKQGYRSIAITGHRLPFSVEKIWRHIDYAERMRSVVINSQEWMKSYLGVDIENQPLIVKALEVLPSLLVEDQYTPSMILGCSASLRTLLDFVGKQPICSFVRSPPDKVYGAFPSDLMAILVASGKHQPDSPQREVLDKYIFASPLVPYRTLADLRSFVRARPLSIWFLPLCFRDHWAMARVDVGQRTWTLFNSLSHIRIDEITRNSALALFDYLELHILNTEPKQGRMAQQADGSSCGPAAINVGETELLLVPPFSAGRAHIARICQFHRLTTFATKSQHLTHDLPAPIAGIDRNELDVEEMAEIEDDEETYRRARLAKEHLKDIEYSKARPAAFAGFRAKVKQLCPGSDVKIENPRTVQCGRCRTYHKMKTRHGVTRFMKHLNKKPPCTNMRKIDHYFAVRSPAETAVQSQGKSLADPPACPGLTGKRVEVYLSKSSARGGGAPSRLKLIQRGFPRIGKRVLTRSERREIHNLEANEWTWVNDHSAPRSQWQLEPCAKCKALLRTKAFSQALHRPRAVGPTIKFTNKRLASVEALMSKVFKEHQGLEELLGTKDGKVYLRFAQGLVSGEMAGANILKGKDMRGYVRDEALLDFEHALALASPTALRVVQKTVGGVSRRTIQQPRFGLDEPHMQRIIQKILSDGKTFNLHVDDTKLRQVIRTTRVYSKDKEAEARLRGQKIFRHELVGMVGPPNVYETTQELEGIFRGPNPPIAGTKFGDYVRMYMLAPNDVSCPAQDFAAFVIGDSPSSSEAAHELESVIQFLVNAGVGHLLASISADGAASEGVLQRVMAERLGGDEGYTGEGNRRRELPFDWHPFKWATPTCFNRDEKHLSKNLRNACDSGARAIYGGTGCYHNATHRAFSEATLALACRLHEDGKFDADAIVFLFLCGELHDAIQNRSLQPIERIKMLLTVRYTFEGWLTFVRNRPGHNAQSFIAKETLDGMRTVIDANIALIRNYRDFWPEEAFISWRHGTEMIEHFFGGLRKVVQEFDALEFLQVMLRLRAQRSGPANSSHQVIMPGDTDTVVSGGTTSIVYVKPRDIDPSCHLRNAGGWSQWINDVRGALGGDYWNCTLATPIQKPNARTDLEHANFQAIALLRRSVSLNIKKQIKDGFDHTPTDVLKMIKKAVAAGTVTDIFIKLQALLDAGPPPSGVDAFEKYQANTIELFNTLSGYNLTFDQVISIRLIHFGKDLYKEYYTQALRQDLDKLPDPIEALQTLQTQAESTPAHKPVAMVASLTATDRSSSTPSAPCRHCGGPHWNRKCPVKDKKSKASSAPSASLAAAPDISTLVDGPVRGYLTAAMSTLAKPSLILDSGATHHIVNDRACFTNFRKCKPAPLEGITGEAVNSIEGVGSAVVRSFDGSIGQLHHALFVPSAPVSLFSASRANAAGYDINLSRGKATVSVDGSICHTGEITNGLYHMHASLVDVTTLIEQPVNMEVALNADLKCDTCQAGKITHHPFPTVASNRSAQPLDRVHMDLLAFDGAVSLGGAKYALVIVDDYTRYLWAIPMSHKSDTFAAFKSWLAKVERSSSRKLLAVRSDNGGEFLSNEFSSFLEEQGITRQLSIPDAPQQNGVAERANRSITEGVRSMLHQLGLSHALWAEALATYVYVKNRSPHSANSGVTPHTRWHGSKPSAGHLRVFGCRAWKAATTEARSKLDPRGIPLVFVGYDLESKGYRLFDPATRQVFKSRSVTFFEDEFPARREGITAAHAPVAGDDDDDDDDDDEVVVLPDQHANQAPPDQAELPAALCFDAPGPAWQPPVGSRPRNPPARYGALASLRSTPSAFAFSLGKEVTELVADLEATGIDASTANRPLSEPEDPFSLPSSDPTTWNEAMRHPHAAAWKAGAIEEFRSMKDDLRVFSVVGLSSVPKGATILPSRHVFRTKCDKAGKMVSLKNRIVAQGCAQGPNSFNNTFSPTAKYTSIRTLIAHSASKGHHIIQADVDKAYLHGVLEEEIYMRVPTGIEGYEGKCLRLHRSIYGLKQAGRVWNDTINATLASLGYRRLACDECIYRHEDAGGDHYIALYVDDLLFFGPDLGEIDRVLDQLNTLYGVKRLGPAEWVLGVQVVRHDDGGISLLQRQYLLDVLDRFNMSDCNPCKSPMEANLQLSPEPDTDSADNAIYRSMIGSLMYAVVATRPDLAHSVGYLSRFVGKAGDTHLEAAKRVLRYIKGSLDLGIHYTRTSAPLLGYKGYSDSDWGSDIQTSRSTMGYLFKLAGGAISWSSRLQPRVACSSTEAEYLGLSHAAKEAVFLRSLLTELGLDTSSPLRLLGDNQGAIALTQNPVFHARTKHLRMLEHFVREHVRNGEISVTYIPTHDMVADIFTKPLPRVVFQRHCDAIGLRRISGQEQGGVLSTSLFDFYSKVSALLGLLRKLKTETAGSRQGYYHMYDRLDDLDLVAMRTYPSDVEIRSTSLVAAGLAKELLLGLRMWDTIRYQKSNQLEEDIPINASEPWHFEPEDAEPLSYIADLVRTLNGIRTKTCQGLVVLDSNAVRSLAALGLDNDAALLAVQQAYDEADAQAEERFLLDAIVTANESLPATLNGTSILSQAQIIRLPSLLRHDSRQLALDLKSLIQQPRAHQCTHLRAVLLKGRHGATTSTAQDSDPTSKAKLSEHGEVHSSVLRGLVQSMGAARLEAVSGVARSIRWTGQGAFSRFSTANETDNMGYIEDGRKDVSYNCVLCTYGPESAHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NBA3</accession>
    <name>A0A2X0NBA3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C046g12276 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C046g12276</name>
        <name evidence="3" type="ORF">BQ5605_C046G12276</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000112">
        <property type="protein sequence ID" value="SGZ30941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NBA3"/>
    <dbReference type="STRING" id="796604.A0A2X0NBA3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF2">
        <property type="entry name" value="MANNOSYLTRANSFERASE KTR5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ30941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="446" mass="51309" checksum="CE5018A5633436DC" modified="2018-09-12" version="1">MPHAVDTVIPIELHHVALDSYIETLPVRLLARMAIAAWVLTVAVLALAGLHPSPWLSDNVALVLSPQQTNRLDSHRYALSTTSTSSPVRGCQNPEIVVTEPRENAAITLLVREQDLAELLPTLRNFEKRFNRQFRYAYVFLTAPVDPPFSTMFQEQVVASLPEGAVVEWATVEPRYWRIPETMDVANVRSGFEQQQKDGVQYAGREGYHHMCRYFSGLWVRTAALQKYDWYWRLEPGVRFYCTISYDPFRFMALNHKIYGFVITIVENMNTIPTLFDSILELVQKHGLVPGSRLWQFLLKKGDPGAYSGCHFWTNFEIGDLRFFRSEPYQTVFNELDQAGGFFSERWGDAPVRSLALGLLSDVDRIHYFEDFAYQHDWFMHCPQEKGLGCDCQCPVYSKDPLPKNELTDVDHDWRFSCLDRWKETVGTSASSIHPLPPNNKRPPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NEL1</accession>
    <name>A0A2X0NEL1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C024g09899 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C024g09899</name>
        <name evidence="1" type="ORF">BQ5605_C024G09899</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ26372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NEL1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ26372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="54" mass="5471" checksum="CF18698CAAAF87ED" modified="2018-09-12" version="1">MNMNGSTSGSTDDLFSLVLNSDTASSFGAATAGDAPLSVQQHIERVVGRAPDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NFX2</accession>
    <name>A0A2X0NFX2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C027g10322 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C027g10322</name>
        <name evidence="6" type="ORF">BQ5605_C027G10322</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NFX2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35, MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGZ28362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="454" mass="49646" checksum="14CC9EF50A4E4FD9" modified="2018-09-12" version="1">MDLDRPPPSPELQLLVRRAVSESRRQYVLGTTLLLGVVLLWVSSSFLMNSMFTSMNYNKPFLVTYLCTATFTFYLIRPTWTYLQLEHEKKRIAPSGSITVETTSRPRAHTATKSSERLASMLDPVGSITDSDGNVYMRPDFAFRARSQSRSISRPRSLLASNANGSAVHIAGRPLSTMSNDPPLTIRETASLALLFCGLWFSANWSMNASLGYTSVSSTTILSSMSGFFTLAVGSCVGVEAFTSGKLGSVVLSILGVIIISKFDSTLPPTTAPFPLLGDSLALLSALAYAFYVILLKVRIRTEARVSMTLFFGFVGLFNILLIWPIGVILHLTRIERFELPHGGMLWLSIAINAMITFVSDALYLKAMLMTSPLAVTLGISLTIPLAIIGDWWRGSVVGWKTVLGGTLVLGSFLANGLMDLRSAKQVLEEVNGDSSLSSDDGSERERLLSERRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NG24</accession>
    <name>A0A2X0NG24_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C027g10382 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C027g10382</name>
        <name evidence="2" type="ORF">BQ5605_C027G10382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NG24"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ28588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="160" mass="17978" checksum="5D04EFC3B0BBF723" modified="2018-09-12" version="1">MTQVGQTKENITVALSLDNRPNQPGNLTLHSAPASSWAKHNFDFQFSGPAQQCGTQALCRSFEAEHRWNAYKCEEEQNEYKYVLDVDGNGRSGRFRHLMASNSLVLAPRSAASELSTERDTDVLLVQYTRAMERDPNDYHSMDYNESDSAAASTTRRLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NHI5</accession>
    <name>A0A2X0NHI5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C047g12298 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C047g12298</name>
        <name evidence="9" type="ORF">BQ5605_C047G12298</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000113">
        <property type="protein sequence ID" value="SGZ31075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NHI5"/>
    <dbReference type="STRING" id="796604.A0A2X0NHI5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10289">
        <property type="entry name" value="GST_C_AaRS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02799">
        <property type="entry name" value="tRNA_bind_EMAP-II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000047">
        <property type="entry name" value="tyrosine--tRNA ligase, cytoplasmic isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053836">
        <property type="entry name" value="Arc1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051270">
        <property type="entry name" value="Tyrosine-tRNA_ligase_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586:SF33">
        <property type="entry name" value="AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586">
        <property type="entry name" value="TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21972">
        <property type="entry name" value="Arc1p_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="8">
        <location>
            <begin position="273"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGZ31075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="444" mass="47333" checksum="74331244326EBF37" modified="2018-09-12" version="1">MASLTLTHSTCAGRAAALLAAVYGQYVPDLTITHHDKDKLEFKSASSQTYTKLVDIAKALLEAAGKTNDALGGASDQVQQSVLHYLNLVDENKFDADKGAEAADAELRTKTFLVGESVSAADLGLFAAVHPTVASATHNQHLSHPSLSRHFNHIQNLRLVAPHLSTVFTSSPEPVKIDVENVPVVEIKQQAKVKKAPAAAAAAAVATEAPKEAGKQAKADKAQVVEEVKKEVETVAPIAAGEGTTTSSAKPKKEKAEKVKKPAPAAPVVEAPAPWMIDLRVGKIVEVAVHPDADSLYVEKIDVGEEEPRTVVSGLVKYMTLEQMRGTTLITVCNLKPANMRGVKSSAMVLCATAAEGKEAGIEFLSPPEGSVPGDRVYFEGFEDQQALEMLNPKKKIFETVQPGFTTLENRVGAWVDKESGKTYKIVTKRGECRTQSLVGASLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NJ92</accession>
    <name>A0A2X0NJ92_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C062g12753 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C062g12753</name>
        <name evidence="1" type="ORF">BQ5605_C062G12753</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000138">
        <property type="protein sequence ID" value="SGZ35535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NJ92"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ35535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="143" mass="15926" checksum="5ED4E0B8EC0D13B1" modified="2018-09-12" version="1">MGAKGGYKATTASSWVKVKPLRAKSAAQIKTAEHLTRTPTGGEYCCRFTSQEREQRYSKIRQERLEKEGGEYTENFFFFVFFFFLTGAHKLQSFGLAGTATKRAKGGYKATTASSWVKVKPLRAKSAAQIKTRRAPNADSNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NSF8</accession>
    <name>A0A2X0NSF8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C017g08458 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C017g08458</name>
        <name evidence="2" type="ORF">BQ5605_C017G08458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY20078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NSF8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY20078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="273" mass="29866" checksum="30B54FFACE525247" modified="2018-09-12" version="1">MNMTIAELLAFDVAPADASLHIELSKDELTHYSTLSSTRGRVATSSCSTQGRPMESSDPTRAEAGVGVSNTEEGRSTTHSCVLKGLVQSMGPSRCEDIAGTTRSLNEIQKNAYIEDGRIQEKLPERDKQYGALAQRYPHFGSLDGAVTAATPLETGSLICFSLKCGMHSLSCDQTVLGEEALSIGISTRSDNQPLQPRHARLVGSALKCRRTGASPHQENILTTKQRASQQSKEGLFEAWSHALHQPKRRAPQATFDRPPRARKRSERVFEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NTZ5</accession>
    <name>A0A2X0NTZ5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C019g08938 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C019g08938</name>
        <name evidence="1" type="ORF">BQ5605_C019G08938</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY23438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NTZ5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY23438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="145" mass="16434" checksum="5D050AD32714CEB5" modified="2018-09-12" version="1">MEQHSLGAQARSGANFFVSKARGGDWCRSVGSSPFRLSPRDQRLFVSPRIYKRDWFGLLISGPAKTVRSAPPPSLRVSLQHLGERCYCNSRSFCGSWGIDPTVQDHPMRLFHFENRRQGRAFLAPDRTVLYEATSRVRFESGDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NU24</accession>
    <name>A0A2X0NU24_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">GPN-loop GTPase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C019g08968</name>
        <name evidence="10" type="ORF">BQ5605_C019G08968</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6 8">Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimers with GPN1 or GPN2. Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY23684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NU24"/>
    <dbReference type="STRING" id="796604.A0A2X0NU24"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17872">
        <property type="entry name" value="GPN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000552">
        <property type="entry name" value="GPN-loop GTPase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030228">
        <property type="entry name" value="Gpn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF7">
        <property type="entry name" value="GPN-LOOP GTPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY23684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="319" mass="35726" checksum="DAF61D959837603E" modified="2018-09-12" version="1">MLLPHWLVQADVLRFTPLRSQCDVSPTTTIHTRFQRWTHLIDAVLVTGPAGAGKSTFCASLITHAQSLGRSVHLFNLDPAADKFEHPPSIDIKDLVSLEEVMDDLQLGPNGGLIYCFEYLMNNLDWLQEQMGDYDDDYASTLIIDCPGQIELYTHIPVLPKLAKLLTSTMGIQLVSVYLLESQFMEDTAKYFSGVLSAMSCMVGLEVPSVNVMSKMDLVKKGTTGAKRRKQVDRFLDPDPELLRESANRTTNPKFHALNSALVQLIEDFNMVQFLPLDVTDEESIGVILSHIDNAIQYGEHEEPKEPHDMDEGDFDVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NVJ5</accession>
    <name>A0A2X0NVJ5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C012g06950 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C012g06950</name>
        <name evidence="2" type="ORF">BQ5605_C012G06950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NVJ5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY16687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="376" mass="42975" checksum="41B8DEFEF7BC1984" modified="2018-09-12" version="1">MTVPEPPAATRVKGIPLRVLIDRREHFLPDMMFRFFEYAVRQPEARFYKEAEIIWQAVSETTWRELRAYTKALAIYCKQVGTRLEQRSSWNIFSPDVWAAWLELKRFYLGERGLCNDYWRIIKYSGYLINALRDRFISQYNAKHPKLDPPLRRSDNLILRLGSLPSFRKDRVAYFQTPDPTPGPSGFLWGELDHFKRRGGIVFDGKTFPTDFDVVTDTRPNFMPKDDEILGIAALLPTCTDSESQETDSGSHGSQGRTDALFISLGLCEGCGSSPLACCLRWMAQLHARVMLSCLLTTLRSSISFRPHTTTICPLVAVVKLHYTVSQFRSRIRSRSHPDVDRTNSLPRSRWGSLPPSSTQSHLLSDSVCIDPHANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NY95</accession>
    <name>A0A2X0NY95_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Acyl-coenzyme A oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">BQ5605_C017g08432</name>
        <name evidence="18" type="ORF">BQ5605_C017G08432</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2</text>
            <dbReference type="Rhea" id="RHEA:38959"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="ChEBI" id="CHEBI:65111"/>
            <dbReference type="EC" id="1.3.3.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; peroxisomal fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY20009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NY95"/>
    <dbReference type="STRING" id="796604.A0A2X0NY95"/>
    <dbReference type="UniPathway" id="UPA00661"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000015">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000003">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029320">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF250">
        <property type="entry name" value="PEROXISOMAL ACYL-COENZYME A OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14749">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000168">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12 14" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-coenzyme A oxidase N-terminal" evidence="16">
        <location>
            <begin position="19"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="17">
        <location>
            <begin position="290"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-terminal" evidence="15">
        <location>
            <begin position="504"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="443"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF14749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="SGY20009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="703" mass="78055" checksum="9BD3CD098E1FA93A" modified="2018-09-12" version="1">MSQTTKDLTEARSRMTFDPTILNKVLNEGSRDSEMRARVAKIVSEDLAFDKSKKAYLSRSQRLERGLAVTRRLMDLVDEHDLDYMEYIEALACVDEPIGIYLHEIAFQPVIAAQCSDEQQAIWLPKCYNHEIIGCYLQTELGHGSNVQQLETTATYDPKTQEFILNSPTISSTKWWIGALGLLATHGVVQARLFINGENYGPHLFLTQLRSLEDHSLMPGIQAGEIGPKVHQGMSAVDNGCECCLRRIYSSAQWARFDHVRIPRDQMLNRFAKVSPEGKYSKPPHDKLSYGGMIFIRAQMIGNLAWKLAKAVTISTRYLHTRRQFADPELKRGEPGFGIERQVITYPGVYMRILPQLARSIVFITAGKDMSNLYSSMAAQLAEGDTTLLAETHAVSSGLKTYVSAGTVDGIEIVRRAMGGHGFLDASGVGRIYASELPSVTYEGDNFILHLQVARAALKTYGAYKENPSGTKLSPSSAYFSALGGKLQPSLPIQATSASWQSFETQLQVISLRAALQVDRLERLLRTGKKFGDLSHECIEVSKAVVEAFLVRRMIEAVTNSSEGLLNQGAGPNEKKVLAKVVHFFNLHTIEQALPSLLEFGILAPAPPLSATLDSPVEALRALVNSHAQALLPEAVGLVDAFNFSDWELDSTAGRYDGKAYEAMLERAKNDLDSNVGNEEERKRMYREHIKPILERGKRLSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NYG2</accession>
    <name>A0A2X0NYG2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C003g02266 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C003g02266</name>
        <name evidence="8" type="ORF">BQ5605_C003G02266</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NYG2"/>
    <dbReference type="STRING" id="796604.A0A2X0NYG2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000022">
        <property type="entry name" value="protein EXPORTIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041123">
        <property type="entry name" value="CRM1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041235">
        <property type="entry name" value="Exp1_repeat_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014877">
        <property type="entry name" value="XPO1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040485">
        <property type="entry name" value="XPO1_repeat_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF2">
        <property type="entry name" value="EXPORTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08767">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18777">
        <property type="entry name" value="CRM1_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18784">
        <property type="entry name" value="CRM1_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18787">
        <property type="entry name" value="CRM1_repeat_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01102">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="7">
        <location>
            <begin position="34"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1064"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1064"/>
            <end position="1073"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY39697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1088" mass="122331" checksum="921365386C85F452" modified="2018-09-12" version="1">MDAILNFSVPLDVNLLDQVAQVFLTGRGTEQAQASTVLAQFQEHPDAWQRVPEILERSASAQTKYIALQIMDRLIKTRWKILPDDQRSGIRNFIVGIIVKSSEDEATLRKQKSYVNKLNLILVQILKQEWPHKWPTFISEIVSSSQSNLTICENNMVILKLLSEEIFEFSAEQMTTAKTKALKAQIHLKFAEMAASQCQEFSEVFSLCVEVLEKADKASLIKATLEAMLRFLNWIPLGYIFETPVIDHLIGRFLEVPEFRNVTLKCLSEIGGLQIGPEYNAKFIILFNLVMTSVNKMIPPSTDIAGAYESSSDADQELVLNLALFLTNFLSVHVQILETPQHRDVLLNAHLYLIKISQVEEREVFKICLEYWAKLVADLYDEMQKFPMNTMGNPLLNLGMGGPGSSGVGGSGSGRREIYTEVLSNLRLVMVERMAKPEEVLIVENDEGEIVREFLKEIDTIVLYKSMREVLVYLTHLDVVDTEMIMTEKLSKQVDGSEWSWSNLNTLCWAIGSISGAMNEETEKRFLVTVIKDLLGLTEMKRGKDNKAVVASNIMYIVGQYPRFLKAHWKFLKTVVNKLFEFAHETHEGVQDMACDTFIKIAQKCRRHFVMQQSGEQEPFIDEILRNLQRITADLSPLQIHTFYEAVGYMISAQPNKPQQEQLIASLMSAPNAAWDAIMAQAATSGTDVLSNPENIKILSNVLKTNVAACSSIGTFFLPQIARIYVDLLGLYRAVSGIISATTAEQGLIATKTPKVRGLRTIKKEILKLVGETYIRKAEDLEQVNANLIPPLLEAILGDYKQNIPAARDAEVLSTMVTIVNRLGPLMTDKIPPVLDAVFECTLAMINVDMSDYPEHRVAFFRLLRAINVNCFDALLKIPPQQFKLIMDSIVWGTKHAARDIADISLNVCYELIDNIVAAGPETSNGFFQAYYLSLLQDMFFVLTDADHKSGFKSTSIVLARLFRLVGSGDIQAPLYDPATIQDPTMNNSKFVSEYCADLLKRAFPHLQPAQITAFVTGLREQNNDSVRFKAGLRDFLISMREFQGADDTAELFADEKEAAIAQKQAEERERAAHVPGMIKPSEMEEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NYR2</accession>
    <name>A0A2X0NYR2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C016g08070 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C016g08070</name>
        <name evidence="6" type="ORF">BQ5605_C016G08070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY20477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NYR2"/>
    <dbReference type="STRING" id="796604.A0A2X0NYR2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000047">
        <property type="entry name" value="NADP-dependent L-serine/L-allo-threonine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901:SF1">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="5">
        <location>
            <begin position="11"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY20477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="273" mass="29095" checksum="1A8AFB5A49164E9E" modified="2018-09-12" version="1">MSIMFPRLAGKTVLITGASGGIGAETAILFARCGANLVLTARRQPQLEEVAKLAKEANAQGGTGQGGQVECLTLDMQDRKAVKGLLDRIPKKLRLVDVLVNNAGLVHGTEKIGDILDDDIDTMIDTNVRGLITLTQIMVKEMKSRSPTSGHIINLGSIAGKEAYPGGAIYCATKFAVHAFTTSLMKELMSTRIRVTLICPGMVETQFSVTRFRGDKSAADQVYEGKEPLVAQDIAEEIVWAASRPAHVNIADVLIFPKCQSGAGGLVHKGPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NZJ8</accession>
    <name>A0A2X0NZJ8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C019g08942 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C019g08942</name>
        <name evidence="2" type="ORF">BQ5605_C019G08942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY23472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NZJ8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY23472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="350" mass="37712" checksum="F337BD167F3C15C7" modified="2018-09-12" version="1">MAGDGLPLNAPSATSSPPARPPLASPPPEYDATPAKSAPSPASEKHPTPPWISRPSTYLKLLLALFLVYHLHLPSFTRPTSLPRIEAIAYPPQPGQDIVYGLRVIIPITSQGKPDQLLLEIGKIPDDQLKGRVLDSFVGLSDSWFFFKIQSKEDTHYLLATLFMANLVTRQEANQILRKGPVSHTTGSTNSNSLLPIAIHRIPSLMTLSAAYMAGAEVGTRVLFRTVRLNPDDKITPVVVGVGSVLGSMILFSKSSSAEEGDVTVRKMNTEHVRMLGMGSGVGALMNAQVGGEGTEVAMIKVLSDKERLNHPFFAESAGGSGFVSSQAFGRLPPEEEDDWLDTAVARLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NZV2</accession>
    <name>A0A2X0NZV2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C018g08605 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C018g08605</name>
        <name evidence="1" type="ORF">BQ5605_C018G08605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY25359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NZV2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY25359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="53" mass="5686" checksum="2F0ADA979FF1701C" modified="2018-09-12" version="1">MSIDRLQTVYLSIACNSVVSGAFAETTDRVALGPLVRTPDPALDRTSCTRGEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P0Y9</accession>
    <name>A0A2X0P0Y9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g00999 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g00999</name>
        <name evidence="2" type="ORF">BQ5605_C002G00999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY29003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P0Y9"/>
    <dbReference type="STRING" id="796604.A0A2X0P0Y9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY29003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="325" mass="37158" checksum="59A82261A958BA48" modified="2018-09-12" version="1">MDEEDEDHDKPEDFHDPEESLDGEAEVALAPREGYAIVLPIIAAIMVDVLDTPPLFHDKLSYDAYCAAVFAEEDIEIPKTFEEAMKSPYRNHWIEAMVSELLQFDHHGVFQEVTWHEGIRVLGTIWVYNIKRDANGKIIRFKALLVARGYMRATADACLYIKHSGTSFAIITLFVDDGLIASNDQSFLESELVSLHKAFKLKRLGPVSYFPVFEVHRTKDHILFHQRRAFTPMDDRPSLRIDTTPFADIPMYQSAVGSLQYASTRCRPDIAIAVRAVAQKNSCPTVDDWAAVKRIFRYLNSTVDWGILYRNSYSGDDLLLRLLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P1N4</accession>
    <name>A0A2X0P1N4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g04027 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g04027</name>
        <name evidence="1" type="ORF">BQ5605_C006G04027</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY55450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P1N4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY55450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="126" mass="14362" checksum="1C750A8B0803CC87" modified="2018-09-12" version="1">MKARLSETIDDRLVEGNLGWPTDAHNTYFRDNWVLLATVCYLPSARRWFPILTTTQGINGLTPNQIATSRSDTRMRWRCTGADSACNRPDLIARVFEAKSGNKRHAGCFGDECKMNRFCFFAVLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P267</accession>
    <name>A0A2X0P267_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C006g04247</name>
        <name evidence="14" type="ORF">BQ5605_C006G04247</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY57260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000007">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="12">
        <location>
            <begin position="594"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="13">
        <location>
            <begin position="1136"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="11">
        <location>
            <begin position="1448"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGY57260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2551" mass="286151" checksum="4AEF541ED881895C" modified="2018-09-12" version="1">MPTPTAPSHSPMYKPNDPPQLHSTSMEALREYFMRLDFYNRRIARTPITSDYDKIEGAGMGLQVFALKTWFTQGLSKHLAKPYTQFKSELIRQAVPADFVWTQLAKLHRLRQAPGHDIDAFQEFSDQMRSLQMEIGFQVVSDQEVAKLVLLGTNPELCRILRTHMVSSLAGWSDLPLEKLALDAPVVPTSPEAAEVFSDAHTDQPLEFDYQVFERIGREEWSVIAQRRQAIATQVSALQQRPTYSRPAAALAAPHVATAATGHSPITGGPRPVARLTVNERAYLDQNHGCYRCRTLNADHISRNCPRYLSPMGASATPSTPTSTAPAPRPGPRMVAAIRTFQETGDSTVFAGLSSDSEDDNDPSYTPHPFPPLPISLAGAHGTLLASALVDSGSPQTFLSEELVQRLGLERRALEQHSKYTLAMQNQVPTVFTCTHFVRVPLELANGLWAAGPTYAEVAPLGKDLAIILGGNFIYRHKMELGLFPQPHLTCKANPIHAIDLLALSSQPCAAARVAAIAPVSDDEEQLRLAALDHRLRAEFADRFPADIPPVHSYQSPVRHRIELDTSSTVVNLRGYPLPKKYCEAWYLLLQEHLTAGRLRPSRSAYSSPSFIIPKKGCDVDPTIAPRWVNDYRELNKHTIKDRTPLPLPDDILSTCSNAQFWAKIDMTNSFFQTKMAEEDIHKTAVSTPWGLYKWTVMPMGLCNAPATHQRRVNEALQGLLGTICFVYLDDITILADTLEEHKARVRQVLDALRRAKLYCSPTKTNLATAECSFLGHIINRAGVHADPKKIQRIEDWSLPKTVKELRGFLGLVQYLRKFIPGLAEHTAALTPLTRQGLSSIATLWTPNKVRHFKAIKAIVTSLDCLRPPNHSANAAPFWVMTDASNQGIGGVLLQGQEWKVARPIAYWSRQYIPAERNYPTHKQELLAIVEALKEWRIDLLGGHFHILTDHSTLEHFQTQRTVLSCRQARWLDTLAEFDYDLQYLPGEDNIVADAMSQYSFTDPLPTLVAAVSHVKLSDAVKQQILDAYETDPFCQQAMSNIGSVTSDFKIVDALLYLRGRLIIPSLAPLRESILHDAHDAQGHLGDMKTYRTVQQAYFWPNMSRDVKHYVQQCDSCQRTKARTTRIAGKLHSLPVPMRPMADIAIDFVGPLPANKGFDRVLTITDRLSGYVRLLPAREADTAAEVAARFHEGWHRLFGLPQSIVSDRDKLFTSKFWTALHKRLNIKLQLLSAFHPETDGRSEKTNKTAFQILRALVNKEQSNWAECLAVCEYAINSSLNVATGKTPFELVLGYTPSLAPLARVDGDDNLPSVEELLALRFQACEDARDQLAISKVRQAAQSNKKRQDEPSWAVGDLVLLDSSDRRKRLHTRKRRAAKLMDRFDGPYRIVKAQPEISSYTLQLNRDDAAVPFFHTGKLKTYRKNDTALFPNREPARLGPVDVGGEPEYIIEDIVDERIRAGKQQYLVSWLSWLSWPSDSNSWEPAEALEDTEALDRWEHRNEDTALRQVVRDEPSPPALLVGGDWNCVESQPLDSENQNGTNYGGQEMRDLATANNLFDAYRLHHPKGRATTNRSAPGTCRRLDRIYVSPDWADLFHDHKIWAVVLKSTHSMVVARFQVPGAIDIGPGKFKLGLHVIEGDATCEYLTSIVRTLYNKALLQTPNDPPAAWTSTKHRLLPELQALARTFARFRRGGSEQERADHSRYGAALRSRLDPSLAGPSSIFIRLRKVRASDLIPSLTVNDVVHSDPDSMLGAASDYFERVYEDRPIDDAALKVIIDGLASTRLSPADSLKLEEAYPLEEMTKAQAACKSNSSPGPDGLPVEFYRATWPATGPILRDVINSIPTEARQPGPLPRNTAHIHLIHKRGERDQLSNKRPISLINADERIISQAHNQRLAPLLKSLIGPTQRGFVPNRWIGTNIAEVQCLMDPGLPGSTPVSDMLAVMDFEKAYNHLSHPYLDAVLCAVGLGPKARQWYRATYTNQSASIFLNGWLSATFDILSGVRQGDPLAPSLFVLAIEGFACQIRLRVKGIDIAGLQNVRELLFADDACCALYNLSDLDHLNRAIELYERASASKLSNVKSFLYPLEAFQDRSIAPDLGTWRLSDSQFRYLGIQVGVEIAEDAGWEDVKASTIARIRSVPMYDLPYAAKCSIINIYCYTKILYYSRFLPAPKSVVKEIEEAAMLAIHGRASDGTQRRPKVSRSRLCTPLDHGGFGLIDLPRRLAIDHAKWVFQLRAPDGCFTRHLFDIRIRLQAPNEPTPFTLSRPAPNQHRCPWIWIWWAYFCHPPPKWDHAVRKTTKLLPVRWVRYFEAWALVTTLNPPELSKSQNLEQWATHVLYFPAGHGIQLSVNPTLFRGPDGEVMTPSSFVNASKRHQVFIFPPIFPKGHQKVFDLPEQRWNAWRKALRKVRRVHSDAEDTGHLLSLGSLHPGSQVASPTSPHPNNRSTSCVMCLSEAPECLVHLAVGCPFARRLWSALSPTPHPVFVDFVCPVVSRSERGLVELRVLFFHSIWKLCRRRRFSSDLLEPITETEFEGLRASIQESKGRLVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P4U2</accession>
    <name>A0A2X0P4U2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C004g02961 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C004g02961</name>
        <name evidence="2" type="ORF">BQ5605_C004G02961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY69115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P4U2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="755"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="892"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
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        <location>
            <begin position="216"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
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            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <begin position="313"/>
            <end position="329"/>
        </location>
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            <end position="373"/>
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            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="664"/>
        </location>
    </feature>
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        <location>
            <begin position="669"/>
            <end position="683"/>
        </location>
    </feature>
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        <location>
            <begin position="685"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="758"/>
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        </location>
    </feature>
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        <location>
            <begin position="772"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="909"/>
            <end position="925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY69115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="943" mass="100455" checksum="A43319173DA277F8" modified="2018-09-12" version="1">MGTKTTLPGFLHASSSSHPPTTNKLAFSSSPSASRKSSHILILDDSSNTSLLSSDDGDSGDDDAVIVTSVGDAEIPAPRRDGNGSTNDGVEDVCLAYRGECQCGGARGDPVFVSPLGNDGSSSRGSSPTSNSKGHPRFSGKTLTGSPAPASARASPELGEIPNRQREDAVDESEEEGDDDDDDIGRPRLELQKIHNSHIAALPATLPPLPTLPTLFTNKAASPSSMATSPKPTPSPPLVSTSGTSTRICFGTTTPQRLTLRQVLALSAKEAESASASAQSSVDGDALDDERYRKIADARTWMKSQDPDSSDLSGDDDDDDGPEDVVMDEIDTRMEKSEEKALRKEIEEKKRRFGSDSDARSEARSEARSERNKNPKPTKVVEETEEDVAAAWEANVEALNRVRARTLGEAKGGVVAADASIEIDEDDELGVTDLPIVGGSGVVTWSDYEDLDEFETIDTTDEEDANIVIPREEEHIEIPEEQEKSLAMDLEEELEELLAISESVVGPIRHDELESGDMWFEAVSDVEADGGATADVENEGDSDDDGSDDDEDESVEGGETLLFVDGIEGWTTAAGAMAALRRRAESGFESHDDEAETDDDEDEDGEEDDDDDDDDIDLLELDDDGGETTDSMASDALVTRFGAPSRKVAADFDDDSGDSTDSDPEVFKSSNAVASTSSVVLTTEGDAKGKETSDGRGKDPAEPSPRAVPQDATTPQAPAMGVFVAKRKNRSTKKAVKVVVIDASTALVPSPFSRARKSQLDRLTRTARADSKASTSTGSISGETVEAEMEIEVEFDLDELLNDDLLESLSPSSATSISTLPTTGEKVKSTSKGLSDFARWSRVPIGAFRSRTTPHQVAFNYDEFDLVHGGTARTTLSSPGVPNYSTKRSVEKRMLTSPVMGPSSVSAKNGKKKGKNGHGNKRPKLGHNAISPFVAAPKNSPWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P4X5</accession>
    <name>A0A2X0P4X5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C004g02991 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C004g02991</name>
        <name evidence="2" type="ORF">BQ5605_C004G02991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
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            <taxon>Microbotryaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY69301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="100"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY69301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="155" mass="16792" checksum="6B10CAAA8466D97E" modified="2018-09-12" version="1">MFAARQALRLSRPSKLALQDARFTIEREPSLSRIPRSCNLCIHPAKVDYENLTFPLYFPQTRSYATQEPTNVQRGQSKTPFYIAGAVIVLGLGYTLGTKGTPATPAVKGMQEATHPKTPGAREAAGLNADPHDRPSTAGGDQKAKDENVKATKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P5P2</accession>
    <name>A0A2X0P5P2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C001g00256 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C001g00256</name>
        <name evidence="1" type="ORF">BQ5605_C001G00256</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY45167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P5P2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY45167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="68" mass="7489" checksum="DBDDE81EC79FC3A6" modified="2018-09-12" version="1">MPDPPGPPPHPPNAPWAGDVLRDESLNTETRETVTGGTVNPPAWSAQASQARLDHEKSMQKAFFFFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P6J3</accession>
    <name>A0A2X0P6J3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00705 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00705</name>
        <name evidence="2" type="ORF">BQ5605_C001G00705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY48848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P6J3"/>
    <dbReference type="STRING" id="796604.A0A2X0P6J3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="420"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY48848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="622" mass="69123" checksum="C2967BE85B3372E0" modified="2018-09-12" version="1">MLDDSLDPRLRGSLENFLNESKLMEEVHDEVGRLLRSDRPCGRIVCTNSPECTATIHDLRIRVLEPLLLFVLKRYYDSIGDSNTRQRPNSPYYLRFEAPPRSHPPGITLALMRGNGTCLFRFSIILEEDASFMSNGAQPNLFARDDECKFHLHHNGPIPLDLGKRSHGAQAMLNKLAFLMESANERNDKTGEVEVPVGFGMMISSHFVILAEAVVNPQNSQEMGILYSHIYTTASRRPPIPLQEPFLFDFISVALMFLAAGIDHIATAAPPSPEALQLLFAHSSDPQELDRTVGATAYPGREGNITATTITAEDFWRTGGHVVQVMLDTSVASIAFVWEHSSDQLDPFEAVAFKLSETSIPNEPPVNMSEFKITLSLKRLSPALLEYLSRELYDDEGRSPLLRASLSVLDRCDLRSLPQIRIPQLLAIGGYGSAYGGQLRTKAPAGSPSQRSNKSVQAGIAPRLLAGLDSTKSEPIPQHKVMPTDTPMVIKVFDGWGAGIRESLFYEHVFPLLPKEARKLLPSYYGTYLQAGPSRSIALVMEYGGRQIRDSDLVPEFDDKVRQAVQMFARLGIDHGDLRRDNVLLRDDGSLCLIDWNLAKLVSHIIPLIGLQVPPLHGPWRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P6J8</accession>
    <name>A0A2X0P6J8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-lactate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.130</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C001g00606</name>
        <name evidence="5" type="ORF">BQ5605_C001G00606</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>methylglyoxal + H2O = (R)-lactate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27754"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="EC" id="4.2.1.130"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="4.2.1.130" evidence="1"/>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY48035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P6J8"/>
    <dbReference type="STRING" id="796604.A0A2X0P6J8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019172">
        <property type="term" value="F:glyoxalase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903189">
        <property type="term" value="P:glyoxal metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03135">
        <property type="entry name" value="GATase1_DJ-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006287">
        <property type="entry name" value="DJ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01383">
        <property type="entry name" value="not_thiJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF12">
        <property type="entry name" value="PARKINSON DISEASE PROTEIN 7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="4">
        <location>
            <begin position="241"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY48035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="431" mass="46001" checksum="84D98A39BF811B1D" modified="2018-09-12" version="1">MSEGGAFRKLVRSLSRSNKDNDRHHNKTPSPPLGSVPMPSTSIDRPERTSSRHNAKPSGGGARSPGFNNLSTSPAPDSYFPQPPAQTVHDSEANGRARHPDSRGARANDIGQVTHGMAAPGVAFAPSTTGASRLRPDSELAGWNPLPRRTQSQRAPRGTNNPDSNRHRAGSASQANAMPPPPPFSENNGGRQRDPSPLPQGDRKGVSLQDQPLTRSTSVKRVASAVKKAVFAPVAKQDGEKRVMILVADGSEEIEVMTIFDVLVRASLRPTIVSLSPQLSPSQSLPYITLSRGARMLADTKFETLKQEHKDDFDAIIIPGGAKGADRLSSSREVQTLIRSFYDQGKLVGMICAGSLAAKTSGIAGGQRITSHPSVKGDLEKHYDYVEDRVVVSGNLVTSRGPGTALEWALTIVNILAGSAKRSEVEGPLMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P811</accession>
    <name>A0A2X0P811_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g03972 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g03972</name>
        <name evidence="2" type="ORF">BQ5605_C006G03972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY55125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P811"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY55125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="62" mass="6292" checksum="3959E3B37582B4C7" modified="2018-09-12" version="1">MRRELRNKKGARAGIGPAAGEIAGALRQSRASKSSPQGGGLACEESTLRSAQDLGARSVPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PA81</accession>
    <name>A0A2X0PA81_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C037g11604 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C037g11604</name>
        <name evidence="3" type="ORF">BQ5605_C037G11604</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000062">
        <property type="protein sequence ID" value="SGY93697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PA81"/>
    <dbReference type="STRING" id="796604.A0A2X0PA81"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098:SF2">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="2">
        <location>
            <begin position="216"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY93697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="387" mass="42613" checksum="14A428847099B626" modified="2018-09-12" version="1">MASVSSSDVAAVAGVPVPDPDPATTTTAQSTTTSSNNATPVSADDQVLVATLGLFILDTFEWRSNTHPAQILRRSDLVIGGGGTYAILGARMWLPPRQLGIIVDRGNDWDCLGEVEKSLAKFGEEMWVWRDQKDVETCKALNLYRGEHRDFKYLTPRIRLDPSVLPPRLRSAHSLHFVCSPSRALEIISQLEPTPTYPVRPLTFYEPIPDRCIPEELDVLKQVLGEIDVFSPNHEEASSFFGISTNEVIDRGLKGIEELAHRFLELGSKSYVVIRSGAWGAYAIQRDHPEQAFWMGPYHGYEKVVGVERGKVKDVTGAGNSFMGGLMSGLAQGKSLRESVRMGIISASFTIEQFGLPSMTLDEGGNELWNGALPADRLKEMRLRSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PAX3</accession>
    <name>A0A2X0PAX3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C004g02806 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C004g02806</name>
        <name evidence="1" type="ORF">BQ5605_C004G02806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY67768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PAX3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY67768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="45" mass="5227" checksum="70CDE9E38193CF93" modified="2018-09-12" version="1">MRFQIDPRRDRHLSVGSEGNKNIWPGIKYVTELEHRPTAPRPVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PDW2</accession>
    <name>A0A2X0PDW2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C020g09200 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C020g09200</name>
        <name evidence="4" type="ORF">BQ5605_C020G09200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000082">
        <property type="protein sequence ID" value="SGZ18707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PDW2"/>
    <dbReference type="STRING" id="796604.A0A2X0PDW2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056840">
        <property type="entry name" value="HEAT_IPO9_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF9">
        <property type="entry name" value="IMPORTIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25018">
        <property type="entry name" value="HEAT_IPO9_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin-9 central HEAT repeats" evidence="3">
        <location>
            <begin position="382"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="968"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1033"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="983"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1041"/>
            <end position="1051"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ18707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1106" mass="120238" checksum="704552012810EBBB" modified="2018-09-12" version="1">MDQLIQVLQGTLSTDPNARLSAELQLSQLTDQSETALALAQITVEHSLDISLRQISPRSLAASIWKYVKEHWSPFFQAFKGPNATTVEVHLFEARGEQSRENADFFLSANGVQIKAQIRQTIYGGLSDPIRKMRLACAVVVSDIAHPDWPDDWPSLMAQLLQLIGPAASPDAVDGGMRVLNDFVGIDMTEDQLLPIAREMLPRLLEIVGTPQTHSPSTRARAILIFRACVMTLFTVKEEHPVAVKAAVTDILPTWLSAFQHLLATDVATELTSSPTWEALAVRTTVFGALEVILNSFPSTLKALLPTFLQFASNDLAALLPLYSTAFLSSTSDFDIPVPVEEDSQVPADLPGYISTVLDFVTQLAGRKSVKALFLDPTTKSGTQLLQSTFETAILYARMTTDDEDDWASDPNAFVADEDDEMVIYNVRAASIDLTSSLIDQFETAAITSLWGAFQSRLHDADAARTNGTDADWWKIYEAALALVGDVSSDLLSHVEDQASQNKRSAFDLEAVFTSIIPNYLGATEFPFLQGRSFVFASQFAPVLPSQLAHQYIDAAIQALDATDAGVPVKVSAVRALTNFFRHLKQNVEPSQAVQSIARLLPLLPQTTENTLVLIVEALVPILKVAAPSLDAPTCSSLIRIVLETWFKKPEDPILGVAIGEVFTSLASTPSPIVTNCLQTDALPTLSNILLEIRTDPYSASAASALELIEAILSGRPSGPEHFGPGLFGTVAASLFEVISSTEDRSVTQSGLNIITTVVRKDVGQLLAWKDTQGRSGLELVLQQVAKLLEPDESESGGLFVGDLVLHLLRKASEQLGPVLPDLLKAFVTRLATAETASFSQSLILPFAYLIHKQADTVLALLEGITVASPTGPRPALQVLLSSWSENVDVFQGSWALKASTLALAELFLSPRPSLSQIVVRGDLLLTDANRNRIMTRARAKNNPDQFSLIPFRAKALKVLLKDAQSALSESGTNGSGRKDYHDDEDEDEDDDAESDDGDDEWADEGQEFASGGLGKDLDYLSDLLGDGSGGLGKYLRGEGSEEGEEDEEDAEGLKDDEVYQLNVATYLKNFFHQAYTNDSNHLKALATEYLKQEEKDILSVLLTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PE00</accession>
    <name>A0A2X0PE00_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C021g09251 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C021g09251</name>
        <name evidence="7" type="ORF">BQ5605_C021G09251</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000083">
        <property type="protein sequence ID" value="SGZ20190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PE00"/>
    <dbReference type="STRING" id="796604.A0A2X0PE00"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43350:SF2">
        <property type="entry name" value="GROES-LIKE ZINC-BINDING ALCOHOL DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43350">
        <property type="entry name" value="NAD-DEPENDENT ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="12"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGZ20190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="426" mass="45053" checksum="EC10B8FC7EBE395C" modified="2018-09-12" version="1">MPTTSKALILSEVNAPFELREVVVDDPRRGEVLVKMIACGVCHSDLSVQSGVLPGQFPSCLGHEGAGMYVTCLSRSSVESVGPDVTGLEKGDSVLLSFNFCSDCRLCHAKKTSQCKAWLPLNFSLARSGEGKPHFAEDSETGEPIAGMFFGQSSFSEYTLAAANSVSRGHTISSDILILHAIGVDAFQCVKIPAFSELALLAPLGCGIQTGSVGYMGFVDSRTFLTSLCPPCRAGSVLNVLKPASDSFVGVWGLGGVGVAAICAAAYLGVKTIIAIDIVPSRLELARECGATHCINGKTEDVEARIKEITGGEMLDFAIEASGVKACMYAAWGLLGSGGKLCQLGVFSQGTEFSLDINVAQVRHLSFVGNVEGASHSPVFIPQLLEMRRAGFLPLEKFTAQYPITEFEAAFKAMKDGSVIKPILCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PEF1</accession>
    <name>A0A2X0PEF1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C008g05339 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C008g05339</name>
        <name evidence="1" type="ORF">BQ5605_C008G05339</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY80255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PEF1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY80255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="173" mass="19543" checksum="D5296933AAD8BA70" modified="2018-09-12" version="1">MEPAKAIDLIGAQPFGDDIIDTSTTGGKLQVLVERAKATLKPLSDVERAVWEGKVMRGFEREAKRKQPENSEKVGFAAEQDNPVAMGFDAESSTLGWRRKLVKGQRSRGTCGIGKLARAWRGAGWRQMAVWRIDWTQRWLARGYYLRLVSFTLSFFFNTHSISISPIRLLQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PGN5</accession>
    <name>A0A2X0PGN5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C035g11382 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C035g11382</name>
        <name evidence="4" type="ORF">BQ5605_C035G11382</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000064">
        <property type="protein sequence ID" value="SGY97094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PGN5"/>
    <dbReference type="STRING" id="796604.A0A2X0PGN5"/>
    <dbReference type="GlyCosmos" id="A0A2X0PGN5">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016790">
        <property type="term" value="F:thiolester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF8">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02089">
        <property type="entry name" value="Palm_thioest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016119855" evidence="3">
        <location>
            <begin position="22"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY97094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="362" mass="39826" checksum="227E38D3745D956F" modified="2018-09-12" version="1">MRIAVYSSLWGLALLPCSSYARPASTSGADGLIKPNTSIPTPIIATELQGHHQLKGVYVHLIGVSEDGAADQRSTFFGNANDQIALVCEQLTQIPELVDTQLNPSGKVEAIGFSQGGQLLRGLVERCSELKFRSLITLGSQHMGISSLPPCPPGSSPFSTCHLFHLSLLKNGLYSSWAQQNLLLAQYVRDEARIEDYLKVNAFLKDVNNEREGDRQVGPPTDGEVIGVRGRDQGEGRNQTYKRNFARLEKLVLLRFSLDTTVVPPHTAHFTLPSPTASPCPIPLDPTCYVDPVEWADLPLYQDDYIGLKELDARGVVWKGICKGAHMEIDRRCWSTVTRFLVGNGEKEGDEDVRQNAFVLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PH18</accession>
    <name>A0A2X0PH18_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C034g11327 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C034g11327</name>
        <name evidence="3" type="ORF">BQ5605_C034G11327</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000065">
        <property type="protein sequence ID" value="SGZ00152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PH18"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ00152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="202" mass="22391" checksum="3446FA7506D1928F" modified="2018-09-12" version="1">MKQTAPVDEHTALLGSAAPPPYHIIDVESNRSSQGPSPSGTPIYYVCTPSGSLPNYALPRVSSSSFSSVHRLPAGPSPFNDLPLPIASALAYQQSLRHADARARGRVIRGVIGALLLWWGLSLLVGLIVENEHELEKWTEHKWRDAKRWSKNHRWEVEPELEGQEKGRWSRPLSDDPLQCVQILSSPQMTTMPTERSEAISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PHI8</accession>
    <name>A0A2X0PHI8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glycerol-3-phosphate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="11">1.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">BQ5605_C035g11451</name>
        <name evidence="15" type="ORF">BQ5605_C035G11451</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 11">
            <text>sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Glycosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.8" evidence="11"/>
    <dbReference type="EMBL" id="FQNC01000064">
        <property type="protein sequence ID" value="SGY98230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PHI8"/>
    <dbReference type="STRING" id="796604.A0A2X0PHI8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020015">
        <property type="term" value="C:glycosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141152">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000001">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(P)+]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000019">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(P)+]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00394">
        <property type="entry name" value="NAD_Glyc3P_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
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        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
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        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)] 2, CHLOROPLASTIC"/>
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    </dbReference>
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        <property type="entry name" value="Glycerol-3-P_dh"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3 9 10" id="KW-0520">NAD</keyword>
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        <location>
            <begin position="7"/>
            <end position="169"/>
        </location>
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            <begin position="189"/>
            <end position="328"/>
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        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
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    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="200"/>
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    </feature>
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        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
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        </ligand>
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    <feature type="binding site" evidence="8">
        <location>
            <begin position="264"/>
            <end position="265"/>
        </location>
        <ligand>
            <name>substrate</name>
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        <location>
            <position position="264"/>
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        <ligand>
            <name>NAD(+)</name>
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        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048683"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00060503"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00084116"/>
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        <source>
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            <dbReference type="RuleBase" id="RU361243"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SGY98230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="369" mass="39641" checksum="B43964290CB822BF" modified="2018-09-12" version="1">MTGPNKKVLVLGSGNFGSCLADHLGDIEHKVFIHCRSQATIDSLNTHRKNPKYLTDHEFSANLTAIGPEPPTTEFLQECDVIVFAIPTQSMRSVLKPLKLESIKNLPLLVFVNKGIEIGTNKLPLEVIEETCGPEVARVSTFLSGPSFAKEIVKRQPTQVSVAALSEEHATRTAELFHQPWFRCYVNPDPIGIELAGALKNVYAIASGVASGLGYESNTRAGLVTRGLAEMTRIGVAYGADPLTFLSLAGVGDLFLTCSSTKSRNFTVGERLGKGENLDHIIETLGSVAEGVDTAKSAYAMVKEKGIDAPILEHVYRCLWEGETAGEMAKRLMSLRMMSEMEGIHETGSAAASPKGTPKSSASGLKLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PJK3</accession>
    <name>A0A2X0PJK3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C020g09125 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C020g09125</name>
        <name evidence="2" type="ORF">BQ5605_C020G09125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000082">
        <property type="protein sequence ID" value="SGZ17509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ17509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="160" mass="17966" checksum="CD06031860A8F073" modified="2018-09-12" version="1">MTSDHYAILVSSRKVPPSSFHPSRALSNTFTPVLWHLLEHLRTGQLDQCSQRLHASCSNRELANEMKPQISELIQRAENGLETMKKRERLLRTRVEKRATLPSQAPLVAPSLGALESQLEALRQKKEALGKQVEGLEQQLANVNKPRGAFGRRIGGQQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PK74</accession>
    <name>A0A2X0PK74_9BASI</name>
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        <submittedName>
            <fullName evidence="19">BQ5605_C029g10728 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">BQ5605_C029g10728</name>
        <name evidence="19" type="ORF">BQ5605_C029G10728</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
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            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
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            <dbReference type="ChEBI" id="CHEBI:173112"/>
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        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
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        </reaction>
    </comment>
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        <property type="protein sequence ID" value="SGZ16095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="F:endonuclease activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
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    </dbReference>
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        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
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        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="13" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="12" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="11" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="18">
        <location>
            <begin position="41"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="343"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1313"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1323"/>
            <end position="1332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="SGZ16095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1352" mass="148809" checksum="9C07D74B8B6304A2" modified="2018-09-12" version="1">MIAAGLLDGFGAGYSDKDVEEFVCNACLGSKGYRLPFPDSELHSPERLGLVHSDVLLFPTPSLTGKRYLVTFLDDHSRKLWAYAIDHKSNVFPTFQTWLADVELETNARLRVLRTDNGGEYRSNAFTEFCKSKGIRRQYSIPYTPQQNGHAERVNLSIVEGVLALLADAHLPATFWDEAAAYFVYCKNRCSHSALAKQTPEFVWNGQVTTATALHPFGCTAWLTVAPDLRSKLDPKAARVIFTGYDLASKAFRFFDHSINKIVLGRNATFLDDDFPGLPVTTPVDVDDTDRQFVIPADTPAPAVKTRTPLVRSAHMDVSSSLDDSAMSAVDVAPGYTGGSLLNSTGTRSSSSPSLSPFSLPATSLAREPSLNNSDDPLDLLSSNTAVHLNLMDVHRSDDDTLEMQAPAVDPVEQPSDDNSPDEIDFLSRHHCAFIATENDDPTLEAIEPVKSITSDPQTWRKAMSSDERDIWAQAAAAEFTAMRDDFKVFTIEPCSALPPGATIVTSKFVWKTKRDARGDVTGRKARLVAQGNRQRNGINFSETFPPVARFCSIRCLLALSAANGYHVHQADIDKAYLHGELDHDIWMTTPRGFDFPSDKVLRLRRSIYGLKQAGRIWNCHIDTSLRNLGYKATGTDHCIYSRIDNQQRPHYIALYVDDLLIVSPGLDEIKRVISGLEQQYGVKRLGPAEYILGIQIRCLDDGSIALSQERYIMDVLARFHFDTTTRGTTVPMTPGLSLTAIPGPGTEHIRSWYLQAIGSLLYISLGTRPNIAFAVSYLSRFANNPGHRHWIAVKHVLRYLRATYRNELLYARGPAKVTGVVGYSDANWGACVDTSISTMCYIFYLAGTAVSWSSKCQTRVADSTTDAEYLALLHAGKEAIYLTQLLSELHVSPIAAAHIFTDNEAAAAVVHDPVCTSGTRHIRLREHFVRDMVNRGNISLSHVGTANMVADVFTKALGPKMFGTHCYAALGLRTQHPRLKSTSRLRGLRRAERAWDLDARREPGPLAQPRGSLAVDLGRAGLLFVQIATLQAQLTALQASQPPAAAAAATPPVTATQANTATASKVVFPKHARLDGPKSFTNWLRQLRLALPNQARGYVLDGVIPLTWTADQLAARDNAAREIIVGSIDSADVSATLNTIPSDDLLAPRIFAALKAHFAPDDATRTLELFARLWDFRKMPASVKAYDTWLREYMSIAQEIRDAKTLLNNVLATHVLAMVPSCLDSFRLTFTDEQRNRRDLPELTTLTDRICIQLRSAGLSSSHSAMLAIASPCPACRAPGHCLRDCTSRAKHPPAGPCRRCHKKGHWALDCKHRGKQKHTGDNNQDDMSLPAAQQPNICDVVTPAQAVVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PL79</accession>
    <name>A0A2X0PL79_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C024g09821 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C024g09821</name>
        <name evidence="2" type="ORF">BQ5605_C024G09821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ26038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PL79"/>
    <dbReference type="STRING" id="796604.A0A2X0PL79"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28139">
        <property type="entry name" value="UPF0768 PROTEIN YBL029C-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28139:SF1">
        <property type="entry name" value="UPF0768 PROTEIN YBL029C-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ26038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="113" mass="12760" checksum="7E7F5F7F0620DA80" modified="2018-09-12" version="1">MDFCICLQIGCSNRLSQEGDGQSRVCPRCHNAAVVQVKSTKCLEICCVPLVPLGSDHLWHCSICQWQIDQSAPPPPLPQQGWAPPQQQQGYAPQEQMQFQQPGYEQQQQHYPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PLZ7</accession>
    <name>A0A2X0PLZ7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C024g09810 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C024g09810</name>
        <name evidence="3" type="ORF">BQ5605_C024G09810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ25972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PLZ7"/>
    <dbReference type="STRING" id="796604.A0A2X0PLZ7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="507"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ25972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="703" mass="79761" checksum="5B4AEDBBE661296E" modified="2018-09-12" version="1">MTSTDEGIFQMPHSLLPETDYLLHSRCCRHDRLNCSVSGEHIPHFEPLPQLDPTWQQPVAAIKDDSLEDRVKKALESFLVEHDLLDRVKGHVEALHRNKLAQGRTICTITPACTATVHDLRIRFFEPLTVALLRRYHGRGLTKEERASRGAEFLGFEPRLGGDAHNQLAAGGITFTMERIRQRRGHPRAKLLSRMVMSFEDDSSFLSFGLKRNLLARGCKFHLYQKDPIPLDLGKKSFGAEGMLNKVSDRLSMILAFLMVSTVERNHQTGQVISPPVRFGMIISTRYVILAEAVVNPTNPKEIGILYSSIFETSHHSHKRVSYPFRFERRSITLMFLADILDYLTEAAAPSPAVIQNLFGATALAETSNRAVRAAKRAWSNDSDHRAERQKKARQSQGSKSSDFPEWVDMWYMEHEVLRPRLSSNVFLGLKSPSPFVLDAVTFEVHPRAELPRRPPSHPPTAAFAGLRPALLAYLSSYLCDRNSSFPGPERSLLNRKDRDPVELPFLDAPQFLARGGFGAVWVARLLRTTSSTKAAGEKDLGWWSVPRLPADAAGHLRGQGQRNSMPTDQPVILKVFYDQIESGIRESLFYEHVFPLLPAKLRAFLPRYYGTYRPDKQRSIVLALGYGGRRLEAADRTTELQEKADAAYRLFYKHGINHGDCEARNILLRDDGSLCLIDWGYATLNFISRQLRWLQTLRFRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PM65</accession>
    <name>A0A2X0PM65_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C024g09880 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C024g09880</name>
        <name evidence="1" type="ORF">BQ5605_C024G09880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ26297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PM65"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ26297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="42" mass="4997" checksum="D2B83D5E86BA947F" modified="2018-09-12" version="1">MQWHGRLNFVPLRIRMHRQNDVIQAGHRLPCQALGNGRRAEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PMB5</accession>
    <name>A0A2X0PMB5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C027g10314 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C027g10314</name>
        <name evidence="2" type="ORF">BQ5605_C027G10314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PMB5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ28332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="122" mass="13523" checksum="C48FD5042E29E4AA" modified="2018-09-12" version="1">MASFGHELYKAIPVANLSPVRPSFLYRHFFIKHRSYGTFSTGNGFSCSYGFKMLLRRRESLGLRAALTGFVTPVNLDRSDRWHSAVDRHASTALQDSHHHPIASHPPAQLVGSHPIDGGARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PPU4</accession>
    <name>A0A2X0PPU4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C066g12820 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C066g12820</name>
        <name evidence="25" type="ORF">BQ5605_C066G12820</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000134">
        <property type="protein sequence ID" value="SGZ35279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PPU4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="454"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="147"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="688"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="689"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGZ35279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1273" mass="141804" checksum="FE306411B2594C75" modified="2018-09-12" version="1">MAIDKFLWKVIILARIPRDIAERVQHLDDNECHESAVRGLSAAPPRSLLSAGNFLGASSYLYDLAPRSLPLASTCFHEFLSLSLGFPATINRASYSYKNNYINPASRPVILAIACCLRLSNLNPDNESLIDAARDLWKERLDCEKKNASTAKPEQPQVPTFTQKSSQRKQCNHWQPRRRAKQRQACPHLATIDRELLRARTLRSLGITIGSCNQAALFVEFEGPGVATSVIRHGHFVTAYGASNNPEDERIDDTELIYDTGATCSISPHRCHFSSYVLALSKAYVKDAGGHLHLIAGSGTVSPQFVLDSGSIKTFDIYNVLHVPTMVATLISGPKLYDRGLHSSCNGKVFRLILDGQTVAICDVRDRMVFRARRISPNVTDSAYALMSHPSSADLFTWHECVGHVGAAALKKMEKEGLARGLRILSGGRSVDSCEACGLGRGAHTSVPKIATTREAVPLRKLFTDVWGPVKYPSLAGHTYLLSIINDASRFHWIFPLKHKSEVTQHIIDFIERVERERDLPVVKIQSDGGGEYVNGVLKAHLAAKGIEHIVTVPYEHHQQAFAYVSNRRSSRANAGGKSPYELYHGRIPDVHRFRVWGCNTTVNLPSHARQSKVSPPGVLCTFVGYSPLGWLFIRHDNGRLIQSSDARFYERSFGRKVVAPTPPIAIDIFEGLDRPDDEPAVAVPVPEEAPEEELDEAHDDDPDDQPRPGYEHVIPTGERTAELANRWGAIPGTRRRPIVDDGDFVELADLLDDDCHRLPLVGHIDLSRCDGGWTPLADVVGDFDTKHIVGDCYELWTGNPDEPTFREAMNGPDREQWCVAYARELSNHEGMGTWDKEESQPPVGRRAITTKVVLLKKCNDRGEVLTFKARLVARGDLQKPGDYGTTYAPTARIASVRILNVLAHVHRWRRRQFDVNNAYLNADVSEQVWIQLPDKTVHRLRRSIYGLKQAGHDWNQTLHGELTKSHGFVRIEEDRGMYRRVREVGGKSLTLLLAMYVDDGIITGDDDIEEFLIAFGARFKLREGRHVPWHENHGRRDAGGASHGSAYSPSGHVMDTSFPYRSVVGELLWLAGCTRPDLSFTVAHLARFMSDPQAEHIARAKHVLRYLKGMASLGLVYHRDLGTEIVPYSDADRAGDKEVMWLRSLLFALGFPCVGPTIIRADSTGAIALSKHPTSHTTTKHISVAYHLSRRLQDDGHVDIRWVETNLMLADIMTKGLGKAKHEHFVEHLGLTAVARQGRCWNGLVQQKTISSSEAKDSWAQYSLESVQLGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PQC1</accession>
    <name>A0A2X0PQC1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C041g11954 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C041g11954</name>
        <name evidence="2" type="ORF">BQ5605_C041G11954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000119">
        <property type="protein sequence ID" value="SGZ33311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PQC1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ33311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="88" mass="9643" checksum="873E2CCCCC405D89" modified="2018-09-12" version="1">MYWKASAAASTSQLLDTPDVPGEKNSPNTNANSALDDFLAMHAGTFSEQMFPSWDFQFDWQLDTSGHSYLAFNGPGNGMMSGDDASRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LQB5</accession>
    <name>A0A2X0LQB5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C010g06040 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C010g06040</name>
        <name evidence="5" type="ORF">BQ5605_C010G06040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LQB5"/>
    <dbReference type="STRING" id="796604.A0A2X0LQB5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.60.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.20">
        <property type="entry name" value="Ribosomal protein S17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00511">
        <property type="entry name" value="Ribosomal_eS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001210">
        <property type="entry name" value="Ribosomal_eS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018273">
        <property type="entry name" value="Ribosomal_eS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036401">
        <property type="entry name" value="Ribosomal_eS17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00833">
        <property type="entry name" value="Ribosomal_S17e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116820">
        <property type="entry name" value="Rps17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00712">
        <property type="entry name" value="RIBOSOMAL_S17E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY14046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="198" mass="22202" checksum="EE403E2C5484D19F" modified="2018-09-12" version="1">MRGGGGIGGDGRGRHPRRNSAPTTRPDPCRHTYHITTRPITFGLRRHPLGLTGRVRTKTVKRASRVVIEKYYPRLTLDFHTNKKICDEVAIIPSKRLRNKIAGFTTHLMKRIQRGPVRGISFKLQEEERERKDNYVPEVSALDNQGAAIDVDPDTKDLLASLGFDSIPVNVVAPSSAFEGRPQRRHVVGAGRPRRDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LUJ0</accession>
    <name>A0A2X0LUJ0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C010g05947 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C010g05947</name>
        <name evidence="1" type="ORF">BQ5605_C010G05947</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LUJ0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY13699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="188" mass="21509" checksum="742737B3D53D6B2C" modified="2018-09-12" version="1">MTPSSFVNASKRHQVFIFPLIFPKGHQKVFNLPEQRWNAWWKALRKVRRVHSDAEDTGHLLSLGSLHPGSQVASPTSPHPNNRSTSCVMCLSEAPECLVHLAVGCPFARRLWSALSPTPHPVFVDFVYPVVSRSERRLVELRVLFFHSIWKLCRRRRFSSDLLEPITETEFEGLRASIQESKGRLVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LV03</accession>
    <name>A0A2X0LV03_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C017g08460 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C017g08460</name>
        <name evidence="1" type="ORF">BQ5605_C017G08460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY20083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LV03"/>
    <dbReference type="STRING" id="796604.A0A2X0LV03"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY20083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="68" mass="7239" checksum="F4FCEA16218915B3" modified="2018-09-12" version="1">MLVQSASEGNKKAEAAEWKAALTDGHVPQVSLERAKGKVESAVGMVTGDIEKQQQGNMRAEKAAWTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LVR6</accession>
    <name>A0A2X0LVR6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">dihydroxy-acid dehydratase</fullName>
            <ecNumber evidence="9">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C013g07351</name>
        <name evidence="14" type="ORF">BQ5605_C013G07351</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:27695"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IlvD/Edd family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="9"/>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LVR6"/>
    <dbReference type="STRING" id="796604.A0A2X0LVR6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009082">
        <property type="term" value="P:branched-chain amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.80:FF:000001">
        <property type="entry name" value="Dihydroxy-acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050165">
        <property type="entry name" value="DHAD_IlvD/Edd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000:SF5">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="12">
        <location>
            <begin position="79"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="13">
        <location>
            <begin position="426"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="13">
        <location>
            <begin position="532"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGY15377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="641" mass="68695" checksum="DEBE7C24B154C794" modified="2018-09-12" version="1">MSEQVVLNKYSRTFTQDDKQGAAKGTSTAFGLATLSIFRKARRERLPWVQSKELTLQPIGIPSAMLYATGMTESQMALPQIGISSIWFQGNPCNDHLRALGDKVQKGCELEGLVGLQHSTVGVSDGQTQGNAGMSYSLPSRDLIADSIEMIVNAQHYDGNISIPGCDKNACREPSFMPGCLMAAARHNKPTLLIYGGTIAAGKRHIDCPSMGGKKGEDITLGDAFESYGAWTTGKITDAEKDDVVKHACPGAGACGGMFTANTMSTVLEVLGMSLPYSASIPAVYPEKQQECLRAAKYMRNLLALDLKPRDIMTKKSFLNAITMCMIIGGSTNSVLHLLAIARSAGIELSTDDFVTIQEKTPVLCDLKPSGAYVMEDLHKVGGISAILKYLLKETDLIDGSQMTVTGMTLAQNVEDAEDLDFEKQDVVRPLSKPVKEKGHLVILKGNLAPNSAVSKITGKEGLRFRGPAICFDDEDSFQESLAKGNVTAGMAVVLRYLGPKGGPGMPESASISFGFRQAMPFHSYPLSRITVLGPTGALMGAGLGGKTCLLTDGRFSGASRGFIIGHITPEAAVGGPIALVHDGDIIAIDAVSREINLEVDDANLAERKKEWKPRPLKHKRGVLYRYARDVKGADQGAYTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LVZ1</accession>
    <name>A0A2X0LVZ1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C012g06893 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C012g06893</name>
        <name evidence="2" type="ORF">BQ5605_C012G06893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LVZ1"/>
    <dbReference type="STRING" id="796604.A0A2X0LVZ1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY16520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="329" mass="35442" checksum="E5DF84F41EE62572" modified="2018-09-12" version="1">MTNATSPILSCHPGSLNAFALKLKTGDSVQSIRARAARKLALHGDGSDIGLQYLWCDVYYTLEDEDDWEVFTDRHANSAEVTVLLTGPSIPTSTPSIASMSSLPPSTSGSQPNDGSSIYSGHSYGRGVVRDVREGTSMHLLSSSASSKAPSVARSAPHNGQDDGDQDTIGGKSKRTAKSIAPSVPEHKVKFEEFHNQLGVRTFIGSIGPVENVRMMMKAGHRACYMSRAFAQQHAFIPKDAAPGFYGFSGITNLGSWPIKVGKKTVEQQVMLVENSYFPVILGRSFMERRGVRTDPLDQTSVVFMDTGEVIPTDLVIVKDAAGHVIPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LW01</accession>
    <name>A0A2X0LW01_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C019g08840 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C019g08840</name>
        <name evidence="1" type="ORF">BQ5605_C019G08840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY22674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LW01"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY22674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="565" mass="62936" checksum="A5DD9B6118557B8D" modified="2018-09-12" version="1">MAPVSLPLFSFRPGLCRLSSVFWPDARTCPQLAGPARLSLSCSSNFLVWSPLVRRSETYHCLSSNFLVWSPLVRRSETYHCLSRCVKQLLGLVSFGPSIRDLPLLEQVCALLNIIETCRVATISDCWQTGFGELSAVLSVLLDVDVYTAGFPSFLSYKCLPSSGITAVSLLTSVFGSSAGRTVQLEEKPIALLSSPAAKRGSVFSRSTAVFHLTRPSLQRESGGPGGSLGFSFVFKMKFVSPSTAKVELDMLEQITQAVDGGMLPPTVAKHLALFELAASLSQYQSQVEDTRLPPPPPAPEEFFQLVWPPPRGLFRRTLELLVLRNPTPLPAPLVDTAQPGEATTLSIRHSLQVFDQRLAVLATLAEYHFHHRDLSVGHILHYQAHLVLVDWSAGIVARLSASESVRLNWNTDPELRPLPRYKLGHVLESTIYCFVNVLSYRIAPQEDIWRFLRHQHQPDEVEHPTDYCHLRGVIWKCSPSEVFFQFEKREELLAAIRSEDAELGDLVDDVTNEWPLWVTDDDGSKALWAAVQAKLYFLSMKRSGTLLLPYGTINQWDPVELTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LWV4</accession>
    <name>A0A2X0LWV4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C018g08733 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C018g08733</name>
        <name evidence="1" type="ORF">BQ5605_C018G08733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY26425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LWV4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY26425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="247" mass="28137" checksum="2028C3D4F737365C" modified="2018-09-12" version="1">MRSVEPSHTLELATWPRREGWQTPRRQGHYNSLAFTALSTFPPVDAIAVLPTRELTGGTRNARSLSGLHCVVDVSLPASMAAFTTCRDRCVPHSQDYLPADEVADREFHLAGRSQLLAARYETLDVARLEPFAVLCTNRATTVFIQCLAFVAKLPIVIRPTIPVYHQEVRTLLRLDQFLAVFPRRLGFHRLRYLFNDSYTNVVLRLAATRTTIPLQLARVVRRVDRALPGFKFLSHKFQLVLFKDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LX05</accession>
    <name>A0A2X0LX05_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C012g06962 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C012g06962</name>
        <name evidence="6" type="ORF">BQ5605_C012G06962</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LX05"/>
    <dbReference type="STRING" id="796604.A0A2X0LX05"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010301">
        <property type="entry name" value="RRP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026">
        <property type="entry name" value="NNP-1 PROTEIN NOVEL NUCLEAR PROTEIN 1 NOP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05997">
        <property type="entry name" value="Nop52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="317"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY16717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="371" mass="41476" checksum="9CEEE86C0F6DD283" modified="2018-09-12" version="1">MSSTTTTKRSSTTTPKSSKGKAALKPSASAPPLGKFLASSEKHIRDKAVASLAKFLSAGHKRTSHDDGEDEPPLIVGDLQWDTNTVIDKRLRDIEMAKLWKGIFFCFWMSDKPLVQQALAQDLANLTLDVRPKDKDAGRVERFRAALAYLRGFWEAVVREWSGLDRLRLDKFYLLIRRFVYAAFALLQREEWDPRAIEEYNQLLTGPGGPLHVTDARIPASLAYHLADIYLAEIERICPPIDSPSPVVPVIPLLQPFLTTLALAPSKTLFQRVTSNVTTPLLEDALPAPPAPPSKRRKVESSIEKPTFPGIFSHAQEAGEDKVSEEERKEKVGKALLRALFEEGAKSATNEVNRRRLYEIVKQREEAGVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LXE0</accession>
    <name>A0A2X0LXE0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C015g07727 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C015g07727</name>
        <name evidence="2" type="ORF">BQ5605_C015G07727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LXE0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015900372" evidence="1">
        <location>
            <begin position="16"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY17262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="70" mass="7616" checksum="355D8E3DB97E7195" modified="2018-09-12" version="1">MRLLALFFFFFLTGAHKLQSFGLAGTATKRAKGGYKATTASSWVKVKPLRAKSAAQIKTRRAPNADSNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LXK7</accession>
    <name>A0A2X0LXK7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C002g01023 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C002g01023</name>
        <name evidence="1" type="ORF">BQ5605_C002G01023</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY29177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LXK7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY29177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="167" mass="18370" checksum="F6EB673637A4B339" modified="2018-09-12" version="1">MFCFPRLSAPTSLFLPTFSFQIEPAGPSTSLSPSRTLQEFPGPRIGLPQRVFQFLQRHHVPLSGVSSELFDIASNAARPEAIPLSLFAPGASNKVKMGQTISFATTKDRSATLQPPAWFLTGSSLYFMCGLTTSLDHPLIRLCHEFDSDAFTRSSSGALYHKFSNRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LY67</accession>
    <name>A0A2X0LY67_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C014g07673 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C014g07673</name>
        <name evidence="3" type="ORF">BQ5605_C014G07673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCP11 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY19530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LY67"/>
    <dbReference type="STRING" id="796604.A0A2X0LY67"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010737">
        <property type="term" value="P:protein kinase A signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008862">
        <property type="entry name" value="Tcp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832:SF11">
        <property type="entry name" value="LD23868P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832">
        <property type="entry name" value="TESTIS-SPECIFIC PROTEIN PBS13 T-COMPLEX 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05794">
        <property type="entry name" value="Tcp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="269"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="349"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="279"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="356"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY19530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="695" mass="75780" checksum="9EF0F81804C4B0C3" modified="2018-09-12" version="1">MDQKTVANPSYAVHGDNTGSHRVDVDGRASAVSPISSSSTSSAVAISRCSASTDHEATHPPISCSSSLVDPSSPSPPSSSATHMVTSWSFQQRCQVRESGLTPRKRSHEHLVEPRSWACESHVKSHAVWEATMALLRPSKHRSRRCGTVPTKKRLHRPASASFKPREGSRETIVSVSHRRTPSGAPCNCQDRETSSIASKRIRTGLLSFGAIQSSSSSAPFSAEARGTGKHGTPNGREARWSDHRRLDWRLPLSYTGSFARALNKVSSDKTVASAPKATRSTGLAATVPSTQPHGAPGPDRPYRRLDSATATRACRSYACLPPRPRSFSAPPIISRPCFPTVHSQSGTMALDASHSHPSSSASSCEASSTSTSLTQVSGSPAPTPENGEIAGAHRLHVKGSAHGRSVGAQTDTNPSIPTSTASFLLPPITMATLKELDLHDILQSAQLRHDIVFDPNLMFRPNYDGERGERKKRAADRYWYAVSRELVLGCRCTAFVGSERLACVCQSPRSDATEISALWPSRIPNLITELRNIVVSLLPVKPSEHSQEEVMEMLDPAFIYQQLTRGLLDVGKLADYLGVTLKMHCAPMRDHMIDNMARICQGDDASVALGLRHCFEILEMMKLDIANHQLRSLRPYLVRTAVEFERNHQQIRLSSEESERVRQWLIKASPEDGSAIRDRVSRSVLQGVLGLAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZ59</accession>
    <name>A0A2X0LZ59_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C002g01573 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C002g01573</name>
        <name evidence="3" type="ORF">BQ5605_C002G01573</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY33960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LZ59"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635:SF196">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="458"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY33960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1001" mass="110115" checksum="495BEF6212DF7B2C" modified="2018-09-12" version="1">MDNNNNTNNASHAAIPPLRPDPPDPPGQAPATTTKSYSAAVGARSAAKHGNATANASTAVAAHPLMHNIENCVIINTPPSTSVEQVLLALDKYYPGLTGAMPCVIKGQRGLRFPKAADLDTLVANGLTVGKNLCKVEKLYSSTRGGVVQCTLTGFFSDPEGLCLFDEQIAAYGTVLRRRIQYIGKTKHISGVYDFILALKDVDVLPPASLSIARDGVTERIPLRITGGMRHCVFLEQDLAAQTEDLSNRAQPDSLSKNARPEFSFNFPCKTATPPAPQPASNQGIAYSLVEKSSESPSSETTSPSPSPPPTTPKSIITRSKSIAALSKPATPEPRAVFAHGAALRSRLDPSLAGPSSIFIRLRKVRASDLIPSLTVNDVVHSDPDSMLGAASDYFERVYEDRPIDDAALKAIIDGLASTRLSPADSLKLEEAYPLEEMTKAQAAFLCAVGLGPKARQWYRATYTNQSASIFLNGWLSATFDILSGVRQGDPLAPSLFVLAIEGFACQIRLRVKGIDIAGLQNVRELLFADDACCALHNLSDLDHLNRAIELYERASASKLSNVKSFLYPLGAFRDRSIAPDLGTWRLSDSQFRYLGIQVGVEIAEDAGWEDVKASTIARIRSIPMYDLPYAAKCSIINIYCYTKILYYSRFLPAPKSVVKEIEEAAMLAIHGRASDGTQRRPKVSRSRLCTPLDHGGFGLIDLPRRLAIDHAKWVFQLRAPDGCFTRHLFDIRIRLQAPNEPTRFTLKTTKLLPARWVRYFEAWALVTTLNPPELSKSQNLEQWATHVLCFPAGHGIQLSVNPTLFRGPDGEVMTPSSFVNASKRHQVFIFPPVFPKGHQKVFDLPEQRWNAWWKALRKVRRVHSDAEDTGHLLSLGSLHPESQVASPTSPHPNNRSTSCVMCLSEAPECLVHLAVGCPFARRLWSALSPTPHPVFVDFVCPVVSRSERRLVELRVLFFHSIWKLCRRRRFSSDLLEPITETEFEGLRASIQESKGRLVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZK8</accession>
    <name>A0A2X0LZK8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BQ5605_C017g08524 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C017g08524</name>
        <name evidence="12" type="ORF">BQ5605_C017G08524</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY20201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LZK8"/>
    <dbReference type="STRING" id="796604.A0A2X0LZK8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF2">
        <property type="entry name" value="CHITIN DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016068026" evidence="10">
        <location>
            <begin position="23"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="11">
        <location>
            <begin position="124"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="359"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY20201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="407" mass="45006" checksum="8DA25140B080DAAC" modified="2018-09-12" version="1">MLLGSSTSLLVGWLAFATAVRGLAIPGYPFHSPFGSSGASKHALITKCKKVGQVRFRLIIVVRARSLTCTSNLPSSQTRPFNRFVRSRVTPLHRSVKTLPILSDSGTSGSIFLVFHRNPTYQPKQFAMKFDDGPDHPGDVIADLFTQHGVKTTFFVISSRNTASRQRSLYNWGCIYDFADEIIRRHKAGHIIASHTWSHVDITKMAPDALAQQLDLVDEALWKIIGVKPKFFRPPYGKHNAASIKAVKARNMTTIMWSFSSEDTVGKTPEQSLKEYGSLMKHFPAPEIALNHEIKEGTAQTVVPHILPRLIAKGYKLVTVDECLGVEPYREVGTPTRGAGCDMDLLDLAASVGPSVLAEGDDPNLVSAEEGTVGINDDPENDQQKKKNGWTRSRTWVASINWKSFDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M045</accession>
    <name>A0A2X0M045_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g01918 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g01918</name>
        <name evidence="2" type="ORF">BQ5605_C003G01918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY37923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M045"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY37923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="274" mass="29346" checksum="5CBCFCB6A877B1F6" modified="2018-09-12" version="1">MKMNNSPSGSTDDLFSLALNSNTASSFGAATAGDAPFSVQQHIDRVSGLLEMTSMVVTLQKMKNNSLPWLPKSKRAEPIYAQLNNARWLSARQARVATDKRGPAAYLELINSHNLGLEETGQSRRFTLAVCRPLFRSSLVYAAGSSSTLLQSSSRASTTRHPAPAAPLPDPAFRRSTSSDARTSRSSPVHANDRNGGGLLTPAARSARGRLSSAQLGLDKFSSHAPSPAEAMHLMPASKEESRKGKGVQRFASGKQAEEEEDWGKSANVDLPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M123</accession>
    <name>A0A2X0M123_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C003g02248</name>
        <name evidence="11" type="ORF">BQ5605_C003G02248</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M123"/>
    <dbReference type="STRING" id="796604.A0A2X0M123"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF1">
        <property type="entry name" value="AMMONIUM TRANSPORTER AMTB-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
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    </feature>
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        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="10">
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            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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            <end position="580"/>
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    </feature>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY39621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="580" mass="62306" checksum="FAB567FDB860B296" modified="2018-09-12" version="1">MANITYGALINAASQVVPVGESYGINAAGTDLIVTGPEYGVAAYSSGTFAAPPLYSRDMLMIPGVGSVVDRGLGPCSLQGYSARGSLFGARTALLRSEGIALHGFTDVFAPLVRNYRPTATCTPGTLCRRKNALTVLSLTMLCMGIVSFQWFFWGYSLAFSPTGGPFLGDLHFFVLRNVAEQPVPQANNKVPQIVYMIYQNMFAALVPAVFIGAAAERGRVLPACIFFFCWSTVVYCPVAHWIWAPEGWAFKLGVLDYAGGGPIEICSGVTGLVYSIFLGKRRGFGTPLLAFKPHNVSYVIQGTIFLWVGWLGFNGGSTFAANFKAAFAIVNTNLAASFGGLAWMLIDYRLERKWSVVGFCTGAICGLVAITPAAGYVGPAASVFIGVIAASISNLLTTLKGIFNFDDAMDIYACHGVAGIVGLVFTGVFAEPSYTGNDGYSTASGWIKHNYIQVGYQLGYICAVWGYTFVVCFALMFLINLIPGCKFRVDENQEIVGTDDAELGEWAYDYVVKRRDIEAPDELRDYHSQSMVQRPLAEIARVSGNSSSLDTAIPPASEMTASNALEKSAPAGKTEEVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M188</accession>
    <name>A0A2X0M188_9BASI</name>
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        <submittedName>
            <fullName evidence="6">BQ5605_C084g12999 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C084g12999</name>
        <name evidence="6" type="ORF">BQ5605_C084G12999</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000039">
        <property type="protein sequence ID" value="SGY28644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:intracellular protein localization"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
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        <property type="entry name" value="Polarity_Bud-Selection_Reg"/>
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    <dbReference type="PANTHER" id="PTHR47775">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 14"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR47775:SF1">
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    </dbReference>
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            <end position="225"/>
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            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY28644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M192</accession>
    <name>A0A2X0M192_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C087g13023 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">BQ5605_C089g13039 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">BQ5605_C120g13286 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C087g13023</name>
        <name evidence="2" type="synonym">BQ5605_C089g13039</name>
        <name evidence="1" type="synonym">BQ5605_C120g13286</name>
        <name evidence="3" type="ORF">BQ5605_C087G13023</name>
        <name evidence="2" type="ORF">BQ5605_C089G13039</name>
        <name evidence="1" type="ORF">BQ5605_C120G13286</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000028">
        <property type="protein sequence ID" value="SGY27762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000032">
        <property type="protein sequence ID" value="SGY28068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000038">
        <property type="protein sequence ID" value="SGY28544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M192"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY27762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY28068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY28544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="144" mass="16521" checksum="E5E181C5D3B251DF" modified="2018-09-12" version="1">MSPSQKKKKLLFCGNDAAVIETVSHYFFECAYSTSFWGGVLRILFDKLGIEDTDVDPSTFTPEQLTMGLPLLRGRGRTTSRWMWVRLACAIGFQRLHLLRWRVHQRFELDKVVAPPSLPSALRAFERDFLSRAGFVPGARDWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M211</accession>
    <name>A0A2X0M211_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">D-aminoacyl-tRNA deacylase</fullName>
            <ecNumber evidence="2 6">3.1.1.96</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C002g01211</name>
        <name evidence="8" type="ORF">BQ5605_C002G01211</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a D-aminoacyl-tRNA + H2O = a tRNA + a D-alpha-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>glycyl-tRNA(Ala) + H2O = tRNA(Ala) + glycine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the DTD family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="2 6"/>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY31121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M211"/>
    <dbReference type="STRING" id="796604.A0A2X0M211"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051500">
        <property type="term" value="F:D-tyrosyl-tRNA(Tyr) deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106026">
        <property type="term" value="F:Gly-tRNA(Ala) deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00563">
        <property type="entry name" value="Dtyr_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.80.10:FF:000001">
        <property type="entry name" value="D-aminoacyl-tRNA deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="entry name" value="D-tyrosyl-tRNA(Tyr) deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00518">
        <property type="entry name" value="Deacylase_Dtd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00256">
        <property type="entry name" value="D-aminoacyl-tRNA deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472:SF5">
        <property type="entry name" value="D-AMINOACYL-TRNA DEACYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="D-TYROSYL-TRNA TYR DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="DTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="169"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY31121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="217" mass="24207" checksum="7DFF11CDE7637321" modified="2018-09-12" version="1">MKAVVQRCRSASVTVDGQVISSIQRGLMVLVGIGTNDTIHESQWLVNKLLNLRFFPEGDNDEWGWKKSIMDIGGEILSVSQFTLMAITKKGSKPDFHGAMAASKSKAMYDTFLTDLRTKYQHEKIKDGQFGAMMDVQLINDGPATIILDSIDAPDPVIPKPYLTPEQKRLRKEQLAKEEAEKKAAAHDRKPLSTTEAAPTTDESLAQKFKESMMETY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M4N5</accession>
    <name>A0A2X0M4N5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C003g02002 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C003g02002</name>
        <name evidence="3" type="ORF">BQ5605_C003G02002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY38337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M4N5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="126"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="195"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY38337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="576" mass="64121" checksum="0D821548D4518E71" modified="2018-09-12" version="1">MDPTSKPQAPPDPLDAQPPDFSTYREPASAEESPDELDLIGHHSRDESPDEIDFLARHHRAFIATDDDNPEAEAIQPVKSITSDPQTWREAMSSDKREVWAKAATAEFNSMRDDFKVFTIDDRSTVPAGTTVVTSKFVWKTKRNALGEITGHKARLVAQGNRQRDGIDFTDTFAPVARFSSIRSLLALAATNGLHAGRIWNRHIDASLRDLGYTATGTDHCVYSRLDDRQHPHYIALYVDDLLMISPDLAEIERVILGLEQRYSVKRLGLAEYILGIQIRRLDDGSVALSQERYIMDVLARFHFDTTTRGTTVPMTPGLSLTAVPGQATERIRSWYLQAIGSLLYISLGTRPDIAFAVSYLARFANNPGHRHWIAVKHILRYLRATYRNELVYTRGQARITGVVGYSDANWGACVDTSISTMGYVFYIAGSPVSWSSKRQSRVADSTTDAEYLALSHAGKEGIYLSQLLEELHVQPVAPAHIFTDNEAAAAVARDPVRVSGTRHIRLREHFVRDMVNRGDISLSHVGTSDMVADIFTKALGPKVFSTHCYALGLRTRHPRLGSASHSRASVVARTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M5K0</accession>
    <name>A0A2X0M5K0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C001g00009 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C001g00009</name>
        <name evidence="1" type="ORF">BQ5605_C001G00009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY43286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M5K0"/>
    <dbReference type="STRING" id="796604.A0A2X0M5K0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.10">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, srp9/1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009018">
        <property type="entry name" value="Signal_recog_particle_SRP9/14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54762">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, SRP9/14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY43286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="95" mass="10496" checksum="9396A210A2D5F445" modified="2018-09-12" version="1">MGHVHAGLTPSLRGISRRGKYTIRWGHDLGMLVLKVTDDLHCIKFKARSGAFINRFEAFNVAMQTSMHRSEFSALDQIVPEAAHHAPAGVDPKGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M636</accession>
    <name>A0A2X0M636_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g04139 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g04139</name>
        <name evidence="2" type="ORF">BQ5605_C006G04139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY56495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M636"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016182046" evidence="1">
        <location>
            <begin position="17"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY56495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="69" mass="7609" checksum="C86A99C7A7EA7FE7" modified="2018-09-12" version="1">MILRLVHFLWLQLASSYKNNCINPASRPVILAIACCLRLSNLNLDTQIHHTAFGPAGAFEGEARGLFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M649</accession>
    <name>A0A2X0M649_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C001g00209 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C001g00209</name>
        <name evidence="1" type="ORF">BQ5605_C001G00209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY44853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M649"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY44853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="54" mass="6098" checksum="0B6C25520C1B8724" modified="2018-09-12" version="1">MCIARLVVIQNLCVLTAPPVSLPHPRILTCVDMCKDTPARARDMRKDTLARKEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M6Y0</accession>
    <name>A0A2X0M6Y0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C007g04447 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C007g04447</name>
        <name evidence="2" type="ORF">BQ5605_C007G04447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY60548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M6Y0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY60548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="181" mass="20206" checksum="05687B30E57C2A0E" modified="2018-09-12" version="1">MKAPNILNPRDSKANSFANKLQRYADSLAEDAATVRHAGRYKRNGGFDHQAASWFLFDMVTSKWKRYSGIRTAGQNTLSDHTIQAVCSEVVDDPANKLSFASRRTQDAVQEMSYNSGKARKKKKKKKKKKKKKTKTNKELCSSAGEETMSVRAVTTSEKETVRRAAASPTTGEIIRSTTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M706</accession>
    <name>A0A2X0M706_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">BQ5605_C001g00539</name>
        <name evidence="18" type="ORF">BQ5605_C001G00539</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the U5 snRNP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY47519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M706"/>
    <dbReference type="STRING" id="796604.A0A2X0M706"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17945">
        <property type="entry name" value="DEADc_DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000322">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="457"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="488"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="713"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="56"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="333"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="864"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="457"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="208"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="224"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="SGY47519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="894" mass="98082" checksum="BB2D001F725D71C3" modified="2018-09-12" version="1">MSSSSNGNGSTRTPISIEALLAKQRQEKEEQSRPKFLTKQERAAIALAERAAQVEAAKEQQLQLQLKQNQLERSTPSNHSQPQQRSYGGSGQGRYDDRAFDSRAGRNGALDYNGQSSSSARGAYANHSRNARARSGLGFQPSRPDDHTPTGPRGNHDRRFDTRGGPPPPSAPRADRERDAYSQRNGDDRMQLDGAGSKGEMPPPSARPSATDNAVPSTTTTAAKSEEPSIKEEQQEPKPIQQDTPAPVAPKRKLTLAEMAAEQGVNAAAAAAIPLDDKLNATRYLGANHLEKRKVSHGTKLYADPEADGSFYRIQKTKISTKKFDFDWDQTDDTASNEVDPIYKPYIPPTVSKPSPYERRNPNHGGTNRTEAPGIAAPPHPVQALVPRLFGRGHLGGFDRDLDRAPSGGSGKRLKGSIDDRHWTGKSLDEMRDRDWRIFREDFSIAARGGHIPLPLRSWEESSIPRPILDAIEEIGYKEPSPIQRQAIPIGLLNRDQIGIAETGSGKTAAFVVPMLAYISRLPPFTDENRSQGPYALVLAPTRELAQQIESETNKFCKLLGYKCVSIVGGKEIEAQALSLREGAEIVIATPGRLKDCIERSVLVLSQCTYVVMDEADRMVSLGFEDVLNFILDALPVSNLKPDSEEAEDGEKMSSMIIAPVEGSTTTESTLALYRQTVMFSATMPPAVERLAKKYLRRPAIVTIGVAGQAVDTVDQRVEFITVEDKKKARLLEILNHGGFEPPMIVFVNQKKAADVVMKDLVRARWNATTLHSGKNQEQREAALNSIRNGENDVLVATDLAGRGIDVPDVSLVVNFQMSNTIEAYIHRIGRTGRAGKTGTAITFLADHDEDLMYDLKQEITKSPVSRCPPELARHPAAQSRQAGKRRGAQDIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M7J1</accession>
    <name>A0A2X0M7J1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C007g04657 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C007g04657</name>
        <name evidence="3" type="ORF">BQ5605_C007G04657</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY62133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M7J1"/>
    <dbReference type="STRING" id="796604.A0A2X0M7J1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090173">
        <property type="term" value="P:regulation of synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039057">
        <property type="entry name" value="Spo22/ZIP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013940">
        <property type="entry name" value="Spo22/ZIP4/TEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40375">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40375:SF2">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08631">
        <property type="entry name" value="SPO22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY62133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1047" mass="116280" checksum="9D7FAC83501D335E" modified="2018-09-12" version="1">MGPSKTKKARTDHDRPDKIEQWLHACADTAPELDELNRLVRHFAGTAAGVGSLGRDHDVRQQSNDERGVRSLQSSQALSDVLGQKLEQAECLLQTLQLRLAPAQQRARDVNSEGDTRPEAQTERGTLASWQDRIDAIGVMLWNKVTEMKTMTASGTQYTPKISPRIALQIKPDVSSDSLPLQWLSMIARARHLAYLLIQLGTPEPISSEGRSARRVLLLSLLNKIIAESLFTKGEQIQLSRLFDAAATYAQEIHVPAVAPPSRPDTTPDDVRALSGHYIQRIVFESRRSAFGVADFIKHRLESLIPSSRCLYQQVEKIAHGALDSAREVLAIENSSSAALQDKAKEWLLWSIELAEGMRSESARAIKIASLSLLTQIHTRTQSWREAEEVVAQMLTIEATPAMWLRMIRLMLERDAGEGELGQAFGQATTAIVTWCNEGDLEKNSVRLSAAAQRYHDTHHRPDFAMFKKIVTNLRSPADEATSRIIRQIAMTVTVHSRSADQTLVTSLFQDISTHLGEAFTLSADSAFVATTYFWRHGDHERAKGAFFEAAEWYRLSLHPLLKEIGGVVEAKSMRKAVLCYLEIRDFVRAEQTMNLRPDRPPDARDCFIRYFHATLRQDVDQAKQALDKMIKAPDFRYALLLWASKVANESGITALSTAVLQALLDVYRRGEGESTQNEMLTTVRYVGLIRLLASRLASEPDSGLWNTANLRLSLARLITSEFVAAADIVRESFGKDLSTVDKDITWLLKTGYNLCATYSSRWPAQVITPMYEAVARLGDLKLESGSVEDPKLKRSIVFCRVATLSGLLAQARSATSASDQSKLYSKLLRDTQEIAQSVPSLSEKSDDVATSALLAFEVEARSGLGDWGNVEALFSRLTSAKEPTVSLSAIKLITAQAIGSDDCAPDVLGSILEKTLHTLFYRKDLDSTTLGAWLRVMISSLLASAPGQALTYVKHALTFVKTLLITDNSSQTGYPCDEVQWLVATTWDRGLDLFSVRDLEPAEEWCQLAVELAQCIDENQTAMLSRSLEQLRMRMRAFASTDSDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M820</accession>
    <name>A0A2X0M820_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C001g00657 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C001g00657</name>
        <name evidence="4" type="ORF">BQ5605_C001G00657</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY48510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M820"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056146">
        <property type="entry name" value="DUF7729"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39460:SF1">
        <property type="entry name" value="C6 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39460">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24855">
        <property type="entry name" value="DUF7729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7729" evidence="3">
        <location>
            <begin position="266"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY48510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="508" mass="52908" checksum="72A3A610F6B903FE" modified="2018-09-12" version="1">MRQDITRMVVNAIAGPSRPRVDPDLPTAQPATVDRQAAHRQRRRGGASMPPSSAVSISGTEPQARPVPRGLSSRCRRCLVTLVALSFSTSLVVACAAVLPVRGLAHASGILPRALIVRKPDPDAEGFALPHRPIGVDRPKGSPPPGTSASEQYPPVPNKLAIFAPAKSMVDLRHLYKSISAASSCVTRSCDGALAPAQVLVPRAGESSTSTPTAAPAVTTNNPSASSTALLATTSAASASTSTSTPSSTTFAAVSTSTSVPSNYTLPQAFDATLGTNFTSTACPSFFRTFLANPAFIACTPFSLLMSTSNGFFMAARSPFALLPTVLDAACAAPVATCTTLMNQLAGQLAKARNCGNDLSRRNPLVLEALEGFQNYAMMYQAGCQRNNVTAQYCFAEANVATDPSAQYYYYLPEGTFLPSGTVPECGSCTQGLMNIYAQYARNSTYVISQTYGGARTQTALACGPSFAPLIAVASTSAAAPHVSSASASVSPLLLFVVLMTSLYPVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M9W7</accession>
    <name>A0A2X0M9W7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Calcineurin subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Calcineurin regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Protein phosphatase 2B regulatory subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C004g03120</name>
        <name evidence="10" type="ORF">BQ5605_C004G03120</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="5">Composed of a catalytic subunit (A) and a regulatory subunit (B).</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the calcineurin regulatory subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY70204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M9W7"/>
    <dbReference type="STRING" id="796604.A0A2X0M9W7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45942">
        <property type="entry name" value="PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="21"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="90"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="127"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY70204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="169" mass="19185" checksum="75BB9324B2FCD02B" modified="2018-09-12" version="1">MGAGQSQLLEEMEKNSNFSAPEIQRLKKRFMKLDKDGSGSIDKDEFLQIPQIANNPLASRMIAIFDEDGGGTVDFQEFVAGLSAFSSRGEREEKLKFAFKVYDMDRDGYISNGELFLVLKMMDQQLQQIVDKTIMEADRKGVGKLDFEDFKAMVANTDIAKQMTLEDMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MAA3</accession>
    <name>A0A2X0MAA3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C005g03305 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C005g03305</name>
        <name evidence="3" type="ORF">BQ5605_C005G03305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY73567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MAA3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="44"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="607"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY73567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="697" mass="78060" checksum="472FF30672152241" modified="2018-09-12" version="1">MSSKPQVVKIEDVGAISSADVEAIRIARLQALVHLESHEGRNGRFFGSRLPVELLCRIAYELDEQNLVNMTHVSKNWRKALLAEPKLWWRLEELAINHDESIGRVSRFAQRSKGELRFLELEFDNMCECESDLPAIGVLRLCLQEIVRHDGARKLDAIEVNMRGYEEEGDVDGAFECLAMVLQVCELCLVFTSLVSLAKKNRLFSFPSPTRQFCQFAAINLKHFYVDTPFERFPSGAPFFAMLPKVQHLFISTAALELPGDISLPDVFSATYSGRRKANVCKHLEIMSLYGCLLMDTHFPDMPALRVIDLLGVRCDNLYELLSKAAWSLQDLRLATVDTKAPARFIDPEATNNEDADLTPVLQLPRLLHLRYRCERKTPSLWTSPTNAMALPFNVETAALKTLSFNTSHWADIDYDQTYIDDVLSTRNLEKQELINIFRQAPMLEALDLGRVLRAPGPSLLTDALSATGGVSALTHLIINAGLSDKNLETLHSLAPNLRYLDAREAGVTFPALARFANRLRNGSSARLRTWLDKRFRLIIVASKPVQEPKLSQLCLDLRNLLVTLSGTQVAHLATQLVLNSPPNGPTFPTVKAEIFSLASCPTTRSSSAIMDESPSSLGNHGGKKPGKNATRSAAPSLINESARRALTTWQVRREQDLALEWFESSRLDLVWEPPEEFKTFKWDLGPARVDPYALSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MAH9</accession>
    <name>A0A2X0MAH9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g04233 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g04233</name>
        <name evidence="1" type="ORF">BQ5605_C006G04233</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY57178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MAH9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY57178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="85" mass="10069" checksum="7A2A931ED3C1BDBF" modified="2018-09-12" version="1">MIVFLTSCEERTVVHVFPMIGRKWNARPESVWYTEETVRKRCWMNADNMSSLERSLIEFWVQAQGWRLRRVVDEDHPAGASAELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MB54</accession>
    <name>A0A2X0MB54_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C007g04434 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C007g04434</name>
        <name evidence="1" type="ORF">BQ5605_C007G04434</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY60457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MB54"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY60457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="217" mass="23804" checksum="B72A69B60845A6B8" modified="2018-09-12" version="1">MVASVATAKLSFPLSAIPGEFQEFDLKCRSWADGHVLLVRAAPVLAFNATLVTSGKAKSPITDLAKIEAAKVVYERDCFSESAAQNTRIYRVGSEQSASCPLAGHEHSGDLPKEPIRGGGPRSAKLLAARCSQCQQDITDRREFGLMIPAPASGWRIHFRAHIMRSRRLNHAAQPKRCALSAPSIEPSHHQWSRYNLHNPGLLSLRIDSDPSFSRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MB75</accession>
    <name>A0A2X0MB75_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C007g04455 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C007g04455</name>
        <name evidence="3" type="ORF">BQ5605_C007G04455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY60606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MB75"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015855364" evidence="2">
        <location>
            <begin position="20"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY60606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="106" mass="12046" checksum="1D8BD97686CF886D" modified="2018-09-12" version="1">MVRFGLVALTCAFATLAAAKNDPEKNKHHDLTPPQEEQDGTPERCFARSLKDVMNSWELCPEHAESPKLNVSRFLKCACTNENPYGNGTYVDKYFNWLTSRASHRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MBA4</accession>
    <name>A0A2X0MBA4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C007g04485 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C007g04485</name>
        <name evidence="2" type="ORF">BQ5605_C007G04485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY60787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MBA4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY60787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="97" mass="10609" checksum="D0BD4E6F37737073" modified="2018-09-12" version="1">MKKVPKSIEEVHPTTRTVRNDDVGSLDEEVRSEAWERKKALRPKQDTTAAMALPLLCGEKALLVPLTALDKPAEEPSPVANSARASPVTPEEAKRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-11-27" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MCJ7</accession>
    <name>A0A2X0MCJ7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GPI ethanolamine phosphate transferase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C008g05153</name>
        <name evidence="14" type="ORF">BQ5605_C008G05153</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MCJ7"/>
    <dbReference type="STRING" id="796604.A0A2X0MCJ7"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051267">
        <property type="term" value="F:CP2 mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16024">
        <property type="entry name" value="GPI_EPT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037674">
        <property type="entry name" value="PIG-G_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039527">
        <property type="entry name" value="PIGG/GPI7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045687">
        <property type="entry name" value="PIGG/GPI7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23072:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23072">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19316">
        <property type="entry name" value="PIGO_PIGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 12" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="523"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="572"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="614"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="654"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="736"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 2 C-terminal" evidence="13">
        <location>
            <begin position="491"/>
            <end position="895"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF19316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGY79513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="897" mass="97780" checksum="8192339A4CE65E32" modified="2018-09-12" version="1">MSRDRSTWVMLSLLSLAGALLFARGFFPVKPLLDGYSTPYGHTNQYQPSIIAHGAQPKDGSDAYVPFDRLAFILVDALRRSVGGRVYRMRATPNLAYSVVTFDTRSDFAFGPTSQMSFVHSLIDDNRAVPFTALAQAPTVTLPRLKALTTGSNPTFLDAIMNLAEGTAPVLQNVDSWVRQLALGDEAVGRNPKKVVFAGDDTWLRMFPEEWFSWAEGVSSFFVSVSPKEHCSQVSDLRHMIDQESALLQDTVTVDTNVTRHLDALLSRTSSSTKSPPADWDVLLLHYLGLDHVGHLGGPNSPLMHPKQVEMDKVVERIFKTLEERDRADEKHSLLVLVGDHGMNEIGNHGGSSEPETTAALLIASPTRSMRQHSDRPVESRAENPYRLYEVVKQIDLVPTLSVLFDLGVPTNSMGKLIESVVAAYGPKNMPSCLGRNARQLERVLDAASPGASAGVASQIVGSDRLSLEGDVREFILRAQDRLMSTFAESDLRPMVFGLILQASTAAQALLRTRRTLDGSSSSTGRFLVAATLLVYLGTYFATSFIEEEHEFCFFGAASSLLLLASRPKALLHVRVMLLVAAISVRLMRGWSFNGQKSVPNESLTALLAASPPAFSHLLSGFSLLFGAAIPLYSLVCAAKPIPHLSRRMPLSTLLLRALSFGTLATLSLLHAAVNLILKLFSASASSTLSDLGLGDPVELSRISFGLGAATWLMARICQSAGSSDARTYKVLQLSAIASTLMTVSRPANLFLFPILWLQYFLLSNLNFGPVISSFLILLLQRVAFFAFGGSNSLATIDLSNAYTGLRSYSVLPVSLLTYASNFAGPIFFSTSSLLPHSTLPYTTTFHSLSLLALCASATHFRQHLFTWTVFSPAVCYQIVWSSFGHLLTNVFLQALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MCY9</accession>
    <name>A0A2X0MCY9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C004g02797 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C004g02797</name>
        <name evidence="4" type="ORF">BQ5605_C004G02797</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY67680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MCY9"/>
    <dbReference type="STRING" id="796604.A0A2X0MCY9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000006">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.790:FF:000002">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000009">
        <property type="entry name" value="Ribosomal protein L10a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_uL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY67680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="218" mass="24386" checksum="FAC70F4E2B808EB1" modified="2018-09-12" version="1">MSSKISVSSVRGSIKALIEESTGEKKRNFVETVELQIGLKNYDPQRDKRFSGTLQLPHTPRPRMSICILADAADIDRAKLIELEYMSVDDLKKLNKNKKLVKKLAKKYDAFLASEALIKQIPRLLGPGLSKASKFPTPISPAEDLGKKVTDVRSTIRFQLKKVLCLGTAVGHLEMPDDQLVANTMLAINFLISLLKKNWQNVKSLTLKSSMGKPHRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MD69</accession>
    <name>A0A2X0MD69_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">BQ5605_C004g03149 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">BQ5605_C004g03149</name>
        <name evidence="18" type="ORF">BQ5605_C004G03149</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY70419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="17">
        <location>
            <begin position="349"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="631"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="685"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="709"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="SGY70419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1303" mass="143053" checksum="1EBDA394D31ECB9C" modified="2018-09-12" version="1">MSDAGASAPEAKLREPTPDAPPLRPPTHSAAFATTELLRNSSGYRDWVLAIRSRLPSGVVRYLNTGVPLESWPASYVPLWDHYACSSICASVDSQTVLPGLSPYLDESLAAPKVWQALRERYGTVSAVDLLPVIQRLFSSDPVPVTPDLFLQFRDSFENDARLLQDSQVTVNALLASHLLARLPSSFDAWRTTFVADQGDSTAMPSATEIFTRLYRDVKACPVDTPVAAVATPQARHGCSRPCPNPSCRKLHWLRECPDTAWAAAYRARRTAEKKASQPVASPTPCTPKALLAVPANVSLLTLHRRLAHLPVAQIKNIVQSGLVTGVDWVYKDQELRDFYCNACLASKAHALPFARSKSIASGRLDLLHVDVAQMPRPTFGGHRYMLVIIDDFSRKHWCILLALKSDVFPRLRDWILEVENATGNKVKTIRSDNGGEFTLRNFVDFCASKGIRRELTIPYTPQQNGRVERSNRTIKEGILALLYSSGADSRLWGEAALYYVHCKNLMPHAGIGGEIPDTRWHGFAPDISTLRAFGCRAWHHLPSAKRTDLDPKAVPLLFVGFDQHAKAFRLFEPSTRRIQLSRNVVFRESEFPALRPAPDVRAEPIPLPVPVDAYPDQVDPLEPSLVASPRSLAPRAEPPRPVPAAPDQGPHRPAPAREVPDQDSLAPPAPDQGSPALELPDPESPASSASDQGSSDSAISTPCPSPRPVASRALLAPPSPARSDSPDPIDLLPRPRDVASLCQAQEFPDDVDDALHSPSAVAYLASGAAALIETSPADPAELIAPARDPPHWRAAMATPQADEWRLAARDEFDSLLRDFSAFTPIDESLVPADAKVLGSRFVFRTKRDQHGQVKSYKGRLVARGDSQRSGIDFDETFAPVAKFTSIRALLALAAAHGYHVHQADIDKAYLHGKLDAPLYIRVPDGIYMPGKVLQLHRSLYGLRQAGRIWNDEIDSALSALGYVATESDHCVYVRTTGDVHHYVALYVDDLLMISPSLPEIERTLQGLEQRYGVKRLGEAEYVLGIQIRRSPDGSISLSQEQYLKDVLARFGMSDAHPVATPMQPDLRLEVELQPTPFPDRTRYLQAIGSLMYASTGTRPDLAYTVGYLARFSHSPSAAAWGAVKHAFRYLAGTLSHGLRYARGNPAPLLGYSDCNWGACVLSSKSTMGYTFVYAGAAVSWSSRLQSRVADSTCDAEYLALSHAGKEAIFLRQLFGELGLSSSKPVLIYGDNQGANALTKNPVFHARTRHIRLREHFVRDMVSMGDIVVQYINTGEMTADIFTKALSRDLFARHRGRLGICAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MDG5</accession>
    <name>A0A2X0MDG5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C009g05454 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C009g05454</name>
        <name evidence="1" type="ORF">BQ5605_C009G05454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY81084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MDG5"/>
    <dbReference type="STRING" id="796604.A0A2X0MDG5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY81084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="515" mass="56442" checksum="7498B49333159F7F" modified="2018-09-12" version="1">MPFQLTHVDHVLAGISPNAWLYESNCRSIDGLAERVLHRITLYFASRISDEIANRIADHIAEGPPTGALAASGSLIHRSTPLGPAHMDWSPLKDFFLSPISSGDGLAAAAADLGQPQNESAMNQMAPEITWHLGDPNLVSISSKAMLLLLLFGVLDLPTIWIGQEPLGRLVKTPLDQDREVYDRNEFPDFIVLSRQAFDANPELASAWAQDHLDDGQNGVLDWEQVAAVGVLGGMKKSDDTSEYECVFPARRLKHHLRMLAAESPIRSHTFGFTLDSSILTLYLHTPSGLFYSSDIECTEANGHLSTFIERLLSLNDIDLGKIASPGGPDGPPLPFPTAVLPPQVPSFARHLAKVPTMGSIEIEKTVFRSGEVLGLQKSASRVRAIRDGPGDNREYAMTVSFVEEARCNEHDQIRQMIASASPHEREGLTNFVDVHRQHFSLVPHFLKGDLDAEKCAEICGLKPRAMEVTFQEHCFEPIWAVDSIEALTRAVLGAVKGSLRSRLGQGYPTPGETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MGD6</accession>
    <name>A0A2X0MGD6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C017g08419 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C017g08419</name>
        <name evidence="1" type="ORF">BQ5605_C017G08419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY19983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MGD6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY19983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="56" mass="6644" checksum="F2E4AA90FB7D16CA" modified="2018-09-12" version="1">MSRIDKGVHIFYRRYPVLAPSLGRYDEKWVVTYHCEEFDRSPNVIEMRIAEVIGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHD9</accession>
    <name>A0A2X0MHD9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C096g13096 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C096g13096</name>
        <name evidence="2" type="ORF">BQ5605_C096G13096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000010">
        <property type="protein sequence ID" value="SGY11646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHD9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY11646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="218" mass="24665" checksum="2A41A66F744B2617" modified="2018-09-12" version="1">MAPRATEGERAWLDIDSHLIRDESGQWRVRCELCNKHYKLPGGTGQTKPDQECQRPLPEDEIRTDEDQEGSDRLLRWIQKVYRPFLGKRVPDEYWDQLESEHRTRQAALRPFATTVLVHVPEPPKPPTDGDLEPERKKIWDSWIRDAYRWMRKKGYGGEGAASTSGAREEDAISEHSSATGQHSDHGSAAGSEAESNLSTLSELTSLSELERGLDTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHG3</accession>
    <name>A0A2X0MHG3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C008g05331 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C008g05331</name>
        <name evidence="8" type="ORF">BQ5605_C008G05331</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY80222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019783">
        <property type="term" value="F:ubiquitin-like protein peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="7">
        <location>
            <begin position="891"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="1181"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="16"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="62"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="945"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="994"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1071"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1461"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1602"/>
            <end position="1632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="948"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="999"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1472"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1506"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1602"/>
            <end position="1616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY80222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1700" mass="191211" checksum="694A85D0262F4E32" modified="2018-09-12" version="1">MAPVALIMSTGEMSQLLQNKGGRPPIALQEQSSPEGYASEVDSEVDEDEDSLQVLAALVPVPSKSSISSPSAVSGLLISPKSRSRDSDEDSADEGYYGVDDDNSDENLIDNIFSALLLARNDKKILDRHTYEPSRQDKELSNTTREAIFSNMILTTAEHNELRLRPLVLNCRKPRSGWEFVRKLPVLELPKFMATEKHDWAPRKYERCLAVVERPYGDAPSSTDHQHPSEVAVGIEWRPEVPITLREAWSQPGEGRPVAEVLRITHRCSGACKRVRVKDGKLVHKKRDNDKDPGKTCSTQLKILVQADDLSSALVYTLGNHEGRQPPPNVRRPAPFIRALAHQEVFRQANTPTLAFQSECVLQVCTRSFHFSRLTISSFLDDGLDHFTDMNQRMSFWEKQNETILPQYRKVGAKQLRNMFRAKGRQNAQHGSSLYSLARTAELRPFTLQNATEPETRGVAYFQPFNEKTKQPLICVLASLRSIDVLISFATVGNDSGDWSRFVGLDSSWRYLNENRAPLTALVATGLKDKLALGPMLLSSDVKADTLVIYLDTVKRLVEERAAILVRKARENGPNLPGSSPRLPNLLQNAEFILENQWQPPNFMIDKCRTELNALTLYCSHDFEFLMIIVFCIYVTIGKEKHNLNFHIRLCQFHVVQAIIRWSSDRNDGERGNTVKPSRIARKTLINILYEFRSIIQRFRFIRTEHETDAEATARRSAEFEEKKRAFFEKSDAWIDKEFRSRRKPAANKSDVTKKSELGCNSREEEQLQVKKDNFRAYFNVNWFVQEWIDDGLPLGVSRKTINTNNVTERAFKTIQQEHLHGRANKRIDNLVVVLLDNALVYDIRKDVSDAKPDHVLRDTLANSMDIWELGQFRPTEKEGQWVLSLRSMDSSITLDTRAPYCPCRAFKQTGNKCAHLWACDLLVHNGDYHTAMTLVDKVLDSKMPSALEDDNEPDEPLSEDELDERDEVDSDVEDEDQRAADIADVAEFQPICSTVKGRSARNRPLQPHRSKKTAKPKLSKSKSNSGVTLEHSGRVDGKATAAIRRLIRDKLNPDQLRPKTSKHTIFENGTTQFGKTRGRPRETKFSNSLSSTKDHAAAKRMAAIPEVIDIEELSDDERPPCQLAPLQEGRLPLDIYDTVQPEERRSNVSAVKDIIERIPNEVQKVDWDVFLDIHAGDHAPGLNLSSLREMANANLWLRASHIDAFSSAINRFQGQLPFNGRSEEVHDLEPTCYAFYLEGGKCAKGIGGTRPTERQQGVSSDGSSRAYLSIIIDRRPASLFALPLYQIILSRTPVLLFPTHVTNHWILVEARLSDCTFRVYDSLCGRENMRKEANESLDSIITFLETRAEGPIERITGGIDRPTVPYRNWKRLIVKAAKAGDQPQSDRYPQQTDGNACGAFVCRAMETLVCAAVAKMEPDWSWGPQVEPGRFYSELRDYMLDVTLHSRLRCDMSSSWFSGSPESPTVSCATRDPDNAMDSRKPHGNTQPGDHVGYSSDDAEEVSQHHISTPVSTRSVTFEGSRLARNVSSSADTVIIQHPQPGGLSHVGSVQGNNMSTARTRLASDQSDSPLNRPTLAFPSFSPVFATRDIEHLPKKCNYSAVPQESSPSAVVTPSKQRHSEAESVAPSSSRRKACSQCRDRKLKCDLGHPCSKRGKASQVFTCPMLLSSDVKADTLVIYLDTVKRLVEERAAILVRSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MI32</accession>
    <name>A0A2X0MI32_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C019g08999 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C019g08999</name>
        <name evidence="3" type="ORF">BQ5605_C019G08999</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY23964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MI32"/>
    <dbReference type="STRING" id="796604.A0A2X0MI32"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033699">
        <property type="term" value="F:DNA 5'-adenosine monophosphate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990165">
        <property type="term" value="F:single-strand break-containing DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000012">
        <property type="term" value="P:single strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032566">
        <property type="entry name" value="Znf-C2HE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486:SF4">
        <property type="entry name" value="APRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486">
        <property type="entry name" value="APRATAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16278">
        <property type="entry name" value="zf-C2HE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aprataxin C2HE/C2H2/C2HC zinc finger" evidence="2">
        <location>
            <begin position="183"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY23964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="299" mass="34121" checksum="30288FA6307664E0" modified="2018-09-12" version="1">MPNPAAWNAVLEQYARLHNPERELPKGVHLLSDSKCVTIFDGYEKAKYHFLVMPRYPFPLESSSSPSSASTSTSISVPSSHLTSLEALRKSPYCLRVLHALQEQARQVQEMIEEEMLKKEGWKWPIHIGFHARESMRHVHLHVISSDLISPKLKNKNFVILRNPLTPSSNSRARHYNSFHPSLGFFLHLTKVIEQVEASQKDTNSTSSYENLLKVPLRSHYTGQQYPTIPKLKVHLEEEWERRGKEEKRRQALPNKDGIKAPSDSERDRGADLVQGRAKKVKVDRTEEDVGASSGDETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIC4</accession>
    <name>A0A2X0MIC4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C009g05801 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C009g05801</name>
        <name evidence="4" type="ORF">BQ5605_C009G05801</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY86125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIC4"/>
    <dbReference type="STRING" id="796604.A0A2X0MIC4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000039">
        <property type="entry name" value="Esterase ybfF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118:SF4">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="67"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY86125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="316" mass="35099" checksum="1FC268742D901BA9" modified="2018-09-12" version="1">MLLFRRATALAPQCGTCTPTWSRKAVTSGVLIAARRSFSCSPISFKPIDLASDVYSPKTKPDQARGPLVVLHGLYGSKQNWRSQAKGIAQHLGRDVITLDLRNHGLSPHAPEAAYSDLAGDVRKFIDDHKLRNICLVGHSMGGKVAMALTLEPHEQIKQLVVVDIAPGTGAISPEFRAYLTAMKEINDAKVMSRKEADAILAKTEPDLGVRQFLLTNLIRNSDSTPYSFRLPLDYLSKQIDEIGSFPFAPGTKEWTGPTLFLKGAKSKYINRRNIPLCEGYFPKMELKTLETGHWVHAEKPREFLQALEEFLDKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJ04</accession>
    <name>A0A2X0MJ04_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C038g11723 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C038g11723</name>
        <name evidence="1" type="ORF">BQ5605_C038G11723</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000061">
        <property type="protein sequence ID" value="SGY92226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJ04"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY92226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="77" mass="8541" checksum="2D0042C42EE284E5" modified="2018-09-12" version="1">MRLPIGLPNLGNSCWATALFELLLCDSDFVEDILRYDQLVAAVGAAPENGKLPTSSRRPCRIARGPLLTRRGSHRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJ06</accession>
    <name>A0A2X0MJ06_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C029g10603 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C029g10603</name>
        <name evidence="25" type="ORF">BQ5605_C029G10603</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ14573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJ06"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="375"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="603"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="23">
        <location>
            <begin position="613"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="624"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="23">
        <location>
            <begin position="637"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="666"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
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            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022741"/>
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            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
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    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGZ14573.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1040" mass="115455" checksum="910F4AE81CA3586B" modified="2018-09-12" version="1">MTADLLNTLAQPYSGDIPFKEFVNKVKIAMTDFQNLGAPLPHWLFAGMLVRSLPAQYDSIVGNLASNIDIHMDWNTFYPKLLMNVEMADSRNKQKESLSARIVDDTSLVARISTTAQKDYSKSYCSRCKALGHERGWRLRPSRNKDASAPASSDSNSNVAAIGVDESALMTYTFPYSRTMPRFPWIIDSGAKVHCVGDKSVLSDVVSEPLKISVADQSQIESPGHGSVTFLTSYGARITIKRVYYMPGAQCGFISIDRLLESMTYAVGPQSNLILSIRGKSILRSLPGRGFVMDAAPVQPIMSSSPPSMVGANRLTGTCTLMEAHRKLGHQSPAAIVLAVKSGAITGITLKDEKVTPCFSCIQAKSKRSPFSNKSTEAPHALYRVFIDLGFVEHPNHHGDTIYLAIVDRYLTAKWTIVLKDKRAETIIKAWSKFQAESERQTGQKIKRVRSDNGREFDNSLFRALLEKQGIIVEFTAPYTPEQNGQVERLNGSLMGLMLWPSRHLFSIVNHILGQGKTAIEVPLGKKPSLAHLQPFGSTAFVHVPKERRSKLAPRSIQGVFIGYSGEYNYRVWVQSSKQVYVSRHVTFLETPSVVTSSQDCADAFDPVHHSQPPHPPHPPPDVLPSTPTSPVVDPTLPDPQPPPVVPIGVGQQGGYLAVVPRKDDDNDDNDGLDDGPDNYHDAEEPLDGEAEVALAPREGYAIVRTGPNPGQFENVDPSNILPAGSRRQPQPPENILPIISAIMVDVLDTPPMFHDKLSYDAYCAAVFAEEDIEIPKTFEEAMKSPYRNHWSAAMVSELLQFDHHGVFQEVKWHEGIRVLGTIWVYSIKRDANGKIIRFKARLVAQGFAQRPGIDYHDTYASVARSLTILFLIALAAAQGLYLEQFDFDCAFLNGKMTEDVYCLKLVGSMYGTKQAPREWYRAVNDLMVSRGYMRATADACLYIKHSGTSFAIITLYVDDGLIASNNQSFLDSELGSLHKAFQLKHLGPVSYFLGFEIHRTKDYILVHQSKYVRTMLEKFDFASPSKRRAVTPMDDRPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJ99</accession>
    <name>A0A2X0MJ99_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C037g11630 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C037g11630</name>
        <name evidence="1" type="ORF">BQ5605_C037G11630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000062">
        <property type="protein sequence ID" value="SGY94118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY94118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="310" mass="33560" checksum="9B5BCFA06BD012AF" modified="2018-09-12" version="1">MIAHSPSTARATPVAIRALLIGAVVAVCTLATCGSALPAHDIQKKDVVIMSTGTRMTSGKISDKLGYQSSGVLIYGGCGRHIAISDCWQMGLNATGNLATRSENGSSAAHSYDLSDPRWEIDDDSLGDDLDTFEEDVTGQTLEKRQASARQGIEIFSLPPAPAESRNLYIWRSYLTNAPSTIVGTNFFHLFQLLRRDSTGDVKGNSYVLMDNVRKQEVTIPLGSFQGRVIEHRLWVMAGTNGSLSYVATDLDHGKRLMTYAATGDTGTNSSIKFGLYRTLPVPGPASGYYGDYQGEFLMNLRLHSTLLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJR0</accession>
    <name>A0A2X0MJR0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C035g11373 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C035g11373</name>
        <name evidence="2" type="ORF">BQ5605_C035G11373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000064">
        <property type="protein sequence ID" value="SGY96998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJR0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY96998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="61" mass="6802" checksum="9CC1810071E4C77F" modified="2018-09-12" version="1">MRVVGGLHHFALGACGFISPPCFIPRSYLLVYLALLSFPLIFALNLGPVHEQRGFPHEHFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJX3</accession>
    <name>A0A2X0MJX3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C002g01185 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C002g01185</name>
        <name evidence="4" type="ORF">BQ5605_C002G01185</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY30838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJX3"/>
    <dbReference type="STRING" id="796604.A0A2X0MJX3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF1">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="424"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="461"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="568"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="3">
        <location>
            <begin position="263"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="3">
        <location>
            <begin position="510"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="665"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="677"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="775"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY30838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="886" mass="97360" checksum="91BF7D7FDD9BDDBB" modified="2018-09-12" version="1">MPDMGLSDTTPLLGKIAAKTEPSLSQLNVYEMIHYAYNLVDDYINFPMTEEYMRTAYVMFEFTDPLDQLLVRNADTPALVYVLLLCRLQFLRERDSALASSSLNITRANMCETLAIRALRREGQKAEAGSDKPGNDSLLAMSKSLVGGLHAFQGASAEVMERVKQKEGFVKAHVVEGVGKTTALELAILGKARNFIKSQATQRVISSIWEGRVTYSSSSFIDILPDRWKVQKISLYNLDKAPVLDHYRLRVPKYRSLIDFSAFVVLFVSFIAVIMDRQNRHETLPVSKLSIHEKWFFLYALGFSLDKLASVAEHGFSIYAAGLTNGLDLMGIPIYAIAFGFRIRSILTEEAWASDQAYAVLSAAACLMFPRQASKRSLAFASISNNLLILSLRAMLADFAWLLGIAVFCFLGFVFALNHLCDGAYSIARIAEWLIFIWFGLDGSGLDASPTFHPILGPVIIVIYAALSNTLLVSLLVAILSGTYASIAADAVGLLPELLQVCLRQCLIQLVAWCRLQAAEDMFRKAVLTFEGVKADSLFDYVPPLNLIALLIMWPVSHVTNPRWFHKINVASTRIASFPILLAIAFYERQSLPNSPLRRSLNEVRGSFMRALPAKWSEKISLLEGAHWECAAVFEYTPDGVEDDEDLNEPLPGDEEDAVDYRASLSNNGANDRPRLSSRASGSLGRPLSRVASSSAPTPPTEEEDESRAARSTPVVLGTEGRRTEVRFTESPPSSSPPASPRKRHGSTTKERLPLNAYGTSGRGQRPSLADEGALDSATSGGSALSTSAPNRYDSPLARMMSYSVEGPPSTILANPRHRRHSGVGLPAHATPMRVNTMPFPGATSTFDPARESGSNDRLLGDLIKMVAELQRTVESLEKKVEGKMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKT7</accession>
    <name>A0A2X0MKT7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C002g01475 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C002g01475</name>
        <name evidence="1" type="ORF">BQ5605_C002G01475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY33278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MKT7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY33278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="48" mass="5681" checksum="5F52FF0E35621C56" modified="2018-09-12" version="1">MPVLFFHSIWKLCRRRRFSSDLLEPITETEFEGLRASIQESKGRLVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKY6</accession>
    <name>A0A2X0MKY6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C031g10892 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C031g10892</name>
        <name evidence="1" type="ORF">BQ5605_C031G10892</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000068">
        <property type="protein sequence ID" value="SGZ05834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MKY6"/>
    <dbReference type="STRING" id="796604.A0A2X0MKY6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ05834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="76" mass="8165" checksum="441334CE85560C3E" modified="2018-09-12" version="1">MPDPPGPPPHPPNAPWAGDVLRDESLNTEARETVTGGTVNPPAWSAQASQARLDHEKSSFFFVELVHHIAPNSCSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLC6</accession>
    <name>A0A2X0MLC6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C002g01665 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C002g01665</name>
        <name evidence="6" type="ORF">BQ5605_C002G01665</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY34669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="5">
        <location>
            <begin position="643"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="298"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="938"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="306"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="954"/>
            <end position="965"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY34669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1538" mass="168856" checksum="8A486A5B370003FE" modified="2018-09-12" version="1">MQLTDGWITRSSVSYLVASVLPQGTDPHAEKTQRISKMATPTADHVSLMGDLYGKVDATNWGVARERLQNVLKGEGRLKHVTGVLDVGPEPLQSEFTRLEGDNRVDDVATYRNQLRLYRQDVDALDQALAQARNTLIVCLGESTFARVKANATHDLWAALDKDLGRASDDFMRSAKLDALFLCEPFVDGEALDPWLANFNRLFEDLVAAHVSRDKAYQRARIDGTSFTQSDFDKWVPAPALSEGVRMDLLKARMPRNLVTVIDSIGTLPSLEQVEGAIRRAALSSSRQIEPIAEALAARVQSRSQPASGRPRSKPSGRPSGPSAPPFLQASRVPGLKERWPHGISHAGRLKLGRMQCRRCYEQGHLGDECTVPSAEVSRRRIAVLAKHNITIGAADVMALVAVDRAPEAQLEDEAYEGYFVVGVPIGDDDTALYLSDIPRYLLDSGATRHMTTRRDLLIDFKPFTTERVRVVGAFNSSAMATGTGTLRFGVDEASIELHDVLLVPGLSAELVSLAGLMKDGYELSNECDAAGKHTGIAISSATSRLSFALDRNHYVLQASSHPPPRADHLALTATTLPTDVVLWHQRLGHPSWGRLVELVRSGQIPLDVAAVTPDQIRLLDQCDACCAGKTVSSPNREPASHPADAPFSRVFADVWGPSPVPALSGARYLCGITDEFSRFRWARSIRLKSDSSAVLQDFVAMSKTQYGGQGVTTLRTDRGGEFVNHRLRDWLAARGIFHELSTAYEHGQMGVQERSWRTIFNSVRAWLHRSGLPPALWDEAAHAAIYVINLLPSSPLQQRTPDSVLHEPSDPVTDTRRPRLDRVKTWGCAAHVPLAPEQRPNKLAPRSRLCYFVGYSSRSKAWRFFDPVRNKVFESSQARFFEDRFFPPAVSPAMPAIPVAVGLSYPPAPLGIGSAAAPPVAEAPAVAPAAAAPPPVPPALAFSNPGPANAPPDGDRSTRTRRPPDYLGFAHAAQHWEFADHAAIQFDDFDEGDPDTQMYSFEEVSALLAKIDSDDTPSVQAALAGPFRDYWLAAMSVEEGALAAKNAFSKPVRPPPGAIVIGSMWVLLVKRNAEGQIVKYKARLVARGDMQRRRGVHINSFSPTGRAASHRLLLALAVENEWETRQFDVSSAYLNGNLGGTEIYMRLPGGDIVRLQRALYGLVQAGREWYKVFTEWILSIGFTRTDSDHAVFVRKEGDRRSFLSIHVDDGLLTGDGDLDGVLCQLKARFEARSTDEASFFLGQSIRREGKTGAAIVNQGHFVDAILEEHHMANASPRPTPLAAPSTLRNRADSGFDPASIPYRAIVGKLLYLSGTTRPDIAFAVSKAARFCNDFTAEHWEALKHILRYLVGTRNFGIRYQKSFQPMSAILEGFVDADHGADPVTRRSVSGYVFMCAGGAISWVAKRQTLVTLSSTEAEYVAMSYAAREGIWLRRLLADLGFEQTAPTRLRGDNQSAITLAKHPAFHARTKHIGIHFHFIRDHIAEGTIEMVWVPTGTMAADVLTKGLGTQKHYQFVHAMGLIDSSREGASWRVVNED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MMW6</accession>
    <name>A0A2X0MMW6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g02137 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g02137</name>
        <name evidence="2" type="ORF">BQ5605_C003G02137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MMW6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY39077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="323" mass="35527" checksum="6001D744C1AEC718" modified="2018-09-12" version="1">MKTCQVVTLSQAQILRLPSLLRHDTRQLALDPKSLIEHRRAHQCAHLKAVLLKGRHGAPTSTAQDFDPTSKAKLSEHGEVHSSVLRGLVQSMGAARLEAMSGVARSIRWTGQGTFSRFSTANETDNIGYIQDGRKEVRMQLRARQYTVFAESPMFGSIDGNVTSAMPLKIGSLVCFRLKRGIVPGSCDASNIGEEQLSIGLIRYMYAKATSNHCDRAETDSLALLSNVVLQEWRVVSKGRYSTHMIDGTTRFFGLDARQIIQSLESSSTQQAEARFCFLRRCNGLRNASVSLNNQMKGVKDVGSKRKAASAGEEPSAKQNRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNK5</accession>
    <name>A0A2X0MNK5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C022g09560 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C022g09560</name>
        <name evidence="2" type="ORF">BQ5605_C022G09560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MNK5"/>
    <dbReference type="STRING" id="796604.A0A2X0MNK5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047443">
        <property type="term" value="F:4-hydroxy-4-methyl-2-oxoglutarate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16841">
        <property type="entry name" value="RraA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.40">
        <property type="entry name" value="Ribonuclease E inhibitor RraA/RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005493">
        <property type="entry name" value="RraA/RraA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036704">
        <property type="entry name" value="RraA/RraA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254:SF4">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03737">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89562">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="113"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605493-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ22920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="244" mass="26111" checksum="6F155D81AE30A4FD" modified="2018-09-12" version="1">MSSTASNPTTSTYAKTPLHLLEALKQLSTCEISDALIKLKIPSGGYVPDLEPFGAFPTSEKDRLVGEVFTVQMVDANDSLAPKLDGGHFVDQALPGCIVFISSPHHIKSASLGGLLAAGLHVKAVQAVVIDGRCRDLQEIRTLGMPVWASSHSTLGQSPFTRPSTIQQPLTITHPNWPTLTISPHDVLIADIDGVVVVPSDKVEQVIELAIKGKQVDQKCMNDILEGKGVAETFAKHRGQTGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPG4</accession>
    <name>A0A2X0MPG4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C048g12365 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C048g12365</name>
        <name evidence="2" type="ORF">BQ5605_C048G12365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000110">
        <property type="protein sequence ID" value="SGZ30455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MPG4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ30455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="71" mass="7846" checksum="897806BB8CE16B3D" modified="2018-09-12" version="1">MPFGSHVSRRWTHSPRLAKPSRAQVASGSRDLSTQLKPLLLADFGERAMWVPGADDHLRTQTPDADCDMGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQJ6</accession>
    <name>A0A2X0MQJ6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sn-1-specific diacylglycerol lipase</fullName>
            <ecNumber evidence="14">3.1.1.116</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">BQ5605_C024g09863</name>
        <name evidence="17" type="ORF">BQ5605_C024G09863</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33276"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="14"/>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ26227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046340">
        <property type="term" value="P:diacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052214">
        <property type="entry name" value="DAG_Lipase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792:SF8">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="16">
        <location>
            <begin position="976"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="184"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="325"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1304"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1304"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1325"/>
            <end position="1338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="SGZ26227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1378" mass="148590" checksum="AA17C7403CE2E5A4" modified="2018-09-12" version="1">MLEPSSRVPSSMAPALVPLNTSSSPPPTVRGESYRPLPTPLASHPGLNSYGSTSATSREAVASASASASASIHNDSGRPQSSTVLASERSYRPPRPSTGALSTISSLLLGNHPRRHGHSRSSPTFPNQSAVPDRARSDPGSASASSSSSLLLRRGKQDLSEQFSLGHPLDSFNCRYGGDKQIDGSADDLGDIPPLPKSQLVSDSSARGARQRRTSSRTLSMDPETTHELPPSPVGLPGAWFDDVNATHSALLLPPPFLDDFSSRQSFEGLLGTREAKLRQARLRKEMHNYAKDRPPRPAFPQSLLSTASKLVTALGPPGGVDSDSYYRTWKDAPNDPTPSSVRKERRRVQRANSAMKGLEVGEKYARKLAERLMAERSRYTDGSLDAEANKGDVDPIEPQVDGPAAELFAGSTFVAATPMSLLQGSPGSHLSPPLFGIATPVLSESVSKRSATRDAEAPLVPPKALLHPNFDDTGEDMSPLPLLLDATHKSVPSSPLDYGYFAIRRRHNAGKAATSLDGSLWDATAAVEGTTHDGEIADLSSSGEASPKQLAVPVASFLLPKVDTRTRPMMDLLIWLLVGSPDVFGGFDQGLASVSGLLGTTLHLVGFAVFVLVHTWALGVSLCAAVRSVALFSHWTFLNLTGRTDLSIVAREYFILCQKEWNLVSAEDGVKLSIGSVLLGLSELMAIQASEFGLAGIVLSKERWIAEGPGKLVLVNGDKAARFAASAECSSLEASSSPIAGGGTSPLLRRFSKRRSLVFNRPSFSRRGTSRRWTVDDGEGLIVTGGGDSILEGTIYNESVDPLAYASPSFTPHPGSATGANTGIPVLDELDDVPPLKLGDALPGDTLPGFSCPPSPVSFLAASLKSPPTRPITDGSDDSTAFFMLLRRHARLATASYGLHTYILAPPTPLFTPSGATLPHRVFSHLGGVDHKAVLHVAIQKHYTGVPAVAGDETDSIYEPQFYLLRDDLHGEVVCVVRGTQSLADIRTDLEAGLEPVELPSLDPSSRGTETFKAHAGILAAARRLLDPEASPLFTKLRKALEDHPGYSLVLTGHSLGAAIASTVAFLVGQYTPAEPESIGGPSVATYATHVLSDHEHNRGHWTVSPRCGLPAHRPVRAICFAHPATVDLPLAKRCSLGQVPLVLSVSLGPDVVCRMGIPQVRELRRVLGRLAKNRRKWLKLQKSAVEARSQSVSQVLPGTKRTQHGKSEILTAWWRWKKLQGGIQQVALEATKNGSHPVQLTKAELEERNRIEEKAWKWRCEMDGIEDDGVHLEGKDQKTLLTRMIPCGKAYHIDRLPVEMERKRKQDTVAERERVQRQRDQQAEEMDQEQEDDEESQLWGLYEVAAPDAFYACPHLEADLVKSHLPKEYLDAVNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MS91</accession>
    <name>A0A2X0MS91_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C054g12621</name>
        <name evidence="3" type="ORF">BQ5605_C054G12621</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="FQNC01000093">
        <property type="protein sequence ID" value="SGZ29341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MS91"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="70"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ29341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="192" mass="21579" checksum="BA0ADC5F52BBDDEE" modified="2018-09-12" version="1">MQTVLRVYHVDVKERFSIFLPPALHTLPIAPHPIATSSLRHPKRSSWKLCNEYGTSFLKKLCSMQYRSRSKSSTARFGGVTVAMAGDTKQCLPVVLKSSPIQIVDACIMNADFWVEVEVLLDFVRLRIRVIGTLNKNRSVNCGSPSRGRSSTARFGGVTVVLTAFRSGPTQFFAEPCLYRINIDESFYFQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MSG5</accession>
    <name>A0A2X0MSG5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C050g12480 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C050g12480</name>
        <name evidence="2" type="ORF">BQ5605_C050G12480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000097">
        <property type="protein sequence ID" value="SGZ29697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MSG5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ29697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="159" mass="17185" checksum="3F827D10F3A6FB82" modified="2018-09-12" version="1">MFVPSVRSSKAKIQRQVVGLNRAVASKPRATSDRGTGDGWATATQSSKARPTTTLSPATGANGMTLTNAFAGLEEEDMEGEGDEENEENMAEGGGGGEGGQKEEMRSGPAEKEEDGSQEEEETEDEQTMEVEQGSSALSSKPNRTLGWRRLYRPRYHRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MSK6</accession>
    <name>A0A2X0MSK6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NADPH:adrenodoxin oxidoreductase, mitochondrial</fullName>
            <ecNumber evidence="8">1.18.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C002g01077</name>
        <name evidence="12" type="ORF">BQ5605_C002G01077</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>2 reduced [adrenodoxin] + NADP(+) + H(+) = 2 oxidized [adrenodoxin] + NADPH</text>
            <dbReference type="Rhea" id="RHEA:42312"/>
            <dbReference type="Rhea" id="RHEA-COMP:9998"/>
            <dbReference type="Rhea" id="RHEA-COMP:9999"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.18.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ferredoxin--NADP reductase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.6" evidence="8"/>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY29703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MSK6"/>
    <dbReference type="STRING" id="796604.A0A2X0MSK6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055275">
        <property type="entry name" value="Ferredox_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021163">
        <property type="entry name" value="Ferredox_Rdtase_adrenod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467:SF1">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000362">
        <property type="entry name" value="FNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 8 10" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="233"/>
            <end position="236"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="277"/>
            <end position="278"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="484"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="491"/>
            <end position="493"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY29703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="575" mass="63172" checksum="857B298F2CD9B48D" modified="2018-09-12" version="1">MTRILPRRLARPRTLPTSLRFHLPPSSRPYSSTPSSNPSLSLQSHAYRIAIVGAGPAGFYTASRLLSLPGSENIKVDLFELVPVPFGLARFGVAPDHPSVKNCVHKFTETAQDPRLTYYGNVQISGSTLTESESSASTSSRASSIVPNLFLSPHAYQLPISTLLPKYDTLVLTYGASLDRSLGNIPGETTLLGIDSARNFVNWYNGHPLSTFNSTPSTSLDLSNTEHVTIIGQGNVALDLTRILLKPIDDLKPFDIPEHVLAELARSKVRKVEVVGRRGVLQFAGTTKEVRELIGLNQQGVGFRIDVDLVNEGLELLAKEKGMVDARIRQRALTLLKKGYEQNLQNGENLKEWQVKFLRSPIEFLASTITTADAISESSTPTLSTILDPQRVRAVKYAHNRISFTPSTTPLDPSTWAVETTSERSVVPTDAVFKSIGYRSIPIPGIPFDPHQGIIPNSQGRVTLAPSSKEEEEEPRANVYVGGWLARGPTGVIATTMFDSFRLADQIVHDLMHSTSSSSGVPKEGMRLSSVEDGKRIVSWKDWERIDEVERERGAKLGKSREKLCTVQAMLDVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MTN2</accession>
    <name>A0A2X0MTN2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C028g10481 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">BQ5605_C028g10584 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">BQ5605_C040g11916 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C040g11916</name>
        <name evidence="2" type="synonym">BQ5605_C028g10481</name>
        <name evidence="3" type="synonym">BQ5605_C028g10584</name>
        <name evidence="2" type="ORF">BQ5605_C028G10481</name>
        <name evidence="3" type="ORF">BQ5605_C028G10584</name>
        <name evidence="4" type="ORF">BQ5605_C040G11916</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000080">
        <property type="protein sequence ID" value="SGZ12127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000080">
        <property type="protein sequence ID" value="SGZ13658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000118">
        <property type="protein sequence ID" value="SGZ32794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MTN2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ12127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ13658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ32794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="58" mass="6557" checksum="08AB8F8B31589318" modified="2018-09-12" version="1">MITNNLSQTFYLARRPGLSWAPLRSRARSEAGDDPSQDQRRAVPKSATVVHTCDEWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MVN0</accession>
    <name>A0A2X0MVN0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C003g02229 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C003g02229</name>
        <name evidence="6" type="ORF">BQ5605_C003G02229</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MVN0"/>
    <dbReference type="STRING" id="796604.A0A2X0MVN0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052604">
        <property type="entry name" value="Mito_Tim_assembly_helper"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28082:SF2">
        <property type="entry name" value="CHY-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28082">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05495">
        <property type="entry name" value="zf-CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="CHY zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51266">
        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHY-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY39499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="119" mass="13981" checksum="04A4A8C13E451F3D" modified="2018-09-12" version="1">MCKHILNVQAAIRAPCCRQWFDCAECHAEKEDHDLTKTTEMAFLCKKCKKAFRKDMTKFEESDEYCPHCDNHFVIDAKTPQRVIEFETEDLRVDARGLRDERQRNLHTSDIDAFVDQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MVW9</accession>
    <name>A0A2X0MVW9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 14">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="10 14">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BQ5605_C003g02339</name>
        <name evidence="16" type="ORF">BQ5605_C003G02339</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10 14">
            <text>6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10 14">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10 14">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="10 14"/>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY40230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MVW9"/>
    <dbReference type="STRING" id="796604.A0A2X0MVW9"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000002">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.320:FF:000002">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000007">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006113">
        <property type="entry name" value="6PGDH_Gnd/GntZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006184">
        <property type="entry name" value="6PGdom_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00873">
        <property type="entry name" value="gnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006765">
        <property type="entry name" value="PRK09287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000109">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00461">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="5 10 14" id="KW-0521">NADP</keyword>
    <keyword evidence="6 10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 10 14" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase C-terminal" evidence="15">
        <location>
            <begin position="180"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="34"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="76"/>
            <end position="78"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <begin position="130"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <begin position="187"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SGY40230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="495" mass="54126" checksum="5B25AB037C106B67" modified="2018-09-12" version="1">MSAVADIGLIGLAVMGQNLILNMADKGFTVCAYNRTTSKVDHFLENEAKGKSIVGAHSIEELCSKLKTPRKIILLVKAGDAVDNFIEQLEPHLEKGDIIIDGGNSHFPDSVRRVAALEKKGLLFVGSGVSGGEEGARYGPSIMPGGSPAAWPHIKEIFQKTAAQVDGQPCCNWVGESGSGHYVKMVHNGIEYGDMQLITEAYDILKRGFGMSEGEIADVFENWNKGVLDSYLIEITTDILRYNDDDGVPLVTKILDSASQKGTGKWTAVNALDLGMPVTLIGEAVFARCLSSIKQERVRASKVLGGPQIEAFTGDKKQFIDDLEQALYASKMISYAQGFMLMREAAAEFKWKLNYADIALMWRGGCIIRSVFLGDITAAYTKNPDLENLLFDQFFNKAILKAQSGWRRIIAQTALWGIPAPAFATALSFFDGYRTERLPASLLQAQRGEYQADYFGAHTFKILPEFVSEKYAEGADIHINWTGRGGNVSASTYSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MVY0</accession>
    <name>A0A2X0MVY0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C004g02792 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C004g02792</name>
        <name evidence="5" type="ORF">BQ5605_C004G02792</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY67630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MVY0"/>
    <dbReference type="STRING" id="796604.A0A2X0MVY0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051714">
        <property type="entry name" value="Znf_CCHC_NABP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23002">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="190"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="234"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY67630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="291" mass="30222" checksum="A1FC2F7CBA87163C" modified="2018-09-12" version="1">MIHLGQPPRLIPATDTPPPRLASHPRSIPFSRKGCFKCGSLSHIAENCSSPTRLCYNCKSPDHESNVCPEPRSNDSKQCYGCSGIGHLASECPTLRQNASIGGQKCYSCGQFGHIARSCPNAEGGAVPSHPNAPPPNAVQRNGFVPRGGFRGEFRGGFRGGFRGGFQPFGGSRGGLNNHVGFVGRPGSICYNCGQPNHLAKFCTAPPQQNGAIGGGVKGVGVMGMGAPRPPKTCYACGVEGHIARECPTVVATTLVGAPAVTTTTTIADPTAKTTTTTTTNAPDEKPNVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MYT6</accession>
    <name>A0A2X0MYT6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C001g00784 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C001g00784</name>
        <name evidence="9" type="ORF">BQ5605_C001G00784</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY49475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MYT6"/>
    <dbReference type="STRING" id="796604.A0A2X0MYT6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000010">
        <property type="entry name" value="Acetyl-CoA acetyltransferase (Thiolase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF107">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE, CYTOSOLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="7">
        <location>
            <begin position="6"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="8">
        <location>
            <begin position="277"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="4">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY49475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="399" mass="41312" checksum="C8F46E2641F89A5A" modified="2018-09-12" version="1">MSSPAVYIAAGRRTAFGAFGGKLKSYTAAQLGGIAGKAALADLPEGTKVDSVHFGAVLQSDPSGPYLARHVGHLSGLPVDVPACTVNRLCGSGFQVIINAAQEIKLGEADVVLTGGAESMSLAPYTLSGASRWGTRYGVDLKLEDSLAAALTDRVPNPTPMGITAENLSDKYGITREECDAYALQSQQRWKAALDAGAFKNEITPISLPSRKKGAPSEEFTQDEHARPQSTLESLAKLPSVFKKGGTVTAGNASGICDGAAANVVVSEAALGKYGIKPLARVLATHVVAVEPTIMGIGPVEAVRGALAKAGLKIEDIDLFDINEAFAAQWLSVQRELGLPNDKSNVFGGAIALGHPLAASGARIVNNLVHNLHRLDKKYAVGGACIGGGQGIAIVLERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MZ26</accession>
    <name>A0A2X0MZ26_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00904 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00904</name>
        <name evidence="2" type="ORF">BQ5605_C001G00904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY50601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MZ26"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="522"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY50601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1345" mass="151925" checksum="38A66F11E4F82639" modified="2018-09-12" version="1">MIKHLITSWNVRRCMGIPEKRRDIYTYLSTFKASAILLQEHLIKPELWQCIKDEYEGKAFISKHCLTLIPADSPLIDAEILRTHSALDGRILVTSFRLRGDIRILEINNLYAPVDTKQRLTFFDKLNFHRTQSTHLRLLGGDLNDCPLPAIDRRNQGRHGHHWPILIGKLDSPYTDCIRFKHPLTPSFTRPNIVRKRPKSFSRLDYFLLQRTHQKRLVQASTIYDHPKDLSDHRPVSIVLVLSDERGDAAQPNNSLPTTSNQLHRINAATFKTAAFQGMLEGWLEGASGEEPVGELEVVLGNCEKEGRELARREHRERVERMAVLVGRVQDLEALPVMGDEETAEWTRTTEELRRAVNERARQLRIRAHVPEIATEERLSRPVHAKLAARSSDSKITALRLPNGELTHDIDVALDHTQAHFQRLYNLEPRDRDHVERLRDDFLAPIRSARTCDDPSSDPLFLRRLSEAHIELLQQPITEDEVVAAIATTHPGRSPGPSGVPYELYHTAPRAWAKALSRAFNAMTERGSLSPRQGQGLVRLLFKHHKIGADRAELSSYRPITLRECDYKLFTKVYVARLNHVLPDLLPPQQHGFVKGRRSADASFHLRLLIEELGARGTEFPDAALLSLDQSSAYDLVEHEWIFAIFDALGAPATFQRVLRMLYSGDSTTARYIINGFLTPPVRLTCGLGQGDPASSSVWDVVFQPFLDALHRRGIALNLSLPTIHPYPQSRAITSLAFADDVVVAVAGSESLTLLDDLALDWRLATNGRLNTDKTVVLPIGCRWEAGDRPLVVKAEGESLEWIGLSFDPTGNTELANVNLVARLEAVLDSARDRGLTHHTRAFYVNRYAIPKILHILSADIPPLEVVKELDRILVDFVRGGKRRSCYGKDVVFTPRFKGGLGVMRMQDVVDSVAARVWDVLLGGSDAIWQGLARAAIVRAHPAPDFDLATDAWPCDYTPIRTDLHPRWQAVLKVPSTHNAQVKPRTLTLANLLALPIKLHTLHYLPGAPAVSRSPYDADYAAFANYAKVADLFRRELCPGGGFHLWTPPTDVVVSNSEYDQRGRPQREHIVAWYRHAINRLRFTPIAQPVAAVRINGPPRVRPRFEVRPTTPLESILPHPIDPPQRLPRPALPDQSTQYNLLSMDRPYTIRRVRRVLNAKAFTDTIGFRDSLQPDDIKGFWKGVNSKALTAREREVWFKLVRNFTPTRSLQFHQKHDDSPACLVCGAPKDDREHYFFDCVDSGNVWIAARSVLCDALGLDTIDNTHYTAVQRMFGLPKLKASLRDQEGAGRTIEIFTGLVLEMISSGRWGMQKWGTRMEGVGRRRIILEERLKLRAGGAWGRRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MZU3</accession>
    <name>A0A2X0MZU3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g03970 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g03970</name>
        <name evidence="2" type="ORF">BQ5605_C006G03970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY55116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MZU3"/>
    <dbReference type="STRING" id="796604.A0A2X0MZU3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY55116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="274" mass="30300" checksum="2ACFE107DCC56DB5" modified="2018-09-12" version="1">MFPKHARLDGPKSFTNWLCQLRLTLPNQLRSYVLDGVISATWTAEQLPARDNAAREIIVGSIDSADVSAALDAIPSDQLSAPCIFATLKARFAPDDATRTLELFARLWDFKKMPASVEAYNTWLREYMSVAQEIRDAKTLLNDVLATHVLAMVLSCLDSFRLTFTDEQRSQRELPKLTMLTDRIRIQLRLAGLSIRQSPRLSGEVESQTEVMRRELRNKKGARAGIGPAAGEIAGPLRQSRASKQLRASKSSPQGGGLAGSRNDRGAPVELRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MZX2</accession>
    <name>A0A2X0MZX2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g04000 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g04000</name>
        <name evidence="1" type="ORF">BQ5605_C006G04000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY55308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MZX2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY55308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="78" mass="8317" checksum="163F0B6621C8BA9B" modified="2018-09-12" version="1">MCGGGTRAAADVSAAPLLSVKIVVQETGRESLQMTLRQWQNWMAEGTTLQCGRHAKPVVWEAEDHVPGCFDGNGTSAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N0J2</accession>
    <name>A0A2X0N0J2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g04210 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g04210</name>
        <name evidence="2" type="ORF">BQ5605_C006G04210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY57021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N0J2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016169710" evidence="1">
        <location>
            <begin position="25"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY57021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="256" mass="27534" checksum="4283A49FC3AAFF6D" modified="2018-09-12" version="1">MVFIFPRASFVAAALLLQSTLSLATPSSEDAVHEHEKRITCHNNEVAINNACVLCASLYKNASTCTRSAPLTCTYGVVDSTRNCAPVDCTKLPGTYRTDDAKQCLACPDAPNGALTCNSTTTFSCLPGYDFHGGQCYLGVPVAKFVGYGLAKPFLAKQQPFKPYLLMDTVHMYCLAQHPMARVAPHTGFNSPMRPTCSGQIGAIDQPLVTMDDHSAAVFLRGWCEDLSTNPYVTANRANSSCVQSHLLPDGFASLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N216</accession>
    <name>A0A2X0N216_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C007g04781 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C007g04781</name>
        <name evidence="1" type="ORF">BQ5605_C007G04781</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY63178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N216"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY63178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="229" mass="25318" checksum="B0D5DE1FD08CA947" modified="2018-09-12" version="1">MRREMAASLRVSETQVAAFAASDLLRDANGYQDWVLTLCSRLPFDVLEYLKSGVPHPSWPPSYVPLWDHYARASICAAVDPRMVLPGLSRYFGDAHSGHKIWVALRMRYGAVSAVDLLPVVARLFSPEPMPDTPDAFLQFRDRFENDSRLLADSNVTTDSLLASHLLARMPPSLSAWRTTFVNSQGTSDTLPPAAELLDRIHREIKARPAEAPAVAVANPKQLLGLVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N288</accession>
    <name>A0A2X0N288_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C007g04851 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C007g04851</name>
        <name evidence="1" type="ORF">BQ5605_C007G04851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY63937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N288"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY63937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="61" mass="6872" checksum="A64B85BDD6E08E2F" modified="2018-09-12" version="1">MQTLTSPCPQKYLRTNHHLLPIYDSPGLYSCRVGGPSNQAPSQKHDVIAWLSLINNHLDLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-11-27" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N3M6</accession>
    <name>A0A2X0N3M6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar-sorting protein SNF7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Vacuolar protein-sorting-associated protein 32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C004g03054</name>
        <name evidence="7" type="ORF">BQ5605_C004G03054</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY69727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N3M6"/>
    <dbReference type="STRING" id="796604.A0A2X0N3M6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF10">
        <property type="entry name" value="GH13992P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY69727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="221" mass="24289" checksum="11F1D5D3C0BB38F5" modified="2018-09-12" version="1">MSSWLSYFTGSGSSRGSRDSTREAIVNLREHLMMLDKKEEFLGTKIEAELRKAKANATSNPRVAKQALRQKKLYENELDSIAGRKMTLTTQVNAIESANMNKETLEAMKKGADVLKGIHGKLNVDKVDATMDDVRNQLELTNEISEAISNPAGMGIDVDDQDVLDELAELEQEELNNRLAGAEAAPLHSPAAAVPIKTPAQAIEEDEEEAELRQLQAQLAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N4S2</accession>
    <name>A0A2X0N4S2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C005g03466 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C005g03466</name>
        <name evidence="9" type="ORF">BQ5605_C005G03466</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY76083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N4S2"/>
    <dbReference type="STRING" id="796604.A0A2X0N4S2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18870">
        <property type="entry name" value="NUDIX_AcylCoAdiphos_Nudt19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039121">
        <property type="entry name" value="NUDT19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318:SF0">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE NUDT19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318">
        <property type="entry name" value="TESTOSTERONE-REGULATED PROTEIN RP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="8">
        <location>
            <begin position="89"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="24"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY76083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="476" mass="52421" checksum="C4A16A71191EEE94" modified="2018-09-12" version="1">MLAATRSTIPRHLFPRTLLIAYKPQRPMSTSSSSSSSSAVGRPDGIKSATFSALSSGASRTGATSSLNGSPRPPRPPQDAIEDGDPITVPSLSASLVLIAPLQERTADGYDYRVLLLKRNARSTTFFSAHVFPGGNLDPIDRDQSAWTGLLDKIENPEEAKARAVKLCALREAFEECGVLLLDGEGNAKQRWIAISDTEKKAWRNKVYKDGKSFVELFKFLSADDGQPALPALSSLQYRANWITPANMKRRFDTHFFISILPPSSPTSRTSTTKDPIHSEHIASADGGETVSADWLTPKEAIDRTLLHAQLQQGPPKEGEESDAASRSLILFPPQFYLVAELVRTKSWKELVHKPSSGVEKGVHNFAPRHIQPFEPEVKGVEDSQGKFRAATVLIGDPEHSKTDQSTCLKTDRHRTYVLLPAKRRDPEWKVKPPLGLTVMGCHREGMGRLFGEGWDVTMREGDTGETSSAKRKFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N9K7</accession>
    <name>A0A2X0N9K7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C027g10390 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">BQ5605_C027g10394 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C027g10390</name>
        <name evidence="3" type="synonym">BQ5605_C027g10394</name>
        <name evidence="2" type="ORF">BQ5605_C027G10390</name>
        <name evidence="3" type="ORF">BQ5605_C027G10394</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N9K7"/>
    <dbReference type="STRING" id="796604.A0A2X0N9K7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ28622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ28643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="439" mass="45140" checksum="3A23FA4B8D1AA838" modified="2018-09-12" version="1">MSARPARPNSPEPQHALSPPLPNGDNTGFLSAGKCASVCPTGFVNAPSTRTCVTCNRFDNLAATCTAGKIATCNSGAYLKLNSGQNDCIACTSVNSFATTCTSATVVTACTAPYTVSADKKSCVLGSAWSYYLASSIPDVSYDSNVQTPIICGRGAVSKGSQVAVFDTSSLTCFSTSSSATTAVPKLTWDADSTVMVLGSCKTNNALVPSAKTRCRDVTLTASSCTLTADKSACSTLLTSCTGLQFRNLNGVCQNCASTYQDSLTCDLFNGATTCIDGDFLNNGTCSSCSTFDPNAASCAANGTVSDCNNGWVLSDNACVVDTSAPASAVDTAWSYYPDSMVASLSVLNTDSADQYDCAEAIYASNLTMGAFDPVEGNCYAANATDPILSSITDVDGASVFVLETCAANQASVPTEQGNACYDLTLDDQSCQVNGMPCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NA94</accession>
    <name>A0A2X0NA94_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C032g11066 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C032g11066</name>
        <name evidence="2" type="ORF">BQ5605_C032G11066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000067">
        <property type="protein sequence ID" value="SGZ04472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NA94"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="473"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ04472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1085" mass="119538" checksum="25DB22D68CC79278" modified="2018-09-12" version="1">MSNANNPHPEALPSSAEATISPSNRPHPNLIYIMNQPPFVPHPIAQYPVPNPHIPSQLDLMGPDSQLANHHATALALATVPPSASSTASPLLPRPAVPTQSQHAAAPVTTEYASTSPSSQAFPRPLPIPVLQSSEHSSQAAPHLQSRPQLAESTPWRNSVVLADNPNPRPNHAPQNPQPFFDDILDRVTRPILGRTSGSTSANRRPRVAASSRLSNRINPIAPVDTMRRLHDDFTAQCRGRPSQEQANLLLTDARFKGLLFHGRVSQLSDPQAKPSGRSGCDVTPLFLANSDEDNDGNRASPVLFPRSGFDTIVNMECASKAPVRIPKHWTTDREAMTAVAVIIESLPALAFHLDRAAFNLERDCTHLQDYFIVARTSSERIEGKSCFVSRDNANLKPLSLFPHKSSAEASELATILSHRPITFGEPNSKRRVLALYPTALQHTFGIGFPFSALNMMPGDCYAPDGGNGDNGNNGINGDNGNNGDNDDDNPMCASLLRPPSTNTSNDRDREPTALSSDRDLAQGVTNHSRAGNSADPIAQASTDFDLEADMDDLLPPFGSTGRGEIQEDHTQSRTRRRARSHDSPSIRSSHSREMEDTDSSEDDQYSYPRRQRPRHRIPSLMRSTSPSGDRQAGGRVIAASESVTTITHLGNASSLPAMPPLRDGGYSDRDWVALSDCLRANVKRTRRESEPHISTLSHCFHYTSPTQELNSQHLFNEFRKWLSKISTVDIVSKQSGFTVAWDLPGIQIDEDLSMTCGFAPLLHLINGTLTAIFTSSDNVFNPSLVGSTARKDGKEGSTLLYVFNDDLPAEIWNQECVGERMQEVLRLLALALVHLETWPDHIHPHMIFAKSSEDSFKIDDLVEWVCPNLLARVCRILRTSPTLVKDMDEYTRIQVLGLYGRAKFTNMGESEVSEKDWTLLEESRANRSLLGDLYRNRVLGKTAKTLAQRTDIYFRLSRCTRTVTDILLGLHSMAESQDLTHYAMLCNMRAWPPSADRSFKFTKEIYQVEWCGASQADIAGPSSRPYNALPARIRGMGEAVLLKALESMSSEEAVGFCKIAHPTHGFPVADQNDNVKVSVQWLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NB67</accession>
    <name>A0A2X0NB67_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C105g13173 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C105g13173</name>
        <name evidence="1" type="ORF">BQ5605_C105G13173</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000078">
        <property type="protein sequence ID" value="SGZ11395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NB67"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ11395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="103" mass="10714" checksum="7D8268E70AF5CADC" modified="2018-09-12" version="1">MKSLPSYSSLMSCQRCGLMKCSCMRMADALKRDSALGGGDVSKRGGRQDIVLGLVVGPSFLSATPLCFPSATFVTPTGIAAAADIDLVTLAPVPSLTTTRLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NDD4</accession>
    <name>A0A2X0NDD4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C022g09445 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C022g09445</name>
        <name evidence="2" type="ORF">BQ5605_C022G09445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NDD4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ22177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="675" mass="75216" checksum="250763C445129308" modified="2018-09-12" version="1">MTPLAPCCACLTASTKRQAARTLSTSATVRVPVTNAPTSFAPIASTSRLPGASYSIDGASLARPDQPHGARESAQMGPRLPVSAPKGPSRRMLAASPAELAFNLAHLLRGRQPKYALHVYLTELSRSPSFVSSENIVSLLRLFIEYGQISCALEALKASRRKGWAIPASIAKLVITNSASQIVSNPAYLETLIEWVKQSQEPTEDGMERSAEDRKLGAHFALAAMDALKRVGQSDAALEIFANHIDSAHEGDIGRPEMWAEAIRCKASDRDIDGAQELFFQWRILWFESRGSETLPVLETTGSSLHRRSKGLMTHTGGQDLTILESPPAEPYLALLNFLAIATYRRPAERDAAYLIVSLLHRDCVRLSTPVFNALLRVELQRARFTSFWGLLARMMQGGWQRDHMTWRLCIQALIQPQVRRESSMLRASSSRGLRIAHRPNRVEAHRASPLQREAGYPSQDPPTARALYRSFLDAHREATGGKRLLVLPGLLKPIMSTITLNTFLKLFLQRQDWVAMAHVLEAFKVYGLDPNERTHGQVVVGLVKLWERGKVEGMIEEEDAMDRGQLTWDNRERTLKAQRQSTNGMQLIARILQKRREKHAAWDKEAVSWDEEAGEETINVASGKTPERVATKELRDVGYLIDLLKSCSGASEDEWVQLRADALVEFEQSALKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NGR1</accession>
    <name>A0A2X0NGR1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Imidazoleglycerol-phosphate dehydratase</fullName>
            <ecNumber evidence="4">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C050g12506</name>
        <name evidence="9" type="ORF">BQ5605_C050G12506</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="4"/>
    <dbReference type="EMBL" id="FQNC01000097">
        <property type="protein sequence ID" value="SGZ29798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NGR1"/>
    <dbReference type="STRING" id="796604.A0A2X0NGR1"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.40:FF:000001">
        <property type="entry name" value="Imidazoleglycerol-phosphate dehydratase HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="entry name" value="Imidazole glycerol phosphate dehydratase, domain 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133:SF2">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE HIS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00954">
        <property type="entry name" value="IGP_DEHYDRATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGZ29798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="238" mass="25539" checksum="8E6B5BB3AC57665A" modified="2018-09-12" version="1">MSRTIRSASISRKTNETDIAITLTLDVAVGAAQEINISTGIGFLDHVSLPCSNSRVVSLLHADVDSAMYHALAKHSKMSLTIKCKGDLWIDDHHTAEDSALALGEAFKLALGERKGIRRYGTGFAPLDEALSRAVLDISSRPYFCGDLQLKREKIGDLSCEMIPHVFQSFAQGAGVTLHVDVIRGENDHHKLSSTGQGEGWSLPTAESAFKALALAIREAIQTDGSDDVPSTKGVLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NMV2</accession>
    <name>A0A2X0NMV2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C010g06111 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C010g06111</name>
        <name evidence="4" type="ORF">BQ5605_C010G06111</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NMV2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037959">
        <property type="entry name" value="MFS_SpdSyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43317">
        <property type="entry name" value="THERMOSPERMINE SYNTHASE ACAULIS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43317:SF1">
        <property type="entry name" value="THERMOSPERMINE SYNTHASE ACAULIS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="642"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY14233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1194" mass="132611" checksum="8D5129985B5682D7" modified="2018-09-12" version="1">MLRASWRMGLVNDLKTVKGPWSALATLAGAMGIALALESSSLGSFNNRWLPYTGIYPTLVPETTVMNIHSLALILIVLVPTLRRQVDPPNGLSTSSISTKSSVVLVCLTASALLASIFSSPTCHLKPYLPSFFCSKPIAIGPVRILASQQSITGRVVVGETMVHNLTLRYLRVDHSLLGGLWMMPAKQDVATGRPSRSAVDDVEAELRRAESIYSTFILQELVRLARPPRTTGGVQEEKALVIGLGAGLIARSLEQHGIVTSLVEIDPVVYQYARDYYGVKNMRGEIALEDAIGFLSRKQVQETYDYIIHDVFTGGTVPPSLFTMEAWALVKSALTPDGLVAINFAGTVDSPTSHVVLSTILASFYHCIVLGDGGLTRSTSGFSNLAIFCSAQPGRKVVLRPAVASDYLEWPSPNLRRKILGNFQDFVQDLHELVPRNKLEDVLRGKKGRRRLKDLQRGSAELHWGLMNGVLPLEFSIQTPNDPPAAWTSTKHRLLPELQALARTFARFRRGGSEQERADHSRYGAALRSRLDPSLAGPSSIFIRLRKVRASDLIPSLTVNDVVHSDPDSMLGAASDYFERVYEDRPIDDAALKAIIDGLASTRLSPADSLKLEEAYPLEEMTKAQAAFLCAVGLGPKARQWYRATYTNQSASIFLNGWLSATFDILSGVRQGDPLAPSLFVLAIEGFACQIRLRVKGIDIAGLQNVRELLFADDACCALHNLSDLDHLNRAIELYERASASKLSNVKSFLYPLGAFRDRSIAPDLGTWRLSDSQFRYLGIQVGVEIAEDAGWEDVKASTIARIRSVPMYDLPYAAKCSIINIYCYTKILYYSRFLPAPKSVVKEIEEAAMLAIHGRASDGTQRRPKVSRSRLCTPLDHGGFGLIDLPRRLAIDHAKWVFQLRAPDGCFTRHLFDIRIRLQAPKEPTPFTLSRPVPNQHQKTTKLLPARWVRYFEAWALVTTLNPPELSKSQNLEQWATHILCFPAGHGIQLSVNPTLFRGPDGEVMTPSSFVNAFKRHQVFIFPPIFPKGHQKVFDLPEQRWNAWWKALRKVRRVHSDAEDTGHLLSLGSLHPGSQVASPTSPHPNNRSTSCVMCLLEAPECLVHLAVGCPFARRLWSALSPTPHPVFVDFVCPVVSRSERRLVELRVLFFHSIWKLCRRRRFSSDLLEPITETEFEGLRASIQESKGRLVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NQ63</accession>
    <name>A0A2X0NQ63_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C012g07006</name>
        <name evidence="8" type="ORF">BQ5605_C012G07006</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NQ63"/>
    <dbReference type="STRING" id="796604.A0A2X0NQ63"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF113">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015796966" description="Carboxypeptidase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY16839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="535" mass="59270" checksum="04405929A2EA5AD6" modified="2018-09-12" version="1">MWTSLLLPIAFAATSVLASGDLPLQARTQITFNSGSLPGAIERGSDQVDKWVSQGVRQFDSFVHGNGMTYELITHTDFPKYSIRLKEPKLCDDTVKSYSGYLDLDADNHFFFWFFESRSKNATKAPLMLWLNGGPGCSSSTGLLFELGPCSITDEGKSTTWNKYSWTESANVIFLDSPINVSFSSPRLEPDRRLTRLSYSPRVQVGYSKGSKAVATSQDTAKDVYAFLQLFYEKFPKFSKNDLYVAGESYAGTYIPNIASAIFNNNKNLDFTKSKSIPIPLASMAIGNGLTDAYTQFASIPTFSCGGGIHEPIFDEQTCASLPSKVGTCQRLTQYCYKAPSRFTCVPATLSCWQTAGPIQSSGLNPYDITKKCDRDGEDGPLCYKQMQWIETYLNQAEIKKELGADPDTPFTSCNMQINQAFTLNGDVAHNTAALIPEMLEAGVRLLVYAGDRDFMCNYIGNLDWTLALPWSGQAEYNQAKLHNFTMPDGRAAGLTKSYGGMTYMQVYGAGHMVPYDKPKESLEMIKLWMQGGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NV63</accession>
    <name>A0A2X0NV63_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C012g06820 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C012g06820</name>
        <name evidence="2" type="ORF">BQ5605_C012G06820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NV63"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY16245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="176" mass="19328" checksum="A7EFCC983DDE8069" modified="2018-09-12" version="1">MPKIFSHLGFPLRLRQATAAPAAGPSLESSTSAAENKLDLDPATEKDGQKGPAESLIETEKRVLRQANAHASAERHVQVDAAFVDVDDLDPEFLDPDGKERVIQTAHDYSTRLISLEDDQTLPVHMRRLTCFGAILGEILTFRPQVYEVSSLFLQIIAYSAGTKLPGFSQAGCWKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NZT5</accession>
    <name>A0A2X0NZT5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C019g08823 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C019g08823</name>
        <name evidence="4" type="ORF">BQ5605_C019G08823</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY22585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NZT5"/>
    <dbReference type="STRING" id="796604.A0A2X0NZT5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="3">
        <location>
            <begin position="2"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY22585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="364" mass="39319" checksum="DF75C923469E9EB4" modified="2018-09-12" version="1">MQSFSLTTFSPSGKLIQIEHALAAVGQGTTSLGIKVSRTANHLSSWRKFPLNDQRLFNRVVAVPGATRHPSSHSTSSMGLPLIRFDPSNGIVLATSKKPPSPLVDDSMLEKASPIAPFCKGCRFLARSHPYDNHHLSYHVTYATPILPAAGSVDVSLVCPNIGLVYSGMGPDFRVLVAKARKSAQSYWKIYGEYPSTRVMVGEIASVMQDATQSGGVRPYGVSLLVAGYDKAKGHTLYQVDPSGAFWAWKASAIGKNQVNAKTFLEKRSVARSRRPSSKICFSDIFLLVGSRSYNDDLSLEDAIHTALLTLKEGFEGVMTEKTIELGIISTAGFEGAQHVLGAHGTGSTDSPCFRKLTEQEVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P152</accession>
    <name>A0A2X0P152_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C002g01158 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C002g01158</name>
        <name evidence="5" type="ORF">BQ5605_C002G01158</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY30496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P152"/>
    <dbReference type="STRING" id="796604.A0A2X0P152"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="4">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="70"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY30496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="387" mass="41671" checksum="C95347899B8CEB89" modified="2018-09-12" version="1">MSRRYDSRTAFTIFSPEGRLYQVEYALESISHAGTVVGILAPGPAATPFTSSTEVSDAMAVDTAEVPADAAGVASTSTQSTVPPTATASTSAKPELSAAAKKKEAEAKAERERKYPGPQRAGIVLAAEKKVLSKLLEKEKGSSEKIFLVNGWVDLNVPASRVAEAPMERQVADPTTFYRLRSNVITGVAGYNADANSLVSYARNAAQGHLSAYNEDMPVEQLVQKLCDLKQGYTQFGGESIPRNVDGYRRARTLTIVGDHTGLRPFGVSFLFAGHDPHHQFQLYASDPSGNYSGWKATCIGANNATAQSLLRQDYRDDIGLNESLGLALKVLSKTMDSTTLDSEKLELATLTLDAQSGLPFAHIYKPHEIDALLEKEGLKKASEVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P1F8</accession>
    <name>A0A2X0P1F8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g03917 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g03917</name>
        <name evidence="1" type="ORF">BQ5605_C006G03917</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY54842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P1F8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY54842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="85" mass="9257" checksum="C48DD5C52673B503" modified="2018-09-12" version="1">MITQTARKSARNEPSPPIRDIRLFFFLTGAHKLQSFGLAGTATKRAKGGYKATTASSWVKVKPLRAKSAAQIKTRRAPNADSNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P1G6</accession>
    <name>A0A2X0P1G6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C002g01348 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C002g01348</name>
        <name evidence="7" type="ORF">BQ5605_C002G01348</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY32314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P1G6"/>
    <dbReference type="STRING" id="796604.A0A2X0P1G6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF134">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="28"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY32314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="461" mass="50202" checksum="01879583EB6C6DA2" modified="2018-09-12" version="1">MVVDPANPRSWTNRRKWLLSSSGIMFCAILSLSVSGRFRIVGETSYSISIGSVEDQMGVSKEMALLGVTLFTLTFGAAPLIIAPFSEVYGRSWIYFGSASIFTLFFLPQALAQNIETILVARFISGCAGSTAVSLVGGTLADVWSDEERGLPMAIFAWSAFSSTGLGPIMFGYVEENYDFRLIQWITMGASGLFTLALGCIVLTRETRASVLLSRKAARLRKETGDSKYQCKLDLEQGSFTHMMTTALSWPVKMLVTEPILISFSAYIAFCWAILYIQLVSLPLVFGELYDFSIGEAGMTYAAQFIGASVGLVVDHFCNKKYIKEVGRRGPEARLYSAMAGGTFVPVGCFSFTFTSFASIHWIVPCICVSVLYVGILLIYLAVFSYLADSYTLYASSALSAMSFARNLVGAVFPLFTDSLYDRLGIQGAGGLTSGLATLLSSNGTGREQSGQRLRDELQKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P3K8</accession>
    <name>A0A2X0P3K8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g02141 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g02141</name>
        <name evidence="2" type="ORF">BQ5605_C003G02141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P3K8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY39094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="170" mass="18865" checksum="D5F4E05849463D3D" modified="2018-09-12" version="1">MCCLSCLLPATRQRLPLPPAGEVGTAVWYMLQRRQILVKELHESRPTAFGLIGGVFAGRAKQVLRRSRGSPRHFGRRLSTLNNTQIHSLVTESSRRSSGPSAVDVRHTTIDLDAFRRELGLTPDPAAEHAERDRDDVSERRVEEVLGSRSEHEVEEEDDAELGEGDGESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P505</accession>
    <name>A0A2X0P505_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C004g03021 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C004g03021</name>
        <name evidence="3" type="ORF">BQ5605_C004G03021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY69487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P505"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY69487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="568" mass="61889" checksum="50896BC5F3E070DA" modified="2018-09-12" version="1">MSQQSNKTTINPFQASLDLVQAQVYHTHDNLNGFKIRAIVLLALNGGVIILSVAYLAVLEVQRRRVTPSPPQWLYQFVRRPPGDLLVMNARIISATLGIISSTCWIFIILDALNQYIEHRNPTIGGHFVRAFVMCPMFVHGWVASWFIYTTYILTNKSKSNHTSPLSVVSSATVNLFFAGLGLSALLGCIAIGVWQIGCVSNFWSRLHSLTNLLSQLATAYPNGISPTDSARAVSASAAFSSASDKWLHMIKWYFILLCIPASLVYVFSLTGLGLARHLGAHIELSKESLMRSLEQDPTGEEPTAAEPAETDLSTNHDPIRVFSPTNPTFKCASSPPPHSTFILPKNLSLDAEGLRFVAQSSSLHRKRAETLVLVSKARSELVVLSSFISANAVALIGLLIYSAYAVAKGQTIHGSWIATEVTTVGAAWISGISSCCATLGLIWNLWHYRTLSGGTPAAGLTSSSGGGEEMGATSQIDTLPRGTSVDPTMVHRHSGIEHPFQTFEKEREEPIEHYRGAIPASRSEARGGSDYSIWLALSKVRVVRDGTGESVREKISPWDFGTAELRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P5A9</accession>
    <name>A0A2X0P5A9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">leucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C001g00245</name>
        <name evidence="13" type="ORF">BQ5605_C001G00245</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2"/>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY45094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P5A9"/>
    <dbReference type="STRING" id="796604.A0A2X0P5A9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07959">
        <property type="entry name" value="Anticodon_Ia_Leu_AEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000001">
        <property type="entry name" value="Leucine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004493">
        <property type="entry name" value="Leu-tRNA-synth_Ia_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055416">
        <property type="entry name" value="RBD_LARS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00395">
        <property type="entry name" value="leuS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794:SF1">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24810">
        <property type="entry name" value="RBD_LARS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="10">
        <location>
            <begin position="60"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="10">
        <location>
            <begin position="216"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="11">
        <location>
            <begin position="836"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine--tRNA ligase RagD-binding" evidence="12">
        <location>
            <begin position="987"/>
            <end position="1050"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF24810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGY45094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1118" mass="124564" checksum="B52517EE996B0AE2" modified="2018-09-12" version="1">MSASTVAPPAANTSKRDYLIQLEHDAQKRWQHEKQFETDSPFTDGTLKVPEGTDVDFAKLAQNARKDRPKWMGTFPYPYMNGSLHLGHAFTISKIEFAAGFERMRGKRVLWPVGFHCTGMPIKSAADKIIREMEIFGPTFEGYKDPSTVDEADVEPPAPINGAPSAAVVSSDPSKAKKGKLAAKSTGLTYQFQIMRSIGVPLEEIQKFADPQYWLTYFPPIAQADITDLGGRVDWRRSFITTPANPYYDSFVRWQMNKLKALGYIKFGKRYTIFSPKDGQPCMDHDRQSGEGVGPQEYTALKMPVTTFGERAQRVKELAAGRKVVLVAATLRPETMYGQTSCFVGPTIEYGLYPSSSTKGSDEEVLYLVSRRAARNMAYQGLLKVEDSFDDATACVGKLQGAEMIGTKVAAPNAIHGEVYVLPMETVSATKGTAVVSCVPSDSPDDWITQLDLQKKAEYYKIDPAWASLEPVPVLSTPTYGDLTAKALVEKLRIQSPKDTKQLAEAKEIAYKEGFYQGTMVVGPFKGSKVEDAKTKVRDDMIERGLAFAYSEPENLVMSRSADECIVALCDQWYLDYGEPGWLKKAEKLLSRMNTYNSETRHSFERTLGWLRQWACARSYGLGSKLPWDPQFLVESLSDSTIYMAYYTIAHLLHGPPIDGSVVGPLGITAEQMTDEMWDYVYANGALPADAPIPTENLNILKAEFSYFYPMDIRSSGKDLIPNHLSFCIYVHSALFAEENWPLSMRANGHLMLNGEKMSKSTGNSLTLRDALLKFGADATRLTLADAGDSIEDANFEEATANAAILRLKTLTDWSEESIKLGENIRESSSEESIWDKIFANEINEAIELTLEAYEKSLHKEALKYGFYQLLAARDSYRDATAGEGGMRRDLIERFVRVQALLITPIAPHVAEHLWSKICGEKKSIQEAQWPEMTSPVDRIVLDSADYIRSTLKEIRDAELGFAKKKAKGKGTGSYDPSKPKAVKVWVAKGYPEWQDSAVALVREAFNDETNTVDEQKLRALLTEKGLAKDKKVNPFIAIFKKKIAQFGPEIAFNRQVLYDEKAVLDRAMAYVKRQLGMDKIDVVAIAEIKEDEPGMIAPIVEAAEPGKPGIVFYNVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P7J9</accession>
    <name>A0A2X0P7J9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab GDP dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C008g05024</name>
        <name evidence="4" type="ORF">BQ5605_C008G05024</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Rab GDI family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P7J9"/>
    <dbReference type="STRING" id="796604.A0A2X0P7J9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005093">
        <property type="term" value="F:Rab GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.405.10:FF:000001">
        <property type="entry name" value="Rab GDP dissociation inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000158">
        <property type="entry name" value="Rab GDP dissociation inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000806">
        <property type="entry name" value="RabGDI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF8">
        <property type="entry name" value="RAB GDP DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00892">
        <property type="entry name" value="RABGDI"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY79056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="452" mass="50923" checksum="67625479F7A3F21A" modified="2018-09-12" version="1">MDEEYDFIILGTGLTECVLSGLLSVEGHKVLHMDRNDYYGGESASLNLTQLYKRFRNADPTSDLGRDRDYAVDLIPKFMMANGEMVKMLVHTDVTRYLEFKQIAGSYVFRDGRISKVPSTEMEAVRSPLMGLFEKRRAKKFFEWVQNYRENDPATHQGVNLDQTPMSEVYSKFGLEVGTQDFIGHAMSLHLDDTYVDRPARETYERILLYTTSMARYGSSPYLHPQYGLGELPQGFARLSAIYGGTYMLDKKIDEVVYDDKGKFVGVTSGGETVKAKKVIGDPSYFSDPSGRGKGEDKIYLEGRVVRAICILKHPIPNTDNSDSVQLIIPQKQVNREHDIYIAEVSHNHMVCPQDIYIAIVSTIVETSDPEAELEPGLQLLGPIYDKFIEVAPIFSPASSGSYDGVFITRSYDSTSHFETVCDDVKDVWRRAIGSDLVLKKREDGEGIQEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P840</accession>
    <name>A0A2X0P840_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g03991 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g03991</name>
        <name evidence="2" type="ORF">BQ5605_C006G03991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY55232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P840"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAG-pre-integrase" evidence="1">
        <location>
            <begin position="122"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY55232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="224" mass="24480" checksum="493DBFF1F2894FFA" modified="2018-09-12" version="1">MPFNSLPAQVAYHCRFSTNSSLCRRLFIPHIGPLIIPCGSWSLPSGQVVHCNTYGMVRFKLKSGASLSLANVYHLPGAPVNLILTRALFKSGAKCGWEDGKDVMTITYQGVILAKTLSGTGYALDFTRIVEDQAHVATRATVGAPLMEWHCRYGHVPVSSIMELVKSGAVKGLVLTDEKVHNCEPCISSKSCALKFSELATQVTDILQRVFMDIGFVTEDQVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P8E5</accession>
    <name>A0A2X0P8E5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C008g05394 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C008g05394</name>
        <name evidence="2" type="ORF">BQ5605_C008G05394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY80466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P8E5"/>
    <dbReference type="STRING" id="796604.A0A2X0P8E5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051044">
        <property type="entry name" value="MAG_DAG_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11614">
        <property type="entry name" value="PHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="91"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY80466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="382" mass="42583" checksum="4C124FC941E6CFF2" modified="2018-09-12" version="1">MTWQPSPEEAWYYTLPCPSDDYSLSAWISTLRGQDRSYGRSSLPRAPFEQRLREEYTTRDGKISLGKGGIDKQWVCYQVWDPKQGTGNEKDLVLLHGINDYGGKFAMHAKKFLDEGYRVIVPDMPSHGRSSGLHCHLPHIELLADAVYLVLADVLLHDSKSLTPPNPSTSQTSSSTFTQSRKLFIAGQSMGGYAAVLTCLKYSSSTVSSLSPRPTVRYHPKISGGLFLCPMLEIVSTSRPSYALELIARALASIAGPLPFASANKGKNSEDPTIEIEFNADPQTYHGKLRIATGLSILKGMTHLSTLLSSLEVPFKIFHGTSDRVTCPSGSKKLFEQANSKDKELQLYEGYEHVLLRKGKDEKDDEKRQRVLGDMLEWLERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P8G6</accession>
    <name>A0A2X0P8G6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g04142 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g04142</name>
        <name evidence="2" type="ORF">BQ5605_C006G04142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY56521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P8G6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026960">
        <property type="entry name" value="RVT-Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13966">
        <property type="entry name" value="zf-RVT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase zinc-binding" evidence="1">
        <location>
            <begin position="154"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY56521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="382" mass="44083" checksum="3EDDC0F5BF383670" modified="2018-09-12" version="1">MDKVGDVCCKTILFALTSTPKVKAPSRDACAESSFNNVAGLDWQFAQIADLYCRDEGKGWALVGHRRGFWQHSKESALQHEHVWSRAPRPRCFNFFGLTRPFTIHKLRRLVNVVRFPGREDRVKRFRDGTSQSDRKRFWRWLHDRFASAVEQDTHWRLMYDVTPTRKRQHTQGHASSPTCLFCGNDAAVIETVSHYFFECAYSTSFWGGVLRILFDKLGINDTDVDPSTFTPEQLTMGLPLLRGRGRTTSKWMWVRLACAIGFQRLHLLRWRVHQRFELDKVVAPPSLPSTLRAFEREFLSRAGFVPGARDWEVPSNGSFVRVGQDLRHGSEGRSLVSGQYPRVKARLVSLYWIAFRSAPTAQQPALEIQPREDIRRCRGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PAC5</accession>
    <name>A0A2X0PAC5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C007g04792 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C007g04792</name>
        <name evidence="2" type="ORF">BQ5605_C007G04792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY63346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PAC5"/>
    <dbReference type="STRING" id="796604.A0A2X0PAC5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="662"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="709"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="745"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="455"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="709"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY63346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="765" mass="78967" checksum="37E63BFF3B2B1207" modified="2018-09-12" version="1">MSDPSGSSSWPAQRSQPGQDGSSLTPATSFQSSFSSFNLRQAPHRAAMHQGTSTTSQCNMASTSSLFEGPMNAASMDPTGMESTPSIAFPSTCTPPFTGGANSGAGSGSAGGISGAPPTPWTSPGSISTSPARPPSIVGGLSSTAQGSVPISNPHFRKNSTLGSCEPIYARASGPNSPSPSDSVFADDDDDAAVLRGMESDLDTTAGGMRHPQSSSRGDDSPSDSPMMIGSPTLNAIREISTEDSIPNFNRPNFQRANAPTESPHGRSRTPSLPSSVKHIPPSPAAIAKALSGQTEQKTPPPFLQRRLFGEDLNQMVIEGSRRSSSDGEASMAGVTNEMKLPTGPSNELNLMFRPHDSRSGSGSGEEGNTARAGVVRRAVSRKPNLLVSAQLHTNSRFYRSDLLTLPIYPRPPPQPKSKSHLRVLSEFRSESGPANLAEVLSEAALHRLSRSGASPITGSRSSISSLNASSFPLPSTESATSTGLANRFPEQIDDVDGAPSPPSSDGDDLALDEAGSDWGGTMSLGGYETEGEELEQRAKANLWTGFRNGNSSNPVTSTHSASSGSNNGGGLGGAALVTTHSGRSPGSGGMGEKKSMEMEAPQTPNWQSSARLGKRKLNDDRFEPYAIAFKRRAVSPAASSLSPSVASPLLSFTSSTTGLLGSTSSSHISTSTPPALASSSATFSAGSLPISIPSPTLGPTHMSYFGTRSRAASPVPSSLSSSAGRGTGTGMAAGGFLSFVGRLEREERNGGEKMGDEISRMSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PAN6</accession>
    <name>A0A2X0PAN6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="24">BQ5605_C035g11367 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">BQ5605_C035g11367</name>
        <name evidence="24" type="ORF">BQ5605_C035G11367</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000064">
        <property type="protein sequence ID" value="SGY96872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PAN6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0229">DNA integration</keyword>
    <keyword evidence="18" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="16" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="15" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="16" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="17" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="23">
        <location>
            <begin position="206"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="434"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="454"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="22">
        <location>
            <begin position="468"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="SGY96872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="744" mass="82535" checksum="43ABF29BA229BB63" modified="2018-09-12" version="1">MTYTFPYSRTMPRFPWIIDSGAKVHCVGDKSVLSDVVSEPLKISVADQSQIESPGHGSVTFLTSYGARITIKRVYYMPGAQCGFISIDRLLESMTYAVGPQSNLIFSIRGKSILRSLPGRGFVMDAAPVQPIMSSSPPSMVGANRLTGTCTLMEAHRKLGHQSPAAIVLAVKSGAITGITLKDEKVTPCFSCIQAKSKRSPFSNKSTEAPHALYRVFIDLGFVEHPNHHGDTIYLAIVDQYSTAKWTIVLKDKRAETIIKAWSKFQAESERQTGQKIKRVRSENGREFDNSLFRALLEKQGIIVEFTAPYTPEQNGQVERLNGSLMGLVRSMLLNSGLPMRFWSDALAVATFVLNLLLSKKPSLAHLQPFGSTAFVHVPKERRSKLAPRSIQGVFIGYSGEYNYRVWVQSSKQVYILCHVTFLETPSVITLSQDRADASDPVHHSQPPHPLPDVLPSTPTSPVVDPTLPDPQPPPVVPIGVGQQGGYLAVVPRKDDNNDDNNEPDDYHDAEEPLEGEAEVALAPREGYTIVRTGPNPGQFENVDPSNILPAGSCRQPQPPENILPIISAIMVDVLDTPPMFHDKLSYNAYCATVFAEEDIEIPKTFEEAMKSPYRNHWSAAMVSELLQFDHHGVFQEVKWHKGIRVLGTIWVYSIKRNANGKIIRFKARLVAQGFAQRPGNDYHDTYAPVARSSTILFLIALAAAQGLYLEQFDFDCAFLNGKMTKDVYVRYPKGWNRPQSPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PBW5</accession>
    <name>A0A2X0PBW5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C031g10906 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C031g10906</name>
        <name evidence="2" type="ORF">BQ5605_C031G10906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000068">
        <property type="protein sequence ID" value="SGZ05983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PBW5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="609"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="862"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="944"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="488"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ05983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1087" mass="116529" checksum="B6309A27BC274488" modified="2018-09-12" version="1">MLQDCSSKLLSMPPIGATIGHTTRRAFAADDTGSCRTTTQCDHELDSQLSPTRSRSPTASARARAHDIHLPLRDSSSSTTTMLPSRSASTGSNDLVELVRRLLRVPRSDAATQDEAHPLAVVLLLLECRLVQALAPCSQSTQSTEATTSHKLAIPVRDGTPDDGTNGEAANIVPSTQDTSQGPPPTAEARTVPLPRSTAPTAAVGAHSRADARAIQPDGHDTDRAPRPGWAQRTSYMNEVYMRRVQENDAWASPLYVPRHVAPSLVSAMSETGYNVRAQRLWQNSIDELEAYIITHFGFTCPSNALTATIPSTTDWVSDISALVAARRRSSLSLANPTSDVLCRLLSSSLAQLVSPECFGVSDGGARYAISEQDDQAIRRYFSGSTPGGIARSKPVSCATSYSPPADQTSRKVSQEKVSLAHYLPPGSSTTITPPRSTATGKKPRPMSVGSYGAESYTRSPSMMTSDSVQSSPFGHVRHNSRPSDTDSVLSNAPLLAAPSSPVAAASSPSQPKRSFSPKPRPLPVFIEDTAQDNLPSPAVPPFSSLIKASASHKAGSDPSSPSAVVASRTSCTLSPDERRHFIRQAKKLEHLLGKPVKESQAKEIVQAGTRNGATSLEGGNPDGRPSIQRKRSYSHPLVPTNVHQAEKNGGPSTQLWSLHVGGQDMRRANSSPNPSSPTLSPAPNQLLCVASPTSPGGVLSPLSPTTPTRAADATTMAFKNREQRRKKLAKLHRLLGEKVPIELALCKPGSVSSLDSIEAPGSKRNGTGAKSIWERAKGHVQAPWHIYTRQHDEAGLEQARRDEFIVDVEPDRHVLAVLTPEASAGVGPTTSTSTSTQAAELKYLATARKLEDRFGALPPKNLFQTANIKPPPRIDDRTSSHSRASKISLSTSVSSVDSYRTSIASLRFLMEQDPEALDQIAVALHEDDEGEDGVISIERDPPAIPQEARPLPHQHVKAPSLDSDRVSPSEESAFDDETRSTIRAPGTASPLASPTGSIAYPQKDPFHRTPSATMGSVRKVNKLLNFFGTLRGEVWNRLLDELQLAIEGDEEIEKEDETTLLLEVQKLRTFKPVDGRGGVVAITTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PDW3</accession>
    <name>A0A2X0PDW3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C008g04938 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C008g04938</name>
        <name evidence="1" type="ORF">BQ5605_C008G04938</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY78753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PDW3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY78753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="109" mass="12719" checksum="5DCED5DBA87733ED" modified="2018-09-12" version="1">MYARNLGIVMLVDNNHCLREKGWRTAARIRVSRKDTRRMDATGQELFFDREKDGLQRVQRVQRLMLGHNPKPSVLTASETLPGLLIPAFEEYAQLFHTMFPLTLSLWTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PEV2</accession>
    <name>A0A2X0PEV2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C023g09604 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C023g09604</name>
        <name evidence="1" type="ORF">BQ5605_C023G09604</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ23590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PEV2"/>
    <dbReference type="STRING" id="796604.A0A2X0PEV2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ23590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="169" mass="19149" checksum="8F2B7CC1E7671F52" modified="2018-09-12" version="1">MGNPFRGSRAPGARASFFARGSQESVPCGIWQLPIYTVDFSSARAIDRAPRFDGFWRVPPFRVGKVDFSSARAIDRAPRFDGFRLVPPFRVKKVDFSSARAIDRAPRFDGFWLVPPFRVEKVDFSSARAIDRALSIFIFTGNLGFYSKTYPGIGLYPTYDTYILQVRIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PEX0</accession>
    <name>A0A2X0PEX0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C009g05550 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C009g05550</name>
        <name evidence="4" type="ORF">BQ5605_C009G05550</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY82180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PEX0"/>
    <dbReference type="STRING" id="796604.A0A2X0PEX0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006798">
        <property type="term" value="P:polyphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050126">
        <property type="entry name" value="Ap4A_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42850">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42850:SF4">
        <property type="entry name" value="ZINC-DEPENDENT ENDOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="3">
        <location>
            <begin position="172"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="642"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="647"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY82180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="721" mass="78427" checksum="A86AF90D18244A60" modified="2018-09-12" version="1">MSRPHTDHHEDDDADKDPATALLLLPSLIPSPSSPRAIRRTLSTAIIILFFSVILYEAVLAPSGIDQEQVKGFGWTNYQSVYVGSHDLDSSDGSHTSAKTTTQKEQVETSSKTSQQTQQSVGTFSQLKANTVETMRKQGQLSSYAWHQVINNWNTSIVNAETAAMTTTGPGRLIIVGDVHGTHRSLASLLVSVAYTPTVDTLLHVGDIVSKASLASSLATVQFLRQHNVRGVRGNHDQGVIEWRNWMESYGELVPTSEGDVNAEEGKTMTEVSGHGVALGDDSLEESTPRARKRGWFGLGSSMAVEQETAEEKEEETQEIAKDKESTQIADLEEQGAEAIPGSTESDTPLSAPASFVSGDLLGHGYEWLILSQKQVENDFGVVVPNGWDWGGQWFEIARHLPKDDFEYLRSLPLTLRLEGLDLVLVHAGLVPAQSPHTPLSTYALTQAPATSLSSQSDLFFKPLFSVPTESIPSILQIEQNTLPFTMLNLRTLQLPKRGKGDYGVSKGKKHGTPWSEVWNEVMKACKESSAAYSSKEERDEEGSENVKKGCEPLNVIYGHWAGRGLDIHDYSIGLDSGCVYGKRLSAFVFPLSGAEEAGGAKEGKWRVIEEGFDSGARIGDAGQTVGSGRWRKLEKGFDSGVQHSARGRESLGVRQEKGPVSTAVEKLPEEGTAEATADADEGVKEASDEDDEVQEQDVEFLGRRGAKIVSVSCAKEVQKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PFB1</accession>
    <name>A0A2X0PFB1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C024g09796 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C024g09796</name>
        <name evidence="1" type="ORF">BQ5605_C024G09796</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ25898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PFB1"/>
    <dbReference type="STRING" id="796604.A0A2X0PFB1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ25898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="242" mass="24695" checksum="AD76F0158CD605CF" modified="2018-09-12" version="1">MFVPDSHLCWSFLASQYLTKRISAHLSYPIPPGRIFLGAQTTDASNQYSQNALLLLGYISPYSEGLHLDVDHPLGTNISLYNGANTFNLTLPTNLTTRISYVLVLGSTSNAGPPFAIRGTGPADPEASESASSTTGRMIEALPTTYILGGVTTVVNGPSTTTAAALTAASPTPAPGSTSAGATASPVVAIVSSSSSTAALTTLAAAAESNTMSRTSSAHHSTSVNTPLLASVLIGVGYFALC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PFV9</accession>
    <name>A0A2X0PFV9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="24">BQ5605_C038g11662 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">BQ5605_C038g11662</name>
        <name evidence="24" type="ORF">BQ5605_C038G11662</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000061">
        <property type="protein sequence ID" value="SGY91389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PFV9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="23">
        <location>
            <begin position="429"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="SGY91389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1099" mass="121316" checksum="33A58B37FB4B47F0" modified="2018-09-12" version="1">MDSSPASPLAPRDPSSPESLIGEQIATLQAQLTALQALQPAAAAATPAVTATASKVVFPKHARLDGPKSFTNWLRQLRLALPNQVRGYVLDGVIPPTWTADQLAARDDAAREIIVGSINSADVSATLDAIPSDDLSALRIFAALKARFAPDDATRTLELFARLWDFRKMPAFVEAYDTWLREYMSIAQEICDTKTSLNNVLATHVLAMVPSCLDSFRLTFTDKQQNRRDLPELTTLTDRMHAFVVNSGATTHMVADQSLFTTYRQMAHTKIGGIAGGITAIGMGDVAFVAKTGHPITLCGVLHVNLLSVSRLCDTDRVRLAFTSDGIDIAKDGQAIAHGTRVNDGLYLLDADHAKCQQLAFLSRCESTVALLTLHRCLGHLAPSSIQKMIAAGLLDGFGAGYSDKDVEEFVCNACLGSKGHRLPFPDSESHSPERLGLVHSDVLSFPTPSLTGKRYLVTFLDDHSRKLWAYAIDHKSDVFPTFQTWLADVELETNTRLRVLQTDNGGEYRSNAFTEFCKSKGIHRQYSIPYTPQQNGRAERVNLSIVEGVLALLADARLPATFWDEAAAYFVYCKNRCSHSALAKQTPEFVWNGQVTTATALHPFGCTAWLTVAPDLRSKLDPKAARVIFTGYDLASKAFRFFDHSINKIVLGRNATFLDDDFPGLPVTTPVDADDTDQQPSDDDCPDEIDFLSRHHRTFIATENDDPTLEAIEPVKSITSDPQTWREAMSSDERDIWAQAAAAEFTAMRDDFKVFTIKPRSALPPGATIVTSKFVWKTKRDARGDVTGRKARLVAQGNRQRDGIDFSETFAPVARFSSIRCLLALAAANGYHVHQADIDKAYLHGELDHDIWMTTPRGFDFPSDKVLRLRRSIYGLKQAGHIWNRHIDTSLRNLGYKATGTDHCIYSRIDDQQRPHYIALYVDDLLIVSPGLDEIELVISGLEQRYSVKQLGPAEYILGIQIRRLDDGSIALSQERYIMDVLARFHFDTTTRGTTVPMTPGLSLTAIPGRGTERIRSWYLQAIGSLSHVGTANMVADVFTKALGPKIFGTHCYALGLRTRHPRLKSTLRSRGCVCVCVCEESTLRSTQDLGARSKPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PFW4</accession>
    <name>A0A2X0PFW4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C025g10037 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C025g10037</name>
        <name evidence="9" type="ORF">BQ5605_C025G10037</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000087">
        <property type="protein sequence ID" value="SGZ27047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PFW4"/>
    <dbReference type="STRING" id="796604.A0A2X0PFW4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000044">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000030">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="204"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="50"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGZ27047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="315" mass="34677" checksum="B736602D52E3DC7E" modified="2018-09-12" version="1">MPSLFPALPHATHPHQQASSSPHHAAPTHASTTATAAKHRGVSSYFINKIETAELLINSKTQNLRRLEAQRNTLNARVRLLREELQLLQEPGSYVGEVVKVMGKKKVLVKVQPEGKYVVDFAPSIQLSQLTPNLRVALRSDSYQLHTILPTKQDPLVALMMVEKVPDSTYEMVGGLDQQIKEIKEVIELPVKHPELFDALGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCKFIRVSGSELVQKYIGEGSRMVRELFVMAREHAPSIIFMDEIDSIGSSRGESGSGGGDSEVQRTMLELLNQLDGFEATKNIKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PIL1</accession>
    <name>A0A2X0PIL1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Replication factor C subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C031g10940</name>
        <name evidence="9" type="ORF">BQ5605_C031G10940</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000068">
        <property type="protein sequence ID" value="SGZ06415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PIL1"/>
    <dbReference type="STRING" id="796604.A0A2X0PIL1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000028">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000004">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF9">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Replication factor C C-terminal" evidence="8">
        <location>
            <begin position="113"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGZ06415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="210" mass="23572" checksum="DBEC8C74A140AFAA" modified="2018-09-12" version="1">MTSAAQSALRRVIEQYTKNVRFCIICNYVNKIIPAVQSRCTRFRFGPLPRPEVEKRLNHVVDAEKVNLTEDGRQALLKLSKGDMRRALNVLQACHAAYDVTDEAAVYNCTGNPDPADIEAIMQSMMNESFETSYRRISSLKMEKGLALQDIIQGCFDFVATVEFPRQTRVVLLDHLAQVEHRLSTGASEKLQLTALLGATKLAIELSQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PLV4</accession>
    <name>A0A2X0PLV4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C023g09758 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C023g09758</name>
        <name evidence="3" type="ORF">BQ5605_C023G09758</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ25008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PLV4"/>
    <dbReference type="STRING" id="796604.A0A2X0PLV4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ25008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="97" mass="10778" checksum="08C5AC8F77552E61" modified="2018-09-12" version="1">MKKFVKEGSFTGTKEEEMGKRTKSVEWPVEVRYSFWEIPGAFSFGLPILALLVLTGLWKGWFSGGRHGELLDKVSRPCCAEAAKKALEAKKALSGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PQE7</accession>
    <name>A0A2X0PQE7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">BQ5605_C079g12960 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">BQ5605_C079g12960</name>
        <name evidence="18" type="ORF">BQ5605_C079G12960</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000120">
        <property type="protein sequence ID" value="SGZ34054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PQE7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="17">
        <location>
            <begin position="117"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="401"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="954"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="401"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="SGZ34054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="989" mass="109047" checksum="158F32AF33EEA198" modified="2018-09-12" version="1">MRLARSMDSSLSVARLCDTDRVRLAFTSDGIDIARDGQAIAHGTRQLAFLSRSESTVPLITLHRCLGHLAPSSIQKMIAAGLLDGFGAGYSDKDVEEFVCNACLGSKGHRLPFPDSESHSPERLGLVHSDVLSFPTPSLTGKRYLVTFLDDHSRKLWAYAIDHKSDVFPIFQTWLAEVELATNARLRILRTDNGGEYRSNAFTEFCKSKGIRRQYSIPYTPQQNGRAERVNLSIVEGVLALLADARLPATFWDEAAAYFVYCKNRCSHSALAKQTPEFVWNGQRTTATALHPFGCTAWLTVAPDLRSKLDPKAARVIFTGYDLASKAFRFFDHSINKIVLGRNATFLDNDFPGLPVTTPVDADDTDRQTPLVRSAHMDVSSSLDDSAMSAVDVAPGYTGGSLLNSTDTRSSSSPSLSPFSSPATSSARDPSLNDSDDPLDLLSSNTAVRLNLLDVHRSDDDTPETQAPAIDFLSRHHRAFIATDDDDPTLDAIEPVKSITSDPQTWREAMSSDEHNIWAEAAAEFTAMRDDFKVFTIEPRSSVPPGATIVTSKFVWKTKRNAAKPSHPSPASPPFAASWLLPANGYHVHQADIDKAYLHGELDHDIWMTTPRGFDFPSDKVLRLRRSIYGLKQAGRIWNRHIDTSLRNLGYKATGTDHCIYSRIDDQQRPHYIALYVDDLLIVSPHLDEIERVICGLEQRYGVKRLGPAEYILGIQIRRLDDGSIALSQERYIMDVLARFHFDTTTRGTTVPMTPGLSLTAIPGQGTERIRSWYLQAIGSLLYISLGTRPDIAFAVSYLSRFANNPGRRHWIAVKHVLRYLRATYRDELLYARGPAKVTGVVGYSDANWGACVDTSISTMGYRQTRVADSTTDAEYLALSHAGKESHDNEAAAAVAHDPVRTSGTRHIRLREHFVRDMVNRGDISLSHVGTADMVADVFTKALGPRFLESTLRSAQDLGARSEPGADLGARSEPGAPAQDLGAQSEAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LPT3</accession>
    <name>A0A2X0LPT3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C011g06666 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">BQ5605_C011g06669 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C011g06666</name>
        <name evidence="4" type="synonym">BQ5605_C011g06669</name>
        <name evidence="3" type="ORF">BQ5605_C011G06666</name>
        <name evidence="4" type="ORF">BQ5605_C011G06669</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LPT3"/>
    <dbReference type="STRING" id="796604.A0A2X0LPT3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.20">
        <property type="entry name" value="Centromere DNA-binding protein complex CBF3 subunit, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038279">
        <property type="entry name" value="Ndc10_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031872">
        <property type="entry name" value="NDC10_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16787">
        <property type="entry name" value="NDC10_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ndc10" evidence="2">
        <location>
            <begin position="233"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Ndc10" evidence="2">
        <location>
            <begin position="333"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY12962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY12969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="614" mass="68489" checksum="E01953399CAC0B37" modified="2018-09-12" version="1">MTLNSSPIRGSARTAHSVPVTDSNADRRDEFECREDDGEHAESEREASEGEGNEQDMGIQASNNAIIASCTSTSNLAPKTVSAYEKSLKSYTKFMAETWPGACVRPIDPDMVLNFLSSESKRPARRSGTGADQGEDIEGTTIGVSVFKNHLNALEHYRVIDSIDRTSVAARGKLRDFPPIGNLEAGWKKREAGRKKSAQTNKIEGTASDNVTKEEQLQISEHLLCQGPTVSLATLFRGDNTRALAFSDLSMRALERPDHPPIKTLYIVADSGKTNKEGRLDYKPVARHFDPRICNVGAVAFYMWFRDEHTGGLPYGKSWQLARLAEIGHNVAVSTFLKECDVHSSHTTHLSRIAGAQMSAERGANEADTKALGGWSDGTFRSVYQRGDPTTSFIALVGFNGKFPERYYVARDIEADVPDDLQRLIFPWVEAALAEFEERFEADELCQDKALVDHLKLLQWFRLVILQDAAFLISAYPDAPIFQATLFQSDRFRTWASHFVASVEGNGREETALKVVYGGLLDSIIDRLGAQQSSERQSATAHLRSDNHRILELLIEQQNQGGHFHGHVRKRRRPEYVRDFDDFDDDSDDDRRDLSNAHMSAPTSTYLLRSACIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LS06</accession>
    <name>A0A2X0LS06_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C011g06281 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C011g06281</name>
        <name evidence="2" type="ORF">BQ5605_C011G06281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY11819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LS06"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY11819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="123" mass="14645" checksum="97CE98932FF3B26B" modified="2018-09-12" version="1">MSTLEMFLHRQLVILHVGRIDFVQLRIRMDNSRNTDSCTTSRRSEGQQQHFQWERPERKRSEDLGHNNCGDSGKGSKMSLSINHLHPSQRPKSTLSRWMLQHSHRLHCVHCPRINFVQWIHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LSB2</accession>
    <name>A0A2X0LSB2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C011g06391 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C011g06391</name>
        <name evidence="2" type="ORF">BQ5605_C011G06391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LSB2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY12109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="112" mass="12375" checksum="A2D4AD556CDFFC14" modified="2018-09-12" version="1">MAEEVVVEEPVLRKLAKRSNPYRPRQQRFGLLHDDRKPTCTVPDHSIGQASGGSIHRPRNPGGSGKVQSFDSATVAAGGGHQVKECTEPARHWHRAAIAQRRYAPSIFLPCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LSY8</accession>
    <name>A0A2X0LSY8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C011g06312</name>
        <name evidence="3" type="ORF">BQ5605_C011G06312</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY11901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LSY8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="142"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY11901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="310" mass="34685" checksum="797DDCB082A71BE3" modified="2018-09-12" version="1">MSPVQTEAQASPSFSLLLFTPYPSPPRACNIRSGRCGSTATNAGYRNACRMQHSYEFEDSLQHVLFECQPSSCFFTVSCGRIDFVRLRIRVVKNRLWSRELRLTIPWQILNVLVRWGDHRVGSNAFPSPSTARFGGVTVVLAGKTFLGETVLAQIRSKETYALAVASSGIAALLLPKGSTAHSRFKIPIDIFDDSTCNVPKQEQLAELWDEALMQHHRCFGTLHVESSKMSRLITSTTWCSTCCRVTLKPSTARIWTPSLRWMSPQSPIALRPLPEDQLHPMDLPPVNAAISRRSQGQQRLRIDESSVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LTA7</accession>
    <name>A0A2X0LTA7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">BQ5605_C015g07970 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C015g07970</name>
        <name evidence="14" type="ORF">BQ5605_C015G07970</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acid sphingomyelinase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY18076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LTA7"/>
    <dbReference type="STRING" id="796604.A0A2X0LTA7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045473">
        <property type="entry name" value="ASM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041805">
        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF34">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19272">
        <property type="entry name" value="ASMase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="12">
        <location>
            <begin position="347"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingomyelin phosphodiesterase C-terminal" evidence="13">
        <location>
            <begin position="656"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="145"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="799"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="889"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF19272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGY18076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="909" mass="100288" checksum="80E3A26B35B77ACB" modified="2018-09-12" version="1">MRSSAQDAPTASTTATASSSYTRRANFAAAVARASRQAAATHGVDGNSPRGQPIPSPNRSKSKSNHTATPPPSTPSTPSTSSTPSTPSTPSTVAHPETTPLLQSHASSSTSHYSSTPKRPSPLSHQLTATTLASSTSSLATLSTTLPNYGTLSPPTSGVSSPNRSSRRPSGVRHGESGSSLPSPGDTKPSKAGQIRSRLLFVLIALLLTICVYASFVDDFMGDVEAAISCGACIGLLVPLQALAHVGDDAFVDFFVGFCSKLRIEDEDVCAGAIGTQAPILAHDLRSISLASHAAKNFCSTVFGLCPLQRTIPYSVQFLDGSQGNDDTRRLMERPRKVWKSKGRDPLKVVHLSDVHIDRNYLEGADTICSKVICCRDYGERSLGPNISHPAGKCDAPPDLMESMFRAIDRFVPDRAFTIFTGDVVESAVWTVNKPKVTSDLEAWHKDMVRNPATPSYPVIGNHDVAPVNAFPRTTSWNRESENSTTSPEMPSTLAIARTASDWVFELAARDWEKWIGPRASRQVREHYGCYSRVHPGTQLRIISLNTNYWYKQNFWLYDHDQPLWDPNGILTWLSHELHAAEKAGQRAWIIGHMPFGKVDALRDQSNYASQIFDRYHDTIAAHFYGHSHVDEFEISYPDYGDRRAETAHGIAYISGALTPASGNPVFRLYHVDPDTYEVLDFIPYYTNKSERSFQIDPVWKPYYSARESYGTILEENGFGDLRPKEGESLSGKFWHRVTEVFEKNETAFQIFTNRLSRGGKIEDCSGPICKNNTICMLRSMRSESNCAVIQPGLSFKDQKRDTEAVTEPQRGEGEEEFAQSRQHDFFACEGPGLGSMLRKIAQGGFDMSKVDRKERGKMMGMQAFGEGGDRTGRLGVFEGMLKERVEVERRKKKRGKTSGLLSRFKRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LU02</accession>
    <name>A0A2X0LU02_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C010g05829 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">BQ5605_C108g13199 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">BQ5605_C124g13322 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C010g05829</name>
        <name evidence="3" type="synonym">BQ5605_C108g13199</name>
        <name evidence="2" type="synonym">BQ5605_C124g13322</name>
        <name evidence="1" type="ORF">BQ5605_C010G05829</name>
        <name evidence="3" type="ORF">BQ5605_C108G13199</name>
        <name evidence="2" type="ORF">BQ5605_C124G13322</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000024">
        <property type="protein sequence ID" value="SGY27538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000071">
        <property type="protein sequence ID" value="SGZ10319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LU02"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY13311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY27538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ10319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="53" mass="5941" checksum="1A81185D46198C99" modified="2018-09-12" version="1">MVRSFALVKIYGMAREGRSLVSGQYPRVKARLVSLYWIAFLSAPTAQQPALEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LU07</accession>
    <name>A0A2X0LU07_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C014g07458 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C014g07458</name>
        <name evidence="2" type="ORF">BQ5605_C014G07458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY18747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LU07"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY18747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="100" mass="10960" checksum="C97DD153C9EB8232" modified="2018-09-12" version="1">MEHEDGDDKLAVASRRQRFGKTGEVDRLSSGMETAARERELNRLARAKGGGGEQSKQATAGRMDQDVDVLTKAHMGRVVASMAEQAKLATTGRLTKMWTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LVK0</accession>
    <name>A0A2X0LVK0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C016g08225 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C016g08225</name>
        <name evidence="1" type="ORF">BQ5605_C016G08225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY21346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LVK0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY21346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="66" mass="7732" checksum="EF3E5EF94FB1C17F" modified="2018-09-12" version="1">MVPFPFQCLRWHTREGFGSLWNVGLPLFWVDAWTALCHALELSMVWSEGRSRGGAHFLFVFPLEFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LYX6</accession>
    <name>A0A2X0LYX6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C017g08516 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C017g08516</name>
        <name evidence="1" type="ORF">BQ5605_C017G08516</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY20187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LYX6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY20187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="76" mass="8362" checksum="6C250DF9004D2454" modified="2018-09-12" version="1">MDQTRSSAAPVVALAARAQKSSMSPTQTWIRGTCEETAKKFDVSEEDCVQVSVVRDSCRISGTKYPCRFGRSMTQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZD4</accession>
    <name>A0A2X0LZD4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C016g08154 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C016g08154</name>
        <name evidence="2" type="ORF">BQ5605_C016G08154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY20844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LZD4"/>
    <dbReference type="STRING" id="796604.A0A2X0LZD4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY20844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="152" mass="16661" checksum="CB21C8F68AC2EDEE" modified="2018-09-12" version="1">MYIAKEKGRPMQRRVCEAAPARHSAALGLSSSYSTAGLQDRVGASGAASDSEEENDDVFRTSETGPSLDPSKGLESQDEDQEEEEGEDGNEDDEEYVVSVGKRMKVKEVAMQAPGSRERKKPKLEGTSTQVRFEWLDIYVRVPADGDSIPCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M0E8</accession>
    <name>A0A2X0M0E8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C018g08588 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C018g08588</name>
        <name evidence="2" type="ORF">BQ5605_C018G08588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY25165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M0E8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY25165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="162" mass="18272" checksum="889DB9811DFD33EB" modified="2018-09-12" version="1">MYFPSARSSGLGRASNLQNKTQLEREPKSKNISLQGLAHEVELYAEPPSDHPLSHSSGYCRAVLPAVGTFGKTLGPAFAFETRFGPVKVFLHLEFLRTSKFIFVHQCKCIRSLVATYGGHHREKHPAKMEFRSNMEHSVEPFARRPATSHSTRVRRHCHSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M2F4</accession>
    <name>A0A2X0M2F4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01392 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01392</name>
        <name evidence="2" type="ORF">BQ5605_C002G01392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY32646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M2F4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY32646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="443" mass="49424" checksum="952751EA2A69D1FE" modified="2018-09-12" version="1">MARGRRKKWTPKAHAPPPISEREARLQSRRTRLQVLDLPGAAASPPAFSAPFPLEPTHIHESSSTPHWKSSLEDVFEDVEPAGSSQRGFSDDVDATHSHSPVRLRRSTNEVELSPGSEKKLYEPQIRQRVDYSSLQSRRSMTSLQGDNPKSLEPPVPESRPRGETSDYGTVAGSAGADPEERDDTLDHARMDSKVFCAELVQTARVRDSPSSHQFSVAASICSSEESNTHDDLLGHDDSVLNMEGERVFNAQLRYRLTQSSNLPSEIPLGKIDLDFDDVTSSETERLSPRPFKSILLVHRCEVPTIWPSPSKSRSDTCGVTAYEYNGDLFLSLRNVFAGARKMCLWRGPLQWHQFDGLNPMGSIAHLATELVPDLRATASYSWWAMEDLAGIDDYRPRAICCANRYEVMGLELGVVEEGAQAGRQTFKKFREAGSARKYQIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M376</accession>
    <name>A0A2X0M376_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BQ5605_C002g01712 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C002g01712</name>
        <name evidence="11" type="ORF">BQ5605_C002G01712</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY34988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M376"/>
    <dbReference type="STRING" id="796604.A0A2X0M376"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004773">
        <property type="entry name" value="K/Na_transp_Trk1/HKT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00934">
        <property type="entry name" value="2a38euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF30">
        <property type="entry name" value="HIGH-AFFINITY POTASSIUM TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="654"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="687"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="725"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="786"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="826"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="913"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="944"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="312"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="418"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1014"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="342"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1016"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1057"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1087"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1110"/>
            <end position="1123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY34988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1123" mass="124584" checksum="1838C6664B5D329A" modified="2018-09-12" version="1">MRSKIGDFPGFYLRASGWALMGPWAGQWQGDRLGPTPSPALVASLFPRNTLPDGEPTRTFSAPFVQPRSKRGSACSFGQGRVCRPSSVALTGHTSGCSGSGSNPTAVRAMVKQSRSLSLARHPSTAPHVPSLFRKSASLSGLSEWMSRHLNFYRHLATLVLLHLDARVVPCCAMNSRPWRSHRVRSVHMLFFLFMPLVSSGIFYASNGATKVAYIDALFMTVSASTVTGLNSALLGPMTRWQQTIINMCVGSTVFVSLVTIVIRLSFFRRKFEYMVEHDPAARQRVNRVGAEEAQLEGRSFRPFPTHLRASDIEFATHSPAGSSPIWTREEKKEGDANNNNNKKKKKKKKKKKKGPLRTDMITRVDVPVRVNQMNVTGWLSDEAKAAEELATTTQAGGTIKAGEFGGVITAEPEAAEEPVASSAPHTTAIHIDDSTKPDRSHRHVRRTSDPIAHAPASLSPTHQSVGLPRVKTLDTHHAHDHRHGSLTSPASPDFPRSRTIEFRDNGDSNLRMRRTRTGAQDVDVRRRQSQGNLRDIEAHTLTRTGTNAPDALNTGFGGFPNPIVVAADYARKRIPVFNTVVERNSTLPPTQTLASVHLGLGPPTDTQNLKPVSYISFDAVVGRNSKFRGLTSAQQEELGGVEYRALQLLLRIVFAYWIGLQLIAVLVLAPWLTYSERYRPVLEDPQWAVSPTWFVFFQVWSAFSNNGMSLVDASMVPFQQAYPLIVVMSILILGGNTAYPVFLRICIWIIFKLVPRRSRTRETLQFLLDHPRRCYIYLFPSHQTWFLVFVLVILNSIDWISFIVLDIGNTEIERLPVGIRIIDGLLQAFAVRAAGFAIVTLSAVAPALQLLYVVMMYVAVYPIAVSIRSTNVYEEKSMGVFEEEEDEDDVEARFEKSHSASQYISYHARKQLAFDMWWLVLAVWLICIIERRLIGDLEYPEVTIFTIMFEVASAYGTVGLSLGTSRKNTSLSGILRTLSKLVLCAVMFRGRHRGLPVAIDRSILLPSEIKTAETGSTRGDGASARRGSRSSCASSGRDEDGPGGEGGLETVEPETDEARTERVRHESGRENSGDEAYGFEYTKPPTEPRSRREDESSELAHKSDFNEGVVSNDSDNTISETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M3B3</accession>
    <name>A0A2X0M3B3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome b-c1 complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Complex III subunit 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C001g00433</name>
        <name evidence="12" type="ORF">BQ5605_C001G00433</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with cytochrome c oxidase (complex IV, CIV).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UQCRQ/QCR8 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY46434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M3B3"/>
    <dbReference type="STRING" id="796604.A0A2X0M3B3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.210">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004205">
        <property type="entry name" value="Cyt_bc1_su8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036642">
        <property type="entry name" value="Cyt_bc1_su8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12119:SF2">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12119">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX UBIQUINONE-BINDING PROTEIN QP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02939">
        <property type="entry name" value="UcrQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81508">
        <property type="entry name" value="Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY46434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="100" mass="10993" checksum="9F1B9F62DC1926BC" modified="2018-09-12" version="1">MIPTSAVRSGMPSGKTYMGWWGDMGGPKQKGVTQYSVSPMRQASMRGAFSHWAVNGYRRIMGQAVYFVLPLGAGYGLLKWAIADNHLRNSKEGHIQGKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M410</accession>
    <name>A0A2X0M410_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C001g00670 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C001g00670</name>
        <name evidence="9" type="ORF">BQ5605_C001G00670</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY48607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M410"/>
    <dbReference type="STRING" id="796604.A0A2X0M410"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF21">
        <property type="entry name" value="MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="184"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY48607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="397" mass="43651" checksum="87C0FA82C584BDD1" modified="2018-09-12" version="1">MPILRRPMRRSLVHELQTRGSLYLGLLHFSVLRRVRTPVLLFTLYAGAIHVLLQWYEMPRFTSGASSVVATLNLVLALLVSFRSSSSYDRWYEGRRQWASLQSTSRTILRLFYFSLPPPAASPTGSAIMVQQHSKVVNELCALVCAFAYATMYHLRDEPGVDHPELQRLIPPSLLRAYKETPRQLRRDPSIDGSNDHHSTASETTRALEGLNTAPYPTDALPFALLSGAPSNLPLSLIRAIHGYLNAFHATPLASAGSPNPQTPAVDGPTYANGLSAIRDFSDQLTALERIRDTPIPLVLEIQLQFLLLVYVAAVPLQCAKLGIWSIPVTAVAAAVFYGVDRAAEELSDPFGIEPNDLPLAKLCAGIHREYIELVGAGTLSGSYGNEWVPSLSRKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M4W0</accession>
    <name>A0A2X0M4W0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deoxycytidylate deaminase</fullName>
            <ecNumber evidence="7">3.5.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">dCMP deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C001g00963</name>
        <name evidence="12" type="ORF">BQ5605_C001G00963</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.12" evidence="7"/>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY51106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M4W0"/>
    <dbReference type="STRING" id="796604.A0A2X0M4W0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01286">
        <property type="entry name" value="deoxycytidylate_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000035">
        <property type="entry name" value="dCMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035105">
        <property type="entry name" value="Deoxycytidylate_deaminase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086:SF18">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="11">
        <location>
            <begin position="243"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY51106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="416" mass="45157" checksum="6BC99226EB0CE93A" modified="2018-09-12" version="1">MLIILIGASQSGKNTLAQHLIDTHSYTRVHLPRDPTKSSSESSSDFTSNSDLHFDSSTEFLDYATRYWKVDYVTTDLRNAVKLHEFSKRPFVAIVAVEAPLSVRYSRTKKSSRSREDGSLLNSGSLESFVESDDISTYGALPASTTPNTSAHARTALVVAQALDWISSTPPPTHLSSADAPPSPSPSPRRAAAPLQYSHEDRPDPLIDLLPLANLTIQNPYSDPAPFFRALSLPKLQEALRPSWDPYFMLLASLASLRSNCMKRRVGAVLVREKRVVSTGYNGTPRGMRNCNDGGCGRCNSGSSGRVLATNADHDTANSTSLTSIRMGEGLDECLCLHAEENALLEAGRERVSGGGTEGATLYCNTCPCLRCTVKIVQCGVIEVVYSLSYSMDAASRRVLEEAGVGLRQIKLPVFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M5N9</accession>
    <name>A0A2X0M5N9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">DNA damage-binding protein CMR1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C003g02433</name>
        <name evidence="7" type="ORF">BQ5605_C003G02433</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">DNA-binding protein that binds to both single- and double-stranded DNA. Binds preferentially to UV-damaged DNA. May be involved in DNA-metabolic processes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the WD repeat DDB2/WDR76 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY40861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M5N9"/>
    <dbReference type="STRING" id="796604.A0A2X0M5N9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000001">
        <property type="term" value="P:regulation of DNA damage checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050853">
        <property type="entry name" value="WD_repeat_DNA-damage-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14773">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14773:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="17"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="133"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY40861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="554" mass="61532" checksum="41A52D7E83EDB5A1" modified="2018-09-12" version="1">MIACQPITDALKALDFNPPAVSKPSSTASTATTKTKSTVPRKRPAPKRELPSREPTRARSTRMAAAAGQQRTDEEIQAIAEANAKEEEEEKERLRVAKHGSRSLDAMTGVTGSLETEQLQEEFRRLANYVAETTNRSASSAKSSPSKTRRAPSSSPQKGGGATELGPANVDTKALQTIVKSVEHRATVKIIPDRIYSMVVHPDQTRDLVFAGDKKGHIGLWDATNAGNLILAASNGSIRDGAKNDIEDEEDEEEVFTPDRGNHYHWQGHLQNTVSQLKLAPNDPHKLYSSSYDCTLRCRDFTKDVDYEIVDLDRFDESEALVHSFDFTPSGHVLYAVDNNGGMVRRDLRQKMDKAERWYIDRAKVGCISINPANENMAVTAHLKKEMKLWDLRKFTTSAQETSAEDQMEDALLASYSYRNACSSAYFDWTGTKILSTCYDDYLRIWDIDPKKTEPVVKTFEPSTKIRHDCQVGRYVSVFRAQWIHSPLLPSSFTIGNMKRYLDVYSADGTNVAHLADEMITAVPAVTAAHPTLGEVRLYGGSASGKISFFKGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M5V4</accession>
    <name>A0A2X0M5V4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g04066 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g04066</name>
        <name evidence="2" type="ORF">BQ5605_C006G04066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY55717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M5V4"/>
    <dbReference type="STRING" id="796604.A0A2X0M5V4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.20">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019400">
        <property type="entry name" value="Peptidase_C65_otubain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042467">
        <property type="entry name" value="Peptidase_C65_otubain_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931:SF15">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTUBAIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931">
        <property type="entry name" value="UBIQUITIN THIOLESTERASE PROTEIN OTUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10275">
        <property type="entry name" value="Peptidase_C65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY55717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="161" mass="17325" checksum="D556F446C2FB76B0" modified="2018-09-12" version="1">MSPDPPAAGSGVSVADQPVASTSTSSSSSSAPVAPPPAPQPTEDSHPIPLSKCQLSDLTDLEIASLTQQIKAESANVRPLIGALEPLERFKDEYDSERVRGKIEWLSKSGWTGLRRSRGDGDCFYRSFAFSFLERLVPLPPSFTQLSLSKIESLLPLLDQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M5X9</accession>
    <name>A0A2X0M5X9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C003g02422 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C003g02422</name>
        <name evidence="7" type="ORF">BQ5605_C003G02422</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY40789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M5X9"/>
    <dbReference type="STRING" id="796604.A0A2X0M5X9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022043">
        <property type="entry name" value="CAF1A_DD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15272:SF0">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15272">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A CAF-1 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12253">
        <property type="entry name" value="CAF1A_dimeriz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromatin assembly factor 1 subunit A dimerization" evidence="6">
        <location>
            <begin position="685"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="453"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="727"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="886"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="29"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="453"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="477"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="727"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="747"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="906"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY40789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1010" mass="110347" checksum="574BBC10F9A67FF4" modified="2018-09-12" version="1">MSASSSLLDTPKALTTKSIPTTTERLGFPSSCSSSSRCASSPSSRDGCSSSSPSSPSSAASTLASSVIQSSKRRHIDMDSISLHDSSSSPPPRSPLGEDVEMEVDVQVLEDTSNNEPSSLSKRKLAHQTQQQDSIIKKPKLLAEHVTPMSTPSKTASSENVHLASASSVVKSTTTNPKLNTTGPAASPAPLEPSLVDWVKGKFVVKQKPFEATKIPSAIERWTAFTTEFAQKFHSDPEFELTEYPQQHHAVFAAMINESTKTLIALSKSIRDELVKALDGAILGLAIQADLDDEDDDDDDRKVESKSVLERIPLGPIKSLVAELAERVNHGLDVGSLLVSGGGQEDEHKMDQDKISSDIIGSSNPLVVPQGLQLWFWELNSMSLLPTELQARLTKRRNQRFEMGKACLRIWQALGEEERKGLLLEGNGSAGKTGEVGTSTVKEPKGKVAKTVAVASSSMANSEASGSGSATRKKKVKTDEQLREIEEKRRKKEEEENEKAEKKAAREKVAAEKAAEKAVKDAKKAEKLAAEEKKRKSLSKSAGFMNAFVVKKTPSPAASNDASSNSAGQRVKESDFNLVFKDFNDARAGVEVAPINRFKKYRLATKGKLPEVRIDSEPTLSKQTALADLTKGVPARRIPTYHSALPKTTVSVRSIAEEVTQCAVTGGDPAPLLKILQDRRKVPVKLLKFHDDVRPGYVGTWTIWSRTIRPRAPLEVDRALINYEYDSEADWEEEDEDAEDLRSGDELSGEDNSDDDLSDDWLAGDDDVEYLDGAGSEDELRMDADGGAEDLELLATRRRLERREKKGKARNKKEIKTLIPIVKGPCWETRLGVPKEKMFESMRIQFLNGQLRRCFMATRNLLLTVSDVSLADAHVGIDPFRWESKPLPPPTNGMAAKGKGKAVADPTNTDMSAPGQTGGKKKAGRFSTIMSDGDVARMISLIHGSEMMSKIKLLEGVVEKLNRSSVFKVPKLTVQAKWGELDPKKVESATIKGKKVWDVDQVIRAKYGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M6D3</accession>
    <name>A0A2X0M6D3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g02582 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">BQ5605_C033g11242 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g02582</name>
        <name evidence="3" type="synonym">BQ5605_C033g11242</name>
        <name evidence="2" type="ORF">BQ5605_C003G02582</name>
        <name evidence="3" type="ORF">BQ5605_C033G11242</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY41887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000066">
        <property type="protein sequence ID" value="SGZ03017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M6D3"/>
    <dbReference type="STRING" id="796604.A0A2X0M6D3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY41887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ03017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="761" mass="82762" checksum="70839C332E7404A1" modified="2018-09-12" version="1">MASSNETTPIVSSNSRPPTLTRLFATCAPSSWFLPPPHHDGVCHSTATRVQAEAGTTAYDCVARLGGLKWDSPASPGARVLGSFFDILEQHPSLLDLFREELDTINNAPRSRMPRKSEHEVEISFHRLLFGGLESATAALLNHYAAITEAVGASSASASTSATRPRYSVQLGEPQRALRTQGDAVVYIELEAGNVVSSISIEYKRDNVHHSLAKVRQEGLSHIPILDHGAPVPLQKLEEEESKGADAVATKAIIQCVSSKSRFFLLLSVPFFQIGELVQHQSTHAATASDPVASTSAASASISAATAYSPAPPLKARYSLILQELARWVEPSPTTLNPNAAETLGADLPRRSLIVSFIALAFTAVIEVPKPDQAVIDTLLNPQFQPPNLPRRRSDPDLDPNYEPSPRVQKASKTSIEATGARRSGRLVGQPPRAQTKDSNRPVTPPISVGLQSDPSSDPLTPVTRIFSSPPASTDWSPATSPLSGSGLPSKSITIVQDRGFVIKASLSSAYWSTMSYTGTSRVELVEIGFDIVSSVPSDSPLASRLPSKPSPASDFIRGLHLSDVVLRWLSENPREELKDDRIPLELLDRFEPTADLRLEKEVGSGSTAGGWLAKVVQVNRPLCSSAKAEAPLVDHPAPNTTYFLKLVTCRYVGSVIRETLFYQHVLPHLPEHLRKHIPQYHGTYRRTNGNGYAMVLENVGKTMNELDFYGSPGELWEIEAAFRELGIIHNDVRAGNVLVRPNNGLLCFVDWGRSYLKLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M7H3</accession>
    <name>A0A2X0M7H3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C001g00427 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C001g00427</name>
        <name evidence="5" type="ORF">BQ5605_C001G00427</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY46396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M7H3"/>
    <dbReference type="STRING" id="796604.A0A2X0M7H3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="47"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="685"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="685"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="734"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY46396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="953" mass="104272" checksum="3A11046623E0FE17" modified="2018-09-12" version="1">MTPTAPWAPTSTSSSTLATDSSPSSTGSSTAPAKAAAEPKRPIAVRACDACRRRKTRCSNQTDDGSAPCSYCSSNNVPCTYEPIKRGVPLADPAELLEARIKSVTSRIQELTSDSGVNLIKMLDELIENHDHDVLWTQQGIEIEHLARQIRAERIKSLSPAGTPSSSSTTSHAIRNRGGAWDSLEDDIALNRVHYVGRGSSPFFLQKLVRDMRAPAPIIDPDEPPSLVGELLELDYLNGSKPPNTLPPPDLLRKLIDAYFTEFNDRQLPILHRPSFERALNANMHLSNKSFRGLVFMICALGSRWVEDRRIDKIIANTSDSSGKNSEPCICKGLNWYRAAVGEDFSSVAAVIPATLFDIQASVLGIFYQMGSMTLVPVWSSIGNALQKAVDVGCHRETRTRWTSSPLEDQLRKRAFHTLYSLDRAISTNLGRPTSIIDGDIDLDYPLDISDVDLDDYNLRGPKSTPPATRDPSVVALIECMSRLSRIFGNMFNTLYGIHRPTTAEACTALVTDLDQQMNDWACAVPTHLRWNGEKLKPKFLTASAILYISYYELQIRIFRDFVAPSRSVLIPLRALDICAHATSSIAYINNWMLQAGRIDDLFWTVVQKMGVAFLTVLTFMFRQGASGASPVPSTLRDTRIFTHMFQKLSKHTLLAHIAMTYMRRLIETAVATYPNLIAYLETGTPGSTPPATVASTSGTTLPTRETQPAVSSAQPTEPDAERSGGPVHPTLGGFTSTLDNSQLKNAQDTVTATHPDAPSAAPNDAFAPLYPQPQATDASTSLPTFQIARPTLWLPSSSFGAPSSSITNPYDPMLMSDNLRATDLTPSAAQPTSLIPGATPTQADANLLNPFDAISWNTFPTFDPTLVGDSTLTNQYFDPLAMPHDWLLRSGALRRCEYKSFRPRSDASAKVIECEAPLGPTKRAEHLGRKVARSDLAVVDLDGISLELDVCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M9I9</accession>
    <name>A0A2X0M9I9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="5">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C006g03894</name>
        <name evidence="11" type="ORF">BQ5605_C006G03894</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="5"/>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY54624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003840">
        <property type="entry name" value="DNA_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02689">
        <property type="entry name" value="Herpes_Helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="9">
        <location>
            <begin position="446"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="8">
        <location>
            <begin position="1109"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="10">
        <location>
            <begin position="1408"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication helicase" evidence="7">
        <location>
            <begin position="1503"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="398"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY54624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1592" mass="178436" checksum="4639F19DF69D507C" modified="2018-09-12" version="1">MYQHTVVSAAPACGVHVPIRRHVQALWSPGRAIATSPSLGREDSAVPWASSSARCWAPRGSTLFFVPHRSTESAPRARVRRARIALKPLKPHVSIRDDLGPQTAVCTHCKARHWECERSKSTRHFSACCSQGKVRLPPPPQPNLEYRQLLQGSDSEAVAFRENARSYNNALSFTSLAALWDQTQVGTLGPPVFRVFGRLYHRLGALVPAVTQRPTFAQTWLIDPAEATDTRLQEPDSAETRIQRSTLTKLESMLRTGNRFVREFASAKARAGWDTAKEWVLRLCLPPGRDRRTHNLPTSSTEMAMLICDSDTNTGDRGPQDLILQVHGDRCPDGRPKYQIVSSLHPSAMPLRYPLLFPAGEDGFHPNIPLCGFNQAGPPIARNREQIDNGVQLRELLDGLGPDEEDEEEDDEDEGDEEDEENGDGERRRSNKRGRGGSTRVSRSQYFAYHLYERDDYFSIPHATQRLFLECVIGGYSQVETDRLNYIRLHQESLRLTTAQGITDAVANGLTPDQIGRSVILGSTFKNSPREITQRYQDAMACVVKYGKPSLFITVTCNPVWPEIKAALGPNDKACNRPDLIARVFEAKLNRLCDDVFGNKQRAGCFGVVLTHTHVIEYQKRGLPHAHILITLAPDDHPLSTEAIDKMISAEIPDPSRYPDLHETVTKHMLHGKCGGNSTQPCMEKDKYGNPRCKPHFPREQNPHTRMHPEGYPLYRRRFRHAVVKGGVIYNDGDCVPYSPYLCAKYNAHINVEAVTTIGAIKYLFKYRAANGEGAREDEPVRDEINEFVEGRYISAPEAVHRLFGFSVGRVWPPVNRLPVHLENQQSVQINPNEPLPLDTPPTRSKLTGFFDLCAAAPDGKLTTTLLYTNVPRYYSWNKEKLRWKCRVHDRNVIGRIYTVPLRSGERFYLRLLLEVVMGPTSFADLLMFEDVVYPSYRAACAARGLLADDGEHHICLREAAQIETGDQLRRLFVFMLIHATVANPPALLDRHFASLSDDARYHIERYEDVPVNDQTIRLWTLNKIRLLLAANDRTLAFFDLPELTEDEVRLFDRLEERLPRFDRQQCAQDAEAAHARLNHDQRIAFDECLCAVELDVVDQMRDNNLGPQHVFFLLAPGGTGKTFVENALLDTVRARGDQAIAVASSGVAALLLKGGHTAHSTFRIPLDTLPTSTCPVDRESDLALMLRTTKLIIWDEAPMAHRFAVEAVDRLLRDLRETEEHFGGVTMIFAGDFRQCLPVVPKGTPGQIVDASLIKADFWRDVRVLRLTENMRLSSNADAMDEAQLARTRDFAEWLLTVGDGTANMHPYDKIALPDYLLLPDGQRTAEGLINFVYPDLRTVNKESLEDLIQLFSRQAILAPHNATVYRINAKLLEEFNGDYIEYRSADEVVEAGETGGGMAPELISPEYLHSINPSNFPAHHLRLKEGIPVVLLRNLDPDAGLCNGTRLLVSHARSRVIQAIILTGDRAGTTVFIPRVRLETNATGSRQLGFTMRRLQFPLRVALAMTINKAQGQSLDRVGVDLSLHPVFTHGQLYVSLSRAMSVDRIKVLLPSRDPADDDDGLQAVDRAAAAATATPNPVFRSVLRAMNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MA48</accession>
    <name>A0A2X0MA48_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g04103 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g04103</name>
        <name evidence="2" type="ORF">BQ5605_C006G04103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY56034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MA48"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY56034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="276" mass="29156" checksum="5250815489435890" modified="2018-09-12" version="1">MNNSPSGLTDDLFSLALNSNTASSFGTATAGDAPFSVQQHIDRVSGLLEMMNMVVTLQKMNNNSLPWLPKSKLAEPIYAQVNNARWLSARRKLGSRLTNEETGQSRQFTFAFPCSSPLVHASGSSSTLSQSSSRASTTRHPAPAAPLPDPAFSRSTLSDARTSRSSPVHGDDSNGGRLFTPAARSARGRLSGAQLGLKKSASHAPSPFPAEAMQVMPISKEKSRKGKGVQRFARGKCESAMTAQAVVKAEGSVVLTCSSGGKALIDGPRRPDQEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MAR1</accession>
    <name>A0A2X0MAR1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g04166 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">BQ5605_C006g04184 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">BQ5605_C006g04304 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C006g04304</name>
        <name evidence="2" type="synonym">BQ5605_C006g04166</name>
        <name evidence="3" type="synonym">BQ5605_C006g04184</name>
        <name evidence="2" type="ORF">BQ5605_C006G04166</name>
        <name evidence="3" type="ORF">BQ5605_C006G04184</name>
        <name evidence="4" type="ORF">BQ5605_C006G04304</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY56749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY56870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY57759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MAR1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY56749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY56870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY57759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="55" mass="6080" checksum="8BEA2E2C0277DFB8" modified="2018-09-12" version="1">MAEALQAAGKDTASDRRDQCAVNRTRSRLRRTSHLGNADHLRRGSWNFAVATLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MAV8</accession>
    <name>A0A2X0MAV8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C005g03535 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C005g03535</name>
        <name evidence="3" type="ORF">BQ5605_C005G03535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY76962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MAV8"/>
    <dbReference type="STRING" id="796604.A0A2X0MAV8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF5">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016169359" evidence="1">
        <location>
            <begin position="37"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase" evidence="2">
        <location>
            <begin position="91"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY76962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="335" mass="36690" checksum="3CA5F7FD8A899830" modified="2018-09-12" version="1">MSQETFRSAIPLPGQSSKSLLLIVLLADTPLPPVKAAHGNYHDIFTSLFEHSVQLHASQINLGSKTTSGTQSEAVLTVESYDAVRGQYPTEDRVKEANGVLITGSASSAYEPIDWITKLVAYTTSLPKINPQIRLIGICFGHQIIARAFGSTVERNSKGWEVGVRVMDLTECGSSIFGGERLVSVAVICGDLCRKRLRRRPRKPTAVWDLLVEPRRRHHPHIDIPQAIHQMHRDHVPSLPSGFELLGSTPICSIHGMVKYSSSAPSPPSANLSDIEVLTLQGHPEFSPDIVLKVIQVRAERGVFDPEMAEKSRAHARGSDEGVRIGEVVLRIIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MBI9</accession>
    <name>A0A2X0MBI9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C005g03652 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C005g03652</name>
        <name evidence="1" type="ORF">BQ5605_C005G03652</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MBI9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY77495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="118" mass="12787" checksum="6C8C00430A37B784" modified="2018-09-12" version="1">MLVLPTHAGSRAVLATHVPFWAFTALSTFPPVDAIAVLPTRELTGGTRNARSLSGLHCVVDVSLPASMAAFTTCRDRCVPHSQDYLPADEVADREFHIAGRSQLLAARYETLDVARLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MBT7</accession>
    <name>A0A2X0MBT7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C010g06142 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C010g06142</name>
        <name evidence="4" type="ORF">BQ5605_C010G06142</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MBT7"/>
    <dbReference type="STRING" id="796604.A0A2X0MBT7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14810">
        <property type="entry name" value="bZIP_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="326"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="430"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="351"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY14326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="780" mass="82720" checksum="FD7B6CDAABADE30C" modified="2018-09-12" version="1">MDQFLDLDAINAAMGVGAISIVGSNGGSGAGGADGAGGATSTSHLVGAFDDQFNDMFQQYLAPELTKSAPMAATPIASTSELPFAAASADAMSFSNDTLDPRTYLPTLPGSPIGAFSPSSDNSGARINSLSPLSFPDLDGPGDSSAWTLDPAIFGGDPVPDMMTSQEAPASLFGDLPALPDLQVEASPESIKAESVTASSITITPHPSSTRASRASAQQAKRQLSEALRDEEEEEQEQEDDEEDEDDAEDDDEDMDSDHYSAPRSTRATKKARTISSNSKARSGSKAPRSVAVFATKELHHTNTRSNLPPVPEWTDKPDPDTYKKLSSKEKRQLRNKISARNFRHRRKEQLTTLEDEISSRDNIISQLQEEVGTMRTENSTLRSEVSMLKAKWDEMMEKMTAFQAPQSATAVSTATTGLGVRPRLVIASSTAASSPSDKTTDDDLWALDSPQSAPSPLPTVASGSRRGTRASNGITKPNLSKDVAPNMGGRRSTGSWATQGFGGGFTSVHTTLLPDPAALLNAKSSLANYPQQNFNPALNNISASSLAQCTQHLREGSLASGQQQAPAPRSTFEDFFASNPYWLRPDQVEEYRGQLYGKIANNTAGLIAAQKLGSSQLTSGSHLSMPNGFRPAFFTSSPSSARFAAPSMNGGKEPRDVGPSSDLLEFQSPRAALAQQQATALVATLATQTLFSKMTSAFVDAFTGSDGGKTMDANKVADVLAGRSKVQLVPQQSQQAAVSTPSIESLGLSLSSLDLSNDARSPSPRPHCSFNSMTKKWCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MC96</accession>
    <name>A0A2X0MC96_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C008g05186 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C008g05186</name>
        <name evidence="10" type="ORF">BQ5605_C008G05186</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MC96"/>
    <dbReference type="STRING" id="796604.A0A2X0MC96"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.430.10:FF:000001">
        <property type="entry name" value="Copper fist DNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.430.10">
        <property type="entry name" value="Copper fist DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051763">
        <property type="entry name" value="Copper_Homeo_Regul"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001083">
        <property type="entry name" value="Cu_fist_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036395">
        <property type="entry name" value="Cu_fist_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00649">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00617">
        <property type="entry name" value="COPPERFIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM01090">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00412">
        <property type="entry name" value="Cu_FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57879">
        <property type="entry name" value="Zinc domain conserved in yeast copper-regulated transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50073">
        <property type="entry name" value="COPPER_FIST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Copper-fist" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="176"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="540"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="177"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="551"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY79648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="702" mass="74193" checksum="D731587C81F8AF9A" modified="2018-09-12" version="1">MVLVDGVKFACQSCIKGHRSSKCTHTSRPLVEIKSRSLVAGLAPGPLGRSDLSVPDRDHRGLAQLCTDKKGRPTSQCSHCRDLRKTRSVHGKCDCVGKEYEEKPLQQVLPNGLSDLMRAREDEAGASAEPVKGGAQIEPNGHNACTVSRLLNPCNCRRGGKCNCCSVVDRSKKSRLSIDSTNSSSAPSPIASTPRSRSASRTRNAGVGGCCSSKKASSDAASPITASPAISAEAFSPASTAFNFSSPDVPVYTPFASTSYLPAAPTPLSQTFSSPFQFHSASSTATPSVFAPTTDLGGCIGDDPTCTLLLAHLQANAPPPTDQSSTSSASDPAFALLLDPWSSTPFAHSFVPHQTPLFLPHTQGTSACFCGDSCTCVGCPQHDPLGQKRAPTHNPGPGCGCRNRAAESAPPPLTLQTTQLQPSGKRVCCRINTDVEVPSEVSSIDQLLQSVIDLDSPCEITSSNQCAMTLPGLWNDGGNEAIAANLPGVNDVWRGLNISNDPWFTTLANPEAPQALPLFIAPEQRQKRKAKAQSVWALQPLPESGDPWSATHPQASSSTTDSNETFSNPFQRNEANGCPSMYAPAADDPLGLQTLNEGGEDEDPEPGCGDECQCSSTCACRNMDVVDEDNPEGHWHDDFEALSTPASGLSTPLQIYGPQSLNTTEESEVPTQQMAATSLGNAVDLSFSFENFDNFKAEDVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MCF4</accession>
    <name>A0A2X0MCF4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C004g02607 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C004g02607</name>
        <name evidence="4" type="ORF">BQ5605_C004G02607</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. FUS2 hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY65933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MCF4"/>
    <dbReference type="STRING" id="796604.A0A2X0MCF4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050261">
        <property type="entry name" value="FrsA_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946:SF9">
        <property type="entry name" value="POLYKETIDE TRANSFERASE AF380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="43"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY65933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="356" mass="39814" checksum="EC2D2E12EDCAFBEB" modified="2018-09-12" version="1">MASRRPSKTPPRQDIEIPFGAARMSAWFYPSPIATTDKPGPCVVIGHGLGAFKLMRLDAYAETFQKAGYSALAFDYRGFGESTGSPRQILDWNAQQEDWKVVLEYTRTEFDQVGKFSIEVIRAVDFGTSVGYDPDSKDPERIAIFGTSFGGGESKLHKYIENFRLTSSASSTAHAITAASKDKRIKAAISQCPFTSGFHSSLTVDWKTLPWVLFAATKDVLFGTKESYTPIKVAGYPGEPALMNAPDAMTGFNRFVSKDYRAQHPDREYVAARIVFQMPFLYPGRDAKRVQCPIYFAICKNDSVAPPGATMRYAKQAPRGEIKEYGAGHFEIYFDEHFEEATKDYVDFLHRHLPPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MDL6</accession>
    <name>A0A2X0MDL6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C004g03017 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C004g03017</name>
        <name evidence="8" type="ORF">BQ5605_C004G03017</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY69451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MDL6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000008">
        <property type="entry name" value="Cathepsin D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="7">
        <location>
            <begin position="237"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="110"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="171"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="441"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="268"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY69451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="556" mass="57162" checksum="DD8D603D462F0644" modified="2018-09-12" version="1">MHAKFKRGTSAYLENQGEALLPASDRALYGGYGVVSGAMMGQKRAWMEEGNPMEWDESPGQIEEPHAEHLQIKSRGVRSVSGGRDPTKQRRGGDTLFSVERFKGIRGAGRLFGRGLKPPREGPVESVNEASSDLRVNAAKPTQQSRKDAVASRAAARAAAESARVDGGGNKATTAGGQKATTAKTTAATTPRAGARATTTSTGAKAAATKGGGSSSSAGGVSLTNYNDGSGLRHAVWTGTISIGTPAKTFNIDFDTGSADLWVPSSGCSSAACAPHTKYDPSKSSTSKADPSKKLSITYGDGSSTTGLVYQDTVTLAGLTTTGQGFGVATGMSSDWASDPMDGLMGMAYASISQTKTTPFFQTLVAEEQVAAPQFSFRLGASGDSELFLGGMNSNDYVAGSTQWTRVVSQGCELHRTVIFLHANANVNGKAALKGINAIIDTGTSVIVAPTADAATYWAAVADSAPYGGGGGYYTYPCKASLTASFTFAGGSQKWAVLSNALNLGKVAAGSDRCVGAIVGADVGISGWVLGGSFLQGVYVTFDLGSNRVGFSTLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MEX7</accession>
    <name>A0A2X0MEX7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BQ5605_C005g03469 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C005g03469</name>
        <name evidence="12" type="ORF">BQ5605_C005G03469</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY76142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MEX7"/>
    <dbReference type="STRING" id="796604.A0A2X0MEX7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016428">
        <property type="term" value="F:tRNA (cytidine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057285">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057286">
        <property type="entry name" value="PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023270">
        <property type="entry name" value="RCMT_NCL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF1">
        <property type="entry name" value="RNA CYTOSINE-C(5)-METHYLTRANSFERASE NSUN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25376">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25378">
        <property type="entry name" value="PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02011">
        <property type="entry name" value="RCMTNCL1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="11">
        <location>
            <begin position="67"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="428"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="445"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="211"/>
            <end position="217"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY76142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="843" mass="92217" checksum="B484EAB9707B1CE1" modified="2018-09-12" version="1">MGKRRGGRSGGGGNGGNRTGSNAPSSTNRGSNQRTTAWTSTEPIASEIFLKYYKAQNLVPEEEWDEFLHALQQPLPTTFRLTSCRAVAPRLNQQIEETFVPFLTGIEHEGVPLEAPKKLSWLVASQTLTSKPLLKHLGFFSFPRAFRYPGGFAWQLNIPRQAIRKQDAFKKFQHFLVHEADCGNLSRQEAVSMIPPLLLDVQPHHHVLDMCAAPGSKTVQLLEALIGSEKLGGQASGGLLIANDSDAKRCHLLVHQSLHRVPGTGMMVTNHDATQLPGLRLPTLATNANAGKFIGDDKEEEEEVVTEGTKRQKKYEPLLYDRILADVPCSGDGTLRKNLAIWKEFTPGNGTGLHSLQLRILLRGIALLKPGGRLVYSTCSMNPIENEAVLSAALSLCPEMSILDVSSSLPELKRRPGMTEWVVLDNAGNPPLHPDHPVPSPTPVPEVTSATEGETAATARQGNKKKEKVWSKTLWPSGKEKELGLEKALRIYGHLQDTGAFFVCVLVKKGANEVAARGGEETTAKRTSDDVEATVPEAKKAKSEPEVEKETETEAVVEDTAVEEQVDVSSLPAEIVGANVFSTKTRDFKEEPFIYLNPDDEQVRIFSDFFDLSPLFPRENLLVRNAAGAPLRSIYFTSSSTRALLLSNSFTRMRLISCGVKIFTRQDSTRDGTYACKWRVNSEGLEVLRPHMGTKRIVTASVETLRRLMSSLTVGFEELDEVAFKERIVEMEPGSCVLEVDAKGEGLLFEQKLSLPFWRSKNTVNLMVEKVEKSALSLRLFGEDLTPHKIGPKARDLAKAQGKAKVQGEAATAPVAGAADAAALASEKADDVPLVEAAATENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MF70</accession>
    <name>A0A2X0MF70_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C014g07447 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C014g07447</name>
        <name evidence="2" type="ORF">BQ5605_C014G07447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY18702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MF70"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY18702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="114" mass="12176" checksum="210930E91C3D12CD" modified="2018-09-12" version="1">MTTVVRNLDVVAPDCPAHQHSTVVDKFPLVSVVQHNPSRSLMMAHLESKNRSLGYAAAARQSASARLATSPPGSPLQRRPALQPRNDPARAASRIASDPWSQLNKRAGSAGFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MF88</accession>
    <name>A0A2X0MF88_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C005g03410 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C005g03410</name>
        <name evidence="2" type="ORF">BQ5605_C005G03410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY75257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MF88"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY75257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="147" mass="16899" checksum="2597D945DF551BC9" modified="2018-09-12" version="1">MSLKRGNLIFSGLGLFCLPLDILFLSRASQNVLIALRSTRMGVRFAGISVTIMFLLRFRAQFEFEIVELLRTAHLLFVYDHLFSLFICGFIEVSLEIVFVAVFVRLSAEFSIHIIGVIVIDRHWDRVTDCCRQKTSPKVRMEIGQDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MFD5</accession>
    <name>A0A2X0MFD5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C005g03619 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C005g03619</name>
        <name evidence="8" type="ORF">BQ5605_C005G03619</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MFD5"/>
    <dbReference type="STRING" id="796604.A0A2X0MFD5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050911">
        <property type="entry name" value="DRAM/TMEM150_Autophagy_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324:SF2">
        <property type="entry name" value="EG:22E5.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324">
        <property type="entry name" value="FASTING-INDUCIBLE INTEGRAL MEMBRANE PROTEIN TM6P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="7">
        <location>
            <begin position="20"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="267"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY77377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="313" mass="34745" checksum="BF78893454DAFC83" modified="2018-09-12" version="1">MSPDHKPPLNFQIVLVRGQYWIIPTLAAVFWLATLLGLLLWWIVDDNSKQYMIDEATVVFISDVGAAHKGLFISGTALTFVFFSATLLTERWLRHIRRIPGALKKKETVYDILCCVFGILGGLALMLLSIFDAFNHSKAHWTLTLVFVVCIALSAIFQTLEVMSLERDHVDRNHLRRTAIIKLIIVSVAVAGAIGFGVTYGICAGANNDVAPTARCNIVQSAAASLEWFIAFLFFLYICTFILDLLPARKTEGHKFHPGLIEADKSNMLHEHKNGRPGAPRGLDSPVRRASEDDHSLGPRVGRTPEDQGLQQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MFL3</accession>
    <name>A0A2X0MFL3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Methionine aminopeptidase</fullName>
            <ecNumber evidence="10">3.4.11.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C005g03679</name>
        <name evidence="12" type="ORF">BQ5605_C005G03679</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8 10">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="10">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with zinc, cobalt, manganese or divalent iron ions. Has high activity with zinc; zinc cofactor is transferred into the active site region by the ZNG1 zinc chaperone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Associates with the 60S ribosomal subunit of the 80S translational complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="10"/>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MFL3"/>
    <dbReference type="STRING" id="796604.A0A2X0MFL3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031615">
        <property type="entry name" value="Zfn-C6H2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF7">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15801">
        <property type="entry name" value="zf-C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52013">
        <property type="entry name" value="ZF_C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 8 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8 10" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C6H2-type" evidence="11">
        <location>
            <begin position="21"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY77597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="424" mass="46685" checksum="6B9FEDE915764A48" modified="2018-09-12" version="1">MVTATTNGSSASSTPRVIDSGIPCVNCGKPASRSNTCKLCQDQNIVSLFCTPDCYRSNYKTHKKLHTPAAQGNYTFPPDTADPFAGRYRYTGPLRAVYPKEPVPTRAVPESIPRPEYVNNAKGRSFAEEIANRTERYGRILSKKEIVGMREVCRVSRWVGTTVTWARLCSSRCFSLSKLGREVLDIAASKIAPGVTTLDIDAVVHEECVKRNAYPSPLGYHRFPRSVCTSVNEVICHGIPDARPLEDGDIVNLDVTLYYNGFHGDLNATYPVGTKASDENLRLMKTARQCLDEAIRLVKPGTQYKDLGSTIEAIAKKDGFSVNHTYGGHGINNLFHCTPNISHYAGNKNIGVMKVGQCFTIEPMICVGQYKEDHWPDVWTAVTVDGKASAQFEETMIVTETGVEVLTAAPGWTLPERDTEIVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MFS3</accession>
    <name>A0A2X0MFS3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C008g04900 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C008g04900</name>
        <name evidence="1" type="ORF">BQ5605_C008G04900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY78613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MFS3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY78613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="214" mass="24304" checksum="B0B3EA6ED5E86573" modified="2018-09-12" version="1">MPEFDAEDFNARDFNTPSRKPCPHACLPPNFPKHAPRYLALQTTLATQRASVQGRFPSFKCVTLSKQSRGGARFFDARGDNPSTVRFPKSEHHRDFIQATIDEEVTKRWVSSGSAFPLPGVTYNSIFVVESANHRMRVVADHTSSGLNDGIQRSDCPTVYDTIIDFIRLLRWHRFSSKLLTGNSVLWKLDVSSAFKILIMSKRWQARLDLYPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MH19</accession>
    <name>A0A2X0MH19_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C033g11220 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C033g11220</name>
        <name evidence="9" type="ORF">BQ5605_C033G11220</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000066">
        <property type="protein sequence ID" value="SGZ02634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MH19"/>
    <dbReference type="STRING" id="796604.A0A2X0MH19"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000286">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF3">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="398"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="263"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="275"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGZ02634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="513" mass="55255" checksum="90626BDF3F0CB28E" modified="2018-09-12" version="1">MEPDYANTSPASRGATSLQVAQEDRRDLFIKEASCHATMVCAGWSDSSSGPLIPYIQVCLSRSCVEGSAGLNSEPLIVRSSAVPRHRSWHVRPTLASATPLIGQMVGFLTAGFSNSYWTEKYGLGKVIAVGSIIQLFGFIFLIPAFAFPVMPVCYILLGFGMALQDAQANTYIATLPNVEFKMGLLHASYGFGALICPLAATAFASSGIRFSYFYSVSIGVASLNAAILLYAFKFSYRIPKVLPAPMTTPPNEREAENGAIELESISRNGPPAADRNDLTDSKERGEDGMRTPSSTNGQQSFQYPPGPSLEGGVLPPGKDKGILRQTLENRTVWICCLFILVYVGAEVSMGGWIVTFLIDNRNGGPSAGYVATGFWGGLTLGRAVTSPFNIWFGEKRVIWLYLFIATGLEFAIWFSRDFIGNAVTVALVGFLLGPIYPITMSICTKVLPRSLHASGIGFIAAAGQAGSAIFPFLTGALAQKFSPSVLQPVLIILFVVQAVIWVFCPSPDRKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIG7</accession>
    <name>A0A2X0MIG7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C009g05692 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C009g05692</name>
        <name evidence="2" type="ORF">BQ5605_C009G05692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY84362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIG7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY84362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="45" mass="4713" checksum="C67F21AD000710D0" modified="2018-09-12" version="1">MCNDVARNQGCTAGWVVGELPPSSGLITPFLVWAVVVVPCLLIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIS0</accession>
    <name>A0A2X0MIS0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C011g06607 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C011g06607</name>
        <name evidence="2" type="ORF">BQ5605_C011G06607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIS0"/>
    <dbReference type="STRING" id="796604.A0A2X0MIS0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY12796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="226" mass="25707" checksum="DF22FD1971C6C04D" modified="2018-09-12" version="1">MGTRLAMSTSFHPETDGRSERTNKTAIQALRAVVNHQQTDWVRHLVNIEFTINASVNASTKKLPFKVVLGRLPSLLPTSLNRPNLPEVPAAKDLIAERKAVLVEVRDALAAAKVRQVEQVNRHCRPEPEIVTGQCKSAKLFDRFEGPYKVLATNVATSNYTLQLNEGDQSHPTFHILEETTRGKKRFCVWWEGYPQHEATLEPREHLEGTEALRRWELKKRTEGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIZ3</accession>
    <name>A0A2X0MIZ3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C039g11756 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C039g11756</name>
        <name evidence="3" type="ORF">BQ5605_C039G11756</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000060">
        <property type="protein sequence ID" value="SGY89554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIZ3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052925">
        <property type="entry name" value="Phage_Integrase-like_Recomb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34605:SF3">
        <property type="entry name" value="P CELL-TYPE AGGLUTINATION PROTEIN MAP4-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34605">
        <property type="entry name" value="PHAGE_INTEGRASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY89554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="582" mass="65609" checksum="9C91F300118ADD7F" modified="2018-09-12" version="1">MSFEDSRAAWRLRQRAVPYPTMPTIAVRERAFKSGRALTGRADASSSALRDGAPAAAPPPTVKLDRNPGACLGFTSKSNPRLPMLRSSHSGDIVVYLPEADGNEMALMASSTNCTPEERLCAAFAKTYRGINRILVLTPTTPVQRPLHACALAATEHAVMVAAGRTAESNEMYAMDRFPAHPDVVRRFLTRIALSGNGVGAYSVSHFRRFRTALEFWHTTHGLRMNYNPKMWTMQLAAAAATAPAPKPERLAATLDKDEEFIAERHLAVASARRIDATSEAPLRFELDLPFDKVRRRVGRTLVVSARDGEPFCPVGGIDNHFRLNDFPPGRLFSYRAREGGHRQLTFSAFSRRIKHILEASGRAVLNNHSFRSGGATFYLREGVHTDHIRNLGRWSSNTFDGYWRVSSRKINHLPHPNTTKHTERYTRKVAIPFPRSRTPLASDRDIGGEKRWAREMPVRFCTLSVSLEQQCLLPLHSRNFSTHPPSRIRCYLIPREYWRFCNPRSLGCTHHPRVSSRKINHLPHPNTTKHTERYTRKVAIPFPRSRTPLASDRDIGGEKRRPVLACCDHVNARVSFSEVKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJA5</accession>
    <name>A0A2X0MJA5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="12">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="12">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C034g11290</name>
        <name evidence="12" type="synonym">ALA1</name>
        <name evidence="14" type="ORF">BQ5605_C034G11290</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>tRNA(Ala) + L-alanine + ATP = L-alanyl-tRNA(Ala) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="12"/>
    <dbReference type="EMBL" id="FQNC01000065">
        <property type="protein sequence ID" value="SGY99551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJA5"/>
    <dbReference type="STRING" id="796604.A0A2X0MJA5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070143">
        <property type="term" value="P:mitochondrial alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00673">
        <property type="entry name" value="AlaRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.130:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.310.40:FF:000001">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000011">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050058">
        <property type="entry name" value="Ala-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059090">
        <property type="entry name" value="ALA1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777:SF9">
        <property type="entry name" value="ALANINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777">
        <property type="entry name" value="ALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26023">
        <property type="entry name" value="ALA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 12" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="13">
        <location>
            <begin position="12"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="604"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="608"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="723"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="727"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGY99551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="954" mass="105246" checksum="259C94A2C1FFD810" modified="2018-09-12" version="1">MSSTTSSQWGDWPAVKVRQTYLDFFQRAQHTFVPSSSTIPYEDPTLLFANAGMNQYKSIFLGTVDPSSSFAKLKRAVNSQKCIRAGGKHNDLDDVGKDTYHHTFFEMLGNWSFGDYFKNEATEFAWKLLTEVYGLPKDRLYVTYFEGGFGLPPDLETKNFWLALGVEEDHIVPGNAKDNFWEMGATGPCGPCTEIHYDRIGGRNASSLVNQDDPDVLEVWNLVFIQYNREADASLRTLPAQHVDTGMGFERLVSVLQDKRSNYDTDVFTPLFKRIQELTGARDYTGKLGAEDMDGIDTAYRVVADHVRTLTFAICDGGVPSNVGRGYVLRRVLRRGARYVRKKFGVSIGHFFSDLVPTLTEQMGDFFPEIQGKYDDLKEILDEEEESFSRTLDRGEKLFDTYVAAAQASGAKELAGRDVWRLYDTYGFPVDLTLLMAEELGLTINQDDFEKAQEASKEASKGAGKKGDGQSVRLDVHDIAALEANAAVPKSDDSFKFGLGNVDATVKAIYHESKFYDSSAEVPAGVTFGIVLDKTNLYAESGGQEHDTGRIVIDGSADFAVGDVQVFNGYVLHIGSIKEGTLKVGDGVVASYDELRRWPLRNNHTGTHILNFALREVLGDHIDQKGSLVAPTKLRFDFSHKAPIPTNDLAKIEELSNAWIKKNVKVFSKEMDLKTAQQIPGLRAVFGEAYPDPVRVVTLEFSIDEIQKDLTNPKWRGTSVEFCGGTHVAKTGDIKEFVLMEEAGIAKGIRRVIAVTGEEAHQASRLANETEAKYASIEKLSGKARDSALKSFETELATAEIGVVRRDQLKEKVKGARMALINEGKAFEKEESKKVAETVAEYFKANPEAEVFIASFEQAQANPKILQAGSLQAKALDKAAYLFSAEDGKVLHLNFVPKAMQSKAFNAKTWLTGVAAIVGGKGGGKDDSAQGVGSEPTKVQEAIEQAKKLFAGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJB9</accession>
    <name>A0A2X0MJB9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 12">13 kDa ribonucleoprotein-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C029g10646</name>
        <name evidence="14" type="ORF">BQ5605_C029G10646</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9 12">Common component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA. In association with box C/D snoRNPs, required for processing of pre-ribosomal RNA (rRNA) and site-specific 2'-O-methylation of substrate RNAs. Essential for the accumulation and stability of U4 snRNA, U6 snRNA, and box C/D snoRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 12">Component of the U3 snoRNP particle. Binds to the C'/D and B/C motifs in U3 snoRNA. Component of the 25S U4/U6.U5 tri-snRNP particle, a subcomplex of the spliceosome. Binds to the 5' stem-loop of U4 snRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
            <location evidence="1 12">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ15153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJB9"/>
    <dbReference type="STRING" id="796604.A0A2X0MJB9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21104">
        <property type="entry name" value="SNU13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000002">
        <property type="entry name" value="NHP2-like protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002415">
        <property type="entry name" value="H/ACA_rnp_Nhp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00883">
        <property type="entry name" value="NUCLEARHMG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="13">
        <location>
            <begin position="55"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00066222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGZ15153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="162" mass="17582" checksum="DEAF8E83246CCBB1" modified="2018-09-12" version="1">MASTASLLPTDYATLGSFSFPPFSSAHILFTFVSTVQAEVNPKAFPLADAALTSQILDLIQQASHYKQLKKGANEATKTLNRGIAQIIVMTADTEPIEILLHLPLLCEDKNVPYVFVPSKTALGRACGVSRPVIACSVTTNEARELQGQIDTIRNQIERLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJJ2</accession>
    <name>A0A2X0MJJ2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C033g11146 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C033g11146</name>
        <name evidence="3" type="ORF">BQ5605_C033G11146</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000066">
        <property type="protein sequence ID" value="SGZ01437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJJ2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ01437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="127" mass="13105" checksum="FF23FE96B3EACDB2" modified="2018-09-12" version="1">MLGLGSTRAANSLRHAMTSGSVRATPALAHRPVMQAQQVQQPQRRTYVESVGGPASTAPRKMIDDNHAIMLGFAVGGLGLIWFLLYRASPTSATPPPTSPSGTTIPHPPIEAGSSAPAPGPLSTSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKA4</accession>
    <name>A0A2X0MKA4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01305 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01305</name>
        <name evidence="2" type="ORF">BQ5605_C002G01305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY32021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MKA4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY32021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="144" mass="16446" checksum="00DBCECEA3641B27" modified="2018-09-12" version="1">MSLKRGNLIFSGLGLFSLPLDILFLSRASQNVLTALRSTRMGFRIAGISVTIMFLLRFRAQFEFQIVELLRTAHLLFVYDHLFSLFICGFIEVSLEIVFVAVFVRVSAEFSIHIIGVIVIDRHWDCVTDCCRKKTSPKVRMEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKV3</accession>
    <name>A0A2X0MKV3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C030g10858 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C030g10858</name>
        <name evidence="1" type="ORF">BQ5605_C030G10858</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000069">
        <property type="protein sequence ID" value="SGZ09256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MKV3"/>
    <dbReference type="STRING" id="796604.A0A2X0MKV3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ09256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="286" mass="32141" checksum="3645470A59BB39D3" modified="2018-09-12" version="1">MTRRTSPVSGSLLSSKSITIVQDRESVIKASLSNAHWSMMSYTGTSRVNLVEIDFDIVSSDRSDSPLSSLLSSNPSPATDFIRSLHLSDAVLQWLTEDPKDELEDDRIPLELLGYFEAAADLRLEKQVGTGSTADGYLANVVRVNPRWSSPANREVPLVGHPAPNTRYFLKLVTCNHVGSVVRETLFYQHVFPHLPDGLQKHLPQYHGTYRGINGNGYAMVLENVGTHMNYSEFYERSGQWQEIEKAFVELGIVHNDIRQGNVLVRPDDEGFCFVDWGRSYLKLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0ML25</accession>
    <name>A0A2X0ML25_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">BQ5605_C107g13190 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">BQ5605_C107g13190</name>
        <name evidence="17" type="ORF">BQ5605_C107G13190</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000076">
        <property type="protein sequence ID" value="SGZ11138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="16">
        <location>
            <begin position="438"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="SGZ11138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1290" mass="142876" checksum="7B74B18803EBC883" modified="2018-09-12" version="1">MDDTSPPLATGVHPTFPADQLAALTSLLTTRPAFPKHARLDGPKTFANWTRQLRLCLADDIRSYVLDGIVPVDWTPSQRSARDVVARELLANSIDSAEVSAVLDAIPTADLTAPKIYLTLKSWYAPDDATRTLELFSRLWSFRPMPGTVGEFDGWIMEFKAIAQEIIDTKTTINDASFTDEQRTQRSLPAIDSLADRMRVQLRSTPSHRVAECPVRAKHPPPGPCRSCKQNHWSFDCKKALENGKKADTANSTANSQHHVGIATGFLLSLFTTYRHIAPTKIGGIAGGINAIGTGNIAFVAASGHPITLTGVLHTPGLFVNLLSVSRLCDTDDVRVAFTKHGIDIDKNGHNIAEGTRLDEGLYLLDADHSKCQHIALLSRSQSSVPLLTLHRCLGHLAPSSIQKMVAAGLLEGLRAGYSDEEVEKFVCNACLSAKGHRLPFPDSDSHSSERLGLVHSDVLSLPERSLTGKRYLVTFLDDYSRKLWAYAIGHKSEVFSVFKTWLAEVELETGATLKVLRTDNGGEYCSRAFTDFCKVRGTRRQYSIPRTPQQNGRAERVNRSIVEGILALLADAHLPKTFWEEAAAYFVYCKNLVQHSALDKATPNSVWQGGRTTASALHPFGCAAWLTVAPELRSKLDPKAVRVLFTGYDLASKAFRFYDTTTKKVTLGRNATFVDTEFPGLCGDSAEPDDDTHFASAPFADPQTTVKSWTPLVSTYREPASAEESPDELDLIGRHSRDESPDEIDFLTRHHRAFIATDDDTSDTEAIEPVKSITSDPQTWREAMSGDKREVWAKAAADEFNSMRDNFKVFTIDDRSTVPAGATIVSSKFVWKTKRNALGEITGHKARLVAQGNRQRDGIDFTETFAPVARFSSIRSLLALAATNGLHVHQADIDKAYLHGDLDHDIWMTAPRGFDLPGDKVLRLRRSIYGLKQAGRIWNRHIDASLRDLGYTATGTDHCVYSRLDDRQRPHYIALYVDDLLMISPDLAEIERVISGLEQRYGVKRLGPAEYILGIQIRRLDDGSIALSQERYIMDVLARFHFDTTTRGTTVPMTPGLSLTAIPGQATERIRSWYLQAIGSLLYISLGTRPDIAFAVSYLARFANNPGHRHWIAVKHIFRYLRATYRDELVYARGEARITGVVGYSDANWGACVDTSISTMGYVFYIAGSAVSWSSKRQSRVADSTTDAEYLALSHAGKEGIYLSQLLEELHVQPVAPAHIFTDNEAAAGKQRPLQKTLTTREEGISRRKVDWAAAGDRGTTRRGRGCEARSKSSISDFIANEIENEGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MMR9</accession>
    <name>A0A2X0MMR9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C029g10740 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C029g10740</name>
        <name evidence="1" type="ORF">BQ5605_C029G10740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ16207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MMR9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ16207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="284" mass="31336" checksum="C7E9983FA0525601" modified="2018-09-12" version="1">MRPARSARLSPEPRRQARSARIVLDRAESGFLTTAIPGQATERIRSWYLQAIGSLLYISLGTRPDIAFAVSYLARFANNPGHRHWIAVKHIFRYLRATYRDELVYARGEARITGVVGYSDANWGACVDTSISTMGYVFYIAGSAVSWSSKRQSRVADSTTDAEYLALSHAGKEGIYLSQLLEELHVQPVAPAHIFTDNKAAAAVARDPVRVTGTRHIRLREHFVRDMVNRGDISLSHVGTSDMVADIFTKALGPKVFSTHCYALGLRTRHPRLGSASHSRGGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNR5</accession>
    <name>A0A2X0MNR5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C023g09622 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C023g09622</name>
        <name evidence="2" type="ORF">BQ5605_C023G09622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ23691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MNR5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="729"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="907"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="963"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="760"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="963"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="991"/>
            <end position="1000"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ23691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1022" mass="108511" checksum="09E81083AD578A31" modified="2018-09-12" version="1">MTPQTQKGSTRRMTRNSNPDDVPRRVLVDDSAPKAATAAAVDRQASAPAVESTPSGGRDEGGGDGDDGAASTMKASLKKSSNKRKTALNTVTSKKAAAPKKSAKIQGTAEQAQAQAPAQAGPSSTTMQYTDQSLPLATSTTSANTHRATSLQAIDEVDANARARACEQNEMPSSDSELTSSDDSNDEPYLPSRKRGPSGATWAFKRRRKPAGPINTNQKSHVERTESKSVISRFDHSSTRALGNFPALQSLTDNVEAVLHNARTRTHSGRKLQSESHQRLKASIEVLPDPPQRAVLALLLNRYTSFCETQEVNLPAFPLSQPAKVAIFLARATDTSFGESLRRRLPQPFTYPLPIAGGDDQGSFLGPSEGSRVDVALMRCWLQAFSYAQGAIAPVWAPVLSPLDPSLASIERDPAITDIVATFHEPEARESSSYRAKPTAVGSRRSGGTRKTSQVATVPVDLAKRRQDLQAAGAKTAQRTSAMKSLSKAISEHNARAARRGSMSIQRPCDATSLMPCIVPHPATGHDASTVEMSHRTQNIPIGIGPPLSWPHGTRTPSSSNAPPPWPLSTYGSIPPPPLPIGPETFIRHYAYNTTPTQPGSTYPIPLTRSNSYEPHLRSASTAFSLSDFQSMAGEAVQPASTPHLSERLRSEQNGMHSTSAGSQFDFQHEAADTVRALIHQGDPSQARGQRWSRPPRIGMLQSGPKGYEVGAQDSGPGILQHFNGKDEMSLGAVSSSPSMMPPPASTSLSASARRDSLVQSTPQRSSSSTATVLQEGLFVSPTIPVSHGNGSQFEMGSSMRWDALPSAPTLIALAADVRPVGWFIEADTMRTIQIGAPPTTTSSHSSAIIPRGVINVQGPSTLGNPYFSMPVARSPRVRPNEAPESAVVEPQPIAGLSGEIAMGAHANDSQNMDGTLDRISRPSSTAGSAPPEQHRSSSHAGLGVAAGLEGTFLLGTSATPSTSFAQNGQNSSKLISATPLNKYEPHTHLNPVSPSNARPTDSPIYRESPLSLKEVSRAHST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPE9</accession>
    <name>A0A2X0MPE9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C022g09439 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C022g09439</name>
        <name evidence="3" type="ORF">BQ5605_C022G09439</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MPE9"/>
    <dbReference type="STRING" id="796604.A0A2X0MPE9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09212">
        <property type="entry name" value="PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036339">
        <property type="entry name" value="PUB-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018997">
        <property type="entry name" value="PUB_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09409">
        <property type="entry name" value="PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143503">
        <property type="entry name" value="PUG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUB" evidence="2">
        <location>
            <begin position="103"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ22164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="344" mass="38216" checksum="66235201692A5187" modified="2018-09-12" version="1">MQPYNPWTDPAPTSLSNSTPTSATSPGSSSDPALAPHQAALLAAEARAQAQALAATPPAQPTDAHRQQHVPFDPLTFQAGAKDKLPFHRILDTQLLPKCSKSQAVQTLQLMQTILGNLLEPPNPAQAMKYRQLRKSNAQIQRHLVDVSSAAAIDFLLLCSFRIQVIDFTEYLVYPPCPSAKQLHQLKLGAHVVAVVLGRAKEAEEREGRYRQSEKDVQEERKKKALLQFEEDRRIKMEKDQRERIFRTEKARQASEAEAKAELERLRLQADDASDHPVFTGSTSAARSMTIQQNDDDDEDTERPPSYGSVTGRVLGTGEAVVDHDGFVQNPDLEDSDEEEYEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPI2</accession>
    <name>A0A2X0MPI2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C022g09479 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C022g09479</name>
        <name evidence="2" type="ORF">BQ5605_C022G09479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MPI2"/>
    <dbReference type="STRING" id="796604.A0A2X0MPI2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045053">
        <property type="entry name" value="MAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451:SF39">
        <property type="entry name" value="MANNAN ENDO-1,4-BETA-MANNOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ22361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="584" mass="65604" checksum="73B7717BD8C2D7DF" modified="2018-09-12" version="1">MLVTAHVTAPFSLSQRLGFSVIFLALTMGLLSNLKLKSASVTDKTQIFLNSGGSTSSTARDEQGGSRDGSEWTSVDPRDQFVRVHKGQLVLAGHPFRFAGLNAPELLDGNVNGPFEIEHTFRTLSMRGSFARAVTRTYTLQINSKNIGRGHIKSWHREWKDWEWDEGRLKEIDRVLAEARKYGVKLIIPIINQDTGEDSNWVGSYADLIRMRKGLSTYEESTKVNWWTDHEMIESQLIIDKLLNRVNHINGIRIGDDATILAFETGNEMNCNGMRPAPASWTLRIAKHLKSRAPQILVMDGSFARTESITGSYPIEVLQSKSVLSRYYTYDSEGAIRLTRPRCRFRHSDVDILSYHYYGSGDSYRVKKDCEYVFGKHGKAFVAGEMGFFAEPSMYDSFLKDLHKYGGSGALVWSLRPASAGGGYKTHGEGNGNFAMHIPGWATCSHPEFDPRERQIISILRHHSYKMNHQKTPTQHPVPPAPSKVWLDPSSLDQTHLLWTSAPWAHSYELILRDLSTGHEYGRRQVWDCTKEGESRLELSRELGAAPRTRLGVCLRGISLDGTPGPESEMLSLDSSISNDLAIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPR0</accession>
    <name>A0A2X0MPR0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C001g00112 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C001g00112</name>
        <name evidence="1" type="ORF">BQ5605_C001G00112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY44078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MPR0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY44078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="125" mass="13755" checksum="204B8EE4A486F8C2" modified="2018-09-12" version="1">MATPTAAEDLVATVFSTEAEAKVFYTELRSAGPEDRLQARCADVARAFLFSRTSGKWDHFDVVVFRSNGKLKIRATCKTRPASHCETVDFETAHQHGVSNWNRGIKQCLASRGEHKGICWGGVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPT2</accession>
    <name>A0A2X0MPT2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C022g09579 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C022g09579</name>
        <name evidence="3" type="ORF">BQ5605_C022G09579</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ23042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MPT2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015882130" evidence="2">
        <location>
            <begin position="17"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="603"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ23042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="803" mass="89221" checksum="104E26D6AC592615" modified="2018-09-12" version="1">MVLSVLLGLDVYSAGASPLFRYTLHPKTGITPVAFRTLYLRPSELESDAALVGRTVEFVAEEPIELVDCRVAGGSSIFGRCTVIFELTRPSLAVQGSSSTSDLSPSFVLKVQHINHKSKGCEANVLDKIVRCCASHGAASASSLLIERHVALPEKAASLGLHRSQMDDSALPVLMDPDYPDRRQQESSRRTLDVLVVRNPTPLPIRVDTGRGPQHKFSQACEVFDQLLTLLYVLWDLGIHHRDLSLGNILHHQGHLVLVDWDTGVVAQPGTRVPIAADFAGSFRITEATASYEILACPPGLLSGGYKVPSHALRHDFESSVYWFLHVMDWYVGESVSAELWEELQLRPLANEPTFSPALIRLELWDEGSFPELRQEFLQDLANVDTELHDLVNLITSARPGRLPPTARSDRQHYRCVKQKMVKVQAALRRMLEEAQQPDYHGVLGRYHRLLKLQYETGTLLTKLDALPHDPPSLVPHIASRTSCKRCQASTEPTFLSAASYAFSLAKRTELLLYDPIWFLCPICVRSATDNKGALVRSFAIGRTAVRMINQTEFFELRLPTAMGADIDHVAPTQAARLSMAPFYDSLRARLVILGERLQSKTVATMPEPPTTPLEGPVKSISTSRLGRHDPRTRKRTDRVDSLSETRRRINSPPPPTPSTHDLLQRPQALVDQNAQECLRFAESKSDQARVAAWEQKYAADLDGVPLETPACSAGLFVDPIVHIFPVDSSVMVREGEPSSFIALTFQEEVDTPISVPSPTSVQVRRQGDRIRRVPDHRPSIRPITRRGSNRVRGLASSIQNCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQS5</accession>
    <name>A0A2X0MQS5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C027g10287 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C027g10287</name>
        <name evidence="3" type="ORF">BQ5605_C027G10287</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQS5"/>
    <dbReference type="STRING" id="796604.A0A2X0MQS5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ28219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="312" mass="34407" checksum="8CDA00F63DB9F2E4" modified="2018-09-12" version="1">MSPDSRDTPLHMETPARRVKLDMPLLKAGSKSRDVARWLAGCEDAVESAEWNYGKIATVHLIREAGSRMEGEGGDWYIDSRDKLKALKTWDDFAAEVKARFVSEKTGLAAEHAFFNAQQSGTFNEFIALLTQERSQAGLASDGTQVIPDELFKRQLLHRCDELLYLRATASPSFALDKFSVNALVAYLQTMWDAITLERATTGMRRLNLRHERGEPTQAVGPRTPRLEGAAKEKAMFEGRCFVCDTVGHISSNCSSKPNTASPRRDPPGSTPGPRMVAAIRAYEDTGDSTAFVGISSDSEDDDERLFASEPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MR68</accession>
    <name>A0A2X0MR68_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C026g10274 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C026g10274</name>
        <name evidence="5" type="ORF">BQ5605_C026G10274</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ28083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MR68"/>
    <dbReference type="STRING" id="796604.A0A2X0MR68"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="295"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGZ28083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="378" mass="40932" checksum="AC9F5231FC9908F0" modified="2018-09-12" version="1">MDSSPASPLAPRDPSSPESSIGEQIATLQAQLAALQASQPAAAAAATPAVTAVPGNAATASKVVFPKHARLDGPKSFTNWLRQLRLALPNQVRGYVLDGVMPPTWTADQLAARDDAAREIIVGSIDSADVSATLDAIPSDDLSAPRIFAALKARFAPDDATRTLELFARLWDFRKMPASVEAYDTWLREYMSIAQEIRDAKTSLNDVLATHVLAMVPSCLDSFRLTFTDEQRNRRDLPELTTLTDRIRIQLRSAGLSTSHSAMLATSSPCPACRAPGHRLRDCTSRAKHPPTGPCRRCHKKGHWALDCKNRGEQARSSDDTQDNTSSSAALQPNVGYFASCLFARRQLPTDTFVVDSGAKSDESLQHTYSINSTTSAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MRR3</accession>
    <name>A0A2X0MRR3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C001g00772 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C001g00772</name>
        <name evidence="1" type="ORF">BQ5605_C001G00772</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY49353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MRR3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY49353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="168" mass="18965" checksum="865C3FFF42C36664" modified="2018-09-12" version="1">MSVSERLDSDQRFFDDLVEKSEAIISITNSSRSIGYRCAVCSRHKDRRLSLAQARAHFKTNVHKEQVQLQGIGVGDPTWVSFPNNEATSRNICDWASYLWTKYVEPTRRSAAASKFGTAKDSKDWKQPLARMQTTKDDAQSQMFLLVAKTTRHLSSCKESQLTASTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MRZ7</accession>
    <name>A0A2X0MRZ7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C001g00862 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C001g00862</name>
        <name evidence="7" type="ORF">BQ5605_C001G00862</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY50198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MRZ7"/>
    <dbReference type="STRING" id="796604.A0A2X0MRZ7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF16">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY50198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="240" mass="26601" checksum="0EE25589CD46BA43" modified="2018-09-12" version="1">MTASIASAGSKRAEPMDKNMTAHNECAKHADAALALSEERVTVTAEDVRPTERVQRCLFAAVLNRNYDDEQSRRICRKTDIHILLFLSWGKREGEIFSDKIIVGLSAVFGLRKQVGLVGNQYSNIGNIGYYAQLVMQPLAAYLLVKVPLRRFVPLIIFLWSVSLAGMAASKTYRAMLATRFFLGVFEAAVLPAFMMITSAFYRRSEQPVRVAIWYGLNGLATMVSSAVVYGIGHIRSSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MTG5</accession>
    <name>A0A2X0MTG5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C002g01417 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C002g01417</name>
        <name evidence="8" type="ORF">BQ5605_C002G01417</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY32860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MTG5"/>
    <dbReference type="STRING" id="796604.A0A2X0MTG5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF20">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="78"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="653"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="661"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY32860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="696" mass="78003" checksum="F8AAFA7F161D7A9A" modified="2018-09-12" version="1">MQRDQTHHEPMVRPGPEGSNTRTQAAPNSTALSALSSYSSSNPPVSQHSIPAAVHAAPRPSSKPGADAAQETPKAEKSCRGCRQRKVKCDRQWPKCGRCTERALDCQFSNLVPANFARTIDHDALVSQLEKRIQSLESELVAQSFFLPAAADLCSSISTTFAANAASPEVALRFLSQREEDEERLAKVKRKSGTAFDDHSDLDNGPTPGSLSLEVRLAKPTLQRSFALHLLDAFFDSCCSNLPIFRPFLIRKSHLYRQIDDLDPPSRVAVATFCALGVRATPHSGLLGIPEVDPSDSRAMIVSGVRREQTYKALHAEAMELSDRLEIAHDPSQPALEALMVQMQALMWQELIPRRSRSMVRSALGMFKDLGEQRAALVKSIGLPLLAGDAITSAYGRRACLVTEADLSEYFSGLVLPDLEYDQLQSMIAVRLRPGEEPNHMQLSSASMVIWRWLIACQREFNRIASLHTVHYSMITSEIMMLWTALDQIHSAIQDFQSLLMGLRGLPPGCEADGCSSMHLRYVTRLDREVDDLTWLIQSLISERMQGHHGSHDDLSGEWLLESERRVRRGLKLAAFYFELYSISVSPNQTWYLCWQLELMPRWTSIAVQRYGEEGGPITPDDELTETELDWIEKGLRVAAYYHPVAERRLVEMQSIRRPPRRDSAPSRATQDRPDLLLEEAMRRTIMSTAMPFPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MTH5</accession>
    <name>A0A2X0MTH5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C002g01427 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C002g01427</name>
        <name evidence="1" type="ORF">BQ5605_C002G01427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY32961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MTH5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY32961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="208" mass="23351" checksum="751553506CC08DAC" modified="2018-09-12" version="1">MASMHSSSSRPSVPFASYGIRNIGMVLLREPFEVPHARRVHAKLVDEQTGRAIYFTQHRTTVYEAALFMGREKINLDAVHGPGSFHRIGQCSEEDLEFRDITVSSQKLYKSGFFSNKTRSWKAPDGLKYSWLTGEDGSLRLTQNKTHSAVVSATDVGNGCTRIVISTQVIGFVELVLLTMLQQEFELSKAHKKLLKEAEDQDGDLCVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MU90</accession>
    <name>A0A2X0MU90_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01687 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01687</name>
        <name evidence="2" type="ORF">BQ5605_C002G01687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY34819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MU90"/>
    <dbReference type="STRING" id="796604.A0A2X0MU90"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013248">
        <property type="entry name" value="Psh3/Shr3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28228">
        <property type="entry name" value="SECRETORY COMPONENT PROTEIN SHR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28228:SF1">
        <property type="entry name" value="SECRETORY COMPONENT PROTEIN SHR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08229">
        <property type="entry name" value="SHR3_chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00786">
        <property type="entry name" value="SHR3_chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY34819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="233" mass="25168" checksum="3CC15201EDA18672" modified="2018-09-12" version="1">MSGNGLASIVSASFLLGVLFTTIVWDSSLLFGKQILTEGTVTAVENYYLTWWNAEMTVKVILHVVVGILFMSLVGKFARKSETAYYFSGASLLLMILVASVYIVITVPSIRLIAQDPLDKSILASSIPDTFTRLQAYFAKSNTGPLGDRARNAAAALRNAEPMGWDKRVEHNSVLCAGNTIIAALLVGVVVLQISEWYVEEQLAKENAELAAQGLAPVVAVEAVAVTEEKKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MUK1</accession>
    <name>A0A2X0MUK1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C071g12879 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C071g12879</name>
        <name evidence="3" type="ORF">BQ5605_C071G12879</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000124">
        <property type="protein sequence ID" value="SGZ34402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MUK1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="178"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ34402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="673" mass="73462" checksum="DF2A8483AF6F538F" modified="2018-09-12" version="1">MLERREAFGDLNSTFTLPQGLPSSVALPDPESPASSASDQGSSDSAISTPCPSPRPVASCALPAPPSPARSDSPDPIDLLPRPRDVASLCQAQEFPDDVDDALHSPSAVAYLASGAAALIETSPADPAELIAPARDPPHWRAAMATPQADEWRLAARDEFDSLLRDFSAFTPIDESLVPADAKVLGSRFVFRTKRDQHGQVKSYKGRLVARGDSQRSGIDFDETFAPVAKFTSIRALLALAAAHGYHIHQADIDKAYLHGKLDAPLYIRVPDGIYMPGKVLQLHRSLYGLRQAGRIWNDEIDSALSALGYVATESDHCVYVRTTGDVHHYIALYVDDLLMISPSLPEIERTLQGLEQRYGVKRLGEAEYVLGIQIRRSPDGSISLSQEQYLKDVLARFGMSDAHPVATPMQPDLRLEVELQPTPFPDRTRYLQAIGSLMYASTGTRPDLAYTVGYLARFSHSPSAAAWGAVKHAFRYLAGTLSHGLRYARGNPAPLLGYSDCNWGACVLSSKSTMGYTFVYAGAAVSWSSRLQSRVADSTCDAEYLALSQAGKEAIFLRQLFGELGLSSSKPVLIYGDNQGANALTKNPVFHARTRHIRLREHFVRDMVSMGDIVVQYINTGEMTADIFTKALSRDLFARHRGRLVLEQAGQLAPRFSLSCSSNFIGLVSLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MUT8</accession>
    <name>A0A2X0MUT8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C065g12800 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C065g12800</name>
        <name evidence="25" type="ORF">BQ5605_C065G12800</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000133">
        <property type="protein sequence ID" value="SGZ35219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="1100"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="2039"/>
            <end position="2223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="588"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1367"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="2936"/>
            <end position="2974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="23">
        <location>
            <begin position="1374"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="1415"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="23">
        <location>
            <begin position="1442"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="2955"/>
            <end position="2965"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGZ35219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2974" mass="325622" checksum="6DE184F5E4399788" modified="2018-09-12" version="1">MDDTSPPLATGVHPTFPADQLAALTSLLSGLTAAASGTVTTTTSSSTTRPAFPKHARLDGPKMFANWTRQLRLCLADDIRSYVLDGIVPVDWTPSQRSARDVVARELLANSIDSAEVSAVLDAIPTADLTAPKIYLTLKSWYAPDDATRTLELFSRLWSFRPMPGTVGEFDGWIMEFKAIAQEIIDTKTTINDVLATLLLAIAHPSLESFKASFTDEQRTQRSLPAIDSLADRMRVQLRSTNVPSTQSALLASSSSRPTRPKCLACHSPSHRVAECPVRAKHPPPGPCRSCKQNHWSFDCKKALENGKKADTANSTANSQHHVGCIATGFLARRRQLRTNSFVVDSGATSHMVSDKSLFTTYRHIAPTKIGGIAGGINAIGTGNIAFVAASGHPITLTGVLHTPGLFVNLLSVSRLCDTDDVRVAFTKHGIDIDKNGHNIAEGTRLDEGLYLLDADHSKCQHIALLSRSQSSVPLLTLHRCLGHLAPSSIQKMVAAGLLEGLRAGYSDEEVEKFVCNACLSAKGHRLPFPDSDSHSSKRLGLVHAGQLAPRFSLSCSSNFIGLVSLRGHLRARPRHFFFRASHGSAPPTLRTPGMSDSDVPKPTTLTVPPPRPPTQITAFAASDLLRDADGYQDWVLTLCSRMPSDVIDYLKSGVPPTSWPPAYVPLWDHYARASICAAVDPRLVLPGLSQYFGDTHSGHKIWAALRTRYGAVSAVDLLPVISRLFSPDLMPDTADAFLQFRDRFENDSRLLNDSDVTTDSLLASHLLARMPPSLSAWRTTFVNSQGTSRTLPHAAEILDRIYREIKARPIDPLAAATVTATSPQRTPPSPCPNPTCRKMHWLRDCPDTTWAAAFRARKAASGTTSRAHKKGFRTIASPAVTSPTDTERPEPTTFTACLLATPSAFPKSAWLLDSGANRHMANDSTLFSSLRPFTGPHVAGVAGSLPSTGCGSVRLSTSAGPVVATDVLLVPSLPCNLLSVRRLDRLGFTVSFGSGHAAIRNSSGTVVATARAIANDLYALNVAPSTCMPNALLATPHRVSLLTLHRRLAHLPVAQLKNVVQKGLVTGVDWVYSEEEFRSFHCNACLASKAHALPFARSKSIAPGRLALIHVDVAQMPRASFGGHRYMLVIVDDYSRKQWCLLLTYKSDVFHRLRDWILEVENATGDRVKTIRSDNGGEFTLRTFVDFCVAKGIRRELTIPYTPQQNGRVERTNRTIKEGILALLYSAGADTRLWAEAAKYFVHCKNLLPHAGIHGEVPDTRWYGMAPDVSSLRTFGCRAWHCLPSVKRTDLDPKAVPLIFVGLDDHAKAYRLFDPATRKILLSRNVVFRESEFPALQPAANTTTGATPLPVAAEVYPDQVDHSEPLLVASPRSPAPRAAPPGPAPVASDQGLRRPSPGRAVPDQDSHAPPASDQGPSPASDQGSPTASDQGSSDSAISTPCPSPRPVVPRPLPAPPSPARSESPDPIDLLPRSSDLASFCLAPEFPDDLDDALHSPPPVAYLASGAAALLNNAPPDSTELIAPARDPPHWRAAMATPQADEWRLAAQAEFDSLSRDFSAFTPIDESLVPADAKILGSRFVFRTKRDQHGQVKSYKGRLVARGDSQRSGIDFDETFAPVAKFTSIRALLALAAAHGYHVHQADIDKAYLHGKLDKPLYIRVPDGIYMPGKVLQLHRSLYGLRQAGRIWNDEIDSALSALGYAATESDHCVYVRTAGDERHYIALYVDDLLMISPSLPEIERTLQGLEQRYGVKRLGEAEYILGIQIRRSDDGSITLSQEQYLKDVLARFGMSDAHPVATPMQPDLRLEVELQPTPFPDRTRYLQAIGSLMYASTGTRPDLAYTVGYLARFSRAPSTAAWGAIKHAFRYVAGTLSHGLRFAHGASPPLVGYSDCNWGACLSSSKSTMGYNFIYAGAAVSWSSRLQSRVADSTCDAEYLGLSHAGKEAIFLRQLFGELGLSSSEPVLIYGDNQGANALTKNPVFHARTRHIRLREHFVRDMVSLGDIVIQYITTSEMTADIFTKALSRDLFARHRGRLGAGQLAPRFSLSCSSNFIGLVSLVLVRIIVHSDVLSLPERSLTGKRYLVTFLDDYSRKLWAYAIGHKSEVFSVFKTWLAEVELETGATLKVLRTDNGGEYCSRAFTDFCKVRGTRRQYSIPRTPQQNGRAERVNRSIVEGILALLADAHLPKTFWEEAAAYFVYCKNLVQHSALDKATPNSVWQGGCTTASALHPFGCAAWLTVAPELRSKLDPKAVRVLFTGYDLASKAFRFYDTTTKKVTLGRNATFVDTEFPGLCGDSAEPDDDTHFASAPFADPQTTVKSWTPLYSVDPLDLIGSQPQAALDPMDTQPPDFSTYREPASAEESPDELDLIGRHSRDESPDEIDFLTRHHRAFIATDDDTSDTEAIEPVKSITSDPQTWREAMSGDKREVWAKAAADEFNSMRDNFKVFTIDDRSTVPAGATIVSSKFVWKTKRNALGEITGHKARLVAQGNRQRDGIDFTETFAPVARFSSIRSLLALAATNGLHVHQADIDKAYLHGDLDHDIWMTAPRGFDLPGDKVLRLRRSIYGLKQAGRIWNRHIDASLRDLGYTATGTDHCVYSRLDDRQRPHYIALYVDDLLMISPDLAEIERVISGLEQRYGVKRLGPAEYILGIQIRRLDDGSIALSQERYIMDVLARFHFDTTTRGTTVPMTPGLSLTAIPGQATERIRSWYLQAIGSLLYISLGTRPDIAFAVSYLARFANNPGHRHWIAVKHIFRYLRATYRDELVYARGEARITGVVGYSDANWGACVDTSISTMGYVFYIAGSAVSWSSKRQSRVADSTTDAEYLALSHAGKEGIYLSQLLEELHVQPVAPAHIFTDNEAAAAVARDPVRVTGTRHIRLREHFVRDMVNRGDISLSHVGTSDMVADIFTKALGPKVFSTHCYALGLRTRHPRLGSASHSRGGGVKSPLSARQRRLGRRAHPLARPLAVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MW08</accession>
    <name>A0A2X0MW08_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C003g02389 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C003g02389</name>
        <name evidence="6" type="ORF">BQ5605_C003G02389</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY40513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MW08"/>
    <dbReference type="STRING" id="796604.A0A2X0MW08"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22926">
        <property type="entry name" value="HFD_SPT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF16">
        <property type="entry name" value="TRANSCRIPTION INITIATION PROTEIN SPT3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="292"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="292"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY40513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="476" mass="53157" checksum="11C7A27CCB6D3C2F" modified="2018-09-12" version="1">MTSTPTNGSTSTSLSSSTVPITPTTRYSVEIAQMLFVLGRRADVDRDLDEEVLVYLEQIVQSQLVDMVTEARSLAARRVGSTSSGTGLGSSSTRQLQVDDLMFLIRHDATKLNRLKMYLGWKDVRKKFKESDQDDEPEVMDEPVAVADRSTSERAYRVPNKGIKLPWEITTIYGDCLPETSEDEDAHSELTREMKKQLEHADELTKYMSKDEYNFYTECRHASFVYKKGKKFREFLNLGIVIESTLTDDVLDVLGFLAFEIIRTISEAGLELRKIVTLARAENALRLLRREKEEERGRREEEGEGKRKIEGENKRGFKGKGPKEEGMVVDGTEGCEEESKMDPPPVSPSKRQRKIEGSTSTPNARESTDTKDALTKSASTSSPPRPYSIPTGLFSAPPEPVSKSSLVTTPGGTHRLGAKQIVQALVGEVATKERQALQWGDVHGGVEAWQRGRNGLKKSGMGNWRAGVQRVPSRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MYS0</accession>
    <name>A0A2X0MYS0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00764 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00764</name>
        <name evidence="2" type="ORF">BQ5605_C001G00764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY49294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MYS0"/>
    <dbReference type="STRING" id="796604.A0A2X0MYS0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.320">
        <property type="entry name" value="Protein HRI1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031818">
        <property type="entry name" value="Hri1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043047">
        <property type="entry name" value="Hri1_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16815">
        <property type="entry name" value="HRI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY49294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="240" mass="26625" checksum="49941311D8AB4935" modified="2018-09-12" version="1">MTMDPLVSTRVSIRWPPNAATEDCDVLVIQGRTGFFLDLRIFVDGHQRQGEIDWATAGWKKLLPASADGQPRASFAPLIDSRQCAPEYTPSPAADEDKSPPADEGTFTTLPNGDVLETGSMPNPDVPGSPIQEYEEVWRRLLLPKVVKCLILAREDDKVFWGRVAGWEVGMGVDYQSKFWATRRDLNGSGEWKDVVGDGKVDGKRRPLGETRAGDEDPPKEGDVITTEDGKRWRVIENST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N4L3</accession>
    <name>A0A2X0N4L3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C005g03406 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C005g03406</name>
        <name evidence="5" type="ORF">BQ5605_C005G03406</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FRG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY75193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N4L3"/>
    <dbReference type="STRING" id="796604.A0A2X0N4L3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23339">
        <property type="entry name" value="beta-trefoil_FSCN_fungal_FRG1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008999">
        <property type="entry name" value="Actin-crosslinking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010414">
        <property type="entry name" value="FRG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928">
        <property type="entry name" value="FRG1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928:SF0">
        <property type="entry name" value="FSHD REGION GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50405">
        <property type="entry name" value="Actin-crosslinking proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY75193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="369" mass="39902" checksum="93D23AFE5E8CA73A" modified="2018-09-12" version="1">MGKLTFKGEPKKKKHKSRSTSSRHDSNPTSTHDDAYTDQDLSAWIAVPEPGLALGPLYLTLPRSSITSSPVCLALQPTTGKVHPFALPVPGKSAGTSAGTSAEDSKARTSLAATLDQEELEALVDYDPSSNHNSLTTSLTTETQTPTDIHHVWVCTRIPDSQDKITLRSATGKFLAADQFGQVTAEREARGMLEEWLIEPSSNPDLPRGTVVLKSCHGKLLSIDLVAGGKVEVSADTDPNAGIGPTEEWQVWMQGEYLAKAKQQLLERTGTKATLLDARAKSAAGKGDGLTIVGNLGGAEQEAIKRFQARGQGRYIGSEEDISELAKARRKGKLSEAMLDRRVKLKRSVDEIKFFAGLFQLLTLRTVWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NBQ3</accession>
    <name>A0A2X0NBQ3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="19">BQ5605_C045g12198 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">BQ5605_C045g12198</name>
        <name evidence="19" type="ORF">BQ5605_C045G12198</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000115">
        <property type="protein sequence ID" value="SGZ31537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NBQ3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0229">DNA integration</keyword>
    <keyword evidence="13" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="12" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="11" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <keyword evidence="16" id="KW-0862">Zinc</keyword>
    <keyword evidence="16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="17">
        <location>
            <begin position="247"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="18">
        <location>
            <begin position="443"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="SGZ31537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="705" mass="77779" checksum="BCE42CCDD8FA7DCF" modified="2018-09-12" version="1">MSSGTRDRPPHTDNVARRVKLELPTLNAGFKSRDVTRWLAGCEDAIESAEWNYGGKIAAVHLIREAGCKMEGEGADWYIDCRDKVKALKSWPEFAQEVKARFINEKTGLEAKHAFYNAHQTGTLSDFVATLIAARGQAGSIGGTQVISDELFKDHLLHRCDELLYLRATASPSFDVAKFTMNQLVAYLQSLWEAITLERATTGVRRMGLRNDQVRQEQNNSAAHQTSGRPMAGLDCTPRDKALHEGRCFHCDVHGHIAADCPSKPGTSLTPAPSRPTPGPRMVAAIREYQESGDSTAFVGISSDSEEDDARWLAFQTDKEDALRLESDLVPFTLGLIIFRNTVDAHFRLRNKQFVLEASPLPPSFPRDSALNITLPPCADLPLWHGRLGHSGVNAVLASGKVGSIGLNTAAVTPDLMQLVKDCVPCHLGKDAAHCSHAPATHRATAPFGRVYMDLWGPGPVVSLSGHHYLCGATDQFSRYRWLCGISAKSNATRSFKDLIAFADVQYPGSPFCTLVTDRGVEFVNRQLDDWLASRGIVHKLSAPYAHGQMGLQERSWHSIFDKVHTALAQSGLPLFLWEEAAHAAVYTLNQTARSALDNSTSDLVLHASGDPVAEHCHPRGSRLCVWGCHALVPLLPEQRGHKLAPRSHHCFFVGYSQTSKAWRFYNPACRKVFELSQATFYGAGIWSHSQQRNLNPSMVERYDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NEG1</accession>
    <name>A0A2X0NEG1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="17">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">BQ5605_C024g09849</name>
        <name evidence="20" type="ORF">BQ5605_C024G09849</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15 17">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="17"/>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ26164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0NEG1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000039">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000028">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000031">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000018">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 17" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 17" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 17" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="128"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="418"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="973"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1053"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1086"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="19">
        <location>
            <begin position="82"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1198"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1231"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1243"/>
            <end position="1255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="SGZ26164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1283" mass="138993" checksum="7817DE946D5EA04C" modified="2018-09-12" version="1">MSTDLEKGHSPSSVSDRVDATLQDKAPQRRLCGLLAPKKEKKFVPFVFPDPTPEEMDPFSRQLTPSTLYSLVDPKSYAYLKSLGGTPALLAGLKTDPKQGLSESTGKLEDRRRIWGENRVPQKKSKSFLALCWAAYTDKVLIVLSVAAVISLALGIYQSVGAPPKTYESTRCPNNTCVEASVEWVEGVAITIAIFIVVMVGSVNDWQKERQFQKLKSVALLPRSVPCLPTCTDPSLCPLHYSAQKEERNVKCIRNGAEQLMSVYDVLVGDILFVEPGEILPCDGVFLSGHNVRCDESGATGESDAVRKAPYEELDGSEKGKTDCFLISGSKVLEGVGSYVVTSVGQNSFHGKIMMSLQGETEDTPLQLKLNRLAELIAKLGSAAGLILFASLMIRFFVNLAKIPDRTADQKAQNFIQVLIISVTVVVVAVPEGLPLAVTLALAFATRRMTKAALLVRVLGACETMANATVICTDKTGTLTQNKMSVVAGSIGVHLKFVDRLEENSARNNANDDRDPEKIVGAASEADKASIAPSATRTGRLDFQTDMSEINKHLSPALKTLLNDSVVINSTAFEGTDEHGAEGGFVGSKTETALMSFAQKQSWPHYKAVRESANIVQMIPFSSERKAMGVVVKLADGRYRLYLKGASEVLTKLAQRHVVVHENGANSNSDIETVDFNEETRGNINRTIIFYACQSLRTIALCSRDFASWPPANAAIDPVTGEVAYDAIAQDLTLVAVTAIEDPLREGVSKAVATCQKAGVQVKMCTGDNVLTARSIASQCGIFSKGGIIMEGPVFRKLTVQQRHEIVPRLQVLARSSPEDKKILVDHLKSMGEVVGVTGDGTNDGPALKSANVGFSMGIAGTEVAKEASDIILMDDNFASIVSAIMWGRCVNDSVKKFLQFQLSVNVTAVVITYITAVSSNDEESVLTAVQLLWVNLIMDTFAALALATDPADPESLDRKPDRKMAPLISAQMWLMILGQAVYQILVALVLHFAGHHIFGFHSSDSGERIDQDNELKTLIFNSFVFCQIFNMLNARRLDRTLNIFHGIHKNMYFLVIFIIMVGGQALIVNFGGAAFQVVRISARDWAISIILGLISLPVAVLIRFLPPGPWERFLIKIRVYPDPNAPLPSFTEEKKWGEGLQKTIDNLAVYSQIRGGRARGSSIIRKSRTKQLREHDIHPASLMAMIPSMVMGSVGGGWRPEGSLADPAAHDPSASTTQLFQTGHLAEGRDVLGNSIPSTGFARAGHSRSASHSSTLAPIPQGGELTTTTTADGSLAPPSPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NGV0</accession>
    <name>A0A2X0NGV0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">mitochondrial processing peptidase</fullName>
            <ecNumber evidence="5">3.4.24.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Beta-MPP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">BQ5605_C052g12578</name>
        <name evidence="18" type="ORF">BQ5605_C052G12578</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins. Preferentially, cleaves after an arginine at position P2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.</text>
            <dbReference type="EC" id="3.4.24.64"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.64" evidence="5"/>
    <dbReference type="EMBL" id="FQNC01000099">
        <property type="protein sequence ID" value="SGZ29956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NGV0"/>
    <dbReference type="STRING" id="796604.A0A2X0NGV0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000002">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000001">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF149">
        <property type="entry name" value="GH01077P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="16">
        <location>
            <begin position="42"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="17">
        <location>
            <begin position="194"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="SGZ29956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="475" mass="51850" checksum="00BDE6BEA616FD2C" modified="2018-09-12" version="1">MLARTAARTLLRSRNVIGARSLATAVSSPLTQISTLPNGLTVATEAHPHASTATVGVWIDAGSRAETDKTSGTAHFLEHMAFKGTAKRSQHQLELEVENLGAHLNAYTSREQTVYYAKSFRHDVGKSVEIISDILQASKLESNAIERERDVILREQEEVDKQLEEVVFDHLHAVAFQGQPLGRTILGPKENILSIQRDDLASYIKTNYLADRMVLVGTGGVEHSALVDLAQQHFGSLPVSANPLQLGGANSSTQTHAGKAPSQFIGSEVRVRDDTMATANFAIAVEGVGWNSPDYYPMLVMQSIFGNWDRSLGSASLLSSKLSHIIAENNLANSFMSFSTSYSDTGLWGIYFVSENLMNLDDLTHFTLKEWQRMSTSPAEGEVERAKSQLKASLLLGLDGTTAVAEDIGRQLITSGKRLTPQEIEAAIDSVDVGEIQRVAQKYLWDKDFALAAVGRVEGLADYSRMRAGMSSLLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NS79</accession>
    <name>A0A2X0NS79_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C090g13049 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C090g13049</name>
        <name evidence="3" type="ORF">BQ5605_C090G13049</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEATR5 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000004">
        <property type="protein sequence ID" value="SGY11546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NS79"/>
    <dbReference type="STRING" id="796604.A0A2X0NS79"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040108">
        <property type="entry name" value="Laa1/Sip1/HEATR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046837">
        <property type="entry name" value="Laa1/Sip1/HEATR5-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057981">
        <property type="entry name" value="TPR_LAA1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663:SF0">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663">
        <property type="entry name" value="HYPOTHETICAL HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25468">
        <property type="entry name" value="HEAT_HEATR5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20210">
        <property type="entry name" value="Laa1_Sip1_HTR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25808">
        <property type="entry name" value="TPR_LAA1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LAA1-like C-terminal TPR repeats" evidence="2">
        <location>
            <begin position="924"/>
            <end position="1072"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY11546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1087" mass="116732" checksum="DFDF9220DC6B13DC" modified="2018-09-12" version="1">MRDIIKDALLHPDAHLRAAAAESLGRLSSLGETSFMATQIQFCVNQVVSNTDPDNRAGCALAFGEIYRHVGSLAAGPVLKTIVDVLLSLSADPHPLVHFYALHALSLVIDAASLSYAPFTNATLGMLSKLYTQDTHEPEGGTPGSVNLRGDLPAYQRFLQDSERVRDLVLLLLREFVNEEDDGIAVEAIKATQHLLMFAPDALNRQQLVATLRGHLSSSSRHLLKVAAVNSVYQLVQRDAASMSKVGGDGMVQQLFELLDDDPSIEGVRDAITSWLRQTAEANPSGWIDLCQRIMSRSTGAAKAVATAAAAASSSGGGGGADTTNAQSSFADEEIQGLGLDDGGLKASKATSRWRTQLFALQCLHEVFVTVAKSGRREHFDIARARVVRANRRGLLITRVGDLIKMAFTASTAQVMQIRLEGLVVLRDVIEGFGQSQDIDFEEALLLEQFQAPIAAALTPAFSADSYPEVLASAIHVCAVFVGSGVVKEIDRMGRILKLLTTALESCRESDMSSIGDVQDLSSTAAVMLKTSIFAAWAQFQSPLEEYARVRTDPDATSSDSGAGGAAFDSVYSGLSRETALPFYERSWPQMLHAVGTLLKAGNAHMLRAVDGKPAEYFWVLFGLSYEALCATPPPAGTTSPLEVQTIALEALAGLIRPQVSGPALVEKGLFDEVCNLCYRLAITEGPEVKVHVMDIAVQMARNYEGEGVESGESSLAEDSKMRRCLQIATCVLRESVPSTSSSPKRESRARYTCSSDLALTQWSFFSTQSATLASAPARITLLRSAFSSFADLADIYPASTREELYAIAFYFYSQLLQEEASEIDLVSPTLPMLKALCDRSQRFPPGARGFVVLPKVINGMLSACLQNIDSVRGRRGAAAILKTRNNLLAAVLLLTSLGPSIQVGQEVVEHACFIITSIALSPSSEVLPTALHCLTSVLAAASRGSGVLRYCVGQILPTLIEFVAKASRTELQAGDPALVQLAEVLKALVVVLTGVAIDRRTQSLSILLPVLILLLKPSSPSASHTLAIKHLIQLASSNSSSFKEATFSLSEEQRTTLETSIRAQVGGTRRVEVKEEAPKISLKMFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NWV4</accession>
    <name>A0A2X0NWV4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C012g07001</name>
        <name evidence="9" type="ORF">BQ5605_C012G07001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7"/>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NWV4"/>
    <dbReference type="STRING" id="796604.A0A2X0NWV4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000003">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="8">
        <location>
            <begin position="146"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY16818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="341" mass="38898" checksum="AF364A0CB1F5A9B2" modified="2018-09-12" version="1">MTIIFATQDHCFRPSTLFNHCFADAPMHILHTSCSDMAVPPIFTGIAHLTDCKQLTEMDVKRLCDKAREILVDESNVQPVRCPVTVCGDIHGQFHDLSELFRIGGNSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRDRVTILRGNHESRQITQVYGFYDECLRKYGNANVWKFFTDLFDYLPLTALIDDSIFCLHGGLSPSIDTLDHIRSIDRIQEVPHEGPMCDLLWSDPDDRCGWGISPRGAGYTFGQDISEAFNHNNGLTLVARAHQLVMEGYNWSHDRNVVTIFSAPNYCYRCGNQAAIMEIDENLKYTFLQFDPAPRLGEPLVSRRVPDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NYQ6</accession>
    <name>A0A2X0NYQ6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C003g02386 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C003g02386</name>
        <name evidence="3" type="ORF">BQ5605_C003G02386</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY40497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NYQ6"/>
    <dbReference type="STRING" id="796604.A0A2X0NYQ6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886:SF53">
        <property type="entry name" value="ALPHA_BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886">
        <property type="entry name" value="RE40534P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="2">
        <location>
            <begin position="35"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY40497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="286" mass="32317" checksum="BA8E2291CCF1F5AC" modified="2018-09-12" version="1">MQDMSQVTIRIPDQGKGDLVGILQRANPAESTKEQKLALILHGVMAHKDQVYHKLLADRLASERGLDSFRYDLRAQGGESEGRWGMANFGDDADDLAVVIAYLEKEYAYRIHLIAAHSRGSMLSAYYLSKRPHPPIPLWINISGRYDMSRIMVDKRYGEEFWEKGEHLWKVRVRGKDIAQRVTREDVIAFASWDNSYLQASFPQDVHVLTVHGTADPVVPVQDAYSYHKILSQRSPGTHTLSIVEGETHNYTKPFREPVNSIMSWLEKVDGKGTPSTSDGPGKARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NZM4</accession>
    <name>A0A2X0NZM4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small COPII coat GTPase SAR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Small COPII coat GTPase sar1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">BQ5605_C016g08231</name>
        <name evidence="22" type="ORF">BQ5605_C016G08231</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 21">Belongs to the small GTPase superfamily. SAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY21384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NZM4"/>
    <dbReference type="STRING" id="796604.A0A2X0NZM4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00879">
        <property type="entry name" value="Sar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000161">
        <property type="entry name" value="Small COPII coat GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006687">
        <property type="entry name" value="Small_GTPase_SAR1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45684">
        <property type="entry name" value="RE74312P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51422">
        <property type="entry name" value="SAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10 21" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 21" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="13 21" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14 19" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 21" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="129"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606687-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR606687-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU003926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="SGY21384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="189" mass="21245" checksum="B3594E975692B67F" modified="2018-09-12" version="1">MFIINWFWDTLAQLGLVNKNAKILFLGLDNAGKTTLLHMLKNDRLATLQPTLHPTSEELAIGNVKFTTYDLGGHQQARRLWKDYFPAVDGIVFLVDSVDAERFHESKAELDALLAIEELSKVPFLILGNKIDAQGAVSEEELRYALGMHATTGKGKIPLGEMRPIEVFMCSVVMRQGYGEGFRWLAQYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P090</accession>
    <name>A0A2X0P090_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C001g00491 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C001g00491</name>
        <name evidence="4" type="ORF">BQ5605_C001G00491</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY47051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P090"/>
    <dbReference type="STRING" id="796604.A0A2X0P090"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025715">
        <property type="entry name" value="FoP_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13865">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01218">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Chromatin target of PRMT1 protein C-terminal" evidence="3">
        <location>
            <begin position="129"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="113"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY47051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="200" mass="21247" checksum="82DD62AD6F01D12B" modified="2018-09-12" version="1">MTHDDRSVSRTACLDSSCLDPHSSLNVVRCPLEVDGLRFDGRGGRGLAERGVVAVPRRRRPRGSRSQAGSYHRSTKISVLQFAHSPHKSGSRSKQRSRYFCRPLKVEIIVDPNRVPPQPLTSRLGAAPAAPPKTRVASSTVAAASGASGAARQQTRATGGRGRGRGGRSGERRAKPTVESLDAEMSDYLAQASNVAAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P0D3</accession>
    <name>A0A2X0P0D3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C018g08656 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C018g08656</name>
        <name evidence="1" type="ORF">BQ5605_C018G08656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY25692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P0D3"/>
    <dbReference type="STRING" id="796604.A0A2X0P0D3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY25692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="731" mass="79216" checksum="E942355C3D8503ED" modified="2018-09-12" version="1">MVSTPLASASHLLNGVDSAPPTILSLAHSLSTSISATFDRVCSSTSSSSCSMPSSSTRFLHPYGPLDPQQLSSTRQHVSTTLTQLRQAIESFNSLLPPPPTPTSDHSTSNQATAVAPNASNTVKPHAQLDKYLSVLKEASTHQGALNHWLSTELEIAKRIVDAHTNEDSVPVAIPNELGSIGLERTVQVLQGIAKGLGLVSFREGGQEEGEKLAMTMTMPRAETETLSLGGKVMVVDFIISTKRGNVDKVNVSYVMDAGQVDLTEAAGSLQKCVSLLGDEEGDAHEEAGGKALQAGLRGCRRILRELTSLDTMTEQSGVDAFLAVERIEMACRLVLSPGQAEGQACSQTTSKPVDPTRRGLLLPRTRDHLPRMVYHATPLVQMTNTWTQASMSNFEQDLSDLLSLDGISTVSIHLEKPNKATLIPSSYVDLVEEETQGDSTTTMFDPPAVKKIRYRVLDKCTAPWFVARFDGGVGITKEVGRRLREVLGEVGVGVGSGKGKGLGMEGACTLDAVLLSQRPMERVDAVDPSARYKVSFDDLPMVQEYALDTSTRVPGYLLTSIRFRAPEQLFKALKIIQAQARINALVRSVFHPRYLVPKSGMNNEVLDGALRTKRRKLEVEVPITLEDVLAQMLTHSVIRLIEESTRSTLPIFVQIKSDSSLSLSFPHPSGPAELAKPTALRISSTSSEEGEEGYHLRFEGLEVDVSKAKEVLDLTGDLGLLMRWAMKTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P0S2</accession>
    <name>A0A2X0P0S2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C001g00771 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C001g00771</name>
        <name evidence="4" type="ORF">BQ5605_C001G00771</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY49348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P0S2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013177">
        <property type="entry name" value="Ribosomal_mS38_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08213">
        <property type="entry name" value="COX24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01155">
        <property type="entry name" value="DUF1713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein mS38 C-terminal" evidence="3">
        <location>
            <begin position="482"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="305"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="479"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="237"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="487"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY49348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="515" mass="56139" checksum="9EB1722D301781E2" modified="2018-09-12" version="1">MLRIPTLPVVRAKAPTPRFFNPSYRSLSRPQLLSSDLLAQQSTKSAAQRRCSFSSKANGSNSSSRGRNSARSATAVKQAKRADATTATTATTSASTATTTVHDVAASPASTLHTTSAAPNAQQLAATPRPAHALATLPHVTPSLVGLDSFFAAGRPLLELPIRLDLRKSTSPANSTSYTTLEALIKASETDGQEEVSVADFEGDSELAEVVDLGPDGKPIGAPYFTMVGERKPIEPLRTAEEEREIELKQADEAAQEHEQTMRVLEENQDDPYDAWLIGEREGTEHATSVARYLAAQSPFVAPPPPALVAESTSSTKASPHSPQTLSNISYLRPFEPKTARTAPQSSTPSASPLSSPSSLFATQLANPLSPLEARKHTERFLSSASFLHRWHAERDFHALVSNKLERAARSYAGPSGRKQRSRSSFSSFQNGRLRLWTTQSKGWQVADFKANGPNGVFLAAEMVDLDWVDEADAANSHEEVQLDSTRRKRKKKITKHKYKKRRKAQRALRQRLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P111</accession>
    <name>A0A2X0P111_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C002g01029 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C002g01029</name>
        <name evidence="1" type="ORF">BQ5605_C002G01029</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY29234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P111"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY29234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="177" mass="20121" checksum="3D6CAA3C92CB0693" modified="2018-09-12" version="1">MKSEEDLCRPEIVVSRELVKMTTTPRGRAHAIASIVEFGPGRPRGRRLATFDSSPISLPRPLREQAEQRLALRTTPLDRPQHNLLVAPQPSKPTTHLVNHLATPPFSIFERHAPPRTMFAPFERLRLTPSMGSLHPNQTTPLPPLPPPIPRIHNLPIPRFNLNFFLYPTRSNHFQPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P359</accession>
    <name>A0A2X0P359_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g01981 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C003g01981</name>
        <name evidence="1" type="ORF">BQ5605_C003G01981</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY38225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P359"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY38225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="87" mass="9410" checksum="0112197126D4E50E" modified="2018-09-12" version="1">MSDDALKSSTLAVPPPRPPTQVAAFAASDLLRDTNGYQDWVLTLCSRLPSDVIDYLQSGVPSSSWPPSYVSLWDHYARASICAAVDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P5A3</accession>
    <name>A0A2X0P5A3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C001g00106 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C001g00106</name>
        <name evidence="3" type="ORF">BQ5605_C001G00106</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY44047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1061"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="449"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY44047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1854" mass="203295" checksum="F3D92FA198A8B881" modified="2018-09-12" version="1">MPDPPGAQAPPPDNPLGGNRASDDESLNTLTREPVTGGTANPPAWSTEATQARLDCEKVMQNTFRVLGIVPSGKSTRRLMVLMHDASTPPSQAPLLARAAQRAVRNDAAPASNVIRVIMDGPGSPRGPVQIALRKHFGLAETPFMFARPEGVVLDPEVEKLFSKCVKLNPIVTKATKRFPIARHMYELVFESDQACLEAAAAGPFSHHGKEMVTELPSASPLNHVVQVRFTLPSSSSATPASVLRQSLDDALTLSFGRAGRTQGYTLMQLQRGLAVDPNGDPMAMTEDGFHCAYLRLHADLFQGSTETQKAALNAALPQEIEILGAKYGLRHEFETHYCAVCDRAGHQWGACRKPVSTPATAAPVPGASTSTSTTGFRVAGKNGKHGGPAALNSRASGTNMIQLGPRANPAGAATGNKDDANDDDGGGESVASTEPEGGDTGKETLTRATTGPTKETQTTTAAPVSTPTSPSPSASAPASPLSGGTSESSATSTTSIASTSPRRLRSSSAPGNRRVTRAGSAMILGASGGDGSGGNSSGVNQVKIIRYLKTLRPAPAAILLQEHHLGYNASREGFESAWPGACIRFTPHVLTLIPDGSPLAGHLLSSTPVVFAGAPRFDGRILRSVFRLEELDVEIINMYAPVQEDDRRDFFGLLHFNAPRPKTLRILAGDLNDCPDVSVDRVSITDRAWTPVSHWQTLLSKIAFNALDTVRHVHSCTPAFTRPHYRGRGEERKICSWSRIDYILVQCSWANRLLSASTLFDAPCSDHRPVVATFALPTSNADAEPPLSLPSTSDFISRLNPTVFDDQDFVASIPGVVDEVYRRLEGTAPLGDVYDAALRAVAVAGHARYRSTRADMRRLRAESQSVMEALEARGEHMNEAERDAYAFAKSRLDQLAVKEAQWLRIRAHVPSVDSREGQSASIRTRLNRRSRQTSIVSLEDVDGTETVDMQEALGIASRHAQSLFTPDPARGDPTNARRSLLDPIRAAKCYDDDRSDPTFGRRLPRQARVALDEPFTLLEVEAALKKTDSGRSPGPSGIPYELFKALPTYFAPKLLDLFNSIWEGGKMTASLAEGLVRLLPKNKPGANLKSLGAYRPITLRETTYKVLSKVLVARLNGVLGELLPPAQHGFMPSRRSADAGSHLTLLLEKLRSLGTDVFPEGALLSLDQQSAYDRVDHAWIFDVFEAFGFGERFISLLRALYDPETLGVRYLVNGFPTDLVRLLCGLGQGDPLSCPVWNITFQPFLDALVRRGIALDLQKVWPGGPRAQLTHLAFADDAVVVVESPAALSKLETLSQTWYEATNGKTNTDKTLVLPLGPNWLRDETAQALPTVQEGESFKWCGYAFFRHGDSKLFWTHVLDRIKAKTRAAGDRTLSPSGKVFYANAHIISTVLHVLSFDIPPQWFIKAAETALTDFVWGGAGRNTVARDFVFQAREDGGLGLISIGDIVHSVALRFWDAVAGSNEAIWAPLARESWRSLVAATRDFSPWGFFSSTARVEKLYRDSTRWGAVVAAARVTVPTIKSELLTLPELLSLPPRLPSLYAEGAKHAYDDADAVAKFAQIADLYWRDEGKGWALVGHRRGFWQHSKEPALQHEHVWSRVGQLLKAKALLPKTALRPARIPLKEAPRPRCFNFFGLTRPFTIRKLRRLVNVVRFPGREDRVKRFRDGTSQSDRKRFWRWLHDRFASAVEQDTHWRLMYDVTPTRKRQHTQGHASSPTCLFCGNDAAVIETVSHYFFECAYSTSFWGGVLRILFDKLGIEDTDVDPSTFTPEQLTMGLPLLRGRGRTTSRWMWVRLACAIGFQRLHLLRWRVHQRFELDKVVAPPSLPSALRAFERDFLSRAGFVPGARDWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P5C3</accession>
    <name>A0A2X0P5C3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00126 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00126</name>
        <name evidence="2" type="ORF">BQ5605_C001G00126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY44184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P5C3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38703:SF1">
        <property type="entry name" value="ALLERGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38703">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY44184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="409" mass="44120" checksum="C4F7231846F9E4AE" modified="2018-09-12" version="1">MNKVKEIFSSDKHSTHNNSATSGSAVTGSTTSGSTNTGSTLPGSTHNGSTHNGSTHNGSTHTGSTHPGSTHNTLPGSTLPGSTHNGSTHNGSTHNGSTHTGSTHPGSTHNTGSTHTGSTHTGSATTRSSSSIPGQHVEEVAPAPSSGHVLPQRDTHLAEQDAHAANHDHKHLAAVTHHTHQKHEVEQVERERHVDRHLHHVQHHVQPVVDSKHESERHHENIVPTTKVHEKHVNTDADTTQFAALNKHQDHYKEAAADRLVVDKGEKVSENTHHHVHHVIQPVIERDTHEHHVMRPCYPFSSATHVDQVIHTKVPIHHETHEAPIVHQSVEHQPMKLSDFVAGGGDVKSKLAHENAGVLHTQDESCKRTTDGPLESLQEKLHLGSTHHDAPSTKIAQSSPAAGERRAIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P5M7</accession>
    <name>A0A2X0P5M7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BQ5605_C005g03263</name>
        <name evidence="16" type="ORF">BQ5605_C005G03263</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY73122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P5M7"/>
    <dbReference type="STRING" id="796604.A0A2X0P5M7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="179"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="268"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="562"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="98"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="219"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="750"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="179"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="162"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="750"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="763"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SGY73122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="857" mass="95379" checksum="989F838270366E31" modified="2018-09-12" version="1">MSSNKHFAFTRKRNNTHSKKRKLDAVVATHTDQAPTAAEPKPVSTKRTERAANLAWKSIALPSEFGFDEDGGLLEVDEVEGVEVVYGAAGVQFQVKDALTAPEPKNKKTKNDHVASVAKEPLYESPFPDEPLEQLPTLDTAVEPTPAPNDNKAKRKATNRTQKAELQEQPEADPHDILPAWAHLPLAPPLYRALAELKFEKPTAIQERALSVEIGAMPYVQPQDEQEGDNDSSEEENDGERIEGEEETTTSTPYISPFADEPLDESASSPNTTDRDIVGVAQTGSGKTLAYGLPILSHILRSPPSTSTEDNPTRLAALILTPTRELALQVRAAINEVAVRTNRLLPDELQDPNLNAPRKRERRHHISVVALTGGMSVEKQKRQLARGADVLVATPGRLWDMIGENDSLARAIKGIKFLVIDEADRMIENGHFAELENIVRLTRRKRQSPEDDPEEDEAGFIDDFAISTTHSRVDLFTAREDIRTFVFSATMSKDLQQNLKKRHRKFRPGRPEDGMSSLDDLLLKLDFRDPDPEVIDLTPEHGLVETLKECKVECLLPEKDVHLYHFLLRYPGRTIVFLASIDGIRRLHPLLVLLGLNVVQLHSGMQQRARLKALDRFKSAKNAVLLATDVAARGLDIPAVAHVVHFQLPRTADVYVHRSGRTARAGQQGLALQLVAPDEKQVQKLLMASLGKGTDLPGLPIDYSIYDQLKKRIEMAKKIENAQHKATKSAHEDNWLKQAAEAMELDVPSDFDFSDEEGDPANSRKKQERTRGGRKGKGQQYELKMLKGELQKMLDKPLMMRGISAKYLTTRATVGLVDQLVDGTGHDKILGFDTSTALEDLKNKKTIKKKSNKVAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P636</accession>
    <name>A0A2X0P636_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C005g03383 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C005g03383</name>
        <name evidence="1" type="ORF">BQ5605_C005G03383</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY74832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P636"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY74832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="183" mass="20887" checksum="E198BCF69DDE7915" modified="2018-09-12" version="1">MSHVGTNTQAGRLPCDQLQGPVLRPQHRIIQPNRQPFSRITQEDQSYSGRKSWRGLYPPACADRGHCCTFELDQFANRDRYDAVFVTAPTGSGKSVIFEAMYLIYGRRAVTIVGKKAVVVSEETWRDGELYRQLDDPSHTISFILISPEMHINNADWAKLISNESFRERIKLLVYDEAIKIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P6I2</accession>
    <name>A0A2X0P6I2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GDP-L-fucose synthase</fullName>
            <ecNumber evidence="3">1.1.1.271</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C005g03483</name>
        <name evidence="8" type="ORF">BQ5605_C005G03483</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.271" evidence="3"/>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY76323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P6I2"/>
    <dbReference type="STRING" id="796604.A0A2X0P6I2"/>
    <dbReference type="UniPathway" id="UPA00128">
        <property type="reaction ID" value="UER00191"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050577">
        <property type="term" value="F:GDP-L-fucose synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042351">
        <property type="term" value="P:'de novo' GDP-L-fucose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05239">
        <property type="entry name" value="GDP_FS_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00956">
        <property type="entry name" value="GDP_fucose_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028614">
        <property type="entry name" value="GDP_fucose/colitose_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43238">
        <property type="entry name" value="GDP-L-FUCOSE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43238:SF1">
        <property type="entry name" value="GDP-L-FUCOSE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="7">
        <location>
            <begin position="6"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY76323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="329" mass="37117" checksum="0B6C9CC440A85395" modified="2018-09-12" version="1">MAPNVVLVTGGTGLVGSALKYVIESEKIGSRFGKQSENEQWIYLNSKDGDLRELKDTMAIFDKYKPTHVIHLAALVGGLFKNMKYKLTFLRDNCLINDNVMWAAKEHNCAKVISCLSTCVFPDKVTYPIDESMVHAGPPHDSNFGYAHGKRLVDVYNHAYHEEFGCNFTSAIPTNIFGPHDNYDLEDSHVIPGLVHKCLLAKKNGTPFVVSGTGKPLRQFIYSRDLAKLFIWQLREYNEIDPIILSVGEKDEVSIKQVADAIVKAVGFEGEYSFDTSKADGQFKKTASNEKLMKYIPEFEFTPFEQALDESVQWFMQNYDTARTGMNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P772</accession>
    <name>A0A2X0P772_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="19">BQ5605_C005g03723 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">BQ5605_C005g03723</name>
        <name evidence="19" type="ORF">BQ5605_C005G03723</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016154187" evidence="17">
        <location>
            <begin position="23"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="18">
        <location>
            <begin position="405"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="687"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="741"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="778"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="SGY77776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1359" mass="149751" checksum="BBDD9411F1FAB49D" modified="2018-09-12" version="1">MAPLWFLSCSSNFLVWSPLVLRSETYHCLSRLLAQPSYQCGHLRARPSLYFFTLRNMSDAGASAPEAKPREPTPDAPPLRPPTHSAAFATTELLRNSSGYRDWVLAIRSRLPSGVVRYLNTGVPLESWPASYVPLWDHYTCSSICASVDSQTVLPGLSPYLDESLAAPKVWQALRERYGTVSAVDLLPVIQRLFSSDPVPVTPDLFLQFRDSFENNARLLQDSQVTMNALLASHLLARLPSSFDAWRTTFVADQGDCTAMPSATEIFTRLYRDVKARPVDTPVAAVATPQARHGCSRPCPNPSCRKLHWLRECPDTAWAAAYRARRTAEKKASQPVASPTPCTPKALLAVPANVSLLTLHRRLAHLPVAQIKNIVQSGLVTGVNWVYKDQELRDFYCNACLASKVHALPFARSKSIASGRLDLLHVDVAQMPRPTFGGHRYMLVIIDDFSRKHWCILLALKSDVFPRLRDWILEVENATGNKVKTIRSDNGGEFTLRNFVDFCASKGIRRELTIPYTPQQNGRVERSNRTIKEGILALLYSSGADSRLWGEAALYYVHCKNLMPHAGIGGEIPDTRWHGFAPDISTLRAFGCRAWHHLPSAKRTDLDPKAVPLLFVGFDQHAKAFRLFEPSTRRIQLSRNVVFRESEFPALRPAPDVRAEPIPLPVPVDAYPDQVDPLEPSLVASPRSLAPRAEPPRPVPAAPDQGPHRPAPAREVPDQDSLAPPAPDQGSPALELPDPESPASSASDQGSSDSAISTPCPSPRPVASRALPAPPSPARSDSPDPIDLLPRPRDVASLCQAQEFPDDVDDALHSPSAVAYLASGAAALIETSPADPAELIAPARNPPHWRAAMATPQADEWRLAARDEFDSLLRDFSAFTPIDESLVPADAKVLGSRFVFRTKRDQHGQVKSYKGRLVARGDSQRSGIDFDETFAPVAKFTSIRALLALAAAHGYHVHQADIDKAYLHGKLDAPLYIRVPDGIYMPGKVLQLHRSLYGLRQAGRIWNDEIDSALSALGYVATESDHCVYVRTTGDVHHYVALYVDDLLMISPSLPEIERTLQGLEQRYGVKRLGEAEYILGIQIRRSPDGSISLSQEQYLKDVLARFGMSDAHPVATPMQPDLRLKVELQPTPFPDRTRYLQAIGSLMYASTGTRPDLAYTVGYLARFSHSPSAAAWGAVKHAFRYLAGTLSHGLRYARGNPAPLLGYSDCNWGACVLSSKSTMGYTFVYAGAAVSWSSRLQSRVADSTCDAEYLALSHAGKEAIFLRQLFGELGLSSSKPVLIYGDNQGANALTKNPVFHARTRHIRLREHFVRDMVSMGDIVVQYINTGEMTADIFTKALSRDLFARHRGRLGICAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P8Q3</accession>
    <name>A0A2X0P8Q3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prefoldin subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C006g04151</name>
        <name evidence="5" type="ORF">BQ5605_C006G04151</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY56611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P8Q3"/>
    <dbReference type="STRING" id="796604.A0A2X0P8Q3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23156">
        <property type="entry name" value="Prefoldin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000001">
        <property type="entry name" value="Prefoldin subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016655">
        <property type="entry name" value="PFD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016396">
        <property type="entry name" value="Prefoldin_subunit_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR016396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY56611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="182" mass="21075" checksum="C21A44EF45E0ADFE" modified="2018-09-12" version="1">MPAQPQPQLQPQAMNARGFPKADFIEDVDAFIVGTDPDQSLQQLQETLAEYRFMENNKRQRRQGLEEKVPELQRTLAMIETLQRKKDAEQSFDTTFELSDTLYATGCVQHVDEVYVWLGANTMLSYPPSAALSLLSEKLITAQASLQNVREDLDWLREQITITEVNVARVYNWDVKRRREIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PA17</accession>
    <name>A0A2X0PA17_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cysteine-rich PDZ-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cysteine-rich interactor of PDZ three</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C007g04783</name>
        <name evidence="9" type="ORF">BQ5605_C007G04783</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRIPT family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY63193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PA17"/>
    <dbReference type="STRING" id="796604.A0A2X0PA17"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019367">
        <property type="entry name" value="PDZ-binding_CRIPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11805">
        <property type="entry name" value="CYSTEINE-RICH PDZ-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11805:SF1">
        <property type="entry name" value="CYSTEINE-RICH PDZ-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10235">
        <property type="entry name" value="Cript"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY63193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="130" mass="13435" checksum="F81B91E9683CC07D" modified="2018-09-12" version="1">MPCAKCEKALYAKGKSSLACTDVWRAAGAAGDRNTDRKIGENKLLSSKARYSPYAPAAVAGTSRGAVAGSSKGVGGVADGKSTFGKCETCKVTVARAGAKFCQSCAYKKGICSICSKKILDTSQYKMSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PAI8</accession>
    <name>A0A2X0PAI8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C004g02656 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C004g02656</name>
        <name evidence="2" type="ORF">BQ5605_C004G02656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY66308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PAI8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY66308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="37" mass="4190" checksum="8147798EB6256024" modified="2018-09-12" version="1">MWVPGADDHMRTQTRPDADCNMGDVEFRDRSPPSAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PAZ9</accession>
    <name>A0A2X0PAZ9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C004g02725 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C004g02725</name>
        <name evidence="4" type="ORF">BQ5605_C004G02725</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY66932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PAZ9"/>
    <dbReference type="STRING" id="796604.A0A2X0PAZ9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034044">
        <property type="term" value="C:exomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.120.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031673">
        <property type="entry name" value="Chs5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052827">
        <property type="entry name" value="CHS_Export/Cell_Fusion_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031669">
        <property type="entry name" value="Fn3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47351">
        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47351:SF1">
        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16892">
        <property type="entry name" value="CHS5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16893">
        <property type="entry name" value="fn3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="84"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="181"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY66932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="467" mass="49607" checksum="9252F798854B5D28" modified="2018-09-12" version="1">MAQMVDSSNGTQRFVIGKIDAGIAVLISDSVHLIEFPSLLLPAGVGPGSIVNIACTRNFAAEKEAYESFWSLQRDIYSEFGAKEPKAPTLRVRNTTQTSEDKVTLEWDKLELASAKLLQLSVWRNGQRLTTIPNPQTNTSTKLSGLALDTDYNFHLVLKTSAGTYTSPTVKTRTHTITDTSGISVCFGLIEPEAKLAEAKSALAAMKAKYSDKIQIDTTHFVATSPASASNPTGGPSVEYQKALQLSIPVVSPEWVIACQKGQTMVPISNYYIGTVNHAASISSAQLVTSTGAIPSSKPSTRRATTTTPIAEEGPSSSAPVPAVAPTASTKGASALAEEEPEGPPGDERGLDGIVPTAEGLENRRVSNPKPPRLHVIAPSQDIDPAKVDALVRETSKVKIEETVAEEEALEEPENPPDEDDATFVGDVKPVEEENPNGESTKEEDPKAGNEESTSAKASDGMEEVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PB30</accession>
    <name>A0A2X0PB30_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C004g02866 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C004g02866</name>
        <name evidence="5" type="ORF">BQ5605_C004G02866</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY68225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PB30"/>
    <dbReference type="STRING" id="796604.A0A2X0PB30"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45663">
        <property type="entry name" value="GEO12009P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45663:SF11">
        <property type="entry name" value="GEO12009P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="31"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY68225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="144" mass="16078" checksum="85E1C2D4E9176786" modified="2018-09-12" version="1">MSLQSLRTSLLHSTRSLTQTRPSHSTVLTRSSFILRRSQHTLSATPEQFKDAIKSEQTTLVDFYAEWCGPCKQLTPVLKQVIPSDSQDVHLVTIDTDDHYELASEYKISALPTVIAFRNGKPIGKFVGGRNQSGVESFLEEVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PBX2</accession>
    <name>A0A2X0PBX2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C005g03178 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C005g03178</name>
        <name evidence="3" type="ORF">BQ5605_C005G03178</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY72513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PBX2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY72513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="620" mass="69385" checksum="F540C68C255CCF21" modified="2018-09-12" version="1">MRGMSPPPLPPKSIGLPSLGRAHLRKRSLQASNTAAEVESLMAGHGASDINLRTPRSADDTVVEFGEDDQHIYLHHVSDKYKHGDKGFGDEDDSAAKSPRNPGHLMWQDKQVDKRRKNGARCLGTFLLIISAFFGWIIGIVAPPRSLKHANQLSSGRGNALNDVFDLVSGQEHSYSAPPSCNPYDEYGILNVSTNVAAENVWQPIAPRESCQPIDYMLLFREAIESGETSDAVSDDLAFAVNRTVVIYGDSVDRDHNVHFCSLVGGYLEMIGVNHTLSPPYPPGDEIPPEGCTLPEQDKNYATGAREWPEFDQSRPYICHVGHLGLRILSVFHYGFRGRTKMIESHPHFYPPATIEERFDQIVVPLVHNLAAKHNVSATPDLVSFTPGYWGLLRQAVSDDKMLLEALKNGTAAEEAQAKYDVWRTMSPDQREWNRERMNAVLRHIGRGWLDTAKKAWDGAARTPRILWRALHHIKEQHNLPYNRVQAVDQIGRSVVQQLIAEGRAAVAGSQTWTSWIAMLKNSISGTEPDIIASEEIKLGSEEEQKEAFRMGYAHRLKIDEWGALMIGQERYFRDNVHPLPLPGSYLYGNMLMQQLKMLVEEEDLPVPIQKQVVAPIRGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PCA3</accession>
    <name>A0A2X0PCA3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C005g03338 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C005g03338</name>
        <name evidence="2" type="ORF">BQ5605_C005G03338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY74060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PCA3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY74060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="192" mass="20910" checksum="B76C13DF89CEDB59" modified="2018-09-12" version="1">MFSIIRDNAERFSAGDYSIRSATTNKYLTFRREGRVGLKLQARYATVRLEQDARYGKSGYTEGYWFGTVISGCGMCGSSQYGYPGGEGKIIAMAAYSCRAGEPGRAGGEKPPISIAKRELGVSRGGQAPSYAMILLMAADFPECFTEFFHLVNCSESWTADGIVGNPVELEGQGAQETPTRRRYKSSGRSMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PCG7</accession>
    <name>A0A2X0PCG7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C030g10870 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">BQ5605_C030g10881 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C030g10870</name>
        <name evidence="3" type="synonym">BQ5605_C030g10881</name>
        <name evidence="2" type="ORF">BQ5605_C030G10870</name>
        <name evidence="3" type="ORF">BQ5605_C030G10881</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000069">
        <property type="protein sequence ID" value="SGZ09408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000069">
        <property type="protein sequence ID" value="SGZ09544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PCG7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ09408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ09544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="58" mass="6173" checksum="CD19C79A81456C03" modified="2018-09-12" version="1">MSPPRPASIVQSSAKEPTSVGSDQKNLDHRRTQSSQSVDLAPTPMWGDQPQSPASVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PCQ6</accession>
    <name>A0A2X0PCQ6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="2">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C005g03508</name>
        <name evidence="11" type="ORF">BQ5605_C005G03508</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="2"/>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY76700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PCQ6"/>
    <dbReference type="STRING" id="796604.A0A2X0PCQ6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000703">
        <property type="term" value="F:oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000001">
        <property type="entry name" value="Endonuclease III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286:SF1">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="10">
        <location>
            <begin position="162"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="330"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY76700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="409" mass="45246" checksum="83DB2CD5932537A3" modified="2018-09-12" version="1">MARTNSSPAASGSLRSTRSTYNSRVTLYEAPSTSTTTSTSSSTSSLTPIKRRSTRSSPLKQEDQAYQEGQEEVKATFNQKIKKEPSPRKPTAFVVKLDKAHPEPKRWREAYEIIREQRKRVGSLRIIAPVDTMGCEQGGRERDTAPPSEKDNRLSILVSLMLSSQTKDPVTHQAVKNLREQLPNGLCLDSLLSATPEQIDAAICKVGFHNIKTANLKKLAIRLKEMHGGDVPSDLTELLAINGVGPKMAILYLQAIGINAGIGVDVHVHRISNRLGWHKPVTNTPEQTRLNLESWLPKEEHPKINLQICKPVGPRCDLCDVAKVPRLCPSKRSVVPPSPRKTPKKAEGEEDDLPPLPHLPKVEIEVDTKAEVKREVNDGVIGVIATTAVKETEFRAKPEPESPKKPLIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PEC4</accession>
    <name>A0A2X0PEC4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C008g05118 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C008g05118</name>
        <name evidence="2" type="ORF">BQ5605_C008G05118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PEC4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY79386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="767" mass="84256" checksum="9FD475A4725686D5" modified="2018-09-12" version="1">MARGKRNKRNPKAHAPPPISEREARLQSRRTRLQVLDHLPRAAPSPPAFSATSPSAQTHILETNSIIYRKSNLDDEYEDLEPPGSSQQGLSDISVDATHSRSPVRLQSSINEVDLSPGSDKRLHEPHTRPRVVDYSLLRSASSMTLFQEDNPKSLEAPVFPEPRTFGATIDRGTVASSPDGWTGSISVEVRDDAFDHAHARTESRMSEVEPERTARVRHSPSSHRFSVASSICSSEGSSTHDSYGLLGYKTSSPNMEGHRAFNAQLRYQLAQSSALPSEIALGKVDLNFNDVISSVTERLSPRVLRSIVMGSTIWPSPSQFQPTTCGVTAYDYNGDLFLSLRDVFTGSRNMCLWKGTSPPDDVCGRYSRGTFSLSGSQNIIFETDVFSQLESASPADTTLLSSAQFIRLAKGAAASDPPQLWIQMFSTEAQRREVLGALLSITVDPPPICHSRDPVVLRASATDPKRRGALITTTCPPQTDVLEPGSCPKSTPVVGANDPAPHAAKAQDHTDNPATLPFCLRLDASGPPLLDSFFSGLKPEESRNVYVPNGTWTIPIRVERHGLNTSPIIQPIFSYSKQSGSRYRKRPHHIKYPHLSKKVKAIKSKCLGVYVCANSGCFGIGRPMGTLSVGSRSNTVSAQDGPKRHTHSTCTAHSLRRECDICHAPLMHKTCEAYTLMAQLDDSDLTAAELADPNFETCGMSATIVIVRHRPMSPTPMLRELMRQPCIIAQAFIPLCRWRTCSEARPIRRSVSCSGWILELNDRFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PEX5</accession>
    <name>A0A2X0PEX5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C008g05358</name>
        <name evidence="12" type="ORF">BQ5605_C008G05358</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY80329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PEX5"/>
    <dbReference type="STRING" id="796604.A0A2X0PEX5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03272">
        <property type="entry name" value="ABC_SMC3_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000370">
        <property type="entry name" value="Structural maintenance of chromosomes 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000424">
        <property type="entry name" value="Structural maintenance of chromosomes 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041741">
        <property type="entry name" value="SMC3_ABC_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="11">
        <location>
            <begin position="527"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="411"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="671"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="734"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="862"/>
            <end position="938"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY80329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1215" mass="137719" checksum="366BC7568C5E587C" modified="2018-09-12" version="1">MHIKSLKIQGFKSYRDETIVDPFSSGLNLLVGRNGSGKSNFFAAIRFVLSDAYTSLSREERQTLLHDGSNGGAGGGATMSAFVEVEFDNADGRFPTNKPTLLLRRTIGLKKDEYQLDRKSTSKGEVMSLLESAGFSRSNPYYIVPQGRITHLTNQKDSDRLALLKEVAGTRVYEERRAESMKIMDETNLKKGKIADLLQFISDRLDELKEEKEELAQFQTQDRQRRSLEYAIYQRELQDVAEALEQIEEERRRDVDSANTRREETNEREKAAAELEATLTATRQRLEILRIEHREASDERSDLTKSQAQVECIVRDAEDATHRGEERLHELEQELEQVEGSIHEAETELMEVTPQFEDLSRSEATTRQALETAQTTLGVLHAKEGRRNQFRTQAERDRHLKALVEGHGKAIQEREKGAQALEADLEKAKETLSAIQEGSAEVRKELDGRKEAIREMQTKLAQHKVAQAEAVEKRKDVWKEDAKLDSQLRHAMEQLKTAQRNLSATVDRDTARGIASARAIAERLGLQGYHGALFELFTVEDRYKVAVEVTAGTSLFQIVVDDDDTATQILDVMIKEKSGRITFMPLNRLHPQQMEYPEGNEAVPIIDRLTFDAQYRPAFQQVFGKTLVCKSLEVAGRYARSQGFNSITLDGDKYDRKGSLTGGYHDQRRSRLDAVKNLKEWEGKVDRLSEERDEIKRTITRLDQEVTQLVGQIQVVEGRLARTHEEREPMVMALMAAQADEERQRARIHKLETTLATLRADARNLTQERDAYQAELRTPMVQSLTAQEQAQVAQLNVEVDRLKKELARLSESLADVAGRKNLLEIDLSENLRRRREELRSRIETFGTGGAAKDAQEGTGEDVELRKRELKALGKQIEDLTSKLDDIETETESLNAQVASLEKEREKKEAQHADDQRTIARQQKNVERYLHKRQILMQRKDECNKKIRDLGVLPEEAFVETTVTSEKVNEALKAFSHVNKKAFEQFTSFTKQQADLTSRQEELDESAKSITDLIDTLDARKDQAIDRTFKQVADNFRTVFEKLVPAGKGELIMQRREGLRGDDEMDVDEDEEEAEDGVAVENFVGVTIRVSFNSKTNEGLKIQQLSGGQKALVALAMSEPISTIVFAIQKCDPAPFYLFDEIDANLDADRRTGVAAMIGELSKTGQYICTTFRPEMIPHADAYFGVIFNATKISNVKKLTADQCGEFIEAAEQVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PF15</accession>
    <name>A0A2X0PF15_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C009g05610 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C009g05610</name>
        <name evidence="1" type="ORF">BQ5605_C009G05610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY82982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PF15"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY82982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="103" mass="10981" checksum="5938CD4DF8A189B5" modified="2018-09-12" version="1">MEDERLGTQGLGEDVGKHVASGDVADLDLFLSNPLADVVFRDANVTRSLMVGWVLCVRRRSAYASRRPRADLCGLTLALARGAAASLDLSPFSSLSSPANYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PF33</accession>
    <name>A0A2X0PF33_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C023g09704 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C023g09704</name>
        <name evidence="2" type="ORF">BQ5605_C023G09704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ24103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PF33"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ24103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="54" mass="6013" checksum="7E43D566A00AC3F6" modified="2018-09-12" version="1">MTRHHGCTGTQRQRMQSSGSRCTSARVFEAKLNRLCGNVLGNKQRAGCFGDGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PF82</accession>
    <name>A0A2X0PF82_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mannan endo-1,4-beta-mannosidase</fullName>
            <ecNumber evidence="4">3.2.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C009g05700</name>
        <name evidence="11" type="ORF">BQ5605_C009G05700</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random hydrolysis of (1-&gt;4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.</text>
            <dbReference type="EC" id="3.2.1.78"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.78" evidence="4"/>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY84496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PF82"/>
    <dbReference type="STRING" id="796604.A0A2X0PF82"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045053">
        <property type="entry name" value="MAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451:SF39">
        <property type="entry name" value="MANNAN ENDO-1,4-BETA-MANNOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26410">
        <property type="entry name" value="GH5_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="10">
        <location>
            <begin position="224"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="91"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="94"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF26410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY84496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="591" mass="63813" checksum="F0447B3B1AA9ADB4" modified="2018-09-12" version="1">MASYGAVYDSSAEASAVQSLAEQPYLGVGDEAIPSTPFMGEDSFSNGVPLDDFGSVGMTWEDGNSFDHDSSAGAAEDDSFENRFIRRAFKKRAVSSTSSQAATSATSSPAATTSTNTKSTSTSSSHRQSVTSSSSHSSTPSASKRRSISSQASSTNRTGSSSSRSSTTSRTSTTSRTTKTTTKTTPTTKTANIKAMATNTCASGYAGSHTTISGTGTLPRPTTWVKRSSQQLTLNGKNFRMVGPNIYWLCNDENVGTKGYPTDKGRIREALAIAVAMGANSIRLTTCGVSVGSRYLLEPTRGRFDSSAWDIHDYAIFAAGRYGLRVVLPLVDKLGPMLTNGALYISYAYYHGGKYTFLKWFGSSESNFGASFYTNKHVVDEFRNYVTTVMSRYNPYTKKAYKDDPTIMAWETGNELGGYMGNDGYPPYAWTNSIAGLIKSLSPKSLVIDGTDGIYNSSTKAVAPGAGSKYVDIVTDHAYPRSYALIKSEIPIARKFKKNLLIGEFDWTGNKGGDDLAGYLRNVLSQSTMGLMVWSVFGRDARCCNYVTHNDGYSIYYPNGNSVADQARVLAVSQFVSWSSWGSYRMMRNGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PHG1</accession>
    <name>A0A2X0PHG1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C032g11018 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C032g11018</name>
        <name evidence="8" type="ORF">BQ5605_C032G11018</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000067">
        <property type="protein sequence ID" value="SGZ03752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF463">
        <property type="entry name" value="REVERSE TRANSCRIPTASE TY1_COPIA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="295"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="7">
        <location>
            <begin position="544"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="843"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="899"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1482"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="843"/>
            <end position="875"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGZ03752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2124" mass="233516" checksum="0322C0488030D10D" modified="2018-09-12" version="1">MDSSPASPLAPRDPSSPESSIGEQITTLQAQLAALQASQPAAAAAATPAVTAVPGNAATASKVVFPKHARLDGPKSFTNWLRQLRLALPNQVRGYVLDGVMPPTWTADQLAARDDAAREIIVGSIDSADVSATLDAIPSDDLSAPRIFAALKARFAPDDATRTLELFARLWDFRKMPASVEAYDTWLREYMSIAQEIRDAKTSLNDVLATHVLAMVPSCLDSFRLTFTDEQRNRRDLPELTTLTDRIRIQLRSAGLSTSHSAMLATSSPCPACRAPGHRLRDCTSRAKHPPTGPCRRCHKKGHWALDCKNRGEQARSSDNTQDDTSSSAALQPNVGYFASCLFARRQLPTDAFVVDSGATTHMVADRSLFTTYRQTAHTKIGGIAGGITAIGMGDVAFVAKTGHPITLRGVLHTPGLHVNLLSVARLCDTDRVRLAFTSDGIDIAKDGQAIAHGTRVNDGLYLLDADHTKCQQLAFLSRSESTVPLITLHRCLGHLAPSSIQKMIAAGLLDGFGAGYSDKDVEEFVCNACLGSKGHCLPFPDSESHSPERLGLVHSDVLSFPTPSLTGKRYLVTFLDDHSRKLWAYAIDHKSDVFPIFQTWLAEVELATNARLRILCTDNGGEYRSNAFTEFCKSKGIRRQYSIPYTPQQNGRAERVNLSIVEGVLALLADTRLPATFWDEAAAYFVYCKNRCSHSALAKQTPEFVWNGQRTTATALHPFGCTAWLTVAPDLRSKLDPKAAHVIFTGYDLASKAFRFFDHSINKIVLGRNATFLDNDFPGLPVTTPVDADDTDRQFVVPADTPAPAVKTRTPLVRSAHMDVSSSLDDSAMSAVDVAPGYTGGSLLNSTDTRSSSSPSLSPFSSPATSSARDPSLNDSDDPLDLLSSNTAVRLNLMDVHRSDDDTPETQAPAVDPVGQPSDDDSPDEIDFLSRHHRAFIATDDDDPTLDAIEPVKSITSDPQTWREAMSSDEHNIWAEAAAAEFTAMRDDFKVFTIEPRSSVPPGATIVTSKFVWKTKRNASGEVTGRKARLVAQGNRQRNGIDFSETFAPVARFSSIRCLLALATANGYHVHQADIDKAYLHGELDHDIWMTTPRGFDFPSDKVLRLRRSIYGLKQAGRIWNRHIDTSLRNLGYKATGTDHCIYSRIDDQQRPHYIALYVDDLLIVSPHLDEIERVICGLEQRYGVKRLGPAEYILGIQIRRLDDGSIALSQERYIMDVLARFHFDTTTRGTTVPMTPGLSLTAIPGQGTERIRSWYLQAIGSLLYISLGTRPDIAFAVSYLSRFANNPGRRHWIAVKHVLRYLRATYRDELLYAHGPAKVTGVVGYSDANWGACIDTSISTMGYVFYLAGAAVSWSSKRQTRVADSTTDAEYLALSHAGKEAIYLTQLLSELHVSPIAAAHIFTDNEAAAAVAHDPVRTSGTRHIRLREHFVRDMVNRGDISLSHVGTADMVADVFTKALGPKIFGTHCFALGLRTRHPRLKSTSRSRGGGVRTERGWDLGARSEPGPLAQPRGSLAVDLARAALLFTYREPASAEESPDELDLIGHHSRDESPDEIDFLARHHRAFIATDNDNPEAEAIQPVKSITSDPQTWREAMSSDKREVWAKAATAEFNSMRDDFKVFTIDDRSTVPAGATVVTSKFVWKTKRNALGEITGHKARLVAQGNRQRDGIDFTDTFAPVARFSSIRSLLALAATNGLHVHQADIDKAYLHGNLDHDIWMTAPRGFDLPGDKVLRLRRSIYGLKQAGRIWNRHIDASLCDLGYTATGTDHCVYSRLDDRQHPHYIALYVDDLLMISPDLAEIERVISGLEQRYGVKRLGPAEYILGIQIRRLDDGSVALSQERYIMDVLARFHFDTTTRGTTVPMTPGLSLTAVPGQATERIRSWYLQAIGSLLYISLGTRPDIAFAVSYLARFANNPGHRHWIAVKHILRYLRATYRDELVYTRGQARITGVVGYSDANWGACVDTSISTMGYVFYIAGSAVSWSSKRQSRVADSTTDAEYLALSHAGKEGIYLSQLLEELHVQPVAPAHIFTDNEAAAAVARDPVRVSGTRHIRLREHFVRDMVNRGDISLSHVGTSDMVADIFTKALGPKVFSTHCYALGLRTRHPRLGSASHSRGGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PI26</accession>
    <name>A0A2X0PI26_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C046g12275 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C046g12275</name>
        <name evidence="2" type="ORF">BQ5605_C046G12275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000112">
        <property type="protein sequence ID" value="SGZ30928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PI26"/>
    <dbReference type="STRING" id="796604.A0A2X0PI26"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="852"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="900"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="852"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="922"/>
            <end position="932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ30928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="932" mass="101909" checksum="0C4804B7DB0B792F" modified="2018-09-12" version="1">MLQKSLKSPQKRVPGVCGRAAANQKWLAAHVASAGVARGSRHQTSLPCLAGRLATSLGSAGGISQAGHAPKGGKSLLGICARADYALVVYKQRRKRAVAHFVWVNNHALKNVKSKSCTSKGSWKQLGPKSQALACIKCRNLLLIPTFRKALIRKRVAKKKFKGTAILSGMIEAAVIRSDREAKGSSLRGYRRNQALLNYEHALALASPATYRIHQASIGGSTFRKFRALRATVENLQLGIHMPTILLVAAVYVDGQVGPQSYELVGTEGNPIPYDTSEALQALFGGADPPVAGTKIRVYMVVPNQLGTRARLFAAFVIGDKVDTSASVAQMVDILETIERCKLSDMLASISAEGAATEGVIQREVAAIFERKSSNQQAAWKIPPPSLSSSVFSPVEISSVWIGTTPTAMGRDPKHVGKNLLNSSNSGGRAIIGGTGCVGHQDFLTLIRVEDSSRKTLYNRDVEKRDRQDDNAAHRAFPAATLELAADECNAGNLDQDAVVFLFLCGELHDAIQNRSLQPLERVKMLLTVCYAFEGWSKFVRVFPEYSGDHFLSAATLDSVYKVVNCCIALIRNYRDYWPSEVFLPWRHGTEMVEHFFGSLRKIVPEFDALDFLQAASKISLLMDFSLQVNASQTDSSTGYQHTYDDTTTIDLSALGSYPSDTQIIQASQEAARLARDLLEATKMWPNLVEAGARPPNQFQEDIMVDEVDDPSPAELIDRALDQIRNGATSDRVTLQLEEQAAVESAICALTALDIDVEDMLDSIRTHYDQARQQQAEAEEGNKVQEELNQHYAEFQPAGLHEKAKVDMLPLDGLAQRSQRGAELLLNQLKAHRNAHQCDHLKAILRKGRQSAAISSTASDSNGSDQSPQGSHAAVHSAILRGLLESTNDERWRKLTGMSRNVRWTGGGTAGREMTEHEVETRQNTQDARSHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PLQ6</accession>
    <name>A0A2X0PLQ6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 subunit G</fullName>
            <shortName evidence="7">eIF3g</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 RNA-binding subunit</fullName>
            <shortName evidence="7">eIF-3 RNA-binding subunit</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Translation initiation factor eIF3 p33 subunit homolog</fullName>
            <shortName evidence="7">eIF3 p33 homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C023g09698</name>
        <name evidence="7" type="synonym">TIF35</name>
        <name evidence="13" type="ORF">BQ5605_C023G09698</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the eIF-3 subunit G family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ24077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PLQ6"/>
    <dbReference type="STRING" id="796604.A0A2X0PLQ6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12933">
        <property type="entry name" value="eIF3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12408">
        <property type="entry name" value="RRM_eIF3G_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000657">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03006">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017334">
        <property type="entry name" value="eIF3_g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024675">
        <property type="entry name" value="eIF3g_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034240">
        <property type="entry name" value="eIF3G_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF305">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12353">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="519"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="544"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="583"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="626"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="667"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="695"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="744"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="772"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="262"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="12">
        <location>
            <begin position="578"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="205"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGZ24077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="801" mass="84348" checksum="9CF9CBC0CEAB3417" modified="2018-09-12" version="1">MPALFVPYAAAPAAAPAAAPWNRDHAAAAFPALALYATDHSIALSPSTDNLGPMMSRTLASHGLLAEFPPRTESTDKDGITTVIEYKLNDEGKKVKVRHRIVTRRIKRTLVKSKVNHVVAERMGWAKFGAEKGHKPGPDSATTTVGEAIRIKLSAGGIKTEDTEAEEKTSIQKALAGRKITCRLCQGDHYTTRCPYKDTLGDVLGEGGEEGGVEGAPGGDLGPNPTPSELRAAGGKYVPPSMRAGAKGAGESMNSRNRDDLPTLRITNLSEDCQDQDLWDLFDRFGRINRIYVGKDQETGLCKGFAFVSFESRAEAEAALHKINGLPYDHLILSCSWSEEMEKPFARVNGAVLDAKLGIRFGGFRIDPSLPPVHSISTRATTTTLSMEGIELSRFSSSASTHLPSGAMTLSEMEQPVASLASTTNDVLDTAASPGATLELDGSGSGKKRFEALGSYPDGGLEAWLQVFYCAACMSVCVGEALKDLGPSVSWTGSVQAASEAAFAIPIMRLVGAYGPRKVAIVGAFIASSGPFLASFCSKSFTGLLITEGLIFGIGQSLIFFPAATLPSSYFQKRRNKATGLTYAGGGIGGAGFSLLSSVLLRRWGVAWSLRCLSLVYLTMLKDPRFVCVFFGTSFTLFPLFGPLLLAGFNLSSALGRIGFGLGADRLLGSLNAMILCLAVFGTLTMLLWPVATSLVPLAVFAVVNGAVAGGFFSLTPGVVGSLFGTATLEVTFGMMVSGWAGGYALGAPIAGYILAATGGAGAGYVAFRPAFFYAGALALFACGLICCARVIESKDLKKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PQ57</accession>
    <name>A0A2X0PQ57_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BQ5605_C040g11842 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C040g11842</name>
        <name evidence="12" type="ORF">BQ5605_C040G11842</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Forms a heterodimer with SLX4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the SLX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000118">
        <property type="protein sequence ID" value="SGZ32274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PQ57"/>
    <dbReference type="STRING" id="796604.A0A2X0PQ57"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10455">
        <property type="entry name" value="GIY-YIG_SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03100">
        <property type="entry name" value="Endonuc_su_Slx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027520">
        <property type="entry name" value="Slx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048749">
        <property type="entry name" value="SLX1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050381">
        <property type="entry name" value="SLX1_endonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208:SF10">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21202">
        <property type="entry name" value="SLX1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016094944" evidence="10">
        <location>
            <begin position="49"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="GIY-YIG" evidence="11">
        <location>
            <begin position="23"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="121"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="417"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="417"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="446"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="481"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="515"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="548"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGZ32274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="586" mass="65676" checksum="B24EC052824B07D4" modified="2018-09-12" version="1">MHSQPLQPSSLKQPNLPPPPPPKPPPLPLLLLLLLLLLLLIELRPSLKQPNRTYIGSTPDPKRRLKQHNGLVKGGAFKTKRFRPWTMSLLVHGFPSKLQALQFEWAWQNPHLSRHLHEQNFSIPSSSSSSSSSSSSSASSSVKVIVDQEQVEQVPSPKLKKKKKKKERNRSTSTSNDFTEPILTNPIPQFPKTILSNRGLTKVQVLMFMLTSRPWKAFDLSVVCFEEISKSWWERALGLGVVVRTEAGMKRFEKGREGVESSSPWGEQRGRFLEGVKVMDWFEGVQGQNDGGEKFRTDDGEMIDAHWAKWIERVGSASSNDCAICHRPVNIEDHLEFLLCTSEKPNSTSKMVTSNTNTCNALYHLSCLAHHFTGSVEKEDQPPLLPEKGRCPSCLADLHWGELVRGSYRRLDEELGKREKMKRAEERRRKKEERERERLVLEGGKKGRKKKMGRGKGKVEVEQSGSEGGAEERIEFVSASESEEEGDEDEEDEVERSLAISVEADGELERGSDESASEEEGEELLVEVKKGRGKGKGKGKGKEGPTKKVAKVKVTKAKVAKEPSASTPKKRGRPKKVVEAYVELSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LP44</accession>
    <name>A0A2X0LP44_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C011g06456 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C011g06456</name>
        <name evidence="2" type="ORF">BQ5605_C011G06456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LP44"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY12286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="78" mass="8721" checksum="479371726C5042A3" modified="2018-09-12" version="1">MNRLDFEEQEFQGDLWCASDEDEPTSPAQTAEEMPSSDDDIEDSSDNELHSNWSASSPVGQLRDDMILEALDAQKGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LPF1</accession>
    <name>A0A2X0LPF1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C011g06553 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C011g06553</name>
        <name evidence="2" type="ORF">BQ5605_C011G06553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LPF1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF470">
        <property type="entry name" value="CYSTEINE-RICH RLK (RECEPTOR-LIKE PROTEIN KINASE) 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="27"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="106"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY12599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="488" mass="54449" checksum="C64ABB44D183E938" modified="2018-09-12" version="1">MAPRAGWLEAVGTFSPPLFHLSPGTPIIRSKWVLAIKRNSEGCIEKYKARLVACANMQKDGRNYKETFSPTGRAASRRLLLGLAVENKWETHQFDVSSAYLNGEMAGREWYKVFAGWIKSVGFVQTESDHAVFVKTEGACKLFLLIHIDDSLLTGDGNLDGFIQQLKSQFEAKSLDKATFFLGQRIMRDGKMGVAIVHQPHFISSILKDHDMVGCSPRPTPIMLYKSHSCKDLTFDASTKPYRVIVGKLLFLSGTTRPDIVFAVSKVALHCNNFSQNNWEALMHILCYLQGTQDVGLLFRKSEGSPLLNGFVNADHGADPETRCSVTGFVILCAGGAVSWMSKRQALVTVSSTKDEYVAMSFATRKGILLCRLLSELGFPQTEPTRLHGDNQLAIWLAKHPAFHARTKHIGIHFHFIQDHIAEGTIEMVWIPPNMMAADVLTKGLGSRKHWDFVHAMGLVDALREGASWKERQEVEEVCVAYARVNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LQ18</accession>
    <name>A0A2X0LQ18_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C010g05893 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C010g05893</name>
        <name evidence="3" type="ORF">BQ5605_C010G05893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LQ18"/>
    <dbReference type="STRING" id="796604.A0A2X0LQ18"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070042">
        <property type="term" value="F:rRNA (uridine-N3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019446">
        <property type="entry name" value="BMT5-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF26">
        <property type="entry name" value="FERREDOXIN-FOLD ANTICODON-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10354">
        <property type="entry name" value="BMT5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="25S rRNA (uridine-N(3))-methyltransferase BMT5-like" evidence="2">
        <location>
            <begin position="134"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY13561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="458" mass="51147" checksum="4D50911035E57760" modified="2018-09-12" version="1">MGSGKKNKRGGAPKAKGRLAAALSTAQQAAALKARQAQAEANKEELLNNKKNKETNKQAKKKRRIERLLNEVAEEKRKGKERATELQQLLDEEEMSSDEEGSKAEGTKEIVVKTVAPPRKRRGTVPYKLGERILLVGEGNFSFAHALLLAQPPIVTPQLLYATAYDSQQAAQEKYPDLMEHVNAIRKAGATVLFGVDATKLQACKELKEHKGAWDRVVFNFPHVGQGITDQDRNVRANQTLVLGFFRSVAPLLRVGTSSIAAASTKKAQTNKKGKRTRRDDSEDEAQPIGHGDDDFDSDMEVDSAELANPALRPLPPPPTTSGTVLVTLRTVSPYSLWSVQHLGTRGSLLAPSILPKPLPKTPQPDYLLVRSFEFDPNDWQGYEHRRTVGFKEGVSSEKNDDLQLTARERGEKRRWEKEQQERREKEERDANAEIRKGGKALMRTWEFELKDVDGLYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LRF9</accession>
    <name>A0A2X0LRF9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BQ5605_C013g07312 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C013g07312</name>
        <name evidence="11" type="ORF">BQ5605_C013G07312</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LRF9"/>
    <dbReference type="STRING" id="796604.A0A2X0LRF9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF692">
        <property type="entry name" value="TRANSMEMBRANE AMINO ACID TRANSPORTER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="553"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="593"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="629"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="774"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="802"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="879"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="414"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="71"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="185"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="746"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="217"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="304"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="746"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY15276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="907" mass="97218" checksum="F3D4DB84CCB2110E" modified="2018-09-12" version="1">MFERLFGISMVESLRNYPVGKQASRLGLAVIVKSRGAGGRGWARVGAAIGCGIVAVDVLICAVSVPACASSVPAGPNARSSLAPPDPRLSSLQPSTKTPLGPEDNQYHLRNCHLQPLSSSITPFSPPTTTSRRIPIARPAAGPSAGGGQGGGNQPAGGGTAWASSLDLVFSFSRSAAFFGENLPSGPSFVDSQRYRHPTHARQSVDDADSSVTGGPSDRERDHSEDRDESIATSDDDWSVDDEIDRDLVQSWDGDRLPSRKEQLPSNAVVSPSGKRRTKSTTARLSSNEGSPVPNDRLPYVPPSSLGSSRLGLDSGMSSVAADRDRVVDERSPLIAPTLRNSSTSATFSPANQPSPTRGDRLSPLLAPIYTEPVGKPQLQQQRRTSGKNNAAARRLSLISSEAWSAAIEEQRGESTWGQTLFNTVNVLIGVGLLAEPLAFADAGWAIGTILLLFCALITNYTGKMLAKIMRQDSSLATYADVLIKAYGTRAKNMVYALFILELGALSIALCTLFADSMESLYPAVSSQAYKVIFFFIILPTTFLPLRFLSLTSLLGIISSFTLLLVLVTDGALKKHQPGSLRDPMPTAAGPRWMRLPLSFGLLMSGFAGHAVIPSLYRDMKNPSQFNSVIDIAYIIAFSISMLFGTLGYIMFGNNVSSEVTRDLLATKGNPAVLNKIAVWMVAIHPLLQLNPVVKYAVANAPLVQTFEVMLGIQKTRPMNERRSRPRFRSPHDSGASAILEGSAIMSEDSSSSISGLEGNESSSRTKNQEPFLLRYRAFITRPLLTALIVVLAIVIPDFGRVLSFLGSASAFIICCIGPIGAYLILGRQTPFNKGSTTPNTITPSAMEENVFSSSVSKSRLGGDEASKYPLVVKGFERVLCWSLLIVSACLAITGTVWSVMPLERSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LRQ1</accession>
    <name>A0A2X0LRQ1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">adenine phosphoribosyltransferase</fullName>
            <ecNumber evidence="6">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C013g07315</name>
        <name evidence="12" type="ORF">BQ5605_C013G07315</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="6"/>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LRQ1"/>
    <dbReference type="STRING" id="796604.A0A2X0LRQ1"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002055">
        <property type="term" value="F:adenine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000021">
        <property type="entry name" value="Adenine phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050054">
        <property type="entry name" value="UPRTase/APRTase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002636">
        <property type="entry name" value="PRK02304.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315:SF3">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="11">
        <location>
            <begin position="61"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY15288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="184" mass="19806" checksum="BF6205462D4A0E76" modified="2018-09-12" version="1">MSSPASDVELIKNKLGVHPDFPKAGIVFLDIFPLFQDAIVFETLITHFMSHIFTHTLPRTPHNKIDVVVGLDARGFLFGPILASRLGASFVPVRKSGKLPGKTIETIYEKEYGQDKFEMQAGAIKEGQTVLCVDDLIATGGSAKAAGELITKSGGKTVEYLFVIDIQIGGADVLDAPSYSIVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LSD8</accession>
    <name>A0A2X0LSD8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C012g06945 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C012g06945</name>
        <name evidence="5" type="ORF">BQ5605_C012G06945</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LSD8"/>
    <dbReference type="STRING" id="796604.A0A2X0LSD8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23161">
        <property type="entry name" value="Prefoldin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000003">
        <property type="entry name" value="Prefoldin subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="72"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY16673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="141" mass="15630" checksum="10F0275B036B872A" modified="2018-09-12" version="1">MASLEAQYQAGTAEYSKLQADYSKAVAHRQRLDAQQSESQAVQKEFATLTPDNSVYKLVGPVLLKQDPTEAKANVEKRLQFINSEIERVEGNLKELDANLDKKKMDLVHIQTQLKQKQETQQQLLTGGGAEVKSKSSAVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LSN0</accession>
    <name>A0A2X0LSN0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C012g06898 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C012g06898</name>
        <name evidence="2" type="ORF">BQ5605_C012G06898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LSN0"/>
    <dbReference type="STRING" id="796604.A0A2X0LSN0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="637"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="764"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="489"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="706"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="767"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="785"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY16537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="794" mass="84409" checksum="2C1046ED50A3A372" modified="2018-09-12" version="1">MRPTEMSGCIDPTPPPTPPGLLFPLSPLLPRTPSSTRRTTGADSPSSPSPTRSQRILPIPTRRLGPTLLPMSPSPLMPALSLSPPDGPINSSSSTIGGGVLFEPDSVRRRWNSSLEERGRAVANSLPSLDPRWERAVSPLTLHTPESPPRLGQARSLHESPRKDSAVALSAGASSCHESVSVTATAGLPTLGFLTLDPHKSDLYKSSADPRAAGPSAHDPASTSDTEPNYWRAPVSAPLERRSLWCCIVPPPPPLARADSYPPYVPSSFLATGSSPLPPPTSVQHFFEPSLPVASPPLEPTLSSSPLSSSTSLSQPPSISLHHQESQSNMTEQSSTTPQKIIVSLPSSTASRGASSASRGQTDSASSTKGPEVSQHDGQSQHRTPPSFSIRGSASSTRGRIARQGPVTRSASGSKPSMPSTPVAAATAATDSVAKSPSTAPMLSAGIYTSRWATDDTETAATQSPATPSRASTRGGRGRGRGRRGRGGPITSSTSTGTPPRSGAVTPKEENQLRVSQSEADQLPRNETPAVGVTTWTGSESTPQTNRHASSRNVDQTSTTSTTTTDEASLSLSKLAIAEDKDDVKTSPGNKEFLAKGSPAPRRVYPTRDRVSTGGVAKPRMTTEELEAKMVRMRIENEKTQAQHDKLEAERAEAEEQRKAAKALREEQRKAEVAKQERSKKLQSDIDATRARSAAMKMAAIQGRAWDQEKHNRDDNDMSAAPSYPSEELGPLVKDHLGRMITAPTGAVIHHIGVKDDNAVWDRVEHYEDDSEEDEEEARAVAAQLTGNKSTAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LVA2</accession>
    <name>A0A2X0LVA2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C013g07390 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C013g07390</name>
        <name evidence="3" type="ORF">BQ5605_C013G07390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LVA2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY15515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="705" mass="78874" checksum="9A319BF0DA0C52C6" modified="2018-09-12" version="1">MSEGAREKRLGSAEGATNISHKPSRHDTTARYIINGFLTRPVRLTCGLGQGDPASSSVWDVVFQPFLDALHRRGIALNLSLPTIHPYPQSRAITSLAFADDVVVAVAGSESLTLLDDLALDWRLATNGRLNTDKTVVLPIGCRWEAGDRPLVVKAEGESLEWIGLSFDPTGNTELANVNLVARLEAVLDSARDRGLTHHTRAFYVNRYAIPKILHILSADIPPLEVVKELDRILVDFVRGGKRRSCYGKDVVFTPRFKGGLGVMRMQDVVDSVAARVWDVLLGGSDAIWQGLARAAIVRTHPAPDFDLATDAWPCDYTPIRTDLHPRWQAVLKVPSTHNAQVKPRTLTLANLLALPIKLHTLHYLPGAPAVSRSPYDADYAAFANYAKVADLFRRELYPGGGFHLWTPPTDVVVSNSEYDQRGRPQREHIVAWYRHAINRLRFTPIAQPVAAVRINGPPRVRPRSEVRPTTPLESILPHPIDPPQRLPRPALPDQSTQYNLLSMDRPYTIRRVRRVLNAKAFTDTIGFRDSLQPDDLKGFWKGVNSKALTAREREVWFKLVRNFTPTRSLQFHQKHDDSPACLVCGAPKDDREHYFFDCVDSGNVWIAARSVLCDALGLDTIDNTHYTAVQRMFGLPKLKASLRDQEGAGRTIVIFTGLVLEMISSGRWGMQKWGTRMEGVVRRRIILEERLKLRAGGAWGRRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LVN4</accession>
    <name>A0A2X0LVN4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C013g07139 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C013g07139</name>
        <name evidence="1" type="ORF">BQ5605_C013G07139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY14870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LVN4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY14870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="52" mass="5750" checksum="9389D5B1BFA6D8F7" modified="2018-09-12" version="1">MSGQESSDEFSVPQSVERGVEVEVIVDGLGCGWTVYKGIDDGGFERYRFGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LVP9</accession>
    <name>A0A2X0LVP9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C016g08285 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C016g08285</name>
        <name evidence="5" type="ORF">BQ5605_C016G08285</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY21868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LVP9"/>
    <dbReference type="STRING" id="796604.A0A2X0LVP9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF4">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="78"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY21868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="488" mass="53096" checksum="234B072B25181AD8" modified="2018-09-12" version="1">MSTFAKQSFDAIGYALSRPWPHLTSQADGTDTQTKPCFLIRSAYPLKVYQHILSIASIPSSSTTSTSTSGKDSSSVLVDLGCGPGLSTFAFVPHFDRVLGLDPSKNMVHHATEILKGKDASTQDKLRFAQGKGEDLSQAVLGLEDRSVDLVVAGQAAHWFDAQAVYSQLTRVLKPGGSFVFFGYGEMFFPQPSAPELNQLVPEYSGNLLKDYWQQPGRGIAESLLSQYAFPSRDSDKKWDTSSFRRDYFLRASSDSSPAVPTNPEDPPHVQVEKHDLILERVWSLEELEAYLRTWSSAHTYDEKHGPGSDVVKSFVEKLTTTGYGKGRADGKERIGWGMGMISGRLVYFLRVLLLFSHASSLACSVRFKKSCFSKYPPFLLWFKSSCRPSSLVTNCPQSSLDFSSVLSLAGFEESEAARAPRPPDLGRRGAEDVAGFVVAAGSVVAEVVVAELESAVLSESAPNRESSFDVVLVDVPSGLEGGAVDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LW35</accession>
    <name>A0A2X0LW35_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein ERB1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Eukaryotic ribosome biogenesis protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C019g08880</name>
        <name evidence="6" type="synonym">ERB1</name>
        <name evidence="10" type="ORF">BQ5605_C019G08880</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat BOP1/ERB1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY22998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LW35"/>
    <dbReference type="STRING" id="796604.A0A2X0LW35"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000576">
        <property type="entry name" value="Ribosome biogenesis protein ERB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03027">
        <property type="entry name" value="BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028598">
        <property type="entry name" value="BOP1/Erb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012953">
        <property type="entry name" value="BOP1_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1 BLOCK OF PROLIFERATION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08145">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01035">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BOP1 N-terminal" evidence="9">
        <location>
            <begin position="550"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="833"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="260"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="928"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="307"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="326"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="389"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="479"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="944"/>
            <end position="953"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY22998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1188" mass="132583" checksum="BF26EE87D7FADE1D" modified="2018-09-12" version="1">MKRISLRLRLSANECTSCPPNASECDTSGRATKCSYGILTNGECIKKFCQRSTNIRGDECCTDGMAETCSDANTTLTCRKGWKLLKPSNDTVLVALDGFANGTLVDADRCQGPYAAHFGELPYILNFLGSKQQFVAPKDAPWNWKIGNQLSVEECALATLFPSSQNNDRVFLYERKNGYFNCRAFHRQEIKLEFKGSGGRYDFGTGGTCAEARVSWPFAAEYFDRVGCEDILVRETRQWDGSVRQVGVGWRSLDHSQAAPLPFAASQDPRGESRQSSLGRARTRRPLPPYSAGVERVHHRTMAPPRRSSSLGSKPNSQRLPATNFAAPSSSTRSASQRASTSTPNAPTTSTAAASSSKKRRNSSFSGSGGAKLDVADSLGLDGEALDFGSDEEGDDEDEFTGIADDEDEEDDDGDFPELDLEESEEDEDGDEDEQELDSDEEAILAELRAEDEDEGSSSQNTDDEDGSDFDALMKKYTSKPDEADRAAFETTWDEDELPVDYMKRSRTVKSRITGQDKTEWDDEIEADYASDSSTEETTNRIGNVPAYFYDEMPHIGYDIDGKKVMRPAQGDELDKFLEGVEDADGGWTTVKDKLHQQNVALTEEELDLIHRLAKGENPDSSYDPYADQIPYFSSQVMATPLTRRPEPKSRFLPSKWEHKKVMKIVRAIRSGRIVPRRPGAPSTSANKDDPAKRFYGLWSQTDAEAAPHPMHMPAPKMALPSHEESYNPPEEYLWTEEEKEEFLSKEKEDRRGQIIPVKHAALRQVGAYGNFVQERFDRCLDLYLAPRMLRRKPRLDIQDPSELIPKLPSPQELRPFPTTASVEYRHPNGVRIRSVSIDPTGMWVVTGAEDGEVRLWECAIGRCAMKWQCGDGGPIYDVEWCPDPERSIFAVASAHKVHLISPLPLLGEEVASRTKTYALAGFNAASTGEDGEKKKHVQPQEVRWSKPKGDSERDEGRLVVVDVPGTLKQVTWHKKGDYFATVAAPCEFGLLDSVVSGARSVLIHQLTKHQTQAPFTKMKGDVQCVSFHPSRPHFFVATQRHVRMYDLMKQALAKTLNPGVKWISSIDVHPQGDNVIVGSYDRRLVWHDLDLSSTPYKTLRYHARALRQVHFSRAYPLFLSTSDDGSIHVFHSTVYSDLLTNPLIVPLKVLNGHEPKESLGVLDAVWHPREPWIVSVGADGGAKLWCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LW42</accession>
    <name>A0A2X0LW42_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C013g07339 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C013g07339</name>
        <name evidence="3" type="ORF">BQ5605_C013G07339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0LW42"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1256"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="650"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1835"/>
            <end position="1860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY15345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2079" mass="230930" checksum="7F6ACEF68A8F8EA5" modified="2018-09-12" version="1">MQTGDPGSAPGARAPPPPASAPTSLPIAGTKETQATQVAGRTATYAAATNSSVVSNETPAQQQDRLARLQALPGILAAIQAVPGNRADRFVQAIFATPDFPSTVATALKFSALNATRNIINPFANALEVSLSHKSTGRASATDKGELVACVRTLLSPNTPICFDTGVPLSGDLEAFMPRITGLQHSSTFRTGVLHHRITVGFVSAEARDAALASAPMLVWNSANARFAKAHPFHRNMLEMRINVGVVRPPSKEQIVAAFQSIVQQLSTKGHSCQLVQVLRVIHVDTAKAYAHTVGDFSAFIHFDDASLFQHPTTTLKEILPSRMDLPTRGLDVTAVRHDYEKEAPCARCHFAGHVERCPLMQAANRKEAEDLARHAVMRGAGMVGGGEQTGVGRAATTTTNNIRPTANNNNTSEVVAPSRALGTDQLESRNRFAGLEVEGGQEDDIEEEVAGKEGEEKEQVKEGDEDTGAKADDEDSDSDGNAGAGIDKAGGDGKDDDKDDDEDDDKDEQDDSSEGSERRGDDVMKDGAEEEDEGMETEVEEEVEQEQGVQDDSIMIIDDGQTTITTVSRESTPRSPSWPPLSPETLAKSLREGAEWDRANAEAAARVQAENEAIINAQLDAQEPLVRHQFAEWGQEDGQLRFINIRGTGSRSNKKMKRSQTVADLSDPSDDPVDVKRVLNRVKGRAGKEVAGQGKRVTRSMSAAAAMQVEGAKAKAEKGQHYRQEHVYIVYPIMIKHLITNWNVRRCMGIPEKRRDIYTYLSTFKASAILLQEHFIKPELWQCIKDEYEGKAFISKHCLTLIPADSPLIDAEILRTHSALDGRILVTSFRLRGDIRILEINNLYAPVDTKQRLTFFDKLHFHRTQSTHLRLLGGDLNDCPLPAIDRRNQGRHGHHWPILIGKLDSPYTDCIRFKHPLTPSFTRPNIVRKRPKSFSRLDYFLLQRTHQKRLVQASTIYDHPKDLSDHRPVSIVLVLSDERGDAAQPNNSLPTTSNQLHRINAATFKTAAFQGMLEGWLEGASGEEPVGELEVVLGNCEKEGRELARREHRERVERMAVLVGRVQDLEALPVMGDEETAEWTRTTEELRRAVNERARQLRIRAHVPEIATEERLSRPVHAKLAARSSDSKITALRLPNGELTHDIDVALDHTQAHFQRLYNLEPRDRDHVERLRDDFLAPIRAARTCDDPSSDPLFLRRLSEAHIELLQQPITEDEVVAAIATTHPGRSPGPSGVPYELYHTAPRAWAKALSRAFNAMTERGSLSPKQGQGLVRLLFKHHKIGADRAELSSYRPITLRECDYKLFTKVYVARLNHVLPDLLPPQQHGFVKGRRSADASFHLRLLIEELGARGTEFPDAALLSLDQSSAYDLVEHEWIFAIFDALGAPAAFQRVLRMLYSGDSTTARYIINGFLTPPVRLTCGLGQGDPASSSVWDVVFQPFLDALHRRGIALNLSLPTIHPYPQSRAMTSLAFADDVVVAVADSESLTLLDDLALDWRLATNGRLNTDKTVVLPIGCRWEAGDRPLVVKAEGESLEWIGLSFDPTGNTELANVNLVARLEAVLDSARDRGLTHHTRAFYVNRYAIPKILHILSADIPPLEVVKELDRILVDFVRGGKRRSCYGKDVVFTPRFKGGLGVMRMQDVVDSVAARVWDVLLGGSDAIWQGLARAAIVRAHPAPDFDLATDAWPCDYTPIRTDLHPRWQAVLKVPSTHNAQVKPRTLTLANLLALPIKLHTLHYLPGAPAVSRPPYDADYAAFAIYAKVADLFRRELYPGGGFHLWTPPTDVVVSNSEYDQRGRPQREHIVAWYRHAINRLRFTPIAQPVAAVRINGPPRVRPRSEVRPTTPLESILPHPIDPPQRLPRPALPDQSTQYNLLSMDRPYTIRRVRRVLNAKAFTDTIGFRDSLQPDDIKGFWKGVNSKALTAREREVWFKLVRNFTPTRSLQFHQKHDDSPACLVCGAPKDDREHYFFDCVDSGNVWIAARGVLCDALGLDTIDNTHYTAVQRMFGLPKLKASLRDQEGAGRTIEIFTGLVLEMISSGRWGMQKWGTRMEGVVRRRIILEERLKLRAGGAWGRRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LWN2</accession>
    <name>A0A2X0LWN2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C012g06822 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C012g06822</name>
        <name evidence="10" type="ORF">BQ5605_C012G06822</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LWN2"/>
    <dbReference type="STRING" id="796604.A0A2X0LWN2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="240"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="535"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="574"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY16252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="657" mass="73149" checksum="3C7630FDB601FEF6" modified="2018-09-12" version="1">MTYFIGTAWHRILPKAEQGRIWAVLNPGPFNIKEHVCITVMASTGSSGALAISTFAVEKLYYNITPSYGIAISTLIEKPLCPTRAASQFFGYGLGGLYRSILVYPTFAVWPSLIPSVSLLETLHREKDLRSQRRRYKFFWIVFACIFVWEWFPEIIAPTVTGISIFCPPTHRGSLVDRTNPDFTRIFGGTNANEGLGLFSIGFDWLQITSGAPALSFEVPSARVAITEAVRFSLLPATLYLPWATMVSQGIGVVLCFTIVVWGYFTNVWNAKSLSFMGQSLFHENGSVYNASLILDSKFDLNKTALGEQVLYFGLNLSIGASFMHVFVWYRKDLVEAWRQWRSKIHNDPHYLKMQAFYLATAIGAFVIALATLYAGHSGMPWYALLIGVLFALVELPVLSIMTAVTGFHSSGSTLCQMLGSALVPGNARASLYFGGSLMVKDLKLGQYTKVPPRALFAVQAVGTLLGSVLNLVVNDFTPQMNSIVSSQREVLLDVEGTNLWSGYVVQSYNTQAIAVSENSWGALGKEMYGPHNKYFIIPLGIRLLVPLPFYIGHHFWPNLCLNQIVTPEMCRCLGYLSVGINSSVFVSFLLAIYAQFYLRRKRSTFFRKYNYLMAAALDGGTDFMIFISTFTINGGAGKQYLFPNWALNPKGHYDCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LXI5</accession>
    <name>A0A2X0LXI5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01003 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01003</name>
        <name evidence="2" type="ORF">BQ5605_C002G01003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY29038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LXI5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY29038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="373" mass="41226" checksum="3DA32B809691BD42" modified="2018-09-12" version="1">MNMTIAELLAFDVAPADASLHIELSKDEHTQYSTLSSTRCPVLLKGRPMELSDTSRGEAGLEISNTEQGRSAVHSRVLKGLVQSMGPSRFEDIAGTARSFRWTGDGQVARALTTNEIQKNAYIEDGRIQEKLPERDKQYGALAQRYPHFGSLDGGAVTTTTTSEIGSLVCFGLKRGMHSISCDQTAYGEEVLFIGIVTTNHCNQDTLASLVLLSNVVVQELRLIKKTCYSTHLIDGTMPFRMINGRQVIESLGPSTTTYRSTTDLTSCYPDERLISTSAHAEQRFAAFGACPACEMPPAEPLQAAQMPPRKQGSQLQQKGSLTTKQRASQQSKEGLFEAWSHAQHQPKRRAPRATFDRPPRARKRSERVFEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LXW1</accession>
    <name>A0A2X0LXW1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C014g07563 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C014g07563</name>
        <name evidence="2" type="ORF">BQ5605_C014G07563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY19109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LXW1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY19109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="198" mass="21237" checksum="141F28726BD2B9F7" modified="2018-09-12" version="1">MASICTGRGYVLRVVKTFAQNNFDLLASFAGFSSVLVSQTWSPVTENGCRFDALNSIDGCRRGGPLTGLGVCTDMAHHEGRCDVESRLRLSLGSPRTAGERSIGRDSVSLTTPWTAYDAERAFSAGRRTINQLQHATSGPFLKAKTCVGSWAGAVAENDAAPIVRLSYSAQPSKVVPAKRRATGTSRETIHLDDDDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZ21</accession>
    <name>A0A2X0LZ21_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01556 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01556</name>
        <name evidence="2" type="ORF">BQ5605_C002G01556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY33825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LZ21"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY33825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="215" mass="23428" checksum="C7C59FA12211F77A" modified="2018-09-12" version="1">MSCEEGGSHQFSMPKKRSCCFQTVKLCCCPCWAFMSCAMSNGKSALTLLSCTFAEVVSNARGAAFTSSLGMHGGNEDGPEMTCLKCGLTRSEAGALQMMKDAEKRGLRSRRVFSSPHKGPGYFSNHGLIIPTTTITTQHSRGEPEFSYPTTSYPPPSALNRSPERLRTDRLDLPSHDHASSLGTPVTPQRSQEGNPAVAWVARQQAYQVQQHHSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M0P8</accession>
    <name>A0A2X0M0P8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C018g08698 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C018g08698</name>
        <name evidence="2" type="ORF">BQ5605_C018G08698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY26087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M0P8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY26087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="334" mass="35289" checksum="CDF6986FA445DA56" modified="2018-09-12" version="1">MPPKAKAPPLPPLPLTPKQEQALQGLSITEKTLVVQAVYETGTAEFKAASKLLQGHPLLVHRPKHFFSAEKMATVHAALSKQLGLAPEQPQPQHSAQLLQVARKWYLERVYELRGVMQQHVDRFKDAYKELEALKAGEMDWKLTDPERLAEVQATSNAVVQAAPAAVPSTTPPPTSTPAASETQPTVVSDAVPSLPTIFNSESMKVQSEQDRRVKKRKVSVEPEPTTAPPAAGTGLGVPSTPLTILPSIPTTEVTSTPVATTTTTSIIPQDAVPVINTEIPKSISKEDTTDAMNVDIDPLAALTSIDLDIEAGVAAAVAAALGGEVVVGANGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M0X4</accession>
    <name>A0A2X0M0X4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C003g02135 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C003g02135</name>
        <name evidence="8" type="ORF">BQ5605_C003G02135</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M0X4"/>
    <dbReference type="STRING" id="796604.A0A2X0M0X4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030705">
        <property type="term" value="P:cytoskeleton-dependent intracellular transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22211">
        <property type="entry name" value="HkD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008636">
        <property type="entry name" value="Hook_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043936">
        <property type="entry name" value="HOOK_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947:SF28">
        <property type="entry name" value="GIRDIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947">
        <property type="entry name" value="HOOK PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05622">
        <property type="entry name" value="HOOK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19047">
        <property type="entry name" value="HOOK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116907">
        <property type="entry name" value="Hook domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HOOK N-terminal" evidence="7">
        <location>
            <begin position="132"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Hook C-terminal" evidence="6">
        <location>
            <begin position="346"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="526"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="886"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="342"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="564"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="643"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="834"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="540"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="890"/>
            <end position="914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY39059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="914" mass="103822" checksum="82186B7B3B4796D7" modified="2018-09-12" version="1">MSFLQAPSPQLGPSIVIWINSLASTLPSSNRTDADDVDGAGERGGAGAGRRVVRSLNDLNDGVVLGEIVGEVESAWCTDHLQELNHYDMDNMRRISSMRLPLQTGLPARSYRLTFESSTRSALTFSPPSFSDPAYFRPLATTTKQKTLSENWVLRFNNLKRLYKLLIRYYEDVLRSPTVSLPTPNLQLIAKSDPTSDVETCRLAGLVLALAVCSEKRQFYVEKIQSLDEWVQRELMISIEQVMSRIKTRTPPLPSSEMLNDRDVIVDEDHDDGDSEFYALHQDRSRLLSDKDALQIVYEELLRAHRTLQEDHEEALSAVAAAEVRANEAVAVVEANKGERADAGYKAELDRMRQALQQTEDQLSEAEQIVERQSRIVEELQTRVEDLEPKAAEATKLKDQMDEYRHAVEKAKKAENVIEKYKKKLEDSADLRKSLRMLEEQNSDLLDRYGTLEEEHAKLAAFKPLMDSYKNKIDTLEGKSSTLTKENDKLRLEIQRATEKLKIAQEQQNMDREALGLYEERVHELEAGPTPRKAPRGDVVAEDDDEDSNEVGGELDDAFRGTTMTDLKLQVRKLKRQLNEAMMNSAEHSRVVVLENLLEDANRTKAKYEMDYLRGHREKLGVEAKLEEIISGKSRLGDGPEAAIALRMRLNETVEELERLRHDRAKLDVEYAKLKDEHTVAKSDLILVNRDQLDILRSLRASVATEKEALTAEVERLKTSLRGAEDKVKMQMSQVNTLLMDKVSMQNDGISQREQMLEQEKESSHLRTSLMSKNMSEEDRARVGALQAENDKAAAEVKDLKEKLFKAKAFIKNQDKLLRERHAAAINGMGEEAEQALRSQIAQLKEDLERQKNNTAEVEARYRREQQLMLSAWHELGMRTMREGVANAGHTKSQPASWMGQQRLRSNGNGLRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M3C8</accession>
    <name>A0A2X0M3C8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C002g01772 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C002g01772</name>
        <name evidence="3" type="ORF">BQ5605_C002G01772</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY35504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M3C8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY35504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="153" mass="16659" checksum="9ED702F198FAAFDE" modified="2018-09-12" version="1">MASTSKTTLFTRPSHLLAPRPQHLPLAPPHSQRLFSTHSLSRSLRLSPRSRTRLQNISFLAATLVSIITVSLAMSGSAGVDLPCPARQGTKVGMQDEKGKDWATSTGAGRTTGKRRWLEEPVVIAQSSAPRGKEAQHRTGPRTGLQQEEESRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M4H1</accession>
    <name>A0A2X0M4H1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">BQ5605_C003g02003 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">BQ5605_C003g02003</name>
        <name evidence="18" type="ORF">BQ5605_C003G02003</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY38341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M4H1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0229">DNA integration</keyword>
    <keyword evidence="14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016093992" evidence="16">
        <location>
            <begin position="23"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="17">
        <location>
            <begin position="298"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="559"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="SGY38341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="604" mass="65738" checksum="63F0E2AD554585B2" modified="2018-09-12" version="1">MAPLWFLSCSSNFLVWSPLVLRSETYHRLSRCVTSNFLVWSPLVLRSETYHRLSRRDNITPASYVPLWDHYACSSICASVDSQTVLPGLSPYLDEPLAAPKVWQALRERYGTVSAVNLLPVIQRLFSSDPVPVTPDLFLQFRDSFENDTRLLQDLQVTVNALLASHLLARIPSSFDAWRTTFVAAQGDSTEMPSATEIFTRLYRDVKARPVDTPVAAVATPQARHGCSRPCPNPSCRKMHWLRECPDTAWAAAHRARRTAEKKASQPVASPTAVDTLNSVSFTACLLATPLPFRKSAWLLDSGANRHMTNNRGLFSELCTVAGPRVGGVAGSLPSTGCGTICIQTSKGPITVSNVLLVPDLPCNLLSVFQLDQLGYRVSFASCCASIARPSGAVVATAQAIGNNLYALALGPTPCTPKALLTIPANVSLLTLHRRLAHLPVAQIKNIVQSGLVTGVDWVYKDQELRDFYCNACLASKAHALPFARSKSIASGRLDLLHVDVARMPRPTFGGHRYMLVIIDDFSRKHWCILLALNMRQSPLMSGEVGCRTEVVRGKLRNRKGARTGIGPAAGELARAPRQLRASKSPPQGGGLAGARPSPLAPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M4W3</accession>
    <name>A0A2X0M4W3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g02334 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g02334</name>
        <name evidence="2" type="ORF">BQ5605_C003G02334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY40179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M4W3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY40179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="52" mass="5695" checksum="B36AF871C2A432A7" modified="2018-09-12" version="1">MMAKPARVPQFHDYVMHLAKPEPARTRLTSQSLSRAGTDGSSSYCGSLELNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M6M4</accession>
    <name>A0A2X0M6M4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C001g00087 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C001g00087</name>
        <name evidence="1" type="ORF">BQ5605_C001G00087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY43940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M6M4"/>
    <dbReference type="STRING" id="796604.A0A2X0M6M4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY43940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="362" mass="39328" checksum="F020879FA7302368" modified="2018-09-12" version="1">MTHPTASGSILRAVLLPTSAPDSPSPSEPLTITLNDALPSSLNPTSVGLQSWGSSILLARMIALNPTSFGIARGEMNRLDVVGEEVIATDYHEAVLENLRRWVTGMIRAFENCLTSFSSIPRLRNIASNTAAICPSSSPLNSPLVRPSDSHPGSPLLAPTPNLLSNVPVVTAYKLDWSAVHSSLLFSSTTNSPLHLPPPFDRPFHTLLAADVIYGPEHALWLKSCVQQFLIQPNQYTPKPRKRRVVQTPTPFSLDSVKDALVGVELDSVRTTVPTPTTSDAQSSFTSVPSPAFHLIVPLRSHHANAITSIATVFPLASSLPPRTSPDDPYRVAIKRMTELHRVKGIGRADEESYRLYEIGWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M6R3</accession>
    <name>A0A2X0M6R3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C007g04367 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C007g04367</name>
        <name evidence="8" type="ORF">BQ5605_C007G04367</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY59971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M6R3"/>
    <dbReference type="STRING" id="796604.A0A2X0M6R3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF3">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY59971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="470" mass="50077" checksum="59409601BAEB1E66" modified="2018-09-12" version="1">MQSIRNKFSNSTTGVSPGFSSGVMKKRGQVCVSFAMMFMLGFNIAATGANVPSISASFHVAYSVISLFFLSYVTGFITTCIASSYVAREFGVRATLAGANILWIFGCLIFLLQTSFGACVLALTCLGLGSGLFEPTIVTVVTQQSTPVVLFFLYSSFAIGAGISPLIIGGFAERSIPWTNFYYFPVTICLVLAGLCHIVFQGYEETLSHDQAPSAHGMATFSSTYPGDSTTKFGRRASFGSSVMSAPSRFAGLEIDRNCVAWGHKSDVSAMDRVGRVLRLRVAWIGFFLVNLSLATGELLGGWGTTYFLVLKEAPPGDSRFIQSGWWFGMALGRLVLPILSPRVLGERLFAIVLLAFASCMITVIGAVHSYKSDAVALAFYGFAYGPIVPHILSMVSSRVSTDLTGTVISLTLGVGVLGGAAAPILFGAIAADHGMLSMLPTCLIAGTLLGIFGWLLVPDHDDELKSTFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M952</accession>
    <name>A0A2X0M952_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C004g02883 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C004g02883</name>
        <name evidence="2" type="ORF">BQ5605_C004G02883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY68394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M952"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY68394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="209" mass="23083" checksum="ED8A3989CAD11BB5" modified="2018-09-12" version="1">MRDDDPSPIPCFLSTGILYKSSSSQDLQYQGSLQQPHTQGKLNNSNAVTSASSSSSSEGLDYYGSDSNSPRSSSFSSTHSFQSAPLSPSESISSSPNLALRRFAQRQADLLHEQRPNLHVVVVALPPSDRALQLDGTRDCNGERTIDGELVTYEKIFYASAFTEDVVFGVYLFEQGRLTLDKMHDVYAFASLSWEKFGPYIFFDPMSPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M9W8</accession>
    <name>A0A2X0M9W8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C004g03123 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C004g03123</name>
        <name evidence="1" type="ORF">BQ5605_C004G03123</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY70224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M9W8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY70224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="71" mass="7700" checksum="2D575B3863D91DF0" modified="2018-09-12" version="1">MSLPSQGGSGDLDSSHCAFEPEEDLQNDLLYDIFVQIVAGIMRDSPPHYNCQSKVSITTTMIIASSSLHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MA78</accession>
    <name>A0A2X0MA78_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C007g04526 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C007g04526</name>
        <name evidence="1" type="ORF">BQ5605_C007G04526</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY61103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MA78"/>
    <dbReference type="STRING" id="796604.A0A2X0MA78"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY61103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="152" mass="16450" checksum="463BC538C9DDF35E" modified="2018-09-12" version="1">MVPTTKTKPTSSSTPISSQNHFGSLLFCSRCGDLLALPGDDDEIVCDACGQVEDAAAYENQTITTRSHSAAFPSSLRQKKTSLVKHTGDVEKKKVYLLELTPCFHLASPNRSMKCAKNVATNACRSRRCNSGPPMKEPRFSTLASDVGIKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MAB6</accession>
    <name>A0A2X0MAB6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C011g06555 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C011g06555</name>
        <name evidence="4" type="ORF">BQ5605_C011G06555</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635:SF196">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="178"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="659"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY12609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1332" mass="148031" checksum="A39DC4A883070DB2" modified="2018-09-12" version="1">MTSLGSTSLLNGKINFQRNRMEQDLAAQTEDLSNRAQPDSLSKNARPEFSFNFPCKTATPPAPHPASNQGIAYSLVEKSSESPSSETTSPSPSPPPATPKSIITRSKLIAALSKPATREAPPTAPALEASEPSPEPSSPTPLPSAAPKARPDDADTDDEADEEAEDQEAPPKDSINEDRKRASLFSNLRSHNAEVFLLSETGRPSPERVAQWTQECQDLKLSALFTPFNNTAILWKSDSVVITFDPESPPNTLRASFSFPDRVTDATFCVGDSKVRVVSIYAPSSDKPDKKRFLSHLSTALRQVVRDEPSPPALLVGGDWNCVESQPLDSENQNGTNYGGQEMRDLATANNLFDAYRLHHPKGRATTNHSAPGTCRRLDRIYVSPDWVDLFHDHKIWAVVLKSTHSMVVARFQVPGAIDIGPGKFKLGLHVIKGDATCEYLTSIVRTLYNKALLQTPNDPPAAWTSTKHRLLPELQALARTFARFRRGGSEQERADHSRYGAALRSRLDPSLAGPSSIFIRLRKVRASDLIPSLTVNDVVHSDPDSMLGAASDYFERVYEDRPIDDAALKAIIDGLASTRLSPADSLKLEEAYPLEEMTKAQAACKSNSSPGPDGLPVEFYRATWPATGPILRDVINSIPTKACQPGPLPRNTAHIHLIHKRGERDQLSNKRPILLINADKRIISQAHNQRLAPLLESLIGPTQRGFVPNRWIGMNIAEVQCLMDPGLPGSTPGSGMLAVMYLEKAYDRLSHPYLDAVLCAVGLGPKARQWYRATFTNQSASIFLNGWLSATFDILSGVQQGDPLAPSLFVLAIEGFACQIRLRVKGIDIAGLQNVRELLFADDACCALHNLSDLDHLNRAIELYERASASKLSNVKSFLYPLGAFRDRSIAPDLGTWRLSDSQFRYLGIQVGVEIAEDAGWEDVKASTIARIRSIPMYDLPYAAKCSIINIYCYTKILYYSRFLPAPKSVVKEIEEAAMLAIHGRASDGTQRRPKVSRSRLCTPLDHGGFGLIDLPRRLAIDHAKWVFQLRAPDGCFTCHLFDIRIRLQAPNEPTPFTLSRPAPNQHRCPWIWIWWAYFCHSPPKWDHAVRKTTKLLPARWVRYFEAWALVTTLNPPELSKSQNLEQWATHVLYFPAGHGIQLSVNPTLFRGPDGEVMTPSSFVNASKRHQVFIFPPIFPKGHQKVFDLPEQRWNAWWKALRKVRRVHSDAEDTGHLLSLGSLHPGSQVASPTSPHPNNRSTSCVMCLSEAPECLVHLAVSCPFARRLWSALSPTPHPVFVDFVCPVVSRSERRLVELRVLFFHSIWKLCRRRRFSSDLLEPITGTEFEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MC12</accession>
    <name>A0A2X0MC12_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C008g04983 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C008g04983</name>
        <name evidence="1" type="ORF">BQ5605_C008G04983</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY78887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MC12"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY78887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="224" mass="25290" checksum="AEED64ACD0C7958D" modified="2018-09-12" version="1">MRGKKAVVVSKKTWEDGTSYEQLKYPLCEVEYIFIKCMRNVRWSELIFTSSFRERIKLLVYDEAILIAEWGLTARDEKTESALWRIPPRDPTHFAPSMLKLYNNVSELVIKLSSLLRPTDLFHLRNIVVEMTPHTKTAMTNVLTTAVMSLLSDLPILPPHRSLQAQYVYSGPLLRNSPVSALDDHGSPEGAFSPGAPRGRILQEESACERAIPTSAPLVVRSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MDU0</accession>
    <name>A0A2X0MDU0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C009g05757 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C009g05757</name>
        <name evidence="4" type="ORF">BQ5605_C009G05757</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY85452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MDU0"/>
    <dbReference type="STRING" id="796604.A0A2X0MDU0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="3">
        <location>
            <begin position="72"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="163"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY85452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="178" mass="19069" checksum="CD705169926EF3A3" modified="2018-09-12" version="1">MLPIAASSKVTLEHLAATCSLRSRTFSTTRIGSLAATGHQCTTRATHEPKTNPSPTKHSPPQSQSQSNKTHYLITLHRSPANLPENVAQTCEALGLPRRLSSSIVPITQVSSGQVLAIKELVGVRAITLDQVLSSQWTQRKGAGNQGSGLRSNGNPRGVIRVGSERARGDERGYKIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MEB9</accession>
    <name>A0A2X0MEB9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C015g07752 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C015g07752</name>
        <name evidence="10" type="ORF">BQ5605_C015G07752</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic initiation factor 4G family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MEB9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000020">
        <property type="entry name" value="Eukaryotic translation initiation factor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.970.30">
        <property type="entry name" value="eIF4G, eIF4E-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022745">
        <property type="entry name" value="eIF4G1_eIF4E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036211">
        <property type="entry name" value="eIF4G_eIF4E-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253:SF9">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12152">
        <property type="entry name" value="eIF_4G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101489">
        <property type="entry name" value="Eukaryotic initiation factor 4f subunit eIF4g, eIF4e-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="MIF4G" evidence="9">
        <location>
            <begin position="990"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="154"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="199"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="392"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="520"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="656"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="715"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="881"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1112"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1275"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1368"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="335"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="362"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="419"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="520"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="665"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="715"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="881"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="925"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1113"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1275"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1299"/>
            <end position="1308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY17334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1603" mass="166421" checksum="17EE288B8D4D74F3" modified="2018-09-12" version="1">MSRTPSAAPSLSTALGSTASGPSVASDKKPYGIKASAYAVSDIPAFRAPIAGINYAQAASKSKPSPPTLQGKDVPVSGTFGGASPLIPAATAMANAAATGTSAAVSSAPAGGHMRNQSVKVDAINVPASRVNAIRTGAADAIAFGNVNDRNAVLSSSPAAPPPASNGNPKTFGTVPAGSSPAAAAKAPINLHSFFTGSGAAASPAPSGNDRRPSLGYDASRPPQISSPSTTSQHLSQLSSASASFAPRQQAPPFIPGQQQPHSARLSQGSFPSPSLQFAHLPASSSFVQPGYGPKSPAMQSANVGQYSPGPSGGASAQRNGSFTGASIVAGRPNGSGNRSFGNAGPTSPRMQSSSLPSQQAPYGQQPSWQQPPYGQQQYGYYGMQFTPQNVYAPSQQVGPNVSSSLAPNGSSTPANIRSPAPAATATPGLAPSPSPSHSHSTTPTTPHYSAYSSPQPPAALPSHHPSFHPTHASASGTPLRALSSAAHAPEFKPNADAAVWTPRKSAAIQIRDPKKEAAAVAAAATAPKATEAPGAKADKSEASASATRSLPAPKPAKNVTTSVEEIAKNEVKISPTAEDRLETKLKVAEDASVKDKPKTEPASVIAKPEVAVAVLTAKIDEKKDESVTEVETKSAIAADGKDVMPKAEALARVAEAKSGDAKKNNAAAAVSTASSPAPASRLAPVRDERASASQDLGGALAKARFAEQVQLGDATPASGAPAPSAKGAVDAVDESPAAGASTAALSEARKIDDLASVSYPEDIHSPKAELNANAESGRYRYDREFLLQFMNVCTEKPEALPNLEAIGMMDAGAEAGSSRGNFGAGNRRAAMPPPAVPGRGAGPAGGFGTRSASVGGVGAGFGSMGSFGQAPLGTSEARFAQSSMRAASGASGGGRAGNMSRTTSQSGLSGGAFVPAAPSQTGRIRSERGKRREEPGRAGGDRGHGGGGKHTAGDGFENATLAPRSETGWVPTVIGGAPTLDANSPELVQRKVKALLNKLTLERFESISNQILEWADKSVTETDGRILRQVIALIFEKATDEANWSEMYARLCRKLMETVSMSIKDESVKSADGSFVVGGALFRKYLLNRCQEDYESGWKLKETAAAAAAGKAADDNAKKDLNEQAEKEAKEKGESEPSKEAELLSEEYYAAAKAKRRGLGLVRFIGELYRLQMLTERIMHECIKKLLANTDNPDEEDVESLCRLLTTVGKHLDNAKAKQHMDIYFQRMHTIANNPKTPSRMRFMILDVADLRSNHWQPRHDSAGPKLISEIHSDAQRAAEESRRVASSGGKGLPRLNDQLSRPNSRRGQGRDGIGAPAADGWSQPVPQRPAKAGDLSAFGKTRENVAPFTFGPTGAFAAKANKAKEAARPATPSNPFALLSGGGSDSAAEASASQRPKLNLAPRTKPLEGELSAQADGTQSEDLAVDGDEHAEEKDEDEDDGAIDPNAISMSRAEAERRSGNSVKEFFSVKNIAEGTASVEALPSEYRGILIAAFADAAVDKKADDVNITRQLFSDLSTKNTVRHQVMLDSLQTLVTGLIDLSVDVPNIYTFAASLLMGAQATREEVETMAQSMISEEDDDEEELERGRQQLYAAFEKASGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MEN2</accession>
    <name>A0A2X0MEN2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C015g07872 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C015g07872</name>
        <name evidence="1" type="ORF">BQ5605_C015G07872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MEN2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY17734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="48" mass="5662" checksum="20688E297405C881" modified="2018-09-12" version="1">MLWKVFYKQEITMPDVRVGRWKVEERDDARVSAYSLEGEGERTSVSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MEY0</accession>
    <name>A0A2X0MEY0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C008g04912 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C008g04912</name>
        <name evidence="2" type="ORF">BQ5605_C008G04912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY78679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MEY0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY78679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="52" mass="5405" checksum="74A363691F2AB017" modified="2018-09-12" version="1">MVEFHARSDSSRSTASTSSDTAAALPSHSVLFPPSHLVPSSVLGDYQPTCTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MG24</accession>
    <name>A0A2X0MG24_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C005g03640 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">BQ5605_C007g04886 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">BQ5605_C008g05020 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">BQ5605_C019g08841 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C008g05020</name>
        <name evidence="7" type="synonym">BQ5605_C005g03640</name>
        <name evidence="6" type="synonym">BQ5605_C007g04886</name>
        <name evidence="5" type="synonym">BQ5605_C019g08841</name>
        <name evidence="7" type="ORF">BQ5605_C005G03640</name>
        <name evidence="6" type="ORF">BQ5605_C007G04886</name>
        <name evidence="8" type="ORF">BQ5605_C008G05020</name>
        <name evidence="5" type="ORF">BQ5605_C019G08841</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY22681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY64232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="508"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="755"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="778"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY22681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY64232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY77447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY79043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1423" mass="154797" checksum="FF01C2D3D46E3560" modified="2018-09-12" version="1">MPPKSAPGATPQPGTSLEAAIAPIVARPPQQPASFAATELLRDSAGYQDWLLVVRSRLPAGVLRYLESGEPCTSWPPSLVPLWDHYALSSLCSSVDPRLVLPGLSTFLDDSDGAPKIWQALRSRYGATSAVDLLPAVVTLFSTEELPATTDSFLQFRDGFENQLRLLTSSKVTVDSLVASHLLSRLPPSLESWRSTFVNDQGDSTTLPSVSAIFDRLLRDIRARPVDAPTAALARSSARDTRAPRTPCPNPKCRKMHWLRDCPDTAWAASFRARRAIENSNKPAGERKPSQPAASPAAAPSVADEHLSPAIYSACFLSASSPFDKGAWLLDSGANRHMANDVRLFTHLQPVKGPHVAGVAGSLPSTGSGSVALDTTSGRIAVADVLHVPSLPCNLLSVRRLDRLGFTVSFGSNVATIRNAAGTAVATARAIANDLYTLDLTPAPCRPHALLASPSHVSLLTLHNRLAHLPVLLLKKIVQKGMVTGVAWDYSDEECRTFHCNACLASKAHALPFARSTSIASQRLGLIHVDLAQMPHVSFGGHRYMLVIVDDHTRKHWCILLARKSDTFPRLRDWILEVERATGDSVKTIRSDNGGEFTLRSFVDFCCSKGIRRELTIPYTPQQNGRVERPNRTIKEGILALAYSAGVDSRLWGEAAMYFVRCKNMTPHAGINGDIPDARWYGYAPDISSLRTFGCRAWHCLPSPSRSALDPKAIPLIFVGLDDHSKAYRLFHPTTRKVLLSRNVLFRESEFPASTPTPALFSPANPLPDVVASRPDQADPPQPLLPAPPRSPVPRAEQLIPAPDASDQGSPALARNVPDQALPAPFASDQGGAPDQGSPDSAFSTPCPSPRLRPSSYDFSALCLAPEFSDDVDDALHSPAPVCYLADAAAALLDTSTVDPAELVAPARDPPHWRAAMASPQADEWRLAARDEFDSLSRDFSAFTPIDQSLVPADAKIIGSRFVFRTKRDQFGKVKSYKGRLVARGDSQRSGIDFDETFAPVAKFTSIRALLALSAARGYHVHQADIDKAYLHGKLDKPLYMRVPEGIALPGQVLQLHRSLYGLRQAGRIWNDEIDSTLLGLGYIATESDHCVYVKTVGDVHHYIALYVDDLLMIGPSLPEIERTLQGLERCYGVKRLGEAEYVLGIQIRRSSDGSITLSQEQYLKDILARFGMSNAHPVATPMISDLHLEIETNPTPFADRTRYLQAVGSLMYASTGTRPDLAYAVGYLARFSRSPSEAAWGAIKHVFRYLAGTLSHGLCYSHGDSAPVIGYSDCNWGACVLSSKSTMGYAFLYAGGAISWSSRLQSRVADSTCDAEYLALSHAGKEAVFLRQLFGELGLPSSAPTLVLGDNQGANALTRNPVFHARTRHIRLREHFVRDMVALGDVAVQYINTADMTADIFTKALARDLFARHRGRLGICSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MG81</accession>
    <name>A0A2X0MG81_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C008g05352 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C008g05352</name>
        <name evidence="2" type="ORF">BQ5605_C008G05352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY80300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MG81"/>
    <dbReference type="STRING" id="796604.A0A2X0MG81"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF10">
        <property type="entry name" value="OS12G0136300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="718"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="940"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1078"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="960"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1041"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1078"/>
            <end position="1103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY80300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1129" mass="117978" checksum="B660B24501686063" modified="2018-09-12" version="1">MASSSRRPPSSSDTHPTTINQLRFRKSRSRPMKTLSSLPPEIVRQIVGEVDLIVAQERSGLGMLSSMGLFPADVSLDDVIDAGPGELERTAADATAAGIGSPLFRLGWADHSCFVRRDVKCLPPAAFFGMLAGFLGTGAGDNPLGANGAAPGAGPNAATAAPATTTNATTTPTTAATTASASASTATTNPARSNAPAASTSTIPSTPRQANANATASNRTGTTASAAPSTSASTSTSRTSANPSSSTARAPAGSRSGSQPSTNTNRGTANADDITITRAYSLSRDSLSGEWETDEENEPCTCPSCFFERMLAFPGFENEGINLDDPTSMMGPTRGYDDDADPSDQPIVSEDDYDSEFDNDQDDDDDEFDEDEYDDDEEYDDDDNDGSDSDVTDSDPRYYGPPRPYSNGLPLDPLVPLLFVNRTFLHASRAKLYCKITITGAWHGSLLLRSLQAPEHAARTAVEDFDELPKNYLATYVRHIHFNAKGDVSLARGGGQIIVDILKLCTRLQSLTIAPTFLAHARRPLLKALRGLNELKQVSLSSSNDPDVPMLFTTPRISHLMNTAWRELEELTVHGLRPSLDGTIDEEHCMWTELGQNFGMEDAKEHAAVSMACRAANLATNVEALREKLGRHLPEGPKPRGLTALKLTHPLAPATEWSHILQYSSDTLKILDIVHPFASVTPQGLASTLLTFGVNLTHLSIDVESTWIADTRDSSLLTRDEPRRTSGKGPPPRPKDYVNGRPTAQVVNGIAKYPFLLDAIVPYLRNLKNLSWTGRLASPPMFLSFPPSLSVVAWSQCSSIQPGRLTRILKKRVTRSRNDADGLQGLSAQVAPGLTCISVTDDDVDWDADETDLLDAELKERNVCLHLSSMGPTMARGRGVGAGAGAGGANGAFGFGFGVGIGGNANRNGGGAAGAAPPAAANAAPGGAAVAAAVPQPLAGAGGAAGATTDAGARRVRPRTNAPTTTPTTTTTATATAATTANGTGAGAGTATVTGTGTATNTSGFPPRQPPQNPALGNFTPVSGVGTTGTGLRVAPVSMPRNVNGNRAPNSTTTATRFPPDFFRFNPHLPAATAAGLGSTTSTALGTTSTSTVSTSATSTSTAPIFGASASTSTPGQPTDRAPMFRFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MGB6</accession>
    <name>A0A2X0MGB6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C008g05392 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C008g05392</name>
        <name evidence="4" type="ORF">BQ5605_C008G05392</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY80457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MGB6"/>
    <dbReference type="STRING" id="796604.A0A2X0MGB6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055561">
        <property type="entry name" value="DUF7137"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42028">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42028:SF1">
        <property type="entry name" value="YALI0E30657P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23585">
        <property type="entry name" value="DUF7137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015969738" evidence="2">
        <location>
            <begin position="18"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7137" evidence="3">
        <location>
            <begin position="114"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY80457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="289" mass="30219" checksum="30ABC26F7C18784E" modified="2018-09-12" version="1">MRTATLLFYYLLGGVAAHKVPSGEVVGAVDTQLIYDRGDVQRHDVALPPPLLVKGTSTSASSSPTITPHVLGFHKRQAQPNATTTAVMNTTTTAVMNTTTTTTTTTSSVSIPATAAAGGLSYLQPAATDAVSYYKVASGQLITFAWTYTSLYVTPTSLTFEARCTANSFTYPVGPTTGIPASQTSLVWDPYAYAQSAGAIPFAQASYTLRVYDERGINAAATGGYFNGAQSVVYFALYSPAAYTPLASGWTCVACSAAMITKHLSHPLVMALPVTIALVLIGGAGVLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MGY1</accession>
    <name>A0A2X0MGY1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C008g05330 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C008g05330</name>
        <name evidence="1" type="ORF">BQ5605_C008G05330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY80220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MGY1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY80220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="89" mass="10198" checksum="92E9B7123EC62E87" modified="2018-09-12" version="1">MTVWALEVFRIVPRFSNFSMRFSNFGVRFYNLGGRFGNFGVKFSNSLPRLPMVQDQGSDCARFASFTKGGRPVEKNCTPETSLMQWTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHG4</accession>
    <name>A0A2X0MHG4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C016g08267 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C016g08267</name>
        <name evidence="4" type="ORF">BQ5605_C016G08267</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY21719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHG4"/>
    <dbReference type="STRING" id="796604.A0A2X0MHG4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056136">
        <property type="entry name" value="DUF7719"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37846:SF1">
        <property type="entry name" value="DEACETYLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37846">
        <property type="entry name" value="YALI0B21296P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24841">
        <property type="entry name" value="DUF7719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7719" evidence="3">
        <location>
            <begin position="243"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY21719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="317" mass="34652" checksum="34BF5D6924F7761E" modified="2018-09-12" version="1">MATTRSRKTWTPTPSPSPTRSSASETERAPPAQTRSTTTASSASSTSEPILTKRIRPSQVKPPPGLEPLIRLSPEDLAGIVEWKDEDGEQLEDNVDESDADAERSHDRGITVRHFQSKLDDDLEEGSEPPALWEHLVDALLWTIPFTFLFVGMQKGRCIRSDADKTVTSSIFRDYAVHAQYGQDLPRSLIVSHLSSLLPTPPSLAAMYILNLISPTTITANHSTPSTTSAPTSFPTLPPRIQQPLLLLLCTATGIHLVHLTSTQSYLQAMASAPAFGTLWVWSVVKMDLGWAVAGLLLVGVGVGARGELARVKWWWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHJ6</accession>
    <name>A0A2X0MHJ6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C008g05351 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C008g05351</name>
        <name evidence="8" type="ORF">BQ5605_C008G05351</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY80296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHJ6"/>
    <dbReference type="STRING" id="796604.A0A2X0MHJ6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="95"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="46"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="186"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="46"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="209"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY80296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="736" mass="81262" checksum="B844EBB501075E41" modified="2018-09-12" version="1">MRLLTSTCKRRLRSPPSIATYHPTHSRLDHPVGVDILPIRRHCRSMPASPSVSRSSRSGSPAASVTASASAGAAGQPYHANHRDRKLPIRRSAKACVACRRAKARCDGPELWPCRRCRESCHECIFDGVPREELGTRLVTAATSSDQDIGAAPIWSTERRLLQVEQELAVLQRTIQEHAALLVKATSTSAPDHSNGQAQQQLSHAGPSRRTEFDHKGKERERGNPIHQQQHHQADANRVSFEPGFPSFPSASNALPASIISAGAGGSGHVAAELSIDDPMLDRLSRSAFDTFWTHMAPWAPYIDPTIDTYDAVRARSPLLLYCILSIATRFHSNAAWSHQCEQQALKYMRATVYSDIPPTLDDLKGTLLYNAWLSRGAPPGHSCTLASQLDLPRSLERLLSMMDKPDANRAFEQLMPTVRTWLSLYAQDLWLSIATGRRGLVTIDFSVTSARSLLKFEALRPVDARIIAQSELVTILGGVQENFVKTQQTSIAETVNIIQRADKHFDAWMDTWSAWAELQEQSTWKYMIASFKMQCEVGRFYINTLGLRDITSPEEVQPIQMPVIKSAIKAAFEVQLVAQKYGSRRMGYSTEFTLISCCSAALFLLKMIKLMPDEFKRDPEGDVKDVATTLGAIKLTSKLLAEAPRQNYHLAVASALSHLESQYLSPSFVMDSMPNPMMPTGFSGNSSSSGSTPGGQNAVLFDPELELAISSVIEESNFWSWSQAQPADSFSGLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIQ7</accession>
    <name>A0A2X0MIQ7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C036g11494 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C036g11494</name>
        <name evidence="1" type="ORF">BQ5605_C036G11494</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000063">
        <property type="protein sequence ID" value="SGY95443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIQ7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY95443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="245" mass="27524" checksum="A956A3A1F6BB4878" modified="2018-09-12" version="1">MYGEQFEDLLERGFGLGRVGGIKIQPILRRKCMTLIPTIADFAQHVSGLRVKSSDKHRWQQSVVATALKDRLDSKATELSRKNETRWNSIHLCLQNHVLFSSAIDYYMARDDTPSNILLDIGEYLKTLTVQFQDATPRTWDVIAEFERVEGMLDNKAQTASPMVRIAAKSALIVLGNYYSKKKLQKVYLPLYEDTPEAGPPSPIQIPMLAPTTICMVMKEVTHKALTTTTSQMPSSSTGLWDASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJ08</accession>
    <name>A0A2X0MJ08_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Glutamate synthase [NADH]</fullName>
            <ecNumber evidence="19">1.4.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="primary">BQ5605_C035g11385</name>
        <name evidence="27" type="ORF">BQ5605_C035G11385</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="21">Forms L-glutamate from L-glutamine and 2-oxoglutarate. Represents an alternative pathway to L-glutamate dehydrogenase for the biosynthesis of L-glutamate. Participates with glutamine synthetase in ammonia assimilation processes. The enzyme is specific for NADH, L-glutamine and 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>2 L-glutamate + NAD(+) = L-glutamine + 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="1.4.1.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="24">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="24">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-glutamate biosynthesis via GLT pathway; L-glutamate from 2-oxoglutarate and L-glutamine (NAD(+) route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Energy metabolism; nitrogen metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.14" evidence="19"/>
    <dbReference type="EMBL" id="FQNC01000064">
        <property type="protein sequence ID" value="SGY97131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MJ08"/>
    <dbReference type="UniPathway" id="UPA00045"/>
    <dbReference type="UniPathway" id="UPA00634">
        <property type="reaction ID" value="UER00690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016040">
        <property type="term" value="F:glutamate synthase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019676">
        <property type="term" value="P:ammonia assimilation cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097054">
        <property type="term" value="P:L-glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00982">
        <property type="entry name" value="gltB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00713">
        <property type="entry name" value="GltS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000006">
        <property type="entry name" value="Glutamate synthase (NADPH/NADH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000031">
        <property type="entry name" value="Glutamate synthase 1 [NADH]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000017">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000022">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.60:FF:000001">
        <property type="entry name" value="Glutamate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000001">
        <property type="entry name" value="Glutamate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="entry name" value="Glutamate synthase, alpha subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006982">
        <property type="entry name" value="Glu_synth_centr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012220">
        <property type="entry name" value="Glu_synth_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006005">
        <property type="entry name" value="Glut_synth_ssu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051394">
        <property type="entry name" value="Glutamate_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01317">
        <property type="entry name" value="GOGAT_sm_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008730">
        <property type="entry name" value="PRK11750.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43100">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43100:SF1">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00310">
        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04898">
        <property type="entry name" value="Glu_syn_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000187">
        <property type="entry name" value="GOGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="Alpha subunit of glutamate synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18 24" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0288">FMN</keyword>
    <keyword evidence="17" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="13" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="15" id="KW-0408">Iron</keyword>
    <keyword evidence="16 24" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="26">
        <location>
            <begin position="71"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="981"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="23">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1197"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1202"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00024383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00057049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00068518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR000187-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR000187-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="SGY97131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2126" mass="232278" checksum="3B339F907A4C381A" modified="2018-09-12" version="1">MAPTVLAAPVNNKKAVSFDLPADHASSSSVNTESSSLDLLPHADGVLRDETSLCLPAAQGLYNPENEKDSCGVGFVCHIKGQPSHKIVSDAKALLCNMTHRGATGADSRDGDGAGVMVGIPHNFFVREAERELGVTLPREGEYAVGNVFFKKGNDELLASQKATFEQIAESVNLRVLGWRPVPTDGSILGPAALSREPLILQPFVVLSTSYGYGSTPDPDSTFDEKYFERQLYVLRKHATHTLLLSSGFYICSLSQKNVVYKGQLAPVQVYNYYHDLNHALFASHFCLVHSRFSTNTYPSWDRAQPMRWVAHNGEINTVRGNKNWMRAREGNLQSSRFADELDLLYPIIETGGSDSAAFDNVLELLTVNAVLTLPEAVMMLVPEAWQNNTDMEKEKVAFYQWAACLMEPWDGPALFAFSDGRYCGANLDRNGLRPCRWITTSDDLMICGSEVGTIYVEPEKITRKGRLQPGKMLLVDTVEGRIVDDKELKMKTAAKQPFATWIDSQMLSLPNIIARERAKGASLTGVLDDSTVSTDPRLLAFGYSFEQLDLLLRPLVNDGKEALGSMGNDAPLACMATAPRVIFDYFRQLFAQVTNPPIDPIRESIVMSLECYVGAEGNMLEMNPNQCHRLLLPSPVLTTEEANALKRLDTVNPEWPARTIDITFDKAEGPAGYEACLDRICAEVSNAIAENIRVIVLSDRAVGPDRVAISSAVATGGVHHHLVRNKQRSKVALIVETGEAREVHHICVLVGYGADGICPYLAYEAMLKLRREGLLKKDLTEGQVIKNYLYATNNGILKVMSKMGISTLQSYKGAQIFEALGLAEEVVDRCFVGTASRVAGSTFELLAMDALDIHERGYPLRETVLPPGLPETGEYHWRDGGEPHINDPAGIAELQNAVRQKNQSSYDAYAANARRQVRAVTLRGLLDFDFVKATPIPIEQVEPWHEIVRRFATGAMSYGSISMEAHSALAIAMNRIGGKSNTGEGGEDAERSDLLPNGDTMRSSIKQIASGRFGVTSNYLADADELQIKMAQGAKPGEGGELPGHKVSKSIARTRHSTPGVGLISPPPHHDIYSIEDLKQLIYDLKCSNPRSRISVKLVSEVGVGVVASGVAKAKADHILISGHDGGTGASRWTGIKYAGLPWELGLAETHQTLVLNDLRGRVTIQTDGQIRTGRDVAIACLLGAEEWGFATTPLCHLNTCPVGIATQDEQLRKKFTGQPEHVVNFLYYVAEEMRSFMAKLGFRTINEMVGRSDMLRVDDSLRNPKTANLDLSALLKPAWQMRPGVATFKSRAQDHKLYIRLDNKFIDEAEPALLKGLPVRIDCDVVNTDRALGTTLSNHVSKRYGEEGLPKDTIHIYAKGSAGQSLGAFLAPGITIELEGDSNDYVGKGLSGGRLIVYPPKVSPFKAEENVIVGNTCLYGATSGQAYFRGIAAERFAVRNSGATAVVEGCGDHGCEYMTGGRVVILGMTGRNFAAGMSGGIAYVFDGAKDFRAKVNMEMVELDTVNDPREIAELRGMIEDHQHWTGSFFAERVLKNFNQWLPRFVRVMPLDYKAVLEAEAAKQAKEKAAKHPPVDIVIPVAGVQPAHKSNEPSVVDLEDAMVDDTTAKKRVEQLDKIRGFMKYKRLTESYRNPRKRVQDWAELSTRLGEDDCKQQAARCMDCGVPFCQSDSGCPISNLIPKWNDLVFKGQWKDALDRLLMTNNFPEFTGRICPAPCEGACVLGINEQPVGIKSIECAIIDKGFEMGWMKPQPPKVRTGKSVAIIGSGAAGLAAADQLNKAGHSVTVYERQDRCGGLLTYGIPNMKLDKRVVQRRLDLMAEEGVKFVTKAHVGVTHNIDEIRSANDSLIVATGATWPRDLKLPNRNLDGIDFAMTFLSANTKSLLDSNLEDGNYLSAKGKNVIVIGGGDTGNDCIGTSVRHGALSVTNFELLPQPPPTRDQASNPWPQFPRTFKVDYGHTEVSSLFGSDPRQFSISTKEFVSDGNGKVKGINTVRVAWEKDAFGAWKMAEIPGSEEFFPADLVLLALGFLGPEEAAIKALGLEQDARSNIKADYGKFATNVPGVFAAGDARRGQSLIVWAIAEGRRCAAQVDEYLVGNTRLPAAGSIPERSFKSRKPAAPVAIQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJ40</accession>
    <name>A0A2X0MJ40_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C029g10633 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C029g10633</name>
        <name evidence="1" type="ORF">BQ5605_C029G10633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ14984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJ40"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ14984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="520" mass="58358" checksum="1E6020C4945812F0" modified="2018-09-12" version="1">MLQQATSKGQLLRTCASPGAGAGADILIDLWHFFDRIYARLAKLGMTWEEAVRSPVWNKKLWRRVRRWIPPPGILEPLVREVFEKLGRCERCLEAIRKSQVSDPVGIELYTDLGPCGGPDGKADDGVRLYSCQRDTNSLEGGIHRNLRQRFPKSGVSPCHVNACTADYVLVHNLTVSPTPPSQFEEAATILTHYPLYSQVGTFNRTGKPFVGHYDLWLTVELHCLRRKTSAYFPRHSITVSDIVNSLLYTPSTETFGIVPVVQSPTAQMRFLIEPYQVERGTLRLEPVKWSPRNLLQNNTPAIQHMQSRLPTDRKLRHDWLAERQGTRFDVLYVHTPSERALYRYISSKVRLGAPQNLRILEITELWNKYANGVDIFYKHINTWASRWSSLANAQATMNLGGNDVRVIQALLTDPSRGRDVSMLAPQPLLGHKPPVVGRLTEVEVEASDPPTSSIRPFVATASSNAGSSAHLGTRGYHNSGKALSICGQTTCRRKGSKLSNDGLTRWIRTTHNHEGSVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJ56</accession>
    <name>A0A2X0MJ56_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C037g11590</name>
        <name evidence="13" type="ORF">BQ5605_C037G11590</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="FQNC01000062">
        <property type="protein sequence ID" value="SGY93420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJ56"/>
    <dbReference type="STRING" id="796604.A0A2X0MJ56"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033865">
        <property type="entry name" value="Ataxin-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006155">
        <property type="entry name" value="Josephin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14159">
        <property type="entry name" value="ATAXIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14159:SF0">
        <property type="entry name" value="ATAXIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02099">
        <property type="entry name" value="Josephin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01246">
        <property type="entry name" value="Josephin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Josephin" evidence="12">
        <location>
            <begin position="42"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="236"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="286"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="366"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="408"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGY93420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="472" mass="52666" checksum="70727B84244EFB8F" modified="2018-09-12" version="1">MNLKALGENQCLGIYHSVLQRAELLPYIYHERSSSPISDDWGHHAINNLLQRAAFRPHDLALIACDSHPEPDEHDADDDDDDDDNEAVDEEKWLTQDRRNEAWKCHAPSRYTTPTVMKKTAGKYHIFFNSSSDFEVYKRHPEVLDAFMLTNESHWITIRCTLSRWIFPWLRRFGSSEWFYNLDSRLPQPGLIPRTELRQTLRMAKAIGYTVFVCEPTLGSGFPPCGGGQASTSNLNWMGRLPGSTSTSHNTLAMNGHLDPNLDPQPNDPRRSTTSSNGKGKRRMIDEEDLTDEDGNDDDVIIDDGDADEDDDVIIVEDSDRQNGGGGRMNPSTKRTRGGEAKRKKRRSDYGEGVGGGVGDDGSSSTPPTNMASTSNSSVSAAPTRKETSEEAQMSRAITESMKAARANSTSTSTSNQSPGPNSETTEDLELQRALKASLLDDVEVDEDDHALDDTPSMEELRRRRMNRFALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJK5</accession>
    <name>A0A2X0MJK5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C010g06026 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">BQ5605_C010g06034 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C010g06034</name>
        <name evidence="2" type="synonym">BQ5605_C010g06026</name>
        <name evidence="2" type="ORF">BQ5605_C010G06026</name>
        <name evidence="3" type="ORF">BQ5605_C010G06034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJK5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY14014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY14033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="60" mass="6833" checksum="8235BD6C3E277095" modified="2018-09-12" version="1">MKTRSRAAIQCTSTYMSHRSSKTAINLASRAHRRQALDVRRPPPSTACNAPKHSRRRSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKW5</accession>
    <name>A0A2X0MKW5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C033g11235 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C033g11235</name>
        <name evidence="1" type="ORF">BQ5605_C033G11235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000066">
        <property type="protein sequence ID" value="SGZ02923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MKW5"/>
    <dbReference type="STRING" id="796604.A0A2X0MKW5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ02923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="236" mass="27051" checksum="977969123F4ED24F" modified="2018-09-12" version="1">MTAKQTLRGTNSMFLNGDVQLFTPTVGPVGEAKGELPRCFMEIDDNDNNTLCESPPASEEEEMARLVSHAERDGSVCVVTDCTSHTYCWPVHIVPPSRHDVRVLLTRFARPALTRAITLQIWDKLGVSGRYELSAGLLLNLHFYTMFAHYAWSIYPLGVSLYFLSWSRFKSQICRALYMCFDRTIKTPLGKSPHGHLITRERFNIQNDTELPHDDLLRWHYRQCVLQHLRGIAILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLB1</accession>
    <name>A0A2X0MLB1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C031g10923</name>
        <name evidence="5" type="ORF">BQ5605_C031G10923</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="FQNC01000068">
        <property type="protein sequence ID" value="SGZ06168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MLB1"/>
    <dbReference type="STRING" id="796604.A0A2X0MLB1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="38"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="365"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGZ06168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="506" mass="55263" checksum="0CF759396C8BF6AB" modified="2018-09-12" version="1">MMAPSLTVATKCGPVVGYSDTYPLSNESTAKLDPARGGRPPVLKWLGVPYGQAGRWERPTPKSWTEPLECLEFGAKFPEPESLGGDLRLHLNIMASEGVTPDSQVAVLFWVYGGALNGGSSDSAMFDGTEWIRAQASRGKKFILVTASYRTNICGFFSGADVKAVDDLGLSGNYGAYDIIQALTWVQENIAAFGGDPNNVTLFGESAGAFLVSAMLVCGKRLFRRAIMQSGAAETLATFPLDQAYTAYPTILASHAPDAATSKDRIDQLRALPIDELIETHSVNYTFRGVALTIEDGPHAIWTENVIDRLERGEWDEWIEAVIIGTNEHEGSTAAVFLQADTTAGFSRLVSTTVNTRLYATPGAKLLGDQLFFTPVWRQARALARQPNKKSGRETRVYMYRFREVNDRLAKALPMNVGSAHALEIAFVFNVEVAWDEGSHESKTAAVMGSLWSEFAINGSPDPNWRPFTSEQPSWLAIETGGKTKNESLVDYQDTLVDFTGKNFAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLZ3</accession>
    <name>A0A2X0MLZ3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C029g10722 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C029g10722</name>
        <name evidence="1" type="ORF">BQ5605_C029G10722</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ16034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MLZ3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ16034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="114" mass="12259" checksum="8B52041A354A4DA1" modified="2018-09-12" version="1">MLAKLIPDILGGERLALDHLEIRIVDTLNDQGTGASVLLLQVHDHLGVGDRGIQTVHGPPLSQADVGGPHMPMLEDARIALALEVRLNSNRPQLVIILAELGYLDLPRLLSNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MN13</accession>
    <name>A0A2X0MN13_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C015g07964</name>
        <name evidence="10" type="ORF">BQ5605_C015G07964</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY18053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MN13"/>
    <dbReference type="STRING" id="796604.A0A2X0MN13"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000003">
        <property type="entry name" value="Peptidylprolyl isomerase domain and WD repeat-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000450">
        <property type="entry name" value="Peptidylprolyl isomerase domain and WD-repeat protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="9">
        <location>
            <begin position="568"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="25"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY18053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="712" mass="78614" checksum="10CFDB924B4D5910" modified="2018-09-12" version="1">MSSEATSLGKRAREIDAVDFEAPVVLEPTGEAATNGHRAEHQDGEPTAADGAQQLVGEEEDDDDDDFGPMPLPAGAVPTKKRKAQFMPPDLLGGCLNPVSTTVLAHEKLYLDHLPSADRYYKSFMHRDTVTGVVLTRTDFLITSSVDGHLKFWKKQAEGIEFVKHYRTHLSPIVAIAASDDGRSLASLGSDQGGKTVEGLEVKGSAKVFDVENFDMINILKLPFNPRICCWLHGRGDGRSLLAITDFDSSKILIYDGRGDGKPLHVLDSLHRKSVHLMAYNPLYDTVISIDVGGMVEYWEPREPFEKPDSVEWTNKSATGLYEFKKSKSTPVALSLAPTSNSFAVLSLPDLRLTTFNFLTGKLHRAYDESLTATQEMQQAGTAGVKMDSMEFGRRLATERELEKGALEAVLENRSGISVGAPVWDEGGKFVIYPTMLGIKVVNLPGLLVVNTVTNKVSRMLGKDETVRYLNLALYQGVPPKKGITTLAMATSENPLLNQTEERDPTLFCTAWKRPRFYLFTRSSPDDKSHDRDIFNEKPTRDEMQIAAPTAAAQGPLGKKAVIHTTKGDITFELFGDLVPKTVENFVGLARKHYYDEIIFHRVIPKFMLQTGDPLGDGTGGESLWGSAFEDEFHPTLKHDRPYTLSMANAGPRTNGSQFFITTVPAPWLDNKHSIFGRATSGLDVIHAIENVRTDKTDKPFDDVRIVSVDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MN35</accession>
    <name>A0A2X0MN35_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Histone H3-like centromeric protein CSE4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">CENP-A homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">CENPA homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BQ5605_C027g10291</name>
        <name evidence="16" type="ORF">BQ5605_C027G10291</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of centromeric nucleosomes, where DNA is wrapped around a histone octamer core. The octamer contains two molecules each of H2A, H2B, CSE4/CENPA and H4 assembled in one CSE4-H4 heterotetramer and two H2A-H2B heterodimers. Interacts with the inner kinetochore.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MN35"/>
    <dbReference type="STRING" id="796604.A0A2X0MN35"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000087">
        <property type="entry name" value="Probable histone 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45810">
        <property type="entry name" value="HISTONE H3.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Histone-fold"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="15">
        <location>
            <begin position="83"/>
            <end position="176"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
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        <location>
            <begin position="32"/>
            <end position="81"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SGZ28231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="181" mass="19508" checksum="5485F17A7D685037" modified="2018-09-12" version="1">MAVTPQRPTTGAAVKTNRPPGQVGLAGQALGGGLTGGKGRKSVPTGAGVAAKGRASTVGRKSIGGKTRPGQQTAGGKPKRFKPGTVALREIRKYQKSTDLLLRKLPFARVVREIASDFFDDDGQRVGLRWQASALMALQEATEAYLIHLFEDANLCALHARRVTIMQRDMQLVRRLRGDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNQ6</accession>
    <name>A0A2X0MNQ6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C054g12626 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C054g12626</name>
        <name evidence="2" type="ORF">BQ5605_C054G12626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000093">
        <property type="protein sequence ID" value="SGZ29352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MNQ6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="699"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ29352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="729" mass="79919" checksum="19540CC8B4C66B5F" modified="2018-09-12" version="1">MVRSFALVKIYGMAREGRSLVSGQYPRVKARLVSLYWIAFLSAPTAQQPALEIQPREDIRRCRGDEIAIYEPQSKKKKKKKKKKKKKKLQFHQKHDDLPACLVCGAPKDDWEHYFFDYVDSGNIWIAARSVLCNALGLDTIYNTHYTAVQRMFGLPKLKASLHNQEGAGRTIEIFTGLVLEMISSGRWGMQKWGTRTEGVGRRRIILEERLKLRAGGAWGRRGQRPWVPTAGTATSVQPPRDQIPVSSKKTQATGPATATPNYAAAASQVTQSPEQQQQQQQRAKALGSLLQAMGAVPGNRMDRWVQAIYFAKLYPVATATSLKSLALNANRSVENIFDYALEVTLSHQSASRASHADKTDLVACVTRLLLPISPICFEPGVPLPDHLAAYRPQILGVQHSSILRNGAAHHRVTVGFVTGKARDAALTTPPALTWRSAKARFAKSHRFHHNMDLSGKGHSCQLVQVLRIISVDNASAFAHVAGDYSAFLHFDDDSLFKRPNTTLKEILPSRIGLPTRGIPVTALRHDYEKEAACGRCHFVGHVGTCGLDQEVKRKEAHNANTNANKNTITNNTNIVEAEAPIPVPVVNRIASQNRFAGLEVEEGQEEAVTGQSGQGPEESGEEDAGDKADDEDSEDSEMASEATAKTEVIKLKSEDESVLEDCGGSDGEVVDEDEVMADGRGKTEGKVATEMEEREVATEMEEEEVATEVDDVDEAGGATKAENAEATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNR9</accession>
    <name>A0A2X0MNR9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Phosphomannomutase</fullName>
            <ecNumber evidence="5 13">5.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C021g09397</name>
        <name evidence="14" type="ORF">BQ5605_C021G09397</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>alpha-D-mannose 1-phosphate = D-mannose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11140"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="EC" id="5.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the eukaryotic PMM family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.8" evidence="5 13"/>
    <dbReference type="EMBL" id="FQNC01000083">
        <property type="protein sequence ID" value="SGZ21655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MNR9"/>
    <dbReference type="STRING" id="796604.A0A2X0MNR9"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004615">
        <property type="term" value="F:phosphomannomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02585">
        <property type="entry name" value="HAD_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1240.20:FF:000001">
        <property type="entry name" value="Phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005002">
        <property type="entry name" value="PMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043169">
        <property type="entry name" value="PMM_cap"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466:SF0">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03332">
        <property type="entry name" value="PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01143">
        <property type="entry name" value="C2.B.3:_Phosphomannomutase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01140">
        <property type="entry name" value="C2.B:_Phosphomannomutase_and_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGZ21655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="249" mass="28375" checksum="3889F24830319C7D" modified="2018-09-12" version="1">MSPVTPFSERPQGDVVCLFDVDGTLTPARRTASPEILEVLKQVRAKAVIGFVGGSDLPKITEQLAVHGQNITDDFDFCFAENGLTAIKLGQELDSASFIKFIGEEKYKKMVRFILHYIADLDIPIKRGTFIEFRNGMINVQERDEFEKYDKESKVRATFVEALKKEFADYGLTYSIGGQISFDVFPNGWDKTYALQHIEKENFKEIHFFGDKTYKGGNDYEIYEDKRTIGHAVQSPADTIRELKTLFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNY2</accession>
    <name>A0A2X0MNY2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C051g12550 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C051g12550</name>
        <name evidence="4" type="ORF">BQ5605_C051G12550</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000096">
        <property type="protein sequence ID" value="SGZ29597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MNY2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="3">
        <location>
            <begin position="64"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="671"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ29597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="714" mass="79265" checksum="15E8691DFFF3EA9B" modified="2018-09-12" version="1">MVDVLDTPPMFHDKLPYDAYCAAMFAEEDIKIPKTFEEAMKSPYCNHWSAAMVSELLQFNHHGVFQEVKWHKGIWVLGTIWVYSIKRNANSKIICFKARLVAQGFDQRPGIDYHDTYALVACSLTILFLIALAAAQGLYLEQFNFDCTLLNGKMTEDVYVRYPKGWNCPQSPGKCLKLHRAVNDLMVSRGFIRATANACLYIKHLGTSLAIITLYVDNGLIMSNNQSFLDSKLALLHKAFQLKHYILVHQSKYVRTMLEKFDFASPSKRRAVTPMDNCPSLRIDATPFANVSLYQSANSCPTLDNWAAVKRIFRYLNSTIDLGIIYQNSSTTQLMVYSDALFADDPESRRLVGAYASMLAGGVISWQSKQQSMIATSTTEAEILSASSATREAIWLRRLAGDVGIPQAQPTIIQEDNAACIQIAKDPVNHMQTKHFDIAHLFIREQVASGKVELEYCPTHINAVDIMTKPLGFQRFDQLCALLRMVSLVSLTGGSVRILVATNGGAQFGHGKLGLIEPAETREDLANWPNWSIWDIVTRLWNCIAASARDKFAHVRRKGKATGRNGDDGQTLAKVKVGYIFRAAMVLTVQDLMKTVKQALDKHKKETCGEVESELATMRSNPSRSKCPAGATGAGCSVAKKRAKFTDDATLQQLASATPDQINKTIATPLAKKHGRGNLPKHASPKTVATQPVSKTLGRLRVPTSDTEYYGQSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNZ2</accession>
    <name>A0A2X0MNZ2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="23">BQ5605_C050g12465 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">BQ5605_C050g12465</name>
        <name evidence="23" type="ORF">BQ5605_C050G12465</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000097">
        <property type="protein sequence ID" value="SGZ29649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MNZ2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0229">DNA integration</keyword>
    <keyword evidence="18" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="16" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="15" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="16" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="17" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="22">
        <location>
            <begin position="470"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="228"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="21">
        <location>
            <begin position="243"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="SGZ29649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="745" mass="82990" checksum="B28C0ECC3B7071A3" modified="2018-09-12" version="1">MVLAVARARGCCAGGPAEAAGCLHEIASFWPSCYEPNELPAAQESGEIKIAKLGKDNYELWSIRVEAYLESKGYASVLEHGHVRPSDVSLAEWRTMHGLDASVTDTQVVMVKSKTLSAKDIWDKLRQHHEGNAKPFKIRTLLMELSNAKYDEDENMGEFLKSMIDKADQLDDLALPPSYEMLKQAIRLGENRSVDHVINRLTDEYTERKLSGKFDKLLKNAGALAVQSTQASRDPNCYDAKKNHGRARNRNKKKKQDSKESADSNELAEFVLTVKSLDESHSLQDNVANRVSQLNQGEIWILDTGASQHYVGDASLLSNRQSGNLKVQTASGQVVHCDTYGMVRFKLKSGASLSLANVYHLPGAPVNLISTRALFKSGAKCGWEDGKDCTGYALDFTRIVEDQAHVATRATVGAPLMEWHRRYGHVPVSSIMELVKSGAVEGLVLTDEKVHDCEPCISSKSRASKFSELATQVTDVLQRVFMDIGFVAEDQVDFQGRKAYLAIVDQYSTAKWTFPLKTKSAEEVTRVWIAFRQGVEKMTGRKIKRVRTDNGTEFTNKLIGADFQSQGILHETSAPYTPQQNGTVERFNGSLMAIVRAVLAASKLSWKYWSYALAYATFVANRILHAKLEGKNRPMKYSMARNPRSRTFVHLDQPCMRKFRSQSDPNLKSTSVKGIFIGYNSEYNYRVLVDPDSDHKVIVTRDISGLGTQIRAGWCTGGHNSACGPDEEKGPVDNDEIVVDNFRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPI9</accession>
    <name>A0A2X0MPI9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C017g08451 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C017g08451</name>
        <name evidence="2" type="ORF">BQ5605_C017G08451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY20060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MPI9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY20060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="296" mass="31868" checksum="336F3BA5D8544424" modified="2018-09-12" version="1">MVQKMRKGSYMTSGWRPPRGHVDGRGAGPTFILYLRNAQGHNHLAQSINFDLSRSLSKSEVGQDGGHDHYDDAVTISNPILNDAFPFCSSTSSILFSTTNTLDQTLRFKGITSNTDLGAPRPQGTMSSLPQSVALPQEGASISASYSTTRDFPESIALRINVSTVEARSPSGHLVAGVAVRMSPSVPINFTAGACRFVYLQHLLDEVADALGIALQDDSCFDYSIVDQTDVSFAPSQTFISSRYVKLASFAARADFSDQVLESTSSALDLGTLPAEAILSMRDWNTPAYSHSGQDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPU3</accession>
    <name>A0A2X0MPU3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C001g00142</name>
        <name evidence="8" type="ORF">BQ5605_C001G00142</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY44321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MPU3"/>
    <dbReference type="STRING" id="796604.A0A2X0MPU3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000024">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00250">
        <property type="entry name" value="RNApol_arch_Rpo10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023580">
        <property type="entry name" value="RNA_pol_su_RPB10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020789">
        <property type="entry name" value="RNA_pol_suN_Zn-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000268">
        <property type="entry name" value="RPABC5/Rpb10"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003089">
        <property type="entry name" value="PRK04016.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431:SF3">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01194">
        <property type="entry name" value="RNA_pol_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005653">
        <property type="entry name" value="RNA_pol_N/8_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46924">
        <property type="entry name" value="RNA polymerase subunit RPB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01112">
        <property type="entry name" value="RNA_POL_N_8KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY44321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="69" mass="7852" checksum="1F719F4CBF4F3F6E" modified="2018-09-12" version="1">MIIPVRCFSCGKVVGDRWTQYLALLESGHTEGDALDGLGLKRYCCRRMVLTHVDLIEKLLHCELYPLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MS23</accession>
    <name>A0A2X0MS23_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C027g10426 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C027g10426</name>
        <name evidence="2" type="ORF">BQ5605_C027G10426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MS23"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ28728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="177" mass="19354" checksum="03BF225FD48016C5" modified="2018-09-12" version="1">MGNAVPEPDRHRANNVLDAQQAQTTKIAREEDRLFCHGSEGVVMPHEGDECLFESVDESDGRNVEREQVDDPRSDIRVGVHRASPWGNTSIRRCLQSSLCSVECRAPEEREIAVDGNRIASPSHALTSAHNSDPASPLVLSPAQAERESSRLGRVRASVCSQAPIDGEASQEIECCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MS59</accession>
    <name>A0A2X0MS59_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase</fullName>
            <ecNumber evidence="4 12">5.3.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">5-proFAR isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 12">Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C001g00942</name>
        <name evidence="13" type="ORF">BQ5605_C001G00942</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:15469"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="5.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.16" evidence="4 12"/>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY50942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MS59"/>
    <dbReference type="STRING" id="796604.A0A2X0MS59"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003949">
        <property type="term" value="F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04723">
        <property type="entry name" value="HisA_HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000110">
        <property type="entry name" value="1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011858">
        <property type="entry name" value="His6/HISN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044524">
        <property type="entry name" value="Isoase_HisA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02129">
        <property type="entry name" value="hisA_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090">
        <property type="entry name" value="1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090:SF2">
        <property type="entry name" value="1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGY50942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="253" mass="28337" checksum="C305D7E55570F353" modified="2018-09-12" version="1">MSIFRPCIDLHNGQVKQIVGGTLDTADLTTNFISEHPPAYYADLYRKHHLKGAHVIKLGPGNDQAAREALQAWPDALQLGGGITDANALAWIDAGASQVIVTSYLFPNCTFDEERLRILAEKVEKKRLIVDVSCRRRDNKWIVAMNRWRDLADMEVNEESLSLLSQYSSEFLVHAADVEGLCQGIDEQLVEKLGQWCNIPTTYAGGARDMKDLELVDRLSNGRVDLTFGSALDIFGGSQVKFKDLVEFNRRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MS85</accession>
    <name>A0A2X0MS85_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C053g12600 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">BQ5605_C080g12968 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C053g12600</name>
        <name evidence="2" type="synonym">BQ5605_C080g12968</name>
        <name evidence="3" type="ORF">BQ5605_C053G12600</name>
        <name evidence="2" type="ORF">BQ5605_C080G12968</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000035">
        <property type="protein sequence ID" value="SGY28275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000098">
        <property type="protein sequence ID" value="SGZ29871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MS85"/>
    <dbReference type="STRING" id="796604.A0A2X0MS85"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY28275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ29871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="335" mass="38801" checksum="D060D720F1334756" modified="2018-09-12" version="1">MIVPSNTKEPALRHEHVWARVGQKLKAKALLPKTAVRPARIPLKEDPHPRCFNFFGLTRPFTIRKLRRLVNTVRFPGKDGQDRALPGGQPQEPRVKRFPERTSQSGRQRFWSWLHDRFASAAEQDTHWRLMYDVTPTRKKQHVQGHASSPSCLFCGNDAAVIETVSHYFFGCAYSASYWSAVLRILFDKLGIEDTDLDPSTFIQEQLTMGLPLLRGRGRTTSKWMWVRLACAIGFQRLHLLRWHVHQRFEKDRVVAPPSIPSALRAFKRDFLSRAGFVPGARDWEWQSLFLDVGSASRKARSFYWIVFFARLPTAQQPALEIQPREDIRRCRGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MSJ9</accession>
    <name>A0A2X0MSJ9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C002g01067 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C002g01067</name>
        <name evidence="6" type="ORF">BQ5605_C002G01067</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY29572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MSJ9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032454">
        <property type="term" value="F:histone H3K9 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045109">
        <property type="entry name" value="LSDs-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12549:SF38">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING HISTONE DEMETHYLASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12549">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="5">
        <location>
            <begin position="1057"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="127"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="638"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1267"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1277"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1315"/>
            <end position="1327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY29572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1339" mass="143853" checksum="9CF4EA9602D5F722" modified="2018-09-12" version="1">MADSNEATGVGVTAIRSSPRGPATSSQPPSTSTSTSNSTSTSPLRKSHAATTTITTTAAENTHSQALNDILTNKLASLADLDVTALLGLAAQTPLLEPHQQTTPQFDLEALVASSIAAGLDTAESGMTASSAFEDSTSLAPPEANDGIDGHAYTNPPSPELNPIQYNAEDELKPSARPPSFAFAFSRRRRISTAPAAGPSSNTSAFTLAAASRFDDRGLDGDPSLMRSPPLIGQFTLANGQHGYGQGSIESTPNIVEIESSPVLSSNQTRPAFSVNASMMLNPENSSLFNPTAPLDEPPIASTSNLNAIPPLGPDGQPTVASLTISPMPFHYINFATPSMESSFERTPMLDDPDHFRSLNDAPTGDLESEKHRSAAADFSSTFTSAQVNEEAFRQHDAAKAARLLQYQQRMRQRMAAANAGNGKGDDESNLGMQSPYSGSNLGMSGWNGSDAARMRGPGGNLVRGRRTSSAASTLAMAVHAAKMQQQTPSIKDPTILPARPPHDLAPETRFNHIVLTTHWLDDNTSETISLSHLPEYRDLLDLPPEYLASQSLMDISNGLVPGLRDYGALRNPGPMSAPPSSITTQFPDLSFANRSNTWRSASMNYSDPALSALLPPPSTPMSTALTADALANGHTVMGSASALKRSRTSDGGSSRGSSKKKTKGGTNGRSSSPTPPPFEPTGEEPATWQLQSTTCLSKSIEGHPKCHLCLAIKSTPTEEFVDAVCAFRGVRSFGVDATGSIIACPTILSLDQDIATQLEEQPQFGQSPKKEQADELRTAIAPSLGPLLERELRHASSTRAVRVPRQLSTTVLCTTCLIAPLAGDWICEICGRAACSRCYEALVKLDEAIQDGTLDINGLTSDQHRRRRCLSHGKKRVSAHSHTQFTPLTRINRIEMQSLLADVMRWKAEHPVLSHNEAIPPDQIASLYSDNPILASERPGIVLAVSSLTKDLWHQVWARNEPVLLDGAPIQEGGLDKWTPETFVQKFGDVSLTLENHKSGERTPTLASYFFGMYGKTKRDTRSWKVRNFPAKGLREALPELSNAYLATVPLPELLRPDGVLNPLSHVPLNALEPEVGPRCAFTWAGRGSTLLHNHINLMTYTSATASDVPGSARWDIFRYEDSDVVRAFILELVAKKMAKAGTTKAHYRDAQDDPLFTENVFLDASLRAELFKSTGIRPYTIWQGVGQFAVVPAGCAFQVTTFDDCLSYAHEFISSEHVARSLQIDALSRSTKRSERANAHLAPSLYWAWQSVTTSLQPRQAQIPQYPSSDIIPNPTLSSTPSTYTALPPLPPIPDSTNVSPEALLPNPLPFVSSTSSSTLTEPEGAGAGTEEEGVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MT87</accession>
    <name>A0A2X0MT87_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C046g12272 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C046g12272</name>
        <name evidence="3" type="ORF">BQ5605_C046G12272</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000112">
        <property type="protein sequence ID" value="SGZ30921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MT87"/>
    <dbReference type="STRING" id="796604.A0A2X0MT87"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF2">
        <property type="entry name" value="FE-REGULATED PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="2">
        <location>
            <begin position="209"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ30921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="518" mass="56774" checksum="047B6C4A118775C9" modified="2018-09-12" version="1">MSALIGCGGVQPQRVLSFSPFLCTHESIFLTSKQTVYDPERPQNQAPYANMRNVIILGGSYSGARAAELFSQTLPITHRVILIDRQSNYLVNACPCGVRNLYLFPRFGVVPNHANKVFIPYTGVMASPGRSSSAPSSKSSSSTTEETESSRSGDSSDEGGPTRAQCVFIRASVTEVGPGFVEIDRDLDEETLGASVSDDDDIISSGREKWRRRRLNWDYLIYALGSTLPAPLLSPARTKVEGVRFLQAQQERIALSKSVLIVGGGALGIQYATDIADLYNNPANAALRPENSVEGKKKITLVHSRSRFLPLYKQEVHDEVTRRLDELGVDVIMGERLALPELEDDVSKQPLTSRRVESKTGVLEYDLLLRCTGQKPNSQLLKKSFPDAINSQGYVEVRPTLQLDSCNTKYADRMYVIGDVANTHAIRAGHIGWNQAGIVVQNIMSAVLCGHREPSLITYEPSPPQIKVTLGLRNSVSELLPSMGASETQVKMHSDGAVDAGWIHTWTRMGVDAQDPTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MUX8</accession>
    <name>A0A2X0MUX8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C007g04709 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C007g04709</name>
        <name evidence="9" type="ORF">BQ5605_C007G04709</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY62578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MUX8"/>
    <dbReference type="STRING" id="796604.A0A2X0MUX8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1010.10:FF:000006">
        <property type="entry name" value="Siroheme synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050161">
        <property type="entry name" value="Siro_Cobalamin_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790">
        <property type="entry name" value="SIROHEME SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790:SF6">
        <property type="entry name" value="UROPORPHYRINOGEN-III C-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75615">
        <property type="entry name" value="Siroheme synthase middle domains-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="8">
        <location>
            <begin position="414"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="297"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY62578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="712" mass="76547" checksum="FC466A5229F814F4" modified="2018-09-12" version="1">MVAYPDPQPGASLLLALSAPIASSSSSSSSTTPTPSHDTLLLLSPSRISALRAFAALEAGYRIVVGASATHQWDAELAWRKDQGQIETIEWSIPFDADESAWTHWFDQVLPTSISSRCLLVVLGDTMTTISATQSSSSRRRSFSSARAFKRIANERRYLVNIADAPTLSDFTWPTTHRFPLDSAAPSSDKSPLQLALTTNSSACRLATRLRREVVATLPSNVGAGVQAISKLRVSLASSMGGSEVAWEKGDSEEVELAGVRFNRPVAQLTREESKELDRLSLVDSTQGVEAAALEPQLRSISQCRGRTRRETKGEEESTTSRSNSSVSTVSTAATSTILSTQAWTAAEAQRTRMRYVAQVSEYWPLDRLATVTLSSLSSPSTPLASTPPEPETLLANPSHHSLLLEPPTRGKGRIILLGTGPGSPLLLTRLAHLLLTSPPGSQYHVDVFLSDKLVPSEILALIPSPAREGVIIARKYPGNAEHAQDELMRLAVEGAKAGKTVLRLKQGDPFLYGRGGEEVLHFRHAGFEPVVVPGLSSCLAGPTINGIPVTQRGVAETMVVSTGVGRGGKELGVEPYERAKTLVVLMGVARLDSLVEALLTHKEAAYPPYLPIALIERASSPDQRVVCATIESLSDVLKRLSPHRPPGMLVIGWGVMCLEGTEGKGDMTVLDALADEATDRKRVEGWLGDNGYRVREGLGEGWRALTEGKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MUZ6</accession>
    <name>A0A2X0MUZ6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C062g12757 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C062g12757</name>
        <name evidence="3" type="ORF">BQ5605_C062G12757</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000138">
        <property type="protein sequence ID" value="SGZ35545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MUZ6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="486"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ35545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1235" mass="138674" checksum="575A8928D0F96B6F" modified="2018-09-12" version="1">MMNVFYKKKKKIPHVLTLIPDGSPLAGRLLSSTPVVFAEAIQFDGRILRSVFRLEELDIEIINMYAPVKGEERRDFFGLLHFNAPRPKTLRILAGDLNDCPDVSVDRVSITDRAWTPVSHWQTLLSKIAFKALDTVRHVHSCTPAFTRPHYRGRGEERKICSWSRIDYILVQCSWANRLLSASTLFDAPCSDHRPVVATFALPTSNADAEPPLSLPSTSDFISRLNPTVFDDQDFVASIPGVVDEVYRRLEGTAPLGDVYDAALRAVAVAGHARYRSTRADMRRLRAESQSVMEALEARGEHMNEAERDAYAFAKSRLDQLAVKEAQWLRIRAHVPSVDSREGQSASIRTRLNRRSRQTSIVSLEDVDGTETVDMQEALGIASRHAQSLFTPDPARGDPTNPRRSLLDPIRAAKCYDDDRSDPTFGRRLPRQARVALDEPFTLLEVEAALKKTDSGRSPGPSGIPYELFKALPTYFAPKLLDLFNSIWEGGKMTASLAEGLVRLLPKNKPGANLKSLGAYRPITLRETTYKVLSKVLVARLNGVLGELLPPAQHGFMPSRRSADAGKGALLSLDQQSAYDRVDHAWIFDVFEAFGFGERFISLLRALYDPETLGVRYLINGFPTELVRLLCGLGQGDPLSCPVWNITFQPFLDALVRRGIALDLQKVWPGGPRAQLTHLAFADDAVVVVESPAALSKLETLSQTWYEATNGKTNTDKTLVLPLGPNWLRDETAQALPTVQEGESFKWCGYAFFRHGDSKLFWTHVLDRIKAKTRAAGDRTLSPSGKVFYANAHIISTVLHVLSFDIPPQWFIKAAETALTDFVWGGAGRNTVARDFVFQAREDGGLGLISIGDIVHSVALRFWDAVAGSNEAIWAPLARESWRSLVAATRDFSPWGFFSSTARVEKLYRDSTRWGAVVAAARVTVPTIKSELLTLPELLSLPPRLPSLYAEGAKHAYDDADAVAKFAQIADLYWRDEGKGWALVGHRRGFWQHSKEPALQHEHVWSRVGQLLKAKALLPKTALRPARIPLKEAPRPRCFNFFGLTRPFTIRKLRRLVNVVRFPGREDRVKRFRDGTSQSDRKRFWRWLHDRFASAVEQDTHWRLMYDVTPTRKRQHTQGHASSPTCLFCGNDAAVIETLGIEDTDVDPSTFTPEQLTMGLPLLRGRGRTTSRWMWVRLACAIGFQRLHLLRWRVHQRFELDKVVAPPSLPSALRAFERDFLSRAGFVPGARDWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MWB5</accession>
    <name>A0A2X0MWB5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C004g02922 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C004g02922</name>
        <name evidence="5" type="ORF">BQ5605_C004G02922</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY68825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MWB5"/>
    <dbReference type="STRING" id="796604.A0A2X0MWB5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000064">
        <property type="entry name" value="GNAT family acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051016">
        <property type="entry name" value="Diverse_Substrate_AcTransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545">
        <property type="entry name" value="DIAMINE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545:SF29">
        <property type="entry name" value="GH14572P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="27"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY68825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="166" mass="18551" checksum="5F22200A3B3C2EDD" modified="2018-09-12" version="1">MAYHFVLVTPSNSSSTLPQTLELIQALATYEKEPDAVEATLPLLRRSLFGEEGKGEEGKGGKYAQCVLVYEEEEGDSKPLGMAVWFYTFSTWTGKGGLYLEDLFVREEARGKGVGKALFKYLGQICKDKDLARMDWVVLDWNEPAKKVYQAMGAQHASSSRRLELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MXF2</accession>
    <name>A0A2X0MXF2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C001g00324 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C001g00324</name>
        <name evidence="3" type="ORF">BQ5605_C001G00324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY45701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="765"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1362"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY45701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1439" mass="159218" checksum="A66A2E3AEB413DC3" modified="2018-09-12" version="1">MSPSQKKKKKKKKKKKTACDTNSRRTTAAYAIAPATNGAPAGSQRSTSVSGPSAPVPGARTSTSTPTPTGGFRVAGKNGKDGGPTPLTSRASGTNMIQLGPRTNPATDLASANDTDEDDNIDGASVASTEPEGDDTGDATSTNATAGSENRTQTTAAAPPGFDFDFVYDAALTLADGYGIDAVFAFDLDLDIEPDFDFDFVFAFVRWHVGNIGNHDLHESETPRDSSFNLGTRQPTCHPGGIRHDPQFLGGRRSWGRQFRGFQSLTVLTFNVRSIKNVVDQVKIIRYLKSLRPAPAAILLQEHHLSFNALREGFESTWPGGCIQAPQFNGRILRSVFRLDELDVEIINMYAPVKGEERRDFYGLLHFNAPRPKTLRILAGDLNDCPDVSVDRVAITDRAWTPVSHWQTLLSKIAFKALDTVRHVHSCTPKFTRPHYRGRGEERKICSWSRIDYILVQCSWANRLLSASTLFDAPCSDHRPVVATFALPTSNADAEPPLSLPSASDFNSRLNPTVFDDQDFVVSIPGGQRSRGTCGIGKLARAWRGAGWRQMAGTAPLGDVYDAALRAVAVAGHARYRSTRADMRRLRAESQSVMEALEARGEHMNEAERDAYAFAKSRLDQLAVKEAQWLRICAHVPSVDSREGQSASIRTRLNRRSRQTSIVSLEDVDGTETVDMQEALGIASRHAQSLFTPDPARGDPTNARRSLLDPIRAAKCYDDDRSDPTFGRRLPRQARVALDEPFTLLELFKALPAYFAPKLLDLFNSIWEGGKMTASLAEGLVRLLPKNKPGANLKSLGAYRPITLRETTYKVLSKVLVARLNGVLGELLPPAQHGFMPSRRSADAGSHLTLLLEKLKSLGTEVFPEGALLSLDQQSAYDRVDHAWIFDVFEAFGFGERFISLLRALYDPETLGVRYLVNGFPTDLVWLLCGLGQGDPLSCPVWNITFQPFLDALVRRGIALDLQKVWPGGPRAQLTHLAFADDAVVVVESPAALSKLETLSQTWYEATNGKTNTDKTLVLPLGPNWLRDETAQALPTVQEGESFKWCGYAFFRHGDSKLFWTHVLDRIKAKARAARDRTLSPSGRVFYANAHITSTVLHVLSFDIPPQWFIQAAETALTDFVWGGPRRNTVAREFVFQAREDGGLGLISIGDIVHSVALRFWNAVAGSDEAIWAPLARESWRSLVAATRDFSPWGFFSSTARLEKLYRDSTRWGAVVAAARVTLPTIKSELLTLPELLSLPPRLPSLYAEGAKHAYDDADAVAKFAQIADLYWRDEGKGWALVGHRRGFWQHSKEPALRHEHVWARVGQKLKAKALLPKTAVRPARIPLKEDPHPRCFNFFGLTRPFTIRKLRRLVNKVRFPGKDGQDRALPGGQPQEPRVKRFPEGTSQSGRQRFWSWLHDRFASAAEQDAAGCLHEIASFWPSCFSLFSTTHSISHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MXI8</accession>
    <name>A0A2X0MXI8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C001g00364 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C001g00364</name>
        <name evidence="25" type="ORF">BQ5605_C001G00364</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY45954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MXI8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="346"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="586"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="633"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="690"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="595"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGY45954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1232" mass="134217" checksum="4C9B9221F47810BA" modified="2018-09-12" version="1">MIKKAVAAGTVTDIFIKLQALLDAGPPPSGVDAFEKYQANTIELFNTLSGYNLTFDQVISIRLIHFGKDLYKEYYTQALRQDLDKLPDPIEALQTLQTQAESTPAHKPVAMVASLTATDRSSSTPSAPCRHCGGPHWNRKCPVKDKKSKASSAPSASLAAAPDISTLVDGPVRGYLTAAMSTLAKPSLILDSGATHHIVNDRACFTNFRKCKPAPLEGITGEAVNSIEGVGSAVVRSFDGSIGQLHHALFVPSAPVSLFSASRANAAGYDINLSRGKATVSVDGSICHTGEITNGLYHMHASLVDVTTLIEQPVNMEVALNADLKCDTCQAGKITHHPFPTVASNRSAQPLDRVHMDLLAFDGAVSLGGAKYALVIVDDYTRYLWAIPMSHKSDTFAAFKSWLAKVERSSSRKLLAVRSDNGGEFLSNEFSSFLEEQGITRQLSIPDTPQQNGVAKRANRSITEGVRSMLHQSGLSHALWAEALATYVYVKNRSPHSANSGVTPHTRWHGSKPSAGHLRVFGCRAWKAATTEARSKLDPRGIPLVFVGYDLESKGYRLFDPATRQVFKSRSVTFFEDEFPARREGITAAHAPVAGDDDDDDDDDDDEVVVLPDQHANQAPPDQAELPAALRFDAPGPAWQPPVGSRPRNPPARYGALASLRSTPSAFAFSLGKEVTELVADLEAAGIDTSTANRPLSEPEDPFSLPSSDPTTWNEAMRHPHAAAWKAGAIEEFRSMKDDLKVFSVVGLSSVPKGATILPSRHVFRTKRDKAGKMVSLKNRIVAQGCAQGPNSFNNTFSPTAKYTSIRTLIAHSASKGHHIIQADVDKAYLHGVLEEEIYMRVPTGIEGYEGKCLRLHRSIYGLKQAGRVWNDTINATLASLGYRCLACDECIYRHEDAGGDHYIALYVDDLLFFGPDLGEIDRVLDQLDTLYGVKRLGPAEWVLGVQVVRHDDGGISLLQRQYLLDVLARFNMSDCNPCKSPMEANLQLSPEPDTDSADNAIYRSMIGSLMYAVVATRPDLAHSVGYLSRFVGKAGNTHLEAAKRVLRYIKGSLDLGIHYTRTSAPLLGYEGYSDSDWGSDIQTSRSTMGYLFKLAGGAISWSSRLQPRVACSSTEAEYLGLSHAAKEAVFLRSLLTELGLDTSSPLRLLGDNQGAIALTQNPVFHARTKHLRMLEHFVREHVRNGEISVTYIPTHDMVADIFTKPLPRVVFQRHCDAIGLRRISGQEQGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N1B9</accession>
    <name>A0A2X0N1B9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C039g11760 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C039g11760</name>
        <name evidence="1" type="ORF">BQ5605_C039G11760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000060">
        <property type="protein sequence ID" value="SGY89634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N1B9"/>
    <dbReference type="STRING" id="796604.A0A2X0N1B9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY89634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="105" mass="11949" checksum="D3A3D92E5F2C4674" modified="2018-09-12" version="1">MGRRGFDRRFPRALDRSWCGPAVLVPLVSTDKSGQGKTLLANCLVFCPEWITGNKNLHTSNWLHFCWVFIPLWIMHDSYGYIVHSLRDPAGYAAELTRGMRPSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N1X8</accession>
    <name>A0A2X0N1X8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C007g04741 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C007g04741</name>
        <name evidence="2" type="ORF">BQ5605_C007G04741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY62826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N1X8"/>
    <dbReference type="STRING" id="796604.A0A2X0N1X8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052945">
        <property type="entry name" value="Mitotic_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628:SF1">
        <property type="entry name" value="CHITIN SYNTHASE REGULATORY FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="520"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="857"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="886"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="952"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="385"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="462"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="672"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="692"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="766"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="967"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="983"/>
            <end position="993"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY62826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1196" mass="128965" checksum="88B07D2B9A82608F" modified="2018-09-12" version="1">MLGPQSARRLPHAHAQAAQGYSLTTYSNNDDEYDEYIRHDGRYNGPHDPQRSTYSMNATAAAANPTPVQHPRRVRQDTREPTTANARHGPSCSPTSPQEHTPRTSSRPASPSYRDAMPSGSHNREHLGASTSSAPSSSQQATASISLAPQPRSRESSKNAVEHHHIYPHHHLQSNYYGVGTSASELDRLDSTRRLMAQLDPDDAESIAPDRGTWASDWRESEIDRDPNRSSFEVDEAAHRSLGQVYTTRTGAGFPRNSSTSVVTVDGGDPFPYSAYDGMPLYDDSIEPEILASFPIASTADNHRPSPQKLIPPRDGAGAESQHGAHAPSPGPLRIGDNSPSTETFLSDSRALLVSTPTRETSFGPEESSRAIRPDLITVPPHGASPPTLSGSSSPTWSVAVSQTGRVASRTSARNFSRPFVAVAEPTTPNELAVPPLPPQYGRNQVSRSDSSDSIDQLARQSSLGHSSSIGHSTSGHESSMGHGASSQGGHSLSSSWEERRLMGLKGVELAKREMLLKSHSGAMERLQEEERDQSTERRGRYSGSSRESSPESKPHLPIPAASPVMARQLPAISFSTTENSGSMYPERSSSTRHDSPIDQSLHSHQRAFDRDASPTSPSPRTLPIAPSQGQSPSSPHLSPCLNPTGSSAEPRVSLLENPRASPAPPLHLLNSPASSSCHSGLDSQSSSPVEAQSAQMPSPAASPPRQRNVLRKRRPSDASARAKDGITPPPEGTMPSLPQSTALAIEVALREDPFAASEGQSGRWAKFRSSRSHSSKSKIRPSYGPEADTAAEYEREADSASVPHITFEPPSRPTGDLRDLALRAKQLSEQRHALEALSLKPSVAKSAAAGIVQRGDGRDLAPGWVQKKGDWDPEDEMESLAVKSVIRPPGISPKERSVSDQGPQRLYSDASEENGLSVLGSHARPGTAASLYSNYSFYSLPTTMGASVFGGSKPGSIRSPTETEHSPSSPRAPSSMSISHPTFEKAKAGRKVEMTTTPEGEVVPRNEPQTCEDYLILGIHYHENGELPRAAWYFEQSAKQDGGCPAGMLMHALTLRHGWGCQVNTQLGFKYLQAAAESVVEDIDHEKAGDHSLLDTKASKNELVLALHEIGVSFRFGWGVPRDKKMPSLSTQAVAYFTLAADLGDVDAQTDLAFCYANGKGCKKDLRMAAHYYRLAVKQGAESFGLSWIWKAKYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N9I4</accession>
    <name>A0A2X0N9I4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C027g10370 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C027g10370</name>
        <name evidence="1" type="ORF">BQ5605_C027G10370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N9I4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ28551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="141" mass="15967" checksum="14A6507807CA2153" modified="2018-09-12" version="1">MPSRIDVGHLPHSRPNIELTTAFRRWKILPRSAKVSTKRRSSQKRAIDMRLITSFSSTFASLTRVVSTSVQDPPCAFSATAIFKGECSVWTIIFFNEAHIYRSLLQTGDSKSRLTRHRSNLFHLGPNGSCIVFLVSVMRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NH52</accession>
    <name>A0A2X0NH52_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C048g12366 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C048g12366</name>
        <name evidence="3" type="ORF">BQ5605_C048G12366</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000110">
        <property type="protein sequence ID" value="SGZ30456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NH52"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="2">
        <location>
            <begin position="150"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ30456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="220" mass="24836" checksum="982FF6F2E0D80B25" modified="2018-09-12" version="1">MSFRQATPLSFGPGTFGRARALSKLWPHHDPFGLVGFCVERDLKISLDELIKHLLNLYDSDFDATPTPPPPPRNGTIPRSGPDLKSRIRFGMHFKSLRRFQIGGPISGSSHFRRGDKRVACRVFKEKVARIAAALLENDMDVVSEMIKKSKDTKRYKATTEAEKHINRILAELQSVGDKIHGTTAQMLDMRNEIRGYVNAFSMYTLFVTVNLADLHSPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NN99</accession>
    <name>A0A2X0NN99_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="10">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">BQ5605_C013g07083</name>
        <name evidence="15" type="ORF">BQ5605_C013G07083</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="10"/>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY14750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NN99"/>
    <dbReference type="STRING" id="796604.A0A2X0NN99"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17941">
        <property type="entry name" value="DEADc_DDX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="45"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="76"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="281"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="556"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="636"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="759"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="45"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="571"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="591"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="672"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="759"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="784"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SGY14750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="879" mass="97751" checksum="895E6EF60F110302" modified="2018-09-12" version="1">MSARPQSVNNKQNKPKKISRKQSERQELQLLQQRVDDFVAPDELQLFAELPLSSPTLQGLKSAYYSKMTDIQIKALPLALKGLDVLGAARTGSGKTLAFLIPVLEVLLRKKWGPNDGLGGLIISPTRELAVQIFDVMRKIGHKHSFSAGLVIGGKSLKDEQDRLARMNILVATPGRLLQHMDQTLGFECDQLQILVLDEADRILDMGFQASLNAIVANLPKQRQTLLFSATQTKSVKDLARLSLKDPQYVAVREGMASVKGKEKAEDGAEDFNSAQATPKNLEQHYMVVELNEKMDVLWSFIKTHLFTKTIVFLSSGKQVRFVYENFRHLRPGVPLLHMHGKQKQMQRLDIYQRFISAKHSILFATDIAARGLDFPSVDWVVQVDCPEDVETYIHRVGRTARYVSKGKALLFLLPSEEAGMVKRLEAKKVDIGKIKANAAKRQSVQSQLQNAAFQFPEIKFLAQRVSSVAVGDVPCTTDMAKRFFPQAFISYVRSIYLHKDKTIFNLDDLPLEAFAISLGLAGAPRIKFVSKQAASVKKNAVRQIEVLKKDARIKVAGSDHENDSEEESEGSVSRSGSHSGSGSDEDEISGGEKSEAGDDERTTANAPDVKEKNGGVKTKYDRMFSRKSQTILSDHYSKLVDRSSDEEDGGAGRTALTGDHGADGGDGDDFITLKRRDHTIDEDQLPESHFISKRKLKMGQSKKAMLNKHGNPTKLVFDDDGEARQIYALKDEEHFKAEGDAAEQRAKFVEEERQRLAKADVLDKERAKEKRREMKRKHKDYDGAYEDEGGVEVGDLSDVDDGYVSPDFNLLDLGTSEEEDGPLWYKAQDRNTAETSATPAPSEKRNKRQRRNGRSDASAAAEPAVDLEALALQALGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NP13</accession>
    <name>A0A2X0NP13_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C013g07343 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C013g07343</name>
        <name evidence="7" type="ORF">BQ5605_C013G07343</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NP13"/>
    <dbReference type="STRING" id="796604.A0A2X0NP13"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF314">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="10"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY15355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="455" mass="49624" checksum="48B1CE3AE7483CA8" modified="2018-09-12" version="1">MSPATSNFRICIVGGGIGGLTALIRNMPLANDRAIFLRSEGREIVVLEQSRMLKEVGAAISLQPNASGIFERLGLGEDLKKAGGIIDNGFQIFRTDGIRQLQVPSKRETNNGYDRILFHRVDLHGMLKDVATREDSEKGPAATLRLGSRVASCDCEQGTISLESGEELGPFDLIIGADGIHSKIRDSVLGEHVDPIPTGLSAYRLSVSCESRASYSRAWTDVAPLITPKIPRDNIKDLPHAYAQCTQEPWTSMLVGQACRAIMGPCRNGELLSIVALVPDDQLHEQSTDSWTSSGSLEHLLESFAAFPEWTKTLFSRSPSLGLWQLRDLDPLSRWNKGRVILIGDAAHAMLPTQGQGASQSIEDAEALGAFFKGISSQPSKSEVEAVLKRVYDVRHERATLLQKYSRQQGKPAANSETLEVTLNPAEFHAYNVGYNGAVEWEKKMASENALATAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NR79</accession>
    <name>A0A2X0NR79_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C014g07426 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C014g07426</name>
        <name evidence="3" type="ORF">BQ5605_C014G07426</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY18648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0NR79"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1268"/>
            <end position="1553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="651"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="711"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1847"/>
            <end position="1872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="713"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY18648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2091" mass="232241" checksum="6AB17B18147314EC" modified="2018-09-12" version="1">MQTGDPGSAPGARAPPPPASAPTSLPIAGTKETQATQVAGRTATYAAATNSSVVLNETPAQQQDRLARLQALPGILAAIQAVPGNRADRFVQAIFATPDFPSTVATALKFSALNATRNIINPFANALEVSLSHKSTGRASATDKGELVACVRTLLSPNTPICFDTGVPLSGDLEAFMPRITGLQHSSTFRTGVLHHRITVGFVSAEARDAALASAPMLVWNSANARFAKAHPFHRNMLEMRINVGVVRPPSKEQIVAAFQSIVQQLSTKGHSCQLVQVLRVIHVDTAKAYAHTVGDFSAFIHFDDASLFQHPTTTLKEILPSRMDLPTRGLDVTAVRHDYEKEAPCARCHFAGHVERCPLMQAANRKEAEDLARHAVMRGAGMVGGGEQTGVGRAATTTTNNIRPTANNNNTSEVVAPSRALGTDQLESRNRFAGLEVEGGQEDDIEEEVAGKEGEEKEQVEEGDEDTGAKADDEDSDSDGNAGAGIDKAGGDGKDDDKDNDEHDDKDEQDDSSEGSERRGDDVMKDGAEEEDEEMETEVEEEVEQEQGVQDDSIMIIDDGQTTITTVSRESTPRSPLWPPLSPETLAKSLREGAEWDRANAEAAARVQAENEAIINAQLDAQEPLVRHQFAEWGQEDGQLRFINIRGTGSRSNKKMKRSQTVADLSDPSDGPVDVKRVLNRVKGRAGKEVAGQGKRVTRSMSAAAAMQVEGAKAKAEKGKGVEEEKRWSDHEPEDNILPEFPLFEDNITAKSTWNVRRCMGIPEKRRDIYTYLSTFKASAILLQEHFIKPELWQCIKDEYEGKAFISKHCLTLIPADSPLIDAEILRTHSALDGRILVTSFRLRGDIRILEINNLYAPVDTKQRLTFFDKLHFHRTQSTHLRLLGGDLNDCPLPAIDRRNQGRHGHHWPILIGKLDSPYTDCIRFKHPLTPSFTRPNIVRKRPKSFSRLDYFLLQRTHQKRLVQASTIYDHPKDLSDHRPVSIVLVLSDERGDAAEPNNSLPTTSNQLHRINAATFKTAAFQGMLEGWLEGASGEEPVGELEVVLGNCEKEGRELARREHRERVERMAVLVGRVQDQEALPVMGDEETAEWTRTTEELRRAVNERARQLRIRAHVPEIATEERLSRPVHAKLAARSSDSKITALRLPNGELTHDIDVALDHTQAHFQRLYNLEPRDRDHVERLRDDFLAPIRAARTCDDPSSDPLFLRRLSEAHIELLQQPITEDEVVAAIATTHPGRSPGPSGVPYELYHTAPRAWAKALSRAFNAMTERGSLSPRQGQGLVRLLFKHHKIGADRAELSSYRPITLRECEYKLFTKVYVARLNHVLPDLLPPQQHGFVKGRRSADASFHLRLLIEELGARGTEFPDAALLSLDQSSAYDLVEHEWIFAIFDALGAPATFQRVLRMLYSGDSTTARYIINGFLTPPVRLTCGLGQGDPASSSVWDVVFQPFLDALHRRGIALNLSLPTIHPYPQSRAITSLAFADDVVVAVAGSESLTLLDDLALDWRLATNGRLNTDKTVVLPIGCRWEAGDRPLVVKAEGESLEWIGLSFDPTGNTELANVNLVARLEAVLDSARDRGLTHHTRAFYVNRYAIPKILHILSADIPPLEVVKELDRILVDFVRGGKRRSCYGKDVVFTPRFKGGLGVMRMQDVVDSVAARVWDVLLGGSDAIWQGLARAAIVRAHPAPDFDLATDAWPCDYTPIRTDLHPRWQAVLKVPSTHNAQVKPRTLTLANLLALPIKLHTLHYLPGAPAVSRSPYDVDYAAFAIYAKVADLFRRELYPGGGFHLWTPPTDVVVSNSEYDQRGRPQREHIVAWYRHAINRLRFTPIAQPVAAVRINGPPRVRPRSEVRPTTPLESILPHPIDPPQRLPRPALPDQSTQYNLLSMDRPYTIRRVRRVLNAKAFTDTIGFRDSLQPDDLKGFWKGVNSKALTAREREVWFKLVRNFTPTRSLQFHQKHDDSPACLVCGAPKDDREHYFFDCVDSGNVWIAARSVLCDALGLDTIDNTHYTAVQRMFGLPKLKASLRDQEGAGRTIEIFTGLVLEMISSGRWGMQKWGTRMEGVGRRRIILEERLKLRAGGAWGRRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NTR6</accession>
    <name>A0A2X0NTR6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C013g07067 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C013g07067</name>
        <name evidence="1" type="ORF">BQ5605_C013G07067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY14734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NTR6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY14734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="84" mass="9581" checksum="6C9CC2479503400F" modified="2018-09-12" version="1">MINKRRRTVQGLLTPSTRCFGEVRTIERLVCCERVDLAIEEPTILALDVDLAEASDETFSRIRRARSVESSGMRFEAKDPQPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NTR8</accession>
    <name>A0A2X0NTR8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C010g05846 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C010g05846</name>
        <name evidence="7" type="ORF">BQ5605_C010G05846</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NTR8"/>
    <dbReference type="STRING" id="796604.A0A2X0NTR8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051485">
        <property type="entry name" value="SR-CTD_assoc_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140">
        <property type="entry name" value="RNA PROCESSING PROTEIN LD23810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140:SF0">
        <property type="entry name" value="U2 SNRNP-ASSOCIATED SURP MOTIF-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="277"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="SURP motif" evidence="5">
        <location>
            <begin position="440"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="CID" evidence="6">
        <location>
            <begin position="526"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="369"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="717"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="775"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="384"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="416"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="719"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="790"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="851"/>
            <end position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY13366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="861" mass="94803" checksum="E5CD1AAFC5281755" modified="2018-09-12" version="1">MAPSDLRDPRHLLAARDRDRDDDDDPANGGSTTGAVPASEVVGASKLASYDQGVVRKSKREREAEAQQLKAKEQEQLAAKAYNDFMKDFGGDDDDDDSGRHPSSSSRSGPRGATRGKYSAGKAFVSAGGGQRYNPLQDRPPPPAPAPTASTSSLPSVVGAPTAPRAMRLPEPVQAKSSAISDEETRPSASTSKSGVVLGKKRRDGDSFLEQLKRSIHSPPLPCVLCRRLVVSMEQAEREERLKQKADRLGSSVTALAARENAPVLTGSYDTGDPLTTNIHVSPLPQNVTEDTLGMFFARYGPIGSVKIMWPRLEPGATLVGRRQLSGFVAFMRRPDAEKAAKELDGVEWGGTVLKLSWGKPVPVPTRAVIDIEGSSTRSDRQRERLHRPSRRRSSSRSRSRSRSRSRSPKRRHRSYSPDDERAHARREWPTLEAGIEEKFLKTIANRILEHGSAFEHALREKERHNAKFDFFREDKLPSYHYFKMLLDRHYRAPMPAKFDDVGPAEVYSSDTEEDSENERILKGRLGTLARKRFEALLRTLTSTRGNIARGMAFALEHADAASFIVDLLIASLTLEATPVPRKIARLHLVSDILHNSSAPLPNAWMYRSTFEERLPVVFDHLGEIYKSFPGRMKAEQFRLQISSIVDVWERDWMLFETRVFDDFRRRLAGVSEQPTEETSIEPEVVPSTEPEALITASAHWAAVSSAFKPATVITTGPIAPPTPRPPSPIPGLAAPPAKKPQIKFGGFKTAFTPTTGLPQIPVEDIEAVEIEMEARPAGTSKDPTLAAEPNDDDGEAMEIEDDDEDDEDVDGVPWEGQDSEGDDVDGIPLEGADVDGSPLELEDVYGNPIDADDMFEGPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NVS2</accession>
    <name>A0A2X0NVS2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C013g07328 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C013g07328</name>
        <name evidence="3" type="ORF">BQ5605_C013G07328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NVS2"/>
    <dbReference type="STRING" id="796604.A0A2X0NVS2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23024">
        <property type="entry name" value="zf-HIT_ZNHIT2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039646">
        <property type="entry name" value="ZNHIT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15555">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN CONTAINING PROTEIN 2 PROTEIN FON -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15555:SF0">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="2">
        <location>
            <begin position="32"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY15327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="448" mass="50665" checksum="C9B4D028096F309C" modified="2018-09-12" version="1">MQGRIRFGPKKGINTHAKSCASPIVSGPQPVCQACQTQFSRYTCPSCNFHYCTLTCYRSPSHSTCSEAFDRQSLVDEIRSSQGTNREEQKAMMEMLKRFEKEQGQENEAEEDDEVTTQRMLDKLKGVDLDSIEPSQLLEYLSPAQRAEFEDLLQVSTKVEALMEAHDELKKPWWEETEGVVVEEDEENKEEENAFTKKKTIRPAILPPDSLPPLKLGEDGRPLVDPGLLNNIVAVLLAYVYVVRTYSLSSLSTLIPSTMDHQEVYRVLLHLVPFLTTHSTFIFSSIKEPIENLFKTESQEDPSTIFQITQDVAHLLTPLPVINVHDHPFSNALTALADLETFFGSFTRAEGLNTKGIKAEVKQASMKLRFYYAFLARLGEGDSVLRSLGEEVERVGRGVAGMWEMKRIESERKGMEGKQRSEKVVGERRGPIIEEIAEEEGDRKVKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NWE0</accession>
    <name>A0A2X0NWE0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01474 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01474</name>
        <name evidence="2" type="ORF">BQ5605_C002G01474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY33270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NWE0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY33270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="71" mass="7774" checksum="1480E16E74DEBB5B" modified="2018-09-12" version="1">MVIEPQVRKPLGACPSTTDFKSAFPVRYSDVGRIDPKGHFSEEYDDRTGGQASSKMHMKVDGAFARKNGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NYR8</accession>
    <name>A0A2X0NYR8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C009g05578 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">BQ5605_C009g05581 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">BQ5605_C017g08363 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">BQ5605_C017g08476 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C017g08363</name>
        <name evidence="3" type="synonym">BQ5605_C009g05578</name>
        <name evidence="4" type="synonym">BQ5605_C009g05581</name>
        <name evidence="2" type="synonym">BQ5605_C017g08476</name>
        <name evidence="3" type="ORF">BQ5605_C009G05578</name>
        <name evidence="4" type="ORF">BQ5605_C009G05581</name>
        <name evidence="1" type="ORF">BQ5605_C017G08363</name>
        <name evidence="2" type="ORF">BQ5605_C017G08476</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY19876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY20118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY82557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY82597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NYR8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY19876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY20118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY82557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY82597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="76" mass="8862" checksum="9B61F80147395E94" modified="2018-09-12" version="1">MESLPCLHIHTRWSVGSVLKYTAVATTFEERVDSDRPQLVVIFTELGDLDVPFIRYIGGSRRTHNLLWIWTWSTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P0Y7</accession>
    <name>A0A2X0P0Y7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">BQ5605_C002g01068 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">BQ5605_C002g01068</name>
        <name evidence="15" type="ORF">BQ5605_C002G01068</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY29591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0P0Y7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015918">
        <property type="term" value="P:sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000029">
        <property type="entry name" value="Putative Patched sphingolipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053956">
        <property type="entry name" value="NPC1_MLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032190">
        <property type="entry name" value="NPC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727:SF2">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22314">
        <property type="entry name" value="NPC1_MLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16414">
        <property type="entry name" value="NPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016006442" evidence="13">
        <location>
            <begin position="24"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="772"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="796"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="855"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="886"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="968"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="993"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1335"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1360"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1387"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1474"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="14">
        <location>
            <begin position="846"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="374"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="469"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SGY29591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1527" mass="166657" checksum="CE464537AB58A424" modified="2018-09-12" version="1">MIPPLLPLQALTFLSLLVPTTYAFEQHDPANPQRSSRSSMTLTSTLVKREPGRCAMRSSCGKKGVFGGSLPCPFDGEAQENSDPTYLAVLAQVCGEAFPKKTCCDLEQLQTLQSSLAQAEPLLATCPACRNNFRHFYCSFTCSPDQSLFVKVTETQKLKSPDGEEKDAVKSVDFDVAERFGKGFYDSCKDVKFGATNGYAMQFLGGGAKDYLAFLRYMGQERALGSPFQINFPNHSSSPSLLLDNSPIQSLDNSTAVPFDDSPLSCSSSDINARCACPDCPSTCAILPPLQSPAERYAHRCRVGKMSCFAFSLTILYAVGLVSFFVLVALKDVLWSRQSYLKSITTNDDDGLDQGAWTRLRNRFSFTEWTSRPDTNDYDRVPMEDPLTGDYEESPRVLGGVSPLPGSTSSTGQSSSGNNSLVGATSTQNAAERETGRGRPPSGGTISSNLSTSSSYPRNRSSVGASLLDPNSDSTNPFLQPRTYKLNTILSQRFYRLGLFCAKSPYLTLSIGLILCGLINIGWDKFEVEKDPVRLWVPHGSTTERQKELFEYDFGPFYRTEQIFISRAPTNLAVEEVQLMKWRAVDEPVLNWEVLQWWAGVEKEIRGLQSERDNATLADVCFSPATEPERPVDASLCVTQSFMGYLADSLQGVSEETWANTLNQCATTPAACLPASGQPINPKLVYGKIPDGEAGAIVRADQARALVVTYVVRNSLDKEIIAKAQSWEAKLLTYLHDLARHDGEAARLGLELAFSTESSLEEELNASTNTDVPIVVLSYVFMFLYVAINLGSSGAGILKVVGRTLLFLVASFVQVFRRAVSSDRRRTEALELSVSGSTLGLGDYIRRQVLVDSKFLLGLWGIIIVLVSVSTSVALCSALGVKVTLVIAEVIPFLVLAIGVDNVFILSHELDQQNQRAYAAASRHGPLFGGDSLGRGENDDLGIDDDPEGLPSAEERVARAVGRMGPSILLSASCETVAFALGALVGMPAVRNFAIYSAVAVLVNAVLQMTVFVSAMAIDLRRVESNRIDCFPCVKLAPASSFDLGSTVSEGFLARFIRTVYAPILLFKPVKYFVVSLFGGLFVLSWIGARHVTLGLDQRLALPGSSYLVDYFNAVDSFLDVGPPVYFVAQNLNFSSLDTVKSICGRFSTCQELSFANILEAERKRPDSSFVAEPPAVWIDDFFQWLNPLLEDCCRVKISDPNVFCGPNDSEFQCRPCFEDREPGWNITLDGLPEGDEFMRLLEHWLESPTDESCPLGGKAAYSSALKIQDHSVKTSHFRTYHTPLKTQDDFINAYASAQRISAELSKKTGAEVFPYSVFYVFFASYAHLWSTARVVLSISLLAIFLVTALLLGSLRTASVVLLTVFLSCVNVLGLMGAWHISLNPISLVNLVISLGIAVEFCSHIARAFMGANGGGLPYHHVQGEKDRNDRSITALIDVGTSVIEGITLTKLIGISVLASTKSQLLETYFAKMWFGLILVGAVNGLVFLPVALSFWGGQGQFCSLLFEHSDFMGGGGYYNTDAGVTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P138</accession>
    <name>A0A2X0P138_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C002g01138 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C002g01138</name>
        <name evidence="7" type="ORF">BQ5605_C002G01138</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM170 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY30283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P138"/>
    <dbReference type="STRING" id="796604.A0A2X0P138"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019334">
        <property type="entry name" value="TMEM170A/B/YPR153W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22779">
        <property type="entry name" value="SD17342P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22779:SF6">
        <property type="entry name" value="SD17342P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10190">
        <property type="entry name" value="Tmemb_170"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY30283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="147" mass="16634" checksum="08B42589D4400EAC" modified="2018-09-12" version="1">MDLIRDDDENNSISANPPEGYVEPGWPALYSALHQDPQYLYQPYAIWRFTLYWTLLFYGFVFLVTGLLLLLNFTKRHPRLALLSFALWILSSLLLGLISSTIVAYALAALYNAAFLRMSTWVPPLWGAVQVLLLIFSAAANVPFFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P3R8</accession>
    <name>A0A2X0P3R8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g02250 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g02250</name>
        <name evidence="2" type="ORF">BQ5605_C003G02250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P3R8"/>
    <dbReference type="STRING" id="796604.A0A2X0P3R8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635:SF196">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="113"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY39634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="518" mass="57617" checksum="8B0B72ACDD13C76B" modified="2018-09-12" version="1">MLGAASDYFERVYEDRPIDDAALKAIIDGLASTRLSPADSLKLEEAYPLEEMTKAQAACKSNSSPGPDGLPVEFYRATWPATGPILRDVINSIPTEARQPGPLPRNTAHIHLIHKRGERDQLSNKRPISLINADERIISQAHNQRLAPLLESLIGPTQRGFVPNRWIGTNIAEVQCLMDPGLPGSTPVSGMLAVMDFEKAYDRLSHPYLDAVLCAVGLGPKARQWYRATYTNQSASIFLNGWLSATFDILSGVRQGDPLAPSLFVLAIEGFARQIRLRVKGIDIAGLQNVRELLFADDACCALHNLSDLDHLNRAIELYERASASKLSNVKSFLYPLGAFRDRSIAPDLGTWRLSDSQFRYLGIQVGVEIAEDAGWEDVKALTIARIRSIPMYDLPYAAKCSIINIYCYTKILYYSRFLPAPKSVVKEIEEAAMLAIHGRASDGTQRRPKVSRSRLCTPLDHGGFGLIDLPRRLAIDHAKWVFQLRAPDGCFTRHLFDIRIRLQAPNEPTPFTFGTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P436</accession>
    <name>A0A2X0P436_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C004g02691 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C004g02691</name>
        <name evidence="4" type="ORF">BQ5605_C004G02691</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY66629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P436"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retroviral polymerase SH3-like" evidence="3">
        <location>
            <begin position="163"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="426"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="968"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY66629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="999" mass="110752" checksum="358E8632A2B60173" modified="2018-09-12" version="1">MSLTDLPAADVNTMAGPDDRASTPPPSSTSTQSQNIDVSAIGSITLTREQYEELVRYQRTRDEEAPTPRHLLPPEAPAAFPEDSKLKGDNYVDWDITMSLTVDREVCAYLRRGTFCRPEARRTCVCFSHTKNLSSHAALKGGVPNHRWSGTAPLMTALRAFGCRAWATVPGHRRDKLDPKGIPLVFVGYDRHAKAYRLLDPTSMRVSLSRDVKFVETEFPFLSMPKRATAPSIRGYRPIAQPMLQPEGPRATPNQLPPPNDELPPPNDELPAPDHEAASVRSDATDAAEVLPPPEQVPEPPAKVKPAWEYGDLARVGPDPGKYGEVDPRNIIEGPRTRRRLVPTMIAKEQLDSGPDGPTDAFKNLILAFAATTEGFAEHDLAMVHDPSKWGDVIRTGQEEVWHPPARDEFDSLLNDYEVFEIIESCDLPSGEILLRSGWVFRTKRNQHGDITDHKARLVAHGCSQRPGLDFEKNYAPVVKFTSIRALIALAAANGYHVHQADVNKAYLHGKLDKPLYMRVPQGIDLPGKILKLSKSIYGLRQAGTIWNAEIDSTLRSLGYIPTKSDICIYRRDHNGHSHYIALYVDDLLLVGPSVAEIDRVLDALELMYGIKRLGPAEYILGIQVKRGQDGSITLSQERYLRDLLDKFRLGNAKPASIPMQPGVVLDFQDSSATPQDRTRYLQAIGSLMYAAVGTRPDLAYVVAYLARFSQQPSPAHWTAITQVLRYIKGTLDLGLTYRKTDVAFHGYSDANWGACLTTSRSTMGYAFIYSGAAIAWCSKREHRVAKSTTDAEYLSLSYTSGDAIHLSELLAELGHPVPGPVVIYGDNQGSLALARHPTNHQGSRHVRISEHYVRERVAEKEIDVVYIATADMFADIFTKALGPKPFLFHRENLGLRGAVLLARNGRTWVDFHGVPYPGWRHQDLDTGELGDIRIMPLTAMTPDRSPKFYPGSRGRDHYAAMSVHHFDGSWRDNRPSGKAPESQGAKGPGQPPSKSTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P4K9</accession>
    <name>A0A2X0P4K9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g02570 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g02570</name>
        <name evidence="2" type="ORF">BQ5605_C003G02570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY41835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P4K9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY41835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="85" mass="9620" checksum="3A1297644253F3C6" modified="2018-09-12" version="1">MGEIDIECVLKKKERVNETRALDSIRVQATSESNQYATPPSASIRRRATRAPTSQCHKSFWTADPLLISHNRVHAVVGYVCDDHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P500</accession>
    <name>A0A2X0P500_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C001g00135 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C001g00135</name>
        <name evidence="5" type="ORF">BQ5605_C001G00135</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY44264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P500"/>
    <dbReference type="STRING" id="796604.A0A2X0P500"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17394">
        <property type="entry name" value="MFS_FucP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
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    </dbReference>
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        <property type="entry name" value="PROTEIN TSGA"/>
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        <property type="entry name" value="MFS_1"/>
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        <property type="entry name" value="MFS general substrate transporter"/>
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    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="62"/>
            <end position="83"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="90"/>
            <end position="108"/>
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    <feature type="transmembrane region" description="Helical" evidence="4">
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    <feature type="transmembrane region" description="Helical" evidence="4">
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            <begin position="156"/>
            <end position="175"/>
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    <feature type="transmembrane region" description="Helical" evidence="4">
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    <feature type="transmembrane region" description="Helical" evidence="4">
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            <end position="263"/>
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            <end position="292"/>
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            <begin position="299"/>
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        <location>
            <begin position="328"/>
            <end position="349"/>
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        <location>
            <begin position="361"/>
            <end position="378"/>
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        <location>
            <begin position="390"/>
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        <location>
            <begin position="425"/>
            <end position="446"/>
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        <location>
            <begin position="433"/>
            <end position="446"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="EMBL" id="SGY44264.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="446" mass="48681" checksum="78084FB66D136794" modified="2018-09-12" version="1">MAGGGAVTGVKATGNVTKRQEYFAFGLVTSLFFLWGFSYGLLDVLNKHFQTFFGITKLQSTLLQVAYFGAYVVYSPVCGQFISKFGYKKGIYMGLSLYCIGALGFWPSAKFEKYGGFVASAFVIACGLATLEVCANSYVTVLGSPEQAAFRLNFSQSFNGLASFVGPLIASKYFFGDEATQHSLGNVQWVYLAVACLGAAVMVLFFFATLPEISEDDMNAQQAAAGYVDDRPLYKRRHTVFGFVAQWMYVGGQVTLATFVLNYLTDKHDFTTARASQLFSFMQITFMVGRFASTPLLRFFNPATILAVYGAMCSIFTLVAALKGGKVGLASLFIVFFFESVCYPTTFTLATSNLGKWTKRGGSLVIMGVGGGAMFPPVQGAMADKTGSQLSYLIPFIGFLFVFAYGLGMRWYALKFEQKQLNTEAGPPTLTRTESDKASAEEVEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P5M3</accession>
    <name>A0A2X0P5M3_9BASI</name>
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        <submittedName>
            <fullName evidence="7">BQ5605_C001g00236 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C001g00236</name>
        <name evidence="7" type="ORF">BQ5605_C001G00236</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY45028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:nucleus"/>
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        <property type="term" value="F:5'-3' exonuclease activity"/>
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    </dbReference>
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        <property type="term" value="F:5'-flap endonuclease activity"/>
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    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:DNA damage response"/>
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        <property type="entry name" value="PIN-like_dom_sf"/>
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        <property type="entry name" value="XPG/Rad2"/>
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        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
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        <property type="entry name" value="FLAP ENDONUCLEASE 1"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
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            <dbReference type="SMART" id="SM00485"/>
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    </evidence>
    <sequence length="691" mass="75962" checksum="5F32CA7923052BD9" modified="2018-09-12" version="1">MSDETNDVAAGAFTCKDCAQPGLASKMGIKDLATTLTKHAPQAITPLRSLSHLQGQTVAIDASVLTGKLHFSRPTQAHPSQSSPSTSDANTISRTRIVQGWYTFLRALSKAGIKPIVVFDGPTRLAAKANENRRRLEARELQKGRSGVEWNRGERLRETLEGWRRVGERDWQEIRKRFRETVLKGVEDGRVVVTEQAAWVSDSASDPLSTGTLEPPRPTAEPLSTLPITPPPPPPPPLWETVQAEAEKTVVDAQEDVVELPQEDDVEFEEEEESSSVSDSAASDPLSTGTLESAAHPISDHPSTLLRTPPPPLPDAVLTTVLSLAELHARFQADATNTLYSKNQTLVTEAERRWYDSILAEERSSEDVNVVDSEILPHRLTGIDIDVLESILRQSNELERSHRTRAEAVPWQASEDVLDLIRSLGIPYLKPSPTSPYEAEALCASLYHARIASLVISEDTDVIVYQAPLLRRVNSAGQNPANTDGNGEVASSKGMSVWDAEKAREGLGLSREEMIDFALLCGSDFTERIPQKYGSIEAILNSQTRYLPSDPPIYLLSVAAARQIFNDIPPLTSEDHLTLIGRDATLDAMLDDGENEVLQKWGIKGGVLRFDGMGWPTVEEVNDRQAEGEGEWLLWEEDGEVVASEEGDWEVDEAEVEVDGDVGEEVPVVGQDQEEVMARMVDEIEIDDESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P7R3</accession>
    <name>A0A2X0P7R3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C008g05094 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C008g05094</name>
        <name evidence="3" type="ORF">BQ5605_C008G05094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA/RNA_pol_sf"/>
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        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
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    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="1252"/>
            <end position="1537"/>
        </location>
    </feature>
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            <begin position="1"/>
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        </location>
    </feature>
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    </feature>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
    </feature>
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        </location>
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        <location>
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        </location>
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    </feature>
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        <location>
            <begin position="1850"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY79283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2075" mass="231343" checksum="710DF9E3055EF1A2" modified="2018-09-12" version="1">METGDTGPPPGAPPPPSASAATSVPIGTKETQVPIATATYATAAIQKTKQTPEQQTQQQHRAKALTQMFEVMGAVPGNRTDRWLQATFATDEYPVATATSLKYSALNANRSIRNIFDFALDVTLTVQGASKASPADKADLLGCVTRLLSPQSPLCFDAEVTLPEHLAAFAPQIRGIQHSSFVRAGVVNHRISVGFVSAKARDSALTAPLALTWHSAKAHFAKAHHFYHNMVELRINVGVAAVPSRDAIVDSFKSIVTKITAKGHRCELVQVLRVIHVDNDSAYAHLAGEFSAFIRFNDDALFKAPNNTLKELLPSKVSLATRGNMHTAVRHDYEREAACARCHFVGHVETCALEQERRQKEANKNTGRHNKHHNNPTNTTTNNNDTTNTNNTDNDASEVVAPSRALGTDQLESRNRFAGLEVEGGQEDDIEEEVAGKEGEEKEQVEEGDEDTGAKADDEDSDSDGNAGAGIDKAGGDGKDDDKDDDEDDDKDEQDDSSEGSERRGDDVMKDGAEEEDEGMETEVEEEVEQEQGVQDDSIMIIDDGQTTITTVSRESTPRSPSWPPLSPETLAKSLREGAAWDRANAEAAARVQAENEAIINAQLDAEEPLVRHQFAEWGQEDGQLRFINIRGTGSRSNKKMKRSQTVADLSDPSDGPVDVKRVLNRVKGRAGKEVAGQGKRVTRSMSAAAAMQVEGAKAKAEKGKGVEEEKRWSDHEPEDDILPEFPLFEDDTTAKSTWNVRRCMGIPEKRRDIYTYLSTFKASATLLQEHFIKPELWQCIKNEYEGKAFISKHCLTLIPADSPMIDAEILRTHSALDGRILVTSFRLRGDIRILEINNLYAPVDTKQRLTFFDKLHFHRTQSTHLRLLGGDLNDCPLPAIDRRNQGRHGHHWPILIGKLDSPYTDCIRFKHPLTPSFTRPNIVRKRPKSFSRLDYFLLQRTHQKRLFQASTIYDHPKDLSDHRPVSIVLVLSDERRDAAQPNNSLPTTSNQLHRINAATFKTAGFQGMLEGWLEGASGEEPVGELEVVLGNCEKEGRELARREHRERVERMAVLVGRVQDLEALPVMGDEETAEWTRTTEELRRAVNERARQLRIRAHVPEIATEERLSRPVHAKLAARSSDSKTTALRLPNGELTHDIDVALDHTQAHFQRLYNLEPRDRDHVERLRDDFLAPIRAARTCDDPSSDPLFLRRLSEAHIELLQQPITEDEVVAAIATTHPGRSPGPSGVPYELYHTAPRAWAKALSRAFNAMTERGSLSPKQGQGLVRLLFKHHKIGADRAELSSYRPITLRECDYKLFTKVYVARLNHVLPDLLPPQQHGFVKGRRSADASFHLRLLIEELGARGTEFPDAALLSLDQSSAYDLVEHEWIFAIFDALGAPAAFQRVLRMLYSGDSTTARYIINGFLTPPVRLTCGLGQGDPASSSVWDVVFQPFLDALHRRGIALNLSLPTIHPYPQSRAITSLAFADDVVVAVADSESLTLLDDLALDWRLATNGRLNTDKTVVLPIGCRWEAGDRPLVVKAEGESLEWIGLSFDPTGNTELANVNLVARLEAVLDSARDRGLTHHTRAFYVNRYAIPKILHILSADIPPLEVVKELDRILVDFVRGGKRRSCYGKDVVFTPRFKGGLGVMRMQDVVDSVAARVWDVLLGGSDAIWQGLARAAIVRAHPAPDFDLATDAWPCDYTPIRTDLHPRWQAVLKVPSTHNAQVKPRTLTLANLLALPIKLHTLHYLPGAPAVSRSPYDADYAAFAIYAKVADLFRRELYPGGGFHLWTPPTDVVVSNSEYDQRGRPQREHIVAWYRHAINRLRFTPIAQPVAAVRINGPPRVRPRPEVRPTTPLESILPHPIDPPQRLPRPALPDQSIQYNLLSMDRPYTIRRIRRVLNAKAFTDTIGFRDSLQPDDIKGFWKGVNSKALTAREREVWFKLIRNFTPTRSLQFHQKHDDSPACLVCGAPKDDREHYFFDCVDSGNVWIAARSVLCDALGLDTIDNTHYTAVQRMFGLPKLKASLRDQEGAGRTIEIFTGLVLEMISSGRWGMQKWGTRTEGVGRRRIILEERLKLRAGGAWGRRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P8E4</accession>
    <name>A0A2X0P8E4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C006g04111 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C006g04111</name>
        <name evidence="8" type="ORF">BQ5605_C006G04111</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNAPC3/SRD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY56159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P8E4"/>
    <dbReference type="STRING" id="796604.A0A2X0P8E4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003681">
        <property type="term" value="F:bent DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001046">
        <property type="term" value="F:core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022042">
        <property type="entry name" value="snRNA-activating_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13421">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13421:SF16">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12251">
        <property type="entry name" value="SNAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="308"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY56159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="565" mass="62451" checksum="29DC7C18AA4BAE36" modified="2018-09-12" version="1">MPSFDLLGPPTEATIDLSSFTRQAVQSLQTARLRQAEARSYIEKRTSSTVGGDIDVESDAQEQLRKRCSVQDLTAHTSAMYSDDYMRTCLRTFLETTWLDPHNDADLRHLNLKSKSSLRDKLDRIKRSHVAIVNAVETSQSSSSTGLTSAGSRGNASSTDDMTVNTIADDVASTNPAADPRWSKWLREHDDNTLRIAKPTVHPVFLRAPGHADLQTLTNLRPGKSVPRQSRPQSSSQGTNATGSSSTATPLLSSLMYTITFQPIAPTLQPSSAKAITRAQTLRVLGTTTLAELKTNIICSANAVPGVEMSGDEDATSSPMGWDQDEDHEEGEQGEENSDEEERGAAVMSRKQRNPRTVRELDLALMLEPTEAARLIKWGKKRRKTGSVFGIESVLFADQSREVEDYASLIKQAISEIDWSTQKSANGATQPSIPTWSIGGRIDDIVLGSLKLRVGEPYYYLHDGSAEHTWTIDEIRLVHTLDPSPTASVYPITSFLSRNKSLSRCYICDIDTATVITIDDELAGRSPALMCEKCFQLLHSVDQNKDHDDQDGHRKWRRIECVTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PBR7</accession>
    <name>A0A2X0PBR7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C004g03005 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C004g03005</name>
        <name evidence="10" type="ORF">BQ5605_C004G03005</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY69384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PBR7"/>
    <dbReference type="STRING" id="796604.A0A2X0PBR7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030258">
        <property type="term" value="P:lipid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF4">
        <property type="entry name" value="LYSOPHOSPHOLIPID ACYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="416"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="518"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="416"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY69384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="587" mass="65842" checksum="3AED262433E33D29" modified="2018-09-12" version="1">MKWLDDQFDQFAALVGVSGDQIKLITLVVAAVPLSLVFPHLPSSTVSVLPHLYAALPSVVYLCFVLHLRRGFLELVLSSLVAWTIVKVAVATKRKDRLAPWLVFVVVMGHLAINHVIRHFEKTGPETIEITASQMVLCMKLISFAWSVHDGQQPIEELDATQRASRIVEVPGLIPFLGYALFFPSILAGPSFTFASYTAWTSHALYLKETGLREGAASSTTRSRDLIADGRRRKAAKRFITGVVYLGIFSKYSYTYDYQRMLEPTLRVLPLWKRVGFMQVAGFVARTKYYGVWCIAESAFIISGLGYNPRTKHYDASRNVRIRSIEFAPNFKILLDSWNMNTNVWLRECIYKRVTSKGRKPGFVSTQITFITSALWHGVNPCYLMTFVLGGLLQSTGRSMRSLVRPFFLPPGAVTLSRSSAPSRNTSTASVDTTTPPVTEPEKPAPPKLAAPPQTPLKWMYDIAGIIMTQLSLNFAVAPFMLLTVHGSFAVWHSVRYYGILIVLIPTIALRLGLAKTLKQKLKARNAAAEKMNDAEEKKRLEWEREVERKRMRRGVGVASLAPDVEELLLEEEREEARLAKDSTKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PCE6</accession>
    <name>A0A2X0PCE6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C030g10850 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C030g10850</name>
        <name evidence="1" type="ORF">BQ5605_C030G10850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000069">
        <property type="protein sequence ID" value="SGZ09181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PCE6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ09181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="48" mass="5330" checksum="0D9916FFA41B2700" modified="2018-09-12" version="1">MTPVVRNLDLCPAHQHSTKVVKFPFVYVVQHDTPQSLDGPLGVRAAPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PDL6</accession>
    <name>A0A2X0PDL6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C008g05019 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C008g05019</name>
        <name evidence="10" type="ORF">BQ5605_C008G05019</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PDL6"/>
    <dbReference type="STRING" id="796604.A0A2X0PDL6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000017">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF12">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="388"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="462"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="506"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="549"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="90"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY79034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="615" mass="67172" checksum="D5D819D6FC6755F3" modified="2018-09-12" version="1">MSATLDKHAFEKSSDKEPSDNDVHVTTAAAPEIYDPSQESIWTRAGLSFRSYTRAPGSTAGLKVHGSAAHIDPLKEGANPMLQQKMKPRHLTMIAVGGSIGTGLFMQVFQAPSPEPMRGRHTIALRNGGPAGILIAWSLIGIMMINVTQCLGELAILYPISGGFYTLAVRFLDPGFGMALGYNYLFQWAVVLPLEITAAGITVQYWNESVPIAAWITIFWFAIIFVNIFGTLGFAEEEFWSSCLKLTVVVIFVIIGIVLNVGAGPSGGEYTTYLGGDLWRSPGAFANGFKGRGYLAGVCAVFVTAAFSFAGTELVGLAATETPNPRQTMPGAVKGTFWRITVIYLSSLLIIGLNIPYNDERLLGGSGAGTSPFVIMVDRAGIRGLNHLINATICISVLSIGLSCVYAGSRVLTALAETGYAPRVFAYVDRSGRPLWSVLFVLAFGPIAYVNVSGSGDVIFEWLLALSGLSTLFTWGSICLCHIRFRRAWKVQGHSVEELPFKAAGGVYGSWFGLILVILVLIAQFYVAIWPIGGRESDPKAAAETFFKVYLAMPVLLFFWVAAFLWKRTLPQRAHDIDLDTGRKSWLTVEEMRLYREDRRNAPFFTRAFRILFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PE97</accession>
    <name>A0A2X0PE97_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C008g05279 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C008g05279</name>
        <name evidence="3" type="ORF">BQ5605_C008G05279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY80000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PE97"/>
    <dbReference type="STRING" id="796604.A0A2X0PE97"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018829">
        <property type="entry name" value="DUF2433"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052743">
        <property type="entry name" value="Glutaminase_GtaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF11">
        <property type="entry name" value="DUF2433 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987">
        <property type="entry name" value="GLUTAMINASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10360">
        <property type="entry name" value="DUF2433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2433" evidence="2">
        <location>
            <begin position="349"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="476"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="517"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="611"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="656"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="687"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="715"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="736"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="761"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="805"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY80000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="841" mass="85824" checksum="0B665EDB04E00A36" modified="2018-09-12" version="1">MLLWWGPTAQRIPVVICGAVPAHQSVDCPFMVAPKAALVRRTHRPYTLNNHSHIKLLADKTISSRASSGALSTLNKFAAEHSAVAIIHSGDFGFYEPSSLPSISDRTLRHLVQYSSLISPAFRSALLAPNVQPAQMREMLASPPLKLPGGAPGPTVDDPSYFGLSDFPKLLAGEIKLRVPVYTVWGACEDVAVLEKIRIAAPSFLNVPASAEELQAATGAGEGPAGRSNLTTTYGYSIPNLTVLDEATTRVLLIGGVRLRLFGLGGAVVSHKLFDNGTGNATIAGGGGTMWTTVLQVGELVDTAQKVYDATETRLLVSHASPGREGLLAQLALVLKADLTVSAGLHFRYGVSYNEFSVQHDPEAYKLKLEYAKKDFNEIWDTVKSQVESVVDQNQRVLLNNALAVANRVPSSGAPSGPAGAAGTTNATEETAWKNCWNWNLPDAAYGSLLLDIVDGRIGSEMRSQGFNFAYRQNKPAPSAPAAAAPESSGAQISSTQNASTTAPKSAETKVETTSVPAQAPLTAPSAPAASTNPNVAPPTDPSPGGPGAHRGGRGGYGERGGRGGFGPNGRTASGRGGAVVGRSNGSWSSGGERTGPEGGFRGERKERNETAAASNGSNNTNESKVPASGVAKDGDRAADKKIEATSATAGKEEGASSTPTTPSASGGGRGGHNGRSERGGRHSRGGQAGHKSGGGGQHSSSSGNGAKEKESNNESSTAAPATPVASGAASGGGEASSSESAAAGAPTTGTSGHGERGGRGGRGAGRGRGGGRGGRGGGNHHQTASGGVERGEGWNSSLVPEGGRANRKENNNNDEGGKSKSAGEGWSAPSDAQEGGQGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PEI0</accession>
    <name>A0A2X0PEI0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C008g05178 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C008g05178</name>
        <name evidence="1" type="ORF">BQ5605_C008G05178</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PEI0"/>
    <dbReference type="STRING" id="796604.A0A2X0PEI0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY79626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="108" mass="11412" checksum="8BDC06D4DBC0699F" modified="2018-09-12" version="1">MGIGSVMVQSRGRGRAQTRCPRHFAIDPGSVLSYHKVENNPGQVKGHSAWGECRLEDAFCAGGGWLSNGTLVSIGGNGVQSSNTFSQNSVNAIRIFTPCQVDGSCDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PGM7</accession>
    <name>A0A2X0PGM7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C035g11372 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C035g11372</name>
        <name evidence="9" type="ORF">BQ5605_C035G11372</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000064">
        <property type="protein sequence ID" value="SGY96973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PGM7"/>
    <dbReference type="STRING" id="796604.A0A2X0PGM7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF495">
        <property type="entry name" value="HELICASE SENATAXIN ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="7">
        <location>
            <begin position="700"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="8">
        <location>
            <begin position="959"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="57"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="222"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="278"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="503"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY96973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1222" mass="134621" checksum="06EDD097989A109A" modified="2018-09-12" version="1">MSSSSRWGRSLIHQAYHPQSHQVSSSALGRGGRDSGQSASASTIPFVRAIHTSSTSAAVEGVLPKRNGERNGPPPIAPLPTPPPRTSSFSKLKARTIPTRSQSHVKDVSHIGGAHADDPVGEMYYEMDVSDAVDEIPYDDLVSALYATRKTPLADEQDLGEEGVQGIEGLFEDVEGDSRKRAEESLDWQVLLDELATRDHREGSKVGTTKAKAREIEEPKIVPAPKPTTTTTITSSSMEIKPSKSSTSQIPVPVSTPIPASTRAPMVKAIPAIITPTKRLPPLGKARDLNPSPRPIGILPYTPPSDVSPTDPSSRPLLSRYDWRLSSPLPRPSPSLIPPPLDIPTSNLQQGANKLVGVGQAPYFSGRRIKDVEGWGWKGRVPQGEKGTWRAADRHRIKLDRLLDLTEEAEEKSYLATLARSGTPEQRETSGRTVCRAQGMWLTKSKRTDEILKMTREEKDELRRKSAGGGGVISTWRNCEGGDLDEANGYKFVPGTILRFTPLKPEDVGSGPVPPPSHASKHPQGSVLEVQNGRLIVIFEEADMWVLGQEEYRIDIGVDDASYHLQRAAIDSLYFDSARQRLRNERTWQAAHMAFARTKLCPTVREWTLQGTDVRELIVPAEATPAVEVVQNSADFPFDELIDGPDESVTASMTQVEETTPTPASNPSPLLCDNQLINSWVKRHQRCPPLAMEGDPILRLNDSQTRAVAMAMSESLSLIQGPPGTGKSATLVTLVHLLKTHFRIPQPILLCAPTHVSIDHLLSLLIDAGLNPLRMGKAHKVREELREWTVERRREGHPLWELCEGARVGCERIREELGGLRETVGDDKKGLERIMEIEEILKNEWRRFVTLEQRLYSSLLATADVFCSTTIGAGATKIMSMTDFPIVFLDEAAMCTEVSDRTGGMSCAQPASLFESRLDSQPVSLIPLMKGAQHVCLIGDQKQLPAVVKSREAVQNRLHVSLFERLMAEKAVQTTLLDTQYRMRPQISAFPNQAFYNSALKDAPNVLRRSSPPKSTYLQMNAETGEPDPCVFISHEGAETFFRQSTLNETEVDLIVSIVGDLLTRNPELDASTIGIISPYASQTRLLSDTFSIGDRRGFSSRVIDRWGFDIALRASQVEVNTVDGYQGREKSIIILSTVRSNAANFIGFLSDRRRLNVALTRAKDLLFVAGNERTLGFARSGWGGREEDDGDGGTGVWKAFLAWYRARGWIKQWGASGGKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PI39</accession>
    <name>A0A2X0PI39_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C033g11232 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C033g11232</name>
        <name evidence="6" type="ORF">BQ5605_C033G11232</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VAM6/VPS39 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000066">
        <property type="protein sequence ID" value="SGZ02869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PI39"/>
    <dbReference type="STRING" id="796604.A0A2X0PI39"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019452">
        <property type="entry name" value="VPS39/TGF_beta_rcpt-assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019453">
        <property type="entry name" value="VPS39/TGFA1_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF49">
        <property type="entry name" value="VAM6_VPS39-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10366">
        <property type="entry name" value="Vps39_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10367">
        <property type="entry name" value="zf-Vps39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CNH" evidence="5">
        <location>
            <begin position="17"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="210"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="605"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="605"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="662"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGZ02869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1184" mass="130397" checksum="0F6261C05683B12E" modified="2018-09-12" version="1">MHSPFSIDELISSTELGTDAVTATIFHRDRIYLGTDKGSLLVFELVHASTSRAPPSTKLALKQPALAKRPIEQLVALDEIDAIACLAGGDLSIHSMSSLTLRSSFNQLTRATCSSIARTTSSTSVSTTKQNTNHIVLALACRRRLILLSWTGSGANAVVSNKEIALPHQVRGMSFTEDEGETGTSLKLVLGFSTGEFGITTVPKVKHSAEFGSESTERSKIRKSPPGIAAAPNSASGKLDQPVLGELFTPTLAGAVTKDAAPTLATAVSSTATEGGKFSALGSLGLGGLSLSALTTKKIDKNEVVLIPRKRRKIKSEASEGQSEEENRRRAEEDWLYGKEWGWDDQDEGEKGFGSKVLVVRDSKSRAAISLSRLESDRCPSPLLADLAQELDISSGQVPRTSLGSISYPSPVEETVVTPPFIISLLSNSTLSIHTTDTLRSVQTLDLPMQSNSLIVSNPGANKIQTSARLLTPSSSSSPPLFVLTTSSTGAATAGATAPIVSQTLWIVRSQSWIEQIEALGAQGLWSKAIQLFRLALPFSESASQQLSMETLKRLKLLRSWELFNEGRFGLAVDAFIKLEVSAVKVVGLYPERIAGRLVRNDAEKEEAFGGRKVEDARAMEEAKPTEEEAETKMLSGDAVDSSTTSSPSHHHFSLATRLRESTIGSSSATPSSPNSTIRSSSVDSARLGTNSSEEAQQKAFNVSVDELIRFLTDRRQQINKALSLLPPSRRLLSSRLRPQVTKEQLDDIPDRPVAQLSIEHLARLAQVVDTALFKSYLATKPVMVGPLCRIDNWCEVEEVEEALLEKKKYRELLDLYNGKSTHQKAVKLLRRIAEDEDDPDKKVEPTIRYVQKLGPGHLSTIFEASEWVFATHRAKGLEIFIADLEEVEALPRHEVMQHLEGVGEEACMRYLEHVVHELDERGAEFHEKLIEVYLRRVLEGGQGNVGDEEGYKKLLAFLEASKSYRADRMLGRLPVSDSTSVVAGTRNSSMTKKDEALALVRALLLGRLGRHEGALQIYVYQLFAPELAEEYCRRVVATEQDIFHILLRIYLRPRRNDQKIMFEPALELIKKNALYLDPIVVFDLLPPLISIGKLKIFLEKTLRRSVQVKNETLVLKGITKSFLEKEERDKVDLEERRVKINEGRVCPVCGKRLGKSVLAIFLPRGEVGHYQCREAFQQSRMDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PIK1</accession>
    <name>A0A2X0PIK1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C031g10930 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C031g10930</name>
        <name evidence="1" type="ORF">BQ5605_C031G10930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000068">
        <property type="protein sequence ID" value="SGZ06279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PIK1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046921">
        <property type="term" value="F:alpha-(1-&gt;6)-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13132">
        <property type="entry name" value="ALPHA- 1,6 -FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13132:SF29">
        <property type="entry name" value="ALPHA-(1,6)-FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ06279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="617" mass="69177" checksum="BEED0C56A6D2CFBB" modified="2018-09-12" version="1">MYELVEEGVRRSVDSGSGDDELTELTMQGIGSPYYASSKKSGLWSGSVRRLLVTVRRRMTGTVPVGSLMRDDELTELTMQGIGSPYYASSKKSGLWNWRVSWPGVANELLRRFGSFPSSQSCLFRFLQNWLESRTGEGPRFAAVPERRSRPKLFYGIVLGLTIALTVQTIRLSATNSSYRAGGASIPLEDMYPASITVRRPPPPVDSSTFAVNDPKDSHIAAWRLSDDASRLPPCGRFILTPFRAGGIGSNMLIMLRGAMFAKNFRIALLVDNSYGWGYGRLEYYFEPYTIDCVPLEDWYDEKKTIPLWNPGWRTANRIRFSIDDSTDLIDHELFYERESFELQRLQRALFNHTIRPSVLPPSYTLPRPLIPAFEEYAQLLPTLLKPVPAILDDVERVKAMMRIGGEHPTIAVQVRLGDKRKEYDRSTRFIRNTFRNLTAHLEVMHGLYDRMVGCSSSQANPCYPLSPTARRFSIEKQPRAILLTIEDDALEQMAYDAIAPPPFIFDRTPNVGLPSHYTFVQKSFDNLPLAIRVASARAVIRDLILAAKETEAAVITMASNLGRLVALFAGESEALLGPEAPAMPEGRAGGRICALDAPWFSTTFLDGIWSRVPPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PJJ2</accession>
    <name>A0A2X0PJJ2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C028g10467 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C028g10467</name>
        <name evidence="1" type="ORF">BQ5605_C028G10467</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000080">
        <property type="protein sequence ID" value="SGZ11940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PJJ2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ11940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="132" mass="14878" checksum="FB4BF599742D5434" modified="2018-09-12" version="1">MDSPLTVSLELFDIASNAARSAAIPVGRGPPFGPLLFPQGVLFQRYQPPDTFREYLDFSLRRSDDKGFRSTPPTIFNCSRLYFYLSPAEALAGHYIDILLRHIYYGPFSTGPYFSCSYGYRCLFRLGVGESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PKY5</accession>
    <name>A0A2X0PKY5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C023g09719 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C023g09719</name>
        <name evidence="1" type="ORF">BQ5605_C023G09719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ24367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PKY5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ24367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="398" mass="44648" checksum="D2D1EA9FC52DB2DD" modified="2018-09-12" version="1">MTTMQPTLALRHVYEPAPHVSIRDDLGPQTAVCTHCKARHWELGPPVFRVFGRLYHRLGALIPAVTQRPTFAQTWLIDPAEATDTRLGPDGADSRMQRSTLTKLESILRTGNRFVREFASAKACAGWDTAKEWILRLCLPPGRDRRTHNLPTSSTEMAMLICDSDTNMGDRGPQDRILQSSARSIRLRCLSGSHYSSPQGKMASTPTFLFAGFAKLGCQSPETESRLTMVSNRARYLRVSVLMTEAKRRTKTATMRMKTARKGTKRMVMANDEGQVKRSRWRVSRSPFFAHYLPNATSTSQSRIAPNVSSWRCDGVCCQRVKVSAADHDDVRPRLTGNQGCTGADSACNRPDLIARVFEAKSGNKRHAGCFGDECKMNRFCFFATVRLSCYFLNFILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PM38</accession>
    <name>A0A2X0PM38_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C026g10213</name>
        <name evidence="14" type="ORF">BQ5605_C026G10213</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ27883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000007">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="12">
        <location>
            <begin position="594"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="13">
        <location>
            <begin position="1136"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="11">
        <location>
            <begin position="1448"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="312"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGZ27883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1500" mass="168338" checksum="AB15AC543E6109AE" modified="2018-09-12" version="1">MPTPTAPSHSPTYKPNDPPQLHSTSMEALREYFMRLDFYNRRIARTPITSDYDKIEGAGMGLQVFALKTWFTQGLSKHLAKPYAQFKSELIRRAVPADFVWTQLAKLHRLRQAPGHNIDAFQEFSDQMRSLQMEIGFQVVSDQEVAKLVLLGTDPELCRILRTHMVSSRAGWSDLSLEKLALDAPVVPTSPEAAEVFSDAHTDQPLEFDYQVFERIGREEWSVIAQRRQAIATQVGALQQRPTYSRPAAASAAPHVATAATGHSPITGGPRPVTRLTVDERAYLDQNHGFYRCRTLNADHISRNCPRYLSPMGASATPSTPTSTAPAPRPGPRMVAAIRTFQETGDSTVFAGLSSDLEDDNDPSYAPHPFPPLPVSLAGAHGTLLASALVDSGSPQTFLSEELVQRLGLERRALEQHSKYTLAMQDQVPTVFTCTHFVRVPLELANGLWAAGPTYVEVVPLGKDLAIILGGNFIYRHKMELGLFPQPHLTCKANPIHAIDLLALSSQPCAAARVAAIAPVSDNKEQLRLAALDHRLRAEFADRFPADIPPVHLYQSPVRHHIELDTPSTVVNLRGYPLPKKYCEAWYLLLQEHLAAGCLRPSRSAYSSPSFIIPKKGCDVDPTIAPRWVNDYRELNKHTIKDRTPLPLPDDILSTCSNAQFWAKIDMTNSFFQTKMAEEDIHKTAVSTPWGLYEWTVMPMGLCNAPATHQRRVNEALQGLLGTICFVYLDDITIFADTLEEHEARVRQVLDALRRAELYCSPTKTNLATAECLFLGHIINRTGVHADPKKIQRIEDWSLPKTVKELRGFLGLVQYLRKFIPGLAEHTAALTPLTRQGLSSIATLWIPNEVRHFKAIKAIVTSLDCLRPPDHSANAAPFWVMTDASNQGIGGVLLQGQEWKVARPIAYWSRQYIPAERNYPTHEQELLAIVEALKEWRIDLLGSHFHILTDHSTLEHFQTQRTVLSRRQARWLDTLAEFDYDLRYLPGEDNIVADAMSRYSFTDPLPTLVAAVSHVKLSDAVKQQILDAYKTDPFCQQAMSNIGSVTSDFKIVDALLYLRGRLIIPSLAPLRESILHDAHDAQGHLGDMKTYQTVQQAYFWPNMSRDVKHYVQQCDSCQRTKACTTHIAGKLHSLPVPTRPMADIAIDFVGPLPANKGFDRVLTITDRLSGYVRLLPARKADTAAEVAARFHEGWHRLFGLPQSIVSDRDKLFTSKFWTALHKRLNIKLQLSSAFHPETDGRSEKTNKTAFQILRALVNKEQSNWAECLAVCEYAINSSLNVATGETPFELVLGYTPSLAPLARVDGDDDLPSVEELLALRFQACEDARDQLAISKVRQAAQSNKKRQVEPSWAVGDLVLLDSSDRRKRLHTRKRRAAKLMDRFDGPYRIVKAQREISSYTLQLNGDDAAVPFFHTGKLKTYRKNDTALFPNREPARLGPVDVGGKPEYIIEDIVDERIRAGKQQYLVSWLSWPSDSNSWEPAEALEDTEALDRWERRNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PMG2</accession>
    <name>A0A2X0PMG2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C025g09981 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C025g09981</name>
        <name evidence="2" type="ORF">BQ5605_C025G09981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000087">
        <property type="protein sequence ID" value="SGZ26874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PMG2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016018286" evidence="1">
        <location>
            <begin position="19"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ26874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="230" mass="24514" checksum="E0E5111920ECF49E" modified="2018-09-12" version="1">MLAAQLLTLLAVSMPALALSGLEQRSLQLDASAHLALARARAAKRATATASDLAKRAFDVAYTAIGLTRRDFADHSALSKRSQPRIRCRLGREIILIFLTATVKCNQVCEVTCNDGYTAQRSDRATACIKNVDKCRNKTCAQDSNGVSSCNDGECSLECTTRGYSLSKASTACIAFGSDANNCGAEGNKCKASYDGRFVATCENGKCSLDCPSGFKAGTNKRKQSTCVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PNG1</accession>
    <name>A0A2X0PNG1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C027g10391 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">BQ5605_C027g10393 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C027g10393</name>
        <name evidence="2" type="synonym">BQ5605_C027g10391</name>
        <name evidence="2" type="ORF">BQ5605_C027G10391</name>
        <name evidence="3" type="ORF">BQ5605_C027G10393</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PNG1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036058024" evidence="1">
        <location>
            <begin position="24"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ28626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ28639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="78" mass="8233" checksum="03610CA77E5E985F" modified="2018-09-12" version="1">MLMLSSAVASVLAVVSLTSVADAAAIHAPQGRSIQRRQKITTCRGTGQYPLPQNKACKPCSWKFPGASTCTATAALRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PP48</accession>
    <name>A0A2X0PP48_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C052g12569 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C052g12569</name>
        <name evidence="2" type="ORF">BQ5605_C052G12569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000099">
        <property type="protein sequence ID" value="SGZ29932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PP48"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ29932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="158" mass="17553" checksum="4B80BC2B572DCE02" modified="2018-09-12" version="1">MTLSPLDSGKSYGQAPRASSWNNALFNTPQGQRAEEYLAKNKVTTIWDLKPGKKEISIADPDYDFHLQRKPISRYTKASAASRNEPRGDRLNKGTQLHQRPRGNGHQADRITSAMEKIQQSQALLADSTAQPITITGRMGSRPYDRTPPALRPAAPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PQ43</accession>
    <name>A0A2X0PQ43_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C043g12108 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C043g12108</name>
        <name evidence="8" type="ORF">BQ5605_C043G12108</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000117">
        <property type="protein sequence ID" value="SGZ32188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0PQ43"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061245">
        <property type="term" value="P:establishment or maintenance of bipolar cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000049">
        <property type="entry name" value="Cell polarity protein (Tea1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23244">
        <property type="entry name" value="KELCH REPEAT DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23244:SF456">
        <property type="entry name" value="MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="91"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="542"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1250"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="866"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1127"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="120"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="553"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="594"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="674"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="684"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1267"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1281"/>
            <end position="1291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGZ32188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1497" mass="160718" checksum="0513EF9A52A8A450" modified="2018-09-12" version="1">MAIFSSSKKSKKDTPNTTGTSQPLNQSQSSNGFSRSASGSLVASVDRPPGQPLPTSPSSSHSQLQATTMGQSFHPFAAKNALTAATRTLGSDEGANEAATDMAPGGPESSPAPSVNANARGGGSGGGYAGNGGSGTSLSTSNIAQGTTSLQTHSNSLVSQSQPAGQSSHTVLYPWAQRRLVFAPTALFPPLDSNNPTAAPAIVGPVSPPPFPRYGHSVNPVAAVSTGELYIFGGLVQNAVKNDLYVLNCAGGIVHTTSNLPSGLSASSPISIGLVETRGEVPGPRVGHASVGVGNVLIVWGGDTKSRPEDLQDDGLYLLNLSTKEWTRVKTIGPAPEGRYGHAASMVGSKFYIFGGQKDDGGFMNDLVWFDLQKLKAGSPKWTFIDYASGAVVPPRRTGHTTVTHGDCIYVFGGTDGQYHYNDTWCFDTNTGIWIELSCIGYIPVPREGHAATLVDDVMYVFGGRGVDGKDLEDLAAFEITNQRWFMFQNMGPAPSGRSGHAMATWQNKVFVLGGESYTAQRHDDPGFIHVLDTSKIKYPSDAVRQSSVPRKMSSPTMGTPSSPTGNMPRSNREEDRRAASPNGSQRGGRLSPNGGSSHSSFGQVFAPRRNGSPASPPSTLAHGSKRTYSSSPPARPARPETLPSPTMGALESASEERALSPSGSQRPRGAAPSPFPSSPIQPGPSSQSLSASAASASQFGDRTANGSSSAVAEPEAVKTPTPLASAIKMNGVMTRDSNDDSRGQDAQSHSELILKDEEIAVLKARELWLTESLSLATQRGYKVTVGAREGESSASATPSDPAIFAMILQVKENLAETKRFLAEEAETVEERVRQANAGRIVALQEAAYYRSKAAALERGIPADFAAVERERARSLEDKLAQALATRSALELRVTQLELDVDRHVDLRTVLEEQRAMATNRADAAEASYARALSDCAEVQRRAQTHESTIQVHAQKIVTLTAASSQLEAKNSSLGRDLESSRTEVDQHAAAVEQTHAALLAASNRNDELHGLWEKATADATEHRSRGAKLQTELDAQRAEFAALSDRATNLERTLTSTREAYSKAQILITNGLVGLTASRHEQQNQDVGSESTEQVERARALERERDDVLRLHQEMLTKYATSTSELDGALQREALTRSQLAELQNELASCRQQHALAVDEAARHRSALLGAEDKLNAATQIKEAAEVKSVLMRSVLSDHGLSPVADADLATRFPPLSGTDSPELLQRRAEDLEARLEQRAGAYREVEASLASERKTSASKVEALQRSLQDLQSRSPVESSADRERATKAESDLATLQERHRQLEGTHLKAVSYVKELTRYKERCEEFEAKDKAPRPEHVAELETLRSALTQAQNTSGELERQITSLREEHTRTLQTSRVQSEQQLHQMTGEVTRLDKELRKAQNDLEETLAVNASLNKELTSALKNTGSSTRGSPGADEMGRLEAELTQAQNKAEWLKRENAQLETRCRTAESKISILLDHLEGTPAEASEGAGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LPG7</accession>
    <name>A0A2X0LPG7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C011g06556 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C011g06556</name>
        <name evidence="3" type="ORF">BQ5605_C011G06556</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LPG7"/>
    <dbReference type="STRING" id="796604.A0A2X0LPG7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046496">
        <property type="entry name" value="DUF6589"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20231">
        <property type="entry name" value="DUF6589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6589" evidence="2">
        <location>
            <begin position="349"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY12614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="698" mass="77970" checksum="5C47CAB17DE1150C" modified="2018-09-12" version="1">MTRRLARIAAVRRIYSLIFGFTSSHYVNTSRGISAHQHNTMVHNHRPKLFNSNWTGSSMYLISLYNSNSPAKLAQTHEAESIIGSPTRWGLLNTCILPVQSDSIIVKEMKRTKSAFVSSHDMAPEVLASDQIDARLDAIVESNSFISGRIRNLLSHCGDPPPVEESNCDKLSSDSTDVDMEGAQEDSSGSDAERGCFSLPRSNMYYLCLCRAIMGQIAFACNRRNNAMQRRNGLMALACGANDRLTTFLYDCGLTTSRRTTRRAALSLTMANLALLKEIRSTRYFHVTLDNIDVAHHVNDEHLDRRSEPLHGTLGYAHVQNGDVANAYDFQAYIAHQALLPPVDVNLPLPAEASEEAFATGFSAQMYRALARLVPHLGLTLHDSRCRPEPIEQLDVRKPDITLLQMMDESDTSPTDVAKVINRLRTQLGLSEKEKADSLWILGCDGGTSMLVEDYNYRVPGVAHLQWIEISRSLFITANLLGRKGPEPQKIKDYNPMERLLRDTAQLELLSCLLQTHLTGLDVAIMKVFDRYLHSDPVQRAKVNMEKAPVFYESLLRLRDLVDFEEAYYATLPLKAFPTTERICHTYSFFSSPRQICRPRGVRASCVTQSGQRDLLELIVISTDRKADSLNSIDGDRQGVRLTSVGVCTGMVDHEGGSDVVDWRCGPKVRPVRPGWLIHVGAKNRPSGSVRKPAPSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LPS2</accession>
    <name>A0A2X0LPS2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C010g05830 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C010g05830</name>
        <name evidence="2" type="ORF">BQ5605_C010G05830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LPS2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY13315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="121" mass="13274" checksum="731B1CBA141F4D56" modified="2018-09-12" version="1">MLGHNKTRRRPLKTSTSAVPGLSKPTFCLCLLIPPLTQNPEAKECEPPSRNSVFFFFFFFFFLTGAHKLQSFGLAGTATKRAKGGYKATTASSWVKVKPLRAKSAAQIKARRAPNADSNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LQN6</accession>
    <name>A0A2X0LQN6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C010g06123 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C010g06123</name>
        <name evidence="3" type="ORF">BQ5605_C010G06123</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LQN6"/>
    <dbReference type="STRING" id="796604.A0A2X0LQN6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05840">
        <property type="entry name" value="PWWP_ScIOC4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035503">
        <property type="entry name" value="IOC4-like_PWWP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12550">
        <property type="entry name" value="HEPATOMA-DERIVED GROWTH FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12550:SF70">
        <property type="entry name" value="JIL-1 ANCHORING AND STABILIZING PROTEIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="2">
        <location>
            <begin position="16"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="390"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY14265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="410" mass="44939" checksum="114779DFCBEE1A1C" modified="2018-09-12" version="1">MSKKGAAPSVDKSYTPGDIVLAKIKGYPSWPGQITDGKDAPVNVRSQQPPKSKTYLVRFFPTGDYAWTARRDISSLTKDEIDTYVSSSSKKKGDLLEAYKIAKDPSSWLKMREDEANAVAAYDDEDMLASADEASGSKGKAATKKRKAVAAKKDPVEDKKAKKAKLEKLAKTRAPPKSTKKAEKEEAEAAPPSKKSKPTPAPAPVEVDDPGLKQVRDWRHKLQKVFLSNKNEVPLNADVSHYSIVTIPNPRQPIELMVPHFDPQEMPKCREYFDAMETFDMKREWLAESKLAKVLKRIVLLNPNQIPDEETHKFRERSTALAQKWASLTDPSGQATPKEDGTAKSEEHKELAAASTETPNDSSAPAEEYKDKMEGVTETNGTNGSATTQAADASPANDAATTAPQDEVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LUI4</accession>
    <name>A0A2X0LUI4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C014g07658 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C014g07658</name>
        <name evidence="9" type="ORF">BQ5605_C014G07658</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY19475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LUI4"/>
    <dbReference type="STRING" id="796604.A0A2X0LUI4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050151">
        <property type="entry name" value="Class-I_Pyr_Nuc-Dis_Oxidored"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912:SF151">
        <property type="entry name" value="DIHYDROLIPOYL DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912">
        <property type="entry name" value="DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="8">
        <location>
            <begin position="33"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY19475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="105" mass="10948" checksum="1309E6453D58A799" modified="2018-09-12" version="1">MLALRSSSRSVVRATSRLQPVFARGLATASDPYDVVVIGGGPGGYVAAIKAAQVGLKTACIEKRGSLGGTCLNVGCIPSKAMLNNSRIFHQTLHDTKARGIDGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LUN6</accession>
    <name>A0A2X0LUN6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C010g06079 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C010g06079</name>
        <name evidence="6" type="ORF">BQ5605_C010G06079</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LUN6"/>
    <dbReference type="STRING" id="796604.A0A2X0LUN6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="186"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY14143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="418" mass="45231" checksum="3DDCC6172F2E80E6" modified="2018-09-12" version="1">MTSKSSVLHQTFKSTASTRAPSSYASGSSSSSSSPSFFPLASSHSARVVHPPTAYWYTSRPSLNATLASLERTLNQSRTHLFKCGLLRSIATPLSSSEFASSLPHPRERRWKDAKEMGVYLRNGTDLRTSEYRRLTGVLAHLEGLLPYAKLGDELPPPSTTSPQGINRSVLPPSLVVDPVAANQALASRSQQKDAPAESAESAESAEPESEHEDVDSYRGSATTLSGQLDVLLSRFVAPAVLSATGATLERVSGAARRLGRMDHHGRVNAVGRRKESTARVWIIPASSAATESTEQDPTPGRILVNATSLPEYFSVASHRSAVVRPLTLTSSLGVFNVFAIAEGGGIAAQAEAVAMAMARALAEWERCKIEQGELQEGEVTWREILKKANLIDRDPRMVERKKTGQAKARKKFAWVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LVQ1</accession>
    <name>A0A2X0LVQ1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C013g07331 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C013g07331</name>
        <name evidence="3" type="ORF">BQ5605_C013G07331</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LVQ1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY15335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="268" mass="28225" checksum="93CA003EAA5B1C1A" modified="2018-09-12" version="1">MGEIPRTWWIVIGIATFFVVVVSLVFGLQMVMRCNERSRDRRMEEGARANKILGKTRESSSGSASDSTDSLDKEKENMSTVSSAQLSSFNLSAAPSFSTLPNPHAMSTIPTARSPQGYAVHPLHNAERLITKSYDSLRSSPLAGPPTTSSASVTGGPPSRASSSLSKSSSQPSSPKSPKSSTSRSTASRTPSPSVVQEDSEEGSTAGEPSGDEASSAAQEEAQRPVQVRAARSPSSSTAPRLSLPELPPFDTGLMGEEITSEDHGKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LVW4</accession>
    <name>A0A2X0LVW4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C012g06684 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C012g06684</name>
        <name evidence="2" type="ORF">BQ5605_C012G06684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY15860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LVW4"/>
    <dbReference type="STRING" id="796604.A0A2X0LVW4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY15860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="310" mass="33935" checksum="1370021C282E1D3B" modified="2018-09-12" version="1">MAPLWFLSCSSNCEESTLRLVQDLGARSEPGASRTDLCARSEPGASARDLGARSEPGEMARDLGARNEPGLLAHCRRRRRQPATVATASKVVFPKHARLDGPKSFTNWLRQLRLALPNQLRAYVLDGVAPATWTADQLAARDDTAREIIVGSIDSADVSATLDAIPSDDLSAPRIFAALKARFAPDDATRTLELFARLWDFRKMPASVDAYDTWLREYMSIAQEIRDAKTSLNDVLATHVLAMVPSCLDSFRLTFTDEQRNQRDLPELTTLTDRIRIQLRSAGLSTSHSAMIATTSLAPPATPPATACAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LWG2</accession>
    <name>A0A2X0LWG2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C012g06752 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C012g06752</name>
        <name evidence="1" type="ORF">BQ5605_C012G06752</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LWG2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY16073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="78" mass="8396" checksum="052A57B9D2A59243" modified="2018-09-12" version="1">MRSKIGDFPGFYLRASGWAFMGPLYRSAAPRPSLQAASSPPHDFSTGEYFASPSCLATSRNDPVRAASRFSSDPPVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LX18</accession>
    <name>A0A2X0LX18_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="28">BQ5605_C018g08800 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="28" type="primary">BQ5605_C018g08800</name>
        <name evidence="28" type="ORF">BQ5605_C018G08800</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY26816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0229">DNA integration</keyword>
    <keyword evidence="20" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="18" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="21" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="17" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="18" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="19" id="KW-0917">Virion maturation</keyword>
    <keyword evidence="24" id="KW-0862">Zinc</keyword>
    <keyword evidence="24" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="26">
        <location>
            <begin position="296"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="27">
        <location>
            <begin position="545"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="869"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="919"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1502"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="873"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="SGY26816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1562" mass="171723" checksum="7DC5F9AEC76B6936" modified="2018-09-12" version="1">MDSSPASPLAPRDPSSPESSIGEQIATLQAQLAALQASQPAAAAAAATPAVTAVPGNAATASKVVFPKHARLDGPKSFTNWLRQLRLALPNQVRGYVLDGVMPPTWTADQLAARDDAAREIIVGSIDSADVSATLDAIPSDDLSAPRIFAALKARFAPDDATRTLELFARLWDFRKMPASVEAYDTWLREYMSIAQEIRDAKTSLNDVLATHVLAMVPSCLDSFRLTFTDEQRNRRDLPELTTLTDRIRIQLRSAGLSTSHSAMLATSSPCPACRAPGHRLRDCTSRAKHPPTGPCRRCHKKGHWALDCKNRGEQARSSDDTQDNTSSSAALQPNVGYFASCLFARRQLPTDAFVVDSGATTHMVADRSLFTTYRQTAHTKISGIAGGITAIGMGDVAFVTKTGHPITLRSVLHTPGLHVNLLSVARLCDTDRVRLTFTSDGIDIARDGQAIAHGTRVNDGLYLLDADHTKCQQLAFLSRSESTVPLITLHRCLGHLAPSSIQKMIAAGLLDGFGAGYSDKDVEEFVCNACLGSKGHRLPFPDSESHSPERLGLVHSDVLSFPTPSLTGKRYLVTFLDDHSRKLWAYAIDHKSNVFPIFQTWLAEVELATNARLRILRTDNGGEYRSNAFTEFCKSKGIHRQYSIPYTPQQNGRAERVNLSIVEGVLALLADARLPATFWDEAAAYFVYCKNTCSHSALAKQTPEFVWNGQRTTATALHPFGCTAWLTVAPDLRSKLDPKAARVIFTGYDLASKAFRFFDHSINKIVLGRNATFLDNDFPGLPVTTPVDADDTDRQFVIPADTPALAVKTRTPLCLSRCVTSNFLVWSPLVLRSETYHCLSRCVTSNFLVWSPLVLRSETYHCLSRRDNITRSSSSPSLSPFSSPATSSARDPSLSDSDDPLDLLSSNTAVRLNLLDVHRSDDDTPETQAPAVDPVGQPSDDDSPDEIDFLSRHHRAFIATDDDDPTLDAIEPVKSITSDPQTWREAMSSDEHNIWAEAAATKFTAMRDDFKVFTIEPRSTLPPGATIVTSKFVWKTKRDARGDVTGRKARLVAQGNRQRDGINFSETFAPVARFSSICCLLALAAANGYHVHQADIDKAYLHGELDHDIWMTTPRGFDFPSNKVLWLRRSIYGLQQAGRIWNRHIDTSLRNLGYKATGTDHCIYSRIDDQQRPHYIALYVDDLLIVSPGLDEIERVISGLEQRYGVKRLGPAEYILGIQIRRLDDGSIALSQERYIMDVLVRFHFDTTTRGTTVPMTPGLSLTAIPGQGTERIRSWYLQAIGSLLYISLGTRPDIAFAVSYLSRFANNPGRRHWIAVKHVLRYLCATYRDELLYARGPAKVTGVVGYSDANWGACVDTSISTMGYVFYLAGAAVSWSSKRQTRVADSTTDAEYLALSHAGKEAIYLTQLLSELHVSPIAAAHIFTDNEAAAAVAHDPVRTSGTRHIRLREHFVRDMVNRGDISLSHVGTADMVADVFTKALGPKIFGTHCFALGLRTRHPRLKSTSRSRGGGVRAERAGRPGPGLRRTERGWDLGARGEPGPLAQPRGSLAVDLRARLFCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LXN5</accession>
    <name>A0A2X0LXN5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C014g07444 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C014g07444</name>
        <name evidence="7" type="ORF">BQ5605_C014G07444</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GOLPH3/VPS74 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY18692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LXN5"/>
    <dbReference type="STRING" id="796604.A0A2X0LXN5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031985">
        <property type="term" value="C:Golgi cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048194">
        <property type="term" value="P:Golgi vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="entry name" value="yeast vps74-n-term truncation variant domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704:SF2">
        <property type="entry name" value="GOLGI PHOSPHOPROTEIN 3 HOMOLOG SAURON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704">
        <property type="entry name" value="TRANS-GOLGI PROTEIN GMX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY18692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="414" mass="44896" checksum="316AF6C4EEE363D3" modified="2018-09-12" version="1">MATTQSGLSRRRGGPSHGGAQTSHNGTAPLAPGVSSPPGASLNGNSLSQRFGGVSAAATGAGGASSRPTTPAGHRVAFDERDLESSEDQIMPKLTLMEEVLLLGLKDKQTIGIVTTLLLEVVLAEKAWGYLSFWNDNISYTLRGCIVLELALRHRIAMVRDPNRRRFPLADRYIEVVDDRLTGEVLLDEALKMMKISERMSVGTWIDLMSGETWNVMKIGYQLKQVRERLAKGLVDKGVLRTEKRNFLLFDMATHPVSDPTFKDDVLRRTLGLLTARTAAVPTSDLYGERVRYRTIRAVSMVCAAFSANVLENALVHLSYDAREAAFAKCDELLAEFSQWPFAAFRPPSAGGGGIGAGSASANVENANLAEINRLARGEMSGGEGGAEGQTQRELHLEVVAAVLEVCRRCVARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-11-27" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M094</accession>
    <name>A0A2X0M094_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C016g08222 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C016g08222</name>
        <name evidence="9" type="ORF">BQ5605_C016G08222</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ATX1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY21317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M094"/>
    <dbReference type="STRING" id="796604.A0A2X0M094"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000008">
        <property type="entry name" value="Copper transport protein ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051881">
        <property type="entry name" value="Copper_transport_ATOX1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365:SF1">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="HMA" evidence="8">
        <location>
            <begin position="2"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY21317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="124" mass="13472" checksum="8DF29CDE6055B750" modified="2018-09-12" version="1">MTSTYKFNVVMTCSGCSGAIDRVLKKTEGVSSYDISLEKQEVLVHASSISYDDILAKIKKTGKEVKSGEVHRLESASSAHGAAFVKPRHEPHICPRATHALLFGPTQAQTHHSLILRSTSAPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M0S5</accession>
    <name>A0A2X0M0S5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g02085 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C003g02085</name>
        <name evidence="1" type="ORF">BQ5605_C003G02085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY38843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M0S5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY38843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="144" mass="16539" checksum="6C4962D30B63A86D" modified="2018-09-12" version="1">MSTHPSAMSISPSSRVLVVPPDAESLRLIGQHLGAWLDSRWSLLPTWRMTVLPTHAGSRAVLATHVPFWAFTALSMFPPVDAIARPMKAQPEALVLHETLSLKPFPLMTSLLTLRPPRDRSVHRRWMHWMKLILRQWTQCQRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M1Q4</accession>
    <name>A0A2X0M1Q4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C002g01121</name>
        <name evidence="13" type="ORF">BQ5605_C002G01121</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY30138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M1Q4"/>
    <dbReference type="STRING" id="796604.A0A2X0M1Q4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14079">
        <property type="entry name" value="STKc_AMPK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000407">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000236">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032270">
        <property type="entry name" value="AMPK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16579">
        <property type="entry name" value="AdenylateSensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="39"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="301"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="406"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="558"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="667"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="425"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="453"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="500"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="558"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="595"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="685"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGY30138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="769" mass="85316" checksum="8154CC5B302BD194" modified="2018-09-12" version="1">MANENNTGGHRAPLPTPGTSTSTSTSTSSNKKTVIIGEYEVISTLGHGSFGKVKLAKHTATGLKVAMKFISKRKISTAEMSSRVHREIQYLSLLRHPHIIKLYDVIAAPNDIVMVIEYLSGELFDYIVRRGKMPEDEARRFFQQIMSALDYCHSHNIVHRDLKPENLLLDEHLNVKIADFGLSNIIQDGDFLKTSCGSPNYAAPEVISGKLYAGPEIDIWSCGVILYVMLCGRLPFDDDHIPLLFKKINGGIFSLPPFLSSDARSLLSRMLLVDSNKRIKLHEIRQLPWFQKDLAPYLFAPSTTAMPPPNEDDNDEPQSPGVWQPEAPVAGEQSRRREWVEGLGIVDQEIVDGLCEKIAGLNPDDVWIKLQDGKDRELRIAYQLCRDNKRMVEGSHYDDSEAIQTFISPPGVANQRQPTIRKKPTLKDEKKDEVTPKPAPPVQSSEIRVLEMSIRRPLEENEGRQLADTRPSRPLASTRLSSPLKPMTQPLTPTERSGAPVPPVTPAPTGPTTRRLRQRWHFGIRSRSEPMEVMLEIYRTLKALKMEWKPKGAHAAQLAAAAKGEQQKQLEGGEAGAPKGSHGSHAGEKGSNGSKEGHSSGATHDEEDPKKRRRREEEERVKKAQELYFVETRCRMDDVMVRMDLQLYRIDEQNYLVDFRNLGYRPIPKSSRSSIAAPPGGGPGSIRQHPSDASGATSTESASGVTSISSPFGSLPPNTADEIRARKPEQFPTPNKRNVGAEVSSPYLFLECAVRLIVELASPAGSEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M2U0</accession>
    <name>A0A2X0M2U0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01501 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01501</name>
        <name evidence="2" type="ORF">BQ5605_C002G01501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY33468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M2U0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY33468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="371" mass="40458" checksum="6DB10B5B0C37573D" modified="2018-09-12" version="1">MAGSASEKDKENQRRNGKGTGSGSGSGSGLGSAGSGSSAQASGGLKLGPRLVRAKKYIDADGMYARKDKGNMGLRDYTCKRGQIDKIYYNWVRSVVRDALVVAGIRTPTPVQLYGPLAEINQEWSPNHDLPENYDLKDAFRLISAKTSTNTVLWGNLSPFKQREIVKYIRERAGFLAVAGFLAVTSGDWLYEELVIDVLANIRSAWKLAYDREVCRLAGIKGQLSKADIATLRSRHGEGPSRKSQDGVYSASDTGTSDLEEEEVLATRNRTLVPKKRGARQGAGSPQLSQETQQTSPHVGSSGQRSTPAASGVRGPGPPRNKKKKTEHNPNRSQQTNPKRDLGNGRAEEEEDEDQGQDEEEVEELERSPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M3M7</accession>
    <name>A0A2X0M3M7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C003g01884 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C003g01884</name>
        <name evidence="4" type="ORF">BQ5605_C003G01884</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY37763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M3M7"/>
    <dbReference type="STRING" id="796604.A0A2X0M3M7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016160599" evidence="3">
        <location>
            <begin position="22"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY37763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="313" mass="34462" checksum="DECB4548149F0FB6" modified="2018-09-12" version="1">MRIMNLALLATLSLSPSLIEAKGPIGLVLDGFELVGNTSRGAIKGVLTGVFGMNATAVDKVFTNEKKGLPKHPYALDLTDENYDTVFSTGTYTPYSRDLSEDTVWVVHVHGPDPISRKLGEAFDQVALVNSSQAGGELPSNMRFARLDYNEETFLTTLWWMWKPPVVVIFNLNTTTHQIDYRFFSSRMLIPHAVPLSNLLNNRTTWETVPTWNGILSPHGLLGSVVPHVARGWTYYHHTVRRVPNFILLMISGFVMNFVVAWFHQQPPPTPGGAPTAAPPVAAAEEKKGAKKDEGKVIKASATQASLASKRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M4H7</accession>
    <name>A0A2X0M4H7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GDP-mannose transporter</fullName>
            <shortName evidence="5">GMT</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C003g01942</name>
        <name evidence="7" type="ORF">BQ5605_C003G01942</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Golgi apparatus membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY38014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M4H7"/>
    <dbReference type="STRING" id="796604.A0A2X0M4H7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY38014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="423" mass="46003" checksum="C9449FAF3D2F67C8" modified="2018-09-12" version="1">MSESKADYTLAMNDDGKIGTDTKPQHDLESSLPLLDRASRPTAAPPPPPSRRSSEMQYRSATDRILNHSALPVFSYCVASILMTVVNKYVVSGSHFNMNFLLLAIQSTVCVGCVAACKHFDVISYRDWDTNDARKWFPISFLLVCVIYTGSKSLQFLTIPIYTIFKNLTIVIIAYGEVLWFGGHVTGLTLISFALMVVSSLVAASSDIANFLSGTPIVTKAGGASSAGYLWMFANCFVSAGFVLAMRKRIKITNFSDWDTLRYNNLLSIPVLAFFSLLVEDWSSESLAANFPEENRFALLSLMAFSGAAAVGISFCTAWVIRTTSSTTFSMVGALNKLPVAASGILFFGDAATVANVVGILLGFVAGLVCELVVMVHPRRALQGRKRHLTNPLIFWLLIDAAAKSAQKAAREFQSPTLSGLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M4P3</accession>
    <name>A0A2X0M4P3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C003g02073 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C003g02073</name>
        <name evidence="8" type="ORF">BQ5605_C003G02073</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY38794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M4P3"/>
    <dbReference type="STRING" id="796604.A0A2X0M4P3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00432">
        <property type="entry name" value="Ribosomal_L18_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.100:FF:000002">
        <property type="entry name" value="60S ribosomal protein L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_A">
        <property type="entry name" value="Ribosomal_uL18_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005485">
        <property type="entry name" value="Rbsml_uL18_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057268">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025607">
        <property type="entry name" value="Ribosomal_uL18_C_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410">
        <property type="entry name" value="RIBOSOMAL PROTEIN L5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14204">
        <property type="entry name" value="Ribosomal_L18_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17144">
        <property type="entry name" value="Ribosomal_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00058">
        <property type="entry name" value="RIBOSOMALL5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL18 C-terminal eukaryotes" evidence="7">
        <location>
            <begin position="236"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="250"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY38794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="301" mass="34485" checksum="CAAA0BB18DAD13FC" modified="2018-09-12" version="1">MPFVKTVKNDAYFSRYQVKYRRRREGKTDYYARKRLVAQAKNKYNSPKYRLVVRITNKDIICQIVSAKLQGDVVLTAAYAHELPRYGIEHGLTNWAAAYATGLLVARRALTKLGLADKYEGETEPTGELQMTEANDDGPRPFKCFLDVGLKCTSTGARVFGALKGASDGGIFLPHSAQRFPGWDFEAKELDAETLQRYIYGGHVSEFMETLEEEDEERFRKHFSSYLADDIGSDDIEDIYRSAHEKIRESPEAQITDKADLAKWKEASRKTHPKKLTLQQRRERIQEKKDAWLASRGNDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M536</accession>
    <name>A0A2X0M536_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g03806 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g03806</name>
        <name evidence="2" type="ORF">BQ5605_C006G03806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY53824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M536"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY53824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="114" mass="12906" checksum="2F5810E6EB6C3701" modified="2018-09-12" version="1">MRPRRSGESSTSRPQSQPNGDNRVKNVLDAHSRFLANSQANLMQACDATWARTQAAKDNLAHQRALDQLQMERSKFYFKEVLSWPAEVQAQYRLVTNVDRFLCGEESYAIGSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M684</accession>
    <name>A0A2X0M684_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C001g00249 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C001g00249</name>
        <name evidence="3" type="ORF">BQ5605_C001G00249</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY45124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M684"/>
    <dbReference type="STRING" id="796604.A0A2X0M684"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="17"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY45124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="207" mass="23152" checksum="189BBC67C76A0B9F" modified="2018-09-12" version="1">MKMHGTGFAGRIHNLNVPDRPMREVGLDFVGPLVPSNGNDALLTVTDRLSGYVRLIPCRTTDDATTIADRFFEGWHRHFGMPRVLVSDRDKLFTSEFWRAYMGQLGTKLATSTAFHPQTDGRSERTNRTVIQVLRTMVNRQQNDWSKHLATVEFVINSSMNRSTGKTPFEVVLGFTPELTPITPVEGVEIEQRCAEQVGGSGKPMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M6J2</accession>
    <name>A0A2X0M6J2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00359 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00359</name>
        <name evidence="2" type="ORF">BQ5605_C001G00359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY45922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M6J2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="377"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY45922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="403" mass="46313" checksum="FC47DA363F3A4342" modified="2018-09-12" version="1">MAPRATEGERAWLDIDSHLIDLIRDESGQWRVRCELCNKHYKLPGRYRSLDGPTRAFNSSTVDSRYRCNEAAFELIGTDREVQAGFGHLKKRYRRQLQAKLDMLEAPGKADRARHDEWAAERARRLVMEPKDIMTQDPIPEDVENFDYQVREEIDYVMWPVWDEWAGYKGNGRLPRSLLTVLIHWRNVLFDAYDNQKRKRGGGSARVLKEYRTRIQDFDDILARIFTVPVDIAAEHEELRLFSEILSFLYQECQRPLPEDDVRTDEDQERDEHRTWQAALRPFATTVLVHVPKPPKPPTDADLEPERKKIWDSWIVECAHMWLALSSKQRDAYCWMRKKGSGGEGAASTSGAREEDAISEHSSATGQHSDHGSAAGSEAESNLSTLSELTSLSELERGLDTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M786</accession>
    <name>A0A2X0M786_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C007g04480 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C007g04480</name>
        <name evidence="10" type="ORF">BQ5605_C007G04480</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY60748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M786"/>
    <dbReference type="STRING" id="796604.A0A2X0M786"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015851">
        <property type="term" value="P:nucleobase transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000002">
        <property type="entry name" value="Purine-cytosine permease fcyB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF1">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="241"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY60748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="476" mass="50941" checksum="BA5B2F808146DD26" modified="2018-09-12" version="1">MWAAVLWADSFGVEVRGVERVPEDERHHARPSDAGALWASANMTISTFSLGTLGNSIWYLELTDACLTILFFNLLCTIPVAIFSTWGKSTGLRQMIVGRYSFGTIGIYIPIILNCIACIGWSVVNTIVGGQALAAVSDTHNLPVVAGIVIIAGVTLFVALFGYKIVHTFERYASIPVVIIFVIMLGQAAPHVTAAMGPPGAATAASVLSFGATIAGFAFGWTSLASDYTVNLPAETSNTKVFAWTYMGLNLPLIFVECLGAIMMATFKQKSTWEDAYNSHHLGGLLGAPLVGPMGGFGRFLLVILGLSIIANNIPNMYSFALTFQAFGKAAQSIPRMFLVIIGTVIYIGLAIGGRNSFESVLDTLLVILAYWLIIYSVVLLEEHYIFRKGSFARGYDLDAYNTPSKLPIGLAAIGAICFGIAGAVVGMSQTWYVGPIGKMIGPPPFGGDIGFELSGGFAAVVYPAFRYLELKYVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M9U8</accession>
    <name>A0A2X0M9U8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C004g03100 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C004g03100</name>
        <name evidence="5" type="ORF">BQ5605_C004G03100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY70083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M9U8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019783">
        <property type="term" value="F:ubiquitin-like protein peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="4">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY70083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="122" mass="13755" checksum="1BC2063BDDFEBFE2" modified="2018-09-12" version="1">MFKVCLDNISSNWHTPNSVWFMPICDENHWFLGRIDVKHGAWSIHNSLSSRKLTVAALNALEALFKVLNLIIDVNHGTTTRAPQQQDTFSCRPAIVNVVEHKLVHEKAFDPTHAALSRAEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MA55</accession>
    <name>A0A2X0MA55_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C005g03212 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C005g03212</name>
        <name evidence="1" type="ORF">BQ5605_C005G03212</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY72802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MA55"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY72802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="61" mass="7042" checksum="D2941E9D10515566" modified="2018-09-12" version="1">MPRIEDLPCSSNYTSGQRSFLQRSSLSIDLETLGRVDFARWMMGGQPLEVFGEEFDNPKDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MBF9</accession>
    <name>A0A2X0MBF9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C010g06022 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C010g06022</name>
        <name evidence="3" type="ORF">BQ5605_C010G06022</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MBF9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="345"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY13995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="374" mass="40450" checksum="59874661EC59869D" modified="2018-09-12" version="1">MSFTGSVWDGSSSPVLSRVYSAHSFLNNNKPHPASPFTLFAIIHAVRIACAYRGVARAGGWDHRIGLFQAFTVPLVLILGGTTITSILMGAVPGWLISPIPVATYGLIPLIASESGLVSFLLSTPRLPRDLLFSTVDGFSRVVGMTTLGVDTVLAHPNPALRNSPWAMVLVATIAGGGGGMLIPAMKMFHADWGFDATPAWVRDGPGVDIWGATVIGYVYALVFLQAEHVEKPLTALVFALHDHSTLIDAHPFFRLLPKYLLTIFPFGSNWFHLPKSYYVNPSPVPLLPNHEAKIFCSVLLSLMLCTRTLWPYLQSNRKLTASSLNKKNKKVTPTSALTSSKAMAAVADKPSSSSSAVSVDEKNKQGLKERKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MBL3</accession>
    <name>A0A2X0MBL3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C004g02619 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C004g02619</name>
        <name evidence="1" type="ORF">BQ5605_C004G02619</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY66065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MBL3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY66065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="189" mass="20749" checksum="0EBCF077A169F8A9" modified="2018-09-12" version="1">MVAFDHNTNLKWRAVSRLEHDTKGLVLRSEALKAYIISDDSELDALAVGVQWSAGQKWGSEDGFKIFVADVSRGVKHAPAIQTKVVVCCNSQVPFPTSAGQVPSNDNCPDVVHLFRVNTLSQLFPHGAAADKLRRWAITKQEIEAIEARTGLKLADYCTLNEVFAFMELKSTRGEWYAAEAQALGISTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MBN6</accession>
    <name>A0A2X0MBN6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C010g06092 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C010g06092</name>
        <name evidence="3" type="ORF">BQ5605_C010G06092</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MBN6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY14180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="170" mass="18420" checksum="08FE661D23D53B9B" modified="2018-09-12" version="1">MARSPKSYDPSEPRDPKKALPYTYPYSDNIVADIVPGLKKRLSLPSKTKLTPLHLSHPPSTAPDTLAIVAAMFASLAVITRYPVYIYFGFLFSISAINTGKKLDKSRRATSVSGWSGLLFALTAFLSVYYPLVSGVAVKAPYDFWSKPFPLGLGAGTIPAPRLAQVVEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MBU2</accession>
    <name>A0A2X0MBU2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">BQ5605_C008g04913 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C008g04913</name>
        <name evidence="14" type="ORF">BQ5605_C008G04913</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY78685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MBU2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18597">
        <property type="entry name" value="ABC_6TM_YOR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18606">
        <property type="entry name" value="ABC_6TM_YOR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000061">
        <property type="entry name" value="ATP-binding cassette transporter YOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000010">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0843">Virulence</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="340"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="434"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="465"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="918"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="955"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1034"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1057"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1166"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="208"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="627"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="922"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1257"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="541"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="600"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="566"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="625"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGY78685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1546" mass="170462" checksum="CE7F92795CD825F7" modified="2018-09-12" version="1">MVANVPSPSSSVTRGDTGSKEDVERHSEEGSHQDDLAHKPTFGDLEKQQTNATQASAILKEKPKLQRNKLKFIPFLGRVQPRDPYPSLDEAADWPKPSLLSIWTFHWIQPLLIVGYQRTLVATDLWKLPPTMECGPLADQLMENFERRRKDVEAWNQSLDNGSFKPSVLRRGWWKMRASIGLGAADGRRKPGLALALSDTFKYQFWSAGVIKVVADTAQVTSPLVTKALIQFSTKAYYHAKGVPGYEPQSVGYGVALAIIVWLMQVIASLGSHQFFARSASTGVLARSTLIASIYRRSTTLSGKARTVMTNGRLVNHVGTDVSRIDFAAGFFHMSWTAPIQMIIIIVILLVNLGPSSLAGIFFLFLSIPPQGWAMKKMLAARKRAMVWTDKRAKLIQELLGGQRIIKFFSWQQPYLRKLREIRESEMFHVRNLLAIRSATSAVAMSMPAIATVVAFLVYSGTGHSQNSAIIFTSLTLFNLLRMPLMMLPVSLATMTDAHNALGRITEVFLAESRSGTYQFDAASEFAIQVDDADFQWEGAPPEEAAAGSKKEQQALVHKLKQEQKKAKHDKKKSEKKKLPAPEQVIVDEKKPGVALDLANKAPADGVDAVDTDVSRGVPAPAEPTPDESQDESPADKEEDLMQLSHISFRIPKGQLCAIVGPVGAGKSSLLQALVGEMKRTRGSVTFNGSLAYAPQVAWMQSVSLRDNVLFGQPYDQARYERAITNACLDADIEMLPFGDATEIGEKGVTLSGGQKQRVNIARALYFDADIVLLDDPLSAVDAHVGKALFDDAICGALKDRTRVLVTHAVHFLPRVDWIITIDQGRIQQEGTYADLIADKDGPFSKMIAEFGGDATEKREEEEEVEEDAIAAAGGELVDAPKKMKKKGKGLMQEEERATGAVDGGVYMAFLRAAKGHITVPLLILSLALAQGAQVLGSYWLVWWQENHFHTQNGFYMGIYALLGILQAVFSFLMGLASVFIGYNASRSLHRGAIQGVMHAPMSFFDTTPLGRIMNRFSKDIDTIDNTLNDSMRMALNTFGSVLGAIILISIVQPYFLIVVTFILCCYFYAASFYRTSAREIKRLGRCITRLGTHRWHANLSRLSSSDNLLRSSLYAHFSETLSGLATIRAFGETDKFLKRNEEYIDIENRAYALTVINQRWLGFRLDMFGGLLVFIVAIFGVATRTKVSPAQTGLILSYILSIQAAFSWMVRQLAEVENDMNSVERMLHYANNLEQEAPSDIEETRPDPSWPAHGAIEFENVFMSYRPELPPVLKGLSLRIEGGQKIGVVGRTGAGKSTILQCLFRMVELQSGKISIDGIDISKLGLNQLREKIAIIPQDALLFSGTLRSNLDPFNVYEDRVLWDAMRRAYLVDQVPAGEVTPAPATATTTTATATATAATGDETAVTAATTATSRFTLDMVIEDEGLNLSVGQRSLVSLARALVKDSRVIVLDEATASVDLATDSHIQQTIRSEFNDKTLLIIAHRLRTIIDCDRVLVMSEGQVAEYDTPINLFRNKDGIFSSMCSRSNISEADILRKAVFKATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MD27</accession>
    <name>A0A2X0MD27_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA-processing protein 43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C004g02718</name>
        <name evidence="12" type="ORF">BQ5605_C004G02718</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY66899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MD27"/>
    <dbReference type="STRING" id="796604.A0A2X0MD27"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11369">
        <property type="entry name" value="RNase_PH_RRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033196">
        <property type="entry name" value="Rrp43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF9">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="10">
        <location>
            <begin position="106"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="11">
        <location>
            <begin position="261"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY66899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="340" mass="37240" checksum="3D38C0F09AA31C28" modified="2018-09-12" version="1">MSIENEANASAGPSSLTPALFKRLHPKPYLERFLQERLRPDGRPLDHEHAAWRDASINIGKMFWTDAWFTWSRVWRRSVLAELAPPERAQRHPMQWKPETKGSCSIATAPSSALVRLGKTTVVCGITLEIAPPDMATPTHGFIVPNIDLPPLCSSLFRPGPPADEAQVLSSRLRDTLLSSNYVPLDSLCIERSKAAWVIYLDLICLNYDGSVLDASVLAAVAALRNLKLPQATWDVDTLSTICEPISDEEPGRALQLAETIPLTLSFGLYEDDLLPDPTLFESQLCTSQISITVSASSSRLLQVQQSGATGSKSSVEILKACLGQARTRAKQLLVLLNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MD92</accession>
    <name>A0A2X0MD92_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C004g02778 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C004g02778</name>
        <name evidence="3" type="ORF">BQ5605_C004G02778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY67475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MD92"/>
    <dbReference type="STRING" id="796604.A0A2X0MD92"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050466">
        <property type="entry name" value="Carboxylest/Gibb_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024:SF24">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024">
        <property type="entry name" value="ARYLACETAMIDE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="60"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="1">
        <location>
            <begin position="283"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY67475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="352" mass="39552" checksum="B7D66CEF13898210" modified="2018-09-12" version="1">MSKHSTRHTFTYKTEPVNILCDVYLPDETKFGVVAALTRQILASAGGKHSVVDDHKLPVLIYWHGGGLTAGNRREWTPHWLFNDALDAGFIIVSADYRLLTPSSAHIVIEDAKDLINWVHTQLNVHLSNISSQLADVDRVAVSGSSAGGYVAYQACLHAQPTPKALCSIYGAGGDFLLDHWCKPKTEPWYKNRPLLALDDPRFQAIHETSKTKAATTGTEKTDLRNEYAFWLMQKGHYLDMVSGEKGLGERLRGLKYVERAKAVPEQARITFPQFGIEQAETFPPTIFVHGTTDEAVLIEESRNLAQTLRKKGTVEVELLEFEAKNHMFDVEDEYVELKKVVPFLIKHINQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MDC3</accession>
    <name>A0A2X0MDC3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C009g05587 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C009g05587</name>
        <name evidence="2" type="ORF">BQ5605_C009G05587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY82687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MDC3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY82687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="341" mass="38930" checksum="6A03656A69DB6EC4" modified="2018-09-12" version="1">MAGRAEAVSRSPYDADYAAFANYAKVADLFRRELYPGGGFHLWTPPTDVVVSNSEYDQQGRPQREHIVAWYRHAINRLRFTPIAQPVAAVRINGPPRVRPRSEVRPTTPLESILPHPIDPPQRLPRPALPDQSTQYNLLSMDRPYTIRRVRRVLNAKAFTDTIGFRDSLQPDDLKGFWKGVNSKALTAREREVWFKLVRNFTPTRSLQFHQKHDDSPACLVCGAPKDDREHYFFDCVDSRNVWIAARGVLCDALGLDTIENTHYTAVQRMFGLPKLKASLRDQEGAGRTIEIFTGLVLEMISSGRWGMQKWGKRMEGVGRRRIILERLKLRAGGAWGRRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MDR8</accession>
    <name>A0A2X0MDR8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C004g02938 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C004g02938</name>
        <name evidence="2" type="ORF">BQ5605_C004G02938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY68995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MDR8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY68995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="240" mass="25842" checksum="29D776D47B885C4B" modified="2018-09-12" version="1">MDHHPGQSLDRRPPTSPGEVLSKVISIQRKFYNRTALSFPHNSPVTRAFEAIKTALLLANRNWIHSGPLAFGPLGQIGTASDEVARLAWTKATDGKVKQFSDGSDTNGYGPGFVEVDAGRVVGPATFRGAWNGANAGGGVRSPEDGPPGYVPPSPQDERPPINGADGGGGPIVDEVEQARMKLAQMREQRLRLEEAEEERKRMLEIERKEMEQAIANAVQSHVGPTTNHGTSESRSTTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MDS1</accession>
    <name>A0A2X0MDS1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C005g03361 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C005g03361</name>
        <name evidence="2" type="ORF">BQ5605_C005G03361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY74400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MDS1"/>
    <dbReference type="STRING" id="796604.A0A2X0MDS1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39470:SF1">
        <property type="entry name" value="CHORISMATE SYNTHASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39470">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY74400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="371" mass="41668" checksum="EA4A697FE42F6C24" modified="2018-09-12" version="1">MIITISSSTLTQTLLLFLAPFLLPRLIRFVTAFLYPKAAPPHGNDPPPHNSPFLSTRHVEPPLPPRLKLARLCLVTLTISSLLARSLIPTDNLFLHLAPSRSIWHTFFPVLRTPIELKISITRLEQLWSRHKALNDQDHALLSRLSTLDARELYLSYGPFPLLHCTWCSSTSSLDYMLVLLPSIALKYLLIATIDSILLMGSQGRRKRWRVYVVGALGAGFAGEVYARWSNVGSGKVMMIDSLLHLLIPSLLWIPTVLTSYFLPPSPIQPTTPALLQPHLQNLLSLSQTSLCSIRSTHLHKMALMTHSETRELVHGFWEGQERELRWAKGDKVLKEVLRGVEIGEEERRGLGLGKEDRDGMRKVFGIGGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MEE0</accession>
    <name>A0A2X0MEE0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C015g07772 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C015g07772</name>
        <name evidence="1" type="ORF">BQ5605_C015G07772</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MEE0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY17400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="166" mass="17949" checksum="3025E78983801E0D" modified="2018-09-12" version="1">MYQHTVVSAAPACGVHVPIRSHVQALWSPGRAIATSPSLGREDSAVPWASSSARCWAPRGSTLLFVPLRSTESASRAARIALKPLKPRVSIRDNLGPQTAVCTHPLQARHWECERSKSTGHLSTCCSQGKVQLPPPPQPNPEYWNLLEGSDSGQLLRPTTSVCIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MEJ0</accession>
    <name>A0A2X0MEJ0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C005g03611 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C005g03611</name>
        <name evidence="2" type="ORF">BQ5605_C005G03611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MEJ0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY77342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="417" mass="45801" checksum="8FF6BF014B1DC0D8" modified="2018-09-12" version="1">MSSSNSETIDWRGRAEQAERALVLQQLESERDLACAQRDVLQARVAALETANESIRGRNEYLENRDRIKVEHGQCYGGLSSRKPLANLLQHSLNRLLSLFKTTFRIADIKSSMSGASRRKRVLDTTQLSNNDNHAEHLSTDPTCLKLQNELQGYVRQEAIKDHLHFMKLEDGKDDPEVNINTTALREVKIEAAHVAMAKIEQRSNGAVTLLWPAVTTTIAELATSSIFKAGIAFGSQNENRVRLAVDIIESRYPALQMWPPTSPVVKQLLATKIANVAKTSSTRATKRRKSSNDNVTASDSVSAKSLEVVGDGTMTRNHDKAPSIMGSDATTSQVLDCESPNHTASEIGSPSPHSETGLESILAAQHVVIASNVSSTSRHAVLVRSRGTLISKMCRSPSMHQTRREPIIATESEVIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MEQ1</accession>
    <name>A0A2X0MEQ1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C005g03671 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C005g03671</name>
        <name evidence="2" type="ORF">BQ5605_C005G03671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MEQ1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY77571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="194" mass="21083" checksum="F20A4D86ABC09376" modified="2018-09-12" version="1">MGIGTYRDAREAIDWFRKAAGHGDKRAIDRLRMTGATVETMYGRPPPQALELPQAAEPAGNYKPPIETKMKNRTLGNRFGVGKREGLSIHTGGRSASAGQALSAVESRGKPSAREFDNALRAVRNAGRLEFPRQRSVSQPSTPTDAYQPHPRQRHDQQLDYSGTRPGGPPTPPKSQLGPPRLSAKALRLKLGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MEW7</accession>
    <name>A0A2X0MEW7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C008g04902 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C008g04902</name>
        <name evidence="5" type="ORF">BQ5605_C008G04902</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY78628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MEW7"/>
    <dbReference type="STRING" id="796604.A0A2X0MEW7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF4">
        <property type="entry name" value="FAD_NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY78628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="617" mass="68933" checksum="352F6276D9B648BD" modified="2018-09-12" version="1">MPLYSEQRPIRVTIVGGGISGIAQAIRIKERLGNKAKITVLEKADSAGGIWRDSKWPGAADGLRDGFMLMHGIGSQGVDVPIHLYSLYSDLKHDWTKLYAEQPEVLAYWLGLIEKHGLDDTFSYNSEFVGSTWSHSSQSHTLEVRDTQLEQIWSFETDVLIGANGPLSTPLIPKIPGLDKFKGHYFHNLRWDEGYSFEGKKIAVVGSGSSAIQFIVSRLTEAMLRTDSSNHLICRVQQPGLAALPGVHLTQFIRSGGYFVPKINMPYSHLVQLAFRWIPGFQRLYRFNLFLESNDRWRARNEEAVRPTPTETSLIKYLADTAPAKYFEALKPDYPFGCKRPAFDHGWLKSLHRENVDLVNSHIVEFDERGIKTQDGRYFEADVVIFATGSNVAEHGVGINLGVKGEEGKTLNEHWKEIGGPQAYLGVASIDLSTRFSSQYPNLFNVIGPNAIAGSWGYTIGTMTKFISRLVSSLVENDLTSLQPTITAFRAHNLEMRSKLATSTMNSQLCSNWWRVGGKGLITVPNWQTGFGLAASVRKIKWDDWVAFERISPVEAVDVKQAIGEVRPVDVKKRFWFKTARKSVELGVILTAVVAVVRSQGVVDKLFDAARALFVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MGD3</accession>
    <name>A0A2X0MGD3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein YAE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein yae1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C008g05120</name>
        <name evidence="10" type="ORF">BQ5605_C008G05120</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YAE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MGD3"/>
    <dbReference type="STRING" id="796604.A0A2X0MGD3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019191">
        <property type="entry name" value="Essential_protein_Yae1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038881">
        <property type="entry name" value="Yae1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18829">
        <property type="entry name" value="PROTEIN YAE1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18829:SF0">
        <property type="entry name" value="PROTEIN YAE1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09811">
        <property type="entry name" value="Yae1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Essential protein Yae1 N-terminal" evidence="9">
        <location>
            <begin position="56"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY79394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="232" mass="25308" checksum="71F5928861D48C75" modified="2018-09-12" version="1">MMDNDDDSPWMQDDDIDFHHQPGSSTSAPSAHASRHEDRIAQQEYNKMAARYHDEGYRAGITSGKESSLQQGFDEGYSISAPLARQLGHLRGIATTLLAILTTNSGAKYSSPVLDHFSSAEEKERVVTALRDVVSCLGALSQEDVVPVDQEAEEHKKEHDGDAGENLKTIERNQINQLNAMMQGLGAGQESVPRSKPGLEECKQRLQIVLDACGMGSIPLHFSEGSVDGMTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MGM8</accession>
    <name>A0A2X0MGM8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C017g08489 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C017g08489</name>
        <name evidence="9" type="ORF">BQ5605_C017G08489</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY20142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MGM8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000019">
        <property type="entry name" value="DNA excision repair protein ERCC-6-like 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="640"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="1029"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="356"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="519"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1371"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="129"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="215"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="377"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="429"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="447"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="477"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="521"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY20142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1398" mass="157470" checksum="73C005C92F278EEA" modified="2018-09-12" version="1">MSAFRSTTMSVPGTVQRPTFQSTRTTKQIEQDQLSGHGRTFSQSRSTRTATHDGDLESSSMDEEETHLQRGTSSTPSISRTSQGESSTPPPPNGTRSSTPLTIPRPRPRMGTPEPDEEFDSGDSSDDPDFGREMREQAQREKEQAEKAQKALEVRQWNKEEKLRAKKQGRRPRLREMPKPLKKKIRGKGKQEEVIDDEDTYRRKVRNGKRKVIEQEEEPCSGEEGEDDDDDPRSRAKSTRPTFDPDAKAREVQKNWSNRLIEGKKAKEARIRAGMDITQAEIREHCSRKWVSRENPDQMTRKRYEMEKRYNPLFVMLDIAPIIVADKDMVENDSWDDDDEDGENAEDRVARKILAEHHAVEMDSDSDDGRSHRRGKRPEGVVRRLRRTDAERATPPVMETIQLSSNEEPDTEDDSMFIDQARKSGSKTLKLEALGDIKSEPGSEPVIESDSDSEPETEDDDDVPIPGSSARVLKTEGEEEEEEEEEEEKVDAFTAKFLEQQKRNELEKKQAWVAARLEAVTSSQSTRTESQTSTHAAPENPPKPAEVNASLEAEEEEAEVGEISLLESQRIIKDRRLAAETMSQSTTEEKRIVKGCRPRFDASPQQLEIGDHILSPRHRIPAPINRFLRHYQREGIEFLYKQYSAGMGGILGDDMGLGKTIQVIGFLSAVMGKSGTKKLDAEARKRKVNEWDGVDPPQPSDLGPTALIICPASVTENWYREIKTWSYLKVGIVGQGKKRTDDLLTMFRSGHLDVLISGYEHIKRQIDVYRALDFSIIIADEVHRAKSRSADTTASLHAFPTKLRYGLTGTAVQNRLGEFHTILDWACPGKLGTWQQWRDLVEKPLKFAQSSEADQTTLGRGRIRAWALVTGVLPHFFLRRTKHQPSVKLQLPEKTDNLVLCPLTPLQRQAYQNITATDEVQMILTADQPCPCGRKDSQGLHLKRGNCCNQDWSEHIFRYMHAFGKVSNHLALIYPNKDDSQKNPTKYELDVRILKAAFPEDWKGRSLGPGTALDESLCGKWKVSVLRRVLEELLDVWYEARDKVLIFSNSLRVLKLLEDLFQFSKFPSLTLTGETKQEERMARVDQFNDPNGEAFCFLISTKAGGVGLNLTAANKVVIFDPNFNPSHDLQAMDRSYRFGQTREVNVYRLIGAGTIEEIMINRQQMKRGLANVAYDAAPQPRLYTGIEGSKAHEGELFGVRNLLTLKTSSLTHRVVENAAMEDANFAKEEAEEEVVEGKGEEAEPWQGADEVVNEMMSKTTGEGEFPPFTLSRLATLCPYAQATANLSFGSDLHTGPKFKAKTEAELEIDRILSGLTTVNADSTLAPSKLEAQRGAKAMAKEIEERDRLAAQNRRAGKRSLGVEVVAFDDAGKNGLSMGRGPPPKVFDPFARAKKKKTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MGR2</accession>
    <name>A0A2X0MGR2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Diphthine--ammonia ligase</fullName>
            <ecNumber evidence="2">6.3.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Diphthamide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Diphthamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C017g08519</name>
        <name evidence="12" type="ORF">BQ5605_C017G08519</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>diphthine-[translation elongation factor 2] + NH4(+) + ATP = diphthamide-[translation elongation factor 2] + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19753"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10174"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16692"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.14"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.14" evidence="2"/>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY20193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MGR2"/>
    <dbReference type="STRING" id="796604.A0A2X0MGR2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017178">
        <property type="term" value="F:diphthine-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01994">
        <property type="entry name" value="AANH_PF0828-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000145">
        <property type="entry name" value="ATP-binding domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1490.10:FF:000001">
        <property type="entry name" value="Diphthine--ammonia ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1490.10">
        <property type="entry name" value="putative n-type atp pyrophosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002761">
        <property type="entry name" value="Diphthami_syn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030662">
        <property type="entry name" value="DPH6/MJ0570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00290">
        <property type="entry name" value="MJ0570_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196:SF2">
        <property type="entry name" value="DIPHTHINE--AMMONIA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION 71 DUF71 -CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01902">
        <property type="entry name" value="Diphthami_syn_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diphthamide synthase" evidence="11">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Diphthamide synthase" evidence="11">
        <location>
            <begin position="95"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="82"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="483"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="653"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="490"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="655"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY20193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="853" mass="94262" checksum="6425510458502DDD" modified="2018-09-12" version="1">MKVVALLSGGKDSIYNLLHCILNGHEPIAVASLGPGKGKDELDSYMYQTVAHSGLSLIAESLSLPFYTRIITGTAIHQANSYGSRTGQASSSASTLASESESGEDKDETEDMYELLRVVKEKEPTVQGVAVGAILSNYQRVRVEQVCSRLGLVPIAYLWDRNQTDLLGEMVRAGMESVLVKVAGAGLGVEHLGRSLKQMEPTLHRLNKKYELHVCGEGGEYETFTVDCPIYKSRIVLYVPFGSSLCSSFPGLTADRLYVCQCPPTSSKKTTTIISNSDPYSTIAHLHLDECILEPKPNHPQNETLEQLRARLRSLVTVPPMLDRSSLKIYGAVREAYRNSTALEILSLDARASESDRAKILTNSSPSSPTITTIGPWLHFSNLSHYSTNSSSTLPIESETTQLFKSLIQLLSQKSSTLLHLTHLNLYLSPKTMNLFPKINQVYSTYFGTAPPTRVCVGILFPSEEEELGSPRIKLEGIAYNHNQSHDTRTSTTPSPQLYSHSDPNSPLLEMNSEQTDRKNVHVQSISYWASANIGPYSQSVIVNGGKSIYLAGQIGLIPQSLELPLPTTITIEDEDRGFEKKKKEEVEGEEIFAVETSLSLQHLRRVLVVSIGKRGYSLGEGRGEGLGRSYGRRLEGARKGWRVGYGFLRRGGEEDALDENEDEEEEEDVVEEDGDEVDRVPLLFVSAEALPKGAKIEWQVCWESGVRDEQDDEGESEVEDDEGSSIIKEVGRTKWLERDPTTQSSDIVLKYSKTSPSSHLLTILVGGSMTCNFSRARRDLPSSSEAGLLSLKVLHKPGLTQEQIDRLVSDLLPDEVLSTPERPTTSFICCEHISTFERDDLDVAVFMNYVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHV4</accession>
    <name>A0A2X0MHV4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C031g10965 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C031g10965</name>
        <name evidence="5" type="ORF">BQ5605_C031G10965</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000068">
        <property type="protein sequence ID" value="SGZ06726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHV4"/>
    <dbReference type="STRING" id="796604.A0A2X0MHV4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003976">
        <property type="term" value="F:UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046835">
        <property type="term" value="P:carbohydrate phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047141">
        <property type="entry name" value="Stealth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031357">
        <property type="entry name" value="Stealth_CR3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24045">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24045:SF0">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-1-PHOSPHOTRANSFERASE SUBUNITS ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17102">
        <property type="entry name" value="Stealth_CR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Stealth protein CR3 conserved region 3" evidence="4">
        <location>
            <begin position="599"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="325"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGZ06726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="973" mass="107639" checksum="DC18C7A197A2E557" modified="2018-09-12" version="1">MYSSTQAPKSPPLAVTSMAVWAADPRLSMPSTASHDQRTPTSDCGTPRSACVSGSGLLSTPAASPHSFHDFSTTPDLEKGLCSPSYFHAHGRGGSPLYHHSTPSSSEEDLSSGSAKIPLLVHLSGLRGLASGSPKLSSTWSIRLIQYVRSRIARCARFVVVAFAISLMIFTFQSRVRQLVAPETWKFGDSLLSDLHFGFDQSPAELKEARESVAEFLSIPCINDGVVPFSPNLYDPLLPPRPYQKTVAQKAFSSVCADIWVSTGELCQSAEEQWADQPLQMDALWTWVNGSSEDPSAAWRAKVSDEIGFGTGTKVVPAKPILAAPAPPHPMSQSITGAPDRARGSRLPAEQPGAPERFSRAKRALGATVVRHFREHDELRHSIRSVVASFGARTLKQLHLVVNDEPSLTPDGEKILIGDYPNSTILSQVPQWVNLERVQLSGVEPSPNATFFDSRNDGPVLKLHPHTSLFKKTIAPSSLKNTAKGFRARQAAALKWRESVTPNFNSLAVESQLANVPEDTSDTLLALCDDFFTMRPMTLSDVESPLTGPVIRMQRDLIVESSPPDHLKGDAEGEWRGLGFTNWLLDQRFGARPRPYLLHVAKAISVPMLREVQSVFMEEMTATAGARFRGKAPYEMQLWFLLHHYTIEKHREALLWSFFVARSDSDQDDRYSLAERLALMSELDVEPAAPASNATLPYTVATPFRHTLAVQMQPEHDYTGLPRALESRYSFSSKDGYALFKPAPNSILPSTMAEDWPRFDQRHSAQLDEDLGVPPRSSACTIGDLSVCFPKDFLDPENNSKMSVDETFRRLAFEQPKCGDCFIVQLLAKSGELGLNKFLPDAVKQDEEDAGIPVEVIGGAEKKWHDVTSFRGDLKGFTQRQRAVSLIQRYSYTIADTSTRFHSMRFPSALMRDLAALSRIRPALIALNDDVSGETSTIDDILETWFKKEFPVPTIWEMEEEQEPSDQVTNLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIA2</accession>
    <name>A0A2X0MIA2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C011g06447</name>
        <name evidence="14" type="ORF">BQ5605_C011G06447</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIA2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000007">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="12">
        <location>
            <begin position="349"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="13">
        <location>
            <begin position="891"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="11">
        <location>
            <begin position="1203"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGY12267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1255" mass="140448" checksum="CCE008BE22786790" modified="2018-09-12" version="1">MPMPTAPSHSPTYSRPAAASAAPHVATAATGHSPITGGPRPVARLTVDERAYLDQNHGCYRCRTLNADHISRNCPRYLSPMGASATPSTPTSTAPAPRPGPRMVAAIRTFQETGDSTVFAGLSSDSEDDNDPSYAPHPFPPLPVSLAGAHGTLLASALVDSGSPQTFLSEELVQRLGLERRALEQHSKYTLAMQNQVPTVFTCTHFVRVPLELANGLWAAGPTYAKVAPLGKDLAIILGGNFIYRHKMELGLFPQPHLTCKANPIHAIDLLALSSQPCAATRVAAIAPVSDDEEQLRLAALDHRLRAEFADRFPADIPPVHLYQSPVRHRYPLPKKYCEAWYLLLQEHLAAGRLRPSRSAYSSPSFIIPKKGCDVDPTIAPRWVNDYRELNKHTIKDRMPLPLPDNILSTCSNAPFWAKIDMTNSFFQTKMAEEDIHKTAVSTPWGLYEWTVMPMGLCNAPATHQRRVNEALQGLLGTICFVYLDDITIFADTLEEHEARVRQVLDALRRAELYCSPTKTNLATAECSFLGHIINRAGVHTDPKKIQRIEYWSLPKTVKELRGFLGLVQYLRKFIPGLAEHTAALTPLTRQGLSSIATLWTPNEVRHFKAIKAIVTSLDCLRPPDHSANAAPFWVMTDASNHGTGGVLLQGQEWKMARPIAYWSRQYIPAERNYPTHEQELLAIVEALKEWRIDLLGGHFHILTDHSTLERFQTQRTVLSRRQARWLDTLAKFDYDLRYLPGEDNIVANAMSRYSFTDPLPTLVAAVSHVKLSDAVKQQILDVYETDPFCQQAMSNIGSVTSDFKIVDALLYLRGRLIIPSLAPLRESILHDAHDAQGHLGDMKTYQTVQQAYFWPNMSRDVKHYVQQCDSCQRTKARTTRIAGKLHSLPVPTRPMADIAIDFVGPLPANKGFDRVLTITDRLSGYVRLLPAREADTAAEVAARFHEGWHRLFGLPQSIVSDRDKLFTSKFWTALHKRLNIKLQLSSAFHPETDGRSEKTNKTAFQILQALVNKEQSNWAECLAVCEYAINLSLNVATGKTPFELVLGYTPSLAPLARVDGDDDLPSVEELLALRFQACKDARDQLAISKVRQAAQSNKKRQDEPSWAVGDFVLLDSSDRQKRLHTRKRRAAKLMDRFDGPYCIVKAQPEISSYTLQLNGDDAAVPFFHTGKLKTYRKNDTALFPNREPARLGPVDVGGEPEYIIEDIVDERIRAGKQQYLVSWLSWPSDSNSWEPAEALEDTEALDRWERRNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIK3</accession>
    <name>A0A2X0MIK3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">H/ACA ribonucleoprotein complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Nucleolar protein family A member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C018g08702</name>
        <name evidence="9" type="ORF">BQ5605_C018G08702</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Common component of the spliceosome and rRNA processing machinery.</text>
    </comment>
    <comment type="function">
        <text evidence="6">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
            <location evidence="1 6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY26126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIK3"/>
    <dbReference type="STRING" id="796604.A0A2X0MIK3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002415">
        <property type="entry name" value="H/ACA_rnp_Nhp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00883">
        <property type="entry name" value="NUCLEARHMG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="8">
        <location>
            <begin position="81"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="20"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="171"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY26126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="210" mass="22527" checksum="9495B2F8D072643E" modified="2018-09-12" version="1">MGKRSAKVLEEGAVAAPAAGDVSMDVDAAASPRKSKKSKKDKESSKESSKESSKDDDKEVAVELLSPIARPLAQKKAGKHVLKLVKKASKSRHLKRGVKEVVKSIRKGEKGIVVLAADISPLDILTHLPLLAEEASCPYVWVTSKEALGAASSTKRPTSCVMVAKLGMKKKVKAGESEKEGAKEAEAEFQESYGEVETEVKQLDETVPLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIL6</accession>
    <name>A0A2X0MIL6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C028g10462 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C028g10462</name>
        <name evidence="8" type="ORF">BQ5605_C028G10462</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000080">
        <property type="protein sequence ID" value="SGZ11853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIL6"/>
    <dbReference type="STRING" id="796604.A0A2X0MIL6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF7">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="7">
        <location>
            <begin position="67"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="6">
        <location>
            <begin position="177"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGZ11853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="327" mass="34981" checksum="AFF089F63F40FD56" modified="2018-09-12" version="1">MRSPLAAFLSSDYSARLIARSSHVVPPLVLVHHIPRRHALLLALVDFFANLVERKVASLRLFTGTEHGHVVVKVEACGICHSDSIVVNRAMPTGLPRIPGHEIIGCPRTRKSSKWAIESVVDGTEDIVAMGLTPNAPFQCLSCRRGDFVTCANQAINGISVDGGYADDAAESAALLCAGGYKTVALSQNVSKAQLAKELGADIYLDASKVDQIEELNKLGGAKVIIAVAPSGKAMAELIPALSVGSQLVLLAVPHDGLTVNAMHLIQKRRSIVGWPSGTAQDSEETIAFAEHAGVKTSIEKFSLDQVQEGFDRMSENKVRFRAVLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIT4</accession>
    <name>A0A2X0MIT4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C018g08782 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C018g08782</name>
        <name evidence="1" type="ORF">BQ5605_C018G08782</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY26773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIT4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY26773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="295" mass="34495" checksum="B336491C0EB91481" modified="2018-09-12" version="1">MGKIDIESRESWRSLVAATRDFSPWGFFSSTARLEKLYRDSTRWGAVVAAARVTLPTIKSELLTLPELLSFAQIADLYWRDKGKGWALVGHRRGFWQHSKEPALQHEHVWSRVGQLLKAKALLPKTTLRPARIPLKEAPRREDHIKCFRDGTSQSDRKRFWRWLHDRFASAVEQDTHWWLMYNVTPKRKRQHTQGHASLLTCLFCGNNAAVIETVSHYFFECAYSTSFWGGVLRILFDKLGIEDTNVDPSTTTSKWMWVRLACAIGFQQLHLLRWRVHQRFELDKVPCLPLRWAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKF1</accession>
    <name>A0A2X0MKF1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">BQ5605_C033g11174 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">BQ5605_C033g11174</name>
        <name evidence="17" type="ORF">BQ5605_C033G11174</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000066">
        <property type="protein sequence ID" value="SGZ01935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MKF1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="16">
        <location>
            <begin position="114"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="SGZ01935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="892" mass="100218" checksum="3203FAF460653870" modified="2018-09-12" version="1">MPGMPVGLLSVQQMTNSGLSVHFEPDKLCTILRNGEFIASTIVLDGPYELDIKQPKLALATHETVSAPLMLWHRRFGHPSPQTIINMARSGAVQGLVLSDKLIRDCLHCVLAKSKRSPFTIKATIATEILKRVCIDLGFVPEPDHQGRTVYLAIVDQHSCGRWVFPLSSKLSEGVIEAFNMFRTSVENMTGKKIRFVRSDNGGEFTSKMFETYFKTNGIIHERTAPYTPENNGQVERLNGSIMTTVKAMLHDANLPKTFWSYAMQAAVYLSNRTTVACLNRVTPYKIIFGKKPRVSHIKPFGAVAFVHIDGTLRTKLDDKAVEGILVGFNNYDYVVWLKDQQKEVRTRHATFGRRKHHLLETSELVTDFEVPPISEISEKDSTVTPAEKEVPQQLVPVPDGYIQVQNGYQPGKYGELDMSNIIPYKHRQALFAGPALDSSSSNLQFIRIDDVLPQIDGKWGKTYLCVSVPQGHFIPKTYEEAIPCPDAKFWIIAIREELGALENHNVFEVSFLPDGAIALGSRWVFTIKLDAAGRIIHFKDRLVAQGFAQRPGIDFHETFAPVARMLTIRFLVALAIARSLKLVQFDFDTAFLNGKMTDDVYMRVPKGWTGVIKPGQCLKLIASMYGTKQAPREWNRTLDQLMVEKKWTKCLSDVCLYFKQVGSKYIIVAFYVDDGLFKRDAGYCIVHQSRYITDILARFGFASSKPKTTPMIDCEARELDSLPLIKDVHLYQSMVAYSDASWANNFETRRSVGAYVRLLGGAAISWQSKQQTLVATSTTESEILAVLSATKEVIWLHQVAKDLSVEQPSATTIYEDNQATIKITYNPAHHARTKHFDVVHHFVRERVTLGDIKLVYCPTNSMMANVLTKGLGPIKFAAHRKAMGMVQLSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKM7</accession>
    <name>A0A2X0MKM7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">BQ5605_C032g11019 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">BQ5605_C032g11019</name>
        <name evidence="18" type="ORF">BQ5605_C032G11019</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000067">
        <property type="protein sequence ID" value="SGZ03766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="17">
        <location>
            <begin position="488"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="769"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="18"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="824"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="861"/>
            <end position="872"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="SGZ03766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1442" mass="157443" checksum="E4C29BB2836C4C17" modified="2018-09-12" version="1">MRSRGSAEYSESAGKTEGDDEAADDGEDAGDGAGDGDEDGAGDGDEDGAGDGDEGDSASVELSKVPPVYPGATSTALMEDVRAPDFGWADLGPAKWPHSGFSPAQATSWSGLPWLLAQPSYQCGHLRARPSLYFFTLRNMSDAGASAPEAKLREPKPDAPPLRPPTHSVAFATTELLRNSSGYRDWVLAIRSRLPSGVVRYLNTGVPLESWPASYVPLWDHYACSSICASVDSQTVLPGLSPYLNESLAAPKVWQALRERYGTVSAVDLLPVIQRLFSSDPVPVTPDLFLQFRDSFENDARLLQDSRVTVNALLASHLLARLPSSFDAWRTTFVAAQGDSTAMPSATEIFTRLYRDVKARPVDTPVAAVATPQARHGCSRPCPNPSCRKLHWLRECPDTAWAAAYRARRTAEKKASQPVASPTPCTPKALLAVPANVSLLTLHRRLAHLPVAQIKNIVQSGLVTGVDWVYKDQELRDFYCNACLASKAHALPFARSKSIASGRLDLLHVDVAQMPRPTFGGHRYMLVIIDDFSRKHWCILLALKSDVFPRLRDWILEVENATGNKVKTIRSDNGGEFTLRNFVDFCASKGIRRELTIPYTPQQNGRVERSNRTIKEGILALLYSSGADSRLWGEAALYYVHCKNLMPHAGIGGEIPDTRWHGFAPDISTLRAFGCRAWHHLPSAKRTDLDPKAVPLLFVGFDQHAKAFRLFEPSTRRIQLSRNVVFRESEFPALRPATDVRAEPIPLPVTVDAYPDQVDPLEPSLVASPRSLAPRAEPPRPVPAAPDQGPHRPAPAREVPDQDSLAPPAPDQGSPARELPDPESPASSASDQGSSDSAISTPCPSPRPVASRALPAPPSPARSDSPDPIDLLPRPRDVASLCQAQGFPDDVDDALHSPSAVAYLASGAAALIETSPVDPAELIAPARDPPHWRAAMATPQADEWRLAARDEFDSLLRDFSAFTPIDESLVPADAKVLGSRFVFRTKRDQHGQVKSYKGRLVARGDSQRSGIDFDETFAPVAKFTSIRALLALAAAHGYHVHQADIDKAYLHGKLDAPLYIRVPDGIYMPGKVLQLHRSLYGLRQAGRIWNDEIDSALSALGYVATGSDHCVYVRTTGDVHHYIALYVDDLLMISPSLPEIERTLQGLEQRYGVKRLGEAEYVLGIQIRRSPDGSISLSQEQYLKDVLARFGMSDAHPVATPMPPDLRLEVELQPTPFPDRTRYLQAIGSLMYASTGTRPDLAYTVGYLARFSHSPSAAAWGAVKHAFRYLAGTLSHGLRYARGNPAPLLGYSDCNWGACVLSSKSTMGYTFVYAGAAVSWSSRLQSRVADSTCDAEYLALSHAGKEAIFLRQLFGELGLSSSKPVLIYGDNQGANALTKNPVFHARTRHIRLREHFVRDMVSMGDIVVQYINTGEMTADIFTKALSRDLFARHRGRLGICAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLT9</accession>
    <name>A0A2X0MLT9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C024g09868 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C024g09868</name>
        <name evidence="1" type="ORF">BQ5605_C024G09868</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ26246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MLT9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ26246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="46" mass="5184" checksum="6CB50B7AB3898D80" modified="2018-09-12" version="1">MGGQGSPREKAERLVLGHDLTADFQQGDMELTPRLIFNMSTHRIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLV3</accession>
    <name>A0A2X0MLV3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C012g06899 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C012g06899</name>
        <name evidence="2" type="ORF">BQ5605_C012G06899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MLV3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY16541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="303" mass="32144" checksum="2DA7FE4843B7EBD6" modified="2018-09-12" version="1">MSSPAPPPPPLPPHGTPPSGRCNRSTSYVDCSPSSSKSRSSSSSSITAVSSSGGGGGKALERSKTWERRDPLRDITNTYFDVPFELMTTESRRDGRLHRVPTPSSVDPLLTPSTSLADAALPSPFSSLGRPLRSTRWLRRSVTLGATPSTAFTSSSFSSPVTPTSTGLPPRPTPPSASDEALPSSPTRLVRSSSRRRSHPPDEASSRFELRSTSRQGTSPSASRSGGPVIEPLSEEPDAADLNENEAFPTAPSLRRTASSSSVASASSTMTLSDTSSLSSSLSARRLRRRTSQSESENRGRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MMZ2</accession>
    <name>A0A2X0MMZ2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C015g07944 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C015g07944</name>
        <name evidence="2" type="ORF">BQ5605_C015G07944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MMZ2"/>
    <dbReference type="STRING" id="796604.A0A2X0MMZ2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY17985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="506" mass="57181" checksum="3E82FB0FE3C06795" modified="2018-09-12" version="1">MASDGPYPSPAASVRTFPSHPHDHRHDRHDRHDHHDRQLPNAYQPSPIGPSLSLSLSLPRPSPSSSTYPTSLRPSLLIPRRTCLAPALSTPSTSLDVRPIHVSSIQPTLFNVNPSRLGQGRNPFDLLTEHKFDRFVENVTETIKNVLRRPDAVGPETTKTMTGRRRDVFGAVERIGQQGIPGNDDAEQDDQRGVASPPLTENRPLFLHETSEEYETSSEAPRHSFDPILGEQDQAQPRQNGETEVIELGSSSDEQDEDEEEEEEEQDGSYDEDSVDDARSGSGQVAEDEWMNEAPRQSQFERHLGSEGSRSIQRGREVDLEEEDEEDGEEDDDKEEDEEDGEEDEEEEEDGDDEEDEEEEARDELRDDEMEQHVQEQDQEEDEEELLDPQTAFALSMQQITRVDAQGDEVDTFVEILEEEFEVNAVDDDGKVFQPVDDEDEDVEDEQVDDDEEGTPPLPPSMAEAFRNARSGEVWDPMIKGPSLLVQEPEYNDDDAEDEEVCHERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNU8</accession>
    <name>A0A2X0MNU8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C020g09217 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C020g09217</name>
        <name evidence="3" type="ORF">BQ5605_C020G09217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000082">
        <property type="protein sequence ID" value="SGZ18989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MNU8"/>
    <dbReference type="STRING" id="796604.A0A2X0MNU8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990862">
        <property type="term" value="C:nuclear membrane complex Bqt3-Bqt4"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070197">
        <property type="term" value="P:meiotic attachment of telomere to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044820">
        <property type="term" value="P:mitotic telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037548">
        <property type="entry name" value="Bqt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38044">
        <property type="entry name" value="BOUQUET FORMATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38044:SF1">
        <property type="entry name" value="BOUQUET FORMATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="2">
        <location>
            <begin position="130"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ18989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="472" mass="49185" checksum="56149F3FDAEE659E" modified="2018-09-12" version="1">MAQKSSSSAATPAPRRSSRASTPTARALSPGSTPPPVPSIASTLAPPSASGRKPSSSSSASVRGLSPKPRSKAASGTPSGQAKSPASAKSPVSTSAKTRPPLPLSDKNDLLLESKAKLHKVKTQTLHLGPPTNDSIVIARVKCPVPKGVPGHLIKRFDTNAISASSFFRAAFPTASVAAESAEMKYIVAHPRQFGNTKVAGREDDEAHRLSGTWIPCDKALALAEEYGLTKFATDLVNFVSSEQNATSDAAADQSEADILLLFIPQSPALRSPRSKRARVQSPRATAASPTPKSALSGSSANGVSILQTLSTDAKTGVTTETTEVKVDVPVSDAAEASSNGLVASDEAVAAQIAQAKQLVEDLKASGTLAKLTQDTTIPSSSVAKRTHEEDEDELPQTGTLADALRDDRGFFGKLFRRRPNGGRRVPVNAGREIRPAPAQLALVQREEAEGRRWVAGFGLALATAAAPYLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MP41</accession>
    <name>A0A2X0MP41_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C023g09742 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C023g09742</name>
        <name evidence="1" type="ORF">BQ5605_C023G09742</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ24727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MP41"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ24727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="503" mass="54303" checksum="53AC1F1AC5B3C8C9" modified="2018-09-12" version="1">MSSHTMHVASPPSFSSSIESVEEPPIWTFTAKFEHLIAEFGSTVEDWESACAVAPDLKQRTLDQLADKGRRVIQSFCNGCSALGHDQVPQEPQELAENVVPKTPNAQTPPADSEPSSYDHRHIALELDETPSQASAQSLLSSPQSFLDDILVDDVRTAIVPSSQDEATSVAFTSLTAALRSLSPSLTIPSLPQHAALTLPTPHSVNSFSTITTVSGTNAETVYVLLMMKPSPKFPSRKDGREQLCPLVLVSNISAHSQEGTARDLLVLAYEPNSKEDELPTELLTVVKDSPTMMTLAPDGTVVDNDAADTIVFGFPPGSIVLTRTNEEEKGTVGKSRGAAAGTLDSRLASTLEGKGFIEQTPFLPTIRKLEVGSTPWWRSQICRGDVGPIQASPIHAACNGLKLSCLPRQHGRSSSTPGYWQGNARNVRRNRILRHFATCKQGIVAPELTAFAIACLKAAGPAKKATVHRTFQFSLLPFKITETDDWPTTMNPLGDQQHVLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MP66</accession>
    <name>A0A2X0MP66_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C021g09338 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C021g09338</name>
        <name evidence="2" type="ORF">BQ5605_C021G09338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000083">
        <property type="protein sequence ID" value="SGZ21162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MP66"/>
    <dbReference type="STRING" id="796604.A0A2X0MP66"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000030">
        <property type="entry name" value="NAD binding Rossmann fold oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF6">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="108"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ21162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="427" mass="46671" checksum="7B5D4AF129FF114A" modified="2018-09-12" version="1">MVASPVAPLQVAMIGSGEYTTGLTANNAKSDKKIGVVGLTLFDLRRRGIVDKLSIAGTSDKWAQVDEHFAKNITGAYKASRAFLGEELVPSVLIPCSSRDPDAYKTAIDALPKGAAITIFTPDSTHHDIALYAIQRGIHVLVTKPACQKLADHIDLINAAKKAGVFVMVEHHKRFDPSYADGKFKATLIGAPNYFSSYMSQPKTQLETFKAWAGRDSDISYYLNSHHIDVHCWYMEGVEGDWAPVKVTASGSGGVATSAPFNCVAGTEDTITLLVEWVSQKDKTQRCTGVYTSSWTAPIGAGVHSEQYFHYMAAKGEIRVNQARRGYNVVTDAEGTKDYNPWYMNYAPDGEGLFQGQHGYGYISIEKFVTACQRVNAGTVDLEHLDRTLPTIKATVLTGAILEAGRRSLDEKRSIEVVHKDGEWGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MP82</accession>
    <name>A0A2X0MP82_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C024g09784 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C024g09784</name>
        <name evidence="6" type="ORF">BQ5605_C024G09784</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ25859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MP82"/>
    <dbReference type="STRING" id="796604.A0A2X0MP82"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14868">
        <property type="entry name" value="uS7_Mitochondria_Fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047988">
        <property type="entry name" value="Ribosomal_uS7m_fungi"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="5">
        <location>
            <begin position="91"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="42"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGZ25859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="232" mass="25037" checksum="F645BEEB661AA57E" modified="2018-09-12" version="1">MSQRLFLRALGAPTPLKRNISTTPCAYSAYSAFGDALASSSSSSLLRPLSPSTSRSSPSSSTERTTKSSAPTSTFPALTRTSLPPPPPSAKPSVETELLGYLARLIMQSGKLERAHSHIALMLAQIQTATHSPPLPVLQKALQIVEPSIRIVGRKKGTKSLPTPQPLTEKQRTRQAWKWIVESSDKRQGIEKQFGKRLALEVLAVLGGQSEAIKKKEAKHQQGVVGRANVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MRS8</accession>
    <name>A0A2X0MRS8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C055g12642 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C055g12642</name>
        <name evidence="25" type="ORF">BQ5605_C055G12642</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000092">
        <property type="protein sequence ID" value="SGZ29182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MRS8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="399"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="141"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="671"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGZ29182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1262" mass="141249" checksum="86D8E55F9EE2AD5A" modified="2018-09-12" version="1">MVKSKSLSAKNIWEKLKQHHEGNADPFKIRTLLYEISNASYNEDTNLGEFLQASRTRSINSKISAKSSRMKPSSPIKLSDKCSVDYAVNRLTDEYSERKLTGKYDKLLKNTGALAVREGTQVKRDPNCICRGCKGTGHYQIDPECPKYDPNAKRGRNKNHSNKKKKQHKHSKGSADSEESASFALVVKSLEESHSLHINVANRVSQNDQSEIWILDTGASQHYVGNASLLTDRQHGSLNVQTASGQVVHCDTYGTVRFKLRSGASLSLSNVYHLPGAPVNLVSTRALYRSGASCGWEDGRDVMTIKIKGLTVAKTLNGTGYTLDFTRIVEDQAHVATRATVGAPLMEWHRRYSHIAVSSLKELVKSGAVDGLVLTDEKVHDCEPCISSKSRVSKFSESVTHVTDVLQRVFMDIGFVAEDQVDFQGRKAYLAIVDQYSTAKWTFPLKTKSAKEVTCVWIAFRQGVKKMTGRKIKRVRTDNGNEFTNKLIGTDFQSQGILHETSAPYTPQQNGTAEHFQWLLSWKYWSYAMEYATFVANRVLHSKLDGKTAYEVFYGKKPKVSHFRPFGSTVFAQVPKSKRSKLEPTSVRGTFIGYDNEYNYRVLVDSHSEHKVVITRDIAVLNLQPEEVRAPEVTTLLKGPDEDVGPVLEGNDARDELQDEVAVEQIAPARPNRPRWEYGDPAVRGQNPGRFEEIDAGNEIHQRTRGQRRIAEQQGLFVTDIPKLDPEPPIMSGYAMISTDRPAVPSSYEEAMNNVKADKWKEAIQDELNAMDHHQVLADSDLPHGARALGSKWVFARKENAQGEVIRYKARLVAQGFAQRSGIDYNETFAPVARSTTILFLIAIAASQGLCLEQFCCEFDSLALLSGAEMRCDNTPKSGPQSCKINLSTRAPSFRLHHSYDKFDYDSAFLNGTMTEMVYMKYPKGWDRPQLGQVLRLVKSMYGTKQAPREWNSAVNKLMVACGYSRSDADSCLYVKRFEEMFIYITLYVDDGLAASNDQTFLDSEIQAFNKVYQLKRLGPVKVFLGLEFLRSSKFIFVHQSKYIRSLVATYGGDHGSKHPAKVPMEPRLNMEHSAELFNDIALYQSAVGALQYAAHRARPDIVTSVRAAASKVSAPTQADWIAVKRIIRYLQGTIDWGLKYNLEGSTVFELYSDASWGDNMLTGKSIGAFPESTLLWEDNQAVIAIAQNPAHHGRTKHYSVHHFYIRERVTTGDIRIKYCKTGAMTADLLTKPLARNLFELHRDGLGMVSLGALTSGSVVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MTL3</accession>
    <name>A0A2X0MTL3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C040g11896 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C040g11896</name>
        <name evidence="2" type="ORF">BQ5605_C040G11896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000118">
        <property type="protein sequence ID" value="SGZ32639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MTL3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ32639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="393" mass="44652" checksum="04EC4AD7DF76CF9E" modified="2018-09-12" version="1">MLPACNPGCWMAPGLGQLANEIDLLLGSYFEGHPDYKPRGLRSDARIRTNIPGTRHMVTYTARQIQQRTFDEHARGEASLPSPRPTMAPPIQADFDEAANPSAMDWDDERHSEYGGGHERDFIESFEPATRGQSKKETYKQFVFNDARLRNLERPALLRQYIAATVLKEYRTRIQDFDDILARIFTVPVDIAAEYEESRLFREILSPLYQECQRPLPEDEIRTDEDQEGSDRLFKMDPKGVPPFSRETCPGRVLGSVRKRTSHLASSAQTICNDGACQEYNIRSERSGQLVLVHVPEPPKPPIDADREPERKKIWDSWIVECAHRWLALLSKQRETYRWMRKREEDAISEHSSATGQHSDHGSAAGSEAKSNLSALSELTSLSKLERGLDTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MTY7</accession>
    <name>A0A2X0MTY7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C043g12081 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C043g12081</name>
        <name evidence="1" type="ORF">BQ5605_C043G12081</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000117">
        <property type="protein sequence ID" value="SGZ32118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MTY7"/>
    <dbReference type="STRING" id="796604.A0A2X0MTY7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ32118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="446" mass="49436" checksum="6D45E0807F23AA68" modified="2018-09-12" version="1">MTTMQPILALRHVYEPAASAPGSNRAQTPQAHVSIRDDLGPQTASTRHCSACCSQGKVRLPPPPQPNLEYRQLLQGSDSEAVAFRENARSYNNALSFTSLAALWDQTQVGTLGPPVFRVFGRLYHRLGALIPAVTQRPTFAQTWLIDPAEATDTRLGPDSADSRMQRSTLTKLESILRTGNRFVREFASAKARAGWDTAKEWILRLCLPPGRDRRTHNLPTSSTEMAMLICDSDTNMGDPRSIRLRCLSGSHYYFLQGKMASTPTFLFAGFAKLGCQSPETESRSTMVSNRARYLRVSVLMTEAKSRTKTATMRMKTARKGTKRMVMVNDKGPVKGSRWRVSRSQFFAHYLPKATSTSQSRIAPTVPSWRCDGVCCQRGKASAADHDDVRPRLTGNQGCTGADSACNRPDLIARVFEAKSGNKRHAGCFGDECKMNRFCFFAVLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MU45</accession>
    <name>A0A2X0MU45_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C040g11855 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C040g11855</name>
        <name evidence="1" type="ORF">BQ5605_C040G11855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000118">
        <property type="protein sequence ID" value="SGZ32325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MU45"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ32325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="61" mass="7133" checksum="056E72F3C31A336F" modified="2018-09-12" version="1">MYQHTVVSAAPACGHVPLRSHVQALWRIYVFFVPVERSYSVPIIFLHFFVDVKQCLHLYCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MXQ4</accession>
    <name>A0A2X0MXQ4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00434 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00434</name>
        <name evidence="2" type="ORF">BQ5605_C001G00434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY46439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MXQ4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY46439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="120" mass="13171" checksum="71805D378F72BE8C" modified="2018-09-12" version="1">MEYTATPANSFANKLKRYGDSHAEDAANAHLAGGYKRNGGFDHQAFLFDTVTAKMKRHSGIRTAPQNTLGDHTLQAVCSEVIEDPVNNLSFSSRVADAVQEMGENSGKARKKKRTEDSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MY26</accession>
    <name>A0A2X0MY26_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C001g00554 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C001g00554</name>
        <name evidence="3" type="ORF">BQ5605_C001G00554</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY47650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MY26"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY47650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="180" mass="20457" checksum="AABD700504BBBD16" modified="2018-09-12" version="1">MAPPCGSTPVASQDLDDEDPSLNLTLADAFKPKLERRQQRRDQLAQQIAPLARAHKNEVNAILDKMKAELQGEKDAFEERERRFGEEEKRLKGELMRLSERMQEDMSASIGRVHQILADDEKYMAQFAANIQTIVKAEQEEVERRVQECWFVQADPQAEGAGLQTGDRQRKNTPAPARGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MYI5</accession>
    <name>A0A2X0MYI5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C005g03714 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C005g03714</name>
        <name evidence="25" type="ORF">BQ5605_C005G03714</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="521"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="816"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGY77742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1420" mass="156210" checksum="B42FB2DED7AEC899" modified="2018-09-12" version="1">MDDTSPPLATGVHPTFPADQLAALTSLLSGLTAAASGTVTTTTSSSTTRPAFPKHARLDGPKTFANWTRQLRLCLADDIRSYVLDGIVPVDWTPSQRSARELLANSIDSAEVSAVLDAIPTADLTAPKIYSTLKSRYAPDDATRTLELFSRLWSFRPMPGTVGEFDGWIMEFKAIAQEIIDTKTTINDVLATLLLAIAHPSLESFKASFTDEQRTQRSLPAIDSLADRMRVQLRSTNVPSTQSALLASSSSRPTRPKCLACHSPSHRVAECPVRAKHPPPGPCRSCKQNHWSFDCKKALENGKKADTANSTANSQHHVGCIATGFLARRRQLRTNSFVVDSGATSHMVSDKSLFTTYRHIAPTKIGGIAGGINAIGTGNIAFVAASGHPITLNGVLHTPGLFVNLLSVSRLCDTDDVRVAFTKHGIDIDKNGHNIAEGTRLDEGLYLLDADHSKCQHLALLSRSQSSVPLLTLHRCLGHLAPSSIQKMVAAGLLEGLGAGYSDEEVEKFVCNACLSAKGHRLPFPDSDSHSSERLGLVHSDVLSLPERSLTGKRYLVTFLDDYLRKLWAYAIGHKSEVFSVFKTWLAEVELETGATLKVLRTDNGGEYCSRAFTDFCKVRGTRRQYSIPRTPQQNGRAERVNRSIVEGILALLADAHLPKTFWEEAVAYFVYCKNLVQHSALDKATPNSVWQGGRTTASALHPFGCAAWLTVAPELRSKLDPKAVRVLFTGYDLASKAFRFYDTTTKKVTLGRNATFLDTEFPGLCGDSAEPDDDMHFASAPFADPQTTVKSWTPLYSADPLDLIGSQPQAALDPMDTQPPDFSTYREPASAEESPDELDLIGRHSRDESPDEIDFLTRHHRAFIATDDDTSDTEAIEPVKSITSDPQTWREAMSGDKREVWAKAAADEFNSMRDDFKVFTIDDRSTVPAGATIVSSKFVWKTKRNALGEITGHKARLVAQGNRQRDGIDFTETFAPVARFSSIRSLLALAATNGLHVHQADIDKAYLHGDLDHDIWMTAPRGFDLPGDKVLRLRRSIYGLKQAGRIWNRHIDASLRDLGYTATGTDHCVYSRLDDRQRPHYIALYVDDLLMISPDLAEIERVISGLEQRYGVKRLGPAEYILGIQIRRLDDGSIALSQERYIMDVLARFHFDTTTRGTTVPMTPGLSLTAIPGQATERIRSWYLQAIGSLLYISLGTRPDIAFAVSYLARFANNPGHRHWIAVKHIFRYLRATYRDELVYARGEARITGVVGYSDANWGACVDTSISTMGYVFYIAGSAVSWSSKRQSRVADSTTDAEYLALSHAGKEGIYLSQLLEELHVQPVAPAHIFTDNEAAAAVARDPVRVTGTRHIRLREHFVRDMVNRGDISLSHVGTSDMVADIFTKALGPKVFSTHCYALGLRTRHPRLGSASHSRGGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MZJ8</accession>
    <name>A0A2X0MZJ8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C006g03880 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C006g03880</name>
        <name evidence="6" type="ORF">BQ5605_C006G03880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY54452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MZJ8"/>
    <dbReference type="STRING" id="796604.A0A2X0MZJ8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12325">
        <property type="entry name" value="RRM1_hnRNPA_hnRNPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032:SF6">
        <property type="entry name" value="RNA-BINDING (RRM_RBD_RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032">
        <property type="entry name" value="RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="128"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="242"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY54452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="517" mass="54088" checksum="F6EF92C91FE8C0E3" modified="2018-09-12" version="1">MAAQEDETLARYDDLYDDLYGDNEQPDSKPVVLVGSTTATTSPGPALNTAPTGGVTASTPSASADMKPTFSASSGGPIQALQQHGQAIGIGMAMQAQNRAPAGVSNPMMGQPQQAQHNNHRPDPTEEGKMFIGGLNWDTNEESLRTYFSQFGPIIQSNIMRDQETGRSRGFAFLTYETTAAVDKVLAHGEHYLDGKTVRARSPFHARSGSTRTERLALLLFLNVSQIDPKRAVPRSSNPKSDKLFIRLLPQTCTPESFRTYWQPFGVVTDATLMMDKETGRHRGFGFVNFESGESTEKVLNSQPHYMDGNLLEVKRAQTKGEQRRPDYGIDTRHMNAAHHNPAAHAGGMNLMGGGVGGGGMGGPAGAGGGFGANPALGGVTGAVGGMPNMNAPFDPNAMSKFFAQMGWGAWNPMMMPGMGAGFDPTMGMGGMGGMGGMMGVSTMGGMPAMGGMGMGMGGMGGGVAPVGQGGEGSFAAPMRGGVAMGGGHRGGMRGGARGAFSVCFQSHLHLPLRKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MZZ8</accession>
    <name>A0A2X0MZZ8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C008g05395 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C008g05395</name>
        <name evidence="3" type="ORF">BQ5605_C008G05395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY80467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MZZ8"/>
    <dbReference type="STRING" id="796604.A0A2X0MZZ8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF140">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26146">
        <property type="entry name" value="PI-PLC_X"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016182050" evidence="2">
        <location>
            <begin position="22"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY80467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="389" mass="41350" checksum="B8282A1AA5E86A07" modified="2018-09-12" version="1">MHFHLWAGLVTWAALVRSTLAASVCNGHSEFCSRSYSTVSIIGTHNSYGVSSGNVAANQNYPVTTQLNNGIRLLQVSSVGPTCTDRYSELTSKPHLQVQGHMNNGSLHLCHTSCFLLDAGTLTSYLTLVKTWLDANPNEVLTLVLVNSDGIAPSTWAASYAASGMDDYSYTPSSVPIAYNDWPTYKSLIDSGKRAISFLAQNADFEAVPYLIDEFTNVWETPYDETSTSFPCTVDRVTGSYSDKMYMMNHFLGRNVSLLGETFTVPATSSLNQTNAATGTGSLGAQASSCFSQYKYYPTFTLVDYYDVGNGSVFQYAAKLNGVSYTATKIGNSSSTTGGNSSQSSASSNPNTDGTVVSIPLNGAPKVVVGVGSVMACVVGGMTVLLGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N0G2</accession>
    <name>A0A2X0N0G2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C009g05566 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C009g05566</name>
        <name evidence="2" type="ORF">BQ5605_C009G05566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY82384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N0G2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026768">
        <property type="entry name" value="YPEH2ZP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14976">
        <property type="entry name" value="YPEH2ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="747"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="863"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="795"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="863"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY82384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="890" mass="97276" checksum="74F07465A4C88B10" modified="2018-09-12" version="1">MPSANTEANPTDATRRADDMGQPEPPAWANTSSQESAAAAIENAPRPEPLPNTLPAIGHDDRPEARALVILSPRQSPSPTPPPPLADNSNLDELSRPLSITGGHAPLRPHWAMNNLPARYLARRNRIRNRNRNTHPVESENESENVSESESESESEDEDHNDGEPTDVDGADEGDLTMFVNSLRTGEASRDRRRSRITSEDRYPPFYVDFDVIEYNPDGEAAEDGEQEPALRIQPRQREEQGLAAEDGSEQGWQGWEEFERNAMAMPPSTEDSGRLWRASFNSLAVASALRAIELTCDCLDPISLQHEPVDIRRSADAHPLPRGGANLARTATIGRQAPVNSRTARNSSQPTPASSFWLHDSDATSYSFSWTRTRTPEEIQRSPSPHEVVEQPPIPTSTSDFTVMERAAMTNYILRYNELRTSSQRNFYETDNSWISDAAANLARLDNINALTRTGPDARRTTEDRAQTIGQAMRKKKDCWLVYCGQSSNGSAGLLPSGWHWHASSTKDPASSSPSGCGALVCARGLVEAPKKVFDRSGRGELEEAIASDLPPCSSAVGEMTGRMSWNTRGVAGCKGCATTDLSCRSCGNLLGYRVVNACTPCKSALAAPVTGLLWHYRRRAVTVLPRIGIVVPPPSIDLSQDLSASLFTLAPLDAQELISGPQMKWDQLPHAQIDFEDGLVGEPSEWYNPETDNSWLVTMGSTTRNKSTGHPSGGTVQHSDVELPALPSLYAEAAQEEDVGVVPARDSLYSPFSPPPVPSPWRQLRDHNAETSDTPGSPNGRVGLHRSGAIRRLASTTTLSSLTNNGRGTVRPRDDDDEGDAQAGEGRRVRRRLVTLNRDADNLELDRLTEVAGYGAAFVGRQKERGKSDKARQVRQRLGRRSGALVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N1Q8</accession>
    <name>A0A2X0N1Q8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C007g04651</name>
        <name evidence="11" type="ORF">BQ5605_C007G04651</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UPL family. TOM1/PTR1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY62078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0N1Q8"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000003">
        <property type="entry name" value="E3 ubiquitin-protein ligase UPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000009">
        <property type="entry name" value="Probable E3 ubiquitin-protein ligase HECTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010309">
        <property type="entry name" value="E3_Ub_ligase_DUF908"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010314">
        <property type="entry name" value="E3_Ub_ligase_DUF913"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025527">
        <property type="entry name" value="HUWE1/Rev1_UBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF67">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HUWE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06012">
        <property type="entry name" value="DUF908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06025">
        <property type="entry name" value="DUF913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14377">
        <property type="entry name" value="UBM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBA" evidence="9">
        <location>
            <begin position="1355"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="10">
        <location>
            <begin position="3643"/>
            <end position="3990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="223"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="816"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1403"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2192"/>
            <end position="2211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2218"/>
            <end position="2395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2413"/>
            <end position="2444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2521"/>
            <end position="2541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2694"/>
            <end position="2769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2792"/>
            <end position="2875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2955"/>
            <end position="2988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="3134"/>
            <end position="3158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="3283"/>
            <end position="3325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="266"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1409"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="2218"/>
            <end position="2242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="2271"/>
            <end position="2287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="2297"/>
            <end position="2350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="2363"/>
            <end position="2395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="2426"/>
            <end position="2444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="2694"/>
            <end position="2712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="2718"/>
            <end position="2732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="2747"/>
            <end position="2769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="2800"/>
            <end position="2821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="2839"/>
            <end position="2875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="2979"/>
            <end position="2988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="3283"/>
            <end position="3317"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="3956"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY62078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="3990" mass="430760" checksum="8C0DF6372CD43E33" modified="2018-09-12" version="1">MPAFETWATSSSVRIKRAPRRHGSTNPGIAAFVLRLSNEQSTTPQDWPEMLLPIVQAGWTWPRTDLQHWIVPLNRFDQALEKLVADYRLDSMEHPQLKPFDGPTKKIVLAILAFIKVLLENSTNRKIFSSFDRLNDLLHTTDLEVLLATLRLALRPAQQFSSTNTGMTSFAISEKRLLNLAQGWGTREHALEMVDLAADDVEIPPELDEVEWQFYKKALATAPLPSSLSPSTPATGVLRKDVDDKGKGKESKSSDTMDVEDDRRSGTSAGPSLNVHSTPAPKRQSSFHNSLLSTPLPSTPGQGPSSSNAPALQEGLTTIHLGNVRLSNKSAVELLVEACEKYGVPDSSRLELLQKIRIAQSMRSTTERRTLLLIRLLAMTIFAHTTTESHMQTRLFLYEPDLIAHLAELVHPDRAVPIEIQAASFYALEALAHFKTKLGEVASALNASVSHGILLHVFRRTVSDFDSDNAVTTHEFVDSLFTLLVFFQTNAFVGNQIVAAGIVPMLVDLIKNTRRDRVWIVTKAVLFLDSLMYGYQSAFTLFISSGGLPIFVDRIKQEIDRCLEEHCGKTVAEEDALPIGMLSFDEASLLKGLLRSIQRLMQTSGMTEGLRNLIDTSLLAAVKTILQNRPIFGAQVFALAINITATFVHNEPTCLATIQEAKVPEALYDAIGESIPASIDVLQAIPNAVGALCLNAAGLALFNERPIIAKYFSIFTSERHVRALTERDNGNLLGTSIDELIRHHPTLKDKVFESIMQSLKDIRDNARSYKPDSPDGYLLQVVREEAAASTSTLAAEGAALTSSAAAPPVTAIATTSTTGDVEMQDATAAKPTPPPSEGKDNAHLQAIDAFGRFLEGLFQHMAHGKDFAQHEPYDLLLDLLDLPSMPSYAPGTGAFSSISAIFRMLSEFKGVEAVSAILKRTKACLEQTEWLTSTYSGDSKLSSMISPTDATIDAENERFRQLCTLLSHITLLSDTYSSLSYTHGRLATSMLSVLTTPENAIVLKQLSVVLAATQREGWYLQGVLPEATDPDHAVRQTLHKAPIVTPPVGQLGTEQASQAVLATHTSTALPSNAPNVRALKEVILAVPQSVQVTLQCIIKLLVHRRSNDTAHRAASKHVATTIAHNLTDLLQWPGSSALSSDIAYATNLFRDVTAFLFDPDRPVQSGLQTLLAATFVKVGGLDAYLALFDKLQDVVSEDASGGFGDLLTTFGALKIALETLNRLTSHRMILESSQTAQLLTRERDRSSPDYFDPHAFLVHLRATILPHILQVWNKPWLRRCPPNVVRSIVGTLVGILKAQGETAVDPASTGQTPLGRVNDTEDRDRASAALDRLSVLGGLLNRDRAAAAAQQGPLAVDQTRVAQLVDMGFPRSAVELALQRCRNNVGFATEYLLQHPDLVGAARAREAAEPQAAANEAEAPANPPENQAQAQDGDAAGPDAPAPEAGNPPAPGAANGDVELEIDIVVGEDASMDEIVAAVEQELATTPIVPPPTTEMIETRSREQIDEENKATQAQLDEMRNQLKPEFLAKALVLAEDFGDLVFDIKSALTLLEIGPISLKPLLEGLEGVTFAAEDNDVRKAQDNAAAVRWRVIALVLVDQSLRQIIDPNVDAIVAASASFQREYVLRSADKDSRPKWLASVMLVADSVFSIGEAVTRTTVAPPGEESSVPTLTTLGSNWATERSGWLDLAMDVLKKGISDRETFVSTVRLLMVLTRDHGHAARFVAEQGLEPLLAAFAVERPETAACRAYVTIILRHVVEDASILLPIMESEINAWFSSSRSKNVELAIFLRGLTTIAFRNVTTFIEAVKTTCKLIPRVESSHGYLIGLQNEPQSSSTRSAEADIRSPIVDRDGAGPAEMSIDEAVRTTSKTPFKLSGSMQLPPKSVPAHVEALMHTILTTAIDATKGALVPIPVPAAEVAVPVADLKTTDSATAADTNAALASAPAAAPDAVKKNVKDAHIPADLPLGDYYQGTYALSALAELVAAYPVCKTSLLSFSSRRPKDPSSTGPVKPKLSFLHFILNDLLPVGSISTPSDFESRRRTAISNIAAIVVVALCHDPTPSSIGAPSADAHALELTNVRKSVLDSIARAFRDATSSSEPMDIRYGRLLMLSELCHRLLSSRPFTSVNKGSDETSMQIAKMMLEKNFAGILTNALAEVDLNFPSVNNLINSILRPLEQLTKVVTKVGRRPGATGGGSLVGGARRSGVDIDDSTDMEEYIDEDDIEEVIEVGSDEEEDQEPPDLYRNSALGMYEGELEPGNNEDAYMTGESEDYDDEDDMMDEMDDGALPGSDVSDISDDEDEDAIDEAEAMADEMEMRDEMDDDDDDSDSDNEGRDDDDDDSDLDDDDALIHDDLLGPGSGDEDEDEDDEGIDEIIEEGGIDGDDDGWVDEDEGDLVINDDGDLADIEAGFVDHEGTPIRAAAAEDDDEEGDSEDPDSYTDEEEHYIAGELEFEAEMTDQLHAAQGGGGALNWGQLAGDTGRRARTDMVTDSDVFGNPRRNHPSTQAAAAHPLLVETPASDGGADSMVSRRNRGAGARGTPEYEAWANNIERMLGPGGVDTLHQLLGQHGLAHLSGPDQLRVGIAPGPDGGLAMVIDPTPLPHAQGGEAQSAARTYRSSTTTAGVPPSSRSVARQLAERLGATSEFFPVQTAQRWNDESKIIQGAMTTVERSSRLTQHVINALIAPARELAHNEATERGAKENADDRVDTSGEVASEGEEDGEQVDGAEEGNDHPVPEPMDVENPPAQAAPAVTAATAAPPTAAATPLPSDDVQAVMALARSLAAGLAVPSSDAAGNTSSTAPPSSSVESSAPTMAGGPAPTPMDEEPALASPEAFSSINEPSAAAPAEASGSSNTGPTATTLAGADDEAAAAPAERVVIQVRGRAVDITDTGIDPTFLEALPDDMREEVLNQHFREARSTGPPPPVVPVESNIDTTFLDALPPEIRAEVLQQEAAQARRERARDGAAAGSTQAGVRPERTDPGLEQREREADLLFGPGGLPDIVAQVRGAAPQRARARGQGGIARQFLSALDAAAAAATGTPVAGSSAAKKAPAHREAIQLLDKAGLATLVRLLFFPQPLRRNSLQKVLVNLCENSRTRTELITLLLTILQDGTRDVSAVDKSFSQMSLRASKSLTTSKDTPRRRAGLDTPGGTLPHFPGESVPNLIAQRCLEALMYLVAASEQASLFFLTEQELRRSWKKGKGKEKAVPHTTYPIIVLLGLLDRPALLKTQSMMDYLTNLTATITRSLSALQKKSSKASLGPEATVAATESTGDVNASAAAVTTTATTSEAAQPQEGLGAAGASSGGEPASASDNAATKGAKDVSPADALVKSPPQIPASVLRLVVNVLDAGECSSKTFQQTLILIQHLSYLPEAREIISDELRSRAQALADSILPDLDELLQTTRGSDQVRGATLAKFSPASASQAKLLRILKTIDWVNGPQKKSPAASEDPTTGKKKLTVEEEKVREIFHEFRFDGLWSRLSESLLAVEARPELLYLATVLLPLIESLMVVSKYAFVGSSTKADEGMPLASPQIALSPTLQSPLEDKTMGNIFLRFTDAHRKILNTMVKNNPSLLSGSFSILIHNPKVLEFENKRAYFFSRLHDRSQRRGQHYGNLAVNVRRSHVFEDSFRVFERHTGDEIKFGKLNVKFYNEEGVDAGGVTREWFSALARQMFNPGYALFQPQAADSLTYQPNKSSSINELHLAFFKFVGHIIGKALHDQRVLEAYFSRSVYKHMLGKRIDHNDLESIDPEYHKSLVWMLENDIDGVIDLTFSIESDDFGVTSVVDLLPNGRNIPVTNANKHEYVRLIADQRLSIEIKDQIDALTSNLPFLDQALLKGLYEIVPKDLMRIFSERELELLISGLPEIDVDEWRANTNLVNFTSTDPVIGYFWRAVRSFSHEERAKLLQFVSGSSRVPLEGFASLQGMSGVTKFSIHSAGASKALPTAHTCFNQLDLPASYQSYEELRKALLTSITEGAGSFGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N3H3</accession>
    <name>A0A2X0N3H3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C004g03004 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C004g03004</name>
        <name evidence="1" type="ORF">BQ5605_C004G03004</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY69377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N3H3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY69377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="358" mass="40468" checksum="9DD5C4FE78F4EC7D" modified="2018-09-12" version="1">MYLGCQSRSESVATTALADNLARIHVGWDEAHNLRSALLRILVFAIDQLESTEQRRALANYSLVAKSWTGPAQSLLFGHLVFMDESAVARWLALSDVMLQSPAIDHHNAESVYIDGRGGQVTNVATDHVLRRVRGIKRLRIDFVNNLSTSVFTYPHLDTLTSLTLHIKLPLTYFHGARNRWVDPIRINLPFSLHHFVLGGSYHPLAFIHAVFSNAIRTLESLTTTMQAMQSPSQRALMNDSISRLEALRSFVDFQRSAEDFVGLLARLPSTIEEISTSFVDRNRLRLLTAALGQPHLGRLRSLRFMYMPRGELLSTEAGRDFIAFCRDRRINIVHGHALDYLREEHALASNEQLKSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N5E4</accession>
    <name>A0A2X0N5E4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">BQ5605_C029g10735 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">BQ5605_C029g10735</name>
        <name evidence="18" type="ORF">BQ5605_C029G10735</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ16170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N5E4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="17">
        <location>
            <begin position="349"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="630"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="685"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="722"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="SGZ16170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="964" mass="105889" checksum="AD15389E7C261755" modified="2018-09-12" version="1">MSDAGASAPEAKLREPKPDAPPLRPPTHSVAFATTELLRNSSGYRDWVLAIRSRLPSGVVRYLNTGVPLESWPASYVPLWDHYACSSICASVDSQTVLPGLSPYLDESLAAPKVWQALRERYGTVSAVDLLPVIQRLFSSDPVPVTPDLFLQFRDSFENDARLLQDSRVTVNALLASHLLARLPSSFDAWRTTFVAAQGDSTAMPSATEIFTRLYRDVKARPVDTPVAAVATPQARHGCSRPCPNPSCRKLHWLRECPDTAWAAAYRARRTAEKKASQPVAPPTPCTPKALLAIPASVSLLTLHRRLAHLPVAQIKNIVQSGLVTGVDWVYKDQELRDFYCNACLASKAHALPFARSKSIASGRLDLLHVDVAQMPRPTFGGHRYMLVIIDDFSRKHWCILLALKSDVFPRLRDWILEVENATGNKVKTIRSDNGGEFTLRNFVDFCASKGIRRELTIPYTPQQNGRVERSNRTIKEGILALLYSSGADSRLWGEAALYYVHCKNLMPHAGIGGEIPDTRWHGFAPDISTLRAFGCRAWHHLPSAKRTDLDPKAVPLLFVGFDQHAKAFRLFEPSTRRIQLSRNVVFRESEFPALRPATDVRAEPIPLPVTVDAYPDQVDPLEPSLVASPRSLAPRAEPPRPVPAAPDQGPHRPAPAREVPDQDSLAPPAPDQGSPARELPDPESPASSASDQGSSDSAISTPCPSPRPVASRALPAPPSPARSDSPDPIDLLPRPRDVASLCQAQGFPDDVDDALHSPSAVAYLASGAAALIETSPVDPAELIAPARDPPHWRAAMATPQADEWRLAARDEFDSLLRDFSAFTPIDESLVPADAKVLGSRFVFRTKRDQHGQVKSYKGRLVARGDSQRSGIDFDETFAPVAKFTSIRALLALAAAHGYHVHQADIDKAYLHGKLDAPLYIRVPDGIYMPGKVLQLHRSLYGLRQAGRIWNDEIVASNVLFRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N6Y4</accession>
    <name>A0A2X0N6Y4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="3 11">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C022g09503</name>
        <name evidence="13" type="ORF">BQ5605_C022G09503</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="3 11"/>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N6Y4"/>
    <dbReference type="STRING" id="796604.A0A2X0N6Y4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04413">
        <property type="entry name" value="NDPk_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000002">
        <property type="entry name" value="Nucleoside diphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001908">
        <property type="entry name" value="PRK00668.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11349">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="12">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="9">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGZ22541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="148" mass="16353" checksum="7A6B495CDA4D9409" modified="2018-09-12" version="1">MEQTYIMIKPDGVNRGLVGEIIARFEKRGYKLVALKMVTASVEHLEKHYEDLKSKSFFPGLVKYMASGPVVAMVWEGKDAVKTGRVILGATNPLASAPGTIRGDFAIDVGRNVCHGSDAVESAKAEIALWFPEGFNQYKLANEIWTYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N8C3</accession>
    <name>A0A2X0N8C3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C025g09958 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C025g09958</name>
        <name evidence="3" type="ORF">BQ5605_C025G09958</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000087">
        <property type="protein sequence ID" value="SGZ26794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N8C3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF463">
        <property type="entry name" value="REVERSE TRANSCRIPTASE TY1_COPIA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="172"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="651"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ26794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="704" mass="76863" checksum="B5B85D1A6D3CAAB4" modified="2018-09-12" version="1">MSAVDVAPGYTGGSLLNSTDTSPSSSPSLAPISSPATSSAGGPSIEDSDDPLDLLHSDTAVRLRLMDVHRSDDDTLVTPTPAVGPGQPSDDDSPDEIDFLSCHHRAFIATEDDDPTLDAIEPVKSITSDPQTWREAMSSEEHDIWAQAAATEFTAMRDDFKVFTIEPRSAIPPGATVVTSKFVWKTKRNAHGNVTGRKARLVAQGNRQRDGIDFSETFAPVARFSSIHCLLALAAANGYHVHQADINKAYLHGELDHDIWMTTPRGFDFPSDKVLRLRRSIYGLKQAGRIWNRHIDASLKGLGYRATGTDHCNYSRIDDQKRPHYIALYVDDLLIVSPALDEIERVISGLEQCYSVKQLGPAEYILGIQIRRLDDGSIALSQERYIMDVLARFHFDTTTRGATVPMTPGLSLTAIPGQGTERIRSWYLQAIGSLLYISLGTRPDIAFAVSYLSRFANNPGRRHWIAVKHVFCYLRATYRNELLYTRGPGKVTGVVGYSDANWGACVDTSISTMGYVFYLAGSAVSWSSKRQTRVADSTTDAEYLALSHAGKEAIYLTQLLSELHVRPVDAAHIFTDNEAAAAVAHDPVRTSGTRHIRLREHFVRDMVNQGDISLSHVGTANMVADLFTKALGPKIFSTHCYALGLRTRHPRLKSTSRSRGGGPGALARDLGARREPGTSALDLGARNEPGASAQDLGARSEPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N8X9</accession>
    <name>A0A2X0N8X9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C026g10159 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C026g10159</name>
        <name evidence="2" type="ORF">BQ5605_C026G10159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ27664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N8X9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ27664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="696" mass="76640" checksum="5D66D70D1EA12D5B" modified="2018-09-12" version="1">MLASISTTYGREHFDRRIDLGRTRPSARCLFSSTAARSEAGSSSTPPLTLEEESTPDAQSAVRETETNGFIPSVHPLLTPQLLLQSDTTTDLPSPQDLDALQPRRFTIPSHTSPESYRVVYSRVWSQTYEALSHAFTKSQLLHLAGPLGLSLDPLGDASKMRARTRGKNYLNKTLGMMNKKELCVTIMVLKWGMVDPAAVPAAAKGPKATQAIPLSDRTLFLLLSPSSTTFSHLSANHALRFSFQQDPQTSTLNLIVSGPEASVLVAQETIGSIGETADRRDFVLPDSTRSLPAEVYQTISRNAKVYLEAPEHAKESDHVLRATTNDKNGLETAERLLGLAFGEARKTRATNLIVSNAGGDKDEFCFVPFGPTSSPTFPNDSTSSFARLVDVNRRSRDGGQEIKTTGSSDVLLRIKNMCSLLPNSAKSTTKHGLKATFGHLLFPLYPSSSTPVFGPVAVDDVTSLPPHRHFLSCPPTGFLSSTGATKPTPASGLSNPPKNVYDLPFFSDLSHEEDTDDPLDRLNQLALDSPDLSSEAFRRIRYVRKPRALQPSDSLEQILEVVYLPHQDLLTRTHVRSIHTNVLYPSHSSDLALSASHQELLATTALTGFEKGHLPSRTPLELEYAGEDWMLSSDRQVRRTQVGELRIERWVETMSRGDDGAQMGVEVEWVMEDEKYGLEKWFTRVEGRVMSKGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N925</accession>
    <name>A0A2X0N925_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C036g11529 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C036g11529</name>
        <name evidence="1" type="ORF">BQ5605_C036G11529</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000063">
        <property type="protein sequence ID" value="SGY95937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N925"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY95937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="774" mass="86761" checksum="F7642F4129662F39" modified="2018-09-12" version="1">MSEYKMVRTIRHLTGFRNGGGVSNARCREKRFTLGKNGEKIERSAQRFYDPAPFVEALRAHPVIGPTLANAKPSDKVVDLHKASGGSGSYPVVRRWVDGLHARPLYANGNLKPDDIPLATFSDGTEVLAHSNANRKVNAHISGVIPMTLPPGPPKERTSFSAARDRHVLCRDRIVACIADTLEQAALGNLVGARGLASCLICSTISIPHYAPRNTKGYLPFFVPHAVPHAKAFDNDEGVIVSVLDHPEWAGLVDSATTFQTPGGRGVRLDNERNYKHYRRVVEAMKRHPTKLESLRRRTGISGEAPIEALDLFKDAYSTFLPLDYMHLIGINSGRTFINILVGNLDSKARRHSMTLSSDAIARMTRAQLLSRPYLARVEGVIVRPLIEKRKKWKAIERELFILRDLGPLSYQQFKEPEFERLTALTIRMFAAMKNDFFIDDSVDFFDRLPDVDRLEQLRLYELNEKGEVPITYTYLYVLIEQTLLLREKLLYDQDPEFLHLFPATNHRLMHVPDVMKRIGPLREYLACGTETMMGYIKGRMRSKSKPGESGMSSAEVRNMMMILRLKYNIPTMVNLRDTLPRDHALHAQQLGYKLHMLKKTAQHPSQNFVDLTEEVAVFHGGSTIYAMDFGSSLDEGWRRLEGAGASAVTLLESGNEMRNTQGTINCKTARLVQMSMEADNSQRAGEVECFVELVAMDIRGLYERFDVDGPRTLSLIGVKRLRQLVSSIPNTLRLPPTAAELAQGAGPAVTAPDTYAISVSPHATPLRQDDAWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N9S5</accession>
    <name>A0A2X0N9S5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C059g12712 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C059g12712</name>
        <name evidence="1" type="ORF">BQ5605_C059G12712</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000090">
        <property type="protein sequence ID" value="SGZ29033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N9S5"/>
    <dbReference type="STRING" id="796604.A0A2X0N9S5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ29033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="613" mass="68682" checksum="973CA116E5685356" modified="2018-09-12" version="1">MQLLSRFFRKRSADNTDDRMKQLAKLSGARLQQAKTAVRILIDLWHFFDRIYVSKKHGAAKAFARAFSDAVFIPNADDRLLMEARLAKLGMTWEEALRSPVWNKKLWRRVRRWIPPPSILEPLVREVFEKFGPLIDAKSKQPLFNKAAHEAAKRCLEAIRKGQVSDPVGIELYTDLAPCGGPDGKADDGVRLYSCQRGTNSLEGGIHRNLRQRFPKSGVSPCHANACLADYVLVHNLTVSPTSPSRFEEAATFLTHYPLYSQLTVELHRLRRKTSAFLPRHSTTVSDIVNPLLYTPSTKTFGIVPVQSPTAQMRFLIEPYHVERGTLRLEPVKWSPRNLLQNNTSAIQHMQSRLLTDRKLRHDWLAERQGTRFAVLHVHTPSERALYRYLSSKIRLGAPQNLRILEITELWNKYANGVDIFYKMPEHINTWASRWSSLANAQATMNMGGNDVRVIQALLTDPSRGRDVSMLAAKPLLGHKPPVLGRLTEIEVDASNPPTSSIRPFVATASSDAGSSADLGTSSALTRAGTTKGARHCRFCGQTTCRLKGSKLSDDGSVTGCEGACLDCGKPFGLTDEMDPNDPQSRRFCRGLTRAEMNGRARHQKKCHNFVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NAX0</accession>
    <name>A0A2X0NAX0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C030g10833 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C030g10833</name>
        <name evidence="2" type="ORF">BQ5605_C030G10833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000069">
        <property type="protein sequence ID" value="SGZ09008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NAX0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ09008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="130" mass="14567" checksum="8DED24A7D6EC8999" modified="2018-09-12" version="1">MPFELMPDPTRRFTRGEFHYLTDEELARLSPRRLEEVSFALPANREVVVPEEPRAVMELVLTPDTQDPVAKQKDVDIEVPDVHDPVIKREEADPEVNSVCDPAVKKEEADPGVDSESEVLSLFGSGTRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NC57</accession>
    <name>A0A2X0NC57_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C043g12105 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C043g12105</name>
        <name evidence="2" type="ORF">BQ5605_C043G12105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000117">
        <property type="protein sequence ID" value="SGZ32179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NC57"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ32179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="90" mass="10739" checksum="3709865D35A17FEB" modified="2018-09-12" version="1">MLPGRAPNQHERTCRAKVCRPSERARPARCRRQNLYKPHKCHRGNKELNFSKKEVSWSHAQHQPKRRAPQATSDRPPRARKRSERVFEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NDM9</accession>
    <name>A0A2X0NDM9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C022g09545 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C022g09545</name>
        <name evidence="1" type="ORF">BQ5605_C022G09545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NDM9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ22807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="327" mass="35405" checksum="D840949894AE68CD" modified="2018-09-12" version="1">MDIETALSFVPTTYRGLLGFVPPALVTILKTTSKVTKDYVQQTNVREEEVPLAPFESARHDGSNTARALGALHRGLTQAGRLESPVPHLVRANLAAAIKGPCFIHQEKSMVGLWTWFVVTIARPLVQDLFGDNSDPVGTDIFPCEVKVGQVGDGYACLYRDRRSKSAKKPANGYDIDAFEICTSCPVEPKTFVQPPSTAGVFGSTGQEVQISKASAGIAIPDLADFDLAREDVRAVSRPLCFATTRRVFNSQNSTSAILASPVPSSNSMDGHTYHLGEQMRFAPGPDEPARRRKGIILGGPYFMLTQLLVDNGKSHVSCTGVYTYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NQ74</accession>
    <name>A0A2X0NQ74_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C012g07016 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C012g07016</name>
        <name evidence="1" type="ORF">BQ5605_C012G07016</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NQ74"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY16875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="81" mass="9065" checksum="55AF682F884BBC24" modified="2018-09-12" version="1">MLLLYLVRLKRQHIQGKPEWTMAIPQSHTPTGQLAQIGVMSATASRPLSDFTFQALQMVESCWVVDPLSVDGMTLGMVDQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NUB3</accession>
    <name>A0A2X0NUB3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C018g08591 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C018g08591</name>
        <name evidence="3" type="ORF">BQ5605_C018G08591</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY25204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NUB3"/>
    <dbReference type="STRING" id="796604.A0A2X0NUB3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF66">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY25204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="264" mass="27942" checksum="9F2E094C860B0462" modified="2018-09-12" version="1">MLSTRNEFAGAKHLYVMDFNASSLPQLAKDLEARYKGLKVTPIEADAANEDAISSVCEQAIREEGRLDCFFANAGIVGANLLQHTEPSEFMEVFRVNTLSCFLAVKYASEAMKVVQKDSGKTETGGSIILTASVAGIRSGAGPIDYSASKAGVINMANTCANGLFGTNIRVVGALVSTLARQNAICPGLIETGMTTYTFERAKERGTLGKVGQLNPLRRFGVAEEIAQAVLFLASDDSSYVNGIHLPVDGGLSSSHPVVPGQAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NV69</accession>
    <name>A0A2X0NV69_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C002g00984 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C002g00984</name>
        <name evidence="8" type="ORF">BQ5605_C002G00984</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY28911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0NV69"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059141">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021717">
        <property type="entry name" value="Nucleoporin_Nup160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056536">
        <property type="entry name" value="TPR_NUP160_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056535">
        <property type="entry name" value="TPR_NUP160_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11715">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23354">
        <property type="entry name" value="TPR_NUP160_120_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23347">
        <property type="entry name" value="TPR_Nup160_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup120/160 beta-propeller" evidence="5">
        <location>
            <begin position="113"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="NUP160 middle TPR" evidence="7">
        <location>
            <begin position="1039"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="domain" description="NUP160 C-terminal TPR" evidence="6">
        <location>
            <begin position="1329"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="364"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY28911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1574" mass="171994" checksum="9E7AD482D4304ABA" modified="2018-09-12" version="1">MAVEMSYALPFGAPRTKAVTQWSYTSACAFVADHDAHEIAVPSTSTTTPDHSRRATLAQDDHALSSSTLFLPQSSQHGGHVLARVVDQGYCLELSYNAFTVGNRDDNTSFALDLGSSNQQWPPVRFVFGSKLVPQPYLVLVSPSQDDDDDDSPTAKHEGELQIYALTESGHLHVLHFSLPKLFYSSTAFDEADDDDDDNKPNLDRTASGRSHHRWCEEFTVSCLVNRTPVLMHGVDVSRVVVACADGFAASLVIADGQSLSPETYPDDLIETELRSSSNFFSVRSLIPSFSTRHLASPSQYHNFNANATASTLNSNASSQIVSFASSVPEADKPTFAFSVSRDRKLKIWDLDAGVELKTIDLPRPTSSSSSALALAPSDASSSTDSPARTTKSAGLLLSSTPQTFVKLVNVPSSSSSSTITSHLVIFSPASSTSRAAFFAYAITLDAQTKLLSELTPVGEKLCPHLANANASLVDFAIQPLALGDEARWTLSTVWDEGGECVVRTIDFPEVDPTQAMTSVVDGGTLSSNEWVTVESGTAGLASRWTAPYFDELFDTEPNKGVTEVFVEHVSYPGRYPLSTLDHALAQYEDRLEHDIAEGRVTHKPEAMELFYETVLERIVAVVGCAVSLEQSSQTGAMLYDAFNQKLKVEWLKFVTMLNESRRDALFPTSLAVDAESKIAFVVTRQAIVIPTLLDESQLLYDVAKSGLSTGRLADYYTFSYNRVIEQALSVVRAIQALRSGLDPLLIRNFENELLETLRTDRALDVGLLADDLWERVLQPCIDENLSSRIFLAIGTADQLINSLCNILTTWQTPAAINPPMWNHGLPASNLASALIADAWTATLESRYELALGLVMFVILEGRNMCDSPNVVTSRVFATFHSLSRMLWVARQGVSPNLDTELALITATASKTGISKPTADDDDDVFSRFGKMNVSKGLNRSSDAGADAEQGEPIPAYSLFHALIRSCFTPRLPISVRPLSHALTLTPPLVYIDGLLGACDVIRDTPEDANFAMRVHDLGFPTLAIGLLDMVPNGAGMMYVRGMAQLSIGGVAEAEMAFEKAASGIYASSDSTSSMSELLPADVSGSLARYYTHIVALFVESNFDGSVIRFAQLALEAFDDTSEGAPEAISSDLWLQLFRSQASLNRYEDAYTTLVSIPHPSTRSICLGHLISVMCENGVTSQLIKFAFVGMEADLERNLAFRARNSDPLATPNYYTILYAYYIRRGDYRSENPDIRTAGTIMFQQARRIGETSSRNVTFHDLATLQCQGYLAAINALSLVSPDHAWAAISTSTLAEDRAAPPKRRRLSYDIPDDELSLDTSSPPDILDLSDIRQEYTIALSRLQLAVDFPELERPSFSLQGESIVSLFSQTGAFDAAFQTALVLGVDMSSLFEVVTDRCVGLTMNPESTEDASWVTLCYEASTWEGTLASKAWLLLERHLVRHDSSTSRYRLVVLERILAIDAHSEVPAFLTEHFLKKDVGSLLRSLIKYERLGEAFGFAVRVLRSSTPTSSLASSSLPYSTFDHLLNLDPKDTVALPPAVLESKQAELQALISERIEQAEKSEKVALRNAGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NVA1</accession>
    <name>A0A2X0NVA1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C002g01024 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C002g01024</name>
        <name evidence="1" type="ORF">BQ5605_C002G01024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY29188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NVA1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY29188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="74" mass="8662" checksum="9C1E74268319D13C" modified="2018-09-12" version="1">MDTIAYLMFMNHVFMYIVHSRYTNIFFKIRIPEGVTEIEIIPVEFTCCPPLVRNASRRAVLEISMFLADGIRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NX84</accession>
    <name>A0A2X0NX84_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BQ5605_C002g01804 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C002g01804</name>
        <name evidence="11" type="ORF">BQ5605_C002G01804</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY35805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NX84"/>
    <dbReference type="STRING" id="796604.A0A2X0NX84"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000983">
        <property type="entry name" value="Rho family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="216"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY35805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="244" mass="27068" checksum="A6347309755402B2" modified="2018-09-12" version="1">MPPLCGLGGSNDEPNRHRNQEAPAQEAQRTGKPLSRKVVVIGDGACGKTSLLNVFVHGHFPENYEPTVFENHVKDMTIENVPVELALWDTAGQEDFDRLRSLSYADTHVICICFSVDQPTSLENVVTKWIEEVHELCPGVKVCLVALKCDLRDDPATKASLARYQEYPVQYEQGLEVAKSIRASRYLECSARFDRGVREAFEEASQYQAARVAIHARRRGETRGSGPGENGDHDGQRPSSCVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NYC7</accession>
    <name>A0A2X0NYC7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g02216 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C003g02216</name>
        <name evidence="1" type="ORF">BQ5605_C003G02216</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NYC7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY39427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="119" mass="13865" checksum="F698ECC70AEFD405" modified="2018-09-12" version="1">MVQPSSTVDCASRRRVIRQHLGAWLDKRQSLLPTWRAMIRCSLRQLALSNVKLRLEQLQILCQTHNLQGYSFRRSRARELFLRILLSSCTETCPACESGYIFKRSTAIDILVPRRHCVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NZQ6</accession>
    <name>A0A2X0NZQ6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endoribonuclease YSH1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Endoribonuclease ysh1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">mRNA 3'-end-processing protein YSH1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BQ5605_C016g08271</name>
        <name evidence="16" type="ORF">BQ5605_C016G08271</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY21759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NZQ6"/>
    <dbReference type="STRING" id="796604.A0A2X0NZQ6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10890:FF:000001">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021718">
        <property type="entry name" value="CPSF73-100_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF11">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11718">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01098">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="13">
        <location>
            <begin position="41"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="14">
        <location>
            <begin position="283"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term" evidence="15">
        <location>
            <begin position="522"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="654"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="720"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="745"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00075008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SGY21759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="867" mass="95558" checksum="7FB8C65461973C68" modified="2018-09-12" version="1">MSKRRAVGDFAGVPVISAPGIIQGIDDEMHVQMLGAGQEVGRSCCVIKYKGRTIVCDTGVHPAFSGMAALPFLDELDWSTVDAILITHFHLDHAASLTYVMEKTSFREGNGVVYMSHPTKAVYRFLMSDFVRVSTAGSDDKLFTEEEMLASWSTIIGFDFEQEILLPASNNPESSTSSSSNAAVRFTSFAAGHVLGACMFLIEIAGLRVLYTGDYSTEEDRHLVPAKLPIWEKKPDVMICESTYGQVPTFPRTGMEAQFTTLVSNIIKRGGRVLLPVFALGRAQEILLILDEYWAAHPELHHVPIYYISSLALKCMDVYRQYIHTMSPNVREKFARGINPFDFKAKTSFIRPLERGLAKLNDKGPCVVMASPGFLTNGTSRELLEKWAPDPRNGLIITGYSVEGVMARTIMNEPTEIQALNGGAKISRRLSVDYISFSAHVDYTQNAKFIDEVMPAHLILVHGEANNMSRLRSALKTKFAERKDDIQIYTPRNVETVKIRFRGERMAKALGTLAETTPKAATPLSGLLVSKDFTYTFLAPSDLRDFTGLSTSIILQRQRLTLSVSWELVQWHLQEMYGKIQQGVDKEGLMTMRIMDIVDVKAVGKMDWVVEWVGSVSNDMVADSVIALVLGVDKSPASVKIRLTVVDWSETSMGASSHCSHRHPHAEPITPPPKTTKTLDDAESAGEETSQEKDLPTRLDRLIAFLDSYFGKVELVIPGPKTAGVSSPPLENAAESEKSTEPSVPLEGDTELTPPTTTTTNPEDEEHLAEVETTTAPTLPTQPLVPVIRVHLDDLIADVRVEDLQIICENESFKARVENVVGLAMAVVRPLSEMGAGVFLESVKEVEEGPRGKRVAKVVEGEADNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P030</accession>
    <name>A0A2X0P030_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C019g08963 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C019g08963</name>
        <name evidence="10" type="ORF">BQ5605_C019G08963</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY23648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P030"/>
    <dbReference type="STRING" id="796604.A0A2X0P030"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004698">
        <property type="entry name" value="Zn/Fe_permease_fun/pln"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00820">
        <property type="entry name" value="zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF32">
        <property type="entry name" value="ZINC-REGULATED TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY23648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="405" mass="43078" checksum="326A5DBB48F974E4" modified="2018-09-12" version="1">MTEVDCSFSFSLPCHAFAPCAYASPELSARSHSAVRPGPNSTTSNQQSADNSTLTADAAESCAGPNTFNGKLDLRIASVFVILVTSLFGTLLPIVSRRLKSVPDVAYRIVKYFGSGVIIATAFIHLLAPAWDALTSPCLQYGVWVEYDWAPAIAMISMFSLFLVELVAHRAGASYLAKRGLRAVDAHSQGNNQPSHSTHGAHIDDRVAVASSPLEDLEGDTRKEGLLSDDESEETASLTDEAVMARIIGVAILEFGVIFHSLMIGLTLAVDPDFSTLFVVLIFHQMFEGLGLGSRLSALPLPHAYRWVPYIAGTVYACVTPLGIAIGLGVRTTYNPNTATASIVSGVLDATSAGILLYTGLVELLAHDFIFNKEMARDASNVKVAGSVLCVLVGAGIMSLLGRWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P1T1</accession>
    <name>A0A2X0P1T1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g04087 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g04087</name>
        <name evidence="1" type="ORF">BQ5605_C006G04087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY55874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P1T1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY55874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="117" mass="12862" checksum="9E171EFD4E9A2FA0" modified="2018-09-12" version="1">MHHGRSATSGRWAIDRVLLNAFTKVFTCCIHQVITCDCKRDREQIGECAGLNSHYTTQAQSFSIRDYLGPQTAVGTHSKARHGECERTKSTGHFSTCCSQGKVQLPPPPQQGSSLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P231</accession>
    <name>A0A2X0P231_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BQ5605_C002g01559 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C002g01559</name>
        <name evidence="12" type="ORF">BQ5605_C002G01559</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="1">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY33838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P231"/>
    <dbReference type="STRING" id="796604.A0A2X0P231"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010255">
        <property type="term" value="P:glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000007">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000181">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF369">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-2 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="49"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="173"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="198"/>
            <end position="204"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="223"/>
            <end position="227"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="292"/>
            <end position="295"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY33838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="384" mass="43207" checksum="18F031D50C04765D" modified="2018-09-12" version="1">MGCSSSTPATMGAVPKESKDRSYAIDKQLDDDAKRLRRECKILLLGSGESGKSTIVKQMKIIHQNGYSRDEMLLFRMTVYKNVIDSAQTLVLALRRFKLEPTESENREYAELISEFRLEGDSFSASPGLSLAQPGAAPGGGLDPEIVHAIDSLWHDPIIPSVLDRSSEFYLMDSAPYFFDEIKRIGTVGYVPNESDVLHARTKTTGISETKFKSGQLSIHMFDVGGQRSERKKWIHCFEAVTSIIFCVALSEYDQVLLEENGQNRMNESLVLFESVINSRWFLRTSIILFLNKIDLFKAKVPKIPLEKYFPEYTGGADVNKGAKYILWRFTQLNRARLSIYPHLTQATDTSNVSALWSTAQIRLVFAAVKETILQNALRDSGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P2G6</accession>
    <name>A0A2X0P2G6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C002g01709 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C002g01709</name>
        <name evidence="4" type="ORF">BQ5605_C002G01709</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY34971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P2G6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039135">
        <property type="entry name" value="NAT9-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13256:SF16">
        <property type="entry name" value="ALPHA_BETA-TUBULIN-N-ACETYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13256">
        <property type="entry name" value="N-ACETYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY34971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="149" mass="16978" checksum="DE8412300CCBACEF" modified="2018-09-12" version="1">MPAPAYTSNGVANQGKNSQSRWQPTSFFQPTRARWHLRDGPTTWGVPRSNWLGLALRPPYPIIRNQAMLENQSTALLGPRVILVPYRSVPHGPLDEAMRHHVPRYHEWMSDPAVREATASEPLTLEEEFAMQESWRVDQDSEHTANVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P345</accession>
    <name>A0A2X0P345_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g01961 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g01961</name>
        <name evidence="2" type="ORF">BQ5605_C003G01961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY38117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P345"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY38117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="49" mass="5264" checksum="AD650F970515F295" modified="2018-09-12" version="1">MDLRARVIYIAVMSPNRPTSLEHASFDELPPPSTASVHPPGPPPLARAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P4P5</accession>
    <name>A0A2X0P4P5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C004g02911 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C004g02911</name>
        <name evidence="2" type="ORF">BQ5605_C004G02911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY68688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P4P5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY68688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="455" mass="50121" checksum="56C6CE870F7F5876" modified="2018-09-12" version="1">MSLPPSPALPIPSSGPHTERALERIANVWIGAEGAVLTQAGILFLKTELAQDTSDPALRLDISALEEAGLHPVLAHALGSARPGDFLEQFGARYWTKNLQPLPNADEAPPRSFTSIQNLGDLSTYTADELDKDPDGRLIAPSSLFLEVLTRTVRMDITVGRPPAAPTATALFAASGLQERPNETDDAWTDVSEDNNGKETPAAQRQTPMAQIARLDPRSKRAKPAEPTLPSALAPYGPAPAAPVAPVYQTDEEDASPNSVPGDDAKVFYVSILAVPSTAYDGLPKYVVSRQKKKELYRQALYYLRSHPYRLDRQAERLKKSHGFNLDLVEFMKVLTGHHVSVVDADNPASPDLFYMFQTSSVANFYGIEAMIKSKAVLPKKTLTPAGHTEALMKLERLEGVVFNSHQGRDWHHYTRFLRELAKDPSLGFDFMVLYDNKFRRELADRSSQSTSFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P586</accession>
    <name>A0A2X0P586_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00086 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00086</name>
        <name evidence="2" type="ORF">BQ5605_C001G00086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY43934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P586"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY43934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="110" mass="12597" checksum="B069B1A3D98896E0" modified="2018-09-12" version="1">MKLARRRTGVSSCSAGHMTRSSDLGLILIGIGIDRHPSLRFSHGHPRYLDISSINLRIIPPFRMCSNGYQRNKTVLKNGDSRLVGSSDWPRRTRDLNRPLPYSKHWNSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P6S7</accession>
    <name>A0A2X0P6S7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C001g00736 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C001g00736</name>
        <name evidence="8" type="ORF">BQ5605_C001G00736</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY49088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0P6S7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000001">
        <property type="entry name" value="Paired amphipathic helix protein Sin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000003">
        <property type="entry name" value="Paired amphipathic helix SIN3-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.11">
        <property type="entry name" value="Paired amphipathic helix"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013194">
        <property type="entry name" value="HDAC_interact_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003822">
        <property type="entry name" value="PAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036600">
        <property type="entry name" value="PAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039774">
        <property type="entry name" value="Sin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031693">
        <property type="entry name" value="Sin3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346:SF0">
        <property type="entry name" value="SIN3A, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346">
        <property type="entry name" value="SIN3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02671">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08295">
        <property type="entry name" value="Sin3_corepress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16879">
        <property type="entry name" value="Sin3a_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00761">
        <property type="entry name" value="HDAC_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47762">
        <property type="entry name" value="PAH2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51477">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="Histone deacetylase interacting" evidence="7">
        <location>
            <begin position="525"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="89"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="283"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="814"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="976"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1392"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="169"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="843"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="893"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1392"/>
            <end position="1414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY49088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1424" mass="154962" checksum="417D949777E0911B" modified="2018-09-12" version="1">MHSGNYLDRVKVTFNDQAEVYDRFLTIMKEFKSQGIDTPGVIERVSTLFRGHPALIQGFNTFLPPGYRIECSVSSQNEAEGGMTITVTTPMGSTTRTQVPANASASATANPSTASAPTSRSTLPLARSPLATSTTASKDVAHFSQPAQPASTGQTPSMGRKDVKSEVQAPSGPSGSAISGGPPLPNSAPAVAAPPTASAPAPADAAAKPPMEFNHAINYVNKIKNRFVREPDTYKAFLEILQTYQKEGRAIQDVYAQVTILFRSAPDLLDEFKQFLPDTSAEAGAQPQVGQPVPGPRGLTAVAGQKRPATTTSKSAAEPTSAKKAKTGKNKAAPEKAGKRKTELKDLTRKSSGVDGTTNTEADSSMGTYTHPSHPAPYGQSYPVAGYGTQPQVLPVAYAYEAPLPPPPAQPLLAPKSQASVNDIAFFSRVKLHTNDQATYHEFLKLLNLYTQDIIDLTALVSRAFLFIGQDALLWREFRDIVGWTDGKPIGDTGGRIEVVDGIRIIENVPTVDGPKRARADDGKLWESYGPSYRKLPPNEISLNCSGRDALCWEVLNDEWVSQPSWASDEGFAVKRQNPYEEAMHKSEEERHEYDYYIEANLRTIALLEPIATRIAIMEADERATFRLKPGLGNQSKSIYQRVIKKVYGKVAGSEVIQALHENPCVAVPIVLARLKQKDEEWKRALREWNRVWRENDAKNYWRSLDHQSISLKANDKRLLTLRHLVTEIETVKRQQRQRASGSNRPWTMPSYQLQYELVDRGAMFDTMRLVFSYLDRTSAISNSEKDKVETFMRQVLPLLFALSPSEFSLMTMPVGRGAGDDDSESLEGASEAGTSGLDDVTEVTSSIGGSVTGHSRRAGRKMGSDLRKKALKNAVGPARTSGREPGRRSKVSSPAPSSRGASPAPTPAAGETDQVMADALPTVSGLASMVTPEVEAEAGIPEVNVIDSSREQSADVASPQLGGDDVITVGETVSADMSREPSASNTLPDATDSPELVIPVEDKPRGVDVRKQWNVFANSNLYGLVRVFQVIYSRLVLLKTSATVVAVPPPREPITEKSVPSLSLSLTMAPPEQFAAPSPTGSAYYQRALALCEALFDGQIDQIAFEEKLRHMFATQGYMLATIDRLIHNLVRLATASLGDGKTQDLVELIEQDRSHSDRSTPQQQMFYRAQAESALGNDENLYRIDWVPSLRRLRFQLLGKDVLTTEDMAVADQEWKTYMEQYVLADRTPGLNTEPEKPFLTRNLRKTATSGSTAIPASVTAHSGLQSKICMRSYRIFYVAHTEDLLLRRRSSAPDSTQLRASRSAAFEDWLEKKKEVLGEKAKLKDEQKAQALAKKASLAEAEAAKVAAITAAAPTTTKVEETPLNTETTVVAAAPEAMKEPEPVTATIAETATPAPSEATTSTTTTAATAIPDEDVKMADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P8W9</accession>
    <name>A0A2X0P8W9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxidase</fullName>
            <ecNumber evidence="8">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C009g05615</name>
        <name evidence="11" type="ORF">BQ5605_C009G05615</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="8"/>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY83045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P8W9"/>
    <dbReference type="STRING" id="796604.A0A2X0P8W9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00691">
        <property type="entry name" value="ascorbate_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000009">
        <property type="entry name" value="Ascorbate peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000005">
        <property type="entry name" value="Cytochrome c peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002207">
        <property type="entry name" value="Peroxidase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF36">
        <property type="entry name" value="L-ASCORBATE PEROXIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00459">
        <property type="entry name" value="ASPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 8" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="10">
        <location>
            <begin position="89"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="289"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="302"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY83045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="326" mass="36267" checksum="284BAA32588EAD32" modified="2018-09-12" version="1">MATPNKDYDAVRKDIAKVIPRPDYDDGSAGPVLVRLAWHASGTYDEKTQTGGSNGAGMRYECEGGDPANAGLQHARVFLEPVKEKYPWISYADLWTLAGVVAIKEMGGPDIPWKAGRTDFIDDSKCPPRGRLPDAALASDHLRDVFYRMGFNDQEIVCLSGAHSLGRCHSDRSGFEGPWSMSPTKFSTQYYRMLTKFKWEKKDWTGPFQYKNEDLGEELMMLPTDLALFEDPKFKPWVEKYAADKDLFFSDFSKAFAKLIELGVDRSEPVSVDLYSGVVRQRSSDCADGPIIIPQQYKPAPKKSDELGAPEHGDGLGHKGVGKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PAP3</accession>
    <name>A0A2X0PAP3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Peroxin-10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">BQ5605_C004g02716</name>
        <name evidence="22" type="ORF">BQ5605_C004G02716</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY66881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PAP3"/>
    <dbReference type="STRING" id="796604.A0A2X0PAP3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16527">
        <property type="entry name" value="RING-HC_PEX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350:SF0">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="21">
        <location>
            <begin position="371"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="347"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="SGY66881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="423" mass="47185" checksum="A0F21573164CC1AE" modified="2018-09-12" version="1">MAEPRPSATDSSATSVAGASTLSAPSNLAPAVPPRPQPRPSEVAASARRAAGPSSAFKVPFFASAAQPEIVRANQKDLYYLSQLRERFEDVARSLLGTRWLQNWNKELQHGSRLAYFGLTTLLGSQTLGEEYCDILQYDVKTRKPASPRKRGLLISLHIVFPYLAARLYAAARRRLIARHESFLAARAQEDSLDDLFSSGEALPPLKKSLYKRMMESIAALAAEMPSFETLTEDYLRSVHLAVFYLFGRYYNLSKRGSGIRFISTQSRPTGQSASGGAVPTSYEVLGVLMAVQLVVRTLLAIRRRRAAQDMQIKKLPEREEREKQQKEATKKRFLVDGRPLSSLVFDPDDPEQASPYPDEEEGADARDRRCTLCLGTRRDPTATECGHVFCWECVVGWAREKPECPLCRQSIALSNLLPLYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PBN7</accession>
    <name>A0A2X0PBN7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C032g11063 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C032g11063</name>
        <name evidence="1" type="ORF">BQ5605_C032G11063</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000067">
        <property type="protein sequence ID" value="SGZ04430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PBN7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ04430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="282" mass="30714" checksum="CA2ED21FAEED602E" modified="2018-09-12" version="1">MSFVACPKWHLNPRIIEVENGFRIADEVAPPPRDRKGTHVLSILVHGATSLVIPQSHTPNDWLRLAYECNCLETAFTFQALQMVESCWVVDPSSVDGMTQGIDDHCGRCGWGDSGGLAIWTNTLKLPNRAPTLDHLFAHDGSFQQWRNHAAKYDPQATTPDLFISAAGNERGGRAGADTVQEEALAGKIDAALVACVCRHNAVSETSNLERSGGTLYYALALIKHVSEQEQPEARIGVLICHKCLGAFAHQWPCQVELDPQLFPNKFGCTDGEGVQVSLTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PC14</accession>
    <name>A0A2X0PC14_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C031g10966 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C031g10966</name>
        <name evidence="2" type="ORF">BQ5605_C031G10966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000068">
        <property type="protein sequence ID" value="SGZ06744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PC14"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ06744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="792" mass="87773" checksum="AF95AED9687581B7" modified="2018-09-12" version="1">MNSELRFYPVITSSSPEPPSQRTRKRTREVSMSADGYAECAATSVDAPVLALERDITASHQYLVQITSPSPSSSPSQLSSCWPSSSSLSGSNSSPPTMSDLDPVFTALQDGTRHIEDYALLKGVIVPRLSVRSAPDLVEQVFGIDHPAFEEISQRARQLGKQVQSGQDQDTQAELRKLFLEAHDSSRDPRLEPSTSQLAWMQGVARLVSRDERNVDRHRSAQTDPTHGKQFKLAVATAERPARLYLSDIFERPFDSGQDSDKEAKEWTPFLTCCKVDSSSKRLLWNRVLVPCAFDASPQRSQLPGGPGPFAPELVKVVLDLTQHVLPHPTRLFAPGLAVNERQAYLVVSDLETCRVATIMDCWGQGFGELAAVLSILLDLDVYSAGFCPFFDYTYHPTSGIAPASLLTSVFESSVGRTVKFEDKEPIELLSCAKGDGGQHLSGRCTTVFQLTRPSLSATATAPEISTLSPSFVLKMQLVGPNFVRVESNVLSKINAARDKGALLPATSAASMPAAKKRKRDETRRTPHAPTRRTLELLVLRNPSPLPQPLVRRHRGQQEIPLAQVFQVFDQLLTVLTTLHKLGFHHRDLSLGNILHFEGHLVLIDWDGGVAADPGAWFGIAAREEGRLRVTVKSAPRQALKCNAIGFDYVPEYRLAHAFESAVYCLLQVLAYRIRPEDPAWDYFNFRYHPARSGACPDRFEDQESQLVDRRASLWGEGAGNDVDPQHRERLINMIRREDPKLDESLDSVTRLYPVRMTSPFTSKERSPAMDAIRVGIRELTARHSIGKAVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PC75</accession>
    <name>A0A2X0PC75_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C005g03177 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C005g03177</name>
        <name evidence="3" type="ORF">BQ5605_C005G03177</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY72498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PC75"/>
    <dbReference type="STRING" id="796604.A0A2X0PC75"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF286">
        <property type="entry name" value="5-PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G07600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY72498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="467" mass="52052" checksum="CE69324426221E11" modified="2018-09-12" version="1">MAPSKYRVQCCTYNGHLAKGHKDLNSLASWLAPTLGEGNAAEGEAPDFFAVGFQEMIPLHLALVGLTRTALDQHDHQIKCAIEQHTSSNGERETYTLMAKQVLGGIALLVFTRDATVTNHVVDVRVATAACGIFRRMGNKGGVGVRITLNSEGDESSDSKSSEDGESDTGNNVFTFVTSHLAAHDSGLQRRNEDYQSIVERLIFTPNGPSQHYRTQQQRSVFPRIKSKSTDGIQIYDTTYLFFFGDLNYRISTVTPKSLSKQLIAHKIHNDLPALLTHDQLRQEQSKGRTLHHLREGEITFQPTYKFKVGTVDTYKAFTKRVPGWTDRILFSCWSDGESGAGEFIKREILKSGEVVERSAKRKGAKVELYTSIMSFTGSDHKPVTAIFALPRHPKGSLGLRLPFTSPYRIDQGWRRKKLVGKVLDRFVGFWWCIVMLCGLGKDARLGMATLVIAATAAYYKRTLLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PF60</accession>
    <name>A0A2X0PF60_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">BQ5605_C009g05670 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C009g05670</name>
        <name evidence="14" type="ORF">BQ5605_C009G05670</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the creA/MIG C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY84019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PF60"/>
    <dbReference type="STRING" id="796604.A0A2X0PF60"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000433">
        <property type="term" value="P:carbon catabolite repression of transcription from RNA polymerase II promoter by glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000089">
        <property type="entry name" value="DNA-binding protein creA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000018">
        <property type="entry name" value="Krueppel-like factor 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051007">
        <property type="entry name" value="creA/MIG_C2H2-ZnF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428:SF1">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="182"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="16"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="229"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="312"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="644"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="754"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="16"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="229"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="274"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="321"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="338"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="410"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="500"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="511"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="534"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="572"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="586"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="722"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="765"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="808"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="837"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGY84019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="876" mass="92547" checksum="88F0535C7048C7C1" modified="2018-09-12" version="1">MATTASVLDRVLMSSSYASLPGSPSTLPMASSTSSSPSTSLKLPSQQPPAPLQPQPHHHYQPHPQAGPSHHHHPTPMTAHLGAPYADPLGHPTASSLPSTSMSMDHHHGDPIHDVGAMSASSSLPRLDSAGHTLDQSVTAASLTVDKASIPRPYQCPLCSRAFYRLEHQTRHLRTHTGEKPFKCDNPGCEKRFSRSDELTRHVRIHSTDRGKKKAAAQAAAAAAIAAAGGVPSSSSNGGASTSTSGVSTPSKRSTNSTPTTSRPHSPTEDEGSPEPPQRLPPPPAHPAYGPPMMGYPYGYAPPPPGYPAYYGQMPMYAYPYGPPPPQHYPPPAPHYPPLGYGFSLPPQHSQQQSHHPQHPQHAPQQSHPQQQQQQQQQQQAPHAPLPLPASTEQPRPLNALALAAASGLHEMEREREIATQREKDSKNNSPYGSYDPGAYWPQYPGQAPLHYPLPMQQPQTMPPPPHQQHQHHQQQQQQQQPTVHSNLVPSSEDHKSQVGASSSSSSSHAGPRRHRPSHGTHSHPHLPHLSLPHNDDTAARHSYSHDASHPAQHSSFSRLQHRHTYSPYATAASTDHSRATSPAHSHSDGESDDGRPTTGLATVPGSGHQHAMGQLQQALAYHAQPSTSPVLGPLKGLTLMSAAASRAGSRHQSRASSPVHLAPLHLPPSLERIANGAGMLRPDGTPFLPEGSTPNSPENRGHGQIPSNHHSPAPMPTINRSGGSTSSNSSYGSPAIPSHLAAAASNQQTTLPSLGSLGAMLNHQSSNSNNQNSQNSSNVGSAGSSTFFPKSSSSSSQAASPLGGGFDHSSQPGSHPSSTSNSNSASSDSLAAMGNASASHSNYPRSGFTLSPLHTASNCQQQQQQGPGGSDAMEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PFP0</accession>
    <name>A0A2X0PFP0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C039g11764 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C039g11764</name>
        <name evidence="2" type="ORF">BQ5605_C039G11764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000060">
        <property type="protein sequence ID" value="SGY89707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PFP0"/>
    <dbReference type="STRING" id="796604.A0A2X0PFP0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY89707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="421" mass="47307" checksum="45D046D67745A2B6" modified="2018-09-12" version="1">MIPTLRVLSRSRSILFLDQVPPTSASDAPVSTRSHPRTRRRGPAHPVVPNYEDKDEAHGNVDRELSCDVQMAVLRLNSCGCTTWHYHLVSILTSPLRRDLLTRKVLPKGTLLPPPTNSTKPWFSSLLPRNADFLLQFKLLQPKPSSTSTLPLTPTSLLHPRFSDPQPGRSVYALCWKEGVRLLREKKSYKRLSSRASLALEPTLQRIESSLARRVHQEIVLLNKRLISVPVEQASEEALSKVVRRIKGEDLGMLSEVKKEVEVCGLKAILDLRTHDETNKEHGPEQWFGSLAPSDPSKLPIPLFTLGDYFNTVQLPPSSYEACKIAMETSEGKEMTLNDLVVEQLDKVVGTFRKRGLSKAEREALWLASQAQAQTKKKFTRNEGGVFGIYGPGTRSEADRQSVPLLKALWRLGLWFGKGWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PHX1</accession>
    <name>A0A2X0PHX1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C031g10941 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C031g10941</name>
        <name evidence="2" type="ORF">BQ5605_C031G10941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000068">
        <property type="protein sequence ID" value="SGZ06421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PHX1"/>
    <dbReference type="STRING" id="796604.A0A2X0PHX1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF9">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03215">
        <property type="entry name" value="Rad17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ06421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="162" mass="17652" checksum="0996F66EE78B8090" modified="2018-09-12" version="1">MAAILDHQDDDTPMLDVPHPALDKGKSKARASASASNGLDALAMDVMPWVEKYRPVTLDDVVAHKDIISTIDQFISKSRVPHLLFYGPPGTGKTSTILAVARKIYDGNEASMRNNCLELNASDDRGIDVVREQIKNFASTRMSNAGTRVRNPPCSLGLFNPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PID1</accession>
    <name>A0A2X0PID1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C032g11051 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">BQ5605_C032g11097 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C032g11097</name>
        <name evidence="2" type="synonym">BQ5605_C032g11051</name>
        <name evidence="2" type="ORF">BQ5605_C032G11051</name>
        <name evidence="3" type="ORF">BQ5605_C032G11097</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000067">
        <property type="protein sequence ID" value="SGZ04218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000067">
        <property type="protein sequence ID" value="SGZ04907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PID1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ04218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ04907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="295" mass="33021" checksum="BD6AD3ED7E4CA7B8" modified="2018-09-12" version="1">MSVQTPRPVRGPPRRHPSIDFRASPLRSASRASPATPAPNHSTKPTTVLGHWGPRLTQEDRRDSSESRNKIKVILGESLDEDSTPRPVQIEAIAALFELDQFGNRDRYDAVFVTAPTGSGKSVIFEAMYLIYGRRTVTIVFSPLNALSNHQSHASFRLPLSIERERKRLWYLRRPGETASCTGSWTTPITRSDLLHYDCMYRLTSCLTSALGPRIHWPGVQTVTQYGRTTVEDNIQRKGRGGGSLFWSLGGTHISTSGMHGDRPRLELLTENELSSLFFYESKACLHALAIVLYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PII2</accession>
    <name>A0A2X0PII2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C108g13200 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C108g13200</name>
        <name evidence="1" type="ORF">BQ5605_C108G13200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000071">
        <property type="protein sequence ID" value="SGZ10327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PII2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ10327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="90" mass="10047" checksum="EF32E61076FC69E1" modified="2018-09-12" version="1">MLGHNKTRRRPLKTSTSAETRFFFFFFFFFFLTGAHKLQSFGLAGTATKRAKGGYKATTASSWVKVKPLRAKSAAQIKARRAPNADSNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PLP9</accession>
    <name>A0A2X0PLP9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C025g10032 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C025g10032</name>
        <name evidence="2" type="ORF">BQ5605_C025G10032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000087">
        <property type="protein sequence ID" value="SGZ27034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PLP9"/>
    <dbReference type="STRING" id="796604.A0A2X0PLP9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005299">
        <property type="entry name" value="MeTrfase_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31009">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE:CARBOXYL METHYLTRANSFERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="717"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="388"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="757"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ27034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="935" mass="99741" checksum="9DBDBA1ADF568EC8" modified="2018-09-12" version="1">MPSSSSPTRSRAIDMPSPVPSTSAVPYSESITAPISHLGICDANGSDGEDEEEYDQDVPLSFDSNQDTIAARRSQVSSAKAGRRSAISRRRPSRGTSSETVVGDGAMSPSSMKSSPSVTPGSSPTRYRKASATIQALKIPMPQSSATSFTDSEACLSAMTATINNFGLVGNRHGSSVTPTTATFPRLDADTPHASSARSGIDSSRTPKLDDGHTRQNVERKFSPIPVVESSRRQVDMPGAVSSGGSANRKDYVPTLPSPLSNSYITSDDYWSSGAGFGFDLISPRLQGDFPFPSSSPGAGPSPISMSSASSTNAVSAPASPFSTTSSFHDGGLSMSQSPPTSLPRRLQALPSPPIRPDSGGPRARGRGHAVSIYDRSSPSASIPPYQTSTSSSSRSTSLSRANEMPLTPPESVSESGRHSIFSSTDAWHDVFGVAASSMSYASMDYRLPQGESAAAATRAATSSKQGMADDLMSLQDMTAAPQRQSMPLGHHTQSRSAGSLADGGKRVNNHDLMAGSGGGHFGPATRELLAAAISQAIDRVPLSAEDEVIHMVEYGAMNSRSASLFPAVISNLAIRHELLRKEKGLNVGGDDALSFQITHADRLDADFRPLAKLLETSSDSYLNAHWLSEHRPSLENQVFLSFVTRPFGSKVMPRKSVTFGFSAMALHWLSTDRKYRMAPASIAHGELMAFLSARATEFKTGGLLALAYIARSEDKATSGLNRGPSAAARIGGGGEGLSRPTIVSASSDPEGFNPASVSSSLESSRPSLRHRSATTPVVPTLRKDIWEMFTSVLSLAIQRLVSTELLKPAVARQLLALPIHPRTPKQSKAVLKSMQHAWDVETEEIVKLSHPAWAGLKHETVSPASYADQSIQLLKVFWESEIRSIMREALVSRAACEFTLDCLWNVVKEKLEEEGPHPLELEVQIILLRRKPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LUI7</accession>
    <name>A0A2X0LUI7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C014g07668 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C014g07668</name>
        <name evidence="8" type="ORF">BQ5605_C014G07668</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY19517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LUI7"/>
    <dbReference type="STRING" id="796604.A0A2X0LUI7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF198">
        <property type="entry name" value="AZOLE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="476"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="506"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="537"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="613"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="82"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="642"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="653"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="677"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY19517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="693" mass="73914" checksum="5E5B76AA4001B39C" modified="2018-09-12" version="1">MSRPDSLHDTLNDRDAREYHSRVGGQIDATTEGLEAAAGVDGPAITGQELDTSPQATATEDKLAPTAVDESTILTGKKLAIVFVSMLLSIFLIALDQTILATALPRIASDFKAFNLQGWVSSAFILTRTLALFGSCCYSLTKANFYSCLTETGFLLPSGQLLRVWPASELRFFLLLLPSCFYLRESVDAEKNTDLSNICHNPKEHCLLIAIVLFEVGSALCAGAPNVYALIVGRAISGVGAAGIFTSMLQILAQVTRLEDRPRLFGFFGAVFGLSSVIGPLMGGALTDSSTYGWRFCFVLNIPVGAVTFTAVTFMLKASPPLGAKPDETTMKARIRNTGRMDWVGATLLFAAITCLVLALQWGGNTKPWNSGSVIACLVVAVVLGAASILWQSWLGDRAMVPGKVFKSLSIFAICGYSFTTRFALLIFTYYLPLFYQAGRDHTATKSGIDILPFMLGVVISVILGGQIVARIGRYWPFLVIGPVFMSIGSGLMYTISVSTPSPTLIGFQILAGIGVGLSMQNSLLAMQAEFKDNPKLVAQATSMASFSQFLGGTIGLAVGQAAFSSRLSANLRQYAPTAPASVIERSPLAIYTAIEASIRPDVIKAYVKALDIVFILGVPFGVLALLLSLLIKNIDIRAPKAHAKPKDEEEGAATAHAETASSPEKIAQKVDTVSDDGQHAGADSKKRLSSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LUS3</accession>
    <name>A0A2X0LUS3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C017g08370 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C017g08370</name>
        <name evidence="2" type="ORF">BQ5605_C017G08370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY19892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LUS3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY19892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="236" mass="26389" checksum="A0AF3E80CF81B2A1" modified="2018-09-12" version="1">MGSGSARLAHSCASLPLLYRFTGLFRQLRFRREQIARLRRGRPPECVRSASPLLDLGSTLPHRPASQPPRNDPARAASQIFSDPRSQLNNTDIECLNIQHEGQGEGVEWINPGPVSRFSHCTQRPFSKSVIDGNFQADTDRLTTSSCTKEASASPRPKALHLRRSGCQQLDPGANRAWPRRSRIGRTQRYQVAVGCVVKANKESLRCSSRGCRSLGSRRNYWDPKPRTPLCSQNNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LUT1</accession>
    <name>A0A2X0LUT1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C017g08467 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C017g08467</name>
        <name evidence="1" type="ORF">BQ5605_C017G08467</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY20102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LUT1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY20102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="35" mass="3858" checksum="AE2178A502889C98" modified="2018-09-12" version="1">MLPACNPGCWMARGLAQHGGWCGLQHVHLIDKKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LVC9</accession>
    <name>A0A2X0LVC9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C016g08145 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C016g08145</name>
        <name evidence="3" type="ORF">BQ5605_C016G08145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY20791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1061"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="449"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY20791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1854" mass="203322" checksum="9B242F668A987A9D" modified="2018-09-12" version="1">MPDPPGAQAPPPDNPLGGNRASDDESLNTLTREPVTGGTANPPAWSTEATQARLDCEKVMQNTFRVLGIVPSGKSTRRLMVLMHDASTPPSQAPLLARAAQRAVRNDAAPASNVIRVIMDGPGSPRGPVQIALRKHFGLAETPFMFARPEGVVLDPEVEKLFSKCVKLNPIVTKATKRFPIARHMYELVFESDQACLEAAAAGPFSHHGKEMVTELPSASPLNHVVQVRFTLPSSSSATPASVLRQSLDDALTLSFGRAGRTQGYTLMQLQRGLAVDPNGDPMAMTEDGFHCAYLRLHADLFQGSTETQKAALNAALPQEIEILGAKYGLRHEFETHYCAVCDRAGHQWGACRKPVSTPATAAPVPGASTSTSTTGFRVAGKNGKHGGPAALNSRASGTNMIQLGPRANPAGAATGNKDDANDDDGGGESVASTEPEGGDTGKETLTRATTGPTKETQTTTAAPVSTPTSPSPSASAPASPLSGGTSESSATSMTSIASTSPRRLRSSSAPGNRRVTRAGSAMILGASGGDGSGGNSSGVNQVKIIRYLKTLRPAPAAILLQEHHLGYNASREGFESAWPGACIRFTPHVLTLIPDGSPLAGHLLSSTPVVFAGAPRFDGRILRSVFRLEELDVEIINMYAPVQEDDRRDFFGLLHFNAPRPKTLRILAGDLNDCPDVSVDRVSITDRAWTPVSHWQTLLSKIAFKALDTVRHVHSCTPAFTRPHYRGRGEERKICSWSRIDYILVQCSWANRLLSASTLFDAPCSDHRPVVATFALPTSNADAEPPLSLPSTSDFISRLNPTVFDDQDFVASIPGVVDEVYRRLEGTAPLGDVYDAALRAVAVAGHARYRSTRADMRRLRAESQSVMEALEARGEHMNEAERDAYAFAKSRLDQLAVKEAQWLRIRAHVPSVDSREGQSASIRTRLNRRSRQTSIVSLEDVDGTETVDMQEALGIASRHAQSLFTPDPARGDPTNARRSLLGPIRAAKCYDDDRSDPTFGRRLPRQARVALDEPFTLLEVEAALKKTDSGRSPGPSGIPYELFKALPTYFAPKLLDLFNSIWEGGKMTASLAEGLVRLLPKNKPGANLKSLGAYRPITLRETTYKVLSKVLVARLNGVLGELLPPAQHGFMPSRRSADAGSHLTLLLEKLKSLGTEVFPEGALLSLDQQSAYDRVDHAWIFDVFEAFGFGERFISLLRALYDPETLGVRYLINGFPTELVRLLCGLGQGDPLSCPVWNITFQPFLDALVRRGIALDLQKVWPGGPRAQLTHLAFADDAVVVVESPAALSKLETLSQTWYEATNGKTNTDKTLVLPLGPNWLRDETAQALPTVQEGESFKWCGYAFFRHGDSKLFWTHVLDRIKAKTRAAGDRTLSPSGKVFYANAHIISTVLHVLSFDIPPQWFIKAAETALTDFVWGGAGRNTVARDFVFQAREDGGLGLISIGDIVHSVALRFWDAVAGSNEAIWAPLARESWRSLVVATRDFSPWGFFSSTARVEKLYRDSTRWGAVVAAARVTVPTIKSELLTLPELLSLPPRLPSLYAEGAKHAYDDADAVAKFAQIADLYWRDEGKGWALVGHRRGFWQHSKEPALQHEHVWSRVGQLLKAKALLPKTALRPARIPLKEAPRPRCFNFFGLTRPFTIRKLRRLVNVVRFPGREDRVKRFRDGTSQSDRKRFWRWLHDRFASAVEQDTHWRLMYNVTPTRKRQHTQGHASSPTCLFCGNDAAVIETVSHYFFECAYSTSFWGGVLRILFDKLGIEDTDVDPSTFTPEQLTMGLPLLRGRGRTTSRWMWVRLACAIGFQRLHLLRWRVHQRFELDKVVAPPSLPSALRAFERDFLSRAGFVPGARDWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LVE0</accession>
    <name>A0A2X0LVE0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C016g08068 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C016g08068</name>
        <name evidence="3" type="ORF">BQ5605_C016G08068</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY20474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LVE0"/>
    <dbReference type="STRING" id="796604.A0A2X0LVE0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956:SF8">
        <property type="entry name" value="ACID PHOSPHATASE PHOA (AFU_ORTHOLOGUE AFUA_1G03570)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY20474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="537" mass="57315" checksum="01A02A4783B88E20" modified="2018-09-12" version="1">MCHTHYHQSRRSVTEKSLRSAHKLPLALLFLLSSVTPELPQTPQTNVKGAVSIPKMRSAVLSFASLVAAAQLVAAEISTPFSPPSTSPTSQTTNYTGASNGTLTNGPVVAGKSFDRFIQIWLENTDFATAASSPTFQKLAGEGVTLTSYYGVTHPSEPNYIAAATGDFFGLDNDQFRALPKNVSTIVDLLEAKNISWASYQENMPYDGFTGFNYTENNYLTGNASQHYTYYVRKHNPTIICNSVAGVESRGLRHRNFNDLAADVTAGKVSQWVFITPNLVNDAHDTNIDFTSAWLEYFLAPLLQNPNFNDNRTLILLTFDENETYTIANQIWTLALGGALPSSLMNKTDDNYYTHYSSLSTVEANWGLGTLGRGDANKTMNNVYSWVANATDVSLNGLTGNSTLPLTNLTGVFPGPLNADQWTPVLAPAFLNATSPTGGAIFVDASVDRSLTSFTPINLTALGVSTPQSVDPGFDYSSGKLVLASVANANTTSSSARGTATGSSVAASTTTKSSASGAEKLVIPATGLFVAALALVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LVJ3</accession>
    <name>A0A2X0LVJ3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C016g08118 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C016g08118</name>
        <name evidence="4" type="ORF">BQ5605_C016G08118</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY20670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LVJ3"/>
    <dbReference type="STRING" id="796604.A0A2X0LVJ3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF37">
        <property type="entry name" value="ABC1 FAMILY PROTEIN C10F6.14C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="3">
        <location>
            <begin position="202"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="490"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="490"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY20670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="678" mass="77040" checksum="8074F4BEE74B43F0" modified="2018-09-12" version="1">MLQRARATYRSLVHSLPFPSSRVRSSAGVLFSRALSRSLSRSSSSSLAVTTSSSPSRNRPTTARSRSLSTRAYHSSYRLYSSSSSSAPKHPPRSLKWPRRARNSAIVVGLGVALYAWDNTYYASALTRTARTAYVGAVMALDFKLNFNPDNATAIDALHERVAHRINDLCVTNGGLYIKLAQSLAIQAAILPKPYREAFANVFDQAPHVRFDEVVKIFEKEFNGTHPDDAFDEFSRDPIASASIAQVHRARIKRKSGEQPWKEGEGWVAVKIRKPSVVIQVEWDLMSYRALLWTYEKLFDMPVSFVSREVTARMRLEVDLANEARNAEKTAAYLEKETSLKDKVLVPKVYWDWTSEAVMTADFFDGCKLTDKKQLEQWHLSPRAVMDIANGLLGAQMFKFGWVHCDPHPGNLLVRPHPSNPRKPQLILIDHGLYIPLTEEFRLQYCLLWRSLFVGDTKTIEGIVQPWGIAKEHSEMFASMTLLRPHRLNKEKGAGAEKVDGGLKERKLGEKRKEEWGEKDRPKEVSKYEQPNGLKERLRDMLQNQEQIPKELIFLGRTARMMQANNQQLGSPSNRINSLAHWASAGLEYTTSQSPRRSLTLKNVGLKTYAVETFRSLLFRVVLLFVDVGFALTQARQWFFKVVMKKDHEGFEDLLQRQISKMAKDEFGVELDEEAFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LVP3</accession>
    <name>A0A2X0LVP3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C013g07321 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C013g07321</name>
        <name evidence="3" type="ORF">BQ5605_C013G07321</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LVP3"/>
    <dbReference type="STRING" id="796604.A0A2X0LVP3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061672">
        <property type="term" value="C:glutathione hydrolase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008242">
        <property type="term" value="F:omega peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01908">
        <property type="entry name" value="YafJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000060">
        <property type="entry name" value="Related to DUG3-probable glutamine amidotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026869">
        <property type="entry name" value="EgtC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052373">
        <property type="entry name" value="Gamma-glu_amide_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43187">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DUG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43187:SF1">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DUG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13230">
        <property type="entry name" value="GATase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="2">
        <location>
            <begin position="2"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY15313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="370" mass="41153" checksum="2BBFB4EF8538F546" modified="2018-09-12" version="1">MCRLLVVKSEQPIQLSQLLTAPAHSIINQASDSRLRLDAGSINADGFGVAWYGPHDDPSTPLGPCIFRSITPAWSNSNLHRIAERVKSPLVFAHVRALIESGPPHTKSTTGALSEENTHPWSYYNLVWMHNGCISEFRKIIRHLQADLSDEYFGVPQGNTDSEWAFACFLERLSKITDPKARTIPHQLLRQAMLETVQLISSYTQKVGATEPSLMNFCVSDGLSVVSTRYITSATEEAASLFFSTGSMFEEYEPGMFRMTKADKRERIILIASEPLTFERADWVEIPSQSLIVITPQNNLLKYPIVDQFFQHHAVSVRSDRFASKKGFRWNGTVPTVNNHPPPTMTMTTTTTTTTGKGLGTQGKAVVAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LVV8</accession>
    <name>A0A2X0LVV8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C013g07239 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">BQ5605_C013g07240 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C013g07239</name>
        <name evidence="2" type="synonym">BQ5605_C013g07240</name>
        <name evidence="1" type="ORF">BQ5605_C013G07239</name>
        <name evidence="2" type="ORF">BQ5605_C013G07240</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LVV8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY15083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY15084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="54" mass="6306" checksum="85787BEB4F37EB03" modified="2018-09-12" version="1">MVSNAVHLIGQSGKNDLREDTARVLEIHELKNEMDNLFALMSERSEEDYDEKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LVW8</accession>
    <name>A0A2X0LVW8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyl-protein thioesterase 1</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Palmitoyl-protein hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C016g08288</name>
        <name evidence="13" type="ORF">BQ5605_C016G08288</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY21885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LVW8"/>
    <dbReference type="STRING" id="796604.A0A2X0LVW8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF17">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="12">
        <location>
            <begin position="156"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="386"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="543"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="558"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGY21885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="584" mass="63122" checksum="0FFE2379E514F765" modified="2018-09-12" version="1">MVGGRSPRRSSSGSASGSPVHRKATSFSSIKVEPFRSSSSLYNPGSNGGLYAIRNGQGYYHSRPGSWVRALAISWLPTPLRRLLYLHPTAYLIPCFLFFFLIASSSLSQSPDNHPLEILHELPLHPFAAFNVKCHDAPHASLVVKPEYVDDVLAGQDHKVTAIVLHGFNDRNQWTDPLKAALPYVKWIHPKGRTTNITANEGHASPAWYNIKTYHDIHEDEDRAGMLETQRQLNQLIKRERSVFEQRGETPRIVVGGFGQGATMAILSALTSAEPLDAVIALSGYVPVPSKALEIASAVRKSTPIFWGHGKKDPYFSVEAAEEDANALQLPPYSLTNVEFRSYEGLEHFWRADEVNDLIGWLRLTVQVSDPVESAEVVEDAVAQVPTPEEVGETDTIDEDSEELVDEDAQPLKAGFGRPNPGQVGGAMTPEKGAGDESDDGTALIRAPLVKPETFKVSGSGRKSGPNRLLPAKDTQADEDEDDSQASDVEGKPKLAGPGRASPLPVLPVEIDLPLPASEVAVVDSNADGHVEDTLSDLVKEAQEAEASAKAGLLDTTPMEDELQDVPLEEQAAAAAETPNPGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LWJ0</accession>
    <name>A0A2X0LWJ0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C015g07768 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C015g07768</name>
        <name evidence="8" type="ORF">BQ5605_C015G07768</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-actinin family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LWJ0"/>
    <dbReference type="STRING" id="796604.A0A2X0LWJ0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000001">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014837">
        <property type="entry name" value="EF-hand_Ca_insen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08726">
        <property type="entry name" value="EFhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="123"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="243"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="607"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY17390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="779" mass="86876" checksum="107DFB2D18EB41F9" modified="2018-09-12" version="1">MSYHVDGGHPPNHGDSEAPRPRPRSLMAINQSSSYTDTACASSSPSSSRKAAHRSAASISSLSSLSLTQNDYPSPGTLSPTLMSHSYSQAFGSTLGDRDDHTANQATTIAIRGPEGAIMDHAKMQNKVFCNWYVQRGVNSRLEPRGFEPVVNLSQDFHDGTKLIELVEALTEQSLGRYNQMPTHRVQKFENAKLALDRIKEMGVHLTNIGAEDIVDGNLKLILGMIWSMVLRFSIADISEEGSHAKEGLLLWCQRKTQGYEGVDVQNFTRSFQDGLAFCALIHRHRPDLIDWDSLPKDPRRAADNLRKAFKIAEERLGIKQWLDVEDVCNRKPDDKSIMTYVAQFFHAFSTTAQTETEARVIGNFVDNMSSLMSAVHDYERRVGQLLDSFTIAEQGWSQPLPPRISFVQLKAEQTALEKFCRTELRAWVTEHVNLATLLINIQTKLKTYGLRVYQPTEEYSSEYIATCLNSTRNAELARKQLICGEIRILQDEALAHIVELAEALSRKISVLHSKLSGLAGTLDSQLECTRMVLSSLPSLTHGLDALHAAEENLIACEVSPLVPRGTVHSHESLGFELELVASSARGRIAFIDNQIIARKASSASPEEMEEFESVFRAFDKDGDNHLSLEELEGALGALGISEINLAEMHDSNQGELVSFSEFITFLRSHSASSLQVQRSEDRLTAEKVRSCFHSAAANKVRSLVFQERSDSMKTHTMLHLSIQQGYVTELDLTRLDLPTTSVEFLKEWMPQVEVDGTEGQSEEGACYDYETFLETFVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LWR2</accession>
    <name>A0A2X0LWR2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C012g06852 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C012g06852</name>
        <name evidence="6" type="ORF">BQ5605_C012G06852</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LWR2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF158">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 12-LIKE CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="452"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="488"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="531"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY16349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="559" mass="59689" checksum="B2380C80DAA11A89" modified="2018-09-12" version="1">MARDATRHRARILCATAVILNCLTAGSIFTFPLFAPPLARTLGLTGAQTNALASASILGEYVSAGLFGALTDRKGPGATSFAAACLFGLGYGLLGSRYLVSAKMAREGIELPQGQWIFLCAYYFLAGAGTAASYFSAIIAATKSTPSRHSGLAIGLPCSIFGLSPLFLSSLAPYFTSRASELTRVKGVNEELDPGKWLLFLAGFLFLVNLYSSFTLKEIPCEEEVDLAVQDSGTGSIEADSGDTPSERTRLLPSTVVDLVRNDEDDKAPMRQSFSTLLSTPTFWLFGAVIFLATGPCEMVMASLGGIVESLLGVHTLGEESSSSSRSKASTILVALVSSPALKGASDIRALALRRLHVQILSAANTISRLLIGFLSDWLSYAAAPLVADDDSPPGSPRPASSIHPRSWKRRVQLLFHDRPPPRVSRLFFLVLSCVVLALSFFYASSSLSEPSGLWILTISVGSCYGLVFTLAPAIVRAVYPISDFGRNWGVLSLFSACGASLFTPLFGVLLDLQREKEGIAVCVGTECFEKIFVLSGVSEVLALAITFVLWKGWWKGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LXL9</accession>
    <name>A0A2X0LXL9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C014g07463 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C014g07463</name>
        <name evidence="1" type="ORF">BQ5605_C014G07463</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY18756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LXL9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY18756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="393" mass="43594" checksum="AF32853D562DC5F1" modified="2018-09-12" version="1">MYLDNLDIELLDDDLERMAPLLDLSWSTDEPLEFDTLPRPFDAWRDKFKDRGAITAAREQDYTERMRSIVISSQKWVEIYLGVDIKSQHLIVKALEVLPSLLIEEQYTPSRILGCSASLHTLLDFGQRGLEKGLVVLDPKERKSVENAVRSLAALGLDNDAAPPMTRPMLKQRNTSCSTSFNWFRVATLNGTSILSQAQVIRLPSLLRHESRQLALDLNSLIQHRRAHQCAHLKAVLLKGRHGAPTSTAQDFDPTSSAKLSEHGEVHYSVLRGLVQSMGAARLEAVSGVARSIRWTEQGTFSCFSTANETDNIGYIEDGRKEIRMQLRARQYTAFAKNPPFGSIDGNVTSATPLKIGSVVCFVLKRGMIPVSCDASNIGEEQLSIGLGSCISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LY89</accession>
    <name>A0A2X0LY89_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C002g01223 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C002g01223</name>
        <name evidence="3" type="ORF">BQ5605_C002G01223</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY31342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LY89"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12014">
        <property type="entry name" value="Cyclin_D1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="16"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="372"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY31342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="751" mass="82575" checksum="30A43199DCF2CF2D" modified="2018-09-12" version="1">MLSLTRSPTPGPPTKGPSLTTLPPELTLRCLEFAAAQAIVRVSETCRSLHTIARSELLWRQICVSIRTSDGGEPLSEPVRLGGKLVPRSKHLHPSSPPPPPPPATETDSVDRKSSAAQSSHRSDSAYLNDESITDYDGDGWWKQTSFLLPHSQHLGYWISSSPYTSRIVRLRTSLAETGTSAIPTLTITASQLIPRNLYHSLAHPPPILPHGCRRDGRDHASYYVPRRGPGSATPDRGLSVDILDPEYGWRDLFSINESSGALLSTAPYSGTSPDRFGQQLRLRLEKVIRDVLHSTGGYHNEQERSRQDADSLIRLFTGRAPIRPWPTEELVGVDLAPASTPTRRRGIFRGMNEWVLDRGQPRSVTQEVTEPRSPASSSSISLPRSVGDLADGTVPFDDPRLGSRTVVEGFHLQVRRKLTTLPGMFSRSPPRNVFGQFDPLGGPRVANAEVPYRPMRGPRGGPEILWNGGRDLDPDPHPGVAIIRAGGEVLGQPGGFMFHLQPETPLPTQPLQQEHNEEYHGEEIVRTDREEFYPIVAPSNTIKYGDTIPATVGPDGDILASSLEGLWIGTYGPHGLEFGYITVRLVASDTMPSVHPDATVYERQLEFCKVTGDANVPSGQISWAVPLSPIEEVASSIDQVNLGTIPSVRNEQLLQWSAFDPDDWNGSQEVPDWDQGTMEGWGRVAAVGFSNAGATPTQMIFIRSTETIEPPPDAPLEAETKRIDVVEEIRLRWTEMGKTAVFKRVRLPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LYJ7</accession>
    <name>A0A2X0LYJ7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C002g01343 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C002g01343</name>
        <name evidence="8" type="ORF">BQ5605_C002G01343</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY32280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LYJ7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="7">
        <location>
            <begin position="141"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="5">
        <location>
            <begin position="438"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="589"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="556"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="557"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY32280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="671" mass="75178" checksum="2CF364B343764542" modified="2018-09-12" version="1">MSRYSFTDPLPTLVAAVSHVKLSDAVKQQILDAYETDPFCQQAMSNIGSVTSDFKIVDALLYLRGRLIIPSLAPLRESILHDAHDAQGHLGDMKTYRTVQQAYFWPNMSRDVKHYVQQCDSCQRTKARTTRIAGKLHSLPVPTRPMADIAIDFVGPLPAKKGFDRVLTITDRLSGYVRLLPAREADTAAEVAARFHEGWHRLFGLPQSIVSDRDKLFTSKFWTALHKRLNIKLQLSSAFHPETDALVNKEQSNWAECLAVCEYAINSSLNVATGKTPFELVLGYTPSLAPLARVDGDDDLPSVEELLALRFQACEDARDQLAISKVRQAAQSNKKRQDEPSWAVGDLVLLDSSDRRKRLHTRKRRAAKLMDRFDGPYRIVKAQPEISSYTLQLNGDDAAVPFFHTGKLKTYRKNDTALFPNREPARLGPVDVGGEPEYIIEDIVDERIRAGKQQYLVSWLSWPSDSNSWEPAEALEDTEALDRWECRNEDEARERSRAFHCDELLYLRATASPSFDVAKFTMNQLVAYLQSLWEAITLERATTGVRRMGLRNDQVRQEQNNSAAHQTSGRPMAGLDRTPRDKALHEGCCFHCDVHGHIAADCPSKPGTSLTLAPSRPTPGPQMVAAIREYQESGDSTAFVGISSDSEEDDARWLAFQTDKEDACSFGLEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LYX3</accession>
    <name>A0A2X0LYX3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein 198</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C002g01506</name>
        <name evidence="11" type="ORF">BQ5605_C002G01506</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM198 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY33510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LYX3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025256">
        <property type="entry name" value="TM7S3/TM198-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040236">
        <property type="entry name" value="TMEM198"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31247:SF5">
        <property type="entry name" value="DUF4203 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31247">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 198 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13886">
        <property type="entry name" value="TM7S3_TM198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016143156" description="Transmembrane protein 198" evidence="9">
        <location>
            <begin position="28"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="TM7S3/TM198-like" evidence="10">
        <location>
            <begin position="76"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="533"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="640"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="571"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="646"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY33510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="660" mass="71104" checksum="5287C23895884F6E" modified="2018-09-12" version="1">MGRSGRVLPSSTLSALSALAWATLSLAAATVGHAPAPGRLLRRNPDGFTPSNQIPYGGEAYYTNYRKSPAVVLTAVAALLAGVYLCLFGKRGWRFTTGLCTALMGQLLTWIIITNVAAIDLKGIAIWGFSMIGFVVGFAVGALLWRFGIVVAGADGGLALALGLNLMVPHESNSPTWISIGVLSAVFAIFCPLLSQTYGMATCSLTGSFILGLGIDLFVEQASGFSLGLRYIFDQRHLPPDLMYQPSEVTRVFLGVMWGLTVIATVFQTWRWRQHPFERTGDAFTNLQGERTEEAACSLNARSVRSEERLRESRAHTFSMITCAGKRTSWEPQNRSETKMDHLASLGPIHMSCTSTFEGRPIPTPPGVVHHNEPPSPPSSIVSTEFARGLHSRPPTEYDHSRRIDPHDSVVLLRPIPRYAEPNPGPTPCYEETLTDTTLRPVEPVGVPGRQTPSFEGVGSAPGNPTPVGSNLTKRTSYRKPVPPLVDPQFENAASNISKGSKSPPIENGGDSSAAHEKYAFEIPMAQGFASGRRYPLDERGDDATLDDSGSETPIFGTNSQIREVGPPTDTYATESATGTRRQAEASIRQVRPVLVSRFTSTTDHLPMANGVHSPLGEPGVQFAARPNPREIVPSVLFWPEGMPASSRGKSPGVSSSPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZJ2</accession>
    <name>A0A2X0LZJ2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C016g08204 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C016g08204</name>
        <name evidence="2" type="ORF">BQ5605_C016G08204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY21164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LZJ2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015991304" evidence="1">
        <location>
            <begin position="24"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY21164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="461" mass="48213" checksum="991E298AEBDA08E7" modified="2018-09-12" version="1">MRSANLLLTTYTFFGATATFANAHADPGLLGNLLGGLGLTPQSQGLRTDLQKGIGQFQPLLSAKAFATVSGTLSTLLSTLPGGNAIASPIISALAAAQLASSQSDAAALDAAQKCLNDIVSKKGIPSGYVCVDSVSRQWSLSASSGSARLTPSLARRPLQAKNTLATYRTAFNTYLEQFVGIVLPNVVTAIQNQEKTIFDNLGLIPPANDLNDHINNAIASVVASTSGETVTAIERFEDCFAQATKDNNLQTTRRCLTGPQSGVSSLFTLLSGVTQQFVGYLPPNVVNDLINRALAVNNYYLSQAGVTAGLPLQRSVQAAIKSIAASTSGNSATLLMQASNCLSDLIMSPDPSNLKDCIVKQGGPIFTLQVLVNSIIQQAFGYLPPTLVIQLEQELAPAIAKADENPEGVDQVFEALFKTASLGPKFVTCVQALEDCINNAVLGTSNTCDLSGKCAPFPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M081</accession>
    <name>A0A2X0M081_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BQ5605_C019g08966 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C019g08966</name>
        <name evidence="11" type="ORF">BQ5605_C019G08966</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY23669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0M081"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="10">
        <location>
            <begin position="1424"/>
            <end position="1477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="123"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="183"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="425"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="478"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="564"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="700"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="797"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="975"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1050"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1147"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1276"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1376"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1470"/>
            <end position="1557"/>
        </location>
    </feature>
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        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="505"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="537"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="568"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="814"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="859"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="981"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1050"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1060"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1337"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1384"/>
            <end position="1398"/>
        </location>
    </feature>
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        <location>
            <begin position="1505"/>
            <end position="1518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1531"/>
            <end position="1551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY23669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1557" mass="159906" checksum="1D18844BE923DF6D" modified="2018-09-12" version="1">MPMQADAGRAAWPRRWARATVLLKPSQDSLTWPPIGISNAEGSPYITLAQDIRPCKWALIETHERLQLATAFSSSDIVATLSYEALGWGVGRPTRDEHRLFVDAAASEDDEGDVDFSAFIHDSTDSLRDGGAQPTTTVEGGVGSDTNSLSHQQASSSSNASTAAFLASIPNASSVLLGSHFSGATPEGSSASTDSPHHSGSPFSSVGAPTVDSYDLTTTSESTPSTSPPFASKAFFPQLPANSTQCDMSGPPSAPGKTSAVPPYTVPLDWRTGTQSGPFTVDAGGGAAAATTTSAPKQQNSTRTAPMPDMMRAALDPIDAAIYNAQLAAQAAYMQALSASLISAGLSPPSTTPGTPSALSAGSPYSQSEWIAAQAQAANYAAAFGRGGPLPPLAMQGLSMAQPYPLYNGYSRAHSHSPYASPIVPQYPSPFGTPRQSPMANPLMDPSISLPQSSNLPNRGEGRPRRTSSFIKAARGMSASTAGANGANGGAAHSRQRTAPSLSTSGAFSASPLASPSTTSPSTEFAGPNPPTLPRGSLSTKTSPAHSRAASISAQFVPVVPTPPLSRPVSPKPVASAPASASASTSAQQAGSPPPVDYDFSSLEHDLEQFSSTGFASAAAAAMSTEARTRRGHTGVGAYGVGGYGSPQSPYAVAAESTPSPKVVAEVLGQSVFASPASRTPSSNEASPIDFAALLQTSNAGSTSRKASPAATGLGSMPSPTDSTIIDDENAEALSRQDPIAAQVWRMFNKAKNTLPNGARMENLTWRLMSMTLKKRREETAAAEAEANALATMDADTLAMPPPTLTGVTISTPEAEREEAKDDVLELRSRNEAARLPKSGPVGDVLEEEARGRRGRSGPGTASASASESPENAQEDDFMDWRAKSQSRSRSRAPDAMDWRAASRSRSRAPDFRVSVAPPTVDSATATANFSRFYGDSTPVSNPPGAQTAHVQLAASLGLSATDDMFSSFDLSSTDFGGSHGSPAAPSNPSAPAIPISGTSTVSATTSNSLNSGSQFLFAAGSGGNPAASANLSAIESTLNQLIDLHSLSNSNHSKSHSSGRQSANVSPSSSLLGLAKSFGSDEANFPEVRKASGDSAYASLAQQQLRFLVGRKSSNAGRASTSTASSSAYLNAATLAQSSRPFAFAPPSGLSLARPSGTISPRDDSGHNSQPQTPLFDAPHPFSYPQSAPGPGNGFINSPIGSLYQDTPDVNSASFYDYYNRTDLASTPAGSAFTSPYLGGTSAAGQGTFDPSASMTHVNPSHLLSLLQTPAAYDSDSSLALTSPGDASRHGTPSPPDPPQAGTGAKPDASGLPSKLGPIKSSTAVPRRPKQPSAPKAQTGSNVRVSASSPDLVSLGHHAALSPILESISATSTKLPKGLGASASRTHSRSNTISVQASIPEVRPLAPSLVGTTSATPSADGGDPEVVKCLNCQTTNTPLWRRDADGRPLCNACGLFRNLHGVDRPANLNTGVIKKRNRARGPKDPSATKKSHGRSVVRRNSVGASAAPISITPSSSSRVQMRQLIGPYPSTAARAEAASASSTTHSATNSRVPSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M0X2</accession>
    <name>A0A2X0M0X2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C019g08974 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C019g08974</name>
        <name evidence="2" type="ORF">BQ5605_C019G08974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY23727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M0X2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY23727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="254" mass="26081" checksum="B54342EFB8FACDF7" modified="2018-09-12" version="1">MNVEFNATHQISPQEAVDVAVAPVLDEAVVALSSPGMTPDIASLVHDSEEAALVGSGWSSPIHAVAIPSSSSIGIGPDASASRSPVRSSQMRSFSPDSTSDSARGASPESIASFSVGTPPDDRSTFAPFSQTLSEALEQEAQKRHPSEMGPTSSPPLAAGVNKLVSPVPFSLAAGGGSLHDAAGAQISPSPSFNALAGVKDERRRLSFVSYADVINEERLAELTGAPQGGEPTENAVDLATVLDRLDLASQESH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-10-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M175</accession>
    <name>A0A2X0M175_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C018g08637 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C018g08637</name>
        <name evidence="2" type="ORF">BQ5605_C018G08637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY25538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M175"/>
    <dbReference type="STRING" id="796604.A0A2X0M175"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY25538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="288" mass="31905" checksum="9EE32CD42EC25B28" modified="2018-09-12" version="1">MKLTYFPIRGRAEPILLLLIDSGTEFEHEIIQYKTWGDLKARGENGPPNFPFAALPVLTFGHGARGGNDTKLAETGAILMFLEGKFAAAGTSPSPPDAKARLEMIRCASSFLLTRLFSLVSPTWLEPASRTHLLRSLIHPFLSSLSHHLSSSFFPPLLTRPLTNGQPGTSLSPAAATAYTTLCLIQELFPHSLGPGQGGGMMKYFPRCEQLRTSVEQRPRIKDWIESGKREVEWTTRRGGELKVIKKMADKYDRVEEVEELFGHGKKGRGERVGMEGVREEVELDTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M1F4</accession>
    <name>A0A2X0M1F4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C018g08727 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C018g08727</name>
        <name evidence="2" type="ORF">BQ5605_C018G08727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY26372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M1F4"/>
    <dbReference type="STRING" id="796604.A0A2X0M1F4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045967">
        <property type="entry name" value="HAM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138:SF1">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19343">
        <property type="entry name" value="HAM1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAM1-like N-terminal" evidence="1">
        <location>
            <begin position="239"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY26372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="618" mass="68434" checksum="D0AAC4C6B98FE8D3" modified="2018-09-12" version="1">MSLSNTSLSNLPLLNESNIEQAEMTLASLTRAAAALKEGKLPTSQQFATLVQKVLKSNLLQPELGARLTGKVGGGKLSVRGQELVESERAVLEGFVRIVLEKNSDDKDTNVTVNIWWYSADPIRSYWPSILPSLERQHDVMYQKIQRFLWLASQADFEVDADADLPDLPVPSDREIGEATRALKELFTLLLTSSQLRRIVGDIINLFRDMFADAAEQAAEASIRATKTSKQVAKTVRPGEEEKAEGKVNLNLNGDVSSKQLKKKVLRGAEDAKDDALASISKSGRQLKSYVDEKLPTDVKDVFIERFKGVVNEIKSNPDYEDSLNTIVGLVRKYAARSKVALKQAASSVEANVETNDKADSAASLFREIVESFTGDLSPVFQAADKVARDLENDSRIESLLEDAESLLDRAINDPGYITSSRAQRRAESLYDQAQELVNLNAAWKKDADNFVAEANKCLQRAANDKALVQLGDRFERLGKAFTKFTQTGFTLTDAGSMWSDLTQVFLPRILGALEEIPLPRVEFTSEEVDLVIDNVRFTSTSFVPDATHFRNHNEITVKKGYAAYASEFSTSTTLSISGLRLQAKDISYYLHKKTGWLTIEDYGMLDIKIAIASHSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M1J0</accession>
    <name>A0A2X0M1J0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C003g02428 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C003g02428</name>
        <name evidence="5" type="ORF">BQ5605_C003G02428</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY40820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M1J0"/>
    <dbReference type="STRING" id="796604.A0A2X0M1J0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF4">
        <property type="entry name" value="FAD_NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY40820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="562" mass="63848" checksum="7590128DF00E3619" modified="2018-09-12" version="1">MSPKPENQPTIAIIGGGLSGLTLALELKKNLGLENTVTIYEKHPHDVGGTWRDNYYPGCACDVPSHWYSLSTELNPDWSSKYSGQAEIQKYWQGIYKKHNLAKQTKFDSTFIKGEWDAVAQGYNVEFKRKDGSTFSIKCDVLISCIGGFSTPLDKPHGMKGIDSFKGPVFHSARWRKDVDLKRKRVAVIGNGCSAAQFIPILAEEKSTQVINFSRTPSWFAPRDQKDYSGVTKAAFRYVPGLMRSYRNFIAITSDSRFVVWWLQFSTLRHYVEEQMANYSRQNSPEKYHDFLVPKYPFGCKRVIMDPGYLQCLFRSNVELVTDGISTITEKGLLGKSGKEYEFDVLILATGFDVSEVGLGINVVGRNGKTVTEQWKEQNGPQAYLGTTIANYPNFYSVLGPNVASGTASVVYSTEAQVNYIVKMIEPMVKYGVKSFECKVEVEQQYNEYIQNRLKGTVWNGGCTSYYKLGEKVVATFPGPTSEFVWRTRKPKFENFTQTGGTVRVAARHAQKKIAKWFTLFALIALFRKFGYKRIRNEIVLWLLMRYQEVIPIINRVRGRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M280</accession>
    <name>A0A2X0M280_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tafazzin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C002g01312</name>
        <name evidence="14" type="ORF">BQ5605_C002G01312</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a cardiolipin + a 1-acyl-sn-glycero-3-phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:33731"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="ChEBI" id="CHEBI:62237"/>
            <dbReference type="ChEBI" id="CHEBI:64743"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:33732"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:33733"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion outer membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the taffazin family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY32052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M280"/>
    <dbReference type="STRING" id="796604.A0A2X0M280"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000872">
        <property type="entry name" value="Tafazzin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497:SF0">
        <property type="entry name" value="TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497">
        <property type="entry name" value="TAZ PROTEIN TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00979">
        <property type="entry name" value="TAFAZZIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="13">
        <location>
            <begin position="42"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGY32052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="291" mass="33610" checksum="4435E055B0B02483" modified="2018-09-12" version="1">MSMLIPTAAGAVSKVFLKQWCNEVRVTGLPTFLDKLNSDRGVLTIANHISVDADLVLLTQLHSVDEPFMWGCLPISLFMDTRTTRWTLGASDMMFTGKWDSWFFSRGQVMETLRGKGIYQKAIDRAAKKLNDGQWVHVFPEGMIKQDTLNELRRFKWGISRLLFETDPERMPHVVPVWIKGFQEVMDERRGWPRMLPRPGKNVSIMFGNSINSAIDPLMAKYRTIFPNPWRPATYGNDVKEDLRVEPEGLAAMRSELAARIRDELMKLGNDGRLEKMLEQKPNRIRWNRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M2S4</accession>
    <name>A0A2X0M2S4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C002g01532 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C002g01532</name>
        <name evidence="1" type="ORF">BQ5605_C002G01532</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY33725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M2S4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY33725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="196" mass="21594" checksum="F68CF0782F549FBA" modified="2018-09-12" version="1">MPRIHFEGGTSYRKQARRFIGSVRAEADRIAAATAGRIHFVIVFDHASARPALKALSPDNFQRRSSDRNTDPTTEWVTNFGAQGELALAGHVLDMSSEVTVVISAHEADPLIAANTRLGDSDFLLMIGSERARYRIIPSVKHRVVRVIDLEILERQGKFPGAEGRFVAGLMMGCNYLPTGIKSLRSRQAPSGELEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M2V5</accession>
    <name>A0A2X0M2V5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01300 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01300</name>
        <name evidence="2" type="ORF">BQ5605_C002G01300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY31995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M2V5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY31995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="388" mass="42523" checksum="51FC87AEA41CFEF2" modified="2018-09-12" version="1">MDPGAILEKDFVIQTSSVRSAIGFVCKYCGSGRLRRSGAIKHAASGKHQANVSGVGQGRGAVSAPALAKYTFLDSTDEQGVDSTELGCEQGVWEQDTYQTPSFDTEPYAASEEDSDDKHECSEIELVNSNPFDGDAGLANVQPGSDELPGDAFEPSRVETRSPPRYRRGARNSSTVPPPDHPFYPFPDPLMMIIVLFMRSLKRRVGVQELEDLLDFAAATGTTGLPAASTVRTFLDKLEKEVPLFRAIEMKKDKDRSVYVVSPRDYIASTRGAHPPAQHFARPSTARAMEHYPVLQPAHVDSAHHSRRWLSDLPPRFSAPMTRVRVVYSFVDYFVDEIVTLKGSTQYGFVERFVSFKGEVHAIVCSATVAQGSRIDVVVPAAGRGIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M420</accession>
    <name>A0A2X0M420_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS23</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">37S ribosomal protein S25, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C003g01863</name>
        <name evidence="9" type="ORF">BQ5605_C003G01863</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS23 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY37695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M420"/>
    <dbReference type="STRING" id="796604.A0A2X0M420"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016939">
        <property type="entry name" value="Ribosomal_mS23_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37799">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37799:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13741">
        <property type="entry name" value="MRP-S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="34"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="241"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="257"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY37695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="329" mass="36543" checksum="072EDE569A727054" modified="2018-09-12" version="1">MNSRKAARTIPSTISRLLKSQAFLKSPPAAFEALLSHPPPPSLIRTLPSRPNEDLPLIHRERTSPKPSRVVQALPQPHTNRTPPRRPNTKNPKPLPIVFPEDQIRQQFFLDHPFEAYRPKDLNELETVQRDAPGPQGKQWTELRQRSIVPGPDDVIAFTLNLIEAHSIPLSKAYTHALSQYRTLKAEHEIATSSAIAEARAHGAYFFGEVERGLVSEERALDEWKDAKEIQAQLLEGESIGAKLGPGGGSAPMTGASSLSSSLTSTSTSVEGGMPWGDATRSNRVEEEPTHTYELTGGERYLERFEERFLNQANLAAQERAQQRRDSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M4K3</accession>
    <name>A0A2X0M4K3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C001g00863 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C001g00863</name>
        <name evidence="7" type="ORF">BQ5605_C001G00863</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY50206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M4K3"/>
    <dbReference type="STRING" id="796604.A0A2X0M4K3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF16">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY50206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="285" mass="31187" checksum="11A259897C260D4C" modified="2018-09-12" version="1">MDDSPVKARFLTPHERLQAVERLRANQTDVASSEFKLAQIKELILQPSFWIFMSCTFCVNVGTSVSSVFGALILQGLVGLSSYQSVILNVPFGAIQTIIIVLASWLAYRFKVKSIIMGVFMVPVVVGVAILYAVPHDKAHRSVLLVGYYLIAFVSSANPLIVAWMSSNTGGQTKKAAIFTAYNAASSIGNIAGPYIFQSKDAPDYYPGLKGALAVFSILIGLITLQGFNFAWLNRKKAMQRAANGQTSVIVDTSMNSKFEQVEAGFENAFLDMTDRENPDFVYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M534</accession>
    <name>A0A2X0M534_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g02132 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g02132</name>
        <name evidence="2" type="ORF">BQ5605_C003G02132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M534"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY39048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="96" mass="10769" checksum="82569DBFA331833D" modified="2018-09-12" version="1">MGSLRHTPPPPQANPASLVGKEKEKDTKTKCKKFTRRRKKKAADTIIESGATTGPEEGAKKKKKKNKIRSWPVRERKKEPVLSPKSEAFVKSSGYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M6F1</accession>
    <name>A0A2X0M6F1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">BQ5605_C001g00138 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BQ5605_C001g00138</name>
        <name evidence="16" type="ORF">BQ5605_C001G00138</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY44286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M6F1"/>
    <dbReference type="STRING" id="796604.A0A2X0M6F1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016817">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013967">
        <property type="entry name" value="Rad54_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08658">
        <property type="entry name" value="Rad54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="302"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="657"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="13"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="209"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SGY44286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="925" mass="103879" checksum="02878AA5C977BCEF" modified="2018-09-12" version="1">MHWDVRRSFLASIKAGGDPSTSDSPQNAAALRASGGGFGTPTLKPFKVPASITSTRSRQLGGSRSKSHIPGQKREREYDENTFYDDLTTSNEYDPLAAKKARKEAKKAAAEAKAAAEDDSDDGKKGRGGFVDRYVPPSAPRRFPVFRPKTPEQSLNKGFSIPGMKRKGQLVETRPSNLPLGTRRVGDVLPRPLFDPLEDHAVVLWDPTIDDREAEREAEKQRLLQLERDNADDAELARAEADAEIERRKYHRSLAEILGIVKLDADAKKKMKVPVVIDPRVGKVLRPHQVEGVKFLYRCVTGMTDENAHGCIMADEMGLGKTLQCITLMWTLLKQSPIANRPAIDKAIVVCPSSLVRNWANELGKFIHLDFVSERGCSRHDAAPTVKWLGEGAVSPMAIDGKTSAADNLAQIRQWCSSKGKSVVTPIVIVSYERLRSLTDELGQTEIGLLLADEGHRLKNSDNQTYTALMSINCKRRVILTGTPIQNDLNEYFSLLSFCNPGYLGTKQDFHKCYEMPILRGRDGEATEKQQEVGTEKLKELSTKVNKFIIRRTNDLLSKYLPVKYEHVVFCALSPFQLALYQRFMHAPETKKLLRGQGSQPLKAITILRKLCNHPDLLDFDEDFPNVEDLFPPGYDPREKRSRYKILQTELSGKLAVVDRFLEKMRRDTNDKIVLISNFTQTLDVLGQLCSTRKYGFLRLDGTMSTDKRQKLVDRFNDPEGKELVFLLSSKAGGCGINLIGANRLILFDPGQSRVKYLEPVGSSIVTGPHHAASADWNPASDMQALARVWRDGQKKNCFVYRFVATGTVEEKSELCSHFFQRQSHKQNLSSCVVDSNEDIERHYSGDNLRQLFQYKESKCETHELFKCKRCKNGKQMLKSPAMLYGDTSTWNHLSNACLANIHDDLLRAETGLDTVTACFQYIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M6Z6</accession>
    <name>A0A2X0M6Z6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C007g04370 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C007g04370</name>
        <name evidence="3" type="ORF">BQ5605_C007G04370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY60010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M6Z6"/>
    <dbReference type="STRING" id="796604.A0A2X0M6Z6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990113">
        <property type="term" value="P:RNA polymerase I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990114">
        <property type="term" value="P:RNA polymerase II core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990115">
        <property type="term" value="P:RNA polymerase III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23157">
        <property type="entry name" value="Prefoldin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011599">
        <property type="entry name" value="PFD_alpha_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00293">
        <property type="entry name" value="prefoldin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674:SF2">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY60010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="203" mass="22477" checksum="1864DD97011E01F1" modified="2018-09-12" version="1">MSTPSDGPTPSQISLTDLSLEQLHKVRQQLDQELQHLTNAFQELRLAQVKFAAALESLDSLKKANQSEDFCDWKNEGRKGGGGPLRVELDYRALLGEPCTTYDHSNKNILIPLTSSLYVPGKIKDSEHVLVDIGTGYYVEKTTKQAKTYYNQKNLTLRSSLATLKSQIEKKEDNMRAAMSVYNQKVAREGAAGGAGGEGEEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M8X1</accession>
    <name>A0A2X0M8X1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C004g02803</name>
        <name evidence="8" type="ORF">BQ5605_C004G02803</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasmic vesicle membrane</location>
            <topology evidence="1 6">Peripheral membrane protein</topology>
            <orientation evidence="1 6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="6">Cytoplasmic face of coated pits and vesicles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the clathrin light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY67748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M8X1"/>
    <dbReference type="STRING" id="796604.A0A2X0M8X1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000996">
        <property type="entry name" value="Clathrin_L-chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639:SF7">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01086">
        <property type="entry name" value="Clathrin_lg_ch"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="30"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="152"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY67748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="336" mass="36238" checksum="96AABB18EBDC130E" modified="2018-09-12" version="1">MDDFFNPPTESSSSDPTADFLARERAALGESFGDATTTGAAASSSAKDYERSASAFPDLDVPGAQHDEEDDDDDLDFLGGASSAPVGAPTSNETGAVSVTNHTELAAFEQDYPEIELPSQQVSPSSKLDRSIVDHTDAGSLLSLIASVSGMRVTPQPTQPNPTHLIPSRQLTNRSQSNGFNSSSNKNNLFHSSQSPSTPAFQPGTAAPASEQDSEFIQSWRVKQKEEIARREEASTAKREETIVKAQHAIDNFYKEYNQKKEKNIAANKEEEAAFNAAQTDALAKGTTWERVCALVDLNDSRSKTSTKSKNDLTRFKEVLLSLKREGENAPGAAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MA28</accession>
    <name>A0A2X0MA28_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C005g03182 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C005g03182</name>
        <name evidence="4" type="ORF">BQ5605_C005G03182</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY72562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MA28"/>
    <dbReference type="STRING" id="796604.A0A2X0MA28"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045013">
        <property type="term" value="P:carbon catabolite repression of transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051362">
        <property type="entry name" value="WD_repeat_creC_regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107:SF16">
        <property type="entry name" value="AT02583P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="163"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="670"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY72562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="798" mass="84200" checksum="57C9C80D1F94E821" modified="2018-09-12" version="1">MADSNAPPHSWFAPPEGAYTLVSSLSVPSSSSLNSATAHFTQQPGVSAASVLLPAGSDPPVFIPPPLHGCKMTIVEVQMVLPGSKGTVNPAAQAQAAAAAAAASTSPMMVPGASLHSPALNNNNNDSHFGFGNGVASGSLGLDTSAATLAGAGLGTSGGAGMVPGSATSTGPSTGVVSSLTSPTLAERGGFSPTPRRKPLGSSFSIPTLSSLAGGGDAGSSAGGGNSGLGGNGGGSNSRPSRPFRGTSSSFVRSWEGLPLQGATLKAIAEAGQGRKTLFGFYTYGKGVVWCEIGQGRPKEAIARVMFSIAPTCVDVNRHTASHAQLDVLVGFCNGDIFWFGRSTPLDFYLRAVPGSILIEPPDIFLPRADPFLAKYTRLNKGGVITSSSITSIQWLPPSAAYSTSENHSNLFLTSHADGTLLVWDKDREDWSGFVPTPVPTGLNLRSVHGVGAASGKENDWDGTQIKHAPSDAGDLAGLGDIIVSRPAPFDKKGQATKFNPVSHWRVSRKAINCEFNRNRVTQRYLAAQTRLRPWRYLSSHGGPAAFAFSPDLQLCATVGNDGCLRIINATEEKLLDTFASYFGALNCVSWSADGRFVVTGGQDDLCTIYAPLEQRLVARCQGHSSWVTGVAWDPWRSDERTMRFASVGEDCKLVLWDLSSAALTRPKSHVNADTVASPMSQAQHPHARRLSLSSQRLESTGHLPISPNGTSDRTSPVYHPSPRRDDVAHLQPVMVKTLSHDLFSNVFFLPQYLLTVSRSGQIRQYDRPPEREDGYGHSIGLSGEFASSVVALDRRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MBK3</accession>
    <name>A0A2X0MBK3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C010g06062 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C010g06062</name>
        <name evidence="5" type="ORF">BQ5605_C010G06062</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MBK3"/>
    <dbReference type="STRING" id="796604.A0A2X0MBK3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053065">
        <property type="entry name" value="Archenteron_Induction-Rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024382">
        <property type="entry name" value="Vps3844_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36853:SF1">
        <property type="entry name" value="DUF3844 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36853">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12955">
        <property type="entry name" value="Vps3844_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015876688" evidence="3">
        <location>
            <begin position="19"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="519"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar sorting protein Vps3844 C-terminal" evidence="4">
        <location>
            <begin position="453"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY14100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="565" mass="59587" checksum="6FE6B5A2E3A33AD8" modified="2018-09-12" version="1">MQLFATLLLASTTTVALAASSSTAAQLRLSPDPSASTRGASSSSGGGEVVALTAQQANAVLAHHLGVAQYERLPSSSSSKGNVDDKWQAALGVGQPWTTVEGQKVVIVLECGQYGCQGQWRDGPTPTTRGYTVYDTHLWSPIATPLTDAIPSELSQSQPFELPSLPVHTWTSAVSLHLHRLAASLGIDPKSSKAVLGLEQLTESIKSVAGWAGWVGEELGSAIGWAPLKNNFKAAVEPVRSSLGLLTDVDLLDKSSATLVTELESLSNMVESLAASAQSNDNGPQAEKPQIVALHLKGLKVCRPKRDRNLQSMLKYCSMFEWPNLQEVAAAHSPSSETYQRAATLLRSTLSATLAALRQAAATDEQPTVLLLTLPPYSPPLLRRRAPFLAPFASSPAIPGQVARRGAPMHLPHQVKRASVFVDHSTTQDGRVKRAPSDSGKPRQPVVPSHYRCFESEAELNNLTASCLGRGVGVKGVSAARNGGTADCWVCSCGKTTEEGKTKSWAGQGCEKEDLSGDFVLLFFSGVGLLGILFVSVGLLYGVGNVQLPGTLASVNGAGVGSKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-03-27" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MCB6</accession>
    <name>A0A2X0MCB6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C007g04874 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C007g04874</name>
        <name evidence="1" type="ORF">BQ5605_C007G04874</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY64143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MCB6"/>
    <dbReference type="STRING" id="796604.A0A2X0MCB6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY64143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="89" mass="10049" checksum="49552ED879350515" modified="2018-09-12" version="1">MICGPIELKGDNQGAIALTMENPVFDDRTKHLRLTEHFVRERVREGDIVVNYLPTAEMLADMFTKALTRPALEKHRAAIGMLERGEVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MCZ9</accession>
    <name>A0A2X0MCZ9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C013g07374 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C013g07374</name>
        <name evidence="5" type="ORF">BQ5605_C013G07374</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MCZ9"/>
    <dbReference type="STRING" id="796604.A0A2X0MCZ9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="16"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="494"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY15464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="562" mass="62493" checksum="1905A81F0BE90EE4" modified="2018-09-12" version="1">MASTSGSLPPLVILGYQLREQIASGSTSRVYRARHQSPNHAHPFAAVKVVRLDDRVHDSIMQRKQLVREMRIHETLKHGNVLELFGGVSRMQDSDEQNGWPKGLYLCLALADGGDLFDKIPPDFGVPEDIAHLYFTQLVEALKYLGRQGICHRDVKPENCLLDAHGNLKLSDFGLATVFKYKGQTRLLKDRCGSPPYAAPELALVDPYAGEPIDVWSAGILLFTLLVGSESLFSFFISFRCPDPSSALLMRFWDLDTPWDEPTRKSPEFVEFVAGRFRSQEPWRRIGAAPMDFLLRLLNVDPSRRLGLDQFGLHEWYRRENDLLGPDRTTVVRPAELAKRLTDALHRTGWLGAPSQAYVTATQASQRGQQAMSMTFQGSIQLYSQLSMAPTQRSNPHLTRFFSTLPLETLVQYVDQAFSALAQHSIQQSSSSSSPSSSALHASAGLKHEIISMIAPTSTTTGNAPRPKPMARFKFGMKDRRGEKLTGSLSVTESVLPDLNDDPSSNAGGMDVDDEDAKIGAEDRGTKGWDVVMWKKSGDPMELKRVWKLLCSFLPDGTVFAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MD60</accession>
    <name>A0A2X0MD60_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C008g05353 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C008g05353</name>
        <name evidence="2" type="ORF">BQ5605_C008G05353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY80305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MD60"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015919351" evidence="1">
        <location>
            <begin position="19"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY80305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="150" mass="16527" checksum="8BCC42F8E42B3143" modified="2018-09-12" version="1">MRSSIIVLFTAMVGLVVAAAAAAGGDSHQHPGQSHTRGKKKDAQASKQCKQCMEDCSADCVQAMPLLLRNPRGDASRTLTKYRNNHDTALQWLISLYQQCSSQVRFQPALFLPFRSPSPHQFLNDCSAPVIRIGPHGQERETVQLPELSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MD82</accession>
    <name>A0A2X0MD82_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C009g05547 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C009g05547</name>
        <name evidence="3" type="ORF">BQ5605_C009G05547</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY82139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MD82"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY82139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="502" mass="55472" checksum="78EC28BFCBF0DBC5" modified="2018-09-12" version="1">MPFMREKASSNELHGLMNDNSPMLSHGEDDGEDGYHHALPMHTNDDGADDPISSSTRGTMSCCSCGASSGLSLSRRSRDGLLSSSSSTGTGLRMFIFFFGLIAGLAVLFQYTKQPAWSFHSKTSSSGLNRIAQWGPAPGKDVQGVQEIFLGNQRVAQRILIRDKTDREGLGSQLNHIKGSMYVAILVGDRLFVTEWYSVLTFPSHSSRFSHVCRILAKALEATFVLGDSYSHHHYSTSDMINGPIFRDPVTARPPVYVPLGQTCALSDHLPYKKRQEVIRGWCLGDQNDRRPMQRVGYSLAKRNCSIIIDDVGRDFYSDLSLCYTDVLRERLGGIDDRRNTRPDGSGDAGALTVGIHVRWGDTAHSDNATEFRGSMPTASVNEIIHEAQKRFKRLDIRIAMESHNDHVLSGFEFDYTLIDSGDVMADLHALADNDLLLIGSSSFAVVVHMMAAPDGLTILDGNDRARKFPGTQRTFFGTFEAGFHPSMLDSLPQRFPELELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MDN2</accession>
    <name>A0A2X0MDN2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C005g03321 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C005g03321</name>
        <name evidence="8" type="ORF">BQ5605_C005G03321</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAM50/omp85 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY73837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MDN2"/>
    <dbReference type="STRING" id="796604.A0A2X0MDN2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.50">
        <property type="entry name" value="membrane protein fhac: a member of the omp85/tpsb transporter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815:SF18">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY COMPONENT 50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY SAMM50 PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="domain" description="Bacterial surface antigen (D15)" evidence="7">
        <location>
            <begin position="259"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="46"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY73837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="576" mass="62185" checksum="5A4AC7A758808287" modified="2018-09-12" version="1">MSDTSSPPPAPSSSPPTRTNPSEHAKQLLTPIDVSVPPLIVRGPLIPTSDPSSSSTSIAPTSADAVPPTNATAIPETEATTTSSIRIQLTDQQMHDQSRWTEQRIQRKMRGEYERAGQQLSELVNESLDTPLRLNSIRIVGAKTTRSSFLSSLVAPFLPEIAPPSYLQAEPTSRPTSSDPPQTLASLLNTTRELSTLLSQFDIFRQIDAALEQSPSVLAEPGDVDIVLRVKEAPKYFLRTATDVGDGEGSATATARIRNAFGGAEQVEGNIAFGTRTKSAFQLRVDTPINASPNSRAELAVFSANRDLSYYASCGEYTKGAQAKIRTLTPFGLSEFSYEAVLRNLSDILPKASMSIRNAAGPSVKSSLSHTLTRDTRDDLFAPTQGSFLRFKQEYAGLGGDAQFFKTETETSTSRALPFCPPGWTLSFGSRTGWLQPLNASRTSHFIDRYQLGGPTSMRQFRPNSLGPKDAADHLGGDLFWATGLSLTVPFTPKPHWPLKVHTFLNAGKLSTFDPQQGCMGNLKGLVKEPSVSVGLGLMYRHSLVRIEANVGVPLAMGKQEGGVKGLQFGLGMSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0ME54</accession>
    <name>A0A2X0ME54_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C005g03491 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C005g03491</name>
        <name evidence="8" type="ORF">BQ5605_C005G03491</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY76448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0ME54"/>
    <dbReference type="STRING" id="796604.A0A2X0ME54"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF48">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G01000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="57"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY76448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="506" mass="55491" checksum="5947EC51A0D83CE7" modified="2018-09-12" version="1">MQHSHDTEKGSSFVQERHQIEEVALAGHAATDIHGHSLVVIDEKAEAALRWKIDIRILPTIALLYMFCFIDRANIGNARLAGLEKDLNLTGQYDYNILLTAFYVAYVVFEIPCNYICKIVGPGKFIPVLSFCFGLLSFAMAFVKTFSAGIAVRFILGVAEAGVFPGMVFYLSRWYRKDELGFRLALYIVCAPLAGAFGGLLASGLLKAPAFGMIHTWRMIFFAEGIVTMGIAAISYPLLTDRPETAKWLSAEEKALCAARTKSENVGSVVVVDAVKSKVYMSGMFNANSLVIALIFLLDNITVQGLGFFLPSIVKTIFPRKSTIELQLRTTPPYIVGAVISLLLPYLSWKTGRRALWMAVSAPLMIIGYAMFVASTSPHVRYAACFLIASGAFSFGSFCNTWAAINTTSDTARGGAIAITVFGGNLGGLVATWSYLSQYAPDQIPGNSLNLATSSAILLLTLGLWAWQKRENTRRDEGRMDHVLEGKSDDEIAMLGQHHPGFRYRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MEF1</accession>
    <name>A0A2X0MEF1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C005g03581 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C005g03581</name>
        <name evidence="5" type="ORF">BQ5605_C005G03581</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MEF1"/>
    <dbReference type="STRING" id="796604.A0A2X0MEF1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031567">
        <property type="entry name" value="CRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008828">
        <property type="entry name" value="Sin1/Avo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031313">
        <property type="entry name" value="Sin1_PH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13335">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT MAPKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13335:SF1">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT MAPKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16978">
        <property type="entry name" value="CRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16979">
        <property type="entry name" value="SIN1_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRIM" evidence="3">
        <location>
            <begin position="595"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="domain" description="SIN1-type PH" evidence="4">
        <location>
            <begin position="943"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="299"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="553"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="393"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="576"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY77218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1080" mass="115967" checksum="50586CD00B4CF230" modified="2018-09-12" version="1">MSLLADQDYFIHALRLSYLRHVLPAHAPHASSIPGTGSYNLIAFDPTTLQTSPYIVASRTHDHALWPELSNGRSSPPLASTLARSAAASAVQSPESSEVGMGNDSRRRGATGLNYKETIYGKSGAGTGPGMRVGGRQRSTRGRRATTQVAPMEPVDKWDDSVDMVDTVGAHSLRRSRSLEASLHRRRLEENTLHNPTHPQQQASPPPVVIHSPVATPYGSRTNRHSGSSLSGQILVPAHLDQVYSSQLSHIAPASPESVRIASPPGVEADLPSSIRVTRFAIDELADSGGDLQQVDAPHLQSTRETALVPSSEDAGSESVGELSLSSTGPRNASVASSGVSLFGTSRLGSNDGILGPRDRSDSDSSFPSPAPPETPAMHDFNKADTFSQVIPPISPPPPRSPYPSSPDAPAPVPLSPTPGAETPAPAPPPQFVISARFMKAPRERRRVNISGRVFVPMAEPVHEEDPPTAASVAPVIAVPESVEKPKPPVLEIPESTSPADTRKEDSLNVSPTIVQRRGSGPPSLKIDTALASKPASAASSPIIAATEANPRLSPSANRRAHPIRQPSTGLTFGKRPLPSQLSSSTTAASAPPARSNLTALLGATSGSGSGSNPFSRLYAALISRASDALKLLLYFPDSDKPSTPLKIGVKQDLTVEEVIGAGLWAYWEEGREPKLEVEEEGEEEETIRWNLRIVEEDGEVDDDFPALDRTRAVSKFSFGEFAIVKATGNQVNDNLAKQATITRRPSPKMAAPKGPTNMLTLQQGHQVVPMSPLSGPQLSATAGVSSTLAIGVLLRIRLPAAPGQGVESINTTINVPGDMYMNDVLEHVCKKRNLENAREWAFTVRHRGSEIIVPLDRMVESLGDNHELKLVRRTEIGGLRGAGQINTPLVGEMNPSGEYFEVAFGCLSEDCLLIPLWAPFAASLFRRPGQDAYQSASELAATYRRYSVMRKLGVLGRHPRIIAIDGDYIHFLPSDSRGDVFSAGRTTSFHISMLRACQTSRRSNLAFKIVVQKDRLEKRYDFEAESVKQAHEIVQNVRTLMNSYKMEEATRQQQLQGALMGVVGTQVRLGTSSVGATRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MG88</accession>
    <name>A0A2X0MG88_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C008g04931 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C008g04931</name>
        <name evidence="7" type="ORF">BQ5605_C008G04931</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY78738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MG88"/>
    <dbReference type="STRING" id="796604.A0A2X0MG88"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15502">
        <property type="entry name" value="PHD_Phf1p_Phf2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="347"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="500"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="583"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="681"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="72"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="190"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="226"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="259"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="500"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="532"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="544"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="593"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="624"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="684"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="727"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="767"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY78738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="779" mass="82095" checksum="2D5CB814B522E1F3" modified="2018-09-12" version="1">MDPFGATSNDGGANGAGASSSLDFEENLHDIPVGLVFDGQQQQQQQHATSNAHSTKPNHPTTLDIAVDPSLSASSSTSAQGSTTAGASAQQQQQQPSYASVVAAGALAAPAPAAATAPAPAPGAAAHPTQNGLASSAPTNGTNTTPGASSSSNATTSGGLTAQAQVMPPLVQSGVPGVPPKRPRGRPRKNPGVDTRPAAPRAPAAHITAAAAGTSSGAGFAAGPKPRGRPRGRPRGSRARGGRGTATTRPAGKRTRPDSEDEDGEGSDDSDFLNDEARRQAGYTGDGSRPLDPSEELPDDFDASSGNRPKAAMTKFGRRVQKPKSFTPTTKPTVHRRKRAIFNPDTFLMCQKCSEGHSPGRNRLVICDSCARGWHQSCAEPNIQDSVVDSDLSWLCKQCDAKLAAREQILDISQGTWSASPAFSNEAKREWLETRPLHSLVEYILSIEQKYASKLGSTSLEIWPTDLDEKVVAIKAKREEKRRVEEKEAAALAAETSAAVEAEAAAPPSAAEASAQPRARTLASKRSEIDQQEPSAPTPAKTNATTQSAAPAAQTSAPAPVTQVLSPQIPAPVPVSHQGLTAAGALPRHPYPHATPTPPPTSTQPASQAARTVLPPIHAARPTQAHQSQNIPVQQNQPYMRPPSASDHYGVPGSTQHHPSHQQQHHAQNVLSPRLNEHASAFVPQQQQQQQPQQHQQQQPYMSQQHQQAQHRGGPYHVPQNSFGGYASQQGGWNQQGNAGQHHGSAPQGDYYIIPPPQQQGQQQQQANGWPSRQPGSYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MGP5</accession>
    <name>A0A2X0MGP5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C017g08509 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C017g08509</name>
        <name evidence="1" type="ORF">BQ5605_C017G08509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY20177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MGP5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY20177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="68" mass="7673" checksum="4A31C0D285179816" modified="2018-09-12" version="1">MESDLDEVALQDYNDYEHSGADDEEARAYNLIDRGLATDLVVSVCQGFEYFIVGCFSRGVDLSWTDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MGZ6</accession>
    <name>A0A2X0MGZ6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C033g11197 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C033g11197</name>
        <name evidence="2" type="ORF">BQ5605_C033G11197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000066">
        <property type="protein sequence ID" value="SGZ02235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MGZ6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016083619" evidence="1">
        <location>
            <begin position="21"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ02235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="68" mass="7329" checksum="772D5B79CB667C44" modified="2018-09-12" version="1">MKASLLSLVGLAFANTVVQGRVNSPPPPFPLPPCLVRCATNYIACVQPCKPPSDEKCRTHCDNVYVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHF0</accession>
    <name>A0A2X0MHF0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BQ5605_C009g05733 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C009g05733</name>
        <name evidence="11" type="ORF">BQ5605_C009G05733</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDE2 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY85004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHF0"/>
    <dbReference type="STRING" id="796604.A0A2X0MHF0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053822">
        <property type="entry name" value="SDE2-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF1">
        <property type="entry name" value="SPLICING REGULATOR SDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22782">
        <property type="entry name" value="SDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SDE2-like" evidence="10">
        <location>
            <begin position="196"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="274"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="293"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="365"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY85004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="379" mass="40112" checksum="5AFC04A4878C4E85" modified="2018-09-12" version="1">MTAENRSGELGSALVGAQIGSRPCGANPEAGRHTSLLSLSFSLSSSASALLLHVQLHPAISSTRILHRPHSPRLIKSFLHPSTERLAATADLKSPTSQPFSPPSTHSSTSTTMLSVLISTYTPFPSTLSLTLPESTTISSLQTLLTPYCPLRQQSLSSHSVLVLKPTTTLSSLTSISNTNNDTSPLFLRLSVRLPGGKGGFASQLRAQGGRMSSNKATNNDSCRDLNGRRLSTIKEATKLAEYIQAAPDRLAQQKKEAQAKLDALNAEIERLDKGIHSKPSTSASSSASASGSGSGSGSNGGGMTAGQKRKLEESKFVKESKELNEGVRDAVKLAMMKKRKKNKTVETTEAVPATTSGSSEEEDPGKGKQKEETTVETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHL7</accession>
    <name>A0A2X0MHL7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C008g05371 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C008g05371</name>
        <name evidence="4" type="ORF">BQ5605_C008G05371</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY80377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHL7"/>
    <dbReference type="STRING" id="796604.A0A2X0MHL7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003285">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY80377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="150" mass="16991" checksum="BC969655CBE496AD" modified="2018-09-12" version="1">MVDGKPINLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPPSFENVRTKWYPEICHHAPNIPLILVGTKLDLREDADTINKLRERRMAPIAYQQAAQMARDIGAVRYLECSALTQKGLKTVFDEAIRCVLAPAVTEKKRKTKPCVIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MI24</accession>
    <name>A0A2X0MI24_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C039g11817 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C039g11817</name>
        <name evidence="1" type="ORF">BQ5605_C039G11817</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000060">
        <property type="protein sequence ID" value="SGY90595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MI24"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY90595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="86" mass="9344" checksum="84C26F295E7DBB34" modified="2018-09-12" version="1">MAHELPKLVRTVKAGVSRYLLLRESTTSGTEVETWPNERKGANRRPTGALALGGAVEVEVEATTTVCRDLLEGRASDVMLCEWTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MI44</accession>
    <name>A0A2X0MI44_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C030g10802 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C030g10802</name>
        <name evidence="5" type="ORF">BQ5605_C030G10802</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>alpha-D-galactosyl-(1-&gt;3)-1D-myo-inositol + sucrose = raffinose + myo-inositol</text>
            <dbReference type="Rhea" id="RHEA:20161"/>
            <dbReference type="ChEBI" id="CHEBI:16634"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:17505"/>
            <dbReference type="ChEBI" id="CHEBI:17992"/>
            <dbReference type="EC" id="2.4.1.82"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolases 36 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000069">
        <property type="protein sequence ID" value="SGZ08560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MI44"/>
    <dbReference type="STRING" id="796604.A0A2X0MI44"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047274">
        <property type="term" value="F:galactinol-sucrose galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008811">
        <property type="entry name" value="Glycosyl_hydrolases_36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31268">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31268:SF32">
        <property type="entry name" value="GALACTINOL--SUCROSE GALACTOSYLTRANSFERASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05691">
        <property type="entry name" value="Raffinose_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGZ08560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1031" mass="112944" checksum="6FAE1BA657FFE022" modified="2018-09-12" version="1">MSFTPALGATEVVGLSADTKAFYFTYTGSRSSPGIPEVWTNLSGAWTALAFATVPSPSSTEAQADVHVASFDLSDATLGKYEFTYRKRHAESEYEWLGASGANGTIEIVSTSATAPRSRRKVELKTFALQDGESNAIESFDLDIAAQDWCEGVVWERSEYVRLFICSLFVEPGLTVFHNFNFRRIWFLTRQLHSGSPISSLSTEFEGQLLFLRGKSTSESPTPPILVLFPFTTDQVMSTIRGGEDKVWLRCMRDTGAPGVQGHVVVGRGVDGDLEKLVAECVKVAENTLSGDLDQAMVKAPKEAEPSQGVRVCTWNALGYQAYKLSDVLKWLDVLLSPSTSSPLFAASLDTVLLDDGWQDIKQAPGRPGRTQQTLHSFGVRSTWYDVASDARQSSTSNTSPSDLAASPELADAVKQIKAKGIQRVGVWMTIAGYWDGLEPHGPMARYDLQRWNLHSDYWDEAIALWYVPSIGRLEDYYGDYFKSLKAAGVDFVKVDDQAHPDYLVSGGTDDVGDLRHAMHRAMRKMSNEVFGDGTTIHCMAGSPRIWGGALALRKFNDTKSLVRNSDDYYPDQDDSHRWHIFLNGMNAILTRALEFVPDFDMGEELHPWGQDYHVPFRSFSPAPTYSTDLMTRPLHPQKGWSAALAKTKQGGAGLVKTTNRVGAGLEGRLNDDVMGEGVGQAFVVALAFPEAQGAHLGAWNTRSNEAHAFTSINSNDVVEALGPLKATAPVALYIAGHDWVSWIRPNDLVLTQRLCATPLVTINVDAKQSQMVTVAQSYTVDGIKIACLGLTDKTTGLAAIKEIAVVQGLLSTLKTASTSKAAPPSTKTCSDLVASSASNEPRSRTFPRPSNHSRLASILTYFISTSTVDAKIRPHDQIVGFGRDLLYRPLATLWTELRVWMGFSFAVVLWTLGAFPSGSGSRSIKASAKSLVIAESKASETRETPSVFPVDQDRLRITLGYASSHIGFFVDQSERLVFVLDGERIDEQWIEKGEKTEEGQLVDVNLEGCWTAMGAPTGSEWVVEVGQERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIK2</accession>
    <name>A0A2X0MIK2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C011g06547 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C011g06547</name>
        <name evidence="1" type="ORF">BQ5605_C011G06547</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIK2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY12582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="54" mass="6053" checksum="053286B95A419E83" modified="2018-09-12" version="1">MGSMVRLRPGLMNVGRIVGVPMNSTLSKKSERHEIALEPHWRPKLTGASYMDCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIR3</accession>
    <name>A0A2X0MIR3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C018g08762 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C018g08762</name>
        <name evidence="2" type="ORF">BQ5605_C018G08762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY26719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIR3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY26719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="409" mass="45930" checksum="2B5080A5C4EB68E9" modified="2018-09-12" version="1">MVRFCNWKPLGWLNEASRLSAPSLASPAASRRLCHHRHYPTFSLRQLRRNVSRRSGYRASRLPLRQPTADTQITQIQLSWSTDEPLECDTLPRPLDAWRDKFKDRGAITAARKQDYTERMRSIVISSQKWVEIYLGVDIKSQHLIVKALEVLPSLLIEEQYTPSRILGCSASLHTLLDFVGKQPNCLPFSRPMTRPMLKQRNTSCSTSFILSQAQIIRLPSLLRHESRQLALDLNSLIQHRRAHQCAHLRAVLLKGRHGATTSTAQDPDPTSKAKLSEHGEVHSSVLRGLVQSRGAARLEAVSGVARSIRWTGQATFSRFSTANETENIGYIEDRRKEIRMQLRARQYTAFAKNPPFGSIDGNVTSATPLKIGSLVCFGLKRSITPVSCDASNIGEEQLSIGLGSYISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJU0</accession>
    <name>A0A2X0MJU0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C036g11483 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C036g11483</name>
        <name evidence="4" type="ORF">BQ5605_C036G11483</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000063">
        <property type="protein sequence ID" value="SGY95264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MJU0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15466">
        <property type="entry name" value="CLU-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2280.10">
        <property type="entry name" value="Hypothetical protein (hspc210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033646">
        <property type="entry name" value="CLU-central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025697">
        <property type="entry name" value="CLU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027523">
        <property type="entry name" value="CLU_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023231">
        <property type="entry name" value="GSKIP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601:SF6">
        <property type="entry name" value="CLUSTERED MITOCHONDRIA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT EIF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13236">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12807">
        <property type="entry name" value="eIF3_p135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103107">
        <property type="entry name" value="Hypothetical protein c14orf129, hspc210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51823">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clu" evidence="3">
        <location>
            <begin position="461"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="250"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="840"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1137"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1571"/>
            <end position="1598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="863"/>
            <end position="881"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY95264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1598" mass="174353" checksum="456DF5F18D14853F" modified="2018-09-12" version="1">MTDSAAPDAAAAAPIDSELQQPAAQPQQEQGDEEPGQVDAEARAQLFEITLVIPSQSFIALPRSQERQPNKDNHLEIPLPSQLQDAVLDLRNVITESPEGFWLGHFGLRPIVSDRIPGSQTEWGPWVDLPEPSTEQQQQQPAQQQGGDVSEFTGWRLSNEGVLGEYADIAAVFGSGEGYENRRRGLKVVPTPYTALAMNTHLLRLRNILFSDLTQLSSNASYDPTSLAIGAGQTIYRDVRGQAPDDVLAAAAAASVHAEDSPEEDGKGKSKKGKSTKKQPASTEVNGTAAPDATTPAAPSNSTSHVFTNFKLEALSAAAFIEHLQPAASSTLSSPCVRALGISPWSPPPHARRLRGDHVYITLTTLEGESYTITGAAAGFWVSKITSANFDPSPRTVLPKGVRSGAYYSLVELLADLSPLFAKNLVPLIQSQQHLLGTTDIYATLAITHQAPAASWIVATPQHAMDPFRTQLAYLLTTSTTAEQLPPARDWTDEFAHAKEIPKTSVAERLMRERLTARTQADFVSSATRCAMSIARGDIPALNPNEAPEAHTYVHNNMLFTKAEDANRMYSHMGDHEAARYAAAKDVAGVRWLERADIDGLNSMATVLVDFAGQRWIVQSLLPGLFKSKEEEEPKLVDGEVENLMTFPEGDDAACKQAKAALEADKPFPSEVTPNKDDYSSFGQFRIVYGSANPEVPDEKVRASAYFDGLARQVADKLRFARHTVRDVAGQETQLYTSTDMHGIACPDGRSYFIDCFRLHCVDVEFIENDVNGPVFGPSREGGDDSAAVKVNGAHESRPYPHRLALLRMELLEAYHAIKLRSWMEERIVEIRAKNKDKLANGTANAPAEGSIESELQEAAQDPEPKAEPKADTDAAEERTAVPESSANTVIDAEDFWLRFNPDAFVERKPTASGEPSTVIYDADEPSSKAVRDASLYLREQVIPAFIVDIVSVGMIVTDGFFLTRLLHRKGINLRYLGMLADRIDKDAKTVDFSGKRHSQEEINIALKTLKQSVLLEMVIRASKHLLNRSLRAAHEYDYAPIFSHFLNCLLGAALEPAPSAEIFDLPLGANLERSWTRLTPASLRSELVAEIESRFRYRIPTSFLETELVPNKVLREVCLRVGVQLVARHYSFEAPTSTSTKEGKVPTTTNASEASKGGKKKKNAAAKSASPTEAPATTVFRSDDVLNVFPLVRSTPLKSQLADETFAVGQQSLTETHIDLGTEQLMEALQLCETVCGSVHSEVSAKYHNLGILNHSLAQTVSRRIHYHDLAESQLKEGKPDDEARTRLESLLISDIDGARLEHDTLVNAAVRMIRQSIIICERTNGLDSTETIQQYSDLGLLEMALGNHSVAMRLTKHAMVLWALTYGSNHPTIYQLLTNAVQMVQQEEQGFLAGVPLLKELGKLAELLWTRDSINFATVESSLAQAYVGGGDFAQSLEHMKVAQSIYAKLLPADAKDLVEATQFVNVLTEQLSQVGTERQAREERLKKKFPRLMSEKEQRQMVAQARARQIVSGGASTATTNGASVSATPAAASRLAAEKPVEVAAPRAHGQKGMLSVDELVNFIQGSSLNGTSASSKASRKRKTSPPGAAASAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJV0</accession>
    <name>A0A2X0MJV0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C020g09142 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C020g09142</name>
        <name evidence="2" type="ORF">BQ5605_C020G09142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000082">
        <property type="protein sequence ID" value="SGZ17777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJV0"/>
    <dbReference type="STRING" id="796604.A0A2X0MJV0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044716">
        <property type="entry name" value="LEUNIG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44376:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL COREPRESSOR LEUNIG ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44376">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR OF FILAMENTOUS GROWTH FLO8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="775"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="457"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="565"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="750"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="780"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="803"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ17777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="926" mass="94033" checksum="B0D041FF229CD272" modified="2018-09-12" version="1">MASQAPPATQPPPGSQQPPRHSSIAPTPTLLTNSWEGDATLHSYCYDYLKKRGWNSTASAFAADAGINEAEWKGPPIEAPQGLLYEWWSVFWDVFIARSQKSGPRNPNADVFVDAMRHKRDPLVVNFSGPNPPPPIMLPRTMGHPTRPNEPSQPPGPSPMGQTRPNYTNPAQIHVLEQQQLQQQMQQGRVSVVGMGPGGPPTRPPGAPMPPGSGGPYMPQASTSSQPMGPPGSSQHNHLLGGTGGPAASPGGFIGGPPGSHSNLPPQMQASQGQGQYGLGSHTSSSSASPHLAHSPHPFGNSPRPGPGPTGISLPRLIAGRPDLTAAFNQALRMVGIEGKEVETLTADEHAAVAAQMRRMGVLPELRVPPTAGGGPGGPPNGMGIVGAAGGPGGPGGVVQRQMLGPGGQGPPQGAMMGQRVVSGGAMRPGPPGMHQLEQGGPVQQRLGQQFAGMSPQQQQQMQQMQQMQMRQQNEMMMQQQQQQQQHQHQHQQIQSQQFPHQQQQGALRNGQGGPQPQHMQHMANQGDTPASPAFSAASPHQFNQNAAFQNAGSIGSPQPPPTPSAGAPTPGPSAANAPTPGGGSGKATYAPPPQRGPPNPTRGGRVTTVAGKRGAGGSNVEEPSPRSRKRARGGASGGGNLSREDGNDVQPPGTPDLAKSTPSSPGMAPPNLNNPGATMGYRPAPSPSQSQLDGLQVDQDGRAAMVSGSGAFSGGNGSGDANISGADGSNQPNGAMYGQANGNGGGGNNSRPSSAASNQYHGGQGLVNTLVRRDSISNSGGGNGGGGRSPPNMQIAMPPTPSMHQMHQHLTTSGINPSGGEGNPGAMAVTPGGTARPFAGAVAAPSSMATYQASNTGGSGGNGTSATNDGNNAAAGGGAAGGGGMPTLSQLGGSGSTGDDLYADLQFDMAFDSFIDFDTLGDGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0ML48</accession>
    <name>A0A2X0ML48_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C013g07386 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C013g07386</name>
        <name evidence="1" type="ORF">BQ5605_C013G07386</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0ML48"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY15502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="81" mass="9090" checksum="854BCFAD4570149B" modified="2018-09-12" version="1">MRFLSDALVVATFVLKSRPHPRNQGKTAIEALLGRTAPNVYVSKERRTKLASRSSQGLFIGYSHLSCRGPNVEQSLLHRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0ML75</accession>
    <name>A0A2X0ML75_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C031g10992 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C031g10992</name>
        <name evidence="3" type="ORF">BQ5605_C031G10992</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000068">
        <property type="protein sequence ID" value="SGZ07104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0ML75"/>
    <dbReference type="STRING" id="796604.A0A2X0ML75"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16279">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42663:SF6">
        <property type="entry name" value="HYDROLASE C777.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42663">
        <property type="entry name" value="HYDROLASE C777.06C-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="92"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ07104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="434" mass="47820" checksum="16F787BD3DA19A03" modified="2018-09-12" version="1">MSLTTPTPPPLLEFHLLGTGTSSSVPSIHCLTSPTEGCHCCRSTLNAKEGTDEARNVRRNTSGLLRVPPRVGQELWKTCGKTFYAAALEHWPKHHLRQINALLITHAHADAFLGLDDLRGWTLHGSIQKSIPIYATQDTYDEIARCFPYLADRSKATGGGDVPAFEWHIITPLVPLHLFGIEILPLPVHHGKIFSDPPRPYLSLGFMFDREIVYISDVSYIPEETWQVLEGRSTIQNSDAPLGKKEKGLASESLSLPSQTPRPSLLILDTLRSTTFTSHFGIGESISTIRRLNPLRTYLTGFAHGTSHSTWLQTCLKISSGSTAPSPSEPSLLKPSEKTPQTLPCPPPIGPNPTSTHLLPPPSQSWLAISGTLQKGQENPLVHSEWALKIIDAFEPLKKGVKCWVRPAVDGLVLKVFGEEGVRERRVWDGLYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MM16</accession>
    <name>A0A2X0MM16_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C025g09959 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C025g09959</name>
        <name evidence="1" type="ORF">BQ5605_C025G09959</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000087">
        <property type="protein sequence ID" value="SGZ26796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MM16"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ26796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="73" mass="7726" checksum="0975F1FD81E64F5B" modified="2018-09-12" version="1">MCTIVNSSKSCQAAAPLFAASAPACSTLALAPPSPRRDLVIFDQLYYVSNVVIAKSDESLQHTYSINSTTSAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MN82</accession>
    <name>A0A2X0MN82_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g02237 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g02237</name>
        <name evidence="2" type="ORF">BQ5605_C003G02237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MN82"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY39567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="238" mass="27012" checksum="E7545CF75B3D6AC4" modified="2018-09-12" version="1">MLNSGGSSSLWTRAREAEQLPQLDCWDLTIPIGQVQLANLAFGRTCRGCGKGNARKVDWFLRARLCSSCFRSKLFPDRLVLEGPDEPDPAFAQYFMGTKRYTPRSRTGKKWKMIRTFFFEPALAATSEWLSTLFKPVLDEAESRVLEPEDVEDLFDRPTEQIQRRLDERQRWVDAIQRDGQRLTEWSLLRHSAFQTGATTLSTARAQAQAHQPPPRRVPTRSQNENRPNATGGGGGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNH1</accession>
    <name>A0A2X0MNH1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g02317 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C003g02317</name>
        <name evidence="1" type="ORF">BQ5605_C003G02317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY40063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MNH1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY40063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="132" mass="14896" checksum="DDFF84889D78971C" modified="2018-09-12" version="1">MAHRPGRGHRQSTWTRRRKQLHTKIYLGQIEFMLHTGNRFVRELASDEAPSPAKEWVLRLCLPPGRDRRTHNTPQPSYIEHGDGVLICVSDSNPQVLTLQVRGDRCPDGRPKQQGAVSACSVPPRCLSVTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPW8</accession>
    <name>A0A2X0MPW8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C047g12297 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C047g12297</name>
        <name evidence="8" type="ORF">BQ5605_C047G12297</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000113">
        <property type="protein sequence ID" value="SGZ31070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MPW8"/>
    <dbReference type="STRING" id="796604.A0A2X0MPW8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF35">
        <property type="entry name" value="RE23632P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="104"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGZ31070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="302" mass="34160" checksum="D11D0F0E997C2286" modified="2018-09-12" version="1">MPSALSNRVRSVIRRQLSFFSWALLVDWLVVVGLWWIGTYIEKQEPYKQDVVHYLGDHDISWPHTQHERVSVEKLNLLSVYLPLAIILLVSALRRSVHEMHHAALGLLASRALMTITVEFIKNRVGRLRPDFLDRCAYSVLSHDCTGPHHLVKDGRRSFPSGHTSASFQGLFFLCLFLAGKNGAFAFQAQFPRSTILQSRMLRLAITLSPLLLATWIAITRLEDHMHHPTDVLAGSTIGILTASLGYALYWNNPFDADKLHVMGCARKVYGAEEEDGELFLERDAVESDLEEEARRGAVEEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQ80</accession>
    <name>A0A2X0MQ80_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C025g10085 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">BQ5605_C025g10099 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C025g10085</name>
        <name evidence="3" type="synonym">BQ5605_C025g10099</name>
        <name evidence="2" type="ORF">BQ5605_C025G10085</name>
        <name evidence="3" type="ORF">BQ5605_C025G10099</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000087">
        <property type="protein sequence ID" value="SGZ27220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000087">
        <property type="protein sequence ID" value="SGZ27267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQ80"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="322"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ27220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ27267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1097" mass="124739" checksum="FECB7978D35936A2" modified="2018-09-12" version="1">MSRLDGVYTDAIRLMHPLSPATTRPHLSKDGQLISRARIDFVLVQRRHERRIVSTSTLYNISRSMSDHRPVTVTFRLRASGAEVEEELCLPRAAHFLTRINSSTFKHAEFKEFVTLFLEQAPSGDPVADLQRVVSQSWVQALELSRRLFRERNALEMMLVSRLQDNESRRVLSPFDIIDWTNTHDALTKLVNERARQSRIRAHVPEIASEERLSRPEHAKLAAGSRDVKFQSIRLADGELSTDIERALEHTHSHFQQHYLVEGKDPEQVVTMRDELLGPIRSARPCDDPLSDARFLRRFSNSEMYRACPLLWAPLLTRAYNELITRGSLTPQQSQANVRLLFKHNKPGAARCDLKSYRPITLRESDYKNFTKVYVARLNRILSDVLPAEQHGFVKGRRPADATLHLRLLIDENRGRGAEFPTAALLSLDQSSAYDMVEHDWVFAVFEALGAPESFQRVLRMLYNGETSPARYIVNGFLTETVRLLCGLGQGDPLSSSVWDVVFQPFLDSLSRRNIALTITLPELAPRPQTRCITNLASGLAIATNGRLNTDKTVVMPLGATLWDRADLSKLSFVAPDESLPRIGLQFAPDGNNRLGFHDLERRVDRVILSVRDRWVTHHTRAFYLNRYDISKVLHSLSADIPPSDVIKAASLPTFVKEGPRCSDYKQSVVFTTRARGGLSVVSIQDVVDSVSARIWDVLASGSTAIWGDLARSSIRRALPTFDFAADLWTWRNADAPRELHPRWRAVLSVAERYPAVVDPAKLSVSNFFSLSPLQPGLHDTRAFSEQDKCLAKLFTFERAIADIYARAQYPAAPTVPWTPEKHPQGDGLELSNLWQWKRDQVQAWIQVAGDRFIPPLPPPVPVLARRPPVIRVVGAPGVRPGSPLEHILPRATPVGMPDQKLPLPSAPLPADQWRMLSLDRPYTIARLRRVINHRRFDDTQRPGSLATSKERRLFWVWFHTGPATAREREVHFKLAYHFRPTRKRQFGWRMTLLTFWHDCPDSSQFWQAARSILCDVLGVVSILGLDYTALQIEHGLPRLRARLPASKLRPIRAFIALALDTLSTRRWDLHRYARAMSSLDKEMAGLKERLELRLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQG4</accession>
    <name>A0A2X0MQG4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C025g10013 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C025g10013</name>
        <name evidence="7" type="ORF">BQ5605_C025G10013</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000087">
        <property type="protein sequence ID" value="SGZ26969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQG4"/>
    <dbReference type="STRING" id="796604.A0A2X0MQG4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF13">
        <property type="entry name" value="THIAMINE TRANSPORTER THI9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGZ26969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="492" mass="52790" checksum="37EB0F974924F4E6" modified="2018-09-12" version="1">MAAFGGMYFVGGMKILYSTGIYSGGPPALWSSWIVTMFGACATAACLAEICSSIPLSGSIYLWAAAVSGPTSPNRARIFGFIGAWWTSSAWISFCASTSQAVANFIMSELVVFNRAFPGGLDNSNIKFRAVQWAIAEFVLFVCVLSNTMPPKRFKWIFRASLLVMVIDFLALFIALPIGAAKTYGFRGREFLTTSYNGTGASSGWNWTLSFLSTSYVLTGFDAAAHIGEEVKNPSLAAARGVFYSCLVSAIFGAPLLMLLLVCSPPLDVLFEAAAPQPLVVLFQDILGTGGQLVLSIISIIGLMVNVSVCLVAASRLISAIARDGILPGSAWIGRVDKNGNPTNAVYFVGGVGAVLLCTILPSTVAFTSLVSISGVPTIALYAAIPVLRLLFTRDQFKHARWSNGRLSTPLCIIAAIWNLFICSIMFSPYTFPVTAQTFNFAAPVFVGITICGIISWWIVPEERWLSKEFIQAAGHSRVLEDSSVYSSDKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQM1</accession>
    <name>A0A2X0MQM1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C025g10073 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C025g10073</name>
        <name evidence="2" type="ORF">BQ5605_C025G10073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000087">
        <property type="protein sequence ID" value="SGZ27178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQM1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ27178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="94" mass="10666" checksum="20275C130CF0A9A0" modified="2018-09-12" version="1">MPSKGLPPFGACPACEMPPAEPLQVAQMPPRKQGAQLRQKGSLTTKQRASQQSKEGLFEAWSHAQHQPKRRAPQATFDRPRRARKRSERVFEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQQ2</accession>
    <name>A0A2X0MQQ2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C025g10089 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">BQ5605_C025g10103 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C025g10103</name>
        <name evidence="2" type="synonym">BQ5605_C025g10089</name>
        <name evidence="2" type="ORF">BQ5605_C025G10089</name>
        <name evidence="3" type="ORF">BQ5605_C025G10103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000087">
        <property type="protein sequence ID" value="SGZ27230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000087">
        <property type="protein sequence ID" value="SGZ27280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQQ2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ27230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ27280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="164" mass="17504" checksum="AF21EB041B9B5976" modified="2018-09-12" version="1">MSPVASKRSKKNASPPRDTNNSPQVYFTRSQSSTPTTSAPRGFIVAANPFASLAGDVAEEAQEKPAQAPEDDEDAMSVVEAHLEQQQEVPPLEPSDLSDLQDRGAEGNQGEHTETSDAEEGESQSAETGAVPEIVSTTPEHTPELTRSRTASHHQLDMDGPPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQS3</accession>
    <name>A0A2X0MQS3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C024g09933 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">BQ5605_C067g12838 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C024g09933</name>
        <name evidence="4" type="synonym">BQ5605_C067g12838</name>
        <name evidence="3" type="ORF">BQ5605_C024G09933</name>
        <name evidence="4" type="ORF">BQ5605_C067G12838</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ26531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000135">
        <property type="protein sequence ID" value="SGZ35359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MQS3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1266"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="654"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="562"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ26531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ35359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2066" mass="230048" checksum="EA61593620F6B306" modified="2018-09-12" version="1">MSTGDPGSPPPAPPPPVSATSVQPPRDQIPISSKKTQATGPATAAPNYAAAASQATQSPEQQQQQQQRAKALGSLLQAMGAVPGNRMDRWVQAIYFAELYPVATATSLKFSALNANRSVENIFDYALEVTLSHQSASRASHADKTDLVACVTRLLSPISPICFEPGVPLPDHLAAYRPQILGVQHSSILRNGAAHHRVTVGFVTGEARDAALTTPPALTWRSAKASFAKSHRFHHNMVELRINVGVQGVPSMDAIIKSFQLLVQDLSGKGHSCQLVQVLRIISVDNASAFAHVAGDYSAFLHFDDDSLFKRPNTTLKEILPSRIGLPTRGIPVTALRHDYEKEAACGRCHFVGHVGTCGLDQESKRKEAHNGNGNGNGNTNANKNTITNDTNIVEAEAPIPVPVVNRIASQNRFAGLEVEEGQEEAVTGQSGQGPEESGEEDAGDKADDEDSEDSEMESEATAKTEVIKLKSEDESVLEDCGGSDGEVIDEDEVMADGRGETEGKVATEMEEREVATEMEEEEVATEVDDVDEAGGATKAENAEATDLGETNRLDNDDDSDATATAATASRESTPHEPTPPLSPETLAKSLREGEEWDRIRANWVEQARLERDQSIERRLDAETPLVRHNFATWDEDGEIRSINIRGTAAKFKKPVMKRSQTAADLSDPSDEPTDAKRVIIKGKSRVVVKDGTEGRRVTRSMSAAAAMPVGVTKVDRGKAKGVAEEKRWSDHEPEDDRFDLNYPLMIKHTIITWNVRRGMGVPEKRRDIYNYLSLFKASAILIQEHFIRPHLWQLIKDEYEGKLFINQHCLTLIPADSPLIDAELLRTHSALDGRLLVTSFRLRGDIKILEINNVYAPVDPKQRAKFFDKLLFHKTQKSHLRLLGGDLNDCPRPEVDRRNQSRRGHHWPILIGKLDSAYTDCIRYKHPITPSFTRPNPNRKRPNSFSRLDYFLLQRTHQKRLDQASTIYDYPKELSDHRPVLIVLALSDDPDATLPQLSLPTTSNQLHRINTTTFKTVEFQRMMEGWLEGASGEEPVGELEVILKACRDRGGEMARRLHRERTERMEYLVGRVQDMEAIPEWGEAETAEWTRTSEELKRAVEERARLLRIRAHVPEIASEERLSRPVYAKLAARNSDSKITALRLSNGELTHDIDVALDHTQAHFQRLYHIEPRDPDRVDRLRDEFLAPIRAARTCDDPRSDPLFLRRLSESQIDLLQRPITEDEVVAAIGTTHPGRSPGPSGVPYELYQTAPKAWAKVLTKAYNAMIERGSLSPKQGQGLVRLIFKRHKKNADRAELSSYRPITLRECDYKIFTKVYVARLNQILPDLLPPQQHGFVKDRRSADAALHLRLLIEEVGARRTEFPAAALLSLDQSSAYDLVEHDWIFAIFDALGAPATFLRVLRMLYSGDSTSARYIINGFLTAPVRLTCGLGQGDPASSSVWDIVFQPFLDALHRRNIALNLSIPALHPYPQSRAITSLAFADDVVVAVAGLGSLNLLDDLALDWRHATNGRLNTDKTVVLPIGRRWDPGQRPLVVKAAGESLEWIGFPFDPSGDTELAYANLIERLEATLEGVQHRWLTHHTRAFYVNRYAIPKILHFLAADIPPPEVVKKLDDMLVDFVRGGNGRTSYGRDIVFTAKLKGGLGVIRMQDVVDAVAARIWDVLLGGSGAIWQGLARAALQRAQSDLDLATDLWPHPSTPIPSDLHPRWRAALGVPKQQDAQVNPRTLTTANLLALPTLLGSLHTPIRGRQTIDAVHIPDYFRLQGYPKVADLYRRELYAGGGFHLWTPPADVLGDNSEYDRRGLPQRLAIAAWYRFTVDRHKNTPLAVAVAAGRLNVPPRIGTSAPLEAILPKPVARFAMEQRLPDMLLPQQASQYKLLNMARPYTIRRIRRVLNAKAFTNTLGLKGPPQPDDLRSFWKAVNSKALTAREREVWFKLILRFTPTRKLQHQQNHDTSPACLVCEAPVDDTDHYFFGCVDSRNVWIAARGVLCDALGCDTIEDAHEQEGAGRTIEMFTGMVLEMISSGRWSMQKHGTRMESVERRRVVLEERMKLRAGGARGGRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MSF6</accession>
    <name>A0A2X0MSF6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g03848 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g03848</name>
        <name evidence="2" type="ORF">BQ5605_C006G03848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY54164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MSF6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY54164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="215" mass="23191" checksum="DC86BEFBB44258ED" modified="2018-09-12" version="1">MQALNDAFDGLLPLTNMNMTIAELLAFDVAPADASLHIELSKDELTHYSTLSSTRGPTSSCSTRGRPMESSDPTRGEAGVGVSNTEEGCTLTTNEIQKNAYIEDGRIQEKLPERDKQYGALAQHYPHFGSLDGAVTAATPLEIGSLICFGPKCGMHSLSCDQTVYGEEALSIGIGTLFDNKPQQPRHARLVGSTLKCRRTGASPPQENMLFHTPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MSG6</accession>
    <name>A0A2X0MSG6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C002g01027 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C002g01027</name>
        <name evidence="4" type="ORF">BQ5605_C002G01027</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY29226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MSG6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040185">
        <property type="entry name" value="Far11/STRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021819">
        <property type="entry name" value="Far11/STRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012486">
        <property type="entry name" value="Far11/STRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239:SF4">
        <property type="entry name" value="AT25231P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239">
        <property type="entry name" value="PROTEIN REQUIRED FOR HYPHAL ANASTOMOSIS HAM-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11882">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07923">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01293">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01292">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Far11/STRP N-terminal" evidence="2">
        <location>
            <begin position="243"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="Far11/STRP C-terminal" evidence="3">
        <location>
            <begin position="713"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="604"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="786"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1010"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1062"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1225"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1411"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="530"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="620"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="643"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="687"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="796"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="817"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1062"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1246"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1310"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1418"/>
            <end position="1437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY29226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1553" mass="169315" checksum="87CE806722F6387E" modified="2018-09-12" version="1">MAPRSTRQPSFDRCSPESPPRNSGAHDPLFSTALPLPSGPILESSASLQYIAPPPAGPPPPPLGALPPPDPSSHIAMAVPSSSTPGSGSASPDSVPLPTPITNASLASPFASSSTPTDASNDSNNGNNGNNGNNGNNGNNGNNGNDGNDDLDSTRTTTDDSSLSSTEPSSTSTTNLNRRHAVTIEPQPGPINTITSVVTTGAANALPPGPNPGLNPIPPTPPVHAQEGPPNKNTPAALPKPKQALYTFPSPPPDSSDIVSELQEFYSYVEVPQVIDHKDSFLAWWDRPQQAFIDVPQTEQIELIHSLLDGLASPDPDARFTVARHLLYIAQGTFESSTFPDHHLELIQANCALLRNAKALDAIWDAVKKTGERWERVSHLPNTNPGSNDPSSSAGAGESQPLNIVEFEEAQHRQEQLDEINSELALLLAVLYFMMEVHRGDDDWAEELMQLDPPAPIYLFNLVAGLRERNAKGYPVKKLLLLLWKSILACIGGQSDIPRVRALVRSIEGLEPNPSRPRTPAPQTRPFPPSSSSSTCDIPSSPTDSVIADAKPHTKVAPTDFVAFNSEITSKYPSYIPPPLPIKLPIPIEMERIAAAAAPQPVRPTFSYHLNPNHDPTIPSNQSTSSQQQTFTGPGQGQGQSQGGLQNSASATPAPTPPTSPSPTPPKPKKQQYQTDQSKPFVLPFAPSNSGIPSTSTISSSSTTTKFNSRFVPRSIEEAGQLYATHLRLSTELWQSWKVREEFLYEETGIAQAERLVVKKEKEKDQGDGLGKKGLGGLSKRLRDLSGLGMGREGNELDESAIDGDDEGEEDQAFGGSREKEQKNEPRAPDPLEMLRKMEREVIRLAKEEGDPERRNELEDKSKDLKRLMRVEMLYRAVLPQMQSAVIVLLKLLLATVTANNSNQNQGVGNAESGNDEPIELSLEDMDIMRHREITSKAVSAILILALKWFKTSHVMKFHYLSQLLVDSNCLLLILKMFGLQEVSTSVKTKNDREDQNFFKFCHDMVNPPDLNDPMTYRGRRPRSSSRDSLSDSDSSTRAQKGTGRRTKYVTTSLLINDDRSTTTPVTTIQQKPEGAQVKNNNKSAEDDQVEYITDYSWRNFFSVINFVHILQKLTKRKTHRVLLLVQYKSSAILKRILKVSHPTLQLYALKVIKSQVPYCGRKWRQSNMKVITAIYLHCRPDLRDEWLTGIDVDHDVEESLPHEQALRALVRFFNTKHYGSYAPQLHRRSSATSPSNDFAASRGAVEGGNNLGGYGPGTSGGGLPSPSIGGIGMNHDLNHPLLSSSSNDDVFPPSRPITSFGFDHPDELSNPTHNGQTLLSPTSPTLSRYPTDYPSNLDEYADYEVDDLLLYPRHIDEDGYLSTSEGGVLDPLEASRADWERLGQLLGQYDEDISDSESVGSLRGLLRFERGEGREGEGEEGSDDDGVSEFELEEERMDERQRKAIAVRNEWEHISPETITALEEERAAALPHSPRPSRRRSSTGPISPALRPVLIDRDDDSALESSGGSAVDEGGDAGVGGAGSAGPNSPGPAPAAPHQGPAVDEVELVFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MSP0</accession>
    <name>A0A2X0MSP0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein bL21m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C047g12303</name>
        <name evidence="4" type="ORF">BQ5605_C047G12303</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000113">
        <property type="protein sequence ID" value="SGZ31094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MSP0"/>
    <dbReference type="STRING" id="796604.A0A2X0MSP0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="bL21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="bL21-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL21M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="L21p-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00044129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ31094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="258" mass="28587" checksum="E0336C393DF5C855" modified="2018-09-12" version="1">MPFPIAPTRLLFSRSSKPVAASWRCSFSSTSRDQGLPPTLPKHERLSALSPKPLPSTSASPLELLASQPSHYITCLLMGRRYTLTSHDVLTVPKLKSVRAGQRISLTRILEVGSRDYTLRAGPSPSSIPPRPTSAVSAKLSSFQTSTPLLRPPMARTIIDASGVPRDWQRHPDSLPYFKEGEVKAEVLVLEHIKGKMFEVEKFKRRKGYRRTLRSKLEFTKLRVGDIILGSGESASTSGETTPKVLDTELEIEGEKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MT90</accession>
    <name>A0A2X0MT90_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C045g12193 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C045g12193</name>
        <name evidence="1" type="ORF">BQ5605_C045G12193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000115">
        <property type="protein sequence ID" value="SGZ31520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MT90"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ31520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="57" mass="6435" checksum="B55CB0D085D9014E" modified="2018-09-12" version="1">MQLLEYLECLPRENGKVGMCMQALLPNKMARRFPLPVPGDFSMKAHATARVPRMSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MUD5</accession>
    <name>A0A2X0MUD5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C007g04519 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C007g04519</name>
        <name evidence="6" type="ORF">BQ5605_C007G04519</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY61044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MUD5"/>
    <dbReference type="STRING" id="796604.A0A2X0MUD5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000020">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.950.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000006">
        <property type="entry name" value="60S ribosomal protein L8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023672">
        <property type="entry name" value="Ribosomal_uL2_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_uL2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007180">
        <property type="entry name" value="PRK09612.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="5">
        <location>
            <begin position="2"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="4">
        <location>
            <begin position="95"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY61044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="253" mass="27066" checksum="2844183F5934AC46" modified="2018-09-12" version="1">MGRVIRNQRKSGGIFRAHTHHRVAPAKLRALDYAERNGYVRGIVKEILHDPGRGAPLAQVVFRDPYRYKMRTETFIATEGLSTGAFVYCGKKATLSVGNVLPLAALPEGTIVCNVEEQPGDRGSLARTSGNYATVIGHDADAGRTRIRLPSGAKKSINALGRATIGIVAGGGRIDKPMLKAGRAYHAAKAKKNNWPKTRGVAMNPVDHPHGGGNHQHIGKASTINRHAVSGQKAGLIAARRTGLLRGSVKVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MWP6</accession>
    <name>A0A2X0MWP6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00074 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00074</name>
        <name evidence="2" type="ORF">BQ5605_C001G00074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY43876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MWP6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY43876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="128" mass="13624" checksum="9DAC2A20A5CCD8BF" modified="2018-09-12" version="1">MKDLNSSNCAYVLHVACVYLSWTTPPMVAQAHSAPACMHCPSVVPSKPPPSPHMTSQARVHPASAAVAFPPPITRIIDPPLPSLPSSPRTPTHPTHLGTCRKPCNPGECATVGGSGSRDYVMRHTRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MZM0</accession>
    <name>A0A2X0MZM0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C008g05265 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C008g05265</name>
        <name evidence="4" type="ORF">BQ5605_C008G05265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MZM0"/>
    <dbReference type="STRING" id="796604.A0A2X0MZM0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF1">
        <property type="entry name" value="CN HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="NITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="236"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY79974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="354" mass="38977" checksum="5D5599853EF0E9F1" modified="2018-09-12" version="1">MAPIKVAAIQASSCAYSLDESLEKLWTFTKEASDEGRAQLLVFPEAFLSAYPRHLAFAIGSRTYEQRDWYARYLESAVKIPPGAMGQRHGDQDRSETRDAPANDSDEFRASCPTIGIIERSLVGATLWCSKILVSPEGVVWSQGHAWNEDQQGSSLQVVDTPIGKIGGLICWETFMPLPRYALYQKGVEIWTAPTADARPTWAPAMQHIAQEGRCFCQAQAQAHLVVPLFPSHQPTNTISHPTTPRTIPPTPHPLEPPKRPKQKSGVAFLFYLIDFINSIISRGGSVIVDPLGTILAGPLWDKEGILYAEIDVSCIPGTKLDFDPVGHYAREDLFNFSVPTDHAPRGVETTGPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N0E2</accession>
    <name>A0A2X0N0E2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BQ5605_C009g05546 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C009g05546</name>
        <name evidence="11" type="ORF">BQ5605_C009G05546</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. DCP2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY82124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N0E2"/>
    <dbReference type="STRING" id="796604.A0A2X0N0E2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140933">
        <property type="term" value="F:5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03672">
        <property type="entry name" value="NUDIX_Dcp2p_Nudt20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000003">
        <property type="entry name" value="M7GpppN-mRNA hydrolase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1050">
        <property type="entry name" value="Dcp2, box A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007722">
        <property type="entry name" value="DCP2_BoxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036189">
        <property type="entry name" value="DCP2_BoxA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044099">
        <property type="entry name" value="Dcp2_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114:SF17">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05026">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01125">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140586">
        <property type="entry name" value="Dcp2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="10">
        <location>
            <begin position="143"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="363"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="442"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="522"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="628"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="704"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="975"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="365"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="470"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="526"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="553"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="575"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="722"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="978"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="991"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1014"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1036"/>
            <end position="1051"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY82124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1062" mass="115434" checksum="081259E6D24659C8" modified="2018-09-12" version="1">MSYHDGPTLASTIAASSSSPSSSSYFASLTLDHTLEDLCARFIVNLPTEELVSMDRICFQIEQAHWYYEDFVRPSALNPLPSYGLKAFSLLMFRSCALLHDASRLALPSINERPFLTPTSFPDGPQLIPSHQQIWTSFMAYKERVPVCGAILISQYWDKVIDELLFQTSRAWIDLTLRLPPPKVLLVKGWNKGASWSFPRGKINKGEPEGMCAVREVLEETGYDLSSAFPPEQLQTNYVEQEPAERVPYYVELVIKEQKIRLYLIPGIHEDTYFETRTRKEISKIDWFKLSDLPTWQKDKKGKKNASQIEGKQAKFYMVTPFMSCVLLPSPVFGCMVTQLSFLFTRHLKLWIERSKPKNVRKRAPVSAIPIAPAPTSRAAIDSEPEPELSTSPSGFGSTTEDDDLTDVEVYSASAPLAAKEFESTQEATDALNAFFFGGSPPKESAVQHQPPLRLPSAFPPFQSNAQSAEVREDSPGLSTRERFSSAGTTLPHVAYERQSSFVQPKPQTSIHQTDKLLALLASQTSPPPPPPAKPPLSLPNNKMNLLGILRGQGQSRSVSSPKPSPNLLPDASSPLRTNASPSMLFDNSQPPPEAKGFGVEHVATHAERGQAERQEKRNALLRALSSVASAPVGHHPPTTPSSTGVRALFNSASPSRRSTGVTPPVVSSSLANLSLQDDDLDQRGWPITATEKQLTAARIGLGRQGTLMPLEPEESGEERWSSSAGSQARNTKQAFDELDAARDDWIEQGRPVGGVHSPSSKQHAVLHESMPSIEHHSASLPLPLESRLSHHSGSSDGSRRAVSTLHTAISASKGVNLLSILNGKAPTPTASLSSATPQAYQHVEAMTQVLPPASQAYQTAPVSQPPTALMQQIHLPDLTRPNATPPFGGGALANQIPSQPSLPPVPGGYYAQPGYVVSPHMQHPPQPSPQASHSHFVPGGYYFTPQAPSVPNYQNPYPTAPGSFITLQQHPPYVQHQGYSNRSPQSMHLQQPPNGGYQYPQHPIGNPQASGVASTSFAAPAPSSQSMVPPPSGMYENSTPPTGLKTTAHSGQLLGLLNARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N5G0</accession>
    <name>A0A2X0N5G0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="23">BQ5605_C020g09051 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">BQ5605_C020g09051</name>
        <name evidence="23" type="ORF">BQ5605_C020G09051</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 25">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000082">
        <property type="protein sequence ID" value="SGZ16648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N5G0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0229">DNA integration</keyword>
    <keyword evidence="18" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="16" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="15" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="16" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="17" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="22">
        <location>
            <begin position="417"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="657"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="704"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="757"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="666"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="775"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="SGZ16648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="790" mass="85192" checksum="E7FE4A22D1F29C91" modified="2018-09-12" version="1">MSNPAISTRHATCATREAGRNGSTTSKPNARTDLEHANFQAIALLRRSVSLNIKKQIKDGFDHTPTNVLKMIKKAVAAGTVTDIFIKLQALLDAGPPPSGVDAFEKYQANTIELFNTLSGYNLTFDQVISIHLIHFGKDLYKEYYTQALRQDLDKLPDPIEALQTLQTQAESTPAHKPVAMVASLTATDRSSSTPSAPCRHCGGPHWNRKCPVKDKKSKASSAPSASLAAAPDISTLVDGPVRGYLTAAMSTLAKPSLILDSGATHHIVNDRACFTNFRKCKPAPLEGITGEAVNSIEGVGSAVVRSFDGSIGQLHHALFVPSAPVSLFSASRANAAGYDINLSRGKATVSVDGSICHTGEITNGLYHMHASLVDLISTEAVLGVNMEVALNADLKCDTCQAGKITHHPFPTVASNRSAQPLDRVHMDLLAFDGAVSLGGAKYALVIVDDYTRYLWAIPMSHKSDTFAAFKSWLAKVERSSSRKLLAVRSDNGGEFLSNEFSSFLEEQGITRQLSIPDTPQQNGVAERANRSITEGVRSMLHQSGLSHALWAEALATYVYVKNRSPHSANSGVTPHTRWHGSKPSAGHLRVFGCRAWKAATTEARSKLDPRGIPLVFVGYDLESKGYRLFDPATRQVFKSRSVTFFEDEFPARREGITAAHAPVAGDDDDDDDDDDEVVVLPDQHANQAPPDQAELPAALRFDAPGPAWQPPVGSRPRNPPARYGALASLRSTPSAFAFSLGKEVTELVADLEAAGIDTSTANRPLSEPEDPFSLPSSDPTTWNEAMRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N634</accession>
    <name>A0A2X0N634_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C008g05097 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C008g05097</name>
        <name evidence="4" type="ORF">BQ5605_C008G05097</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N634"/>
    <dbReference type="STRING" id="796604.A0A2X0N634"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036149">
        <property type="term" value="P:phosphatidylinositol acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF16">
        <property type="entry name" value="LYSOCARDIOLIPIN ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="3">
        <location>
            <begin position="160"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY79293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="440" mass="49924" checksum="018227C1071ED938" modified="2018-09-12" version="1">MVAPPHDVGHSKPLPECPEDLSVADRPSPAVGKRRGLGRESGSGRLHEIPIRSRSNPPLWKRLHALAFTLVFGLQLVSIHTLQLLLSPLHLLRLDKKTRLWHYSAAQFCKRLFSSALLVITSLFAPTTFVITADETVDLDQVVVLDKKGRFKKLEFDQQSLWIANHQQYCDWIFSWILFALAHLDGGIIIILKASLRWAPIVGPAMQLFEFVFIDKKHRLQDSDEIYHHVQRSTALGLPFQLLLYPEGTLVSALTRPKSEAYARTLGVPDLENLVLPRSAGLLYCMRTALSVLPTLTLYDLTIGYEGIPPKGYAQSYYTIFSWFGYRTPSPRVHLHLHRLAAAECPVGPGIEKGKSLRTIEQELTQKDRDAFDKWIRKRWEIKDGLMAQFYREGEFPKGRQGSREIEVRARQRDWIGIALVFVLFFTVSSTVGGAALRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N776</accession>
    <name>A0A2X0N776_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C009g05538 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C009g05538</name>
        <name evidence="2" type="ORF">BQ5605_C009G05538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY81989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N776"/>
    <dbReference type="STRING" id="796604.A0A2X0N776"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="607"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="790"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="653"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="800"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY81989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="859" mass="92781" checksum="9F63D0F28A697E28" modified="2018-09-12" version="1">MVAITLTPHRGNSARFYPHSGYLGLAPVVLEGTVKTLIEEDRKPIKASSIVVRIRCYETEHSSTRRKGIKKTHVLYEKECEVWTAAASRAPSSSSDQVGAWAPLGDFSSPFRLVIPSENSGVSTCTFKSYRVWWQIEGGEPNPAWLPIRPYVSAADSLVVAACAAVINHKPMAMLGDSRIISHQIPLVRYPSPMSSPLPPVTWDSTTTLGAPAGLEFTIRSPTASVLQSDQIAFSLFFHTNDTRLQVKKVQFSLDRHMTVDCTMRSSTGSDSDEMQPPPDASDAALADEPSRQPLRGISSVFRRGSSQGRRSSAVSISPLPSPVYSTQSMDASSYVAIASVADTVTPMLSPPPKGKNSVLTNLMAIDVDNPSFDEEHQVVAQTPGSASLYRYSVGETMRTNIAQIAFTISAKIFLRGRTGAIEVIELAPRVVRFAGCSASALDQALQHITDSSIQHAKMPSRPAKASFNAQQLATPPLESSATLGARRSQNFHLIVDTTRPTSTDKTSSRSNDGDQIAARQRSGQSEMLNRGPIKSAKANFFGPPTPDSPFFEALSTPTPAKKTPFMASVASRPQPRLQQSPLSNPLGQPRHGLFPLATRPAHMASLDPITTSTPTASIVCPTSPANRHQSRRSARSPAPYSATNRPRSAGQLSSRSTTTSLSSASSSRLSREQSAPPLATSSCQLLSPDALPSLSLYPRQGSPDLLRDEWMDQDIFSDELRAPSLSRSSSTMSDIEDKRAAPASMVDFNSFSLIPTQVNHLHAYTLDKETRKVIAPWTTDVSPLEKRAIVTPPQQQPQSGMTRSSSNSGRTTGPAIVAGDHGRRKSSSGFGIFGRTSEDGDDKESSGRWGFLRRSSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N7J2</accession>
    <name>A0A2X0N7J2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C023g09705 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C023g09705</name>
        <name evidence="1" type="ORF">BQ5605_C023G09705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ24111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N7J2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ24111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="52" mass="5633" checksum="114E49AA25A81C49" modified="2018-09-12" version="1">MTHAIASGGLLPTTRMKDSRRALCQVSSTLPPRNLDVDLIPQSDQGHDLFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N8G9</accession>
    <name>A0A2X0N8G9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C038g11690 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C038g11690</name>
        <name evidence="1" type="ORF">BQ5605_C038G11690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000061">
        <property type="protein sequence ID" value="SGY91684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N8G9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY91684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="124" mass="13863" checksum="9BA01FF3C96BEFF9" modified="2018-09-12" version="1">MSQVMINGAMLLGFRLKSSAWPPVVQLNRASTVDLELGFGELAGVPSILIDSDVSSATFFPSLRYKYHPCIGVKTSVWYVGGAQFEEREPIALLSAPQLFELLLEYVRFSRYTIEAWLWSDGIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N9H0</accession>
    <name>A0A2X0N9H0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C035g11460 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">BQ5605_C039g11754 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C035g11460</name>
        <name evidence="2" type="synonym">BQ5605_C039g11754</name>
        <name evidence="3" type="ORF">BQ5605_C035G11460</name>
        <name evidence="2" type="ORF">BQ5605_C039G11754</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000060">
        <property type="protein sequence ID" value="SGY89527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000064">
        <property type="protein sequence ID" value="SGY98364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N9H0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY89527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY98364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="169" mass="18090" checksum="C816D1205A573808" modified="2018-09-12" version="1">MPVRFRTLFVSLERQCLLPLHSRNFSTLLLPAMTTASTSTNDHAALSSTESPAATIGGAAGVHVAPLLPPMQLSGHSGAPDTTAGTTYEGVLFGISAETIKWAKDRKDPPMSCPSRHQQVKRVWSSTAACRARKGRTRAILTCSSHKGSGRPGDGLDHRRRRTVAFGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NI09</accession>
    <name>A0A2X0NI09_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BQ5605_C045g12230 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C045g12230</name>
        <name evidence="12" type="ORF">BQ5605_C045G12230</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SCO1/2 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000115">
        <property type="protein sequence ID" value="SGZ31683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NI09"/>
    <dbReference type="STRING" id="796604.A0A2X0NI09"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000013">
        <property type="entry name" value="Blast:Protein SCO1 homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017276">
        <property type="entry name" value="Synth_of_cyt-c-oxidase_Sco1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151:SF5">
        <property type="entry name" value="AT19154P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="ELECTRON TRANSPORT PROTIN SCO1/SENC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037736">
        <property type="entry name" value="SCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="42"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="42"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="9">
        <location>
            <begin position="174"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037736-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR603782-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGZ31683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="341" mass="37474" checksum="4CB0CF9249288864" modified="2018-09-12" version="1">MRPTTTVLTVVKRLFRPVASCSSHQVGLNVQRPLRRHASTLIATTTSSTRPRSRSAPVLSAASLRSSSAPSNTRGYASDSYEGPSDSTRTRAAVGPFTLRAGAIFAVTGLGLYFYFQKEKAKIQAHKEQEHATANIGRPNIGGPFVLTDQDGKCFSDQDMVGKWSLVYFGFTNCPDICPEELDKMGLVVKAICESNILNALGNPPFAPAEDPDLFCPTAKSHKIDILPIFITCDPARDNVQAVKAYVQDFIPSLVGLTGTYEDIKKCCKAYRVYFSTPPDAKPTDDYLVDHSIFFYLMDPNGKFVDAFGRSMGPVEVENKIGKYLSLWNQTDGKEGWSDMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NLA2</accession>
    <name>A0A2X0NLA2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C011g06424 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C011g06424</name>
        <name evidence="1" type="ORF">BQ5605_C011G06424</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NLA2"/>
    <dbReference type="STRING" id="796604.A0A2X0NLA2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY12199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="77" mass="8351" checksum="504D9CEE69D86923" modified="2018-09-12" version="1">MSVDPFADPYEPPAWDSSYPIPTSGNFTEKALVKIAEAWAEADGGLLTDADILTLKTELERMALDPAALNNKRLTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NPT4</accession>
    <name>A0A2X0NPT4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C012g06876 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C012g06876</name>
        <name evidence="3" type="ORF">BQ5605_C012G06876</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0NPT4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058155">
        <property type="entry name" value="Skg3/CAF120-like_PH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25381">
        <property type="entry name" value="PH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="429"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="838"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="928"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1075"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1251"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1297"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1438"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1560"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1707"/>
            <end position="1742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="858"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="884"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="979"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1005"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1168"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1306"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1326"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1387"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1604"/>
            <end position="1616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY16455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1742" mass="186088" checksum="2AA7732D9251BD7E" modified="2018-09-12" version="1">MPSLFSSNHTNDDATWIRRKSIQRRSNSSSTSFGSSGTWRHPSALTSNGGGGAIITARATSPRSSPSLFDYDLNGAYSSTPPVLPLVSTLSFRHPSPQQSVHSNHSANLESSSSRPPLLPRGGVIGSTGSYSHSPSTMSYPNAGGGGAAAADQMLYAQEQRTGASYSHQANPPSTQQYQPQPQSGRPSLEYYDQQQIQQQQQQRFQQQHTRHGSAPPPQEGPSYAALSHHYDDASLNSSQRTYTAPQHHQQGPNTGGMARSGSDLIAGPPYGSQQQHGGGPSLSSSSLSMRDPSQSRELQQSTPPQSFGPGSNRSTPRNHSPAPSSSATNGPQQQHSGVGRDFVPPAVGASNSSMGPGTAAASAAKISSPSMNSLSGSDRVNNRLGQLVSNNSVSGRSMRDAPPPAPQTIAGEPLHDLGRALALLRSSKFYAEGFLMKRVDIGPDGKPHSGQADAVWAKWFVQLSGTIMSTWNAAEMEQAAQQNRTVPPQYLNLADVFVYPLPASPSAPPTPTTFQFAINSAGLNRVLFCAPHEESMKMWINAIRLAAWERSRANEIYTGTLLGMREPKPAGWIGFEAGLTPPGSPANTTGGKFEGYLKARLPGETEWRKTWAVLIKSKKQEPGASSASVTKKKDRRSSLLGAFGKKPVDLTDIDDLPGDGTFATMAFYGSKPTKKEAPLCIVQHVFYASAIYPESEKLIDRSGLFKIEGTFLNPHHSYKLGWGVGGRAERQGYALLMVEEGAAAAMLQWIVGISDVFKLYGRPRAFSFEPRDPSSLYFALPIGPNRDRQFLDRELVDALEVNELRPRAIRAVFHNILFDRMRGVHSSMLPPPQAVLPASAPQLEPVSRKPPPIQIREEDEDEPETEAEAEQRVNEEYGLGGTRDTTQLSTIGESESPPARSIFAPAVARPSSPIYHSAGDTAQEPVVNYANFTSSQPAKRGETPSPPPVITTPSHLTPRQALPNIATGSEPKAAVASTYATQQQTGAALNFSRPTAAPSQQSADTERGSGCRDAHEPLAPPPVPVATNGHEHESIYNVPALGAVAREGKTNKDSAPMLASSVAVNPVMAVAPAPVMTPPLASTSPPVPAKSPERAFKSLSSPQPDKAPFDDVSAKPSALHPIPQVPAAERSLEAEPVTPGGASSDIHSDLLAALEFVDRSESPPPLSSLVPTPSTVYDYGSPEIEQRYHVGPPRRASHSMFDAGSPVDLRQGVAQFTTDPNEVDEYQTEEISMPRLNDQRVETVSGVASYSSSTKGIDASPAQASMPFPSSFAPNKRAEERAAAAVLAQQALEAQQIAKSRPGRASMVPSASASSVNRKPRAWVDSDEEDEDEEEDDDEDESEGEGEGRDNRQSTLPSSIDPLVMTNRDTQSSGMNRLGLQDRNSRGPNMSSSPSRGDFQVIHPDSPQNHVQALKPLVNPHGLLHAGIIDKEERSAKALEAAARDTGGPLVSIPSKPPPPQTGLVGAITSLEREKERTGGVGRALTEQQKERKLAEQRQRQLDDLQRQQLAQQQYQMQAQYQQMQMMQAYGGMPPYGGGPPPWMMGGYPGYPPMMPPASQMGPAAPSSQVGSPMMMPHLAGGGRPSSPPMQQNGATSPPLDMQYQQQQQHHLAAQQAAQAAAAAAYQAALAQFSQPPTSPPLASEVGANGSPALHASTLMTSFPPAGVYGPPMGAYPNPYAGGYGGPPMMGQHPWMQGYPQQHLMSHGAERGDEGTPTANANANAMAQDLDRTMSPMQLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NSL3</accession>
    <name>A0A2X0NSL3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C017g08508 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C017g08508</name>
        <name evidence="1" type="ORF">BQ5605_C017G08508</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY20175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NSL3"/>
    <dbReference type="STRING" id="796604.A0A2X0NSL3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY20175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="457" mass="49176" checksum="E31F16CF5404955A" modified="2018-09-12" version="1">MRVPTQWLPTFAVASERNSRTCDVKWCPAVGANAASTCTSSGTCSFACKSGYKKSNDKCVKECVPAQCRRIPNSVSWCTTSGECDYTCKLGLPLQKAHTTCLKISDTIGEARCVMPCEVSKCRKVTHAVSWCTTSGDCDYTCNIGYQKKNAECQRIASICDPKQCLTVAHASSIGTSSKCDFACNTGNNKQRGCCVVTRKCPTHPHGVSSCTTAGACVIACNTGYIKQGSTCVATPPTCVVSKCPMQPHGASSCSSSGSCAITCNTGCTKQDSVCVLTLCQMLEVAFIRAMAAPHRSGDHFPGLVALSSARCLKEFGDSGFIHMDLSAEISILRTDCIKALAVVSHDCIRAQCSTSLIADEIDGRRLTGRKLRALQHAHATMFQLSTIAQRFHTLVHAFAPPFPSPDDLDLFAKEWNAATRLKSSDRNIQNRRRLKSRANADNTHTVQVDTAETSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NSN4</accession>
    <name>A0A2X0NSN4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C011g06339 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C011g06339</name>
        <name evidence="1" type="ORF">BQ5605_C011G06339</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY11961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NSN4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY11961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="74" mass="8594" checksum="9BC1128CBA99CC47" modified="2018-09-12" version="1">MPRYFWAGDVYDKKLTFRDLSIWYCQLVQQAFGECCLSPGALQTQRAQEDVGMPSNPKTWFNRPKLLSQDDCPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NTX1</accession>
    <name>A0A2X0NTX1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alanine--glyoxylate transaminase</fullName>
            <ecNumber evidence="3">2.6.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C013g07137</name>
        <name evidence="10" type="ORF">BQ5605_C013G07137</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.44" evidence="3"/>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY14866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NTX1"/>
    <dbReference type="STRING" id="796604.A0A2X0NTX1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008453">
        <property type="term" value="F:alanine-glyoxylate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004760">
        <property type="term" value="F:L-serine-pyruvate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019265">
        <property type="term" value="P:glycine biosynthetic process, by transamination of glyoxylate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000049">
        <property type="entry name" value="Alanine-glyoxylate aminotransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000027">
        <property type="entry name" value="Serine--pyruvate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152:SF24">
        <property type="entry name" value="ALANINE--GLYOXYLATE AMINOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152">
        <property type="entry name" value="AMINOTRANSFERASE CLASS V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="9">
        <location>
            <begin position="27"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY14866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="401" mass="42832" checksum="5EAF7ADBBBA49A78" modified="2018-09-12" version="1">MPSFKQSEHKLLLIPGPVECHDDVLLANAHPSMSHVSPAFAPSFAYCIKALRKVLYASTAQPFIIAGSGTLGWDLVAANLIEAGQNALVLNSGYFGDSFAECLETYGAKVTQVKAPVGGRPSLEDVEAALKKDKYAVMTFTHVRSTKAASEIRCGAAPPIATGVLSDAKALGELVKRVSPETLVILDGVCAVASEEIHQDDWNIDVVVGASQKGLSTPPGVSITTVSIKALKVLENRKTPVASYFANYKRWLPIMQSYENLTPAYFATPPVNLIYALEASLKQITEGSPSLEERFQIHREASKKFKKAAEELGFKQVATEPEAAANGMTAVYVPEGIAPPALVGALGSRGIVIAGGLHKDIKTKYVRFGHMGVSVHPSRNDVDVMIKGLQDAVAEVKHQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NZR2</accession>
    <name>A0A2X0NZR2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">BQ5605_C016g08281 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">BQ5605_C016g08281</name>
        <name evidence="18" type="ORF">BQ5605_C016G08281</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY21846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NZR2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="17">
        <location>
            <begin position="242"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="518"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="534"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="SGY21846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1154" mass="127099" checksum="489856B5A34A25DD" modified="2018-09-12" version="1">MLLMLRHYLDGRCSTCGGKGSQLPAQLQSCGPRCAKGVGWTSTGEICHEPWWAMPWEASSIHPPTHLEQGTCTRMTTCSQKRGCIPQLCDARPIQLIAILTGDAPDRLTVGGKLNARQGWTCRRRRKARSAAFQSERAGALRGTRSLSGLAGAGQGMWNTSRFRAPSAIHTLVTTKSHGIPLLTLHRRYGHASVQTLKKLAASGQVEGLDWTYSDLECVDFTCNACLASKAHRLPFPPSSFHASEPLALVHSDVLSFPEEPFSHKWYLVTFVDDFSRKTWVYPIGHKSKVLPTFKDWLMEIENETGRRVKTLRSDNGGEYVSTAFNGFCVARGIRRKLTIPYTPEQNGRAERLNRSIVEGTLALLIDSGLPRTCWDEAAMCYIHTKNLLPHAALKGGVPNCRWSGAPPLPPPTVGALRAFGCRAWATVPAHRWDKLDPKGIPLVFVGYDRHVKAWRLLDPSSMRVSLSRNVTFLETEFPFVAVPARVTPPSVPGFYPRPPPADAPAILLPPVLVEPTQPPLLDDDATSSIHLPQRPPEPAPPEPTPLAKVKPTWEYGDVAKVGPNPAKYGEIDARNIITGPRTRRQLVPTLITREDLVGGPDGPTPAFQGMLRAFASTKAGFAEHNLSVVRDPANWGNVIRLGQQDTWGGPAHDKFDSLLNKYEVFKVIDSCELPAGEILLRSGWVFQTKRNQHGDIIDHKARLVAHGCAQHPGIDFEQNYAPVVKFTSIWALIALAAANGYHVHQANVNKAYLHGKLDKPLYMRVSQGINMPGKILRLSKSIYGLCQAGTIWNAEIDSTLRSLGYVPTQSDICIYRHEHDGHSHYIALYVDDLLLVGPSTAEIDRVLDTLELAYGIKRLGPAKYILGIQFKCGHNGSITLSQERYLRDILARFQFADAKPASVPMQPGVVLNFENSSATPEDCTCYLQAIGSLMYAVVGTRPDLAFVVSCLARFLQQPGPEHWTAIKHVLRYIKGTLDLGLTYRKTNQPLHGYSDANWGACLTTSQSTMGYAFILSGAAIAWCSKREHRVAKSTTDTEYLSLLYASGDAIHLSKLLSELGALVPGPVVLYGDNQGSLALAQHPTNHQGSRHVRISEHYVHKRVAEKEIKVHYIATGDMFADIFTKALGPKPTGGCQSVYCCFIPLLLPITISY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P1E2</accession>
    <name>A0A2X0P1E2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C002g01308 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C002g01308</name>
        <name evidence="7" type="ORF">BQ5605_C002G01308</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY32037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P1E2"/>
    <dbReference type="STRING" id="796604.A0A2X0P1E2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013907">
        <property type="entry name" value="Sds3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08598">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="386"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="515"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="822"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="330"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="355"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="394"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="517"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="533"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="831"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="844"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="890"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="912"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="971"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1009"/>
            <end position="1034"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY32037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1053" mass="112020" checksum="1D025D2E9D83898F" modified="2018-09-12" version="1">MSDLTDQSSLSSDSDTDRASHAGPSGTSRTSRGRGRGKAARGRGARGARGAGARGGSAPTKRAGRGASLPQFPPREYSSPSSQGSRSSGFVASPSPELGAPPNGQSAHDAAPSDNEEGLVNLTSGPEVDDRQSDSQTPEEDQEEEEEDIDLEENDDADGSQSSSLSETSSLSSTGSPGPQPAVLLNGSSTINAFPIHRGLKRGRSSPLTDLSADESDKEHDRAESDEDEAPPTATSKRSRKRVVESESGSEDDATDVISSRRRQADDDDDGSEFDDDDDDDAAAEARAFDLGEASPALTDSNAPTRDGTPNDASRDTTPAPRASAFTAKSRGRGRPRGAKKSFPTSGAGRGRASPKNTNTSTMALQSFLTPMRATRATVTLPPGYIEGIGSSRWPKTSQGGSHGKTTSVEPSERHASEESQMTEMTVDVEEVSATPVDDSPAPVASSSGSKREEETSAEPTSTTVKGAALTAKPAEFEDDTQWPTPNIALATPTEGDELVGEMAVVARSENELVLKEEEDVSTEPEVEVRASPKPKPKAAGKKGRKGKQKAALDSEVIPDRPTLSKRRRLSEGEIERNAQRNTARMARLAQLAAEEQNIIDGTHPMVEAAYTRLREEKRRRIAGLSRTQSWREIAYERERDASIQKVWVAWADAKDQLRMSMFTENHQSLRQLVYEEKQLPFLRDHPLLMDECQVPPAPHFRAPILEGNQAFTPRKVIHAGHYLEAPPTNKALDHSAGQLSNEEINADLAVLMNPDEVFGPPRPQASPAVLDVSPIMTAPRPVGVPVYPYAPAYYYVHASQYGSVPAGHPAPPHTYYAMPPAPATVPTPPSTHAASALGPAQHSHQHPHQHQHQHHHHHHHAHAPGPAPATSSYDHHHSHPRPLSPPVSNTKTKQATAGSLPQSRASLNGTSSSPKSQAPPSAAAAPPALFRFPGPRSASGNPSASLPAPALQHSRDRDPGINTYPYPSMSLGSYSKTASGTHGQGVAQPQVTSYSPHPSGPYGWGALAQNSARASPTGPTASNASKSESSQHGGTYYGVQGNGQQSHYAYWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P1F9</accession>
    <name>A0A2X0P1F9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01338 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01338</name>
        <name evidence="2" type="ORF">BQ5605_C002G01338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY32241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P1F9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY32241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="122" mass="13591" checksum="AF5FB36B054D7D8F" modified="2018-09-12" version="1">MSCWCHIAPVTARRSHRLLKNGRAHGAEHNNLRVMLCEKECRPPIHRDIVAARNMPTVGLQVAAFQQHPFRYPKAGKDEDKQDEKGQQGSKATAKAKGSKPGGKGRDKEREEEAREGRVGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P1K5</accession>
    <name>A0A2X0P1K5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C002g01408 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C002g01408</name>
        <name evidence="8" type="ORF">BQ5605_C002G01408</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY32760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P1K5"/>
    <dbReference type="STRING" id="796604.A0A2X0P1K5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF52">
        <property type="entry name" value="ADIPONECTIN RECEPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY32760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="196" mass="22250" checksum="B94A2967F426D0B6" modified="2018-09-12" version="1">MKSFGNTKFACFYSAGFSASFHALGCHSKEVAHRWNNFDYVGIVVLISGTFVPAVRYGFFFRFHFEGDPHLRNLYITLIYSAALFTAYTVLAPHAKTPEFRRFRAWVFIALGTSAVFPVGHAVLRYGVSHKSHHFHATLYAERCPERFLPGRFDLFGSSHQIFHVLIILAAASHWAAISEGFRYWHGERGGVCPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P248</accession>
    <name>A0A2X0P248_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01648 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01648</name>
        <name evidence="2" type="ORF">BQ5605_C002G01648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY34530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P248"/>
    <dbReference type="STRING" id="796604.A0A2X0P248"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02989">
        <property type="entry name" value="Phd_like_TxnDC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21148">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY34530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="258" mass="28725" checksum="C5B0137379FB19CF" modified="2018-09-12" version="1">MAPPQASPSEEGVAEPSSSTSVHVKPYDAASDAAPTARQLAEMEEHEHEHEDEDDADLEELEKELDENFDLGGFRERRMEELKSQMQEIQKMRQSDFGKYNEYTKEKDVISATAKASRSLVHFYHRDFRRCKIMDSHLEKLAKKHFDTLFIKIDVANAHFLVTKMDVKVLPCVIGFVKAVSKLKIVGFEELPGGDNFTTSALEFGLIQADVIKDPKLTATASRVIGAARSSESSNSASRGIRSSSRIGASNDESDLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P569</accession>
    <name>A0A2X0P569_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytoplasmic tRNA 2-thiolation protein 1</fullName>
            <ecNumber evidence="6">2.7.7.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cytoplasmic tRNA adenylyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C001g00066</name>
        <name evidence="6" type="synonym">CTU1</name>
        <name evidence="6" type="synonym">NCS6</name>
        <name evidence="11" type="ORF">BQ5605_C001G00066</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="6"/>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY43824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P569"/>
    <dbReference type="STRING" id="796604.A0A2X0P569"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002144">
        <property type="term" value="C:cytosolic tRNA wobble base thiouridylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="CTU1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03053">
        <property type="entry name" value="CTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056369">
        <property type="entry name" value="CTU1-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032442">
        <property type="entry name" value="CTU1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000541">
        <property type="entry name" value="Ncs6/Tuc1/Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807">
        <property type="entry name" value="ATPASES OF THE PP SUPERFAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807:SF12">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16503">
        <property type="entry name" value="zn-ribbon_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal" evidence="9">
        <location>
            <begin position="69"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Cytoplasmic tRNA 2-thiolation protein 1 C-terminal" evidence="10">
        <location>
            <begin position="351"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="72"/>
            <end position="74"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR004976-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY43824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="386" mass="42537" checksum="176D8574390A02DA" modified="2018-09-12" version="1">MAPCALCPPGDALPRRAILRRPKTLQPVCKECFFVVFETEIHHTILGYGQAERNDKGKGKALFKRGERVAIGASGGKDSTVLAHIMKVLNDRYDYGLDLCLLSIDEGISGYRDASLDTVKRNAVQYDLPLKILSYKELYNGWTMDKVVAEIGKKGNCTYCGVFRRQALDRGAHLLTVDHVVTGHNADDVAETVLMNVLRGDIARVGRCTAITTGGDPFSSAEARDDDPNDDDGEGGKSLSSLLPSTIKRSKPFKYTYEKEIVLYAYFKKLDYHSTECIYSPTAYRGYARALVKDLEAVRPSSIVDLIYSGEMMAQSMSLKGRRVGGDWSGKEGELMGYKKLKGCVGRQVQQNCSKCNSLSSQPLCQACLLLESLNQGVAKVELSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P8I9</accession>
    <name>A0A2X0P8I9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g04172 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g04172</name>
        <name evidence="2" type="ORF">BQ5605_C006G04172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY56791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P8I9"/>
    <dbReference type="STRING" id="796604.A0A2X0P8I9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY56791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="370" mass="41860" checksum="8F2D1891BEA73471" modified="2018-09-12" version="1">MITTNRSWYCDPYKRPPYSFVERTAWPQIALKPLKPHVSIRDDLGSQAAVCTHCKAWHLECERICSQGKVQLPPLPQPNLEYRQLLEGSDSEAKAFRENARSYNNALSFTSLAAHWDQTQVGTLGPPVFRVLCSNMAHRPGRGHRHSTWTRRRRQSHARSTLTKLESILRTGNRFVREFASAKACAGWDTAKEWVLRLCLPPGRDRRTHNLPTSSTEMAMLICGSDTNTEDRGPQDLILQVHSDRCPDGRPKYQVISSLHPSAMPPVLTTLPRGGRWLPPQHSSLRGSTKPGRQSPETESRSTMVRTKTAMMRMKTARKGTKRMVMANDKGPVKGSRWRVSRSQFFAHYLPNATSTSQSRIAPDVPSWSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P964</accession>
    <name>A0A2X0P964_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C007g04423 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C007g04423</name>
        <name evidence="2" type="ORF">BQ5605_C007G04423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY60383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P964"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY60383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="138" mass="14996" checksum="5B13E5473E48C432" modified="2018-09-12" version="1">MVGGVPLGIAIIPTAVVVVAITVRLTIAQFSLGCRPSFVRCSSLCLMRWRVVARSVLLILLLLLLLLLLLLLLLLLLLLSLLIGFVLGGRTTLWGARARSSAFLWSMRRARVGTAFGIAVGGVITILLHVEERRRGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-03-27" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P9J4</accession>
    <name>A0A2X0P9J4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C007g04583 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C007g04583</name>
        <name evidence="2" type="ORF">BQ5605_C007G04583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY61662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P9J4"/>
    <dbReference type="STRING" id="796604.A0A2X0P9J4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="1">
        <location>
            <begin position="4"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY61662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="142" mass="15746" checksum="1391D9779EB85F13" modified="2018-09-12" version="1">MGLITHIVSFTYAPTVSSSEKHLIASSFLALKERCALPKDFYANTQAEAESDEARVEGETLDGGRYIVECSGGCNNSPEGFSRGFEHTFILTFCNKQERDYYLDRDPAHQAFKEMLGGKLADDGKGKLIGVWVFDFEAGVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PCG1</accession>
    <name>A0A2X0PCG1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C005g03287 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C005g03287</name>
        <name evidence="1" type="ORF">BQ5605_C005G03287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY73375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PCG1"/>
    <dbReference type="STRING" id="796604.A0A2X0PCG1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY73375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="479" mass="53629" checksum="D9345D4C96AAC9A0" modified="2018-09-12" version="1">MRPPTGLATSAWEVWGRLASAPRRGGANVPSRSTKAHHIFEHHLHTTSANGRAPIPSRPSWSSQLARGLKSFTRSIYQGTFHSIKSRYNHPHGPYVTSRIDHVATKSGHFHGFANLNHASRRPLKNGLRLRPSLVKSNFVGSKGLGSARQFSSSQPLFANVIHNVPLFLRAAGDRSLDGLDERKWIKTRRTLQKAELNMNTQTNDRLQAAGFMSKKVEMDKYFTALPCEAQVVEEKDATDALVDRSVDLDFDPIILILSVDPTFAFPVSSSTNETNHSPSIVQTFTSIEQAYALHAQRIKALHDRLSHAGVFDDVQHVKTEAVAWMDPITGKEHKEVHVTFDARQWTRKDVRAAIGEWNREGEWWRIIGGEEEESVRSSEQDEPLLMPLPSMFLEDRDDDESMYSYSREEANSVYSTSAASVDAWHEGSSDAEVLFDFQVDDDGTSAAWEEESSGVSDYEDGVRIFLDELDGFGDSFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PDE1</accession>
    <name>A0A2X0PDE1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C029g10704 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C029g10704</name>
        <name evidence="2" type="ORF">BQ5605_C029G10704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ15825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PDE1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ15825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="76" mass="8132" checksum="9B0838F6741132C3" modified="2018-09-12" version="1">MPTAAHLITASPSAFYHCRRIGIMRPNPVMKAGSSSKKRRLSKAHSKKGGYFEDGFGTGTGPGRLWDGRGMVAILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PE33</accession>
    <name>A0A2X0PE33_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C008g05209 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C008g05209</name>
        <name evidence="7" type="ORF">BQ5605_C008G05209</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TALE/M-ATYP homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PE33"/>
    <dbReference type="STRING" id="796604.A0A2X0PE33"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KN homeodomain" evidence="6">
        <location>
            <begin position="131"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="238"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="329"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="412"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="266"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="297"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="363"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY79724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="499" mass="55166" checksum="D22C8B91B629EFAE" modified="2018-09-12" version="1">MSVGLCDELDSIYRRFGSSYDENGAQETFSQLQSLLPRLAREISSGTLPPDAVSACVVDKVRQINIVSHQLSCLESESAEIEAAAKLEVSELLHGLIGKVGTTPLNQDEDFSEDSTSQEEDRSILRYRAFFLEHISWPYPSPSEGEQLLAAVPAHNRAQLSNWFVNSRRRSEWSALARNFGGGTKEGMEELIRRVESGHGSEEESESVDKVRKYFEDDGSLTIRPDLKEMVEKIEREMKRQCPSRKRKLSKRTEVWVDTPKRKRSSSGSRLASEGSSPSERSSPSERSSSSEGSRSTLASSPTFHSSSTLNPFEDLKMEFYQPQPLPRGLQAHHSCVDSPAASEYPNAGVPASRRCVSDSRSHTSPNRSTPPYRSVSSSFALGMESTLAGSLMMPIDPDFLATCPTAGSAWNGGESPKTSDYRFASTSSSTLGADHSDERSLNTTTTSNTWYETLQDDRWTDLYPWLGRTGSDSLSGLDMFGQDEEVNWLMGTELVGLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-05-29" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PEZ6</accession>
    <name>A0A2X0PEZ6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase epsilon subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA polymerase II subunit 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C023g09654</name>
        <name evidence="9" type="ORF">BQ5605_C023G09654</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase epsilon subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ23885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PEZ6"/>
    <dbReference type="STRING" id="796604.A0A2X0PEZ6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016266">
        <property type="entry name" value="POLE2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="8">
        <location>
            <begin position="306"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGZ23885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="585" mass="66561" checksum="136C7B1547B51BC0" modified="2018-09-12" version="1">MFTNQRQPAQPSSTTAADLARKVFLIKYNLQLAVGAIEWLQAFLDECEIDDEPTILDVYERLVAGMQGGGNGLDGPSKVTPSLLEATREKLSVQADQPVHEHGHHLESSHYLKIVDAFEMPAWRWGEERKGFEKSENLPSLTPGPKAKAQYLRDRFNIIKQTILRNDHFSPPAIAGIQRAEYNQLTSIKNLLGRQGGHFLIFGLLTRMEDGAFYLEDLDDKVELDLSEATPETGLFTEGSFVLLDGDYTLQSTFKVSEMGHPPCERREEAMKLYGHHDFLGLGAISKEEEADFVKSERSPQHETSFIVLSDLHLDNIKIMNAFKTVLAAYEDMDDADKPSLFILCGNFRSRPFLFDGEATRDYQDLFTNLANVLASYPTLIAHAQFLLVPGPTDPWSSNLLPRPALPESLVKSLIAKVPNITFGSNPCRVRYFSQEIVVFREDLMGRMMRNAVRLGGPRNDGDMANSRKALVQTIIDQAHLTPLPLNVRPVLWDYDHAMRLYPMPTTLILADKFDPYKLVYEGCLAFNPGSFMRQRFTWSTYHPHMPKPTDRMEERYVLKRLEVLRERSMWLMFRLDVHSELPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PFN2</accession>
    <name>A0A2X0PFN2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C009g05589 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C009g05589</name>
        <name evidence="3" type="ORF">BQ5605_C009G05589</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY82716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0PFN2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1264"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="652"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="560"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY82716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2082" mass="231929" checksum="57A467A891183EDB" modified="2018-09-12" version="1">MSTGDPGSPPPAPPPPVSATSVQPPRDQIPISSKKTQATGPATAAPNYAAAASQATQSPEQQQQQQQRAKALGSLLQAMGAVPGNRMDRWVQAIYFAELYPVATATSLKFSALNANRSVENIFYYALEVTLSHQSASRASHADKTDLVACVTRLLSPISPICFEPGVPLPDHLAAYRPQILGVQHSSILRNGAAHHRVTVGFVTGEARDAALTTPPALTWRSAKARFAKSHRFHHNMVELRINVGVQGVPSMDAIIKSFQLLVQDLSGKGHSCQLVQVLRIISVDNASAFAHVAGDYSAFLHFDDDSLFKRPNTTLKEILPSRIGLPTRGIPVTALRHDYEKEAACGRCHFVGHVGTCGLDQESKRKEAHNGNGNGNTNANKNTITNDTNIVEAEAPIPVPVVNRIASQNRFAGLEVEEGQEEAVTGQSGQGPEESGEEDAGDKADDEDSEDSEMESEATAKTEVIKLKSEDESVLEDCGGSDGEVIDEDEVMADGRGETEGKVATEMEEREVATEMEEEEVATEVDDVDEAGGATKAENAEATDLGETNRLDNDDDSDATATAATASRESTPHEPTPPLSPETLAKSLREGEEWDRIRANWVEQARLERDQSIERRLDAETPLVRHNFATWDEDGEIRSINIRGTASKFKKPVMKRSQTAADLSDPSDEPTDAKRVIIKGKSRVVVKDGTEGRRVTRSMSAAAAMPVGVTKVDRGKAKGVAEEKRWSDHEPEDDRFDLNYPLMIKHTIITWNVRRGMGVPEKRRDIYNYLSLFKASAILIQEHFIRPHLWQLIKDEYEGKLFINQHCLTLIPADSPLIDAELLRTHSALDGRLLVTSFRLRGDIKILEINNVYAPVDAKQRAKFFDKLLFHKTQKSHLRLLGGDLNDCPRPEVDRRNQSRRGHHWLILIGKLDSAYTDCIRYKHPITPSFTRPNPNRKRPNSFSRLDYFLLQRTHQKRLDQASTIYDYPKELSDHRPVLIVLALSDDPDATLPQLSLPTTSNQLHRINTTTFKTVEFQRMMEGWLEGASGEEPVGELEVILKACRDRGGEMARRLHRERTERMEYLVGRVQDLEAIPEWGEAETAEWTRTSEELKRAVEERARLLRIRAHVPEIASEERLSRPVHAKLAARNSDSKITALRLSNGELTHDIDVALDHTQAHFQRLYHIEPRDPDRVDRLRDEFLAPIRAARTCDDPRSDPLFLRRLSESQIDLLQRPITEDEVVAAIGTTHPGRSPGPSGVPYELYQTAPKAWAKVLTKAYNAMIERGSLSPKQGQGLVRLIFKRHKKNADRAELSSYRPITLRECDYKIFTKVYVARLNQILPDLLPPQQHGFVKDRRSADAALHLRLLIEEVGARRTEFPAAALLSLDQSSAYDLVEHDWIFAIFDALGAPATFLRVLRMLYSGDSTSARYIINGFLTAPVRLTCGLGQGDPASSSVWDIVFQPFLDALHRRNIALNLSIPALHPYPQSRAITSLAFADDVVVAVAGLGSLNLLDDLALDWRHATNGRLNTDKTVVLPIGRRWDPGQRPLVVKAAGESLEWIGLPFDPSGDTELAYANLIERLEATLEGVQHRWLTHHTRAFYVNRYAIPKILHFLAADIPPPEVVKKLDDMLVDFVRGGNGRTSYGRDIVFTAKLKGGLGVIRMQDVVDAVAARIWDVLLGGSGAIWQGLARAALQRAQSDLDLATDLWPHPSTPIPSDLHPRWRAALGVPKQQDAQVNPRTLTTANLLALPTLLGSLHTPIRGRQTIDAVHIPDYLRLQGYPKVADLYRRELYAGGGFHLWTPPADVLGDNSEYDRRGLPQRLAIAAWYRFTVDRHKNTPLAVAVAAGRLNVPPRIGTSAPLEAILPKPVARFAMEQRLPDPVLPQQASQYKLLNMARPYTIRRIRRVLNAKAFTNTLGLKGPPQPDDLRSFWMAVNSKALTAREREVWFKLILRFTPTRKLQHQQNHDTSPACLVCEAPVDDTDHYFLGCVDSRNVWIAARGVLCDALGCDTIEDAQYTTLQRLFGLPKLKAKLSEQEGAGRTIEMFTGMVLEMISSGRWRMQKHGTRMESVERRRVVLEERMKLRAGGARGGRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PHW7</accession>
    <name>A0A2X0PHW7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C049g12435 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C049g12435</name>
        <name evidence="1" type="ORF">BQ5605_C049G12435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000111">
        <property type="protein sequence ID" value="SGZ30699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PHW7"/>
    <dbReference type="STRING" id="796604.A0A2X0PHW7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37852:SF1">
        <property type="entry name" value="HIG1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37852">
        <property type="entry name" value="YALI0B21208P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ30699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="190" mass="20763" checksum="2EDF7AE52683CECC" modified="2018-09-12" version="1">MAPSTTTAPAVPATRTDLVLIPLAGSTFGFVSGVLTSSQLASKQFLAENAHRLPTTVQGWYFYQKTKNYRVLYSGVIGGLRTGARLGLWTASFVGFEYLIQTRLLQPVLSSPNLIASESIREQARAIKTRWLSATIAGVSIAWVAGRIYRLSRYAAPRRFLLGASLGLVSGATYDLRDWLKTRLPPPTNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PJ77</accession>
    <name>A0A2X0PJ77_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C100g13130 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C100g13130</name>
        <name evidence="2" type="ORF">BQ5605_C100G13130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000075">
        <property type="protein sequence ID" value="SGZ11055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PJ77"/>
    <dbReference type="STRING" id="796604.A0A2X0PJ77"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ11055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="113" mass="12158" checksum="1319BC2D3FAE19AC" modified="2018-09-12" version="1">MGFVFYLAGSAVSWSSKRQTRVADSTTDAEYLALSHAGKEVIYLTQLLSELHAAAAVAHDPVHTSGTRHIRLRTRHPRLKSTSRLRGGGCEESTLRSAQDLGARIEPGASAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PJP5</accession>
    <name>A0A2X0PJP5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C020g09175 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C020g09175</name>
        <name evidence="9" type="ORF">BQ5605_C020G09175</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000082">
        <property type="protein sequence ID" value="SGZ18279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PJP5"/>
    <dbReference type="STRING" id="796604.A0A2X0PJP5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="75"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGZ18279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="524" mass="57241" checksum="11C81741507F1F0E" modified="2018-09-12" version="1">MEDDTKPTMQHVDDRNPRFAPEATTTDGQLAPTVTYDTEKGTANSSYADSAAGVELRAERHKRERRLVCKQDFVILPLAVFLYLSAYLDRGNMGSARLQGLQKEVLDNSDTKYSIALSCFFITYIVFSIPGTLLAKAINPSTSISIGALIWSIAATCQAAAKTPGGLYTARLFVGLGEAMFGQAMAFHLTLWYTKKELAKRVGLFISAGATAGAFSGLIAYGVANIHNTKLEQWRILFLIEGLPSLALAIVVFFCLPSRPSISKFLNEDERTLAHTRLNEQSSFEASSGIEWSGVRHAFFDWKTYAFAVMYSCMNLTLGSVGGFLPTIIKGLGYSNANAQLFSVPPYVVALVFMLLLSSFSDRKQTRGIPVASVFVVGIIGWALLLAIPAHKATPTQLHVRYFGCICIVTAGYSAIPLIISWVSANTGTESQRAISLGMLNAIGQCLSVLAAFSFPTIQGPQYRKGIIINLAFEALGFIMAIVLSFYLRAVNSRRDRSEGEPQMGVTLNTHEDYDHAEGFRYVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PKA0</accession>
    <name>A0A2X0PKA0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C022g09457 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C022g09457</name>
        <name evidence="1" type="ORF">BQ5605_C022G09457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PKA0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ22228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="65" mass="7149" checksum="590F3252D0B610FF" modified="2018-09-12" version="1">MRLPTASTRSKVTLRPNRVAAELDAVQMACERIDGPPPASDPFLNLLSNVATAQQPIPWLLTRHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PPS0</accession>
    <name>A0A2X0PPS0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C064g12777 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C064g12777</name>
        <name evidence="2" type="ORF">BQ5605_C064G12777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000132">
        <property type="protein sequence ID" value="SGZ35115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PPS0"/>
    <dbReference type="STRING" id="796604.A0A2X0PPS0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ35115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="418" mass="45522" checksum="F48BD0FC5C6ABD39" modified="2018-09-12" version="1">MSSTSTISASTSATRVFPRFQAAIARRASAAVYATPPPPITRSAKTINLNAGTRARFFRADQEERRLDSRGQVQADEEKSARCKVIDEAAALALTLPRRQLRARSSEPFYSPRAPPDAPSPSEPLTITLNDALPSSLDPTSVGLQSWGSSILLARMIALNPTSFGIARGENERTLELGAGTGLLSLVWKGMSERLDVVGEEVIATDYHEAVLENLRRWVTGMIGLLKNCLTSFSSILASGTLPPTPPPSALQVPSQLPPRSTLGLAPRVPLLAPTPNLLSNVPVVTAYKLDWSAHALWLKSCVQQFLIQPNQYTPKPRKRRVVQTPTPFSLDSVKDALVGVELDSVRTTVPTPTTSDAQSSFTSVPSPAFHLIPPPSHTHIPDDPYRVAIKRMTELHRVKGIGRADEESYRLYEIGWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LPE2</accession>
    <name>A0A2X0LPE2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C011g06536 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C011g06536</name>
        <name evidence="2" type="ORF">BQ5605_C011G06536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LPE2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY12536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="615" mass="68250" checksum="A72843CC6297419C" modified="2018-09-12" version="1">MARPSSNYRSSVVPREPLLSHRRRQPHSNNNAVNNPFSHDPDDDILVCSRSTRCKPTITAISFDRTRNVTYSAKTTMVAPTQIRQGCNQTRSSNEVRTALHSPSRVLCPTQPLVTPLCQTIAPADEFDGHNVWDGSLFGKAAHPSSQPVARHSTKDNYGQAQCIGTTFDDEELYVGSQSEEDGAGVASAGLSRELEDHQGACADDTDEGVRTKRGRRQRVSASHGSLNENEDGEDPDLSSLVDDPLGDDNLDDDNDLGDGEVRLHKRAKKGNGKEAFFAPGKDDLPDVSMITPASTASELSAHADLLGTCGDGRQWFNMSELRTETRRYLIFKTNWDTRDYSCLISRLGDGQADARLAKVGGMRHGRTCGSSEYCRSRSLLEQVVSLIKAQHTKLLYDLEAVAPFVREWLEHEEAGQAYLAGPSTRLENGKQVPRYPEMLAFKNIVRWSTVEAVYKKCLRDSYINNDVAKDPTRPFRKGLCKATMALMAFEARRQRPGFEKRKNGTGYETLEQPELPKRCPGVASQFLGATADVFTAIASDPFIGRRFYKYTTCWKLDPTSKKMVSYNSEPGLLPTPENPRISDSDPNANKGFKQAAWAAEQVDAMQDLDFDHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LTK1</accession>
    <name>A0A2X0LTK1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C010g05988 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C010g05988</name>
        <name evidence="8" type="ORF">BQ5605_C010G05988</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR6 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LTK1"/>
    <dbReference type="STRING" id="796604.A0A2X0LTK1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051973">
        <property type="entry name" value="tRNA_Anticodon_Mtase-Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14344">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14344:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="239"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="1002"/>
            <end position="1042"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY13836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1089" mass="119124" checksum="79886548C8C77B06" modified="2018-09-12" version="1">MSLVSRHITAPITALATLATVPHPTLLAGSHTDLLVNLLGPRASSSPVYRCCVLQRERIHHIVVREVSDESYTWNVLVAGGKEAAWVSIVVTPPSCEARDGEQSTRLNSQQTIQVNVRHHFKLDDWILSCAFLRDDHVLFVTAHNSLQVFSVTTSTQSASTSVTVPPPHRIRTYHAPLRPLLWSSDLSRSTYTSLTNVRIASGSILGDVLVWGLKDVVIDDDASQGQEITLDSAAIKRFVGHQGSIFTIAFSPSGRYLLTGSDDRTLRIWNAEAPEESRPSQVLWGHLGRIWRARWIDEHTLMSIAEDASVRVWSLDYVKRTYRCRQVHSDGHDGRSLWAVTSCTIKPAGQDLGATVVLSGGADGAVRCWPVARDEEGEKRKEKELEFESVKGVIKAFSGVVSEVLGCVGVFFTGNGLVYSTALPPSSPPQLIHTEASIASIRITSSSTSTNVWIFSNSSKCTIITLSHELMPTASVTFPLHPPTFLHLSSTSPSKFLVAEQVSNTIQIWSLGNSKTPQQLSTMPTSLLQGTSIGSARSRIASAAFMSEKLFVLGTRAGEFVLVRMRKGEEGQILFRNQLHSDAINGIKLIRLKGSDEWDVETVSRGGSRSLHRLVLGGGTKGWNILALSETMIVKGAVVGILEAGRYLTAVKNDVVIVDVNGFKLETFPATRSRSSGTLLNHAGQSSYYRIDRGKIFYQNSPRKSSRLPLPIVFRGHHGREIRSVAFYQPSNQQDMTLLATGAENSTLTLSLLTTDPKRNRSISPVFTDTSLPTSVKTVTFLPTPKGDLFLLASGSQELLRAWKICFEGRGKKEEVRVLAWGEAELEGGEDQCETRIMDHCWVAVGREEEVFAVIGGYSDGSVKVLYVAVKVHHFDTRTKRFAKICESREKGKCVLTTKVIEVDGQQLLLTGRSDGLLSVWDIARSIAGDASGRGSMLESPLYSFHAHQSGINGLDTSYDAESRTIRVATGGDDGAVHVHRFEVSAEGQISHRSEDRMSKENAHASTIQGICFLSPTLLASSAVDQRLSIWEISTDELRFQSGLCLGISDCSTMDVRRVKGPSAIATGEEAWEIVLAGIGIEVVEYTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LTR1</accession>
    <name>A0A2X0LTR1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C011g06592 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C011g06592</name>
        <name evidence="2" type="ORF">BQ5605_C011G06592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LTR1"/>
    <dbReference type="STRING" id="796604.A0A2X0LTR1"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390">
        <property type="entry name" value="UROPORPHYRINOGEN III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390:SF0">
        <property type="entry name" value="UROPORPHYRINOGEN-III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="HemD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrapyrrole biosynthesis uroporphyrinogen III synthase" evidence="1">
        <location>
            <begin position="35"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY12750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="319" mass="35742" checksum="DB39615F287FA698" modified="2018-09-12" version="1">MTPPLSTRAHLLFVRTPSQPLPQDPYHSFALSSHFTPHHLPILQTTYQNIPHLAHLLKGPKTYDGLIITSARSVQALAKAQDANPTTEPTQAEGLLGGGGFFYQTPIFVIGQATSEALRTQLIQPPPKENVLGNDGTTGSGEKLARFIIRYFKNDDNRGRKWKLLYLVGDKNRDTLPSMLEVEDGRFELDKLRVYQTKALEGSQLEKEVDELVKEVVGGDDERNEEGKILWIIFFSPSGAKAACQEFRRRRWIPNDDNDQDGDGGFQIRIAAIGPVTRAYLQNDERLKVDAEARTPDAKDLLRCITEVEDKESGHVQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LTT4</accession>
    <name>A0A2X0LTT4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein kinase C</fullName>
            <ecNumber evidence="2">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">BQ5605_C015g08003</name>
        <name evidence="23" type="ORF">BQ5605_C015G08003</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="2"/>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY18194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0LTT4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20822">
        <property type="entry name" value="C1_ScPKC1-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20823">
        <property type="entry name" value="C1_ScPKC1-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11620">
        <property type="entry name" value="HR1_PKC-like_2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05570">
        <property type="entry name" value="STKc_PKC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000101">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000103">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000014">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000064">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.160">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011072">
        <property type="entry name" value="HR1_rho-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036274">
        <property type="entry name" value="HR1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037312">
        <property type="entry name" value="PKC-like_HR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02185">
        <property type="entry name" value="HR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00742">
        <property type="entry name" value="Hr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46585">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51860">
        <property type="entry name" value="REM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="REM-1" evidence="22">
        <location>
            <begin position="196"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="18">
        <location>
            <begin position="279"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="20">
        <location>
            <begin position="510"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="20">
        <location>
            <begin position="578"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="1058"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="21">
        <location>
            <begin position="1318"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="88"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="655"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="728"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="672"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="765"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="784"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="805"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="836"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="871"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="892"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="942"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="970"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="985"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1014"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1033"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="1087"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="SGY18194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1382" mass="150852" checksum="7A2769E9533E73C2" modified="2018-09-12" version="1">MSLSSNTQDLSSKIASLHSRISKEHKILEGFQAMRSATSNQDVIRTCDAKIREAQKTIGWFEQSLHELQQRAGAGAVAGAAGAAAAGQGVGGVGGAHSPVQQQQHNSQRGASSMGRAAGYGNRPGANQPYTGGAPGGRDLPAPPPGAMPTYLQHQYGQGSIGGTSGRGDDARSEGVIMGEGTAVAKVHYSSLDLIKADTPLNTAKISRMLHQLEFKLHVERQYKEGIDKMAKLYLMDGDKKARADTENKRVESRQKMVLLSQALKRYKTLDVMGELGEDDDGISEDVKNNIRRPLSGALQITIRQARDLAHAPQPKKSKHSSETVIYVKVEDTPRARTHPSKTDRWNEDFEIHVDKANEVEVTIYDRIPGAEAPQPIGMLWLRLSDIVEELRRRKTGAEAGPGWVTAARVNAHPGSGGHLGAAGMDQPVVGEGSAANRALSYRGAGGEFGQAGGASEGIDAWFAVEPEGAIMLHLNFVKSNVRKRPYDAGGLGRQGAVRKRKEEVHEQNGHQFVQKQFYAVVLCALCGEFLLKGAGMQCEDCKYACHKNCYQKVVTKCISKSNADSEKDEEQINHRIPHRFEPITNISPNWCAHCGLVLPLGRKHARKCSEPNCGITAHAECVHLVPDFCGMSMVMANQLLSDIKKINDAKSGARRANQAVAPRPGRVAGTGTAQPSPYAQSTTTVGTAPVRRSESSSNAGYGAGRPPQQQGYRPSEELAGEMGRVNLQGGAAPTSTSRPPQSAGPAAADYSSYGQQPVYGAGEMQQQQQPTAYGQNRTSAQASSPVSSTRQSTSSTSTIASFGNDLQGSSLGSSDPIRGAQQSSQQQQSYPGGAYTTSQYTSTAPTSVSSQHSLGSYGQQQPVPQQPQPSSGYDAQRDQYTAPSRYEPVMQSPSQYTSSSSSQTSTRPSGVTTSSSSQAASQQSPSPQSRLPPFNSEPRLAASAQQQPPQQQGAPKTPQQQLQQQQAEQYKHLRELEEREHQKQLQQQRLVQQQQQAPPQQPQRAYEDAQMTPDVSSLPPVPPQSSAVRRGPQPPVTMPAPLPVAAPSRRHIGLDDFNFLAVLGKGNFGKVMLAEEKVSSQLYAIKVLKKEFIIENDEVESTKSEKRVFLAAARERHPFLLGLHSCFQTETRIYFVMEYISGGDLMLHIQREQFTPRRAKFYAAEVLLALEYFHTQGIVYRDLKLDNILLTLDGHIKVADYGLCKEDMWFGKTTSTFCGTPEFMAPEIILEQRYGRAVDWWAFGVLIYEMLLGQSPFRGDDEDEIFDAILEDEPLYPIHMPKDSVSILQKLLTRDPTRRLGAGESDAAEIKAHLFFKDTNWDDIFHKRVPSPFFPNITSATDTSNFDSEFTKEQPTLTPVHSTLSAQDQGEFAGFSWTAAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LUA0</accession>
    <name>A0A2X0LUA0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BRO domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C014g07568</name>
        <name evidence="8" type="ORF">BQ5605_C014G07568</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY19128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LUA0"/>
    <dbReference type="STRING" id="796604.A0A2X0LUA0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF30">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="7">
        <location>
            <begin position="5"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="766"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="819"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="839"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="858"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="890"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="907"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="968"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="998"/>
            <end position="1007"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY19128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1007" mass="109808" checksum="69469276ACD2376E" modified="2018-09-12" version="1">MASPPSRGVPQKVTSDVDFSSHLRSVIQRTYGEAPDHYTDEIHQLNRARQDALRGSAGSDVTARDLLYKYFGQLELLELRFPELRVPFPWNDAFTHVKIAQLSLAYEKASVIFNIGATLSSLAASSPRSSPEGLKRAFHSFRCAAGMFTYINDNFLHAPSTDLSREVVKVLVGLMSAQAIEVFIETMGPSAAVTKGAGLRAKLCMQASMAYANVIEEVKEWVTKNVFIREWSLLIQASQLTFFIFSGDLFQVKAKYFTSLAQYNRSLADSTSLKYGEALARLNIAEAAAKEALRLANAFAASFSTSSSASSLAPDSPVTLIELNKTHLGIVTEAKNKAQKDNDIVYNEVVPSEASLAPIDKGKDVAEPIAIHDVYATPEVQKIVGPDLFIKLVPLSVHESASMYSEEKAKVVRGEVERSDLADGELVAALEYMGLPASLERYRTGTSGQASLSDVGPQVRTWSEQLRRDEAQGRVDDSFRKLQQIKDNVTRQLDSVLQGLDQESRECEAMRVRFDHLWEQTPAAGLTKSYRQDLRSHKESLEQASHSDAQALGLWDGVKNDVALLCDPSGQALERAFIEAVGSASASSSQANLLDDPTGDEDEEEEIKKRVTSISDNLSKLNKVKKERHDVLKDLKERVQADDISHLLILNRKGSAALEPSLFATELDKFRAHQSRITATLQHQSSTLAEISADFKVISEGKKAREMQGRWGEAERHKRDLITRLGHAAQTYGEVRTALQKGLQFYGDLSELVEGLNNQVRSYLQERDGERSQMASSVSVKQRLEAPSSTTSPSLDRQFGAMDLGSRAGENPSWASSTPPAPPSHYSSPPPPAPPAIPAYPQHAYSSPTPAATSPYSNFPSSGAFSTTLAPQPPSQYSAYPSHYGHNPTSSPPPPPPPSQPYGASAPRPPSSSILPPPPQPVNYSGLPPPSQPVPYGQYSVPALPQHQQQQQYPSSAFGQSPAPPGSTPYQYGGPPPTSSYGGSQAPPQRPHYLPQGQPQPPSRPAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LUX5</accession>
    <name>A0A2X0LUX5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="28">BQ5605_C010g06209 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="28" type="primary">BQ5605_C010g06209</name>
        <name evidence="28" type="ORF">BQ5605_C010G06209</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0229">DNA integration</keyword>
    <keyword evidence="20" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="18" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="21" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="17" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="18" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="19" id="KW-0917">Virion maturation</keyword>
    <keyword evidence="24" id="KW-0862">Zinc</keyword>
    <keyword evidence="24" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="26">
        <location>
            <begin position="850"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="27">
        <location>
            <begin position="875"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="542"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="818"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1120"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="555"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="598"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="819"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="25">
        <location>
            <begin position="1124"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="1147"/>
            <end position="1174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="SGY14503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1711" mass="187513" checksum="41983A99AE16A044" modified="2018-09-12" version="1">MRQLLPPANPPVFPDDSKLTEDNYVDWDLTMSVTFAREVCAYLRKGTHDPSWPLALRSRWEDYAARALAGSLTVTTKATIGPIVQTGGSAHQCWLALAAHYAPSDAQAYSALIKDYFSMPPCPPTWADLEQAIAARALDDLPHVFDGWRTMFYAMNICDNRLPRVKQIFASMETVARTLRNESHPALVAKAVAPTTSTAPGKKGKWDRSGPAPSNCPACGQGKHWLDKCPDSRKRAKYVELRNAMKALQGASSSTTTALVAAAETSKDQDMSFFSSATFVNVGQPDILLLDSALVCHVVNNASFFDGPLSPTQQVLQGLGGTLRASGIGSIKLVSDMGTTFTLNDVIYAPESPANLISVRAFDRKGVRITFERGHVELRTPQGCFATASAIASRVYKLNASVRAGSKGALPSLVSTKSTRLPLLTLHRRYGHASVQTLKKLAASGQVEGLDWPYSDFECVDFSCNACLASKAHRLPFPSLSSHAAEPLALVHSDVLSFPEESLSHKQYLVAFIDDFSRKTWVYPIGHKSEVFQTFKDCTDTDTETDTIQTRTDSDTIQIQDTRTGTDTKIPLPQHERGPPTPTPAQPQEHQPKRRQDQGTNTAMSSGTRDGPPHTDNVARRVKLELPTLNAGFKSRDVTRWLAGCEDAIESAEWNYGGKIAAVHLIREAGCKMEGEGADWYIDCRDKVKALKLWPEFAQEVKARFINEKTGLEAKHAFYNAHQTGTLSDFVATLIAARGQAGSIGGTQVISDELFKDHLLHRCDELLYLRATASLSFDVAKFTMNQLVAYLQSLWEAITLERATTGVRRMGLRNDQVRQEQNNSAAHQTSGRPMAGLDRTPRDKAPHEGRCFHCDVHGHIAADCPSKPGTSLTPAPLRPTPGPRMVAAIREYQESGDSTAFVGISSDSEEDDARWLAFQTDKEDTYWLLEIENATGCRVKTLRSDNGGEYVSTAFNGYCVARGIRRELTIPYTPEQNGRAERANRSIVEGTLSLLSHSGLPRSCWDEAAMCYIHVKNLSPHAALGGDVPDRRWSGHTPGVRGLRAFGCRAWTTVPAHRRDKLDPKGIPLVFVGHNRHAKAYRLLDPSSMCMRLGRNVTFVETEFPFAIAPARVTQPSIPGYSPLLPPVQAPTPVEPPPQPPAPTPVEAPASPASTSSAVNDDASSTTSATMESAVNLPQPPPDPAPLAKVKPGWEYGDVAKVGPDPGKYGEIDARNIIDGPRTRRQPVPTMITREQTVEDPDGPSASFKSLLLAFSSTKAGFADHDLLVVRDPANWGDAEFNSLLNDYGVFQIVESCELPAGEILLRSGWVFRTKRNQHGDITDHKARLVAHGCAQRPGFDFKKTYAPVVKFMSIRALIALAAANGYHVHQADVNKAYLHGKLDKPLYMRVPQGINLPGKILKLSKSIYRLRQAGTIWNAEIDSTLRSLGYVPTRSDICIYRRKHNGHLHYIALYVNDLLLVGPSTAEIDRVLDALELAYGIKRLGPAKYILGIQVKHGQDGSITLSQERYLRDILARFQFTDAKPASIPMQPGVVLDFEDLAATPQDCTRYLQAIGLLMYAAVGTRPDLAFVVSYLARFSQQPGPEHWTAIKQVLRYIKGTLGLGLTYRKTSQPLHGYSDANWGACLTTSRSTMGYAFIYSGGAIAWCSKREHRVAKSTTDAEYLSLLYTSGDAIHLSELLAELGHPVPGPVVIYGDNQGSLALAQHPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LW10</accession>
    <name>A0A2X0LW10_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BQ5605_C019g08850 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C019g08850</name>
        <name evidence="11" type="ORF">BQ5605_C019G08850</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY22732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LW10"/>
    <dbReference type="STRING" id="796604.A0A2X0LW10"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015876686" evidence="9">
        <location>
            <begin position="21"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="10">
        <location>
            <begin position="45"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY22732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="425" mass="45846" checksum="99BCD013469E7A7A" modified="2018-09-12" version="1">MLSRLVLLWLGLSLVNVAAGANGLFCSALCRRRMSTCRSTDACAGKFVCRGQYWPAYGTQKPQAVDWSRTDIGYYFVSETDATGFNIPKGQSISALKTFVSTAHSKRKKAVFTIGGWTGSRYFSDRVATSGNRTKLVAAIREFLVKYDFDGVDLDWEYPGSQGIGCNKVRATDSANFLLFLKSLRATLGSKKLITAAIGASGLIGTDGNPLTDMKAFGAVFDIINLMTYDVGGPWSPTSGPNCPLRTCNSDTSVMQVVQAFKKAGIPASKMMLGIPAYGYSYQLKSSTLASKRIDGYVSRVYQAKTSTTPKGSKTDSNATSTDVCGVRSASYSGMWNYVDLISEGILSSNGSVGHMGFTRYVDSCSATPFLFNPRTKVMINYDDAYSAGQKTAYAMSQGLKGVYTFDSAGFNTAVLKSIRNKLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LW48</accession>
    <name>A0A2X0LW48_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C013g07349 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C013g07349</name>
        <name evidence="3" type="ORF">BQ5605_C013G07349</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LW48"/>
    <dbReference type="STRING" id="796604.A0A2X0LW48"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050585">
        <property type="entry name" value="Xaa-Pro_dipeptidyl-ppase/CocE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00976">
        <property type="entry name" value="CocE_NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056:SF10">
        <property type="entry name" value="COCE_NOND FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xaa-Pro dipeptidyl-peptidase C-terminal" evidence="2">
        <location>
            <begin position="334"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY15370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="603" mass="67576" checksum="52271C063D670079" modified="2018-09-12" version="1">MPTTFTIATKPIGKPTVGVNGFDGDHFGETTLLKAGSTRPGWDGETTAPLTSDIMLQHDVPLVMRDGAKLYCDVYKPADAKGPIPCLVMWSPYGKRYSSIDMLPVTTWKCGIQSKDLSGWEKFEGLDPARWCPRGYAIASVDTRGAGNSDGFVQIMGQNMGEDGYDVIETLAKMDWCNGNIGMAGNSFLAISQWHIAAQQPPSLKAIAPWEGCGDLFREQFARGGVFEISNMDLINKLIIKGNNGVEDFAEMCKSKSRSDDREPLHSPYWADKRPDMKKIKIPAYISGSDFSSIHTMGSIRGFWECQGPKWLRWAGRQEWHDLYVIKETNEELMEFFDHYLYGKGNNFVKDTPKIRWALLQGGDRDAIENIPIPDFPLPDTDYREFFLAEDGKLASVSPENASTVSYVSRGEGKSVVNFDLKFNEKTQLVGIPKAIVHMSADDHDDMNVYITLKKLDKDGNQLMHMTIPRERALAPSHAEIAEKDRTSLLLHPGSLGVLRASHRHIDASKSIHPNWPWHPHTFEEKVERGQIVKLEIGIWAMGWQYDAGESLRVEICGGHDMNHEIRHFTTKFPAESTLNKGVHKVHFGGEYASKVILPFVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LWD8</accession>
    <name>A0A2X0LWD8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C019g09000 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C019g09000</name>
        <name evidence="10" type="ORF">BQ5605_C019G09000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY23982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LWD8"/>
    <dbReference type="STRING" id="796604.A0A2X0LWD8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000031">
        <property type="entry name" value="RNA exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031736">
        <property type="entry name" value="REXO1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF115">
        <property type="entry name" value="FI18136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15870">
        <property type="entry name" value="EloA-BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="287"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="28"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="101"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY23982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="543" mass="59504" checksum="25A79634D8B8885D" modified="2018-09-12" version="1">MFPLTRRLFGPCPDLDTCQLRPCLFDHTPTANEHPRSPANTSTTTTTTTTTTTQLPLKSALKKRSHPTEQTEPELGSKQPKTILTTTTTTSTRPKTATSTGNSSQANAVASTSRSTLASKKQQQTAPPIPTTSTGASPPRITPSPGVPHIPVPIRQKLLHTLFEQFLLNYQSLPSADLAASLASKHAKEQEQALYTKSTKLTYRNAVISALARLKKRPSPASEAETGTLEDDLARQKKREEEYKGRLTTDRVQKFIHDVETLRKFDYVVQVPEGAGGDRPTEEGNVRRCDRCGKEFKVSAELTEAERTACSYHFGKMITEKHRGIKQRVWSCCPTAGAVTCSQGPHVFRDSAIDVLHSRVGFLETSSFESTTRSCPALDIVALDCEMVYTTSGMSLARLTVIDATGTIILDEHVRPQGAILDLNTRFSGVQEGDIENASLDVVGVRTALGILIDRETVVVGHGLENDLKALRCVHRKVVDTAILFPHPNGGTWRHSLRNLTKDILGKFIQDSDPALGHSSVDDSKAALELVRWKVKEQARLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-11-27" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LXQ8</accession>
    <name>A0A2X0LXQ8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative phospholipase</fullName>
            <ecNumber evidence="4">3.1.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C002g01073</name>
        <name evidence="7" type="ORF">BQ5605_C002G01073</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30909"/>
            <dbReference type="ChEBI" id="CHEBI:36707"/>
            <dbReference type="EC" id="3.1.1.47"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the serine esterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.47" evidence="4"/>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY29655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LXQ8"/>
    <dbReference type="STRING" id="796604.A0A2X0LXQ8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016715">
        <property type="entry name" value="PAF_acetylhydro_eukaryote"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272:SF11">
        <property type="entry name" value="PHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018169">
        <property type="entry name" value="PAF_acetylhydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="122"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR018169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR018169-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY29655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="509" mass="55789" checksum="1AF59DC3CBADDD33" modified="2018-09-12" version="1">MGLISSPLPTYTGTYHVGTLDVEVPVPEPGSFGTALLKATNEPALQLDTILCTLFYPVEPNNTNGKGRMPWMQRPIATTAQGYTRFLQQKPWLIRLAMAVFARNKYLPARIDAPLFPSTFPSTSSSAGAQRSTSESPSSSTSSKTVNPNPSSSSALPLLIFSHGLAGTRTTYSQYCGELASRGYVVAAIEHRDGSGASTIVNLGQGKKKVVKYFQPEDLIFPPPYPILSQIAYRREQLVMRLREIEELIDILSQINDGEGESVARKNRRAPSNGPSYGKQLSEWKGRLDFGKMSVAGHSFGATTTLEVLWAGSERFKFARGVALDPWLVPVEAQSKTGQAKLLTTTDSTSQGPSEEEQIKRLANEIKVPLLDINSEAFTMWQDQYELIRAIVENVQAPSWFMTLVGTIHPSISDVSLVFPRVVKVVGARLDGKEVMAKTVEVSEEFLGGLGKSGKWLSREVIPGDEAGLREGEGYFQNGGKPMEPVGDLRMHVVPKDDERKKKNNNPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LXY8</accession>
    <name>A0A2X0LXY8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C014g07593 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C014g07593</name>
        <name evidence="2" type="ORF">BQ5605_C014G07593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY19222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LXY8"/>
    <dbReference type="STRING" id="796604.A0A2X0LXY8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022234">
        <property type="entry name" value="DUF3759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450:SF1">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12585">
        <property type="entry name" value="DUF3759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY19222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="104" mass="11594" checksum="C8BC80B403A303E2" modified="2018-09-12" version="1">MGFFGNNEQEAHNAVYGEQQHESSWTHELIAGAAAFEAEKAYERHVSQNGRPANHQLAKELLAGFAGAEADKLFETKGLNFLDREKAKRQAREQAEQAVSSDNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZ32</accession>
    <name>A0A2X0LZ32_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C002g01543 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C002g01543</name>
        <name evidence="1" type="ORF">BQ5605_C002G01543</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY33768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LZ32"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY33768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="54" mass="6145" checksum="4987AADBAA33484E" modified="2018-09-12" version="1">MKSRNEISTEDVLLPTQTWHAEAHTRVAALAALFHSRGVRKGDRVAIRARNYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZZ2</accession>
    <name>A0A2X0LZZ2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C019g08876 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C019g08876</name>
        <name evidence="2" type="ORF">BQ5605_C019G08876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY22965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LZZ2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY22965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="63" mass="6959" checksum="DCB58E63C6C7D68D" modified="2018-09-12" version="1">MPNLDGSQASAAHTSKRETVRRCKSVDELAARSCVRRRGQRLVERSRRAAPASTCLHQPASLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M058</accession>
    <name>A0A2X0M058_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C016g08182 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C016g08182</name>
        <name evidence="10" type="ORF">BQ5605_C016G08182</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY20997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M058"/>
    <dbReference type="STRING" id="796604.A0A2X0M058"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF29">
        <property type="entry name" value="BENZOATE-PARA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="505"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY20997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="563" mass="62743" checksum="167D67ECA4D77F2B" modified="2018-09-12" version="1">MDSFQKYFDENTLQVLALAPSVLVALVYAIPFLTVHASLAKYPGPVLAKFSRLWLAIKSRFGVRSLSVHELHMKHGKFVRIGPNEVSIADPAALPIVYGHGTGSLKADFYSTKGVRRPDGMPCVRTSTDLTDRDYSIRLVVSRVWSSSAFVAVRTGLFNTRDRQEHTRKRKIVAHTFSQKSVQEFEPYIAETVRLLLKKWDELCDRAKNGASGGALKGYAVIETLDWYNALAFDTIGDLAFGSPFGMLERDAADIVAITREDGSVFHAPAVKILNERGEFSATQGALPPFIRPYTKYFDPWFARGLASVNNLSGIARHRVGKRLEEGSGDRKDILAHLLAARDGEGKKMPRDELTAEALTQLIAGSDTTSNSSCAIMYYIVKNPRVHKKLQAELDEAFGAGGMDGVLDYADVKALPYLQACINEALRRHSTSGMGLPRLMTQETEVCGEVFKAGTILSVPSYTIHHLNEVWGDPWEYRPERWLEQGGKDLETKCLNIFSFGPRSCVGRNVAMMELLIFVATFVYRYDFKLAEGENQQLEVAEGFLRKPLGCKMGIKRRTVEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M0D6</accession>
    <name>A0A2X0M0D6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C019g09026 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C019g09026</name>
        <name evidence="2" type="ORF">BQ5605_C019G09026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY24255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M0D6"/>
    <dbReference type="STRING" id="796604.A0A2X0M0D6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF36">
        <property type="entry name" value="PHO85 CYCLIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="538"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY24255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="624" mass="66064" checksum="AF9738D333267910" modified="2018-09-12" version="1">MDSIMDYTSPSNSSDSLSPLSAPDHISPRARRGSNSIDATAPEGKRLRSVGPTDSGYFSDASSASQQSSTTLDRWLLAAASGLSSFSRGSASECSDDSAIDLPEAEGAPAPRPRLQAAASMPTPPTRRSSSPPRPCSFDPDTEPPSPRPATLSSRFDARPRAARASTAPSGDGLAESVSKALSSLQVIPAQVEVHDSKIDAAFLYDATQRAQASDEAASLASSPSSLNKDRFVAGLVYTIADRDVWCGDVLGASVLAIESIWGASHSTTEATVTDGNVLPLHWFVKEVLRRSRTSCSTLQLALYYLHKSRRTIRETVARAEDSRPEYVRLEVRLLRGADAVADVAYPSPPLLPTDRHVVSDETRFAQLAESQQSPVLCGRRMFLAALIAASKYLQDRNYSNRAWARISGLPVLEVNANERAFLVMIEFSLHLDASDFCRWTQRLSALTSQGAALESAAASSASLTRSRPTLSVAGTSIAEPARQPCPVVVGDSSKQALDSLRSARLSKGAMALRQQLSPEDSDDGGSYATSSGDDEASSYCSTSSDSVKSSSAGRKVRAMPTRHAGIPLTRSNVRRTASARNPAAATLPVDSASEAKAVIQGAAVLSWRQSNCASTTGSVVAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-03-27" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M0Q5</accession>
    <name>A0A2X0M0Q5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C019g08898 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">BQ5605_C019g08904 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C019g08904</name>
        <name evidence="1" type="synonym">BQ5605_C019g08898</name>
        <name evidence="1" type="ORF">BQ5605_C019G08898</name>
        <name evidence="2" type="ORF">BQ5605_C019G08904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY23106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY23137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M0Q5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.20">
        <property type="entry name" value="DHHA2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038222">
        <property type="entry name" value="DHHA2_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY23106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY23137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="65" mass="7366" checksum="4137EE14FCE3DA07" modified="2018-09-12" version="1">MTNRKLRKVLFAGVQEDQVLKVEKWKGGDVDGLKDEQGWRIWSQGNARATRKQVACAIKGLLARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M158</accession>
    <name>A0A2X0M158_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BQ5605_C018g08617</name>
        <name evidence="16" type="ORF">BQ5605_C018G08617</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY25448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M158"/>
    <dbReference type="STRING" id="796604.A0A2X0M158"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04150">
        <property type="entry name" value="Arf1_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003500">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045872">
        <property type="entry name" value="Arf1-5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 13 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SGY25448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="208" mass="23801" checksum="C9BF9440105C6EFC" modified="2018-09-12" version="1">MGLTFSRLFSTLFSKREMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGIIFVVDSNDRERVAEAREELQRMLNEDELRDALLLVFANKQDLPNAMNAAEITDKLGLHSLRQRQWYIQATCATSGDGLYEGLEWVRSPPRPGLRKQRSRLLITVKVVIDAQLSTTLKGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M1J7</accession>
    <name>A0A2X0M1J7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">CAAX prenyl protease</fullName>
            <ecNumber evidence="15">3.4.24.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">BQ5605_C002g01062</name>
        <name evidence="18" type="ORF">BQ5605_C002G01062</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Proteolytically removes the C-terminal three residues of farnesylated proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 15">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic side chains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.24.84"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14 15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 15">Belongs to the peptidase M48A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.84" evidence="15"/>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY29530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M1J7"/>
    <dbReference type="STRING" id="796604.A0A2X0M1J7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07343">
        <property type="entry name" value="M48A_Zmpste24p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.10:FF:000002">
        <property type="entry name" value="CAAX prenyl protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027057">
        <property type="entry name" value="CAXX_Prtase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032456">
        <property type="entry name" value="Peptidase_M48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10120">
        <property type="entry name" value="CAAX PRENYL PROTEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16491">
        <property type="entry name" value="Peptidase_M48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 14 15" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 1 N-terminal" evidence="17">
        <location>
            <begin position="53"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="16">
        <location>
            <begin position="274"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="430"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU366005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="SGY29530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="475" mass="52448" checksum="EDC642E647826AF7" modified="2018-09-12" version="1">MTSVLKELQWRLQDPRIDYQTIILGVSLAVAAFEGYVGSRQKPYLLESEHPTLPTSLEPYLPAETRQETYKKSQAYALAKHQYSTVVGKLELAQLFLLLSCVLAPVFAWVLPGTGSPPSSVSAPWFGRGHNDWTLLRGAWDLAAKLPGVKGEISTSLVFVAILTVVGTLLSLPQSYYKNFVLEEEHGFNKMTRATFFSDAAKGFILSLVLELPLLAGVIWIIHWVGTDGVLRIVAWIMAFIFSIQIIMIPLYPYVIAPLFNKYTPLDENHAVFPKVKALATRLNFPLGRVWVMDGSKRSSHSNAYFFGLPYLTKHIVIYDTLLEKSTPEEVEAILAHELGHWAGKHVLVLLLTSLIQTGFSLLIFSLFLSNPVLLSSFGFTSSTPFSGSNGTGGPTIIALFLASALFSPLSAVLQFTTNTVTRALEYQADRFAHVLGPEYAKNLKGALVGIHEKNLAVYGVDPVYSAYNNNHPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M293</accession>
    <name>A0A2X0M293_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00103 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00103</name>
        <name evidence="2" type="ORF">BQ5605_C001G00103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY44030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M293"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="432"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY44030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="597" mass="62796" checksum="96AF79C396ED0E7B" modified="2018-09-12" version="1">MTESVSQSPTSKSPTDHPAAGPSQPSSTEVTLNAPVSASFSSSGDDPQRTARNVPSSDLPRSNRSLPGPSSIHGRDFAAKAPGTTLAGSGESVTSSRSSSNPVSGSGSGSATPNLDSRGHQSNEPGDDDDKFGPSHMSNLIQGFAGMIITLPSLFVEVLTNANSASVKASPSVAQAVSETTQKLAESSSSAVHEGVDTALSTSSNIKDQTVGAFEEATNSATTRTTLGHRLSDWFNWSSPKANEQDATVMMDESEILRAQLEQEIDRSFSGSKDEEISVPQTKMPFNLGSSNEGGDAQPARSESSNLDGRDSSSRGERSDRKGRSTDVVEDSTLSGESVKPSEAAHEDEVRRPSPQHAQRAQGSKQVSEKSDSGEVSRKAKGRDEQRHRGEGHRSSPSKASSAGQLEEAKPLQDFEQSADVQFEGDASSIPASTQHSHAASSTLDKIARPQEVQRNAQGNLAQPDQLSGGLSPSGSVAPALPEHLQSPVGYRPHHEREEQSTPARSSFDDLKDRFAKFPSTKGSEQESTGVSLALVQQPQQTSVRRDSPPATLSALPGPAGSVGLAADHKQFEQAAPVDLARSEPHGTWSTAEHEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M346</accession>
    <name>A0A2X0M346_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01400 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01400</name>
        <name evidence="2" type="ORF">BQ5605_C002G01400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY32691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M346"/>
    <dbReference type="STRING" id="796604.A0A2X0M346"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY32691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="285" mass="32210" checksum="A7FB3A3684D80C36" modified="2018-09-12" version="1">MSSRSSTDLSTVIQFACTADEEGAVPFPFCQLADNSADLHVRPVHVTLRDIRPSLQAGQRPTLDVQGFEVIDHVYAGLQEDIDDVWMAEYERQMERVTCGPTSNMQLLCQHLKARRVVSFAGVAVRRRNPELDDAPIDTENLQPSAGAHVDGNIQTGREVCTKVLELSDEDADTERYAVINLWRPLRGPLIDAPLALCDTRTTGSADIIPTLDFYGPGSYIKFSDRQQWYYLRDMMPYEALLFRCQDSTRHPDKGGITPHTGVWDEERRNDSYRQSIEVRCAVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M3G2</accession>
    <name>A0A2X0M3G2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C002g01812 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C002g01812</name>
        <name evidence="7" type="ORF">BQ5605_C002G01812</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY35873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M3G2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019783">
        <property type="term" value="F:ubiquitin-like protein peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="805"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="1231"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="16"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="62"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="431"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="623"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="679"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1055"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1193"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="440"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="631"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1055"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1067"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1200"/>
            <end position="1209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY35873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1268" mass="142317" checksum="9FE99B7C49AE2ECD" modified="2018-09-12" version="1">MAPVALIMSTGEMSQLLQNKGGRPPIALQEQSSPEGYASEVDSEVDEDEDSLQVLAALVPVPSKSSISSPSAVSGLLISPKSRSRDSDEDSADEGYYGVDDDNSDEKSIDNIFSALLLARNDKKIFDRHTYEPSRQDKELSNTTREAIFSNMILTTAEHNELRLRPLVLNCRKPRSGWEFVRKLPVLELPKFMATEKHDWAPRKYERCLAVVERPYGDAPSSTHHQHPSEVAVGIEWRPEVPITLREAWSQPGEGRPVAEVLRITHAVDLLGNDSGDWSRFVGLDSSWRYLNENRAPLTALVATGLKDKLALGRYSRIYLDTVKRLVEEHAAILVRKARENGPNLPGSSPRLPNLLQNAEFILENQWQPPNFMIDKCRTELKRLDTLNDGERGNTVKPSRIARKTLINILYEFRSIIQRFRFIRTSMKQMPRRQLDARLSSKRRSGRSSKNRTHGSTKSSEVVASQQQTNQTSPRSRNWVATAEKKKQLQAKKDNFRAYLNVNCKEHLHGRANKRIDNLVVVLLDNALVYDIWKDVSDAKPDHVLRDTLANSMDIWELGQFRPTEKEGQWVLSLRSMDSSITLDTRAPYYPCRAFKQTGNKCAHLWACDLLVHNGDYHTAMSRSARNRPLQPHRSKKTAKPKLSKSKSNSGVTLEHSGRVDGKATAAIRLLIRDKLNPDQLRPKTSKHTIFENGTTQFGKTRGRPRETKFSNSLSSTKDHAAAKRMAAIPEVIDIEELSDDERPPCQLAPLQEGRLPLDIYDTVQPEERRSNVSAVKDIIKRIPNDVQKVDWDVFLDIHAGDHAPGLNLSSLREMANANLWLRASHIDAFSSAINRFQGQLPFNGRSEEAHDLEPTCYAFYLEGGKCAKGIGGTRPTERQQGVSSDGSSRAYLSIIIDRRPASLFALPLYQIILSRTPVLLFPTHDTNHWILVEARHIRNSLFGRENMRKEANESLDVINHHFLGNAEGHHWRSVTGTEERLITKAAKAGDQPQPDRYPQQTDGNACGAFVCRAMETLVCAAVAKMEPDWSWGPQVEPGRFYSELRDYISSWFSGSPESPTVSCATRDPDNAMDSRKPHGNTQPGDHVGDSDDAEEVSQHHSKFQDRKSNFLALLVPLIPDCHSMILPLFVHYPTHTPGGLSHVGSVQGNNMSTARTRLASDQSDSPLNRPTLAFPSFSPVFATRDIEHLPKKCKHSAVPQGSSPSAVVTPSKRRHSEAESVTPSSSRRKACSQCRDRKLKCDLGHPCSNCTKKRRGKASQVFTCEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M4L6</accession>
    <name>A0A2X0M4L6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">BQ5605_C003g01982 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">BQ5605_C003g01982</name>
        <name evidence="18" type="ORF">BQ5605_C003G01982</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY38230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M4L6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="17">
        <location>
            <begin position="41"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="322"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="SGY38230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="828" mass="91393" checksum="73DC8279B5C0564D" modified="2018-09-12" version="1">MIAAGLLDRFGAGYSDKDVEEFVCNACLGSKGHRLPFPDSESHSPERLGLVHSDVLLFPTPSLTGKRYLVTFLDDHSRKLWAYVIDHKSNVFPTFQTWLADVELETNARLRVLQTDNGGEYQSNAFTEFCKSKGIHRQYSIPYTPQQNGCAKRVNLSIVEGVLALLADSHLPATFCDEAAAYFVYCKNRCSHSALAKQTPESVLNGQRTTVTALHPFGCAVWLTVAPDLCSKLDPKAARVIFTGYDLASKAFCFFDHSTNKVVIGQNATFLDDDFPGLPINTPVDADDTERQFVIPADTPAPAVKTRTPLVSPLPSPLLAPFSSPATSSAGGPSLDDSDDPLDLLNSDTAVRLNLMNIHRSDDDTLVTPAPAIDSVEQPSNDDSPDEIDFLSRHHCAFIATENDDPTLEAIEPVKSITSDPQTWREAMSSDEHDIWAQAAAAEFTAMRDDFKVFTIEPCSSVPPGATIVTSKFVWKTKRDARGDVTGRKARLVAQGNRQRDGIDFSETFAPVARFSSICCLLALAAANGYHVHQANIDKVYLHGELDHNIWITTPRGFDFPSDKVLRLWRSIYGLKQAGRIWNCHIDTSLRSLGYKATGTDHCIYSHIDDQQRPHYIALYVDNLLIVSPVLNEIERVISGLEQRYGVKRLGPAKYILGIQIRRLDNGSIALSQERYIMDVLARFHFDTTTRGATVPMTPGLSLTAVPGQGTERIRSWYLQAIGSLLYISLGTRPDIAFAVSYLSRFANNPGRCHWIAVKHVLCYLRATYRDELLYTRGPAKVTGVVGYSDANWGACVDMSISTMGFVFYLAGSAVSCFRNLGPEAQCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M4Z2</accession>
    <name>A0A2X0M4Z2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C003g02364 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C003g02364</name>
        <name evidence="8" type="ORF">BQ5605_C003G02364</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY40379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M4Z2"/>
    <dbReference type="STRING" id="796604.A0A2X0M4Z2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="17"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY40379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="326" mass="35828" checksum="908F8F0BA2A1E310" modified="2018-09-12" version="1">MGWEHVWLLDGHRIPEIGYGSWLIGSGSTVVDQVEQALETGFNHLEGGQDSNCSPARGRCGGTWDRTAQIYRNESEVGDGLKASGLERKDVWVTTKWSGKDGKGIRASINESLEFLKLKYVDLYLIHSPRLAKADPVAAWEEMLVLKKEGLAHSVGVSNYEIKDLEVLREAGLATPVVNQVLLHPYVYDKQKALLAYHEQEGIVTEAYSSLYPLTHQSGGPLDKPLRKIAQAHSGEKVAVTEAEVLFAWARSKGAVIVTTTRSKERLHAYLRAGDLELTEKEIATIDSAGSQLKAWQRWQYAKRAGALVAGCAAAQFVYTAVRAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M549</accession>
    <name>A0A2X0M549_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g02424 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C003g02424</name>
        <name evidence="1" type="ORF">BQ5605_C003G02424</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY40800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M549"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY40800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="77" mass="8468" checksum="4D4C05E88EC5A3A2" modified="2018-09-12" version="1">MNMTIAELLAFDVAPADASLHIELSKDELTHYSTLSATRGHFGLSSRVFGSTQPTHLKLPPQVVDARDTNFSLNWPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M5M1</accession>
    <name>A0A2X0M5M1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g02413 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C003g02413</name>
        <name evidence="1" type="ORF">BQ5605_C003G02413</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY40712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M5M1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY40712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="357" mass="39112" checksum="FB7E6783B371BEDB" modified="2018-09-12" version="1">MFGSATDQSIVQLDRVTALAAPMPQINVASTKAILGPFFGNINAGNWSLAKEQLEMALESDEHLVPLQTVTPLPTMLTSHAFTKDSVLDAVGWYNHQQSHHQAKAKQAATIKSAKAHLMMCVGQATYDTVKDLPAHQQWVKFKSVFAATSSTVDRSARLVELVTMPQFVIGDDFEAWLATFRATVNAINNAVKHAQPSTAPCGCDPDPLHPMIVRDWLCNLMPEAYAPTINALGDDVDIGKLDGPGPRDPPAKCTGHTGPHLDARKLHNIAKWPPGVSKRGRLGLFPTQCFLCYKDGHLATACTVPDHLRIKSKVTILVTQETLGREETKPASLFSSRLALHRIRCVLRVFMPQYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M7G3</accession>
    <name>A0A2X0M7G3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C001g00478 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C001g00478</name>
        <name evidence="4" type="ORF">BQ5605_C001G00478</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL34 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY46877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M7G3"/>
    <dbReference type="STRING" id="796604.A0A2X0M7G3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.370.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008195">
        <property type="entry name" value="Ribosomal_eL34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038562">
        <property type="entry name" value="Ribosomal_eL34_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10759">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01199">
        <property type="entry name" value="Ribosomal_L34e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01250">
        <property type="entry name" value="RIBOSOMALL34"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY46877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="114" mass="12690" checksum="40C948DFD29BDB40" modified="2018-09-12" version="1">MVQRVTLRTRKSYNTKSNGKRIVKTPGGSLRYLTVKKAASAPKCGDCKIALPGIPALRPRQYAQISKRQKTVQRAYGGSRCAKCVRDRIVRSFLVEEAKIVKKVLKSQTQGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M9H5</accession>
    <name>A0A2X0M9H5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C004g03000 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C004g03000</name>
        <name evidence="3" type="ORF">BQ5605_C004G03000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY69340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M9H5"/>
    <dbReference type="STRING" id="796604.A0A2X0M9H5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045046">
        <property type="term" value="P:protein import into peroxisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006966">
        <property type="entry name" value="Peroxin-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28080">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28080:SF1">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04882">
        <property type="entry name" value="Peroxin-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY69340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="617" mass="68049" checksum="485C08C9EB9621D1" modified="2018-09-12" version="1">MLASFASGTSDFFQKRRRGLTWVIGTIGGAYLVGQWGMKKMGEFAERQRKEGIEKDNLSKRFNLNLQDSQFTVLALLPTVARQVLDEYDVDACWKELRMIADRAKQDSERRQREEQERNETEKKKVEGTWAELVKGNEGKEQSTTVRESEEQHKANGTWAEVVKEANNGEAAAADDIQVKKEFVEVEDKGSETWAEAVKGHAAGQPTAGGSGTAAEAYTVGQTQQNASSSGELAQEPQPASASSDIAAPTAETAHTDNGMVESTAGLSKSWAQVVVNGEGQLVEKDQENPTTVSEIVGVAEAEPKLPLRTRAELWNDIKLLSFTRTITSIYVLTLMTLQTHVQLSLLGRSAYVASVVSTLSAPSTLDKAEDDIVVDFNTDWDLEMALYGEKAQTSDQVGVSKDTERKYLTFSWWLLHKGWRLIGDRVQRAVNKVVGPMGLKSPIVYGELSTLLGQIQNQIETDEDGTMFDFSAVLFPSSLEDEVKTLTAGGIPTISATINPELRRLLSETQDCLDSSDGQLVRQRLLDAMFTRLVLGLEAPFQSPVASMGQGSRFEDVTERSTILAKLLPVLAQHSHNVLSGMSNEYVEAMEDVRELREFSAIIYASFDRENVRETC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M9Y9</accession>
    <name>A0A2X0M9Y9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="26">BQ5605_C004g03153 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">BQ5605_C004g03153</name>
        <name evidence="26" type="ORF">BQ5605_C004G03153</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY70463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0229">DNA integration</keyword>
    <keyword evidence="20" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="18" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="21" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="17" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="18" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="19" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="25">
        <location>
            <begin position="206"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="25">
        <location>
            <begin position="1368"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="435"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="500"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="893"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1650"/>
            <end position="1696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="435"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="500"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="893"/>
            <end position="924"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="SGY70463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2264" mass="248033" checksum="370CE77046863F28" modified="2018-09-12" version="1">MLADAPSCPACRAPGHRLRDCTSRAKHPPTGPCRRCQKRGHWALDCKNRGQQTRTSDDTQDDLSSSTAHRPNIGYFASRLFARRQLPTDAFVVDSGATTHMVADRSLFTTYRPTAHTKIGGIAGGITAIGMGDVAIDITKDGQAIAHVHGLTTVSTSWTRITPNKMIAAGLLDGFGAGYSDKDVEEFVCNACLGPKGHRLPFPNSESHSPERLGLVHSNVLSFPTPSLTGKRYLVTFLDDHSRKLWAYAIDHKSDVFPTFQTWLAEVELETNARLRILCTDNGGEYRSNAFTEFCQSRAFVANTLFHTRLSKTVGAERVNLSIVEGVLALLADSHLPATFWDEAAAYFVYCKNRCSHSALAKQTPQFQARPQGCARDFTGYDLASKAFRFFDHSTNKVMLGRNATFLDDDFPGLPVNMPVDADDAEHQFVIPANAPAPDTADTPDAADTHTPAATPAPAVKTRTPLVRSAHMDVSSPLDDSAMSAVDVAPGYTGGSLLNSTDTSPLLSPSLAPISSPATSSAGGPSIDDSDDPLDLLHSDTAVRLRLMDVHRSDDDTLVTPTPAIDFLSRHHRAFIATDDDDPTLEAIEPVKSITSDPQTWCEAMSSDEHDLWAQAASDEFTAMRDDFKVFTIEPRSSVPPGATIVTSKFVWKTKRNAQGDITGRKARLVAQGNRQRDGIDFSETFAPVARFSSIRCLLALAAANGYHVHQADIDKATFTASSITTSDDDATRFRLPKRPERGWDLGARGEPGPLAQPRGSLAVDLRARLFCCYKPTSYQPRRLRFFSLEPSHSSRIRPRSKAFRFFDHSINKIVLGRNATFLDNDFPGLPVTTPVDADDTDRQFVVPADTPAPAVKTRTPLVRSAHMDVSSSLDDSAMSAVDVAPGYTGGSLLNSTDTRSSSSPSLSPFSSPATSSARDPSLSDSDDPLDLLSSNTAVRLNLLDVHRSDDDTPETQAPAVDPVGQPSDSLPLWACQMAPLWFLSCSSNFLVWSPLVLRSETYHCLSRLLAQPSYQCGHLRARPSLYFFTLRNMSDAGASAPEAKLREPTPDAPPLRPPTHSAAFATTELLCNSSGYRDWVLAIRSRLPSGVVRYLNTGVPLESWPASYVPLWDHYACSSICASVDSQTVLPGLSPYLDESLAAPKVWQALRERYGTVSAVDLLPVIQRLFSSDLFENDARLLQDSQVTVNALLASHLLARLPSSFDAWRTTFVADQGDSTAMPSATEIFTRLYRDVKARPVDTPVAAVATPQARHGCSRPCPNPSCRKLHWLRECPDTAWAAAYRARRTAEKKASQPVASPTPCTPKALLAVPANVSLLTLHRRLAHLPVAQIKNIVQSGLVTGVDWVYKDQELRDFYCNACLASKAHALPFARSKSIASGRLDLLHVDVAQMPRPTFGGHRYMLVIIDDFSRKHWCILLALKSDVFPRLRDWILEVENATGNKVKTIRSDNGGEFTLRNFVDFCASKGIRRELTIPYTPQQNGRVERSNRTIKEGILALLYSSGADSRLWGEAALYYVHCKNLMPHAGIGGEIPDTRWHGFAPDISTLRAFGCRAWHHLPSAKRTDLDPKAVPLLFVGFDQHAKAFRLFEPSTRRIQLSRNVVFRESEFPALRPATDVRAEPIPLPVPVDAYPDQVDPLEPSLVASPRSLAPRAEPPRPVPAAPDQGPHRPALPASATLTRSVRLPGPDRSPATPTRCCFAMPGAGFPDDVDDALHSPSAVAYLASGAAALIETSPADPAELIAPARDPPHWRAAMATPQADEWRLAARDEFDSLLRDFSAFTPIDESLVPADAKVLGSRFVFRTKRDQHGQVKSYKGRLVARGDSQRSGIDFDETFAPVAKFTSIRALLALAAAHGYHVHQADIDKAYLHGKLDAPLYIRVPDGIYMPGKVLQLHRSLYGLRQAGRIWNDEIDSALSALGYVATESDHCVYVRTTGDVHHYVALYVDDLLMISPSLPEIERTLQGLEQRYGVKRLGEAEYVLGIQIRRSPDGSISLSQEQYLKDVLARFGMSDAHPVATPMQPDLRLEVELQPTPFPDRTRYLQAIGSLMYASTGTRPDLAYTVGYLARFSHSPSAAAWGAVKHAFRYLAGTLSHGLRYARGNPAPLLGYSDCNWGACVLSSKSTMGYTFVYAGAAVSWSSRLQSRVADSTCDAEYLALSHAGKEAIFLRQLFGELGLSSSKPVLIYGDNQGANALTKNPVFHARTRHIRLREHFVRDMVSMGDIVVQYINTGEMTADIFTKALSRDLFARHRGRLGICAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MBC2</accession>
    <name>A0A2X0MBC2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Formate dehydrogenase</fullName>
            <shortName evidence="5">FDH</shortName>
            <ecNumber evidence="2 5">1.17.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NAD-dependent formate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C010g05982</name>
        <name evidence="9" type="ORF">BQ5605_C010G05982</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>formate + NAD(+) = CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:15985"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.9" evidence="2 5"/>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MBC2"/>
    <dbReference type="STRING" id="796604.A0A2X0MBC2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042183">
        <property type="term" value="P:formate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05302">
        <property type="entry name" value="FDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000057">
        <property type="entry name" value="Formate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03210">
        <property type="entry name" value="Formate_dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033689">
        <property type="entry name" value="FDH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005750">
        <property type="entry name" value="PRK07574.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938:SF9">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="7">
        <location>
            <begin position="34"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="8">
        <location>
            <begin position="128"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="173"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="229"/>
            <end position="233"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="310"/>
            <end position="313"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="5">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="5">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY13808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="361" mass="39563" checksum="BD950912ACE0D39E" modified="2018-09-12" version="1">MVKVLAILYDGGEHAREQPRLLGTTENALGLRDYCKEQGWEYVISSSKEGADSDFQKHIKDADVLITTPFHPGYLTADLIKTAKNLKLCVTAGVGSDHIDLNAANERKISVLEVTGSNVVSVAEHVVMSILLLVRNFVPAHEQIMAGDWNVAAIAKNAYDLENKVIGTLGAGRIGYRVLERLVAFDPKELIYYDYQALPEDAAKKVNARRVEDLKEFLGQVDILTVNCPLHESTRGIINKETLSYLKKGAWIVNTARGALCVAEDIAEALESGHIAGYAGDVWNQQPAPKDHPWRTMKGPSGNGNGMVAHYSGTTLDAQERYASGTKKILENWRTGKAQTPSDVIVADGQYQTKAYGQRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MBH3</accession>
    <name>A0A2X0MBH3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C008g04916 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C008g04916</name>
        <name evidence="3" type="ORF">BQ5605_C008G04916</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY78698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MBH3"/>
    <dbReference type="STRING" id="796604.A0A2X0MBH3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="175"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="904"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="383"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="684"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="807"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="321"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="954"/>
            <end position="975"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY78698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="975" mass="106029" checksum="EB726D35B53B5E09" modified="2018-09-12" version="1">MSFKTEPLAWTPTTPAQDRTDLTTAMPPLTSTALPSGPPTGASPSSSSPPAPLSLSHADPSHDQPATPSRASTSTPSLDVYAAKNLGSTSHIQPTVEFRFTNPHRPAGAVAGVGHTAGSSAASALDERGRTNPATLSKTHAPSFERFRKDSFINQFRLAASGGVIGSAAVIARPFSSANSSPRASTPQEDTGRGNDSKASTWSGASAKKDALRQASSIAGASSTSVVTQNSRLPSSPDVQRDATTRSASPRTPSNSRPSSVAPPVVPEGKEHPENNPPAPSKPKKPLAEDRASLSGSVQGAAPTGSGTSGMSLQKPGAGHRGLERSKEEPKSKRIKTSGGTNGGSGSATETGRTARPTTAQDNPLAMQAGVMQKLSTQMYNENLEYKRRLEHTEKRVRALEGEKQELKQTVRTKVETALEKSVARLSCPQKLGAQMAIFFSRYVQAGLAMAQTQKNFQDVAERLNRESDLRELEELRREIQDSLGSELHGALSPSLLTVFIRTLFFGLCLTALQREYTNSSGSLTLERIESTKLEVIRQQQQELKNRDDVISLLREKLEMNTGLLAEANVQRSALETQVGKLEGQVEHLQGVVQGLVSKSEAERAKHCQEVQERDSIIAATTSEKEKLVTELEAWKTRHETVTRRKEELDQSHIKKDDEIKQLATDLHTERMELGRLRGENEGQERELETLRPLREEIEEARAELAKHRSQSDQIIQGLRADLSKLEDLVATKDEEIQSQATTNAKHVERISNLERTVSNLEATNQTAALQAVNLNNTLEASQQHVLALQADLQRQRDTNLSDQLELAASRKNEINLEHELEQVKKARDEASERCATLVTRQEERERQKVDEVMALMERELAKRDADLANKEGELKRAHNRVGVEERAKQKALLQIAKLKQRPVIENDVGSSPNGSAVKEREGSGEEGSELTGAQAHGDSPTLNALKPPAIPVRASRGSARRAASATTMASSSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MBS5</accession>
    <name>A0A2X0MBS5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C008g05016 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C008g05016</name>
        <name evidence="1" type="ORF">BQ5605_C008G05016</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MBS5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY79027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="388" mass="43058" checksum="ABF97806F8A799AC" modified="2018-09-12" version="1">MVRFGNYRPLGWLNEPSRLTSRLPLRQPIADTQITQIQLSWSTDEPLEFDTLPRPLDAWTDKFKDRGAITAARKQGYRSIAIAGHRLPFGVESIWRHIDYAERMRSIVISSQNAFLHTLLDFGQRGLEKGLVVLDPKEQKSVENAVRSLAALGLNNDAALLAVQQAYDEADAQAEERFLLDVIVTANESLPGSAQIIRLPSLLRYESRQLALDLKSLIQRRRAHQCFHLRAVLLKGRHGATTSTSQVSDPTSKAKLSKHGEMHSSVLRGLVHSMGAARLEAVSGVARSIRWTGQATFSRFSTANETENIGYIEDRRKEVRMQLRARQYTAFAKIPAFGSIDGNVTSATPLKIGSLVCFVLKRGIIPASCASNIGEEQLSIGLGSYISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MC16</accession>
    <name>A0A2X0MC16_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C007g04764 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C007g04764</name>
        <name evidence="2" type="ORF">BQ5605_C007G04764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY62993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MC16"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY62993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="75" mass="8184" checksum="A6547663C7D87BA8" modified="2018-09-12" version="1">MPLSFLPLLSHQPLSHPYPSTVPLPAPFTQLFRPLAQSGLALLIVNTFSNQLSSSHNRHRGARKITAPGEDKQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MCQ2</accession>
    <name>A0A2X0MCQ2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Synaptobrevin homolog YKT6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C004g02707</name>
        <name evidence="13" type="ORF">BQ5605_C004G02707</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY66796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MCQ2"/>
    <dbReference type="STRING" id="796604.A0A2X0MCQ2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15867">
        <property type="entry name" value="R-SNARE_YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045848">
        <property type="entry name" value="R-SNARE_YKT6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806:SF1">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Longin" evidence="11">
        <location>
            <begin position="12"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="155"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGY66796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="222" mass="24963" checksum="A00574CC09CFE908" modified="2018-09-12" version="1">MKIISIQILAVEPARSAIPAVPVAAALNLSSFSFYQRSVISQFMDFFSRTVAERTAPGQRQSVEQESASTAYTAHAYTRASDNLAGVIITDQEYPVRVAFSLINKILDEFTTQVKRDVWEAKARESRQAGKQYLVEFPQLQEYCTKYQDPKQADTIMKVQQELDETKIILHKTIESVLERGEKLDSLVDKSAALSASLAPLPRRSKNFYKTAQKQNSCCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MCW2</accession>
    <name>A0A2X0MCW2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C004g03039</name>
        <name evidence="8" type="ORF">BQ5605_C004G03039</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Vacuole membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ATG22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY69611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MCW2"/>
    <dbReference type="STRING" id="796604.A0A2X0MCW2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF5">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="35"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY69611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="354" mass="39310" checksum="591750F5DF6A2E7B" modified="2018-09-12" version="1">MIWHSDSATGGCELPQRRSQSLFVHKLQHLHLDTMQDREPKSLQAKKDEEHHLGNSSTGDNDLDQLRAKNGGVAQATVVAAGGIVLEEIETDPEQVTTRWELWSYYVYYIGNSGLGPFNFGPTQFQNLLYYAGHNLGTNDPCDSSVAWCSLLSVKPNETSAPRFLSRTVIFLMIGSYADYGTWRPWILIFWTTVAIAVSFAWLGVDTPDKWQAATALYIIGLIAYQGALAYWTAAFPRLSRNLPEMQQAQRDLVAGETTLEAFNTLDMMSRNRLSNIAFAVCSLGEVVVLFILAGILYGIKANGSVVQNTRALSIVCAYSAAVWILCALPWFILEKHRPGRTLPPGTNYFTVGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MDM2</accession>
    <name>A0A2X0MDM2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C005g03311 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C005g03311</name>
        <name evidence="2" type="ORF">BQ5605_C005G03311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY73661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MDM2"/>
    <dbReference type="STRING" id="796604.A0A2X0MDM2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013877">
        <property type="entry name" value="YAP-bd/ALF4/Glomulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040347">
        <property type="entry name" value="YBP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28020">
        <property type="entry name" value="YAP1-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28020:SF1">
        <property type="entry name" value="YAP1-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08568">
        <property type="entry name" value="Kinetochor_Ybp2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY73661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="591" mass="66126" checksum="7F76BE00BC27D8FA" modified="2018-09-12" version="1">MSTQSHVTPNPSWQDRLDQALSRPGPGPASTAELEALVSELERHAQAIQRQDGPSSLEHTPFDDPFPPLLLLTPLLALPADSAKAQLAQEAVNLFASHASAKEVVVALEEKIAQLGQASQEQRHVDEDSESGNDNEEHGRDPSPHSQLRELVALVDIYAHVFPRIKTAKPSRFLETATASVTSILRIHCAIHPVTASDAVVLAKMVVDFTETIITKTTWSDAQQQECHVLLRSHLFETAFNLALFFPVSLAETYFYSQVPHRRIPHRATPTLDPLVQQAWSTLIDFVRDRFYLELAQLFALAPSNRGAFELFIQVLARDPEDRIWVKTMGEDPEGDLNNGVYSRLLRKTLGLLIGIAREGSSGQGRVDEALFWLWWCVQGAAQEGEVVDEEVFFPLVEIISTLTSLSPAPSRRFIAFSLLTTLVLDLVPTEATQILSLKDLIETCPYSSLRSASIGILRKVLLRKFNEVDKLRNGIDQEKGGLWLSPLLLIEFEELFKIGPFDLNKFEEADEDRTKTIHEQLSLLYLLLSRDEADQTGIWKGFAKVEEEFLRPLRKRMAREEAGGVLGWGVLEVGLERVDTVVEGRGKRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MDN9</accession>
    <name>A0A2X0MDN9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C004g03037 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C004g03037</name>
        <name evidence="2" type="ORF">BQ5605_C004G03037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY69600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MDN9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY69600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="93" mass="9469" checksum="0099AC506376A9BD" modified="2018-09-12" version="1">MSRIPLPSSPSIQINGTPTSKDTSTGSVMSSSSASYLNSPSSRVGAGAGTRASSSDAGLADTRKRVSKKDEVSVTFFPSSWGRSSGRERGGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MEV9</accession>
    <name>A0A2X0MEV9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C015g07962 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C015g07962</name>
        <name evidence="4" type="ORF">BQ5605_C015G07962</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY18045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MEV9"/>
    <dbReference type="STRING" id="796604.A0A2X0MEV9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12285">
        <property type="entry name" value="RRM3_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034393">
        <property type="entry name" value="TatSF1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15608:SF0">
        <property type="entry name" value="HIV TAT-SPECIFIC FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15608">
        <property type="entry name" value="SPLICING FACTOR U2AF-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="160"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="246"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY18045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="481" mass="52685" checksum="8E0C7016E7605021" modified="2018-09-12" version="1">MNPPHLPSQPQPQPQTQAQTPPPNTAAATNSFASDPRVHFSLADQKWVFEADDGSEMEWDAVRGAWVPRLGEEEVAQQQAAYAVHGVDESVPAAPVLARQNGKKRKADQVTPQQTSTEMNYNDDDNNNSSSSSIASTSNLSGPPAQNKPNKKARPPKTNTAIFVSHLPATATIPLLQTVFSKAGLILEDVDGNPRIKLYHDETTGLFKGEALIVYLQAASVDLAIRLLDETELELGKGQQVMKVSEAQAWRKKSGTAGEGDADDKGNSEGKRKPKRTELEKKKLSKRAEKLNQRLTEWSSDEDDNSAAIVARARSNKVVVLQGMFTLKELEEDPTLLLELKEDVRDECETMGTVTNVTLYDVRMACISSDCSVATKDSSRCWHSQQEEEGIITIRFKDEVSAQACIAKMNGRFFGGRSIVASVLDPKQKYRRTGQGVSLEGTGLDLEADEEASKAEKERLARYAEWLEKGGDEEGGAEKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MG00</accession>
    <name>A0A2X0MG00_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C035g11419 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C035g11419</name>
        <name evidence="1" type="ORF">BQ5605_C035G11419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000064">
        <property type="protein sequence ID" value="SGY97695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MG00"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY97695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="46" mass="5089" checksum="CB730E6967C4C2D8" modified="2018-09-12" version="1">MRPWSTSNQHACTLKGGGTLSKVDGSALPHPTCSILIHMMRLRHNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MGH8</accession>
    <name>A0A2X0MGH8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Mediator of RNA polymerase II transcription subunit 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Mediator complex subunit 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BQ5605_C008g05011</name>
        <name evidence="16" type="ORF">BQ5605_C008G05011</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9 11">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the SRB8-11 complex, which itself associates with the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the Mediator complex subunit 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MGH8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009401">
        <property type="entry name" value="Med13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051139">
        <property type="entry name" value="Mediator_complx_sub13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021643">
        <property type="entry name" value="Mediator_Med13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041285">
        <property type="entry name" value="MID_MedPIWI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249:SF3">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06333">
        <property type="entry name" value="Med13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11597">
        <property type="entry name" value="Med13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18296">
        <property type="entry name" value="MID_MedPIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0010">Activator</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med13 N-terminal" evidence="14">
        <location>
            <begin position="370"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="MID" evidence="15">
        <location>
            <begin position="1421"/>
            <end position="1582"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator complex subunit Med13 C-terminal" evidence="13">
        <location>
            <begin position="1619"/>
            <end position="1936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="795"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1172"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1209"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1323"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1780"/>
            <end position="1821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="21"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1175"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1213"/>
            <end position="1230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF11597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SGY79008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1947" mass="206548" checksum="AA9F01850C36AB3E" modified="2018-09-12" version="1">MAPHPLPARPIQSVAGAATPSWPSLAQPPLSTGATTHQQAARNQAGTTGFSTTLPPPPSAVQPIPRLPMPPPPYSGPASAAAQQSLGQVYSQSQSQGQSGPLPLPALDAARSSSFQGNATSPNGSNTPGSLPASPKWGTSGQHLPQSHQQHHLATPTHTPNPASSSTPSFALPRAPSMRKALTSQDVRVNSVQVDLPGQGRWKVHWRAWRGPALLDTSVAAPPTPPSTTNVSDKALASHLGMPLHEHTPTAKYDPLASTAPTPTTTLKRARSALGDDDPSTSIPVASTSSAPGLSLRARLQGLQKVDPSQDPIELALKQVQRVAANLTASASNTVSSAVPSLFSYVRISAVRPIEDFKGKGKEKATEAQDAAVGRMLWVFGLSSDSIEHDPTREALSALEFADLICVGKGHFAHRDVFPAMYEMTTSPSTSDAKTAPSQPASVALPLALPASAFPSVLSLSAQFHADLPCPASAPQPQTRICSPCEAFLAGFGSVIRQSLLAQEDGHSSSELRRPALPLGSAIVILPPASEPFGYSGRRISPEAIKTTLHLSLNLQGLLVRSAVEDVAYRPYPVLSATVTPVPTGAPVLLAPLGTPATFIRTVASSSHSLHASRVDASLRQTWLNALGGLDLALDEHEHWLVCRILIPPHGTTANMSPQVSVSSPEHLDVMWPASLCLLDGTRSQPLRSPQSTPPRPKAVDLVDSLSLDPFVRTTFETGLSSPDVLTRQQLAAALHRGLAADAVNPHKSSSSTTYHDPIRARVEQVGTLFVELQEQQEQRLRLDREAEAVRASTVAAATTAPPASPPVAEPGKLNSTAAPISMRTPISLVGGSTEALSPGDAFSAAERSLMSALGEAPFASTDPATMQASNASALTTIKNAEMDHLYPSPFEAPNALPIVSEGVGSDSVMNTVELGSSHDATFPNFDWGEDFSAGQNPGLRHNQDFDDGMMMDLNDDDFSFFDDPAPLPTSLPLGTLAGLQSAGPSPKFLDHFSHLGSGATPFPSVASPASPSLGIASPNVHTSPAVLSFSFDNSQSHNALGLGGTTPRAQLAEQSPFKTPRTPYTPYVEVVDEENEPESAHSGTHATATVSVAGTPASTALALKKLTQFEAVPFGSSHAKADDRYDPRKGKFGLPSPGWDHKELPMGKMSNALASGVPWLTAMCDPRANAARQLKQKRTPSLAKKRPGTDGTSYPCARVQTRDRKWIRFTEVDSDNPGEEDSEDDDMDGPVEPQHHGGDDLVATETGPSHRAPENFFGSGLLILRDHLNRMLSTTGAKVDIIAPVPVATKATKAAEHALETTVGLMADQTLHNPDFRNRSAALKVRSKSSGAKGESTESLNGDEMRGPDAVVPLFTASSIATRIVYNLLTRVAPNPDPLPLSTLHAPTLLLRAQQTIMQLSTSALDFWNPMGFEPLSGPKDVTAFAVFEELNTDTREAVASWLDDVSEGYQSSRLGRHELGHIAASGTFSGVENGLAALPVGALSRVRDDYKGMANHLVDAARTRKHVVIYLLDPSEASRTSASAAPSIIAALAHILKSRASTMSLVVYPLPLSTVSRWRSIASADSIAARLRRLAFAVYDTLLVSVSSLPAPVPETFPSSQIGRHPVLGPLTRLYQSPAITASPVRETSIEFALVWPPSSLEVLHRHRLLHVAYGCFCAPAEGERGPALEWIVISGIDEKGETWKSVPQIVRYPPQMQLEEARARQVWKAAKSLHDTADIEWRVVVTKLGNMSKEEIIAWDKISRDIISALRRPLHITISCAEIGPALSMLPVLHEASEHTSSPMSEEGELGAGNDAGTTMSPALGRSHAGRTRNQSKPIHLDSGTCLFVHTPNHPITFDTSASLVAPASSFLIHAPRLPTFAQAPFQPFMPASPAISVLALHVLSSACTKTSTLRIDLSQHVADIMQSFADLAALGHARWGASGRVPWHLEAVASVLDILAALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MGI4</accession>
    <name>A0A2X0MGI4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C034g11304 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C034g11304</name>
        <name evidence="1" type="ORF">BQ5605_C034G11304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000065">
        <property type="protein sequence ID" value="SGY99791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MGI4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY99791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="573" mass="63996" checksum="B79AEFDADF23B272" modified="2018-09-12" version="1">MLNAALAIRFRTRNQATFGGGQQKEGARHTDLELTQPHHFLTCCEQMAVKKKGQAAARGMLVPIRFGMLLQGGHAKRTTFVPSPLVEVVLDLAQHAQRQPTRMYSPGLAITQTAAYLVVLDHEACRIATISDCWGEGSGELGVVLSILFGLDVYSAGFNPLFRYACHSNSGIKPVSFLASCLRPPELEEGAPLVGRIVEFIDEEPIELVHSTLRDDGSIFSRSTVVLQLTRPSLVAPAGSASSPSNSTPSFVLKVQYNTLNYVGHEATVLQKIEERCASIALPEESSLIFNHISLLEKPKSFGLHYLQIKDEDLPVRRDGQDAHQRVLRRKLDLLILRNPTPLPTRVHGHRHCRHPMSDAFYVLDRLFTLLPVLYDLGIHHRDLSLGNILHHRGHLVLVDWDSGIVAPPGELVRCAAEDCGSARFTLDTASSGALFWLLTKRDKAVAERDLGDDLESVVYWFFYIVGSFLEFLSPPTWAAWYSMYLTWNHGLPDLAPLYAARLDLWGDIVSDRQERVDLNAMYRLSPVEGRLLAMLTRKIPDFPMGSVQTKEEMAKMQVKMRKILGLAFQPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHI9</accession>
    <name>A0A2X0MHI9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C032g11105 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C032g11105</name>
        <name evidence="1" type="ORF">BQ5605_C032G11105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000067">
        <property type="protein sequence ID" value="SGZ05035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHI9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ05035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="380" mass="42956" checksum="6041B4EFE3EC1F59" modified="2018-09-12" version="1">MYLDDPDIELLDDDFERMAPFLNVRVSRASRLPLRQPIADTQIQLSWSKDEPLEFDTLPRPLDAWTDKFKDRGAITAARKQGYRSIAIAGHRLPFGVERIWRHIDYAERMRSIVISSQNAFLHTRLDFVERSRREPEERKSVEHAVRSLAALGLNNDTAPLAVQQAYDEADAQVEERFLLDVIVTANESLPGRAQILRFPSLLRHDTRQFALDPKSLIEHRRAHQCAHLKAVLLKGRHGVPTSTAQDFDPTSKAKLSIRWTGLTAFSRFSTANETENIGYIEDRRKDVSCNCALHIWPRECSSIISILAQIRMQLRARQYTAFAKIPPFGSIDGNVTSATPLKIGSLVCFVLKRGIIHASCASNIGEEQLSIGLGSYTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MII5</accession>
    <name>A0A2X0MII5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C018g08682 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C018g08682</name>
        <name evidence="3" type="ORF">BQ5605_C018G08682</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY25931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MII5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="176"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY25931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="236" mass="26392" checksum="88ACC051D1D9C9FB" modified="2018-09-12" version="1">MYAVEPLQEYELADRALRPALIPEPGVPLLPALPQVSTSSFSTRTMVRSLLFLYQLAARWPKRLKTKEEPIDHRREEAVEAVNSYEDDDPAERDPPLPPDDGHEYRPYRVGRTPGLLKNINEGNTLPLIALVSTRHPPLPKTFKDAMASPEAESWYAASVKELDSMGLHKAFKQVSSSSTGARALGYRWVFTRKEDAEGNIINYKAQLVVQGFAPRVGVDYNKTLALVSNPEGHEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIJ2</accession>
    <name>A0A2X0MIJ2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C009g05722 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C009g05722</name>
        <name evidence="1" type="ORF">BQ5605_C009G05722</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY84850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIJ2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY84850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="61" mass="7298" checksum="021776AC4B151726" modified="2018-09-12" version="1">MYLFVSPIFLRRRARFSRQISASNHDQKLPPVILNLEPQVPKQLTIARQASQNYSYLFHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIQ2</accession>
    <name>A0A2X0MIQ2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Decapping nuclease</fullName>
            <ecNumber evidence="6">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C028g10505</name>
        <name evidence="9" type="ORF">BQ5605_C028G10505</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside-ribonucleotide in mRNA + H2O = a (N(7)-methyl 5'-triphosphoguanosine)-nucleoside + a 5'-end phospho-ribonucleoside in mRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66928"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17313"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:172876"/>
            <dbReference type="ChEBI" id="CHEBI:172877"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:66929"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60880"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:60881"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78683"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78684"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DXO/Dom3Z family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="6"/>
    <dbReference type="EMBL" id="FQNC01000080">
        <property type="protein sequence ID" value="SGZ12437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIQ2"/>
    <dbReference type="STRING" id="796604.A0A2X0MIQ2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034353">
        <property type="term" value="F:mRNA 5'-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110155">
        <property type="term" value="P:NAD-cap decapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013961">
        <property type="entry name" value="RAI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039039">
        <property type="entry name" value="RAI1-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395:SF9">
        <property type="entry name" value="DECAPPING AND EXORIBONUCLEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395">
        <property type="entry name" value="DOM-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08652">
        <property type="entry name" value="RAI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RAI1-like" evidence="8">
        <location>
            <begin position="78"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGZ12437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="481" mass="53593" checksum="CDA19E6B238712AD" modified="2018-09-12" version="1">MSPSSTIPLVHDERPLKRRRANSFDKAPSTPLVLSPAPGPLSALTTPPLSKPRKSYYHLITTPLNPLTAPPTRPIAFQQPLHLTSFSYSPTRQLLLTPQDRDASLAVYTPPRIGSDLNTGFEQAVWRDDSGDEGLDALLQHYVESDPAGAAGEMLDKVNIITWRGMITKLLLAVYEVEAAHNDAANSRRTRAEGWEMNVMLLGNTLYLEESKTPARLEAKAASEKSYLRQSYYGYSFEAFSTRSPQSTSSYTSPTFETPNTNVQWCSIVKTNLGGFRMFLGGEVDCLRAGWTEADPIRTDDFVELKTNIVISSQRDEMMFERQKLLKHYTQSFLLGVPTIIVGFRTRTGHLTALQSFKTLEIPRLVRNKSHAWSPTTSLTSAFDLIQFIISTLSSDENNQAAEEEFKVNGKIPGQEWPVWRMRFRPLEEGRGGGGVLELVQLTGGVVEEEVLGGKKKEERVGFLLKRWVEGLGRRIGGTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIW3</accession>
    <name>A0A2X0MIW3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C011g06647 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C011g06647</name>
        <name evidence="2" type="ORF">BQ5605_C011G06647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIW3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY12896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="50" mass="5525" checksum="12B3D5F169837BD8" modified="2018-09-12" version="1">MKNVIQQKATERRGVKPKAEGHVPGCLDGKWNLDERGQNGLSPRGLSRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJ90</accession>
    <name>A0A2X0MJ90_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C037g11620 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C037g11620</name>
        <name evidence="5" type="ORF">BQ5605_C037G11620</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000062">
        <property type="protein sequence ID" value="SGY93985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJ90"/>
    <dbReference type="STRING" id="796604.A0A2X0MJ90"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06141">
        <property type="entry name" value="WRN_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051132">
        <property type="entry name" value="3-5_Exonuclease_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620">
        <property type="entry name" value="3-5 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620:SF104">
        <property type="entry name" value="EXONUCLEASE 3'-5' DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="4">
        <location>
            <begin position="460"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="174"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="360"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="657"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="663"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY93985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="796" mass="86322" checksum="E42259D032B80E07" modified="2018-09-12" version="1">MLRRTCRTSLPMKRTCPVSPRKGSTSRREPIDAVQSTATMFPTPLSAEGATSSAASTPDQGSLLPAWKPGQAIVFESSTSPSSSPSGCPSREFRSQQMIFTQKCPDHSASGIAHLSPHRPRTTFFPPSSFYRPLAHKWNASPVAAFPSSRVEKGDHLVGTRLAQHSPHSMCVSAITPSSEAGSSSARAPPSSSASSTYPASPAVVSQAEMDQLVEGIDFSDVEEESGTSFEVEISRLVQLTKRREEASRGQAKGKGKATDLEWDLAPRPRTLLGSLATSNRINIDPSTYRRVSPSRAYLISAHPSLDANEDKASRARSSSLAPEMSPERLESFMEFIDVSSDVSIESSLASDDSIQIVEPKTAKSPGPSAPAVAASATSTNTTATRHQRWFAKPDSIKQKESLASNAKLPPVNEAPTKLGPRAQKAAQHKRKVEADRSLREKHKTVFDFTCTGGRTKPNLIYTNSADEVAKVLKAMDDGPYGFDLEWEPSKRRGVENPTALAQVCDGQTILLVHIARMSTFPKALKEFIEDPTKVKLGVQIAGDARKLSRDFGHTPRGLLELNNVGKLVDGPRYAGRILIGLQEMTGTYLDMYLPKEGAVRCGKWSGTIGAEQQHYAANDVWASLLVFRFLESLAGPAHAIMSQVSHDMSTASSFRATPRSVTGTAKSTAATPKPPATARVSKLSPRQQQAYDLYRTLTLQETTDAMCQTNAIKMSSVLWNLLVVFDGSTTLTNKTDDGSSGEGAFFMHTEMKQKLWKDVSDAWGTSNERFKATHEAVVERLAAELNLPVPWSNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJZ8</accession>
    <name>A0A2X0MJZ8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C034g11248 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C034g11248</name>
        <name evidence="2" type="ORF">BQ5605_C034G11248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000065">
        <property type="protein sequence ID" value="SGY98848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJZ8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY98848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="112" mass="12137" checksum="5D6CDB96570F75CE" modified="2018-09-12" version="1">MSPVASKRSKKNASPPRDTNNSPQVYFTPQEKPAQAPEDDEDAMSVVEAHLEQQQEVPPLEPSDLSDLQDRGAEGNQGEHTETSDAEEGESQSAETGAVPEIVRRLLSIPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKH2</accession>
    <name>A0A2X0MKH2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">proteasome endopeptidase complex</fullName>
            <ecNumber evidence="3">3.4.25.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C031g10994</name>
        <name evidence="12" type="ORF">BQ5605_C031G10994</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="3"/>
    <dbReference type="EMBL" id="FQNC01000068">
        <property type="protein sequence ID" value="SGZ07126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MKH2"/>
    <dbReference type="STRING" id="796604.A0A2X0MKH2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03762">
        <property type="entry name" value="proteasome_beta_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000010">
        <property type="entry name" value="Proteasome subunit beta type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF0">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE SUBUNIT HSLV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="9" id="KW-0865">Zymogen</keyword>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGZ07126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="275" mass="29353" checksum="83CFB47450A51EAE" modified="2018-09-12" version="1">MAHTSMTTTLVPDVSHLKSGEVNLGTSIMACAFPGGVVIGADSRTTTGSYIANRVTDKLTYLHERIYCCRSGSAADTQAVADIVTAQLSQYAMQHEKRPTTAVAGAMLESICYSNKDSLSAGIIVAGWDKLTGGSVYNIPLGGGLFKGPWAIGGSGSAYIYGYCDATYREDWDKEQTVEFVRNALALAMARDGSSGGTIRMAVITEGGVERIFVPGDKLPGKFHSDGHVSREGRGGAWDAFWALLVAIEVGARAESALVLILWSISRFAVFWEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKP7</accession>
    <name>A0A2X0MKP7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C032g11039 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C032g11039</name>
        <name evidence="25" type="ORF">BQ5605_C032G11039</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000067">
        <property type="protein sequence ID" value="SGZ04026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="416"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="655"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="759"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="666"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGZ04026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1303" mass="142126" checksum="8AE29BA7E8B46EC7" modified="2018-09-12" version="1">MSNPAISTRHATCATREAGRNGSTTSKPNARTDLEHANFQAIALLRRSVSLNIKKQIKDGFDHTPTDVLKMIKKAVAAGTVTDIFIKLQALLDAGPPPSGVDVFEKYQANTIELFNTLSGYNLTFDQVISIRLIHFGKDLYKEYYTQALRQDLDKLPDPIEALQTLQTQAESTPAHKPVAMVASLTATDRSSSTPSAPCRHCGGPHWNRKCPVKDKKSKASSAPSASLAAAPDISTLVDGPVRGYLTAAMSTLAKPSLILNSGATHHIVNDRACFTNFRKCKPAPLEGITGEAVNSIEGVGSAVVRSFDGSIGQLHHALFVPSAPVSLFSASRANAAGYDINLSRGKATVSVDGSICHTGEITNGLYHMHASLVDVTTLIEQPVNMEVALNEDLKCDTCQAGKITHHPFPTVASNRSAQPLDRVHMDLLAFDGAVSLGGAKYALVIVDDYTRYLWAIPMSHKSDTFAAFKSWLAKVERSSSRKLLAVRSDNGGEFLSNEFSSFLEEQGITRQLSIPDTPQQNGVAERANRSITEGVRSMLHQSGLSHALWAEALATYVYVKNRSPHSANSGVTPHTRWHGSKPSAGHLRVFGCRAWKAATTEARSKLDPRGIPLVFVGYDLESKGYRLFDPATRQVFKSRSVTFFEDEFPARREGITAAPAPVAGNDDDDDDDDDEVVVLPDQHANQAPPDQAELPAALRFDAPGPAWQPPVGSRPRNPPARYGALASLRSTPSAFAFSLGKEVTELVADLEAAGIDTSTANRPLSEPEDPFSLPSSDPTTWNEAMRHPHAAAWKAGAIEEFRSMKDDLKVFSVVELSSVPKGATILPSRHVFRTKRDKAGKMVSLKNRIVAQGCAQGPNSFNNTFSPTAKYTSIRTLIAHSASKGHHIIQADVDKAYLHGVLEEEIYMRVPTGIEGYEGKCLRLHRSIYGLKQAGRVWNNTINATLASLGYRRLACDECIYCHEDAGGDHYIALYVDDLLFFGPDLGEIDRVLDQLDTLYGVKRLGPAEWVLGVQVVRHDDGGISLLQRQYLLDVLARFNMSDCNPCKSPMEANLQLSPEPDTDSANNAIYRSMIGSLMYAVVATRPDLAHSVGYLSRFVGKAGDTHLEAAKRVLRYIKGSLDLGIHYTRTSAPLLGYEGYSDSDWGSDIQTSRSTMGYLFKLAGGAISWSSRLQPRVACSSTEAEYLGLSHAAKEAVFLRSLLTELGLDTSSPLRLLGDNQGAIALTQNPVFHARTKHLRMLEHFVREHVRNGEISVTYIPTHDMVADIFTKPLPRVVFQRHCDAIGLRRISGQEQGGVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKY2</accession>
    <name>A0A2X0MKY2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C022g09531 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C022g09531</name>
        <name evidence="1" type="ORF">BQ5605_C022G09531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MKY2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ22714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="57" mass="6342" checksum="9D58B4FCC04070DB" modified="2018-09-12" version="1">MPGSARRGEQWYTIPLPSSRAKKQKSCLIARARTSSFAWLNGPADLPWRPWDLGTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MM00</accession>
    <name>A0A2X0MM00_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein transport protein SEC31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein transport protein sec31</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">BQ5605_C003g01877</name>
        <name evidence="15" type="ORF">BQ5605_C003G01877</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SEC31 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY37732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MM00"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040251">
        <property type="entry name" value="SEC31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923">
        <property type="entry name" value="SEC31-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923:SF11">
        <property type="entry name" value="SECRETORY 31, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="7 13" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="163"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="320"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="591"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1040"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="617"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1040"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1059"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1140"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1173"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1189"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="1253"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="1282"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="1311"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="1369"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="1398"/>
            <end position="1443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SGY37732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1554" mass="162123" checksum="4BC7F7189C42D1C7" modified="2018-09-12" version="1">MVTSIARTAVPIWSPQQLRRATPLLATGTVSGALDASFSSDSLLELWDPFAATASSSLPQVEGLDLGNQNQNSALDQTELSTPLASLAVGSRFNRLAWGYIKQPDKALGVIAAGLENGEIGLWDPSRLIDKTRGEEEWREAGTHTHTPGARRLNVGGASLARYDLHKGPVRGLDFNQHQTNLLASGATNGEIFIWDLTTPSKPFSPGARSRSLDDITALAWNSHVVHVLATGSNSGYTVVWDLKSKREVTALSYSGAAPTGVGSAFGQPGWGAPGGSRGVSAVQWHPTNPTKLATATDDDHNPIIMLWDLRNWKEPERILTGHEKGILSLDWCSQDADLLLSSGKDGRTLAWNPSTSEIVAEVTPSSNWSFDTQWCPRNPSFISTASLDGKITLQSIQSTAAPTAAADAAATSMGAGGDGTNMFEAAISANAANYPTKSLAHAPKWLRRPASVAFGFGGKLVSISHTAAPAGAAPGTPATPSVSIRNVVVQPEVVKRAVRLDEAQSNGTLAQFCEQRSAEIEQSVDIDPKSKEGEVSSWKLLASLFGAQSKGGLIDLLGFDRSDHKAKVDEAVKALKEKLPASALAISSLGSNPEGVNGVQETADGAIPLGSELDDSTATSNSLASEGTKQSSETTEPSLFDGADDGASLNAGSSQAAADFYSQIGSGRAALPDHLFSNGNGNRENFSSAAATAGSASSVASLNLRATTFKIYREDESEVDRFITKALVLGDFASAVALALSNDRFADAILFAVRGGDELLATTQNIYFERQQAAGAPYLRVLQSIVGNDLADVVQNAHLAQWKEIFVVLCTYANADEFPSLCEQLGQRLEYQYDTVKDSSPSTAATELRKNAILCYLAAGKLEKVVGIWVQQMEEDEQASRAQNGAHGGAQRYEAHAKALSAFVEKVSVFQQAVDYVDTDLHVQSAEPGRKVYKLAELYERYVEYAELLAAQGLSHIALKYILQVPHDFQGSTDANGPSLTRDRLLRASGNQSAGGAFGSSQRIVAGAAPVASTSYGASNNAYGTSSYSNYGQPAYAQQQSSGYAPAQSSYGAPPPQNNAYGTSQRSAYAPAGGSTSSYNNALDDPYGSGGGHPTNAYGAPSQPFNPYGQPQPAAPMSDPYAPQQGSGFVPPTPALREQSPNFAATAVSSIAPPPRSKPDVGWNDAPQVQRKATPAAATSAAPPPKAAPITSPFPNMSPAQGAGGRPPPAFGGAAGAGGFVVPPPPPSRGSNRTPAPVPPPPQVGQRFANAPPVPQPTAAPSQYAPPPPQTLQPQQQASPSPSPYAPPPAPQGQRFAPPPPPQGGAGARPAPPAGFPAPPAGFPAPPAGYRGPPPNDGEFRPSSAAGRGRPFPPGQGPRGPTPNGNGPAPPNPYAPPPSGQPPSGPYAPPAGAQNGPPRPGGFPGPPQGYQPQGGPAPPPPSQTPTPAPPPGRPGPPKPKYPPGDTTHIPAESKPIYTCLNAQLTGMRNLPPGPPQQRKIVEDTAKRLSMLFDALNCETLSVATRDRLLEICRAIDAKNKAQALDLHLQMLTSGANDLAAWQAAVKLIISRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MME9</accession>
    <name>A0A2X0MME9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C020g09168 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C020g09168</name>
        <name evidence="2" type="ORF">BQ5605_C020G09168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000082">
        <property type="protein sequence ID" value="SGZ18160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MME9"/>
    <dbReference type="STRING" id="796604.A0A2X0MME9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051150">
        <property type="entry name" value="SWT21/TCAB1_mRNA_Telomere"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211:SF0">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ18160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="403" mass="43469" checksum="1AC062F54171EFA5" modified="2018-09-12" version="1">MTEPEYRQAPTLARSAAAAPVSSRRLQQSSSAFFRNAIISSDGSCALVAADDRSLSLYMMSVTVTTSARSNHIAPTSTSAAPWTPVWHYTPPDALLSFQWFPHASPSNPPYFAFVVAVKDHPVQLLDGADHRLRATYAIIDHQERFVAPHSMVFTPDGSHLICGYDNALEIFDVSLPGAEGIRIPTSPTKKSRSGQKGIISSLTISPDATLVAAGSFSGSVGLYDLTLDAKLIKVIRTNERGGVTQVLFHPSGHLLYVASRLSRSIEVIDMRNLNKPLGRYPRRARTNQRLGIDVDPSGTWLAAGDVTGKISFYSAEFDPLNATPFYSLKAAQEPIGSCHYVPGTKQLMTCSGSRKFQVMGSGDTSSGSDSESDGEGDGDRPETETASKPTARGDSLQLWDQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MMY5</accession>
    <name>A0A2X0MMY5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C020g09106 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C020g09106</name>
        <name evidence="2" type="ORF">BQ5605_C020G09106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000082">
        <property type="protein sequence ID" value="SGZ17251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MMY5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ17251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="321" mass="35538" checksum="C4CFD1AF3E5609ED" modified="2018-09-12" version="1">MCIRDVIDRPRHGRYQIPSPSSSVSNSTPPTMCDLDPVVAALEGGTDDMEEYALFKGDIVPHLLLRSAPELVEQVFGIDHPAFDEISQRARQSGGQVQSGQAQDIQAELRKRFQEAHDGSQNPRIEPSTSQLAWMQEVARLAQTDPTHGIQFKLAVATAERPARLYIHDTIRRCFDSSPESDKEAKEWTPFLTCCKVETSSKRLLWNRVLVPCAFDASPQRSQFPGGPGAFAPELVKVVLDLTEHVLSQPTRLFAPGLAVSDRKAYLVVLDQETCRVATISDCWGQGFGELAAVLSILLDLNFYSAGFCPVFELVNRRASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MN06</accession>
    <name>A0A2X0MN06_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C020g09126 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C020g09126</name>
        <name evidence="8" type="ORF">BQ5605_C020G09126</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000082">
        <property type="protein sequence ID" value="SGZ17518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MN06"/>
    <dbReference type="STRING" id="796604.A0A2X0MN06"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015948684" evidence="6">
        <location>
            <begin position="30"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="7">
        <location>
            <begin position="161"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="498"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="544"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="594"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="611"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="660"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="697"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="718"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="790"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="812"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGZ17518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="865" mass="91307" checksum="B61E358C781826F6" modified="2018-09-12" version="1">MRTVDPGKSSMGRLCLLGLLSLQSTLTSATTHEPSGATGPAVVTLKIAQTHSNHHFKNEDGTVNTTRFNSHREHLEAKYFSNYQIATSTKKVTPFFPHTANPLQKRVVSADLKTTLEIAQKIEANFEAKRKTNAKLDKRAGGTGASRVALGGFDWGPGVVHQVGTGIGTPSKTFSLTLDSGSGLSWVRSECKDNDEQQCAPGRSRLSLGNSSTLMKSSTNWSTSYASGETSGLFMKDVFQIGSLQYKDQIFASASKISQVLNLVPTDGILGASFSTIAMGQVPTILENLIMSELVEQPVMSFTMNRGTSPQYGSLTIGGIDMNVIEFRTLRFYQVLTLGYWQFKAAGLTVGGKVVPGTAMECAVDTGSALLFIPSAVADAFFTTVPDARKSENLGWTVLCESLATIGTIGIAISNVSYSIPILKLVIGTDLYDSSRCKLAISSGSNIDINGNPVAIIGTVFLQHVYTVLSYSNNKQPAVGFASFFGSELVIDSVDGAALSPASDPSPPPSDKDVKPKPIALSTPDPDTKLPVNKTQTPVPPTTQTPVTPTTQTPVHGPSKDAGKSNPHPVGESGGEPTPESDPKKGSSPNLPETTRHAAKKVEPPQITEAVRQDPKEKGATKPNVKVVETPVPDVKGTKQHDAGGKSTPVAKKQPGAKDIGPKEGRPERTPTPSDFHAPEESDSTKNTTAKNPAPKSKTEEEPAPKSKTTEPAPKSKTQKEPAPKSKTEKAAAEKSQHPEEHKSAASDKTPEGKGTKTEHDQAAGGKDQDGKALPPVDQRADFGPPTVQKVPSLNTSSNGSDSQPGAPGGTNIPNPILLSNSTLPPDTFKPAQDPHSAAPAILSSVWSSSAVLVLVSARFLLFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MN55</accession>
    <name>A0A2X0MN55_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C015g08014 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C015g08014</name>
        <name evidence="6" type="ORF">BQ5605_C015G08014</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY18233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MN55"/>
    <dbReference type="STRING" id="796604.A0A2X0MN55"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025784">
        <property type="entry name" value="EFM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF10">
        <property type="entry name" value="PROTEIN N-TERMINAL AND LYSINE N-METHYLTRANSFERASE EFM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51560">
        <property type="entry name" value="SAM_MT_NNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY18233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="348" mass="37535" checksum="05F5E84C29FA24D3" modified="2018-09-12" version="1">MSAHRSASPARSDASGSSSADFAFDFMQGKVQAYRAQPESFRPKTPPPTTASYTRRALGGHGPLQAPEEVQVRLVGGHPLWGHLLYPAAIALARYLETHAPSLLHSSPNDSISDPKGKRKVEPKRIIELGAGGGLPALIAALESDPSTKVIISDYPDQDLVDNLQYNIALNGFREDKIQAKGFAWGHSVAPLINGVWGDEQGEGEEKFDVVLLSDVVFNHSQHGALLESCKALLKSAPPKFGRLSASSTSSLPVRPIDLTPPELDLHSPLVLCFFSHHRPTDILIKADNGLMELAKTKGWIVTKVWEDPHAGPAFPEDKGDLAIRSTVHGYAFTRPSPSPTATSTREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNX1</accession>
    <name>A0A2X0MNX1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C003g02467 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C003g02467</name>
        <name evidence="8" type="ORF">BQ5605_C003G02467</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY41081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MNX1"/>
    <dbReference type="STRING" id="796604.A0A2X0MNX1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000001">
        <property type="entry name" value="zinc finger CCCH domain-containing protein 15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="CCCH ZINC FINGER/TIS11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547:SF18">
        <property type="entry name" value="PROTEIN TIS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="555"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="593"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="555"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="593"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="42"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="291"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="408"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="626"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="718"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="631"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="653"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="771"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="785"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY41081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="910" mass="97762" checksum="CE2CF6BE90E28637" modified="2018-09-12" version="1">MLPSLHPHLCALEPVPGPTSPQSCIRAEQHLPAEATEAFVAAKDVKASAEETNEPQREGCTPTGLDRSPQLVDESGSDDHKPQPLENDDLDLSLASIPSLDYLSLDDDDDDDDDGDPHGDHRSGLSSTSSCRANVTLFSPSLASSDEFAHSNDSPFGLTHSRLAPTARPFVFVPKAHRSEADGAAKEQAPRDRAALLPTAPVASTIPGAFEPKQSRQSLAPLNVDLSTHPLTPQFADLRSKADLDGVEQWRKLTAADPKASTWSFDEVGHLTSEGARYNIADEILRLQSQADQESSTLEQAADMTCHSPSHKLQSGHWPNETVWPEPSSSNSLDRPAAFPTFPRGLSPISSNSDASSRRPHNSSPDDGLSNLPRPIRTRNSSLESSKYAYIKPGVFREASTYVSHPDSEFERLRGESHGPGGAMQPLVSPESTPAPLPTRARARSMLASSSELAMHDALYLETRNTFIRQALINKGLPATLANQEAMISLFDQAMRSDSPLSLLADLNEPPCVSSFEPFSEHRRASVDVVASHSARAPLNDGLGGPHSGNRKHGLYKTELCRGWEEKGSCRYGSKCQFAHGVEDLRYLNRHPKFKSEVCRTFWLHGSCPYGRRCCFIHTTVPPESSLHKQSSATSPASCPSPSESFHGNDSTISDRRDSSKQEARTGNSVPSIASLGFGPALSSYLAPSVTTSVPLPTPNIKHVDHDADAMWSELGHDSTGVSSLGSRLGGHSKHSSEPISSVGLGLRTPNPSEVPPTFQSPPRSRLQRLASFPSSAFSSVARTQSDDFPGRPTEHPARSNGYSPSKDLLHSRQGSISSVASFNSSCSGSSSTSFASLAQNRSLRNASLSRTKSFGSLDLFPQEVNGLSLQRVGSSWLGGAGLSTKVRMLSSNGATGDGHVQARALDWDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPA6</accession>
    <name>A0A2X0MPA6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C017g08361 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C017g08361</name>
        <name evidence="1" type="ORF">BQ5605_C017G08361</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY19873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MPA6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY19873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="61" mass="6558" checksum="7CE5D025A7555E5D" modified="2018-09-12" version="1">MPSPEAAARNRSTQRRANWFVKSTAPAAGSLNVARQVQRARSSSPLSLSFVRPLVPVPDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPE7</accession>
    <name>A0A2X0MPE7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C023g09650 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C023g09650</name>
        <name evidence="2" type="ORF">BQ5605_C023G09650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ23866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MPE7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="696"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="744"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1047"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1162"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1226"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1386"/>
            <end position="1517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="292"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="563"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="584"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="696"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="744"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1170"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1227"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1240"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1340"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1409"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1436"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1481"/>
            <end position="1493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ23866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1517" mass="160101" checksum="C254C0D54377667C" modified="2018-09-12" version="1">MDSQAQRRPQARRAAPSRRAARIPNELELEREPPPLPVPPPPPPPLPSPNYNHNHEPGPSSSPRPASSTALSPSSRSTSFVSLPSPPSTAMLVTIVLLVSTGAVLYVSLQSRLRYPAATRPSTKTGRRKQQNLVKAVAAAQQATRTKSVTTTSQATSASSDIGAGPHMSASNSTTTTTTATTDDLGGGGPTRNQSGDEARISDSEATTEGWIPACVAAVFVLITSSLPWSRIPRVSTPFPVDQIAPSPPQVTNARSEDVGAADRSSLSPLKQRPSQGLPGRKSSNRKGKGGLTLASLSGLTALSPGPSPHRSTFPSVPPTSASEDADTITTPREGKSDGPTPPIITIAASSPKDLEEAGSSSTRGRWPTTRPVLCDASVQTSPILGAIPAEGSVLPNLEDLDVMSEGTSLQLFAPNGLNLHTSFEHTLQLGQRQFGPAPNSDRSSSPIDATVASRTDSINFGTAPPSPSTAPTTPATTHSQLRRPRNGAPRSIALESTGTTDYSGSSQGPESSNGAGSAPLSPVHAGPALLTVLDLDARWSRGRDGTSQVSLPGSHKHSINGHTDSTHTTTSFSPNDRRPPPLSRSMSSPSTPSSETRRAAGGSKSSSHRKSPSVVNGAGRQLRLDDPYWKTGQTGQMDLAIDGSSAGMATRGPLFRLPSEIVHHDSPKLAREDAGGGLGGYCGPNTTTNRLDYASSSEWASPHSSPAPKRSQLSRSAQQNASASEYWEAADGRWPQNVIASGLASSGGQASAPPGQNQHFGSNGGATQLETQAAASRHPAGSFGFSPITPSQATTSFYPPGYHLIADHNNYGVAVHPSPLSSPSMLQSMAQQQQQQQMHQQIQQQMQQQMQQLHAQQTFQQAQAQAQHVLALEAQVHQLSLRHQQLSQIERARLEAEQHQQHRSILLAQAMVDGSLCQTASTTSNTASADQMHAPTLHSGAAAAAATPKPPVDALVYPISSSSNGSDWTPPLIGSATSTAFPSSSLLLSPTSTFPSTSVGAYPASLSAAPAFSNGLAYTMPHLFNAQTVASMSVLSASIQHQQLRSVLPPPSIPQRPNNQRRMSAGRNGNDRNRSTSNAAALSAFAFSNTDRSSLEWQEAFKSKVKAVEMDAERTAKELEIARWRLIVLEEEQHNLEVENQEALRALANRAMRAEARLKAIDNSRHEASSTSESGSPKAQASSLTVTEIGISASRRKYSAEHMGDSQTHPLSYIDLDSVSFGVTPLPSTHSSRPPLSNECRRSSRRTSDPSLPGKQQRRSSQNSRRRSTTTFPNTHQADAAAAADPNDDDDLVIVLDTPTRSHRLVSRPDQASYPTALASSSSKGGAESYREGESLTLIDEDQVSSIDADDFGGPRTRASSIVETISGPGYIGSLPTFLSPRWAPPGGTLSLTPNPGGSGKESPNLGSSSDSSFDISPRCRIEALPEEPSPPQLDHQQSTTNSSPPLCTQDASDIRPSKLNVPDGAVKDQTIGQLAHPRAFIERHDSSERTPRVGAGDPAFSAVPDAIVEDRPTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPG8</accession>
    <name>A0A2X0MPG8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C017g08431 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C017g08431</name>
        <name evidence="2" type="ORF">BQ5605_C017G08431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY20006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MPG8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY20006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="133" mass="14557" checksum="FCB7ABE15188CDE7" modified="2018-09-12" version="1">MKLNLYPLTFALLAQPLPLPSIADVALISIRRLGRLHIGSIRSPASTFVSHTLFQHCHRPHPSRSSVHAFLANNVCVIVVIVIVGIVIVGVVIVVVVGYQVTGWQVTGDGRTRTAQQLRERMVGCNTPTAWFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPX7</accession>
    <name>A0A2X0MPX7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C001g00172 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C001g00172</name>
        <name evidence="5" type="ORF">BQ5605_C001G00172</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY44553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MPX7"/>
    <dbReference type="STRING" id="796604.A0A2X0MPX7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="36"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY44553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="331" mass="36531" checksum="66DD9CC7AA41392F" modified="2018-09-12" version="1">MPTHASACLHSPKATMVNTIPIPSIKLNTGPSIPAIGLGTWQSQPGEVAAAVETALKNGYRHIDGAWIWLMDRNFALADGNEQEVGEGIKASGVDRSEIFITIKLWCTHQRDAAAAIEKSLKLLGVDYVDLYLIHWPVPMSPNGNDPKFPKKEDGSRDLDLEKWSVAKTWEGMEKVYKSGKAKAIGISNFSEAFIEDLLKTAKVVPAANQIELHPYLPQHDLVKYCQGKNIAVEAYSPLGSTDSPLLKDEEIVKIAEAHGVSVGTILISYQVARNVVVLPKSVIPKRIIDNFQLVKLSSEDLETLNSMHKTKGKRFIKPDWGIDLKFANWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPX8</accession>
    <name>A0A2X0MPX8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C047g12307 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C047g12307</name>
        <name evidence="7" type="ORF">BQ5605_C047G12307</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000113">
        <property type="protein sequence ID" value="SGZ31111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MPX8"/>
    <dbReference type="STRING" id="796604.A0A2X0MPX8"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003923">
        <property type="term" value="F:GPI-anchor transamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000016">
        <property type="entry name" value="GPI-anchor transamidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028361">
        <property type="entry name" value="GPI_transamidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067:SF1">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500138">
        <property type="entry name" value="GPI8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027685806" evidence="6">
        <location>
            <begin position="24"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR019663-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGZ31111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="403" mass="44963" checksum="A9FDC44D3C628E18" modified="2018-09-12" version="1">MLQPRQLLLLLALLLSHLVLLHAAPSTNNWAVLVCSSRFWFNYRHMANTLAMYRTVKRLGIPDSQIILMLADDVACNPRNPFAGTVYSNADRRYDLYGTSIEVDYKGEEVSVETFLRLLSGRFSESTPVNKRLLTDERSNIFIYMTGHGGDEFLKFQDSEEISAFDLADALGAMWEKKRSVGCWFKLDEGPRYHEILFMVDTCQANTLYTKFYSPNIIATGSSAKGENSYSHHADNDIGVAVTDRYTHHVLNYLEGINKTSNATLQDLFDTFSFEKFDSNAGIRTDLYPRPVSQVLLTDFFGGVAQVEISTEEEFDSSIELNDIIDDSNSENEVVPVPLPSIPPRRRLSTSITSTGSEKAYKGETIRPCSVLAVVLVLVGLQVLASKFGQASGDTEGVKTKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQ41</accession>
    <name>A0A2X0MQ41_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C047g12324 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C047g12324</name>
        <name evidence="2" type="ORF">BQ5605_C047G12324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000113">
        <property type="protein sequence ID" value="SGZ31169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQ41"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ31169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="221" mass="24745" checksum="1994D147E5DCAE12" modified="2018-09-12" version="1">MRLSWYHAIGQLHPPQIPSSSCQPHHQPLAAVVPESDDSDSELALPRKYARIHAANTATHRKKPTNERLHGKIGATRMVRVSPALQRYLEEADLQRDRRVEAIEVPHTHKWGSEADMVPLVKAIMGVASESTDRAFVVCGRSNDTVPTAQGQVPSDDHCADIVCLYPHATTPETIEEWLRTDLERLIGEKASSISSQQARRPTPRRRRRRWGAQGIRAPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQL7</accession>
    <name>A0A2X0MQL7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C024g09883</name>
        <name evidence="8" type="ORF">BQ5605_C024G09883</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ26305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQL7"/>
    <dbReference type="STRING" id="796604.A0A2X0MQL7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06565">
        <property type="entry name" value="GH20_GcnA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.670">
        <property type="entry name" value="N-acetyl-b-d-glucoasminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041063">
        <property type="entry name" value="Glyco_H_20C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038901">
        <property type="entry name" value="HEXDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21040">
        <property type="entry name" value="BCDNA.GH04120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21040:SF8">
        <property type="entry name" value="BCDNA.GH04120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18088">
        <property type="entry name" value="Glyco_H_20C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="6">
        <location>
            <begin position="211"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside Hydrolase 20C C-terminal" evidence="7">
        <location>
            <begin position="548"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="156"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGZ26305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="776" mass="87388" checksum="83840E0D277A6132" modified="2018-09-12" version="1">MASELLIASLTSTMPNPVSVRPSIGARTASARSLPKSTHPRITIVLPSARIPDEIRPGVIELAKHSVRGNVSVLDDDEAAPSSDGSLYVWTVGWVNFWHDPSIGDRGMRLDCNLDDFTATGGAFEIEISYNRTVEAFRGLGHVLAISRGLSTFDQPLSSSADSDPDRMSQSDAGSGMKDVHEGHQSDGVRWSGNVGSDIRRRETCLFESVGVMIDCSRNGVLKADAVKWLLRHLALMGVNVLQLYCEDTYEIDGEPFFGYFRGPYTEAELREIDNYAFVLGIEVIACIQTLGHLGQMLQWPKYGKLRDTAEVLLAESGETYTFIEKMIQAVTRPLRSKRVHIGMDEAHGVSEGRYRQLFGYKESTTVFTDHLQKVNSICVANGLAPMIWSDMLFCLPAKNNALSGYYDLNTVVSEELTSSIPAEISTVFWDYYHTDSRPYTAKIAQHWQLVNKAPWMASGVWTWSRFWTALPFTFATVRASMKASKNPTAGVTAVMTTIWGDEGNECDLYSALPGMLYQAEHAYTQAEEVDAGLLRKKFDGIAGADFDDYVFASKLDDTQPETQPISINTHYTPNIAKFLLWEDPFFSFLSPQYRGYDLESHYLHVATYLEQALSSDFSAMTTIAVPHSVDDFPANKRLQLPYLLARILSLKCHLRERLVHAYRHADHVEFTALAGPAKESRLSRLRALVKELKKVHRRHWFSLYKPFGWEVLDLRYGGLEARLETMHERLIAYLDPRDSSVTRIEELEVENEVVFEGQRLNLMLDYSRASRPQYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MRP3</accession>
    <name>A0A2X0MRP3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C040g11840 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">BQ5605_C064g12781 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C064g12781</name>
        <name evidence="4" type="synonym">BQ5605_C040g11840</name>
        <name evidence="4" type="ORF">BQ5605_C040G11840</name>
        <name evidence="5" type="ORF">BQ5605_C064G12781</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000118">
        <property type="protein sequence ID" value="SGZ32270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000132">
        <property type="protein sequence ID" value="SGZ35130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MRP3"/>
    <dbReference type="STRING" id="796604.A0A2X0MRP3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016150">
        <property type="term" value="F:translation release factor activity, codon nonspecific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070126">
        <property type="term" value="P:mitochondrial translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052104">
        <property type="entry name" value="Mito_Release_Factor_mL62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11075:SF54">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11075">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="3">
        <location>
            <begin position="63"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="153"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="159"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ32270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGZ35130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="196" mass="21971" checksum="22615C4B5CA890A7" modified="2018-09-12" version="1">MAWCSRPLDPMADGVDLLSSASWQQRPELSWGAPLLPLDRTRHDPRTRMDLPFLLRATLRLPQSFSRSSGPGGQNVNKLSTKAHFRLCLSPPPPWLPSYLLPTLLDSPSYVSTTPPGLLLSSSNTRSQAQNVELGIKRMKDLILEAARVGLKGDTSEEQQERVKALERKERSKMLKVKKQRKDVKGGRRAFKAGFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MS16</accession>
    <name>A0A2X0MS16_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C027g10416 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C027g10416</name>
        <name evidence="4" type="ORF">BQ5605_C027G10416</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MS16"/>
    <dbReference type="STRING" id="796604.A0A2X0MS16"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="130"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ28702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="401" mass="43871" checksum="C82673A60B0C844E" modified="2018-09-12" version="1">MNLVDTFAAPFLLGTFLNVFLAGINWMQIITYFNTSRSEENAIYKWVVGIVGLIGTWHTCFNVVGVYNNLVQNYDKLMNLLSIHWSYVLDPVTTAVVAAISTPARNLQTFYAYRIYILSKRSIFIPLLILFLTLSDFTGTNSIIDKVIRYTVTNNGLTAAAAICSSIMFQASSGLWHVLPGTIIIKLYSISLMASLNSHKNLAHDLALSRTGGRGATKLARGGSPKQLLHFPGVNGANQVASFSCQNVQSDVRNPPSLHFKDTPLRHVAKLIGVGALGNGSLGGSASRSTSMRSMSRRRGGSDHHGENSFPVQVTIDTTSTEFQVEQMDWEEKERKKVFKSEEDRTNGDTGSAKASSIPIALPVPTLELTNPPFRIYVEEPDYASSGLEIGTSQSDLLSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-10-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MSC9</accession>
    <name>A0A2X0MSC9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C048g12381 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C048g12381</name>
        <name evidence="1" type="ORF">BQ5605_C048G12381</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000110">
        <property type="protein sequence ID" value="SGZ30488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MSC9"/>
    <dbReference type="STRING" id="796604.A0A2X0MSC9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051288">
        <property type="entry name" value="Serum_paraoxonase/arylesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799">
        <property type="entry name" value="PARAOXONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799:SF12">
        <property type="entry name" value="PARAOXONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ30488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="393" mass="44034" checksum="F03E26BD0CBF3529" modified="2018-09-12" version="1">MKTRTVLFVMLPGLLLISSFIWPIVQVIGLTRPVNQLHNTKCQRVPDLPAVEDAWIDYDADEAYLCGSSQESRQHWLPAILHLNASKLPEHSVDYVAVMDLNTLKHRRLEIVAPTEVTKDFNTHAIEGFHRASDRKHLTLFLNSHRPPAEGRDLAPKLGADSVIEVFETRTGSNQLKWLKTIRHPLIRTPNNIVATSETSFYATNDHRHKVHWGRAFGIFYHVRSDIIHCDFASGETKCIVAAEGVYNPNGIAMGAQNKLWQASSGEPVLTVYEIQSGDHTLIPTDRIPVGRIMDNLHVADDGSVYVNTFPHPLHWVKAAATAGRNKHLAPTEAWRISNNTDESRHLGKKYKVELAFADDGSNVMWPTSAVPWKNKLISTGIFSETVVVCDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MWG4</accession>
    <name>A0A2X0MWG4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g02569 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g02569</name>
        <name evidence="2" type="ORF">BQ5605_C003G02569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY41829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MWG4"/>
    <dbReference type="STRING" id="796604.A0A2X0MWG4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY41829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="327" mass="36125" checksum="140D9F4FE9B5ADA0" modified="2018-09-12" version="1">MTVSDQDEIVKAVATANFCTKIDLQGASQRIRIKDEDVKKTAFSTPNGILYLLVAQQGDRNSTATLHRLVSFAFVRLYNRKIKHYADDLWPISNTKKIRLGESSMQPEKAAGIRATPAPKNKKDLQRFLGAVGYNHRSTPHLAELAAPLDALTGVNSPWRWSRACSDAFETIKAAFDDSAKLTCICSDELAPDGTFPVPLDPPPAEGEKVLENESKGNTGTNWWTAIPTGYHSRKFSPSRFITTPRTKSSRACTKDLNASKHSCEDVHSSSSRTARLAKFTTLPTLSRKQTRMYLYVSEFAYTAEHTTGRANAMPDILSRAPCDAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MY23</accession>
    <name>A0A2X0MY23_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C005g03534 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C005g03534</name>
        <name evidence="2" type="ORF">BQ5605_C005G03534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY76955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MY23"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY76955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="238" mass="26979" checksum="D5854E01BE32FB1F" modified="2018-09-12" version="1">MSQALPPLAPPHQPQSIAPNELDAVRLKLVQLIDSIQLLLSQVHYLSSTVPSPSTQHPGLLSYNEVISRYNLILSHVAALGGLLSSVGNPREAERRYRSGEPKRDPKAERWKGSLVVPAVSVEPAKDWVVGTLLRTKQTVEVENYLSELEESLPRVFKEEASRKRAMEEREKLVEGASERILSLKDGESGEEWDWRARVEFDEDDEESEKMQIEDDTEKRKWTVQEVATYQRTGKLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MYH6</accession>
    <name>A0A2X0MYH6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C001g00644 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C001g00644</name>
        <name evidence="3" type="ORF">BQ5605_C001G00644</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY48353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MYH6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040201">
        <property type="entry name" value="Mrg3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28142">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE I-AAA PROTEASE SUPERCOMPLEX SUBUNIT MGR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28142:SF1">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE I-AAA PROTEASE SUPERCOMPLEX SUBUNIT MGR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY48353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="470" mass="50696" checksum="7569DF9F426B0378" modified="2018-09-12" version="1">MTLTVVRRAVGAAARSVGKQPLPAPTLRSGHFVVLREASTTRSSTSSTSQRFYPRPPGTPGQSKGVKIGYVFGVLAFVGIGATSYGLYNFYSSFTAYPAAIRTHLRAALRSAATESYSRADASFAQAYQLALDDPTLGKTRQERLIKTTGIAIRWGAMWEAARELGKAIEVYDKGFREIADLVDAALPAQLASTSTSTTTATTDMPTKLEIMRGAAIALKVGDLSCDLGGTEALVHAEERYAWALQELMRVNMTPAQLQQVDIEQRHGSPDHRVDPPPIEGSEGDNDLPTWASKVELVGAMERLGGLYARQGKLEYAQPLLQQAIATLLPPPSKDANPRKKLPAPPVADRCHAATLMNNLASAFVQEPSPSVASIDSASRWARQSLAVAHGVRTEMIGKRGGNEVAAKDREEVECELVALVGAYNLGKLAELAKDKDSARKWFEKSRAQAVRIGSRDGLEQSLEAIRRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MZR6</accession>
    <name>A0A2X0MZR6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g03940 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g03940</name>
        <name evidence="2" type="ORF">BQ5605_C006G03940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY54966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MZR6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY54966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="382" mass="41565" checksum="708185AD90118F98" modified="2018-09-12" version="1">MQRTPRCFALASAATTRSLVSLQRPFSSVPPLQSKASKSRSKKTKLLVRQPTAVKIAVAPGSVAGLSNKGKASTAPRGLLEEEEEPSQPIHRAPEVFTKSSVNGASAKEVISDHLEVVDAKQSTVSSSHDKLHQSQEEEGTIYTSPPPFNVPLLMSACFAFSVFSLSGADIARRGYASYDEDKEAYELASPWKRYTFAGGFVCVSVGLVLWGTLAPGRVITKLTIRRGPTTATPKSSTPLATRYPPTSLVSIYTPLTRLPIMGGRPRQVELHRFVLLGPLAQGPKSWHPTHHSPIGTAQNKRHNPVSRALANLSDLLIAPSKPTSPSDRWKNKGTLSHVPLLVQGDRFSYTLGKRRAGKQGDLARAWCEDWEGFEKALLDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N199</accession>
    <name>A0A2X0N199_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C131g13368 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C131g13368</name>
        <name evidence="1" type="ORF">BQ5605_C131G13368</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000059">
        <property type="protein sequence ID" value="SGY89243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N199"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY89243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="260" mass="29194" checksum="A7D62BA51211DBD7" modified="2018-09-12" version="1">MICSFLMPQLEAKSSEDSFKIDDLVDPTLVKDMDKYTRIQVLGLYGRAKFTNMGESEVSEKDWTLLEEPRANRSLLGDLYRNRVLGKTAKTLAQRTDIYFRLSRCTRTVTDILLGLHSMAESQDLTHYAMLCNMRAWPPSADRSFKFTKETYQVEWCGASQADIAGPSSRPYNALPARIRGMGEAALLKALESMSSEEAVGFCKIAHPTHGFPVADQNDNVKVSVHLSCTGRSVAAMCLPPARKCDWGTSYFRRAWDKCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N415</accession>
    <name>A0A2X0N415_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="5">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C030g10791</name>
        <name evidence="11" type="ORF">BQ5605_C030G10791</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="5"/>
    <dbReference type="EMBL" id="FQNC01000069">
        <property type="protein sequence ID" value="SGZ08372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003840">
        <property type="entry name" value="DNA_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF95">
        <property type="entry name" value="HELITRON HELICASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02689">
        <property type="entry name" value="Herpes_Helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="9">
        <location>
            <begin position="387"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="8">
        <location>
            <begin position="1063"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="10">
        <location>
            <begin position="1362"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication helicase" evidence="7">
        <location>
            <begin position="1436"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="339"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGZ08372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1526" mass="171438" checksum="3D4B00E7C1B1B57B" modified="2018-09-12" version="1">MTTSQPILALRHVYEPAASAPGSNRAQTPQAHVSIRDDLGPQTAVCTHCKARHWECERSKSTRHFSACCSQGKVRLPPPPQPNLEYRQLLQGSDSEAVAFRENARSYNNALSFTSLAAHCWDQTQVDTLGPPVFRVFGRLYHRLGALIPAVNQRPAFAQTWLIDPAEATDTRLQGPDSAETRIQRSTLTKLESMLRTGNRFVREFASAKARAGWDTAKEWVLRLCLPPGRDRRTHNLSTSSTEMAMLICDSDTNTGDRGPQDLILQVHGDRCSDGRPKYQIVSSLHPSAMPLRYPLLFPAGEDGFHPNIPLCGFNQAGPPIARNREQIDNGVQLRELLDGLGPDEEDEEEDDEDEGDEEDEENGDGERRRSNKRGRGGSTRVSRSQYFAYHLHERDDYFSIPHVTQRLFLEFVIDGYSQVETDRLNYIRLHQESLRLTTAQGITDAVANGLTPDQIGRSVILGSTFKNSPREITQHYQDAMACVVKYGKPSLFITVTCNPEWPEIKAALGPNDKACNRPDLIARVFEAKLNRLCDDVFGNKQRAGCFGVVLTHTHVIEYQKRGLPHAHILITLAPDDHPLSTEAIDKMISAEIPDPSRYPDLHETVTKHMLHGKCGGNSTQPCMEKDKYGNPRCKRHFPREQNPHTRMHPEGYPLYRRRFCHAVVKGGVIYNDGDCVPYSPYLCAKYNAHINVEAVTTIGAIKYLFKYVYKGPDRAVARVERAANGEGAREDEPVRDEINEFVEGRYISAPEAVHRLFRFSVGRVWPPVNRLPVHLENQQSVQINPNEPLPLDTPPTRSKLTGFFDLCAAAPDGELTTTLLYTNVPRYYSWNKEKLRWKRRVHDRNVIGRIYTVPLRSGERFYLRLLLEVVMGPTSFADLLMFEDVVYPSYRAACAARGLLADDGEHHICLREAAQIETGDQLRRLFVFMLIHATVANPPALLDRHFASLSDDARYHIERYEDVPVNDQTIRLWTFNKIRLLLAANDRTLAFFDLPELTEDEVRLFDRLEERLPRFDRQQCAQDAEAAHARLNHDQRIAFDECLCAVELDVVDQMRDNNLGPQHVFFLLAPGGTGKTFVENALLDTVRARGDQAIAVASSGVAALLLKGGHTAHSTFRIPLDTLPTSTCPVDRESDLALMLRTTKLIIWDEAPMAHRFAVEAVDRLLRDLRETEEHFGGVTMIFAGDFRQCLPVVPKGTPGQIVDASLIKADFWRDVRVLRLTENMRLSSNADAMDEAQLARTRDFAEWLLTVGDGAANMHPYDKIALPDYLLLPDGQRTAEGLINFVYPGLRTVNKESLEDLIQLFSRQAILAPHNATVDRINAKLLEEFNGDYIEYRSADEVVEAGETGGGMAPELILPEYLHSINPSNFPAHHLRLKEGIPVVLLRNLDPDAGLCNDRAGTTVFIPRVRLETNATGSRQLGFTMRRLQFPLRVALAMTINKAQGQSLDRVGVDLSLHPVFTHGQLYVALSRAMSVDRIKVLLPSRDPADDDDDLQAVDRAAAAATATPNPVFYQWEPVKLTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N537</accession>
    <name>A0A2X0N537_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C029g10625 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C029g10625</name>
        <name evidence="2" type="ORF">BQ5605_C029G10625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ14869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N537"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ14869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="117" mass="13211" checksum="D9993DC2117A7EA9" modified="2018-09-12" version="1">MARHWHGGTLSSRQTRRGCHKNSRTKSRHHAAIPGCDGVRCQTWKASAAHHDDVRLQLTGNQGCTGADTACNRPDLIARVFEAKSGNKRHEYKMNGFCLFATVRLSCYWFNFILPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N7G3</accession>
    <name>A0A2X0N7G3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C009g05638 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C009g05638</name>
        <name evidence="1" type="ORF">BQ5605_C009G05638</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY83475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N7G3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY83475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="123" mass="13927" checksum="CFD9F55CA44FBE52" modified="2018-09-12" version="1">MNVQCLPLDREHYFFDCVDSGNVWIAARSVLCDALGLDTIDNTHYTAVQRMFGLPKLKASLRDQEGAGRTIEIFTGLVLEMISSGRWGMQKWGTRMEGVGRRRIILEERLKLRAGGAWGRRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N7Q9</accession>
    <name>A0A2X0N7Q9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C023g09765 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">BQ5605_C066g12815 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C023g09765</name>
        <name evidence="4" type="synonym">BQ5605_C066g12815</name>
        <name evidence="3" type="ORF">BQ5605_C023G09765</name>
        <name evidence="4" type="ORF">BQ5605_C066G12815</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ25112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000134">
        <property type="protein sequence ID" value="SGZ35259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1061"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="959"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1658"/>
            <end position="1684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="449"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ25112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ35259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1867" mass="204660" checksum="6769951770919BFE" modified="2018-09-12" version="1">MPDPPGAQAPPADNPLGGNRASDDESLNTLTREPVTGGTANPPAWSTEATQARLDCEKVMQNTFRVLGIVPSGKSTRRLMVLMHDASTPPSQAPLLARAAQRAVRNDAAPASNVIRVIMDGPGSPRGPVQIALRKHFGLAETPFMFARPEGVVLDPEVEKLFSKCVKLNPIVTKATKRFPIARHMYELVFESDQACLEAAAAGPFSHHGKEMVTELPSASPLNHVVQVRFTLPSSSSATPASVLRQSLDDALTLSFGRAGRTQGYTLMQLQRGLAVDPNGDPMAMTEDGFHCAYLRLHADLFQGSTETQKAALNAALPQEIEILGAKYGLRHEFETHYCAVCDRAGHQWGACRKPVSTPATAAPVPGASTSTSTTGFRVAGKNGKHGGPAALNSRASGTNMIQLGPRANPAGAATGNKDDANDDDGGGESVASTEPEGGDTGKETLTRATTGPTKETQTTTAAPVSTPTSPSPSASAPASPLSGGTSESSATSTTSIASTSPRRLRSSSAPGNRRVTRAGSAMILGASGGDGSGGNSSGVNQVKIIRYLKTLRPAPAAILLQEHHLSYNASREGFESAWPGACIRFTPHVLTLIPDGSPLAGHLLSSTPVVFAGAPRLDGRILRSVFRLEELDVEIINMYAPVQEDDRRDFFGLLHFNAPRPKTLRILAGDLNDCPDVSVDRVSITDRAWTPVSHWQTLLSKIAFNALDTVRHVHSCTPAFTRPHYRGRGEERKICSWSRIDYILVQRSWANRLLSASTLFDAPCSDHRPVVATFALPTSNADAEPPLSLPSTSDFISRLNPTVFDDQDFVASIPGVVDEVYRRLEGTAPLGDVYDAALRAVAVAGHARYRSTRADMRRLRAESQSVMEALEARGEHMNEAERDAYAFAKSRLDQLAVKEAQWLRIRAHVPSVDSREGQSASIRTRLNRRSRQTSIVSLEDVDGTETVDMQEALGIASRHAQSLFTPDPARGDPTNPRRSLLDPIRAAKCYDDDRSDPTFGRRLPRQARVALDEPFTLLEVEAALKKTDSGRSPGPSGIPYELFKALPTYFAPKLLDLFNSIWEGGKMTASLAEGLVRLLPKNKPGANLKSLGAYRPITLRETTYKVLSKVLVARLNGVLGELLPPAQHGFMPSRRSADAGSHLTLLLEKLKSLGTEVFPEGALLSLDQQSAYDRVDHAWIFDVFEAFGFGERFISLLRALYDPETLGVRYLINGFPTELVRLLCGLGQGDPLSCPVWNITFQPFLDALVRRGIALDLQKVWPGGPRAQLTHLAFADDAVVVVESPAALSKLETLSQTWYEATNGKTNTDKTLVLPLGPNWLRDETAQALPTVQEGESFKWCGYAFFRYGDSKLFWTHVLDRIKAKARAARDRTLSPSGRVFYANAHITSTVLHVLSFDIPPQWFIQAAETALTDFVWGGPRRNTVAREFVFQTREDGGLGLISIGDIVHSVALRFWDAVAGSDEAIWAPLARESWRSLVAATRDFSPWGFFSSTARVEKLYRDSTRWGAVVAAARVTLPTIKSELLTLPELLSLPPRLPSLYAEGAKHAYDDADAVAKFAQIADLYWRDEGKGWALVGHRRGFWQHSKEPALRHEHVWARVGQKLKAKALLPKTAVRPARITLKEDPHPRCFNFFGLTRPFTIRKLRRLVNTVRFPGKDGQDRALPGGQPQEPRVKRFPEGTSQSGRQRFWSWLHDRFASAAEQDTHWRLMYDVTPTRKKQHVQGHASSPSCLFCGNDAAVIETVSHYFFGCAYSASYWSGVLRILFDKLGIEDTDIDPSTFTQEQLTMGLPLLRGRGRTTSKWMWVRLACAIGFQRLHLLCWHVHQRFEKDRVVAPPSIPSALRAFNRDYLSRAGFVPGARDWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NNF0</accession>
    <name>A0A2X0NNF0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C013g07133 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C013g07133</name>
        <name evidence="4" type="ORF">BQ5605_C013G07133</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY14857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NNF0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="3">
        <location>
            <begin position="376"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="736"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY14857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="889" mass="98533" checksum="5E5FC75AC5AF9ABB" modified="2018-09-12" version="1">MSPNRPTSSEHASFDELPPPSTASVHPPGQPPPARAVMSSSAAAPTAEEIKALIQQALDVHGRDNRSSSSSPPDTTTETASVPRVPAATSITFEAVNRLKDEATYPRWHRALKALVPTPIFSYLQTGNFPAEWSIATQDQWKDYVRSVLFNSLHPSIQDVYQEDDTPSQVYITLKERYSPRDAQAYAKLIQRFWSMPQIPLSSKDDFDKHLNHDLDLAREIRQGNLDIEQVLVAARLFSTNFNDGLDPWRETFLQLHQGKDRLPSLEETMKSMRVAAHNIIDKRPSAYVSNSDKSGTPPGPCPACKTGPLHWLRECTDEDAKKRFFSRPRPNRSKQNANAKPPAQARLAVASDDPGEISETAPSVSFAATSFLSVTHHMVNDSTAFVELHNTPRVQIGGVGGALSSHGTGVIELVASTGNRIRLSNVFFVPGCPANLISVFALINDGITASFTEDGRVSLDRGGKRVCTGSAKSDRLFHLDAHLCTHTALIAARTPKVSLLTLHRRLGHCSLPTLRKLAKSDQVKEGVLALLHDSGLPAHLWEEATQYYLDCKNLTPHAGIDGGVPDAIWHGIPQDLSRLRTFGCRAWATVPQHERTKLEPKGIPLIFSQRHVRGDRVPCRRATSLRARTALTRPYDRAAPRPGASFGTSRSCHTSNFSVAHAEHRFGVTTIVLAYAAHNASPEAPLDMLPSRDADPAHWHQAMRSPHAAEWQTEAIDEFTSLLNQYKVYVILDQAALPDGAKLLRSHFVFRTKRDQFGNVKSRKVRLVADGSTQRPGLDFQERYSPVVRFTSIRALVAIAVLRGYKIKQADVNKAYLHGKLDQPLYMRPPQGIDLPGKILKLERSIYGLKQAGRIWNDEIDSTLRSVGYKPTVSDLCVYTKRHGNDWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NNG0</accession>
    <name>A0A2X0NNG0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C013g07143 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C013g07143</name>
        <name evidence="1" type="ORF">BQ5605_C013G07143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY14876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NNG0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY14876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="113" mass="12391" checksum="FA534F3D3D880F30" modified="2018-09-12" version="1">MRAGDRLKASLRRGSTKVFQRYLCTIARTRSQGLIKAIPPKHLPSPVKRMASGFAPSFHNLVGNVAENIFVGFEEPVLAVVILSLEDPKKSEPGTKSRYSGNKLGTWQKLVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NUK8</accession>
    <name>A0A2X0NUK8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C013g07377 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C013g07377</name>
        <name evidence="6" type="ORF">BQ5605_C013G07377</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CIA30 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NUK8"/>
    <dbReference type="STRING" id="796604.A0A2X0NUK8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010257">
        <property type="term" value="P:NADH dehydrogenase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013857">
        <property type="entry name" value="NADH-UbQ_OxRdtase-assoc_prot30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039131">
        <property type="entry name" value="NDUFAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194:SF18">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08547">
        <property type="entry name" value="CIA30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase intermediate-associated protein 30" evidence="5">
        <location>
            <begin position="41"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY15473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="273" mass="30334" checksum="5F3075D0A32B569C" modified="2018-09-12" version="1">MASAWRSYLKRSIEHLRDRSADVLRAQPTPIHGTVLPLVTLKSSEDLRQFIKGCDADLGGKSIANLDLGPEGKGRFWGSLSNELHTGRRKEGVIERGGYAGFRTKQRTTVFGTRFWNTELHDFLRLRVKSSGDGMKYFVNIQTDGPGRSGNVILLPGTLSSHTHPPLPPFPTVRSDLFQHRLWLPSPTSPEAPHEWCDVLIPLEDFALTNSGDMSELQIEMYRAKVRTVGISVLGPKQGRYELGIESIDAVSLDKAQVDSARKEPSSASLEKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NUW9</accession>
    <name>A0A2X0NUW9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BQ5605_C013g07058 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C013g07058</name>
        <name evidence="11" type="ORF">BQ5605_C013G07058</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the UPF0743 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY14725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NUW9"/>
    <dbReference type="STRING" id="796604.A0A2X0NUW9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.490:FF:000001">
        <property type="entry name" value="cell growth-regulating nucleolar protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039999">
        <property type="entry name" value="LYAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014898">
        <property type="entry name" value="Znf_C2H2_LYAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13100:SF10">
        <property type="entry name" value="CELL GROWTH-REGULATING NUCLEOLAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13100">
        <property type="entry name" value="CELL GROWTH-REGULATING NUCLEOLAR PROTEIN LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08790">
        <property type="entry name" value="zf-LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51804">
        <property type="entry name" value="ZF_C2HC_LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger C2H2 LYAR-type" evidence="10">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="60"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="153"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY14725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="258" mass="27968" checksum="819C85DA3689C264" modified="2018-09-12" version="1">MVSFVCDTCNDTLKKPKLDQHAQKCWAVYTCLDCNTTFEGTSYRAHTSCISEDQKYQKSVYKAPKKPNKNHPGAPPTPAPTTPATVAPSITVPEPFSTATPVDTPAVVESSSTTAMTNGTKRARQEEQEEKVEVERLKKQRKAEKKAAKKASKAAAATGTEPTATSTPAAKAEETVAPEPATEEVSLKDIKAEIKAFLAQAVPGVLKQSRTLREVKRSVVEMAAARGLNEETEVLEVFEKGVFLGGDKPKKMLKLSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NVB0</accession>
    <name>A0A2X0NVB0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01034 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01034</name>
        <name evidence="2" type="ORF">BQ5605_C002G01034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY29270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NVB0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY29270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="526" mass="58177" checksum="3507B8D8F4DC7873" modified="2018-09-12" version="1">MYQHTVVSAAPACGVGVPIRSHVQALCRALPDVRGEGWRLSRDAVRRRLTLIQEQTFATMPRSQGCQGGPSQPRQVLGARLCRTDSVVSAMANSTLGSPHHHLRKGECAGLESRSNPSSPTFSQGKVRLPPPPQPNLEYRQLLEGLDSDAKAFRENARSYNNALSFTSLAALWDQTQVGTLGPPVFRVFGRLYHRLGALIPAVNQCPAFAQTWLINPAEATDTRLEPDGADSHMQRSTLTKLESMLRTKNHFVGEFASAKPRAGWDTAKEWILRLCLPPGQDRRTHNLPTSSTEMAMLICDSDTNMGDRGPQDRILQSSARSIRLRCLSGSHYYFLQGKMASTPTFLFAGFAKLGCQSPETESRSTMVSNRARYLRVSVLMTEAKRRTKTATMRMKTARKGTKRMVMANDEGQVKGSRWRVSRSPFFAHYLPNATSTSQSRIAPNVPSWRCDGVCCQRGKASAADHDEVRPRLTGNQGCTGADSACNRPDLIARVFEAKSGNKRHAGCFGDECKMNRFCFFAVLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NZX3</accession>
    <name>A0A2X0NZX3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00331 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00331</name>
        <name evidence="2" type="ORF">BQ5605_C001G00331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY45737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NZX3"/>
    <dbReference type="STRING" id="796604.A0A2X0NZX3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY45737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="242" mass="26501" checksum="DE79E90CCF238F65" modified="2018-09-12" version="1">MDDLFLPSARALGSSLSSPTIFTTIFGSCTYPTSPFPTATLPANIALPDSDDENSMAGNDETGTPPPPPSPLSSQPNIVVPPMHVLLTREQFDDLVKKRRSVDDDDVSKRNLLPPTSPPAFPDESKLSDNNYVDWDLTMSLTVPREVCLYLRTGCHDKAWLPELHSRWEDYAARVLAGSLTTVAKGTIGPVAQKGGNAHACWVALTKRYAPSDAQSHSTLIRDFFNMPKLPSTWAGFNEWTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P0M0</accession>
    <name>A0A2X0P0M0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C018g08786 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C018g08786</name>
        <name evidence="2" type="ORF">BQ5605_C018G08786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY26781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P0M0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="366"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY26781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="520" mass="56335" checksum="3712950EEF705037" modified="2018-09-12" version="1">METGDTGPPPPLASAATSVPIGTKETQVPIAAATYATAAIQKTKQTPEQQTQQQHRAKALTQMFKVMGAVPGNRTDRWLQATFATDEYPVATATSLKYSALNANRSIRNIFDFALDVTLTVQGASKASPADKADLLGCVTRLLSPQSPLCFDAEVTLPKHLAAFAPQIRGIQHSSFVRAGVVNHRISVGFVSAKAHDSALTAIGKQKKAHFAKAHHFYHNMVELRINVGVAAVPSRDAIVDSFKSIVTKITAKGYRCKLVQVLRVIHVDNDLAYVHLAGEFSAFIRFDDDALFKAPNNTLKELLPSKVSLATRGNMHTVVRHDYKREAACARCHFVGHVETCALEQERRQKEANNNTGRHNKHHNNPTNTTTNDNDTTNTNNDASEVVPPSCALGTNQLELRNRFAGLEVKGGQEEDAGKQGEEKEQVEEGDKDTGAKADDEDSDSDGNAGAGIDKAGGDGKDDDKDKQDDSSEGSERREDEGNDGDEVMKDGAEEEDEGRATEVEEEVVVVGASLVTWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P4S7</accession>
    <name>A0A2X0P4S7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">BQ5605_C004g02941 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C004g02941</name>
        <name evidence="13" type="ORF">BQ5605_C004G02941</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY69015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P4S7"/>
    <dbReference type="STRING" id="796604.A0A2X0P4S7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF3">
        <property type="entry name" value="NUCLEOPORIN SEH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="54"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="98"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGY69015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="498" mass="51958" checksum="2E68BA73BD361CFF" modified="2018-09-12" version="1">MASQSAISSQHSDLITAVRFSQHHRLATCSLDHTIRVTERDTTTGAYDARPVEWKAHDSPVLDLAWAEPQFGTVLASGAVDGSIKLWSWDHVKGATAAGGTGGATGTTVRGSSGATGFTATLGGRRASSSTKRWSPTAVLTDARGTIRSIEFAPAAFGLKLAAVSSDSHLRVWECLDPVTLSEWSLVNDIDLTVLTAAPSTAQSVTLQGPSLGVSTAGSSTINFPTPASATGVSNPSGSQAQSFDGFNASSSLLSGSDTSASPNRSGIHASVASSSLGTAAVSSMGSSASGGSFDGRKGGTIETDGGWSLSWCKEAWWGERLAVSSGTSGIIRLFHLPDHAPWSNFLNLIPARSSSSSSSYASVPPTASLAWAPASGRSYQLLASGSRDARARVWRIYPPSLDTQDELTLSTGEWRAKVDDELEDLHSHPKSLSRTSNRNAGASGIGTVKVGWNVTGTVLSTAGDDARVRLWKSDFVGRWQIIAVLSTEDAGDEEMEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P5J5</accession>
    <name>A0A2X0P5J5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C001g00206 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C001g00206</name>
        <name evidence="1" type="ORF">BQ5605_C001G00206</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY44824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P5J5"/>
    <dbReference type="STRING" id="796604.A0A2X0P5J5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY44824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="203" mass="22270" checksum="816B6CB733A86490" modified="2018-09-12" version="1">MVNSEVSLKPLLATNVPMIFTLLVSINFTETGYCFVYLRDILEEVAELTGLALQEDSCFDYWVVDDAATSSTHSTPCLASCRYDQLAAFTAATDSSDKVLGLTGFVLDIDSLPAEAAITLRVYEHIKARLPFVNITTRPQGRVDAPVPIKGQRSRGTCGIGKLARAWRGAGWRQMAALVSFTLSFFFNTHSISISPIRLLQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P635</accession>
    <name>A0A2X0P635_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C001g00436 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C001g00436</name>
        <name evidence="6" type="ORF">BQ5605_C001G00436</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY46457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P635"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019783">
        <property type="term" value="F:ubiquitin-like protein peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="5">
        <location>
            <begin position="221"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="440"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY46457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="461" mass="52192" checksum="81296DF2744B21E3" modified="2018-09-12" version="1">MKPCTGSNCSCLQEDHRGIIVTMVWLDFPSNSLQCSTCREEAQALSQCAASFAVSPRMPPINVLSIEDIEIDPIEDENIKEWSHVACIATPKLLNVKLPATDQSEIPLSTDAPQAPFELYFETLPHPPKQARRHFFESNNLSEAKKEGLRSLAVGRYRVPLGFKRIWDNLDNAREARRRIEDALEWMKRVEKECIIDEFYISKAKEALLNLPWHELPGVGNELGHKRLVNLLSNEWVGETIINFLIGGIIHTQQLEHTTTIYGLIPSDCISYAIYRMRHAGGSSDVQRLLGQYQFELWLADWARHDCVGIASTAEFISAHPDSVWFLPICDENHWFLGRIDVKHGAWSIHNSLASRTLTVAALNALEALFKVLNLNIDVNNGTTTMSPQQQDTFSCGPAIVNVVEHELVHEKAFDPTHAALSRIRQFCRAVDMIEAQEMPKEHTRTTHDDTLNPSYVPQFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P647</accession>
    <name>A0A2X0P647_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C001g00446 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C001g00446</name>
        <name evidence="1" type="ORF">BQ5605_C001G00446</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY46559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P647"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY46559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="104" mass="11662" checksum="1E215C2A1FAEC27D" modified="2018-09-12" version="1">MVGMWTPDYHTPKEFNLKDAFRLIQAKTQSNTTVWGRLGPAKQQDIVKYVSCAEPASLVRNVRLLGHSLVILFQIHCSTTVRPVGWRGSWDGFPGRTSQDCATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P7Y9</accession>
    <name>A0A2X0P7Y9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g03942 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g03942</name>
        <name evidence="1" type="ORF">BQ5605_C006G03942</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY54982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P7Y9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY54982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="84" mass="8663" checksum="038F89F09C03A00C" modified="2018-09-12" version="1">MLQKSLKSPRKRVPSVCGRAAAYRKWLAARVTSAGVARGSRLQTSLPCFAGWPATSLGSAGGISQAGHAPKGGKPLLGMCARVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P9Q5</accession>
    <name>A0A2X0P9Q5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C007g04663 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C007g04663</name>
        <name evidence="2" type="ORF">BQ5605_C007G04663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY62199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P9Q5"/>
    <dbReference type="STRING" id="796604.A0A2X0P9Q5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01519">
        <property type="entry name" value="RHOD_HSP67B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE RDL2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086:SF10">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE_RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="78"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY62199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="182" mass="20460" checksum="12FA54E263CC8780" modified="2018-09-12" version="1">MSTRALFRPILTQLPRATRRGVIPTAHPLLARSQWSPPQSVLRSFTSSSIQWRFQDITKFAKGVPITYEELKPITEAPNDDILLIDVREPNEVVQGTIPSAVPLPLSSFEKSLSMDEGDFVKKHGFRKPTKLQPIVFFCKAGVRAQTAIDLAKKAGYKHLRNYEGSYADWIAKDQANAHDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PB67</accession>
    <name>A0A2X0PB67_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C004g02805 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C004g02805</name>
        <name evidence="7" type="ORF">BQ5605_C004G02805</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY67763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PB67"/>
    <dbReference type="STRING" id="796604.A0A2X0PB67"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000100">
        <property type="entry name" value="RNase_P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00825">
        <property type="entry name" value="Ribonuclease_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY67763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="190" mass="21243" checksum="AD8003ED8F5D127B" modified="2018-09-12" version="1">MRPDKPTPHPPAPGLSAVFPPNHGKATHLSPPLLHLLPSLSSKLPKDHPLYHHLVAPRKNRLDPYELQLTIMASKKGVHNSAVVRNRCRRRFKEAVRLVVTREAQGGKGGEGQVVEVDEGGVKGPRRWLIPGYTYIVNLTLEVYKQPLSTMVNEIRQGFLQVKSKTNETAYRNLIDSIEVPEEEEAADSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PBJ8</accession>
    <name>A0A2X0PBJ8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C004g03046 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C004g03046</name>
        <name evidence="2" type="ORF">BQ5605_C004G03046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY69668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PBJ8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY69668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="134" mass="14486" checksum="4E68284C059E3213" modified="2018-09-12" version="1">MVAFAVDNGLSLQPAPSKGQVTNFTKRNIFASPTLDFIHPSILTRDVSDSYRPIPPAMRLLSRGKTYHPGNTVAFKKHLPESLEQADLCVGYYGAVTSIPGEPVPMPPREVDTTASSFGSPTPYPGRTSPVTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PCS3</accession>
    <name>A0A2X0PCS3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C028g10463</name>
        <name evidence="10" type="ORF">BQ5605_C028G10463</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7"/>
    <dbReference type="EMBL" id="FQNC01000080">
        <property type="protein sequence ID" value="SGZ11869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PCS3"/>
    <dbReference type="STRING" id="796604.A0A2X0PCS3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013235">
        <property type="entry name" value="PPP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051134">
        <property type="entry name" value="PPP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08321">
        <property type="entry name" value="PPP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="9">
        <location>
            <begin position="433"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGZ11869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="652" mass="71169" checksum="4E1D14BB72E33D2F" modified="2018-09-12" version="1">MATSAGSTNASTSTDTSMNGNDCSSSSTSPSSIVEPATRSLFSVDDSSSPTSALPSTDSDAESDVGSDYSTASSEYIAPLSGHAPDPSIDGSSVDGGGHSSGANGGGIRPESEAELGPDAKKDALRIKSEANALFSASKYRPSLDLYTASLNKNPFDPIVWSNRAAVRLKLEEYGLAIADSTRAIELDARAVKAYFRRAIANLAIMKPKAALVDLKKVISLDPHNVSAKAQLDATQKLLRRLQFEAAISAKDEVLTSTKILEQLAHGALPIEASYAGPRLPNEEEGKPLRPTNEFVDELIEWFRKGETIPKRLAWQIVLGAYEKLKEEKSLVKVTIPQGETMNVYGGPLHPQHFCPKRLTHADLLDPSMFHSIGDTHGQFYDFYHLLTLTGRPSETHSLLFNGDFVDRGSWSTEIVLVLFAYKWLYPTKVFLNRGNHETADMNKVYGFEGETKKKYSEMTYKLFEEVFTALPLATLVSASSPTNDTSSDTSKNPILCQNKKRYFVVHGGLFSRDDVTLANIAAIDRISLKQPGHEGLMCEMLWTDPQDSAGRGPSKRGVGIGFGPDVTRRWCELNQVTAVMRSHEVRQGGYSVEHDGLCITVFSAPNYVDQVGNLAAFAKIDETGTIKYTTFKEQPHPDIKPMAYAGQMAMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PEL8</accession>
    <name>A0A2X0PEL8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C009g05420 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C009g05420</name>
        <name evidence="3" type="ORF">BQ5605_C009G05420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY80955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PEL8"/>
    <dbReference type="STRING" id="796604.A0A2X0PEL8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="381"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY80955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="744" mass="81338" checksum="95D0F3589AFD451F" modified="2018-09-12" version="1">MAGAQSGDKCVDVGGPEPASPPAHPARDVAQQHSGSPPSTTSSPASRRSRGSTKATTAPSTGSPKGSFTESPTTSPAGSAISSPAGSAITSPAGSAITSPTGSPITSPKVPPRVPSPPLARSFTAQLPWVLRTWMFPSSSEDRTGFQGHEIEWSSLRDFFLSPSPSRDGTAADLGQTESTMNQSLAPRITWQLGDPNLEPQGRLVKTPLRQDREAYDPNEFPDFVVLSRQAFDGNSELASAWAQDHVDAEKDDFRNWEQVAAIGVLGGKKICQDPTLDSAWVYPATRVKHHLRKLAAESPIRSHTFGFTLDGSILTLYLHTPSGLFYSSDIECTESNGHLSTFITRLLSLNDLDLGKIASPGEPDGPPLPFPVAALPPRVPVFAHHLGDGSTIDSVEIAQTVFCSGAVLGLQTSASRVRATRMGVNGEQEYAMTVSFVEEARCDEHDRIRLLIASASPQEREGLTNFVDVHREVNFGLVPHFLKGQSDADSAALKPRAMEVAFQERCFETIWTVDSTEALIRVALGVVKGLRSLHRMRILHRDVSSGNIMVGPDGEGVLIDYDLAVLMDGPFGDAARLERVGTFAFRARHLMEFCGSLLHQPWHDIESLVYVILLVVFMQPTGPESWGRMSEEAATVWKNWNWDEYAYDTKWVLLQRQSNRRELLKPYLGFWEGLPDLIAIVAKYCGLNLSAYMYGSIEAEEYLKSEWGSGELSYDQLVADLEKLLEEIVQTRRERASVSPIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PFF6</accession>
    <name>A0A2X0PFF6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C009g05790 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C009g05790</name>
        <name evidence="2" type="ORF">BQ5605_C009G05790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY85947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PFF6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY85947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="92" mass="9442" checksum="5CFB28FE560B487E" modified="2018-09-12" version="1">MSLELARGFDFARLGCRVAVMDALGVLGRDVDVARACPIEAAPPPPPAPAPVPTTDNDADPLPPADEGAVVVCIAIAGFKVRFVGIVLRGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PHQ8</accession>
    <name>A0A2X0PHQ8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA-processing protein 40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C034g11316</name>
        <name evidence="13" type="ORF">BQ5605_C034G11316</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRP40 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000065">
        <property type="protein sequence ID" value="SGY99959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PHQ8"/>
    <dbReference type="STRING" id="796604.A0A2X0PHQ8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22526">
        <property type="entry name" value="KH-I_Rrp40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05790">
        <property type="entry name" value="S1_Rrp40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000112">
        <property type="entry name" value="Exosome complex component RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049469">
        <property type="entry name" value="RRP40_KH-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041054">
        <property type="entry name" value="Rrp40_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037319">
        <property type="entry name" value="Rrp40_S1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18311">
        <property type="entry name" value="Rrp40_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21262">
        <property type="entry name" value="RRP40_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exosome complex exonuclease Rrp40 N-terminal" evidence="12">
        <location>
            <begin position="52"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="11">
        <location>
            <begin position="213"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="59"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF15985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGY99959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="277" mass="29871" checksum="9AF8D63627812CC9" modified="2018-09-12" version="1">MLRMPRLCSIALPFSNPLYFRLQSLQPSDMTRVLLPGDRVPSTSAASAATTLHLGPGIQSVVVPSSHKGKSKATSDEMDTDEKPGKEAEGDEEDEEVVANRAGLLGLQEDNKSQKYWIEGTSRRYIPQAPEPVIGIIIARHAEGYRVDIGSSQAASLDALAFEGATKRNKPNLKVGTLVYGHLLATPPFSEPEISCVDAATQKAAGFGELAGGFLIRHVELGRCRALLSPKHPILERLGAQFAFEIAVGMNGRVWVKAGDDDTEKLIAMIAELRGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PIE1</accession>
    <name>A0A2X0PIE1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C044g12165 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C044g12165</name>
        <name evidence="8" type="ORF">BQ5605_C044G12165</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000114">
        <property type="protein sequence ID" value="SGZ31393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PIE1"/>
    <dbReference type="STRING" id="796604.A0A2X0PIE1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF81">
        <property type="entry name" value="ER-DERIVED VESICLES PROTEIN ERV41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="7">
        <location>
            <begin position="41"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="6">
        <location>
            <begin position="132"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGZ31393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="397" mass="44028" checksum="7FE4A6876ED93208" modified="2018-09-12" version="1">MAAALPEHSPVLSSSTQASDTVAVPESRGYFNSVLATPPPLNAFDAFKKTNATYKEQTARGGVLTVLLALFIAALVWTELREYIYGEPDYQFSVARGIGHELQVNFDATVATPCHYLTVDIRDAVGDRLHVSDEFKKDGTAFEIGQAQRLQNLHEEVGMTASRMHIVEDGPACRIWGHVTVKKVTGNLHITTLGHGYLSWEHTDHACTFDVDCKRQMKPSRALKLGWLFAVMNLSHVIHEFSFGPFFPQIAQPLDNSVETTNAPFHIFQYFLSVVSTTYIDAGRRTLDTNQYSVTDMSRETEHGRGVPGIFFKYDIEPMSLTIRERTATLLQFLVRLAGIVGGILVCSDYGFRTLDSLFGRMLDDKSKSTLLVTSPAVGTKSPPTLRERAFSNAGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PKL3</accession>
    <name>A0A2X0PKL3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C020g09204 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C020g09204</name>
        <name evidence="2" type="ORF">BQ5605_C020G09204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000082">
        <property type="protein sequence ID" value="SGZ18791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PKL3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ18791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="226" mass="24902" checksum="F75A25CB4CC43A29" modified="2018-09-12" version="1">MPRTEFTRQPDGNACGVFVCRTMETLVAAVAFQSELVWRWSPFKPLQGNFYADQRAYMLEVVKHARLRSDTELKQILTPPPPPLDLREGSGAPPPVPESIPLALKESSPELEEKPLGSPGIEISPPTLILIDPSIGTIPRPNPAPSIATIGSMPDAPPMRLQRVVKFDPTNSLLVSEALEVVACFPRYQTRTLAVRSIAAISTNAPSPRRSKRKREASFFKAARLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PL49</accession>
    <name>A0A2X0PL49_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="19">BQ5605_C022g09426 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">BQ5605_C022g09426</name>
        <name evidence="19" type="ORF">BQ5605_C022G09426</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Spindle pole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CLASP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the TOG/XMAP215 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0PL49"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990498">
        <property type="term" value="C:mitotic spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099070">
        <property type="term" value="C:static microtubule bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061863">
        <property type="term" value="F:microtubule plus end polymerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030951">
        <property type="term" value="P:establishment or maintenance of microtubule cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990571">
        <property type="term" value="P:meiotic centromere clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000022">
        <property type="term" value="P:mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000019">
        <property type="entry name" value="Cytoskeleton-associated protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000050">
        <property type="entry name" value="Cytoskeleton-associated protein 5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000068">
        <property type="entry name" value="cytoskeleton-associated protein 5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045110">
        <property type="entry name" value="XMAP215"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048491">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12609">
        <property type="entry name" value="MICROTUBULE ASSOCIATED PROTEIN XMAP215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21041">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="14" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TOG" evidence="18">
        <location>
            <begin position="2"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="18">
        <location>
            <begin position="312"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="16">
        <location>
            <begin position="488"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="18">
        <location>
            <begin position="666"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="18">
        <location>
            <begin position="933"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="18">
        <location>
            <begin position="1310"/>
            <end position="1566"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="16">
        <location>
            <begin position="1503"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="268"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="550"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1186"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1579"/>
            <end position="1698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1974"/>
            <end position="2038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="2127"/>
            <end position="2158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="2180"/>
            <end position="2218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="562"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1259"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1275"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1579"/>
            <end position="1593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1675"/>
            <end position="1689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1974"/>
            <end position="2007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="2180"/>
            <end position="2196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="SGZ22076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2242" mass="237631" checksum="53149BB0F9B0E427" modified="2018-09-12" version="1">MDGAPPPEENFEAQPIQDRLLWKARVSAYTALITTFKQTVSDTDPAFRPYVSDPASVKEWVRDNNAMAQEMGVAAACSLLEWAGKNAARTRAEVLPSLVEKCLGAARAGTKTKAIELCLLYVAAEEDQAEGVLSDLTPGLDVKQPKVVAGCVTVLKEIVRCATHIEHNTSTSRDTDLLACAHRGFGPKTINIKPILKLLPKIFAHADKAVRLEGTALVMALHAYLGPALDPHLSSLKPVQVKELNEAFADADAKGEEGFGQLKPSRFTLTQQREREVKQAEGALEGTNPEEAEEEKNAAEGGAEDGPPDAFDFAEPVDVLNKLSPDFYTHVGSTKWKDRKELALEPLLAVVKVPRIKNDNYDELLRSLGGMIPSYSNVLCIMLAANCIEAMALGLRDDFAKYRSLVIAPILSRTKEKKANVLEAFAGALDATFASVRSFILSMNEIVEDIVTFAKDKNPSVKEQTIKWCTRCLKVVPSPPQRSDIDQLIAVLSLALADSAEPVRIAAAEALGYLMKVCGERAMGGKIEELDDLRKAKVKEAYEKAETKCTNGGGRGGAVRTAPAAGGSSMPAANKSKPKPMVANKENAPLAARPTASAPAPSAALKIAADPAARPPIVAKKLPVASTSSAPIAAKKPVVAAVSASSSKSAGAAKPAEPLKYKMSQEDAEAQVEAGAIPANLVAQISDANWKTRLEGITALHDWLSGGEIETVESELVVRYLGKKPGWKESNFQVSTKMFGILHLLAERSPSFGKSSAALSVPGLSDKLGDIKLKKPAGDALTAFAEKSSLGFVLSLAYEPMTKQKAPKAQADSLLWVEQALRDFGIIGVSIRDLIEFLKTGLKSSNASVRTNATKTLVTLKLYVGADIATFLQDLNPQLITTIESEFAKVAGEAPPEPTRVGADTAVAASAAAAGPGAKGKGAISGSDDPLDDLFPRVELDRLIPSSAISGLGDSLWKTRKEALEMIQSILEGNKRLKPSPLNDLSTPLKQRLVDANKIVQVLALDVIARIATGMGKPFERHCRLFVAAIVGVLGDQKAPIRAAATACLTAIADAAGLDAMITSFDKALETGSPVLRKDLLAWLEPRFQDEDVVATLELRDLAGPVIACLEDKTAEVRRSAQALLPGIISRVGYQTVLDRTGKLKPASKATVLPLLEAARGQANLVPSSKAPTVASFAATPQANIISQPTSRPASAASGPIAATSKLAPGGLTRPTAVNKSLRAGASISTQSASDDAPASRLGAPRPRVSLGSKPLGASRSSPNPASSGFASVSEGKEAPFRDADPRPKTLRASKETGSLKWVVDGTPRADQVETLLQQMTPYTSPDLLAQLFSKDHNAERDYIAALTALDDCARDPASAADAFGLLPKEFRARLVVNVDVIFKYITLRIGMTSTTITVKCLDLIDDLLVVLGEEGHNLSDYEAWALLISLIAKVGDGKETIRGRVRAIFKALCSVYPYSKVFAALVEYGLVSKNARVRAETAEELGSLFQRHGASALPTGKALPLIAKLISDRDAAVRTAALYAIGHVYSSLGADATWKLVGRIPDKERAMLEERLKRTVTTGDTGASAAAVYASPKVTRSMTPVQRANTPSRVPGPGPASPTPNNAARGIAKPGISRLARPSGLAAPTASSSALGGGDGTRRASGAGLPAPGFVRPPSATATATSRLPPPALPYASSAMGPSSSNGSRGQGAERPPSPIDIALLIDAIETEDLAKCANVLKRVQTEIATNYDALLPQADALIDAITLQMALGFEDLHKDSSHAKLRLCKHLMQTLSSFFDHRTLGQAISTPALTSLLAELTGRLLDTADSSGSDAIASLSKVLNMVLIRIFHHSDQTVCVSSLFTVLQDATIDLRELKGSELEARAKYAELVMKCLWKVSKTVKESLESRALSAPRLLRDINQFLTTTPPAEWRRRAADNIPLADMPLRTVKTILQQVVSVFGEAVFDELEEIDSAEDSFVYQYLFRLASSPSSKRNGSAARSQSGDRASASSMNRQSSTGSFSSVHRESLPARQTAATPSIESEPPSTPKIGTRTAGASLGARASISAANSPGGADIEMNQQLKAIFDLIGDPVRSREGIEALYIFQKTRPEAAPRIASWMANTGNYFQTYLKRALRNLEMADQEHEYQRNSPAVESGVSAATGESKRKPITSAPRLSRVQTITSFIASSASSARPVSASVTASSRPTSTSTTLSPRHSRASLGASGGATGGANCERLSQLQEMFGFNSAAAGGGGKEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PNJ0</accession>
    <name>A0A2X0PNJ0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C049g12450 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C049g12450</name>
        <name evidence="3" type="ORF">BQ5605_C049G12450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000111">
        <property type="protein sequence ID" value="SGZ30742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PNJ0"/>
    <dbReference type="STRING" id="796604.A0A2X0PNJ0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF108">
        <property type="entry name" value="PROTEIN CNPPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="2">
        <location>
            <begin position="66"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ30742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="336" mass="36361" checksum="0B020118BE5E3E9E" modified="2018-09-12" version="1">MVSDRFFGFQDTALLCDHVISTLFSVGSSLANNAPSATPVPVVGGLETPPTSPPPSPKDQPPILGEFVAYALYRTRLPTNIIYQALLLLSRLKARYPSARGTSTSPHRLFLSSLMLSSKISMDDTYSNKSWQVVGQGLFSLREVNQMERELFAFLGWNVVVRDEELAAWVTEVVEPYKVDRDAASSPVLRKTMEERKRRRDEPASAPAHLPTPSPSVSRSPSPDSLRHRRASDAAIAMLHGANADVPSSSQRSTRQSRRSRTRTPSYCSSPSSSRGSSAYSSSTSSPVSGATTPGSPITPAGPLTPSHCVKSFPDPSGETKHTTTSTPARCEIASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PPI3</accession>
    <name>A0A2X0PPI3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C041g11945 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C041g11945</name>
        <name evidence="3" type="ORF">BQ5605_C041G11945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000119">
        <property type="protein sequence ID" value="SGZ33224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PPI3"/>
    <dbReference type="STRING" id="796604.A0A2X0PPI3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="98"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ33224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="170" mass="18623" checksum="89217C60A8C10624" modified="2018-09-12" version="1">MAPRAGWFSAADSLVIEFHTRHPHKPGFKHIQGLNGACPPGGDVKNQQSELTGQTEDPQNWSQAVKSGKEDIWRQAAANKFHSLATKYECFTPIDSSSLPHGTKVLGSRFIFRTKHDQPGKITLHKGQLVAQGFSQCPGIDYNKTFAPVAKFTSIRALIALAAAQNLHVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PPY1</accession>
    <name>A0A2X0PPY1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C045g12231</name>
        <name evidence="13" type="ORF">BQ5605_C045G12231</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFB7 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000115">
        <property type="protein sequence ID" value="SGZ31685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PPY1"/>
    <dbReference type="STRING" id="796604.A0A2X0PPY1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008698">
        <property type="entry name" value="NDUB7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900">
        <property type="entry name" value="NADH:UBIQUINONE OXIDOREDUCTASE B18-LIKE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05676">
        <property type="entry name" value="NDUF_B7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGZ31685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="87" mass="10386" checksum="A9729195BCA16FF8" modified="2018-09-12" version="1">MGAHATGPFEPQPAAPELANRARLPIGWRDQCGKLLVPLNVCRHENLYMTWKCDHEKHVYEKCQYDDYMNRMKQLEKAERKRREEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LRE9</accession>
    <name>A0A2X0LRE9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C013g07302 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C013g07302</name>
        <name evidence="10" type="ORF">BQ5605_C013G07302</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LRE9"/>
    <dbReference type="STRING" id="796604.A0A2X0LRE9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015489">
        <property type="term" value="F:putrescine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11476">
        <property type="entry name" value="SLC5sbd_DUR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031155">
        <property type="entry name" value="DUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154:SF4">
        <property type="entry name" value="UREA ACTIVE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="378"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="507"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="569"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="601"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="646"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="651"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY15247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="695" mass="74534" checksum="77BB7E028693D2FC" modified="2018-09-12" version="1">MSEIVPPLSQGAGYGVVVGLGALFAIGMVGISDLLSRRGNTDDNEEFTVAKRSIGTGLTAAGVISSWTWSTTLLSSCTVAYQYGVAGAFFYAACNSTQIMVFSNLAIQTKRKAPNAHTFLEIMRVRYGTFVHLSFMFFSLAANTLVVSSVLLGGAAAVNSLTGMSIYAALWLFPLSVAAYTLRGGLRATILTDYAHTSIILIILLIFWFVAYTTSSQVGSPDRMYDLLIEAQNRNRDAPTLDHSYLTVRSLGALKFAILSILEYTGVVFLDNSFHQKGIAAAPEAAIPGYVLGGLSWYAMPFTLATTAGLVAVALEHTPSFPTFPRRMNASEIGAGLVLPYRASFRSAAQTIMGTGGAAAVLLLMLGPHPQFMSCTSAISAQLIGVSTVISYDVFKTYVRPTANDRALLKASHWAVVGFSLWMAGFGSMLHGAGIDLGFIYNMTGIFTGPALPPLVLTFFSSRQGKVAAGSSIWVGFAAGVIAWLSLAHKFSGEVTVASVGKLDPCMYGCIVGIGSSALVTIVLSLAFPANYDWASLAAVRVLTQNGDQIDVSFEDPSYNPEKLRRAALWARSITLFLFLALFIVWPLSMYGDGYIFSKKFFFGWVVVALLWGFFAFFAVVLFPLVEGRHTLLSIFKGILHGRDGTTSNKVDTKTDEKPVSIESEKLTTTPDSDSAKGKLDESSSSAEQSREGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LRY3</accession>
    <name>A0A2X0LRY3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="22">BQ5605_C012g06775 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">BQ5605_C012g06775</name>
        <name evidence="22" type="ORF">BQ5605_C012G06775</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LRY3"/>
    <dbReference type="STRING" id="796604.A0A2X0LRY3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0229">DNA integration</keyword>
    <keyword evidence="18" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="16" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="15" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="16" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="17" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="21">
        <location>
            <begin position="416"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="SGY16147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="650" mass="71137" checksum="0C8B599AECADF0C3" modified="2018-09-12" version="1">MSTTYARKVCAYLRKGQHDLSWPPAFHTRWEDYAARALASSLTVTTKATIGPLIQTGGSAHDCWLALAARYAPSDAQAYSTLIKDYFSMPPCPPTCWLTTFYAVKVQDNKLPRVEQIFASMETVARTLRHDPTPALAAKPVATTKPSASGKKGRWDCSGPAPSNCPACGQGKHWVDKCPDTRKRAKYFELRNAMKELQGTSLLQAPAFVATKEASKDLDMSFFSSPTFVSFGVPNIFLLDLMSACHVINNASFFNGPLAPTSHILQGLGGTVKASGVGSVKLVSDIGTEFTLNNVIYAPESPANLVSVRAFDRKGVRITFECGQAELRMQQGRIATASAIASRIYKLNASVRTPSPGAIHTLVTTKSHGIPLLTLTIVTVEGLDWTYSDLKCVDFTCNACLASKAHRLPFPPSLFHALEPLALVHSDVLSFPEELFSHKRYLVTFVNDFLRKTWVYPIGHKSEVLQMFKDWLMEIENETGRKVKTLRSDNGGEYVSTAFNGFCVARGIRRKLTIPYTPEQNGRAEQLNRSIVEGTLALLINSGLPCTCWDKAAMCYIHTKNLLPHAALKGGVPNCRWSGAPPTVVKGTRSLSSLTGDLADRCKLYGLQLASGVSPIYESAEIWNTSTHLASGVSPMGRELKKLGARNLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LRY9</accession>
    <name>A0A2X0LRY9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C012g06785 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C012g06785</name>
        <name evidence="3" type="ORF">BQ5605_C012G06785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LRY9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="365"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="962"/>
            <end position="988"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY16165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1171" mass="131108" checksum="F30CEEE58B8C3633" modified="2018-09-12" version="1">MVVTAWIGKKARSFYWIVFCRLPTAQQPALETQPRRAIGRCRVKKKKIVQRSWANRLLSASTLFDAPCSDHRPVVATFALPTSNAADAEPPPALPTTSEFISRLNPTVFNDQDFVDSIPGVVDEVYRRLEGTAPLGDVYDAALRAVAAAGHARYRSTRADMRRLRAENQSVMEALEARGEHMNEAERDAYALAKSQLDQLAVKEAQWLRIRAHVPSVDSREGQSASIRTRLNRRSRQTSIVSLEDVDGTETVDMQEALGIASRHAQSLFMPDPARGDPTNARRSLLDPIRAAKCYDDDRSDPTFGRRLPLQARVALDEPFNLSEVKAALKKTDSGRSPGPSGIPYELFKALPTYFAPKLLDLFNSIWEGGKMTASLAEGLVRLLPKNKPGANLKSLGAYRPITLRETTYKVLSKVLVARLNGVLGELLPPAQHGFMPSRRSADAGSHLTLLLEKLRSLGTDVFPEGALLSLDQQSAYDRVDHAWIFDVFEAFGFGERFISLLRALYDPETLGVRYLINGFPTELVRLLCGLGQGDPLSCPVWNITFQPFLDALVRRGIALDLQKVWPGGPRAQLTHLAFADDAVVVVESPAALSKLETLSQTWYEATNGKTNTDKTLVLPLGPNWLRDETAQALPTVQEGESFKWCGYAFFRHGDSKLFWTHVLDRIKAKARAARDRTLSPSGRVFYANAHITSTVLHVLSFDIPPQWFIQAAETALTDFVWGGPRRNTVARDFVFQAREDGGLGLISIGDIVHSVALRFWDAVAGSDEAIWAPLARESWRSLVAATRDFSPWGFFSSTARVEKLYRDSARWGAVVAAARVTLPTIKSELLTLPELLSLPPRLPSLYAEGAKHAYDDADAVAKFAQIADLYWRDEGKGWALVGHRRGFWQHSKEPALRHEHVWARVGQKLKAKALLPKTAVRPARIPLKEDPHPRCFNFFGLTRPFTIRKLRRLVNTVRFPGKDGQDRALPGGQPQEPRVKRFPEGTSQSGRQRFWSWLHDRFASAAEQDTHWRLMYDVTPTRKKQHVQGHASSPSCLFCGNDAAVIETVSHYFFGCAYSASYWSGVLRILFDKLGIEDTDVDPSTFTQEQLTMGLPLLRGRGRTTSKWMWVRLACAIGFQRLHLLRWHVHQRFEKDRVVAPPSIPSALRAFNRDYLSRAGFVPGARDWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LSF2</accession>
    <name>A0A2X0LSF2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C012g06828 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C012g06828</name>
        <name evidence="1" type="ORF">BQ5605_C012G06828</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LSF2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY16279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="51" mass="5439" checksum="4C9970FB36688FE7" modified="2018-09-12" version="1">MLSCDQGSLVIHEAARAGSFRGGCKAGRRRSELPGREVARRADALWRAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LSH4</accession>
    <name>A0A2X0LSH4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="27">BQ5605_C012g06848 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="27" type="primary">BQ5605_C012g06848</name>
        <name evidence="27" type="ORF">BQ5605_C012G06848</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="19" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="10" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0229">DNA integration</keyword>
    <keyword evidence="21" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="18" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="17" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="18" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <keyword evidence="4" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="20" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="26">
        <location>
            <begin position="856"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="603"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1131"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="603"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="25">
        <location>
            <begin position="613"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="SGY16338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1749" mass="193758" checksum="56C4411BEA6BE935" modified="2018-09-12" version="1">MCRSLHRRIIAGDAGRLFSRRQSSRRNPNKPAVSIFACTMWISINGSDRMGLRSLSRSSTVKRPFMVAEYLVSFQDTVFIGHGAYALFWLTTIKGTVDFLYVLFGLDLLKFALKMIGAGTAVFSECTLASRSAAGSSGSITAWKKSKVTDNDLNGAPLGRPWGNQARTVYLNNFMDTHISPSGFAPWLPDNPNLGSLFFAEYGSFGPGGSMAARSAFPPGTPFDTPVTDVKQMEHILDSNEASRITFPFMFHGDISWVDPDCASRSGRTYGLSSGAGARVLCGGPAEAAGCLHEIASFWPSCFSLFSTTHSISHLAYRLTFSDPLSHNRSSIRRHVTRDAPTTTGYEPNELPAAQESGEIKIAKLGKDNYELWSIRVEAYLESKGYASVLEHGHVRPSDVSLAEWRTMHGLDASVTDTQVVVNLQKKDRSARALIIQCIDDANLKMVKSKTLSAKDIWDKLRQHHEGNAKPFKIRTLLMELSNAKYDEDENMGEFLKSMIDKADQLDDLGQKFGDEAMIAYILQALPPSYEMLKQAIRLGENRSVDHVINRLTDEYTERKLSGKFDKLLKNAGALAVQSTQASRDPNCVCRGCKGKGHFAMDPECPKYDAKKNHGRARNRNKKKKQDSKESADSNELAEFVLTVKSLDESHSLQDNVANRVSQLNQGEIWILDTGASQHYVGDASLLSNRQSGNLKVQTASGQVVHCDTYGMVRFKLKSGASLSLANVYHLPGAPVNLISTRALFKSGAKCGWEDGKDVMTITYQGVILAKTLSGTGYALDFTRIVEDQAHVATRATVGAPLMEWHRRYGHVPVSSIMELVKSGAVEGLVLTDEKVHDCEPCISSKSRASKFSELATQVTDVLQRVFMDIGFVAEDQVDFQGRKAYLAIVDQYSTAKWTFPLKTKSAEEVTRVWIAFRQGVEKMTGRKIKRVRTDNGTEFTNKLIGADFQSQGILHETSAPYTPQQNGTVERFNGSLMAIVRAVLAASKLSWKYWSYALAYATFVANRILHAKLEGKTAYEVFYGKKPKVSHFRPFGSTVYAQVPKSKRSKLESTSVKGIFIGYDSEYNYRVLVDPDSDHKVIVTRDISVLEHKSEQVGVPEVTTLPVGPDEEKGPVDNDEIVVDELQDQVDGEQMPPARQNRPRWEYGDPAVKGRNPGRYEEIDANNEIPHRTRSQRRDAEQQVMYGSAMSVSLPPVPSNYEEAMASPEADKWIAAIKAELDAMARHQVLIDSDLPSGARALGSKWVFTRKENAQGEVTRYKARLVAQGFAQRPGIDYNETFAPVARPSTMLSLVGTAAAQGLFLEQFDFDSAFLNGTMTEMVYMKYPKGWDRPQTGQALRLVKSMYGTKQAPREWNAAVNSLMVERGYKRSDADSCLYVKRVDEKFIYITLYVDDGMVASNDQEFLDSEIEAFNKVYKLKRLGPVKLFLGLEFERTSDYIFVHQSKYIRDLVAMYGGGSVSKHPVKVPMEPRSDVEHSTDPFDDVALYQPAVGALQYAAHRARPDIVTSVRAAASKVSAPTQADWIAVKRIIRYLQGTVDWGLKFNHGGSTVFELYSDASWGDDMSTGKSIGAFVSILAGAAISWQSKQQSMVATSTTEAEILAASAAAKEAMWLRRLAADLELEQPKATLIWEDNQAVIAIALNPAHHGRTKHYNVHHFYIRERVTAGDIRIKYCKTGAMTADILTKPLARNLFELHREGMGMVGAGARVLCGGPAEAAGCLHEIASFWPSCFSLFSTTHSISHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LTG0</accession>
    <name>A0A2X0LTG0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C015g08030 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C015g08030</name>
        <name evidence="1" type="ORF">BQ5605_C015G08030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY18287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LTG0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY18287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="124" mass="14368" checksum="03D252D119228B59" modified="2018-09-12" version="1">MVRSFALVKIYGMAREGRSLVSGQYPRVKARLVSLYWIAFLSAPTAQQPALEIQPREDIRRCRGDEIAIYEPQSKNKIKFYKYPRVKARLVSLYWIALLSAPTAQQPALEIQPREDIRRCRGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LV58</accession>
    <name>A0A2X0LV58_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C016g08075 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C016g08075</name>
        <name evidence="2" type="ORF">BQ5605_C016G08075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY20491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LV58"/>
    <dbReference type="STRING" id="796604.A0A2X0LV58"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY20491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="413" mass="45723" checksum="9D104BE5F202F644" modified="2018-09-12" version="1">MTTMQPILALRHVYEPAASAPGSNRAQTPQAHVSIRDDLGPQTAVCTHCKARHWELGPPVFRVFGRLYHRLGALIPAVNQRPAFAQTWLIDPAEATDTRPGPDGADSRMQRSTLTKLESILRTGNRFVREFASAKARAVWDTAKEWILRLCLPPGRDRRTHNLPTSSTEMAMLICDSDTNTGDRGPQDLILQVHGDRCPDGRPKYQIVSSLHPSAMPLRYPLLFPAGEDGFHPNISLCGFRQAGLPITRNREQIDNGVQPREVLAGLSLDDGGEEEDEDRDDEDEDGEEGDEEDGDGERQVKGSRWRVSRSPFFAHYLPNATSTSQSRIAPNVPSWRCDGVCCQRGKASAADHDDVRPRLTGNQGCTGADSACNRPDLIARVFEAKSGNKRHAGCFGDECKMNRFCFFAVLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LWA3</accession>
    <name>A0A2X0LWA3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">pectinesterase</fullName>
            <ecNumber evidence="3">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C012g06844</name>
        <name evidence="9" type="ORF">BQ5605_C012G06844</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pectinesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="3"/>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LWA3"/>
    <dbReference type="STRING" id="796604.A0A2X0LWA3"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321">
        <property type="entry name" value="ACYL-COA THIOESTER HYDROLASE YBHC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321:SF137">
        <property type="entry name" value="PECTIN METHYL ESTERASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016111234" description="pectinesterase" evidence="7">
        <location>
            <begin position="29"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase catalytic" evidence="8">
        <location>
            <begin position="205"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="452"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="456"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY16323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="478" mass="50909" checksum="98F889B8FE097A5D" modified="2018-09-12" version="1">MLLPVAPFSSALLLFTNAALSLLPSIAAKHPNDKRLACQGFTKCFEPKNCPPGTLYVSRTDSDAHFKTISAAIASLPSDTSAKTIVVGAGHYQEQLNVTRAVVPLRELKLQTPRSGAHQPWVLTTKFTPDPKQGQTGGSTTNQVTVFFSKGTTQVSVGGVFQSSNIDNGATAVLSVAPSYNASLTGAGYTGDPLITDPSQSGCSDFRMYNMDLDQEWGPVNTGPALAVSVSYANASFYGVGVFGYQDTVYAGHNASVLFLDSDIRGATDFLYGFGSLWIESSTLGSRGAGGGIVAWKGSVQPAGNLYGALVTKRSARAQRIAPDLNATLNITHKVALGRPWNNASRTIYLDTYMDDHILPAGFIEWSATDPRLNFTLFYAEYNSSGPGFNATARAALTAGTPLTAPATDAQHIEHILTAPQANMSSFSKVFGSNLGWADFFYDDGSFAASVGDRQHRSHGHKRDSHTRKVKGAGRVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LWA9</accession>
    <name>A0A2X0LWA9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C019g09017 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C019g09017</name>
        <name evidence="3" type="ORF">BQ5605_C019G09017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY24168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LWA9"/>
    <dbReference type="STRING" id="796604.A0A2X0LWA9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY24168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="713" mass="80055" checksum="B7C3FE7EDD39AF81" modified="2018-09-12" version="1">MATQDILASLPTAVPLLIVDSILNALTHPNPTRRRVGLALVLLYCVLALRLLAVARHMSLASAPAPLSRLAKARSTSSRDPDDGQEVPVYDDSPPVSSIQRDNLARLVHLVDTRKSAYPPRRLTEMALQHPSNRLVAVTAVVLHWKRRRGLQLVLKQLSRYPFIREIIVWNNHPGVSLKASDFFISPQPSSDLPQPRLRIFNSPSNVHDAGKHFACSMATSEHCYFNDDDWLNIYLDSLYTKYIDTRSGIISGSASASTSSVAVPRIVSNTMPVIHLEHHVNLHTGFTWIGCGSFAPKALSVRFLNQQTAAPVMLTRDQTLVSDMFFSLWTNTYPEQMPNDLVPIDVEGGDVGWSTGVDQWAIVYENVVSSYDRAYSLAYIDLGASIPSFPQLDAVRKLHDILTVQDTYLVPDPFPTIASPPESQLRAPCANDKCLFMTSLTPFPHPSTLIYPLPIKPSFWANLFSRKPRHRELMSRYGLPSSTSSDMDPKFDPYAIDHMHEHEARFNAMPNWPTDEWWTRNGSWHLAVDGKPHDQTCWSTLKGSFHPISTNLNTFVPRSDCISPLIAPDADDYFGLSFIRPRAVTHFTIVGSTTLLNLVSWETPDQTAESWQVFTTREHAIPHEVGGWEPRRFVGSIKVRQLRVGIIEIKGELERQHPRDEELEQKDVDLMEEGEADDILPVVKIAKIKFVSQGRKVEPLSVCGFDLDGFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LX49</accession>
    <name>A0A2X0LX49_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C015g07829 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C015g07829</name>
        <name evidence="5" type="ORF">BQ5605_C015G07829</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LX49"/>
    <dbReference type="STRING" id="796604.A0A2X0LX49"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11296">
        <property type="entry name" value="O-FucT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="75"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY17595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="625" mass="69202" checksum="59F0C3D70CEABB15" modified="2018-09-12" version="1">MSSALGRRPSYGYSNDPDVAADGVRPASSPSTSASITSLDELTTSNTLLNISRTNLPTSQKGEWSRANSVVASFWPMSSGQGQGQSQPSGAPRGSVGPPMWVDGGDDDSTIKRRKSYVELDIDGTDGSDAPRYRSTHKPSNILNVLSSTLRSTLRAPRRILVLLLLPISVYVVYRTAIQSRSITNESSVDAMVQLYRGSWIGETARGAAGIRYAFGKLIGAYGGEWKGEVPARKNPLKTRIPLKSFRDNLRDDHGYVTSFPYGGTILGEDVWAANQLMEILKLVHLGQLLNRDVILSELMATHEHAPNVGYSRFFDLDLFSFLTNVSIMEWQEVKIPLETGTTPEKLSCWGWQDNAPLKGYNVQTFFWPPPGQLTVPSSIQTSMSFPAMEVLASQSNRKWLDESAQRIYGGWENAPDPPDTKLMCFENLFYVPSIHFVEGAVDQSYTIEELSPNDPVWTSVGQHLHYNAHISHIADELLTFMMGRSGARKPFIGVHLRRGDFVSLGRIAGDDVGSYTRAVIEVQSELRKKRKWSGIGGKRDLPVIFATDATDDPFLNKLADLGWLRINHQEFATDVRFGGWYPSMLDSLLLSRAVGFVGTKSSTYSYLTARRVETWNDGVTRIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LXL7</accession>
    <name>A0A2X0LXL7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C002g01066 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C002g01066</name>
        <name evidence="8" type="ORF">BQ5605_C002G01066</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY29558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LXL7"/>
    <dbReference type="STRING" id="796604.A0A2X0LXL7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1440.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020929">
        <property type="entry name" value="Ribosomal_uL5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057266">
        <property type="entry name" value="Ribosomal_uL5_euk/arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_uL5_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003258">
        <property type="entry name" value="PRK04219.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00358">
        <property type="entry name" value="RIBOSOMAL_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL5 N-terminal" evidence="6">
        <location>
            <begin position="9"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL5 C-terminal" evidence="7">
        <location>
            <begin position="66"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY29558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="177" mass="20159" checksum="3F66512079AE7D5C" modified="2018-09-12" version="1">MAETTKAANPMRELRIEKLVINISVGESGDRLTRASKVLEQLTGQTPVTSKARYTVRHFGIRRNEKIAVHVTIRGPKAEEILERGLKVKEYELRKRNFSETGNFGFGVDEHIDLGMKYDPGIGIFGMDFYVIMGRPGGRVARRKRCTSRVGAPHRVTKEQSQNWFKQRFDGILLGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LY65</accession>
    <name>A0A2X0LY65_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Multifunctional tryptophan biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="16">Anthranilate synthase component 2</fullName>
                <shortName evidence="16">AS</shortName>
                <ecNumber evidence="16">4.1.3.27</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="16">Anthranilate synthase, glutamine amidotransferase component</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">Indole-3-glycerol phosphate synthase</fullName>
                <shortName evidence="16">IGPS</shortName>
                <ecNumber evidence="16">4.1.1.48</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
                <shortName evidence="16">PRAI</shortName>
                <ecNumber evidence="16">5.3.1.24</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="20" type="primary">BQ5605_C002g01203</name>
        <name evidence="20" type="ORF">BQ5605_C002G01203</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3 16">Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 16">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="16"/>
    <dbReference type="EC" id="4.1.1.48" evidence="16"/>
    <dbReference type="EC" id="5.3.1.24" evidence="16"/>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY31026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LY65"/>
    <dbReference type="STRING" id="796604.A0A2X0LY65"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000136">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000031">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00134_B">
        <property type="entry name" value="IGPS_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050472">
        <property type="entry name" value="Anth_synth/Amidotransfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016302">
        <property type="entry name" value="Anthranilate_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418:SF4">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001382">
        <property type="entry name" value="TrpG-trpC-trpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 16" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 16" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="17">
        <location>
            <begin position="32"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Indole-3-glycerol phosphate synthase" evidence="18">
        <location>
            <begin position="260"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="N-(5'phosphoribosyl) anthranilate isomerase (PRAI)" evidence="19">
        <location>
            <begin position="639"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR001382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="SGY31026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="825" mass="87520" checksum="2546F2540F933109" modified="2018-09-12" version="1">MAQSHTAAAAQANSMLPSASAAPLIAKDNDVVMLDNYDSFTWNLYQYLCLLGANVTVIRSEAITLEQLAEQHPKLTHLIISPGPGHPLRDSGISIPAIKAYAGQIPILGICMGLQCMYAAYGGEVDKAGEVVHGKTSAVNHDGKGLFKDVDQSVQATRYHSLAAKLESLPEELEVTSRTESGIVMGLRHRRYAIESLQYHPESILSEQGKLMLANFLSWTSGEWSGNPGYEAAGTSAASGSIRSSEAIAIPSPAALPTILQKIENQRAIDVAKAKATPGFKPADLASLINLHVAPPLISFHQRLQASAASSTSGGAPHIALLAEVKRASPSKGDLVDGSSPSSPSIALSYALAGASAISVLTEPKWFKGSLEDMRAVRAAVDSLPNRPAILRKDFILDTYQIDEARVYGADTILLIVAMLTDEKLVELYQHSLSRGMEPLVEVNNAEELVRALKIGSKVIGVNNRNLHDFEVDMGTTSRIADVIREQEGGKDVILIALSGITGRKDVVNYMQQGVGAVLVGESLMKAKDKGAFVRELLGLPQPVPVIEPVAAATEATAQAAVSAAASSPPKTLVKICGLKTPEAALVAAEAGADFLGLVFVEASKRKVSIDQAKKIVDAVRSRPLSGPPSSAPLAPSNDWFSFQAARLASHPRKPLIVGVFQNASLETLLTTIDALQLDIVQLHGGEPIGWTRLLNVPTFKGFHVDAQVELGKDGLESVHLRDATRAGYHAVPLLDTKIGKGENALSGGSGKTFDWSVAKRLVESRGEGHARLPIILAGGLDCVNVVSGLQQVQPWAVDISGGVETNGEKDFDKIRKFISLVKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZI4</accession>
    <name>A0A2X0LZI4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C016g08203 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C016g08203</name>
        <name evidence="3" type="ORF">BQ5605_C016G08203</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY21157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LZI4"/>
    <dbReference type="STRING" id="796604.A0A2X0LZI4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013665">
        <property type="entry name" value="Sfi1_dom"/>
    </dbReference>
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        <property type="entry name" value="Sfi1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sfi1 spindle body" evidence="2">
        <location>
            <begin position="414"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Sfi1 spindle body" evidence="2">
        <location>
            <begin position="600"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="Sfi1 spindle body" evidence="2">
        <location>
            <begin position="759"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="986"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="999"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1024"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1041"/>
            <end position="1052"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY21157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1085" mass="124530" checksum="9EF430FAD361BB20" modified="2018-09-12" version="1">MVASQNGYDHGGSIAGSSQTTSTSSLTGPFPVVTRQQHAILERVVAAVSPPEANDFNSLQQAYARLGLPENDDETYNLLLRLMWEKGLNWVEKWSSANSSLKDRGYAFASVLHRQKDPRTPSNDQKGRRAGVGNIDVLKAKLDQVTPSNIPARSSSTQLRRDPRRQSPSDADLTPANHRETGLTPKAKRVFLKRRGEGGYSSSDDYVGVPSPPNHRSGGSAALPRSAFSSPSLVKLAQAAEEAPTTSKHVKRVSTSDSPIIASFPGHPLMSNRTRSHSSSAHPILSSRIASALSSKADVATKSYLDREDPEMAATGVAFDRLRALNPLFSHWRAKTAWLLDRAHGIEVARQANIKSWALDRWKHNFVEVMVRRADLERAESQWRLRQDTRLQRDVLGRWQIRRRYKQRAEWEGRLRSAWEEVVHNRKQRLVKSVIKFWHRTILERRARRFQESRLVNLAFTIWRWRYERLRSMQDMADNVLKQIGTSTMSSAMHIWRERLRLRSSEVAVSDARDLDLVAKVWDYWRMNTNQRQYVQELEEVANDFQRRKRRHELLSIWREQVHRRKQCAALARRHYQIRLVNRVYTLWLVEYAGRKYLADRNTKLGHASLVKWYTRARLVCIELEAKADTVLAQSGQNLLGGAWQQWCEVIKQRREASEFAVCIHEGSLVKRAMAKWRQRLDKSVVRERQADVARDFLLQRMAWNRWWDAIAERERERAVARIAQFLTTREINLKRAALSGWIDMTLRAQSDRLKVETIGKISNHVLLKRCMETFIGRVVDLRDREDRAGQDFELKMKRLVLFRWRQRSSKIRQFEELATTHREMKEREKSKVALIKWSTRARSSQALHIALAKRRSSMLESCFDHWRERSMRSREMHVVHSIGDHILVDTWSRWVERTMALRVISNRRARTRAQVLEIWRAKTTPVELVAMAVELDQIGTQSRAFQIWQIKAMAKKKLRSVSRNRILGSSTTSSSAYASFVSFRSSPSPSPIRAHFGLTSSPETTPTRPQPLSYDVLERTPEPASPSPASPTPLPPPYLNRTNGSRGQSESSEQDSRSATDGGGARARLRAAAAAARAQTLGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M0Z1</accession>
    <name>A0A2X0M0Z1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C003g02155 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C003g02155</name>
        <name evidence="8" type="ORF">BQ5605_C003G02155</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M0Z1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF102">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="496"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="570"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="110"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="58"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SGY39134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="644" mass="68397" checksum="9BB917212873F75E" modified="2018-09-12" version="1">MIAKSKGPALPIRELDPALPHPSETSTLFSRNMNAERPFNLSGSTIADGNATAVAAHKSTDAGVVAQHPSRDGHDQHAPLQTSSSTSSGAPIETTDAATCSEKGIRFWLIIVSLMLATFLAALDVTAISTALPTIAEALDSREFAWIANAYSVTSCAFIPLAGGLSAIFGRREVLLVALAFFFVGSAMCGAAKSIDLMLAGRALQGVGAGSILTLTEIVLADLVPLSERGTYQGLFGAIWSLASATGPIIGGALAQAYWPALFYINLPLSFFIAIVVTLCMKLKKPPGIRQENLARIDFLGNFIFIVSITLLIIGLVWGGAPYPWSSAHVLAPLIIGIVGLLVWGVYESRYATHPTVPFSVMKNRTTIIGFFTTFIHGISGLALFYYWPTYFQAIKGAGPIKSAVDFFSVAFVVAPFAMVAGASIGIFQHYKAQNVIAWVLMTVGPGVLSLVTAGSPKKAWVPLPIPFSIGMGLLYAATVFPVLAPLSPVLAGPALGFLVFIRSFGNLLGVTIGSVILTNELKQKAPQEWLTSIPGGVSGAYALIPSIASLPEPLRSTVRLAFAHSIQRIWQVMIGFGGVGLIASLFMKSLALQTETDEVKISTLCSSAFFTINPELCATQNFGIREKKAQDEEHTPETKEVLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-11-27" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M303</accession>
    <name>A0A2X0M303_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C002g01622 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C002g01622</name>
        <name evidence="1" type="ORF">BQ5605_C002G01622</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY34375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M303"/>
    <dbReference type="STRING" id="796604.A0A2X0M303"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:RNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384:SF16">
        <property type="entry name" value="GROWTH REGULATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY34375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="327" mass="36548" checksum="257CA48FD4B8DDAF" modified="2018-09-12" version="1">MEYQSDPSSSTAPTNVSLGLRGHRLSLEREALMELPESVLLCLFPNGVVLSAQRQPRLDGTQDVDDGEDVYFVDFDAKCLEFVLNFFATARDAFYGPPQGPRRNLSESAQAAANNIPNPLFLKQAIIVLREELEYFAIPPKGKFSAAADSFIDEKHPPTTADEVAGTDEAGKPNKSLLQLKMDCGKALLERKSIFTALQRNVNRENNVAEQHLIDMLCMSGFERDDAWGYRSLEPNRCCIASIALVLLKTGITHPPITLPEGETVRSSVDVNAQQLATAQKLLLFWRKPARKCWWDATELTLDEGTDQARQIKVWARRVWTLELSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M545</accession>
    <name>A0A2X0M545_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="20">BQ5605_C006g03819 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">BQ5605_C006g03819</name>
        <name evidence="20" type="ORF">BQ5605_C006G03819</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY53930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0229">DNA integration</keyword>
    <keyword evidence="16" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="19">
        <location>
            <begin position="237"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="18">
        <location>
            <begin position="493"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="19">
        <location>
            <begin position="666"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="SGY53930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1553" mass="174658" checksum="DC53969850EB6DD7" modified="2018-09-12" version="1">MPAGYWSRQYSPAEGNYAAHEMELLAIVEALHHWRADLLGVRFKILTDHHSLAGFMKQPSLSRRQARWTKRLADYDFEIVYVRGPENTVADALSRYSFPEDCATRGASDDVNMLAEATLDPAFLKALKDGYLNDTHCQQAIKNIDSTPGYSYKDGIARFEGRILLPKTGDFRENAIHDAHDATGHFGLHKTYERLRRDFIWSGMKESCKEYVESCSVCQTMKMHGTGFAGRIHNLNVPDRPMREVGLDFVGPLIPSNGNDALLTVTDCLSGYVRIIPCRTTDNATTTADRFFDGWHRYFGMPRVLVSDRDKLFTSEFWRAYTGRMGTKLAMLTAFHPQTDGRSERTNRTVIQVLRTMVNRRQNDWSKHLATVEFVINSSVNRPTRATRYGKLEPEFAVGNRVLVDSRDRQLRYKADGEARSAKFFPRFDGPYEVLAARPETSNYKLKLNAGDKSHNVFHASKLRHWTDNDGAAFPGREATEPASVVVQGNEEWEVDRIVDEKGKGKRKRYLVKWKGWADSDNTWEPRAHLEETIVLEEWERERAEGERGKEGRCKARAPGPYEKGARAWTLLVSPQRLTRVSSARLDKGLYLLDADHSKCQQLALLSRSQSSVPLLTLHRCLGHLAPSSIQKMVATGLLEGLGAGYSDKEVEKFVCNACLSAKGHRLPFPDSDSHSSKRLGLVHSDVLSLPERSLTGKQYLVTFLDDYSRKLWAYAIGHKSEVFGVFKTWLAKVELETGATLKVLRTDNGGEYCLRAFTDFCKARGTRRQYSIPRTPQQNGRAERVNRSIVEGVLALLADAHLPKTFWEEAAAYFVYCKNLCQHLALDKETPNSVWQGERANALALHPFGCTAWLTVAPELCSKLDPKAVRVLFTGYDLASKAFRFYDTTTKKIILGRNASFLDTEFPGLHGDSTEQDADTHFASAPIAEPQDTVKTWTPLPQVRLDPPDVHRPDFSTYREPASAEESPDELDLIGRHSRDESPDEIDFLTRHHRAFIATDDDTSDAEAIQPVKSITSDPQTWREAMSSDKREVWARAADDEFNSMRDDFKVFTIEDRSTVPTGATIVTSKFVWKTKRNALGEITGHKARLVAQGNRQRDGIDFNETFAPVARFSSIRSLLALAAANGLHVHQADIDKAYLHGDLDHDIWMMAPRGFDLPSDKVLRLRRLIYGLKQAGQIWNRHIDASLRDLGYTATGTDHCIYSRLDARQRSHYIALYVDDLLMISPDLAKIKRVISGLERRYGVKRLGPAEYILGIQIRRLDDGSIALSQERYIMDVLAQFHFDTTTRGTTVPMTPGLSLTAIPGQGTEQIKSWYLQAIGSLLYISLGTRPDIAFAVSYLARFANNPGSRHWIAVKHVLRYLRATYRDELLYARGETRITGVVGYSDANWGACVDTSVSTMGYVFYIAGSAVSWSSKRQSRVADSTTDAEYLALSHAGKEGIYLSQLLEELHVQPVAPAHIFTDNEAAAAVAHDPVRVSGTRHIRLREHFVRDMVNRGDISLSHVGTSDMVADIFTKALGPKVFSTHCYALGLRTRHPRLGSASHLREGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M5J5</accession>
    <name>A0A2X0M5J5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C006g03969 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C006g03969</name>
        <name evidence="25" type="ORF">BQ5605_C006G03969</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY55114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M5J5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="254"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="517"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGY55114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1142" mass="126249" checksum="538F1696BB6AA326" modified="2018-09-12" version="1">MLKSKHPPTGPCRRCHKKGHWALDCKHQGEQKTTSNSNHDDSVSTASQQPNIGYFASCLFACRHLPDDAFVVDSGATAHMVADWSLFTTYRRTAQTKIGGIAGGITAIGIGDVAFVAKSGHPITLRGVLHMPGLAVNLLSVSRLCDTDRVRLAFTNEGIDIAKDGQAIAQGHRVDERLYLLDADHSKCQHLALLLRSESTVPLLTLHRCLGHLAPSSIQKMIAAGLLDGFGAGYSDKDVEQFVCNACLGSKGHRLPFPDSDSHSSETLGLVHSDVLSFPTPSLTGKRYLVTFLDDHSRKLWAYAIDHKSDVFPTFKTWLAEVELETNARLKILRSDNGGEYRSNAFTEFCKSRGIRRQYSIPYTPQQNGRAERVNLSIVEGVLALLADSRLPATFWDEAAAYFVYCKNRCSHSALAKQTPESAWNGQRTTATALHPFGCAAWLTIAPDLRNKLDPKARRMIFTGYDLASKAFRFLDHSVNKIVLGRNATFLDNDFPGLQDDAPVNLADTERYVVIPTDPPAPAIKTRTPLPQVRFDPPAVHHPDFSTYREPASAEESPDELDLIGRPSHDESPDELAFLIRHHRAFIATDDDVSDAEAIQPVKSITSDPQTWREAMSSDKREVWAKAATDEFNSMRDDFKVFTINDRSTVPAGATIVTSKFVWKTKRNALGDVTGHKARLVAQGNRQRDGIDFNETFAPVARFSSIRSLLALAAANGLHVHQADINKAYLHGDLDHDIWMTAPRGFDLPSDKVLQLRRSIYGLKQAGRIWNQHIDASLRALGYMAMGTDHCVYSRLDDRQSPHYIALYVDDLLMISPDLAEIERVISGLEQRYGVKRLGPAEYILGIQIRRLNDGSIALCQERYIMDVLARFHFDTTTRGATVPMTPGLSLTAIPGQGTEQIRSWYLQAIGSLLYISLGTRPDIAFAVSYLARFANNPGQRHWIAVKHVLRYLRATYRDELLYTRGKTGITGMVGYSDANWGACVDTSVSTMGFVFYIAGSAVSWSSKRQSRVADSTTDAEYLALSHAGKEGIYLSQLLEELHVQSGIPAHICTDNEAAAAVARDPVRASGTQHIRLREHFVRDMVNRGEISLSHVGTSNMVADIFTKAIGPKIFSMHCYALGLRTRHPRLGSASHSRGGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M5L7</accession>
    <name>A0A2X0M5L7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g03986 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g03986</name>
        <name evidence="2" type="ORF">BQ5605_C006G03986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY55202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M5L7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY55202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="124" mass="13561" checksum="2160B5608A20347C" modified="2018-09-12" version="1">MQTSSPDEDCSQLRKLARKEANKAYLNELSACLDDTAQRMALNVRISFAEARAQLLAGLYAENPLRPKRAVSGWNHFVSIASQTALPSQAALEDAGEASDSETEHRSPPARLGYKTITTTVRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M7S8</accession>
    <name>A0A2X0M7S8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C001g00859 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C001g00859</name>
        <name evidence="10" type="ORF">BQ5605_C001G00859</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY50147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0M7S8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01201">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056252">
        <property type="entry name" value="Alfy-like_Arm-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051944">
        <property type="entry name" value="BEACH_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108:SF4">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23295">
        <property type="entry name" value="Arm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0853">WD repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="9">
        <location>
            <begin position="1824"/>
            <end position="1957"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="8">
        <location>
            <begin position="1983"/>
            <end position="2299"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="2443"/>
            <end position="2484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1739"/>
            <end position="1759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY50147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2731" mass="300976" checksum="0918B3C72348ED6C" modified="2018-09-12" version="1">MHHLRRLPSAASFSSMFGGPPPSSDTTPTSPSSEARSRSFSIASSSLADALDNDIHAGLHLNDGEGPSSPIIDEVSVANSEIIAALEALQITQRAGYSERLRLIAKIQHIMIDQPETRNAFREHGGFLNAVSVLASLEERAAAEHHGGVGIDTSEQRHELRYELVKLVFAVLALAFEGHDVNRSTFNDTVGYEAIGEAIKLSGLMEAQIDDKDVASGSSTTVEGLPASPTPAEKLFSILYAFLTADFSSPPIYSYLRRHLNPPSPAETESAPVVFDADAKPVKAVIDLAADAERIVVLLAERADAVRESGGEAAEHPEVVPLMLNLASQLGENEIVLRLAVLSSLLQLIWSSTRSQVALNEVGLVGIALSRLIPSQEQKQDDLSPVERDLWIKLMQRTLEMGSDTHNSRRLFQLAVKGWQGTDEEETLDEEVLELILIGVRRSRFPSFIHFDLSPTGYSALVLPSLGRVFPPATVGYTFMGWISIDVPPRAGDSFSVLGCGDSSGKCHFQLSITSDLQFAVSTSPSKPPVVFTNHWLQLGKFQHVALVHQRPKYVLSSPISLYVDGQLVDTSKIAYPTAPPKDCDVQAWLGTPTERVAEGGLGKGLNRVKWNLGPTWLLHAELPEQMIYVCWTLGPRYAGLFQDQLGQFQTNASSTDLNVRLEIAASNGNAQPATQALIQAIRERGSAVVPDHKIYFAFSALNVLAAGSSRGILGTGLSDRARQALASTAASPRGKAIVNSAIPRKIDDVLLMPNGLGHLTQAHACNPRGLDAAVWKIGGVSVVTKLIELSKTSAQLATTVQLFVECIQDSWRNSEDAERTQAYETLAYLLRHKASLIDARTHDIILSFCGLDVDEPTRSIVSNVLAFRFIILDLVLWGATDLPMQQRHLQRLRDFVQRSEHASFNMRRVVKMHLVRKLLFSLRAGLFYPSMNDEIVDFLMLVVTAHFSTETVRHVATFLTATLCQVVHVSAHPIEPAENIDSPDPEAENPAEAFVLDVRRLDAGSYAASLRVLSALHDLVLGTESTQALAKFAKVITTKWTLLFILDRTAPPLAAVLSLRILVRLLQTQGSAFAAKFANSTDGYQMLRSATPHLWNFGQIHLALFALLHGRDISKVSLDADFSPSVFATCSVDLSPVASEVVRVLVACVARGVMVLERKPAEAVTREFVTPQIGIDKSPALNGGENPKPRLRTRLSLAQGFDVVLALLDQANRATTGSHDHLATSAVALPDLVAALKPALRLVGELEYAPAEHVPSLPIITPRNGYHFVATVRRGSRVSIDSFSSGPAEESAGLGVLGVPLSTSNSSRLEASLASPLWTSVMPDGQWPPIFDDPKTMGPAATSLLDFLSSQVTDAITTRHVKRMSISGFDLPMTSAEPPLQILRDMIDASASSDLRSQATFRTSLLRAIMDRLTRASTATIVANRVANFVEFATEQAFQGWYADIVHLIKFVLSYIEKLLDESALSVPLDAAKPFVQLYKSANRLVLLALADDLEVPETVLNVLVHHQLTLFAGQNAEPEFFRLLVYRLSVLTIASREPAPLVDFFKLLVLQRSGDVEDALGQQRKHDFEPPFSSKAIDTDVEGFVTLLMSSEPQIKELSDFWDGFIAGEVSRLRPILEKDIVRLEELATSLKQKRDAQRKRMRTQRTAIYDWSEGIHEVEATRVAHTRQDFTDHAAYIHAEWIDRSQALYRERGIWGMPLPTDRWQLDFTQGPYRIRKKLQAELPKKIALPPADTLTSNRYRRMGNGSTSRHDSISQSPEITLLKVQAATPVPVSSPGQSNLPAEESMWVEGASMETTMMDSDSPEPVTDEDKNRKVRRSLESGDVIESVFNINRIVGLDAVAGLLLLAKKNVYIIDGFFQTSSGDLVDAWEAPEEERDRHLQTLAELAVQSTASAHEVDIAHRSRRWAWTDLLEVHERKYLFRNVALELFFADGRSFLLTFSKEKRQAAQSGIAARNPGSVATGSLHIVGATLGAKFSDAVLGQKTKLEHITKRWERREMSNFEYLMHLNTISGRTYADLTNYPVFPWVLADYRSDSLDLTDPATFRDLSKPMGAQNPQREAEFAERYQQLQELEDGTKPFHYGTHYSSAMITVGYLIRLRPFTESYLDLQGGFDHADRMFHNLAKAWDSCSRLSHSDVRELIPEFFFLPDFLRNANGLKLGLRQESDAPIDDVALPPWAKNDPRLFIELHRKALESDYVSAHLHLWIDLIWGYKSGTGDDAIKAVNVFHHLSYEGAIGELTPSFRPCDRRTEQVMYPLLDLDSIANVDERRAATSTIHSFGMTPKQLFSKPHPTRIPPLVAKATRPIFSHDNSIEQQYTTLIQSIVPVCDIGQHISAIHPSTTPEKTTATGSHTLAFPGDASHSVSWGYADQAVRVHAKGNNNPTSLFEGMHSEFVSAACFADVRTFVTASTDTNVSLWRWRWKHHQRGEVQFQQVECLRGHSDQVVCLAASRPYSIVVSGSDDKTAIIWDLNRQRVSERGFVSLRLVQHPSNSVCPPLVRACSGRARGARTVGYHRQSMKSSIISDTTGDIATCSGSALRLWTVNGVLMATQSTSNFVDPITAVAFSQHETAPLVATGHRGGRIMLWERVKSDTEPTGWALKLVHTLRHKDRLDARPVPDITCLTFTRRQLYSGDSSGRCYLWSPPGVELFLPDSIGGGSCMGCKQAFGLLETRRRCSSCAGIFCTMCTTTSVEVGGRFCASCFRVLSPLAVVEPAAPLTLTVAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M7X6</accession>
    <name>A0A2X0M7X6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C007g04750 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C007g04750</name>
        <name evidence="5" type="ORF">BQ5605_C007G04750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY62896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M7X6"/>
    <dbReference type="STRING" id="796604.A0A2X0M7X6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="24"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="445"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY62896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="545" mass="59323" checksum="3223DCB6D69A1D79" modified="2018-09-12" version="1">MTIYTSPFPAVEKWSDQGLFDFIFENNDKIQPNNVALVDAGTGTEVTYKQLINDSLKFGHGLSQRYKPGQTMLIFSPNSIIYPSLLFGAQAAAMVATTANSSYTPNELAHQINISDVDLLLVGSNLVDVAKKAVQEAGLKESQIFVLPGVDGKINLQGLESYEVLIGSGKGFKQLKVPDIYAPAYLPFSSGTTGRGKGVAVSTFNITSVSLQLRQVKGLFDGPEVVIGVLPLYHIYGLIVLLHQTLLNGGTIVLLTKFDLPLFLESVQRYKATVALLVPPIALALAKHPIVDKFDLSSLRWIMSGAAPLSADLQTVLERRLKHKTLILQGYGMSETTSVGLLPDISQEVKAGTVGRLLASVEARLVDPQTGKDAKAGEPGELWLRGNNIMKGYHKNEKATAETINKDRWLMTGDVCIRSEDGVYTIVDRTKELIKYKGFQVPPAELEGLLLECPLVADAAVIGVWSEADATEFPRAYIVLDAAQKDDQDLAKKVQKFVDDRVAPHKKLRGGVFLLDVIPKSPSGKILRKDLRTLAAKEGEAQSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M851</accession>
    <name>A0A2X0M851_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C007g04877 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C007g04877</name>
        <name evidence="2" type="ORF">BQ5605_C007G04877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY64163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M851"/>
    <dbReference type="STRING" id="796604.A0A2X0M851"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="707"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="759"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="825"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="856"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="872"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="920"/>
            <end position="938"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY64163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="963" mass="102818" checksum="69A1563EC3891127" modified="2018-09-12" version="1">MASESAPPPPVRRSNSMNLSDLPSTLLERVLALALRVGPGASTSTQPLTCTDAALEQQRSLARTLLYDLRNRRLAQHTKKVLWSTLTLPDDDMLVLHAQMMISAHGGADSIALEGSELATNLVAADVQNIKSVASLYTDATVPQLVRHLHVTRAECLTSSAVESRAIGNNSNSSSQSAPAPPENLLLQRLPPGDELSTSTLRFQPIDDDALLHLVSKLISLSSFEWAAACHPPRMLCSTLGASSKSLTSFKFDLTEAIDSREPTSTSPTTANSPSRAVSTSATNLSAGRIQRWDAPELSALPLSLTHLALSFLSQVGAQELAAALPSLPALDHLELGKSVYIDDPLLAEVGKHVPRLKRLRLYNLPGSKLTEVGLGDVLDGCSTLESLELCCVEGRLSKSTWSKVSPLPESLKTLVLLYHELPSPPHKSWVLDHLSSLAMALEFSSLQSLIISRKVEDVVRIPGQHWTSIHPIDPVLAPRPLPTAFVDAIASRGRAWKDLNLDLWQIDGHALKKVLSACTNLTTLQVMYDESLRNLLGLSSAFAVAHQLRNFVVSIDPAHVPALFPGHPRSPSQSPTSTVCPLPFGSSSETQLTPPRAHQGRRSSVSSTASRISLLPDQLGTNAPSTKDWRRFLKKTLALESVEWTGRGGLGTWFFERTSTLSSSIKVDFEPSAFYAKTLVEVGEGMDLLTGVEGVDPVWRGLMRRSSKVDAPETDDLESRAPLPALDEAGSSGFSTLAKRSLGSSISDGDTVSDHRSSTPPIGTWTSRSHIEHQKAWESSTADHPPTPPSDSPSGLSHLISPSLTPSEGLEMGGSSPVVPPSMKSEDEPKRSWSDFVMNPRVGPVQSRKMTSTKLGEKIPSHKERAQPIRASSSVSKTPSTPASAPKPTLTSSPAPSPTAAKTFSSIVGGGGPTKVVHTRSNTGTGLRGSPRTSQGGVPSARKPARASRGGGPGATQARSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MB04</accession>
    <name>A0A2X0MB04_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C007g04756 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C007g04756</name>
        <name evidence="7" type="ORF">BQ5605_C007G04756</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. PCH2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY62932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MB04"/>
    <dbReference type="STRING" id="796604.A0A2X0MB04"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051598">
        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001494">
        <property type="entry name" value="Pachytene checkpoint component Pch2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044539">
        <property type="entry name" value="Pch2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058249">
        <property type="entry name" value="Pch2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991:SF1">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23242">
        <property type="entry name" value="AAA_lid_TRIP13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23563">
        <property type="entry name" value="TRIP13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0469">Meiosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="356"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="91"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="154"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY62932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="647" mass="72063" checksum="3F5C2312EBA325AE" modified="2018-09-12" version="1">MGSSGFELAITPPRPRQQSKKLSSAASTTAAAAATAAATTAISPLRKGSLNHPPKVLPILPLPQQRSLSPLTHLSTSTRSPSSSTNILHEHTLAHPVPNRTNGLGRTTLFGEPPSFSGSTSAGDMSMVDDDDDDERQRSNQLQDEQLDLEHHDWQQEQEQEQDQDGDLKPDTILDAAQDDSDDDQDQVYKPVLHVEVRLKPTGSVRTDTLRTIVRQYLLADESSTITVEQNCELDSAWTRIAVLDMYVERIWIAESDYPHMTVPLSQVELEIHLYQPALSSRTSDCFISTADDDYENQANEDDGPAASVLELPSLSLEGIWDNLIYEEPVKENLLNYIHSSMEFSDHDVDFNIVSWNRVCLLHGPPGSGKTSLCRALAQKLAIRLSTTYRFGRLIEINSHSLFSKWFSESGKLVQKLFASVTEMVEDEEGFAVVLIDEVESLTAARAGAMSGKEPSDALRSLVFLQVVNALLTQLDKLKTRKNCLVITTSNLSEAIDPAFIDRADIKQYVGLPPPPAIYWILRSSLLELMSKRMIRPQSLLTYDQLSKTRLPSTPEGTRSTPSHRLFDLATECRGMSGRTLRKLPILAHSKFLTKQVLKGRAGSNDRGLKLERWLEALERVVREEKRQKGLIEGAGRKEGFLEGERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MBL1</accession>
    <name>A0A2X0MBL1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C007g04595 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C007g04595</name>
        <name evidence="5" type="ORF">BQ5605_C007G04595</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY61741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MBL1"/>
    <dbReference type="STRING" id="796604.A0A2X0MBL1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF8">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE GSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="22"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="118"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY61741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="280" mass="31498" checksum="7E71F2485A872179" modified="2018-09-12" version="1">MASSSTPNPKARNFVTGPPASSKGIDFYSVDTPNGMKISLAFAELKEAGSDLVVNRHNINFGKNEQKEEWFLKEVNPNGRIPAIVDRDRDNQSVFESGSILLYIAKHYDSTYILHFQDDKYETDMISWIFLQNAGLGPMQGQANHFLSAAPEKIPYAARRFIDETKRLLSVYEEKLVGREYVVGEGQGKYSYADIFSILTQTAFTWIRAAPLVLGASLSESGFPNVEKWVARIADRPASKVSFKPDDFVTKALSGGPEALKKRVEWVYEQKKDEQKKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MCE5</accession>
    <name>A0A2X0MCE5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA repair protein RAD14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C004g02597</name>
        <name evidence="13" type="ORF">BQ5605_C004G02597</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPA family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY65804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MCE5"/>
    <dbReference type="STRING" id="796604.A0A2X0MCE5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000715">
        <property type="term" value="P:nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21077">
        <property type="entry name" value="DBD_Rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.530.10:FF:000003">
        <property type="entry name" value="Dna repair rad14 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.530.10">
        <property type="entry name" value="XPA C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000465">
        <property type="entry name" value="XPA/RAD14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022656">
        <property type="entry name" value="XPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022658">
        <property type="entry name" value="XPA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037129">
        <property type="entry name" value="XPA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00598">
        <property type="entry name" value="rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05181">
        <property type="entry name" value="XPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00753">
        <property type="entry name" value="XPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="XPA C-terminal" evidence="12">
        <location>
            <begin position="209"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="46"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGY65804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="344" mass="39130" checksum="41C66200A326F62B" modified="2018-09-12" version="1">MELSAQDARTIAENRLKAKARVQERERHLVAASSSILNANAKRPLQVVPASSTSPTAPNTRRTHATNPTWGTTTSSNALQQALASGSGDQVGVRHFQGADKNAPLKNMIGNYIEYDLATVKNSKGGFLLENEEDDPRKIRARQMEEALRQKRIENAQKQGQLREPKMALDQQQNPKCRHCGSMDLDTQLRTIFGIFVCAKHKAELPDLYSLLTKTECKEDYLLTDSELRDEELLPHLLRPNPHRPTYSNMMLFLRVQVEEFAFSDKKWGSPEALDAEFEKREAEKVDKKSKKFAQKLQELRKKTKTNVWHKRVEGEHEHQFEEGEGEGVQVCSECGFKVEVETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MDH2</accession>
    <name>A0A2X0MDH2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C005g03261 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C005g03261</name>
        <name evidence="2" type="ORF">BQ5605_C005G03261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY73105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MDH2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY73105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="639" mass="67952" checksum="EC24D6AF66E1896E" modified="2018-09-12" version="1">MAAELVAPMHQQLAAYGARHAKYHIQVAQDVPDDLLFGNFCLNCGNEAPSDSPYCSEECRQHDSEHESAPDSPSVLPALVPSASKSTCSSPSSSATNSPSPRGMVADAVLHEDPPRLDLGAPVTLAKFYGGQSLPIAMRYPTSKSWKASHVDYPAAGPHDVDPKASPQQPASDLHFRRRASKPQIPAPLFYRERAAHVRSSPALGPISPTKPTFWSPQLAPTSDITSLALPPLSSLAASSAALPPPVVRTKNCGRPGCVGEMRRPRISASGKSSSKSSSRAPSNSNNSRRSSASAALQSTNAYDPASSIDILMSPRIRALRAAETGHLASLDDLSPEDSTASQPAPAHPHPADEASGSSSSDDDESSHTHSAFACYLFSHLSEDKKRALNLARDDHADDGDDEVDERVPRGRSGASLPAASERGVSVDSAAIANKNLARPTRFLFSRGTPNPIPVEEELDHERTIRSRQSTVRPKIEPGHFISATTDSPGTSVMPSPFPSTPSSPPTSGRGRSVTRRPSHSETDVLGDLPTGRGRSQLRGPGAVLRSLSPTARGVSESSSRGRRSSSSRARESESRGRESRGRGRSSRNVTDDEALELVDEGDEDERGRGRGRGRDRSSSAFRFREIIISGAAYGHGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MDK6</accession>
    <name>A0A2X0MDK6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C009g05494 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C009g05494</name>
        <name evidence="3" type="ORF">BQ5605_C009G05494</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EXO5 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY81369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MDK6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045145">
        <property type="term" value="F:single-stranded DNA 5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019190">
        <property type="entry name" value="EXOV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14464">
        <property type="entry name" value="EXONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14464:SF4">
        <property type="entry name" value="EXONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09810">
        <property type="entry name" value="Exo5"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="265"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="654"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="294"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="320"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="673"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY81369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="764" mass="85596" checksum="4C5F132CA840E432" modified="2018-09-12" version="1">MFQDGHNDNVTNMINETQDARMDAISDYGDELAWDDEVVASQLDVIESSIGAAPLDATQPTPTPPRDMPTVEIQVENTTDKIPLDPQVNIVIDQAYEQALAEAMDDLNGVHEASDARSLWERYRKRRGWGALSVTDLVAPSWCEYQHTYRLASKSYLPPLERPAEILSKLGATITIDRTRTVAREKILDGGKAVHLKIEKQVMGDVEPVKVDVAGKEEWWALRFLNTIVCLETLVQTGRTREIPVTGFVGEFLVSGVIDEVERREIKSKPAMSEPKTPSKPQIPSSIRTKKAGAKPEVDTSQRKIETFFKSPSSSSKTWPNPPVADPAMPSTPPAENPSSRWGYIMSDTKTRKTPTLPYESESKASRLQLMLYHRLLTSLLLKSTPRSENTPLDPSPSTRGDQAFDWSRLYAHLSLDPNVEFGQAFVRSIEPILGGLSIQEFRPRTLGEVVKGLQYFGEMMSPSNTGKGFLEDCLEINYVMREKGRRWGWKKRERVGRRRRDLKEEDDRVETAIRESLDGVTDTDQREALELERALEMSLEDREGTGVKGLGGIGAREESQVDTKHEVPIVSDVGMLDDTLALSMLEEASKSEDAMAMEVDQGTSIDSGTLGIRTVPLVEVEVGPRYNLRRGRNPSGTLVSEVVEKGKEMVISSLPSSPVPKFSNLTSSNPIEDQDEPDEHLDEGTTIGTHRFKNEPLELDAWLEHVMGYWNGTREAEGVDVRQTNRCRNCEFEDDCEWLKIKSEEALAASRQKRRKLEEGNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MDT6</accession>
    <name>A0A2X0MDT6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C009g05574 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C009g05574</name>
        <name evidence="5" type="ORF">BQ5605_C009G05574</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY82510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MDT6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF6">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016008349" evidence="3">
        <location>
            <begin position="22"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="93"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="434"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY82510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="492" mass="50696" checksum="D588CAFFAD332DB2" modified="2018-09-12" version="1">MLQSSSLLCFAMVGLLGETFASPISFSAKGSISIPLQRRLGFSDLDRRIAQHQALKARYGIPLEDEDVQASRRLLRKRASSASLPIAGTDQTFYGSLTVGTPAFTYEVVLDTGSSDLVMMVPGVDRDDACVGNCVITGQLYPALNGSTSAVALNRTTNLVYGGGIAAGYLVNDTVSMGGFTSVQTIAACNNVTSLTSSSDETGLIGLAFESLSGTGSRPFMQGLYETGQLAEPLFAFAPAPLDLEDVGPYQTTVPGGFLDIGATNSSLFTGSIGYTGLTGGQGKYWEIPLDAFHIQGVDVNISTPNAVIDSGTNSLAIPTLAAEKIFAAIADSKLIAGTGGLYEYPCKTNVSLTLTFNGVQYTTAPKFFNGGVSPGRKETHCIGAVSALGGSSEEALTTYVIGTPFIMNFYSVFRFNPPSVGFAPITNSSALTSGGIPRSNGTTSANVTTTSSSNGASATARSSVSHLSARGSVLGACVGLVVTAGAFVFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0ME30</accession>
    <name>A0A2X0ME30_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C005g03179 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C005g03179</name>
        <name evidence="2" type="ORF">BQ5605_C005G03179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY72524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0ME30"/>
    <dbReference type="STRING" id="796604.A0A2X0ME30"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="918"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="451"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="551"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="713"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="764"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="922"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="961"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="977"/>
            <end position="986"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY72524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1235" mass="133040" checksum="AF0CC5C09E7F1F43" modified="2018-09-12" version="1">MDTPARPDDTDGGASPVAADVVPQDKPASADVESTTAVENLHYEHDCDRDHDPFVDPEHEDVSVLDNCWGDSSTPQPTSSYIPAGSFDDVAPPVPTLDASTSTAQTTTTTTTDELDPPSSHTSLTNGDDPDSDPVESSDLPASASPAPSASLAPLITPEEAAAQVVASREQEHFEAAPVAALEVQIRGDGDDDDEIQIEDSAPSSLVSHPSITTPRPSRTMVAPFGFELELHHGTVGSSPDPLGMTPVASSEIASRQPSRHRSQSYISRLGRADSEPLDRSSASAQATPTAELSPVTTWPHSFTLEVENRPMKRPTPPCPPSTSQEERFCRGNSILAEVPSSSHGDDSESDDELGLAPPPRQASSLASRKGKGVANPKPKLSAKGKGKAVVKARAGTASQSAQTSVRRKSSFSIEVPFHPSPSLATPRSRDAPHADISVTAPSSTQGTEVSLEAASLPSAPASPLPPANNLSADIGSPPVTPSSDLTVLPSSRLGTPEPPVSSEVAPMEVDEIDQLRAPSPPAMESEAALQSQNEAAGTIVSPSSSMPALVSAPAPTAPKTTTPPPSPPKKRVPRALIERQASMQSLATGSTSKKRLEDSDSSDEDMRPPPTSSTTFSKTKRVPRPKLSQSQTGSVKGRESSRVDIPAKRRAPPLAKRKPVQRASSSDGDEEGKENGQHDDESSDLSDLSEYAESPRKQPVNKKRRSDAKPPGTTTIAGQKHGSITSGRAGTQSKIATTSGTQQKSKKERSAEDEDESIKDADSPATTQSPMPSQSQPASTNPLGYVLAQIAPRETEDQRRSNWNVLRLDNLVWTLVEADNGARFWWPADMTSPSKKPPLLLTLLQDDEQTILQLKPTGTITIDDPQPTNILTWRTEGKIRYDKTSFCEPSTIEDAKTPSVTAFESVLMKAWELEQRRAEDEAADEDQDESEEATVKAKSPPGAKASKKGRQSVSSSPRKGTPKRKKNGKKAASKDLDDENGSSDDELLRAEDESVGIDFPAIALGFADRAWWGCQVLDYTPAPSQGRQGHRAKGKFSVEFIDGKFKNLTRKQIILPIQEEFLTVKLGQSVLNVSKNYEQELRQNVDGFKDQMQAIIDEEFPQAKHWNEEYHAGGNRRIRLAKDALLGELTPEHIEAVVDQIKRWAAGENNVRRKGSDRYEALNETDRSRYNADVLLPLVVQLLTIDELDSRDEGKKVLMEEDGVAEPTEAQIEDKAFQLARNHLEKGSIMKTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MFM6</accession>
    <name>A0A2X0MFM6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C008g05132</name>
        <name evidence="10" type="ORF">BQ5605_C008G05132</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MFM6"/>
    <dbReference type="STRING" id="796604.A0A2X0MFM6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000010">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000006">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000003">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000058">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF10">
        <property type="entry name" value="EUKARYOTIC TRANSLATION ELONGATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="17"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY79440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="842" mass="93313" checksum="60F6B54C1C7EA8E1" modified="2018-09-12" version="1">MVNFTVDEIRGLMDKPTNIRNMSVIAHVDHGKSTLTDSLLAKAGIIASAKAGDQRAMDTRQDEQDRGITIKSTAITMFFELPKDDVPDIKQKTDGGEFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIDGVCVQTETVLRQALGERIKPVVVINKVDRALLELQINKEDLYQTFARTIESVNVIISTYNDPALGDCQVYPEAGTVAFGSGLHGWAFTLRQFATRYAKKFGVSKDKLMPKLWGDNYFNPKTKKWSTKAQDADGKPLERGFNMFVLDPIFKIFDAVMNFKKDQIPTLLEKLEIPLTSDEKDLEGKALLKVIMRKFLPAGDSLLEMIVIHLPSPVTAQRYRVETLYEGPMDDECAVAIRDCDKSGPLMLYVSKMVPTSDKGRFYAFGRVFAGVAKAGPKVRIQGPKYVPGKKDDLFVKSIQRTVLMMGRSVDPLEDCPAGNIVGLVGVDQFLLKSGTLTTSETAHNLRVMKFSVSPVVQVAVEVKNANDLPKLVEGLKRLSKSDPCVQTWISETGEHIVAGAGELHLEICLKDLVEDHAGVPLKISDPVVGYRETIQATSSMTALSKSQNKHNRIWMTAQPLDEEVAKAVEDGKIGPRDDFKLRARCLADEYGWDVTDARKIWCFGPDGQGPNFLVDTTKAVQYLSEIKDSCVAAFQWASKEGPMAEEIMRSTRYNIMDVTLHTDAIHRGGGQIIPTCRRVVYASALLADPGLQEPVYMIEVQCPETALGGIYSTLNRKRGHVFSEEQRVGTPMYNVKAYLPVNESFGFTGELRQATAGQAFPQMVFDHWQTMPGKSTEKGGKVESLVLEIRKRKGLKLEIPTLDQYYDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MG07</accession>
    <name>A0A2X0MG07_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C005g03700 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C005g03700</name>
        <name evidence="2" type="ORF">BQ5605_C005G03700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MG07"/>
    <dbReference type="STRING" id="796604.A0A2X0MG07"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="64"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY77698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="390" mass="43545" checksum="954CF7B0BC052BFB" modified="2018-09-12" version="1">MAATAVTKFAVKIIDFEWAFTTRPSPDAPTYWEAMSSKDREMWLLAIKTEKAALAAKGTFSLPLFNLPPGTPIIKSKWVLAIKRDSEGHIEKYKAHLVARGNMQKAGRDYKETFSPTGRAASHQLLLALAVENEWETRQFDVSSAYLNGEMGNVVVHTELPDTLVVRLHKTLYGLCQAGRKWYKVFAGWIASIGFVRTESDHAVFVKSEGARKLFLSIHIDDGLLTGDGDLDGFIQQLKSCFEAKSSDEATFFLGQHILRDGKTGAAIFKVDTDLGFAQSKPTKLHGDNQLAIQLAKHPAFHARTKHIGIHFHFIRDHIAKGMIEMVWIPTNTMAADVLTKGLGSRKHWDFVHAMGLVDALREGASWKERRAVEEVCAAYTRVQEGLNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MGT6</accession>
    <name>A0A2X0MGT6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C017g08549 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C017g08549</name>
        <name evidence="2" type="ORF">BQ5605_C017G08549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY20247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MGT6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY20247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="74" mass="8703" checksum="94FDE1B447F24EBF" modified="2018-09-12" version="1">MERAICHLASPPRHWVSAPRHRNTTGDHATQSSHGSGELFQKAAVITLEARMMRMRMRMRMRLWRKMMRISVDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MGU1</accession>
    <name>A0A2X0MGU1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C008g05101 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C008g05101</name>
        <name evidence="8" type="ORF">BQ5605_C008G05101</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MGU1"/>
    <dbReference type="STRING" id="796604.A0A2X0MGU1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042285">
        <property type="term" value="F:xylosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051292">
        <property type="entry name" value="Xyl/GlcA_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12270:SF52">
        <property type="entry name" value="GLYCOSYLTRANSFERASE-LIKE PROTEIN GNT13-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12270">
        <property type="entry name" value="GLYCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13896">
        <property type="entry name" value="Glyco_transf_49"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY79308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="631" mass="71784" checksum="CB8A1CA5A536CBD0" modified="2018-09-12" version="1">MSPTSLANHRSSGTLKSRTLLHNAPWHRRLVRRLTSSPSRQRKLAILLLLLGAWFLLTNLTHHFFHRAAEPGSDGPSSTTSASKVAIAKGRDRLVQFVPSQQERNKITLHYHDGGEPQTLVFPPPVIPRLKSSRPWNEWTELAWSERGPIRRIEMPFGTRMTFVNSRGLNKTIESNLGDGCEEGSCEGLRRFTVTQDELLALRQLGKFGKFRSVLFRILHLSNLQVFPPHFADSSTRKVVRLPSMFASRLEDITLVTQLSVTRLERFTQTLRIWDAPISLTIYLTEPSDGEILSTFITNLDDELRAAWSKLSLTLVRPSYSTSREALIRRLRYPINELRNHALRLAPTSYLLVLDADFIPSPMMHHHLQVRVPSLMSHGSETVGSPTQSRQALVISAFALAPSVKKIPKSFATLYEMLYAMNPPSAYLTDPNAGHGPSLPSLLFHTTPLAPHPSRTQLRPSPDWSYKVCYEPQWEPYYVLHRNSYPLFEERFSDQGGDKQSQTALLNAMGWEFRVLRDVWVTHVPKGGEGQGGANLDDWPGKKLGRLLDQELGQRERMKKEDMVQDDDEEGRHFNLAAQKDQERYRYFQDFLPEVEKAFGGNWRWPKGCEANEVIKGNRVGRAGSRIVFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MGV4</accession>
    <name>A0A2X0MGV4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="16">1.3.8.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">2-methyl branched chain acyl-CoA dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">2-methylbutyryl-coenzyme A dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="primary">BQ5605_C008g05300</name>
        <name evidence="31" type="ORF">BQ5605_C008G05300</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>(2R)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = ethylacryloyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:65296"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:156439"/>
            <dbReference type="ChEBI" id="CHEBI:156440"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:65297"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>(2S)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48256"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57337"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:88166"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:48257"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43780"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57336"/>
            <dbReference type="ChEBI" id="CHEBI:57337"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:43781"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>2-methylpropanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = 2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:44180"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57338"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62500"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:44181"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>butanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:24004"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:24005"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>hexanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43464"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62077"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:43465"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>valproyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-propylpent-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:65344"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:156457"/>
            <dbReference type="ChEBI" id="CHEBI:156458"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:65345"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 27">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Amino-acid degradation; L-isoleucine degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; mitochondrial fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 27">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.5" evidence="16"/>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY80087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MGV4"/>
    <dbReference type="STRING" id="796604.A0A2X0MGV4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003853">
        <property type="term" value="F:short-chain 2-methyl fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046395">
        <property type="term" value="P:carboxylic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000012">
        <property type="entry name" value="Acyl-CoA dehydrogenase short/branched chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase short/branched chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000001">
        <property type="entry name" value="Acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF1">
        <property type="entry name" value="SHORT_BRANCHED CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016578">
        <property type="entry name" value="HsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8 27" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7 27" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12 27" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="30">
        <location>
            <begin position="47"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="29">
        <location>
            <begin position="162"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="28">
        <location>
            <begin position="270"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00039850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00049552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00051903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="SGY80087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="431" mass="46304" checksum="ADFAB27B21E4372B" modified="2018-09-12" version="1">MFSQVARRSALVARAATASTRRVVPSAARGFATESELPTLSSLYKLTDEEEMLRDAVRKFAEEVVAPKVEAMDEAEKMDPVIIKGLFDQGLMAIETDPELGGAGASFTSAILVIEELAKVDPSVSVLCDVHNTLVNTILRHYATPELREKYLPQLSADKLGSFCLSEPNSGSDAFALKTTAIKSADGSHYVINGSKSWITNSAEAGLFLVFATSDASKGYKGISCFLVEKEMGVEIAKKEKKLGIRASSTCTLNFDNVKVPAANLIGEEGKGYKIAIEILNEGRVGIAGQMVGLAQGAFNKAVPYTFQRQQFGQAVGSFQGMQMQFAEIATEIEAARLLTYNAARLKEEGQPFTKQAAMAKWYASVVAQKASGAAIEWAGGVGFTREVGIEKFWRDSKIGAIYEGTSNIQLLTIGEFGDKRQAGGSSASRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MH07</accession>
    <name>A0A2X0MH07_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C033g11207 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C033g11207</name>
        <name evidence="1" type="ORF">BQ5605_C033G11207</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000066">
        <property type="protein sequence ID" value="SGZ02428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MH07"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ02428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="81" mass="9268" checksum="91D77D49C682919A" modified="2018-09-12" version="1">MHKLRSLDIAHHVTVGVWTSLCSHVVVSAGDPHRVFTEVSYRKWSQLTLRDRNFRERLGRETVWLGAVNVSTAERHGSQMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHL4</accession>
    <name>A0A2X0MHL4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C009g05551 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C009g05551</name>
        <name evidence="2" type="ORF">BQ5605_C009G05551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY82190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHL4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28008">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28008:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY82190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="318" mass="35852" checksum="D85687CB4549A7BF" modified="2018-09-12" version="1">MPSLPTTSPSASRSRTRPRARNSNHRSHWTTTLLDPWRRTLHSLIRVRRSSDLTRLIWKSYSIEPRFPVRIRPMMALLTASSLLVLAALGFHPTLASKISPPVPFSDKLLHFVCLTAASAQFYAIWNVDQAVRTSWHWKHWNELVSILVCGIWGSIGSEFVQSLLPYKTFQWGDVVANILGTTLGITLSRSWTRHREKAQQLRRLYQPLHLEESDDALDDEDDADDGSILASSIAGERMEEEEGTRRESGMGQGMVGGGVDVGGRKGSRKKRSESNPWDDAEDTGSIFGVGFEEEEEGKREGDQGRRSSDEEREEGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHN0</accession>
    <name>A0A2X0MHN0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C011g06317 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C011g06317</name>
        <name evidence="8" type="ORF">BQ5605_C011G06317</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAPT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY11911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHN0"/>
    <dbReference type="STRING" id="796604.A0A2X0MHN0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008010">
        <property type="entry name" value="Tatp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317:SF4">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05346">
        <property type="entry name" value="DUF747"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="475"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="551"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="593"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="666"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="728"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="215"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY11911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="828" mass="92654" checksum="8079CB955ADD768A" modified="2018-09-12" version="1">MPLSLATRSLPDLSQPLQDDENDVGHSEEEDDAEQLYSDPIAPPSPPLPPPPLDHNDRHDDPRDPRDGGASHRSSKYIHSSPKRRPRTHSQSSRTYSSPRSFGSARNHRHDLSLEQPASDGDYAATVGESSSILITTSRPREHDSIPSSTTSFYHDALLDQQQQQDHRRPSLKSYPISTSVHDHFSRSGTPGIDHHDASSIHSAPELEYHNASYKKDDSRIDPSQGDGDGGELSSPRADAPLSPNTSSADRSYGRSQRKGSGSEVFHRLLPYTLWDYLQEEVMSVEVDGEQGVKSERVTNFLTVPGELERIIIFGVIICFDSFLYIFTILPLRTLVAVYTFVINTVFNLHLPLFRRSQPRRRMRLSHKCDIAKAAIFVLAMVALHRITDASKMYHSVRGQDTIKLYVLFNVLEVHHPKTDCDQINPTHLTSLVPFTRQIADRLCCSFGQDLQDSLFSRQTLGRRTDGSHPHIRPLALFGLTVVYVVAHTLVLFYQLVTLNVAINSYSNALLTLLLSNQFVEIKGSVFKKFEKENLFQLTCADVVERFQLGIMLFIIALRNLVELSSTAAIPLFPFLASFPTSLSKLPTPSSLVLLQTIFSPAIVVLMSECFVDWLKHAFITKFNHIRPQVYGRFIDVLCKDLVVGAKGTRREQPFVDQSPVVARRLGFAALPLGCLVVRVIAQAFEMLVDDSAIDECAMPSTNSMNSTGGSVLKGGGVEEGWGDLRGWAVIALVVLIGWICLVALKLLIGINLRSFASERWASMQQREIEDQLNDRGRAKIGVTPAEASMDHQVERLLKDDIFNANERDRKISLASLSRYDMIRSRLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHR2</accession>
    <name>A0A2X0MHR2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C031g10938 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C031g10938</name>
        <name evidence="3" type="ORF">BQ5605_C031G10938</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000068">
        <property type="protein sequence ID" value="SGZ06395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHR2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046921">
        <property type="term" value="F:alpha-(1-&gt;6)-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13132">
        <property type="entry name" value="ALPHA- 1,6 -FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13132:SF29">
        <property type="entry name" value="ALPHA-(1,6)-FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ06395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="573" mass="63972" checksum="D6511A28CB5849A8" modified="2018-09-12" version="1">MVDATRDRGPPCHDDSGDQYELVEEGVRRSVDSGSGDDELTELTMQGIGSPYYASSKKSGLWSGSIRWLLVTVRRWTHSITRTVPNWLESRTGEGPRFAAVPERRSRPKLFYGIVLGLTIALTVQTIRLSATNSSYRAGGASIPLEDMYPASITVRRPPPPMDSSTFAVDDPKDSHIAAWRLSDDASRLPPCGRFILTPFRAGGIGSNMLIMLRGAMFAKKLGITLLVDNSCKWGYGRLEYYFEPYTIDCVPPEDWYDENMTMPVWKPGWRTADRIRFSTDDNTDPIDHELFYERETFELQRVERELFNHTTCPKVLPPSYTLPRPLIPIFEEYAQLLPTLFKPVPAILDDVERVKTMMRIGGEHPTIAVQVRLGDKLEEYGSSTLFINNTFGNLTAHLQVMHGLYDRMVGCSSSQANPCYPLSPTARRFSIEKQPRAILLTIEDDALKQMAHDAIAAPFIFDRTPNVDLAPHYTFVQKDFNDLPLRIRVASARAVIRDLIVAAKEADAAVITMASNLGRLVALFAGESEALLGPKAPAMPQGRAGGRICALDAPWFSTSYLNGIWARVPPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MI42</accession>
    <name>A0A2X0MI42_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C030g10799 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C030g10799</name>
        <name evidence="1" type="ORF">BQ5605_C030G10799</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000069">
        <property type="protein sequence ID" value="SGZ08513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MI42"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ08513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="70" mass="8263" checksum="FE431702BE63F24C" modified="2018-09-12" version="1">MAKPMCLVNLDLVFNNLQTGHLHRSLRTPWSRSLDPRMTRHDRGKLIRQKTIASVERDAHRQFIRPGECR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIW1</accession>
    <name>A0A2X0MIW1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C038g11683 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C038g11683</name>
        <name evidence="3" type="ORF">BQ5605_C038G11683</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000061">
        <property type="protein sequence ID" value="SGY91594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIW1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF463">
        <property type="entry name" value="REVERSE TRANSCRIPTASE TY1_COPIA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="757"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="773"/>
            <end position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY91594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="817" mass="90433" checksum="BFE6E1342D1F9598" modified="2018-09-12" version="1">MTPPRGFDLPSDKVLWLQHSIYGLKQAGRIWNQHINASLCDLGYTATGTNHCIYSRLNDRQRPHYIALYVDDLLMISPDLAKIEHVISGLERRYRVKRLGPAEYILGIQIRRLDDGSIALSQERYIMDVLARFHFDTTTRGTTVPMTPGLSLTAIPGQGTEQIKSWYLQAIGSLLYISLGTRPDIAFAVSYLARFANNPGSRHWIAVKHVLRYLRATYRDELLYARGETRITGVVGYSDANWGACVNTSVSTMGYIFYIAGSAGSWSSKCQSRVADSTTNAEYLALSHAGKEGIYLSQLLEELHVQPVAPAHIFTDNEAAAAVAHDPVRVSGTRHIRLLEHFVRDMVNRGDISLSHVGTSNMVADIFTKALGPKVFSTHCYTLGLCTRHLRLGSASHLHGGGGGGSNAGKEAIYLTQLLSKLHVRPINAAHIFTNNEAAAAHFVRDMVNRGDISLSHVGTANMVADLFTKALGPKIFGTHCYALGLWTRHPRFKPTLRSRGRGCEESTLRSGQDLGNQPFDVAPATVVTLTKEQYNALVKNQRPAQAQEDDAISMHHLLPPVNPPVFPNDSKLTEDNYVDWDLAMLTTYACEVCAYLCKGQHNPSWPPAFHTCWEDYAARALASSLTVTTKATIGPLIQTGGLAHDCWLALAARYAPSDAQAYSMLIKDYFSMPPCPPTWSGFHSWTNRAMVLVNHLQMAQLDLEQAIAARALDDLPPVFDSWLMTFYVVKVQDNKLPCVKQIFASMETVAHTFRHDPTPALTAKPVATTKPITKDKDRRNEPDEGARDEGRGTRDKSREVLGTSQERRGQGTSVRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJN1</accession>
    <name>A0A2X0MJN1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C033g11186 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C033g11186</name>
        <name evidence="1" type="ORF">BQ5605_C033G11186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000066">
        <property type="protein sequence ID" value="SGZ02092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJN1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ02092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="40" mass="4557" checksum="1D08D936F89D6FD4" modified="2018-09-12" version="1">MSQIAFACNRRKNAMPEEIGSKKYSHVTVDNIDVTHHVND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJX6</accession>
    <name>A0A2X0MJX6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptide-methionine (S)-S-oxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C020g09209</name>
        <name evidence="6" type="ORF">BQ5605_C020G09209</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="2"/>
    <dbReference type="EMBL" id="FQNC01000082">
        <property type="protein sequence ID" value="SGZ18881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJX6"/>
    <dbReference type="STRING" id="796604.A0A2X0MJX6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="entry name" value="Peptide methionine sulphoxide reductase MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774:SF1">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE MSRA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptide methionine sulphoxide reductase MsrA" evidence="5">
        <location>
            <begin position="71"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Peptide methionine sulphoxide reductase MsrA" evidence="5">
        <location>
            <begin position="128"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGZ18881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="264" mass="29984" checksum="97B743B3BFC2AB51" modified="2018-09-12" version="1">MAKRHMRQHDAPSAYPWPALPSYLHPPLTPVTFLHFKGLFAAATVHAYTGPTLPTAIQSQRSLSTMSSSETAIFANGCFWGTEHMFRKHFIGQGLKDAKVGYIGGKTSVGRYGHLQKRVYRPRTETAKLKLCFFSSPHKNPSYREVCSGSTQHAEAVKLEFDPSQLSYATLVEFHYRMHDPTQVDRQGPDRGTQYRSAIFTTSDEQAEIAKKVTKEVQEAHFPNDKIATKIEPAGQWWDAETYHQEYLDNNPGGYECPTHRLHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MK12</accession>
    <name>A0A2X0MK12_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C021g09240 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C021g09240</name>
        <name evidence="1" type="ORF">BQ5605_C021G09240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000083">
        <property type="protein sequence ID" value="SGZ20000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MK12"/>
    <dbReference type="STRING" id="796604.A0A2X0MK12"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ20000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="90" mass="10238" checksum="6E6E41CF9F1D12A2" modified="2018-09-12" version="1">MNEIDVEESVPCGIWQLPIYTVDFSTIDRAPRFGGFWLVPPFNVEKVDFSSARAIDRALSIFIFTGNLGFYSKTYPGIGLYPTYDTYIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKA7</accession>
    <name>A0A2X0MKA7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C013g07106 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C013g07106</name>
        <name evidence="2" type="ORF">BQ5605_C013G07106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY14801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MKA7"/>
    <dbReference type="STRING" id="796604.A0A2X0MKA7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048309">
        <property type="term" value="P:endoplasmic reticulum inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000921">
        <property type="term" value="P:septin ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013635">
        <property type="entry name" value="Ice2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31726">
        <property type="entry name" value="PROTEIN ICE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31726:SF2">
        <property type="entry name" value="PROTEIN ICE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08426">
        <property type="entry name" value="ICE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY14801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="395" mass="43715" checksum="A0892652BED8C40F" modified="2018-09-12" version="1">MLCSLFTWYARQCQNGFPGNPPSKTSIALISLLFPTRNATIYLIVRNTSLRPLSTLLSAIVVPLLIPALLLLSLNLYSSDRPTLPKNNILEPLWSVLRLAPAWWEKLLGVSSPIFTIMEGIATLLCIQAVSRFSLRRIAASRTPDVLQLFILVLAALVYVIAAYFLWHSYDSVVDRFNATLIGVEITSILFLSGIGFALQKGTVIETSLVMAYAVFQIFHLANRPAMYSGGLLRDVLQTPGSNGHPPLPPVVLKSLDRISTLATQTFGAGVEFIIAASSALPLPVLVGLFYRVTVLYAASRIILALKRKNEGYEDTRKLSEEDPFPRFMTIVVTYSRLVLIAVYTHLLISSSSTSAQHHATLWRWTNVFLTTGLWALELMIGKAEDMAQGRFKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKS0</accession>
    <name>A0A2X0MKS0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C030g10828 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C030g10828</name>
        <name evidence="1" type="ORF">BQ5605_C030G10828</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000069">
        <property type="protein sequence ID" value="SGZ08963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MKS0"/>
    <dbReference type="STRING" id="796604.A0A2X0MKS0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ08963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="57" mass="6638" checksum="6C12DBE9CBCD6506" modified="2018-09-12" version="1">MTKRTRKSEKKVGAYELVDDHDTQPQKALESWIDPTFEPLAYALILFRDEIPKSAQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLF9</accession>
    <name>A0A2X0MLF9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BQ5605_C023g09726 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C023g09726</name>
        <name evidence="12" type="ORF">BQ5605_C023G09726</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ24467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MLF9"/>
    <dbReference type="STRING" id="796604.A0A2X0MLF9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15874">
        <property type="entry name" value="R-SNARE_Snc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000004">
        <property type="entry name" value="Vesicle-associated membrane protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016444">
        <property type="entry name" value="Synaptobrevin/VAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45701">
        <property type="entry name" value="SYNAPTOBREVIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016160603" evidence="10">
        <location>
            <begin position="27"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="55"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGZ24467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="143" mass="15568" checksum="A6086B4AE1B0AA10" modified="2018-09-12" version="1">MFPIMVISRRIVVLILACHWCNRSDPYDPYISISGAGGNSSHNPAGTPAASGSSKTAAIQAQIDDTVGIMRENITKVAERGERLDALQDKTDNLAQSAQGFRKGANRVRKQMWWKDMKMRLLIGVGIAVLVVVIVANSSKTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MMB6</accession>
    <name>A0A2X0MMB6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g01967 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C003g01967</name>
        <name evidence="1" type="ORF">BQ5605_C003G01967</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY38152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MMB6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY38152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="153" mass="17562" checksum="BB2649EB180F2769" modified="2018-09-12" version="1">MAREREVWFKLILRFTPTRKLQHQQNDDTSPACLVCEAPVDDTNHYFFGCVDSQNVWIAARGVLCDALGCDTIEENQYTTLQQLFGLPKLKAKLSEQEGAGRTIEIFTGMVLEMISSGRWRMQKHRTRMESVERRRVVLEERMKLRAGGARGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MMH1</accession>
    <name>A0A2X0MMH1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C003g02007 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C003g02007</name>
        <name evidence="25" type="ORF">BQ5605_C003G02007</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY38360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="349"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="1007"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1247"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1350"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="2032"/>
            <end position="2146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="1256"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="2096"/>
            <end position="2112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="2133"/>
            <end position="2144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGY38360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2714" mass="297391" checksum="7E43B59BE1306054" modified="2018-09-12" version="1">MSDAGASAPEAKLREPTPDAPPLRPPTHSAAFATTELLRNSSGYRDWVLAIRSRLPSGVVRYLNTGVPLESWPASYVPLWDHYACSSICASVDSQTVLPGLSPYLDDSLAAPKVWQALRERYSTVSAVDLLPVIQRLFSSDPVPVTPDLFLQFRNSFENDARLLQDSQVTVNALLASHLLARLPSSFDAWRTTFVADQGDSTAMPSATEIFTRLYRDVKARPVDTPVAAVATPQARHGCSRPCPNPSCRKLHWLRECPDTAWAAAYRARRTAEKKASQPVASPTPCTPKALLAIPANVSLLTLHRRLAHLPVAQIKNIVQSGLVTGVDWVYKDQELRDFYCNACLASKAHALPFARSKSIASGRLDLLHVDVAQMPRPTFGGHRYMLVIIDDFSRKHWCILLALKSDVFPRLRDWILEVENATGNKVKTIRSDNGGEFTLRNFVDFCTSKGIRRELTIPYTPQQNGRVKRSNRTIKEGILALLYSSGADSRLWGEAALYYVHCKNLMPHAGIGGEIPDTRWHGFVLRTPLLQSPLDYELIGLPLPPTRSAHRCSISTGYEPNVAAQPTRVIKSSCPVIRTLWYQGEQPLSSMSNPAISTRHATCATREAGRNGSTTSKPNARTDLEHANFQAIALLRRSVSLNIKKQIKDGFDHTPTDVLKMIKKAVAAGTVTDIFIKLQALLDAGPPPSGVDAFEKYQANTIELFNTLSGYNLTFDQVISIRLIHFGKDLYKEYYTQALRQDLDKLPDPIEALQTLQTQAESTPAHKPVAMVASLTATDRSSSTPSALCRHCGGPHWNRKCPVKDKKSKASSAPSASLAAAPDISTLVDGPVRGYLTAAMSTLAKPSLILDSGATHHIVNDRACFTNFRKCKPAPLEGITGEAVNSIEGVGSAVVRSFDGSIGQLHHALFVPSAPVSLFSASRANAAGYDINLSRGKATVSVDGSICHTGEITNGLYHMHASLVDVTTLIEQPVNMEVALNEDLKCDTCQAGKITHHPFPTVASNRSAQPLDRVHMDLLAFDGAVSLGGAKYALVIVDDYTRYLWAIPMSHKSDTFAAFKSWLAKVERSSSRKLLAVRSDNGGEFLSNEFSSFLEEQGITRQLSIPDTPQQNGVAERANRSITEGVRSMLHQSGLSHALWAEALATYVYVKNRSPHSANSGVTPHTRWHGSKPSAGHLRVFGCRAWKAATTEARSKLDPRGIPLVFVGYDLESKGYRLFDPATRQVFKSRSVTFFEDEFPARREGITAAHAPVAGDDDDDDDDDDEVVVLPDQHANQAPPDQAELPAALRFDAPGPAWQPPVGSRPRNPPARYGALASLRSTPSAFAFSLGKEVTELVADLEAAGIDTSKANRPLSEPEDPFSLPSSDPTTWNEAMRHPHAAAWKAGAIEEFRSMKDDLKVFSVVELSSVPKGATILPSRHVFRTKRDKAGKMVSLKNHIVAQGCAQGPNSFNNTFSPTAKYTSIRTLIAHSASKGHHIIQADVDKAYLHSVLEEEIYMRVPTGIEGYEGKCLRLHRSIYGLKQAGRVWNDTINATLASLGYRRLACDECIYRHEDAGGDHYIALYVDDLLFFGPDLGEIDRVLDQLDTLYGVKRLGPAEWVLGVQVVRHDDGGISLLQRQYLLDVLARFNMSDCNPCKSPMEANLQLSPEPDTDSADNAIYRSMIGSLMYAVVATRPDLAHSVGYLSRFVGKAGNTHLEAAKRVLRYIKGSLDLGIHYTRTSAPLLGYEGYSDSDWGSDIQTSRSTMGYLFKLAGGAISWSSRLQPRVACSSTEAEYLGLSHAAKEAVFLRSLLTELGLDTSSPLRLLGDNQGAIALTQNPVFHARTKHLRMLEHFVREHVRNGEISVTYIPTHDMVADIFTKPLPRVVFQRHCDAIGLRRISGQEQGGVCEELLYCNLHLITNSLACHCRQLVQHIAVRFLHFAPDISTLRAFGCRAWHHLPSAKRTDLDPKAVPLLFVGFDQHAKAFRLFEPSTRRIQLSRNVVFRESEFPALRPATDVRAEPIPLPVTVDAYPDQVDPLEPSLVASPRSLAPRAEPPRPVPAAPDQGPHRPAPDQGPHRPAPACEVPDQDSLAPPAPDQGSPARELPDPESPASSASDQGSSDSAISTPCPSPRPVASRALPAPPSPARSDSPDPIDLLPRPRDVASLCQAQEFPDDVDDALHSPSAVAYLASGAAALIETSPADPAELIAPARDPPHWRAAMATPQADEWRLAARDEFGSLLRDFSAFTPIDESLVPADAKVLGSRFVFRTKRDQHGQVKSYKGRLVARGDSQRSGIDFDETFAPVAKFTSIRALLALAAAHGYHVHQADIDKAYLHGKLDAPLYIRVPDGIYMPGKVLQLHRSLYGLRQAGRIWNNEIDSALSALGYVATESDHCVYVRTTGDVHHYIALYVDNLLMISPSLPEIERTLQGLEQRYGVKRLGEAEYVLGIQIRRSPDGSISLSQEQYLKDVLARFGMSDAHPVATPMQPDLRLEVELQPTPFPDRTRYLQAIGSLMYASTGTRPDLAYTVGYLARFSHSPSAAAWGAVKHAFRYLAGTLSHGLRYARGNPAPLLGYSDCNWGACVLSSKSTMGYTFVYAGAAVSWSSRLQSRVADSTCDAEYLALSHAGKEAIFLHQLFGELGLSSSKPVLIYGDNQGANALTKNPVFHARTRHIRLREHFVRDMVSMGDTVVQYINTGEMTADIFTKALSRDLFARHRGRLGICAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MMM3</accession>
    <name>A0A2X0MMM3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C029g10690 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C029g10690</name>
        <name evidence="1" type="ORF">BQ5605_C029G10690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ15649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MMM3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ15649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="568" mass="62544" checksum="76B6F957E49E9A8B" modified="2018-09-12" version="1">MYQHTVVSAAPACGVHVPIRSHVQALCAPKLCLTREARAGVCHVMRCAGGWHSFKNKPSLLCPGPKVARDSGRAIATSPSLGREGSAVPWAAMGLLERPLLGAPRLDPPLRPAPINRISPPRVMTTMQPILALRHVYEPAVQLCRTDSVVSAMANSTLGSPHHHLRKGEHFGACCSQGKVRLPPPPQPNLEYRQLLQGSDSEAKAFRENARSYNNALSFTSLAALWDQTQVGTLGPPVFRVFGRLYHRLGALIPAVTQRPTFAQTWLIDPAEATDTRLGPDGADSRMQRSTLTKLESILRTGNRFVREFASAKARAGWDTAKEWILRLCLPPGRDRRTHNLPTSSTEIAMLICDSDTNMVDPRSIRLRCLSGSHYYFLQGKMASTSTFLFAGFAKLGCQSPETESRSTMVSNRARYLRVSVLMTEAKRRTKTATMRMKTARKGTKRMVMANDEGQVKGSRWRVSRSPFFAHYLPNATSTSQSRIAPNVPSWRCDGVCCQRGKASAADDDDVRPRLTGNQGCTGADSACNRPDLIARVFEAKSGNKRHAGCFGDECKMNRFCFFAVLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MN39</accession>
    <name>A0A2X0MN39_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C029g10661 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C029g10661</name>
        <name evidence="2" type="ORF">BQ5605_C029G10661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ15314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MN39"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47481">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47481:SF22">
        <property type="entry name" value="RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="1">
        <location>
            <begin position="392"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ15314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="656" mass="71665" checksum="A82C0241DB00793A" modified="2018-09-12" version="1">MSSTGESDFPNGSGNRLYLKDTQGYKSWSQRAFINLRADKVWDVVNQSIDSLVADYRSTLVIAHATASVAPVEPASSGFSGLGGGGSGSAHSDASPRLTSVQVADKVAEYRERAIRRNDLACKYIANSISEEQMSHLIHLTSAYEMWDTLRGLHSHGRPSRTMDLLNTLAQPYSGDIPFKEFVNKVKIAMTDFQNLGAPLPHWLFAGMLVRSLPAQYDSIVGNLASPPTSSHTGLGATKRACLQTANAEAELRGMLVRSLPAQYDSIIGNLASDIDIHMDWNTFYPKLLMNVKMADSRNKQKESLSARIVDDTSLVARISTTAQKDYSKSYCSRCKALGHERGWRLCPSRNKDASAPASSDSNSNVAAIGVDESALMTYTFPYSQTMPRFPWIIDSGAKVHCVGDKSVLSDVVSEPLKISVADQSQIKSPGHGSVTFLTSYGARITIKRVYYMPGAQCGFISIDRLLESMTYAVGPQSNLIFSICGKSILRSLPGRGFVMDTAPVQPIMSSSPPSMVGANRLTGTCTLMEAHRKLGHQSPAAIVLAVKSGAITGITLKDKKVTPCFSCIQAKSKRSPFSNKSTKAPHALYRVFIDLGFVEHPNHHGDTIYLAIVDQYLTAKWTIVLRDKRAEMIIKAWSKFQAESERQTGQIGQWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MN85</accession>
    <name>A0A2X0MN85_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C020g09216 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C020g09216</name>
        <name evidence="5" type="ORF">BQ5605_C020G09216</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000082">
        <property type="protein sequence ID" value="SGZ18978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MN85"/>
    <dbReference type="STRING" id="796604.A0A2X0MN85"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040200">
        <property type="entry name" value="Mug57-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28156">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN YDR262W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28156:SF1">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN YDR262W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016088396" evidence="3">
        <location>
            <begin position="23"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="4">
        <location>
            <begin position="72"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGZ18978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="264" mass="29200" checksum="62C55DDB30478A38" modified="2018-09-12" version="1">MKPAIRPILLLALSSVVAYSWATSIPQQQHPFAPPTAGDSHSHSHSQLGPAMTIPKTNPFLSSSTNAVSSTTMALADLLTQSRRTSIFYDYCRDVPSVSALLNAPPSSSKETLPTLLVPLNSAIIAMAHKPHQTQPTTDSRFHQLRTERQLEDESNAYLSRWVRAHVIPAEVEMGSEGWQDKTYETLDHSSVQFALRKDETTNEERVVIMPGEIEVVGMSQPDPAKRGQRTSRYRHSDIRICSQTQASNGMIYYIDGTLNLGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQ27</accession>
    <name>A0A2X0MQ27_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C016g08089 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C016g08089</name>
        <name evidence="2" type="ORF">BQ5605_C016G08089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY20545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQ27"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY20545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="382" mass="41483" checksum="689A9373B1BE4225" modified="2018-09-12" version="1">MPPKASTSTLAPIKSTSEPEPEPEPDLISFQLDLDESLAFAQALVRSWVPSKVDTEWAITTNEEKGTSFNSLGHQLTTNRSNRSGRLGLGASANLLNQQQAQDQKLRNQLLRHVGTHSQPQDDVDEKGTMGNRSAVVTNDEDGEEEEDSRSAAIRSRDLRSSKVSDRSTRTTDKKIVQTTTVSSPSTSTTIKPFLTSGASVETSPIPSTSFYDNHTTSLNVASTSTLTTSTTAKSAPPDGNGAKLTKNQRKKERDREKARLLKLQAMRDSQRAEEEKGIEKKRRIGDVEDAMEEGIAEGKKKTKVEKASPVKNGKGPEGDEESSSEGEEDDDDDDEGPSGNGEGSTNGGTKNKKKKKQRRKKKKGGPSPSFKKGEGVLNLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQH2</accession>
    <name>A0A2X0MQH2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C042g12046 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C042g12046</name>
        <name evidence="8" type="ORF">BQ5605_C042G12046</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000116">
        <property type="protein sequence ID" value="SGZ31929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MQH2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001039">
        <property type="entry name" value="ATP-dependent RNA helicase DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052431">
        <property type="entry name" value="SKI2_subfamily_helicases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059032">
        <property type="entry name" value="WHD_DDX60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533">
        <property type="entry name" value="DEAD/H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533:SF4">
        <property type="entry name" value="DEAD_H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26076">
        <property type="entry name" value="WHD_DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="881"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="1314"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="595"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="780"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1279"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1787"/>
            <end position="1830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="614"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="785"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1289"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1788"/>
            <end position="1800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGZ31929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1861" mass="206217" checksum="3D2AB94BFE116A10" modified="2018-09-12" version="1">MDQRAMSDSSVAPSATPPQNEDESTMPRRALTAKDALLELDSGPSGPGPRPNTLPSSDDQATNSWLICPTLDPITCSDWLSTLRPGFWDLVTYAGQEHFVIEGDALLQYVFDQPLLKLGRASDPSHQLLHATWLLEHTLQELHQRDCAFDIVFFESQAHASLYTGHPDQGLVEARRFARQVLKRRARVPEVEVFEFANLLGDDWLQWYHHKRVRSCPFTVPIMPLDSMLIPSFLLKQPMFMLSYDGGLVRQPLAPLEYERILIQRSFIYTVIQQQIPVFQLQTALFQDSKIMSFLYRSGAGQHLSISLLRAAEESYSRLIEATPAPAQVELPSSSTTADILASAAKAVLVHDDPITKALLYVFVAHCYVIQTISLEARAQRIPTPSTDLASTISSFYGTLFAALAGAVQRIPLDDSLSSFDVDGRLFLSLLIEVLTSTSEVSDLLGPKVAADTETLWSRLGQSGVDLARLRSKFSNESTELSPLKEAKTTKLLPYSNPSFDKHFTSVHVSESDAKSPASIAHKLDPDSAFDDTAFWENPKPVLPTHLSGAAPPVLDARQKKKRDRKNQNFMAAMQKSAASLTGALGAQLKREAIPAVSKRAKDRSLAKPSANQASRNPSASKKAPAAKPLTSKEKLLAENAAKKQLEEGVQNALWWNERLEQLKPLNTTAQIALLVGYLKNRRASDRWLGTEMVLKRVDLELRKWIADERRSEPKNADEYRVFIAKTVTPLLERAVEGSATINERQGKALTTTLQVMGLGCMVPEGIQFGAAVEKALEAAAPAAKGDKKGATAGAKDKKEDAKKKSGSSGKAGKEDKEDKGARLSFSFCIKKSSDFDFMKIEEDPLEWQLRCMGEFMRRELDSRPDPRVNFNPDAWQRDVLDKIDADESILIIAPTSSGKTFISFAAMERVLRESDDGVCVYVAPSKALVNQVAAETFARFSKEVAGSSMWAIHTGDYRINNPQNCQILVTVPHVFSEMLLNPALARVWTPRIRRVIVDEIHAIAGEEGGMWEQVLLMNPAPIIGLSATVGAPERFSAWLESVETACGRSYSLVQHQHRFNALRKFTFAPKFPLKSISPLNDHKVKADTFVPIHPIAALALGNPNLPEDLALEPRDTLSLWQAMTKVAQLDPGLEPNKFFAKTPSIAIRDVISYEKELKKVLVSWREAPDSNDPDSPFQKLIFAIESPLRAATDEAEQEIAEHEEDEDFLPSLFLPMLADLNAQGSLPAIIFSFSRDTVERIGRKILEDLEAAETKWRQSSPTYRLRVAKAKEDEKMAAKKAKAVEAASRNKKDEDNEREAADTESQNQFDPDAPSEEFSFVGKGISQVEFKREIDSLAWLDLPSWMMNALRRGVGIHHTGLTRRYRVLVENLYRRGVLRVVISTESLALGINAPARTAIFGGDSVFLNALTFRQCSGRAGRRGFDTLGEVLFVGITLDRIERLLLSKLPKLAGTFPLTTTLVLRLHNLLWGSDYAPLPTQSLDTLLTIPRLSVSDKTDGRSHVRHFTRFADEYLRRAGLIDETGRPLLMYGIASGLYADEPSNFAFVALLRSGELHRITDTFETDPDNTARELLLVLAHIFAPIYRRRIDPRAMRSGARNSSSLMALPPLPKRIAAVLQNHHDAIVTIFSTYAKEYSEQHSNELGADDKLPVSGRQIVPTDPSADGLFASKLRQSKIPFESRSAFTALSGHGDVYDSIEELSGTVRAGVSLQRNAVPALASAMLDSTEHQLDAYAVDFFRHGSLDVLVRDNGISRSFVWYALKDFDTALTTVKTTIETLLQRSSVATDDDGADSDDDNGGFEWKGRSNATTTTTAGEEEGQSSEAEITRPAGVSDADWRLYRAVTHLHVAFNEKFHSVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQJ1</accession>
    <name>A0A2X0MQJ1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C016g08259 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C016g08259</name>
        <name evidence="3" type="ORF">BQ5605_C016G08259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY21633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQJ1"/>
    <dbReference type="STRING" id="796604.A0A2X0MQJ1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019434">
        <property type="entry name" value="DUF2423"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28219">
        <property type="entry name" value="UPF0642 PROTEIN YBL028C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28219:SF1">
        <property type="entry name" value="UPF0642 PROTEIN YBL028C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10338">
        <property type="entry name" value="YBL028C_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2423" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY21633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="154" mass="17578" checksum="CB5CF28EE1C7FBB8" modified="2018-09-12" version="1">MAKSLKSKSKRAFRAIKRTDPNSVFKQADDLRLQRLSAKLKASALKPRERTDKEEWERKQDGYETEEDGEGEQATSKDAKTEDKAVDEMAVDGEQAETSEPATKQKISTSGPRMTRREVFRTEKNFMVRPTPKTVFPARGEKKRTGLGRSRSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MRB6</accession>
    <name>A0A2X0MRB6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">BQ5605_C001g00622 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C001g00622</name>
        <name evidence="13" type="ORF">BQ5605_C001G00622</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Transport of phosphate groups from the cytosol to the mitochondrial matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY48172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MRB6"/>
    <dbReference type="STRING" id="796604.A0A2X0MRB6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035434">
        <property type="term" value="P:copper ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000076">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000131">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="41"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="139"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="240"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGY48172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="336" mass="36033" checksum="89C916B2F0AB80AA" modified="2018-09-12" version="1">MLHALQSAENKLAAAKSAVATEAQKISAKVDSGKIELYSGKYYYTCALGGAVACGATHALVTPLDLVKCRKQVDKNLYKSNMDGWSKIMKTEGGFKGLYTGVGPTLLGYSMQGAAKYGFYEYFKKTYADMAGPENAVKYKDAIYLAGSASAEFFADIALVPMETVKVRMQTTFPPFASGALNGVNKVVASEGAGALFKSLPSLWSRQIPYTMMKFWSFEGFVQAIYARIPKPRSECTKLEQLGVSATAGYAAGVFCAIVSHPADTMVSKLNAPLAPGAAKPTVGTIYKDIGFRNLWGGLGTRIIMIGTLTALQWLIYDTFKVTMGLPTTGAAEPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MRJ1</accession>
    <name>A0A2X0MRJ1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C075g12919</name>
        <name evidence="3" type="ORF">BQ5605_C075G12919</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="FQNC01000128">
        <property type="protein sequence ID" value="SGZ34789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MRJ1"/>
    <dbReference type="STRING" id="796604.A0A2X0MRJ1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ34789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="272" mass="30427" checksum="63CA4F61EF39D964" modified="2018-09-12" version="1">MTYSRGDQAIAVASSGVAALLLKGGHTAHSTFRIPLDTLPTSTCPVDRESDLALMLRTTKLIIWDEAPMAHRFAVEAVDRLLRDLREAEEHFGGVTMIFAGDFRQCLPVVPKGTPGQIVDASLIKADFWRDVRVLRLTENMRLSSNADAMDEAQLARTRDFTEWLLTVGDGTANMHPYDKIALPDYLLLPDGQRTAEGLINFVYPGLRTVNKESLEDLIQLFSRQAILAPHNARVDRINAKLLEEFNGDYIEYRSADEVVEAGETGVEWRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MRS0</accession>
    <name>A0A2X0MRS0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C027g10306 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C027g10306</name>
        <name evidence="3" type="ORF">BQ5605_C027G10306</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MRS0"/>
    <dbReference type="STRING" id="796604.A0A2X0MRS0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="432"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ28299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="680" mass="76560" checksum="9FA6989972D8B75A" modified="2018-09-12" version="1">MANAAASPSPFEARQRVNASSARAPSTPTRAPTDHDKTQPGRTRQARYDYGLLGMSGLDEAVYTIEPAQVESRRVAAEEMERQLFAQMDKPRISKAMDKYFLGTPSKYETKITKPTRRLWTEGALKEFLAEAIRDVTGDRRLVRCDNSGSYIAEQAKTPDAVILTHAAVTASPDLQLVWAQSQDPTPTESRPPAPRRAYSLTSVAIEVKESDTMSAEARKQMVGRLHMIRTTAHRAHAIGVTLCGDLLQVYLVNASGAFTTNARKCGEEAVLLRRVLSRLIELDDDDDDGLGMLASLNEVDDVLGTFVVSDKLLPPRAHDFESELGDLRDLEIQEFLTRRRICRRLTTSACYAIARHAPVDPTAITPITSTSPTPAVEYAITFVWAEHSLLDDGIALHRKMHAASRADTEGLSLSAGIYRGDLRTLPTFLGVDENFDGIEPRALEVVFIRQSYWPLSTTRTTKELAQAVLGVVKGLRNLYKLGYIHGDISYDSVVIDRDGVGALLDYHLAVPHDRPCTELYRRIRYDAWPYLPCSILAEPQQPLRVDHERWHDIESLFYLVMEISFREPYMGDYQVLVMTPDGETFWEDWNEPSARMVYVFKELLRLNHRYHKLLKGCAQRWTNIKQLVDILRSNYGLDNRFIGLEVAMEEDQLGKLWGPSGTMSHEAIISEIERLLPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MSR7</accession>
    <name>A0A2X0MSR7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C047g12333 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C047g12333</name>
        <name evidence="2" type="ORF">BQ5605_C047G12333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000113">
        <property type="protein sequence ID" value="SGZ31202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MSR7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ31202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="432" mass="49059" checksum="9B20BC1F0FFA2656" modified="2018-09-12" version="1">MSQPLANHAMGPSDYLQPYDLQADDNHDPRGQLTDSHITSISRAVAPTASVSTATPEQSLALTPAKRALAEELYEEAHCAPKRHINKDERLQHEKWAMQRLAEEFHYCIKNKIRPQQLRSLTSPTTRLTTSTNPWNDFVKSRYFESRVTNNGDEVPKDLILRQKVARTYWREICSDNAEKAACLAAMAMEQAESDQADSDRPTRHARLESANLRMIRKARMRLQASLSTLATTFSQQYGIEMYAIASSNLPETSKERFIVASPGGQAFMGRRKRANEDWRQAQLMDFTDAVTGQAFLEETRANAVNAAWTESLDDKNLATKTKWYSAILKDLFDAALVRRSKRQGKDIETHRFVYNTAMLKDKARIIVRLGQHLLHDDFRSPTGKRKFSVKDLDRIIPLLRAGELSFDLEEELPGARANTENSDSDRSDEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MTZ6</accession>
    <name>A0A2X0MTZ6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C043g12091 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C043g12091</name>
        <name evidence="1" type="ORF">BQ5605_C043G12091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000117">
        <property type="protein sequence ID" value="SGZ32141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MTZ6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ32141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="63" mass="7190" checksum="037BC406DE1CC6DB" modified="2018-09-12" version="1">MTVWALEVRFSNFGVRFYNLGGRLPMVQDQGSDCARFASFTKGGRPIEKVCTPETSLMRWTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MU05</accession>
    <name>A0A2X0MU05_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C043g12101 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C043g12101</name>
        <name evidence="6" type="ORF">BQ5605_C043G12101</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000117">
        <property type="protein sequence ID" value="SGZ32171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MU05"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF363">
        <property type="entry name" value="PROTEIN SON OF SEVENLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="515"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="1213"/>
            <end position="1511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="54"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="257"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="418"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="693"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="844"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="880"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="970"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1058"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1180"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="445"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="488"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="708"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="883"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1058"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1180"/>
            <end position="1194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGZ32171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1538" mass="167998" checksum="B60E684858DF53B6" modified="2018-09-12" version="1">MARTEHDLGVALDGSFVETTSRSAARALAQHYASQDGGQTVYYVQARVEPNGKTIYRIRPRSQPTPALASTSEASSGSATASTSQVPAKCSASSEAPAPMIALHTPSPRKPTPRSGPTQRLERYPRQTASDNEGLSPYFKSSTVMALQRSGSQPTLGAARSQSHGWKSTTIRTAAREQSDVLGRILGWSTSGTAHLGFTPGTETRSNVNDEDKSDLPQDCKWRSALVISRHGECQLSDLIRCRAWLVPVVDELEGRAPPATPQYREPSPSSSTPFGAGVRLAEGSLHPRSPASDTASPLPVLLLADPPRRREMREVASSDSIRTAKAVDDRLPMPSPHQSRYKDWTAYDLLQNLDTLDHHSLPREPIFRFGRHPAASSASVGSSASDISRTTGQDITVLSTPGDDPRFVIWGVKDQRGHARVASKPSEDSRVNVASSDGGQRRGSIAPAPAVASPVMSSPATASSSSRWSLSQPHHQSESPGTSVRDSVGSQSSIQSPLSSSMTGRSAPGSFAPPQRVLMAATVERLVAELTSKIEVELLASFFLTYRTYLQPVHLLQAFTTRFDWAMQPPSSPADDAARRIVRVRTFVVIRYWLLNHFVLDFYPDRELRTTLTVWLNKRGRDEAIRNNPKDQRLIKGLKKLVRRLKDMHAVLGPTDTIEARAAIARQSTDLPPMPKSPALSDEDVDLDVVPAMGSGPTAPKEFGGAPRDRSRLPTSSAKDKLTTRPTSLIPLPGGQSAVARSINNALGTIGRFKRMLGNRAHVAQASSSSLNPSASAEAVEVVEYEQHDTGDLLWIKDGLDRYLDFYNIPRDVADPEDISSGEVQSQHVELGSLQPVAELEGDQLDASESDQAPSVTAPHESLPVESAPATHVIGCAGPYESASQDRWPSSVSSTDPDFPHKPPNTLFFPPSSIPIFEPASYNEYDSSRSGCLELDDVDLSDEDDDVVEVKRTLKRLPGAANLRLATSVPRKPTAHHRLSTETVSSYGSPCRPSFEGHDRESMMVSWVDDEVSGAEPGVLPGLEGFLLDGLVESDEEEPGDIEAALRRLEGIVDDSRERKKAERVEEQMVKSERKKQGLPWLATASQDGASANGEPRDSVSTSASFSVSVEQPVSPTSTNLEACEIAIVASDVVSLNSSNPSQPYDDHPVAASPNRTVSRQLRAVPRKASIGNLLARTPARASTRAAAGPRGPQASAGPAPPRHRSFLLHCRTELIAQQFYLIERDMLRVLAWPELVSGAWRDRSQPQIEVLDWEAHLKERRRVEILAKESGESKSSSAVQAVIARFNLTANWVASEILLTANPDERVALIAKFIRLAFKCYCQSNFQTLTQIIHGLQLHDVERLNKTWARVPSWEMRKFRGMQVFVSHLKNFKHLREVTKALISEYGPPGQRRPLSANDPYRSVKGTKGAPVPLGCIPFLGLFLRDLTMNAELPTFLDPSSTDTPAEVDAEGTLVSLADPNAFNSLAPLPPSLRMRPLVNVHKFRVQARIVQDVLAAMEFAESYPYDPDARWYLKCLKLRALSSDVMSELTRRLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N0C8</accession>
    <name>A0A2X0N0C8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C006g04150 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C006g04150</name>
        <name evidence="4" type="ORF">BQ5605_C006G04150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY56604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N0C8"/>
    <dbReference type="STRING" id="796604.A0A2X0N0C8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016039780" evidence="3">
        <location>
            <begin position="29"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY56604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="321" mass="33059" checksum="C1A7BDE1330BB51E" modified="2018-09-12" version="1">MLRSGKAIVTALWWAALALLALVGTVWASDSDADDPTGSNNTLHHRTRVLVLQGKSTEVAFNPGSSCHAPLFGVSQCLVTWRKGATVAVNWLGPPPGNVSIELVPVKGGTTYTIVASYPSISQEGYCDGGYGLGVVTHGVECGRVEFKVPSGWSEVGNYSIAVTSLRDDSLVGYTDLIRIAPANSSTADDAPDETSVSLLNIPSPTSTNLAGATVFDGKIPSPTAIVTFSVTTIVASSFTTTSSTKAISLSRASTVSVAPSHPSLASLPASSPRATWVTQPSSSTPTSAVQSSSCSSLSATVPIVLGIYAVFCSIISLFCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N0H1</accession>
    <name>A0A2X0N0H1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C009g05576 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C009g05576</name>
        <name evidence="4" type="ORF">BQ5605_C009G05576</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY82537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N0H1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retroviral polymerase SH3-like" evidence="3">
        <location>
            <begin position="61"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="274"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY82537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="661" mass="73890" checksum="8DC86DCB8264FADF" modified="2018-09-12" version="1">MAIVRAVLAASKLSWKYWSYAMEYATFVANRVLHSKLDGKTAYEVFYGKKPKVSHFHPFGSTVFAQVPKSKRSKLEPTSVRGTFIGYDNEYNYRLLVDSDSEHKVVITRDIAVLNLQPEEVRAPEVTTLFEGPDEDVGPVLEGNDAGDELQDEVAVEQIAPARPNRPRWEYGDPAVRGRNPGRFEEIDAGNEIHQRTRGQRRIAEQQGLFVTDIPELDPEPPIMSGYAMISTDRPAVPSSYEEAMNNVEADKWKEAIQDELNAMDRHQVLADSDLPHGARALGSKWVFARKENAQGEVIRYKARLVAQGFAQRSGIDYNETFAPVARSTTILFLIAIAASQGLCLEQFDYDSAFLNGTMTEMVYMKYPKGWDRPQLGQVLRLVKSMYGTKQAPREWNSAVNKLMVACGYSRSDADSCLYVKRVEEMFIYITLYVDDGLAASNNQTFLDSEIQAFNKVYQLKRLGLVKVFLGLEFLRSSKFIFVHQSKYIRSLVATYGGDHGSKHPAKVPMEPRLNMEHSAELFDDIALYQSAVGALQYAAHRARPDIVTSVRAAASKVSAPTQADWIAVKRIIRYLQGTIDWGLKYNLEGSTVFELYSDASWGDDMLTGKSIGAFVSIMAGAAISWQSKQQSMASLRLGPTMIRSALDGPRQPNAFASAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N267</accession>
    <name>A0A2X0N267_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C007g04831 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C007g04831</name>
        <name evidence="3" type="ORF">BQ5605_C007G04831</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY63784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1252"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="696"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY63784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1491" mass="165446" checksum="72B8B6DA151DD5C4" modified="2018-09-12" version="1">METGDTGPPPGAPPPPSASAATSVPIGTKETQVPIAAATYATAAIQKTKQTPEQQTQQQHRAKALTQMFEVMGAVPGNRTDRWLQATFATDEYPVATATSLKYSALNANRSIRNIFDFALDVTLTVQGASKASPADKADLLGCVTRLLSPQSPLCFDAEVTLPEHLAAFAPQIRGIQHSSFVRAGVVNHRISVGFVSAKARDSALTAPLALTWHSAKAHFAKAHHFYHNMVELRINVGVAAVPSRDAIVDSFKSIVTKITAKGHRCELVQVLRVIHVDNDSAYAHLAGEFSAFIRFDDDALFKAPNNTLKELLPSKVSLATRGNMHTAVRHDYEREAACARCHFVGHVETCALEQERRQKEANKNTGRHNKHHNNPTNTTTNNNDTTNTNNTDNDASEVVAPSRALGTDQLESRNRFAGLEVEGGQEDDIEEEVAGKEGEEKEQVEEGDEDTGAKADDEDSDSDGNAGAGIDKAGGDGKDDDKDDDEDDDKDEQDDSSEGSERRGDDVMKDGAEEEDEGMETEVEEEVEQEQGVQDDSIMIIDDGQTTITTVSRESTPRSPSWPPLSPETLAKSLREGAEWDRANAEAAARVQAENEAIINAQLDAQEPLVRHQFAEWGQEDGQLRFINIRGTGSRSNKKMKRSQTVADLSDPSDDPVDVKRVLNRVKGRAGKEVAGQGKRVTRSMSAAAAMQVEGAKAKAEKGKGVEEEKRWSDHEPEDDILPEFPLFEDNITAKSTWNVRRCMGIPEKRRDIYTYLSTFKASAILLQEHFIKPELWQCIKDEYEGKAFISKHCLTLIPADSPLIDAEILRTHSALDGRILVTSFRLRGDIRILEINNLYAPVDTKQRLTFFDKLHFHRTQSTHLRLLGGDLNDCPLPAIDRRNQGRHGHHWPILIGKLDSPYTDCIRFKHPLTPSFTRPNIVRKRPKSFSRLDYFLLQRTHQKRLVQASTIYDHPKDLSDHRPVSIVLVLSDERGDAAQPNNSLPTTSNQLHRINAATFKTAAFQGMLEGWLEGASGEEPVGELEVVLGNCEKEGRELARREHRERVERMAVLVGRVQDLEALPVMGDEETAEWTRTTEELRRAVNERARQLRIRAHVPEIATEERLSRPVHAKLAARSSDSKITALRLPNGELTHDIDVALDHTQAHFQRLYNLEPRDRDHVERLRDDFLAPIRAARTCDDPSSDPLFLRRLSEAHIELLQQPITEDEVVAAIATTHPGRSPGPSGVPYELYHTAPRAWAKALSRAFNAMTERGSLSPRQGQGLVRLLFKHHKIGADRAELSSYRPITLRECDYKLFTKVYVARLNHVLPDLLPPQQHGFVKGRRSADASFHLRLLIEELGARGTEFPDAALLSLDQSSAYDLVEHEWIFAIFDALGAPATFQRVLRMLYSGDSTTARYIINGFLTPPVRLTCGLGQGDPASSSVWDVVFQPFLDALHRRGIALNLSLPTIHPYPQSRAITSLAFADDVVVAVAGSESLTLLDDLALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N556</accession>
    <name>A0A2X0N556_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C029g10645 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C029g10645</name>
        <name evidence="2" type="ORF">BQ5605_C029G10645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ15128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N556"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ15128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="494" mass="54474" checksum="7ADF50FE04FD0736" modified="2018-09-12" version="1">MSLRTKASEDVLDRGGYCLRRSSSVQIVQRPEFELDRARQARASDHTAKPLTTSTTAASRVVVSPGPADDPHSGPTHLHLPKALHESQVCAATHRCRRDSLTSDERHDHPASTTAALATLDSHSSTTSAKSHQAPTTPRRNDKRPARSESKAEVQDAFFPRKRQRTDMSLAVSDTEGTEDKTFEVMHSKPQYSTPYFDGPSNPPDAQGGPDGLSVLAATISARLDHLEAQLAPLINVLPRLIDVLTAPSLDHIKSDVGSAAKIFVSTPFLCKHHGAAPMFAVESDVKHRAFYKALMCHLPSALMQGRSELEDHIKPAQGDSLVLGTTMKSWYKNLEVTITDEHMCWWRVLWQAVKQPDRKATVEADLTGNESHKTANVPGSRSNTFAEKVNRVSSTLAEMAVDAYLEGEYKHGLEFDHQRFLTDRLAPVMPRHDGIKTSQPGRRQNLMQISCLEVVENPDHEISFASLVEGCLQADKEAAQNPKSKKKKKKTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N6F4</accession>
    <name>A0A2X0N6F4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Iron-sulfur cluster assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C008g05217</name>
        <name evidence="9" type="ORF">BQ5605_C008G05217</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6 7">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; iron-sulfur cluster biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NifU family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N6F4"/>
    <dbReference type="STRING" id="796604.A0A2X0N6F4"/>
    <dbReference type="UniPathway" id="UPA00266"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1010.10:FF:000008">
        <property type="entry name" value="Iron-sulfur cluster assembly enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011339">
        <property type="entry name" value="ISCU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01999">
        <property type="entry name" value="iscU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY ENZYME NIFU HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82649">
        <property type="entry name" value="SufE/NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="NIF system FeS cluster assembly NifU N-terminal" evidence="8">
        <location>
            <begin position="36"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY79763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="185" mass="19680" checksum="0AF359588C8D8EA7" modified="2018-09-12" version="1">MFSTIRSAGRIGATSRSAIVRPSVVASRVPLVASRAYHEKVIDHYERPRNVGSLDKKDNNVGSGLVGAPACGDVMKLQIKVDENGIISDVRFKTFGCGSAIASSSYMTERVKGMTLDQAGAIKNTEIAKELCLPPVKLHCSMLAEDAIKAAIADFRQKKEQAAAKKIDVSSLRAKDAGAQASTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N7Z5</accession>
    <name>A0A2X0N7Z5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C009g05818 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C009g05818</name>
        <name evidence="4" type="ORF">BQ5605_C009G05818</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY86444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N7Z5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032549">
        <property type="entry name" value="DUF4939"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF36">
        <property type="entry name" value="RETROTRANSPOSON GAG-LIKE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16297">
        <property type="entry name" value="DUF4939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4939" evidence="3">
        <location>
            <begin position="244"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="156"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY86444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="467" mass="51858" checksum="C758078B0D505725" modified="2018-09-12" version="1">MRRELRNKKGGPHWDRPSHGQSRASKSSPQGGRLAGSRNDRGAPVELRVDSSCHESAVRGLSAAPPRSLLSAGNFLGASSYLYDLAPRSLPLASTCFHEFLSLSLGFPATINRASYSYKNNYINPASRPVILAIACCLRLSNLNPDSRSRFPIDLVDLTQASLDSLIDQLRTLQARNQALEAECRSHLSDKENYQITVTALANQQQTLSDFAKAVVDQQKESIDVIKSGLANLNVTAPANTTITPVKSQLPKPDKYDGKEKVKFKTFITQIKFYIFGNPSSFPTDKSKIAFIISHLTGDAFQHFEHAINAKDNSKPEWLTNYQKFLDQAELVLGDPDYRNNLTRQLMSLVQSGPASVYASKFTQISSQLDWNQAALIAHFHKGLKLDLQAQLALHDDPQDLQSLIELAIKVDNKLHLARHRTNASTQFRQTNWQYSHSVNSPLRTSPVSQLQVNPSMANTSVVAHTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NA02</accession>
    <name>A0A2X0NA02_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C033g11201 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C033g11201</name>
        <name evidence="5" type="ORF">BQ5605_C033G11201</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000066">
        <property type="protein sequence ID" value="SGZ02313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NA02"/>
    <dbReference type="STRING" id="796604.A0A2X0NA02"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000037">
        <property type="entry name" value="Nonsense-mediated mRNA decay factor (Upf2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039762">
        <property type="entry name" value="Nmd2/UPF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007193">
        <property type="entry name" value="Upf2/Nmd2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 2 UP-FRAMESHIFT SUPPRESSOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839:SF7">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04050">
        <property type="entry name" value="Upf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G" evidence="4">
        <location>
            <begin position="468"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G" evidence="4">
        <location>
            <begin position="675"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="416"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="908"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1050"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="434"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="911"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="935"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="954"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="1022"/>
            <end position="1031"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGZ02313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1152" mass="128683" checksum="ECFEC14B948A8054" modified="2018-09-12" version="1">MSSTAATQAPVDSSATTSNPSATTSARWQRRLQLRELNLAAWAESSHEPHHQARLDTSLKRHTTLLTRLRSSIHTIVTLPAILKEIGSLSLDKYVEEAVGATFEGLAKCKTGPETWAAIEVVSALHQRFPHTFTPPLVNLILTSLAPSTPSAANDREVREKEDTQRITKQRGLLRLMGELEVVGIVGKGSSTASAKTLSVNSGMLTSDKEQLSLVAPLAIAFAKHLGPLYLPPLATTADETAVVNAHEFPALSNSKDDAENSYLVPREMMDKFRKLLVAYLDALGRKEVRNHLELQKQDKRNHEAYIRSGEVFEDREKAYERNVKNWERGWSGVTQLSELLGVAAPVLPSLTSTLAASSIVGTGTSSFQQEEEIGGPGSIWIDEEDKKFYEDLRELKGAVPGKFLGLGDKEVEATVAEEEKENEDLKMDVGNETTDEPESTEADETPSTEQPVSAGTEVDATLATGPAAQLTALFARLVDASSRSSIDDIAIEFVFLNSKAARKRLVKYLASINRNRQDLIPYYARLVGTLNPYMPDVGKELITILEEEFRYLQRKRQVDLAETRSKNLRFFSELTKFKVTPIHSILHVFKVLLDDFTGANIDNFCTVLEGCGRFLLRSEATSERMRLVLETYMRKKAVMHLDQRQITMLENAYYQCDPPGRPAIPPKERTPIQLYIRNLIYHQMTRNNVDKISKLIRKLHWEDPAIVAKLHSAFTKVGKIKFSNIHLFAVLLDELVKFHSEFVVGVIDEVMENFRLGMEVNNFKYNQQRIATIKYLGEMYNYRVIESRVIFDTLWSLITFGHPQGHAHPTTPSPIDMPDDSFRIRLICVLLDTCGECFDRGQLRKKLDTFLIFFQTYVLTKRGIPMDVGFMVDDLFEKLRPKTNRFGSLEEAEKVVSELRNQAGVAANGVNGGADKGGKIGGAIVEEDEDDEEERNRMDVDSDAGKKSGEESSGSDDGSEDGSNDDEGESSDEDDEDDDSDEHSLEEDEDVEGAVRPKDPNAMTEEQEDEFTRDLAKMMAGTGGSAGGGTEVRNKPVLFDVGVPFARKTAPRGGRIEEDEDIDREEATPKGITFTLLTKKGNKQQTRSMEIPLESSIAVHTLEKRAIDKAEQQQLKKLVLDYEQREEVAEKQAFKDDMARRGIALKFKVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NIB2</accession>
    <name>A0A2X0NIB2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C043g12087 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C043g12087</name>
        <name evidence="2" type="ORF">BQ5605_C043G12087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000117">
        <property type="protein sequence ID" value="SGZ32129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NIB2"/>
    <dbReference type="STRING" id="796604.A0A2X0NIB2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ32129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="525" mass="58775" checksum="EA917D9D3DAD543F" modified="2018-09-12" version="1">MAREVDSFRDAMYKIVTPLDAGAFEANIKALAKVAHVAPYLAAIPKQIREGFDFGIKDPPSEPHIAKNAPLTEKQQLDELEAAVGPFRTNPISYVPKSVAPGMPPKWGQIENLSFPTAKPIDRTTDPDEANHPSTGGHGPSQRSGSSSRPKLVSINDDLKSADSPCRWTTLPMLYPKFRELPSTAEVCGWDLADAFYQLPLRWDQRSSMCILWRGLIFVRQVPRFGGSTTPGVFGKVADLTQDLVEWKFPGVSIFKMVDNVCAVPTSDAISQEAVLHFVRSLGWRLAEQKGFTWMRQFFHVGIDWDLDLMTATVTDQKRMRYNDRIDALLKGSHADQKECSEVESVTGSLGYVAYILPALRTHLNCLYRQYIAYGDRKALSRARLDRRTYDQLEYWRRFLSSEGPLSKSFEALPIPSKLALALNACVTNQQSEKSLLSSFCNHDLIVNSPSNLQPPRPLFWSYKNNYINPAPPCMHGLGIVINRYSAYFALPEGWTDLPPPRHSVSITNAEAWAVEALAEAALRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NIW4</accession>
    <name>A0A2X0NIW4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C070g12871 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C070g12871</name>
        <name evidence="2" type="ORF">BQ5605_C070G12871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000125">
        <property type="protein sequence ID" value="SGZ34505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NIW4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ34505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="547" mass="59015" checksum="3CD93BF330066316" modified="2018-09-12" version="1">MVVTAWIGKKARSFYWIVFCRLPTAQQPALETQPRRDIRRCRGDESMQTGDPGSAPGARAPPPPASAPTSLPIAGTKETQATQVAGRTATYAAATNSSVVSNETPAQQQDRLARLQALPGILAAIQAVPGNRADRFVQAIFATPDFPSTVATALKFSALNATRNIINPFANALEVSLSHKSTGRASATDKGELVACVRTLLSPNTPICFDTGVPLSGDLEAFMPRITGLQHSSTFRTGVLHHRITVGFVSAEARDAALASAPMLVWNSANARFAKAHPFHRNMLEMRINVGVVRPPSKEQIVAAFQSIVQQLSTKGHSCQLVQVLRVIHVDTAKAYAHTVGDFSAFIHFDDASLFQHPTTTLKEILPSRMDLPTRGLDVTAVRHDYEKEAPCARCHFAGHVERCPLMQAANRKEAEDLARHAVMRGAGMVGEESRQEWVVAPSRALGTDQLESRNRFAGLEVEGGQEDDIEEEVAGKEGEEKEQVEEGDEDTGAKADDEDSDSDGNAGAGIDKAGGDGKDDDKDDDEDDDKDEQDDSSEGSERRGMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NN06</accession>
    <name>A0A2X0NN06_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C010g06171 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C010g06171</name>
        <name evidence="2" type="ORF">BQ5605_C010G06171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NN06"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY14399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="159" mass="17983" checksum="9FEBA9A543075A9E" modified="2018-09-12" version="1">MSVQTPRPVRGPPRRHPSIEFRAPPLRSASRASPSTTPAPNHSTKPTTVLGHWRPRLTQEDRRNSSELRRKTKVILGEILGEDSTPRPVQIEAIAALFELDQFANRDWYDAVNHQAANLNRKGKKAVVVSEETWRDGKLYMQMDDPNHTISFILIVCVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NQ47</accession>
    <name>A0A2X0NQ47_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mannan endo-1,4-beta-mannosidase</fullName>
            <ecNumber evidence="4">3.2.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C012g06996</name>
        <name evidence="12" type="ORF">BQ5605_C012G06996</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random hydrolysis of (1-&gt;4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.</text>
            <dbReference type="EC" id="3.2.1.78"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.78" evidence="4"/>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NQ47"/>
    <dbReference type="STRING" id="796604.A0A2X0NQ47"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045053">
        <property type="entry name" value="MAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451:SF39">
        <property type="entry name" value="MANNAN ENDO-1,4-BETA-MANNOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26410">
        <property type="entry name" value="GH5_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015997287" description="mannan endo-1,4-beta-mannosidase" evidence="10">
        <location>
            <begin position="23"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="11">
        <location>
            <begin position="364"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="115"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="137"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF26410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY16802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="600" mass="64587" checksum="61C56EA156C71843" modified="2018-09-12" version="1">MLTPRVVVLTLAYSVLRWTALPQDLSSSSSLRSSFFVSAHSGPSSGTAHDAAAAAAAGRPAHENDVYAAADGESLSSVYERAAWVDEGDLPQDEQFMIGGDSVLRNLGHVGSMLDNEGSGGDLDKRWPPNPKWTMRKSPAATTPSRTTTKGNSATPVVPPATTTTTTTETTTTMPKMTTTPTTTPVQNASVTTTATGYTLPKPPLSTCGAPYYSNTAGGVIYGARIGNVAWRAVPTSFVKRNGAYLTLDGKGYRIVGPNAYWLGLDENVNYGISYPDKSRIREVMAVTVALGGNTIRSHSLGVSTGNSLSVWPNAYSTNLNAFDTIDYAIYAARAYGLRLIIPFTDHGGKYDFIRWAGGDTSDGNSFYWNSDIVKIFKDYIKMYLNHVNTYTGVALKDDPTILGWETGNEFGAYMLGAGAPPATWTSNIASYINSIAPNHLIFDGTNGLVDSSGFLRNTGVSVANVDVVTDHFYPALDWLLSKGQTMMGSYSKSFFIGELDWTGMKGGSDMASFYSTIESWGSSGSMAWNLMSHDGQCCNWIYHFTSLQNDGYSIYYPNGHTQAEQASLLALAQHWHRMRGLTPPTVLAAVACPQLPIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NV12</accession>
    <name>A0A2X0NV12_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C005g03725 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">BQ5605_C009g05821 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">BQ5605_C083g12991 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C083g12991</name>
        <name evidence="2" type="synonym">BQ5605_C005g03725</name>
        <name evidence="3" type="synonym">BQ5605_C009g05821</name>
        <name evidence="2" type="ORF">BQ5605_C005G03725</name>
        <name evidence="3" type="ORF">BQ5605_C009G05821</name>
        <name evidence="1" type="ORF">BQ5605_C083G12991</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000034">
        <property type="protein sequence ID" value="SGY28196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY86485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NV12"/>
    <dbReference type="STRING" id="796604.A0A2X0NV12"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY28196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY77784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY86485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="136" mass="15080" checksum="36596F51361C5D98" modified="2018-09-12" version="1">MGYTFVYAGAAVSWSSRLQSRVADSTCDAEYLALSHAGKEAIFLRQLFGELGLSSSKPVLIYGDNQGANALTKNPVFHARTRHIRLREHFVRDMVSMGDIVVQYINTGEMTADIFTKALSRDLFARHRGRLGICAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NV17</accession>
    <name>A0A2X0NV17_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C012g06790 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C012g06790</name>
        <name evidence="3" type="ORF">BQ5605_C012G06790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0NV17"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1289"/>
            <end position="1574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="677"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="585"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY16172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2107" mass="235506" checksum="1E68D103243F8FB8" modified="2018-09-12" version="1">MVVTAWIGKKARSFYWIVFCRLPTAQQPALETQPRRDIRRCRGDDVQPPRDQIPISSKKTQATGPATAAPNYAAAASQMATQSPEQQQQQQQRAKALGSLLQAMGAVPGNRMDRWVQAIYFAELYPVATATSLKFSALNANRSVENIFDYALEVTLSHQSASRASHADKTDLVACVTRLLSPISPICFEPGVPLPDHLAAYRPQILGVQHSSILRNGAAHHRVTVGFVTGEARDAALTTPPALTWRSAKARFAKSHRLHHNMVELRINVGVQGVPSMDAIIKSFQLLVQDLSGKGHSCQPVQVLRIISVDNASAFAHVAGDYSAFLHFDDDSLFKRPNTTLKEILPSRIGLPTRGIPVTALRHDYEKEAACGRCHFVGHVGTCGLDQESKRKEAHNGNGNANTNANKNTITNDTNIVEAEAPIPVPVVNRIASQNRFAGLEVEEGQEEAVTGQSGQGPEESGEEDAGDKADDEDSEDSEMESEATAKTEVIKLKSEDESVLEDCGGSDGEVIDEDEVMADGRGETEGKVATEMEEREVATEMEEEEVATEVDDVDEAGGATKAENAEATDLGETNRLDNDDDSDATATAATASRESTPHEPTPPLSPETLAKSLREGEEWDRIRANWVEQARLERDQSIERRLDAETPLVRHNFATWDEDGEIRSINIRGTASKFKKPVMKRSQTAADLSDPSDEPTDAKRVIIKGKSRVVVKDGTEGRRVTRSMSAAAAMPVGVTKVDRGKAKGVAEEKRWSDHEPEDDRFDLNYPLMIKHTIITWNVRRGMGVPEKRRDIYNYLSLFKASAILIQEHFIRPHLWQLIKDEYEGKLFINQHCLTLIPADSSLIDAELLRTHSALDGRLLVTSFRLRGDIKILEINNVYAPVDPKQRAKFFDKLLFHKTQKSHLRLLGGDLNDCPRPEVDRRNQSRRGHHWPILIGKLDSAYTDCIRYKHPITPSFTRPNPNRKRPNSFSRLDYFLLQRTHQKRLDQASTIYDYPKELSDHRPVLIVLALSDDPDATLPQLSLPTTSNQLHRINTTTFKTVEFQRMMEGWLEGASGEEPVGELEVILKACRDRGGEMARRLHRERTERMEYLVGRVQDMEAIPEWGEAETAEWTRTSEELKRAVEERARLLRIRAHVPEIASEERLSRPVYAKLAARNSDSKITALRLSNGELTHDIDVALDHTQAHFQRLYHIEPRDPDRVDRLRDEFLAPIRAARTCDDPRSDLLFLRRLSESQIDLLQRPITEDEVVAAIGTTHPGRSPGPSGVPYELYQTAPKAWAKVLTKVYNAMIERGSLSPKQGQGLVRLIFKRHKKNADRAELSSYRPITLRECDYKIFTKVYVARLNQILPDLLPPQQHGFVKDRRSADAALHLRLLIEELGARRTEFPAAALLSLDQSSAYDLVEHDWIFAIFDALGAPATFLRVLRMLYSGDSTSARYIINGFLTAPVRLTCGLGQGDPASSSVWDIVFQPFLDALHRRNIALNLSIPALHPYPQSRAITSLAFADDVVVAVAGLGSVNLLDDLALDWRHATNGRLNTDKTVVLPIGRRWDPGQRPLVVKAAGESLEWIGLPFDPSGDTELAYANLIERLEATLEGVQHRWLTHHTRAFYVNRYAIPKILHFLAADIPPPEVVKKLDDMLVDFVRGGNGRTSYGRDIVFTAKLKGGLGVIRMQDVVDAVAARIWDVLLGGSGAIWQGLARAALQRAQSDLDLATDLWPHPSTPIPSDLHPRWRAALGVPKQQDAQVNPRTLTTANLLALPTLLGSLHTPIRGRQTIDAVHIPDYLRLQGYPKVADLYRRELYAGGGFHLWTPPADVLGDNSEYDRRGLPQRLAIAAWYRFTVDRHKNTPLAVAVAAGRLNVPPRIGTSAPLEAILPKPVARFAMEQRLPDPVLPQQASQYKLLNMARPYTIRRIRRVLNAKAFTNTLGLKGPPQPDDLRSFWKAVNSKALTAREREVWFKLILRFTPTRKLQHQQQHDTSPACLVCEAPVDDTDHYFFGCVDSRNVWIAARGVLCDALGCDTIEDAQYTTLQRLFGLPKLKASLRDQEGAGRTIEIFTGLVLEMISSGRWGMQKWGTRMEGVVRRRIILEERLKLRAGGAWGRRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NWA9</accession>
    <name>A0A2X0NWA9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C015g07875 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C015g07875</name>
        <name evidence="25" type="ORF">BQ5605_C015G07875</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="510"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="257"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="785"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="267"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGY17745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1378" mass="153531" checksum="DDA4740E08A5FDAC" modified="2018-09-12" version="1">MSPSETIAQESGEIKIAKLGKDNYELWSIRVEAYLESKGYASVLEHGHVRPSDVSLAEWRTMHGLDASVTDTQVVVNLQKKDRSARALIIQCIDDANLKMVKSKTLSAKDIWDKLRQHHEGNAKPFKIRTLLMELSNAKYDEDENMGEFLKSMIDKADQLDDLGQKFGDEAMIAYILQALPPSYEMLKQAIRLGENRSVDHVINRLTDEYTERKLSGKFDKLLKNAGALAVQSTQASRDPNCVCRGCKGKGHFAMDPECPKYDAKKNHGRARNRNKKKKQDSKESADSNELAEFVLMVKSLDESHSLQDNVANRVSQVNQGEIWILDTGASQHYVGDASLLSNRQSGNLKVQTASGQVVHCDTYGMVRFKLKSGASLSLANVYHLPGAPVNLISTRALFKSGAKCGWEDGKDVMTITYQGVILAKTLSGTGYALDFTRIVEDQAHVATRATVGAPLMEWHRRYGHVPVSSIMELVKSGAVEGLVLTDEKVHDCEPCISSKSRASKFSELATQVTDVLQRVFMDIGFVAEDQVDFQGRKAYLAIVDQYSTAKWMFPLKTKSAEEVTRVWIAFRQGVEKMTGRKIKRVRTDNGTEFTNKLIGADFQSQGILHETSAPYTPQQNGTVERFNGSLMAIVRAVLAASKLSWKYWSYALAYATFVANRILHAKLEGKTAYEVFYGKKPKVSHFRPFGSTVYAQVPKSKRSKLESTSVKGIFIGYDSEYNYRVLVDPDSDHKVIVTRDISVLEHKSEQVGVPEVTTLPVGPDEEKGPVDNDEIVVDELQDQVDGEQMPPARQNRPRWEYGDPAVKGRNPGRYEEIDANNEIPHRTRSQRRDAEQQVMYGSAMSVSLPPVPSNYEEAMASPEADKWIAAIKAELDAMARHQVLIDSDLPSGARALGSKWVFTRKENAQGEVTRYKARLVAQGFSQRPGIDYNETFAPVARPSTILSLVGTAAAQGLFLEQFDFDSAFLNGTMTEMVYMKYPKGWDRPQTGQALRLVKSMYGTKQAPREWNAAVNSLMVERGYKRSDADSCLYVKRVDEKFIYITLYVDDGMVASNDQEFLDSEIEAFNKVYKLKRLGPVKLFLGLEFERKSDYIFHPVKVPMEPRSDVEHSTDPFNDVALYQSAVGALQYAAHRARPDIVTSVRAAASKVSAPTQADWIAVKRIIRYLQGTVDWGLKFNHGGSTVFELYSDASWGDDMSTGKSIGAFVSILAGAAISWQSKQQSMVATSTTEAEILAASAAAKEAMWLRRLAADLELEQPKATLIWEDNQAVIAIALNPAHHGRTKHYNVHHFYIRERVTAGDIRIKYCKTGAMTADILTKPLARNLFELHREGMGMVSLGALTSGKAAGCLHEIASFWPSCFSLFSTTHSISHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NWY6</accession>
    <name>A0A2X0NWY6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01704 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01704</name>
        <name evidence="2" type="ORF">BQ5605_C002G01704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY34938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NWY6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY34938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="417" mass="43610" checksum="BCDAD8DFA059FBC7" modified="2018-09-12" version="1">MSALAPVARAASIPIPRVAGGVVLKPIFVHPSHFEGSAPTSPYLDPSASSPFNSSYSMATSSSSETPDAETLARVENISLDFSPPSPSLSLTSLDSLDSCNPSTDFFAAAFGRSTSNSDAESYFTLDTSPSSSNSSTPTCESPTASFKPASEASEVSSSLPIVFPASFPFATFAAPVSRPASPPVSAVLRRASTAGGSMMARSVSSPVETQRELDQRRRRQADASELMHESATKMARTRSMAAFGSSSMMSRAPSGFGLMPARPVTPVTQPSCPSPLVTPFEEGWGAALPPREKAEPAALPPFPFNHVGVNYSPGRLNRSHSATYVPQYRAPRSPEISSHLSDAAIASLSASSFSSQLPDAPLMVTIPNSPSMTRPRRSTLGLAALTPIIPTQGFEVPIDALPPMAPGRLTRGASFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NZ03</accession>
    <name>A0A2X0NZ03_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C017g08463 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C017g08463</name>
        <name evidence="2" type="ORF">BQ5605_C017G08463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY20094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NZ03"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY20094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="80" mass="8872" checksum="BFE4376AAF5B352D" modified="2018-09-12" version="1">MRPNPVVGAGSSSKKRGLSKVITLEDDEDEDEVVEEEDEDFNIPVRRGWLIHVGAKNRPSGSVREPAPSRKYRLITAVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P221</accession>
    <name>A0A2X0P221_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g04187 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g04187</name>
        <name evidence="2" type="ORF">BQ5605_C006G04187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY56877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P221"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13975">
        <property type="entry name" value="gag-asp_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY56877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="619" mass="69608" checksum="9E72D06A773A78F7" modified="2018-09-12" version="1">MKQLGTSIELFVIDVIDKIDIIGQLLLDPELEVWYSSDAASHVNKKYGVFQRDLTLRALPSDYMWQHYRRLDNLRQTGDYREFSTAARDLQLELGVSLVSDTQLVRMLLLHMDEELSQRLRLSEVIKGTGLSPDKLDASIVKADSTTSSAVFDYQTFDAEARRLWQVISATRASVKATAQASAKPSNQGCFKCRKINAGHFKDTCTTWATSACKVPAGWRQGPVSPEQVASLSDAVDEIDDKGEELHCLCDDEYDNGTDDERCEPISLSVKLTTEDGPALRALVDTGASASFIADREVEKLRLTRRKLQVPTSVSVAIQSHRVSHAVTEFVRVPLRTLNGRWSTQHVVLKIAPLTSLKVVLGRPFLKRHDILVDCKRRRVLAPDPTLPRKRIDLMHRGEKGEWSESAVQASIRACLAHLEEQQAEESQLRALEYESKVRHRIALKPGMKTPRQPTYGTPMRWRAAWRRLLDEHLAAGRLRPSLSEYSLPAFIIPKKGMDTDPSIMPRWVNDYRILNAATVPDRTPLPLPDEILAVAARARFWSKINMTNSYFQTKMAEEDIPKTAVATPWGLFEIATKRAKRGNKATTTSSWVKIKPLRAKSAAQIKARRAPNADSNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P2Q7</accession>
    <name>A0A2X0P2Q7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peptide hydrolase</fullName>
            <ecNumber evidence="14">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">BQ5605_C002g01809</name>
        <name evidence="18" type="synonym">BQ5605_C049g12459</name>
        <name evidence="17" type="ORF">BQ5605_C002G01809</name>
        <name evidence="18" type="ORF">BQ5605_C049G12459</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase M28 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="14"/>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY35849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000111">
        <property type="protein sequence ID" value="SGZ30770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P2Q7"/>
    <dbReference type="STRING" id="796604.A0A2X0P2Q7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03875">
        <property type="entry name" value="M28_Fxna_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000008">
        <property type="entry name" value="Endoplasmic reticulum metallopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048024">
        <property type="entry name" value="Fxna-like_M28_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF22">
        <property type="entry name" value="ENDOPLASMIC RETICULUM METALLOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 14" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="480"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="588"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="646"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="683"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="712"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="16">
        <location>
            <begin position="189"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="SGY35849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="SGZ30770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="998" mass="108817" checksum="BA8A7C4E6782250F" modified="2018-09-12" version="1">MSNNRHPSIKGILKHRPQLATDFEVDDNPSSKPVAAVAGAPGARASASRVPSQHRRWGFLPAAAVLLPFLVSLAYLSLRVHYTLPTPNPSLFAADGKTPLFSETRGMDIIRALATHPDGEPRYRIIGTEELVETEQWVLDEVHRIRDDVITRMQGHPVQIETWHQIGSGEHLFDFLDKKVWKKYFDVGNVIVRLSDGTAASKKNAVLVNAHTDSTLPSPGAADDLIGVAAMLEALRVMALTPRRLSNSVIFLFNGGEESFQDASHLFITQHPLKDSVRAVINLEACGVGGPEIVFQATSEEMIKALSKTPRPYGTTLASEIFQTGLILSDTDFRQFVEYGNLTGLDMALVQNSYLYHTRLDVPELIEPGALQHMGENTLALLEYLTSNETALGNSPTAKKLPKMKSAADTIFFSSMGGKFFIMYSRAQGALFERQSILCSNITDSCTLCPSSATAIYAVLATLAFIVVSDRLVRQRKRLYVLTTAGVGLSLLAAILGSNLAAAATSIVMGKTMIWLVKASGNLRSRSHCIDGAPSIRRFSNESFAVCLFGPPAAFAVCLLQRSIAKRVRTHGASPALEAHESSLLEHATLMGQLIYSTVILCLGHALGVGSSYLYAVALVSNLTALVVNDYVLTSGPEREVHLATYFFQQVLGLILGVETLVGFLDIFVPLTGRLGADAPVDFIIASLTAAVGFLALPMLPPILHRFGPRSASRAAVSLTFVTAASLGWFTRPTSSPYDRLHPKRLLVLHMENTTTTPPQFDLHVASVDGAPFQDLLVEATKGLTASNKVPQALRAHDHSTDWDIIFPVSQFLTTYKVPLPPTEASYVSHFAETFTVKAIRSSLNSISRTRSLEIEMLHPGLIWPVIAFDADVVSWDLPESPARGVIRHHVKSVAGYGVTRFVLSLVVYLDEETFGAVMREQQRAKGQRGDASRSDAIKAKLRIDYSALDSKGMYPSSIRHAGLKQKPGMRFFETFEQQLPEYVDAMLLSAVAGVAYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P2U5</accession>
    <name>A0A2X0P2U5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein YTM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C003g01851</name>
        <name evidence="6" type="synonym">YTM1</name>
        <name evidence="10" type="ORF">BQ5605_C003G01851</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR12/YTM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY37649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P2U5"/>
    <dbReference type="STRING" id="796604.A0A2X0P2U5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03029">
        <property type="entry name" value="WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028599">
        <property type="entry name" value="WDR12/Ytm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF11">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="9">
        <location>
            <begin position="35"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="336"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="395"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="428"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY37649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="519" mass="55803" checksum="7015EEA483BFD6FB" modified="2018-09-12" version="1">MSLTETTYPSVLESLVNGDAPTTASTTATGEERQIAIRLTTQDAPYEIPATKFLVPASWRRFHLSQLINKVLNKDESTPFDFLINQTLLRSSLGAYCAQSGVSEEVTLEIEYLPSTLPPQLESTIPSQDWVSDISLGVNGSVVIWTLLRNLSDQKAILTSSYAGTLSYISTLNPSNPLTFHGHDLSVLSCCYVHNPAGQLSSRAESGWIASGGMDRVARVWSYSVIAANIFKAPSTSLTNPTPSSEVTAPSTLYTLSLHTGPVSSIRARPFPSSSSEIMTTPHLLTGGWDGVVGVWDLTKGVNEGDAIEDDGQERKKKRRRAAPGTVVNKTPVSALLGHTGKISRAIFSSSFLTSSQAYSASYDRTLRTWDLSTAQLLTTRTAPSSSVLLDLAQLSQSTNLLITGSTDRSIGVWDTREDASSHISISLTGHTGPVSSVVGHPKESLLIASGSYDSTVKIWDVRSPKQALFSLDMSREEGQETKDRVLALDWDGEQLVAAGEGAKVAVWRVSGSKGVEAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P2U6</accession>
    <name>A0A2X0P2U6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exocyst complex component SEC15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C003g01920</name>
        <name evidence="9" type="ORF">BQ5605_C003G01920</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the SEC15 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY37928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P2U6"/>
    <dbReference type="STRING" id="796604.A0A2X0P2U6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.30:FF:000004">
        <property type="entry name" value="Exocyst complex component SEC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.670">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.30">
        <property type="entry name" value="Exocyst complex subunit Sec15 C-terminal domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007225">
        <property type="entry name" value="EXOC6/Sec15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046361">
        <property type="entry name" value="EXOC6/Sec15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042045">
        <property type="entry name" value="EXOC6/Sec15_C_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048359">
        <property type="entry name" value="EXOC6_Sec15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042044">
        <property type="entry name" value="EXOC6PINT-1/Sec15/Tip20_C_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702">
        <property type="entry name" value="SEC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20651">
        <property type="entry name" value="EXOC6_Sec15_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04091">
        <property type="entry name" value="Sec15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025007">
        <property type="entry name" value="Sec15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC6/Sec15 N-terminal" evidence="8">
        <location>
            <begin position="121"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component EXOC6/Sec15 N-terminal" evidence="8">
        <location>
            <begin position="202"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex subunit EXOC6/Sec15 C-terminal" evidence="7">
        <location>
            <begin position="497"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR025007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY37928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="879" mass="99100" checksum="B6B20A1049A9502E" modified="2018-09-12" version="1">MASSSHHPSNKTSHHPRRPKFSQAEIQTQLSQLHLVRSPSWAVDASCHHSLIGESMFVESNRLNALTAASTHLLPPSVNLRAIVSMRRPTCCRLHLPISLPPLPPLQIHRSRQQDAYLKALKVFVAEKESEIEAVCAKNYQNFVGSVSALLRVRQGTISLKHRVVELNEEVQKSGGGLAVKVCRCILKSRNGGLVAHSSLTTTPTTAQKKALLEARRVGQNIDEAIDTLQACLRVLDVANKVQSLIENEKFFSALRQIEDLQSTQLKPVLQYPFASQMLAGIPTSRNVIRESVTRSLKAWMYEAREASRAVGKGALNAMEARGRKWTARKRKEPSLGLAKINGPIELSVSERHEYNVLDNDNVKIDFRPLYQCIHIYDSLDAREELQLSYQADRRAQAELLLSQTSSLSPFSLLALSLLLEEIVGFFLIESHVLHTTNSFRSEQDVEDLWDGMCERVVKIVDEGLANCEDPEVFLGTKLKVLTFVQTLEGYGYSVNQLNNLLLTLFERYSQLLQRKFSGDFEQIVLDDDHQSMVVNDAEEFDKVVSVSWLPASGEWSADELKTPGFPLALPFSQTYPLCCIDIRSFTEQYYQFSDGFAEQHRDIDDVLRKALDNLLIKQVSENIQRRLRMISNLSQLSQIVVNVLFFQTACQDLETLLVTLRATQRGGTIHLDSLASFDATLKMTQDRIVTNIAQKMDSFFEEANYDWLTTTTPANGAHASGYLQDLIDFVTTVMMSVLIQLPEFSKDYVYRGALSYCASVLMSWLIDREPTQISDQALMYIAKDVQWLVHHVATLGNDRLADVFQELSQTLTLVTATPIMTDYLSVDERQIKYSRINATRLRTLLGKQLAFYNSHSGAASARRKGQVEELHRALYARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P3P8</accession>
    <name>A0A2X0P3P8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
            <ecNumber evidence="3 14">2.4.1.258</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dol-P-Man-dependent alpha(1-3)-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">BQ5605_C003g02230</name>
        <name evidence="15" type="ORF">BQ5605_C003G02230</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11 14">Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the first dolichyl beta-D-mannosyl phosphate derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-dolichol to produce Man(6)GlcNAc(2)-PP-dolichol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29527"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19516"/>
            <dbReference type="Rhea" id="RHEA-COMP:19517"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132515"/>
            <dbReference type="ChEBI" id="CHEBI:132516"/>
            <dbReference type="EC" id="2.4.1.258"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12 14">
            <dbReference type="Rhea" id="RHEA:29528"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the glycosyltransferase ALG3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.258" evidence="3 14"/>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P3P8"/>
    <dbReference type="STRING" id="796604.A0A2X0P3P8"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052925">
        <property type="term" value="F:dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007873">
        <property type="entry name" value="Glycosyltransferase_ALG3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646:SF0">
        <property type="entry name" value="DOL-P-MAN:MAN(5)GLCNAC(2)-PP-DOL ALPHA-1,3-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646">
        <property type="entry name" value="NOT56 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05208">
        <property type="entry name" value="ALG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="223"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU364047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SGY39510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="475" mass="53193" checksum="E2645FB052ED1862" modified="2018-09-12" version="1">MGGRSDINHPRHPRLRTVPARSSAPMFVSGAQALADKLSDGAAVIAHRSALRRLQQVLTTQRYFGFVAGLLFVFDVALLTLIIRFIPYTEIDFSTYMQQSSLFIGGERQYSLIKGDTGPLVYPAGFLYVYSGIHYITRGGLDIRTAQCLFAQLYLVTLGFVFEIIRRCGSVPPYALVLMCLSKRLHSIYALRLFNEAPAMLPFYAAVLAWTRPNGGPKIWTTGTLLFSLALSIKMNFLLYLPGLLYLFYTSLGVYKTLLQLLAIGSTQMLLAVPFLGTRAKAIDYFTTSFNFGREFLWEWTVNWRWVGQPLFEGRGFSKLLLISHAAILIVLLRQGLKRPNEAPLSFAPTPERVCKILFLSNLVGIVFARSLHYQFYAWYAHQIVFLLWQTEFNLVQRVCLWLAIEVGWETFPSTTNSSLALTIANLVIVAGVLYKTMVAASHSVLAQEKSGWPAASVDFVTDDKEASSATVIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P518</accession>
    <name>A0A2X0P518_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BQ5605_C001g00006 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C001g00006</name>
        <name evidence="11" type="ORF">BQ5605_C001G00006</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[ribosomal protein uS12]-L-proline + 2-oxoglutarate + O2 = [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54156"/>
            <dbReference type="Rhea" id="RHEA-COMP:13816"/>
            <dbReference type="Rhea" id="RHEA-COMP:13818"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:50342"/>
            <dbReference type="ChEBI" id="CHEBI:85428"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TPA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY43256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P518"/>
    <dbReference type="STRING" id="796604.A0A2X0P518"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031543">
        <property type="term" value="F:peptidyl-proline dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006449">
        <property type="term" value="P:regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.20">
        <property type="entry name" value="Oxoglutarate/iron-dependent oxygenase, C-terminal degradation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019601">
        <property type="entry name" value="Oxoglutarate/Fe-dep_Oase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043044">
        <property type="entry name" value="TPA1/Ofd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039558">
        <property type="entry name" value="TPA1/OFD1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051842">
        <property type="entry name" value="uS12_prolyl_hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117:SF0">
        <property type="entry name" value="PROLYL 3-HYDROXYLASE OGFOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13661">
        <property type="entry name" value="2OG-FeII_Oxy_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10637">
        <property type="entry name" value="Ofd1_CTDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="10">
        <location>
            <begin position="129"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="507"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="539"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY43256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="605" mass="66574" checksum="29BBDD53861B93ED" modified="2018-09-12" version="1">MSSSPSCKRSKLSPTLPFTPKLLSPSSIASLRSQVEASQPYKHAVIPQLFEHDFLEKARKELCESVSFTEKETDIYRISQTGDLTNLSGLPAAEQAQLGTLTQLRDALYSSEFRSFLQKVTGCGPLSGIKTDMSCAEYGEGSYLLNHDDVIGTRRISFILYLVKREPEWRAEWGGALELYPVVPSEGDRPNIPEPKPSVSIPPAFNQFTFFKVQPGHSFHSVEEVVIEGQHGPSSRGGIGSRLSLSGWFHKPIEGEEGYEQELKEEQVEGAKGKSSLQQLYKTTLKEATAYEGHVEGGLLEGEGKVFPSDEDRKVLGEVLNPSYLVPKTIAFLQSSFAEQGHLALSSFLSKELSAQIETLLRQLDAGMNKGRKGAIVGGQVVNLTPRHEEGVGKGWALVGPPHLQRFLAWGAELDDDDEDELAVLLKKVKSTFESTSFARLLATLTGVTLKAYTLDLRRFRPGLDYTLARGVEEGHILDVGLGLTPEPEVGRERELWEEGDVGGWEVWLDGGEGEEGDEATYGGGRKKKSTEKQGETGADSEEEEDEEEDGPLLSLEPSWNRLSIVLRDPGVLKFVKYVSAKAPGSRFDLSGEWDVEVAQDKDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P655</accession>
    <name>A0A2X0P655_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00456 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00456</name>
        <name evidence="2" type="ORF">BQ5605_C001G00456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY46652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P655"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="496"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY46652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="579" mass="62170" checksum="638B127C2FA7B74A" modified="2018-09-12" version="1">MPSPSSSDGRNRSHLSKTLPRCISRTRNHSNSFDELYAVGLALNDDEDGIAYVPDGPRSSTNLATFCSSSEGKTASVNIHGRAFGPLSQLEVSIPSRHQSMYHAQHLTYEGDHVTRISTTANACVEDFAPTIDSPISPRTLLPPLFDDKEETTVSSGSGGTLFGSWNGFDADVLAPTGVAPRVTLPVSAAPPIFDYDDDRHRNETGRAGARLPSCEVNGLITVERPSLPPISMATDLAPGAPLLLSSSPRHTPSPTEVFTSPSCSHITRLSRDRANSTISAITSLESALPSGARSKASVAMRRCSTTPLTSKQSDSDELKKTPRGAFSNALLDSFHHLDRRGSLPRVSASTPPEASTLGSSLEADTSLDPTQRGRSNSVISLANLSTVFDYVGRSLTRSLSPKAHHPSTTRERHRPSTRQRTWSFSGAASSILGGSSSTMAPTHYRWEDVVSLRARFCTSSDSTSGLNSFMLGLHDMEHGGKARSWDPRGACPAESVRTSPSSSSFSNIEQNGNPDLTFTDRWPRAETTWGEPARVVVGYVGGSQSVFSPRELTPPQIVDKILNPPSVTFPMSTPRSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P9W6</accession>
    <name>A0A2X0P9W6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C007g04622 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C007g04622</name>
        <name evidence="3" type="ORF">BQ5605_C007G04622</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY61915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P9W6"/>
    <dbReference type="STRING" id="796604.A0A2X0P9W6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000009">
        <property type="entry name" value="Class II aldolase/adducin N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004855">
        <property type="entry name" value="PRK06208.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF39">
        <property type="entry name" value="CLASS II ALDOLASE_ADDUCIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="2">
        <location>
            <begin position="46"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY61915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="273" mass="29376" checksum="25C1A3F465B4A227" modified="2018-09-12" version="1">MSKVGNGPSDHVQENAKGFDYGGSLKELTEPPKFDNVEDERKYLKERLAAALRIIGRLGFDHHVAGHLTVRNPENPHNFWVNPFGLAMSVMTVSDLILVSDEGKVIGGGKPGRRVVNLAGFLIHSAIHRARPDVVAIVHSHSMYGKAFSTLGEELPITTQDACSFYGHISLLTQFGGVVVSGGEGDLIAKTLGQNKAIILQNHGILTAGQSIDSALNWFVMLEAQCQVALLAKAAGTPVLIDEAQTGSERSGYFMASPLFQQLDAEVGDAYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P9X6</accession>
    <name>A0A2X0P9X6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C007g04632 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C007g04632</name>
        <name evidence="2" type="ORF">BQ5605_C007G04632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asteroid family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY61970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P9X6"/>
    <dbReference type="STRING" id="796604.A0A2X0P9X6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026832">
        <property type="entry name" value="Asteroid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665">
        <property type="entry name" value="ASTEROID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665:SF1">
        <property type="entry name" value="PROTEIN ASTEROID HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY61970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="619" mass="68742" checksum="5BE542DC4A801047" modified="2018-09-12" version="1">MGVQGLTTWVDQHTTLCEYHELSSDDAASARSGSAAIPFIIDGLAFLSYLFRLNNLAIVDPIRGGNYLELRRLLRECIDYYRAVGLEPEIVWDGPYGTSKTETILRRGRQAIRTSHDFMRSSDDQRAHLHVISRAARLPLLARSACTYELHQLHVKMHSAQAEADSPTAELAQRSNGYAVSQDSDYFILPAISRGYVPLDRIVYGPGRMARPGMLRPGSRTVLRIGVYQPARIAHMLGIHLERLPVFAALAGNDLANLTKTFHSTSSQGKHSRSRPSRKMDIDKVASIIASIESTCTLEETLRIALAKLLGNVQPSTTMLAELAASARSYELVSIETIIPGFPLQPHISDSPEQAQCRRLYFDEIFARGDSANFIYQATQAQLVVSKITVERPEFRSPCLTLGRPLRILIYAVLDDAIGIGAPDVTEYCRREDDLHATLIPIRTVAECSKSPIRTPLLLAPTGERLRFLAGAFEFTIPSSTTRDKTFRYLPLLLALRHIQSYARVPWSRSMLISALATAVTLSSPGRYHQLRVGTQLPRAANIEHIQTSVELVQTLHYLQILLEALLLAQQLTPCHLLFDGDVLHAFLAEGDEVEKLLGQLSGEQVVNEVLGLLELVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PA72</accession>
    <name>A0A2X0PA72_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C007g04843 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C007g04843</name>
        <name evidence="2" type="ORF">BQ5605_C007G04843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY63887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PA72"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016160165" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY63887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="43" mass="4709" checksum="80CA760FA4904620" modified="2018-09-12" version="1">MKIHIISLLAVLISSKVNAQGLDENLTNLPDCWTTGTHGELDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PAD1</accession>
    <name>A0A2X0PAD1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C036g11466 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C036g11466</name>
        <name evidence="3" type="ORF">BQ5605_C036G11466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000063">
        <property type="protein sequence ID" value="SGY95015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PAD1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="555"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="455"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY95015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1183" mass="127684" checksum="D556EBFD6914D6F7" modified="2018-09-12" version="1">MPDPPGPPPHPPNAPWAGDVLRDESLNTETRETVTGGTVNPPAWSAQASQARLDHEKSMQKAFKALGIVPSSKSTRRLMVLLYDPSSPPSQAPALARAAQRAVRNDAMPASNVIRVIMDGTGSPRGPVQIALRKHFGLAETPFMFARPEGAELDPEVEKLFSKCVKLNPIVTKATKRFPIARHMYELVFESDQACLEAAAAGPFPYHGKEMVTELPSVSPLNHIVQVRFTLPSSSSAIPASVLRKSLDAALTSSFGHAGCTQGYTLMQLQRGLAVDPNGDPMAMTEDGFHCAYLRLHADLFQGSTETQKAALNAALPQEIEILGAKYGLRHEFETHYCAVCDRAGHQWGACRKPVSTPATAAPVPGASTSTSTSTTGFRVAGKNGKHGGPAALNSRASGTNMIQLGPRANPASAATGNKDDANDGDGDDDDDDGESVASTEPEGGDTGKETLTRATTGPTKETQTTTAAPVSTPTSPSPSTSAPASPLSGGTSESSATSTTSIASTSPRHLRSSSAPGNRRVTRAGSAMIHGASGGDDSGGNSSGGYRSESLTVLTFNVRSIKNAVNQVKIIRYLKTLRPAPAAILLQEHHLSYNALREGFESAWPGACIRFAPHVLTLIPDGSPLAGRLLSSTPVVFAEAPQFDGRILRSVFRLEELDIEIINMYAPVKGEERRDFYGLLHFTAPGPKTLRILAGDLNDCPDVSVDRVAITDRAWTPVSHWQTLLSKIAFNPLDTIRQLHPITPAFTRPHYLGRGDKREICSWSRIDYILVQRSWANRLLSASTLFDAPCSDHRPVVATFALPTSNAADAEPPPALPTTSEFISRLNPTVFNDQDFVDSIPGVVDEVYRRLEGTAPLGDVYDAALRAVAAAGHARYRSTRADMRRLRAENQSVMEALEARGEHMNEAERDAYALAKSQLDQLVVKEAQWLRIRAHVPSVDSREGQSASIRTRLNRRSRQTSIVSLEDVDGTETVDMQEALGIASRHAQSLFMPDPARGDPTNARRSLLDPIRAAKCYDDDRSDPTFGRRLPLQARVALDEPFNLSEVEVALKKTDSGRSPGPSGIPYELFKALPTYLRPLSWSLGCAPPPSSPSFPLVLLNKKKTCLVCGAPKDDREHYFFDCVDSGNVWIAARSVLCDALGLDTIDNTHYTAVQRMFGLPKLKASLRDRKERGGQSKYSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PBD6</accession>
    <name>A0A2X0PBD6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C004g02875 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C004g02875</name>
        <name evidence="2" type="ORF">BQ5605_C004G02875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY68291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PBD6"/>
    <dbReference type="STRING" id="796604.A0A2X0PBD6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY68291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="527" mass="58817" checksum="0A51A038F934F0B8" modified="2018-09-12" version="1">MFKLLPFVSNEPSSLDSYESERRNSSVPLSNFHRRTSTTAARSTESPYSKEHDSRPSSNQGLQLRDPKTESTSHYHRIDRRDSYSRLTAPSTPSARHSVRAVAVLGWLVAFVLFLAMAMTNSDAESRKSSVMSLRNVTQPYLETVGKLGSKAGFDVSAFVRFPAPSQSFAGAASKAHSHSGTAEVVEDEAPESRVTLISAFYRIDSGKKHRVSEYHAWLSNFLGHVELPIVFYCAPEMRPLITGLRGSKPITIIDSYDNPFDMPPLETLGGRQWAELQNSIDPEKNWHVPDVYGVWTAKPWMVQQVKNADYYNSEYFVWASLFPGVAADVITCAHQLNLCHHSCCAQVDAGAFRDSSVKHNFLQLEKKLDHIYSSVPDDTLVLSAAQEPFAPGLDYVNGATAGGELDRSDRLQGGYYGGKAAGIDWWAEETMKVTIRQSSLQKFTAKEQPVWNQAARLNWPRIYVQNMALRQGTDCGSDVWFAFEYFADGRDCAIPVWSGPEHKAKFGAPVSKVRANRRAPPPPRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PDN0</accession>
    <name>A0A2X0PDN0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BQ5605_C005g03687 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C005g03687</name>
        <name evidence="11" type="ORF">BQ5605_C005G03687</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PDN0"/>
    <dbReference type="STRING" id="796604.A0A2X0PDN0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09251">
        <property type="entry name" value="AP-2_Mu2_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14836">
        <property type="entry name" value="AP2_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000002">
        <property type="entry name" value="AP-2 complex subunit mu, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043532">
        <property type="entry name" value="AP2_Mu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043512">
        <property type="entry name" value="Mu2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="10">
        <location>
            <begin position="199"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY77651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="460" mass="51439" checksum="644C422691840294" modified="2018-09-12" version="1">MLSAFFILNLKGEVLISRLFRPDLKRSISDIFRIHVIASSTPPTSPLVTLGNTTFFHVRHGGLWLVAVCKNLDAIKPNANAALVFEFTYRFINLGRAYFGKLDEESVKNNFVLIYELLDEILDFGYPQNSESDTLKMYITNEGVKSDAAVREESSKITIQATGAISWRRSDVKYRKNEAFVDVVETVNLSMSSKGSRARPLRSVDGVTDLLRIARGTGTVLRADVDGQILMRAYLSGTPECKFGLNDKLVIDKSDRPKTSGNPEAVSVELDDCQFHQCVKLGKFDSDRTISFIPPDGEFELMRYRSTTHVNLPFKVQPIVTEVGKTKVEYTIQIKANFSPKLSANNVVIKIPTPLNTAKVDCKVGVGKAKYVPAENVIVWKIPRFQGQSDTTFSAEASLSSTTVLKAWSRPPISVDFQVLMFTASGLLVRFLKVFEKSNYSSVKWVRYLTKANGTYLIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PDP0</accession>
    <name>A0A2X0PDP0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C020g09110 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C020g09110</name>
        <name evidence="7" type="ORF">BQ5605_C020G09110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000082">
        <property type="protein sequence ID" value="SGZ17280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PDP0"/>
    <dbReference type="STRING" id="796604.A0A2X0PDP0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="214"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="625"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="519"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="853"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="9"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGZ17280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="923" mass="103192" checksum="34F3D1B402D40A8A" modified="2018-09-12" version="1">MAATKRKTPTVGSPSSPPTASSRSSTPNTTTQRASRRRSALEMSTSPSSTRPSSVSPPPPQDKAPKPVELDNDSDDNDEVSTGLIPARADDDAPYMPYRQPERGGGGGPKSRNILGDKSALLQTEAVKKHLAQLIEKTEQYVESVSSNFKDFETRPNFFDETIEEKAYNGVPATSLKQRRKLAKAAGLTQLDQPKAITGGVLKDYQSLGVRWLAARWMGIKGALLADEMGTGKTLQTIAFLSFVRAIKLESIQQDPFETFNFHMVVAPKAVLRAWANECRRFAPHLPIIVYDGDKHAREAIRKDALGISPRRKLKPEETPVILTTCACMYNRFGLAPLCADSCIATTVDHARRDANELSKLHYDVLVIDEAQRIKNSTTKTYQRLVGFQSEFRLLLTGTPLQNDLQELFALLSFILPEIFNDVEAWEAQFNFEGLTGEDGHALSKQDQIQVLVAKLHLILKPFMLRRIKKDVERHLPLKKEYVLKCPMTPRQHELYEAARTKDLRALLIKEKTVEKKKNTEIEEDVSGSARKRQKTRKNYEEEDFNEWYDKAMADEVDLTTASDDEDALIESKNKQATSAINNKKLASVIMSLRQIACHPYLIGQPDANEAFYKELVSASGKLQMLDRILPELFAKQHKVLIFSQFTTMLDLLADYFDSKDWGYYRLDGANKPEQEQMDDFNTDTSEDSCKLFLLSTRAGGVGITLTGADTVILFDSDWNPQNDLQAMDRAHRIGQTKPVLVFRLETDASIDSLIIERATRKRKLEKVVLGEGTFRGSMDADAVVDDVLLKTTNKGKRTHKAAGLADSNTKAPSQATIMHDLAERLASTKGETIEFDKLGKVLSDEQMEELLDRSDNAMQPRPSKGSRSKLKKQGRDRTRSGGVFTAVQTIVEDEEEGSPPALMDDLFAVGEAQEVEEDEVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PDU4</accession>
    <name>A0A2X0PDU4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase II degradation factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">BQ5605_C020g09180</name>
        <name evidence="18" type="ORF">BQ5605_C020G09180</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DEF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000082">
        <property type="protein sequence ID" value="SGZ18358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PDU4"/>
    <dbReference type="STRING" id="796604.A0A2X0PDU4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14368">
        <property type="entry name" value="CUE_DEF1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041803">
        <property type="entry name" value="DEF1_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051833">
        <property type="entry name" value="TC-DDR_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16308:SF13">
        <property type="entry name" value="PROTEIN LINGERER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16308">
        <property type="entry name" value="UBIQUITIN ASSOCIATED PROTEIN 2-LIKE/LINGERER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="CUE" evidence="17">
        <location>
            <begin position="48"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="90"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="554"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="787"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="886"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="141"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="347"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="398"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="459"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="492"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="566"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="644"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="661"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="714"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="745"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="787"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="886"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="923"/>
            <end position="943"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="SGZ18358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="963" mass="100426" checksum="8DDDF02B3FECEACF" modified="2018-09-12" version="1">MSSTTASAAPRGRGRGRSSHAPSKSHQQQQHQVHVQDDNQEVARLRSQYKSQLATAKELFPDWSDEDVLFALQEANGDVELAILRITEGHAEQWGSVKSKKTKSQPSAASANNTNRSVSSANPSAADSGWGAEQPASTPAGRGGFAGRGGRGGFEGGVRGGRGGRGGARGGRGGAAGANGTRSASQTNGQPSSSFTSSTPASFETWESNATHAAPAASTSTHAVAAAKPALKVPTWVKKSEPAPEPVIESQPEAEPAQQEQQQETFAEPAATETVTGWGDVSAATTDKADASAETESTTATVGWGDEVPSQPATGGWSDRPETPVVKPKSKVIAPGSKISWAQIARPPSPPKPTPAPPAPVATPAPSPAAAPAPAEAATSEQKPEDAAEPASAPVINLPSSVDSTEAPASTTSGWAAAEPEQQDSAPAPAAAPSASLDPWGTPAPLAAGEGWTDVVVASNETSTNTSTFPEVAAHLPPNDLNAAGPIEISTSAQQQQQPPAAAVEQSQPQVSDSVDNKFGAGPPGLPPKRAQQEAVVLPGATSSEQAPIGVQFGSLSLFDGQPSFGQGHLQQQQQQQEQQQKSEPIAQQQPQQQAQQQLQQQGYGQQYAQQGGYADQSSQGYQQAQQLDSTGAGAFSQAPPNLFGQQSAFARYPNQSYGLPQQYQQPQQQQQPQQQQQQQPQAPQQPSAEDASNPYGVSSFIKNDHSAASPYFQNPAQQAHSPAPQPSAYGASPFNSTASPFGNAPQQAQQQAQPPQQQQSASDYLSFYGGGQDVSRMGFYDAYAQYSQQQHHAQQQQPPSQGVQPTADPTANGTAAATTPVPQPQQQQQQQQHQQGGYGQMMGGYGGGAGYSPYGAYGGYGYQQPAYGYQAGLPQQGYGYYGYGAQQQQQQPQQQQQGGRRGYNNAGASNQLRGYGQGSYGYGAQQPQQHQMQGQPHHAQAGQQGGQAGPGNSKDLDSRGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PET4</accession>
    <name>A0A2X0PET4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C022g09572 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C022g09572</name>
        <name evidence="2" type="ORF">BQ5605_C022G09572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PET4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ22995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="118" mass="13411" checksum="332D3F548F52995B" modified="2018-09-12" version="1">MRYVRLGRRGFAQRMRLVEPQAQRSMGSMPSLVSRLQRTAEQWKLPFLSFYSGALTVLIISGVAHLSRAYLDLRDMRARVSFRRSLSSGRRCAALISSSRFSGKESRNECVNRPSAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PF94</accession>
    <name>A0A2X0PF94_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C008g05398 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C008g05398</name>
        <name evidence="1" type="ORF">BQ5605_C008G05398</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY80477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PF94"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY80477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="156" mass="16931" checksum="0223DCB02D077E76" modified="2018-09-12" version="1">MHTSLDLCRFTPRITSASPTSFTRVVERPLASLLIESTVCRKLLLDSANIQSTPIRTIDLWSDPSVDRPNRQTSTSRSLPIRTPPITTTRKVTIRSTLAMAASTASTVNLPPHSCSVALDSLSPSDLFTMNANPTIDSFSTHLSSSPIDTLHLTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PGR0</accession>
    <name>A0A2X0PGR0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">BQ5605_C038g11721 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C038g11721</name>
        <name evidence="13" type="ORF">BQ5605_C038G11721</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Protein transport. Probably involved in vesicular traffic.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000061">
        <property type="protein sequence ID" value="SGY92184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PGR0"/>
    <dbReference type="STRING" id="796604.A0A2X0PGR0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01867">
        <property type="entry name" value="Rab8_Rab10_Rab13_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000363">
        <property type="entry name" value="Secretion related GTPase srgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGY92184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="237" mass="26059" checksum="AE8E79516F240A67" modified="2018-09-12" version="1">MTNPTYFPLRRTTLFIQKPGVGKSCLLLRFCDDAWTPSFITTIGIDFKIRTIELDGKRIKLQIWDTAGQERFRTITTAYYRGAMGILLVYDVTDERSFNNIRTWHSNVEQHASEGVNKILIGNKCDWSDKKVITEQQGQELADELGLRFLETSAKTNINVEEAFFALARSVHFAISGTLSGQFHSTACFPCLTPACRDIKARLIDTVGTDGAGGSNGGSSNSVGLNEAGGQSKSGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PGV4</accession>
    <name>A0A2X0PGV4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C027g10429 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C027g10429</name>
        <name evidence="2" type="ORF">BQ5605_C027G10429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PGV4"/>
    <dbReference type="STRING" id="796604.A0A2X0PGV4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ28735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="228" mass="25605" checksum="C8C96308DF358C66" modified="2018-09-12" version="1">MSIPVVVLQPIHTIEGVQTHRPQLFNSNWSSLKRVLDLIIRLAREDGAEPSSRINDWIAEQLLNTCLIRVQADSFIVKEMKRTKSAFVASHDLTPETTLFISGRIRNLLSQCGDPPPAEPINCDKDPTASTDVEMEEATPENGSNPEQEQEPGHEKRRIEFLYRSVMGQIAFACNRRNNAMQYRNGLMTLACGANDRLTTFLYDCGLTTSRWATLQAAASLTKENSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PIR9</accession>
    <name>A0A2X0PIR9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C028g10478 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C028g10478</name>
        <name evidence="3" type="ORF">BQ5605_C028G10478</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000080">
        <property type="protein sequence ID" value="SGZ12096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PIR9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016034941" evidence="2">
        <location>
            <begin position="23"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ12096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="126" mass="13304" checksum="7B64D20859049F6C" modified="2018-09-12" version="1">MSRMNTRAVLALVLVASLQALASPITGITFAAGPEQALAVRAPAPAAAATAFNNLARLLNHMMIEPGLAIRAADESESEDTEEAETDDEAEVEETVEEVIERRGNSRVFAMMLSNAQTCSSSVVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PJE1</accession>
    <name>A0A2X0PJE1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C020g09045 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C020g09045</name>
        <name evidence="5" type="ORF">BQ5605_C020G09045</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000082">
        <property type="protein sequence ID" value="SGZ16621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="661"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="942"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="997"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1034"/>
            <end position="1045"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGZ16621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1615" mass="176132" checksum="70CA2B1DFEC63725" modified="2018-09-12" version="1">MRPARSARLSPGPSGEWIPHKYILGIQIRRLEDGSIALSQERYIMDVLARFHFDTTTRGATVPMTPGLSLTAVPGQGTERIRSWYLQAIGSLLYISLGTRPDIAFAVSYLSRFANNPGRRHWVAVKHVLRYLRATYRDELLYACGPTKITGVVGYSDANWGACVDTSISTMGFVFYLAGSAVSWSSKRQTRVADSTTDAEYLALSHAGKEAIYLTQLLSELHVRPVDAAHIFTDNEAAAAVAHDPVHTSGTRHIRLREHFVRDMVHQGDISLSHVGTANMVADIFTKALGPKIFGVHCYALGLRTRHPRLKSTSRSRGGGRAGRIGSGLRRAERARCIGPGLGARSEPGKLGGARLSHLELIEYFVADQGDSTAMPSATEIFTRLYRDVKARPVDTPVAAVATPQARHGCSRPCPNPSCRKLHWLRECPDTAWAAAYRARRTAEKKASQPVASPAAVDTPNSVSFTACLLATPSPFRKSAWLLDSGANRHMTNDRGLFSELRTVAGPQVGGVAGSLPSTGCGTICIQTSTGPITVSNVLLVPDLPCNLLSVFQLDQLGYRVSFASRCASIARPSGAVVATAQAIGNNLYALALGPTPCTPKALLAIPANVSLLTLHRRLAHLPVAQIKNIVQSGLVTGVDWVYKDQELRDFYCNACLASKAHALPFARSKSIASGRLDLLHVDEAQMPRPTFGGHRYMLVIIDDFSRKHWCILLALKSDVFPRLRDWILEVENATSNKVKTIRSDNGGEFTLRNFVDFCASKGIRRELTIPYTPQQNGRVERSNRTIKEGILALLYSSGADSRLWGEAALYYVHCKNLMPHAGIGGEIPDTRWHGFAPDISTLRAFGCRAWHHLPSAKRTDLDPKAVPLLFVGFDQHAKAFRLFEPSTRRIQLSRNVVFRESEFPALRPATDVRAEPIPLPVTVDAYPDQVDPLEPSLVASPRSLAPRAEPPRPVPAAPDQGPHRPAPAREVPDQDSLAPPAPDQGSPARELPDPESPASSASDQGSSDSAISTPCPSPRPVASRALPAPPSPARSDSPDPIDLLPRPRDVASLCQAQGFPDDVDDALHSPSAVAYLASGAAALIETSPVDPAELIAPARDPPHWRAAMATPQADEWRLAARDEFDSLLRDFSAFTPIDESLVPADAKVLGSRFVFRTKRDQHGQVKSYKGRLVARGDSQRSGINFDETFAPVAKFTSIRALLALAAAHGYHVHQADIDKAYLHGKLDAPLYIRVPDGIYMPGKVLQLHRSLYGLRQAGRIWNDEIDSALSALGYVATGSDHCVYVRTTGDVHHYIALYVDDLLMISPSLPEIERTLQGLEQRYGVKRLGEAEYVLGIQIRRSPDGSISLSQEQYLKDVLARFGMSDAHPVATPMPPDLRLEVELQPTPFPDRTRYLQAIGSLMYASTGTRPDLAYTVGYLARFSHSPSAAAWGAVKHAFRYLAGTLSHGLRYARGNPAPLLGYSDCNWGACVLSSKSTMGYTFVYAGAAVSWSSRLQSRVADSTCDAEYLALSHAGKGAIFLRQLFGELGLSSSKPVLIYGDNQGANALTKNPVFHARTRHIRLREHFVRDMVSMGDIVVQYINTGEMTADIFTKALSRDLFARHRGRLGICAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PKI5</accession>
    <name>A0A2X0PKI5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C022g09557 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C022g09557</name>
        <name evidence="2" type="ORF">BQ5605_C022G09557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PKI5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016013244" evidence="1">
        <location>
            <begin position="24"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ22892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="127" mass="14334" checksum="FA5276082FD6B2FD" modified="2018-09-12" version="1">MVPFHLLALIAVGLAIQFLSARASFDADCKTYADQKAPSLIKGLPNCTELSQGLSDWTYKQDQYDAQCLCANDQWYSHYDGCLNNVNHKLWGQDIAKDRQNRCKECFGYYRDGLRYDGTGNPHSESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PMD2</accession>
    <name>A0A2X0PMD2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C027g10334 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C027g10334</name>
        <name evidence="1" type="ORF">BQ5605_C027G10334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PMD2"/>
    <dbReference type="STRING" id="796604.A0A2X0PMD2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37331">
        <property type="entry name" value="YALI0F11671P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37331:SF1">
        <property type="entry name" value="YALI0F11671P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ28428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="227" mass="25510" checksum="DC39C0FAE901D402" modified="2018-09-12" version="1">MLALPRATATLRHVPRSTPSISQYQLWHRRHSSSTSSTSSSLESPSYPGLYYHSIPSSSPPSYTLSFLPTPAPSPTFSPTTIGTLRTTTTSLKGNELLPDPTPRQFKDNPDFSQVLQEIIKEVILKKGNKVLETMAKTRPEDGWIHITDQRTQFDVLSRVPDPSDIIASLLVQNREIIRESYQPSGTHRLVTIDGMMKLEQELFEAVKEKLGRVRAVEEEIAREAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PNI2</accession>
    <name>A0A2X0PNI2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C049g12440 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C049g12440</name>
        <name evidence="3" type="ORF">BQ5605_C049G12440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000111">
        <property type="protein sequence ID" value="SGZ30714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PNI2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="58"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ30714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="335" mass="37226" checksum="0EBAAC5E78911594" modified="2018-09-12" version="1">MPFPVTIDSTITVPRSQSKHRRSALRQAPATSGTLSATDGAEDLDRCAGVGTSSRLVKLNDDLWLHILENIPARELTRLRTVSHDFCAKISHLLRARFRHLACSKQYEVLFESCAPTATRRNLRHRVTFSSFVSNDPSSSELAEFGFTGSTTASQSITLDDDQAFGNNILALHIRAVHASAKTPLLLEAPETWRATSSPPTLESYAWTMTVANGMNRVFRSWFERPDIPPPSPPSSPEYDSSDQETSLAARPKAIKMLKPALRCAIHSAQIQCHLVHGIARDPRVTYQTLPGALPSRFESAYESLKVDVARLVVGVEEGIRRSGHKERFLMWLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PPX1</accession>
    <name>A0A2X0PPX1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C062g12755 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C062g12755</name>
        <name evidence="2" type="ORF">BQ5605_C062G12755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000138">
        <property type="protein sequence ID" value="SGZ35541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PPX1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ35541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="536" mass="60529" checksum="442F5383B147738A" modified="2018-09-12" version="1">MMNVFYKKKKATAARPGATTRTELASGRDCAGAANGAGGESFKWCGYAFFRHGDSKLFWTHVLDRIKAKARAARDRTLSPSGRVFYANAHITSTVLHVLSFDIPPQWAAAKTVARDFVFQAREDGGLGLISIGDIVHSVALRFWDAVAGSDEAIWAPLARESWRSLVAATRDFSPWGFFSSTARVEKLYRDSTRWGQSLQRQGHLPTIKSELLTLPELLSLPPRLPSLYAEGAKHAYDDADAVAKFAQIADLYWRDEGKGWALVGHRRGFWQHSKEPALRHEHVWARVGQKLKAKALLPKTAVRPARIPLKEDPHPRCFNFFGLTRPFTIRKLRRLVNTVRFPGKDGQDRALPGGQPQEPRVKRFPEGTSQSGRQRFWSWLHDRFASAAEQDTHWRLMYDVTPTRKKQHVQGHASSPSCLFCGNDAAVIETVSHYFFGCAYSASYWSGVLRILFDKLGIEDTDVDPSTFTQEQLTMGLPLLRGRGRTTSKWMWFGWLRFEKDRVVAPPSIPSALRAFNRDYLSRAGFVPGARDWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LSA1</accession>
    <name>A0A2X0LSA1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C011g06381 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C011g06381</name>
        <name evidence="2" type="ORF">BQ5605_C011G06381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LSA1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301:SF10">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="156"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY12080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="456" mass="51710" checksum="4AFDF10046AA0F49" modified="2018-09-12" version="1">MKRPRLLNPFKVEIPSAIERLLSLNLKFIIRPKINVVAPLESFKELRTTVRRRSRFLNAPVKTGRDRYVPGLHVKSTLPYTWPKADETVEKGLDRGFLLLRQALDSVDSTRWRPNLAGATLPSLEGFMNSNNVLEKASLQTFSLASLYQYTPFSAEKFVHQLNEDQIQLPEFHMLPKMHKVKLAGRPIVPSHSWVTSHVSKYADWLLQPMLQLFPWIIQDSKDLLRRLSDVELPEVNEELWIITADIQSMYTNLPSDEGARCMRWLGTHFYTQEHLPFSQRLPPILAPMFEDFLDSGSENFGFGSAPSSELFNTETLREQTAGDLIYELVSFVLNNSYLGFQGKLFHQVSGTAMGTALAPTYANLFVGALEREARLLETPNLIFYGRYIDDVIAIVKGPRSNVDICISALAQLHPSLVFDAEVSSNGLPFLDAFISKNSDPKNSSRWSLSTRVLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LSP6</accession>
    <name>A0A2X0LSP6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C012g06908 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C012g06908</name>
        <name evidence="2" type="ORF">BQ5605_C012G06908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LSP6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY16553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="190" mass="20140" checksum="E7456529F313F0D4" modified="2018-09-12" version="1">MALPAANLTTTEDLSKKTSPSIRVFKRNHDGELLTSGLDQGGVRKDHFALAPVGSGQACQRVPRRADDEPGPAVFSETNWMLFAAFPAVCLATVLCSVQEYRCGLPGPHRPTPPSDLSVAFDAVIHYPAGVSSRGLRGPRVGSACAAQVAHSHTPALHNTVGRQTAGKAAKSIRLRYAQSCCSVLGFYNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LT29</accession>
    <name>A0A2X0LT29_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C011g06352 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C011g06352</name>
        <name evidence="1" type="ORF">BQ5605_C011G06352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY11999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LT29"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY11999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="63" mass="7429" checksum="2ED3DD2A0EBB3202" modified="2018-09-12" version="1">MRCRGRCEDRGLTSGEDGVVQPTCCFQKKSERHEIALEPHWFRVQTERIKRCNSQAKKDYSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LTR3</accession>
    <name>A0A2X0LTR3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C010g06058 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C010g06058</name>
        <name evidence="8" type="ORF">BQ5605_C010G06058</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LTR3"/>
    <dbReference type="STRING" id="796604.A0A2X0LTR3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="16"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="53"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="115"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="65"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="141"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY14095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="827" mass="90833" checksum="F57534715EE8C9E8" modified="2018-09-12" version="1">MPDVELDRSQVPLNEACVACRAVKRKCTHPGTGAACIRCERLKKDDCTFKQQKRGRKRIRPFEGSFNSGGDSAASAPSMSETTVAESIQASQATQDVEAKLTTSYPSPSTYYYLKLGPTSNPPPQHIPHAGLSSHAHDRTAASSNGGSASASTSRLEQVSAPERPPSSSRSTASGSDTYACPGVSPTNVPDDFVEPPVPKPSIPRTLGLALDRLLAHDDPSEGSDTMDIWSFANAFGHKKKAKISAVSEDAGFGMLPPRAKDRGTEVLDVVQVGVIREEQVEELWIHFFDHLNPMISILDPVLHTSRFCRSRSAFLYSAVLTVTAKCVLSEDVYMNCARHLNWLFGKAFEYGTNTLEVIQALAISLQWPHPTPRTLVRRNSYMTRSAIEIRLYTKAPRPLPQDDLQVRLILNRERTWMCLVVADGRVSAQHSLPRLIKPEWLWDAIQWYLENRNRGGLATDTLYCPLVGFYPMSDLHCALMAAIAEEKAPDPSVLACLETTQKNWMQLWAPEDEHSTMLPLSPPIASLCRFLAALTKFQTDEVRLLISLVKAKEMGEPERAQDPSSAPVLDFARCVRSAHSVLLQLVAEVTRIRYPFDSMWIGVASCGIWLASNYPNMRHDQKTQTMDALKQALEATKAFDRGWASLPIYALHLLNQLIRGIEATATPPSEHNSNVEILPAQQSLPNQQPALTVSGADVQANFPASSSNLLSPNIAFEPRFVPINYVPMSAAQPPGWEIPLLAAAANCFDYRVSSTNPGVAAELIPRQMAMDPGLPLPMQPNAYYGPSSRPMGGAVGEDAGWSALPPPQEEQSWYVQMFARLASLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LV42</accession>
    <name>A0A2X0LV42_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C013g07330 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C013g07330</name>
        <name evidence="6" type="ORF">BQ5605_C013G07330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LV42"/>
    <dbReference type="STRING" id="796604.A0A2X0LV42"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03484">
        <property type="entry name" value="MutL_Trans_hPMS_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.100:FF:000001">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000017">
        <property type="entry name" value="PMS1 homolog 1, mismatch repair system component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="entry name" value="MutL, C-terminal domain, regulatory subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF52">
        <property type="entry name" value="MISMATCH REPAIR ENDONUCLEASE PMS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="5">
        <location>
            <begin position="226"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="4">
        <location>
            <begin position="694"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="405"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="547"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="440"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="551"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY15332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="914" mass="101150" checksum="413D12B5248C8BCC" modified="2018-09-12" version="1">MEDLLENPRAHNMHTAIDHTSVHRLTSGQVIIDLQSAVKELLDNALDAGATSIQILFRNHGTELVEVQDNGQGIEEHDWASIALKNHTSKLSEFNDLGTISTLGFRGEALSSLCGTADLSMITSTPSTTPIATRLTFLPSGECVVGGKAARSVGTTVMVKDLFAGLPVRRKEFERNAKRELGKALDLVQAYALVRTGVRFEVKHTLKGKTTTHLQTTISQNLRDNFSSIFSPVALNDMIDLDLEFEVSAEQSARAISRGLISDGPVRVMVRGLISKPAPGHGRSINNRSFYYVNGRPFTATKISKAVTEVYRRFNTNAFPSVVADFQMRADAYDVNVSPDKRTIFLHQEGKLIASLKDALENLFSPSQSTYPITQPQLMVSAKEIKSDRLEVQLFKQVVDLLPPMPTLPERSNLLDGMSEDEEESLPQVERPSKRSRIVEEEEDDDHDDEEEAEVVPDEEEMEVDDEPISTQEEEVDELSLLKDDLEGSPVPSLPAIETSESSERAVSEEEEEEHVPASSNFRGSTRRTVVKTMDLSSWVVKIKANEPKSSRQQGRTLATGNGGTRVGRAASPDEVVDSTRSDYRTQSITRQLKTTQGVRAQNVVAKVDYEGVKIKNMSCPTNFSKITQAWKSARPLTSDLRHSQPAPEEAEPARFDGEKTIDLSRAGVNKDSEQAEQALSLVVTKQDFACMSIIGQFNHAFIIVRRTRRSTSSGGDKTPIPLQDDLFIIDQHASDEKYNYEDLQKSTVIQSQRLIQPRTLHLLAQDELLAIEHAKTLRLNGFEVLLDEDAKVGERVKLVAQPVSGSTTFGVSDLEELLELLKGSDWSQDGHAPRPSKVQSMFASRACRKSVMFGHALNEAQSASIVRNMSQMDRPWSCPHGRPTMRWLSRVPQALGARGDARTDVSTLVGSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LXX1</accession>
    <name>A0A2X0LXX1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">BQ5605_C014g07573 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">BQ5605_C014g07573</name>
        <name evidence="15" type="ORF">BQ5605_C014G07573</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY19149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LXX1"/>
    <dbReference type="STRING" id="796604.A0A2X0LXX1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008053">
        <property type="term" value="P:mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051646">
        <property type="term" value="P:mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000638">
        <property type="entry name" value="Transmembrane GTPase Fzo1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027094">
        <property type="entry name" value="Mitofusin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465:SF0">
        <property type="entry name" value="SARCALUMENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465">
        <property type="entry name" value="TRANSMEMBRANE GTPASE FZO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="14">
        <location>
            <begin position="272"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="134"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="676"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SGY19149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1010" mass="109053" checksum="49F5B035993A39F1" modified="2018-09-12" version="1">MAQHSLPHSVSHARSRSQSSQSSQHSTDGFPFELQSPSSTQFGSMPSTPKSTSFGGTVASPSVRGSTATSTTLSGSVFGVTKDDMARHLDEQASFATKRETLVRSLDSTTTLVKSLAAFNQEKWTIHYPHQLGVDATSNGSQRDPLVTPVRSSSARLPALRRSATLQPSEGAADDSPDEHSASPKRPSSQRAWSTVDTPSNTTAPASTSSLVAPAHPLSILSLDLKLGHPAAATAALPALLPSLSVATLSQLLSRRLTSSLTHISSLRSRVVDTNSRILVTGDLNAGKSTFVNALLRRDLMPSDQQPCTAVFCEVLDASNFNHGVEGLHAIRDIGAYDPTKPETFDSFDLTQVQEVQDAEEPYQIIKAYVHDNRAPAVETEPNPSFIKNGLVSISLIDAPGLNRDTLSTTALFARQSEIDVIVFVVSAENHFTLSAKEFLWNASREKAYVFIVVNKWGAIKDKARCMRLVGQQIKQLSPATWEARHELVHFVDAADVVESDSAAPAQVTVVEDCKFAEENGDEKEPTAFDLLEQSLRSFVLLKRTTSKLAPAKNYLLNLLADLSTLVETNLTAASDQLAEALRQLERVRPIHERLSAQRDEVEAGVDRVEETAVEAVRSSAWSRLERALGYVAEGQVVPPQASDANRRRFEDADQLVAPTSLPEYAGLVGLWDWANEVKKTLVKALEAEVRIAEDEARIETSAGVEQVMHGLGERYLPSAAVEERTAIAAQDGQDPVGGHVAAATPKKQDRVFRPEVMFAKRRRGIGRLAARGVSTGLGLGTGATGLSSTSWSATDFEVSIFDLFDLERLYSHGSRLRGKKTPDDDLVETSTILGLGVGTIGMLGSRVIGVKGTMDSITRIFEVLGSDKAKKLAAPILGLITVGFVTYVIVDLPRAIPRNIGRKLQASLASSDALVLAPSSASAASTTATQPPVSFASAHSERIARETRKVLRLAGWDLRERFRAALDQSAAERKEVESTVNKTEGALKWLAEFENKVAQEDSKVESVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZ64</accession>
    <name>A0A2X0LZ64_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C016g08074 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C016g08074</name>
        <name evidence="1" type="ORF">BQ5605_C016G08074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY20489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LZ64"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY20489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="55" mass="6549" checksum="EB76E113C7A35EB4" modified="2018-09-12" version="1">MSKYEGHLVLNNSSKLLYKLYIAQFCAVRRLRSRRARAGKVARAHQERRQRAFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZI2</accession>
    <name>A0A2X0LZI2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BQ5605_C017g08494 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C017g08494</name>
        <name evidence="12" type="ORF">BQ5605_C017G08494</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:35603"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:138881"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>beta-D-fructose 6-phosphate = dihydroxyacetone + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:28002"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY20152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LZI2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10880:FF:000005">
        <property type="entry name" value="DUF89-domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10880">
        <property type="entry name" value="Uncharacterised protein PF01937, DUF89, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039763">
        <property type="entry name" value="ARMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260:SF4">
        <property type="entry name" value="SUGAR PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="AF1104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Damage-control phosphatase ARMT1-like metal-binding" evidence="11">
        <location>
            <begin position="169"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="28"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY20152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="613" mass="68583" checksum="DF8D51AA815E208A" modified="2018-09-12" version="1">MLPAHQEALARACPPASSAPVTQTTCRTLSLPNSPSRTSHVGSLALPSLQSSSPKTPHLTKQLGSSIAATKMSLQVPSGNPGSGHSAGANVPKKVGLVLQSLPPRNETGFGKPLHPRTPSNISLDHPPWPAYRGYHEYSFAHVSTCRVQAKNKSLKRILNSLFCFLQATMSHRLPTILAKAIDDVRTTLNEQYEEEKIVDLVECMERMEDLMDDLQSNATLRPIIDDGEGDIPLWNKEIAKLDVDPQCYRGKDFMNAPWLFAEAYKYRRLHECFSLSKFWKSYDVFFQCETFSRSGEAVFELSTRFADPYVIDEKLSAEDQLKAKKLIFHELTQVALWGNATDLSLLINMTEDDIKNLQSTGGDHLAATEKNILGNHLEKAWDLISSPNFGNGRKGGRIDIVLDNGGFELHCDMVYADFLIQSGLASQVRFHGKRFAWFVSDVTRPDFDWLINQSVYGHLFPDASEDQVASLRLMGQRWQKYVKEGIFVYEQHPFWISGWTYWHLKREAPDLFLHLADSDLVIFKGDLNHRKLTYDCHAPHDTPFDVAIGPLGSDAGAPPVLTLRTIKSDVVVGIPAEEGARLDKEEPGWKISAKYAVVLLSEGHKGEPIDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M2X7</accession>
    <name>A0A2X0M2X7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">BQ5605_C002g01592 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C002g01592</name>
        <name evidence="13" type="ORF">BQ5605_C002G01592</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY34124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M2X7"/>
    <dbReference type="STRING" id="796604.A0A2X0M2X7"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16485">
        <property type="entry name" value="mRING-H2-C3H2C2D_RBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000010">
        <property type="entry name" value="E3 ubiquitin-protein ligase RBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="63"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGY34124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="129" mass="14444" checksum="18DE98B9B5E1E766" modified="2018-09-12" version="1">MEVDSAATTASGATKDNAPANASSNHTAQKRFDVKKGTHVPINLVSQWNAVALWAWDIQVDNCAICRNHIMDLCIDCQANQASATSDECTVAWGICNHAFHFHCISRWLKTRQVCPLDNREWELQKYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M2X9</accession>
    <name>A0A2X0M2X9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C002g01541 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C002g01541</name>
        <name evidence="3" type="ORF">BQ5605_C002G01541</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GID4/VID24 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY33760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M2X9"/>
    <dbReference type="STRING" id="796604.A0A2X0M2X9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045721">
        <property type="term" value="P:negative regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018618">
        <property type="entry name" value="GID4/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534:SF3">
        <property type="entry name" value="GID COMPLEX SUBUNIT 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09783">
        <property type="entry name" value="Vac_ImportDeg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="318"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="358"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00061469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY33760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="687" mass="76430" checksum="87749088A1584587" modified="2018-09-12" version="1">MDRSSQAGPRPSSSPSSSDSHSHSVAAPPVTEVTATALYPAWPHRAALPRVLTIHDPGSIATSDSAMVSTSTSGNPSLPPWAFDDPSLQAEPRHSQQQTHRMDEPRRHESRNGEQSAHDTGQPQDRSHQAMYRTLRLAETLRRRAAAQGRTSTRPELSFRITGMDAPSSFSMAFDDHTYEDFSNMDDGIELALPSGLDLDDDRDPEPRYDDDNPLHNWIPDPEPYSETDSDADEALFWPGLLIERPLNPPGRSLLRRSLTRSMLDRVSPCLLEETSGLGSGPTPALDPDSSTSPSSFLKRGMFFSGIQVYVVPLPPPIPAPATPTSRTERRSSHPRPHRQLAASTMDVYESARALAEGVNRTHQNPTVSRSSSLLPPARPSAQPPFAESSPLIQLLRSANRLDDFVNHSSIEEAFGSFPTEFSPGHATATATTTTNDGVSDLDLSPFARARLRTEQDVREIRERTARVARARSVTTTGTWDLLRLAELGETLSVSERQKYLEHERWEVKQWWLTVLSRLPIQVIIESIDFTMNKITGYMHALTVPFSASRVTTCFTGEILNLAKDGLWSPGHWESKVRIDAESWSKLGPFKGMKTNELIRKADGDRQWLNQVTRGHVLMRWKERDFVNVTPTESHLSIAGFYFIVLDRGTGMLEGLYHDPTSSPYQRLELSPWTQGLGFSTGTFEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M3P4</accession>
    <name>A0A2X0M3P4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C002g01630 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C002g01630</name>
        <name evidence="1" type="ORF">BQ5605_C002G01630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY34436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M3P4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY34436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="41" mass="4678" checksum="8136511BF5159718" modified="2018-09-12" version="1">MAKSAVRVRVSYETLLQNSDFGTLESIWYVETLQHQLTCGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M489</accession>
    <name>A0A2X0M489_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C001g00743 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C001g00743</name>
        <name evidence="5" type="ORF">BQ5605_C001G00743</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY49151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M489"/>
    <dbReference type="STRING" id="796604.A0A2X0M489"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056337">
        <property type="entry name" value="LHD_YVC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF1">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23190">
        <property type="entry name" value="LHD_TRPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="355"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="514"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="571"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="YVC1 N-terminal linker helical" evidence="3">
        <location>
            <begin position="150"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="4">
        <location>
            <begin position="330"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="676"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="682"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="699"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="775"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY49151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="846" mass="92640" checksum="BDC816906BDCB59A" modified="2018-09-12" version="1">MVSIKSAGYAFSTANAASTTSFAESTGSTAHTTGMTSSLVDSSVEDSSHPHPRSAASIQHEENMPLLGNSRTLQEIAEEPVFPLVHRVASEIVDVIVSYHSKSSSGIPSTQLGPSSKQDTVLSYDQLKSPTINFSLVRPLTLKLSRGDRPPSPLIYALLVCRVHFLAVASDDLAFLALNTTRADLCELLAVKMLSVYGNQPTSYDLLHVLTASFNPYQGATQDMFAQSEGVDENELKRLYEWGQRQRENALELGIFSEAKRFVRSPLVQQVVRAIYKGEVLYAPPASRSIIKDDYKAKPVVTIYDWRTQPFLDHALLRVPQIRNRLEFFSFGCLMILFLVTLLTHSDTHIKPVEALFIFFALGFALDEFASVTENGLTTYSLGAYNVMDAVFCAIFFLFLGMRLHGLWIGDEARSEFAFATLSLGGCILFPRLTISLLRDNVVLLALSAMVQQFLQFMILVAFTASGFVATFYVLAKARGAEQWDVGHISWLLLKIWLGNSFLGFEAAQQFDPYYGPALIVAFAVLSQTLLLTILISLLSNTFAAVQGNAETELLNQMALRTIERVKSDALTSYVAPLNLVAFVILYPLRKIATPRYLHKGHVALTKVLNLPVLLALAILTRARHHQRGFFFSFASTSKRVWKALPLSGSWVGWESTVDGVGNIFEREVTSLALRVESIDKGDEEEENGEGEGEGRGRGATTTTTTTTTTTGDGKTTPTSTPKQPTNGQARRSESPRSRQVGPSKRNSRIGSLQSPLARMFDVTQGQTVGTKSGFKRDEETKGDAGKSVGGGGGGVKEDREITKRLDAIEAALAILVGELVKNSEGSDEVKRPPLTSFDWCGRAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M4H3</accession>
    <name>A0A2X0M4H3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00860 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00860</name>
        <name evidence="2" type="ORF">BQ5605_C001G00860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY50170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M4H3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="686"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="417"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="495"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="536"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="566"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="690"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="791"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="808"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="820"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="843"/>
            <end position="875"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY50170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1030" mass="108631" checksum="E1BDE46FDDF53344" modified="2018-09-12" version="1">MSRFLTTWEAPVATGSETPAASSSLRGSAPSSSSPTLVAAAAVAASRPARSPLRPSRPFLPSTFASPALSSSASSASTSRTYSGSTALSSPCNSPPTVPAADVGLPLGPSAPAPRILGVETAALLSLPPASVESTMRLPTQVVTSNPVSYYDSTASTSDDEQHDQSRATRRSRNRRAHASAGPSSTVQTIFEGPFRRASYEVLPGAPSTSTSANGTPQYGSLEQARGYGRAGTWPSVPSRRLSQQSDAPRTSALAQLNVNNAQKDISPEGLGLQNIEYGVEGRSRRGTGEGYDGRNSYVPVSGETAFSSANESYSSRSPAFLQPSPTSPGEGRFPTTLPGRGSPTLGSGPSHTKVARPSPVRPARSTRFLPEQVHKLERGRNNAGSASEPRHPNGSGSSFRSVELQPDHIVFPDSAPVPSQTRRSRSPSSIMSRRSGVLPANAFASLSTTSNYDSGLLEYSGRPASIKSVCSSTAATEFESHRLYFPPPPPKQSPNPASNPSLVFPSAPRRAPRSPDATQNGGPFPGRPRASPKARSPVFPSASSPVSSERSVRTSALPFLGPALSFSKTSPTKTSSPFPLVLAPSLQSDPDSGPEDELDQMIRAQRRGVSTAQAPRFASTVRTPKETNVYDDLLGEVDKVELKVAAVNLGRTVPTSSRSAAPMHAVPQSEFLSAAFEEALAAPHRHQRTISGDTVASDSSADYFDANEGSISPLRSSESSDGDGKHQNGMPRTGHSTSACDQLRRMSAIGEEAEEEAEEGDRRNSILTLRRRSSPRNSKNLSILPPPIDENVRSSEPPRDAQSMLPKTPPRPPPPSLPLSPALSSSSPSSNVLRNRDLAHSASVNSMRSMPSTLNRTLQTPGRSMYSLSNESSVSTRSYAGSVAPSTWSTRSITKRFGSFLSGTSSTSSSPRTKSFSAKNGQLNMVGISSEAIRAAGLFQDDGPELLTGEGDPQASSTQGLMPCLPLLEHGNGASSSRLNLYKASEEVTQLEGLFARFEREEKERLKSITAHRTRKASAPAVVGIASVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M6E4</accession>
    <name>A0A2X0M6E4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g04246 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g04246</name>
        <name evidence="1" type="ORF">BQ5605_C006G04246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY57258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M6E4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY57258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="66" mass="7642" checksum="F80479996553363E" modified="2018-09-12" version="1">MENYQAAVSFNTSSLNVNLESFFFTIGWPATTKARARAFRSGPTQFFAEPCLYRINIDESFYFQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M7S1</accession>
    <name>A0A2X0M7S1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Signal recognition particle subunit SRP14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Signal recognition particle 14 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C001g00537</name>
        <name evidence="9" type="ORF">BQ5605_C001G00537</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of a fungal signal recognition particle (SRP) complex that consists of a 7SL RNA molecule (scR1) and at least six protein subunits: SRP72, SRP68, SRP54, SEC65, SRP21 and SRP14.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SRP14 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY47501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M7S1"/>
    <dbReference type="STRING" id="796604.A0A2X0M7S1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.10">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, srp9/1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003210">
        <property type="entry name" value="Signal_recog_particle_SRP14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009018">
        <property type="entry name" value="Signal_recog_particle_SRP9/14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12013">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 14 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02290">
        <property type="entry name" value="SRP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54762">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, SRP9/14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="37"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="113"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY47501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="199" mass="21712" checksum="6C4F46FE8489ACD2" modified="2018-09-12" version="1">MSLSNEEFLKQLADLFESRKGSKGSVFITMKRMTYTPPGEDVTMTNAEAEEPQEGTSAAGRSSSQQQWPCLIRAMDGKGKETKRKISTIVAPEDQATWSTAYGALLKASFSTLRPKQKKKTKKVKATTTGAAKGNSGKEGAGTTTSSTAGKGKKSTVQPSRVLTKITGARRGAGVSKRRKLLERRKRELKRAWARRRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M804</accession>
    <name>A0A2X0M804_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C001g00628 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C001g00628</name>
        <name evidence="1" type="ORF">BQ5605_C001G00628</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY48210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M804"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY48210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="55" mass="5722" checksum="ADAEFFA39ECACB2B" modified="2018-09-12" version="1">MRSKIGDFPGFYLRASGWVFMGPVSGGLWQSQAVRRSAPKCAAGRCAGDAGTGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M8I3</accession>
    <name>A0A2X0M8I3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C001g00857 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C001g00857</name>
        <name evidence="7" type="ORF">BQ5605_C001G00857</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY50105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M8I3"/>
    <dbReference type="STRING" id="796604.A0A2X0M8I3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19677">
        <property type="entry name" value="UBR-box_UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040204">
        <property type="entry name" value="UBR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047506">
        <property type="entry name" value="UBR7-like_UBR-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13513">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13513:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="6">
        <location>
            <begin position="48"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="4">
        <location>
            <begin position="48"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="230"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="271"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY50105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="454" mass="50732" checksum="E66FB1C8D709BD6E" modified="2018-09-12" version="1">MLSREVLLFSPTREGIPSSDDAFSAQDLVAAQDALEAEARDTIPFAFTECTYEMGYIKQPLYACLTCLNHRAVCAACSVSCHGEHHLVELFNRRHFRCDCGTEAMGAGSVCEVTNRKDAPKNNENRYDKNFLGKFCVCGKDYDPHTETDSMYQCLICEDWLHHACLIGSHVDSADSLLATDDFDHVLCDTCVRHDYKGVRTKLLDRYAGIEGSGVMLLDMKTKAIIGRAALDDGDENENENEGQGRNKPDVNEEGDLSEAKPHASSGDATDQDRPTKRARLDELTAKPEASSSSSSAQHDIIKRDTVTDLPTKACKAPLRPSPSDVSPLKRLELGGGKLNVFFEEGWRMRWCQCQECSPLFADFPYFLEEEESYEPPDDPDAHKSTHELGMAALSRMPREQAIEGAIAFQGLSERLKNYLRPYSESGATVTKELIDEFFAKEREVLLEQMQQNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M961</accession>
    <name>A0A2X0M961_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mannan endo-1,4-beta-mannosidase</fullName>
            <ecNumber evidence="4">3.2.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C004g02893</name>
        <name evidence="13" type="ORF">BQ5605_C004G02893</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random hydrolysis of (1-&gt;4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.</text>
            <dbReference type="EC" id="3.2.1.78"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.78" evidence="4"/>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY68509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M961"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045053">
        <property type="entry name" value="MAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451:SF39">
        <property type="entry name" value="MANNAN ENDO-1,4-BETA-MANNOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26410">
        <property type="entry name" value="GH5_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015856934" description="mannan endo-1,4-beta-mannosidase" evidence="11">
        <location>
            <begin position="21"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="12">
        <location>
            <begin position="129"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="71"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF26410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGY68509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="526" mass="59389" checksum="ED0C9FF3771C4356" modified="2018-09-12" version="1">MHGNYLRLLLGSILICQVIAKWYKYDTGDHRIPRRHRRVDLRGRHHASGVLGGDFSSNIETANQTIQIDELRQTTDTKGENEDLQVSDQEGNGSSLDESDKASNGRIIISGPPHYVNPAVREKYLRIDMRSKGFTLDEEPFRVVGINIYWLCNDENVLGVKPGTPTQKRRIREALAAAVAMGANTVRVGSCGISLGYADALQPDQHHRAAPRSPAMDIHDYAIYAAGRYGLKIILPLMDNYDYYHGGKYTVLKWLGISAEHNGANFFTDPRAIAFFKSYIEFVLNRKNPYTMRTYGEDPIVSIIEDGNEFGAYKGSEGYPPLAFTDEIAAQVKKFAPQALFMDGTDGFFNLTAHLQAPGLRSKAVDIVTDHPYPRDIPLLQMQAFLARISGKAFILGEMDWVPSAPSRNPPPRLVEPSLSAYLNVLDRYPNSKLPLRMRMVRPVLSRILTCFNLAVGVLAWSLFVHTDDCRDWVRHHDGYEMYYPLPQDTAEKQANVLTLVQWFYARTGREVPSLLPYQMCPQEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M9N7</accession>
    <name>A0A2X0M9N7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C004g03043 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C004g03043</name>
        <name evidence="2" type="ORF">BQ5605_C004G03043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY69644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M9N7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY69644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="70" mass="8059" checksum="16692F985A26F21B" modified="2018-09-12" version="1">MDIWGIKAFYARFIIKVFCIRQLMRGPTRHSNKGYTDNEGGDAEQRHAEAKTRFGLARQQSQVSKEFVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MAK7</accession>
    <name>A0A2X0MAK7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g04263 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g04263</name>
        <name evidence="2" type="ORF">BQ5605_C006G04263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY57368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MAK7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY57368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="55" mass="5823" checksum="EABCD2A4656CB848" modified="2018-09-12" version="1">MAGPAAPETKLATPIKRSALNVELDVGDTDSEDSELLSSPPTKRQKTIDESSVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MAS8</accession>
    <name>A0A2X0MAS8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C005g03422 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C005g03422</name>
        <name evidence="2" type="ORF">BQ5605_C005G03422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY75372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MAS8"/>
    <dbReference type="STRING" id="796604.A0A2X0MAS8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47369">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47369:SF2">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY75372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="442" mass="46687" checksum="4141AB49126322EB" modified="2018-09-12" version="1">MIFGSTQSSPTQTELPSQSTSSSPAGPSSPVASSSHSHPRSHSNSQTAVPTVAAPSYASSNAHVPISTTLDQHAPLTDHLFIAGWTNALFSDTQLTVNYAAMRHSPSTFHLHAIIVSQSPLLRSQLEINYPHRPLHLNSPDPEIDPESVSLVLASLYNLSILTAHLEAKNAISVLAVAYWLGLDSVLKRAEEQCRTSVRFVKSKHDFANWYRALGILSGSDVDDAPSSHGHGHHYQHHHHTSSLGAGVGSSSDRSESRAPLASSNGVTFTGLASPMDPNTSLPHGIDGASRLNGHANANGGAANGSGSAQLKYGAAGARLKVELGRRLLDLPNELNAFPPAGSSSTGAYDELVDLMASLPFEVLKTALESTSFKIPGGDLQRFSLGQKIVAARRSFAASAGRPPVWEENVVLQFGANGTSSSAVGLLRKRKVRGSWKVSDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MBX0</accession>
    <name>A0A2X0MBX0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Casein kinase II subunit alpha</fullName>
            <shortName evidence="8">CK II alpha</shortName>
            <ecNumber evidence="8">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C007g04714</name>
        <name evidence="10" type="ORF">BQ5605_C007G04714</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="8"/>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY62617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MBX0"/>
    <dbReference type="STRING" id="796604.A0A2X0MBX0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006356">
        <property type="term" value="P:regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14132">
        <property type="entry name" value="STKc_CK2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000059">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000088">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="40"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU369118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY62617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="350" mass="40778" checksum="046D6C5B213BEE8E" modified="2018-09-12" version="1">MDSTEAPSISRVYADANTERGATWYDYDQLAISWGNQEQYEIVNRLGRGKYSEVFGGVDVCHGYRKICIKVLKPIKKKKVKRELKILMNLRGGPNCIELLDVVRDARSNTPALITEFVNNMDSKLLYPTFSDYDVRYYIYELLKALDYCHSHGIIHRDVKPLNILIDHQQKKLRLVDFGLAEFYIKGVELNVRVASRYYKGPELLVEFGYYDYSLDMWSVGCTFGSMIFRRDPLFHGHDNNDQLCKITRVLGTTDFWAYLDKYQIEIDANLDALIGTHSRKPWLKYLTSGPLELIPFQIENQRFISNEAIDLLDKLVRYDHQERLTAKEAMQHPYFAAVAQADQERQQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MC39</accession>
    <name>A0A2X0MC39_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C007g04794 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C007g04794</name>
        <name evidence="1" type="ORF">BQ5605_C007G04794</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY63367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MC39"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY63367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="60" mass="6526" checksum="366A30A0BB23C5C2" modified="2018-09-12" version="1">MSHKTSSHELRHATSLAFCATPLHLPKSRFGLSRVPPRLPTSRAVKDCQASCARTPESPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MCZ7</accession>
    <name>A0A2X0MCZ7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C004g02807 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C004g02807</name>
        <name evidence="2" type="ORF">BQ5605_C004G02807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY67778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MCZ7"/>
    <dbReference type="STRING" id="796604.A0A2X0MCZ7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037652">
        <property type="entry name" value="Mim2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19117">
        <property type="entry name" value="Mim2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY67778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="195" mass="21316" checksum="9B72CE829DD72E38" modified="2018-09-12" version="1">MAHPTSPTTGYLKLDADPSAIDTPTSSTSTVSSNAAASTSTSTNTRIEPTNSTVATAWPYNPTPYASTSHPTPTPHPFLSSSSSFSSSLASPSSEDEDDLSDLSSESSWTSSRIAYEDEQQWQASMRQLQLIWNVVALPFAAKWAGRKFFGRWQWFGSGDKRFWFGTALAKRVPETWWRTTTATATATATTTRAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MD12</accession>
    <name>A0A2X0MD12_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C009g05467 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C009g05467</name>
        <name evidence="1" type="ORF">BQ5605_C009G05467</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY81132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MD12"/>
    <dbReference type="STRING" id="796604.A0A2X0MD12"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY81132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="626" mass="69853" checksum="B66E05B966759B20" modified="2018-09-12" version="1">MSFGKPEVNLSGPFCALPAPDWDLAVHGRCGAVLQPAHRSTRIPNELPPLPPEARHPVMAMMDSSLLKRVEQTLAAFLDEHELSSAVLSKNVELLKQTPAALLCTRGPTCTAIIHDLRIRVLEPLLQFLLNQLELKSNPGASPSPHYRLQFRPQDPSQPDGVTLALMKDRPGTCVALMVIHFEEDDNFLSFGPQTNLFARKGECRYHLHHDRPIPLQNGGRSHGAQAILNKLALLMQSAVERHPETGEAIVPVRFGMILSTQLGIFAEAIVKPQNPKDFGLIYSPLFHTIGAIHYLDRETSFTLTRGSVALMFLASMIDHLAKTPEPPFEVVQRLFGQADPSNAKRWTFQRKPRRRMLKTGWTPPSSVEVFSVDDYRVEAKLSLAAFPPRISISNGRMPQARGGYEAVTFEVVETGPAQDNRFLSDLVDVEPQSLPHLVLPQFIAEGGFAVVRAGLLIGRSSVPDFDSDADTEMHTAEADRLGSSIWIPRTSIPTDQAVVLKSFWDLPSAVHEALFYEHVFPLLPSEARALLPTYHGAYRDPKGTDLGIILGCGGRPIHKKEVDEVLKKKVADAFRVFDKCGVEHMDRELRNVLVRNDGSLCIIDWNLARLNFDRRFLKYGTEFRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MEJ4</accession>
    <name>A0A2X0MEJ4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C005g03621 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C005g03621</name>
        <name evidence="7" type="ORF">BQ5605_C005G03621</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MEJ4"/>
    <dbReference type="STRING" id="796604.A0A2X0MEJ4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050911">
        <property type="entry name" value="DRAM/TMEM150_Autophagy_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324:SF2">
        <property type="entry name" value="EG:22E5.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324">
        <property type="entry name" value="FASTING-INDUCIBLE INTEGRAL MEMBRANE PROTEIN TM6P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY77384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="221" mass="24190" checksum="1CEC60001A1825BD" modified="2018-09-12" version="1">MSQVGSFHENLFIPGCTFTAVFYSATLLLERWLRHTHRIPGSSRPDIVRYGVFSCVFGFFGGSALLLISICDVYRHAAAHWASTLVFVLCMAASSICQTIQVRRLGSLLSQDADADHSKSDEGSHDGHGQGLKRSGRIKLVILVIALACTLSFAVLFGVCFTEPNTRAPSLRCNRVESASATFEWIVAFLFDLFLCTFILDLAPAVTRRVSFECSGTVDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MFK4</accession>
    <name>A0A2X0MFK4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C005g03669 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C005g03669</name>
        <name evidence="1" type="ORF">BQ5605_C005G03669</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MFK4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY77562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="38" mass="4430" checksum="5071D29CD3CEC282" modified="2018-09-12" version="1">MTHSAKRTPRAQVSYHLELVASLSFSFLLLEDTKRWPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MFY9</accession>
    <name>A0A2X0MFY9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C008g04980 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C008g04980</name>
        <name evidence="1" type="ORF">BQ5605_C008G04980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY78878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MFY9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY78878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="65" mass="7718" checksum="323377074B3FD42B" modified="2018-09-12" version="1">MHKLRSLDIAHHVTVRVWTSLCSQVVVSAGNPHRALTEVSYKKWFQLTLRDRDFRERLGRETAWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MGE9</accession>
    <name>A0A2X0MGE9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Lipoyl synthase, mitochondrial</fullName>
            <ecNumber evidence="9">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Lipoate synthase</fullName>
            <shortName evidence="9">LS</shortName>
            <shortName evidence="9">Lip-syn</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Lipoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C008g05150</name>
        <name evidence="12" type="ORF">BQ5605_C008G05150</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine + 4 H(+) = [[Fe-S] cluster scaffold protein] + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 5'-deoxyadenosine + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="9"/>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MGE9"/>
    <dbReference type="STRING" id="796604.A0A2X0MGE9"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000036">
        <property type="entry name" value="Lipoyl synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031691">
        <property type="entry name" value="LIAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004019">
        <property type="entry name" value="PRK05481.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009544">
        <property type="entry name" value="PRK12928.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="LIPOYL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949:SF0">
        <property type="entry name" value="LIPOYL SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16881">
        <property type="entry name" value="LIAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01058">
        <property type="entry name" value="lipoyl_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="11">
        <location>
            <begin position="119"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY79501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="392" mass="43222" checksum="22CEDED9398B73CE" modified="2018-09-12" version="1">MMATTRPLQRATAHSIRALATQSSSSPSPARPRLEALRADLLTVDDFLPDSTPSSSSSLSQNRVVFTKSKAQRLPSYLKTQVPVSASYNKIKNDLRGLKLHTVCEEARCPNIGQCWGGDKGDATATIMLMGDTCTRGCRFCAIKTAKLPPPLDVHEPENTAEAISRWGVGYIVMTSVDRDDIADGGASHFSETIRKTKAKAPHILIEALTGDFQGDKDAISLVARSGLDVYAHNMETTENRTPFVRDPRATFRQSLEVLRVAKEAKPGLITKTSIMLGVGETDEDVLETLKELRKVDVDVVTFGQYMRPTKKHMKVSSYVTPEQFDHWGREAERLGFLYWASGPLVRSSFKANELLKSVLGKRLIKGMKGRGQDVDVMGQDGERRTLEGVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MGN8</accession>
    <name>A0A2X0MGN8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA cytidine acetyltransferase</fullName>
            <ecNumber evidence="9">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">18S rRNA cytosine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">BQ5605_C009g05533</name>
        <name evidence="9" type="synonym">NAT10</name>
        <name evidence="15" type="ORF">BQ5605_C009G05533</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in 18S rRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51424"/>
            <dbReference type="Rhea" id="RHEA-COMP:13575"/>
            <dbReference type="Rhea" id="RHEA-COMP:13576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a cytidine in tRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in tRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53876"/>
            <dbReference type="Rhea" id="RHEA-COMP:13670"/>
            <dbReference type="Rhea" id="RHEA-COMP:13671"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with TAN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="9"/>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY81905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MGN8"/>
    <dbReference type="STRING" id="796604.A0A2X0MGN8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990883">
        <property type="term" value="F:18S rRNA cytidine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051392">
        <property type="term" value="F:tRNA cytidine N4-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904812">
        <property type="term" value="P:rRNA acetylation involved in maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051391">
        <property type="term" value="P:tRNA acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03211">
        <property type="entry name" value="RNA_acetyltr_Nat10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033688">
        <property type="entry name" value="NAT10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007807">
        <property type="entry name" value="TcmA/NAT10_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032672">
        <property type="entry name" value="TmcA/NAT10/Kre33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013562">
        <property type="entry name" value="TmcA/NAT10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027992">
        <property type="entry name" value="tRNA_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925">
        <property type="entry name" value="N-ACETYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925:SF5">
        <property type="entry name" value="RNA CYTIDINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13718">
        <property type="entry name" value="GNAT_acetyltr_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05127">
        <property type="entry name" value="NAT10_TcmA_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08351">
        <property type="entry name" value="TmcA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13725">
        <property type="entry name" value="tRNA_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TmcA/NAT10 N-terminal" evidence="12">
        <location>
            <begin position="19"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="TcmA/NAT10 helicase" evidence="11">
        <location>
            <begin position="312"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="13">
        <location>
            <begin position="569"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="domain" description="Possible tRNA binding" evidence="14">
        <location>
            <begin position="808"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="466"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1060"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="466"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="477"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1080"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1092"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="508"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="670"/>
            <end position="672"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="677"/>
            <end position="683"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="771"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SGY81905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1108" mass="122453" checksum="AE716C8B0A9DA952" modified="2018-09-12" version="1">MSGANATGRRKPLDTRIPTLIANSLQTSHRSFFLLLGDRAKAHAQIVNLHFLLGQSIAGLANPTDAQKKNPRPNVLWCYKKELGFTSNRKKREGKIKRDIKRNQRDVGEMDPFELFVSVTDVRYTYYKDTHKILGQTFSMLILQDFEAITPNLLARTIETVQGGGIVVCLLQGMKSLRGLYSMTMDVHSRYRSSTSTAAPVARFNERFLLSLGANPACLVVDDELNVLPISAGKDIVAIDPDFGVGVGRSAGKGKRKEAPGEAELQALKEGLSDTKGIGEIIAQARTLDQAKAILTFTDAITSKTLSQTVSLTAARGRGKSAALGLSISLAILHGYSNVFVTSPSPENLKTLFEFIFKGFDQLGWEEHLDYDIVQSTNPEWKGAVVRVNIFRQHRQTIQYIQPQDFHVLGQAELVVIDEAAAIPLPLVRSLLGPYLVFMASTINGYEGTGRSLSLKLLQQLREMSRPSSAMSAPSSTNGGNTDDKASGSTPLATVRTLKEIKLETPIRYGPDDSIEKWLNGLLCLDATISTSLKKTLQGCPHPSTCELFYVNRDTLFSFHPASELFLQRMMSLYVASHYKNSPNDLQLMSDAPGHHLFVLLPPLKEGDNTLPDPLVVMQVALEGNISKQSVLDNLSRGKMAGGDLIPWTISQQYQDDDFASMSGARIVRVAVHPDYAKMGYGSRALQALNSFYSGELLNLDEVVKEMDLETFEDVAKVDEDATLQTDQIAIRDASKMPPLLQRLSERQPENLDYLGVSYGLTPLLFKFWKRAGFSPLYIRQTQNDLTGEHSCVMLRGLNKNRQEVGRWLGAFSLDFRKRFIALLSYKFREFSTVSALSVLEAANQGIYASTTEEDEERRVGGDVLVGSEVKSFFSPFDLKRLDSYAQNMLDYHVILDLLPTLAGLYFSKRFPEDVQLSGLQASILLALGLQRKSVEDVEKETEHQVAVAQCLALFSKTIRKLTKSLQTLQKEDVAKLVPDASLGMDKKTQAFVNQASGASTAVVKGGVQGLEEELDQEGREVLKALKESQREVIDSLDLKQYSIAGTEDEWAQAQAQLAKGSGVISIKNPESTKGLKRKLGGEESKKEEGGKKHKKDKKHKEGKKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MGQ6</accession>
    <name>A0A2X0MGQ6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C008g05061 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C008g05061</name>
        <name evidence="3" type="ORF">BQ5605_C008G05061</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MGQ6"/>
    <dbReference type="STRING" id="796604.A0A2X0MGQ6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Right handed beta helix" evidence="2">
        <location>
            <begin position="347"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="596"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY79167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="655" mass="69632" checksum="36B38C8F93023F25" modified="2018-09-12" version="1">MSSSTMVTTTTERQRNRAGRRASRGVLKLTVALVATALLTAPLPCAEAFPTLRGVPARRSSILARPATRSVPGTPSRSLGPQFYQDEEDREIQSRIDTMAAAAMASHIAKKKARATESAEKIRMRALDEVVDLDAIFSGNVSNDTIIDGSEMDATTKVSRTPTCLGSWVTEVDINKLFYYGGANTTVTLCPRATINLTNTIFFTAAGQVLTTAVYGVTGNPTDDARARLVVTGAQQSCAIYGACDQCSNIVVSSIQVLGQRDVLGYLSNGLALLELGGMTNGQIVRNVKASEPRGWSVVHAIEGTNLVCSNMLIENNQIGPSGNAPNTGLQFRRRAVNATIAPGQWADGISLACKGSTVRNNVVTDATDGGIVIFGAPGSLITGNTIQSVTRRALGGINAVDYAPFAGNYSGTVVENNHLITNGQMMKVGVAIGGMIWGSDNRTASRGHFGTFRYNTFTSLNDGYFGYSIAVAGHENATVIGNNVFLGRFGGGPSPACIPDSTIPTPQALVRDSWTTPGSSLQAGFNDTPLVFLICSQPGVIQPLSASVDNLGAAFVRLVEKPETEAAEVDVLVEKRGGQIWRGTKGFAGVAQERPAKTVEATKTQPTRRSTLKKKREEVEKSQDEVPQAKVTPIVSRIGFENPFGLLERAKRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MGT1</accession>
    <name>A0A2X0MGT1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C009g05563 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C009g05563</name>
        <name evidence="7" type="ORF">BQ5605_C009G05563</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY82344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MGT1"/>
    <dbReference type="STRING" id="796604.A0A2X0MGT1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF83">
        <property type="entry name" value="ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="98"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY82344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="683" mass="73677" checksum="13306CD0084B4D3B" modified="2018-09-12" version="1">MLAPCYPSLYPDIGSEAVKGHGRIRRYLQTKEALTERPAPHINVVADILASSVKRFGDRPALGWRDLLRMHEEEKEVTKKVGNETVSETKKWSHFELSDYKYMSYNELASKVKAAASALVETGHSSKTIFNIYASTSVNWQVMANGCASQGITFATAYDSLGEDGLQHSLAEPEVYGLFTNANLVSTVASVISSGKTPSVKVVIYDGKDSDVKTGALDKLAKTGVKVYKFDDFIALGREKPHSPNHPQPEDLACIMYTSGSTGAPKGVLLTNANIIAAVGGAETLLHDLITPDARYIAFLPLAHIFEMAVEMTLLYVGIPIGYGTVKTLTDTSVRNCAGDIRTFKPTIMCGVPAVWELIRKGIMAKVKAGGGVKQKLFNYAVNAKMAAGPGTLTARIADAVVFKPVKQGTGGALKYIINGGAGVSKETQQFLSTALCDSMIQGYGMTETCALSFILPPSLLQSGVVGVPCPSIEAKLVDFEEAGYFSTNSPPQGEVWIRGPTVTKGYFQREDLTKEAITEDGWFQTGDIGQWNPDGTLSIIDRKKNLVKLQGGEYVALERLESIYKSTPCVANIAVHADSNATRPMAIIVLHEGNSKNLAEANGMDGSDLEALASNKDFKKLVVSELAAGAKRANLKPLEQISVVVLTAHEWTPQNGLLTAAQKLQRKAILEKYKDEVSAVYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MH43</accession>
    <name>A0A2X0MH43_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C016g08127 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C016g08127</name>
        <name evidence="2" type="ORF">BQ5605_C016G08127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY20694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MH43"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY20694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="109" mass="11775" checksum="4B04E0C68F77ACCA" modified="2018-09-12" version="1">MFDLPEDEEAYDFHYCGNTQSAEPVTAHSSREATAIQSAFLKFPTTDCTNTAPTPTPTHNDMSSLSGPERSSKMLLKVSASGVQLGLSLPPAVVGGFRHCDWVDSCPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHU1</accession>
    <name>A0A2X0MHU1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C031g10955 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C031g10955</name>
        <name evidence="2" type="ORF">BQ5605_C031G10955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000068">
        <property type="protein sequence ID" value="SGZ06596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHU1"/>
    <dbReference type="STRING" id="796604.A0A2X0MHU1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018814">
        <property type="entry name" value="DUF5427"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28265">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28265:SF1">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10310">
        <property type="entry name" value="DUF5427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="612"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="643"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ06596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="653" mass="68466" checksum="F98F5EDD2D7388E2" modified="2018-09-12" version="1">MSNLNSSTNRPTPSSRTGASSSGGGHARDDVLQFLESLDDYSNSKPTTSTTSSGSVRPSAPSVLASSANSRTATTHTLSNSTNARGATGAAGAPPPQGSLRSSQNNSSLGISTGTPGNATTAPSSANPASSSTANPATANSNATEAQSVLDFLDEITQRSSTPTHPVQARPLPAPRTTGGGTAPSSLSRSTSRTSIQSTASSAPPPRRSTDSVRSTRIPASNSSNALSTSPPTYQHNMSSPTTTHATAPSSNDSAAANNNAGGWGWSSMWSQASNVVQQASHVVAHARTVAEEQVLSATQQAKEGGLSSLPGGLIKALGENEQAKKVMGLASNVHFDQLGKDLKSSTLKSLTDLINAVAPPIAEHELLKVSLSHDMIGYDGVEQLVYSSLSKVSTRGSVQVIIELRTDALCRQVMEQVEGGTLIVNKGDQETQRHSESNDEERDLNLVEGLEAAWKLAEANLDQLIKTTFKPSPAPNANNSKTAEGGITVPVTTCPIYMRIQPCLAPIPFLPTSLTTISPTEGSATTSSAKALFFLLVLNDPTHGLKHVSLSQSLPANWLDIPFEENEWVEDLMVEVIRRSVEIIGQEYISHRMSARSLAIQKARDLAQAQLDQEHAQGGGEEPSIRVSFEGGDQQQQERSRQAAAAMAGLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIK7</accession>
    <name>A0A2X0MIK7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C039g11765 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C039g11765</name>
        <name evidence="2" type="ORF">BQ5605_C039G11765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000060">
        <property type="protein sequence ID" value="SGY89717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIK7"/>
    <dbReference type="STRING" id="796604.A0A2X0MIK7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF20">
        <property type="entry name" value="FLAVIN-CONTAINING AMINE OXIDASEDEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY89717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="573" mass="64576" checksum="EDCA35D2D6FDD513" modified="2018-09-12" version="1">MAPRRIAIIGAGSAGMSAAYALSLTSSKSKDKSGEGFEVVLFERSSACGGMATSSDIDETKYGASYINDGVQGASPVFYNTFKVFEELGFGSSEVGMQCSFGKGDDEFWSNVFPSSVIDKSVHRPDFSKGGCRGFQSDIKRFGKVLTIIKTFEPVFALISVERMLKLFRFSPDFGEVIVYPLVALFFGTGNQTPFISSAILERVFKDPSMRLFEYSSTSFLASIPEMRAFPRLSLLYETWQKVIEDNGNVEFKLSHEVTGMKRSSKGVEINYRQTQGTDNGQQVVDPGLEQEDKFDDVIICTDADATLKILGQGASWMERKVLGNVKYLWDITITHSDLDYMQKHYNVTYSDDLASTSRDDDKEAQEQFKFAKDHFRPLYYIRSYPSDKKKIEMSFDLTHYQPQFKGESPYGPDHTGIPPRHPTAQLPSKPSLDESAASSIRQEGQDDQGKPEPPLKKHVFQTIFLDKDRSRDLWSIGEIKEEDIVMKKWWKQQSHRWQHYGGTVPWMMFLNGKHHTYFAGAWTILNMHEIGIVSGFAAAYRLGAPYPFVEDGDAKRLFALYLGASHGCRMVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIP3</accession>
    <name>A0A2X0MIP3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C018g08742 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C018g08742</name>
        <name evidence="1" type="ORF">BQ5605_C018G08742</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY26521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIP3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY26521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="88" mass="9898" checksum="6E38E1E78779AC83" modified="2018-09-12" version="1">MIRFCNYRPLASRLPLRQPTADTQITQIQLSWSTDEPLECDTLPRPLDAWRDKFKDRGAITAARKQGYRSIAIAGHRLPFGVEGSGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJ71</accession>
    <name>A0A2X0MJ71_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C038g11654 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C038g11654</name>
        <name evidence="25" type="ORF">BQ5605_C038G11654</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000061">
        <property type="protein sequence ID" value="SGY91278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="515"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="1104"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="695"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="756"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1404"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1457"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="2041"/>
            <end position="2063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="1404"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="1457"/>
            <end position="1466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGY91278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2063" mass="225960" checksum="B8AB0666A023DD27" modified="2018-09-12" version="1">MDTSSPLTTGAHPTIPAEQLATLTSLLSGLTTATSATSSGTSCTAFPKHARLDGPKTFASWTRQLRLCLADDIRSYVLDGIVPADWTPLHRSARDVVARELLANSIDSADVSAVLDQIPTADLTAPKIYSTLKSRYALDDATCTLELFSRLWSFRPMPGTVGEFDGWIMEFKAIAQEIIDTKTTINDVLAIAHPSLESFKASFTDEQRTQRSLPAIDSLADRMRVQLRSTNVPSTQLALLASSSSRPTRPKCLACRSPSHRVAECPVRAKHPPPGPCRSCKQNHWSFDCKKALGNGKKADTANSIADSQHHVGCIATGLLARRRQLRTNSFVVDSGATSHMVSDKSLFTTYRHIAPTKIGGIAGGINAIGTGNIAFVAASGHPITLTGVLHTPGLFVNLLSVSRLCDTDDVRVAFTKHGIDITKDGNNIAEGTRLNKGLYLLDADHSKCQHLALLSRSQSSVPLLTLHRCLGHLAPSSIQKMVAAGLLEGLGAGYSDEEVEKFVCNACLSAKGHRLPFPDSDSHSSERLGLVHSNVLSLPERSLTGKRYLVTFLDDYLRKLWAYAIGHKSEVFSVFKTWLAKVELETGATLKVLRTDNGGEYCSRAFTEFCKARGTRRQYSIPRTPQQNGRAERVNCSIVEGILALLADAHLPKTFWEEAAAYFVYCKNLVQHSALDKATPNSVWQGGRTTASALHRTGRGLRRAERAGRPGPGLRHTERGWDLGARSEPGPLAQPRGSLAVDLARAALLFHSSRTRPSHHHIMDSSPASPLAPRDPSSPESSIGEQIATLQAQLAALQASQPAAAAATPAVTAVPGNAATASKVVFPKHARLDGPKSFTNWLRQLRLALPNQVRGYVLDGVIPPTWTADQLAARDDAAREIIVGSIDSADVSATLDAIPSDNLSAPRIFAALKARFAPDDATRTLELFARLWDFRKMPASVEAYDTWLREYMSIAQEIRDAKTSLNDVLATHVLAMVPSCLDSFRLTFTDEQRNRRDLPELTTLTDGQAIAHGTRVNDGLYLLDADHTKCQHLAFLSRSESPVPLLTLHRCLGHLAPSSIQKMIAAGLLDGFGAGYSDKDVEEFVCNACLGSKGHRLPFPDSESHSPERLGLVHSDVLSFPTPSLTGKRYLVTFLDDHSRKLWAYAIDHKSDVFPIFQTWLAEVELETNARLRILRTDNGGEYRSNAFTEFCKSKGIRRQYSIPYTPQQNGRAERVNLSIVEGVLALLADARLPATFWDEAAAYFVYCKNRCSHSALAKQTPEFVWNGQRTTATALHPFGCTAWLTVAPDLRSKLDPKAARVIFTGYDLASKAFRFFDHSINKIVLGRNATFLDNDFPGLPVTTPVDADDTDRQFVVPADTPAPAVKTRTPLVRSAHIDVSSSLDDSAMSAVDVAPGYTGGSLLNSTDTRSSSSPSLSPFSSPATSSARDPSLNDSDDPLDLLSSNTAVRLNLMDVHRSDDDTPETRAPAVDPVGQPSDDDSPDEIDFLSRHHRAFIATDDDDPTLDAIEPVKSITSDPQTWREAMSSDEHNIWVEAAAAEFTAMRDDFKVFTIEPRSSVPPGATIVTSKFVWKTKRNASGDVTGRKARLVAQGNRQRNGIDFSETFAPVARFSSIRCLLALAAANGYHVHQADIDKAYLHGELDHDIWMTTLRGFDFPSDKVLRLRRSIYGLKQAGRIWNRHIDTSLKNLGYKATGTDHCIYSRIDDRQRPHYIALYVDDLLIVSPHLDEIERVICGLEQRYGVKRLGPAEYILGIQIRRLDDGSIALSQERYIMDVLARFHFDTTTRGTTVPMTPGLSLTAIPGQGTERIRSWYLQAIGSLLYISLGTRPDIAFAVSYLSRFANNPGRRHWIAVKHVLRYLRATYRDELLYARGPAKVTGVVGYSDANWGACVDTSISTMGYVFYLAGAAVSWSSKRQTRVADSTTDAEYLALSHAGKEAIYLTQLLSELHVSPIAAAHIFTDNKAAAAVAHDPVRTSGTRHIRLREHFVRDMVNRGDISLSHVGTADMVADVFTKALGPKIFGTHCFALGLRTRHPRLKSTSRSRGGGVRNSLSARLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MK74</accession>
    <name>A0A2X0MK74_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sorting nexin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">BQ5605_C031g10904</name>
        <name evidence="15" type="ORF">BQ5605_C031G10904</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Prevacuolar compartment membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000068">
        <property type="protein sequence ID" value="SGZ05961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MK74"/>
    <dbReference type="STRING" id="796604.A0A2X0MK74"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034499">
        <property type="term" value="P:late endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051074">
        <property type="entry name" value="Sorting_Nexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963:SF2">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="14">
        <location>
            <begin position="121"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SGZ05961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="243" mass="26621" checksum="F92CF8059AB2EE98" modified="2018-09-12" version="1">MSGYTSGGTIAPSSGHSPFARANLPPSTSFSSFPSTSLSSPSGSSPYVTDRPSNSRFAYHEPTPATMSSSSSSQTSPTKNHNGVGGGGGDQAEAVNAPSSPSAGHEARGQTLEEMYSAPENTLEIEVRDPRTQEFGRKMFTDYEIMCRTNIPAFRVRYSSVRRRYSDFEAFRELLERESTRVSIPHLPGKVFSGRFSDEVIEQRREGLERFLQVVAGHPLLQTGSKVLCAFLQDPSWNKSDWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MK94</accession>
    <name>A0A2X0MK94_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">4a-hydroxytetrahydrobiopterin dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">4-alpha-hydroxy-tetrahydropterin dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C034g11348</name>
        <name evidence="6" type="ORF">BQ5605_C034G11348</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:11920"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="EC" id="4.2.1.96"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pterin-4-alpha-carbinolamine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.96" evidence="3"/>
    <dbReference type="EMBL" id="FQNC01000065">
        <property type="protein sequence ID" value="SGZ00438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MK94"/>
    <dbReference type="STRING" id="796604.A0A2X0MK94"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008124">
        <property type="term" value="F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00914">
        <property type="entry name" value="PCD_DCoH_subfamily_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.20">
        <property type="entry name" value="Transcriptional coactivator/pterin dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00434">
        <property type="entry name" value="Pterin_4_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001533">
        <property type="entry name" value="Pterin_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599">
        <property type="entry name" value="PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599:SF0">
        <property type="entry name" value="PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01329">
        <property type="entry name" value="Pterin_4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55248">
        <property type="entry name" value="PCD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGZ00438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="133" mass="14622" checksum="6C1E5E08DF6FB49D" modified="2018-09-12" version="1">MGWSLARSTIRRGCDSLGLRMASSSAPTLRNTPASSTDLAPLLEQGWSLTAPASSSQNKLKKEFIFKDFSQAFSFMTRTALSAEKLNHHPEWFNVYNKVIIELTTHDRGSSLTGLDVRLATRIGQFAQETGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-05-29" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLJ4</accession>
    <name>A0A2X0MLJ4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C023g09743 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C023g09743</name>
        <name evidence="4" type="ORF">BQ5605_C023G09743</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPA3 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ24742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MLJ4"/>
    <dbReference type="STRING" id="796604.A0A2X0MLJ4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019216">
        <property type="term" value="P:regulation of lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010754">
        <property type="entry name" value="OPA3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499:SF0">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07047">
        <property type="entry name" value="OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="100"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ24742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="164" mass="18964" checksum="1982C4787200F1CD" modified="2018-09-12" version="1">MASVKIASLFLRTLSKPIANRLKNQAKEHERFREMTISFAQFLHRSEMRMRVSLLGETHPVVVRPLNDARAIDAGANFISETFLFAFAASIILAENWRSRRAEGKRRDQVQDQLEAHEERLAQLSLDLEKERKERNEGLLREEKLENIVEQVSRWSTLSFGGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLU8</accession>
    <name>A0A2X0MLU8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">BQ5605_C029g10662 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">BQ5605_C029g10662</name>
        <name evidence="18" type="ORF">BQ5605_C029G10662</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ15323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045358">
        <property type="entry name" value="Ty3_capsid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19259">
        <property type="entry name" value="Ty3_capsid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="17">
        <location>
            <begin position="636"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="893"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1508"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="893"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="933"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1508"/>
            <end position="1531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1538"/>
            <end position="1551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="SGZ15323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1600" mass="177704" checksum="A80FF91AA96C460A" modified="2018-09-12" version="1">MGLVQSMLLDSGLPMRFCSDALAVVTFVLNRRPHPRIQGKTAIKVLLGKKPSLAHLQPFGSTAFVHVPKERRSKLAPRFIQGVFIGYSGGYNYRVWVQSSKQVYVSHHVTFLETPSVVTLSQDFVPQEPLDGEAEVALAPREGYAIVRTGPNPGQFENVDPSNILPAGSRRQPQPPENILPIISAIMVDVLDTPPMFHNKLSYDAYCAAVFAEEDIEIPKTFEEAMKSPYRNHWSAAMVSELLQFDHHGVFQEVKWHEGIRVLGTIWVYSIKRDANGKIIRFKARLVAQGFAQRPGIDYHDTYASVACSLTILFLIALAAAQGLYLEQFDFDCAFLNGKMTEDVYCLKLVGSMYGTKQAPREWYRAVNDLMVSRGYMRATADACLYIKHSGTSFAIITLYVDDGLIASNNQSFLDSELGSLHKAFQLKHLGPVSYFLGFEIHRTKDYILVHQSKYVRTMLEKFDFASPSKRRAVTPMDDRPSLRIDATPFADVSLYQSAFTTRLMVYSDASFADDPESRRSVGAYASMLAGGVISWQSKQQSMIATSTTKAEILSASSATREAIWLRRLAGDVGIPQAQPTIIQEDNAACIQIAKDPVDHMRTKHFDIAHLFVRERVASGEVKLEYCPTHVNAADIMTKPLGFQRFDQLCALLGMVSLVSLTGGSVRSGYLVTFVDDFSRKTWVYPIGHKSEVLPTFKDWLMEIKNETGRRVKTLRSDNGGEYVSTAFNGFCVARGIRRELTIPYTPEQNGRAERLNQSIVEGTLALLIDSGLPRTCWDEAAMCYTHTKNLLPHAALKGGVPNCCWSGAPPTVGALRAFGCRAWATVPAHRWDKLDPKGIPLVFVGYDRHAKAWRLLDPSSMRVSLSRNVTFLETEFPFVAVPARITPPSVPGFYPRPPPADAPATPLPPVLVEPTQPPSLDDDATSSIHLPQRPPEPAPPEPTPLAKVKPTWEYGDVAKVGPDPGKYGEIDAQNIIAGPRTCRQLVPTLITREDLVGGPDGPTPAFQGMLRAFASTKAGFAEHNLSVVRDPANWGDVIRSGQQDAWGGPAHNESDSLLNKYEVFEVIDSCELPAGEILLRLGWARLVAHGCAQRPGIDLKQNYAPVVKFTSIRALIALAAANGYHVHQADVNKVYLNGKLDKPLYMRVPQGIDMPGKILRLSKSIYGLRQAGTIVTNQQSEYSYKNNYINPASRPVILAIACCLRLSNLNPDSRSRFPIDLVDLTQASLDSLIDHDQLRTLQARNQALEAECRSHLSDKENYQITVTALANQQQTLSDFAKAVVNQQKESIDVIKSGLANLNVTAPANTTITPVKSQLAKPDKYDGKEKVKFKTFITQIKFYIFGNPSSFPTDESKIALIISHLTGDAFQHFEHAINAKDDSKPEWLTSYQKFLDQAELVLGDPVYRNNITRQLMSLVQSGPASVYASKFTQISSQLDWNQAALIAHFHKGLKLDLQAQLALHDDPQDLQSLIELAIKVDNKLHLARHRTNASTQFRQTNWQYSHSVNSPLRTSPVSQLQANPSTTNTSGPAAMDLDATRSRRGPLSEEEKLRRRTNRLCMWCASDQHLCAQCPTAPPMIPRHTALNALLWIWTWSTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MM99</accession>
    <name>A0A2X0MM99_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g01937 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C003g01937</name>
        <name evidence="1" type="ORF">BQ5605_C003G01937</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY37996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MM99"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY37996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="109" mass="12338" checksum="1896E994D437A42D" modified="2018-09-12" version="1">MRLAQSDLRLFIWDVEYKLTLVPKGYPDWKRVTAPTLETHTPFADETSPALDPTRLPTIGRRLVHPDEGSIHAMGTLVYRKTLDPVAIHYKIGKKTIILPSAHKPRPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MMC6</accession>
    <name>A0A2X0MMC6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">BQ5605_C025g10026 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BQ5605_C025g10026</name>
        <name evidence="16" type="ORF">BQ5605_C025G10026</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000087">
        <property type="protein sequence ID" value="SGZ27014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MMC6"/>
    <dbReference type="STRING" id="796604.A0A2X0MMC6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19510">
        <property type="entry name" value="RecA-like_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000768">
        <property type="entry name" value="Probable mitochondrial chaperone bcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="BCS1 N-terminal" evidence="15">
        <location>
            <begin position="78"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="324"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SGZ27014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="558" mass="61443" checksum="303EA2E84A2A8D9B" modified="2018-09-12" version="1">MSSSPTSSGKLPFELESILTSSATSPSHAVPSTPSSSNGTVSTASGGMDSIAASSANKGWIASMLDSNPIFSAGFGLMAVGVGLTFLRRSAVQIGTLAQRRLLVSLEISSKDASYLWFLQWMSQQAAKQASLSQKPLRRIGWDLDGLASRLKSHELAVETKYEQRGDGSSSAEFSLVPGPGTHYFRYHKAWFQVSESIKLRYVGSCPELILMHSSQVKRERATNMLDLNSGTPWETVTLTTLSRDRQLFSSLLTEARSLAQSAQMGRTVIYTAWGTEWRPFGRPRMRRALESVVLDKGVKEGIVGDVEAFMKRGSWYFQRGIPYRRGYLLHGPPGSGKSSFIQALAGSLEYNICVLNLSERGLTDDKLNHLLANAPERSLVLLEDIDAAFSSPTATSMTGEANARTRSTEQGFNANVTFSGLLNALDGVASSTSQRILFLTTNHIDRLDPALIRPGRVDLKIYVSDATSWQVGKLYQRFYSKSSEDSEGVEEGTLSEWKEELMKKVERDVENGTRVSMAAVQGHFIRNGAREALDGWERLVEEVKEDKEVRLRFASSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNA6</accession>
    <name>A0A2X0MNA6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C027g10371 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C027g10371</name>
        <name evidence="2" type="ORF">BQ5605_C027G10371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MNA6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015852032" evidence="1">
        <location>
            <begin position="20"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ28553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="52" mass="5694" checksum="CB319361967AF356" modified="2018-09-12" version="1">MTTAIQMVYLFIACKSVVSEAFAETTDRVALGPLVRTPDPALDRTSCTLEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MND0</accession>
    <name>A0A2X0MND0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="4">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C022g09490</name>
        <name evidence="14" type="ORF">BQ5605_C022G09490</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="4"/>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MND0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01795">
        <property type="entry name" value="Ubl_USP48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2230.10">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044743">
        <property type="entry name" value="Ubl_USP48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF722">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51283">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="12">
        <location>
            <begin position="240"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="DUSP" evidence="13">
        <location>
            <begin position="1024"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="11">
        <location>
            <begin position="1236"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="74"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="560"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="755"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="568"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="599"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="763"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="802"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGZ22455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1457" mass="161933" checksum="1BF303DE6DB0BB6F" modified="2018-09-12" version="1">MVKSSSHKTQVRPTPLQQVWHRVQEDNARALTVKEDRATGRMSTWSLSGSSKQDLDERLMRLAYGIEMASRAGQVTDDERGYPRSCTSRSSHDAITTNGQVGVQRDSPLVHTEQSRSSGAAQTVKEGTIVIDTTTDDDQDQSRAVGVQKPASRKGKEKATAKDPLECSSENCSTDPKCLNWLGQQKWEDTEKALETFASSRGVGEDPSQNLRDPGVPVGLKVGSTFAPDSWNILSRATCNLPQNLGATCYANSFLQVWFRDPVFRNGIYACKPVSPTCPTPITNSPLYHLQVLFTFLQTSVQAVYDPTPLIRSLKLDTGEQQDATEFQKLFMSLLDHEVSQAGKARGGSEGEEVAGLIASRFEGKIFYGTRCTGCNNASERSSTFNELEVTLKANCELEARVAESLGDERMEKENQYYCDNCQRKCDAIRYTRLHSLPPVLHFSLLRFGYSLKQGQRKKSQHTISYPPSIDMSQFVEASQREGDMWYDLKGVLLHKGVSAHHGHYVAQVFDDRYVFFLGGGAWVSLAGRSRSSPDARFCFDSSNQWYLFDDEVVTPIEDFDTSRVYKDEEEDGEEEDDEDVDEIVVSSDDEYQEGGSKGRGRPMSKVQGRGKAKAKAKAKVKGKVQVQNGDEKTDGTSKRPKSKDAYMLVYKRRSESAPQCQYRVVGTSEMAPAPNNVEPIPPLLALAEVQRLDDAHGKIVDEYHARVASVKEEFDRLREAKRSVYRVWQVVEEREGGGPSYAVDKRELVRWLGQGLKKKSRKQDSKGSGGDERDGGTEEMEEEVKEVKKVIANGVDGGNEPHSSITEVQSSGEGGQAMEYVEAGPMEGVADVKVDSSSNKLSSTAIMCEHGKIDPHKADLMKRVSKAGIEALSSLGVTLDPELQIPRDFCRDCVWSHVVEELYVLEHAEHTQAMNGADTGRDVAISKPWFKDWLRTPKPKMHVPGSASDPSPQGEPYLSDVKCEHGLTRHDPKRVEQLSFEESAILQSLFPDWQPMRLEQSQACPQCAKAEAKESKENDRMVALAKKEKSVLKSFTNDTRLGGTQILLTGTGEHFLVPYAFKKQWFEWNHSVSHRSVTSERPGELDNSQLLCEHQRLLADLKAENKKLRTIHPVTSQEWKLLQENYNAGPQIKVWQDYQTLQFLSSPASCEECLKRQRENFATTTIKVVTIGEDKFDKDGNYRKARVDSSDSDEITVLSSPPPATNGKRMPLKAQKTYGQKPVVVRFPPVGATRTSARVRNQGMLYENRSATFIEVNKTDTVKVLKISIDHKLSIPTICQRLFFKGEELDDSSATVEKLGILPDMVLELFEVKEGALGLSKLEDVGDEIRSTGKARREEGFGGTGLSGWEHVGGAENMVVDEANAVEEVPTGIEASRKRKIEDAVGSSSSASSAAEVAVPIASRKKGRQVIIETVKEEEEKAETMLMSEEGVTCPQCTFHNASGMTQCEMCDLPFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNH3</accession>
    <name>A0A2X0MNH3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C020g09087 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C020g09087</name>
        <name evidence="6" type="ORF">BQ5605_C020G09087</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000082">
        <property type="protein sequence ID" value="SGZ17015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MNH3"/>
    <dbReference type="STRING" id="796604.A0A2X0MNH3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000003">
        <property type="entry name" value="Calmodulin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF48">
        <property type="entry name" value="CENTRIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="48"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="134"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="170"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGZ17015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="224" mass="25059" checksum="015974B549DB3437" modified="2018-09-12" version="1">MSFPSSSSKAHSRPIASSSNANASPLLSRQKHSVASTSTSTPFRLSSDQLSEIREAFELFDHDRDQQLDYHEFKVCLRALGFDLKKAEVVRLLKEANGVNHANVAGGVGVNVGEMRIGYERFTNIVEGMIQRRDPMLELKRAFRLFDEEGTGKISLDNLRKVASDLGEQLGDEELRAMIDEFDLDQDGMINEAEFLRFVDALVWAIRSPAELTLTAVSWPTIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNK4</accession>
    <name>A0A2X0MNK4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C027g10438 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C027g10438</name>
        <name evidence="2" type="ORF">BQ5605_C027G10438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MNK4"/>
    <dbReference type="STRING" id="796604.A0A2X0MNK4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016034676" evidence="1">
        <location>
            <begin position="28"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ28753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="549" mass="56423" checksum="58FA1ACBACCEE144" modified="2018-09-12" version="1">MHVGASSNAAWLSLFAATISFISAIDAAPLTKGDTDITKTNGVKAKDDAACTAIGQFPTAIDGACVSCSSQFPGASACTVTAATRCSTGSLSAGACVTVCAISTFSFNGICTACTSKYQRAAACTTTGATKCNSGFLIGGQCARVCPTGFVNAASTRTCMPCTKFDTLAATCSAGKITTCVPGAYLNAAKNDCIACNTVNKFASACSSSTIVTACTAPYTVSTDKKSCVLGTAWSVYLLSSIPDTPYQANTRSPGSCGNRAVGKGAQVAVFDSDSSTCYASTSNTSVSTMANLVWDIDSTTIVYGTCKKNNALNPFAKARCRDVILTTSSCNLVFDRSLCSTLFTPCAGDQFRNYNGICQDCDDVYDDSLTCDIFNGATSCVAGDYLTNGTCSSCSDFDPNAASCSADGTVDGCNDGWVVSGNSCVVDGSDVAQVGLDTAWSYYPDSSIHNLASLTVLNTNSPDQYDCAESVYDSNFTMAVFDPTSHSCYAANATTALTKSITDVDGASVFVIEVCAANQAQVPTEQGSTCYDIKLDSASCQVNGGSCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNL3</accession>
    <name>A0A2X0MNL3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C055g12638 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C055g12638</name>
        <name evidence="2" type="ORF">BQ5605_C055G12638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000092">
        <property type="protein sequence ID" value="SGZ29165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MNL3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="382"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ29165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1152" mass="129484" checksum="6F99CF9E3174D8B5" modified="2018-09-12" version="1">MMNMAITDRAWTPVSHWQTLLSKIAFNPLDTIRQLHPITPAFTRPHYLGRGDKREICSWSRIDYILVQCSWANRLLSASTLFDAPCSDHRPVVATFALPTSNADAEPPLSLPSTSDFISRLNPTVFDDQDFVASIPGVVDEVYRRLEGTAPLGDVYDAALRAVAVAGHARYRSTRADMRRLRAESQSVMEALEARGEHMNEAERDAYAFAKSRLDQLAVKEAQWLRIRAHVPSVDSREGQSASIRTRLNRRSRQTSIVSLEDVDGTETVDMQQALGIASRHAQSLFTPDPARGDPTNARRSLLGPIRAAKCYDDDRSDPTFGRRLPLQARVALDEPFNFSEVEAALKKTDSGRSPGPSGIPYELFKALPTYFAPKLLDLFNSIWEGGKMTASLAEGLVRLLPKNKPGANLKSLGAYRPITLRETTYKVLSKVLVARLNGVLGELLPPAQHGFMPSRRSADAGSHLTLLLEKLRSLGTDVFPEGALLSLDQQSAYDRVDHAWIFNLFEAFGFGERFISLLRALYDPETLGVRYLINGFPTELVRLLCGLGQGDPLSCPVWNITFQPFLDALVRRGIALDLQKVWPGGPRAQLTHLAFADDAVVVVESPAALSKLETLSQTWYKATNGKTNTDKTLVLPLGPNWLRDETAQALPSVQEGESFKWCGYAFFRHGDSKLFWTHVLDRIKAKTRAARDRTLSPSGKVFYANAHIISTGLHVLSFDIPPQWFIKAAETALTDFVWGGAGRNTVARDFVFQAREDGGLGLISIGDIVHSVALRFWDAVAGSNEAIWAPLARESWRSLVAATRDFSPWGFFSSTARVEKLYRDSTRWGAVVAAARVTVPTIKSELLTLPELLSLPPRLPSLYAEGAKHAYDDADTVAKFAQIAELYWRDEGKGWALVGHRRGFWQHSKEPALQHEHVWSRVEAPRPRCFNFFGLTRPFTIRKLRRLVNVVRFPGREDRVKRFRDGTSQSDRKRFWRWLHDRFASAVEQDTHWRLMYDVTPTRKRQHTQGHASSPTCLFCGNDAAVIETVSHYFFECAYSTSFWGGVLRILFDKLGIEDTDVDPSTFTPEQLTMGLPLLRGRGRTTSKWMWVRLACAIGFQRLHLLRWHVHQRFEKDRVVAPPSIPSALRAFNRDYLSRAGFVPGARDWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MP27</accession>
    <name>A0A2X0MP27_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C050g12482 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C050g12482</name>
        <name evidence="3" type="ORF">BQ5605_C050G12482</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000097">
        <property type="protein sequence ID" value="SGZ29701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MP27"/>
    <dbReference type="STRING" id="796604.A0A2X0MP27"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="2">
        <location>
            <begin position="301"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ29701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="470" mass="52865" checksum="3462D554A6E74DC4" modified="2018-09-12" version="1">MTTIQPILALRHVYEPAPHVSIRDDLGPQTAVCTHCKAQHWELGATVFCVFGRLYHRLGALIPAVNQCPAFAQTWLINPAEATDTRLQGPDSAKTRIQRSTLTKLESMLRTGNRFMREFASAKARAGWDTAKEWILRLCLPPGRDRRTHNLPTSSTEMAMLICDSDTNTGDRGPQDLILQVHGDRCPDVRPKHQIVSSLHPSAMPLRYPLLFPAGEDGFHPNIPLCGFNQAGPPIARNREQIDNGVQLRELLDGLGPDEEDEQEDDEDEGDEEDEENGDGERRRSNKRGRGGSTRVSRSQYFAYHLHERDDYFSIPHVTQRLFLEFVIDGYSQVETDRLNYIRLHQESLRLTTAQGITDAVANGLTPDQIGRSVILGSTFKNSPREITQRYQDAMACVVKYGKPSLFITVTCNPEWPEIKAALGPNDKACNRPDLIARVFEAKSGNKRHAGCFGDECKMNRFCFFAVLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQ02</accession>
    <name>A0A2X0MQ02_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C023g09661 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C023g09661</name>
        <name evidence="2" type="ORF">BQ5605_C023G09661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ23922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQ02"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ23922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="118" mass="13271" checksum="ECC4D70FEE5E9000" modified="2018-09-12" version="1">MNRKGEKRRPSQAAWSKPRETLRAFTSETTSELDVLGLNRDTLGVDSGQVGVLEQGDEVRLGGLLQRTDRRRLEAKIGFEVLRDLTHKTLERQLADQELGRLLVTTDLTKSDRSGLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MRE2</accession>
    <name>A0A2X0MRE2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C073g12897 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C073g12897</name>
        <name evidence="3" type="ORF">BQ5605_C073G12897</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000122">
        <property type="protein sequence ID" value="SGZ34234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MRE2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="201"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="798"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ34234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1007" mass="113029" checksum="C735084CA5CC4282" modified="2018-09-12" version="1">MMNVFYKKKQLEARGEHMNEAERDAYALAKSQLDQLAVKEAQWLRIRAHVPSVDSREGQSASIRTRLNRRSRQTSIVSLEDVDGTETVDMQEALGIASRHAQSLFTPDPARGNPTNPRRSLLDPIRAAKCYDDDRSDPTFGRRLPRQARVALDEPFTLLEVEAALKKTDSGQSPGPSGIPYELFKALPTYFAPKLLDLFNSIWEGGKMTASLAEGLVRLLPKNKPGANLKSLGAYRPITLRETTYKVLSKVLVARLNGVLGELLPPAQHGFMPSRRSADAGSHLTLLLEKLKSLGTEVFPEGALLSLDQQSAYDRVDHAWIFDVFEAFGFGERFISLLRALYDPETLGVRYLINGFPTELVRLLCGLGQGDPLSCPVWNITFQPFLDALVRRGIALDLQKVWPGGPRAQLTHLAFADDAVVVVESPAALSKLETLSQTWYEATNGKTNTDKTLVLPLGPNWLRDETAQALPTVQEGESFKWCGYAFFRHGDSKLFWTHVLDRIKAKARAARDRTLSPSGRVFYANAHITSTVLHVLSFDIPPQWFIQAAETALTDLVWGGPRRNTVARDFVFQAREDGGLGLISIGDIVHSVALRFWDAVAGSDEAIWAPLARESWRSLVAATRDFSPWGFFSSTARVEKLYRDSARWGAVVAAARVTLPTIKSELLTLPELLSLPPRLPSLYAEGAKHAYDDADAVAKFVQIADLYWRDEGKGWALVGHRRGFWQHSKEPALRHEHVWARVGQKLKAKALLPKTAVRPARIPLKEDPHPRCFNFFGLTRPFTIRKLRRLVNTVQFPGKDGQDRALPGGQPQEPRVKRFPEGTSQSGRQRFWSWLHDRFASAAEQDTHWRLMYDVTPTRKKQHVQGHASSPSCLFCGNDAAAIETVSHYFFGCAYSASYWSGVLRILFDKLGIEDTDVDPSTFTQEQLTMGLPLLRGRGRTTSKWMWVRLACAIGFQRLHLLRWHVHQRFEKDRVVAPPSIPSALRAFNRDYLSRAGFVPGARDWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MRH9</accession>
    <name>A0A2X0MRH9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C018g08634 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C018g08634</name>
        <name evidence="5" type="ORF">BQ5605_C018G08634</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY25527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MRH9"/>
    <dbReference type="STRING" id="796604.A0A2X0MRH9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012890">
        <property type="entry name" value="GCFC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028211">
        <property type="entry name" value="Ntr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12214">
        <property type="entry name" value="GC-RICH SEQUENCE DNA-BINDING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12214:SF0">
        <property type="entry name" value="LD29489P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15458">
        <property type="entry name" value="NTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="271"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="512"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="702"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="324"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="372"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="521"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="536"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="708"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY25527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="952" mass="105839" checksum="61BC01EEA8C9BA92" modified="2018-09-12" version="1">MDPDEPLSAPIIKRRNLKGVRPSSSSSSLRSWGAHVSDPPRPEQADSDTTSAPGTPRTGSTNGVGTSTLEDGQEDAVVFRRTKNKKTPRAAVLAASTKPRPIKSSLSIGLSLPDEDEADSFVLTKRTSLPARKLLSVPDHHTTTQAILPPTSTLSPQKSSLSSVYSSEYLQELKSATLSTPPPPPPPPPPPPITTTSTTSHDDLTLSKFASRFATLDDRQSTSILTSPTRALDLTFNNSFLLTATAQPESSPIPTTAAIASAKARRERIRTQGPPNDFISLEIAPSKSGSQSRLVREDDDLGDDGMDRRADFESSLPLGKKATMVKRREEKEGMMRLIDEAEEEMEEEDDEEVREWEERQLARVNERRAAEEQTSAQPTYVPTPIPQTSTLPTLSNVQARLSAGLNTLESSRTLDVAALNHFEKERNELDTQEGELRSEATRIEEKNRWFNDFKNFIEDVAAFLDEKFPALEKIEKENLAIQKERYEIVSRRRFEDDSDNVALFTGASVPSVFSLDPQASPEDDEDKDGEEEEVDEMGRSTRRTEDRFGPRSGARVARLSARERRLESRKALYQPNGIVSTAEEDSAMWTDDDLISADSADLADALTSLQDLRKALFEDVRVDDFRDPNLGIRKKFEEWRSTYREDYENAYGGLALVGVWEFWARVEMALWNPFGIDQLARTPSGLDSYHWHSSLTAFGHASHPNGGADDDSHMDEDDAPPDESAEVVNALVTSVVIPRLIALAKASYDPWSKKQTMKALALVDEVSYCVETTSPKFEVRIATFLWGSGKNQRILTPPDISIAQSLVQAFLTRLQLGIIQASTLILPHLNQLSLPSNAFDPSTFLARERFLLRQLKLLQNAHKWRRYARNYRLPLSTVPSTPTTTPHQFTEIGSGASFDELLQRDLVAKVMLPVIEASWSTGGEKIAGKVLMVFQEADWIPALRRRLEGGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MSD4</accession>
    <name>A0A2X0MSD4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C115g13245 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C115g13245</name>
        <name evidence="2" type="ORF">BQ5605_C115G13245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000101">
        <property type="protein sequence ID" value="SGZ30090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MSD4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="450"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ30090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1243" mass="140236" checksum="572FE4617849566F" modified="2018-09-12" version="1">MMNVFYKKKTQKNTKKKKGWVFDGRILRSVFRLEELDVEIINMYAPVQEDDRRDFFGLLHFNAPRPKTLRILAGDLNDCPDVSVDRVSITDRAWTPVSHWQTLLSKIAFNALDTVRHVHSCTPAFTRPHYRGRGEERKICSWSRIDYILVQCSWANRLLSASTLFDAPCSDHRPVVATFALPTDFISRLNPTVFDDQDFVASIPGVVDEVYRRLEGTAPLGDVYDAALRAVAVAGHARYRSTRADMRRLRAESQSVMEALEARGEHMNEAERDAYAFAKSRLDQLAVKEAQWLRIRAHVPSVDSREGQSASIRTRLNRRSRQTSIVSLEDVDGTETVDMQEALGIASRHAQSLFTPDPARGDPTNARRSLLDPIRAAKCYDDDRSDPTFGRRLPRQARVALDEPFTLLEVEAALKKTDSGRSPGPSGIPYELFKALPTYFAPKLLDLFNSIWEGGKMTASLAEGLVRLLPKNKPGANLKSLGAYRPITLRETTYKVLSKVLVARLNGVLGELLPPAQHGFMPSRRSADAGSHLTLLLEKLKSLGTEVFPEGALLSLDQQSAYDRVDHAWIFDVFEAFGFGERFISLLRALYDPETLGVRYLINGFPTELVRLLCGLGQGDPLSCPVWNITFQPFLDALVRRGIALDLQKVWPGGPRAQLTHLAFADDAVVVVESPAALSKLETLSQTWYEATNGKTNTDKTLVLPLGPNWLRDETAQALPTVQEGESFKWCGYAFFRHGDSKLFWTHVLDRIKAKTRAAGDRTLSPSGKVFYANAHIISTVLHVLSFDIPPQWFIKAAETALTDFVWGGAGRNTVARDFVFQAREDGGLGLISIGDIVHSVALRFWDAVAGSNEAIWAPLARESWRSLVAATRDFSPWGFFSSTARVEKLYRDSTRWGAVVAAARVTVPTIKSELLTLPELLSLPPRLPSLYAEGAKHAYDDADAVAKFAQIADLYWRDEGKGWALVGHRRGFWQHSKEPALQHEHVWSRVGQLLKAKALLPKTALRPARIPLKEAPRPRCFNFFGLTRPFTIRKLRRLVNVVRFPGREDRVKRFRDGTSQSDRKRFWRWLHDRFASAVEQDTHWRLMYDVTPTRKRQHTQGHASSPTCLFCGNDAAVIETVSHYFFECAYSTSFWGGVLRILFDKLGIEDTDVDPSTFTPEQLTMGLPLLRGRGRTTSRWMWVRLACAIGFQRLHLLRWRVHQRFELDKVVAPPSLPSALRAFERDFLSRAGFVPGARDWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MSF7</accession>
    <name>A0A2X0MSF7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C049g12423 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C049g12423</name>
        <name evidence="3" type="ORF">BQ5605_C049G12423</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000111">
        <property type="protein sequence ID" value="SGZ30647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MSF7"/>
    <dbReference type="STRING" id="796604.A0A2X0MSF7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053244">
        <property type="entry name" value="HDAC_HD_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47558">
        <property type="entry name" value="HISTONE DEACETYLASE HOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47558:SF1">
        <property type="entry name" value="HISTONE DEACETYLASE HOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="2">
        <location>
            <begin position="395"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="823"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="926"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="848"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="933"/>
            <end position="949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ30647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="976" mass="102624" checksum="C103A7784C5493A8" modified="2018-09-12" version="1">MDSPSPASTYYSTVDTPSSSGTADSPPAGDAEAVQGGALDDSAALVNQLESMSLRASSQSPLPQQPPGAFPTVLHFGPTHAPATASLTVGEDVAAVKVESAGLPPSLQAAESPIRVTAAVAGPEYSSPSKILDVLSISSNASSLSSPGSNPMTPSPFPKIATDPHLTKPIVSPAPPSRRTVVIFQEACAGHRFIRSSDVTGIVERPERIRAVKTGVAAAWARLEARNVAQGGVRWMGNPPATPDSDDVAQNLGDLLNNMNIQDLKGKGKEILGGPFDVLQSTSRAAIDDPAIHLIHPLPHTAPDAPDADIAPPPPTSPPAASTPTRVSRASVASTPTRSGKDEAYPASTSTPTAAERGPATLPPWPQQLANLCRGASTAIATGPRHSEIPAHLPQGDLYLSEQSEDAIFGAIGAVCEGVDRVVQGARTTGNGYDRAFVAIRPPGHHCCEATPMGFCFLNNVAVAAAHAHLNHGIERVVILDIDLHHGNGTQDIAWRINADANRAVQELQAKSPRKGSPRKRGMPSCRPNLQIMYASLHDIFSYPCEDGDPSMVQAASLNLAGGHSQWISNVHLEPFGTEAEFHEKLYPKYRHGLLGAATKFLEQTASRDGEDENRTLIIISAGEFSPAHTSEPKLLTPFYGGTGMDASEHESAGMSRHRRNVPTTFFHRFARETVGLATTHAAGKVLVVLEGGYSDRALCSATMALMVGLTESPRLLEKTFLAQDGNEISWWEEKNLAKIEKACKPKRGKLHTPFAAGTAVLAANASGASTNGATATAATVDHPDAWLNRTVEIFAAIEGSETVAAPNSDAVAAVKDKAGLGSRTMQLRERRPRGLGQDLGFGDGSRDSSPQPSAQSTPDKRSGVGATQPFVTASTARGNDFISGEKAFTGLVATQDISSLKGRSQGSLEASHDSDTDSQFVMRHGHTSERTAPASDRSADDSAIALSAVTPEHHENAHPTVAPRIKFTWKQGGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MTQ1</accession>
    <name>A0A2X0MTQ1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C029g10627 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">BQ5605_C045g12224 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C045g12224</name>
        <name evidence="4" type="synonym">BQ5605_C029g10627</name>
        <name evidence="4" type="ORF">BQ5605_C029G10627</name>
        <name evidence="5" type="ORF">BQ5605_C045G12224</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ14895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000115">
        <property type="protein sequence ID" value="SGZ31655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MTQ1"/>
    <dbReference type="STRING" id="796604.A0A2X0MTQ1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040213">
        <property type="entry name" value="GIR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12292">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="3">
        <location>
            <begin position="10"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="172"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="120"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ14895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGZ31655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="259" mass="29415" checksum="A2B6E3255271A3BD" modified="2018-09-12" version="1">MTDYAEERRSEVEVLESIFADELTIISDDKLALKVEPEEQSPSEPCKALQTDVLSLLITYTPTYPDEIPLIEVEAIEGEISDEENSTLVTGLQSAAEDNLGIAMVYTLASYLKDSLVELVRQRKVRIAKEEAERHEKEEEAAIRKMQGTKVTNESFAQWRLKFEKEMADASAKEEQERLKTLPPKEREEAKKFRSKLSGRQLFEKGDPSLVTSDSGFEDEDGVEVDTSLYERTERLNLTDEDDEEDRLGPRLGELSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MUI1</accession>
    <name>A0A2X0MUI1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01777 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01777</name>
        <name evidence="2" type="ORF">BQ5605_C002G01777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY35543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MUI1"/>
    <dbReference type="STRING" id="796604.A0A2X0MUI1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY35543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="678" mass="76738" checksum="58F3DD7DD0A54706" modified="2018-09-12" version="1">MVIMTAECACELIELIPAGILHRVIHPIDPGRNLISNGNGNSDHRVEIPRFLTIQDKARDASQSVLHEPLHDWIILGYEGTRETLHLIDQGRGGLGVVEMRSSITPNDVNFGLLKVEGRILLWTYMPEHAISGVRRARALVHGRALLTIFKHDATFTASRVAEFTPQITRYKLKLDRALPSNTSSPPTPTYHSPKSSPEITPRPPLGMRLASDVSNSRYVTEPRSSNSSSRKEQCSDIYKAMVGLDVSDPDRSPPSAVCDRSNQPPPSRSQTPRSEVDGTLRNQMPYVSYAQKNRTQSSTTRPSPQGPPPPSRSQPRFDPTQCYPSPPASADRHAPSRHQPASSRSSIETATEERTAILYEVEHASPSRYSPTDYGASVYGGQAEDTYSIRHPPPARSISNHSIDSSTLVEEEGRRESSEEARKREERERFERELAIKSLREKREEEAKLRAREVVEKEHQARIEYEQRQKEREAWVLKAQKEREEKLRLVEMERRKKEEEAKREERRRVEEDQRKRMQDAATRVQKDQERLLMSQHALFKKLQDDEEALVRAQEKKKRQHELKVRFAQGKATSTAIGGTAILDGEVSVQGGNSIVWRRRWFELLADELVLFKSAAERIRIKAIAYKAIVKVVDSPEEAGVANSFMLTLEDGDEWTFFTDESAAKDVLLSALEVAAGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MV44</accession>
    <name>A0A2X0MV44_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C007g04789 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C007g04789</name>
        <name evidence="2" type="ORF">BQ5605_C007G04789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY63287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MV44"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY63287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="332" mass="37004" checksum="F7E1ECDE7BE60FD3" modified="2018-09-12" version="1">MNMTIAELLAFDVAPADASLHIELSKDEHTQYSTLSSTRCLVDARDTNFSLNWLTWWPIKLLISVATSSCSTQGRPMESSDPTRGEAGVGVRTQYSTFMRLERKNAYTEDGRIQEKLPERDKQYGALAQRYPHFGSLDGAVTAATPLEIGSLICFVPKRGMHSLSCDQTVYGEEALSIGIVTTNHCNQDTLASLVLLSNVVVQELRLIKKTCYSTHLIDGTMPFRMIDGRQVIESTSAHAEQRFAAFGACPACEMPPAEPLQAAQMPPRKQGAQLQQKGSLTTKQRASQQSKEGLFEAWSHAQHQPKRRAPQATFDRPPRARKRSERIFEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MVV4</accession>
    <name>A0A2X0MVV4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g02319 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g02319</name>
        <name evidence="2" type="ORF">BQ5605_C003G02319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY40069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MVV4"/>
    <dbReference type="STRING" id="796604.A0A2X0MVV4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050910">
        <property type="entry name" value="JMJD6_ArgDemeth/LysHydrox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480:SF6">
        <property type="entry name" value="2-OXOGLUTARATE AND IRON-DEPENDENT OXYGENASE JMJD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480">
        <property type="entry name" value="ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="150"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY40069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="450" mass="51175" checksum="2FF67C37D7A1CB28" modified="2018-09-12" version="1">MLPTTLDSHHSPATLKSPCPTRLSPAELSYSAFRTFLLNNEPCLLPREVVEAWPICQHWRLRPTSTTVVDPSSEAASTSTPNYEYLRANLGHYPLPPVVDQSCLRVTPDAPSAFGSLLDLWRNGEGRSLYLKDWHLPAIFESQVAASGVLNRDQSYGFYEVPGLWRDDWLNRYHLANSNDDFRFVYAGGADTFTPLHRDVFDSYSISTNIIGAKRWYLFPPELTATLEPMLAKAGRDSGWVNVEEWDTQQKEEFISKGMMVFVQEEGETLFVPSGWHHHVTNLSHPTISLNHNWINAHNISATYRSLAREGLRCAQSISDVKELLQHHSKNDWRPRWARCVSDLLDQSAGWGWSTFWAMTLFALKDCRHHPKETASSHWPAVTSDLQPPLQYLVVQVNLPEFHLAFQIQPLLADFLSREEAEHMYLPGLSELLACITDQLNVLEELAKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MWN3</accession>
    <name>A0A2X0MWN3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C001g00064</name>
        <name evidence="11" type="ORF">BQ5605_C001G00064</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY43809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MWN3"/>
    <dbReference type="STRING" id="796604.A0A2X0MWN3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05312">
        <property type="entry name" value="NAD_bind_1_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000182">
        <property type="entry name" value="NAD-dependent malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF32">
        <property type="entry name" value="NADP-DEPENDENT MALIC ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="10">
        <location>
            <begin position="75"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="9">
        <location>
            <begin position="300"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY43809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="589" mass="64709" checksum="5078F0402DCBDE95" modified="2018-09-12" version="1">MSTANGKIAPNVGLQGGVEPSNVGTKEVLVGRALARLRLRSTRRTKARVRIHRSEVFGRSIPGDLEKYTFLASLKSRNENVFYALVGSHMKELCPLIYTPVIGEPLDCPDSPKAKKRGLLTIIPGGRPRMPELFPDPPSPDTNTKPARALYLSAPDLPHLPEILANLKTRLPHDQMEIAVVTDGSRVLGLGDLGVGGMGISMGKLSLYVAAGGVNPKATLPIVVDFGTDNEKLLGDPLYVGMRQRRMSDADCEAWFEVFMKEMHQTFPNMIIQFEDFHTTLAFPLLEKHRERYPCFNDDIQGTGSVILAGAIRAFAQNGIPLKEQRILFFGAGSSGVGVAETISKHFELAGGMTEDEARNRFWLVDSKGLVANNRGDKLPTHKQYLARREEDAPKLKTLLEIVKHVRPTALMGLSTLGGAFTREILEFMAHINAKPIVFALSNPVALAECTYEEAVEATNGTVLYASGSPFDPVQFEGKTYEPGQGNNMYIFPAVGLGAILAQVKTIPEAIIHAAARALADSLNADEKERRLLYPDVERIREVTIFIALRVIRAAQQAGVDRNEKLRGITDLELNNYIRGSMYQAMLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MXA9</accession>
    <name>A0A2X0MXA9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00284 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00284</name>
        <name evidence="2" type="ORF">BQ5605_C001G00284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY45435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MXA9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY45435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="169" mass="17797" checksum="4AD1DFE9AAE4F69D" modified="2018-09-12" version="1">MEHTRFLARSPSSFPPRGFLKGELGGIARGCCHSYSIGASVLRRSFVVALNGCRAGVDGWPPGGGGKRRILKANTVRFKALTVRTGSEALSDPQSSRARRDNPASYPAAKCTSRPLSTGSKVGDARNVERQSSTSGTRVGDGGGDLDDVSVHVTRGQGARRRLCALTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MXJ7</accession>
    <name>A0A2X0MXJ7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C005g03354 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C005g03354</name>
        <name evidence="3" type="ORF">BQ5605_C005G03354</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY74288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MXJ7"/>
    <dbReference type="STRING" id="796604.A0A2X0MXJ7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF7">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="276"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY74288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="374" mass="39547" checksum="98F8BB4B41A5ABA4" modified="2018-09-12" version="1">MSSRRTLSPPPPTTLPFTDDTLTSHVVPTLVYTPYHIGVSATPADPTRSPASALIPATLGPRVARTGSIPSQSASLSSSSALASTVTTATTSASQYVWSPFNPGQSWDGGAPLRVLPPLPPGAAVSPPPPPPRPQSHSHSTAQGHLVMSSVASDSPNNTITSRAGSGSGSGSGRDTGATSAVSYRGKDERFDKSRSASLNHTLDPSTMIVTVARAEDESSPDDDHITFEAHSGSRIASNVTMSASGTVKGARVGVKRRRGEIDPGAIEGQYYGDKTCNRCRERRVRCDRAFPICGRCLKRREGCSYPDQTSARKRDDPEESDRVAALEAAVATMEQQLEAQRYDSDYDAKQTSPAASSNTPAWTVPTPARHFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MYB4</accession>
    <name>A0A2X0MYB4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Adenylate kinase</fullName>
            <ecNumber evidence="6">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate kinase cytosolic and mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C005g03634</name>
        <name evidence="6" type="synonym">ADK1</name>
        <name evidence="10" type="ORF">BQ5605_C005G03634</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <text evidence="6">Predominantly mitochondrial.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the adenylate kinase family. AK2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6"/>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MYB4"/>
    <dbReference type="STRING" id="796604.A0A2X0MYB4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006172">
        <property type="term" value="P:ADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03168">
        <property type="entry name" value="Adenylate_kinase_AK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028587">
        <property type="entry name" value="AK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001380">
        <property type="entry name" value="PRK00279.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001381">
        <property type="entry name" value="PRK00279.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011100">
        <property type="entry name" value="PRK14527.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="9">
        <location>
            <begin position="184"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMPbind" evidence="6">
        <location>
            <begin position="86"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="6">
        <location>
            <begin position="183"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="66"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="113"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="142"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="193"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY77424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="277" mass="30719" checksum="A5F8B4893BD381D7" modified="2018-09-12" version="1">MAPTSSNSGSDQLEHLKSLVSQLQAKIERLESQAGSKASEIKDTVKDKTGWTPAQHLRIVLMGPPGAGKGTQAPNIKDKFNVCHLATGDMLREQVKQGTELGKQAKKIMDQGGLVSDEIVIGMIQQQLDENKECELGFILDGFPRTVGQAQKLDSMLEKKQQPLEHAIQLLVNDNLLVSRITGRLIHPASGRSYHKEFAPPKKAMTDDITGEPLIQRSDDTAETLRKRLDTYHQQTDPVADYYKTKGIWKGVDAAQSPKTVWETLQKTFAEHAEKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MYQ4</accession>
    <name>A0A2X0MYQ4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C008g04955 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C008g04955</name>
        <name evidence="3" type="ORF">BQ5605_C008G04955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY78797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MYQ4"/>
    <dbReference type="STRING" id="796604.A0A2X0MYQ4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051859">
        <property type="entry name" value="DCAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847:SF7">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="474"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="521"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="176"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY78797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="763" mass="83931" checksum="AF118122223984FA" modified="2018-09-12" version="1">MSMPGGFYANSRTGRNDSSTTQAMMEAGEDEVAPANTGLSLFQGMPDDDDHDQDNDEDGWAAVDDMATLGSYTFSETSDDTSFNEDEEEEEEEEEELDQATEVAEDDDQDEADAETNGPSGGGALRIAFDPTSRQILIVDDNGNAAQLTHQHLRGTGTTLASIRRMILSQLVPGMRSRVMAGQGDDEDEEDEGEAAEDEDDDGEDSGGYDDPYWGPARRTTKNYYEIPKEPVPAGVRLERSGEFGPPPRKYAATERKFGDYSPNVSRILRERDLNVGRMPKSWLAHDLVPNNSGVEVAQLQAKVYSGQYSTDGAFFYAAAKDFKIYVYDTKEPPRTGNKSVIEATPTATRRNRLYGGTWEHRSSMKVIKTIQANPIACQWTVTDASLSVDNEWMLYASISPYVHLVKTGGGGNNGVWDLDEQQEMLDFANGSRRDVGGIWSVRFSNDGKEVVAGASSGAIIVYDIESKRSILNVRGHQDDVNAVAFADSASSNVVISGSDDSFVKVWDRRSMSGKQAAGTLVGHTEGVTFVAPKGDGRYCLSNGKDQGTKLWDLRKMTSNADFDRLRLDVKHFGIPNWDYRGGYYAKPRHQQHPHDCSVMTYRGHAVLRTLIRCHFSPAATTDQQYVYSGSSDGKIHIWSLDGTLVQKINRRYTHPLINAETGDYNDPFDSKLRSSKGKSGGMIMVRDVSWHPYRPELMSTAWCNGHGGECAFDLPGVCGMNLADGCVLSTGIEGDLALHAWKGPSGESLADRAERERLEASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MYZ3</accession>
    <name>A0A2X0MYZ3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C008g05055 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C008g05055</name>
        <name evidence="2" type="ORF">BQ5605_C008G05055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MYZ3"/>
    <dbReference type="STRING" id="796604.A0A2X0MYZ3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
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    </feature>
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        <location>
            <begin position="277"/>
            <end position="435"/>
        </location>
    </feature>
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        <location>
            <begin position="467"/>
            <end position="537"/>
        </location>
    </feature>
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        <location>
            <begin position="550"/>
            <end position="681"/>
        </location>
    </feature>
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        <location>
            <begin position="695"/>
            <end position="721"/>
        </location>
    </feature>
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        <location>
            <begin position="742"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
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        <location>
            <begin position="325"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
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        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
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            <begin position="479"/>
            <end position="489"/>
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            <begin position="550"/>
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        <location>
            <begin position="712"/>
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    </feature>
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        <location>
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        <location>
            <begin position="851"/>
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        <location>
            <begin position="893"/>
            <end position="902"/>
        </location>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SGY79150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="970" mass="103163" checksum="8B7F53330B4706BE" modified="2018-09-12" version="1">MASNPHPNSHPHPQHHGNNIYADPHNVDHARNIVVGSSYTMHYPIGPPLDVMHAYAPMPMPMPMPMNHMPMQPSHRPSVPTMPLQPITNTASSSFIWPASPPKAAAPNTPATAPWPQNVLPPPPSAATNPKLAAAATTTTKAARGGAAAKRKSITKHEAATAQSAALLLAPDYTANPAGPASSSDTDFKCSYCDKIYKGKHARSIWRRHLQDKHGIPLASQPRRTRWDNGTMLFSGARRACLSRPHKPHISTQCRTTRPRHVIRTEDIRVLSWSNANRPKSEEERRARTLDSKRRWARKNRGTDGRSAGGDTPGRGGSASFDGRDEGEWEDDQFGDEDGSSAGGRSRSNSASTWQESKTALARSGSVPTLGGAGRLQDEKPDRSSLRASQSTSAVPHASEIDPRHPQQHRGSYAHGPPAHLVQPRGSHLPHSPSSYYQAPLAAAVPIGGALSAPLFPQANEAEFYRSENPTSMMQRLGASIPRPASASSLPPPYAPAQSTSSASLAYYASRASPGRGSRTTLRRDPKSPIRTGSNTEDAAGVLLALKMASPSTSSILQSPVSATRSRRFDDDSDDDEEEDEDAGDLSLEANEPFSAFTAKQASRRTGGSRLVASGRGAAFASPTRDPPTSPEGSDSSTDNWSRNEGEASTSTMVDPTSSKRAGKKRSAEDSPPPYGSAQALVGLSASARKIRPIAGIAPNGNGQVAGRPLGPNSSYHQYTSLTATPTPAMRVTMESSPAMVYGRDLLEGGSIRRGPRHDHHHDDDDGDLEEDEPSRGGRVHDGSPSRAMRSHRNGNGPIEDASSSAPRAHHHHPYSHGYPSSASSARHYPQALHHHHPVGLTSDLGHFNLSSSSDPSHPSSSSSSMPPHPSSSSASFPHSTPGGVSTDYYRLRGSSPPSRSNGGSGYLFSSPAHPGISKQLGLHAQPGPGVLFSGETPGRNAAVDVLESRSKGMRLVEEGGSRAVLKLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MZB7</accession>
    <name>A0A2X0MZB7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BQ5605_C008g05175 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C008g05175</name>
        <name evidence="11" type="ORF">BQ5605_C008G05175</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MZB7"/>
    <dbReference type="STRING" id="796604.A0A2X0MZB7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000088">
        <property type="entry name" value="Splicing factor 3b, subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015016">
        <property type="entry name" value="SF3b_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038737">
        <property type="entry name" value="SF3b_su1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12097">
        <property type="entry name" value="SPLICING FACTOR 3B, SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08920">
        <property type="entry name" value="SF3b1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Splicing factor 3B subunit 1" evidence="9">
        <location>
            <begin position="257"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat" evidence="10">
        <location>
            <begin position="1057"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="57"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="117"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="247"/>
            <end position="291"/>
        </location>
    </feature>
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        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="22"/>
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        </location>
    </feature>
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        <location>
            <begin position="125"/>
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        </location>
    </feature>
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            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY79615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1279" mass="141628" checksum="B6A5D06F7A3BCD95" modified="2018-09-12" version="1">MSDSAADEIRAAQAARREAKRAAQATQRPESESNKVSMSSVSMDLDVYDGASKGSRFAKHDLSISAGPSRNEDDEQLDEYGNPKPVRLLDSFTAPKHLINEFADNDAEDPFAATAKSRQVASRQSEYHARRFNRESAVQADAFAMDDAPKTGGDDESTTYADQMRRAEIEREEQRVQRAIQKKQEEAAVAGTSESTENAVTAPDETPRGRQSWDVDEDDRPRASMVDALESGGTKRSGEWDDVNTQGKEAAAAAAAPKKKRSRWDETPAQAATAGSGAPGETPRRSRWDQTPVGVAQTPNAAGLYGAMTPFKGATGSNASIPGAGQLIDPRNRYLSDEELNQMLPTEGYEIVDPPAGYAPIRTPARKLQETPMAMNGGGFIMQEDAASASMLGITQELPTEIAGVGDLQFFKQEDATYFAKILGDQDESELSIEELKERKIMRLLLKIKNGTPPMRKTALRQITDKAREFGAGPLFDKILPLLMERTLEDQERHLLVKVIDRVLYKLDDLVRPYVHKILVVIEPLLIDEDYYARVEGREIISNLSKAAGLAHMISTMRPDIDHADEYVRNTTARAFSVVASALGIPSLLPFLKAVCRSKKSWQARHTGIKIIQQIAIMMGCAVLPHLKNLVEAVAHGLEDEQQKVRTMTALCIAALAEAAAPYGIESFDSVLKPLWTGIRKHRGKGLAAFLKAIGFIIPLMDPEYANYYTREVMVILIREFQSPDEEMKKIVLKVVKQCASTDGVQPAYVKEEILPEFFKNFMVRRMALDRRNYRQVVETTVELAQKAGVSEIVGRVVNDLKDESEPYRKMVMDIITQVVAGLGAADIDERLEVQLIDGIIYAFQEQSAEDYVMLEGFGTVVNALGIRVKPYLTQIVSTILWRLNNKSAKVRQQAADLTTKLAVVIKQCEEDALLSKLGVVLFEQLGEEYPDTLGSIIAAIAAIANVVGMTQMSPPVKDLCTSLLSISNCRPVAHLLICGYLLVSLAVPRMTPILRNRHEKVQEASINLIGRIADRGAEFVSAREWMRICFELLDLLKAHKKAIRRAAVNSFGYIAKAIGPQDVLSVLLTNLRVQERQSRVCSTVAIAIVAETCGPFTCIPAILNEYRTPELNVRNGCLKAMSFLFEYIGEMGKDYIHSVVTCLEDALTDRDLVHRQTSATIVKHLALGTAGLGDEDACLHLLNLLWPNIFETSPHVIGAVLDAIEAMRIALGPGVLLSYIMQGLWHPARRVREVYWQIYSSLYMGAQDALVPYYPTIPEISDERNDYEGRSQLLMMWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MZL1</accession>
    <name>A0A2X0MZL1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C008g05255</name>
        <name evidence="8" type="ORF">BQ5605_C008G05255</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MZL1"/>
    <dbReference type="STRING" id="796604.A0A2X0MZL1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044554">
        <property type="entry name" value="ANAPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014786">
        <property type="entry name" value="ANAPC2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057975">
        <property type="entry name" value="TPR_ANAPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957:SF1">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08672">
        <property type="entry name" value="ANAPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25773">
        <property type="entry name" value="TPR_ANAPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01013">
        <property type="entry name" value="APC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="7">
        <location>
            <begin position="410"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY79946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="749" mass="84891" checksum="E3C3E8C28AF6D072" modified="2018-09-12" version="1">MDIDVASLWRETAHQFDPPHYRGEATEDQISVAQAWPLCVAHLNPAAHAQNLHTDYFEPPVIVRAAQAVERAGLSDRLFDDYLLAIKDTFHVVQAEVLDCLDRFWTSSGDHRPLAVVQLLHRVGLILDRWQRPLSTFWPSSTALANYKRYCLNCLYAVLPPEFTQALGVYLRYLLHLSPPLGSLPPNHAHALSTLIPLLDRYDPLLFGLIYEEIEKKVARDCKGVFDQLQLQALLGWVNGPVLNWVAGLYEKTLSDGTAGSEEAKKLLKPTFTRFEYHVHKTLGVLRASEMFDIIVNFPRSTPALEDLKVCLLKTDQRAIIVNKLRQLNEQRLLHPGVDTKNIISQYIASIRCLRLLDPQGVLLSRIADPIRQYLRAREDTIRCIVSSLIEEGNELVKELAVSGAKPVQDAKDEAENYNDPKWTPDPIDAPADFRKSKGSDIIQLLVSIYDTKDVFVKELQVLLAQRLLAVKDYAFEKEIKNVEVLKVRFGEASLQGCEVMIRDLQDSKAIDVAVHERNQGVPLHATIVSRLFWPSFQPAPLKLPGQLGRAQREYDQAFTALKPEKKLRWLPQLGTINITVDLRDRSLTLDVTPLQASVLEVFQLRTIWTADSIGDELRIIDTVAIRNVLYFWNNHGVLKSLPDDEWKLLEFTDAATEKAASHVIEEEAQAVQSVEVQQIEQMRVYWQYIKGMLLNLGALPIARIHSTLNMLVPTYKGKTTDELVAFLDAMRIEGLVEKTVNGSWKIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N045</accession>
    <name>A0A2X0N045_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g04070 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g04070</name>
        <name evidence="2" type="ORF">BQ5605_C006G04070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY55748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N045"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY55748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="54" mass="5393" checksum="06D77B8CB45CD1C8" modified="2018-09-12" version="1">MNMNGSTSGSTDDLLSSALNSDTASSFGAATAGDAPLPVQQHIERVVGRAPDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N1E4</accession>
    <name>A0A2X0N1E4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C039g11790 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C039g11790</name>
        <name evidence="5" type="ORF">BQ5605_C039G11790</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000060">
        <property type="protein sequence ID" value="SGY90135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N1E4"/>
    <dbReference type="STRING" id="796604.A0A2X0N1E4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03755">
        <property type="entry name" value="proteasome_alpha_type_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="4">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="268"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY90135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="303" mass="33392" checksum="1EDB3E5A833DB114" modified="2018-09-12" version="1">MSRGYDRSLVTFSPDGHLFQVDYALEAVRKGTCAVGVRGKQVVVLGVEKKSVMQLQDPRTVRKTAMIDDHVCLGFAEGEGEGVGLMTRRLLGGGYPRLERRVVRLTLDGLTADARILVDRARMECQSHRLTVEDPVTVEYITRHIAGIQQKYTQSGGMRPFGISCLIIGFDHDDPTPRLYLTEPSGIFSAWRANAIGRSSKTVREFLEKNWVADLDKDEAVKLAVKSLLEVVQTGAKNIDLAVMTGHGQVRNLTLEEIEAVVAEIEKEKEAEQEKKKNRLAATAASREAMTVGPSVTQSLGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N7X5</accession>
    <name>A0A2X0N7X5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C024g09827 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C024g09827</name>
        <name evidence="3" type="ORF">BQ5605_C024G09827</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ26067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N7X5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="340"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ26067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="422" mass="43055" checksum="2A3C5BB0E919F1F5" modified="2018-09-12" version="1">MSTFSDIGSMTISVSTLINIALTGALVAGVYVLAQNKGNHKATNAAGGGTSSGKKNKGNKKKVNAAGGPAVAETKVASASTSTPTSSNTSSSGKKAPTDGATGGTSKKKKKKQTTPAANAASTEPSYAEVVTPESPSTTSSIGAKSAQPPHKAPTSFADAAAVGAEDQTSANASNKKPAAAATDDYFAAAAAAAAPSASGTKKNKKDKQPVSGISAAEKHHDAKPSPEVADPALKDMRDEQHDPTVKVARVLKVVGGSIGARPIEDERWEEEWDGQGQEDDGWVVARSKKPTKSASSTASSSGAAAFSTSNPAPSAPKSVSGLTASTQAAMTKKQRENQAKAAKAAAVKDAAEQERLERLAAHQKQLERTRMLDQDVQRNKGKKSGIRSVSYPTSGPGSGPTKLQSGGMYASLDNDGKLIWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NBV9</accession>
    <name>A0A2X0NBV9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">assimilatory sulfite reductase (NADPH)</fullName>
            <ecNumber evidence="5">1.8.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BQ5605_C042g12005</name>
        <name evidence="16" type="ORF">BQ5605_C042G12005</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>hydrogen sulfide + 3 NADP(+) + 3 H2O = sulfite + 3 NADPH + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>siroheme</name>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.2" evidence="5"/>
    <dbReference type="EMBL" id="FQNC01000116">
        <property type="protein sequence ID" value="SGZ31799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NBV9"/>
    <dbReference type="STRING" id="796604.A0A2X0NBV9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009337">
        <property type="term" value="C:sulfite reductase complex (NADPH)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050311">
        <property type="term" value="F:sulfite reductase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004783">
        <property type="term" value="F:sulfite reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000003">
        <property type="entry name" value="Sulfite reductase [NADPH] hemoprotein beta-component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="entry name" value="Sulfite Reductase Hemoprotein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045169">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010029">
        <property type="entry name" value="PRK13504.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493:SF47">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="Nitrite and sulphite reductase 4Fe-4S domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="Nitrite/Sulfite reductase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrite/sulphite reductase 4Fe-4S" evidence="14">
        <location>
            <begin position="2"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Nitrite/Sulfite reductase ferredoxin-like" evidence="15">
        <location>
            <begin position="184"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SGZ31799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="412" mass="45738" checksum="039CD89D81DA53FD" modified="2018-09-12" version="1">MPQTSAYAEIWLDKKQIVGEAVKDVEPLYGEYYLVSCSGLPILDPSLQIAIAVPPTNDVDVYCHDLGYIAILDANKELLGFNITIGGGMGVTHSMKSTYPRLADVVGFCTPEQGLEVAKAVLTTQRDNGNRANRKNARVKYTVDRMGIDAFKAEVEKRLGYNLQPARRFEFTSNVDQFGWQTGHDGKKHFTCFVENGRVQDEPGRPYKTGLAAIAKAHKGVFRLTANQHLIISDIPVEEEKTIQSILSKYNLDKVDFSGLRLSSAACVAFPTCGLAMAESERYLPVLIDKVEKVMEEEGLRNDSITMRMTGCPNGCARPWAAEVAFVGKAPGTYLMLLGGGYWGQRLNKIYRESVNEEEILAILRPMLKEYALERNDGERFGDFVIRKGYITATESGKQFYEGMAPGMEVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NMT8</accession>
    <name>A0A2X0NMT8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C010g06101 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C010g06101</name>
        <name evidence="6" type="ORF">BQ5605_C010G06101</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NMT8"/>
    <dbReference type="STRING" id="796604.A0A2X0NMT8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF1">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY14207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="323" mass="34643" checksum="F6F59F62F3E0E719" modified="2018-09-12" version="1">MSIPPNYHGPINANPSSGETTISIFGFIPSRALASIAAIVFALGLLCHVVYLIRAAELIPSTARLVISVNDVPPDQIAGDEVISVLVGDWMLGGYIVRILAHYHPFLVSFYVAQYFLIVYLALGLAIKRLPVTLAHGLLSFPPKIFIIIFIIADIVTTAIQITGAALIGAAESSRTPGSVPTAITSAQANDILLSGLAIQSVSFLAFIYILSLVAYRSNQVRPHVLPPRFSAALIISSLLVFLRTVFRLAEVAQGVFGFASTHEVLFGILEFAPVALAMSIWAALSLDELLPLARANHEIEKWDGKKANYGGIEIVNTVTRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NMZ0</accession>
    <name>A0A2X0NMZ0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C010g06151 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C010g06151</name>
        <name evidence="2" type="ORF">BQ5605_C010G06151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NMZ0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="547"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY14350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="578" mass="64890" checksum="51C0FF351EC2CE5C" modified="2018-09-12" version="1">MARGLAQHGGWCGLQHVHLSPGLTTFCSLPLSVVYLDSKPSDHTICCLSCLLPVTHASVQSTSSPEMGSVLSSSATVQTQQHHISASSIAEDGRSTTLASRPTTSNSSNSMSHRIEEVQDEIRALHDAVRALPSTSRLSSSQKEIHVLYNLQRRLEKMQYCLRHGVRDDDLDSYTPPATRSNDRNDWNDFKTSRFFRCLLEKNGLEGKCSVCLPDSSQNRLLSITRRYSDRQIHHSDPYKVPKDFSALQAIGSRYWEQVKNSPELWEQWKEARASEARDRKETARPLKRWRIDSATISKLRRRYENAMNELVREDSALRFRLLRGQLEQAREQKNDRFIVSTLGGAAFMRRQGWDSDQQKDILVNFTDCANGTRFNQEQNEQYKMRANHGDVDKASQRVLCAWYSIIIDDHYSEQPFHGSAPTSCSLVLNICGRADQALRRRHQRNRSTQPYVLSKLTSYNQATLAKDPIALIVEFGNGLQERDFRSPTNGKKPTVADLRRIIPLMRQGGLTFSLQEEIGQGSFDRTRAEGTVTTGQLETEPEDQVSGSDSASASASDLGSDSNSNSDSDADLGAATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NP23</accession>
    <name>A0A2X0NP23_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C013g07353 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C013g07353</name>
        <name evidence="2" type="ORF">BQ5605_C013G07353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NP23"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="661"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="898"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="686"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="899"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY15380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="981" mass="106526" checksum="653BF53B211FEBD5" modified="2018-09-12" version="1">MNTTKPSLSATLIKRVGGRPVYVVAPPRRPSSKSPSAVAPRPKDSRSSLNSARLSSQGSLDDSKTSPEIRRSLSSLANLPADSSASSIESMSASNLGIDPAAKTSTERAPSLAATSLPVPQPKPKPPHHLAFEFRPLTQSTPCTVEHERFPAAMEQDRAGIYAPRARGGPMMRNITTQTVNEPVRKIISCTDSRAESEEVLALLGRSSNVSKGKAPKIDPLPSSTFDSPSSSFCVPSSLSFLEQMFSSPIARRTAVSPKRPASPGRRANMTQAEEEYSTSRAFTSLLTQQEAAPTPTPTPTPTPALDPPPPTAASEWSHHEDGLRRLLQGMGFNSKRARKRVSRPEGMIDWWEERQEKKRKREGKAQGQGQAEDRRGNGEVKGDGAEDGDGDEVFGAALPPCGQPNQNLELDDPMDVVAQMQQNGEEEARQDQDVAPPTRNDVADDDEVPDVDNMVEMRRLQHAGDDGLRRLLGSVDPDSPRSRKRAEPPPGMVSWTAVLTPRSPKKGRISDALIPKLDFKCATSSPAVDKQQHLAPQSTPPSSPGPASSSAGPNTPPPTQSVLSMMPRNLLDVNDSSLRRMLEDVKAGDKRYRKQTERLPSMLEWSQVKEMNRRTKVPASMATQVVKPKSARKRSQVEAQAVPADVAADLGKHATPVAPKEPVLAWHPPTPSSNPKPAPDIPPTGDDEQTTGDEEQAHDCIAKASAGPLPQHLIVPRNLIAASDEGLRRMLSDVAHNGPRRRRKTEQPPGMVGWKMVRLTGRQPSSKPPSKKLKKSEAIAPISTGVVPVNEINIAAKVANGSEASKGAALQIPARDNDLIPPDSSQARDEAEFARLIEELRAGPDVGEELCQCTERLHKLADAIVQRRNDQALDQGLRRRRSDNYFEDGLVEVKAEDMENDEDAATEAEEDEDEEAVEEDELSARLVWASPGKTSGPKIMTWVKSAFDRLHWLGERVQVVDSTEDARLSQISADLGEGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NSB8</accession>
    <name>A0A2X0NSB8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C011g06588 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C011g06588</name>
        <name evidence="3" type="ORF">BQ5605_C011G06588</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0NSB8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037508">
        <property type="entry name" value="Msb1/Mug8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012965">
        <property type="entry name" value="Msb1/Mug8_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28093">
        <property type="entry name" value="MORPHOGENESIS-RELATED PROTEIN MSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28093:SF1">
        <property type="entry name" value="MORPHOGENESIS-RELATED PROTEIN MSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08101">
        <property type="entry name" value="Msb1-Mug8_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Meiotically up-regulated protein Msb1/Mug8" evidence="2">
        <location>
            <begin position="267"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="671"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="817"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1018"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1094"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1179"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1322"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1524"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="677"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="696"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="817"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="832"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="847"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1110"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1224"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1258"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1337"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1354"/>
            <end position="1363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY12729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1572" mass="167376" checksum="C2FF5149F93C9FDE" modified="2018-09-12" version="1">MVSFLARLTGAGPSNNGSGDKDGGRKTPSSSPTKSIRTNSIPLTSPSRSKSFIRLPRASTRHQIPAQATTATVPGSPSLASANPLPPLDLPSVNLLEDDGTTIHQAALATGLPTCPLSPRISTSAAGVRSSTETTPWVKLDDSDENASERATSTEHDSHSDLQQRDFALNVDDQKRLRRAMLSVEDVIVLLKECGVVIRERGLTTLGLFRPYRIGESRLKIDRLALLFYAFALDRSSVHRAADQPRNANDLFRVGGGKSKGAKLDAFKEEIKHANVHDVVGVLKWGLRHLVYSTSFAGKPSPQPLAWYDNFMLASEAGKHTTTAFSTLLLPSLPSSSQDLLTALLEVMQAVAAFTELNAMSAHRLSRQLGIYLFGLAPRGKAWSDWCELYTTWQNAGNALEGCLRAYVRSQPDLPERLRELVEAYPSPPPRVVKSQLKSVIKVEIEVKAEVWSRVMAVEVNDQRTGLVVALGTGGSAGAGQALSTGGMKRRDPVDVLVDAFEATHGSRLDDVEQGTKDVWKMIIEEAKNDGEPIAILSDETRRVLGLIGLDRGSSTWSALPLSDDARPQHGRQRSYSHGFESVSPLPRLDFANLTTPVTGSFPNRSVTHLSPSQLSGAPNRFSNSPSTAPQQASRIVTPNWSEFASTGFSDTVPANEFGLVDLSEAIGDGLRAKTTGGKSQDSRSSMGQRTPLKPSSPSRGHSSSTKPIRSLLNLSLTQIEDDFADVWLETLSDPGICSSWPSFLIAELQTDLVSSLETKIDHVLITEKLIELRPLSRTTSSSSSASIKGMTRSVSVAESTLSKRWRRASQLFSGSGSGFGSGIGKDGGSTSGHSTPTAPSPVSSSRQSRITMGKKSMTSAQPETIVEQARGNSVDLKAAAMLTSGATTTTAAVVRTSPKEEPAQILIKSVDPETTVTEEVQFRQVPEATDVPVKDIVEPTPPTNEELTFTDTQVEPILEAEAVPPVLTPAPTIVVDEAPEVAEDRATVEVTSELQPEAEVVESAHVAEQALPAISEDTTAVLPPSTADDSILEHPKKLGDTPSDDNPVVPAFRAEEGVGPHNGLKGTHGDHSASQIEVPHSQSVEDLEALVPHQRSNPPHDDLPGGQIGNRQGKPNPQSGLCLSAVHNESFDPAHGDHTGQEIGIARPASVEGIDVAALNDQKVETVSKTEATTPLVSSVALPAEEPVGNEQSEMVAEEDSSIPSGGGDSLSVLSSEVMRARTLSQTSSSTIGASPSKESSPGSTTSKRFLGGMSDILRRKTSAEKAQAKLEKEEEKKTQRELRQLKDDEKLSNSNRNKETKVPTPVSSVRARVLELEAERAKAEASVESPIRRSFSGSFQGMTRSESGGMAPPLSSSPESPTLARRSLKLPSKIATLAEGASIATVAGDAAAVVVASGVSASPQPQEFQHLAVKAPKTLDQLPSPLPSPSPVLEEECSTPLLATDPTPDSTAVFDHHPPQLNFGEVVNVAPPTPIKGNDPFIADFNGTPRAKPPLFAGHKEPSLDVEPGSSILQLIPATTVEATTAEEVEQDSHSFDHPPASLPSSASDYSIAETATSFKTADSEAFFET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NTG3</accession>
    <name>A0A2X0NTG3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C011g06599 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C011g06599</name>
        <name evidence="2" type="ORF">BQ5605_C011G06599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NTG3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY12782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="359" mass="39154" checksum="BB91C37C945D208E" modified="2018-09-12" version="1">MNMTIAELLAFDVAPADASLHIELSKDELTHYSTLSSTRGPTSSCPTQGRPMESSDPTRGEAGVGVSNTEEGRSTAHSCVLKGLVQSMGPSRCEDMAGTTRSFCWTGGGQDGRIQEKLPERDKQYGALAQHYPHFGSLDGAVTAATPLEIGSLICFGLKCGMHSLGCDQTVYGEEALSIGIVTTNHSNQDTLASLVLLSNVVVQELRFIEKAYYFIHIDGTMPFRMIDGRQVIESLGPSATTYRSTTDLTSCYPDERLISTSAHAEQRFAALRSVQCPACEMPPAEPLQAAQMPPRKQGSQLQQKGSLTTKQQASQQSKEGLFEAWSHAQHQPKRRAPQATSDRPPRARKRSERVFEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NU83</accession>
    <name>A0A2X0NU83_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C019g09028 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C019g09028</name>
        <name evidence="3" type="ORF">BQ5605_C019G09028</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY24263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NU83"/>
    <dbReference type="STRING" id="796604.A0A2X0NU83"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050852">
        <property type="entry name" value="Queuine_tRNA-ribosyltrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46064">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE ACCESSORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46064:SF1">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE ACCESSORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="tRNA-guanine transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="2">
        <location>
            <begin position="34"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY24263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="516" mass="56325" checksum="A757D6E25106BA10" modified="2018-09-12" version="1">MTAGTVRSGSSSSSPSSWPKMTFALDDAPANSPRSGGLSFTRSESEVRCISTPAVMAYTRKGAIPHLTRDNVARLPNEMVHLSLEHFLDISPPIFTRAPMSLHRFIGLYETPTYRQPILALGLRDTSSDKPLAPNQDKLIMAATLQGSAKISSGAVCDYLLAQPTDIVIAPSDEQRGSLSSKKLDKVIRRGLQWASDFIAKADGRANVFVPLVGGQSPIGRSEFSNALLGDTPNQASQPAKVEPGRKPLDASINGYVLTIDSTLPGLHELCHASLDPLPSHKPRLALGVSGPHAILKTIQEIGLDIFVDEWSSQISTVGVALDFSFPVPHEADTLGHDREHQRPIGLDLYDPAYDRSFIPLSSSILAPSPEALHAFGPIPPTRAYVHHLLQAREMTSYVILAQHNLTVMHRFFQNIRDVLRRGKEEFDLQVQRFNDTYEDQQVPEYRGRGYAVVMNATREFDRVNKERGKGSLRDKLAKDAVTLAEGVATKMTPLPSPAVPGVVEVNGGSKRQKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NVW8</accession>
    <name>A0A2X0NVW8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01264 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01264</name>
        <name evidence="2" type="ORF">BQ5605_C002G01264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY31821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NVW8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="811"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="960"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="440"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="816"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="902"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="914"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="968"/>
            <end position="979"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY31821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="979" mass="105267" checksum="6AFB752335E0C27C" modified="2018-09-12" version="1">MSHSSADPPVPAGSAEVIIPRLPPPQFEPREKGQPRLTLFTGTTGEFEALNRAFKRPRHVQSEPVPSPSLETAGVDSNQGCTATVDQQQTSATAASESAGAKRPRLSLSTPSQTSRTPIVRQLTPGDQDQSAQPLRSQGVALVNEVLTRIVLFRPGNTERRARWGGDPRFWDEYSAIECALVTFTNDKAAHAVFSPTLLVEFKKTLLGQMTLAQAISFSWQQFETAMKRVQSLINHLRALYCSTCLCRALPLVVESQWIDIVRAPSNPHSTSPQNFPPPTHEPPPLPSTAHSTTSRATPESAPGNQDCSRFRPSPPTSSLLNTEQPSTSAVSSPTHSLGQNLPAIAPSSVILPPRHRSRLGIPGSAASQGPSPPPTSTTSQSSKQGFNSNPSLGVSSGIVYGTNASWNASPFLSNSAREPPTQGSPLNRSPPRFQSQFGPSPSSLPPRSSHIQESSHWRQPRQIPQSRPGPVHPHPQGLSTTHRSPPLGGSAGPFPPQQLQMPIEAELERIYQMGISAGRCYEHEKVHGKERARAEAETPSQASAPPRLSQDFAQALAQPQASMQATEKMQSLAKAQVQASIRAPAPRVAPPPNDSGHGQMQSPAPIYVAYRGRLPQNSGPNMPQMINSRPMHFSADVSPTLPHDQLVGVPARVPSPTEQFRASLHRPPAFIEGTEGLPEHFGPVYVLLNLAATPDVAKDHHQLLMRVVPFYNAFADHTAEQLKLGRMSLQAFNEGTLRVDQTEQAKMMGGFEQAKYADRVCEILARAIDTWHAHVTKILGPTPVPATPRSRSQSGEGQGVQLLQNGQAGVMPSISHPTRLSSSLGTSSVPPAGNDTGAPLDRAIKRTHRASRSESNVAVQQNPPPSNNAGAAPRRVSGPSPVPAEKNLAVAPQSRPSSRLSPPPQPVQPPPTARDRLRAKREELVPALEKVIQAVESSQTQSSAHEDYAALVQRFKKAKIERERQKSAASAASASPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NW52</accession>
    <name>A0A2X0NW52_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-splicing endonuclease subunit Sen34</fullName>
            <ecNumber evidence="4">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C002g01364</name>
        <name evidence="8" type="ORF">BQ5605_C002G01364</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="4"/>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY32448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NW52"/>
    <dbReference type="STRING" id="796604.A0A2X0NW52"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016690">
        <property type="entry name" value="TSEN34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059049">
        <property type="entry name" value="TSEN34_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26577">
        <property type="entry name" value="TSEN34_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017250">
        <property type="entry name" value="tRNA_splic_SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TSEN34 N-terminal" evidence="7">
        <location>
            <begin position="9"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="161"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR017250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR017250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF26577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY32448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="361" mass="41047" checksum="C7E29FD98C99D3E0" modified="2018-09-12" version="1">MSPPEQERIKIYVSNQRGYIWDVRDLQTLRVNHHICGVLSGTLPQVGQQNVFLGIPLLLLPDETVLLVRNNLAVLIDDRAAHHPPTTEQATHYDFQRQSAIQAQQKHIRQFEQEKKVKMAHLFKDKIEKKRLLKSEKNQPVETRANDEEVASAEIQAETGVWQLNVPDLEPNGRSKSPVASTSSAPTREANEDLSGVPYTIMIQGSSTDALWHDPAWASYLTLEAAKEAGVWDYPTNQLQQSRSNVFEDLWRKGHFMGGGLRFGGDFLVYPGSFFPKRFQYDAVWKANRNVGYYISLGDPLRYHSHFTLTVLSSLDQKIMPLDLISYGRLATAVKKAHLLASWDEKEDKVEYFSLEWAAMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NWH6</accession>
    <name>A0A2X0NWH6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycerol-3-phosphate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="9">1.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C012g06871</name>
        <name evidence="12" type="ORF">BQ5605_C012G06871</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 9">
            <text>sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.8" evidence="9"/>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NWH6"/>
    <dbReference type="STRING" id="796604.A0A2X0NWH6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141152">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000004">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017751">
        <property type="entry name" value="G3P_DH_NAD-dep_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03376">
        <property type="entry name" value="glycerol3P_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728:SF8">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)]-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="2 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal" evidence="10">
        <location>
            <begin position="16"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal" evidence="11">
        <location>
            <begin position="214"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="21"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="290"/>
            <end position="291"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY16433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="363" mass="39406" checksum="32A3C410138F1D5C" modified="2018-09-12" version="1">MAFPLTSPAPPGGKWKIAIIGSGNWGSAIARLIGINVQAKPQLFDPEVKMSQPHLRDHWRAFTLAFKGRSLVQQFNESHENVKYLPGIKIPHCVVAEADLVRSVQGANALVFVTPHAFVPGVCKQLRGKVDPNCRALSLVKGVEVSAEHISIFAQVIEEQLGIPCGALSGANIADEVARDAFGETTIACKDQQEGQRWYEAFHTPTFHVQITDDVVGVSLAGALKNVVAIAAGACDGLGWGNNAKAAIMRIGLLEMRKFALEFFDTARPETFVYSSAGIADLITSCLGGRNRKCGEAFVKTGKSFYVLEREMLNGQKLQGVQTAKEVHEFLKARGRIDSYPLFHAVYNIAYEGLPPAKLTAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NWJ1</accession>
    <name>A0A2X0NWJ1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01534 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01534</name>
        <name evidence="2" type="ORF">BQ5605_C002G01534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY33731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NWJ1"/>
    <dbReference type="STRING" id="796604.A0A2X0NWJ1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="399"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY33731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="421" mass="45545" checksum="06E7E92C7E70C26A" modified="2018-09-12" version="1">MAPAPSPASTRSSRKRASSVGSSESSSSSSEPTPPTKKRATGTKVSDKIAKKELRMERNRSKFMHILRANGRTQGRTGLWRQGQWAGVAAQASRDRKRVHQESLESKIEHLERQLAQALSGSATSSPSRGRSITPADSQHLAEENETLKSELETERRQSAALKGRLGALEAKFLRLEGLLASPSSSTSGAPPVAPTSLPMTSPPSLLSTLPSPSLIRLPFSLALDNLPELPHVESTVSNPAASSNHGLATDAMDVLDLAKDESLVDNLSLSAREASSLPRRLSKSSLSTERASRQLHRMRRLQLKANPNPSLHEILSAISIRPRLPPSPSMARPSTAPGPTGLRASTPSPQLLAATILSTLTRGSTRTPLTMMQPRPSSLLIRSRRVRSLMISLARRSRTTCSLTSSTRTRSRYQPFTKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NXD2</accession>
    <name>A0A2X0NXD2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g01856 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C003g01856</name>
        <name evidence="1" type="ORF">BQ5605_C003G01856</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY37669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NXD2"/>
    <dbReference type="STRING" id="796604.A0A2X0NXD2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY37669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="288" mass="30255" checksum="BA4B604A1171DF7D" modified="2018-09-12" version="1">MQHAVSESVPICAKTNACPVVANVVSICNSFGACGFTCNGVLQKSGGACACDPTQCLRGARATLICNTSRVCDLLCDAGFSKVNGVCTPTPCVPSQYPQANNARSICSHDRCNFQCSAGFSKVDGKCTTVFNPAKVPRGARATPICIAPGACNLLCCNSGFTKVDGQCVRPPCDPYQNPSIAYGTAICSRDKCDVQCNDGFRKSNGACVSEATVASVQACAAYCLLRSCASFAFYDGNQCRIQLESGGFERFRFVGEVVHGIPGQCADLAKNVPIRAAKQGCTNLQVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P1K3</accession>
    <name>A0A2X0P1K3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C002g01302 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01329 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01329</name>
        <name evidence="1" type="synonym">BQ5605_C002g01302</name>
        <name evidence="1" type="ORF">BQ5605_C002G01302</name>
        <name evidence="2" type="ORF">BQ5605_C002G01329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY32007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY32190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P1K3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY32007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY32190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="74" mass="7791" checksum="AA055E5F469F9730" modified="2018-09-12" version="1">MEGPQGEKVAGILGARVNPANLAQSLPPSVPAGKMKTWWRLDAFTNEDGVITSPSGPRKSVGFTESCIPWPAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P2N6</accession>
    <name>A0A2X0P2N6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01789 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01789</name>
        <name evidence="2" type="ORF">BQ5605_C002G01789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY35663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P2N6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="427"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="577"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="653"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="671"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY35663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="823" mass="86577" checksum="E7C229D85F733880" modified="2018-09-12" version="1">MGNPLGSHPSQRGHGWTKLPRPIHSKHSDPASVVPTSSLAMGSPVATTTLSTSSSGASLSSAPSSSYSSPAQSFSSVTPINTSPTVKWKARDAVAKRVQESDEEDELDDDLDDDLDDDLDDDLGEFGYSSARRRAGTRETLIDILNSGPPNWMQNPSRESVADNSSPRVKKRSGLFARTKQSAGISSHQPNGGTSESIAAALRKSIRISRSSGSLFRTGRVGSLGNVVTGSTSRMTKAQEQALAADEFARSLDPHTRKISLHMAESPGSESLMSFLRSSNPDEGCYTPGGSSHMGSPFQLPRLKPTSVGSSDKVQDVHESAPSPTRVFFRDLKVALEGNPMMTSQRGKRSTAGAPNSSGEWDAGMPEDASLAAQWVSGDELSRVDSLGVAEEEILASPPRSDPSTPRHMSYTAEELEKSPGARRRSIIATSSAGGSPISPSSSEGSSTTSRTTSQQSTSTARRISPNPTPKVEDTVSSLDHKPFERKYEPKHRAEDDTGPIATGESPIKGRPGSGSIASPGGDGSPFGRKSRHGVGSTWQKSDSSPCNKPRTSSSTPAMIPLTKQGFPSVLPLVLSASSTSPSRTPVESESSSKLDAAPDPTSKTIYTTKPRPENLIIPATSSVNSTCASDQEMPTSAGCSPESGSRRRPPRRITPPPKTPLPNAPGGSGAQVQAGSAGAEESPTKEEENEDSATDAVLEELPSGQSDGSSPDAWTSTREGQHSLSTPSNDPKYASGMEVISAPTPMHPRLLSALIELRTSMGETATLDLPEAATALELVLPTLCGMRTHFRNAINLLEVIIQLSAADHEGTEGSVVECLLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P4U4</accession>
    <name>A0A2X0P4U4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C003g02511 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C003g02511</name>
        <name evidence="8" type="ORF">BQ5605_C003G02511</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GOT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY41421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P4U4"/>
    <dbReference type="STRING" id="796604.A0A2X0P4U4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000137">
        <property type="term" value="C:Golgi cis cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045176">
        <property type="entry name" value="Got1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493">
        <property type="entry name" value="CGI-141-RELATED/LIPASE CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493:SF9">
        <property type="entry name" value="GOLGI TRANSPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY41421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="141" mass="15735" checksum="93840BC861A5191B" modified="2018-09-12" version="1">MHKVGLTSFGAFFMLLGMIMFFDGALLALGNILFIAGLPLIIGPRKTFYFFARKQKLRGRNGVATRSTPFCFVAGVILVFVKYPFIGMLIETFGFLNLFGDFFPVVLSFLRQVPVIGNFFSLPVVRQATDRIAGVRRQSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P4W4</accession>
    <name>A0A2X0P4W4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C004g02981 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C004g02981</name>
        <name evidence="6" type="ORF">BQ5605_C004G02981</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY69253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P4W4"/>
    <dbReference type="STRING" id="796604.A0A2X0P4W4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000196">
        <property type="entry name" value="Cell division control 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="40"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY69253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="410" mass="46933" checksum="3B51513F1517C15F" modified="2018-09-12" version="1">MSDEYHQAATAATNVVKKKLAGYVGFANLPNQVHRKSVRKGFHFTTMVVGESGLGKSTLINTLFDTSLYAKKSVPAPHHERPKTVAIESITADIEENGVRLRLTVVDTPGYGDFINNEDGWKPILDNIEARFDAYLEQENRVNRNKLVDNRIHACLYFIESTGHSLKGVDVEFMRRLHTKVNLIPIIAKADTMTDDEVMQFKARILSDIAHHRIEIYQAPQYDGEDEETIAENEEIVRKIPFAVVGSDVVVATQDGRSVRGRAYPWGTIEVDNEDHCDFVKLRQMLIRTHMEELKEHTNTHLYEKYRSDKLLGMGVTQDSTVFKEVNPAAKMAEERALHESKLAKMEAEMKMVFQQKVNEKEAKLKQSEEELYARHREMKEALEKQRLELEEKKRRLESGRPLTPEKVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P5D3</accession>
    <name>A0A2X0P5D3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable vacuolar protein sorting-associated protein 16 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C001g00136</name>
        <name evidence="6" type="ORF">BQ5605_C001G00136</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Essential for vacuolar protein sorting. Required for vacuole biogenesis, stability and to maintain vacuole morphology.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the VPS16 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY44269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P5D3"/>
    <dbReference type="STRING" id="796604.A0A2X0P5D3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.780">
        <property type="entry name" value="Vps16, C-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016534">
        <property type="entry name" value="VPS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006925">
        <property type="entry name" value="Vps16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038132">
        <property type="entry name" value="Vps16_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006926">
        <property type="entry name" value="Vps16_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04840">
        <property type="entry name" value="Vps16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04841">
        <property type="entry name" value="Vps16_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007949">
        <property type="entry name" value="VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps16 N-terminal" evidence="5">
        <location>
            <begin position="8"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Vps16 N-terminal" evidence="5">
        <location>
            <begin position="116"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Vps16 C-terminal" evidence="4">
        <location>
            <begin position="586"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR007949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY44269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="918" mass="101391" checksum="720FBAF6864832A2" modified="2018-09-12" version="1">MATIAPVSASWESLGETFYRKQEVYALPWRDSLGDLCNYIIASAKNAGPIALSRDERKPVLLGRNQTTLARPKIMIYSCAGLLLQTIPVRFQLLCGLSREQRRLIWACNSYFSRQWESSNRIVALGWTSSESLVVLVQDGTYRLYPLSTSASPSPSSSASASSSSTPTYSQHTLGAEAQDSGVLQAKIYEQGLVAFLGNLTFVEVKGWPATNALTESGSSGVGSASRSGGGGGGKVTPLAAVGLNEPPSCWGVVEPELSNTRGVEVLIGTGSTVLRLDEIEVQDQRLNRGPFLSITPSPNAHFLALITAGSSPQLWVTSSDFSRSLSEFDLSGEGESGPPNQVVWCGNNTVVVAWEKTVVMVGPFGETLKYFYSDPVHLIGETDGTRIISSESCEFLQIVPQSSQDVFRPGSTSPASILYEASELFDRRSPKADEYVRSIRVELVGAVDTLIDAAGREYEPMWQKKLLKAAAFGKGFLELYNPSDFVAMTKTLRVLNAVRGFEVGIPMTYDQYQTHPPSHLISRLTSRSLHLLALRISSYLGLSPAPVLKHWAQAQISSSPTSLTPTEEAHLVSLIVSKLSDQADISSADVANTAWQLGRSSMATKLLEFEPKGSRQVPLLIKMKQDELALTKAIESGDPNLVYTVLLYLKRSHALGDFLRFVDHKPTAAALLQILAKDAQDYELLKDFYYQDDRRKESALLALEESLPIESTFQDFGDKVAKVRVAAKSFGEDKDCAFENKMVEDHIRLLVFQQTLESETPSLPSLSPSFIGLSLNRTIHQCILLSQPQKADKLKSDFKVPDKRFWYIKLKALVEAREWTALETFAKSKKSPIGYEPFVNELIKNGAQRQTIGYIERCEQRTRVDWYVKTGEWVLAGQECLRRNDRNRLMDLKNKAPNTIIAAQLHELLEEMNNAGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P5K5</accession>
    <name>A0A2X0P5K5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">cystathionine gamma-synthase</fullName>
            <ecNumber evidence="7">2.5.1.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">O-succinylhomoserine (thiol)-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C001g00335</name>
        <name evidence="10" type="ORF">BQ5605_C001G00335</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of L-cystathionine from O-succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2-oxobutanoate, succinate and ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>O-succinyl-L-homoserine + L-cysteine = L,L-cystathionine + succinate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20397"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57661"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="EC" id="2.5.1.48"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-cystathionine from O-succinyl-L-homoserine: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.48" evidence="7"/>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY45756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P5K5"/>
    <dbReference type="STRING" id="796604.A0A2X0P5K5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003962">
        <property type="term" value="F:cystathionine gamma-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000094">
        <property type="entry name" value="Probable cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000063">
        <property type="entry name" value="Probable cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051750">
        <property type="entry name" value="Trans-sulfuration_enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699:SF1">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="188"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00051441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00058439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00060510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00066530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY45756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="732" mass="79677" checksum="782822E7B8D3CC0C" modified="2018-09-12" version="1">MPGLNTSSYGVGPPPASPLGSVIPAHTPHAVSVSLPTWQDNVAYEEGEQRIKDAMTSGYPRFYIHHQIQQLADLAIAKFGQANEACILLPTARTAQGCVSFLASREPPVQSRVVEWPVAAAVSLPSDDDNDVDALAKRRTIHLQACFFDEAHFSIAKQYWQHTGDGISSRIAERCLILLGELEAEGAAHHHSRRQSQTSPLIASNGEASTSSSSLGTHSKSSAGRYGGKAGGGRYGVVKPSSTPTGTATPTALAAKLRYSIASRPRNGTYSDESEPALMTSSLDALPPREALAAADQDEDVLTRYVEERYGRNLDLSLAPLAKLAMRRRIAGVLRETPGQAIPVERIDKTPDGEESTRGVASLTERDVWLYPGGMSAIFHSHQLAMGAREKDGKPIGKSICFGFPYTDTLKILEKWGPGCEFFGRGLSEDLPALRQTLEKANPPILAIYCEFPSNPLLRTPPLTALRELADEFGCMVVVDETIAGFVNVEVLPLADIVVSSLTKVFSGDSNVMGGSLVLNPKSEQYASLKAVQEATYEDFYFDEDAIYMERNSRDFQQRIAQENYNAETLCEYLRSRRAPGPCPTGVIDPPEVSRTGGVIKEVYYPKYINPEHYTASLRTPSEPYASGFGALFSLTFTSLQASAAFFDALPCYKGPSLGTNFTLACPYTILAHYTETEWALKWGVEKGLVRVSVGLEDVDLLKQWFEQALDKAEQAEANAKKLSDSVSTIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P765</accession>
    <name>A0A2X0P765_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">H/ACA ribonucleoprotein complex non-core subunit NAF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C001g00935</name>
        <name evidence="10" type="ORF">BQ5605_C001G00935</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY50886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="P:box H/ACA snoRNP assembly"/>
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        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:rRNA processing"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
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        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
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        <property type="entry name" value="Naf1"/>
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        <property type="entry name" value="Transl_B-barrel_sf"/>
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        <property type="entry name" value="H/ACA RIBONUCLEOPROTEIN COMPLEX NON-CORE SUBUNIT NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX NON-CORE SUBUNIT NAF1"/>
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        <property type="entry name" value="Gar1"/>
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        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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            <begin position="68"/>
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    <feature type="region of interest" description="Disordered" evidence="9">
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    <feature type="region of interest" description="Disordered" evidence="9">
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    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="802"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="17"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="77"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="9">
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            <begin position="158"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="196"/>
            <end position="205"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="223"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
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            <begin position="276"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="434"/>
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        <location>
            <begin position="445"/>
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        <location>
            <begin position="462"/>
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        <location>
            <begin position="562"/>
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        <location>
            <begin position="814"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009801"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00021438"/>
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    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
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    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
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    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY50886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="831" mass="88211" checksum="98C20270844C96B3" modified="2018-09-12" version="1">MESETQFVDLTGANEEPQVSSGVANRSSSETKQPGETEMGEIIDLTTPTASTAEADNEMIVVVVESEAQAATDGVHAASTTASTTDSSGSTLTAAEAPVQSNSSNPTSATDSPTNNNLTSLPNDITHILQLGVADPDPPESTTDYAQLVKDLKAKVMQSRNPNKAKNFNTAITVDDDSSMREEGEEREEELAQVENEMKEQGVERDEPEQGSNATQVNAAADESSEAEEEAGEESSSEESSSDDDSSSSSSDSEPTQTTRRQPNRQKHRQVMIDSDQSDLSDSEDPNPSGSSKKVPKTEHELDEDTSVPSLPEIESLPETVDIVRFGVVQNLIENVVVIRADTTGSYRVLDQGTIVCWEDRKIAGTIFDTFGSVLQPFYSLRFPATSPPDPATFTASRPLCYAPTSAHFVFTRELQAQKGSDASNVWDEEVGEGEIEFSDDEAEQEYKRAMKSEKKGKKKGNASVGGAKASTLGSSLDGFKSLPQKPSGPLPEIDEEGPYNLVQRPKGLHLMGTAPPSGPEGRQMFERDTGRTVEGEKEFEFSDNDEEDGGVVKNEGGSEEGGDRHDDEEMDDAKQAELARIMAGPPGRGGKRGRGRGEGGGGRGHDRSSRGGGGRGRGAPNEGRGRGRGRGRGAHNPLSRSDRPPQPGGGDGDDQRRQVALLPNRAPMGLPMRPMVMGEFGAPSPMGLPQNFAFGLPTNHHLPAPPQQQMFNFAPQAPMMPSSPIPGMYNPYFQPQPTGPYPNLPGLSYAHPQPSFTPDFGAGAQGAYNPQFFAYGPPPLNAMMGGSGQGSKGAGMMMGTGPYGYVPPPPQGQGPGGPGAGRGRGRGRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P7U7</accession>
    <name>A0A2X0P7U7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C006g03882 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C006g03882</name>
        <name evidence="25" type="ORF">BQ5605_C006G03882</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY54492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="447"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="130"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="682"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1491"/>
            <end position="1572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="724"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="1503"/>
            <end position="1520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="1528"/>
            <end position="1539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="1548"/>
            <end position="1559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGY54492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1651" mass="181713" checksum="22DD397A62D81663" modified="2018-09-12" version="1">MLFWKQQLGIGTEELQGFYAQIVDILGEERGKALLSMVLHVDDFAIKTVLMEQLPEKYTFAFREEKDVDLFLEKVRTAYNEDVIMNGANDKEQTEAPASALAAARQEADPGQAPPCNSNCACGQQPHTFATAGQPRGHAGPTRNSYRSGGHGRTGTRVGAKTRAEHYANSNKWGKIVDGKFMCANNQCVNCFGFGHRRAACDSRNPTGDRIAFLQSLDINVPVASHETYFVEDPVPMSLANHMGASFHFTNYAAEVREQTIFRAATAEAPELIFDTGATTSLVNDKCMLSDYATLDCPIFMIDAAGTRTPAVGRGTLTAEFTLADGTTSKMTIADVLHVPNFVVNLISGPSLCKQGVRIEMEEGRCEFSKYGQTFAIAQLVGSKYIFQARLSNLNPTEAQSLTVSMERKETVMGLNIKGEDFDVAKCHGCMQGRGVHANISRGPASRANKPLHAIHADLWGPVRHESFAGEVMVLGLVDDYSRFRWSFPIGKKSSVTALVVEFIQRVERSRDCNVAIFHSDNGGEFVNNSLKAFFWERGIEHRTTVPYAHYQNGVIERGWCTMFETVRIWLLVSGLPLSFWAFAATAFTYVSNRRPTAALPGSTPFEMYHLRKPNVSRFRVWGCVAYVRIAPERRASKIEPPRVKARFIGYAEQGWMFWRPDTNTVFVSDDANFDESSFKLHRGNSDDADLREDSPTTLFGDPPTGSLNIDGDDAAPGTDDRATAPIAARRAFAPDGDSRDNTPPVGRARAPDREYTPAAPGCERAPGNRVQHSNGQELTPIVPTRRAPAPVVSNGRAPAPVAPNGRAPAPVVPNGRAPAPVAGDGGAPPPVASRRPSPFLDNDADNDPPDPNPIPDGYEPVVPTTERTSELAERWGAPAGSRRRGGAEQQAMFVDLGTILGDIIPLNKLPEWEQVLSVVVNLEECNGWTNLSSIVQGSTEGICGIEELEAYQVWTGSPDEPTYKQAMAGKDHEDWSISLMTEYLILNGMNTWDKEATDPPPGVRAIPTKVVLVRKRNDKGDIIKYKAGIVARGDLQNHHGETFSPTARIASIRMINVIAHVKGYRWLQFDVNSAYLHGHITKPLWIKLPDGSTHRLRKSLYGLKQSGREWNKVLHAALVDRGFKRMEEDFGVYQRVRNIGGVDRTTLLAIYVDDGLLAGDDDLEGFLSEFDQQFKLKRGEVELFLGMKIATDDASGIMTIDQCHQIETILNNHGFANASAVATPTSDSDQHSDGGTAHLKLNYRQVVGELLWVSGCTRPDISYAVTQLSRHCADPKPEHFRQMRRVLRYLRGTINRRLEYNRHLGIDVTLYCDSDHAAEKSGRRSISGYTVIMAGAAITWASKRQVSVATSSVQAKYQALSAAARETLWICSLLFSLGFPPSSPTIIHGDSTGAIALADHPTSHATTKHIATHYHFTQELVSNGIIELRWIGTKEMVADGFTKGLSRAPHESFVRMLGMFRSPVRLESDLVPFTFFLTTSSSLVPQRYGLRSSGPAVVEPSNPLTSPDRSRQADPTTIARTLPAPAQPSTPTHAQPSHASPAALAQSPRTMSTPTAPSHSPAYKPNDPPQLHSTLMEALREYFMRLDFYNRRIARTPITSDYDKIEGAGMGLQVFALKTWFTQGLSKHLAKPYAQFKLELICRAVPADFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P889</accession>
    <name>A0A2X0P889_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g04051 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g04051</name>
        <name evidence="2" type="ORF">BQ5605_C006G04051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY55606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P889"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY55606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="82" mass="9141" checksum="46937A86C76490AB" modified="2018-09-12" version="1">MGSVLSSSATVQTQQHHISASSIAEDGRSTTLASRPTTSNSSNSMSHRIEEVQDEIEPSTMPFERCLRLRACHCRKRRPTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P8V3</accession>
    <name>A0A2X0P8V3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g04292 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g04292</name>
        <name evidence="1" type="ORF">BQ5605_C006G04292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY57641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P8V3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY57641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="402" mass="46115" checksum="35B77A7114D705F4" modified="2018-09-12" version="1">MRNVMFKLELINRDIAACREDLACVNTIDTNKLIEQSTQLQQLAKQRQVLDDRLNSLRTSDINISVLDPGTSLPSSILTLWCDPRCPRLNISIPLIGTDYEFACTLIIASRSLWDLVVQYRQGAEKLRLPCLGGKALGRKSMVRVFCAGRRNADYAAILANSEDSHSILRTRRVPPSAPEDLNELLKLDILAPLWNNGLYSHPTEPWAYDDDVRVGIPAVLSRARCQQEIKRLGWEVRRIGRWLISRRKRFQQVRQQSLQRDEQDDSAMMMLEQEEERLRNIARRWFSKGGLDHLWECTRQTGEPQVEEWVELRMWCTDDVDVFQRTTAGGLPDHTWPDCINDGMVGESDDITTDHDTLLDISDHSSDDLSHHSVDTTDYGAFSDEINENFDEDDGDVFWGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PA54</accession>
    <name>A0A2X0PA54_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Iron-sulfur clusters transporter ATM1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Iron-sulfur clusters transporter atm1, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">BQ5605_C037g11574</name>
        <name evidence="17" type="ORF">BQ5605_C037G11574</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000062">
        <property type="protein sequence ID" value="SGY93138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PA54"/>
    <dbReference type="STRING" id="796604.A0A2X0PA54"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18582">
        <property type="entry name" value="ABC_6TM_ATM1_ABCB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03253">
        <property type="entry name" value="ABCC_ATM1_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000604">
        <property type="entry name" value="ABC transporter B family member 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF402">
        <property type="entry name" value="IRON-SULFUR CLUSTERS TRANSPORTER ABCB7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="309"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="16">
        <location>
            <begin position="190"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="548"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="78"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="SGY93138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="820" mass="90242" checksum="6C45ECDC2CD5F24B" modified="2018-09-12" version="1">MAAAVVRSSTRAIATSNFTRPCHCWLNLTRSTAPNVHQSASYSTHSPSSRASPSLSIDHLRRRPPHLTRACAWVRSHAHMARSGQPDDYDSAAKKATQQHSGPEGHQKEESSKGAPSTTPTARISNASETTATSVSPVPPAKSDQSNTTDVGKTTEISDKEQSRRDWEIIKKLVPNVWPKNDWSTKTRVLLALGLLVGGKLLNIQVPFFFKSIIDTLNVEIDPTTGGGAFAIAGTVIIGYGLARIGAGVFSELRNAVFANVAQGAIRRVARGVFTHLLNLDVQFHLTRQTGGLTRAIDRGTKWVSGRGISFLLSSIVFHVVPTALEISMVCGILVSRSPHLRRSQFQELTRSVHPIPFQSYKFGWDFAAVTLATMGAYTWFTIKTTSWRTKFRKQANAADNRAATMSVDSLINYEAVKHFNNEKFEIAQYDQAMKDYTKASVKISTSLAALNIGQNVIFSSALTAMMYLASKGIVNGAMTVGDLVMINQLVFQLSLPLNFLAHRLRLTLAGTVYRELRQSLIDMDTLFSLQSDSPTAKPLSLHEGGRIEFRNVSFGYHPSRPIFRDISFSIPAGKKVAIVGPSGSGKSTVFRLLFRFYEPSSGQILIDGQPLDQVTLESLRKEIGVVPQDTPLFHSDILHNVRYGRLDATDEEVHEAGRLARVSETVESMPEKWKTKVGERGLMISGGEKQRLAVARLLLKDPRILFFDEAVSALHEAGEGFSVAEFHLLSQTSALDSTTEAALMQNINQTLLSKARTSVFVAHRLKTVADSDLIIVLQDGYVAEQGTHAQLMAKEDGVYRGMWEQQNSMEGYEGEKKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PB52</accession>
    <name>A0A2X0PB52_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C004g02785 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C004g02785</name>
        <name evidence="8" type="ORF">BQ5605_C004G02785</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY67542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PB52"/>
    <dbReference type="STRING" id="796604.A0A2X0PB52"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="7">
        <location>
            <begin position="21"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="190"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="270"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="506"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="549"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="270"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="306"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="334"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="374"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="392"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="436"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="512"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="549"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="597"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="634"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="650"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY67542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="704" mass="74932" checksum="C489ECD34F9FE5F9" modified="2018-09-12" version="1">MEVALKTNNNAVKSTRRRRRAMVNDPDTDDFISWSKDGDSFLVPSADRFAKEVLPRFFKHSNFGSFVRQCNILQQGVLKGDDEGQELLEFSNPNFLQAQPDLLCFIRRQKSRNETGAEAGALDLPALLTDLASIRKHQTAISADLKDLQQSNHALWQEAIQSRERHARQQETLNKILRFLATVFGGQVAGAEQEESPPGGSGVVLEEETGQEGDGSTNGASGGKSKGEGAAKACAVVPKMRSQLLLEDVVGRPDDRAKRLRTLSARIRDEADDEDGCGDDAEIEEIPSSRASDELPTISSAPRMPPTASTSRAPTSSQALVYPGNSPDAYRFTTVPTPDSNGLNVTSATGDSPAPDYHLSQDAIDNMFEGGGSTSSANQDALVSFLQSRSQSSATPTSGAGTSNTLFPGAIDMPSFPRTPGGNNIDFSRALMPSSPGVTAPTSNPLDALTSETGALFSHSDLSPDYRSAIRDSTQAIQDVTNEKADIDARTSALEAAIARLMQNLPEETRDQLSQQTGQGLDELSTSGPGAWSSGANGDLDLDKFLAQYDTNPTSGQTPIDYSMYFDPEGSAGSPGLGGLGNLRSSGPQFQTGLPSYDDEDHEEEEEDEEEEEEIKGNAANAASASDGIVEVTADDKPGTRETTPKPRAGSKAPSVPPKKATTTAKAMKTTGANAAIKKRKSEVVDEVEVATPGGSRKSARSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PE31</accession>
    <name>A0A2X0PE31_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BQ5605_C021g09291 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C021g09291</name>
        <name evidence="11" type="ORF">BQ5605_C021G09291</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M43B family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000083">
        <property type="protein sequence ID" value="SGZ20653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PE31"/>
    <dbReference type="STRING" id="796604.A0A2X0PE31"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04275">
        <property type="entry name" value="ZnMc_pappalysin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008754">
        <property type="entry name" value="Peptidase_M43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47466">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47466:SF1">
        <property type="entry name" value="METALLOPROTEASE MEP1 (AFU_ORTHOLOGUE AFUA_1G07730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05572">
        <property type="entry name" value="Peptidase_M43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015899880" evidence="9">
        <location>
            <begin position="19"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M43 pregnancy-associated plasma-A" evidence="10">
        <location>
            <begin position="186"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGZ20653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="310" mass="31948" checksum="89485FABCBD0CAB0" modified="2018-09-12" version="1">MRSFSFLAAAALVVSVAAAPNTGSSSQLKPVSDPRVCGTTKTPDAAAEKVIAAKVAALEARIASARGSGSATSRQAAIAAVVATKNVPVYFHVIQNAAGTSTRNGYISAATINSQISVLNQGFANSGVSFTLAGSDYTVNKDWFTNAGPSTSQQTAMKNALRKGTAATLNLYSVGFVAGSGQGLLGYATFPESYRGAPEDDGVVFLYSSVPGGATENYNKGKTVTHEVGHWVGLYHTFQGGCTGSGDFVADTPAEASPASGCPTGRDTCSSAGLDPVTNYMDYSYDSCMDNFTSGQSTRLISQLETYRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PEM6</accession>
    <name>A0A2X0PEM6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C022g09522 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C022g09522</name>
        <name evidence="10" type="ORF">BQ5605_C022G09522</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PEM6"/>
    <dbReference type="STRING" id="796604.A0A2X0PEM6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
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            <begin position="128"/>
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            <end position="533"/>
        </location>
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            <dbReference type="ARBA" id="ARBA00004167"/>
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        <source>
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            <dbReference type="PROSITE" id="PS50002"/>
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        <source>
            <dbReference type="EMBL" id="SGZ22675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="549" mass="57477" checksum="24370A16E39B884D" modified="2018-09-12" version="1">MQHAQIPEAHVMKRLVKRQRADATTTRARAAATTTRRRRGTTAAADTTRSRAAAAATTEAATTSARVATTGANAASSRSAAAVVTTRSAAAPNATKTAGTSLGSTSTASSGAAATTSPVASTSTMSHVGLIVGVAVAGIAALAVVFGLIFFYRRRRNNRSNAGASVFSNDNNHGFKKHVNDDNELFGNSAESAEKNGFAGGFGAPKNTSKLHDDGRGSWDAPSYSSHGNSNPHSNGYNAHLQQHQQPTNMGHHAPSTMNLLDDHKRVEQREMQQHLEMQQKQPEHAFAVSPQVAAAAAAAKPSANPFGGEQQGQGAVHIVKRTFEPTLSDELVLLPGDSVQLLVRYDDGWALGINLDAKGPPGKGVFPFDCLGEVTSAASQSGPQQLHTIAEGSPETSFADDSNHNKNKNNNNQHESQTDLSYGAAAPSNASSSKLAASAPQLPNLARSDSPMTFPSSQGPSTNQVPLIQISDAQNGTMSSFLDTTSTERRMSTSSLPTSLQPGGQSPEANREDGSNRSGEKGRRTSSLVASRDADLFLALGEVLDRTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PFA2</accession>
    <name>A0A2X0PFA2_9BASI</name>
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        <submittedName>
            <fullName evidence="4">BQ5605_C024g09786 protein</fullName>
        </submittedName>
    </protein>
    <gene>
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        <name evidence="4" type="ORF">BQ5605_C024G09786</name>
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    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
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                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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        </source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
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    </evidence>
    <sequence length="380" mass="41999" checksum="D4ACE64E83416CF0" modified="2018-09-12" version="1">MLPSVLRRPFRIPGSTTSFLTRMLSSSSASSPTPLLVTPSQVRELLSKRSRDQVVVLDASWHMPNLDPPRNAYDEFRNKRIAGATFWDHDIISTKSDPPVPHNLPSPSLFADACSRLALSPSQHLIFYDTYGVFSSPRALYTFKAFGHNKVSIMEGGLPRWIAEKNPVVSTPPKPINVHEQHDDREASWGPIMSELLYRKRPQVESYFIADIEEHFTEYPEPQLDTSVARDNVEIVANADKGDPSASANVDYVLDARPAGRYHGTDPEPRAGLSSGHIPHSLSLPFGTLLSPKSSTDPYYQTYLPAEELEAKFQEALGKEGWESVKNGERSLVTSCGSGMTAAVVWLGLKIVTEGKARGAVYDESWTGYAAREGAKIEKS</sequence>
</entry>
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    <accession>A0A2X0PGU0</accession>
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        <submittedName>
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        </submittedName>
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    </gene>
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        </lineage>
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                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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            <begin position="125"/>
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        </location>
    </feature>
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            <begin position="153"/>
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        </location>
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        </location>
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    </feature>
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            <begin position="606"/>
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        </location>
    </feature>
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            <begin position="631"/>
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    </feature>
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        </location>
    </feature>
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        </source>
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            <dbReference type="EMBL" id="SGY98099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="836" mass="88276" checksum="A324AEA128B5CCF9" modified="2018-09-12" version="1">MATPSGDEPPVVLQSLPLTSHPAAARSRSGSPSSSTGAPSAASSAPTTAPTTAPTTAPTTAPTTAPTTAPTTAPAATEATAATAATEATEATEATEATEATEATEATEATEATEATAVHEAVESPPEEGEEAEDGEDTSDKMVVDQDCTPARPARPPTPPPTKTTTTTTAVTTTSTAPSTKPELPIKAFVSSRYKEQLARSASRPSPSAPSTSTSSSSRFAPSPAAAPASRFVDRDRESDRERERERERERERERDRDRFDDFRRSRPPPSIMDDHPRDRWAAHRGPPPLAPSRTTSPSPDRLRIRSRSRSPLPSLRRAPPSSSRGAAYHEDDPRDRFDRGGPPPSIGADYRNRRPRSRSPPPPGESSGQLQASFTGCSSQIGATPQATAEGLVPPTMEEGHPHLPQEAHLVPPSSAEDLHLVPTHLHHQREVGRRVVVLHLLRVLVGKDPLLVDTSHPRLPLPRRPHFVGGVLLRLLYLTAEVAEVELDRLPLPSFGVTHQRRSHDALRDRHQGVHARTVETRYHHIPQQQRGPEGDHVILLRHLGEDPNQDRDRHDVVLRRHPLVQEDRAHRDDRTPAPPTGPRALAGGAIPTGPRAKVALSFNTSSSSNATPTTPAGPPTGPRALSGSVRSTFHSTPQLTPAAAAAAAAGGATSGAKATATATPTGPRPATTIPTGPRGWRSAPAPPAPAPSSSSSSALASSSSAVATGTDSSTASGSSSDLTKSAPPPPAFDPSISRYIVHPSSNLVAKLKTLASVPGSLEIEAEILKLRSARNSLGSVESTEEKYRRERWIMEDCQVEMRCAKERTRWSGGEAMGLGLGGGGMGGAGSGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PLC3</accession>
    <name>A0A2X0PLC3_9BASI</name>
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        <submittedName>
            <fullName evidence="3">BQ5605_C022g09526 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C022g09526</name>
        <name evidence="3" type="ORF">BQ5605_C022G09526</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
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            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PLC3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ22692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="518" mass="57211" checksum="E673092E4E2065F6" modified="2018-09-12" version="1">MDSIPVIVKLLNQTMGPEDSQEWLRRYGTPILDALFEGREPYQIAIEAIRDAIYPKKGPAFVTQLWTLVGLFSVSVVLTLLGIVLRLRQGRFWLFHRIDCRITMPNISVHNSFWAFVYHCLSIVELVITSKIVSGSSYPSWYISFQCALPLALFAGQVTEVWATFGSSYIRKFGSHHDDSLITSILYQSLPSMFALVTLVPSFALLAMLERYLDAVFINADATSTSLGNLSLTWVPGQALLLSNLEQSLQSIVPLIASMRGLTQWHKIATSYIGCVLCITSVLYISAAVIEITHLRKQARDLRQRVGVPVAPVSPRKLEDDSQASPTVPATADVDLRNHLMWTQIDFAQASLVEWATTNRLLVSTLISVMLLSNTFLSFRTAITHISLTSNTGDIQALALIAAWINSVLSFLVATLILFRSLEGSNALTNWLRRSAPYLPIPPTTTTTTTTRTTNVMTSYIQKPLMGVSIDVSTSVMVSNAKSDESHSEKMPAMMPQENRKGTLGSASGSSMDEVEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PLR6</accession>
    <name>A0A2X0PLR6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C025g10052</name>
        <name evidence="8" type="ORF">BQ5605_C025G10052</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EMBL" id="FQNC01000087">
        <property type="protein sequence ID" value="SGZ27094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PLR6"/>
    <dbReference type="STRING" id="796604.A0A2X0PLR6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="7">
        <location>
            <begin position="109"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGZ27094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="329" mass="37031" checksum="55F2A57A9198EC96" modified="2018-09-12" version="1">MPLDLDGAIATLLRKRLLAESLVKEICEKTKELLMRESNVVHVQAPVTVVGDIHGQFYDLIEIFRIGGYSPHTNYLFLGDYVDRGLFSVETISLLTCLKLRYPNRVQLIRGNHESRAVTQTYGFYSECVRKYGSPAVWTYFTDMFDFLTLSVVIDDRIFCVHGGLSPSVHTLDQIKIIDRFREIPHEGPMADLVWSDPDPDKEEFSISPRGAGYTFGSSVVKSFLHTNSMNHILRAHQLCMEGFSVLYDDRLSTVWSAPNYCYRCGNMASILEVGPGGEKHFNVFDAAPENERDGPGQQQQVQQQKQTGMVGDGVMASIGGPNQIEYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PPS6</accession>
    <name>A0A2X0PPS6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="22">BQ5605_C044g12139 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">BQ5605_C044g12139</name>
        <name evidence="22" type="ORF">BQ5605_C044G12139</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000114">
        <property type="protein sequence ID" value="SGZ31312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0229">DNA integration</keyword>
    <keyword evidence="15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="12" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="16" id="KW-0862">Zinc</keyword>
    <keyword evidence="16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="20">
        <location>
            <begin position="422"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="21">
        <location>
            <begin position="1613"/>
            <end position="1785"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="19">
        <location>
            <begin position="1928"/>
            <end position="1989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="459"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1292"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1364"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="42"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="459"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="484"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="512"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1372"/>
            <end position="1384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="SGZ31312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1991" mass="221067" checksum="2BC334423D54D39A" modified="2018-09-12" version="1">MAEPTDTSRDTTAPVREDPSRANPPKSPPTHSPHPLQAAAVITSLESRLAESEALRRDSETRIRKLEQMVERLMRESTAPAGAQVGEALPVRPVPLDVPPHTFLGRPGAAADPLARTPGGESHSGIRDGPSSAVISSRWRGTLPDREGLWTGDHPERLVNFTAFGESYLSLLCDISTSDLFDTSRVIQLVATLFSRTTTRQRRQSPLDWAVEAMRDALGEGRPHCWTSLMKAVGRRWPDPGFADRVAQDFHGCRQSSSRAYDHVGEWRARYRAFVHDNDSFTLSPLQLATTFYQSLSDSSKREVRAGMLREYHDNSLVTIGRFGLKVPSIDEITEWAAIADDISPPPSVPTPPSRTATYGAIVKAPRVSPPATNTPTVDERFQIRRARWVDRATKWQQSHSWKDRSTWFSPAPSGVPTSMACFNCGRGGHFSQHCTAERQSPVAVQLSAVAVADLDDEDWSSVAGGDEDPEVRVPISLERVQTRPLSSVSASMTRPSCPPADPVGRMKEGASSSVDVEVSSSNPQPTAPASDADLRRLADDSTDSAFDAVEDVPSYADAASRMRRYWGPEVVSSRKAERTASVSSVRVPVPLGVSLLESDTPLIDVDDFARPAEPAIVRARNIIAWTLPSGRTLRCLVDSGSEVDLVDQDVVRTDPSFTTSRLTAPLHLRLGTRDKSDRCAVFANALFTSGSLDLGLRAFFICRVTAYDAILGLPFLKDTGMLVGWGVFTVARPGPSQPVAKGTHEWDRAVTVAPICSGSAIGYDHPGLLPDDEIIGLEPHNPLLDVVDDPALEDLSESEARTRLAALLEKYSDVFVDSLPMDRLPPYRPVNHEIPLIDPNEKGKPRVYPLADKYRSQWAEHSAKYTRGRFWVSGPIDSAAPVFAIPKKNSQTARFVIDLRARNSNTAKRFSPIPDMTSVRYEVARSRYRSKFDVAAAFEQVRVIPEHVDRTGFATVTGTYTSRVMQFGDTNAPNTLNLLTSAMFQPCLSFAKIFFDDVHVHSDTRRAHLRHIEILLMTLRHYRFYLGSNKSEWFSKSLDSLGAIISDDGIEVDPAKWERIRQWPTPHNKTDVQRFLGTVNWMRDHLPHLSITLEPITALLAQSTSWRWNEHEQQAFDTVKSLVPATLRPIDGAKVTSGEHKIYLFTDASRVGIGACLASGPTRSQAVPTRFFSAKFNGAQLNYHVTDKEFLAVVSACRAFEQHLIGYPFVIVTDHQALRTIKTQKLRQTPRHIRMCLELSRFDFEFEFIAGKNNSLADSLSRLWEVKEGSPEDQVKENELEDMFFDGERHGFTTHGESLPEERPYTSPSPDRLPPVDFAFGPQRDDCEAGSPGYYALKDESQDEDVNGRDLGKLFLKEECHEFTTPGESLPEERPYTSPSHDRLPPVDCAFGPWDHGYDAGSPGSHRLAENIMDTVDSSTGPLSPPIAVNRVQAIAAAPANDAPIPVDADADELDLLGAAADEVNDAPVVHRPPDPLPQPFLDAVIRAYAHDSQAQVIVDDPLSWPMFRVTEEGRILRVHPDESLSLFVPRGPATGVVDSDKVPSLRELVLAEIHRSVGHAGHRITLAAIRPLYWWSSMSADCAKFCHSCEDCARGKASTQVPYGRLHPMPIPSGPWEQVAIDFMTGLPPVEFEGMMVAQIMVVTDTWGKMVHLIPLPADADSELVADRYYATIFRLHGTPSAIVSDRDPKFTSQFWRALQAKVGTVLRMSTAAHPETDGSSENRIKMVTQTLRIMVSSNHEAWASRLVEAEFALNSSVAVSTSLSAFEATYGYLPRRWPTDSWSVSDVPRAEAFARIRQLRNLDVTDAIIGARLDQTHQANKHRRPDDPAFRTGGYVYLSTKNLAVPEGMKSKLLPRYIGPFRIRAAIPATSSYDLELPPAMSRVHSRFHARLLRPYVENDAERFPGRDPAVLFVEDVADAADNSAIPERIVRDRRNARGNRSFLVRWIGRKDIDDTWMSEQSLRFDHPSLLDTYLAQLDRSNRRLSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-11-27" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LS66</accession>
    <name>A0A2X0LS66_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondrial fission process protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial 18 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C012g06738</name>
        <name evidence="4" type="ORF">BQ5605_C012G06738</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MTFP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LS66"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019560">
        <property type="entry name" value="Mitochondrial_18_kDa_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001:SF2">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10558">
        <property type="entry name" value="MTP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY16031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="228" mass="24953" checksum="1EB4C9594B6C11BE" modified="2018-09-12" version="1">MTSVAKPAGSPVDTMEQQIVDGEIDTTESSARYLAYLARIRPVLQPMTRYLAYTSDVGESVRPIVNPKMVTGAYGVSWAYLVGDVAYEGYKARLRANENCPEAVSTVVGLNVAKRAIFQSVASMLFPSLTIHAIVRYTAIAVKKANVKSIAVRRWLPSALGLGFIPALPFIFDEPVEHVVEAGFDRLEARLYPDAKSGVRRALKSIEEHERHAKPKQVVIAGPEAKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LSZ0</accession>
    <name>A0A2X0LSZ0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C015g07840 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">BQ5605_C015g07855 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C015g07840</name>
        <name evidence="3" type="synonym">BQ5605_C015g07855</name>
        <name evidence="2" type="ORF">BQ5605_C015G07840</name>
        <name evidence="3" type="ORF">BQ5605_C015G07855</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LSZ0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY17631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY17682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="166" mass="18399" checksum="B79A522F207BA175" modified="2018-09-12" version="1">MSVQTPRPVRRPPASRASPTTPAPNHSTNPTTDLPAGRLVLANDARRSKLFWAKVLTTRRTYPRPVQIEVIAVLSKLDQFGNRDRYDAVFVTAPTSLGKSVIFEALYLIYGRRAVSIVVSPLYALSNHPGKKAVVVSEETWRDGELYRQLDDPNPTISFILIVCAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LT57</accession>
    <name>A0A2X0LT57_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C011g06300 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C011g06300</name>
        <name evidence="2" type="ORF">BQ5605_C011G06300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY11869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LT57"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY11869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="212" mass="22971" checksum="D2A825635F617CD4" modified="2018-09-12" version="1">MAAKIEARRADLRLIEQRAMAFGKTEARVAAEKRGPAAYLELINSHNLGLEETGQSRRFTLAVCRPLFRIRDNVPWAYSSSRASTTRHPAPAAPLPDPAFSRSTSSDARTTRSSPVHANDRNGGGGLLTPAARSARGRLSGAQLGLKKSASHAPSPSPAEAMQLMPTSKEESRKGKGVQRFESGEQAEEDEDWGKSASVNLPGRRRRQSERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LV88</accession>
    <name>A0A2X0LV88_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C017g08550 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C017g08550</name>
        <name evidence="7" type="ORF">BQ5605_C017G08550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY20249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LV88"/>
    <dbReference type="STRING" id="796604.A0A2X0LV88"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049680">
        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 49 MEMBER A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="488"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY20249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="543" mass="58140" checksum="B44B16005A73B173" modified="2018-09-12" version="1">MSSTAPGLAGTIAANSTTTSTREAPAHGAPPTALPLERAVNPRSPTEPTASPSSATGTPPSLISPVSIPIDNLTEDETKAEVQVFSALSSVGYRVYRQRWYGLVALTLINIVCAISIDTAAHFDVSTTRVNWLSNIVCGAYVFAAPCVPWLTMRYSIRGVTLIAAALMLIGGWLRYAATASTLSPDGAYTLLFIGSFLIGVAQCFVQVIPPAFSETWFGLNARTTVTMILAVSSPFGGAIASLLGPSVVTNPSHLPLLCLIVAIIVTVCAPLAFLVQARPPTPPTKSAEGRLMSTAEVWRGFRALFGKGDQEGRCMTRRERCDFAIISVIFTVVLAFFDAFLILINQIFEPYGYSSDQAGFIGAAVIFSGILAAGVSAPLLDRYFPFRLALTAKFLVPIIGLSFLLLIWIIKPSNLASIFVITILMGCSSFMMLPIGLEMAAEIGYPNMGIEITSAVLYWLGNGASVVASVAMNALTSGPNANPPNNMRRAIVFEGIIVFFTSFPILFIKGDQTRRLEDVRAHEEMEERKGWVALGKGFGRDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LVX5</accession>
    <name>A0A2X0LVX5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C019g08887 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C019g08887</name>
        <name evidence="2" type="ORF">BQ5605_C019G08887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY23046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LVX5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY23046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="81" mass="8744" checksum="2D36A7FA133C8791" modified="2018-09-12" version="1">MTRRDLTGWCGVGTSRTVLAVEKVKAKPDLPPALDPVERRAAGTGCSEQDFEKETTALASAVRAFFDGDRPATQERAAYSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LW18</accession>
    <name>A0A2X0LW18_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C012g06744 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C012g06744</name>
        <name evidence="3" type="ORF">BQ5605_C012G06744</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bystin family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LW18"/>
    <dbReference type="STRING" id="796604.A0A2X0LW18"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007955">
        <property type="entry name" value="Bystin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821:SF0">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05291">
        <property type="entry name" value="Bystin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY16053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="462" mass="52409" checksum="E3E565FED9A55CC4" modified="2018-09-12" version="1">MPKASTSRSSSAAKHDPLSVQMTQQSLVDSGNLSLPGKRQKSKHKNAQSEQEHAQTTLDAKVSRRVLEMARDQQDELAQEQWADELDQDLDQTAARYENDDDDDDDDRDDDDEEEDDDEEEYEQYEELEFDGNDAALDQFMPQGQLAGGRTLADLIMEKIEQQENDKTAVPVVAPEPPPGYNPKIVEVYTKVGGLLSRYKSGPLPKAFKILPTLRLWPQLVMLTVPENWTPHATLAATKIFASNLDPKQSQKFYKEILLEKVREEIQETHKLSVHTYMALKKAIYKPAAFFKGILFPLCESQTCTLREAAILGSVLTRVSVPVLHSGAALLKLADMEYTGKSSEYTMCPNSVFIRVLLDKKYALPYKVVDALVFHFIRFKRDPREMPVLWHQSFLVFVQRYKSDLTEEQKRALLDTLKVKGHPQITPEIRREILNSVARVEEAPLANGQGLETVMAMEVEIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LXQ7</accession>
    <name>A0A2X0LXQ7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C002g01106 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C002g01106</name>
        <name evidence="25" type="ORF">BQ5605_C002G01106</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY30004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="555"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="299"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="906"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGY30004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1552" mass="173557" checksum="B773E35707DA1C3D" modified="2018-09-12" version="1">MSSTTTTNVSNEGDVKITKLGASSYLYDLAPRSLPLASTCFHEFLSLSLGFPATINRASYSYKNNYINPASLDAFLEGRGYSSVLQHGADRPSSMDVQAWKTLHGIDPSLEEGKVPTLITKWDRSARAIIISCLDDSNLKMVKSKLLSAKTIWEKLKQHHEGNADPFKIRTLLYEISNASYDEDTNLGEFLQGITDKVDQLEDLGQKFKDEAIVAFMLQALPPSYEMLKQAIKLSDKCSVDYAVNQLTDEYSERKLTGKYDKLLKNAGALAVREGTQVKRDPNCICRGCKGTGHYQIDPECPKYDPNAKRGRNKNHSNKKKKQHKHSKGSADSEESASFALVVKSLEESHSLHINVANRVSQNDQSEIWILDTGASQHYVGNASLLTDHQHGSLNVQTASGQVVHCDTYGTVRFKLRSGASLSLSNVYHLPGAPVNLVSTRALYRSGASCGWEDGRDVMTIKIKGLTVAKTLNGTGYTLDFTRIVEDQAHVATRATVGAPLMEWHRRYGHIAVSSLKELVKSGAVDGLVLTDEKVHDCEPCISSKSRVSKFSESVTHVTDVLQRVFMDIGFVAEDQVDFQGRKAYLAIVDQYSTAKWTFPLKTKSAEEVTRVWITFRQGVEKMTGCKIKRVRTDNGNEFTNKLIGTDFQSQGILHETSAPYTPQQNGTVERFNGSLMAIVRAVLAASKLSWKYWLKGTRSLSSLTGNLADRCKLYGLQLASGYSPSFWCQPDGEGTEEARCARSLFLIPVARSKARALRWSYAMEYATFVANRVLHSKLDGKTVYEVFYGKKPKVSHFRPFGSTVFAQVPKSKRSKLEPTSVRGTFIGYDNEYNYRVLVDSDSEHKVVITRDIAVLNLQPEEVRAPEVTTLLEGPDEDVGPVLEGNDAGDELQDEVAVEQIAPARPNRPRWEYGDPAVRGRNPGSFEEIDAGNEIHQRTRGQRRIAEQQGLFVTDIPELDPEPPIMSGYAMISTDQPAVPSSYEEAMNNVEADKWKEAIQDELNAMDRHQVLADSDLPHGARALGSKWVFARKENAQGEVIRYKARLVAQGFAQRSGIDYNETFAPVARSTTIVFLIAIAASQGLCLEQFDYDSAFLNGTMTEMVYMKYPKGWDRPQLGQVLRLVKSMYGTKQAPREWNSAVNKLMVACGYSRSDADSCLYVKRVEEMFIYITLYVDDGLAASNDQMFLDSEIQAFNKVYQLKRLGPVKVFLGLEFLRSSKFIFVHQSKYIRSLVATYGGDHGSKHPAKVPMEPRLNMEHSAELFDDIALYQSAVGALQYAAHRARPDIVTSVRAAASKVSAPTQADWIAVKRIIRYLQGTIDWGLKYNLEGLTVFELYSDASWGDDMLTGKSIGAFVSIMAGAAISWQTKEAMWLRRLAADLKIQQPGSTLLWEDNQAVIAIAQNPAHHGRTKHYSVHHFYIRERVTTGDIRIKYCKTGAMTADLLTKPLARNLFELHRDGLGMGQRSRGTCGIGKLARAWRGARWRQMAVWRIDWTQRWLARGYYLRLWSRSLSPSSLTHTRYLSRPFACYKLIDLGDTLSHNRSSINAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LYD1</accession>
    <name>A0A2X0LYD1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C014g07512</name>
        <name evidence="14" type="ORF">BQ5605_C014G07512</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY18940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LYD1"/>
    <dbReference type="STRING" id="796604.A0A2X0LYD1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05147">
        <property type="entry name" value="RIO1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051272">
        <property type="entry name" value="RIO-type_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45723">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="13">
        <location>
            <begin position="208"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="116"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="519"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="627"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="556"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="569"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="664"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="698"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="715"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGY18940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="727" mass="80719" checksum="5A902EEE51DDCD35" modified="2018-09-12" version="1">MPLLPPDQQPHRPSPVPATEARIDSVAADSSEHVTSIALTDEGTPLEPLDIVLDQDEPVEESDDYNEEEYDDYDEDWDLETELDSGINQVMDQDWADASGDFTKRYNRLKQHVVASSASNKATGATSSAGGSSMTSNILPAINRPKRVTSSSATSSGTPGVHTDKVSDQLATLNHRFASKLDLDPILNRSANVGVTRKGGSEKVLVKDKSDRATNEQVLDPRTRLILFKMLGRGLIERVDGCVSTGKEANVYHAVSPAAGMREEGKDGEVQKEAEEEKGEGSVRFAEETSAAVTTTTTTTTTLPPNTPRHLALKIYKTSILIFKDRDRYVSGEFRFKSGYARSNPRKMVRLWAEKEMRNLRRMKNAGLNVPEPIEVRENVLVMEFMGVQEGEDEWQASPRLKDADILFSALPDLYLDTLVILRILFQKCKLVHADFSEYNVLYHRSQLVIIDVSQSVEQDHPSAFDFLRSDLKNVEEFYGRKGVGTTLGLRGSFGFVTRSFEGVGEETEEGMREEARRLLSVREGQLKREEEEESTTRANDPTSFDALKLKKTNQPTTSSPLASTSTSNRASSQKSSQVDEAVFAQSFIPRALDQVYDIERDVARVLRGEGDDLIYADLTGVARIREKEKKKAADAEGGQGVEGREGGEGDGSGSASEHSNTDGDSDDDEDEEEDEGTFRPKGKKFEDKDEKKKRRAEVKAANRDKRSQKMKKSEKARKVRKTSGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZK7</accession>
    <name>A0A2X0LZK7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C016g08224 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C016g08224</name>
        <name evidence="9" type="ORF">BQ5605_C016G08224</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY21339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LZK7"/>
    <dbReference type="STRING" id="796604.A0A2X0LZK7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
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    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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        <source>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="677" mass="72547" checksum="EB69780899191A8C" modified="2018-09-12" version="1">MPGVAVLPQAAGYGVVLGIGLFFSVLMVGLTWVQNRYTKYKATSVAEFTSASHSVKPGLIASGIVSAWTWAATLLQSSAVCYKFGISGSWWYAAGATVQVLLFAQNSAKLKTNAPNASTFLEVIRTRWGTLGHATFGFFALCCNILVSSMLITGGSATVTDLTGMSTHAACMLIPVGVVIYVLIGGLRSSLLADYLHTTFLFSIILTFMFTVYTSKSAGIGSPKALYERLTEIAKIHPVKDNAQGSYLTMRSKSGTTRLHPPFFAQNLSTETVYCDQAYWQRAIASEPASCVKAFILGGTAWTSIPLGFATTMGLAAVYFQVDLTPGEVSAGLPAAAAAVQLLGKTGAILMLILLFLAVTSAASAELVAVSSLFTYDVYIPYINPRASDSQILKVDHIAIVAYGVIMGLLGIIFFEAGISMGWLYEFMGCLIGSAVAPIALAIMSAKANRLGCIAAAWIGLAVGIAGWLGVAAAENNGKITIDTTFQDYPMLTGNLLALGVSCIIAFSTSWLWPENFDWEITRAIHSERDHSETAPVKNVDVVEAEDSDKKETEAESPKVASARASLSEELGGLAYNENKHPAKLRQAFKLAVYVSVFLFFLLIIAIPLPLFFSSYVFPQVGFTVWIAITFIWVFYGSFAVVIYPIYESHGSIVEIGKAICADVTGKRFKDVAPSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M035</accession>
    <name>A0A2X0M035_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C019g08925 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C019g08925</name>
        <name evidence="3" type="ORF">BQ5605_C019G08925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
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        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY23309.1"/>
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    </dbReference>
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    </dbReference>
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            <end position="49"/>
        </location>
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            <dbReference type="PROSITE" id="PS00036"/>
        </source>
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            <dbReference type="EMBL" id="SGY23309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="547" mass="61132" checksum="2151A3E3FB12027C" modified="2018-09-12" version="1">MSQDHEHETEDEEHRGDGGKGKGKKTTKSKESAQRKQQNRLAQREFRQRKQAYVKELEVRVNLLARSKDDQLEGMKLTIRTLLDENQELREVLGHLGRFIGSGLGGCLPEIGLSPEELKRLATRGRLDAVHKIMEQMDRKDSKDQDPWARKRSSSQNGRAESSHANAAHGTSGQTTATTSGSGDVTESDKSKGKKRARTLDSISSLPSQPAEVDAMNDLNGYFAIDPTTTMAPWSQGLQDEPNGSLGDVSLVPSNGQRITPQQIVRRERQLPEGYPPAPATTTSTTSAFGIGGMSNQNATDLGASSSSVTGASSISPDPLYHHNTHESTSTLEDVRSEMRQQHEEANAVIRDLIVSFNFSNEFWTSTDEDGVKMFAEFIMNLLSHPTDNSKLQALQLIACKSSPKGPFPPPRHTHQASDFFFASDHVRNKLENASYHLPSALRATEIQQSIPHPPWIDGIIFSSLRDRVILLPKGRCDLSVLWSDIMDHVECHENSDCLSPANWEISQHFMKKYWYLIDENVLSISNRWRMERGERMLEMKDLVPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M0R6</accession>
    <name>A0A2X0M0R6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C019g08914 protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="primary">BQ5605_C019g08914</name>
        <name evidence="2" type="ORF">BQ5605_C019G08914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
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        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY23210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY23210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="98" mass="11187" checksum="CAAC8508D8EEEF14" modified="2018-09-12" version="1">MVITASTSTTRSTSQLSTSTGLTTPGDGIYLYFEWRNGLKFYWFSGTEYDEFFNGSERDDDDDDDDDDDDDDEWISTDYGHDGKYVFGESGQGFQFEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M176</accession>
    <name>A0A2X0M176_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">shikimate kinase</fullName>
            <ecNumber evidence="2">2.7.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C003g02308</name>
        <name evidence="11" type="ORF">BQ5605_C003G02308</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>shikimate + ATP = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
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    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY40001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M176"/>
    <dbReference type="STRING" id="796604.A0A2X0M176"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00464">
        <property type="entry name" value="SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00109">
        <property type="entry name" value="Shikimate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000623">
        <property type="entry name" value="Shikimate_kinase/TSH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023000">
        <property type="entry name" value="Shikimate_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090">
        <property type="entry name" value="AROM/DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090:SF5">
        <property type="entry name" value="PENTAFUNCTIONAL AROM POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01100">
        <property type="entry name" value="SHIKIMTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01128">
        <property type="entry name" value="SHIKIMATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="263"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY40001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="367" mass="40133" checksum="3CCF81B7FEB15EC5" modified="2018-09-12" version="1">MPHAPLYNADATIALVGMRGVGKTTLGLIAATSLRRQFIDADSAFQTLHGPITDFVKARGWADFRDKETAILKQLLHQYPRDYVIACGGGVVEREENRSALRQFRASGHPIVHVVRDKEETIRPSWGEEIRAVWSRRTPYFEDLCSHTIVSLTAYPPPLSPQFLMKHVETAFVRLLRSIFGLASSHVPLIPGPRPSPIAGPSSGEYGGYGACESEMGRGAKGQRTSFVALNFPNLLNVSGETIRKVAGGVDVIELRVDTLRQSLPKTPPDSRGVSPSPETLHKARSNGKGGTKVPSPHFVTLCFGHLRRCSPLPILYTVRTRSQGGEFPDLETEELMEGYLALVELGFRLGAEYVDLELGGNGVPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M246</accession>
    <name>A0A2X0M246_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C001g00053 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C001g00053</name>
        <name evidence="1" type="ORF">BQ5605_C001G00053</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY43737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M246"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY43737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="920" mass="103430" checksum="2DC5F4768C358D99" modified="2018-09-12" version="1">MRLPRLRLISPSLVPKVTQRLQSRTLPPHDLAKLQLYLFKRDHSLSRDAWTDLLTLLRTYTFHNADLSDMSEYKMVRTIRHLTGFRTVEVGKCPKGCVSYGAKRFEDLEECPTPGCRENRFTLGKNGEKIARSTQRFYDPAPFVEALRAHPVIGPTLANAKPSDDVVDLHKASGGSGSYPVVRRWVDGLHARTLYANGDLKPDDIPLATFSDGTEVLAHSNANRKVNAHISGVIPMTLPPELRWKLSSHFVISVHGPQKPKDEQSFLETFCEQLHIFEGERPSFSAARDRHVLCRDRIVACIADTLEQAALGNLVGARGLASCLICSIISIPHYAPGNTKGYLPVCVPHAKVFENDEGVIVSVLDHPEWAGLVNTATTFQTPGGRDVRLYNERNYKHYRRVVKAMKRHPTKLESLRRRTGISGEAPIEALDLFKDAYSTFLPLDYMHLIGINSGSTFINILVGDLDSKAREHSMMLSSDAIARMTRAQLLSRPYLARVEGVIVRPLAEKREKLESNRTGTQLTALTIRMFAAMKTDVFIDDSVDFFDHLPDVDRLEQLRLYELDEKGEVPITYTYLYVLIEQTLLLREKLLYDRDPEFLHLFPATNHRLMHVPDVMKRMGPLREYSACGTETMMGYIKGGRRSKSKPVESGMISAEMRNMMMILRLKYDIPTMDDLRDTLPRDHALHAQLPGYKLHTLKKTTQRPSQNFVDLTEEVAVFHGGSVTSITLWGRMQTTTPRTLYAMDFGSSLDEGWRRLEGAGASAVTLLGSGNELRNTQGTINCKTARFVQRFFTANLGSTDVNGGRQFTARGEVVRFVELGITTLKEKRLLSLVDVFPVAMDIRGLYERFDVDGPRTLSLIGVERLRQLVSIIPNTMRSPPTAAELARGARPAVTAPDTYAISVFPHSTATPLRRVDAWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M3T0</accession>
    <name>A0A2X0M3T0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C002g01771 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C002g01771</name>
        <name evidence="6" type="ORF">BQ5605_C002G01771</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruD family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY35491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M3T0"/>
    <dbReference type="STRING" id="796604.A0A2X0M3T0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02576">
        <property type="entry name" value="PseudoU_synth_ScPUS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.20">
        <property type="entry name" value="TruD, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020119">
        <property type="entry name" value="PsdUridine_synth_TruD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011760">
        <property type="entry name" value="PsdUridine_synth_TruD_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326:SF21">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE PUS7L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01142">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037016">
        <property type="entry name" value="Pseudouridin_synth_euk_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50984">
        <property type="entry name" value="TRUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01268">
        <property type="entry name" value="UPF0024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TRUD" evidence="5">
        <location>
            <begin position="401"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY35491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="814" mass="89002" checksum="E70D2F041F254CE0" modified="2018-09-12" version="1">MSSPEPSAKRLKVDAPSMSTTTATTDSVTEPAPAARSTSTPFSFANEKGLLKLIEPSLGIRPALESEVGITEYVDRDVPPFAAIIKHRFTDFMVFEVGLDGQVLRMKDIHGPKQEKAPKPPKPETPKVEPTPEDPQQLWTDKAESIITPLLDEAKLVEFKTFVLAGPSAPPGTPKPVFQSQIIESKEARTALHKGLREAFDSRFGSEMKELEGGQQVIQVTWMKKGGGGRGGGGGGDRRDRIARTAEGDLKVKLPPYIHFTLQKANKEMHDALSGLCRTLNLQSRDIGAAGTKDKRAVTVQRLSMKRGHRTIEDVWNAANGRGARGGNRGRGRGRGGGGFGGSHAWGNMDRGVRIADVAYGENMFTLGMLKGNRFVITLRDVVADSPTTIERAMSTLREHGFINYYGMQRFGTAPVPTHAIGLALLRTDWALASHLILLHRQGEGDDVALARSLFHEGKLVDASREMPRRAVAEKAMVDFYAKNGTTSHLGALSSIPKSLRMMYAHAWQSYIWNRVVSERVKMYGCKEPVTGDFVLAEGAKLKEDGEEPDEPEVVVAEPLDPVLDEDDEPIPANTGLTAEQAAATARVPKIKILTQEDLDAKTYTIFDVVLPMPGYAVTYPSGSLGETYRSIMLEDGIDPKNMFRRQREYSLGGTYRKIMHLPRDVSHRLMTYSSSTQDLAQSDEDVLLGKEAPVVTAYDPSQPMPEGHSLALQLEMTLGSSTCGWFQSNRTRCCEGELTLYARCMLPPDATMALREVLKTRTASAHQKTLTEAMEQREQKVSESTAATSALAAQAEEVVPEAVAAVEDVAMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M3Y8</accession>
    <name>A0A2X0M3Y8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="26">BQ5605_C003g01994 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">BQ5605_C003g01994</name>
        <name evidence="26" type="ORF">BQ5605_C003G01994</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY38301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M3Y8"/>
    <dbReference type="STRING" id="796604.A0A2X0M3Y8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <keyword evidence="22" id="KW-0862">Zinc</keyword>
    <keyword evidence="22" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="296"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="25">
        <location>
            <begin position="545"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
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            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="SGY38301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="693" mass="75628" checksum="ECBAD3465E9D7523" modified="2018-09-12" version="1">MDSSPASPLAPRDPSSPESSIGEQIATLQAQLAALQALQPAAAAAAATPAVTAVPGNAATASKVVFPKHARLDGPKSFTNWLRQLRLALPNQVRGYVLDGVIPPTWTANQLAARDDAAREIIVGSIDSTDVSATLDAIPSDDLSAPRIFAALKARFAPDDATRTLELFARLWDFRKMPASVEAYDTWLREYMSIAQEIRDAKTSLNDVLATHVLAMVPSCLDSFRLTFTDEQRNRRDLPELTTLTDRIRIQLRSAGLSTSHSAMLATSSPCPACRAPGHRLRDCTSRAKHPPTGPCRRCHKKGHWALDCKNRGEQARSSDDTQDDTSSSAALQPNVGYFASCLFARRQLPTDAFVVDSGATTHMVADRSLFTTYRQTAHTKIGGIAGGITAIGMGDVAFVAKTGHPITLRGVLHTPGLHVNLLSVARLCDTDRVRLAFTSDGIDIAKDGQAIAHGTRVNDGLYLLDVDHTKCQHLAFLSRSESPVPLLTLHRCLGHLAPSSIQKMIAAGLLHGFGAGYSDKDVEEFVCNACLGSKGHRLPFPDSESHSPERLGLVHSDVLSFPTPSLTGKRYLVTFLDDHSRKLWAYAIDHKSDVFTIFQTWLAEVELETNARLRILRTDNGGEYRSNAFTEFCKSKGIRCQYSIPYTPQQNGRAERVNLSIVEGVLALLADARLPATFWDEAVMLSRLLKRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M679</accession>
    <name>A0A2X0M679_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g04186 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g04186</name>
        <name evidence="2" type="ORF">BQ5605_C006G04186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY56873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M679"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046496">
        <property type="entry name" value="DUF6589"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20231">
        <property type="entry name" value="DUF6589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6589" evidence="1">
        <location>
            <begin position="4"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY56873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="234" mass="26426" checksum="525E4BFC10781EE2" modified="2018-09-12" version="1">MYRALARLVPHLGLTLHDPRCTPEPIEQLDVRKPDITLFQMMDESDTSTADVAKVIGRLRMQLGLSEKEYTDSLRILECDGGTSMLVESLRRNRFPFRRLYDGLGTTITVPGVAHLQWCIGAAIYRRYFEDPLEGSKYRGSLFITANLLDRKGLDPQKIKDYNQMERLLRGTAQLELLSCVDVCTGMMDYEGGSDVVDWRCGPKVRPVRRGWLIHVGAKNGPSGSVREPAPSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M798</accession>
    <name>A0A2X0M798_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C001g00418 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C001g00418</name>
        <name evidence="3" type="ORF">BQ5605_C001G00418</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY46352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M798"/>
    <dbReference type="STRING" id="796604.A0A2X0M798"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF1">
        <property type="entry name" value="CHITIN SYNTHASE REGULATOR SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="275"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="891"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="897"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="946"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1041"/>
            <end position="1052"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY46352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1062" mass="113080" checksum="31634AA92308BD61" modified="2018-09-12" version="1">MASPVAGASPSSPQSFRVSSSPLLSEAGAASRPFTLNGGATPSTASPFAAGYASTGGLSVLNRPRPGQGGRKSVELSHHHASTLSMSSSVSSSNQPSTDSERERAQQHHSPSAPSRPNVLGHPASAHAPQHRMTHHSNSESEETEDEMSGRHGRQTTARRNSFFGIAANARDRDEDDVEVEARTAAQMRSSSSSSYGALADREDEAASSGRPSTSSDRQLRDERRSSFYGLDGHLDPSQGLAGLPANGLSSSHDLILHTTSTNVYASSQLHVPQYHHQQHGAPGADSGSGSYSSHELRSSGGTATTSTSSGPAVVSQVGAQGTMLGQRIYSAPYAASRAASLHLQAGIGGAASIIEPSPSSHRLLSDQSHLQPGSMASLLSHEKTLDLYRANAKKNDDPDIQFELCTFTMEFVAEMEAISGADRLAPAQSGFRDASGAVTTGVSSPGAAMSNVLIKDNKENGVLGATDLTSRTKQQELVAESVTLLNKLATRGHVKSQYFLADCYTQGVGTAKGRRDYDKAFPLFMLAGKHGHSDACFRAAQCCENSWGTKKDFSKAVTLLRLVHFHPSSGGASTDESRSMTPVRSHRRAAVLNHPGAMHRLGIAELNGEMGLARRPREGVKWLKRAAELADQVDPPQPQSLHELAVLHEKGIENVIFKDEEYAAELLARASELQFAPSAYKLGECYEYGKMGCPQDAALSIHYYNIAAQQGHPEACFALTAWYLVGSPGILPQSDTEAYLWARKAAGFGLAKAEYAVGYFTEMGIGTYKDAREAIDWFRKAAGHGDKRAIDRLRMTGATVETMYGRPSPQAPELPQAAEPAGNYKPAIETKMKNRTLNRFGVGKREGLSIHTGGRSISAGQALSAVESRGQPSAQEFDDALRAMHNAGRLEFPRQRSVSQPSTPTDAYQPHPRQRHDQQFDYSGVRPGGPPTPPKTPASQQAHWGRSGSPMGRGPSSPSGPSSPSRGGPMPGRGNRPYLASLYTGGHPPSPNSRVLPPGAVQPRSSTNELEGALPIRPPSPGHASSKSKHEPNVLTKKGLNSNSTPPSLSNAAGKVFWKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M8J1</accession>
    <name>A0A2X0M8J1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g03945 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g03945</name>
        <name evidence="2" type="ORF">BQ5605_C006G03945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY54991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M8J1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY54991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="359" mass="40403" checksum="C8C3E362067D29E2" modified="2018-09-12" version="1">MHEQWAQRRLDEELEYCIRHNIRLDYLRSIVAPVTRLGSPTCWNDFVQSKYFESLAFQDGLEVPTNLVKRVKLAKPYWNDMKDDAELMTRFDAALALEREEATQVTQATESSSSIKIARNKPMSHEAIKKARRCMQAALETMSTSYAQKYGLQLFAVVSSDLPELNKERFMVASPGGLAFAYRQDWGDNLGSRQLLSDFADCVTVRAFLEEKKAELEAAVWEAPLTEANLATKASWYSTIVKKLFYDAVKRRTKNQGHENKNKPPRLVYDPTALMQQASIVVECGPSPNLETDFASPMGKPKMSGADLDRIIPLLRAGELRFRLTEEVLADAEDEDGAAIPANDQDGSAVSRPDSDEHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M925</accession>
    <name>A0A2X0M925_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C004g02870 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C004g02870</name>
        <name evidence="4" type="ORF">BQ5605_C004G02870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP7 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY68253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M925"/>
    <dbReference type="STRING" id="796604.A0A2X0M925"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040446">
        <property type="entry name" value="RRP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024326">
        <property type="entry name" value="RRP7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 7 HOMOLOG A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12923">
        <property type="entry name" value="RRP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal RNA-processing protein 7 C-terminal" evidence="3">
        <location>
            <begin position="279"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="390"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="390"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="409"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="442"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY68253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="453" mass="47309" checksum="22D2B7E0B18CE16D" modified="2018-09-12" version="1">MARLSTQPTPVAASASGSSSSKFKPVALRSGFYALPLAVASSVSSSSSKRSSTSSIAVEYIFVRAHHSFNSAQDDDEPEQAVAASTSTTLFLTGLPLGVTENALRKLFKSLYPRHKIVTVQLLPSPNAAAASNTLLARELASVSATPSIDPLFISSDAIEANSISVAQSALMTFDSTPALPPPVPSIVPSLSVPKSPNFLARARAKYDQARPHRSIVISHTDTWMQNHDQKKASLRPSSAAAAAAAATATTSASSSKKGKKAAARDPGPLPGSAAFALAQYAAQQARLASASYNPDDHTGPQDAEGWTLVSRGGRHGTSALDVEALQNATTDGYGGRAVKVASKTWLKGLEGDGATDLETGQRNIVGKGFYRFTKSDERKQELAALKDRFEQDKGRLNEFRESYRGRGGRGSRGGGGSGRGGGGGSGRGGRGGSSSRGRPGRSNDGEKRYKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M9B8</accession>
    <name>A0A2X0M9B8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C011g06295 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C011g06295</name>
        <name evidence="1" type="ORF">BQ5605_C011G06295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY11853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M9B8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY11853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="53" mass="5891" checksum="007A6FB612BA8E90" modified="2018-09-12" version="1">MTLPSDTLGLTWTLYGQAHGPYTLHHLFQTLSHPYTLSSLSLPPFPVLVFPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MAP4</accession>
    <name>A0A2X0MAP4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Elongin-C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C005g03392</name>
        <name evidence="5" type="ORF">BQ5605_C005G03392</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY74998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MAP4"/>
    <dbReference type="STRING" id="796604.A0A2X0MAP4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000035">
        <property type="entry name" value="Elongin C transcription elongation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039948">
        <property type="entry name" value="ELC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20648">
        <property type="entry name" value="ELONGIN-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY74998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="88" mass="9859" checksum="5D624D0B3C25D19A" modified="2018-09-12" version="1">MATDSNASEFRFVLPRQAALGSVFLSDTLSSGFLEAGSSTVTLGEHRSEIVEKVVEYLMYKYEYASSKEEIPDFKQRVKPEIALELYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MBS2</accession>
    <name>A0A2X0MBS2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C004g02679 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C004g02679</name>
        <name evidence="6" type="ORF">BQ5605_C004G02679</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY66481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MBS2"/>
    <dbReference type="STRING" id="796604.A0A2X0MBS2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000104">
        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002709">
        <property type="entry name" value="Probable iron inhibited ABC transporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF15">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="171"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="483"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="100"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY66481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="725" mass="79894" checksum="98922B0F787DC8B2" modified="2018-09-12" version="1">MVSQALKSAEMDDRPCIGPAKDVIHGRLGMRRRGSSRCRAPVRRVTAARLLPAVVRSSSVPHALGRVANLTQKPYLLTRVPDVVTQAPISASKAKRMAEKAAKAAAKGESSTASSKTGSRAGSKAASATNTPLTSVSAANSEEDLSMAKLRLATDRSGSGVVVSDGQSRDIQIQSYSLSFHGRLLIENADFSLNYGNRYGLLGDNGSGKTTWLQSIAARDVEIPEHIDIYLVQGEAEPSEMTALDYIVQSAKEKVARIERQIEEMSVADNVDELALELKYEELEELDPNTFEAKAGAILHGLGFGPAMMAKATKDMSGGWRMRVALAKALTIRPHLLLLDEPTNHLDLEAVVWLEAYLSTYNHILVLTSHSADFMDTVCTNILDLTQQRKFISYGGNYSTYVRTKTENETNQMKAYQKQQDEIKHIKDFIASAGTYANLVKQAKSKQKIIDKMEAEGFIEKVTERKPLSFNFEDVRKLPPPIIAFSDVAFAYSGKMQDALYKDLSFGIDMDSRIAIVGQNGTGKSTLLNLITGQLQPLQGTVNRHPSLKLAKYSQHSADQLPYHESPLEYFEKTFKPKFPDKDIQYFRAQIGRFGISGTHQTSPISQLSDGLRNRVVFAQLAMERPDILLLDEPTNHLDMGSIDALAKAIREFSGGVVIVSHDFRLISQVAEQLWEVKNKKILDLSKSDISIVDYKNTLVKNSQAEIERAKLVSKKGAAGGKINM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MBV2</accession>
    <name>A0A2X0MBV2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C008g04923 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C008g04923</name>
        <name evidence="4" type="ORF">BQ5605_C008G04923</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY78717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MBV2"/>
    <dbReference type="STRING" id="796604.A0A2X0MBV2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY78717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="98" mass="10775" checksum="10D9E746300FD201" modified="2018-09-12" version="1">MVVDAVLTLDQIDLDEALIGIKKIPGGGMEDSLLVKGVAFKRTFSYAGFEQQPKSFKNPKIVCLNVELELKAERDNAEVRIEQVSVSGGRTPIESRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MC85</accession>
    <name>A0A2X0MC85_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C013g07124 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C013g07124</name>
        <name evidence="2" type="ORF">BQ5605_C013G07124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY14839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MC85"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="1">
        <location>
            <begin position="333"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY14839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="435" mass="48050" checksum="EEE18AA613093763" modified="2018-09-12" version="1">MAVCAHCKARHWECKGRTGHLSTCCSQGKVQLPPLSGPIPSIDSCLKGRIPNARSYNKLNALHSRTPHVSDFLTPLPSTGPTLGALIPAINQRPTFAKTWLICPAEATDTQLGPDGADSRIQRSTLTKLNSTVRTGNRFSGSCASAYHLAETDAPTTFLRRAPKWRCLSAIPTPTREIVDLKTLFSRCTVIDVPMVGPSTKSLARSIRLRCLSVTHYSSPQRKIASTSTFLFARSTKLGHSLPKDRDEEEGDAENGDGELSRSQLFAYDLHKRDEYFSIPHCPQRAFLAFVMTDTPRSRPIDSTYLQLDQENLRLTTGQGIISLTPDQVGCSPSLFITVTCHPEWPEIKAALGPNDQACNRPELIARAFEAKLNRLCDDDVFGNKQRAGCLADEWRTVSLLYFVVCLFDLCSNHVDCSVLLLFEFHPPVNLTGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MCH8</accession>
    <name>A0A2X0MCH8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C007g04825 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C007g04825</name>
        <name evidence="2" type="ORF">BQ5605_C007G04825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY63743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MCH8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY63743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="57" mass="6404" checksum="0798C90F7F9C63C8" modified="2018-09-12" version="1">MALVWAWGRIPSRHGPTKKPAGQRKQGEANRGGGRESKYLWSFERATGDVASENSWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MCU7</accession>
    <name>A0A2X0MCU7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C013g07324 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C013g07324</name>
        <name evidence="4" type="ORF">BQ5605_C013G07324</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MCU7"/>
    <dbReference type="STRING" id="796604.A0A2X0MCU7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="33"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="67"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="325"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="285"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="352"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY15317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="369" mass="40525" checksum="E1085C9D43305393" modified="2018-09-12" version="1">MLSRRALSTSCSLRATHTTSTHELHFPTNPYPTPFEIFHLSPDDKLTSSSVKARYYELCKLYHPDLQQQAASSSSNTQEKGKGKSTIDPQPQRASTSDRSSEFKQIVAAYELLRNPSRRTAYLTYGDGWVRPPSTSSSRGDFRNPNGDAMGYPVHFRRGRPMASSARRPTYSSSAYDWHTSGASSSGWTDPYNSFWSSDPTKMGRTPNGSEGSTTAGTSNSSSSGWKHQGQVGRNGTIFLALATLTMFATPLAVWSVSSTLTTSNESGWMPVAQDRRHRDASLALETARREARKDSEAKREAIKRRVQQIEHARAIERADQVERIASGSMSTGHDQLPTPRKTPTRGVMARSPPSTSPSNTSHSTSGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MD52</accession>
    <name>A0A2X0MD52_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">BQ5605_C008g05343 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">BQ5605_C008g05343</name>
        <name evidence="15" type="ORF">BQ5605_C008G05343</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY80268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MD52"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000825">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001354">
        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF353">
        <property type="entry name" value="ABC TRANSPORTER ATP-BINDING PROTEIN_PERMEASE VMR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015922089" evidence="12">
        <location>
            <begin position="17"/>
            <end position="1673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="379"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="508"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="594"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1047"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1103"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1185"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1238"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1292"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1316"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="344"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="701"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="1059"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1381"/>
            <end position="1626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="433"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="987"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="997"/>
            <end position="1007"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SGY80268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1673" mass="185248" checksum="79EAD6C7100E61D1" modified="2018-09-12" version="1">MLAILLLSIQPASVSSSPLRRALFDLLPGLLLAVLVVVAAVCLVLSRPPQQGQIVLPTHDDAVPDDATAPAINPPKIDFDYEMDVQRHYRRLRVRKLATILVLLLLVSLNVFAIAWDALRGASYTSLIDSAIMIVFWSVCAYIASASYFLSNSDADIDRHWDYTFTLATLTGSALLTTTVRIILPATTSPVPSHDLPKDIYVPIMVILVANTLLQLVAFLLTGNTRRCAPLARKVQPLKASELYNDGAKTTSTSSEYKAVTEFKSCSPLSYVLFEWLSPVLAVGSKVETLSEDDMPSLAANDRAPNLWEKMRVKSGKGGPEWMNPLLYRVLSVNRHLFVWQATLAFINAFIYYLPAYFLQRFVKFLEDRNQTPGGSLRWGYTYSLGLFSAAVLDALIGGQLWFVSNSMLSTRIRVQLNTLVFDKTLRRKDVAGVSMAAQSSSEDGEGEEGGEEKGRDTGDKTDFGSKSAVLNLWTIDVDRVADFSVWCFSIIDTPMEIIIGTFFLYKLLDYAAFIGILVAVFFIPLNHWTSSAFADVQDKLMAARDKRVSLMNEVLQSIRMIKYMAFEEPFEKRILEARAFELKQLRRNYLLEVSFSGIWGISPILCVIVSFYVYTNIIGKELTPSIAFASLAVWNELRFALNAAPDVFVNAIQCLVSLRRLQRYLDTPEVEVVTTDDLDAPIEAQSPDVAFRSATVTWPQKNDAVSPSGSGSSTPAARPFELQDVSVEFPRGKMSLISGPLGSGKTLMLLALLGECDVLAGQVVCPRSPANAILLPTIDWDTFLTEENWLHPNHTAFVPQTAWLQNASIRANICFGLPFRASRYKRTLEACSLDSDLSILPDGDLTEIGEKGVNLSGGQKARVSLARAVYSRATLLLLDDVLSAVDAHTASHIYHKCLKGPLMEGRTILLVSHHVQLTAPGADFVVSLDNGRVAFSGDADGFREFGGYKLADDDEPTVESLAKHATPSAKFKNKVLVDLVAESVPVSETNSSASEAESDDEEEEDQAQVTKLDPKSKAVDVKSAPRKLIEEESRAIGTVKWDVWKLYLGLWGGVFFWIWFAIAFGGAKLADVAQSLWLARWSASYEIEADATSGRRHHSVNYYLGIYCFLSLFAVVLSTLQWFVLYVGSLRASDRIYRIILKAILRAPLRFFDTQALGRLLNRFGKDTEAVDSQLPDNFGRALMFGLGVITTLNVIASVAPTFLIGFGIVSIAYWWHARLFAKNARELRRLDSVAKSPLYSIYGEAVAGVSVIRAFGSGSRFMEIMLELASTQVTYYWTLWSVNRWLSVRFQLLSALVLGLTGVVLLQAGDTIDASLAGFALTFALSIANDMLFLVRRFTSLELSMVSVERIKEYSEVKQEAAEIIEPRPPAHWPSKGEISVEKLAIRYAPELPDVLHNISFTVAPGEKVGIVGATGSGKSTITLAMFRFMEAWKGRIVVDGLDIAKVGLKDLRQRLTIIPQDPTILSGTLRSTLDTFDEFTDLEIFDALRRVQLIKPGEREVRVEEGANRSPFFDLESEVSEGGQNFSQGQRQLLTMARALLKRNKILLLDEATASVDYKTDELITQTISEEFNDSTLLVIAHRLRTVIGFHKILLLDAGKILEYDSPSQLLADPSSRFYALCRATGRSEFRILKKMAEGKIAASHKNIKLVRRTSTGTKNVKPAAPTTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MDT7</accession>
    <name>A0A2X0MDT7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein BTN</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C004g03077</name>
        <name evidence="10" type="ORF">BQ5605_C004G03077</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the battenin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY69905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MDT7"/>
    <dbReference type="STRING" id="796604.A0A2X0MDT7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003492">
        <property type="entry name" value="Battenin_disease_Cln3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981:SF0">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02487">
        <property type="entry name" value="CLN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01315">
        <property type="entry name" value="BATTENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="247"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY69905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="518" mass="56390" checksum="DE3A33C26F34A47F" modified="2018-09-12" version="1">MPLSLSSAATTTATATPIPHRLRFGASFFCFGLLNNVLYVVILSAALDLVDKATTPKVLGPNPAGRRVAAAAPPHTQFVLGRPLATFPVAPALAVKVGWPYFGQARYGRRILSCSAISFFGIIIVATSSTLFLRLFGIAIASFSSGLGEMTYLQLTTLYGSLRIPASIDLRGFAVGWFSSGTGAAGLVGAGLWWVLRGLGVKVGLLICSFLPLCMALTFYFLLPRVETFASAPFDAYTFVVDEDEDDSDQEHDVEGEGEEEEPQVGEALIQPQAQRPAEEGEEITLTTREKLALARPLFRRYMLPLFFVYLAEYTINSGIFPTLIYEVPSPSTLVLSSLIHSLRDYYPLWQLVYQFWVFVSRSSLSILHLPPLPIALLPLPTIFQLFLLTLTFLESSRGTISNTSLGENGTIVVVFCLVSCEGLAGGSAYVNCFYRLGSEEETENKDGKGLGLGVEEGRAGDRFTSSERKRLESEFRIASVGFADTLGILMASLVATGLEPWLVRQQVARGRTLCLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MFN6</accession>
    <name>A0A2X0MFN6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C036g11528 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C036g11528</name>
        <name evidence="1" type="ORF">BQ5605_C036G11528</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000063">
        <property type="protein sequence ID" value="SGY95926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MFN6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY95926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="54" mass="5976" checksum="DBBDFBCF18EE010F" modified="2018-09-12" version="1">MSLKRGNLIFNGLELFSLPLDILFLSRASQNVLTALRSTRMGFRICRMSDAGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MH83</accession>
    <name>A0A2X0MH83_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C026g10115 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">BQ5605_C091g13052 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C091g13052</name>
        <name evidence="3" type="synonym">BQ5605_C026g10115</name>
        <name evidence="3" type="ORF">BQ5605_C026G10115</name>
        <name evidence="2" type="ORF">BQ5605_C091G13052</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000003">
        <property type="protein sequence ID" value="SGY11518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ27534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MH83"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY11518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ27534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="84" mass="9962" checksum="8E9C23BBD9A4EA3B" modified="2018-09-12" version="1">MCSYSGTLPFNFVVQLRGIMGTVVLWILPYIPKLDHRVHWRPTHFTAEHRIRGHFIAPLHQLRPLRSSLSYRVFLYPLRNAHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHR8</accession>
    <name>A0A2X0MHR8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C011g06347 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C011g06347</name>
        <name evidence="1" type="ORF">BQ5605_C011G06347</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY11988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHR8"/>
    <dbReference type="STRING" id="796604.A0A2X0MHR8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY11988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="987" mass="108350" checksum="53B825546F74C8BA" modified="2018-09-12" version="1">MTYCEITPLISHNNLINKDGPSLPCEECARLPKDSSCRAALRRQYAAGATRKYTNKKYVAGDTLLSAIYRRHHGLEEILDDNGQGIVYLRFAQGVASGEFDGANILEGLVNAATVKHDRMVKGKSMRGFVRSEALRDFEQAMALASPMALRVLQATIGASTSRKLQMRLGLDKSNMDRVCAKLEADGLTFNLHVDDTKCRSRMRTTPYYSEDLSLERELRTKGIFRHELIGLIGPPRIYETPGELPDMFSGPDPPVAGTKIRAYMIAPNDVGSPAQVFAAFVIGKTTNAEDATEQLHSVIQELIKRCVAHLLVSISADGAASEGVLQRNVAVLLRDQGGAVAQTGSRNASSYTLPSPDPDGVFPEITISTVNVAGTPIVFCRDEKHLAKCLRNAIDSGARLLFGGLGCIAYQDMLTILGGLESRRTLSRRDVTKNSTPMRSYISYVASYTMPSRTGRLSPLNVSGCCSLSDIRSRRGMTLSELAPDLALTRSSPKKRLMGSGRWLTQRLLSSATTEIFGRRNRSFPGGMAQKWWSTSSGVYARLIRQATGKVTALLELMRNFKTEAAGSRQGYHHTYNDLNDLDLVAMRTYPSDGDISLTSFAAANTARELLSGLRMWEPVQRIASNRRNQGPQPDILVEDVLAHGTTVQGSSERLGLQVMHHHPTKEDQGLLRTEMLDSALDGMRRSTCQGVVKLDPNEREAVDRAIRSLAALDFDVEAALLDVQIAYDEADRQAEERYVLETIEKANSSLRPIPTHLKLPPLVDARDTSFSLNWASLIAHRAAHECSHLRAVLLKGRPMELSDTSRGEAGLEISNTEQGRSAVHSRVLKGLVQSTGPSRFEDIAGTARSFRWTGGGQVARALTTNEIQKNAYIEDGRIQEKLPERDKQYEALAQRYPHFGSLDGAVTAATPLEIGSLICFGLKRGMHSLSCDQTAYGEEALSIGIGTFDNKPLQPRHARLVGSTLKCRHTGASPHQENMLFHTPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MID2</accession>
    <name>A0A2X0MID2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C011g06477 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C011g06477</name>
        <name evidence="4" type="ORF">BQ5605_C011G06477</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MID2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="124"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY12350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="810" mass="89225" checksum="25BF0A72A30FBA1A" modified="2018-09-12" version="1">MVGIIVEFTAPYTPEQNGQVERLNGSLMDALAVATFVLNCRPHPCIQGKTAIEVLLGKKPSLAHLQPFGSTAFVHVPKERRSKLAPRSIQGVFIGYSGEYNYRVWVQSSKQVYVSRHVTFHETPSVVTSSQDRADASDPVHHSQPPPDVLPSTPTSPVVDPTLPDPQPPPVVPIGVGQQGGYLAVVPCKDDDNDDNNGLNNGPDNYHDAEEPLDGEAEVALAPREGYAIVCTGPNPGQFENVDPSNILPAGSRCRPQPPENILPIISAIMVDVLDTPPMFHDKLSYDAYCAAVFAEEDIKIPKTFEEAMKSPYRNHWSAAMVSELLQFDHHGVFQEVKWHKGIQVLGTIWVYSIKRDANGKIIRFKARLVAQGFAQHPGINYHDTYAPVARSSTILFLIALAAAQGLYLEQFDFNCAFLNGKMTEDVYCLKLVGFMYGTKQAPREWYQAVNNLMVSQGYMRATANACLYIKHSGTSFAIITLYVDDGLIASNNQSFLDSELGSLHKAFQLKHLGPVSYFLGFEIHRTKDYILVHQSKYVRTMLEKFDFASPSKRRAITPMDNHPSLRIDATPFADVSLYQSAVGSLQYASTRCRPDIAIAVRAVAQKNSCPTVDDWAAVKRMFCYLNSTIDLGILYRNSSTTRLMVYSDASFADDPESRKSVGAYASMLAGGVISWQSKQQSMIATSTTEAEILSASSATREAIWLRRLAGDVGIPQAQPTVIQEDNAACIQIAKDPVDHMRTKHFNIAHLFVRERVASGEAELEYCPTHVKAADIMTKPLGFQRFDQLCALLGMVSLVSLTGGSVRSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIG5</accession>
    <name>A0A2X0MIG5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C101g13145 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C101g13145</name>
        <name evidence="2" type="ORF">BQ5605_C101G13145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000074">
        <property type="protein sequence ID" value="SGZ10956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIG5"/>
    <dbReference type="STRING" id="796604.A0A2X0MIG5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ10956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="663" mass="75871" checksum="8DB479C051703448" modified="2018-09-12" version="1">MVAQQHGHSRYGYQEMQNDSQQHMYPSIHETYRRMDSNFGMVTMLVPSEPNINHWQAHYDQQAWHGQLSGSSARSSELYSYHSDRHRSTGGSASSGSSVLRSPHYDVQNQHAASGLVYAPYDPSALDPHMRSLQGRAPPTPPLQTHHPRPHLSVHHASSYSAGDPSPPGSARSLGEYTALPHHMRSGGVEGHHSRATLSESWPGSFPSQQHSRDQDHHIYEEMGELDTSYAISYSCPPQSRPKSTSPHEHWQYEKEQSPLTFAPSSWSSDLYATQHQRYPAQQMNSVHSFAQDDLVGGLAQRWQWNAQSDSHLQPQPQPHPHPHPHPHPHPHRIRIRIRIRIRIRIRIRIRIRIRIRIRIRIRIRIRIRIRIRIRIRIRIRIRIRIRIRIRIRIRSLKNNVSYSMRGSSFWSGENQEEPTAPRVKEEPTASGGEQTKSRAWWTPNSSANDAASSISDYRSDSFSSQLRKVKGKMKTRKAKGNMRLASEENEPRSEGEAEGDGEIKGEGEGEGEGEEDEEESETVSANDSDGKLRRRKISEASRESAQRRYRCEMCVGEPRVFAPPSALKIHMCSRRFSIPSNLTRHRKLHLAPPHNQDEDGGVRNVRRSALEPHEVKCFLFSEQISTLQSTVLTTPMLYKCSQVDVSLYTRAPSFGEELCEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIU7</accession>
    <name>A0A2X0MIU7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-mRNA-splicing factor PRP46</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pre-mRNA-processing protein 46</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C028g10542</name>
        <name evidence="7" type="ORF">BQ5605_C028G10542</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in pre-mRNA splicing and required for cell cycle progression at G2/M.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the WD repeat PRL1/PRL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000080">
        <property type="protein sequence ID" value="SGZ13011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIU7"/>
    <dbReference type="STRING" id="796604.A0A2X0MIU7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000012">
        <property type="entry name" value="Putative pleiotropic regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045241">
        <property type="entry name" value="Prp46/PLRG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923:SF0">
        <property type="entry name" value="PLEIOTROPIC REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923">
        <property type="entry name" value="WD40 REPEAT PROTEINPRL1/PRL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="1 4 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="176"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="279"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="321"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="406"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="462"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="68"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="119"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGZ13011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="490" mass="52849" checksum="0A6047AD99445C40" modified="2018-09-12" version="1">MSLDSLPSIDDSIRRSIKRTHALFSADEAFYQVDETDRSAKLRLAAKINAEYGNAKVLPAALLVQQKGAQGPQRPAQPAGGARRPAVASSTRMIEGAPGPPGPPGPPGAPSSTPAPSSNRSSTALTTTSSNGTFSATSLPVSHQTPTLLSQSLIRRREARAVKPDYHAPWKLMRVISGHLGWVRALAVEPGNTWFASGAGDRVVKIWDLASGELKLSLTGHISTVRGLAVSNRHPYLFSCGEDKVRRSLCGRVHRLTRWFPLQMVKCWDLETNRVIRHYHGHLSGIYALSLHPTLDVLVTAGRDASARVWDMRTKAQVHVLSGHTGTIADVKCQESDPQVITGSMDTTIRLWDLAAGKTMTTLTHHHKSVRALAIHPTEYSFASGSAGGNNIKKWACPDGTFVHNFSGHDAIINTISVNHEGVFYSGADNGSITFWDYKTGLPFQTMNDLAQPGSLDAEAGVFCSTFDQTGSRLITGGADKTIKIWGQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJG7</accession>
    <name>A0A2X0MJG7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C038g11744 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C038g11744</name>
        <name evidence="9" type="ORF">BQ5605_C038G11744</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000061">
        <property type="protein sequence ID" value="SGY92520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJG7"/>
    <dbReference type="STRING" id="796604.A0A2X0MJG7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF3">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY92520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="398" mass="43178" checksum="B9A9345EBDBEBA1B" modified="2018-09-12" version="1">MQTIREKLANGLEPIRPSRRRSNMEIARICLSYGMNFMFGISAAAIGSNIPSISAQYHVSFALLSTVFLTNRVGCLILLLQPSFALVVLAFTGMGAGTGLTEPAIVTVITREQSPVLTSCLYSSFAFGAIFSPLINGSFADRNILWTNFFYIPLGLCVLLSIANVFIFRTYEADLLKAEQEELRRRTVVNFAIRYPTRPETEGQIDATREDGLTSEATHSSSTSSKPNATALLLRVLRHKVTWIGFALIVLTMSEGETLGGWSTTYFLQVKHAPAGMSRYISSGKWTDLRDRDLLIACGMQLIVALLPSWKASAIASAFFGFVIGPITPHVLSMVGSRVPSDLMAPAMSLMLANGVVGGHLNALPFVAIGLLGLSALGWLFVPRKKEEGVMAVGGDFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJS1</accession>
    <name>A0A2X0MJS1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01135 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01135</name>
        <name evidence="2" type="ORF">BQ5605_C002G01135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY30250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJS1"/>
    <dbReference type="STRING" id="796604.A0A2X0MJS1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000171">
        <property type="term" value="F:ribonuclease MRP activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034965">
        <property type="term" value="P:intronic box C/D snoRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013241">
        <property type="entry name" value="RNase_P_Pop3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28272">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28272:SF1">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="647"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY30250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="656" mass="72389" checksum="C6D4EBEADFBDBA5F" modified="2018-09-12" version="1">MAQAKLLNTHNSVRNKSKPTPNSSSQPSKAKTGPSPTPAASTGTSASTKAPLSATKAAQPQRTVYKPVLDNPFQIEWPPLPSSLRTRLLDLLIEALQPTTKADSAENGQKQDLSISEWRELLHKRKRQLASKTTRQRGSEQQDQRKGKRKEQNPNHEQPPSRRGRPSKAKKARTESSSKESEPAAASTSSAKTTNDSPPPPPTAADSTHTLTLRSAKIVTVPNFIDKPLGMPTTPSSKEVTLPSKPSMLDSLVVGINDLTRALESQIRWARWELGDREAAPSMRVEKTKEPEAVPSDKFDKAKDKEDKTSKTRRKHRSPEDHARWDEVLLGPHMTQEQKQVVDEPYRFLLDPLKNESLDLEEAAYIKRSDALSKNGSGSTFPKILNNSLAFRIKSPRSPALASGEAKSKTKTKPRRTPKTLSQKTGPSDPYYPLIDLVFVCKPDINPASLVGHLPTMCAATNGLRKAVSVERQRRKDAKGKEKERPEAGEDGDEDGMDVDEKQAAQAGAEVDEPDRFIYLIPLDVGAEHCLAEVMGLRRVAAIGVCSSSASTFAPLLSLVQEHLQPLFVPWLNPSPKPIQASTPTPTLAPKSEPRFIPTHIKHLKTTQPLNPRAAHALKKEGKKKAREERRETLSKKKGKEGKEDEVYVVDEDMDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKL3</accession>
    <name>A0A2X0MKL3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C013g07206 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C013g07206</name>
        <name evidence="2" type="ORF">BQ5605_C013G07206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MKL3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY15010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="200" mass="21819" checksum="15E94037EAAEBB47" modified="2018-09-12" version="1">MPVHLHLPSHHTIFTSTSILVFTFTLHPSPSPSHSLPPRITSTFILCLHLYVCFSPLYLPIVPPPLNLPHFMLLVFDLDLERQPRLHRTVHLLLTSSTSTFASTSGFGVTGGFLVRQSAVQDVMTGINDESTTLSTKTASAGNAAGQVRLEDGDDGEVVGMCGGSLCLLFSLVFFSRARIRPRCTATPTMVLFFVFSLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0ML79</accession>
    <name>A0A2X0ML79_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C031g10893 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C031g10893</name>
        <name evidence="3" type="ORF">BQ5605_C031G10893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000068">
        <property type="protein sequence ID" value="SGZ05840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1086"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="453"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ05840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1772" mass="193104" checksum="D5649D55D00F78B2" modified="2018-09-12" version="1">MPDPPGPPPHPPNAPWAGDVLRDESLNTETRETVTGGTVNPPAWSAQASQARLDHEKSMQKAFKALGIVPSSKSTRRLMVLLYDPSSPPSQAPALARAAQRAVRNDAMPASNVIRVIMDGTGSPRGPVQIALRKHFGLAETPFMFARPEGAELDPEVEKLFSKCVKLNPIVTKATKRFPIARHMYELVFESDQACLEAAAAGPFPYHGKEMVTELPSVSPLNHIVQVRFTLPSSSSAIPASVLRKSLDAALTSSFGHAGCTQGYTLMQLQRGLAVDPNGDPMAMTEDGFHCAYLRLHADLFQGFTETQKAALNAALPQEIEILGAKYGLRHEFETHYCAVCDRAGHQWGACRKPVSTPATAAPVPGASTSTSTSTTGFRVAGKNGKHGGPAALNSRASGTNMIQLGPRANPAGAATGNKDDANDGDGDDDDGESVASTEPEGGDTGKETLTRATTGPTKETQTTTAAPVSTPTSPSPSTSAPASPLSGGTSESSATSTTSIASTSPRRLRSSSAPGNRRVTRAGSAMIHGASGGDDSGGNSSGGYRSESLTVLTFNVRSIKNAVNQVKIIRYLKTLRPAPAAILLQEHHLSYNALREGFESAWPGACIRFAPHVLTLIPDGSPLAGRLLSSTPVVFAEAPQFDGRILRSVFRLEELDIEIINMYAPVKGEERRDFYGLLHFAAPGPKTLRILAGDLNDCPDVSVDRVAITDRAWTPASHWQTLLSKIAFNPLDTIRQLHPITPAFTRPHYLGRGDKREICSWSRIDYILVQRSWANRLLSASTLFDAPCSDHRPVVATFALPTSNAADAEPPPALPTTSEFISRLNPTVFNDQDFVASIPGVVDEVYRRLEGTASLGDVYDAALRAVAVAGHARYRSTRADMRRLRAESQSVMEALEARGEHMNEAERDAYALAKSQLDQLAVKEVQWLRIRAHVPSVDSREGQSTSIRTRLNRRSRQTSIVSLEDVDGTETVDMQEALGIASRHAQSLFTPDPARGDPTNARRSLLDPIRAAKYYDDDRSDPTFGRRLPRQARVALDEPFTLLEVEAALKKTDSGRSPGPSGIPYELFKALPTYFAPKLLDLFNSIWEGGKMTASLAEGLVRLLPKNKPGANLKSLGAYRPITLRETTYKVLSKVLVARLNGVLGELLPPAQHGFMPSRRSADAGSHLTLLLEKLKSLGTEVFPEGALLSLDQQSAYDRVDHAWIFDVFEAFGFGERFISLLRALYDPETLGVRYLINGFPTELVRLLCGLGQGDPLSCPVWNITFQPFLDALVRRGIALDLQKVWPGGPRAQLTHLAFADDAVVVVESPAALSKLETLSQTWYEATNGKTNTDKTLVLPLGPNWLRDETAQALPTVQEGESFKWCGYAFFRHGDSKLFWTHVLDRIKAKTRAAGDRTLSPSGKVFYANAHIISTVLHVLSFDIPPQWFIKAAETALTDFVWGGAGRNTVARDFVFQAREDGGLGLISIGDIVHSVALRFWDAVAGSNEAIWAPLARESWRSLVAATRDFSPWGFFSSTARVEKLYRDSTRWGAVVAAARVTLPTIKSELLTLPELLSLPPRLPSLYAEGAKHAYDDADAVAKFAQIADLYWRDEGKGWALVGHRRGFWQHSKEPALRHEHVWARVGQKLKAKALLPKTAVRPARIPLKEDPHPRCFNFFGLTRPFTIRKLRRLVNTVRFPGKDGQDRALPGGQPQEPWVKRFPEGTSQSGRQRFWSWLHDRFASAAEHGAGARVLCGGPAEAAGCLHEIASFWPSCFSLFSTTHSISHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLX4</accession>
    <name>A0A2X0MLX4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C012g06919 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C012g06919</name>
        <name evidence="8" type="ORF">BQ5605_C012G06919</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Amyloplast</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MLX4"/>
    <dbReference type="STRING" id="796604.A0A2X0MLX4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45825:SF11">
        <property type="entry name" value="ALPHA AMYLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45825">
        <property type="entry name" value="GRANULE-BOUND STARCH SYNTHASE 1, CHLOROPLASTIC/AMYLOPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13692">
        <property type="entry name" value="Glyco_trans_1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0035">Amyloplast</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Starch synthase catalytic" evidence="7">
        <location>
            <begin position="172"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="871"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="907"/>
            <end position="933"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY16591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="948" mass="104642" checksum="A9F6A9A39723DE5C" modified="2018-09-12" version="1">MVVPSGLPPATPPRRTGQGRSSSISIIPATPSRSPITRRSEARRSPPQRQAPSTRDGRELESASKLAAYKKKEDIGRRIFGLPPRGAASSTRDSKRHLPQIGVPLPRRCFLRTLVIVGTVVIAGLIVWLVAIFDREPAREPLVIPYREWDTVPYTHLDYSSPIALRPMTRLFHVSKEFGPATMGGLGVMLTSLVVAQTQSGQLDISVILPHYSYLNSIPELKDQIELVAELQVPVVSYRGHVRHVACPVSRLRWKYVDLPDFLGAEVETAEAIQERFIDIYLIGPGKSHPFHVAFRAKDSGDVYSAYKPLRQEWKDLWFASATAEFIGLINAHPTTIDGSSGLVDLVHLHGATNAMVAYYIRQQEAQNHNATIPAIIYTLHDSLDEVEYSNLVSNAVSFLSPIEHQSPLAHLLVTRLPNYVHSAQLFPAAMAVDLADMVTFVSRSIAADITEGRFTFRLQELIMPSIAAQAKRGHFVGITNGIDFTDLSKNPFVAPLLVKRGAAFPRIGSNLLRSSTLEDEALSFVAAKRRAKQALIDALPMHFSEADLRRPILLFIGRFQYNKGCEFLEPILEMLLEAQRTAEAFKDDGQAAHHQFDARLVVMGARNNYPIQELRRLQQWYPRHFTLIDDASDLQSQWGSMIRMASDFSFVPSFSEAFGLVAAEGLLFGAPVISTGVGGLAEFLVPFDKEAKKPSSAGNAHLFQLYGGVGRGEGSGTPGGELSLQADQARPSLEELDPAIRRCNTVVASAIRGWQERAHDWARVEQERFVRRLVVDALELSWHRPNGPVEEFTRVYDAALRVSRARPIGGRAHWVDHHPHPSAATLTKSAPPGIVATAVAHLPIYKIWTTDNEIRRQPQAPIVAHLLPEAANSKGNGGSGSSKKGGANGSGARNKKKPSTTSALKSHFHQKAKAHSTHHEHRKPSPHRRPKNGSKQMTAKSAARRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MMM7</accession>
    <name>A0A2X0MMM7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g02057 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g02057</name>
        <name evidence="2" type="ORF">BQ5605_C003G02057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY38660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MMM7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY38660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="87" mass="9867" checksum="74B5F88CEB96DFFB" modified="2018-09-12" version="1">MCRIGAKLFMSSTGSPPTCTWFVTRLHVEFGRAYSGHSLRSGGTTHYVLRGFLPAEIQRIGRWKSAAWEEYIRISPELNMALLAHQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNG7</accession>
    <name>A0A2X0MNG7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C014g07499 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C014g07499</name>
        <name evidence="2" type="ORF">BQ5605_C014G07499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY18881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MNG7"/>
    <dbReference type="STRING" id="796604.A0A2X0MNG7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY18881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="246" mass="28013" checksum="583D6A75EA68EC9B" modified="2018-09-12" version="1">MSFFGTVGGLAKARTTFKPRRNTQENTKSYQLKKYAEATLGSGNLRLAVVLPEGEDLNEWLAINTVDFFNQINMLYGTVTEFCTPQECPVMCAGPRYEYHWQDGVNFKKPTKMSAPEYVDHLMNWTQAQLDDEAVFPSKIGELEQRRSDTRVPQQDSCSILTSPSVLGVAFPKNFVATVKSIVRRLFRVYAHLYNHHFAQLCALSIEAHINTSYRHFLLFVTEFNLIDRKELAPLSELNESIMASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNW0</accession>
    <name>A0A2X0MNW0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C021g09228 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C021g09228</name>
        <name evidence="2" type="ORF">BQ5605_C021G09228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000083">
        <property type="protein sequence ID" value="SGZ19874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MNW0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ19874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="53" mass="6024" checksum="B2918ED6C1A0DD33" modified="2018-09-12" version="1">MVSEDLGTMMNELSDFYGTPGPLWEVPKGRRTESSHNYDADEMNEMTSVAHCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPG1</accession>
    <name>A0A2X0MPG1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C024g09814 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C024g09814</name>
        <name evidence="3" type="ORF">BQ5605_C024G09814</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCP11 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ25996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MPG1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008862">
        <property type="entry name" value="Tcp11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05794">
        <property type="entry name" value="Tcp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="597"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="597"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="623"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ25996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="685" mass="76475" checksum="1DD04BCC252C3E41" modified="2018-09-12" version="1">MPGPSPVELLASVNQLVLALQRTYLPRASVCTTPPGSRRRQRLDHLSRLLIRLQRLTTRERQDASDWISLNTLLQHVDQDFLDGLSGGIGSSSGKEAHDDGDDQSGSLPKRLEGTTLAMRNKLRQVIQDIQAYLQSTSVSTRKRRRPRDGFISSDHELEHPATGTTPDPLTLREKLDQAYALHLAVHDPLKLEQHRRIGPLPPAPADAEGSQEEGATVPSLSTASQILSRLPPHWTETTLSSLRSSEPEVTLDGLKALLWKHADSLIPSRLGHGNLKPLLRDTLLAPTPRPLSYATFKTRILHPLFELLGRLCSPARDDQARTLMERLDKSKQVEHVVALMLDALVLIDQMHLDLRFARKLAKRHLGSEQLDRLEMEKKAIESERRVVWQILKNKEWGTTVLPETGRWIRERGGAEAGSTMEKGFRKALLEAVFDTRAVECVDINSTTSTSTTTEGGSSHRLPLTLLVPASRIFTLQNHLQALVIVACLNSIVSSNVALGSTSQERSNMTRRLWTLLQGIVASDSESNGKGEGEIKLVNLVDEVMQLHRGKPAWEKVTKEENMEEGLKRRVESVLRYEDPVFKLFSRRLKEGVERELDRTSSTKLGEDRNVPRELKTGRQLLSSSSTPSTPSTPKPEAGVVSIKGFEDLQEPLGQVLVQLQAILDWAQKVWGEELGWTRSEVSQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MR03</accession>
    <name>A0A2X0MR03_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C001g00522 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C001g00522</name>
        <name evidence="9" type="ORF">BQ5605_C001G00522</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YSP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY47328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MR03"/>
    <dbReference type="STRING" id="796604.A0A2X0MR03"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140268">
        <property type="term" value="C:endoplasmic reticulum-plasma membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120015">
        <property type="term" value="F:sterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13220">
        <property type="entry name" value="PH-GRAM_GRAMDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051482">
        <property type="entry name" value="Cholesterol_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319:SF4">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1042"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="8">
        <location>
            <begin position="787"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="256"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="338"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="477"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="681"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="974"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1062"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1115"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="91"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="366"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="420"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="684"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="710"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="735"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1062"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1132"/>
            <end position="1149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY47328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1174" mass="124362" checksum="8345D6A7450C7723" modified="2018-09-12" version="1">MLSRLRRRSASGTTPERQQMSSSNGATSSNGTGSGASPLLGPPRYDDDESLYSPTWNEEQSMSSSSLSSPTTSLRRPKHLNVSHLGGTDHSPSGAASPGAPGGPHSSTTSPDSSSASMLARSPSSASSTRGKYSLPSAGPSPPSPNMPRRKSRSGSVSSYVEGGNLSPVASSSAAAAASQQGRSTSRTFVPGKTKGASNRYFVVNKTTAVDESLDNFGSGSLSLDHLTGGASDPAALATGGATWVARAPELISLDVGANPGAPGDPSRLSQSSSEDNIRTPMPGDGPTSQPDAYFGVAAPVEQRPQSVPSSATASPVVLSKGGAPFNLDRLLPLPASEHSFLPPAERGGRARSHTTSEAPPPFANRPSTGIDTNLTHGLPPPSLSARPNMETTPRNSVMVPNPVPAADQAAAAIEKRPTSRSSSVTSSDTSSPALLRPPLQSSPTSSIKLKRQKSAQGIAGAIAVSGMALAATGTGFRQAGSLSRTSTRTSFEERGSGAESDGGVSNGGGDQYANGFSLGGYEDAMTSLGTGYAVASSKRNAEFHQLFKNIPDDDYLIEGECWEGTKLFCLTRMLTCALFADYGCALQREILIQGRLYISEHHISFNANIFGWVTSHTLPFAEIVSIEKRTTAYVIPNAIQIVTLHARHTFASFLSRDSTYDLICNIWRMIHPVVPPSAALPDSADRAGSVHHDSDEDEVDDDGSQPTKKSGKRRLRGLRRRGGTNEERKGDAVASTNSGVTSTHVNGSTSRMVNPSSSSLGGPGGPSKPAAVLHAVTADRCPTHKDLKEVCMDVVFPSAPEKIYNLMFTSGFMRTFWTENQKLMDLHISDWAPEKSDSNLLARNLSYIKPLSAPIGPKQTKCMILDETAHVDFDDYVCVITTTRTPDVPSGGSFAVKTRTSMTWARNNSCRVVVTTGVVWTGRSMLKGIVERSCIEGQKTYHVDLENAMRAYIQLHRSEFLEEGQEPISSLVTENENNDAQRMDQDESDKDDDANEKIGLVHRRKSRAAPMGGVWGIITDAFSDLTGGGARSSGGGLSPTPLILALVILILVLSNLWTLSSRPRSTSPSLSPGSRRSSARSSPSTGHDQTPDQIADAIRDVLRDYLASLPSREYAPNDATTLPVSEEDSSKEDGIEAPSKTDKACAPRETADIGQILDGLQVRLDEMKLKLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MRA9</accession>
    <name>A0A2X0MRA9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C026g10135 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C026g10135</name>
        <name evidence="2" type="ORF">BQ5605_C026G10135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ27590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MRA9"/>
    <dbReference type="STRING" id="796604.A0A2X0MRA9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016082717" evidence="1">
        <location>
            <begin position="23"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ27590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="107" mass="11428" checksum="39383346F4EA56D1" modified="2018-09-12" version="1">MKYSLVFVALVVIATRIVSALAADATKQASTSEVDYPYFPEEHAATVSQGPPTRPITHPVASTLNESLVNCKAEKCTACKGEAWGTCIEQCASWMAHQASQPEPEGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MRE4</accession>
    <name>A0A2X0MRE4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C026g10175 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C026g10175</name>
        <name evidence="2" type="ORF">BQ5605_C026G10175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ27730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MRE4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ27730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="96" mass="10478" checksum="1B815FE59EE7323B" modified="2018-09-12" version="1">MTGPHGCQNYEHVTGNKCTKRTSVKSAPLPRHSGLSRPPTCNFVSLGQRFRTPKNRLGNQRAGEGGGGGARWSDRRQGRTNHSLTSDLPHASSPKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MRG9</accession>
    <name>A0A2X0MRG9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C018g08624 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C018g08624</name>
        <name evidence="1" type="ORF">BQ5605_C018G08624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY25483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MRG9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY25483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="72" mass="7738" checksum="B47F383A9E9FA6B1" modified="2018-09-12" version="1">MEIGGASITVVFLSVGSTMKTIRVDRILEVGFGGEEHPEGHDNAQDDSSEIWVGSEIRVGSEMGRSTSFKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MS22</accession>
    <name>A0A2X0MS22_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="7">3.2.1.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C001g00892</name>
        <name evidence="10" type="ORF">BQ5605_C001G00892</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="7"/>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY50517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MS22"/>
    <dbReference type="STRING" id="796604.A0A2X0MS22"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000033">
        <property type="entry name" value="Glucan 1,3-beta-glucosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF34">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY50517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="889" mass="96068" checksum="0AC6B6A41AFE4C75" modified="2018-09-12" version="1">MSSYPPHRGQGTEDMMAGGGHSMMDGPQPTSANLYAAVPTNHDSNLAYAAYSTPYDSTMTEEMDPALGSPSHVHDDVPTSPPTRSHSVASYSDHHGGSYARYDGPAASTYSLGVDGQSQLGLNPRSGSGLGVYDKYEDHEMGDKTSAGRRGTANVAGGRTLVKKGTTGFWATLSSRGRKFLLLAVLVVLLLIAVAVAIPTALVTRNNERKANNALAADGSWSAAPTTLGSAAPSSAAAPLTTSATPTTTAFQGIPTGANGSADWRTAPFGGDGSIVYTESGSPFVYNNSFGGFWVSIPFNDSARAQDDVPPLNEPWDYSTTLINGVNLGGWLVTEPFIVPALYEPFNAASDSRTATNRAIDEWTLSEALSTSLTSVMTNHYETFITEQDFAEIASAGLNWVRIPIAWWLVEAWEGEPFLANVGWTYFLKAIGWARKYGLRLNLDLHAVPGSQNGYNHSGRQGTVNFLNGVMGIANAQRTLDCIRTLTEFISQPQYSNVVPMFSVLNEPLGLLAIDVESLRHFYWETYLMMRQITGYGTGKGPFISFHDGFMNLNSTRDGGWMGWMPGSDRVSLDTHPYLCFSEPNNDGMTYQAAKPCMYWADKMNVTTQQFGLAIAGEWSLAINDCGKWLNNVGNGNRYNGTYYLPNTGATTPRFAGVGSCDVWNDYTRWNQTIKDGFRLVATGHMDAFRHWFFWTWKTGYSNTLGRIANPMWNYQLGFENGWIPPNPREVVGACQSLVRNNGFTVALGSNPAPTLAPWMTGGSGAGTQQNEAMSRSYTRWPPVSLGTLNAANLPQYTPTAPVVTMPVATPTSYPNGYSAVTNPGNGWHNTGDAKGFMTEIAGCTYPDPWQGVSATVPSRPCTGGARMVKRNIVVERGPAPTPPPRPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MS66</accession>
    <name>A0A2X0MS66_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C050g12499 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C050g12499</name>
        <name evidence="8" type="ORF">BQ5605_C050G12499</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000097">
        <property type="protein sequence ID" value="SGZ29766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MS66"/>
    <dbReference type="STRING" id="796604.A0A2X0MS66"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051260">
        <property type="entry name" value="Diverse_substr_monoxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011:SF16">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="7">
        <location>
            <begin position="69"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="505"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="521"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGZ29766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="547" mass="60028" checksum="48393EFABB975938" modified="2018-09-12" version="1">MQSYESTATPLPTTSTTTPTSNGRAPRPSSNRTNGHVQNGSAVKKRWILNAFDMACAGHQTPGLWKHPLDRSAQYHTLEYWTELAKLLERGKFNGIFIADTLGAYDVYNNNPDAAARTGAQWGVDDPTLLISACALVTKNLSFGVTQSVTYEHPYTVARKFATLDHLTKGRVAINAVTSYLTSAARSYGLTDQIEHDERYARAEEYFNVLYKLWESSWRDDAVILDKARDLYADPSRIRKIHHEGKYFKCEGPALVEPSPQGTPLVYQAGSSSAGLAFGARHAEAVFMSGPSPAKIRIQVDALRDLVEKEGRPRDSIKVLVKLLVIVAETDELAQSKHDEYYALASREGAKVLFGGWIGQDLGLYAPDADLREVGTPPVKGVARGYAALFPEVEKWTADVLGDHIKVGGMGYAVVGSPKTVADQMQQWIDETDCDGFNLCYAITPGTFEDIVNLLVPELQRRGVHWTDYPQRPDGQGITAREGIYGVGEVKIDDRHYGAQYKWRAGQDVPPSLEKPGSLISADSEATETATAGDSESTVNGKKRKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MSQ7</accession>
    <name>A0A2X0MSQ7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C047g12323 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C047g12323</name>
        <name evidence="1" type="ORF">BQ5605_C047G12323</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000113">
        <property type="protein sequence ID" value="SGZ31165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MSQ7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ31165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="192" mass="21628" checksum="D5FDCB10AEA7294F" modified="2018-09-12" version="1">MGFTICGKQFASVRTHGRRDHSIRPDRLFHASRLPLLDAAHPRRRPSIARHHLAGVDLLPSRSFGATFSPTSHSSNLGIGNVRLNSNLKLVQRHYVHPAMLGSRARVYTVKLRGRRSPTVHTAIVSMVDEVRAIRFNKIFITIQAARFDDSYELPQLKHWLLNDAHYRSAPPMIAKGDAGCHFGPRAVQYVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MST1</accession>
    <name>A0A2X0MST1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g03988 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g03988</name>
        <name evidence="1" type="ORF">BQ5605_C006G03988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY55216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MST1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY55216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="85" mass="9561" checksum="F89EC620F94634E3" modified="2018-09-12" version="1">MDPKGVPPFSRETCPGRVLGSVRKRTLHLASSAQTICHDGARPRSRTSQAAHQCGPRAERKKIWDSWIVECAHRWLALSSKQRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MT01</accession>
    <name>A0A2X0MT01_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C048g12400 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C048g12400</name>
        <name evidence="1" type="ORF">BQ5605_C048G12400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000110">
        <property type="protein sequence ID" value="SGZ30532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MT01"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ30532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="61" mass="7031" checksum="8680694A97176260" modified="2018-09-12" version="1">METQGLEPWTSRKSLVSGQYPRVKARLVSLYWIAFLSAPTAQQPALEIQPREDIRRCRGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MT09</accession>
    <name>A0A2X0MT09_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C047g12331 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C047g12331</name>
        <name evidence="10" type="ORF">BQ5605_C047G12331</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000113">
        <property type="protein sequence ID" value="SGZ31194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MT09"/>
    <dbReference type="STRING" id="796604.A0A2X0MT09"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15486">
        <property type="entry name" value="ZIP_Sip4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF78">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="95"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="225"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="302"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="979"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1250"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="356"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1025"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1250"/>
            <end position="1261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGZ31194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1274" mass="136663" checksum="CB672A3BFEB5240D" modified="2018-09-12" version="1">MSPFQDPDQDEASDLYSDMSDTGGGAAVDAVNVPSGGGASTSGSGLNKSSSLKGKGKAPATSNTKSTGGTSTSRKDALALTAEEEKDIKRRSSKACDNCRKSKCKCARPIDPETGHPVGVCENCLQAGTECTYNGASRKRGPPKGYIEAIESRLHRMEALLGGLLQNDDPRAQTLLGELIGAWVEPRVVSGAVASPERADECTRALSLSGDEEARDVLTNDLKAASTAAPGAKPRKSWKRAEEAAPAVFPASTSTAAAQTPGLDFNTRPSWFHDDDLAFGTNMTGLVGGGVGTSLALDPSGFGGPRVSSKAESEESGSIHGASPGPFGAGIDMGQRPVLSTSAGSLPIPMPHLTEAGSAGAAGAAGAASSPRQRRRLNHQSPLTGTSNLVGANVDELKSFAFGFGQQTNQGHLNTRQVGHTGTASYSLSADAELSPSGGANPGESEAMSSMSELADVVGQLSLNENSEVRYHGRSSGLYLISKSARYKDFFWSFPSAGVWPPADGRVRKTEREILGLDIAEDALPDKAAQQHLLDLYWTYVHPHFPIVYKVSFLRGYRHRMSHPETDTRPDNTGINKIPLVLLLSMFALAARYSDLDGDRTEGKYWTAGDVYLERAKKLLDYDYGSSRLVTVQSLLLLAYREIGTGAMSSTIRMAQDLGLFRDVEKWFLPVQRFSHEEKQTRKRVWWGCIILDRYTASYIGRPGTIHERDYDTSFPSEDEPDEHEQFVPLRPDGTEWTCPPKSPESEAVPTRAYPQAKVHAMSCFSAAGALAVVINRVSASFREMWIIANIYAIRIRVLGQSSETLLSLLDQSLASWYLALPPQLVYSPASKRVPPPHVLSLHLQFYSALILLHRPFIPGQNSEVSPGNFPSHSICSTSAIAIANIIQVFRKTFTLRQCPPFLTYPLFSAAIIFVYNASFDEALARPAKMYLAQCMDALKEMELIWGSAIRQWELLYGLVDLSEVDLSADLSMMQDEAEAALRGTKRPAQPDSGTATPTRFIARPIGRTPATAAAMVPKPRRKSSSASRGSRTTSSGAPLASSPSIPETAPQTIAFDVLHPSATNATPSTTDAMMTQDMHGLFDHLHAGVASTQPSTTVQTSSPTLPAEPTTGQTLQQHATMHTGQQHHHQTYDIMSPSGQMLDMSQFRSPEGSNSTTNFQDLLNSFLSPTETPNELSHLPNSLQPLQGQSGSGATSRGMFESTDPSYAGAFQGFPMGVHMSENWAAYLRNNFFSSLSEGAGTDITPGYPGRGAGPGGIAGQGPLTGSDMSPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MU26</accession>
    <name>A0A2X0MU26_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex component SEC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C002g01627</name>
        <name evidence="7" type="ORF">BQ5605_C002G01627</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the exocyst complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SEC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY34408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MU26"/>
    <dbReference type="STRING" id="796604.A0A2X0MU26"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029175">
        <property type="entry name" value="EXOC2/Sec5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039481">
        <property type="entry name" value="EXOC2/Sec5_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15469">
        <property type="entry name" value="Sec5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC2/Sec5 N-terminal" evidence="6">
        <location>
            <begin position="135"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1010"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY34408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1059" mass="116462" checksum="D18228F15CB7F479" modified="2018-09-12" version="1">MQGHGGGATPPLRPGGVRPSLEPRSQQRPSLTDLNSRRPSNNNSNSNTAPSSSRRPSRNGQGHRNDNGNGNDFDEFDKVNHGDLAWQNDEQAMLSLYGLTTLAPTEWQDAEAVDGTFSETGQPTTTAAATKGDEPDPLGLMRGGVLASNPDLPTELRSAVLLHSKTFDPKVFLSTVHPNATFKDLNKGRDRLKDSLEQRSGALKLLVQAEWDRFVSVKAATETVYEEMRQPRGPLAADADHGVKQIRETLKVASTRADNVFQPILDARTKAERLKSTLGVFERSKFFFNLPTILGEAVEDGRYEVALQAYKQGRYILASRPAQLLGLPVATTPQQQQQQKRIYDKVWGQVEKIIGDLRATLGKRLRDTRRGLDEVEKTIVLAHSILLELDPTDDPVWIFFDTQHRHILQLLRTSAEASTSRIRIAMDNATDEMSAPDWDRKSAADLRTCVASLEALDGEGVRENAAGSDVWRLIYDLVRNLNEVILQNLPSFWKVAKGYMEGKYQKKVSSNSSSNPGVRRSPTQCRVMSQDIVTLYVSLLSTFFGLSSASASPPMLPDPADPNAVPPLPSFVPPTANATSNCHWLLRTLHEMVDCASDLTALELAGEASQSLKELVGTSRWRFEEAICSSWVRDAKVFFRLETWHPDPDEPSTTSYLRRVAAFQRFCAISAYRIAGGTEERAQALMGSNASSNPSNQLGSRSRSDVSLPTEFVKKIQAAFLDGLYAFLDGLVHVAFSDPEHIFASPAPGSKNGTSSMARRKLVTTGEDGRTKEVDIRNVDIRVLLTVSNLTHLRETSIPRIINQFQSAFKIDMASDVQMLMDVTEQLDKILFDDYVKRKSADVAKILRKGVLGGTVDWFEAAKPTEVHPFIYDALLSLVLVHAQVSATARPLVARTLGSLVEELAIVALDAFGKVERFGMGGMLQVSRRAPFNATLEIEFMHQTLSQHVSPLADSTLQSIYKTISQSYYRRPTPDSAQELQKELEGLKRTLVASRRATALQFLCFRKPSAAKKDTSGGASGEAVSSPVPGSPAPPVPELNRTRRAAMPPPSGLASLPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MUP1</accession>
    <name>A0A2X0MUP1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C067g12832 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C067g12832</name>
        <name evidence="3" type="ORF">BQ5605_C067G12832</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000135">
        <property type="protein sequence ID" value="SGZ35330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MUP1"/>
    <dbReference type="STRING" id="796604.A0A2X0MUP1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24121">
        <property type="entry name" value="NO MECHANORECEPTOR POTENTIAL C, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24121:SF23">
        <property type="entry name" value="NO MECHANORECEPTOR POTENTIAL C, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="230"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="324"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="377"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="470"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="531"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ35330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="580" mass="63243" checksum="B59F2F15FF52AB80" modified="2018-09-12" version="1">MAHAHGPLSGLGTLGPPSRRVLRWFPRHSCASATQIPNTPLVPDWFWSLSIVAHGVRFAATLASLSASQRLRQALVDPKSTITHLERLANKVEDVRNINPSTRQTSLALAARAGRLDVCDWLLFDEGHEEIEISRDAAGETILHIAAANGFVDLLNMYLSQYPFVLDWVDARGATPLHIAAMKGQLEAIQVRTGPARATLPSIHESSFGNWRYSQILIHAGSEIDVRDMFGNTALHYAASWGSLPVIKLLIELDCDYNAINGEGFIPYEYAYSFDVARAMKEFYEDRIVERSRKAKRRRARRARIAAPSPSLSGESVAHSDNYAYESSSSMERDPSPIGICLGSPSRSGPGDTLRPAPRQNQSGSSSRRTSQREGPNGSSKRNSATSDLATAFNQLSELPDSNASRSETPSRLNLFGRKEGGSGDGRGLPRSPISPPPVTSLSPTDLSLDGRRSDEGISSASVAPRHRPQSSVFPSQSTLVAKQDGPPIPTRSRTLDPLVPGHTLFTVRSDERDPSSSNRMRLGKLTKNPSSGTATSTAMGTELDQTSLVPGVLRSRTTEASYRRLHMEGGRRGWPKLWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MWH3</accession>
    <name>A0A2X0MWH3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g02579 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C003g02579</name>
        <name evidence="1" type="ORF">BQ5605_C003G02579</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY41870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MWH3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY41870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="166" mass="18334" checksum="DF00A0EC606CAC14" modified="2018-09-12" version="1">MKSFSSYNVTTSHSRASLVLAYTDSPITVSSELFDIASNAARPEAILMSLFTPGASIKAKLGQAISLATTKDRSATLQLGYQLDHLLTFDEWQPASFLYAALMAVIFKTTNAGEAFLQHFSRVAMRATSKSWPLWLEYDIVVRANFWAHLARSCSDTATPLPSPHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MX89</accession>
    <name>A0A2X0MX89_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C001g00264 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C001g00264</name>
        <name evidence="25" type="ORF">BQ5605_C001G00264</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY45219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="510"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="257"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="785"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="267"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGY45219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1398" mass="155441" checksum="1A07CEAAC0FA84CF" modified="2018-09-12" version="1">MSPSETIAQESGEIKIAKLGKDNYELWSIRVEAYLESKGYASVLEHGHVRPSDVSLAEWRTMHGLDASVTDTQVVVNLQKKDRSARALIIQCIDDANLKMVKSKTLSAKDIWDKLRQHHEGNAKPFKIRTLLMELSNAKYDEDENMGEFLKSMIDKADQLDDLGQKFGDEAMIAYILQALPPSYEMLKQAIRLGENRSVDHVINRLTDEYTERKLSGKFDKLLKNAGALAVQSTQASRDPNCVCRGCKGKGHFAMDPECPKYDAKKNHGRARNRNKKKKQDSKESADSNELAEFVLTVKSLDESHSLQDNVANRVSQLNQGEIWILDTGASQHYVGDASLLSNRQSGNLKVQTASGQVVHCDTYGMVRFKLKSGASLSLANVYHLPGAPVNLISTRALFKSGAKCGWEDGKDVMTITYQGVILAKTLSGTGYALDFTRIVEDQAHVATRATVGAPLMEWHRRYGHVPVSSIMELVKSGAVEGLVLTDEKVHDCEPCISSKSRASKFSELATQVTDVLQRVFMDIGFVAEDQVDFQGRKAYLAIVDQYSTAKWTFPLKTKSAEEVTRVWIAFRQGVEKMTGRKIKRVRTDNGTEFTNKLIGADFQSQGILHETSAPYTPQQNGTVERFNGSLMAIVRAVLAASKLSWKYWLYALAYATFVANRILHAKLEGKTAYEVFYGKKPKVSHFRPFGSTVYAQVPKSKRSKLESTSVKGIFIGYDSEYNYRVLVDPDSDHKVIVTRDISVLEHKSEQVGVPEVTTLPVGPDEEKGPVDNDEIVVDELQDQVDGEQMPPARQNRPRWEYGDPAVKGRNPGRYEEIDANNEIPHRTRSQRRDAEQQVMYGSAMSVSLPPVPSNYEEAMASPEADKWIAAIKAELDAMARHQVLIDSDLPSGARALGSKWVFTRKENAQGEVTRYKARLVAQGFAQRPGIDYNETFAPVARPSTILSLVGTAAAQGLFLEQFDFDSAFLNGTMTEMVYMKYPKGWDRPQTGQALRLVKSMYGTKQAPPVNSLMVERGYKRSDADSCLYVKRVDEKFIYITLYVDDGMVASNDQEFLDSEIEAFNKVYKLKRLGPVKLFLGLEFERTSDYIFVHQSKYIRDLVAMYGGGSVSKHPVKVPMEPRSDVEHSTDPFDDVALYQSAVGALQYAAHRARPDIVTSVRAAASKVSAPTQADWIAVKRIIRYLQGTVDWGLKFNHGGSTVFELYSDASWGDDMSTGKSIGAFVSILAGAAISWQSKQQSMVATSTTEAEILAASAAAKEAMWLRRLAADLELEQPKATLIWEDNQAVIAIALNPAHHGRTKHYNVHHFYIRERVTAGDIRIKYCKTGAMTADILTKPLARNLFELHREGMGMVGAGARVLCGGPAEAAGCLHEIASFWPSCFSLFSTTHSISHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MXY5</accession>
    <name>A0A2X0MXY5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C005g03494 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C005g03494</name>
        <name evidence="7" type="ORF">BQ5605_C005G03494</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat WDR59 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY76496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MXY5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049567">
        <property type="entry name" value="WDR59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049566">
        <property type="entry name" value="WDR59_RTC1-like_RING_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46170">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46170:SF1">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17120">
        <property type="entry name" value="zf-RING_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="167"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="258"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="RWD" evidence="6">
        <location>
            <begin position="614"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="552"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="982"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1147"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="561"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1024"/>
            <end position="1033"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY76496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1368" mass="147731" checksum="E3FA23FB7655C926" modified="2018-09-12" version="1">MSLSPPPHPTAAANAATNAEPAPDLETSPGRDTSRSESHLEGSLHKSSIRSGLQHAPAPFEHDDDHDTFHQMLSIHLDQPVGSMSISPSNRDVALGARKGLFIVDLQNPWDPPRFLPHHSPWEVADVQWNPFPARSEWVVSTSCQQVIVYNLDFSPSLASSHIEHTLHAHTRACTDINWSPGCAEILATCGLDGWVFSWDLRTGYGGARKPVWGVCSWGSGATQVKWNRREPHIIASAHDNKVLVWDDRFGAAPVTEIRGHDAKIYGIDWSRKDPKNLITCSLDKSFKSWNLDSPSQSLLAVQTSSPVWRARFLPFGDGVLTLPQRTDHGLSIWGLDRVVQGRTAEPVARFEGAREGVKEFVWRTRGGADLDIDDRQFQLVTWAKDRQLRLWPISDEIMRDVGHEKGSPITIPMTRRGGGNISYRTYTDTITAPPPPFSIVPSPAPAVPRHLVTGPSLLSATLPNATSPSSSLLASSLLAAKQHPIAPPLIHSAPPLSAELRSGAATMTTSSVRSRKQKAHARLAWMEGVRIIKAPTAAPQSDLDAINAASCERTSENGDSRTQTRSSSLQRGTDGGTAREGGETERADSVLSPGSTKTGTAHAKDSQFSNLGEEFTTLTRKFPRVRFEKCSVASRSCTVSLYSPLFLRATFTFPRQYPHSAPPSIELERNADVTLKSRAALLQGVRKLMAGRAQRGAHSLEPALRFLLGDRSVLDETRELVGEDDDDDEVDDALEDGVTGNVPAGVVRLNLRVNVPPPRRCGASFGARGQLVVFFPIDILDGPVGIEHGPAPTENVDRSTHPHTVTRLSEAFGAVATEPRQAAYQETDEALQLVTEHTMRASATLDALPFPSGDQQSAPAFSTLVKIKNVAHLDLSRGGRVLCPLKDDLVAVTRAAALSSAEDNDMLLVKVWSSLECLLQAGSESSDVGMDEISSLLAEMLPNVMAFLVHLRDIATLGVIACLLEALTRYDMATSENSVVDAEPPTVDNFSHRNASPLGSGDGTPFDSRQTPLASRGAFGTARPSSSSPKPSWANLSGFFNNTVLSLRSGVSSASPGSLDRPVHLAQPASISSLNLLATANTAQFSPSTKASKRTMPEDAEPIEAFPLNSGETRPSFSKQPILRTSRTGKASPSVVTFGQTRVALISGSGPNPAPNQVGVRRTRPCGRGEGSGRIITVAYSTSSRILRKPAWWLSDRARLELELLRLAYADLLHRWGFHNERLRVLKYCFSVTKPISSRRGFITEIIATGSGLGPSSSISIHRACSSCRSIAKATSKTSRPCNHRPETRPASCSLCHLPVTSLSSTCLICAHVAHTSCSRAWFASESVCATGCGCDCLNSGGIAGVFVVRESHSENVSQQLIMHCQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MZC8</accession>
    <name>A0A2X0MZC8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g03800 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g03800</name>
        <name evidence="2" type="ORF">BQ5605_C006G03800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY53775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MZC8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY53775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="431" mass="47770" checksum="2AE4E5D2714071CB" modified="2018-09-12" version="1">MVASKSGLAPSESARKVEIATSKPAWTSTSLERTSDKLPEDSRSAPRVKFAPPKTSTSTSLGEDGPVVIFQGPWSNNSCWIDSTLIALLSVANGLEPWLQCLDILNTHTAYVIPPLGNEMVLRLRPRYLALELWDVICEYTALARKFDMKPAANAIEAYTQLRERMISTVVGMLKERGSHFTTPFERGSYSSPVTWLETLHSFTVDHPVLPSAVTLNDPNRTLVELHLQQAGYCTACNCIQIEVSPRQQFVVDWPLLISSLHLPSHSLETLLDVLASIVGQPLKLYTEAKNSGRWHHKRNCPGGSYVQFVSITSLPRVIMININNIYPEHSLAPAELRFGVSDQMPEMVWRLRSGVYNINNSHFVTNATVGYGQEAACYHFDTIKGSLARPTGDRNAGGLVSVLFYKLEEEALNCCCRSVSSYVASIDDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N0F9</accession>
    <name>A0A2X0N0F9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="2">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C006g04180</name>
        <name evidence="7" type="ORF">BQ5605_C006G04180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="2"/>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY56844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="6">
        <location>
            <begin position="1140"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="5">
        <location>
            <begin position="1441"/>
            <end position="1502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="440"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="837"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="458"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY56844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2034" mass="230124" checksum="08A6D25EACFA9A05" modified="2018-09-12" version="1">MALRPLPEDQLHPMDPPPMNAAISRRSQGQQRRRQRESLQRERSVPVPHSVPPDPVFAKSTNQSTSRRTEQNNCIEQSPPPEPTPDVHSVPQRQPHSPEPPGARSVRARLHPPATQSPMALRPLPEGPYPRHDLGPMDLLCPKCSAFHWDFERLGGRQNSEFRSCCDDGKVELPKIRKPPNTLLELLTGDGQGMLDIMPLFFGAVHLTKTPCTVCTVEKLFRERILAFNENLAMASFGTSQDYGIIGAGGPPSFYLSGNVYHRMGTLAPARSSNPVFAQILFVAPSERIDARIRFNGPSSDDEQQLVIAYRQILPRLDEMMLQENRRAQQFLMAREFINREDAHAYQLRLLAPRNRDPRRYNLPTQDEVAVILPGDETEHRSSSWEIVVRLRSPPYGDTTSGLQILPDKHPAVMSLTYRLLLPFGEDWYQDNIPFSQNASTSLADRRTRDADGVLQRTHGSGSTTADNPQTGRGGSKHVTPLQFNAYYFHIWPETVSFPTLFLGGQLFQKFVADAGALTEQDRLQWITTNQKTLRAEEYSSLQASLAEGIDPSEIGKRVILPSSYPSSPRNMVQLYKDAMAIVRAFGAPDLFITMTCNPAWPEIINALLPGQTASNRPDIVARVFQGKLTACLHDIYGDHGRPGVFGRVVAHVHVIEFQKRGLPHAHILLILHPDEKPKTNEDFDRIVTAEIPDQEKFPTLFETITNSMLHRRCDLPGQHTCHDKYGKCSKGFPKQFQDRTTSEDGGYPHYRRRNLHQFINYLYDLAPQSLPLASTCFHEFLSLSLGFPSTINRASYSYKNNYINPTSRPVILAIACCLRLSNLNPDSRSRFPIDLVDLTQASLDSLIDQLRTLQARNQALEAECRSHLSDKENYQITVTALANQQQTLSDFAKAVVDQQKESIDVIKSGLANLNVTAPANTTITPVKSQLAKPDKYDGKEKVKFKTFITQIKFCIFGNPSSFPTDESKIAFIISHLTGDAFQHFEHAINAKDDSKPEWLTNYQKFLDQAELVLGDPDYRNNLTRQLMSLVQSGPASVYASKFTQISSQLDWNQAALIAHFHKGLKLGLQAQLALHDDPQDLQSLIELAIKVDNKLHLARHRTNASTQFRQTNWQYSHSVNSPLRTSPVSQLQANPSTANTSKPWSSLSMDHIVDLPPSSGFDCVLVVVDRLTKEAHFIPTHKTDSSRDLARTFLTHVFKLHGLPTDIVSDRGATFTSNWWSEFLAMLKIKPNLSTAFHPESDGQTERTNQTLEHYHRHFCDYLQTNWSELLPLAEFAYNNSFHLSIGASPFYVTRGYHPRLEVSLRDSFVTDVPKYLQHLRSVQETARKQILQAQETQARFANLKRKPSPPFKIGDQVLLNRKNIQTSRPSSKLDSHKLGPFRIQRIISPAAFKLELPASMKIHPVFHVSLLEPYQANSLASRCSNPPPPPEIINGEEEYQVEQILDSRNNRRSRRLEYFVDWTGYGPQDRQWVSAADFDDDDSLVIEFHTRHPHKPGFERIQGLNGARASSYLYDLAPRSLPLASTCFHEFLSLSLGFPSTINRASYSYKNNYINPACRPFPGTEWEEIYTDVNVVPTNPWLASKYDCHINVEIANGVAAVKYHYKYVYKGHDRTLFTVEAGAPRNEVKDFLDARYVCAPEAMHRLFQYQMHGHKPAVTRLALHLPNEQQVRFDPEDGPLTTAAPPETTLTAFVKLCATVPPVPKAQNVLYLDVPRSFRWDLNKRAWQERKKNTPAIGRMYFCGPEAGERYYLRLLLLNVPSPTSFAQLRTFNGTEFKTFREACIERGLLQDNTEANRCLTEAAVFHSGHQLRHLFAMLLTADGGVSNAAELWETHHNSLSDDAEYHLLMRRGQSFITPEHISSWALLQLEQILQRLGTSLCDHGLPLPTATFKNELELSRLMMEERSTPEEIERMNREWMKNLEAFTVEQRHAFDTICDSVFNAQGKTFFINAPGGTGKTFLETTILSRIRSENKYALAVASSGIAALLLPKGRTAHSRFKIPIDIFDDSTCNVHKQGQLAELFRACELIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N165</accession>
    <name>A0A2X0N165_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C007g04431 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C007g04431</name>
        <name evidence="1" type="ORF">BQ5605_C007G04431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY60440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N165"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY60440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="66" mass="7504" checksum="4F18B660CF3800AC" modified="2018-09-12" version="1">MATRYHFTQELVSNGIIELRWIGTKEMVADGLTKGLSRVPHESFVRMLGMVDAPRQGACWKGLREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N1W2</accession>
    <name>A0A2X0N1W2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial import inner membrane translocase subunit TIM16</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial import inner membrane translocase subunit tim16</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 12">Presequence translocated-associated motor subunit PAM16</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C007g04721</name>
        <name evidence="14" type="ORF">BQ5605_C007G04721</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIM16/PAM16 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY62686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N1W2"/>
    <dbReference type="STRING" id="796604.A0A2X0N1W2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005341">
        <property type="entry name" value="Tim16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388">
        <property type="entry name" value="MITOCHONDRIA ASSOCIATED GRANULOCYTE MACROPHAGE CSF SIGNALING MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03656">
        <property type="entry name" value="Pam16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="131"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGY62686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="166" mass="17345" checksum="4D50EC4AC63B2057" modified="2018-09-12" version="1">MSAPRILAQVVVLGSQILGKAFVEAWRQAARNAQGTGRAGSSSMNGGGKGSSALDSLTRTHRMSLDEATDILNLKRNADLASETELQKMLKNFDHLFKANMPTTAEGKPHSSHYLQSKIVRAKERIEAEVGVKKGDGGATTAETAAATAAEGTPGSSTTGRTPPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N5E7</accession>
    <name>A0A2X0N5E7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C005g03696 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C005g03696</name>
        <name evidence="3" type="ORF">BQ5605_C005G03696</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N5E7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="2">
        <location>
            <begin position="299"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY77683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="598" mass="65989" checksum="5EBCB2CD62055B09" modified="2018-09-12" version="1">MYQHTVVSAAPACGVGVPIRSHVRKGKRAGLESRSNSSSPTFLQGKVQLPPPLRHNLECRQLREGSDSGQLLRPTTVVCKAIALRENARSYNNALSLTLLAAHFDQAQLGIQGPRIPVVNQRSSLCSNLAQAGDTAKEWVLRLCLPPGRDRRTHNLPPPSMEMTMLICNSDTNTGDRGPQELIVQGCKENSSHLNTPLCGFHQAGPPIARNREQIDNGVQLREVLPVSVWTTNEEDKDRNDEDEDRKEGDEEDGDGKRQRSSKGVEVASLAFTILCALLAKGDEYFSIPHCTHGPFLESVIYGYTPSRDQSTLHIRLHQENLHLTTTQGINGLAPNPIGRSMTLGSTFKNRPRDITQRYQDAMACVVKHGKPPLLITMTYDPNSPEIKAAPGPIKHATVRISLHECSKPSPATSNMQAVSAMNRTNRENLEQWATHVLFFPAGQGIQLSVNPTLFRGPNGKVMAPSLFVNASKRHQVFIFPPIFPNGHQKVFDLPEQRWNAWWKAWRKVCRVHSDAEDTGHLLSLGSLHPGSQVTSPTSPHPNNRSASCVMCLSEAPECLAHLAVGCPFARRLWSALSPTPHPVFVDFVCPVVSRLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N6W3</accession>
    <name>A0A2X0N6W3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C009g05408 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C009g05408</name>
        <name evidence="7" type="ORF">BQ5605_C009G05408</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY80931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0N6W3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14003">
        <property type="entry name" value="STKc_AMPK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="46"/>
            <end position="306"/>
        </location>
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    <feature type="domain" description="UBA" evidence="6">
        <location>
            <begin position="586"/>
            <end position="627"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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            <begin position="317"/>
            <end position="405"/>
        </location>
    </feature>
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            <end position="490"/>
        </location>
    </feature>
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            <end position="551"/>
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    </feature>
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    </feature>
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        </location>
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        </location>
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            <begin position="1405"/>
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        </location>
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            <end position="95"/>
        </location>
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        </location>
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            <begin position="687"/>
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        </location>
    </feature>
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        <location>
            <begin position="777"/>
            <end position="792"/>
        </location>
    </feature>
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        <location>
            <begin position="795"/>
            <end position="807"/>
        </location>
    </feature>
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        <location>
            <begin position="884"/>
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        </location>
    </feature>
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        <location>
            <begin position="935"/>
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        </location>
    </feature>
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        <location>
            <begin position="962"/>
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        </location>
    </feature>
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        <location>
            <begin position="1064"/>
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        </location>
    </feature>
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        <location>
            <begin position="1150"/>
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        </location>
    </feature>
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        <location>
            <begin position="1166"/>
            <end position="1191"/>
        </location>
    </feature>
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        <location>
            <begin position="1192"/>
            <end position="1201"/>
        </location>
    </feature>
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        <location>
            <begin position="1218"/>
            <end position="1228"/>
        </location>
    </feature>
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        <location>
            <begin position="1242"/>
            <end position="1251"/>
        </location>
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        <location>
            <begin position="1266"/>
            <end position="1290"/>
        </location>
    </feature>
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        <location>
            <begin position="1362"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1414"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY80931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1446" mass="154843" checksum="25DAAE8BC0BA7CFC" modified="2018-09-12" version="1">MNRPGGSRRGSRHAQQQTRAGHELSQAYSSLAAELTQKELKSVGGYTLGRVIGEGSFGKVRIGVHRLTNTRVAIKQVPKSSPVNSSDRGSAASSPLSLLTRELHHHRRLRHPHILALYEIIATESSIYLVTELCTGGELFDYLVEKGRLSASETRRIFGQLVLGVAHLHQSGVVHRDLKLENVLLDERVNVKIADLGFGREFEKGRWMDTWVGTLGYCAPEVVAAKRYHGEEVDIWSLGVILYTLLAGSLPFDDDDEGLMKEMILKCEYDIPTWLDEDAIDLIQNILVLDPMRRLTLKAILAHPFFTRPPPLKLPSEPSYHHLYHHGHRRDASPHTTRDAFPPAIPEEGSATESPLVDESALMASTSSSTGHVNLSASEVSADSSYLSISGSEPERTRSGATTPLTSEEDGLAALQETLTAMNARKAGKQRAVDQDSSDENGVLLHRNASQTTICRNASMLMEDSQSTTSDPIPTPTTRSSKSCTTPLSTADENELTIPAVPSYASLIGLCAPPLQRNLSASSSVSFGSQTGSPAAVHSRTPSRTKRRSVGSTFSERLFPLDEEAPMQLVNYFAMLSEPHPAPLTTPQEQALLDSLTTLGFDTGQIVHSITTHACDSSAAVYWMLKRKADEREREKLESEAAAPVASSPASLPRSLTSSIRRVPSTDVIDEVAGADSATTPPAPTFVSPTTSSQRTGTPENGPPQGEAPQTPDERAQERLSYFLHQTPLSSLSLASFDYFPPAGTNPSPQRRVVHSKSHERNLLADSVESKGTSRSPSPPRVHVPTASPPPMVGRTQSATNETTTVASPDWSKTKRQRSSSTTMLLARATSAIGLKKSTNESGPNDEEDRSDSPAGSTKSPGSFFGRKGSLPSEEMMTPGAGTPSKSAPSSPRRASAGNSLSTPSLSSIMASSTSALEAGGGSTGAALQEVTLDPGSSTMVHSNSHETFSTVTSAAATGEDGSIHDLDRSTSHTAATKAAGKKKGAKAGNLFSNLRLWFGDDRRKATATKRGMPLGRVDSVASTLSRSCSRRSALGSPPITRSAMDGRSSSGEYYRLNFGSTGGTISRRSSVSSVNRSGSMNQSSSLVHRKRLSDTSIATSEPRSRPGSVRSYSYDGSRRVRDRRRSSLSSHGISPKDVAKHQPITTTVHRSRSRANSHHHHHGHITGTHSRTRSISSVNTRHSSSSSIGGDDVDVGEGVEEPSKGKEPIIEEDESNINDLDSSSGDATATVGPGADEATEEERRSNERNRALRLLSGDTKRRSTGEVSVANSISPRVSLESTRPHTPTRFTAHRTTHLFGAPSQPAATKSKSHESAAPHAQQSSSVSILPRRPPIRDVFVWKEGQEWEDEDDEPSGGFGQAPSSRLANDNSKMAIGTGVARSPSLGGPALAEMRKFADLPAARPGMTAEQGGAASGGTVGGGRQPYWRRPAGAAPVMIEEEEEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N6Z3</accession>
    <name>A0A2X0N6Z3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C022g09513 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C022g09513</name>
        <name evidence="2" type="ORF">BQ5605_C022G09513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N6Z3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ22642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="166" mass="17727" checksum="72BAFEED1F9F12C0" modified="2018-09-12" version="1">MVSEGTVKLVHAPLFGLITLIGIVTLAMSASLVSHYNSHGYPTMSYRDRIRIILAGAIWSLFVSVFLVAGVAVKPDNILFGIFAHLIGLAIAFILLLIGVASLTALTDKIHCSGIENFSRCKVVKGLVGVTWTQTLLLFIALIFVFALGVKARSGGGMRRSTLVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N6Z7</accession>
    <name>A0A2X0N6Z7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C009g05448 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C009g05448</name>
        <name evidence="2" type="ORF">BQ5605_C009G05448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY81055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N6Z7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY81055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="291" mass="33041" checksum="1494F0ACFD744F76" modified="2018-09-12" version="1">MGIPLRMLLDKREPFFPYSLAAFFWKLPLCTLLYYKECEQIWQAVGEATWVELVAYKDALAQYNAQRDAQLRQQSSWNILSSDMWIAWREQWATRSRAGSDRNKIIQDTGIGEWRIELVPLLKRTRIAPLTFKRVICYSILSSSALDPRSIYQGIQLSPPRARPAASPIRRPQRALAERDRRALMFGSKPSAASAPTRSGFFPELRVPKTGAFTQDELRHLRKRGIRLEGIEDFELEFENTVDARAMIIPDDSEIVGVPALLPPSSGGSGHPRPCHRAPAARMEGKRVVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NDW1</accession>
    <name>A0A2X0NDW1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C023g09647 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C023g09647</name>
        <name evidence="8" type="ORF">BQ5605_C023G09647</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ23856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NDW1"/>
    <dbReference type="STRING" id="796604.A0A2X0NDW1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF5">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="529"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="566"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="608"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="639"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="672"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="702"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="198"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="58"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="459"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="469"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGZ23856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="746" mass="79358" checksum="E7121C52BF1E4743" modified="2018-09-12" version="1">MGSADVPPIPTGATTASSLAHADSTTGTRLPVDVDVIISAANPVASVVAESMIAAAEHASPGQDNNSILRPEVSQDGKVGSTRGRQLLVDASQPSESELTATPVDLKHNEHEKAIGTSGTSPDAFNSSSPPLTPQLDQAANMEDDEVTVVGRPPSVPVSHVAEDPEPPRQPPAEQLDIEHLEVTNDPRAWSTKRKNLILVCIAYNAAGGLLSSSIYFPALKSLQTDLNASDSLVAASVSLFILGQGVTPVFWSALSEIKGRKTCYITAIIIYLVATTVCSRADKIGVFVAMRLLQSLGSGAPLSLGAGTLSDIFDVHERGTKIGFFYGVPLLAPSLGPLLGGALAEAGSWRTTFYFLIGVSGKGRLDQLPGWCTELDPCRVDPQYGVICLMTMIWLSVTAYFNLKGKASETDLTPWSAASSCSPETFRRERSLAWRLAMKRARAHAKADRLKAEGALPKSDTLPLTRGPPQTSFAPGPQRSNGPTATPTLARVMTALSGRSGDDNVKIHLRDINPFAATGAVLTQKYNFISIAFSGLLFASTYCITFTISRTFAAAPYNYSAVKTGLVLLCLGTGNFIGSVLGGRYSDYVFNKLKAKSGGKGSPEMRIKSTRLAMVLVPCFYILYAWTVQKRTNAAGPLVALLFLGISIMVLYSSLLSYIVDANPGRSSSAVACNSLFRGVLACIASQVAEPIIGHIGNGWFYTGFAVILTVGSVALLYVGANGQRWRERQLERSVHELDPSRTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NM83</accession>
    <name>A0A2X0NM83_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C010g05951 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C010g05951</name>
        <name evidence="5" type="ORF">BQ5605_C010G05951</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NM83"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="298"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="594"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="777"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1035"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1165"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1255"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="38"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="619"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="646"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="782"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1166"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1177"/>
            <end position="1191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY13705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1279" mass="136290" checksum="5A28934F73AD3E3A" modified="2018-09-12" version="1">MDPLTTGSASALSPVPASEPTPTPVPTTETTPAAVVLSPSTTPVPTASKSSDRTPSPLSAAATSFIGTSDTTDLPSSPLASSATPAPPLSSDAPVAAVSDPENVIAPAPQSSSNGLVLPPAPHRRPRRRHAPPLKGILKPPTAPSKTFSFRRDILQSFNSRLAYATSLSANTTAAAAAAAAASSLASSQDRQGHPDGSTPASVVPAAVALGNGVETFKNVVTAAAGTGHGAAAAAGGFFGSAFKRFSTGVSNVATGGHAAPLQRDLTDDPPTPPHREERYAPVLGADIASSVLHLPTESATQDSVSQTEHKLSHGGPAPHTPARANATSGKAATSPYATIHASAHASSPTSPSTPPAPLPLAVEELKRVRFRMATLKVVYPINGPNGPIAPYEESRTRKRINFAHRESQQLKASEGGDAKGWTGEALGKLYAECCRTREERPNERLRRIFVVRRLLEPYLVWCELADKYSLKDHPVAPPRVLDLTNEPLTHGAVEALSDLLSVDFGLKKLVLENCGIDNDSIRPLVHALLVSGSIPTISLANNRRIRNKGWKYLAIFMRKASFLRYIDLSENVVDRKTTEFIVQSLVPHTIASLPPAPVNGLNSAPAVNGHEPNPEGGVRGEDKDLPDQPPRETETEPEAEKGEQEEAVVEEGELDEELQPTFSVAPLLKEDPTNRAGSVVSMRLENCGLKGATLEALAHGIRSSTLKHLSIRRNRIQPLGGVALAIMIRDYPIAADHHSEQDLNSPSMLSSPTIKNSLSLFEGGNSVTARLALREPFTKRTPPSNGVATAPAPSTTEPEGFGRLTTNGHGPSEATLKLRRQIEELPRMGSLLTLDVKNNDLRHGVTYVAQVLKRNRTLKVLNLSENKIDMQGLVAIAEALKYNNTLETLDLSYNPCCGPSLEGITSLRTAITINSNLKRVFLNHTDLTSEGAIALSEFLPEARSLIHLDLTGNNSIDIAGVMALSVSVKMNTTLRCLDLNIPPNDPDFARLSQDILQCCIRNTEQAQEEAASGGKTITIAAPILKSAVARDLKERQEAQQRQERRREMQARSKDEIVQAAEGVRDVLADMLAVDEELARTGVIVQPAEVVRDSLVQAQLAEAQLAEAIAATRPGDQKDRAVLLGDALSALLDRAKALYEPKVAPSTSQVTPTGTVEAESTNFVLDDSDSEDDDSAPATSNPETGDATSKATDVAAPNEDAVNDDDNEMSIKTPLEFQSRSLTLEEGEIFRKGSALGTGQVDDDDDELDHVSGEELKKEIMEATVERSSRGSFEERPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NSI1</accession>
    <name>A0A2X0NSI1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C011g06289 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C011g06289</name>
        <name evidence="1" type="ORF">BQ5605_C011G06289</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY11844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NSI1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY11844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="192" mass="21898" checksum="298728DE4A7DF84C" modified="2018-09-12" version="1">MMNVFYKKYIYPAAPLEEILPKPVARFAMEQRLPDPAFTNTLGLKGPPQPDDLRSFWKAVNSKALTAREREVWFKLILRFTPTRKLQHQQNHDTSPAGVLCDALGCDTIEDAQYTTLQRLFGLPKLKAKLSEQEGAGRTIEIFTGMVLEMISSGRWRIQKHGTRMESVERRRVVLEERMKLRAGGARGGRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NSR9</accession>
    <name>A0A2X0NSR9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C016g08036 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C016g08036</name>
        <name evidence="4" type="ORF">BQ5605_C016G08036</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY20387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NSR9"/>
    <dbReference type="STRING" id="796604.A0A2X0NSR9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052432">
        <property type="entry name" value="PITP/CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN CSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN CSR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="3">
        <location>
            <begin position="151"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="322"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY20387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="454" mass="51047" checksum="07FD3A472B1032BE" modified="2018-09-12" version="1">MGNPANPLPTDGVVGRLTDRQEKDLKAAWGEFLDLIDNAPTEGNGKTTSVEVNTDKGSQPKGDDAKAAARAEQERADAAAAFQEYGSRRFVASFWRLVAMDDPDGIMLRFLRARKWSGSAGVAMLCACIKWRMGGDVEKIFEKGEEGMKDAEGFIMQMETGKTYTQGTDRYGRPVVYIHVAKHRTFDQSPKALEDFVVFQMESVRCLFSPPVDKIVMVFDMTGFGIRNMDWRCILFIVKCLEAYYPESLNVMLIHNAPWVFQGIWKVLGPMLDPVVRAKIDFTKSTDDLVVHIPRNHLVKELGGSSSWTWKYPPIKPGENAAQQDKEGRKRLQAERDDLIEQYTELTRQWIKSDDPNIAKQRRILMFKMRAQYFVLDPYIRGRGAYHRHGNIIGNGLVTFDYPSASGESEGEWETSGYETCKEQCQLEATQLEAELKAAGVSVGGGSRGGKRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NSZ4</accession>
    <name>A0A2X0NSZ4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C010g05945</name>
        <name evidence="6" type="ORF">BQ5605_C010G05945</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NSZ4"/>
    <dbReference type="STRING" id="796604.A0A2X0NSZ4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000824">
        <property type="term" value="F:inositol-1,4,5,6-tetrakisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008440">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF108">
        <property type="entry name" value="KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="253"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="277"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY13693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="365" mass="39616" checksum="467A3E3844C04C70" modified="2018-09-12" version="1">MPLFAQVGGHASTITSTGSIINKPSSAREKAFYTQLAPSLLPGFIGEWTPEFYGTLSLQGQMGQDGQIAPVTEGELGTKPKEMLVLENITYRFLRPNVLDIKLGTQLYDEDASEEKKLRMDEAAKATTSAQTGVRLTGFQVWDDASKAYVVTPKDFGKAITVPELSGGIARFFYPPHGAAYTPPTPVVSTHAAAAPRAAIVPTPLPLELLVPVLNGVLARLQELLHLLDDTEIRIRGGSLLLVIEGDAKALREATARSEESSPSARPSKQDRGGEGDVGDTEEEDDESETESVSTTDGEGNAKAHTRLPWDLRLIDFAHVRAAPGEGKDEGFLKGIETTVKLIEDLRDWLEMEMEMEETTTQDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NVG8</accession>
    <name>A0A2X0NVG8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C002g01094 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C002g01094</name>
        <name evidence="5" type="ORF">BQ5605_C002G01094</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY29905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF486">
        <property type="entry name" value="RLK (RECEPTOR-LIKE KINASE) PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="3">
        <location>
            <begin position="316"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Retroviral polymerase SH3-like" evidence="4">
        <location>
            <begin position="655"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="894"/>
            <end position="1125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY29905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1385" mass="153330" checksum="A16D959C7720C5A5" modified="2018-09-12" version="1">MSSASESDSHNGAGNRLYLKDTKGYKSWASKAYLNLRGDVLWDVVIHSVDSLVADYRSTLVSANATASGSAPSADVLPTLTSVQIADKVAAFRDKADRRNELACKFLANALSEEQMGHCEHLDSAKDTWDTLKRIHSLSQSSRTMDLLSFVNTVKITMIDFKNLDGPLPNWLFAAMLVRSLPDQYDSIVGNLASDVDIHMDWNAFYPKLLVNVELAESRNRQKASLSDGIVDDGSLVARISTTAPKDYSKSYCSRCKVHGHERGWRLCPSRNNNANVSAPPSDSNSNSNVAAIGVDETALMTYTFPHSKAMPVFPWIIDSGAKVHCVGDRSVISDFISEPLGISVADQSRLDSPGHGSVTFLTSYGCRIILKNVYYMPGAQCGFISIDRLLESMTYVVGPQSNLIFSVRGKSILRSRPGRGFIMDAAPVQPILSSSPPSMVAANRLTGTCTLMEAHRKLGNQSPAAIVLAVKSGAITGITLKDEKSTEAPHPLYRVFIDLGFVEHSNHHGDTIYLAIVDQYSTAKWTNVLKDKRAETIIGAWTKFQAEAERQTGHKLRLESNLVPFNKIKRVRSDNGREFNSSKTGKSNDLMALMGLVRSMLLDSGLPMRFWSDALAVATFVLNRRPHPCISGKTAIEVLLGKKPNLTHLQPFGSTAFVHVPKERRTKLSPQSIQGVFIGYSGEYNYRVWVQSSNKVYVSRHVSFVDTPPRAPSVVTSTQDRVDAPIPVLDPRPPSPEMLPVTSVSPVVTPPMGADQPRGDLGVVPPMDEEDEDHDRLEDVHDAEESLDGEAEVALAPREECRSLQHPSCWLSSSTSTSRQLLPIITAIMVDVLDTPPLFHDKLSFDAYCAAVFAEEDIEIPKTFDEAMKSPYRNHWIEAMVSELLQFDHHGVFQEVTWHEGIRVLGTIWVYNIKRDANGKIIRFKARLVAQGFAQRPGVDYHDTYAPVARSSTILFLIALAAAQGLHLEQFDFDCAFLNGKMTEDVYVRYPKGWNGPKSPGKCLKLVGSMYGTKQAPREWYRAVNDLLVSRGYMRATADACLYIKHSGTSFAIITLYVDDGLIASNDQSFLESELVSLHKAFKLKRLGLVSYFLGFEVHRTKDHILVHQSKYVWTMLEKFDFASPSKRRAFTPMDDRPSLRIDTTPFADIPMYQSAVGFLQYASTRCRPDIAIAVRAVAQKNSCPTVDDWAAVKRIFRYPNSTVDWGILYRNSSTTRVMIYSDTSFADDPVSWRSVGAYASMLAGGAVSWQSKQQSMIATSTTEAEILSASSATREAIWLRRLAGDVRIPQSDPTIIQEDNAACIQIAKDPVDHMRTKHFNIAHLFVRERVASGEVKLEYCPTHVDAADLMTKPLGPQRFDQLRALLGMVSLGSLTGGSVRSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NXS2</accession>
    <name>A0A2X0NXS2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C003g02006 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C003g02006</name>
        <name evidence="25" type="ORF">BQ5605_C003G02006</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY38355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="497"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="769"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="820"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="845"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="23">
        <location>
            <begin position="863"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="875"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGY38355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1898" mass="208581" checksum="7E288C030B36A80C" modified="2018-09-12" version="1">MPGMSDNALKSSTLAVPPPRPSTQVAAFAASDLLRNTNGYQDWVLTLCSRLPSNVIDYLQSGVPLSSWPPSYVSLWDHYARASICAAVDPWMVLPGLSQYFGDPCSGHKIWVALRMRYGAVSAVDLLPVISLLFSPDPMPDTADEFLQFCDQFENDSRLLDDSKVTTDSLLASHLLARMPSSLSAWRTTFVNSQGTSRTLPPAAEILNRIYREIKARPIDSPVAATTTSQQRVPHSPCPNPSCRKMHWLRDCPDTAWAAAFRARKAAAGATLQNHKKGSRAVASPAITSPAVDEKPEPATFTACLLATPSAFPKSAWLLDSGANRHMANDSQLFSTLRPFAGPHVAGVAGSLPSTGCGSVRLSTSAGPVVATDVLLVPSLPCNLLLVRRLDRLGFTTSFSSGRVTIRNSSGTVVATAQAIANDLYALTVAPSPCMPNALLATPHRVSLLTMHRCFAHLPVVQLKSVVQKGLVTGVDWVYSEEEVRSFNCNACLASKVHALPFARSKSIASGRLDLVHVNVAQMPRASFGGHRYMLVIVDDYTRKHWCILLTHKSDVFHRLCAWILEVENATGDRVKTIRSDNGGEFTLRNFVDFCVAKGIRRELTIPYTPQQNGRVERTNRTIKEGILALLYLAGADTRLWAEAATYFVHCKNLMPHAGIRGDIPDTRWYGIAPDVSSLRAFGCRAWHCLPSVKRTALDPKAVLLMFVGLDNHAKVYRLFDPATRKILLSRNVVFRESEFPALQSVADTHTGTTPLPVAADIHPEQVDHSAPSLVASPHSLAPRAEPPGPAPTASDQGPRRPLPARVLPDQDSHARPASDQGSLPASDQGSPINRTGGLPDQDSPDTYASDQGSSDSAISTPCPSPRPVVPRPLPASSSPARSESPDPIDLLPCLGDIASVCLAPKFPDDLDDALHSPPPVTHLASGAVALLNTAPTDSTELIAPARDPPHWRAAMATPQADDWRLAAQAKFDSLSRDFSAFTPIDESLVPADARILGSRFVFRTKRDQHGQVKSYKGRLVARGDSQRSGIDFDETFAPIAKFTSIRALLALAAVHGYHIHQADIDKAYLHGKLDKPLYICVPDGVYMPGKVLQLHRSLYGLRQAGRIWNDEIDSALSALGYTATESDHCVYVRAASDEHHYIALYVDDLLMISPSLPEIKRTLHGLEQRYGVKQLGEAEYILGIQIRRSNDGSITLSQEQYLKDVLARFAITSLMYASTGTRPDLAYTVGYLARFSRSPSAAAWGAIKHAFRYVAGTLSHGLRYTRGDPAPLVGYSDCNWGACLFSSKSTMGYNFTYAGAAVSWSSCLQSRVADSTCDAEYLALSHAGKEAIFLRQLFGELGLPSSQPVLIYGDNQGANALTKNPVFHACTRHIRPREHFVRDMVSMGNIVVQYIATSKMTADIFTKALSRDLFARHRGRLVVWFINTDKTVVLPIGRRWDSWERPLVVKAAGESLEWIGLPFNPSGNAELAYANLIERLEATLEAVQHRWLTHHTRAFYVNRYAIPKILHFLAANIPPPEVVKKLNDMLVDFVCGGKGRTRYGRDIVFTAKLKGGLGVIRMQDVVDAVAARIWDILLGALGFPKQQDAQVNPRTLTTTNLLALPTLLGSLHTPFRGRQTIDADHIPDYLRLQGYPKVADLYRRELYAGGGFHLWTPPVDVLGDNSEYNRRGLPQQLACAAWYRFTVDRHKNTPLVVAVVAGRLNVPPQIGTSAPLEAIIPKPVARFAMEQRLPDPVLPQQASQYKLLNMARPYTICHIRRVLNAKAFTNTLGLKGPPQPDDLRSFWKAVNSKALTARERELWFNLRTLQPRAPFFASSAFHRHLQQYQTLWISPLPVFVVQHNTSQPRWPTKSLALCASQCDWPACYNSPARLPDRTVSIPCLLTPFFLFSTASQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NYB9</accession>
    <name>A0A2X0NYB9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C003g02206 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C003g02206</name>
        <name evidence="3" type="ORF">BQ5605_C003G02206</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NYB9"/>
    <dbReference type="STRING" id="796604.A0A2X0NYB9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019632">
        <property type="term" value="P:shikimate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089:SF1">
        <property type="entry name" value="BIFUNCTIONAL 3-DEHYDROQUINATE DEHYDRATASE_SHIKIMATE DEHYDROGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="SHIKIMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="2">
        <location>
            <begin position="12"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY39372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="377" mass="41360" checksum="712743219F96EBCA" modified="2018-09-12" version="1">MSSPPKRTEFYLFGHQISHSASPAFHNEIFSALGLSQHRYQLHDTKHPQNDPNSRMIELIRRDDFGGASVTMYVQYGEVLSLINATSPKPIKVEAMKHVDNIAGEAKEIGSINTIVVESIDKNGRPVLLGCNTDWIGMYKSLLLALPISQQALKAPFSPSSSPSPKSGFIIGGGGTTRAAVVALSRLQISPIFLINRDPTETAVMIKSFPQYDLRALDHVDQWSEEWVERGVVGVGAIPSLEPVTEGEKNVYTVARKVFGSKPTGQVGQRTFLEMCYKPRKTIMYNIAVDAGWYGVQGVESMIQQGYEQSRAWLLSSAASPFQGQRKELGEVIEHRAAAFVRGMEDIEPVGQDSKVTSPSSVKLAPQTGARFGQARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NYL2</accession>
    <name>A0A2X0NYL2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C011g06459 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">BQ5605_C015g07838 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">BQ5605_C017g08303 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C017g08303</name>
        <name evidence="1" type="synonym">BQ5605_C011g06459</name>
        <name evidence="2" type="synonym">BQ5605_C015g07838</name>
        <name evidence="1" type="ORF">BQ5605_C011G06459</name>
        <name evidence="2" type="ORF">BQ5605_C015G07838</name>
        <name evidence="3" type="ORF">BQ5605_C017G08303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY19769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NYL2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY12301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY17627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY19769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="50" mass="5378" checksum="48F5D966D1D2A561" modified="2018-09-12" version="1">MAPLLDVRVSELFASSFDKPANAPGFSLNSFHGRQTSLSSLNPLLGRSML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NYQ9</accession>
    <name>A0A2X0NYQ9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C017g08353 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C017g08353</name>
        <name evidence="9" type="ORF">BQ5605_C017G08353</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY19858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000003">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Chromo" evidence="8">
        <location>
            <begin position="1336"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="302"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY19858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1406" mass="158784" checksum="81A9F980E73C14ED" modified="2018-09-12" version="1">MEDLTQASLDSLIDQLRTLQARNQALEAECRSHLSDKENYQITVTALANQQQTLSDFAKAVVDQQKESIDDIKSGLANLNVTAPANTTITLVKSQLAKPDKYDGKEKVKFKTFITQIKFYIFGNPSYFPSDESKIAFIISHLPGDTFQHFEHAINAKDDSKPEWLTNYQKFLDQAELVLGDPDYRNNLTLQLMSLVQSGPASVYASKFTQISSQLDWNQAALIAHFHKGLKLDLQAQLALHDDPQDLQSLIELAIKVDNKLHLARHRTNASTQFRQTNWQYSHSVNSPSHISPVSQLLANPSMANTSGPAPMDLDATRSRRGPLSKEEKLRRRTNHLCMWCASDQHLRAQCPTAPPMIPGHTALNASPRMSCTGTLFPQVLSPPSPRYSQQNSTRFPKTTLFCPLYSISSPHSDLATSFVHNNHLQLIAHPTPIPLYVIDGRPIQSGNITHFVHLEVQFNGHTQSLCAAVTQLGTYPLVLGMPWLRLHNPIIDWKRNTLVYSCQSCALGHTQLINVSIEGAPLVPLDHKHLDISFASSFVFERLVNNSDNHHGLLFYDPASHQLSSSSPAPSQSLSDNNQDSLEYLESLKNLVPPEYHHLLAAFSKVKADQLPPHRKFDLSIDLEDNTTPPFGPLYPLSETELQTLSSWLKENLSKNFIRASTSPAGAPVLFVRKKDGSLRLCVDYRGLNKIARKNCYPLPLIPEALDRIRGAKIYTKLDLRSGYNLCLVMPFGLTNAPAAFQHLMNSIFRNHLDVSVLVYLDNILIFSGNESQHTRHVQEVLQRLINNKLYCNPKKCEFNRASTEYLGYSRVIAPLTRLLKKNTPFLLDSAALSSLDQLKQIFTSGAILCHFNPLLPSIIETDASDFAISGVLSQVTDGHLRPVAFMLRKMLPAKQNYEIHDKELLAIVECIKIWVLTRRQARWSETVNHHKYTIEYCSGSKNNKADTLSRRPDFSEGGKASEQPGQILLHPHTLAASLVKFSPPSDIADLIKFHLSQDPVSNQIVNDLNHDSTLHPYFKLQDNLLLHHDKIYIPNAEPLKVKLLAQAHDSLLSGHPGQVKTFELLDRNYTCQRNKPTHHRKHGHLQPLPIPSKPWSSLSMDHIVDLPPSSGFDCVLVVVNRLTKEAHFIPTHKTDSFRNLAWTFLTHVFKLHGLPTDITNWSELLPLAEFAYNNSFHSSIGASPFYVTRGYHPRLEVSLRDSFVTDVPKYLQHLRSVQETARKQILQAQETQARFANLKRKPSPPFKIGDQVLLNRRNIQTSRPSSKLDSHKLGPFRIQRIISPAAFKLELPASMKIHPVFHVSLLKLYQANSLASRCSNPPPPPEIINGEEEYQVEQILDSRNNRRSRRLEYFVDWTGYGPQDRQWVSAADFDDDDSLVIKFHTRHPHKPGFERIQGLNRACP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NYW6</accession>
    <name>A0A2X0NYW6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C016g08120 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C016g08120</name>
        <name evidence="3" type="ORF">BQ5605_C016G08120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY20677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NYW6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="394"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="599"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="295"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="458"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY20677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="825" mass="89198" checksum="C0855A66E6E066A1" modified="2018-09-12" version="1">MSGWDQPETSTHAFCDWGSNESHASGEWGSTERDSSSSEQTRTSASSPYPPHGTTAPSIASRRQQAPHNQAVRSARGNPPRGSSFSSSSTMVDVPLSLKSDRSRYEVGDSGGTASHGGGWIPTPSPSEAPQGPPEFDQQQAQWGVSERRGDTADKTAYDNSAEGAWSINQPDLNHSPTQDSGGSGGWFASGFEQIPPANLKPTTGARDTTAGSSSFRPNATPYEPVDSGTSTTKNSIAESSRRRKAQQASKVSPEEGDFCSSAASIETESWNPDVTPNTYSRWAPEGYVPPPVKYPMKVLRQISSDSSASPPPSTASGHSTAKAASSPVEGNDPSAQIGVTSPPPSPSLSKLRNEMFKPSDADTTRPRSDQATRDLFTVATLEHNSRVVASIQRDFSESDLAKREYTMKSDEPEKMIRSASLLDTPPHLKLKAPAQSVPAARGGAGMSRGDRVDVRQRSSPIQESPPASVQAESPRTQRSTSLGFVESPKPLETSPWSRNATGGGHGSPACTDTTWTKVGSLGADTSSSTSALHGMKGLMDHLREMYAEKLELQGTVRSLERDLAAQHQRTSIAEAQARVHQHKAHDFEIRLLEAFDKRALLDSELEDLQTQNQELRQRNAELITAAEERVTAETSTKSATALRDPDFDKHYKELEAAKTALEKDKTALLADRSNLVTRLNASELDRASLTGRLLVAQQDAMEMGNQLALEQRETARSQKVEAAMVRENKSHSTEKEEESLVEAVHSSPHQKVGATRRYSQDELLALRTSPLIEQHALELSAAAQESRDLLASAPPERSTFSNSDKSPEAQSITILCAYHLTQRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P054</accession>
    <name>A0A2X0P054_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C019g09003 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C019g09003</name>
        <name evidence="7" type="ORF">BQ5605_C019G09003</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY24016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P054"/>
    <dbReference type="STRING" id="796604.A0A2X0P054"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000464">
        <property type="entry name" value="Ribosome assembly protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF0">
        <property type="entry name" value="NOTCHLESS PROTEIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="6">
        <location>
            <begin position="32"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="170"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="212"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="255"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="308"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="431"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="473"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="515"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY24016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="546" mass="59832" checksum="5E0246AF41BC54B9" modified="2018-09-12" version="1">MSTQIPPTPKRARLNPTKEANAAAAAGPVATIVCQFRNALDGSLLGPAVSLPADTSREGLELLANTLRGSEQDPVPFAFHLNLPNTTQEENVEDSRIAITTSLHVDLLTKHATKVSTEDVFVIECEPEAVFRVREITRCSSSLDGQFGDCTDLYYYCLLTPMRLGGSLCDSGHASPILCASFSPTGRILATGSGDNTCRLWNLDTETPQSTLKGHTGWLLCVEWDGLERTVATGSMDNSVRLWDPKTGLAIGDALRGHSKWITSLAWEPVHLQVHRAANVAKPRLASSSKDSTVRVWNVKAQRLDFSLGGHTASVNVVRWGGEGVIYTASSDRTVKLWSGKDGKLIRTLSEHAHWVNTMALNTDFILRSGPYDQKAKTPANDEEAQALALARYQKFTSTQPELMITGSDDHTLFLWSPLASDNPKKPLARLTGHQKQVNHVAFSPDGKFIASAGFDNAVKLWDGRTGKFIASLRGHVAAVYRISWSSDSRMLVSASKDSTLKLWDLKTYKIRVDLPGHTDEVYCVDFVADKIASGGRDKKVKIWRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P1E4</accession>
    <name>A0A2X0P1E4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C006g03897 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C006g03897</name>
        <name evidence="4" type="ORF">BQ5605_C006G03897</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY54688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P1E4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="3">
        <location>
            <begin position="379"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="GAG-pre-integrase" evidence="2">
        <location>
            <begin position="485"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY54688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="615" mass="67468" checksum="FFD7A386AFDC8A08" modified="2018-09-12" version="1">MSPNRQHASFDELPPPSTASVHPPGQPPLARAVMSSSSAAPTAEEIKALIQQALDVHGRDNRSSSSSPPDTTTETASVPRVPAATPITFEAVNRLKDEATYPRWHRALKALVPTPIFSYLQTGNFPAEWSIATQDQWKDYVRSVLFNSLHPSIQDVYQEHDTPSQVYITLKERYSPRDAQAYAKLIQRFWSMPQIPLSSKDDFDKHLNHDLDLAREIRQGNLDIEQVLVAARLFCTNFNDGLDPWRETFLQLHQGKDRLPSLEEAMKSMRVAAHNIIDKRPSAYVSNSDKSGTPPGPCPACKTGPLHWLRECTDEDAKKRFFSRPRPNHSKQNANAKPPAQARLAVASDDPGEISETAPSVSFAATSFLSVTSDSPSLLLDSAASHHMVNDSTAFVELHNTPRVQIGGVGGALSSHGTGVIELVASTGNRIRLSNVFFVPGCPANLISVFALINDGITASFTEDGRVSLDRGGKRVCTGSAKSDRLFHLDAHLCTHTALIAARTPKVSLLTLHRRLGHCSLPTLRKPAKSDQVKGIEWTYSDDDCNDFKCDACMASKAHKLPFPMSESHAALPLGLVHSDLLMFPEPSVSGRRYLITFCCCRSISSYVASIDDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P3F4</accession>
    <name>A0A2X0P3F4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g02091 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g02091</name>
        <name evidence="2" type="ORF">BQ5605_C003G02091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY38860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P3F4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY38860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="156" mass="17308" checksum="91B23081034A460D" modified="2018-09-12" version="1">MTSQSSNEHESLGHRIISAMTGHRHHQTKSPSEIASQKRSAKAEHDRLEAQVDAEIQDRERQEARVGVRPFQAPEVVGGRLGLEEIVQQAHHPEQHSNHHQGHPDLYGGTHIPETSLPQMHHETQHTALRPSDPNDPTAMDGAVRNDTSAGDDYAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P5N4</accession>
    <name>A0A2X0P5N4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C001g00246 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C001g00246</name>
        <name evidence="1" type="ORF">BQ5605_C001G00246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY45105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P5N4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY45105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="44" mass="4784" checksum="0CBC26A9B969AF43" modified="2018-09-12" version="1">MIMLGKLGVLDSFSRHRCVDLCLKFSKARSGIPTDACIGDGQKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P5Z4</accession>
    <name>A0A2X0P5Z4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C001g00386 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C001g00386</name>
        <name evidence="1" type="ORF">BQ5605_C001G00386</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY46128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P5Z4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY46128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="82" mass="8876" checksum="981A6473EB66D35C" modified="2018-09-12" version="1">MELGELGDYESAPSGRPHQPLCLTLCANIAINNNVRVIVVIGIVVVVGYQVTGWQVAGDGRIRTAQQLRERMVGCNTPTAWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P6G5</accession>
    <name>A0A2X0P6G5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C005g03463 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C005g03463</name>
        <name evidence="9" type="ORF">BQ5605_C005G03463</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclease type I family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY76043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P6G5"/>
    <dbReference type="STRING" id="796604.A0A2X0P6G5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11010">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.575.10">
        <property type="entry name" value="P1 Nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008947">
        <property type="entry name" value="PLipase_C/P1_nuclease_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003154">
        <property type="entry name" value="S1/P1nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146:SF29">
        <property type="entry name" value="S1_P1 NUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02265">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48537">
        <property type="entry name" value="Phospholipase C/P1 nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015855375" evidence="8">
        <location>
            <begin position="21"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY76043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="349" mass="39287" checksum="64B5FE767FE1711C" modified="2018-09-12" version="1">MRSFLLFLASLSPLTPLVLAWGAVGHETIATIAQIHLHDGAREAVKALLPGLGHLGPIASWPDRIRGLPQYRWSGELHYTSPLGDYPPSTCHFGDEGWKTEHDVLHAIANYTQRLADDHLDVEALKFLVHFVGDVHQPLHLTDRDRGGNSDNVIFEGRRMNLHSLWDGALITKAVREQHNYTQPLPAAQIEQSLRHTIYDPYIRLILWEGVRIWWRDALPSWFLCPKSASPLETQQRRNQIHLETPSSSSPPGIFALGVCPRTWAKETHQTTCARTFPPDYDSQHPIPRELNTKEYYGPIRESNIIEKLLAQGGLRLAATLNAIFADANIQATSSPVNLSWLEDVEAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P769</accession>
    <name>A0A2X0P769_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00846 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00846</name>
        <name evidence="2" type="ORF">BQ5605_C001G00846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY50012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P769"/>
    <dbReference type="STRING" id="796604.A0A2X0P769"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY50012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="59" mass="6102" checksum="CA4488CEFE5B5663" modified="2018-09-12" version="1">MAPPSKVAEKKPASTAGKAPASKAPAGKAPAKKAVKKAPATGGEKKKKKKKKEHYSTYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P7R6</accession>
    <name>A0A2X0P7R6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g03921 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g03921</name>
        <name evidence="2" type="ORF">BQ5605_C006G03921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY54863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P7R6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016001269" evidence="1">
        <location>
            <begin position="25"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY54863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="74" mass="7912" checksum="AAD74B370D06EA64" modified="2018-09-12" version="1">MKRDGVCGWGVVFFFLTGAHKLQSFGLAGTATKRAKGGYKATTASSWVKVKPLRAKSAAQIKTRRAPNADSNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P988</accession>
    <name>A0A2X0P988_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C007g04453 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C007g04453</name>
        <name evidence="1" type="ORF">BQ5605_C007G04453</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY60595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P988"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY60595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="95" mass="10382" checksum="F3A72C2BCEB1AFD0" modified="2018-09-12" version="1">MRCPRFSNKPREIPHSVCKIGSGGNNGIHEGADHRTIRRVVGFIGVDLGRQLEVGLHWRFAGIAIGHAETSQHVNKVLALQEGDPAIIMPDNLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PA14</accession>
    <name>A0A2X0PA14_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C007g04682 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C007g04682</name>
        <name evidence="8" type="ORF">BQ5605_C007G04682</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY62361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PA14"/>
    <dbReference type="STRING" id="796604.A0A2X0PA14"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051857">
        <property type="entry name" value="Asn_synthetase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937:SF1">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Asparagine synthetase" evidence="7">
        <location>
            <begin position="574"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="775"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="869"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="441"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="780"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY62361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1177" mass="129778" checksum="0C856D398B9D73AF" modified="2018-09-12" version="1">MSALVSPHRIFSSWIYKGKSFLTGLGARVMCGIAFALSYRSVKNAETRWALSGPSQAELVLHRSCSTPTAPLIEHDYDNQVKIGHAVRDENATSVSVPSLDCRDEVESEVEDDSAAWWRAVSGAVQPRGPDASGDHHVELEAIKERFNIDMRFHTSVLHMRGDVVTPQPFVEADTGDVLLWNGEVFDGLTVGSHDNDGSRLFHEIQQAGPRALPAILQGIEGPYAFIYFDKAQNTLWSGRDHLGRRSLLLHRPTPSMPRLILASCAPLARPNSDFGEWEEVACDALFSFDLNEVLQSGVPTFVPTPRSFRSDAQAPKNSSFYPYDRLLTIVPTPDQVFDPSSHETQPVQLELQSAILALEAALELSIRQRILNLPPHPDPSSPSPQARIAVLFSGGLDCTTLACLVDRILDEEEGIDLINVAFENPRTIQSMTKLKERQGSGKKKNKNRRKDGEELKMEEGAVDLGNKEISIYDVPDRLTGRASWRELRRLRPKRRWNLVGESYLLGAEVDVPYQEMMEHRSAVMELMRPHCTIMDLSISLAFYFAARGQGHLASSDPNPSSKTTPPQPYHSSARVLLSGLGADELLGGYARHRKAFYTATGGRPLPTSDPSDGSWSHLIQEMQMDLDRLPIRNLGRDDRIISHHGKEARYPFLAAHVIDLCTKLPIWIKCDPRLGEGKGDKRLLRLVAGKLGLGEVAGLKKRAIHFGARTAKMELGSGRDKGEDAVEGMVNNYLDTASLDLIVMRAPPLRPPLGSERARCPLVLSPPPFFAPLLKNPTMRPTPSHSSTLSSRTTNPNEPVQSTDLDALLSRHSASTLSYLSDPYTSYFLPPSIRRAGPSGWRRPVLIHLGTHARTWGVDRVVERFLLGGGGTEGEGEGEGEGREARGRGRSGSGSESGGEQVARSKLGRRGKRQVLSMGAGTDTRYWRMRDKWISAATEGSRTQEGWEEVVNWVEVDFEEASSAKAKIVATKKELKDGLGASLKIEKGGLALSSKAYKLIPGDLRNLTTSLGPHLLSSDPFPTRSEPLLDSTLPTLLLAECVLVYLPADTTTDLLRWFSSTFRQAGGSCISYDPFNFEDAFGKVMIRNLATRNLVLPAASSTPTLESLNARLTENGFAQAESRTIEQIRKEVIPREEIQRVNKLEQIDEVEELNLVLGHYAITIGNVRGDEGVVGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PB51</accession>
    <name>A0A2X0PB51_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C004g02886 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C004g02886</name>
        <name evidence="2" type="ORF">BQ5605_C004G02886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY68419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0PB51"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1083"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1132"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="420"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="598"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="624"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="679"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="701"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="823"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="862"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="938"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1010"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1024"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1038"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1090"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1132"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1175"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1206"/>
            <end position="1215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY68419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1372" mass="145388" checksum="0DBF1D9C37AAE023" modified="2018-09-12" version="1">MYRGDTASDPPPQGSGRSGPLRPSQLQLHLQSSQPPQLSSQQQQPLQQQQQHPQHAQHPQHPQHLQHHPRGAYQIPQPYGSSVAPAGPPGSAPISTGSYATTGGQPQVPVPGGPSMIHPRMYTPPHQGHANHPHHSMQQQQQKQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHHAQQQQQQQLHQQRISSMPAFVSPSTAVPARAQASSSNGIGPPPHGSYGSGDARSLHSSPVMVHPSLQRVAMVNGSQMQLQQQQQQQQHHPLTHLHPAGHSCPNSPSAAAGPSSYATRASPTPAKQQYHQIQHEHQQQFQPPSSPHYASHHQPPQQQQQQPVQQPQQAQPQRLQPGSAAGPQSWGRPVSPVDRRYHDNSYVTERDGRLTATSRSASLVVSPRPPPPAQPPSQPHHPNSHPSSEQAQAQGQQSAPLGSGDLRPIFHSYIFDYLQKSGLHTAAHAFLRDVPTTPIRPLGPGQLHPASNKGKGRMHESDPSGNSPEIDPRTIPQANVRIESPAGFLFEWWTIFYEVFRQRAGPNGALSSRGLVDMSHHAIDVGIRNSSGPPRGSTPVNSQQQSPRRVTAVPPGPQQQQYQQQQQPPAQYQGNFAGQPSPHPSASAAHPTSGRQPPPPQRIIIAPGGSYGPGQGGPRSGSGPNSNAYSAPGGAAPQQHATIHASQASQLPQQRGIMANTMGGPHQTQMQQTQPPGPLQRQMSHRPTPAQDRHPSQSAPAPGGQHAGLEPQGQRPAYPQPSEQQQRFDAHNGAMEMHGSAAVYSGDRQGLINGAQHHPDQPHMSKQQPQQQHQQIAYPGPPQQSAYHSHAQAQSQMENQRQHGPSPLPVGGPSPGHQYPHATAAVASSAELSSQAQALALQQQRIMLANRRSPPTGPGATMQSNAAEFYPSGIGVNSNPPSPAKRFVAAKGGPINGNDPQAQQNQPPLAVNTSSPYANGAQGSYGILARPDRYGGNYEPVGPVPTPEPSSLYPSADEASASFRRMASLPNPNHLNGPSAKTNAASPHAAPSSTPGAQQGNGVNGNSRPSSTTPRLQTVDPTIALQQDISRSQLQAHHWEGQMPAPALRNASTPSASVGGSRTPAATPGANGLVGAPETPSQYVTSPAMLQTPTQTTSGISPHATTSATTPGSIPVALKQSNTTTTKRKREVAKEASAAPKKPRAASAAIAKPPPRSGPNERKRSLSTAPATTPANVALPLTPSPVMRDTSLPVSTPASTGIVATESTATDPTPSGAFVASPEHQSDSSLFFNPATLEASDPISKLGSTTGGGFYTLDDGGFTGSETVGVNGTGTGAGAGAGAMTSDEIDALFATSTNSLGSAVLDQGQFVDYTSFFNGANFDGFESFDLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PCZ0</accession>
    <name>A0A2X0PCZ0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C005g03598 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C005g03598</name>
        <name evidence="7" type="ORF">BQ5605_C005G03598</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PCZ0"/>
    <dbReference type="STRING" id="796604.A0A2X0PCZ0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005914">
        <property type="entry name" value="Acac_CoA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01217">
        <property type="entry name" value="ac_ac_CoA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002937">
        <property type="entry name" value="PRK03584.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921:SF1">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="133"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="578"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY77296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="691" mass="77039" checksum="A609C0ACD44EF1A9" modified="2018-09-12" version="1">MPPSPRTIFYRPTAKEAEATLDSQFRRYVNKKRGLHLGDYWELHAWSLEDLNEFWTDMWDFTGIVGEKEKLLFDSSQPMDRVNPRLIQAKMNYAENTLMAHSNARSKTAKAIISVAEPSVPSSSPKYLESTHLRTMTYEELYQEVRKLAHSLKAMGVVAGDRVVAFSPSNVEVIVMTLAAASLGAVWSSCPSEFGVKAVLERFTQIEPKVLITGDHYRYNGKSIDVIPKLLELLEGLPTVMHVVMVGQLEKDRISKVPFPKNTHGRSWAHYHEVIKAGEGAPAEIQFTRMDAMAPIFVLYSSGTTGKPKAIVHTIGGMVLSQKMTNSCHNNMSADAVFLQFSTLGWMMWNYALSTLMNGCTMIAYDGSPLAPLGILFSLVDEYKCTHLGISPRFLQTLDNNNYLPKEHHSLKSLKVIATAGSVLKAELYDWVRDNVGPKVFINNGTGGTDICNLFVGGVPSLPVYHAEIQAPGLGMDLHALDDNGKPIIDAQGEMCILKPFPNMPLGFWNDEGDKRYRASYFETYKNPICWTQGDWIELHSVTGGCTVFGRSDGVLNPAGVRFGSAELYSVVEEMRDIVEDCIAVGQKLPDGDERVVLFVLPKQGNLTPELRKRINDNVRTQRSTRHVPAVMIHCPKIPYTGNGKRLEIPVKKLVNGAKYESLNLSSAEDPECLKFFINHPELELKVKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PDH7</accession>
    <name>A0A2X0PDH7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C005g03627 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C005g03627</name>
        <name evidence="6" type="ORF">BQ5605_C005G03627</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UFD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PDH7"/>
    <dbReference type="STRING" id="796604.A0A2X0PDH7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.50">
        <property type="entry name" value="Ubiquitin fusion degradation protein UFD1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004854">
        <property type="entry name" value="Ufd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042299">
        <property type="entry name" value="Ufd1-like_Nn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055417">
        <property type="entry name" value="UFD1_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055418">
        <property type="entry name" value="UFD1_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555">
        <property type="entry name" value="UBIQUITIN FUSION DEGRADATON PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555:SF13">
        <property type="entry name" value="UBIQUITIN RECOGNITION FACTOR IN ER-ASSOCIATED DEGRADATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03152">
        <property type="entry name" value="UFD1_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24842">
        <property type="entry name" value="UFD1_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 1" evidence="4">
        <location>
            <begin position="129"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 2" evidence="5">
        <location>
            <begin position="260"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="499"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="542"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY77399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="563" mass="59833" checksum="33B5C449C7C54B29" modified="2018-09-12" version="1">MSSDQEAQDLPSDDDAYEDYDPNDFLDDDQDPPIVAPVAPVIPTTAPAASASRVTRSSNAAYQSPPQPHHDDDDDDDGEEDEDGDNGGYGLFPTFGQAARQAMGRFINPNAFQAGFGGHAFARPPASAFRRQYRAYSTAILEVQRGRSYGGGRSNLMYGGKITMPPSALEEITQLDIELPITFEITNPAQPDLTTHVGVLEFIADEGTVNLPQWVSTCTPNSYVCSASESNKCHHPRQIMDQLRLNEGDPIRIWGGRYPKGKMIKIQPQSTDFLEVSDPKAVLEQALRHFSCLSAGDIIEIGYQSLTFRLLIMEITPPGPAISIIDTDVEVDFAAPVGYVEPEYVPRGAIAGPTMKDKYTIDTKGVQDVDARGSGSSTPASRGAGAAVGADGAVHSWEAFKGSGNSLSGKRIKGKGVKAKKIEAVDENSMIFRTDQPRMVTADTQIGERQVPAALNLPPGNLFFGFEPRPPPGSEEDIADNLKAEAESAATPVPFAGVGSGSTLSGRARNSAALPQGAPMPPPTMALPSLATSVPAAGGQLKSFSGSGNTLSGKKPIETIEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PE15</accession>
    <name>A0A2X0PE15_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C008g05189 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C008g05189</name>
        <name evidence="2" type="ORF">BQ5605_C008G05189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PE15"/>
    <dbReference type="STRING" id="796604.A0A2X0PE15"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="1">
        <location>
            <begin position="358"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY79656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="510" mass="56510" checksum="28753431513B2387" modified="2018-09-12" version="1">MRGYTQGLRLLTPYPPLMHLTADHDDRVVPLHSLKLIKELQNSIFNNPYPLPFESIPNQAGQVEESDRGSLFARYNGHNWNLLEGRNNGLKFQIALFDRGRQARVRKRPEAADLGPSVSERINWLPVPSTPHAPLDTNTMPIKLQTGLGERLTSSDIEAKAFAELPIIDMTRLTSSKLEDRQALALEAAIESGFFYISNHGVPQSILDEAFAQGKQFFAQPTEKKMEVDLHKGTSFKGYAPLMGEAVDPASRGDVHESFDMGSDSQTFHQGTEKKEGVISGNLWPSEKDLPGFKPALEATWDHIMALGKKLFPLFALALNLSVQAARSSAILCSGATIADSATIHREENYFDDKLTNPGSVMRILHYPPQTGPIDMTAIGIGSHSDYETFTLLVQHGDVSALQVLNSAGDWVQAPPIPGTIVVNIADQLQRWTNGVFKSTIHRAINRTGKDRMSLPFFFGVDYDVLIEVLPSCITEDRPAKYEPVKAGEWVEQRLKETYIKVDPVTGIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PEK0</accession>
    <name>A0A2X0PEK0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C008g05399 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C008g05399</name>
        <name evidence="1" type="ORF">BQ5605_C008G05399</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY80479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PEK0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY80479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="60" mass="6841" checksum="589089E69D48B4D3" modified="2018-09-12" version="1">MCPPCPNRHSNLSGQLELQLDDTYNVDDPISLTPCLNATRYASRYISIRPIRLRPRGANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PGP3</accession>
    <name>A0A2X0PGP3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C027g10359 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C027g10359</name>
        <name evidence="5" type="ORF">BQ5605_C027G10359</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PGP3"/>
    <dbReference type="STRING" id="796604.A0A2X0PGP3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
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        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF3">
        <property type="entry name" value="FI21236P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="59"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="188"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="323"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="407"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="420"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="446"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGZ28512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="456" mass="48433" checksum="B099DB47A4F2597A" modified="2018-09-12" version="1">MEVDRAVDPPKREFRSSRYNPDRDHGSRATGSTPYDPVRKAAARQTAAIEASKHSKKENRVYITNLSFNVKWNDLKDFMREAGNVVFSEIMTLPNGMSKGCGVVEFSRPEEAQRAISQLNEQPLLGRPVYVREDREEEARYGSAAVSGPRPGYTGPGALTAPTRGGFSAGVGRGGGFASSAPAPGQGRHLFIQGLPANAGWQELKDLFRAAGQIIRADVKTAPDGTPTGTGTVVFETSQDAQNAIAMYNGYEIDGAILEVREDRFPTGGGGGGFVPRGGFAGGRGGFRGGFNGGFGAPPPHLPFAPPGFMQGGFKPLVATPNKQIFVRNLPWSTADEDLVELFQTTGTVEEAAMLIDEATGRAKGSGVVQFATIEEAQTAIAQFQGYTYGGRPLQIEFNARYKNFQGSGVPAGAPTGPRGHQEADQERGNNGEYGDGSADASHGNGEGREPLPEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PJ25</accession>
    <name>A0A2X0PJ25_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C030g10864 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C030g10864</name>
        <name evidence="2" type="ORF">BQ5605_C030G10864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000069">
        <property type="protein sequence ID" value="SGZ09337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PJ25"/>
    <dbReference type="STRING" id="796604.A0A2X0PJ25"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="271"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="477"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ09337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="761" mass="82106" checksum="93417FD6D2A74FA1" modified="2018-09-12" version="1">MPATSLNLPMRHLFSCTPHTWFEPPPPGNAPDYSTAPRLQANAGTAFDCAARLGGLRWGDYSSPGDRIVDSFLSLLDLHPSLLELFEAKIAVIEAMGSTRAGRRARITEDEVQNAFAILADGLGGATGELLDHYASITEDDFTPTTSGYWVKLRSVQGLSYRTRGDAILQIGRGVEDSAVVVSSIAIEFKRGPVHYTAAKGPPPSGTNSAIPVLDHASPVPLQNLETQVSVGPDAIATKAIIQCASQACRFFLLFSVPFFQTGELVEHQPSDAARASDAAGSTASASTSTAPMPGTPHSSTPTPPTTTEASTPPAVRRQYSLLLQELVRWVERYPGTSLQPAETLGVDLPARSFIVSFIALAFTAVMKVPEPGKDRVKELLDANPNTSNQSRPRAVSDSDREDPSYEPANKAPKTSAIGPGTRSSRRLVGDPPPTQAKGSNRPVTPPVSEEAGSDLSGALTPEALCFSSPPASTDRSPTTSPASGSVPSSKSITIAHDRNFVIQASLSNAHWSMMSYTGTSRVNLVEIDFDIVSSDRSDSPLSSLLPSNPSPATDFIRSLHLSDAVLQWLTEDPKDELEDDRIPLELLGYFEAAADLRLEKQVGTGSTADGYLANVVRVNPRWSSPANREVPLVGHPAPNTGYFLKLVTCNHVGSVVRETLFYQHVFPHLPDGLQKHLPQYHGTYRGINGNGYAMVLENVGTHMNYSEFYERSGQWQEIEKAFVELGIVHNDIRQGNVLVRPDDGGFCFVDWGRSYLKLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PJG5</accession>
    <name>A0A2X0PJG5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C068g12850 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C068g12850</name>
        <name evidence="25" type="ORF">BQ5605_C068G12850</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000130">
        <property type="protein sequence ID" value="SGZ35039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="526"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="822"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1413"/>
            <end position="1479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGZ35039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1479" mass="162227" checksum="1F3B836962F2DD46" modified="2018-09-12" version="1">MDDTSPPLATGVHPTFPADQLAALTSLLSGLTAAASGTVTTTTSSSTTRPAFPKHARLDGPKMFANWTRQLRLCLADDIRSYVLDGIVPVDWTPSQRSARDVVARELLANSIDSAEVSAVLDAIPTADLTAPKIYLTLKSWYAPDDATRTLELFSRLWSFRPMPGTVGEFDGWIMEFKAIAQEIIDTKTTINDVLATLLLAIAHPSLESFKASFTDEQRTQRSLPAIDSLADRMRVQLRSTNVPSTQSALLASSSSRPTRPKCLACHSPSHRVAECPVRAKHPPPGPCRSCKQNHWSFDCKKALENGKKADTANSTANSQHHVGCIATGFLARRRQLRTNSFVVDSGATSHMVSDKSLFTTYRHIAPTKIGGIAGGINAIGTGNIAFVAASGHPITLTGVLHTPGLFVNLLSVSRLCDTDDVRVAFTKHGIDIDKNGHNIAEGTRLDEGLYLLDADHSKCQHIALLSRSQSSVPLLTLHRCLGHLAPSSIQKMVAAGLLEGLRAGYSDEEVEKFVCNACLSAKGHRLPFPDSDSHSSKRLGLVHSDVLSLPERSLTGKRYLVTFLDDYSRKLWAYAIGHKSEVFSVFKTWLAEVELETGATLKVLRTDNGGEYCSRAFTDFCKVRGTRRQYSIPRTPQQNGRAERVNRSIVEGILALLADAHLPKTFWEEAAAYFVYCKNLVQHSALDKATPNSVWQGGRTTASALHPFGCAAWLTVAPELRSKLDPKAVRVLFTGYDLASKAFRFYDTTTKKVTLGRNATFVDTEFPGLCGDSAEPDDDTHFASAPFADPQTTVKSWTPLYSADPLDLIGSQPQAALDPMDTQPPDFSTYREPASAEESPDELDLIGRHSRDESPDEIDFLTRHHRAFIATDDDTSDTEAIEPVKSITSDPQTWREAMSGDKREVWAKAAADEFNSMRDNFKVFTIDDRSTVPAGATIVSSKFVWKTKRNALGEITGHKARLVAQGNRQRDGIDFTETFAPVARFSSIRSLLALAATNGLHVHQADIDKAYLHGDLDHDIWMTAPRGFDLPGDKVLRLRRSIYGLKQAGRIWNRHIDASLRDLGYTATGTDHCVYSRLDDRQRPHYIALYVDDLLMISPDLAEIERVISGLEQRYGVKRLGPAEYILGIQIRRLDDGSIALSQERYIMDVLARFHFDTTTRGTTVPMTPGLSLTAIPGQATERIRSWYLQAIGSLLYISLGTRPDIAFAVSYLARFANNPGHRHWIAVKHIFRYLRATYRDELVYARGEARITGVVGYSDANWGACVDTSISTMGYVFYIAGSAVSWSSKRQSRVADSTTDAEYLALSHAGKEGIYLSQLLEELHVQPVAPAHIFTDNEAAAAVARDPVRVTGTRHIRLREHFVRDMVNRGDISLSHVGTSDMVADIFTKALGPKVFSTHCYALGLRTRHPRLGSASHSRGGGCKESTLSSTEAPRSSRAPASPPPCGGDLGARDCLSEQAPADSGARPLGRPLEVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PKT2</accession>
    <name>A0A2X0PKT2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein transport protein Sec61 subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C023g09659</name>
        <name evidence="13" type="ORF">BQ5605_C023G09659</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Necessary for protein translocation in the endoplasmic reticulum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SEC61-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ23911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PKT2"/>
    <dbReference type="STRING" id="796604.A0A2X0PKT2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005784">
        <property type="term" value="C:Sec61 translocon complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030671">
        <property type="entry name" value="Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016482">
        <property type="entry name" value="SecG/Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13509">
        <property type="entry name" value="SEC61 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03911">
        <property type="entry name" value="Sec61_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006398">
        <property type="entry name" value="Sec61_beta_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGZ23911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="96" mass="10271" checksum="E78385B9E4676556" modified="2018-09-12" version="1">MSDASKSPVKVPGATGPQLRRRAAALSPTKKDADAPQSLRAAGAGGSSSTMMKLYTQDENPGLKVDPVIVLSLAVVFIFSVVFLHLFTKFVRYFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PN35</accession>
    <name>A0A2X0PN35_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C026g10252 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C026g10252</name>
        <name evidence="2" type="ORF">BQ5605_C026G10252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ28018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PN35"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ28018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="309" mass="34054" checksum="4F356B3082EA8704" modified="2018-09-12" version="1">MHKRTWSLDIKNEFPYTPKAEQQEDSYSCGPATINAVETEVLGIGSFNAARAHMSRLCQFCRLSSLVGAVEDPKEIESIVATGAKSKANTSAESGKAATIKPTNQQVASSSKNPPTSRLQTTFTKASKPTKAQELTPEEHTTWARDHPPLFRRLAEKVEDLCPGSNVDVNNPKYVRCGRCYVLVPMAALLCKAQFELHLGNKKCVNLQPISNFFRPIACGSTAPSPSLGPCPGLTSEMAIHCLSSTAAQGGGAPPRRTLYLRLYPKIGKRPMTELERKEVDKLEANEWKWRNDHRAPRIISVNCRKYSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PP41</accession>
    <name>A0A2X0PP41_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C042g12019</name>
        <name evidence="8" type="ORF">BQ5605_C042G12019</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000116">
        <property type="protein sequence ID" value="SGZ31849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PP41"/>
    <dbReference type="STRING" id="796604.A0A2X0PP41"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03751">
        <property type="entry name" value="proteasome_alpha_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000007">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGZ31849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="261" mass="28650" checksum="4CC52A318E494C9C" modified="2018-09-12" version="1">MSSIGTGYDLSSSTYSPDGRIFQVEYANKAVENSGTAIGLRCKDGVVLAVEKLVTSKLLVPGANKRIATVDSHAGVATAGLLADGRHIANRARDECEDYRNNYNTPISTKMLSERLSLYFQAYTLYSSVRPFALSAIVAGWDAPDGIAEKKAEGLPKLFCIEPSGVYWGYRGCAIGKGRQLARTEIEKLKLEELTVEEALIDAARIIHQVHDEAKDKDFELELSWISPASGWRHQAVPRDLADAAEKKAKEILDAENEMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PPK4</accession>
    <name>A0A2X0PPK4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sn-1-specific diacylglycerol lipase</fullName>
            <ecNumber evidence="14">3.1.1.116</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">BQ5605_C041g11985</name>
        <name evidence="17" type="ORF">BQ5605_C041G11985</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33276"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="14"/>
    <dbReference type="EMBL" id="FQNC01000119">
        <property type="protein sequence ID" value="SGZ33704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PPK4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046340">
        <property type="term" value="P:diacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052214">
        <property type="entry name" value="DAG_Lipase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792:SF8">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="16">
        <location>
            <begin position="572"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="382"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="388"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="442"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="SGZ33704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="855" mass="92142" checksum="F99B54C60F0E7983" modified="2018-09-12" version="1">MSDTTTTPAAMVSGADSLPTSQALTTVNGNAQRDDDLLMSPSCTVEDDRETAQDQDDSKAAVLATPAFLKGLQPPPLPLWAVPHTTTALTASRLSLLSARSFASTGFAIARTSTSLGFGAIKVAVAGIGVLLDHSLGLAGNAPMMDGSGPLAQTGIAAIAAAEKLALLGINIGSGITNLALGGATSTIAFLEDVYGNDEALRTLEAFTRLVKDEWNTSLPTDPYQEGGLSHWSTIQVAKAAATWAALQSVTGELDGRRWAMHLDELDWGKERIPPPQDGTGGVLWEITDDQLFESGAEIIEATINQDDRSSQTGSEATHSEEHARQQLRRFASMCLGSYGSAGVLFFGVKLPSIDATIAPDASSTTVHSLTPDNLSALARQQAEEDLERTLRPRQHDAAPPEEEQSEAAQLGDLAAGWALPAEAVSAVEAVEFPPGSTVDQSEATSETETTSALQAEDWGLKSEGALPRAKPRTNAAKLSSRYDYWGLLTGKHDEAILHSVAGVAPDATLEEACGSSDEDDDDMTDVRPEVLSQRRNARVAEREARKRRDMRGRRPPRFFILTDHPNHTITVLVRGTTTIDDIATDLACESSIFDETEYWDDASPPQSSRLAPYTVHSGMYEIALAMGRKDGAMHRVVDKALRRNPGYGLQLAGHSLGSGCATLLGLMWANPDSATISSKSGLPPGRSVQVFGFATPCVTDAALSMRCRKLVHSFIHSYDVVPRFSLGHMRDIRSAAAWLCYANSDHPGESCDNILSRIVAYKRGKLDDDPALKKEEEDWFTSIRTSLEANQNYSTLCPPGDVLWLTKPDDLILPSDATRTVHPGPRLFRVKRPDIIFKQMIFTRNMLSSHLPHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PQA5</accession>
    <name>A0A2X0PQA5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C041g11934 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C041g11934</name>
        <name evidence="2" type="ORF">BQ5605_C041G11934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000119">
        <property type="protein sequence ID" value="SGZ33136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PQA5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ33136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="160" mass="17181" checksum="1A5C3B3649148E63" modified="2018-09-12" version="1">MLSGDCLIPFVANTGHPITLRGVLHAPGLHVNLLSVSRLCDTNRVRLAFTSDSIDITKDGQAIAHGTRINDGLYLLDADHTKCQQLAFLSRSESTVPLLTLHRCLGHLAPSSIQKMIAAGLLDGFGAGYSDKDVKSPLSARQRRLGRRAHPLARPLAVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LNJ2</accession>
    <name>A0A2X0LNJ2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C011g06256 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C011g06256</name>
        <name evidence="1" type="ORF">BQ5605_C011G06256</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY11740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LNJ2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY11740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="374" mass="40374" checksum="217814E93168FCCF" modified="2018-09-12" version="1">MSLPPLEKDNPIPCSLKRTVNAIKLVDAALSAEILTEDARRDLITKLSLEAGLTRNHPSGDIKLVFWLGQLRAIPTDTPLAINNLSELHPIIAQALVSGDGYYCKRATSAALTTPNAPLAEGAFHVAQAAPAAAVVPGPPSIVTIEGVGKVPSYHLNALPWGMDGIVIVEKCLFVFSTQFDATQFPVGCLAQLVTSPRGMLVSTQDIIDNEEQNWADVKSERMEQLMRLAGSPAPAPAPARPPIHRAQTAPLQAHLAPPTQQYPSVYQPTSPTIHVPTAEPANDKDRRYRLECLNAACAAPAYSADPKVIGRLSQEASWDKARMCKLYGLQLASGVSLIIYKSAEIWNTSTHLASGVSPMRRELKKLGARNLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LPW0</accession>
    <name>A0A2X0LPW0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C010g05870 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C010g05870</name>
        <name evidence="2" type="ORF">BQ5605_C010G05870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LPW0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY13456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="122" mass="13047" checksum="C66900382D3604A6" modified="2018-09-12" version="1">MISIRVRNYLKGSSGANTYDPKTGLGKGAPGFTTAGTRKVALPAHLVARIKSGEDVSAEEVTEALELEEERLRRKAQDALEAEQRAKKGIKTMKVPESVDSSWLPPGSTVVGGSGGARRRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LQ53</accession>
    <name>A0A2X0LQ53_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C010g05970 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C010g05970</name>
        <name evidence="5" type="ORF">BQ5605_C010G05970</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LQ53"/>
    <dbReference type="STRING" id="796604.A0A2X0LQ53"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_uL16_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_uL16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220:SF13">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY13770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="326" mass="34842" checksum="E9AC331E519031A2" modified="2018-09-12" version="1">MASFLRPTTFLANLSRMTLGPAATSSSSSSTSRAMMLLSSSSLSLTSSSSLSLSPSSSSYAHPLPLFQPRMQARHKALMPRRTKYRKAHKGRLPIALGGSTKATTLEWGDFGLRVNEPCRLSAKHLESAEAALKRGLKTVRGSKVYLRVFPDIPVCIKGNETRMGKGKGTFEFWACRLVEHFIPFQDLLFNSVLKFPSRSGTTRAGVGRVIFEVGGPNLRPEIAHAGTLKRIGIGQPASAKLTTDLFSPNAVMKLAAAKLPVTTEVIDKTSPPRVGYTTIDTIVKTPKIIKKGELDALASLGVGATMTSADVKGDVAAAVEDTVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LR51</accession>
    <name>A0A2X0LR51_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C013g07192 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C013g07192</name>
        <name evidence="1" type="ORF">BQ5605_C013G07192</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY14978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LR51"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY14978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="64" mass="7186" checksum="92402A99686A9544" modified="2018-09-12" version="1">MRERSAPSAIWHRRRIECQPRATEILQGIMRPAPVIEAGSSSKKRRLSKVITLEDDEDEGGGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LR62</accession>
    <name>A0A2X0LR62_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Eukaryotic translation initiation factor 3 subunit K</fullName>
            <shortName evidence="1">eIF3k</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">eIF-3 p25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C013g07115</name>
        <name evidence="4" type="ORF">BQ5605_C013G07115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-3 subunit K family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY14821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LR62"/>
    <dbReference type="STRING" id="796604.A0A2X0LR62"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.250">
        <property type="entry name" value="ARM repeat, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03010">
        <property type="entry name" value="eIF3k"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009374">
        <property type="entry name" value="eIF3k"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016020">
        <property type="entry name" value="Transl_init_fac_sub12_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13022">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13022:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSN8/PSMD8/EIF3K" evidence="3">
        <location>
            <begin position="73"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY14821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="262" mass="29374" checksum="E99561E1FAF36E5D" modified="2018-09-12" version="1">MTLEVVPPSRPSHIATLINGVDRYNPSNCHLLEEYVQQQLSNSSYDLLSNLALLKLYQFNPSLLSPSATLSILFLCLVHRPFDPDFSLAWSLLGDSFVVGASLPPAPLDSDDEEDELPKAAAPQGEREAAYRFKLLSQYLQARRFKLFWSSIRGNLTEGDKATEVNKILGEMKEAAEGWERVTREQIAIELEQSFRGLDQKTTQVFLGLQDGSDELKAIKEQRGWTDQGKDLKFPKNDGNSPTSTVTNEKITIDRESRAESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LT90</accession>
    <name>A0A2X0LT90_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">V-type proton ATPase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C015g07950</name>
        <name evidence="9" type="ORF">BQ5605_C015G07950</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6 8">Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector. Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the V-ATPase V0D/AC39 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY18004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LT90"/>
    <dbReference type="STRING" id="796604.A0A2X0LT90"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.50:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1690.10:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1690.10:FF:000003">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.50">
        <property type="entry name" value="ATP synthase (C/AC39) subunit, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1690.10">
        <property type="entry name" value="V-type ATP synthase subunit C domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_csu/dsu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016727">
        <property type="entry name" value="ATPase_V0-cplx_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035067">
        <property type="entry name" value="V-type_ATPase_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_csu/dsu_dom_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11028">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018497">
        <property type="entry name" value="V-ATP_synth_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="V-type ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00059209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR018497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY18004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="356" mass="40025" checksum="AB27E5A30E2D38C6" modified="2018-09-12" version="1">MEALFFNSHSGYLEGIIRGFKAGLLTQTHYSNLTQCETLDDFRMQLSATDYGNFLANETPPISTSTIAEKATQRLVEEFNYIKSNAVAPLTTFLDYMTYAYMIDNVVLLISGTLHERDTHDLLERCHPLGVFDTMPALCVATNVEELYSTVMVETPLAPYFRNCLSAQDLDELNIEIVRNTLYKAYLEDFHSFILSLGSPTSDIMSPILSFEADRRSLNITINSFGTSLTKDQRAKLFPSLGRLYPEGTTTLAKADDVDQVKTVLDSVVEYRSFLDSTQSGAGGNSGASDGAASLEDHFFQHEVGLNKLAFMQQFQYGLFYSFFKLKEQEIRSLTWIAECIAQNAKDRINDYIPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LTE8</accession>
    <name>A0A2X0LTE8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Alkaline phosphatase</fullName>
            <ecNumber evidence="2 11">3.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C010g05928</name>
        <name evidence="14" type="ORF">BQ5605_C010G05928</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="2 11"/>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LTE8"/>
    <dbReference type="STRING" id="796604.A0A2X0LTE8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.140">
        <property type="entry name" value="Alkaline phosphatase, crown domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018299">
        <property type="entry name" value="Alkaline_phosphatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042085">
        <property type="entry name" value="Ap_crown"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596:SF5">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00123">
        <property type="entry name" value="ALKALINE_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="37"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="620"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="629"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="8">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="566"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGY13647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="640" mass="68694" checksum="469C25EE8272C253" modified="2018-09-12" version="1">MTVDTSKDDIQFVLDELASFVAQENASVDSLPTEQLLHGSDDADHELGSTEASHYDEKLPEPVTSRGASGRSRIIVPTRADIAARVLNPRPGQGASRWLIVVAGLLSLLLIAWTATALLTLGTRFGHSGPKMNVILMISDGMGPASASMARTYLQHLSDAIVTSSSSSAAPSNALNTSIWAALAAGFKTPRYGMTPLDEILVGSSRTRSSSSLITDSAAGATAFACAIKTYNGAIGVEPSQQEPCGTVLEAAKRQGFATGLVTTSRITHATPASFYAHVVDRDLESEIAAFLVGKGPQGQVVDIALGGGMCFMRPNSTGTASCRTDGQDMLAMAQQNGYTVLDGIKALRNWHDESNHDGSPVLGLFSHDHMEYEIDRQQIDVLADEQPSLKEMTTHALRYLANQDTKGFFLMIEGARIDMAAHNNDPVGHVSDMLAYLETVQFVKEWVKQANDDTPTLLISISDHETGGLALARQLGTAYPEYAWYPDALTNATHSSSYLGSLLAKTASPTRQFVRELLEQVGVSDATEDEVAAVYAVQTDAYRANRLLADAISRRAQVGWSTAGHSGVDVNLYAYGHNASGIAGNHENTDIGDHIAHVMGLNLEVVTLELRRNADRWHSTSLGQSPTRRTEVGHYHGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LU57</accession>
    <name>A0A2X0LU57_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA topoisomerase I</fullName>
            <ecNumber evidence="7">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA topoisomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C010g05899</name>
        <name evidence="11" type="ORF">BQ5605_C010G05899</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the type IB topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="7"/>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LU57"/>
    <dbReference type="STRING" id="796604.A0A2X0LU57"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00659">
        <property type="entry name" value="Topo_IB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00660">
        <property type="entry name" value="Topoisomer_IB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.41:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.15.10:FF:000002">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.11.10">
        <property type="entry name" value="DNA Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.15.10">
        <property type="entry name" value="Topoisomerase I, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.41">
        <property type="entry name" value="Yeast DNA topoisomerase - domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013034">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013030">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001631">
        <property type="entry name" value="TopoI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025834">
        <property type="entry name" value="TopoI_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014711">
        <property type="entry name" value="TopoI_cat_a-hlx-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014727">
        <property type="entry name" value="TopoI_cat_a/b-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013500">
        <property type="entry name" value="TopoI_cat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008336">
        <property type="entry name" value="TopoI_DNA-bd_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036202">
        <property type="entry name" value="TopoI_DNA-bd_euk_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013499">
        <property type="entry name" value="TopoI_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018521">
        <property type="entry name" value="TopoIB_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051062">
        <property type="entry name" value="Topoisomerase_IB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290:SF3">
        <property type="entry name" value="DNA TOPOISOMERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290">
        <property type="entry name" value="DNA TOPOISOMERASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14370">
        <property type="entry name" value="Topo_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01028">
        <property type="entry name" value="Topoisom_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02919">
        <property type="entry name" value="Topoisom_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00416">
        <property type="entry name" value="EUTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00435">
        <property type="entry name" value="TOPEUc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56741">
        <property type="entry name" value="Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00176">
        <property type="entry name" value="TOPO_IB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52038">
        <property type="entry name" value="TOPO_IB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="DNA topoisomerase I eukaryotic-type" evidence="10">
        <location>
            <begin position="488"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="88"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="839"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="252"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="313"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="6">
        <location>
            <position position="936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY13579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="977" mass="109495" checksum="C78BC517CD680F47" modified="2018-09-12" version="1">MTDAAAAPKYKKRVIQESSSDESGDEDDVPLNKRPRPELSSNGHHAAIGNGSYAPVAPAPVVEMKDGAKTSASASTATMSDLLFAAAAAASADSSTNTDKKISVFTTGDSDDDDDDDGEDDAPLASKQKKQAMTTTTKKINNGYQSDSDSESDHAALEAQVKKHVAKEAMVSKQVEKLSKRVDREEADDDNSSEDEKPLATKAKVKAKSATTKKAGAPRASSSKSKASKRKNDASDDEEQDDDEEDSDQKPMSKKTKKAPAKKGTKSAPTSKKATPVQKGSAASKVDKKLKKEDSITPAKLALNKGKGKDKYDDDEDVKTENGDGEEGAYKWWEDQSNDGTTKWKTLEHNGVMFPPEYEPHGVKMKYEGKPVDLPPEAEEVASFFAAILETDYVKNPVFVKNFFDSWLGVLKAFPPRDGTKITTFEKCDFTPIFAHLETAKAKKKEMTATQKKEAKAIRDITEEPYKTCLLDGRKEKVGNFRIEPPALFRGRGEHPKTGLLKVSNLSRHHSVKTRVRPEQITINIGKDAKVPTPPAGHHWKSVVHDDTVTWLATWKENVNGNVKYVFLAAGSSLKGQSDLKKFEKARALKDHVARIRRDYTADLKDKEMVVRQRATAIYLIDRFALRNGNEKGEDEADTVGCCSLRFEHVTLTPPTKVTFDFLGKDSIRYVNEVEVDEQVFKNLKIFKKEPKTIGDLLFDRLSCLFEPSQTSTVNKYLNSYMDGLTAKVFRTYNASYTFQEQLKDTPADGSIADKILAYNRANRLVAVLCNHQRSVSKGHGQMMDRMTDKIRALKYQRKKLRCALLNSPEKKKYKQYKEDESDIEDDWIISHEEQLVVLEREKIKKRFEKENLKRAEADEKPLPASELKQRLEAADELEKTLKAERKKGWKETRYSDEKLIAQIEKMDERILVAKTAATDRDEGKEVSLGTSKINYIDSRITIAWCKKHDVPLNKVFSKTLVDKFTWALDTPADFVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LUG6</accession>
    <name>A0A2X0LUG6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C017g08357</name>
        <name evidence="5" type="ORF">BQ5605_C017G08357</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY19866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LUG6"/>
    <dbReference type="STRING" id="796604.A0A2X0LUG6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Helitron helicase-like" evidence="4">
        <location>
            <begin position="168"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="764"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY19866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="861" mass="97601" checksum="BCB215595107F656" modified="2018-09-12" version="1">MLRLHNSRVKPFLTAQEFMNSEASHITYNLPTQEELRLESNLVPFKEVAVILPGDNTEYRSSRREIVVRLRHPPNNDSSRIQLIHNGHPALMALTYPLLLPYGEDWYHDRISLSQNAIAAEAARRVQDENGVLQRTTYNTNANPQTGTAGSKHVTQSQFNTYYFHIRPHNISYPTLFLGGRLFQKFVADAWAMTEQERLYWMRANQKKLRAEEYLSLQASLAEGLDPAQIGKRVILPSSHTGSPRQMIQLYQDAMAIVRVFRAPDIFITMTCNPAWSEIVNALLPGQTASDRPDIVRRVFHGKLKALLAVLGVGCAPGVFGKVIAYVYVVKFQKRGLPHAHILLIMDPEDKLRTNNNYDKIVTAEIPDRDKFPALFETITNSMLHRRCNRPCNHTCHDKHGKCTKQFPKRLQPRTTSKDGVQEEVYTDANVVPTNPFLASKYNCHVNVEIASGVAAIKYLYKYVYKGHDRTSFTIDEPGAQDEINNFLDARYVCAPEAIHRIFQFGMHDRDPAVARLALHLPNEQQVRFDPDHGAPNLSAPPETTLTTFIKLCAKTPPDFNAQGLLYANVPTQFRIFFCGPEGGERYYLRLLLLKVPSPTTFAHLRTFNNVEFRTFQEACVERGLLHDDVEADRCLTEAAIFRTGHELRHLFAMLLTANDGVTNAAQLWTRHYDNLTQDVEYHLRNQWQQMMITPEHVANWGLLQLNNILQRLNSSLADHGLPLPTIHFDDEAATNHLILEESATLAELHEMDALWRKNIESCNTEQRIVVETVLDSILNNRGKVFFIDAPGGTGNTFLEITILAQIRSEGKYALVVASSGIAALLLSKGRTAHSRFKIPIDIFDESTCNVPKQGQLAELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LUR8</accession>
    <name>A0A2X0LUR8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutathione hydrolase</fullName>
            <ecNumber evidence="8">2.3.2.2</ecNumber>
            <ecNumber evidence="8">3.4.19.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Gamma-glutamyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Gamma-glutamyltranspeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C010g06047</name>
        <name evidence="11" type="ORF">BQ5605_C010G06047</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 8">
            <text>an N-terminal (5-L-glutamyl)-[peptide] + an alpha-amino acid = 5-L-glutamyl amino acid + an N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Sulfur metabolism; glutathione metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-glutamyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.2" evidence="8"/>
    <dbReference type="EC" id="3.4.19.13" evidence="8"/>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LUR8"/>
    <dbReference type="STRING" id="796604.A0A2X0LUR8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.130:FF:000001">
        <property type="entry name" value="Gamma-glutamyltransferase 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.40:FF:000001">
        <property type="entry name" value="Gamma-glutamyltranspeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF9">
        <property type="entry name" value="RE13973P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="116"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="18"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="516"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="534"/>
            <end position="536"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="558"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="586"/>
            <end position="587"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="609"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY14062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="706" mass="75582" checksum="AB00371058C2BF99" modified="2018-09-12" version="1">MTDLEQGTGGLSTTRPPRVNSLASSSNSPARRLRASSSVSASGSGSAPHAHEGTPLLSGAPLAQRPSYRKRALSKSIVVESNSNRYWTRVAAGGLGLVLLVTGLVLIILRSEGKLGGSRGDEGDSDGGPNDTPDYSRLPPAKPGLRNPNYLVSGRNGAVATEVDICSNIGVDVLKENGTATDAAIASAICIGVTNMFSAGIGGGGFMVIRPSTSHANFNPRCTEPIAIDFRETAPSGSSATMFSPRPDDPSFDAARASKIGGLAVGVPGELRGLEAAYERCGGGVTWERLFAPSVELARKSKVGRELARRLNAAPFGGASMGAWMLEEEDWRAIFAPGGELLKEGEILRREAYAETLETIGQQGAGVFYEGEFAESMVASVRAAGGILTVDDMRSYSAIVLPARQETYRNRTYYTGHYPSGGAIITHLLNILEGFPKYIDEGRTGLSTHRFVEALKFAFGARTEVGDPAYIKNSHRLSEIPTREYADRVRVNITDERTHTLEHYHPHFDIKEDHGTTHLSTVDRWGSSVSLTSTVNLIFGSRVMDKKTGVIMNDEMDDFATPGIQDAFGLRPSPFNYPAPGKRPLSSTAPMIMDSPDGEVWLSLGGSGGSRIFGAVAQVLLNLDFGYDLGNAVEQSRVHDQLSPAYVSIESGFREDLIEALKERGHNTTVFDVNLGIAEVQAVMRDSNGRFFATSDSRKNGIPAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LVS5</accession>
    <name>A0A2X0LVS5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C016g08228 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C016g08228</name>
        <name evidence="2" type="ORF">BQ5605_C016G08228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY21365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LVS5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015995700" evidence="1">
        <location>
            <begin position="17"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY21365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="151" mass="16354" checksum="B32FA1B4A96A6B11" modified="2018-09-12" version="1">MFLLATLAAIPSLTVSFLSAQAFADFPFCLSCLLAIFFNLFSSSRIFSPSARRPAFSHVSFSCTFSLCSSVKVASFSLRFSRMAKAVFASLGRSWRFFLLELSLCTFEEVEPAIVVACATASCELVKSRLEKVKASAGGRSTAEEVEATKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LWR9</accession>
    <name>A0A2X0LWR9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Conserved oligomeric Golgi complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C018g08693</name>
        <name evidence="8" type="ORF">BQ5605_C018G08693</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY26040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LWR9"/>
    <dbReference type="STRING" id="796604.A0A2X0LWR9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019465">
        <property type="entry name" value="Cog5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048485">
        <property type="entry name" value="COG5_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049176">
        <property type="entry name" value="COG5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228:SF3">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20649">
        <property type="entry name" value="COG5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10392">
        <property type="entry name" value="COG5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 5 N-terminal" evidence="6">
        <location>
            <begin position="121"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 5 helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY26040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="955" mass="104134" checksum="DF8F4BA535EEC22C" modified="2018-09-12" version="1">MASTSTLSPPLASTSTSTSNQTQTQTQTQALKPPLSTPARPDPVQEYATFLHPNFDPNQFAHSIVNDQPYVPPPLDGASEADTLDDGAHAASSLFMKALERDGSALKRAGGVAGGGVGGALAHLSFGVEELNRQLKAEITKHHSSLLLQAASLGGLEGDLKEVRHGLKEVEAGVTRLRRKIATPHSSLSASLQLLTRLRRTSSLARRSHRFIVLAKRLEAQMNEIDGVVVEDADKVLSKSSTNGGTHSGTGGERTERVMAEAALTLAEIELLLNEGSESDSELISIHSVPLIAAQVPAVSSSRERVVLSMESTVQRGLSTLDHPLLASSLQTAHNLSVLPQLVDALLASLNDVVSREVRRAFDMASLAKEVNAKDPSQSSGPTSFVYKSRARTEPTTMTLPLWQSTLWARMETLVSEMGAICIKVYTLEKVLKLKRDQMTQTSFLDEAMTALDDRPSAMFWTTFASTLEQHTKETARSSAFVQTTLASSYPRLLRLLHEFFTKIVVHTDTVYSPTQQSSEAVQILRAIQPFETLYLTRSSNRLLDSVGSAFSLSSASSNASRTIPTANEGLGTARAIVNELDAARFDPLLVKNVAKGAARAVDTFVGTAESLVGRIDFPTSFSPLLRVTTMTYPQISRDHSSTTLLGPLATPSQHSNAELASSLYHLWSPLHRALLGEQYGIEPVQVALRPSIDRIRHVYLNISKPLIMAIRREFSTILARMHRTDYSKSNEEGTAPNSQSAYMTDLTDKLSLVRDEILGTYRVGDLAKEWALDLSRFIVQTFLLHASLITPLGESGKLKLVADTALLEFSVSAYLSSHALALIAMGDQFKALRAWRPLLFLPDKDLVERATTGDVPTLILLHHALGRAASACREGRIQVKLPHQVQGWTQGDYVRWLNEHGETDRLAMVSMTVDAWNKEREVLARDEEDETIGQEGQAVIAIVSEILARTSSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LY31</accession>
    <name>A0A2X0LY31_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01226 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01226</name>
        <name evidence="2" type="ORF">BQ5605_C002G01226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY31389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LY31"/>
    <dbReference type="STRING" id="796604.A0A2X0LY31"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008313">
        <property type="entry name" value="GH125"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 157 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047:SF0">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 157 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06824">
        <property type="entry name" value="Glyco_hydro_125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01149">
        <property type="entry name" value="DUF1237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY31389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="315" mass="34745" checksum="F8EB0391BDBFD5C4" modified="2018-09-12" version="1">MTETHDHTADAGLPLWALTGRFTHTHTHIQGHCSFARRYTTLLAHTRIAGNSSRPVTSIPLPNCRPSVPDRCFVSALAEARLVECLASIRDRSLQTLFSNCWLNTLDTTIFDHFADNGQADLARAQPRTWVVTGDIAAMWLRDSTNQVTPYLSLLAPPPGTNPANYTPDQKEWEALYRLMLGVVYAQASCILLHPRATEPPLGSETQSADPRSPNPPLPSIVDVALVSIRRLGRLQIGSIRSPASIFVSHTLFQHCHRPHPSRSSNNVCVIVVIVIVVVVGYQVTGWQVAGDGRIRTAQQLRERMVGCNTPTAWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LY49</accession>
    <name>A0A2X0LY49_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C014g07422 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C014g07422</name>
        <name evidence="2" type="ORF">BQ5605_C014G07422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY18641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LY49"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015862801" evidence="1">
        <location>
            <begin position="37"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY18641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="207" mass="22326" checksum="C968AFD3AB47141F" modified="2018-09-12" version="1">MAMPSPLATGATPTIPAKQLATLTLLLSALTTAASGTAAPATTSGTTHTAFPKHAHLDGVKTFANWTRQLRLCLADDIRLYVLDGIVPNDWTPLQRSARDVVARKILANLINLAKVSAVLDKIPTGDLTAPKIYSTQKSRYAPDDATHTLELFLQLWGFRPMPGTVANLTGGSWSSKLLRKRSLTPRLLSCDQRSLVIREAARAGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZ34</accession>
    <name>A0A2X0LZ34_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C016g08053 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C016g08053</name>
        <name evidence="2" type="ORF">BQ5605_C016G08053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY20447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LZ34"/>
    <dbReference type="STRING" id="796604.A0A2X0LZ34"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015995703" evidence="1">
        <location>
            <begin position="24"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY20447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="222" mass="24325" checksum="BDD5554868293C07" modified="2018-09-12" version="1">MALVQTFPAGVVMRLLLEMTTYAYLVDNVVVECGGKDALRRSAKSADVGALVVVDALKARFFLDGMFNLTSIHRELLFVFDNLIVQGLRFHLPSSTKEIFPEICDHDPLALPFMEDKEASAVEVLDDSCDAHRDNASIRYSACFLLASGCFALVSNCNTWSAISTTSDTARAGAITMTVLGGGLLSTWTYLPQGQMDHILDGKSPKEMARLGTRHPGFTYRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M1S1</accession>
    <name>A0A2X0M1S1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g02518 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g02518</name>
        <name evidence="2" type="ORF">BQ5605_C003G02518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY41489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M1S1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY41489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="196" mass="21403" checksum="58F354FDA8C61DA8" modified="2018-09-12" version="1">MISVQQVKPFVQPCAFSDVVAVFVNVYAGFCESDADVVGHAGKRDRMTRGGNEGDVSRSDGVDTPCNTTNLRRSNVAIGRERRLVRDHVRSGARVNDERAVAKLTTTCEKTGGETSDMVLRVGGVGRFPVPESLLAVERPVVFLLAEATGSWRRMLRPRRALHDTVRRTEAGKTLGTGGAWRRRGEKGRLIAGDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-05-29" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M1V9</accession>
    <name>A0A2X0M1V9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C086g13011 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C086g13011</name>
        <name evidence="5" type="ORF">BQ5605_C086G13011</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000037">
        <property type="protein sequence ID" value="SGY28419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M1V9"/>
    <dbReference type="STRING" id="796604.A0A2X0M1V9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005971">
        <property type="term" value="C:ribonucleoside-diphosphate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573:SF6">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="R1 subunit of ribonucleotide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="4">
        <location>
            <begin position="2"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY28419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="85" mass="9615" checksum="4A36EC66B6282033" modified="2018-09-12" version="1">MAYVYKRDGRRELVAFDKITARISKLCYGLDLNHLEPIEITKRVIAGVYQGVTTVELDNLAAETAAAMTTRHPVSWHLHLLHSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M2M7</accession>
    <name>A0A2X0M2M7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C001g00220 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C001g00220</name>
        <name evidence="7" type="ORF">BQ5605_C001G00220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY44937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M2M7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="98"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="98"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="123"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="288"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="365"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="197"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="243"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="376"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY44937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="426" mass="48033" checksum="831354A9FDF14DCA" modified="2018-09-12" version="1">MMQVTAEIVRQLRDRRQTWADDGSKTASATLSITTAFPTTPTSWASGGSVQRRRRRRRNELPSWVRATQAVAVKSVSPPEFRTCERPFCARSVHDFGLYKTVICKYWELKIACPKGTRCTYAHGPKELRPHVSSHAKETSPRRKDHRELVAVSEHAHQKRRASRVRNKSNRSLSPTETRSHDEERRRLGGEFRYRARSNSPSALMTHSSAAPATIRKRRRSIDLPWGRGLRNISKKRRKRRLSASSTGSGSSGLAGTDPRRRDRSFSNDDDFDDDDHIMFSFVEPIVEDKDDSVAGDQDEDPYSPLYSPFSIIETDSEPTPQSRERSTVSPFLERVCRPRSPLAPMSSVVPVQIQALFPPLAPTETASASAHAPAPAVPLPPAPAPQPRPASPVVIENRLVPLDRDYFRTYFAELARRKKTVRPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M2W8</accession>
    <name>A0A2X0M2W8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C002g01299 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01320 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01320</name>
        <name evidence="1" type="synonym">BQ5605_C002g01299</name>
        <name evidence="1" type="ORF">BQ5605_C002G01299</name>
        <name evidence="2" type="ORF">BQ5605_C002G01320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY31991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY32107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M2W8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY31991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY32107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="322" mass="36238" checksum="F5C9A08C550949EB" modified="2018-09-12" version="1">MFLDDLAATESKRWNPMYALPAADASLRIVITKDDPVMLGKMAPPPRPTVSSRREFRQLNLLHGAVADGYRSLAVGDDRLALDYERVWAELDVVERIQARFRRSLAWLDKLKGNAREVLTDALWTAVWDARNAPEEGPSLESLVSFLKLPSRRYELIPSDCLTIAIHPSATGTTLDKYCFEAWLVRISGWPCATLGAIRRHIIKHPEAIWFLPICDGSHWFLARLDIANNKWELYNSMASRTLDERVLAALGDLFRLLGLKLDANKPIMPSTPQQLDSSSCGLAVINIVENELLAYTAAFDPGRPKISRARQFQRLLGDFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M2Y7</accession>
    <name>A0A2X0M2Y7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C002g01340 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C002g01340</name>
        <name evidence="1" type="ORF">BQ5605_C002G01340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY32252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M2Y7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY32252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="66" mass="7474" checksum="9487F53AED98C45C" modified="2018-09-12" version="1">MCIARLVVIQNFCVLTAPPVSLPHPRILTCVDMCKDTPARARDMCKNTPARARDMRKDTLYARART</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M3J4</accession>
    <name>A0A2X0M3J4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C002g01681 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C002g01681</name>
        <name evidence="3" type="ORF">BQ5605_C002G01681</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY34777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M3J4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015932378" evidence="2">
        <location>
            <begin position="35"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY34777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="327" mass="36698" checksum="490ED5369A6C7324" modified="2018-09-12" version="1">MRQEPPPAIRYRSLRLLDLSFLLILLFPTQTTRTRPIPIPVPVPVPTSIPNHRDLFLLLFQQLIQHLLPGMRHLLHGLCDLATPERRDQHRRVFTGHDEEVFPFFESGPSEVRDKLAGYVKDAVPFGEEHLAGLEKGRADELNTEGELDLHKTPVELKHTHNRSIGARTDPLCIVGSVKGNLDLGPRRSGYDGPFRLLRQGAIRIGSKDDRIRPPQMPRQKVIDPPLQRKVFKKDLTGSSDPSAKEVAGTVRGEEHDRHRVQQDHPCDNGMTNHDAACSSPVFIVVFVAAGRVDRIARVVRQTKAVAPKCSSSHRHRLDSGTDGRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M3J9</accession>
    <name>A0A2X0M3J9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01580 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01580</name>
        <name evidence="2" type="ORF">BQ5605_C002G01580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY34025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M3J9"/>
    <dbReference type="STRING" id="796604.A0A2X0M3J9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="1">
        <location>
            <begin position="29"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY34025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="412" mass="46796" checksum="7AFBECAC64AD59AB" modified="2018-09-12" version="1">MRTNQQKLGAEENSSLQASLAEGLDPSQKSHSTVQDAMAIIRVFGALDIFITMTCNPAWSEIVNALLPGQTASDRPDIVTWVFHGKLEALLADVLGVRRAPGVFGKVIAYVYVVEFQKRGLPHAHILLIMDPEDKPKTNDDYDKIVTAGIPDPDKFPALFETITNCMLHRRCDRPGKHTCHDDHGKCTKRFPKRLQPRTTSEDSGYPHYRRRGIHQYVKFPGTAQEEVYTDANVVPTNPFLASKYNCHVNVEIASGVAAIKYLYKYVYKGHDRTSFTIGEPGAQDEINNFLDARYVCAPEAIYRIFRFEMHDRDPAVTRLALHLPNEQQVRFDPDQGAPDLSAPPETTLTAFIKLCAKTPPDYNARNLLYVDVPTRFTWNNENRAWVPRKAESDTTCDYFFSRCLLRHRLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M3Z4</accession>
    <name>A0A2X0M3Z4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C001g00650 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C001g00650</name>
        <name evidence="6" type="ORF">BQ5605_C001G00650</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY48412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0M3Z4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019783">
        <property type="term" value="F:ubiquitin-like protein peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="5">
        <location>
            <begin position="174"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="398"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="429"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="460"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY48412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1595" mass="175935" checksum="2FF9699076B86E18" modified="2018-09-12" version="1">MIPCLFLDEDQDYYLHDDDLDRLSPLTNITVAELLAFDVAPADASLHIELSKDEPTQYSNLPYPTLQTRDAFFATDALINARKQGYRSLAVGSTCLPLGADRLWSEYDRAKDVQSWALRAQRWMDKIIVINEIDRNRIAVARRILNGLQWQEQDGLLPLPLLASGTSLVYLLRFLSQQLAYSRLYPGHDWLGEAAVNLSIESVLRAGRVQNPDFETSYGLIPSTVISLVMARPPDSDPHSVFKACFFGPPNQYRNLIELGDCMRNTPTSKSIWFLPLCSDSHWVLARINMHKRTWSVINSLSATPITAATRTAVLTLFKFLKLDIKNEFPHTPKAEQQEDSYSCGPATINAVETEVLGIGSFNAARAHMSRLRQFCRLSSLVGAVEDPKEIESIVATGAKSKAKSGRGSAAGTLSSKSTSAESGKAATIKSTNQRVASSSKNPPTSRLQTTFTKVSKPTKARELTPEEHTTWARDHPPLFRRFAEKVEDLCPVSNVDVNNPKYVRCGRCYVLVPMAALLCKARFQLHLGNKKCVNLQPISNFFRPIASGSTATSPSLGPCPGLTSETAMHYLSPTAAQGGGAPPRRTLCLRLYPKIGKRPMTELERKEVDKLEANEWKWRNDHRAPRIISVNCRKYSARDSINKDGPSLPCEECARLPKDSSCRAALRRQYAAGATRKYTNKKYVAGDTLLSAIYRRHHGLEEILDDNGQGTVYLRFAQGVASGEFDGANILEGLVKAATVKHDRMVKGKSMRGFVRSEALRDFEQAMALASPMALRVLQATIGASTSRKLQMRLGLDKSNMDHTKCRSRMRTTPYYSEDLSLERELRTKGIFRHELIGPIGPPRIYETPGELPDMFSGPDPPVAGTKIRAYMIAPNDVGSPAQVFAAFVIGETTNAEDATEQLHSVIQELIKRCVAHLLVSISADGAASEGVLQRNVAVLLRDQGGAVAQTGSRNASSYTLPSPDPDGVFPEITISTVNVAGTPIVFCRDEKHLAKCLRNAIDSGARLLFGGLGCIAYQDMLTILGGLESRRTLSRRDTKNSTPMRSYISSYVASYTMPSRTGRFSPLNVSGCCSLSDIRSRRGMTLSEVAPDLALTRSSPKKRLKGSGRWLTQRLLSSATTEIFGRRNRSFPGGMAQKWWSTSSGVYARLIRQATGKVTALLELMRKFKTEAAGSRQGYHHTYNDLNDLDLVAMRTYPSDGDISLTSFAAANTARELLSGLRMWEPVQRIASNRRNQGPQPDILVEDVLAHGTTVQGSSERLGLQVMHHHPTKEDQGLLRTELLDSALDGMRRSTCQGVVKLDPNEREAVDRAIRSLAALDFDVEAALLNVQIAYDEADRQAEERYVLETIEKANSSLRPIPTHLKLPPLVDARDTSFSLNWASLIAHRAAHECSHLRAVLLKGRPMELSDTSRGEAGLEISNTEQGRSAVHSRVLKGLVQSMGPSRFEDIAGTARSFRWTGGGQVARALTTNEIQKNAYIEDGRIQEKLPERDKQYGALAQRYPHFGSLDGAVTAATPLEIGSLICFGLKRGMHSLSCDQTAYGEEALSIGIGTFDNKPLQPRHARLVGSTLKCRRTGASPHQENMLFHIPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M486</accession>
    <name>A0A2X0M486_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g01842 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C003g01842</name>
        <name evidence="1" type="ORF">BQ5605_C003G01842</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY37602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M486"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY37602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="631" mass="71962" checksum="B0965804E383F5A3" modified="2018-09-12" version="1">MRCKPVLYDVDEYVTRGEAQVVFTKQRHIEGFACCICPEAVGKRHSPAEALRHFKTDRHRRQALRRRRFDMVDANEVLGDTPGSQAIDDVRGTVREAFPDSIYEAEAASQADQVVGYCSLYISETVVLDQSFDFDRDVDVDEPARHSHAMTACLSVGDDLHDDVESGERVDLIFTDDLESNDCHSFDDLEEEDEICQNAMADSAPLSDGKVPALRLLSKKVRRAQANTAPPVSNVFKEAIKTGHRNSLTHKPLDDDIMFDDHGFQDSDEDGEEAISLGLVNRGLCTDPDMIRLEKLRKADDRKNRDLWRGLQIVLARLTHPLNQPGLDPSVELQMDLNKMQVGRHVCYSQVETYVLIADLHDSQRSFRPYVKAIVALPRLCSFYKEAQDAVAKVLREDGLIKSKLEETSALYRRNTRSALTLAMADARSDYIEHVSRGKTVEPLQLIRLKPVVPVQLNKTSDQIKEQRDPISVMTAFLDNSLTFCDEHIMFWCLGVTFIRIRNVEHREAKYKACRAYEEFLKGVADEIARRYLEDRMDGTFDWRAYIWNTYVEPLQKESLSRTPALRNSINWHQPTGRAFLNFADKDTDSRLLDKIDKTNADLCQLVAKRVRALRETSRVTAGPRAGFRQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M5Y4</accession>
    <name>A0A2X0M5Y4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g04096 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g04096</name>
        <name evidence="2" type="ORF">BQ5605_C006G04096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY55950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M5Y4"/>
    <dbReference type="STRING" id="796604.A0A2X0M5Y4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY55950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="740" mass="81823" checksum="1F983D897A1CC0C3" modified="2018-09-12" version="1">MQPSARTCQCCASFGFDCVSLKEPRSTLDVPASESRGTPISIESPEEAQMHPVISHALGSARPADYIAAYGARYWTKGLQSYRLRRQTSTGALSSQAAQDGRSDTGRDERPGQDGDLERCVTSIRGLGDLPVFTVDELDSDQDGRLIVRFNLFIEGEVPLDALPEGDDVLYKRCSLPLGWIITVAATPAPSRAAHAPPAPAVSVQGKRPARNADPWVTSDEEESDEPTENPARTHLRQLEAETQLRQLESSADRLAQRPTKKKSKNPASPPAQRAVVSYRPSTLSQGGRVLLDEDDEDQEIPTATSIAQEKAARMYEETLAVPSTAYSELPGYVTLCHDKEDMYKEALLLPRAHVYRLDRQAAVLKKNHELKLDIIEIMKVLTGQFVSAVDADNPAPSDLFYMFQHSGNKFYGIEAMVQSKASVKKRTLTQAGHTEALMELEKLEGVVFNSHQGCDWQHYTCFLRELAQDPDLGFDFVVLYNDKYHWDLADRGNEGSSTANHGPSNASHPRSLPGKKKCNPCMRFNRGDFHDEEACDYRHVCSACKGNHAALSTLCTHRQLKLGACLADGDDSIAPDKSSLAVVISDNTGPPGHPSLSHLLGLGLAPKYQRSFHFDPPSKDYPTTPLLSLTTSVGRLPGPLPRAYFTPERLAIIKDTQQLYPSQFNFTWTIDDLYLGKLLAEHPNTILVNSFLSALRSEGFEPPHNGSNVRGNDPALVRFPKNKHHREFIQMTVDEEVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M6U0</accession>
    <name>A0A2X0M6U0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C007g04397 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C007g04397</name>
        <name evidence="25" type="ORF">BQ5605_C007G04397</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY60237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="510"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="257"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="785"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="267"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGY60237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1403" mass="156137" checksum="F2494711BA887FF9" modified="2018-09-12" version="1">MSPSETIAQESGEIKIAKLGKDNYELWSIRVEAYLESKGYASVLEHGHVRPSDVSLAEWRTMHGLDASVTDTQVVVNLQKKDRSARALIIQCIDDANLKMVKSKTLSAKDIWDKLRQHHEGNAKPFKIRTLLMELSNAKYDEDENMGEFLKSMIDKADQLDDLGQKFGDEAMIAYILQALPPSYEMLKQAIRLGENRSVDHVINRLTDEYTERKLSGKFDKLLKNAGALAVQSTQASRDPNCVCRGCKGKGHFAMDPECPKYDAKKNHGRARNRNKRKKQDSKESADSNELAEFVLTVKSLDESHSLQDNVANRVSQLNQGEIWILDTGASQHYVGDASLLSNRQSGNLKVQTASGQVVHCDTYGMVRFKLKSGASLSLANVYHLPGAPVNLISTRALFKSGAKCGWEDGKDVMTITYQGVILAKTLSGTGYALDFTRIVEDQAHVATRATVGAPLMEWHRRYGHVPVSSIMELVKSGAVEGLVLTDEKVHDCEPCISSKSRASKFSELATQVTDVLQRVFMDIGFVAEDQVDFQGRKAYLAIVDQYSTAKWTFSLKTKSAEEVTRVWIAFRQGVEKMTGRKIKRVRTDNGTEFTNKLIGADFQSQGILHETSAPYTPQQNGTVERFNGSLMAIVRAVLAASKLSWKYWSYALAYATFVANRILHAKLEGKTAYEVFYGKKPKVSHFRPFGSTVYAQVPKSKRSKLESTLVKGIFIGYDSEYNYRVLVDPDSDHKVIVTRDISVLEHKSEQVGVPEVTTLPVGPDEEKGPVDNDEIVVDELQDQVDGEQMPPARQNRPRWEYGDPAVKGRNPGRYEEIDANNEIPHRTRSQRRDAEQQVMYGSAMSVSLPPVPSNYEEAMASPEADKWIAAIKAELDAMARHQVLIDSDLPSGARALGSKWVFTRKENAQGEVTRYKARLVAQGFAQRPGIDYNETFAPVARPSTMLSLVGTAAAQGLFLEQFDFDSAFLNGTMMEMVYMKYPKGWDRPQTGQALRLVKSMYGTKQAPREWNAAVNSLMVERGYKRSDADSCLYVKRVDEKFIYITLYVDDGMVASNDQEFLDSEIEAFNKVYKLKRLGPVKLFLGLEFERTSDYIFVHQSKYIRDLVAMYGGGSVSKHPVKVPMEPRSDVEHSTDPFDDVALYQSAVGALQYAAHRARPDIVTSVRAAASKVSAPTQADWIAVKRIIRYLQGTVDWGLKFNHGGSTVFELYSDASWGDDMSTGKSIGAFVSILAGAAISWQSKQQSMVATSTTEAEILAASAAAKEAMWLRRLAADLELEQPKATLIWEDNQAVIAIALNPAHHGRTKHYNVHHFYIRERVTAGDIRIKYCKTGAMTADILTKPLARNLFELHREGMGMVGAGARVLCGGPAEAAGCLHEIASFWPSCFSLFSTTHSISHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M7N5</accession>
    <name>A0A2X0M7N5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C001g00809 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C001g00809</name>
        <name evidence="1" type="ORF">BQ5605_C001G00809</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY49727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M7N5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY49727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="91" mass="10703" checksum="C1DA2BDCF71C858C" modified="2018-09-12" version="1">MDKTKDRRANYCLQARVRSPSPHPVFVDFVCPAVSRSERRLVELRVLFFHSIWKLCRRRRISSDLLEPITEMDFEGLRASIQESKGRLVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M8Y5</accession>
    <name>A0A2X0M8Y5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C001g00908 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C001g00908</name>
        <name evidence="9" type="ORF">BQ5605_C001G00908</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY50628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M8Y5"/>
    <dbReference type="STRING" id="796604.A0A2X0M8Y5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14705">
        <property type="entry name" value="bZIP_Zip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR ATF 4/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044:SF14">
        <property type="entry name" value="CRYPTOCEPHAL, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="284"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="359"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="298"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="364"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY50628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="384" mass="41213" checksum="69E0B0EE619BC7B8" modified="2018-09-12" version="1">MRVLFPWCVSLRRSLPLSTPHPPGSQITFKRRRRLGFIMSNSWAFSQLNQLTPSPGVSPQNGPDAVAQRDDLSLSFPCDGTVLQAQLEAWTSVAFDFDSAADDMSPANSSSLFTDAVKALDEDHAARERYRVNLASAPGTYAFDSGVVEPPSDRDLDALLSTGLGPRVAALDPYASLVDPTLHLPTCGNAIASTSSASAIVDAFAGLPNSLFPSPSARDGRSSSSSKAAAPVVTSTSLNAMPKKAVATPRALKKVAAPTVETPVAQEVDFVDGDDEANRVAVEEDKRRRNTAASARFRIKKKQREQALESTAKELRDRVAALEAEVAGLRTENGWLRSLITDKPKSPVEDADLKLLLSGSRKRGREEDHEHVDGADKSVVAIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M9G9</accession>
    <name>A0A2X0M9G9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g03874 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g03874</name>
        <name evidence="2" type="ORF">BQ5605_C006G03874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY54382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M9G9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="523"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY54382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="556" mass="61344" checksum="E1501BB59F364309" modified="2018-09-12" version="1">MVNSEVSLKPLLATNVPMIFTLLVSSNFTETGHCFVYLRDILEEVAELTGLALQEDSCFDYWVVNDAATSSTHSTPCLASCRYDQLAAFTAATDSSDKVLGLTGFVLDIDSLPAEAAITLRVYEHIKARLPFVNITTRPQGRVDAPVPSGAPSASKHDLLVREKREASPSDRISGNQRPNTEPDSTDGKLVNSEDHANLPTYSEGRTTMTDLMLEAYPQEIVLDPWRPNGTWGDVLIVRMDPGSSGGLSHMWAFSASSSRTDSKGRWKGPRLDANVEYSKYSKKRCMGVFVCCDQSCPGKRRPHTLLSTASRSKLFQEETPQLVTGRPKKAATRKHLAPNVESPSDELPPCPITSCNGPMRHILCSATIARGQREECPGEIYIWHSGYHLHPPPPVSRPSPQHLEELRQLRKAAPQASAAELRMGQMTAFPQDPCHRPSTSEICPVFDSTRSISRYAPRVGHIKRNGALPDTLMSAIEAVANAGCLAYIEIPRQRQGQPLAEQIHIPDPRKQPRNDGSRSKSKNTSNSLTNSETSFCVATRTKRYSTTQLRDTRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M9I3</accession>
    <name>A0A2X0M9I3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutaminase</fullName>
            <ecNumber evidence="2">3.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C004g02993</name>
        <name evidence="9" type="ORF">BQ5605_C004G02993</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaminase PdxT/SNO family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="2"/>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY69315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M9I3"/>
    <dbReference type="STRING" id="796604.A0A2X0M9I3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903600">
        <property type="term" value="C:glutaminase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008614">
        <property type="term" value="P:pyridoxine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01749">
        <property type="entry name" value="GATase1_PB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002161">
        <property type="entry name" value="PdxT/SNO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021196">
        <property type="entry name" value="PdxT/SNO_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03800">
        <property type="entry name" value="PLP_synth_Pdx2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01174">
        <property type="entry name" value="SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005639">
        <property type="entry name" value="Glut_amidoT_SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01236">
        <property type="entry name" value="PDXT_SNO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51130">
        <property type="entry name" value="PDXT_SNO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="57"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="163"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY69315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="250" mass="27077" checksum="833144C91F7E1023" modified="2018-09-12" version="1">MVQPSHSLTIGVLALQGSFAEHVEILRSLSLPPGASVIGVRTPSELERCRALIIPGGESTTMSLVAQRGGMLEPLKRFVEDARHSRGKAVYGTCAGMILLAKEVIGAKEGYEGLQGVDCRIVRNQYGRQVLANPTFRQVESFAHPLEISSLASSSIPYNAIFIRAPVIHSLIPPHDASSPQVEVLVRVPRSVLPSPTKAAIAVGGASELGPDADVVMLRQGDILMTSFHPELTPDTRIHDWWCRTMVFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M9U1</accession>
    <name>A0A2X0M9U1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g03993 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g03993</name>
        <name evidence="2" type="ORF">BQ5605_C006G03993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY55237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M9U1"/>
    <dbReference type="STRING" id="796604.A0A2X0M9U1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47203">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47203:SF1">
        <property type="entry name" value="HYPOTHETICAL BASE EXCISION DNA REPAIR PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY55237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="271" mass="29525" checksum="C3A7C476E3D4997B" modified="2018-09-12" version="1">MLRTSTRTKTTLAVALDTPTKKSSPLKSDAPLPAPLSTPRRATRSSISISSKGEEIKIELPEVDAYMTPIKKTPVKNTLDSFKTKGETPTGVGLSPASVKKLANLDRMVGVSPYPEMIRPTPEECQEVYASKGHGVPVRPKVFQDQPNAIAGCGQTPDVLDALIRTTLSQNTTSFHSTNAKNAMDRVYGRAEYRTVLEGGEEMLQETIRCGGLAKVKAKSIVKILRRLDERQQGKGQLTLDYLHKMVSFFSVTDLLIGVDCSCGFDVSAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MA72</accession>
    <name>A0A2X0MA72_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g04124 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g04124</name>
        <name evidence="1" type="ORF">BQ5605_C006G04124</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY56305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MA72"/>
    <dbReference type="STRING" id="796604.A0A2X0MA72"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY56305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="245" mass="26744" checksum="145F02FA1754E249" modified="2018-09-12" version="1">MSDPQAEHIARAKHVLRYLKGTASLGLVYHRDLGTEIVPYSDADHAGDKSSRVSVSGHVVQMAGCAITWSARRQTGVAHSSVEAEYVALSSTCREVMWLRSLLFALGFPCIGPTIIRADSTGAIALSKHPTLHTTTKHISVAYHLSRRLQDDGHVDIRWVETNLMVADIMTKGLGKAKHEQFVEHLGLTAVARQGRCWNGLVQQKTISSVSTMGANWVEAVIASESEARDSWAQYSLESDQLGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MC48</accession>
    <name>A0A2X0MC48_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C008g05013 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C008g05013</name>
        <name evidence="1" type="ORF">BQ5605_C008G05013</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MC48"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY79013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="54" mass="6380" checksum="4E46BB06E39ED6C2" modified="2018-09-12" version="1">MCFRTRPALFRRGHKGASIEVRRSTAFFRLVLKIKIGDDECTFFERGNHHTIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MC54</accession>
    <name>A0A2X0MC54_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C008g05146 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C008g05146</name>
        <name evidence="1" type="ORF">BQ5605_C008G05146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MC54"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY79489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="419" mass="47095" checksum="AC3C1202838066C6" modified="2018-09-12" version="1">MHLLDTYNTSSTPTILPSIEERQFPHPMPNLRPVTIHFPVPPNPILCAGPGVYVPADSQADLPEKTYSGQIPNSSTPYQQPITPSCGSDLVPTFTHFSGIRPQTLHLLRASLFNLLLSLVFPQYGFSYPTMVPKPFFENDANGWATLEHLLSTAGIGPNDQPVFFESHKIGYPTGLSDPPQSRYKALHTDYFEIVGPENDIRFTTKIHDFLNANPYREWRKVPPQFNPQVHLLMAQFLKKAGPSTFDSPLLDEDGNVWPRLFAHFTDTKENDVVRYVRLAFDAQRHSGKDGFEVIERAPEDLLRKAVKAHIDKHFEDMLDVPAESCISITTESNARHDQCKVLVAVRLAGSTMVDKITASKARSTFSTRLNIPIRSMSRLAPQANNKMEPLLVEHTITGVFKRLVKTRGMQEPYAIVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MC91</accession>
    <name>A0A2X0MC91_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C008g05053 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C008g05053</name>
        <name evidence="3" type="ORF">BQ5605_C008G05053</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MC91"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41814:SF1">
        <property type="entry name" value="CELLULASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41814">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="469"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="472"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY79139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="521" mass="56475" checksum="57446DEF14D08621" modified="2018-09-12" version="1">MQILRLDVTIAISCLTLGTSWLPFAISRVRQTFNFIMFLIPSSASLRRVLMHASATASLALLLSILATLPRVHALPAYRIRPRQTQTMNNLTFAVAATSKDSTALSSKTITLIKQMLNKTARESWEIGAHIQALLEYDYPVLAVFFDTYPDLMQDTIYPYPVMSLVGSVVSRKAPKSLQLMPDGSAADPASIGVATIMANYSMRTGNRAQFGTAAEDQLEALLLHTPRLADGAISHRADELSLWYVTWSERVTAPPDHMVPPFLAYYGTINANMSLIQEAYDQCRLYRQNLLTASSGLYKHILWGSNPDPGYWATGNAWAAAGMIRVWATIMNSNYASAFASQANDLASWTMQIVEAAFSLQSANLLFHNYLDDPNTFTDAASTALLTAVSFRLAQFKISESTLAKAQETRIALHSHISSTTGLLSPVVDPLSFGRIGQQSPEGQAFVLMMEAAWADYTAMSTVPNPMGASATESLGDSKTNASGSGTSGARALHGGGGGEWTRDVITVALVLATVYAIYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MEM3</accession>
    <name>A0A2X0MEM3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">BQ5605_C038g11679 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">BQ5605_C038g11679</name>
        <name evidence="18" type="ORF">BQ5605_C038G11679</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000061">
        <property type="protein sequence ID" value="SGY91553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MEM3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="17">
        <location>
            <begin position="8"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="291"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="SGY91553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="992" mass="109022" checksum="CF0CA796CC0ED370" modified="2018-09-12" version="1">MLSAKGHRLPFPDSDSHASERLGLVHSDVLSLPERSLTGKRYLVTFLDDYSRKLWAYAIGHKSEVFSVFKTWLAEVELETGATLKVLRTDNGGEYCSRAFTEFCKARGTRRQYSIPRTPQQNGRAERVNRSIVEGILALLADAHLPKTFWEEAAAYFVYCKNLVQHSALDKATPNSVWQGGRTTASALHPFGCAAWLTVAPELRSKLDPKAVRVLFTGYDLASKAFRFYDTATKKVTLGRNATFLNTEFPGLRCDSAEQDDDTHFASAPFADPHTTVKPWTPLVRSAHMDVSSPLDDSSMSAVDVAPGYTGGTLLNSTDAESPSSPSPAPSLSPSPEPASSPSPAPSPASSPSSAASSSPSVSPADSEYSADPLDLIGSQPQAPPDPLDAQPPDFSTYREPASAEESPDELDLIGHHSRDESPDEIDFLARHHRAFIATDDDNPEAEAIQPVKSITSDPQTWREAMSSDKREVWAKAATAEFNSMRDDFKVFTIDDRSTVPAGATVVTSKFVWKTKRNALGEITGHKARLVAQGNRQRDGIDFTDTFAPVARFSSIRSLLALAATNGLHVHQADIDKAYLHGDLDHDIWMTAPRGFDLPGDKVLRLRRSIYGLKQAGRIWNRHIDASLCDLGYTATGTDHCVYSRLDDRQHPHYIALYVDDLLMISPDLAEIERVISGLEQRYGVKRLGPAEYILGIQIRRLDDGSVALSQERYIMDVLARFHFDTTTRGTTVPMTPGLSLTAVPGQATERIRSWYLQAIGSLLYISLGTRPDIAFAVSYLARFANNPGHRHWIAVKHILRYLRATYRDELVYTRGQARITGVVGYSDANWGACVDTSISTMGYVFYIAGSAVSWSSKRQSRVADSTTDAEYLALSHAGKEGIYLSQLLEELHVQPVAPAHIFTDNEAAAAIARDPVRVSGTRHIRLREHFVRDMVNRGDISLSHVGTSDMVADIFTKALGPKVFSTHCYALGLRTRHPRLGSASHSRGGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHA9</accession>
    <name>A0A2X0MHA9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C008g05261 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C008g05261</name>
        <name evidence="2" type="ORF">BQ5605_C008G05261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHA9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY79968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="409" mass="46581" checksum="836E0EDFBB1DB09D" modified="2018-09-12" version="1">MLPACNPGCWMAPGLGQLANEIDLLLGSYFEGHPDYKPRGLRSDARIRTNIPGTRHMVTYTAGQFQQRTFDEHARGEASSPSPRPPMAPPVQADFDEAANPSGMDWDDERHSEYGGGYERDFSPAPYFPDRTSHIPIAPDYSATAERLSLADLRQDESFEPATRGQSKQETYKQFVFNDARLRSLERPALLRQYIAFWLGQKRKRGGGSARVLKEYRTRIQDFDDILARSFTVPVDIAAEYEESRLFREILSPLYQECQRPLPEDEIRTDEDQEGSDRLFKMDPKESEHRTWQAALRPFATTVLVRMLVHVPEPPKPPTDADLEPERKKIWDSWIVECAHRWLALLSKQRETYRWMRKREEDAISEHSSATGQHSDHGSAAGSEAKSNLSALSELTSLSKLERGLDTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHC6</accession>
    <name>A0A2X0MHC6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C009g05723 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C009g05723</name>
        <name evidence="8" type="ORF">BQ5605_C009G05723</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY84857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MHC6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070139">
        <property type="term" value="F:SUMO-specific endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051947">
        <property type="entry name" value="Sentrin-specific_protease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896:SF3">
        <property type="entry name" value="FI06413P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="7">
        <location>
            <begin position="840"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="142"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="224"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="334"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="722"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="974"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1101"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1389"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1617"/>
            <end position="1789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="184"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="405"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="726"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="755"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="792"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="980"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1120"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1160"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1174"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1444"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1635"/>
            <end position="1645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1767"/>
            <end position="1777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1779"/>
            <end position="1789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY84857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1789" mass="193787" checksum="D32E0EDBDD10924B" modified="2018-09-12" version="1">MSSHSSLHKDNFGFPNAPTTSASAAGASSSVLTPAQADTTASTSSHQLLDLTLLDHEEESPPIVTRTSRGPPRIDRNELRPIQQQGPLPNRQVLAASFYSAASTPAPLTHRIASNRITTYGNSRRNADRAWDVHYSVDSDNRSTSLDMSHGHKSGVPFAPQDPTMKGKSRQFSGYTAGNGGWSNSGSSSHSYPQPQHQNSGTRRRMSGPSGILGEVKIFHQAMQSAVPRAKPASRRNPTQTLPLDREPKPDQVASMKRIGRISQGAPVDCPSNLSPACSFWSSRLSLMLTSNFVRPIAESRRLSPDTELTSKRTLSQAAGAAIERRANLGVQVKGTADATSKAPQIDVKGKGKAIEKPPEPPEPLKTHLEISSDEEEPNQDLEDDIEGFDDEKPRQNSHRHGQRRASTSAAASNDSRLNNKESSPDALAMPDKAEPAVFHRDRDQSTPIVGPFTRGHAGVGEGARHAQEVIGGQNVDVKKQASVINRMQPRNGSKPVSSTPLAASVRSVNGDGNPSNDLILGPSKKFIPRRANKPKEDITSVATMVFVVEALGIPYRIASTGDCRIMHNSKGVAGLQQLTLRCGADDVCYLRSSDMSGFEKLDDNKNLPMLAIKLSASATEAATKLAHACKFRREGKLNNQIVVWLRFICEPLGNLPEDHAVRRIFDLVARDWPKHLYNKHQIRVDSALTTSPRASDHPCSCLARSSSSAMATRIEMFDAAVSSGRPMSTRRQSAGSVNVDSATSTLANSPRTRQTSDRDGAGSGVKRGESPQELENGMTSIGQRTKRVPRKSAEAARGRFAEATADTVDERYAWQIEEDGTPLERTVLVYPLQGDKTVVSVTHGDTKRLVDGKYLNDTLIEYGLKRAFLNLVERDTKLVEGSKPLAPLVHMFNSFFYKKLDRRGLGKQQTYDSVAKWTAKFDLFEKRIVIVPINEKNHWYLAIVYNPGAILKGDLTVPKQTRQTRHSLLEKADAMATESGVSSSAGSATDTTIEQPDVPPPDLQEPVETSRFFQNPRSSKKAAKPTAFKTDKSEVDVDAALVEETPEDPSAMEIDELADDANLYNGEGLAAKIEIGKDEDGTATTTETVLTDGEVTLASVPNRGTAAETAQLSRNEVLASSSDTDAESSSAVEKALVGPTAKVNLSAPTSAQSGKPLKRTPTPISPSTRPPGTRSPPPPPQPPRQAKNDAAELTIGDSDNEATPLPPMDVTTQCYIMTFDSLGDAHRPVGKNLKDYLRREALAKKGLDISESWVESNAEAFAVDVPQQDNCSDCGLYLIHFVEQFLVDPDDRLRYILPDPEPFNHNVQRYRDEKTRAEKAKDSSKENKAAQLQELLRQRDSIWKGAAAKSKRGELREEVKVLAEQWAEMRRPLEEEEARKRLERAARKAEEKEARLAAELAQTRAEHGDDMADLPDEAKATNPSPSTRVKRTLGDDAPLAATRVEEVEKEKTPKATSEIPDVAADGPSGGENGKPVTTYGKKGKAAAGKSGKGKKKEAQEIILSSGDESNEPSVSPPKRMRPLDDKLSVPIAHIVPPPRAPRHTSTRLTAREAALRAPMVTPVSAEASTSAFKRPLALFPPAPPTVAPVNANRSIPATIDSSRDINVDEAYQMITEVGQAAPAPDSSPLEVASIGTTNAIQHHQSVLPPPSAPYHPSRSTRSRDEVESELPPNKRQAVSSEVGSASALPANGSAVVSGGDFSTPIAKKSGHRRQISQSSDSSELADLPDHSRDEMEMPPSAQTPRAVVPAVSKRVPRASLRHSDKAQSTASPSNNKSNRREPDVVVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIH5</accession>
    <name>A0A2X0MIH5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C009g05702 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C009g05702</name>
        <name evidence="1" type="ORF">BQ5605_C009G05702</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY84535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIH5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY84535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="114" mass="12634" checksum="7436B63171910ABC" modified="2018-09-12" version="1">MTGCSVGKKGCQGWRMIKGLQRQVARGTHDELKTVAGKSAARAMVSASRWHAWSNKLQSPQGTTLVTSACATLGRERKNLDSFRHPFRCVGSSIHFIVEIRVVIRESPCNTFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJ92</accession>
    <name>A0A2X0MJ92_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C029g10683 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C029g10683</name>
        <name evidence="1" type="ORF">BQ5605_C029G10683</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ15582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJ92"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ15582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="71" mass="8687" checksum="2C4CC2EFB01ACACC" modified="2018-09-12" version="1">MTHRTLCPNTLSEHIRQQKRRERVIIPFRTVLGLELIGCWRKMRCHFTEIFLCGFGRQRWTSVQRLFRVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKF8</accession>
    <name>A0A2X0MKF8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C034g11299 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C034g11299</name>
        <name evidence="2" type="ORF">BQ5605_C034G11299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000065">
        <property type="protein sequence ID" value="SGY99713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MKF8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY99713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="189" mass="21065" checksum="C82F74D00F49E3D5" modified="2018-09-12" version="1">MLFGLLRPVTRLASTVVRSIYTTSTALQSSRRTYDTPSSAKLAGGTSGLTTPITIVLALGGGAFLYTAYAKEEELIHPHLPSKDIMEMTQSEQVDLRAHKAALDKELARIEEAHPGALERRKECEERRAKIKAHEVMLMQHRHAEGCPHMGGKMQSWPETKRAQAAEDIKTDSKMDAPQKKREEQGIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLD3</accession>
    <name>A0A2X0MLD3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C030g10786 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C030g10786</name>
        <name evidence="2" type="ORF">BQ5605_C030G10786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000069">
        <property type="protein sequence ID" value="SGZ08322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MLD3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016149655" evidence="1">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ08322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="45" mass="5297" checksum="13EC14677A08281F" modified="2018-09-12" version="1">MRSHYFAIILLHCAWFGHVALATLVAFQKNIPEHRLQHCKPTRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLZ7</accession>
    <name>A0A2X0MLZ7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C024g09938 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C024g09938</name>
        <name evidence="4" type="ORF">BQ5605_C024G09938</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ26553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MLZ7"/>
    <dbReference type="STRING" id="796604.A0A2X0MLZ7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="3">
        <location>
            <begin position="73"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ26553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="204" mass="22347" checksum="36AE9BCAF78B24CE" modified="2018-09-12" version="1">MEASSRAPTQGGPQPPIGLRLGAAPNRSRADRSRPQAIASAPSTDEGEPDGVSLKEFTAFVIKMGHWASGTAVHYKESIVVAAEATINLLAPGLPLGKRFESHQVVLMADARPWHLGDRLESDGKWRIILFAGDVRDLTQRQNWTRSRLTSTPLSPSADRRSDILWPQRARSVPVTISRSFSDDESWFSGHGEFFAGFMMPVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MM36</accession>
    <name>A0A2X0MM36_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C030g10857 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C030g10857</name>
        <name evidence="2" type="ORF">BQ5605_C030G10857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000069">
        <property type="protein sequence ID" value="SGZ09243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MM36"/>
    <dbReference type="STRING" id="796604.A0A2X0MM36"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ09243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="191" mass="21195" checksum="7BC7ACD4F9B3DF42" modified="2018-09-12" version="1">MPGTSIPATATPLITTEASAPPTVRRQYSLLLQELARWVERHPGTSLQPAEISALTYRRGRSSCLSLLWRSQVSDPRKARVKELLDANPNTLNQSRPRVDSDSDREDPSYEPAYKARKTSAVDTGTRSSRRLAGDPPLTQAKDSNRPITLPVFEEAESDLSSSLAWIDSDPWLELVGGHLPIALNSEYRCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MMK0</accession>
    <name>A0A2X0MMK0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C025g10096 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C025g10096</name>
        <name evidence="2" type="ORF">BQ5605_C025G10096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000087">
        <property type="protein sequence ID" value="SGZ27261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MMK0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ27261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="302" mass="31859" checksum="053A47446DCF270B" modified="2018-09-12" version="1">MQTGDPGSAPGARAPPPPASAPTSLPIAGTKETQATQVAGRTATYAAATNSPVVSNETPAQQQDRLARLQALPGILAAIQAVPGNRADRFVQAIFATPDFPSTVATALKFSALNATRNIINPFANALEVSLSHKSTGRASATDKGELVACVRTLLSPNTPICFDTGVPLSGDLEAFMPRITGLQHSSTFRTGVLHHRITVGFVSAEARDAALASAPMLVWNSANARFAKAHPFHRNMLEMRINVGVVRPPSKEQIVAAFQSIVQQLSTKGHSCQLVQVLRVIYPAFAVYLPSSGQTRVLAPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNK2</accession>
    <name>A0A2X0MNK2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C058g12700 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C058g12700</name>
        <name evidence="4" type="ORF">BQ5605_C058G12700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000091">
        <property type="protein sequence ID" value="SGZ29090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MNK2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retroviral polymerase SH3-like" evidence="3">
        <location>
            <begin position="29"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="282"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ29090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="757" mass="84008" checksum="CB8187CEB18CFC48" modified="2018-09-12" version="1">MIPRIRSWRRELIQGGVSVRRRSAYALHWATVPGHRCDKLDPKGIPLVFVGYDRHAKVYWLLDPTSMRVSLSRNVKFVETKFPFLSMPKCATAPSIPGYRPIAQPMLQPEGPRATPNQLPPPNDELPAPDDEAASVRSDATNAAEVLPPPEQVPEPPAKVKPAWEYGDLARVGPDPGKYGEVDPRNIIEGPRTCRRLVPTMIAKEQLNSGPDGPTNTFKNLILAFAATTEGFAEHDLAMVRDPANWGDVIRTGQEEVWHPPARDKFDSLLNEYEVFEIIESCDLPSGEILLRLGWVFRTKQNQHGDITDHKAQLVAHGCSQHPGLDFEKNYAPVVKFTSIRALITLAAANGYHVHQANVNKAYLHGKLDKPLYMCVPQGIDLPGKILKLSKSIYGLCQAGTIWNAEIDSTLCSLGYIPTKSDICIYRHDHDGHSHYITLYVDDLLLVGPSRLGPAEYILGIQVKRGQDGSITLSQERYLRDLLDKFRLGNAKPASIPMQPGVVLDFQDSSATPQDRTRYLQAIGSLMYAAVGTRPDLAYVVAYLARFSCQGKATETHGSKLKPKEVIEAQDHRDNWKLLENLGLLIRDISQQPSPAHWTAITQVLRYIKGTLDLGLTYCKNNVTFHGYSDANWGACLTTSRSTMGYAFIYSGAAITCGDAIHLSELLAELGHPVPGPVVIYGDNQGSLALAQHPTNHQGSRHVRISEHYVRERVTKKEIDVVYIATADMFADIFTKALGPKPFLFHWENLGLRGTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNR0</accession>
    <name>A0A2X0MNR0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C021g09387 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C021g09387</name>
        <name evidence="3" type="ORF">BQ5605_C021G09387</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000083">
        <property type="protein sequence ID" value="SGZ21599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MNR0"/>
    <dbReference type="STRING" id="796604.A0A2X0MNR0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039327">
        <property type="entry name" value="CON7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167:SF3">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="400"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="622"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="358"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="638"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ21599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="657" mass="68881" checksum="32C24C368047447D" modified="2018-09-12" version="1">MTEFSYPAPALDSPAFSRGPGSVQTQARPSSSSGPPNSAGAASSYASSSYSPLTDPAGSSASSSAAAAANNAARQHASSAFEHLANAAARQDDGDSSAGSDRDQMASSNSRRISVQPPRHHLPSPTHRLPSPAQSQYLAHARQSPLGGNHDERGDQSPLSQNLSHVPTAQPPPPPPPFGHAVHFQGHPTPHIPGANIRNTRPMTAPSSVSAPYFQGGPYAPHHGHSGSFYPSSMPYPFSLGLDSGISPSGLPMVMHGGHISSHDPRSFSMSEAGHAHSEHQRYSSGPDEHGSPSSSSIFQYGPPPRASDAGFYPSSQDHDGFSHSRPTTADSRPGSSHAQAQTLRRGSEFSPPSQGKGSNSESRGQSGSSSKAYNFVTAAGQTTKRPRRRFDEIERLYGCDYPGCQKSYGTLNHLNSHKTMQKHGPKSTPAQFKEMRKAWRDTKKMQASLNGRSANNLTAAASTTTATSQAQTKSIYGVPSKDRVRPVTSAGEYHYNAPAPYLPPPSTSSIYGIPAPTLQLPPPPPSMYEAPAPPILSNPWASTGPAAFPLPPAPASAGSDLLYSHGSSPHRPVTAPTYYNQHTPSFGLQPTRFGFGINGGMAPGPGPLQPGRRLSLPGEIQQPTPIFGFNVPGGESGFSSIQEEESSSSAAQAGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPP3</accession>
    <name>A0A2X0MPP3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">BQ5605_C017g08501 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C017g08501</name>
        <name evidence="14" type="ORF">BQ5605_C017G08501</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the polysaccharide monooxygenase AA14 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY20159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MPP3"/>
    <dbReference type="STRING" id="796604.A0A2X0MPP3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054497">
        <property type="entry name" value="LPMO_AA14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22810">
        <property type="entry name" value="LPMO_AA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016142264" evidence="13">
        <location>
            <begin position="22"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="392"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="392"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="429"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGY20159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="453" mass="50492" checksum="C86685282910227F" modified="2018-09-12" version="1">MRGLIMFELLALMMVLEKVQGHMTIWSKSMYGVGKDFKSVVPGQPCDPIGPDLKTRDEWWFRGPAYRALPPPEGEVTELIAGKSVTFEISCHVAWTSFGWSTTKPGSHLDACPGNPGAYHSGDPLKDSIDENLLSGCALAIADVDDIEKVTPDNLVIFSVQSQCIKQKITSFEVPAAMPPCKGKKCICGWFWLANTGAVNFYMTAFDCAVTNPSPTSIRPIQFPLLDPYICENHLHNQSCIQVQQKYAKRPIYAYNEPQNVKWVSNEDRAGYHEKWGWVDGAQEGIFGEGKVVGLGSSERGRGVEIKGDVMNATTMAAIGKATITSTKLDKTTSKPTATRATTTIQVQYRKAPSAHRTPEPQGVKCKNNKSKHAAAVLKLKLMLMMTDSTRAKPRIKPKHKSKHHNHNHNHNHTKQKHYRHTKQVQPRRSSKTQGRRQSSKTGRPKLRMTSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQG2</accession>
    <name>A0A2X0MQG2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C026g10166 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C026g10166</name>
        <name evidence="5" type="ORF">BQ5605_C026G10166</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S5A family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ27697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQG2"/>
    <dbReference type="STRING" id="796604.A0A2X0MQG2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000005">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="5"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="148"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="339"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGZ27697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="396" mass="42576" checksum="9E288B71C8DDBD96" modified="2018-09-12" version="1">MSLEATMLVLDNSAYAINGDFTPTRLEAQSDAVHVIFNRKLNAHPESEVGLMVMAGPAPQVLVTPTQHEGKLIAALHTIQPSGQADLETAIKVAQLALKHRQNKNQRQRIIVFCASPITTTSATLSKLGKKMKKNNVAIDIIAFGFSSDSPDPDNDEDADVDLSIPSVPSSSTPQESTPTTRTETTQHKLTTLYEAVNSSDNSHLLFVEKGPFLLSERIAQSPILRTQGTEEDYSQFGGQGSVGVARTGEEDGFGVDPNLDPELAMALRMSLQEERARQAALEQVKGNNTAAGVGADMIKEEQGTVEATDQGAEPMETERLLGAEVVGAAGVDDVEIEHDGEEKDDLAKALALSRGAEGEEGDVEMEEEQEMARAIAMSMQEAQEHEATEAKKEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MS67</accession>
    <name>A0A2X0MS67_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trimethylguanosine synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cap-specific guanine-N(2) methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C001g00952</name>
        <name evidence="9" type="ORF">BQ5605_C001G00952</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78479"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="Rhea" id="RHEA-COMP:19089"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:78480"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="Rhea" id="RHEA-COMP:19090"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:78508"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78471"/>
            <dbReference type="Rhea" id="RHEA-COMP:19085"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:78472"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78475"/>
            <dbReference type="Rhea" id="RHEA-COMP:19086"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78476"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY51026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MS67"/>
    <dbReference type="STRING" id="796604.A0A2X0MS67"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071164">
        <property type="term" value="F:RNA cap trimethylguanosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019012">
        <property type="entry name" value="RNA_cap_Gua-N2-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741:SF32">
        <property type="entry name" value="TRIMETHYLGUANOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09445">
        <property type="entry name" value="Methyltransf_15"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="271"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="294"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY51026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="397" mass="42756" checksum="6CBDD9C821BF53CF" modified="2018-09-12" version="1">MRAGRSSRAHAITNSPFVRALIRPVRSIIPDQNEVNGQALPPKASLIPTQPEMGPVASTSTLTELGSEAVNGAGANGKRRSEANGNGNGDEWEAVQTNYDAENLPDELKKYWFQRYRLFSLFDQGVQTDREGWFSVTPEKIAQQIAERCRCNVIVDAFCGVGGNAIQFAFTCEKVIAIDISPTRLACARKNAEIYGVADRIEFIQADFVEWAKEKAKRLEAKPNEEEIEVVFLSPPWGGIDYLSVDAKGNSMGTGEGTKMVEMGTPTPVAGEAAVEASTAGSRKKKKRRKSGVAPTPATPTASKTSSSASTTYPLSALAPLSGQDLYALSAALTPHIAMFLPRNVDLVEVAQLAPRKNGEYAEVEIEEEWMGYKLKAVTAYFGGLTCNAAAAAEAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MWA2</accession>
    <name>A0A2X0MWA2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Negative regulator of the PHO system</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Serine/threonine-protein kinase PHO85</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">BQ5605_C004g02912</name>
        <name evidence="17" type="ORF">BQ5605_C004G02912</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">When phosphate concentrations are high it phosphorylates the PHO4 transcription factor thus establishing repression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with a number of cyclins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY68706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MWA2"/>
    <dbReference type="STRING" id="796604.A0A2X0MWA2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000062">
        <property type="entry name" value="PHO system negative regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000410">
        <property type="entry name" value="Probable PHO85-cyclin-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF46">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="3"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="SGY68706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="374" mass="42463" checksum="5EABE39AE0A26E8D" modified="2018-09-12" version="1">MNYIQLEKLGEGTYATVHKGRSRITNELVALKEIHLDAEEGTPSTAIREISLMKELKHPNIVRLYDVIHTEAKLMLVFEFMDLDLKKYMDSHGDRGALEPAVVRSFMWQLLKGTAFCHDNRVLHRDLKPQNLLINKKGELKLADFGLARAFGIPVNTFSNEVVTLWYRAPDVLLGSRTYSTSIDVWSAGCIMAEMISGVPLFRGRDNNDQLNQILRILGTPDEATLRRIASESPEIQLRPFPRLNRVPFASLYPKAHPVALDLLDKLLQFDPARRIDCTTALHHPYFGQAAQQQTAQQQQQSSLQQQQQQQQSLLQHQQQQQAQAQAQARAQSQAQYRDQPGADCLEVLDLNYDCLILSIVLGARLHAVLPFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MWA9</accession>
    <name>A0A2X0MWA9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g02509 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g02509</name>
        <name evidence="2" type="ORF">BQ5605_C003G02509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY41410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MWA9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY41410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="92" mass="10370" checksum="325A1DC1EA5E3795" modified="2018-09-12" version="1">MDRQVDLHRFVRPRFEAVPHVSRDAGSSKDATVTSATTVVDRRPAEQRPRHQRARERSSQTVPTALLPLPEGPFRRHDLGPMTLQSPICSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N097</accession>
    <name>A0A2X0N097_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C006g04120 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C006g04120</name>
        <name evidence="7" type="ORF">BQ5605_C006G04120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY56273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N097"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002884">
        <property type="entry name" value="ATP-dependent DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003840">
        <property type="entry name" value="DNA_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23274">
        <property type="entry name" value="DNA HELICASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23274:SF51">
        <property type="entry name" value="OS03G0423850 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02689">
        <property type="entry name" value="Herpes_Helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="6">
        <location>
            <begin position="30"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication helicase" evidence="5">
        <location>
            <begin position="121"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY56273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="196" mass="21611" checksum="8710BC961F3FA82E" modified="2018-09-12" version="1">MVLDLLPGEPQTFYSADSVENEDESLFSIEYLQSLNIPGMALHAAKFKVGCPVMLLRNLDPAAGLCNGTRLLLTRLHTRVLEAIILTGDHAGQPVLLPRITLKKGSSAELPFTLHRTQFPIRLAMAMTINKSQGQSLAQVGVCLETPVFSHGQLYVALSRATNVDGVRVLLHQTENEEADNVTENIVFRMVFELMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N0Q2</accession>
    <name>A0A2X0N0Q2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g04270 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g04270</name>
        <name evidence="1" type="ORF">BQ5605_C006G04270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY57435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N0Q2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY57435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="82" mass="9485" checksum="AB242893D96C0090" modified="2018-09-12" version="1">MTLRQWQNWMVEGTTLRCGRHAKPVVWETESHVPGCFDGKWNLGERWNLGEGRRSGLVDAETALANWDALDRELSMTSRHVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N0U8</accession>
    <name>A0A2X0N0U8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C009g05706 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C009g05706</name>
        <name evidence="6" type="ORF">BQ5605_C009G05706</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY84589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N0U8"/>
    <dbReference type="STRING" id="796604.A0A2X0N0U8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051964">
        <property type="entry name" value="Chaperone_stress_response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="5">
        <location>
            <begin position="26"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="386"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="485"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="526"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="630"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="399"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="415"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="536"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="584"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY84589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="650" mass="71743" checksum="6CE5C955384E1DC7" modified="2018-09-12" version="1">MGANASTESGSGSAGSGQRKPGAPLDHYEVLGISTESTSDEIKKAFRKAALREHPDKNPHDIQGSTKRFAIIQAAYEVLSDEQERAWYDDHREQILNGGQANEGPQDLAAEASYFDSLRRGGTSVPKPRSASTRGVTIPQLMKFFTTSSWSGFDESATGFYTTFRTLFALIASEENALRSTYTYPTFGTKESDYESVVKKFYTGWLDFATEKEFGWLDQYKLEDGMERRMKRAIEQENKRLRQGGRREYNETVRNLVLYVRRRDPRWQAGQSTLSPEAQRAAELAKIRADLLLAAKERALENGQLAAQYQAQDWQKGNDEVFKQWEERSEEDEGSEEGENEDEQWCVACGKGFMSGGAWENHERSRKHQKNLERLIKEMQEEDEALGLGRTEEAGQENVGEEEDLDDDEGEDGDSPPIASTSRSPSPTSSLAEDVAAFNLASTNDPEADGEVPLPTKTKKKKRRKVATATSMDEIILDEPDLDTLGIAKKSKKGKKKGQSGISTPIQMDAASDLEEYEALGKQVKEVLLPSGGKTQEGRRGRGKGKEAKGSGSSTPAEGGGMSTPTESRGAKEDLELAMAEEAEMSKKDKRRLKEAAKKAGTGTEEKCHVCSVAFPSRTKLFDHIKVTGHALAEGSAPTGKTSSKKKNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N443</accession>
    <name>A0A2X0N443_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C005g03226 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C005g03226</name>
        <name evidence="7" type="ORF">BQ5605_C005G03226</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY72891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N443"/>
    <dbReference type="STRING" id="796604.A0A2X0N443"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="268"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="352"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY72891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="367" mass="40836" checksum="D72F26DC661D3782" modified="2018-09-12" version="1">MSGLPPSMDEERLKALFEAYVNPSGGRTLEELLKFKDRLKGAEAQRLRGHFSSYGLHPADCQDPIFVADFMTGRLKALQQRWEDDVKEAKRSVEEARIKWENFRDSPNQLPIVDILQIGAWTQLSNVKSIPEQYYDCLEFLIKKVGMSVEGTDVAGYTALQHSLTCTPLLHDFKWSSLLLQACPDPITAINHRNRYGTTSMHEASMTLMRPGETENRAKVLRWLLEHGANADVLDGDHCSPRSTGGRVPQFKQIIQEFDQVQIKTEACGFCRRGGFVGKGKAKAANSASGEANLKERTQGGNEEGVPLRANLRCGRCRARNYCGAACQKMDWAAHKKQCVAVASNAPSQSEVESKATSEVKKEETTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N446</accession>
    <name>A0A2X0N446_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C030g10821 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C030g10821</name>
        <name evidence="7" type="ORF">BQ5605_C030G10821</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000069">
        <property type="protein sequence ID" value="SGZ08862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N446"/>
    <dbReference type="STRING" id="796604.A0A2X0N446"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990444">
        <property type="term" value="F:F-box domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062026">
        <property type="term" value="P:negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070372">
        <property type="term" value="P:regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052449">
        <property type="entry name" value="STYX-Interacting_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46588">
        <property type="entry name" value="SERINE/THREONINE/TYROSINE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46588:SF1">
        <property type="entry name" value="SERINE_THREONINE_TYROSINE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="5">
        <location>
            <begin position="49"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="6">
        <location>
            <begin position="99"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="204"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGZ08862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="259" mass="29095" checksum="27971FBBA05BC261" modified="2018-09-12" version="1">MSGISPALQRLEEALPNRVDWRYEMRREAQQILPGELRKTTLNWGAITDAVGGGFVAGLFIGPFQPSWNLETLNRLGITHILCIAESREQHLFRAKFPERFVYLILEVRDADDQNLIKIFPQTQAFIDGAIEMGGAVLVHCGDGISRSPAIATAYVMVKHGLTHEDAFQFVQSRRFCVAPRLGFQHQIEAYAPIFMASQTMTMAQNQGEIHSAPREKRREREDDDEDDEEMGLGGGGSTMNPDLDMHRRVPTAPQWGMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N4E3</accession>
    <name>A0A2X0N4E3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">thioredoxin-disulfide reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C005g03326</name>
        <name evidence="12" type="ORF">BQ5605_C005G03326</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="3"/>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY73894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N4E3"/>
    <dbReference type="STRING" id="796604.A0A2X0N4E3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000064">
        <property type="entry name" value="Thioredoxin reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="11">
        <location>
            <begin position="93"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY73894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="442" mass="47562" checksum="51623DE4C15E5B04" modified="2018-09-12" version="1">MLHRPLLSFTLSSTTTRLLPRSTPTRAFASTRSSSSSSSRFNQHQHHHSATFLSLLTACAAVSSTHLSRPLHTMALIEVNGGAAAEKPSKHNKVVIIGSGPAGHTAAIYLARANLEPVMYEGMLANGVAAGGQLTTTTEVENFPGFPEGIRGPEMMDLFRAQSIRFGTKVHTETVSKVGKFIAPFHQYGCEIAASAVVSKLDLSSRPFKYWREGAEQEEPETAETIIIATGASARRLHLPGEETYWQSGISACAVCDGAVPIFRKKPLAVIGGGDSACEEAMYLTKYGSHVYVIVRRDVLRASKIMANRLLKHPKVTVLWNTEPVEAKGDGDLLQALVIKDTKSGETKDLPINGLFYAIDLVCNGFAGHEPATSLVRGQLKTDEDGYIITEPGTSLTSVKGVFAAGDVQDKKYRQAITSAGTGCIAALEAERLLAEEEVHDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N4W2</accession>
    <name>A0A2X0N4W2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C028g10554 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C028g10554</name>
        <name evidence="7" type="ORF">BQ5605_C028G10554</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000080">
        <property type="protein sequence ID" value="SGZ13176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N4W2"/>
    <dbReference type="STRING" id="796604.A0A2X0N4W2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016109612" evidence="5">
        <location>
            <begin position="19"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="6">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGZ13176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="275" mass="24416" checksum="F75E62A6CACF54A6" modified="2018-09-12" version="1">MLAKSLLVLVAAAAGVNAQQLPSCFTIKISEAGSLAPGIDPTNIAGLCGVRTFIGAFVNCCNDNCASAAEVATSVALAQQVCASAGVAIPTTGYSGAAAGEIASLSSIPIASVTSGVSAAASSVSAGPSASASSAMSAASSVASGASASAGSVLSDASSAASGAVAGASSVASVAASGTGSVASDATSVAGVATSGAGSVAGAATSVAGVATSGAASVAGAATSGAASVAGAATSVAGAFTSALASATAKAASPADKAAVSGVLGFVAGVVALFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N6S6</accession>
    <name>A0A2X0N6S6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C008g05367 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C008g05367</name>
        <name evidence="4" type="ORF">BQ5605_C008G05367</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY80355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N6S6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032549">
        <property type="entry name" value="DUF4939"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16297">
        <property type="entry name" value="DUF4939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4939" evidence="3">
        <location>
            <begin position="93"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="285"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY80355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="587" mass="65788" checksum="FB2169BB19AEE92F" modified="2018-09-12" version="1">MEDLTQASLDSLIDQLRTLQARNQALEAECRSHLSDKENYQITVTALANQQQTLSDFAKAVVDQQKESIDVIKSGLANLNVTAPANTTITPVKSQLAKPDKYDGKEKVKFKTFITQIKFYIFGNPSYFPTDESKIAFIISHLTGDAFQHFEHAINAKDDSKPEWLTNYQKFLEQAELVLGDPDYRNNLTRQLMSLVQSGPASVHASKFTQISSQLDWNQAALIAHFHKGLKLDLQAQLALHDDPQDLQSLIELAIKVDNKLHLARHRTNASTQFRQTNWQYSHSVNSPLRTSPVSQLQANPSTANTSGPAPMDFDATRSRRGPLSKEEKLRRRTNRLCMWCASDQHLRAQCPTAPPMIPRHTALNASPRMSCTGTLFPQVSSPPSPRYSQQNSTRFPKTTLFCPSYSISSPHPDLATSFVHDNHLQLIAHPTPIPLYVIDGRPIQSGNITHFVHLEVQFNGHTQSLRADVTQLGTYPLVLGTPWLRLHNPIIDWKRNTLVYSCQSCALGHTQPINVSIEGAPLVPLDHKHLDISFASSFAFERLVNNSDNHHGLLFYDPTSHQLSSSSPAPSQSLSDDNYCKNVLMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N7D7</accession>
    <name>A0A2X0N7D7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C009g05608 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C009g05608</name>
        <name evidence="2" type="ORF">BQ5605_C009G05608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY82966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N7D7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY82966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="129" mass="14443" checksum="84BA40B24B8110F5" modified="2018-09-12" version="1">MWSSTTVPRPACSTRRGLTRPNWSWDPLERRPWSRREQSRGSDTSETWASRCLNPSLSSPTTASCALREAETSQVARAVGESHRQLQKDPAAEVGSSTKGGTREVPTGWRPQEEAGCRFAAWVAKRRSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N7K2</accession>
    <name>A0A2X0N7K2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C023g09715 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C023g09715</name>
        <name evidence="8" type="ORF">BQ5605_C023G09715</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ24259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N7K2"/>
    <dbReference type="STRING" id="796604.A0A2X0N7K2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002307">
        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF302">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-5 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="40"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="151"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="176"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="202"/>
            <end position="206"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="271"/>
            <end position="274"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGZ24259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="360" mass="40776" checksum="B2369C5182A77BE4" modified="2018-09-12" version="1">MGCSQSSPEQIRNREIDDMLSREKGLASREVKCLLLGAGESGKSTVLKQMALLSVGTHSNAERHAYREIIYSNAVQSMQVVVLALEDLGLPLSSSRNTSFADHFRRLDIQPDVMDDRGNLHPELRDGLISLWNEPAVRACVAQSHRFQLNDSAQYFFAAAPRIGAPGYLPSDADILRSRVRTTGITEAKFQMSERLSFRCFDVGGQRSERKKWIHCFEDVNIVFFVVAISEFNQTLREDETVNRVSEACVLFESISNSRWFIRSGLLLFLNKIDLLESKLQHTLFSDSFPDYRGRNTLVEVQQYMLSIFKSLCRKTIYAHFTCATDTHAMKVVLASVENHIIVTNLNDSVSAERDLEPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N9P0</accession>
    <name>A0A2X0N9P0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C027g10420 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C027g10420</name>
        <name evidence="5" type="ORF">BQ5605_C027G10420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N9P0"/>
    <dbReference type="STRING" id="796604.A0A2X0N9P0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002182">
        <property type="term" value="P:cytoplasmic translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05833">
        <property type="entry name" value="Ribosomal_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044076">
        <property type="entry name" value="Ribosomal_P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="62"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGZ28716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="111" mass="11156" checksum="0D1288AD5224EF14" modified="2018-09-12" version="1">MKHVAAYLLLVAGGNSSPSASDVTELLATVDITPDAERLEKLISELSGKDLNELIAEGSSKLASVPSGGAGGAAAAAPAAGGAAPAAEEKKPEKEEEKEESDDDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NAZ6</accession>
    <name>A0A2X0NAZ6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C048g12404 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C048g12404</name>
        <name evidence="4" type="ORF">BQ5605_C048G12404</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000110">
        <property type="protein sequence ID" value="SGZ30543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NAZ6"/>
    <dbReference type="STRING" id="796604.A0A2X0NAZ6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="3">
        <location>
            <begin position="73"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ30543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="170" mass="18557" checksum="558F7B651C545D06" modified="2018-09-12" version="1">MEASSRAPTQGGPQPPIGLRLGAAPNRSRADRSRPQAIASAPSTDEGEPDGVSLKEFTAFVIKMGHWASGTAVHYKESIVVAAEATINLLAPGLPLGKRFESHQVVLMADARPWHLGDRLESDGKWRIILFAGDVRDLTQRQKLDEVEAYLGSVVPIHLRITTWIPCLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NGA9</accession>
    <name>A0A2X0NGA9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C055g12659 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C055g12659</name>
        <name evidence="1" type="ORF">BQ5605_C055G12659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000092">
        <property type="protein sequence ID" value="SGZ29277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NGA9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ29277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="154" mass="17484" checksum="34C4F7AC6D358ED8" modified="2018-09-12" version="1">MFSTQEWLESDVVRVCEVGPRFRSMFQAHVPSLDVVVGENIDGLAITNNDDDGDIYLARNRTRILTRARTSTCARVRLQTPRPVTSLTPMTTSDVHVTCFHIVHMRHAICEMQLDLSQLQLDVSPRPDSDARTVRRRTTRLMTCPTLPSSTPYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NLL5</accession>
    <name>A0A2X0NLL5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C011g06524 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C011g06524</name>
        <name evidence="2" type="ORF">BQ5605_C011G06524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NLL5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="1">
        <location>
            <begin position="339"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY12496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="439" mass="48834" checksum="E1AE3D8251DBA780" modified="2018-09-12" version="1">MAVCAHCKARHWECKGRTGHFSTCCLQGKVQLPPLSGPIPSIDSYLKGRIPTRPGTQGPRMFCFFGCFYHRLAALIPTVNQRPALAQIWLIDPTEATDTRLGLDGADSRIQRSTLTKLESMLRTKNHFVREFASAKARAGWATAKERVLRLCLPPGRDRRAHNLPTSSTEMAMLICDSDTNTGDRGPQDLILQSSARSIRLRCLSGSHYYFLQGKMASTPTFLFAGFAKLGCQSPETESRSTMVSNRARYLPVSVLLTKAKRRTKTVTMRMKTAGDEKNGDGERTRQVKGSRWRVSRSQFFAHYLPNVTSTSQSRIAPNVPSWKNLRLTTTQGINGLTPNPIGRSMTLGSTFKNRPRDITQRYQDAMACVVKHGKPPLLITMTYDPDSPEIKAALGPNDKACNRPDLIAQVFEAKTGNKRHAGCFGDECRMDLFLCCTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NLM0</accession>
    <name>A0A2X0NLM0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C011g06534 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C011g06534</name>
        <name evidence="2" type="ORF">BQ5605_C011G06534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NLM0"/>
    <dbReference type="STRING" id="796604.A0A2X0NLM0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY12526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1169" mass="129573" checksum="DCEC49E2C73B0658" modified="2018-09-12" version="1">MCSVSESEQGAMNIDEGPMAVDRPNRTNKVPADRSDFEGTQSVAPEEGSCLDSEGDGTDRLSDSEWSVNYDEETSDDEGTGFHRRHRDWSDDSDSVADSNLDDDAPGRDERVRLDSTAPKEQVACLSFSDLAMYNLCKRQKVSHTAYAALVQLMQAPSFDPRALPKAFATLEKKAKSNLRQSTILQHTVPVEATDLNLTGEKQVTRTGETRVYSLSTEEQLRIKILETPHLLGRLHTGMGVHTDTRSNAWEGDVWAESIGANRGDYPVEVEKRPVEGKERERSTRMERPGTATLARRRLQTAAGERTKRHETARDGWTVETARPIPDPTWPDQIGALTKLNPIPYPTGDRIHPGCFVKYDVPDDGIGSRTFIGRIKTIQRTPSPVAAGDGNNGDHNLRHDYPRHLVIRIQRLLMADEITSYVASRLGPTAVPPSASAYCEQMGLSGSSRRRFLCLDTFDTVTLASIQKRLTGPAIIKEGDVSPPRGLFVDTLLALREIATAGSRKPSLIAAKHLPKTIAELEIEAGEIDPDILEVHRDREIVVVMALYNDAFATFRSTHNTTGGCYGDLLGLPKSDRDRMDNRLVLCFTPHGIKFDDAVAPVLEEMRRLTTDGFAHKDPSGEDVRVFVKILGGRFDLPEALKNAEVLSHGAECCCRFCGVTKEDYAAMAAGDINALERKRSQEASVQQRANISAAVPRAQAALRRACGLTGAVPLFEKAGIALDPHRQFPVEPYHLLAGLSGDRVIPAVMAVLSLEGRAIFSRVRTANPPYRMEVEGNFSRIGNPKHYARFTASDKLRFVSVAPLILALAIRETNDPKKFVNAQALPALKKSQTRLRSGKLISTHLGVLELALDTLKTFAELNSIVFDASQDYGTLLNCSAALDEAIHRISKQHEALTNRRDVCQSFLRHIVILQALSGAANGQGSARLKELMEAIRLEAPGCLRLVKGELEGTDDGVDGVLPTSDRPTALSIPQRIERIYLSKNWTQNRIEQSEFPPTLFNVATDKHRAFALSVRQAYMKSYEIALTSFATPERGKVQYYEKVVCDDRILERLVTINVGDFVCFAAPEDEPHFLYAFARVDGIMVSRSERNVPRLFFVIEWMSQKWKTLPLLGLTPVVSFKHTAEKRNKKLPRVVGPDMLMSNEKPQLFHNYTSLGLTINNPYALSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NN24</accession>
    <name>A0A2X0NN24_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C010g06191 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C010g06191</name>
        <name evidence="4" type="ORF">BQ5605_C010G06191</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NN24"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1050.10">
        <property type="entry name" value="At2g23090-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039713">
        <property type="entry name" value="At2g23090-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039438">
        <property type="entry name" value="At2g23090-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007513">
        <property type="entry name" value="SERF-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026939">
        <property type="entry name" value="ZNF706/At2g23090_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33788">
        <property type="entry name" value="OS07G0114300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33788:SF1">
        <property type="entry name" value="ZINC-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04419">
        <property type="entry name" value="SERF-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12907">
        <property type="entry name" value="zf-met2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118359">
        <property type="entry name" value="Expressed protein At2g23090/F21P24.15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small EDRK-rich factor-like N-terminal" evidence="2">
        <location>
            <begin position="7"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="At2g23090-like zinc-binding" evidence="3">
        <location>
            <begin position="42"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY14467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="82" mass="8403" checksum="609856BB725EACB5" modified="2018-09-12" version="1">MGGGNASRGAKSAAARAKAQEKLAKSGPTSQLKANAAAMTIQCVTCKQTFMNTTKVDALKQHAENKHKNAALATCFPNVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NQA1</accession>
    <name>A0A2X0NQA1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DASH complex subunit DAD3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Outer kinetochore protein DAD3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">BQ5605_C012g07036</name>
        <name evidence="18" type="ORF">BQ5605_C012G07036</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD3 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NQA1"/>
    <dbReference type="STRING" id="796604.A0A2X0NQA1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013965">
        <property type="entry name" value="DASH_Dad3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28017">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28017:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08656">
        <property type="entry name" value="DASH_Dad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="SGY16940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="129" mass="14492" checksum="1A8E4F4A335C9360" modified="2018-09-12" version="1">MASASIANAAAVHTLVARLEDQVLKEYSNVSHNLDEMSTVLQRLSSMQPYILNQFRPLERKLGLVLTLFKGTYPPLGSSVTSKRVEQRGTARQNPHLVLTDGMSHVACVYRCRVGVVGQTRRRRWRRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NR57</accession>
    <name>A0A2X0NR57_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C097g13103 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C097g13103</name>
        <name evidence="2" type="ORF">BQ5605_C097G13103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000009">
        <property type="protein sequence ID" value="SGY11618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NR57"/>
    <dbReference type="STRING" id="796604.A0A2X0NR57"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="699"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY11618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="709" mass="75902" checksum="A52CD56A8A8281D8" modified="2018-09-12" version="1">MQTGDPGSAPGARAPPPPASAPTSLPIAGTKETQATQVAGRTATYAAATNSSVVSNETPAQQQDRLARLQALPGILAAIQAVPGNRADRFVQAIFATPDFPSTVATALKFSALNATRNIINPFANALEVSLSHKSTGRASATDKGELVACVRTLLSPNTPICFDTGVPLSGDLEAFMPRITGLQHSSTFRTGVLHHRITVGFVSAEARDAALASAPMLVWNSANARFAKAHPFHRNMLEMRINVGVVRPPSKEQIVAAFQSIVQQLSTKGHSCQLVQVLRVIHVDTAKAYAHTVGDFSAFIHFDDASLFQHPTTTLKEILPSRMDLPTRGLDVTARCPLMQAANRKEAEDLARHAVMRGAGMVGGGEQTGVGRAATTTTNNIRPTANNNNTSEVVAPSRALGTDQLESRNRFAGLEVEGGQEDDIEEEVAGKEGEEKEQVKEGDEDTGAKADDEDSDSDGNAGAGIDKAGGDGKDDDKDDDEDDDKDEQDDSSEGSERRGDDVMKDGAEEEDEGMETEVEEEVEQEQGVQDDSIMIIDDGQTTITTVSRESTPRSPSWPPLSPETLAKSLREGAEKRGDHQRPTRRAGNRSFATNLQSGVRKMDNCDSINIRGTGSRSNKKMKRSQTVADLSDPSDDPVDVKARSEQGQRSSRKGGSGSRGAKAKAEKGKGVEEEKRWSDHEPEDDILPEFPLFEDNITAKSTSTSSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NS07</accession>
    <name>A0A2X0NS07_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C011g06478 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C011g06478</name>
        <name evidence="1" type="ORF">BQ5605_C011G06478</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NS07"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY12354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="153" mass="17794" checksum="B818B02CB406E157" modified="2018-09-12" version="1">MQQLPHTGLQSRTLPPHDLAKLQLYMFKRDHSLSRDAWTDLLTLLRTYAFHNADLSNISEYKMVRTIRHLTSFRTVEVGKCPKGCVSYGAKRLEDLEECPTPGFRENRFTLGKNGEKIERSTQRFYDPAPFVEAVATRTKRYSTTQLRDTQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NS16</accession>
    <name>A0A2X0NS16_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C011g06488 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C011g06488</name>
        <name evidence="2" type="ORF">BQ5605_C011G06488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NS16"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY12378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="174" mass="19259" checksum="F894FD90C64D811B" modified="2018-09-12" version="1">MALRPDSLQIYGALAQRYSHFGSLDGAVTAATPLEIGSLICFSLKCGMHSKSDNKSLQPRHARLVGSTLKCRRTGASPHQENIKDLPPFGACPACEMPLAEPLQAAQMPPRKQGAQLQQKGSLTTKQRASQQSKEGLFEAWSHAQHQPKRRAPQATFDRPPRARKRSERVFEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NTC7</accession>
    <name>A0A2X0NTC7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C016g08266 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C016g08266</name>
        <name evidence="3" type="ORF">BQ5605_C016G08266</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY21706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NTC7"/>
    <dbReference type="STRING" id="796604.A0A2X0NTC7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00229">
        <property type="entry name" value="SGNH_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34407">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34407:SF1">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY21706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="600" mass="65154" checksum="2963AE6D3828919F" modified="2018-09-12" version="1">MLHRRRVSSRYEPVTTAPTAHGNGRSSPTGLAGLFGGRSSSNSRNVGGKADRTLTPLRRLVYILIGLVAMFMILHYASSNSSTRSRFGMRGSRRTDALVRQARKQRASAAVYNAEGGSAPANFSEAPPFTFCPSYGSSDELGNKYGREALSKTRSHVGGTARVQRVIKRAMAGLPITIGILGGSISSCHGLDASPAHPLGNPIGPNCYPHRIFSWLNDVFPHPANELTNGALRRTGTSYYGFCSDMHLPDRVDLIIVEFDTEDPHDPTSLSTTDLLIRSLLLRPDHPAVIMLGHFAPQIQGEYGFAGPEIYHTTVAQFYDVVHLTVKGLIYEEYLLNPQKVRSTYFLDPILANAKGHELLADTVISFLEAQVCQLWDQVALQADIAALGGSTTIVSPLNVGEDFPSLLSGKGLRKSENVFEEADSSNSPDTGKGSRSSHSKIPPFRIGDRPHTLARFREIKPNCASANDLINPLPPSVFAGSGWSPVVPKLEEEDETHYWYTDAPGSLLKIPIKCGAGDIAVYYYKGPASQGWGNVLCWVDDNTAGAVELKGSRDRDYGQPTVTQIDQAVTKGSHFVVCELQGQPGVDHAQFKLFGIFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NTP7</accession>
    <name>A0A2X0NTP7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BQ5605_C010g06215 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C010g06215</name>
        <name evidence="11" type="ORF">BQ5605_C010G06215</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NTP7"/>
    <dbReference type="STRING" id="796604.A0A2X0NTP7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF36">
        <property type="entry name" value="LACTOSE PERMEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="310"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="497"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="530"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="570"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="598"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="181"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY14515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="662" mass="72644" checksum="700CD14F1D8D2FE7" modified="2018-09-12" version="1">MSDPTTLDAIDPDQTSTQTISTKADLEKQATHGSESSSSQAHLNPLRQRRTESIKLDNASAAPVQEVRSAALTAAVHASGKMDIRSRGEFRICLWAVLFARALVSFFRKRKRAIRATTPLLFPSLSRRSATKPWGMEMPPCLQGPPEELEERDHIASRTSTEMKETGRSCMRGPSLTLFAAIFVAFLCSTANGFDGSLMASINNMAAYQRQFNSGLVGSTTGIIFAIYTIGQMFGSMVSAPIADHFGRRVGMQVGCVAIVLGSIVATTSHAKGQFIAGRFILGFGIAITTTASPSYCVEIAPPSWRGRATGAYNCGWFAGSIPAAGITLGTSYIHSNWAWRIPVLAQCFPACVVIAAVMFLPESPRWLIAQGRGEEARAFLVKYHGNGDPTSAIVELEWSEMVEDIRTDASDKRWWDFSELFRTKNARWRSLMVGLMSIAGQFSGNGLGYFNFQIYSYVGYSNIMQFVLNLVNTITSAIGAVIGVSLADSVRRRPILVWGTLACAFWLAMNGMATHLWAIEDPTAHNLNIGRFAIASFFLFNIVYSFTYSPLQALYPVECLQTNTRAKGMAAYAFFVSCVSFINTYAIPIALENIEYNLIWFFVGWDCIEAVVWSFLGVETQGRTLEELETIFSAPHPVRASKANKQAAIDERGNTIIEALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NU28</accession>
    <name>A0A2X0NU28_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C010g05956 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C010g05956</name>
        <name evidence="3" type="ORF">BQ5605_C010G05956</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NU28"/>
    <dbReference type="STRING" id="796604.A0A2X0NU28"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016833">
        <property type="entry name" value="Put_Na-Bile_cotransptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18640:SF5">
        <property type="entry name" value="SODIUM_BILE ACID COTRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18640">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 10 MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13593">
        <property type="entry name" value="SBF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY13727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="490" mass="52764" checksum="1D55F8743FADF58E" modified="2018-09-12" version="1">MTQATPLEPPLMQDSSSKPDTAAMTAQPTSRASASSLESSPSQSQIRVGGRTETGTCDSDDSATLTEPTSSPPSIKERRRNAVVWIGQTMLHQWFLIGIGIVIGLAHSFPNVGREGGIVHAQWSVNYLLVAIIFFVSGLSLPLHKIVKRARDYKLHLVTQAYSFLFFPTVVYAIVNIVRAADPTYTKINEWALVGMVVMGCVPTTVASNVVMTGQAGGDESAAMIEVIFGNTLGVSLTPALLNAFMSGPWAFCAPRTSGSGGTADIYLKVLKQLGFTVFIPLVVGEVLQSVFIHQTQWIRTHCHLAKLSSLCLLGVIWSTFSGAFYEKVFTKITGGTVAFIVLVDIGLFAFHALFLMLLARHTPFLHLTHSTKSRFLPTFSASSPHETLFDPSTTIALIFLGSAKGVSLGGPIASIMYGAESAEHQSLVKLPLVLYQGSQVALGQGLVVILRAWKRRVDRRDAVALAGEKNVDGEVVASKDGEKDLESSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NUJ9</accession>
    <name>A0A2X0NUJ9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C010g06116 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C010g06116</name>
        <name evidence="2" type="ORF">BQ5605_C010G06116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NUJ9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY14244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="125" mass="13142" checksum="BBCECBD37B3F8451" modified="2018-09-12" version="1">MAARTSSALWAYLFALMVVGPGIGLTFLPEATCVAFNLTSITSSTLHLSRLIGVRNIVFGVMLLATPRGSTEYRTTAKLVALTEALDVGIGYLSYHHGDMAAKDAIQSSVAAGVTALIGWKVLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NUN5</accession>
    <name>A0A2X0NUN5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C018g08731 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C018g08731</name>
        <name evidence="2" type="ORF">BQ5605_C018G08731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY26400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NUN5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY26400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="244" mass="27674" checksum="4B45589E93DA829D" modified="2018-09-12" version="1">MTSPNKAPFDSTTRAASHYTTSHGLQTSGVATSLPAARTSQSSDIPSSRVNTTPKRTSSVTFTPPLLDEPAQVLQRGPRTVETDSNDGASHFGSAGADVRLNALTEKATHDVRILQTVIHDHKHHHETEYVTRLRDLHIHHHHIQHHVQPLVDDTSSKEQHHYQSMPVQEKFEQRTNSPNDLELWALLNKQRHTETQTCHERIVIQNGEQVHETVHYHVHNIIQPVFYRYRPVPSVCTNPNVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NV71</accession>
    <name>A0A2X0NV71_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C012g06840 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C012g06840</name>
        <name evidence="2" type="ORF">BQ5605_C012G06840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NV71"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY16311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="149" mass="16471" checksum="EF14D5D9DD47A69B" modified="2018-09-12" version="1">MRAFNSPFLQTPVALYPRSFNLAPVFDPISSYNFSPSAPREVLQFPRLLKACPGFHELHDPQFNAAIGIIIIIVTIQSIVVYSYPSLLPSFHTPISIYLISASSTFFNTTCLPFNPTLGFLLNNPLACNKTPRCRSPKVVASSIVLTPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NXP9</accession>
    <name>A0A2X0NXP9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C015g07976 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C015g07976</name>
        <name evidence="2" type="ORF">BQ5605_C015G07976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY18089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NXP9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY18089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="153" mass="16595" checksum="8F14C54154D79B99" modified="2018-09-12" version="1">MPLGSNRPFPEHPGKHCAAGRRDQGILRASRRSKGSPCRASVAYDQKTELATQVSEEGASMSATFVSEIRSSASTSIDSATTSRCRGPDLARCGPTLTEKTAVRLRYDPSTPCGYSDSCASSWCRDSSLRDVLRSKGSRRRPTRFGRDSSAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NZ56</accession>
    <name>A0A2X0NZ56_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C017g08533 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C017g08533</name>
        <name evidence="1" type="ORF">BQ5605_C017G08533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY20216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NZ56"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY20216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="48" mass="5651" checksum="A7EA56A26B5DDC78" modified="2018-09-12" version="1">MCRKGHPVKLRPLEIEQIRLTRGDSIVFLRIVKPLTLHSSWQVFSHLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P006</accession>
    <name>A0A2X0P006_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C019g08923 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C019g08923</name>
        <name evidence="3" type="ORF">BQ5605_C019G08923</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PET191 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY23279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P006"/>
    <dbReference type="STRING" id="796604.A0A2X0P006"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018793">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_Pet191"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28627">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28627:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10203">
        <property type="entry name" value="Pet191_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY23279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="87" mass="9797" checksum="C630814E243FD6F8" modified="2018-09-12" version="1">MSCNGVRTALAECLLKSDCVLKSEPPRTPHECLQHHSDALPIECQQLRKAFFECKRGMLDMRKRFRGIEPASTKVSPVATDERGRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P1S0</accession>
    <name>A0A2X0P1S0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C002g01429</name>
        <name evidence="12" type="ORF">BQ5605_C002G01429</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. BUD32 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY32977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P1S0"/>
    <dbReference type="STRING" id="796604.A0A2X0P1S0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000201">
        <property type="entry name" value="TP53-regulating kinase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209:SF0">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TP53RK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209">
        <property type="entry name" value="NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY32977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="411" mass="45951" checksum="09441F5383AB4458" modified="2018-09-12" version="1">MRFKSLRRFQMQISNAFRLVRARSFARRLPRLSRSDDDRSSFPLAILPCHHERALPSPPAHNLRSMASLSSKQAEADPIINPTPTPRAAHPIQHLLQSGRLIKQGAEAKVYKTILFPTPTVTQPLSSSSDSITDPTLSHLEPTSVLLKHRFPKQYRHPTLDLQLTRTRLTAEARSLVRCLKAGVVVPALRLVDTNQGVLGLEWIEGNSIREVLGGSKEEDQIMQDDEHAQHDSIEELWRQRVADLRPFTITALLLTMIGENLAAMHLANIIHGDLTTSNMMVRQVETLAENDPPYQVVSAAAGVLGLDIASAALIEDVDSFFQVLIDFGLSSVSPLPEDRAVDLYVLERAFTSTHPVPLLESGQEGEPHFTRVLQAYMAKMKKDGKKDEGLRVEKRLNEVRMRGRKRSMVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P1X9</accession>
    <name>A0A2X0P1X9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitotic-spindle organizing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C002g01568</name>
        <name evidence="8" type="ORF">BQ5605_C002G01568</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Required for gamma-tubulin complex recruitment to the microtubule organizing center (MTOC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MOZART1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY33908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P1X9"/>
    <dbReference type="STRING" id="796604.A0A2X0P1X9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000931">
        <property type="term" value="C:gamma-tubulin ring complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031021">
        <property type="term" value="C:interphase microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033566">
        <property type="term" value="P:gamma-tubulin complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051415">
        <property type="term" value="P:microtubule nucleation by interphase microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022214">
        <property type="entry name" value="MZT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520">
        <property type="entry name" value="MITOTIC-SPINDLE ORGANIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520:SF2">
        <property type="entry name" value="MITOTIC-SPINDLE ORGANIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12554">
        <property type="entry name" value="MOZART1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY33908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="87" mass="9292" checksum="D40D707907C6098A" modified="2018-09-12" version="1">MSLRRAPMGVIPQSPDEQRAQAARESLDILLEMSTLLNTGLDRTQLALCIKMLEDGVNPDALAAVIRDLRAEATGKTIGSTGSLGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P2H8</accession>
    <name>A0A2X0P2H8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C007g04368 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C007g04368</name>
        <name evidence="10" type="ORF">BQ5605_C007G04368</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY59987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P2H8"/>
    <dbReference type="STRING" id="796604.A0A2X0P2H8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF3">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="28"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY59987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="480" mass="52043" checksum="1E4B38878C82E37B" modified="2018-09-12" version="1">MQTIREKLANGLEPIRPSRRRSNMEIARICLSYGMNFMFGISAAAIGSNIPSISAQYHVSFALLSTVFLTNRVGFFLACVLSSYLMHNFSVRATLMCGNAFWVMSCLILLLQPSFALVVLAFTGMGAGTGLTEPAIVTVITREQSPVLTSCLYSSFAFGAIFSPLINGSFADRNILWTNFFYIPLGLCVLLSIANVFIFRTYEADLLKAEQEELRRRTVVNFAIRYPTRPETEGQDRRKSLFLSTSAVKNTHPEAREDGLTSEATHSSSTSSKPNATALLLRVLRHKVTWIGFALIVLTMSEGETLGGWSTTYFLQVKHAPAGMSRYISSGKWTGNAIGRILLPIIFLRLLGEKTFAIVILLIACGMQLIVALLPSWKASAIASAFFGFVIGPITPHVLSMVGSRVPSDLMAPAMSLMLANGVVGGAFGPMLFGIVGASKGHLNALPFVAIGLLGLSALGWLFVPRKKEEGVMAVGGDFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P481</accession>
    <name>A0A2X0P481_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C003g02430 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C003g02430</name>
        <name evidence="3" type="ORF">BQ5605_C003G02430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY40840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P481"/>
    <dbReference type="STRING" id="796604.A0A2X0P481"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053245">
        <property type="entry name" value="MitoProcess-Associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47563">
        <property type="entry name" value="PROTEIN FMP25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47563:SF1">
        <property type="entry name" value="PROTEIN FMP25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="411"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY40840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="664" mass="71498" checksum="E4112B1E5BAE224D" modified="2018-09-12" version="1">MIRPTSMLRFGTSSFLGSARAAARSPGAAPLLRAPPQLRRPIRTFLALTATTSTLAIGYALHQSTNEPLYARSSEPERGYESQSQSQLHRGKLGSISPSVFLWGRNEHNVASPQTPESDMVKRPKLAAQFTGAILRDLVLAETYGAAVDEKGDVLQWGSGFDSSPVATATPRPTLRGYDVLKLTATPHKIFALTRKGEVIVFPSSSERQQINEEQRRSNSSWWKVWGSTDHGTDHEKIMPEQALAKGEKFVSLSAGESHLLALTSTGRSFGLPLDLSANVFGQLGVRNVQLLSLHSTSVSSGTVRVKLNPDPTLNEVRRELPAPPTRIDPLLLPPGATELPVIASQPIAPVSRPRRTGSDVRLHDDESTQQAMEEDIRFSTVLHELPALREIEIAELVAGARHSLARLSDGRVLGWGANGYGQLGLGASLSYPSIPAPTEIPLTRCYPKAVRVTCNRIAAGGNLSYFIVDAVDIPTMKQTIDLLATGNGQFGGIGNGSWAHQASPVKVKTISGLLEWSEEMGKVAPIAIKDISVGNAHIALVLDNAVDQGGVKFGRDVFVWGHNFYHQLGTGKRSNLSTPQHLPPLPYAGLIAPPKRTVASVEGATAMEQQPENERTMGSGTLSPMPHSRMQLAPEIKVGKKVVEEAIVAGDGGSAVYWRILNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P566</accession>
    <name>A0A2X0P566_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C004g03081 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C004g03081</name>
        <name evidence="2" type="ORF">BQ5605_C004G03081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY69948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P566"/>
    <dbReference type="STRING" id="796604.A0A2X0P566"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058353">
        <property type="entry name" value="DUF8040"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF259">
        <property type="entry name" value="OS08G0106900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26138">
        <property type="entry name" value="DUF8040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8040" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY69948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="163" mass="18695" checksum="2CC608CBE05A9DD9" modified="2018-09-12" version="1">MTPACFSIFVKKVLLHTEIVPSNHVTVEEKLAMLLYWQRGAESYRKIDEVFQRSLDTIARHLPETLGLLVHSDLRKLHVFQPTADTPTSSVITDKPRFARYFGNCIGAIDGTHAPYKTQDILAAMTFELRSCYLQTRCEGSAHDQQAWDWARERDLLIPEGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P5J0</accession>
    <name>A0A2X0P5J0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C005g03223 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C005g03223</name>
        <name evidence="6" type="ORF">BQ5605_C005G03223</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shugoshin family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY72877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P5J0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045132">
        <property type="term" value="P:meiotic chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011515">
        <property type="entry name" value="Shugoshin_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07557">
        <property type="entry name" value="Shugoshin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shugoshin C-terminal" evidence="5">
        <location>
            <begin position="626"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="158"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="482"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="291"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="345"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="394"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="424"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="488"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="522"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="568"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="588"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="662"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="698"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="719"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY72877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="738" mass="78763" checksum="3812F21773E3F562" modified="2018-09-12" version="1">MTTRRLSGASSAGNNGMGPMIEAYDAFKKKHMQQNKEIIHKNSILSKSNSELERTVTSLRAERLALKGTLFHLECENSNLRMRLQQTERQLNEAREAVSAGISPWDHEQLQVGLPHRLCTLSSPRMLSLIIRWCRQMTQRLYVNALAALQALGNGLPSCSSPMSDGATSDVPCSPPPIPSSTVLHPRLSTVTESPPTPSASSSSSSSGDANRNVTVSRRGSTAGRAPRPSSIILQRNPDLSHISEGGEQSHFNDDEEDDSGDEEQMKSAWKGTLLDGLREEPRAPASPSVSRPPTPIFVPPPISSPLSAPLSPHSETSTTTYSSQLFASTSAPTARPLPSKARATHSAPPAARSAHANTSSFSQQKPARRVSGIVKAPTPEPQPGQLGAVRSDAPAATTPASTTTGVTGKRTSIVGQLGRKSVSTSSLAATTSLTSSSGAKKATEEEDYWSDRKTLLKLESLGPKEMLAIVGSRRKTSTLAAVEANLSSSNKDTSTTSSTSEDDERVGESISTQTQQKRYEDEENSYEVDEQSSDEEFVPSKKLVEAALGKARGKRRATRAGSQEVAQEVEQEQDYDYEQDGNFGSAPVSSASQPRAMPSSSAPPVLQSNTMLANGGHEEGDAGGRRARKSVNYALPKLNTKMRRPEDYVPVTNSHPRKSSRPSVATVSGATSHILRTKSSLTSLRGRASMANSENEAMSDLDEEESSLAGRNEKEGVSKGGNGSGGGVTARRHTLMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P6G6</accession>
    <name>A0A2X0P6G6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00675 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00675</name>
        <name evidence="2" type="ORF">BQ5605_C001G00675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY48638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P6G6"/>
    <dbReference type="STRING" id="796604.A0A2X0P6G6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048661">
        <property type="entry name" value="CPL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038955">
        <property type="entry name" value="PriA/CPL1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192:SF2">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21671">
        <property type="entry name" value="CPL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein CPL1-like" evidence="1">
        <location>
            <begin position="458"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY48638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="536" mass="55409" checksum="3CA0F957353DB590" modified="2018-09-12" version="1">MNCGKASKVCPSMGWRNGNGEPVCLNNLCGTNCNGGYAFSWPLMTCISTKNDTNNCGAIGTVCSSSNASRNATALACVDSICKATACSPKFHVEDGVCVKNINTTSDMNNWQVYNGTVGVGGVCSNSVCQPKSCNTGFAFNYATSKCINIMTDNSNCGAVGKVCSFPYGSGSCIAGTCLLSSCNTNYYNIKGICTYIDLTSNSNNCGAVGNKCSFSNGLGKCITSDCTYSSCSNGFASINNTCVAVDYQTDMNNCGSSGNTCQSTYLNGGAGLCVQGQCFSVCIIGYTWDATHSICRLTSSDVYNCGAIGNICSPLGSLSSICSNSQCYASACLPGFELIAGVCYKIDATSNVNNCGAVGAVCRFYPVGASGVCTNSKCVITTCPAKYSLSTSGVCVAAAVSQRPRVAKRKVVKRTPCPKGETPCPIKASASFELAVTQHFTVPHDEYAGIFTGLGGYECLDTRESLESCGGCSSTGEGQDCTAIKGALGVGCDNGSCVVFSCKEGWKPNARGTKCIWANNNAQPNATRNAAAAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PBP8</accession>
    <name>A0A2X0PBP8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C004g02985 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C004g02985</name>
        <name evidence="2" type="ORF">BQ5605_C004G02985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY69279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PBP8"/>
    <dbReference type="STRING" id="796604.A0A2X0PBP8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42103:SF2">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42103">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY69279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="104" mass="10988" checksum="F1C6FB89DC0E4040" modified="2018-09-12" version="1">MSTSRTYPYTEEAYATLPRSSPSTDSSPTSSQPSSLLSYALTHPTSDPPTRLALLAHPWGRLGGSKDDHVVVGVMNALVKEGYAVCRYDARGVGGSVGVSATWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PDT8</accession>
    <name>A0A2X0PDT8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C020g09170 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C020g09170</name>
        <name evidence="2" type="ORF">BQ5605_C020G09170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000082">
        <property type="protein sequence ID" value="SGZ18190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PDT8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ18190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="100" mass="11166" checksum="9291A20F32586B52" modified="2018-09-12" version="1">MTLKREEVESNSARRRGQALEVTDQTRRREWGLRAKAWIRMKEEASSVARKRVGLVKAELTSRNSGTSCIGISPVDNFCANPTNFSGSDEDVRPMIAPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PES3</accession>
    <name>A0A2X0PES3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C022g09562 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C022g09562</name>
        <name evidence="9" type="ORF">BQ5605_C022G09562</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PES3"/>
    <dbReference type="STRING" id="796604.A0A2X0PES3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34072">
        <property type="entry name" value="ENZYMATIC POLYPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34072:SF52">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase RNase H-like" evidence="8">
        <location>
            <begin position="30"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGZ22937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="180" mass="20220" checksum="A299026978B662B9" modified="2018-09-12" version="1">MDHLKSLFASDVILRYYGPALPCVIESDASILSQTVDSQLRPIAFFSRKRTPAEQNYDIHNKEQLAIVACVKIWQCYLEGMHHPITILTDHSSLQYFQTTQILTRRQARWSEAINHLNYIIKYRPGTPNNKADALSRRPDFAAGGKACEQPEIAATPDCSQAFPPAAKSGRRESASALLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PET3</accession>
    <name>A0A2X0PET3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C008g05298 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C008g05298</name>
        <name evidence="5" type="ORF">BQ5605_C008G05298</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY80080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PET3"/>
    <dbReference type="STRING" id="796604.A0A2X0PET3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328:SF15">
        <property type="entry name" value="BHLH TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328">
        <property type="entry name" value="PROTEIN MAX MYC-ASSOCIATED FACTOR X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="4">
        <location>
            <begin position="520"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="225"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="274"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="602"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="345"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="411"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="461"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="495"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="635"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="645"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="670"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="724"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="740"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="764"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="782"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY80080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="807" mass="85531" checksum="7EFF27A9C3F17094" modified="2018-09-12" version="1">MHASSSTSSASAIAPVRLPPVSIPRDDELLPPPATGFNSLRRVSLSDPFLHAYPQSGPGPNGQGAASSGSGMDPPSPTSVNSQQTGFSAKRRDMDDEGEAKPLDPNGRGPPQQPYAEGSRSGSPTHPYHGHSQANYGGYGPGGHFIQQQQQPLSQQHLSHHPHHPQSQSHLYGSSHSGPAVPVSQQQLGPSSSYRFGGPTPIGPSQESGSYFDYSMRRHSLSTNGILGAPGLASATPSSPTRRISAEAASGNLKRKQSGEGVIHEEGGYQHAGAYAYSGNGSNGIMPPHQINTQPPPPKRRGSSLTHDKMGNLSLAEQQARRDSGMSSQSNLSSWEDDRRGSGGSWTSAGSQGYSMSSYPTDPYDQRGPPHGLPNGTYDSPRGSVSDTTYTGDPTTFGRRPSIGISQLVQGGSSSYGGPPAYARSLPPVAHSPPEENRDSPHSVHAMAPDRGGPYLTSAPAGPPLAPPSGPWRPAPGSYNEPHRDSRQSSTGSLGPYGMGMGGDGDPDNFKDSPYARSPELRVTHKLAERKRRKEMAHLFDDLRDALPVDRGLKSSKWEILSKAVDFIQQLKATNVELGKDNARLRAHVGYGPGSIVGTWMPGGVVNSPPPHPPHMQSPRMSISAPSHPPPPMYQNHTRQPSDYSSQPVSAQSGASSAAASDFSGEHAHQQQQQQHSKQQGQQHQHQRQQQQQPSHQQMQQQMQQQQQQQQHHPHPGQSRHGSYQHSAPPQHQRTTSTMSLASDRGSSSPSGARGGNVGDSGSMMVSDQSDFNGSGVGANSGVKNASPLSNSSVTFAPTVDATTVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PFX6</accession>
    <name>A0A2X0PFX6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C038g11682 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C038g11682</name>
        <name evidence="2" type="ORF">BQ5605_C038G11682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000061">
        <property type="protein sequence ID" value="SGY91583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PFX6"/>
    <dbReference type="STRING" id="796604.A0A2X0PFX6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY91583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="275" mass="29580" checksum="3342E9F24252A8D9" modified="2018-09-12" version="1">MSAWCTCRPLAAASARSECIEENWATGAKVSLKSMLSRCRLPCATSRALCPVISPSAFRFVFQTNLDVTMVAPVGTVKRSLMVKTLKSLHMELNSSSAALAHTSRLSLDIASRQVCGSLVMDLTDWIMRQSPLLSGEVDCRTEVMYFSVPMRQSPLLSGEVDCRTEVMRGKLKNGKGARTGIGPVAGEIARALRQLRASKPSRAPKSPPQGGGLAGVRDDRGASVELRVDSSHGWPQLAPNEVEFVGRLLSQCGLAVHAELGAVHVRWVEANPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PGR1</accession>
    <name>A0A2X0PGR1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C027g10379 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C027g10379</name>
        <name evidence="1" type="ORF">BQ5605_C027G10379</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PGR1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ28577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="76" mass="8126" checksum="BCFA186FF1E9C9E3" modified="2018-09-12" version="1">MHFAKASLSLGINVITLTNHFVAAKSDAVATPELCGKGGRKKDPVTTLICSDASSVCRDIKWSVVASRNRWIPLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PIQ0</accession>
    <name>A0A2X0PIQ0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C028g10458 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C028g10458</name>
        <name evidence="2" type="ORF">BQ5605_C028G10458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000080">
        <property type="protein sequence ID" value="SGZ11800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PIQ0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ11800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="261" mass="28737" checksum="FD82C3DE8F9A449F" modified="2018-09-12" version="1">MIGRVQSKPPKRYTPKEEKDGPSLCVVGQETKGAEHVGHLPDEPVLLEKLPNDDGIDLPVSLIERQPIASELWTRINATESGRAECEDIPALEQDTTAIGADDVDNFVSTIAFTWPCTAAASDKAAAQAYKELASQCQDTSAYYPLNFQIETFAVIGSSCVERKEDRAFRCSAGAEAFSERIGWLGTDQELDIVKRFTKVVTGHAAFEESIIWYCQLVQQAFGECSGALQTQRAQEDVGMPSNPKTWFNRPKLLSQDDCPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PLT1</accession>
    <name>A0A2X0PLT1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C025g10072 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C025g10072</name>
        <name evidence="6" type="ORF">BQ5605_C025G10072</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000087">
        <property type="protein sequence ID" value="SGZ27172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0PLT1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019783">
        <property type="term" value="F:ubiquitin-like protein peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="5">
        <location>
            <begin position="258"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="482"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="496"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="514"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="544"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGZ27172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1618" mass="179036" checksum="1493C9FAB9C9DE7A" modified="2018-09-12" version="1">MKICQDPRKPSRRRNFFFFDILRTQNPENRRGASQKIDILGRNIPYGIALGPFAFASKRASRCSRLNKSLAFFANHFSSVAHDEMIPCLFLDEDQDYYLHDDDFDRLSPLTNMTVAELLAFDVAPADASLHIELSKDEPTQYSNLPYPTLQTRDAFLATDALINARKKGYRSLAVGSTCLPLGADRLWSEYDRAKDVQSWALRAQRWMDKIIVINEIDRNRIAVARRILNGLQWQEQDGLLPLPLLASGTSLVYLLRFLSQQLAYSRLYPGHDWLGEAAVNLSIESVLRAGRVQNPDFETSYGLIPSTVISLVMARPPDSDPHSVFKACFFGPPNQYRNLIELGDCMRNTPTSKSIWFLPLCSDSHWVLARINMHKRTWSVINSLSATPITAATRTAVLTLFKFLKLDIKNEFPNTPKAEQQEDSYSCGPATINAVETEVLGIGSFNAARAHISRLRQFCRLSSLVGAVEDPKEIESIVATGAKSKAKSGRGSAAGTLSSKSTSAESGKAATIKPTNQRVASSSKNPPTSRLQTTFTKASKPTKARELTPEEHTTWARDHPPLFRRFAEKVEDLCPGSNVDVNNPKYVRCGRCYVLKCVNLQPISNFFRPIASGSTATSPSLGPCPGLTSETAMYYLSSTAAQGGGAPPRRTLCLRLYPKIGKRPMTELERKEVDKLEANEWKWRNDHRAPRIISVNCRKYSARDSINKDGPSLPCEECARLPKDSSCRAALRRQYAAGATRKYTNKKYVAGDTLLSAIYRRHHGLEEILDDNGQGTVYLRFAQGVASGEFDGANILEGLVKAATVKHDRMVKGKSMRGFVRSEALRDFEQAMALASPMALRVLQATIGASTSRKLQMRLGLDKSKVDRVCAKLEADGLTFNLHVDDTKCRSRMRTTPYYSEDLSLERELRTKGIFRHELIGSIGPPRIYETPGELPDMFSGPDPPVAGTKIRAYMIAPNDVGSPAQVFAAFVIGETTNAEDATEQLHSVIQELIKRCVAHLLVSISADGAASEGVLQRNVAVLLRDQDPDGVFPEITISTVNVAGTPIVFCRDEKHLAKCLRNAIDSGARLLFGGLGCIAYQDMLTILGGLESCRTLSLRDVTKNSTPMRSCISSYVASYTMPSRTGRFSPLNVSGCCSLSDIRSRRGMTLSEVAPDLALTHSSPKKRLMGSGRWLTQRLLSSATTEIFGRRNRSFPGGMAQKWWSTSSGVYARLIRQATGKVTALLELMRKFKTEAAGSRQGYHHTYNDLDDLDLVAMRTYPSLRMWEPVQRIASNRRNQGSQPDILVEDVLAHGTTVQGSSERLGLQVMHHHPTKEDQGRLRTELLDSALDGMRRSTCQGVVKLDPNEREAVDRAIRSLAALDFDVEAALLDVQIAYDEAEERYVLETIEKANSSLRPIFLAEWASLIAHRAAHECSHLRAVLLKGRPMELSDTSRGEAGLEISNTEQGRSAVHSRVLKGLVQSMGPSRFEDIAGTARSFRWTGGGQVARALTTNEIQKNAYIEDGRIQEKLPERDKQYGALAQSYPHFGSLDGAVTAATPLEIGSLICFGPKRGMHSLSCDQTAYGEEALSIGIGTFDNKPLQPRHARLVGSTLKCRRTGASPHQENMLFHTPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PLX6</accession>
    <name>A0A2X0PLX6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C026g10133 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C026g10133</name>
        <name evidence="2" type="ORF">BQ5605_C026G10133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ27580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PLX6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="487"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ27580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="587" mass="65362" checksum="03E08DF8AAA3B495" modified="2018-09-12" version="1">MYDNEDIDELYNFYRQRSEQLPIKIPAGVRDSSSCGPNPQGQAENFSATTWLSPVQRPVEADPLVLWTRQEAVAALKRAQPLDPTSSGKEKAQTPKLRLPFVLRTQSGKMVLNLKFKDRVSYARDVDQGKKLVARLIRSSWSHDNILEGLKTVGPLLRLCSASYKAHVWLGDILENLRAQCRPKLVAFLEVNPGFKVHGKRIPFTRRVKPKENNSGGRNGGARSSQGEQVRLVFVFRAADTDACTPVKQLRFDPEEAEMCEEEQEEEQGSEGEKERAGTDYDDDDDEYSETMRLAEQTYPTLPNARLCWLGDTGADDLSRDLQRLLNSATELCRYDKTFSSTQKHVHPHIEKFAQDLAKLQLSAETNGLNRDDLDNGGAQFGHGKLGLTELAETREYLANWPNWSIRDVVTRRWNCIAAIARDEFAHVRRKGKATARNGDDGQTLAKVKVGYIFRAAMVPTVQDVMKTVEQALDEHKKETRGEVESESATTSSNTSRSKRPAGATGAGSSVAKKRAKLTDDATLQQLPSAIPDQINKTIATPLAKKHGRGNLPKHASPKTVATQPVSKTLGRLRVPASDTEYYGQSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PN00</accession>
    <name>A0A2X0PN00_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">hydroxyisourate hydrolase</fullName>
            <ecNumber evidence="5">3.5.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C050g12498</name>
        <name evidence="11" type="ORF">BQ5605_C050G12498</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23736"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="ChEBI" id="CHEBI:58639"/>
            <dbReference type="EC" id="3.5.2.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.17" evidence="5"/>
    <dbReference type="EMBL" id="FQNC01000097">
        <property type="protein sequence ID" value="SGZ29757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PN00"/>
    <dbReference type="STRING" id="796604.A0A2X0PN00"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033971">
        <property type="term" value="F:hydroxyisourate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05822">
        <property type="entry name" value="TLP_HIUase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.180">
        <property type="entry name" value="Transthyretin/hydroxyisourate hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014306">
        <property type="entry name" value="Hydroxyisourate_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023418">
        <property type="entry name" value="Thyroxine_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000895">
        <property type="entry name" value="Transthyretin/HIU_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023416">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036817">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02962">
        <property type="entry name" value="hdxy_isourate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395:SF7">
        <property type="entry name" value="5-HYDROXYISOURATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395">
        <property type="entry name" value="URICASE AND TRANSTHYRETIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00576">
        <property type="entry name" value="Transthyretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00189">
        <property type="entry name" value="TRNSTHYRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00095">
        <property type="entry name" value="TR_THY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49472">
        <property type="entry name" value="Transthyretin (synonym: prealbumin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00768">
        <property type="entry name" value="TRANSTHYRETIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transthyretin/hydroxyisourate hydrolase" evidence="10">
        <location>
            <begin position="266"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="20"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="161"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600895-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGZ29757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="380" mass="41889" checksum="65834B091388AE94" modified="2018-09-12" version="1">MEFDTAGLFSNQSQDAAFHSTFHHHHQQQQQQQQQQQQQQQLEQQQQQQQHHPGDLQTGLGGHAGDVSSPEDNKKVCHRSPWWSMYQPLGLRLARALQQRGSGRPRDKIWEMYKGEKTATCIYCEWTTDHPKAVRLRQHITEACNHVPPLKKEQVQNWEYDKAQKRASKKASVGGTGTGTGTASSSPMKKEPEDAASAAIRAHQNGNAVAGPSGSGSNGKKRRIEEDLVPIAPPSTSSNQEIAVDPGLEGFNALDNALTQTMSNLHRSPVTCHVLDSTAGKPAPGIAVKLEKLNPSAGFVVQATGATDSDGRCSNLLPAHPRLESGVYKMTFYTSDYFMARGIHTFYPFVEIPFSIANPEEHHHIPLLLAPFAYSTYRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PN42</accession>
    <name>A0A2X0PN42_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">BQ5605_C026g10262 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">BQ5605_C026g10262</name>
        <name evidence="18" type="ORF">BQ5605_C026G10262</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ28049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PN42"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="17">
        <location>
            <begin position="110"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="356"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="SGZ28049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="954" mass="105429" checksum="472C2104879E8A8F" modified="2018-09-12" version="1">MVAGKPRESDRNSWKQVEAKGIYKLNASVQTPSPGAIHTLVTTKSHGIPLLTLHRRYGHASVQTLKKLAASGQVEGLDWTYSDLECVGFTCNACLASKAHRLPFPPSSFHASEPLALVHSDVLSFPEESFSHKRYLVTFVDDFSRKTWVYPIGHKSEVLQTFKNWLMEIKNETGHRVKTLRSDNGGEYVSTAFNGFCVARGIRRELTIPYTPKQNGLPRTCWDEAAMCYIHTKNLSPHAALKGGVPNCRWSGSPPTVGALRAFGCRAWATVPAHCRDKLDPKGIPLVFVGYNRHAKAWPLLNPSLMRVSLSRNVTFLETEFPFIAVPARVTPPSVPGFYPRPPPANALATPLPPVLVEPTQPPSLDDDATSSIHLPQRPPEPAPPETTPLAKFKPTWEYGDVAKVGPNPEKYGEIDARNIIAGPRTRRQLVPTLITWEDLVGGPDGPTPAFQGMLRAFASTKAGFAEHYLSVVRDPANWDDVIRSGQQDTWGGPAHNEFDSLLNKYEVFEVIDSCELPAGEILLRSGWVFRTKRNQHGDIIDCKTCLVAHGCAQCPGIDFEQNYAPVVKFTSIWALIALAVANGYHVHQADVNKAYLHGKLDKPLYMRIPQGIDMPGKILRLSKSIYGLCQAGTIWNAEIDSTLCSLGYVPTQSDICIYRREHDGHSHYVALYIDDLLLVGPSTAKIDRVLDALELTYGIKRLGPAEYILGIQVKRGHNRFQFADAKPASVPMQPGVVLNFENSSATPEDRTRYLQAIGSLMYAAVGTRPDLAFVVSYLARFSQQPGPEHWTAIKHVLRYIKGTLDLGLTYRKTNQPLHGYSDANWGACLTTSQSTMGYAFILSGAAIAWCSKREHRIAKSTTDAEYLSLLYASGDAIHLSELLSELGAPVPGPVGSRHVRISEHYIRKRVAEKEIEVRYIATGNMFANIFTKALGPKPFIFHRTNLGLQGAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PP33</accession>
    <name>A0A2X0PP33_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C053g12598 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C053g12598</name>
        <name evidence="4" type="ORF">BQ5605_C053G12598</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000098">
        <property type="protein sequence ID" value="SGZ29867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33116:SF86">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33116">
        <property type="entry name" value="REVERSE TRANSCRIPTASE ZINC-BINDING DOMAIN-CONTAINING PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="913"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ29867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1530" mass="168695" checksum="51BA69E62FF9216E" modified="2018-09-12" version="1">MTADILTKPLARNLFELHREGMGMVSLGALTSGSVLFFSLLHHALNGRRRLEKGNSYWMDNNNNTNNASHAAIPPLRPDPPDPPGQAPATTTKSYSAAVGARSAAKHGNATANASTAVAAHPLMHNIENCVIINTPPSTSVEQVLLALDKYYHASSRTLCKVEKLYSSTRGGVVQCTLTGFFSDPEGLCLFDEQIAAYGTVLRRRIQYIGKTKHISGVYNFILALRMITGGMRHCVFCRSVAHVCKDCPVAPACKSCASTSHATQHCPARHASSPQGPPTSRAPQASTVTTAAPAAVSKSISPASAHDRTTKKRRVEQDLAAQTEDLSNRAQPDSLSKNARPEFSFNFPCKTATPPAPQPASNQGIAYSLVEKSSESPSSETTSPSPSPPPATPKSIMTRSKSIATLSKPATREAPPTAPALEASELSPEPSSPTPLPSAAPKARPDDADTNDKADEEAEDQEAPPKDSTNEDRKCASLFSNLRSHNADVFLLSETGRPSPERVAQWTQECQDLKLSALFTPFNNTAILWKSNSVVIPFDPESPPNTLRASFSFPDRVTDATFCVGDSKVRVVSIYAPSSDKPDKKRFLSHLSTTLRQVVRDKPSPPALLVGGDWNCIESQPLDSENQNGTNYGGQEMRNLATANNLFDAYRLHHPKGRATTNHSAPGTCRRLDRIYVLPDWVNLFHDHKIWAPVLKLTHSMVVARFQVPGAIDIGPGKFKLGLHMIEGDATCEYLTSIVRTLYNKALLQTPNDPPAAWTSTKHRLLPELQALARTFARFRRGGSEQERADHSRYRAAVRSRLDPSLAGPSSIFIRLRKVRASDLIPSLTVNDVVHSDPDSMLGAASDYFERVYEDRPIDDAALKAIIDGLASTRLSPADSLKLEEAYPLEEMTKAQEAFLCAVGLGPKARQWYRATYTNQSASIFLNGWLSATFDILSGVRQGDPLAPSLFVLAIEGFACQIRLRVKGIDIAGLQNVRELLFADDACCALHNLSDLDHLNRAIELYERASASKLSNVKSFLYPLGAFRDRSIAPDLGTWRLSDSQFRYLGIQVGVEIAEDAGWEDVKASTIARICSIPMYDLPYAAKCSIINIYCYTKILYYSRFLPAPKSVVKEIKEAAMLAIHGRASDGTQRRPKVSRSRLCTPLDHGGFGLIDLPQRLAINHAKWVFQLRAPDGCFTRHLFNIRIRLQAPNEPTPFTLSRPAPNQHCCPWIWIWWAYFCHPPPKWDHAVRKTTKLLPAHWVRYFEAWALVTTLNPPELSKSQNLEQWATHVLYFPVGHGIQLSENPTLFRGPDGEVMTLSSFVNASKRHQVFIFPLIFPKGHQKVFNLPEQRWNAWWKALRKVRRVHSDAEDTGHLLSLGSLHPGSQVASPTSPHPNNRSTSCVMCLSEAPECLVHLAVGCPFAQRLWSALSPTPHPVFVDFVCPVVSRSERRLVELRVLFFHSIWKLCRRRRFSSDLLEPITETEFEGLRASIQESKGRLVSLGAGARVLCGGPAEAAGCLHEIASFWPSCFSLFSTTHSISHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LPR3</accession>
    <name>A0A2X0LPR3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="21">BQ5605_C011g06673 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">BQ5605_C011g06673</name>
        <name evidence="21" type="ORF">BQ5605_C011G06673</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000003">
        <property type="entry name" value="Transposon Tf2-6 polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032549">
        <property type="entry name" value="DUF4939"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16297">
        <property type="entry name" value="DUF4939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="11" id="KW-0229">DNA integration</keyword>
    <keyword evidence="15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="12" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="20">
        <location>
            <begin position="379"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="20">
        <location>
            <begin position="1710"/>
            <end position="1871"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="18">
        <location>
            <begin position="2016"/>
            <end position="2065"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="19">
        <location>
            <begin position="3070"/>
            <end position="3249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="635"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="2072"/>
            <end position="2095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="2382"/>
            <end position="2410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="2719"/>
            <end position="2762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="2851"/>
            <end position="2876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="647"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="683"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="2719"/>
            <end position="2729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="2736"/>
            <end position="2762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="2864"/>
            <end position="2876"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="SGY12988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="3466" mass="386891" checksum="CF9523D08F8F1C46" modified="2018-09-12" version="1">MSLTDLPAADVNTMAGPDDRASTPPPSSTSTQSQNIDVSAIGSITLTREQYEELVRYQRTRDEEAPTPRHLLPPEAPAAFPEDSKLKGDNYVDWDITMSLTVDREVCAYLRRGTIDPTWTPTVRSRWQDYALHVLARSLTPATTATIGPVVERGGSAHDCWLALTARYAPSDAQGHSSLIMNYFGMLQCPSTWKGFIDWSNRALVLINRLQMAQLNMEQAMAARAMDNLPPLFDSWRTTFYALQADKNKLPRAEDIFASMEAADVQTKSAAPGRKGKWDRSGLTPSNCPVCGQGKHWVDKCPDSVKCTKYFKLKNAMKELKGASLAPAPALAATKKLAASGQVKGLDWTYSDSECAEFTCNACLASKAHRSPFPSSLSHAAEPLALVHSDVLSFPEESINHFRYLVTFVDDYSRKTWVYPISHKSNVLPTFKDWLLEIENATGRRLKTLRSDNGGEYISSTFNGYCAARGIRREVTIPYTPEQNGRAERLNRSIVEGTLALLSHSGLPRSCWDEAAVCFSHTKNLSSHAALKGGVPNHCWSGTAPLVTALRAFGCRAWATVPGDRRDKLDPKGIPLVFVGYDRHAKAYRLLDPTSMRVSLSRNVKFVETEFPFLSMPKRATAPSIRGYRPIAQPMLQPEGSRATPNQLPPPNDELPPPNDELPAPDHEAASVRSDATDAAEVLPPPEQVPEPPAKVKPAWEYGDLARVGPDPGKYGEVDPRNIIEGPRTRRRLVPTMIAKEQLDSGPDGPTDAFKNLILAFAATTEGFAEHDLAMVRDPANWGDVIRTGQEEVWHPPARDEFDSLLNDYEVFEIIESCDLPSGEILLRSGWVFRTKRNQHGDITNHKARLVAHGCSQRPGLDFEKNYAPVVKFTSIHALIALAAATGYHVHQADVNKAYLHGKLDKPLYMRVPQGIDLPGKILKLSKSIYGLRQAGTIWNAEIDSTLRSLGYIPTKSDICIYRRDHNGHSHYIALYVDDLLLVGPSVAEIDRVLDALELMYRIKRLGPAEYILGIQVKRGQDGSITLSQERYLRDLLDKFRLGNAKPASIPMQPGVVLDFQDLSATLQDRTRYLQAIGSLMYAAVGTRPDLAYVVAYLARFSQQPSPAHWTAITQVLRYIKGTLDLGLTYRKTDVAFHGYSDANWGACLTTSRSTMGCAFIYSGAAIAWCSKREHRVAKSTTDAEYLSLLYTSGDAIHLSKLLAKLGHPVPGPVVIYGDNQGSLALAQHPTNHQGSRHVRISEHYVRERVAEKEIDVVYIATADMFADIFTKALGPKPFLFHRENLGLRGAVVLVSYYCLILSIVLEHRCTRCFHSSTMCPFLDTFVIVYLDDILIFSKLEDLHRQHVRQVLAKLREAQLFAKATKCEFYQDSVEFLGYVVSSQGIMMDTSKVASIHDWPTPKSIKNVQIFLGFANFYRCFIKGYSALAHPLTHLTKKDVPFESNDEALQAFEQLKLAFTTTPILAHFQPGVQCTLKTDASDFAIGAVISQPVDGKLHPIAFWSRKMLPSELNYEIHDKELLAVVLNQRQARWAELLAHYNFEIKHRPGTLSGKPDALSRCTDYQDGTKASEGSPVVLLDPNSFPELLDILVKTQESDPTLRQIIQNFAEGKYLDTHDHHWGIQKDCLLWNGKPFVPNNTRARLAVLKATHDAPSAGHSGIEKTLDLIKREFWFPNVKQFVTNYIATCDLCQQSKTCRDRPHGLLQPLPIPNGPWQSIAMDFIFKLPKLIQGNDSIFVVIDRFTKMGYFIPFKEEGATAPVIAYLFYQFIVSNHGLPKDIVSDRGSVFTSDFWRCLCQLTRVKTSLLTAFHPQTDGQTERLNQIVEQYLRLYTNHRQSDWEDLLPLAQFAYNLMKHLSTRKTPFFANYGYHPTLDLTLPSYSSKTQNVFASNHYDTLRDTHALMRYNLAAVIAKMERSYNKTRSENPEFKTDDLVWLSARNIESVRESKKLNFKWLGPFKILTTVGRSAFRLDLPPSLRVHDVVHVSLLRKYHESNIEGRIVPPPPVTLINGNDEHKIETILDSRTRNGALQYLVQWRGPLSATDPQWVRDYILDHAIDLVKQFHIQHPRAVKSAPHRVSSRSGAQLSKEGVTPGTPCQDIASPCARFLSASLLSPTIFTIIFGSRTYALHASASAHQRRATSTSTVTWHQRLHHCHPTSNHTNDVASATSVTLTKEQFDELIRNQRPAWDDDTFSMCQLLPPANPPVFPDDSKLTEDNYVDWDLTMSVTFARKVCAYLRKGTHDPSWPLALRSRWEDYAAHALAGSLTVTTKATIGPIVQTGGSAHKCWLALAARYAPSNAQAYLALIKDYFSMPPCPPTWAGFNTWTHQAMVLVNHLRMAQLDLEQAIAAQALDDLPHIFDGWRTMFYAMNVRNNRLPRVDGNSKTVAPTTGAAPGKKGKWDRSGPAPSNCPACGQGKHWLDKNAMKALQGASPSTTTTFVAAAESSKDQDLCHEPVILQFLARFTGGWPYIVPSCPLLSEWILYLFEVSLVLPTSVTMSSNPISIEELQAALAARDAALASREAEIASLHAEGHALQQTYQAVLDNFNIVKKLTDTLHHTPKPKSPLEKPTAYDGKDKTAYSTFVSQCKFYIYGNPTLFTTDEAKIAFMISLLRNSAYKVFEPYIELADEKRPHFLKDFPAFLEQAQLYLGDPDREHTITNNTFFQLSAFLAWNDPALQAQYYAGLKPDVRSMLSLQDDPTSVADLSAKAIKADNRLHQSRQEAKATAKPHSQHSQPRGNSASPPTRVTTNGTTQGPTHMDNNLCLYCGEGGHQHFEKLERPLPSCTHEDITHAHGIARSPPSPVYITLASTLDTQPFDHLVRPRCSLTTLSCLVMASFAAPTRLQSHSSSSTAAPLRPATSPTSFASRSRSEDTQVIQADVTQLGTYPLVLGTPWLRLFNPSINWADNTLTFLCSQCTLGHPTSVDVSLQGLPLVHSAPDLALEVALVSSDAFDQSLVDEPYLGLINRDPAHSYLFSTSEEASPSVFPVGPPDSAEYLDDLRSALPSEYHHLLQAFSKAQADTLPPHRPFDLAIEIEDGKQPPFGPLYSLSEKELQALSTWIDENLSKGFIRPSTSPAGAPILFVRKKDGSLRLCVGYRGLNAVTLKNRYPLPLIPEALDRLRSARIFTKLDLRSGYNLVRIKGGDEWKTAFRTRYGHFECLVMPFGLTNAPAAFQHLMNSIFRDLLDVTVLVYLDDILIFSDSPSDHVVHVQEVLRRLIDNRLYCNPKKCEFHQTSTEYLGFIISPDGVSMSPSKATLASSRLTRLLKKGAVFDFDSLALAAFNRLKSLFASDIVLRHYDPSLPCVIESDASDYAISAILSQSVDSQLRPVAFFSRKMTPAEQNYEIHDKELLAIVACMKLWRHYLEGVHHPITILTDHNALQYFQTTKVLTRRQARWSETVNHLFILEADCLETCCAVEGCAPLFLSFAQWQSLFLDVGSASRVNRFWRLSTFPFSLQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LQB0</accession>
    <name>A0A2X0LQB0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C010g05983 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C010g05983</name>
        <name evidence="5" type="ORF">BQ5605_C010G05983</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LQB0"/>
    <dbReference type="STRING" id="796604.A0A2X0LQB0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23645">
        <property type="entry name" value="HFD_Dpb3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF54">
        <property type="entry name" value="CHROMATIN ACCESSIBILITY COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="4">
        <location>
            <begin position="29"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="122"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY13813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="188" mass="20224" checksum="D62FDC20FB3AE09F" modified="2018-09-12" version="1">MPPEKPAPAPAAEASTSSNGPRIPAGTTMLPISKVHKIIKADKDVRLCSKEAIFLISKTTEYMLGKVTQQSYAQARSQKRAKTVKYQDLATVAQRPEFFYLSDVVPHTLPLNKALAIRQKMQEAAEGEGEEEIDPDTVLGGEKAEDDGGEHVPEDGEGESGAASSPNVVEEEEEEEGSEDGAGMDVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LSZ7</accession>
    <name>A0A2X0LSZ7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C011g06322 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C011g06322</name>
        <name evidence="2" type="ORF">BQ5605_C011G06322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY11924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LSZ7"/>
    <dbReference type="STRING" id="796604.A0A2X0LSZ7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY11924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="562" mass="63644" checksum="0FB5FACF45C5CE91" modified="2018-09-12" version="1">MQLLSSFFRKRSADNTEVKCSSWQSYLGQGCNKQRILIDLWHFFDRIYVSKKHGAAKAFARAFSDAVFIPNADDRLLMEARLAKLGMTWEEAVRSPVWNKKLWRRVRRWIPPPGILEPLVREVFEKLGDSERPSIGSSWHRAVHRPWALRGPDGKADDGVRLYSCQRDTNSLEGGIHRNLRQRFPKSGVSPSHVNACMADYVLVHNLTVSPTPPSQFEETATILTHYPLYSQVGTFNRTGKPFVGHYDLWLTVELHRLRRKTSAFFPRHSTTVSDIVNPLLYTPSTETFGIVPVVQSPTAHMRFLIEPYHVERGTLRLEPVKWSPRNLLQNNTSAIQHMQSRLLTDRKLRHDWLAERQGTRFAVLHVHTPSERALYRYLSSKVRLGAPQNRRIFEITEPWNKYANGLDIFYKMPEHINTWASRWSSLANAQATMNMGGNDVRVIQALLTDPSRGRDVSMLAAKPLLGHKPPVLGRLTEIEVDASDPPTSSIRPFVATASSDAGSSADLGTSSALTRAGTTKGARHCRFCGQTTCRLKGSKPSDDGSTRWIRTTHNHEGSVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LTS0</accession>
    <name>A0A2X0LTS0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Defective in cullin neddylation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C011g06602</name>
        <name evidence="4" type="ORF">BQ5605_C011G06602</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LTS0"/>
    <dbReference type="STRING" id="796604.A0A2X0LTS0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.200:FF:000003">
        <property type="entry name" value="DCN1-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.200">
        <property type="entry name" value="Cullin, PONY binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014764">
        <property type="entry name" value="DCN-prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042460">
        <property type="entry name" value="DCN1-like_PONY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281:SF31">
        <property type="entry name" value="DCN1-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="RP42 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03556">
        <property type="entry name" value="Cullin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51229">
        <property type="entry name" value="DCUN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DCUN1" evidence="3">
        <location>
            <begin position="66"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU410713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY12787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="270" mass="30975" checksum="6353DA01FE008F9F" modified="2018-09-12" version="1">MSSSKAARETRVREFIDITGASPQEAARFLKATSYRLDAALEAFSNDPTAMRAAEQQRLSGGEGGISIRNLDKLWDKYRDVEKPDEIHFEGTIRYCEDLGIAPEDIVMLAVAWLTKAPTMGHFSKKGWTDGWREARRDTIELQRAYIDRLRADLHKGDTFRQVYAFTFDYAKAEGQKSMQYEIAQELWKLLIPSDPAADFPTSHLDLWLEFLQTRGERPVSKDTWNLFLDFTRTIDPLFQEHDEEAAWPSVIDDFVDFARHSLACMAQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-11-27" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LU93</accession>
    <name>A0A2X0LU93_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C010g05939 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C010g05939</name>
        <name evidence="4" type="ORF">BQ5605_C010G05939</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LU93"/>
    <dbReference type="STRING" id="796604.A0A2X0LU93"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016661">
        <property type="entry name" value="PFDN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100:SF9">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="89"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY13669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="195" mass="22422" checksum="1E0427C681F0A523" modified="2018-09-12" version="1">MRPGRQSQSRARCWVRSEKWRFYADAHDQALQDPVIVCSPTLPYHGCLLIRCYTQHAHGQPILDQDVSDSTANDDTPVTLEDQTRINQFSQLNARYDELTERLEVVQKELEDVEELEPELELMDDEEEVMYKLDSSFLRLPASEVLTLLQSSLEKLNAEAATLRSEREECDQGMTKLKGLLYAKFGNSINLERGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LUX1</accession>
    <name>A0A2X0LUX1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C017g08430 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C017g08430</name>
        <name evidence="2" type="ORF">BQ5605_C017G08430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY20005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LUX1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY20005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="279" mass="31203" checksum="A03BE3A5ED63E51A" modified="2018-09-12" version="1">MLLPLVHDQQLCKSTEGATESIFDSAESYRKNIHLKFPSVDWSEARLVVEGEDEWGMEYLCAPQLVPGLPCLSASSALPMTAEELQEHLDREEAGPAETSDIAPRRNRHLFVDSGGNKWIRAGVVYVQELLPAYLQFEDQDGERCFYTKTARIELRMTVACTEDNPRISTRSDFDRKELGGQGAQVKASIGRLNLGASESQVGRLDQEIVEGSRDKLRKTPEEAPPRSSRRLSIGGYPVPSGCPPSRHAPPSYQERPFERHRPSEFCWPLCALKAVHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LUZ1</accession>
    <name>A0A2X0LUZ1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C017g08450 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C017g08450</name>
        <name evidence="1" type="ORF">BQ5605_C017G08450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY20058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LUZ1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY20058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="171" mass="18640" checksum="E251FCD7D4AAFB5E" modified="2018-09-12" version="1">MVAEQSMCFIGPLPAEIGQSGICDDVRSTFGAIALREVSLLGAPCVLSSASASSPRFALLGTEIFVGGRRLPQQDRSQQRNTPKQYLLLYLTYSTFSSRRGPCQTPPELLRLPDAEKDHRYDKPSFDIGTATTSSQVPLGLHESRTTSLGYSSSMRSVIFIRPSLYFGNSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LVV0</accession>
    <name>A0A2X0LVV0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Dynactin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">BQ5605_C012g06843</name>
        <name evidence="15" type="ORF">BQ5605_C012G06843</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="13">Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3. The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3. The 4 DCNT2 (via N-terminus) bind the ACTR1A filament and act as molecular rulers to determine the length. The pointed end is important for binding dynein-dynactin cargo adapters. Consists of 4 subunits: ACTR10, DCNT4, DCTN5 and DCTN6. The barbed end is composed of a CAPZA1:CAPZB heterodimers, which binds ACTR1A/ACTB filament and dynactin and stabilizes dynactin. Interacts with ATP7B, but not ATP7A, in a copper-dependent manner. Interacts with ANK2; this interaction is required for localization at costameres. Interacts with N4BP2L1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Stress fiber</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Myofibril</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the dynactin subunit 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LVV0"/>
    <dbReference type="STRING" id="796604.A0A2X0LVV0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008603">
        <property type="entry name" value="DCTN4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034">
        <property type="entry name" value="DYNACTIN P62 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034:SF2">
        <property type="entry name" value="DYNACTIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05502">
        <property type="entry name" value="Dynactin_p62"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="483"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="483"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="500"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SGY16319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="564" mass="60453" checksum="8F8EDE24F4E8F925" modified="2018-09-12" version="1">MSSDRVLFHCPCCEPVSVKRPPPSEAPLSTFGHHELSSLLFCEECDAIRCSTCVAFEIACWYCPTCLFEVPSASVRGEKNRCARNCFQCPQCSHSLSAVPSDPDPSHPPASAAASIGEAPYFLACTVCRWDSKSVGIIFDKPTGLAQQLQKLDDGSSELTEFDRLKDHFEPYIRRGQAHASASTTTGALAPSTMPASTSSTIASSVLKDIPGLGNRYAHLLGGMGTRSGKGAEAVNGARDELEPYEALVPAKGSVEKGKGVERDDELVREMESLQDFEQVAALEKRWTNSWDALELRGVMTDSLRPLRTLLQAKRSKRCPICKHILIKPEQKAASTRFKIKLVASNYLPSIDVYRRPPATIGSRLSAIAAGTASLRRAGPRGSGIGASISGPKGMVEMDEEPLRPGRTYTYELSFTNPLYESIQVRLAVARPTASTKAVGAARTDTGADPGVSTLATAPPPYAVNLPSGYFPISAYAEEWEFEDDDQRMDSDDEDSEESAGGGGGGEGGDAPKSKRARNAAMGIVERKMNRTTVAMEVAVGRETVGPIKVGLNRSMGSTCGAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LWK3</accession>
    <name>A0A2X0LWK3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C012g06944 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C012g06944</name>
        <name evidence="4" type="ORF">BQ5605_C012G06944</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family. NP60 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LWK3"/>
    <dbReference type="STRING" id="796604.A0A2X0LWK3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF8">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE NADP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="2">
        <location>
            <begin position="18"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="3">
        <location>
            <begin position="192"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY16671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="363" mass="38410" checksum="2D6AC76D92DCCEBB" modified="2018-09-12" version="1">MASSSSETCEISPRDQLKVGFIGLGNMGSHMAHNLARWLSANDYPALSLWNRTSSKLPPVSNSIAHAESPMAMAEACDIVITSLKSDSVAQEVYAQLLEGAKKKDKSKGTIFVETSTLYPTTAGELERAASAIPHSYYLQCPVFGPPPMAKEAKLVIVLSGPNWAKKIAEPILVPAVGRKTVDVGSNVERAAAFKLTGNMLILGSIELLSEAMTLADKTGVGSDLLLSFVKDFVPAPSWIGYGTKIATNSFEGDSGFTVEGGLKDANHLRHLAASVDATIPVIDVAHRHLITSRAHGGSQLDWSSLVSGPRLAAGLLPFTGQKSFPKDDGFGSKVEVGGRYSDADTEVEAPVKSGGIKTVQNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LWT9</accession>
    <name>A0A2X0LWT9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL27m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C012g06882</name>
        <name evidence="5" type="ORF">BQ5605_C012G06882</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LWT9"/>
    <dbReference type="STRING" id="796604.A0A2X0LWT9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000020">
        <property type="entry name" value="50S ribosomal protein L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00539">
        <property type="entry name" value="Ribosomal_bL27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_bL27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018261">
        <property type="entry name" value="Ribosomal_bL27_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00062">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL27M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00831">
        <property type="entry name" value="RIBOSOMAL_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY16474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="194" mass="21236" checksum="C2D8409C94494DC0" modified="2018-09-12" version="1">MLRSLFSSLVRPSLSALPSTSVIRSSFIATPLPGLIQVRTATKRGGGSSKNGRNSIGKRLGVKRYAGQLVSAGSILVRQRGTTFHPGQHVARGKDHTLFALVPGFVHYYADLVRGKERRLIGICTEGREEKLPRDVKEMGRSRYFGLVDVERARGDWEERVQEGDELRGLMQEAVTMGLAGERSTGTSEGKVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LXA9</accession>
    <name>A0A2X0LXA9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C086g13017 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C086g13017</name>
        <name evidence="1" type="ORF">BQ5605_C086G13017</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000037">
        <property type="protein sequence ID" value="SGY28473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LXA9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY28473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="47" mass="5294" checksum="D2701093B81FCD4B" modified="2018-09-12" version="1">MEWARGVGPGVAKLSGWWTCPIATWKAIEAFVVRPLKEPHGAKYRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LXF7</accession>
    <name>A0A2X0LXF7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Valine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">BQ5605_C015g08018</name>
        <name evidence="17" type="ORF">BQ5605_C015G08018</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Val) + L-valine + ATP = L-valyl-tRNA(Val) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="3"/>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY18246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LXF7"/>
    <dbReference type="STRING" id="796604.A0A2X0LXF7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00817">
        <property type="entry name" value="ValRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000009">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000078">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000005">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="entry name" value="Valyl-tRNA synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02004">
        <property type="entry name" value="Val_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004349">
        <property type="entry name" value="PRK05729.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946:SF109">
        <property type="entry name" value="VALINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="VALYL-TRNA SYNTHETASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="15">
        <location>
            <begin position="144"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="16">
        <location>
            <begin position="793"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="SGY18246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1103" mass="123969" checksum="FA36DD916BD1FECB" modified="2018-09-12" version="1">MASNDPTPASVATPAQDGAAAPAAPSKSSLKKAEKEAALAAKKALKKVAGLAPPVAAGQGKKKEVKVKEAAPEEPPFIEVPEGHIKAGYNPVDVEKSWYSWWQKSNYFVPALPSKNPTEHSHFDPNPDFLPRDEHGQIDFDRLDKERTFVIPMPPPNVTGSLHIGHALGCSLQDILIRWHRMKGYTTLFVPGYDHASISTQSVVEKRLAKLEGLTRHDLGREEFLKRCMAWKEEYQGRITKQIYRLGVSCDWDRVAFTMDPALSKAVAETFVRLQEEGIIYRANRLVNWCVQMNTTLSALEVDQKVLTGRTLLNVPGYPTSERFEFGVITSFAYPLEGSDEKLVIATTRPETMLGDSAIAVHPDDPRYSHLHGKFAKHPFLERRIPIVTDAIAVDMEFGTGAVKITPAHDPNDFEVGKRHDLEFINILNDDGTLNANAGPEFEGMKRFHARNAVIEKLKQMDLYVGAADNPMSIPVCSKSGDIIESVMKPQWWVSSKTLADEAIKRTRAGELLIRPQNSENEWYRWLETIQDWCISRQLWWGHRIPAYFVNIEGKEQDRLSSESWVAAKTVEEAQQKAEKRFPGEKFVLEQDEDVLDTWFSSGLWPFSIQGWPDQTQDLKAFYPSHLLETGWDILFFWVARMVMLGIKLTGQMPFNEVFCHAMIRDAHGRKMSKSLGNVIDPIDVIEGASLDALHAQLRVGNLVEKEIVVAEKGQKKDFPHGIPQCGTDALRFAMANYSAGGRDINLEILRVEGYRKFCNKLWNATKFALTKFEEGYVPPASEKPTGRESLVEKWILQKLNRATASVNATLTERHFMKATEDMYSFWLYEICDVYIEAIKDITAVDAPQEARRSAQDTLFTVLDNGLRLLHPVMPFVTEELWHRLPTRPGNETQSISLARYPEPVSDLKFQAEKDFDLAFAAIRASRSIAVSYNINSKLQIIFNVRDNAALASTLQAATKALRPLIKGCEQLTIVDNEAAIPEGCVGELVSPELATNVMLKGVVNFKQEIAKAEKKKAFQEQAAQKIRDGMAAPGYEEKKPQHVREKEAQKVRALQGPCHYQLSDRVSVLIRSDRGVLLQLSELAVEIEAITKSIEGFLKLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LXJ1</accession>
    <name>A0A2X0LXJ1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C014g07433 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C014g07433</name>
        <name evidence="4" type="ORF">BQ5605_C014G07433</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY18666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LXJ1"/>
    <dbReference type="STRING" id="796604.A0A2X0LXJ1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF444">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13975">
        <property type="entry name" value="gag-asp_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="557"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="144"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY18666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="642" mass="71647" checksum="5C8511E2196CE432" modified="2018-09-12" version="1">MKKIETDVDKIDTIGQLLLDPELKVWYSSDAASHVNKKYGTGDYREFSTAARDLQLELGVSLVSDTQLVRMLLLHMDEELSQRLRLSEVIKGTGLSPDELNASIVKADSTTSSAVFDYQTFDAEARRLWQVISATRASAKATAQASARTVRSTPTLRTTASPSTLPPLSSKTRAPPMTDRERAFLRSNQGCFKCRKINAGHFKDTCTTWATSACKVPAGWRQGPVSPEQVASLSDTVDEIDNKGEELHCLCDDEYDNGTDDERCKPISLSVKLTTEDGPALRALVDTGASASFIADREVEKLRLTRRKLQVPTSVSVAIQSHRVSHPVTEFVCVPLRTLNGRWSTQHVVLKIAPLTSLKVVLGQPFLKQHDILVDCKRRRVLAPDPTLPGKRIDLMHRGEKGEWSESAVQASIRACLAHLEEQQAEESQLQALEVAFRKEFSDQFPADIPPVSQYESKVRHCIALKPGMKTPRQPTYSTPMCWRAVWRRLLDEHLAAGHLCPSSSEYSSPAFIIPKKGMDTDPSIMPRWVNDYRILNAATLRLESNLVPFKDIPKTAVATPWGLFKWVVMPMGLSNAPATHQHRVNEALSSLIGKSCFAYLDDVTIFSDTMEDHQTHVKEVLEALRRADLYCSPKKTELFRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LXQ2</accession>
    <name>A0A2X0LXQ2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C014g07464 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C014g07464</name>
        <name evidence="5" type="ORF">BQ5605_C014G07464</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY18757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LXQ2"/>
    <dbReference type="STRING" id="796604.A0A2X0LXQ2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057402">
        <property type="entry name" value="AIM3_BBC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25459">
        <property type="entry name" value="AIM3_BBC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="32"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="111"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="264"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="339"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="596"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="649"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="691"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="770"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="817"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="885"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="702"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="713"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="776"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY18757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1154" mass="122509" checksum="C536044A94932906" modified="2018-09-12" version="1">MAEAISDVDVDRYGLLRSSGRVSFPYLVTRSQFPFKAVALSKYKSAPGAPKLAFLQGDELTVLNRDDDWYEGTTISGQTGYFPVEAVRQLEDDTPAPSGEIASPALATRVESVASPLPSSSDPPGPTTLSLTPPTTHRSAQRPEPRITVPNVVDPFSEEQPKPTSLKDRIAALNAAGAGAVAPPPVRPKPRELKRSTAPVPLADGVRPESPTTGSPVLSPVISVTDSSVKSSVGLSAEDAAEAIGKGGGSLKDRIKALQGIQMSTPAAPGRAPKPRKKTSVNTAAGSELERAADSPALALQYSESDEAQRAAVRESKSMEPSEAVRAFVDAGTRSCANSVADPDAHAGARTLPPENEQHEYRVSTKAKLERSSSDVDAPQRPPVAERAAGIGDQQFSMAMPALPKRAVPPRRKPPVVKPAPDDGVSDVVVEASSAGPVATISRGETLEISAPSLLAGDKQSYGQDDSYMPETDPNTVASEHDVLSENAAEESSNCTKSNTPAVPPNTVHVASDSPAVSSFRNRISPDLSLSASRIWSLLNAEFAPRPQEKYTPLPGSGLALTQGPFDTTVFTSPPSRQDDPFTRDLSSPLSIAATSAPTIDDEQKLPSPQRPAIPQPFVVDCIEHPEDNTVDGDNHSFTKVANLEATIQPSTQQLGSDEVGLEDEAGEAEAEVRNYLLQDVPDQRVIEETQDPRGFHGGAGAHDKEPGRAKEEEGEDNDDDEEDPELARRAALAARMARLGGISMRMPGGAMMSPIGGIRSYKKPVKAMTKDDSHSGQQLSTDGDDVSCNQSATEQSFVPSPFLGIPRGGVAISGLGVRPAPPPVDSEDISAATPTDEVGGSQAFKRLQALEELSIRQNFEQLDDNPRGEETCSDTGAISLPERVEAVPDPSVHAVPDPPPRPRGGLPSVSAQPTFSLEDISELAVPSSPQVEAETQMSSHRDSVASLDRIAIRSSLGSRPAGASDSLRRGSIESSCDVRSLSSVQLSWPAVPRSDLEEFSITLGAQVFAAAHLKLSEKRVKFSNDDELIRFCLHRVKDVQWPGDGSYGVTVWGIAVLGKGLNDPRIANLDEPRAGDIVIMTDCKFRATLSSTRVGADGQPKKSVCQAWDAKKRKLRTIEVGKNGGVEENSFKVDDLKEGRVEIQRIVGAKPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LXU1</accession>
    <name>A0A2X0LXU1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01103 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01103</name>
        <name evidence="2" type="ORF">BQ5605_C002G01103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY29970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LXU1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY29970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="248" mass="27037" checksum="ECE77C0EA20D1DE1" modified="2018-09-12" version="1">MTNDRLDCNITGDPKQCLPVTLNGSVRWSDRRVGRKTEAMPSRYSTARFGGVTIALAEDPKQCLPVILKSSPTQIVDACIMNVDFCGDLSVSDKHASSGRCKPHDRNGTGKGTGLCRLALRSSELETGRRTKQKTIALPREEVEYFRERAKLGVGHINDMVLDLLPHCYRWTTARILIVARRLGGLKISNDIVNGKGCSSPSPAFAKSRQISPPPGDQGKMIALDNRLHPSQRPMSSAVQLVTAACGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LY78</accession>
    <name>A0A2X0LY78_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C014g07674 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C014g07674</name>
        <name evidence="3" type="ORF">BQ5605_C014G07674</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY19533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LY78"/>
    <dbReference type="STRING" id="796604.A0A2X0LY78"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="2">
        <location>
            <begin position="394"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY19533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="598" mass="66286" checksum="10589DCE6E5790D4" modified="2018-09-12" version="1">MYQHTVVSAAPACGVHVPIRSHVQALWSPGRAIATSPSLGREDSAVPWASSSARCWAPRGSTLLFVPLRSTESAPRRVMTTSQPILALRHVYEPAVQLRVRRARIALKPLKPHVSIRDDLGPQTAVCTHCKARHWELGPPVFRVFGRLYHRLGALIPAVNQCPAFAQTWLINPAEATDTRLQGPDSAETRIQSSTLTKLESMLRTGNRFVREFASAKPRAGWDTAKEWILRLCLPPSRDRRTHNPPTSSTEMAMLICDSDTNTGDRGPQDLILQVHGDRCPDGRPKYQIVSSLHPSAMPLRYPLLFPAGEDGFHPNIPLCGFNQAGPPIARNREQIDNGVQLRELLDGLGPDEEDEEEDDEDEGDEEDEENGDGELSRSQYFAYHLHERDDYFSIPHATQRITDAVANGLTPDQIGRSVILGSTFKNSPREITQRYQDAMACVVKYGKPSLFITVTCNPEWPEIKAALGPNDKACNRPDLIARVFEAKLNRLCDDVFGNKQRAGCFGVVLTHTHVIEYQKRGLPHAHILITLAPDDHPLSTEAIDKMISAEIPDPSRYPDLHETVTKHMLHGKCGGNSTQPCMEKDNGSTACSGAPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LYH5</accession>
    <name>A0A2X0LYH5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01366 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01366</name>
        <name evidence="2" type="ORF">BQ5605_C002G01366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY32459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LYH5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY32459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="101" mass="10451" checksum="9499FDF1E3D663B1" modified="2018-09-12" version="1">MSSGANIPNSSSSSSSGTNVFGSLQTAYLAKNPISGGIPKAGFLRRGSNKLALKTPTPSLHQAESEQAGPLANGSYRFESNNNPTLTLTNGIEDSHYGINP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZG7</accession>
    <name>A0A2X0LZG7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C017g08484 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C017g08484</name>
        <name evidence="2" type="ORF">BQ5605_C017G08484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY20136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LZG7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY20136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="313" mass="35536" checksum="F0FFE9F4CA29E9DF" modified="2018-09-12" version="1">MSEQDDDLGIEFNDVGDARMNVIRSATEAELLHNLLYAAKLSELRLLQKTYTELFTKTSGASSTSPVDQADRITSSSAPKGSNSSLFTLRRQPPHVKAAILWTREETNAEKPANIDDTGIAPKAKHKLRFDFILRSEDGEMILKVLSPQRVLYERDLRQGRKLLTRFIQSKWEDNTIDVRSLYLKHLQSGYFTSIFAPAISILESLEHVGPFLKFRHPGRKPPFKKSNKHGAGNANQPIRASSNQQETKDDGWADTPDGEDEDQGGNKEDSEDDDQETDDECYNEARRLAYEAYPMVRRGEHFVKRVLLFHPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M264</accession>
    <name>A0A2X0M264_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01292 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01292</name>
        <name evidence="2" type="ORF">BQ5605_C002G01292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY31964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M264"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY31964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="109" mass="11359" checksum="C45EA0F63C283955" modified="2018-09-12" version="1">MSAKQGRRARAIASGQSATTSTGDSDGSKGAGALAQVYKMFTMSGALEDLVREVDGGGPGSVEHSKKRRRKAKQTRRRHKKGRKATTPSTSSGTSQNSTETASDAMSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M2A2</accession>
    <name>A0A2X0M2A2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BQ5605_C002g01090 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C002g01090</name>
        <name evidence="11" type="ORF">BQ5605_C002G01090</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alkaline ceramidase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY29862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M2A2"/>
    <dbReference type="STRING" id="796604.A0A2X0M2A2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008901">
        <property type="entry name" value="ACER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187:SF3">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05875">
        <property type="entry name" value="Ceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY29862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="383" mass="43642" checksum="DD0975579C4AE5A5" modified="2018-09-12" version="1">MGHEHLHRTIWNHEDIGRTGYWGAATSSIDWYVFSASSRRSDSQATPRSPLRFRLGRPSRTGARAEPSRAEARCASTAIPRRCYSGRQNLSKPAKKIISCFTTSGCEANFIHTRYIAELYNTISNTFMIFAGFYGVYKALQHRLPKRILLSYLSLSIIGLGSAMFHTTLQYAWQLGDELPMIYTSTLIAWLIFDITPLGQKTPWLPPLCVVVFNVTFTLMYLFYPNPVFHQVAYGILVVSMTLRGAYLILYKMKDNTLARQVKHLQAWGTASFVFAFAIWNIDNIFCDSTWAPLKQRVGAPWNVLLEGHSWWHIFTGLGGYSIIGALTMVTLSLRDDPKHYRLNFKYGCLAWVSRTAKGWEVLEAGKKGTERSRLLRNGRRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M365</accession>
    <name>A0A2X0M365_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00393 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00393</name>
        <name evidence="2" type="ORF">BQ5605_C001G00393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY46166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M365"/>
    <dbReference type="STRING" id="796604.A0A2X0M365"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="665"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="952"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1017"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1124"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="569"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="666"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="681"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="717"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="790"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="899"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1060"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1083"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1136"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1218"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1242"/>
            <end position="1258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY46166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1267" mass="137442" checksum="A9397695A44866B1" modified="2018-09-12" version="1">MLSLSDLIHDLSDSEDEPDRSTLMARLAISDRPAIEGMGSSRLGVPLQSSAERCGTDQGQRAGQQDWGLSSVTSSPWHEEYGSFYEPASDGSNGGDGAGGEVDLLEHGHPALAGQHHEHSDHLMQLSPLEQLTSMMAYGDAYANATACGRISLPLSPTTPPPRSPHPRGPRRAEPEPRPSPLSATVIVDGPLGRLEQSTHSMSIQDAALETLNADDCHGKRCAQRLLDFFRRAHQDSLLQFIAAGRDGSVDSSTAPSTPRNRKRSIDTEPSTPSDAPSPKPAVTANMSRLLSDLYDESEHDDMALQVAETGKEVESFAERMVAFVYNDTDGDGSATLAGVITPLKKRISGLFLGLSSRKGDEDAMIHQVDDQKALGKSESGTHVDKPDMPAIVAQIVPSKADPSVIVRAHASRDGAEGEAVPSEVGSELMVDDDTTMAHLEVQDIVDAERAVSASIDEGPEDDAQDVEPEECARIRDDLPAPTTSSSLTTLISSWTENTVEVHFGDPEYSDSAHALDQEASPQEAPIPFHDENKPVDLEPEQSSELPISVNEEDEEDRQQNISTPDLEATTQSDPPSSSPAPATQDETRSALELPAMKDKSNDSEAEAEVAQFAVGTLVDEVESHAEAAPDSKETAQMEHAEDPIVEDSHATIIDEVLSEAVETMRIQRESRSHEPRLDSSEDLPVFEEADAIGDEEEEVIDDEVGEGEYVTHRSPRGIDERSEMRSADLYSVPSSPLARFTSEASDDSLQRDEVSDDGSQRNEASDDGEQREDPFNPPKEATPVVGAPSATSSPGLESPTPQHAPRPKPKPVPASKPTPKSASIPAQSFYVDVPALPRRRHSSMSEHAGSSRSSRQIESRRPLGPTDKSLESPIASIRAKNEARLFDDPPDLDEPGSREASVQSRSSSTRQLLGDSLAQSSPGPIPMDVELMEEHLVEAYQQIEAFGEAGFAADDVAPVPQSEQDNESDDVAEPISPPRRQPRRIIVEEEIPLSSPLPCLPPLPSSIALSGSIRLFDSLSKSPPPVEHDQAPPSPGPSTRRQDGDSSSEGETLIMIPRARPKKKRKKASPAVKKNLPRPSIESAQEVSDGSSADELDMLRTAKVRLSPIIGRKITLQSRHITTPTTTEPYHPKTVTKTRNANPSNHRLSLPSRSVPALDRSNAKGYIIVPSRPHASRDNAPPSNGRPARTRKSTANWWELSKGLQRNEPLKTKRQRKNDDDYEPRGLDEGLEDDEVVRSSVTKRKSPSSLSKRRRVSRVVDDDEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M4P8</accession>
    <name>A0A2X0M4P8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g02083 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C003g02083</name>
        <name evidence="1" type="ORF">BQ5605_C003G02083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY38836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M4P8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY38836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="163" mass="18336" checksum="0E6300718D1C52B2" modified="2018-09-12" version="1">MLTQHSCGDRFQDVCDTQGKWTGRGNVAGSIERSDNRDFLIHDRASRREADLRERGTANLVDVAAVRVLEHNSEYARRGVGPRHRIYEDVGDLDTQFGEMLSSGLLEFGHWYLRQVCPFVVRVAAGRYEAATDRAGKVVFVTRGKVRPEVEHRAINGDGSAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M4S2</accession>
    <name>A0A2X0M4S2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C001g00923 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C001g00923</name>
        <name evidence="10" type="ORF">BQ5605_C001G00923</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY50758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M4S2"/>
    <dbReference type="STRING" id="796604.A0A2X0M4S2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase RNase H-like" evidence="8">
        <location>
            <begin position="69"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase zinc-binding" evidence="9">
        <location>
            <begin position="319"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="230"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY50758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="361" mass="40970" checksum="DAC2B59AA43CACAF" modified="2018-09-12" version="1">MAAPLTNLVGEAPWTWSAAQDLAFEETQRAIDQARQLTIRQEELAPRESEPIHFGHPPTTAVRNPVSGKYIFLQCDASTVGTSACVMYGENWWNAQPVYHHSRKLTGAQLNYPVHEIELLAIYEGFQKYRNILFGRRVIVLTNNNSLTSFLTAKEVNDRQARAYAFMSRFAFSIRHIDGECNHVPDMLSRQYENDNLAEGYVEDGRLDDLDTERDDGPLLFDRSLGAMTASTKAKGKGKAPDRPGAKAKTTRRPSGKRAAKAKAARLKEEATVTTHSSKIVSQIEDFDRYKLIDDVLWQKDEVFGDRMCVASGKVDRRTAREVVLEHVHEMTGHEASRRMTDHAQHHFWWQSLSSDIDKYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M615</accession>
    <name>A0A2X0M615_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g02568 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g02573 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g02573</name>
        <name evidence="1" type="synonym">BQ5605_C003g02568</name>
        <name evidence="1" type="ORF">BQ5605_C003G02568</name>
        <name evidence="2" type="ORF">BQ5605_C003G02573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY41823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY41846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M615"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY41823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY41846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="67" mass="7641" checksum="541BCBADF83730F1" modified="2018-09-12" version="1">MSRVKTEAGSSSTTTLWVLRPNKNGCYFTHFVEGTVPFHVIDGQQSLYKPQERHRGYNAPKISKMQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M6Q2</accession>
    <name>A0A2X0M6Q2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g04356 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">BQ5605_C043g12113 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g04356</name>
        <name evidence="3" type="synonym">BQ5605_C043g12113</name>
        <name evidence="2" type="ORF">BQ5605_C006G04356</name>
        <name evidence="3" type="ORF">BQ5605_C043G12113</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY58263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000117">
        <property type="protein sequence ID" value="SGZ32200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M6Q2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY58263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ32200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="332" mass="37049" checksum="AE67082AD5E299E8" modified="2018-09-12" version="1">MAGSASEKDKENQRRNGKGTARKYIDADGMYARKDKGNMGLRDYTCKRGQIDKIYYNWVRSVVRDALVVAGIRTPTPVQLYGPLAEINQEWSPNHDLPENYNLKDAFRLISAKTSTNTVLWGNLSPLKQREIVKYIRERAGFLAVTSGDWLYEELVIDVLANIRSAWKLAYDREVCRLAGIKGQLSKADIATLRSRHGEGPSRKSQDGVYSASDTGTSDLEEEEVLATRNRTLVPKKRGARQGAGSPQLSQETQQTSPHVGSSGQRSTPAASGVRGPGPPRNKKKKTEHNPNRSQQTNPKRDLGNGRAKEEEDEDQGQDEEEVEELERSPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MB30</accession>
    <name>A0A2X0MB30_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Casein kinase II subunit alpha</fullName>
            <shortName evidence="10">CK II alpha</shortName>
            <ecNumber evidence="10">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C007g04776</name>
        <name evidence="12" type="ORF">BQ5605_C007G04776</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="10"/>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY63128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MB30"/>
    <dbReference type="STRING" id="796604.A0A2X0MB30"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006356">
        <property type="term" value="P:regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14132">
        <property type="entry name" value="STKc_CK2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000059">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000088">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="42"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY63128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="270" mass="31669" checksum="8EFECEC17BBCBDA3" modified="2018-09-12" version="1">MTTAPGTGRSESRVYADVNDKFGRSWWDYDGLMVSWGVQDNYEVVKKVGRGKYSEVFQGVNVINNEQCVIKVLKPVKKKKIKREIKILQNLSGGPNIVTLLDVVRDPQRMQSKTPSIIFEYVNNTDFKVLYPKFTDYDVRYYINELLKALDFCHSRGIMHRDVKPHNVMIDHEKRQLRLIDWGLAEFFFPATAYNVRVASRYFKGPELLVDFQEYDYSLDMWSLGCMFASMIFRKEPFFHGHDNYDQLVKITKVLGTDQLYTYLGKEVRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MBF1</accession>
    <name>A0A2X0MBF1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C010g06012 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C010g06012</name>
        <name evidence="3" type="ORF">BQ5605_C010G06012</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MBF1"/>
    <dbReference type="STRING" id="796604.A0A2X0MBF1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="226"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="310"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="443"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="494"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="512"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="585"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY13967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="617" mass="64464" checksum="0B991E0418BD84C1" modified="2018-09-12" version="1">MSAHSKGGTDKGSGGGGMGWSTPETLSPRSYSPVKPTYPSSSATGSRFNSRAGSPIATTNMAATSAGPNHPLHLPPAPKSAQFPFASTSTATLGSTMTSSTSTSSFRLTKSSDAITAATSSTGLSDGGIGQSTVRIRRAHSPNPSVNSSGVFATTSIDSDVTRPSLRRLTNETSSRVASPSTTAAVGAWSGNGGPGSGTNSTRASLDNLSRPSSSLRNPAAEREVVVHKLVKTDTLASICLKYGISAQALRSSNRLWPSDPIHLRATLNIPLDQCHLPSASAGMERIVREEDGNLVVWERDRPASTSTRTSELPSASASTSTSPWSTFNTIASSRNDIVSPRARRVASNLPEVTDSASSSTADLLNIWNNPEPPHSLLDDLDEDDAKTISLHTQSNDIANGFGKGKGRAIDASPADYLSLTNNPFASPTLQNRLISITPDPPIARSRSSTMSSSPSSVNPFAVASPPTGSNSTAPDGLSKRTLTIERLPSSALSFFPPSANSSSPDRKEYLSSPFSSPQASHSIPSFEPWSNGHRTPALLKRKSSIFGPLVNTLARLTTLESGEEYARRSSASSSPAVAMTGAKSASSSSSSSAGMQKGQRKGWDLTYFGQEEYASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MC09</accession>
    <name>A0A2X0MC09_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C004g02769 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C004g02769</name>
        <name evidence="1" type="ORF">BQ5605_C004G02769</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY67366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MC09"/>
    <dbReference type="STRING" id="796604.A0A2X0MC09"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY67366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="152" mass="15878" checksum="DCEF48099FB651CF" modified="2018-09-12" version="1">MWGGDSLGKQSGATTAEAVFAGINGAEVGIQAATSGLARDLTPEEVAQGFTKAPELFTRTCGAIYIAGENSMPSTVAEQVEIKPSTQDGPNKLPANFDDVEKLQDDKLIGLGLVKSHALQFCYRPVSSEGEPQIGALIDDVFVATGHGPWVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MC10</accession>
    <name>A0A2X0MC10_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C010g06222 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">BQ5605_C022g09589 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">BQ5605_C047g12284 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">BQ5605_C055g12661 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">BQ5605_C064g12794 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C010g06222</name>
        <name evidence="2" type="synonym">BQ5605_C022g09589</name>
        <name evidence="4" type="synonym">BQ5605_C047g12284</name>
        <name evidence="3" type="synonym">BQ5605_C055g12661</name>
        <name evidence="5" type="synonym">BQ5605_C064g12794</name>
        <name evidence="1" type="ORF">BQ5605_C010G06222</name>
        <name evidence="2" type="ORF">BQ5605_C022G09589</name>
        <name evidence="4" type="ORF">BQ5605_C047G12284</name>
        <name evidence="3" type="ORF">BQ5605_C055G12661</name>
        <name evidence="5" type="ORF">BQ5605_C064G12794</name>
    </gene>
    <organism evidence="1 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ23112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000092">
        <property type="protein sequence ID" value="SGZ29282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000113">
        <property type="protein sequence ID" value="SGZ31013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000132">
        <property type="protein sequence ID" value="SGZ35183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MC10"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY14526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ23112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ29282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ31013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGZ35183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="53" mass="6033" checksum="23313F6A842B0BFF" modified="2018-09-12" version="1">MCPPCPNRHSNLSGQLELQLDDTYNVDDPISLTPCLNATRYASRYISIRPIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MC59</accession>
    <name>A0A2X0MC59_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-dehydrosphinganine reductase</fullName>
            <ecNumber evidence="9">1.1.1.102</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C007g04814</name>
        <name evidence="14" type="ORF">BQ5605_C007G04814</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reduction of 3'-oxosphinganine (3-ketodihydrosphingosine/KDS) to sphinganine (dihydrosphingosine/DHS), the second step of de novo sphingolipid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>sphinganine + NADP(+) = 3-oxosphinganine + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22640"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57817"/>
            <dbReference type="ChEBI" id="CHEBI:58299"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.102"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:22642"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.1.1.102" evidence="9"/>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY63640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MC59"/>
    <dbReference type="STRING" id="796604.A0A2X0MC59"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047560">
        <property type="term" value="F:3-dehydrosphinganine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006666">
        <property type="term" value="P:3-keto-sphinganine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08939">
        <property type="entry name" value="KDSR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000468">
        <property type="entry name" value="Short-chain dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045022">
        <property type="entry name" value="KDSR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550:SF3">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGY63640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="414" mass="45115" checksum="A4B1344CC7687A6A" modified="2018-09-12" version="1">MDGAGSVARAGFWPKLDQSRGAPDEDDSSGSVRYVEHDEQSSPARQRRQLTTIGTSSDPLSATAASLTRRLMSSAHTWIPSSIAIPYITAAFALLVTSIVVLMSFLWRRRIDFSGKHCYIGGGSEGLGLALACLLVERGAHVSIVSRSKVKLEAALARIETHRQSPSQHIASYACDLTLADDAAATLNLACEKLGEAPDFVFACAGGTIPGFFADLDAESHWQGMQWNFKTALCTVHEATRRMRQEGKPGKIVFTASVLAMMGFAGYSAYTPSKYAIRGLAETLRNELQMYGISVHLFLPATILSPGFVEEQKVKPAMTRRIEGPDVGLTPEVVAAHMIRGLDRDNFYITYEPVGHMLRNSRGITPRNNVLIDTLWGIAGTIAFPIWRRISPDSEVRAEAKKILGARKMQEGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MC62</accession>
    <name>A0A2X0MC62_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C007g04705 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C007g04705</name>
        <name evidence="2" type="ORF">BQ5605_C007G04705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY62548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MC62"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY62548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="216" mass="21686" checksum="56C3F4F606D62930" modified="2018-09-12" version="1">MIEGVGKTLGVAGCAGRVGVIVAAKAEVFTPIAVGGSLVEKGEGGKRIPGLRTIGTDVAVDLGVASMGIDTDVGKVGRDSTEGEGIARGVEAEVTVLSDELDALFGGLRSWPGEGGGGSCKTLGNDSARVADVGNDGRGFLRGLSQSISSSDSSLAAECFRFDDSVSARGVCKDDDGGTGADDAFTVVCCTGGDSSRGKAELLPSKLSKRRRRAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MCI3</accession>
    <name>A0A2X0MCI3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C004g02637 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C004g02637</name>
        <name evidence="10" type="ORF">BQ5605_C004G02637</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY66180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MCI3"/>
    <dbReference type="STRING" id="796604.A0A2X0MCI3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019321">
        <property type="entry name" value="Nucleoporin_Nup88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037700">
        <property type="entry name" value="NUP88/NUP82"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257">
        <property type="entry name" value="NUCLEOPORIN NUP84-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10168">
        <property type="entry name" value="Nup88"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="65"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="303"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="989"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY66180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1023" mass="111380" checksum="15C1B98F8A37D9FC" modified="2018-09-12" version="1">MPDETCPKVGPCACAITLTSVCCRARRTPLKSREPHRSQQNTFTMPSWLSSLSSHPIFELPDWPATASSTLSGPGPHPHHDRTSNLTPLAQASSSSSRPSLFGNLSTTPKTSRHGPTLTRSSSATSSVNALASTRSKKPQVGGLGRQSKMVVVAGRDLIVAVGTELRITSLTQAKARMQHERPHANEIHHDRGEYKVLHTPLINFEIQQLVLNPTNTFLAVVGAHSIAVVVLPRKGSSSIVGSTVECRSLLVGHYYHGLSGSPLVSQILWHPWGTNSSSLLVLTIDSTVREYDISTDVEEPTQTLSFIEDQPQQTSRSTPSKRSGGPRGFSAEDKNAKKAVAMCLGGGQADWGPLTLFGLMRNGDVVAICPFLPKKASVPASYIHALSSFVSTKVDYLNVTEPTSDSMALTLKNSTPTKSAAAPHLSSLYARQLQYVHQLVRQASRAGASSSNFESEGIDIDPTIQDSLKDHLVHLTAPRFGAGNATPKVQGPFLMQPEPIELDHGEDCELESLATDMMYLYYEPQDRMREGDKEVKIGLGVVGIAYLDGKVDLCLEVEKVEARWEEGFAELRGEGEDALDELPSLCVYETIDLGLVSELDEQQPRASMTLEGGWVSFIKDPLYVDTIYLQHPLGSHCIVLSGWLDDLVDTLNPSLEKGQEDEEKQAHEMNKAVRASEPSQVVWIVKTVNPIAASDDSTTTDATTPLSVPVVGMDLINDVYLGYAMLLVTSSLQLVAIELSLRVDSSLLPSTTLSSSTHRGKGLPNEPPPYLSLLESPFKTPSILASSSQHVLPRQVVPKSLANKGALETVTPDSLRFIGKSVEALRTRLSDLVDASDQVQNRIELQLAELGRQLTKVHELRKIIAGGLIQDTSLNAGDEERVLKDRIGKVKERQEVLLKRTDRILQGLMDRHAPSVSTFERNWFDELKRLEGEIEGGKEGEGDGPGLTTRVERLVEKVELLKPGLEEMKKKTEGPSGAGNVVLGGTQLHKVEEKLAEEAELIMEARRKVEKLSQALGALSMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MD06</accession>
    <name>A0A2X0MD06_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C004g02698 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C004g02698</name>
        <name evidence="6" type="ORF">BQ5605_C004G02698</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the translin family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY66714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MD06"/>
    <dbReference type="STRING" id="796604.A0A2X0MD06"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14820">
        <property type="entry name" value="TRAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.190">
        <property type="entry name" value="Translin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.200">
        <property type="entry name" value="Translin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016069">
        <property type="entry name" value="Translin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016068">
        <property type="entry name" value="Translin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY66714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="322" mass="35624" checksum="E46CC87273E783DE" modified="2018-09-12" version="1">MATLSESVATTSAKTLDTPSLKRTRGQSLLDDFAGFRTELDAHVGLSLPAIRNCTSRRVGLERVIKTSRDITALSKKLIFTLHRITNTPRATVLQEAEAKIAQLRELFIKVHVEVQGDQFWRYVLDKRTCVNEILAESLLLCPHHRYEKAISPGMQEYLEGWTFYYYILHQRIPTLSEAQASLLSPLPAEPSESTTKPNDRTPLVRVTGEDYLGGIADLTGELMRLAIASIGKSLAAATAAAGGDKGEDIDDLGSLVRAIKGDLDPLAPYARWLGKKLVVLDQSLSKIELASYNLKVRGAEFPDAQPRWTESDERDSALEAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MDW4</accession>
    <name>A0A2X0MDW4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C004g02978 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C004g02978</name>
        <name evidence="3" type="ORF">BQ5605_C004G02978</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY69223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MDW4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="2">
        <location>
            <begin position="498"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY69223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="590" mass="65012" checksum="115A248CBF3BC081" modified="2018-09-12" version="1">MYLKSLFLTRLRPSGPPVVDVLYQHTAVSAAPACGVHVPIRSHVQALCAPMTLIQEQTFATMPRSQGRQGGPSQPRQVLGREGSAVPWACSSARCWAPRGSTLLFVPHRSTESAPRRVMTTMQPILALRHVYEPAVQLCRTDSVVSAMANSTLGSPHHHLRKGECAGLESRSNPSSPTFSQGKLLQGSDSDAKAFREDARSYNNALSFTSLAAHCWDQTQVDTLGPPVFRVFGRLYHRLGALILAVNQRPAFAQTSLIDPAEATNTRLQGPDSAETRIQRSTLTKLESMLRTGNCFVREFASAKGRAGWDTAKEWVLRLCLPPGRDRRTHNLPTTLFSRCTVIDVPMVGPSTKSLARSIRPRCLSVTHYFFLQGKMASTPTFLFAGSTKPGRQSPETESRSTMVSNCARYLPVLVWMTKTNRRTKTATMRMKTARKGTKRMVMANVRVFGSFSEAPFFSRSQFFAHYLPNATSTSQSRIATNVLSWSLFDPEPNCDITQRDQDAMACAVKHGKPPLLITMTCVPESPQTKAALGPNDKACTRPDLIAQVFEAKSGNKRHAGCFGDECRMNGFASLLYFVGCFLNLCAEIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MER3</accession>
    <name>A0A2X0MER3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C005g03399 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C005g03399</name>
        <name evidence="2" type="ORF">BQ5605_C005G03399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY75078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MER3"/>
    <dbReference type="STRING" id="796604.A0A2X0MER3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="575"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY75078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="749" mass="83991" checksum="7392FF0673E95EFE" modified="2018-09-12" version="1">MDILPHTPPPLQPSSASPKSTTLRRRRKKVTSSNKDTFENGATTSVGTEEEAKTKKMKRRKLWTKRVRKREPSLSPDSELFDKAFGFNFGIFRSPTKRRPKRQPSPPTSPSVQNSTRRRKEHSEKSIAGLHKSPSEPWTDIADGATAWPLDTETGGFEHNFKPNSAPDFEPDYDFGRDFGGGYSSGPEHSPFHPDGASQDQAPSSLKRSQIERNAKKQRNRRRNARAEAKTRASKRAELLQAYLLMKKKAKEVLRQSGFVPSSDDEGWCDACHERRVTRKVRVVDLFLAGMRELRYCPCYPEIQTLAAHGLLPTSLSSIRKREGRTAFTFRTIEYLDTYWGVDPFGIYDMSEALILFWSSELSSEDPFNKGPTVRQHLQAAMDEYRFMQQLQATLTAEFIGLSPRERLADVCPACFGPRIDEAGKSENDLDVIIAVDGNFQHRRFARATADPLKSRPALFLSPDKIRNEQALIDGSTEAGEQVPWCCWCRDECTANWKAADGGVTSASSNVVADTGLVAAVCRHDHCLRLCNLHQSGEKLVYPVSLLKWILEEVEVGETDCTTGPARTSDATNVGSSSGSGSHQSSRQDRSRVGVAYDIACNLSSHLRRLISPRYAQRNLLADHLPRLEFALSSMHAYAHKWSCQVDFDPRFLPSFGLTDAEGAERLWSQLRGMIPMNRSSSASHRLENINRRASAYNKQHLAELGSPKLTKLNSRLKNAIKLKAEADRVIAEVVNRSAEWTVATLLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MF08</accession>
    <name>A0A2X0MF08_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C005g03499 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C005g03499</name>
        <name evidence="2" type="ORF">BQ5605_C005G03499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY76551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MF08"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY76551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="138" mass="15395" checksum="6D43062117C067DA" modified="2018-09-12" version="1">MNELTIVSAATLRNGFFDSKPLHVALLKPRSRGVPWLCSSVLAQMFRWKIPVIVKVFEQPPLTQTPHPRHHGTLFGCDLSSEDITVPPPVPTSHPSSSSATITVPSPDANHLSETLQLPLRMRTMCEQTFQRTFRLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MF42</accession>
    <name>A0A2X0MF42_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polynucleotide 5'-hydroxyl-kinase GRC3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polynucleotide 5'-hydroxyl-kinase grc3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C005g03529</name>
        <name evidence="10" type="ORF">BQ5605_C005G03529</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Clp1 family. NOL9/GRC3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY76919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MF42"/>
    <dbReference type="STRING" id="796604.A0A2X0MF42"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000448">
        <property type="term" value="P:cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF3">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-HYDROXYL-KINASE NOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Clp1 P-loop" evidence="9">
        <location>
            <begin position="460"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 P-loop" evidence="9">
        <location>
            <begin position="585"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="562"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="19"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY76919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="860" mass="93048" checksum="88C7156ED9BCEFAF" modified="2018-09-12" version="1">MAATVVDPPSKRRRTDSTSDLSSSSTSTPVAAAPMSAVAARRAAAQAQLDAAAAAALEQPKASTSKLETSIHQSSGDDDDDDDDDADLLPQVLSSDDDDTNDDNGQHSSSTKSARSFNGKVVPEKKKKISKARTATKSTRYFAAAASTSRSDDDGPAGDRGLAAKNNSKESTFVPFDPMDESADDATRNSANQARAYRGKRRREKTAFIDPLCASNFAPELNVNVFRVSLTTEHTRADAEQALVFCLRADQMIVVHGVLMVTPIYGALAILNSSLPAPEPSSDTIDFSIAFSNSTHHPIFAPSSHPLPPMSPRPYPSRSHRPSYLLLPTGQTVDLSIFEAAFVVRDHHSGVEGIEPLLKLGGLGCAAGMWDVDHPQGPIKRTSECDGKTWKLVVEPTPSLTLIRSVDGWEATLAALATHLDPASKRISDAEDADDADEDDEELAYAIPTPSPRLCLLVEGPKRVGKSTFSKLVLHQLLSRFMAVAYLDTDLGQPEFMPPGFVSLNVITSPQLGPSFTHLSVPMASYFIGQTSPANDPTSYLDAIHKLYQLFEHEVEYAFAEETRSTRRRGPQAQSSTSKDGTKATDRIPLLINTHGWKKGLGADLLSKLKMNIQPTHIFAFDHDQEDDFPTSMGTKGGPIVHRMKAAPPSPLDSKWSSFDLRILQLVSYFNAVFLTSTSDSSGSTFVASWDCLEPLVRRRPIVLDWTTSLSNVIILDSEIDYDQALYALNGSLVAIVEPSEVNDEDVKTNLSSNFPYDAHTSITSTRAHGLALVRSIDVPSKSLHLLTPIPRPQTDRIALVRGIELDIAVGLLMDPLTTGGVENGVAGVGWKDVPYLSVEGGQSGGRKKVRRNLMRRGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MFT8</accession>
    <name>A0A2X0MFT8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C005g03620 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C005g03620</name>
        <name evidence="1" type="ORF">BQ5605_C005G03620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MFT8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY77382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="89" mass="9577" checksum="967BDD25CC13831A" modified="2018-09-12" version="1">MFVGSQRARSKVLTVSYSVWEGSLHSNAEHIAHCISLGSLHPGQQLASRTTPTSMIGPNIACCSTSPEFELLVFRLLTLLPPTSNAPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MFZ3</accession>
    <name>A0A2X0MFZ3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C008g05262 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C008g05262</name>
        <name evidence="2" type="ORF">BQ5605_C008G05262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MFZ3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY79969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="83" mass="8703" checksum="DCD9BB071878E450" modified="2018-09-12" version="1">MLPLPHAYGPALSHRGPQLVGKFSAPAGPANPQGRRPDIVTGGSFGREGTSALPILPTPCQISSRRSEVGSIVGVDDRCWPCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJZ3</accession>
    <name>A0A2X0MJZ3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C010g06174 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C010g06174</name>
        <name evidence="2" type="ORF">BQ5605_C010G06174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJZ3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016039778" evidence="1">
        <location>
            <begin position="22"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY14407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="161" mass="17668" checksum="2800B081E8C499AA" modified="2018-09-12" version="1">MLLKLTFTLALTLVSLGVSASQSNDTVEGRAMSPSSTKSTVTSPAYGKALKTDEVFSFVYKPAEGDREDGFFQITKLSLKAVEKDQFPIFDFANDLSSAQTEPVSVDFRLPPLEYFNANTVKTAKTGDSIEAILEISEQNFRKQVQTINVPLTITLHAHSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MK78</accession>
    <name>A0A2X0MK78_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01275 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01275</name>
        <name evidence="2" type="ORF">BQ5605_C002G01275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY31909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MK78"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY31909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="297" mass="32029" checksum="1DA8AA826A504FB7" modified="2018-09-12" version="1">MNMNGSASSSTDNLFSLALNSDTASYFGAATAGDAPLLVQQRIERVLGRAPDSRNDEHDGNAPEIEQQFAAMASKIEARRADLRSNEQRAMAFGKTEARVAAEKRGPAAYLELINSHNLGLEETGQSHRFTLAVCRPLFRIRDNVPRAYSSLVYPSGSSSTLLQSSSRASTTRHPAPAAPLPDPAFSRSTSSDARTSRSSPVHADDRNGGRLFTPAARSARGRLSGAQLGLKRSASHAPSPSPAEAMQVMPISKEESRKGKGVQRFASGKQAEEEEDWGKRASVDLPGRRRRQSERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKQ9</accession>
    <name>A0A2X0MKQ9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C033g11175 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C033g11175</name>
        <name evidence="2" type="ORF">BQ5605_C033G11175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000066">
        <property type="protein sequence ID" value="SGZ01944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MKQ9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47481">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47481:SF43">
        <property type="entry name" value="RETROTRANSPOSON COPIA-LIKE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ01944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="344" mass="38545" checksum="1857042E760DF1B0" modified="2018-09-12" version="1">MSLFAATDLPHSKVDKLHNSFVKLKDESNYASWHKKMTLLFMGHKVMDSVLGEQVKPLSVPRPPATDIPDAAELDASADRQKKIATWTDRDIWAQSHIMATLSPEIEGMVMYCETSHEMWDLLEKKYRKRGHNALYSGLVCLLSTKYRDGDSIDEHITKLLTYSAELMKIGKPVPDEYLNVFILFSLPPSWSVVNTWYKQAAAIDEKVTIRPSLVVEHIQSEAQRRATANMQLVPVKVSSSSNAGALSANALKMCDFCNRKGHNADERYTNPNGQGYRPPQGKQSRKRGKARSVKSTQSSNQEAVAFSVMSTGQSAKSRFIIDSGAWKNHTGDHTQLTDFIEDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKZ0</accession>
    <name>A0A2X0MKZ0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C013g07326 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C013g07326</name>
        <name evidence="8" type="ORF">BQ5605_C013G07326</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MKZ0"/>
    <dbReference type="STRING" id="796604.A0A2X0MKZ0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF5">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY15323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="207" mass="23750" checksum="4163B726ECB6DC26" modified="2018-09-12" version="1">MGNSPSKVKITSQDRSILDLKLQRDKLRQFQQRIQVVLLRESEIASLALQQGNKSRALIALRQKKYQQSLLTQTDQQLETLQKLVQSIEFSLVEQQVLFGLQQGNEVLKQLNQEMDLNKVEQLMSDTAEAIAYQEEVSQILSSKITADEEDEVLAELEALQAEQLRQKVNLPHVPTTILPEPTRVHLDPTTEEEPKRQKERRQAMLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLA0</accession>
    <name>A0A2X0MLA0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C023g09653 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C023g09653</name>
        <name evidence="3" type="ORF">BQ5605_C023G09653</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ23881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MLA0"/>
    <dbReference type="STRING" id="796604.A0A2X0MLA0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33604">
        <property type="entry name" value="OSJNBA0004B13.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33604:SF3">
        <property type="entry name" value="OSJNBA0004B13.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="977"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="983"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1056"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1094"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1116"/>
            <end position="1127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ23881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1153" mass="127805" checksum="61C6231CF04EF081" modified="2018-09-12" version="1">MSSLSMQDARRAGTNGVSNGSKVRDVSPSRRRRESSASISISRRLTGKTLSTRRVNYILARVVAALVVVLLLYWIFADRQPLNKSETLKTKWWESDSPADRNRLLPKPAMLPKPPRPKPVPEMSHSLAQITRMSSTFKAISPPDWTAVVHISAAAQYPLLSTLIPSLLRQAVAPNRIIIFAVKGLTPPIKTFGPAVSVQAYPPGRPPVVALLEAVVPTTTTEFILFVDGHLDTIDTNYVARLLHASGTKEYRASLLASGGLVLPTSLDAPPTQCHGAGSTSGRDVDEQLHHQRSKRIHIPTTPFLVQTSWMKAISNGIRTDMEIEAAIPLGLWTKAGIPAYALPVPFVPQLASSTFGCERLKRALQGVGTDRRIGPLFRAEAAGGGGLGFASSQAYGSRAIDDPFVAGKKFARDLGAIVILLSREEELADASVLACGLAQENDVRVYVADLPRGKRSGGRRILFDDADTGAHCHMNVRPLGSGKEGDSVSLAVLDELDNVGRVAVAIYLADGHRGREFEEVLKWNRGILGKGRGGRRRTKKEMEAESATVIISLDKHEMQVADWIAALPLDALRRDGLNPTDWHTPRIDISVVTNNRPASLHRLLSSLQKAHYFGDEVPLYLNLEQTADSVTQRLASDLDWPYGPVTVRHRIVLGGLMPSIVESWYPASNDTYGVFLEDDVEVSPMFYGWLKMAILYYRYSMAMRDRSTRLFGVSLYQQKFFELRPEGRQPFDAHVLFESLALDPTLPYLSQIPCSWGAAYFPEVWREFHLYLALRLSEMAIPIADQIVPEIRSNKWPQSWKKYFIELIYLRGYVMLYPNYANYSSMSTNHVEKGTHIKDAVVSKTRAQYEVPLMTRQESLLALPSGRLPSYETLPIIDLWGMLATDDDIIERGWQSAALLDSCPVPFRLDVHPNYNARELLCAKDYERVERYVNAQPLAGSIKDIQQRREKEAQQILRDREAQANARITAALAKAEAAAQGDMRERPMMAPHPDHGSEYADGPRAAVLRQPGETVEAHREELEELARAANAAEHHQTPHVPEKYTPRQPPLVEQGENDDDADVVDLDSSEQEEALPLDLDADSEGEVISDSFESPRSRAKVQEMEEYQDGADGSDGVDDAGGAEEEVGGRSIPKDRPEALGWEMEGEAADQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLW3</accession>
    <name>A0A2X0MLW3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g01847 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C003g01847</name>
        <name evidence="1" type="ORF">BQ5605_C003G01847</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY37634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MLW3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY37634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="62" mass="6760" checksum="6DCCA136BC720634" modified="2018-09-12" version="1">MDKRRRCNICNDMFGQDTPIGRSGGGRGESVGNYARPHATVAYHAGHGHYCIVSDQAHITNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MM60</accession>
    <name>A0A2X0MM60_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C025g09966 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C025g09966</name>
        <name evidence="6" type="ORF">BQ5605_C025G09966</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIA subunit 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000087">
        <property type="protein sequence ID" value="SGZ26821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MM60"/>
    <dbReference type="STRING" id="796604.A0A2X0MM60"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07976">
        <property type="entry name" value="TFIIA_alpha_beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004855">
        <property type="entry name" value="TFIIA_asu/bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03153">
        <property type="entry name" value="TFIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01371">
        <property type="entry name" value="TFIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47396">
        <property type="entry name" value="Transcription factor IIA (TFIIA), alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="74"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGZ26821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="209" mass="22029" checksum="30F246F1B1B5A34C" modified="2018-09-12" version="1">MRYTLLLSQAAVYRSIIDDVVEKATVDFDEAGVQIEVLHELQRSWEAKVASSRVADFTQDSRMAAIAQAFPMLPSESSTRAAEPPSTSAPGPVASTSAAAAAGVKGEDDSDEKEKDRSTAVAGNGTCSPAVTPAKPKADADDDAINSDLDDSDEDGDDDDDGAGAGQEGDLVIALYEKVQRVKNKWKVTLKDGLVSVNGKDYLFAKCNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPY5</accession>
    <name>A0A2X0MPY5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C046g12274 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C046g12274</name>
        <name evidence="1" type="ORF">BQ5605_C046G12274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000112">
        <property type="protein sequence ID" value="SGZ30925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MPY5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ30925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="125" mass="13541" checksum="2710723B14DAE11A" modified="2018-09-12" version="1">MRCLRGRFPAAWTLRRSRPLIGSAPSVCVNTPLLASMRKSLPNRGQGRCKDLFEALQLAISRLRLWVQDSPSVAVEAKTSWGLNGLHARVVGVKAADDPVTIQEEDSNLAAAVAIGKFITALCVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQ10</accession>
    <name>A0A2X0MQ10_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C025g10005 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C025g10005</name>
        <name evidence="2" type="ORF">BQ5605_C025G10005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000087">
        <property type="protein sequence ID" value="SGZ26944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQ10"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015937136" evidence="1">
        <location>
            <begin position="19"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ26944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="260" mass="28429" checksum="9FD133E1EBD55424" modified="2018-09-12" version="1">MLAVQILSLLAVALPVLASHDGTSFGLDKRSLQREASARIALARARAARKAKRSVESDSDNLATRNFEEAYAAVGLTRRDFEDHMESSVLSKRSQPRFRCFVGRERNAQANANAQCVRHYRNRVTYDPKVAVVKCNQVCTITCPFGYTTRMTDKTTVCVKNVDKCKGKTCPKSPNGVSGCANGKCTLQCTTRGYTLNKAQNACIALGCDPSNCGREGSKCDASYDQKYAATCIVGRCSLNCPRGFKAGTNRRRQKTCVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQ93</accession>
    <name>A0A2X0MQ93_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C001g00282 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C001g00282</name>
        <name evidence="1" type="ORF">BQ5605_C001G00282</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY45413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQ93"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY45413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="52" mass="5515" checksum="A80029A804361FB8" modified="2018-09-12" version="1">MPDSHIQMVLSIARNSIVSGPLAEATDHVTLGPLVRTPDPALDRTSCTLGEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQV3</accession>
    <name>A0A2X0MQV3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C026g10154 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C026g10154</name>
        <name evidence="2" type="ORF">BQ5605_C026G10154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ27645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQV3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ27645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="667" mass="73763" checksum="1E02798F6DF5B27D" modified="2018-09-12" version="1">MTGAVIATSPDARPPSSTSVYAHGAPKQPSRHQQPHLRGSTPQKSRTVLGNITNTSRWQGQNPSATAIKSLVISKPFLQQPHREDVRRDGSNNVTDSILNQPDLRLPASRSMDLPSVAKAILTSKNPSKRSSIGTVQSNDPIWSSIASLERDRIHGQQSKWPSSASNLDQRRTVSDSSHKTIGSLGSSKSSNTTKRRKRMSWLGSVWSGFGGKTFEDEDTEVEVEPEWADELRHKYEGTPKPRLSLDTLLGPMLWQSSNTNAGARLEVPLRADADQASITDDEGSDDVHTREDDTEQGQVLRADVVQLTRLDTPPSLTKKTSVGVVPPRLYETAPTPSPPQCKRRGSATITRDEDEEDQALVFGTFFGSPLKLGSWSAGAQFECDNDDDDETQEDVDDDAESKVERPTLPPLTSTYLPDDPTALPFPTSCTSTYLSSYLSSISHHPRTAPSIPRVESDPPLLQHLRPLTPSHWNHRATPDKNLRTKNSESSLFTWDLKNLPAPHTPREQAMGLRVGWRDLITPSFGLEAKAKSGVKGKKGREKWGAVDGPIERSSSRNTTRSALGRVEEDEEEDRDDVSTMWGQGWTGNRSASRMSYATGYSGRSKASSRWSFLGRHGGSQSWEENGGEGFTKKLKRRSLSLLRLARDTEQPREDERLQNWVAVVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MRA2</accession>
    <name>A0A2X0MRA2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C028g10455 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">BQ5605_C076g12930 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C076g12930</name>
        <name evidence="1" type="synonym">BQ5605_C028g10455</name>
        <name evidence="1" type="ORF">BQ5605_C028G10455</name>
        <name evidence="2" type="ORF">BQ5605_C076G12930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000080">
        <property type="protein sequence ID" value="SGZ11759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000127">
        <property type="protein sequence ID" value="SGZ34632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MRA2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ11759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ34632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="109" mass="12387" checksum="D9213DD580202FA4" modified="2018-09-12" version="1">MKTYYITDSKFDAAKLKDILAGHHLKPQGDFESSRKQLFDHQCTKLCLFRGADVIEAGFQTDSIQFLTEGEVAEVVQKAKDEHDLQRARARALRHMHIQDKPGTTAKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-11-27" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MSG1</accession>
    <name>A0A2X0MSG1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C113g13235 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C113g13235</name>
        <name evidence="1" type="ORF">BQ5605_C113G13235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000107">
        <property type="protein sequence ID" value="SGZ30311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MSG1"/>
    <dbReference type="STRING" id="796604.A0A2X0MSG1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004113">
        <property type="term" value="F:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009187">
        <property type="term" value="P:cyclic nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012386">
        <property type="entry name" value="Cyclic-nucl_3Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28141">
        <property type="entry name" value="2',3'-CYCLIC-NUCLEOTIDE 3'-PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28141:SF1">
        <property type="entry name" value="2',3'-CYCLIC-NUCLEOTIDE 3'-PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07823">
        <property type="entry name" value="CPDase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ30311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="201" mass="22018" checksum="9C2C25DA7407C8C0" modified="2018-09-12" version="1">MSGLSLWLSPPATSPLGDLITSLSDRYQTVYFKPHATLVSDAIVPGLPVDELVKRIGEAIARWKSDRAIQGPGWRSNDVQVGPQILSRTKLASDLFYQCVLATLVPDAHLIALHETLLSSFSVPIPSPSTYFPHLSLVYGDLSPQIKEDIIQGMKERKQVQQEANGECRVAGEKGFKAGEVLLVRTSGSTDQWEILARVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MSP6</accession>
    <name>A0A2X0MSP6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C002g01127 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C002g01127</name>
        <name evidence="6" type="ORF">BQ5605_C002G01127</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY30188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MSP6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07830">
        <property type="entry name" value="STKc_MAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000314">
        <property type="entry name" value="Serine threonine-protein kinase mak"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="301"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="90"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="778"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="888"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1079"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1170"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="150"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="791"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="894"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="910"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="937"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="959"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="977"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1004"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1132"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1170"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1188"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1223"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1257"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1271"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1302"/>
            <end position="1318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY30188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1326" mass="141054" checksum="D68C064BE754374D" modified="2018-09-12" version="1">MAPAALVAGPSCSNNEVVVGPGHHYNGVAGMTGPKYELASRAGAAVAAASPTSAINHASSSWSTLSAGLGDYGAAGSSQAAASTNSLHGLLNRASSSNPNSPSPSRLPSPSSARHSQAYVQSQQQHLLHQLQQHHQQHHQHQHNHHHLHSPSLASIGSASTSVSTSTTAAAGGSGSGPASWFRSSHSAASSFNGAASGLASSPLHQHPSQSPTLPRPNPTSSYASHHAPRPHQPLHVSSSSSGSSWVHDRSTSNSDSLASGLTSPASAHSTSSRGHKFSPPMPNFPPIARQFLPPLEPRSYTIIKEVGDGSFGTVWLADWHSDLQLPPGTLLPGPSSRPEYKGKRLVAIKRMKKAFEGGWAECTKLKELKSLQSIPMHPNIIPLYDAFLLPSSKELYFVFECMEGNLYQLTKSRKGRPLASGLTASIFEQILAGLDHIHQSGFFHRDMKPENLLITTTGLADYPASSLFANATTPPEKDVVVSVKLADFGLARETASQPPYTEYVSTRWYRAPEVLLRSRDYSNPVDMWALGTIMLEVLTLKPIFPGDSEVDQVFKICEVLGDPSTDYGVDEKGRTRGGGLWPRGVKMAKDVGFAFSKIPPRTFTSLFDPNTVSPQMIDCIADLLRYEPRARLTARQCIDHAYFREVAYRYAPYRAPGSAKPAIPATQESMYQAPSLNGLTISTTSAASASIAPNAPSPRVLPPAHGHTPSHYKPPFQVGTEANGRFFPNVDRGDSNSGYRYYPEDSSSIASGMSHYPIHVSSAPLATSDNASSLDRAMMSYPESPSDGQSASLRPLSRSSLWSTDTGDQGWGMTPKEPYRSPASSSQAHMRTNPIGGMGGLLPRRPSFSGVSIAASTFYDGSVFEGITQQRPSSIMSFSVGYGTLDDAPSPTFPDSPSSNITTGSTETNARRHLEHQQQHQQASSRQGPNSGLGFTATPAPAAAPTKSGRWGLGKVFSGDSSADAPAASISHSLKRTPSTASSLNSGTPMEGVTTEASTAPKTKKELKAAEKASRDVERAKRDAAMQASRERARAVMQKKTQLREAADPLHNFSNSPRLVAPVEKGKVRVADTLSVHSSMSQNSFKSKMPQIVEDTSRLQVTSHKARRRHDDDDVHSVSSGEATSIRGRTAQSISGQSISSIASSASDPERRLRQEQLAELGLTRVPSLSSLNSTTSAPARSVYGAGNSTPGHYTRTGTGHSSLESSLVRQMNGLATSSRVSAERSESRGARASSPRDGHSHHERYSPYPFPNGAAGSSTSLSRQHLGQSPPPQSPGAQPMPPNSPYDPSGMVSGAPSIASFHSASVFQSSGLNPTRSSPPPQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MSW4</accession>
    <name>A0A2X0MSW4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C002g01197 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C002g01197</name>
        <name evidence="5" type="ORF">BQ5605_C002G01197</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY30973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MSW4"/>
    <dbReference type="STRING" id="796604.A0A2X0MSW4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005826">
        <property type="term" value="C:actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902716">
        <property type="term" value="C:cell cortex of growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005078">
        <property type="term" value="F:MAP-kinase scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.330">
        <property type="entry name" value="Nucleotidyltransferases domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022018">
        <property type="entry name" value="GIT1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013724">
        <property type="entry name" value="GIT_SHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039892">
        <property type="entry name" value="Spa2/Sph1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056439">
        <property type="entry name" value="VBS_C3G9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21601:SF0">
        <property type="entry name" value="PROTEIN SPA2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21601">
        <property type="entry name" value="SPA2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12205">
        <property type="entry name" value="GIT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08518">
        <property type="entry name" value="GIT_SHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23742">
        <property type="entry name" value="VBS_C3G9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00555">
        <property type="entry name" value="GIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="GIT Spa2 homology (SHD)" evidence="4">
        <location>
            <begin position="63"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="89"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="287"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="664"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="739"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="811"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="366"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="175"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="711"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="739"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="766"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="813"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="855"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY30973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1043" mass="111955" checksum="A91B6E4C82F04109" modified="2018-09-12" version="1">MSGNMPGALPSSASQHSNSSSQSKPAPLSLEQSRQVARTHFDALKGWLQRQGALANAWTRSNAREKLTRLTRQQFQELSTDVYDELVRRSDEGAGQSMSKSGATSKVELTRTTSDWGHFSASHPNLSRSVPCRSQRLSPQAESSTTKTRNSTPPKVQGPRQQRCKPRLTLSPFRQPSQPSSSGGSHLPRSDSVSRSTSAASSSAPLQGTSPIPPPPTNLAQQRRAPTPLGLSQNSSNDVVVPNKSTLVIEESAKLPAPGGSNQLESSTPSLAFGSLTQHASAQVSSIASVPGASPSFSSGARMVPNDYGQDANRQQSPPNKPGHTAQPSEASSMGTRFIGGYGTSSSNDSSNRRNSWDHEAKEKLKADYEYKLTMLQSRIDDLEREVDGARGDLKTRSIEQARLRDLEDQLRGHRERNESQSLDMRNLRSELERLSNEAATRSRGDHDRAASDDLANELRAEVGSLVDELREVNAKYEDVVEGLNRERQAREKVEDDARMWKKKYEQTKTELRNLKATSQLFTATIKVDNDSFMSASPDGLLADVHISEFQTSIDDLLDAARSKEPSSVLTAARAIVAAVEKIDSDVQAIDPRRISALPPSEQGALAQTKDNIGATLSNLMTASKNHAMSFGVSPVSLVDAAASHVSTSVVELVRILKIRRTVGGGSGGRDLPSSSSNVTRGAAGGFEPMPSLSESPDVSNAPPPPVKQNGGTTVGSSWTGGMKSVKNVLGNFSLNRAASTTQQQQQQQAPTPVSSAAPERDSREGGMLPSSSSLGSLNFARTPPPASSHGFGGRAEPNSWDQQIVRAGAPSALSSDYPQHNPQTASPTYGGTSNAPMPNAYGRPSQHDDRFASPQPTAYNGSERVSPNSDFGGGYQDSRDDSTHQQQQHGRGSYDARDSYGDQMGQFRQGHEERNYIENQTEAIVHSIQSLLGAIRGGAQAEQLNENLTQIITIVSSIVAISRDALPLHSRPESEGILRDLAENCDRLSEMQSLAASGGGPNSTAFNKQTKQSMASASFGVAKSLKQLNGLLATRDDEENLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MTM1</accession>
    <name>A0A2X0MTM1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C002g01477 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C002g01477</name>
        <name evidence="6" type="ORF">BQ5605_C002G01477</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY33287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MTM1"/>
    <dbReference type="STRING" id="796604.A0A2X0MTM1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032454">
        <property type="term" value="F:histone H3K9 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045109">
        <property type="entry name" value="LSDs-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12549:SF38">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING HISTONE DEMETHYLASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12549">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="5">
        <location>
            <begin position="667"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="67"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="697"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY33287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="948" mass="105937" checksum="828223DF7F55A5F5" modified="2018-09-12" version="1">MAHLKPFSPESHVTSSLSPLVAATARALMGIGAGARHPGTASPFINSHQADPSRHLSAKFCSLVDYSSSSDDAEGEIDHEMDPTSISATPEWETVHDSQRDQPQFTQDVVPQASAESSKRPSTMATRLVSLKRPRTKAKRDEEAWSPPSRQSRSDSGSDTASDRDSDTSSVIVETCTESPPTNESTGLKDVSNASVPGSPEYLPTETVVGSASIASPQQPRPKRGLPRCRWVTESDRSDEWVLQTGSCITIRRQEAQQCHDCITRYSRCSFAGIRSFPRIEAGSDQLDFDRGTLRPSRLDDEVPHFPTEFDRSFVGEDAIRIKTVASHHLLPTLKEELEHAQKSDCVRIRHELFARQTCDTCLHVIFCGAYKCMCCGRDLCMSCYDQLLKLKDQPIKRLSNADLRHARHLLSVVEGDKDGTGHASAFSEPHPMQQDRLHRCAPRTKSHSSKDFTPYTRRDAQELEQLVVAMQKWKESNALEVNRPPSKDILDALRRPSGDQKLTDSWPHMYLRSEELVDPYVPHQATAVNEKSSDPPPPTPSWFSAAPIPVKTEDPKRISFADLWVLREPIVVDIGNDTFHLGWSPEHFIDTYGEASCNVEGDSTTSTTTVANFFERFGQRNPLGVSRKIKVRRFETALVVCHLGTHALCIGCIEDWPPTTDFKSAFPREYTDFMSLLPMASMTRRDGVLNLAAHAPLNSNPPDLGPKGYFSEESDDRPGGQGSTKLHMDVADAVNVMLWAGPWKDGAAGAAAWDMFRVEDADKIRDFLYEHFAEKYGRPVAQMRLMMNELSFPFLSPSQTPKTDLISQPYRNSPIHSQLVFLDQDLRTQLLESKGVKPFRIWQRPGEAVFIPAGCAHQVCNYADCIKVEMTDEFRELTKECQLWRSDVLQLKTQLLWAWVRRRTGMIVPLRFLEHSIDLHSDCLVLQKSSERILPSSGGIGGEGGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MTP8</accession>
    <name>A0A2X0MTP8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C043g12110 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C043g12110</name>
        <name evidence="2" type="ORF">BQ5605_C043G12110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000117">
        <property type="protein sequence ID" value="SGZ32192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MTP8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ32192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="216" mass="23142" checksum="CCB822FE9B484E8D" modified="2018-09-12" version="1">MVEQGGNNPGGTGDAAGLPNTAPSARDRQKLRAAQVFQDEEGGRASGGRDVSANTKCQWYNIIFKELFQSPLRQRSVLDGEKIQSPKFVYDVKALRDNARIIVQRGALLRKADFRSPSSKLKLLGRPGSDHPIAACRRAELQAGGRAMLTGGLGTRAPTSTASEVTMAELSAPAGLVDAHAGRRSWLLKGQNSLDNTGHHDPSFIVLLHMHPALGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MTY9</accession>
    <name>A0A2X0MTY9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C007g04379 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C007g04379</name>
        <name evidence="5" type="ORF">BQ5605_C007G04379</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY60091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="491"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="257"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="767"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="267"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY60091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1385" mass="153945" checksum="71CC9F552F5939A9" modified="2018-09-12" version="1">MSPSETIAQESGEIKIAKLGKDNYELWSIRVEAYLESKGYASVLEHGHVRPSDVSLAEWRTMHGLDASVTDIQVVVNLQKKDRSARALIIQCIDDANLKMVKSKTLSAKDIWDKLRQHHEGNAKPFKIRTLLMELSNAKYDEDENMGEFLKSMIDKADQLDDLGQKFGDEAMIAYILQALPPSYEMLKQAIRLGENRSVDHVINRLTDEYTERKLSGKFDKLLKNAGALAVQSTQASRDPNCVCRGCKGKGHFAMDPECPKYDAKKNHGRARNRNKKKKQDSKESADSNELAEFVLTVKSLDESHSLQNNVANRVSQLNQGEIWILDTGASQHYVGDASLLSNRQSGNLKVQTASGQVVHCDTYGMVRFKLKSGASLSLANVYHLPGAPVNLISTRALFKSGAKCGWEDGKDVMTITYQGVILAKTLSGTGYALDFTRIVEDQAHVATRATVGAPLMEWHRRYGHVPVSSIMELVKSGAVEGLVLTDEKVHDCEPCISSKSRASKFSELATQVTDVLQRVFMDIGFVAEDQVDFQGRKAYLAIVDQYSTAKWTFPLKTKSAEEVTRRVRTDNGTEFTNKLIGADFQSQGILHETSAPYTPQQNGTVERFNGSLMAIVRAVLAASKLSWKYWSYALAYATFVANRILHAKLEGKTAYEVFYGKKPKVSHFRPFGSTVYAQVPKSKRSKLESTSVKGIFIGYDSEYNYRVLVDPDSDHKVIVTRDISVLEHKSEQVGVPEVTTLPVGPDEEKGPVDNDEIVVDELQDQVDGEQMPPARQNRPRWEYGDPAVKGRNPGRYEEIDANNEIPHRTRSQRRDAEQQVMYGSAMSVSLPPVPSNYEEAMASPEADKWIAAIKAELDAMARHQVLIDSDLPSGARALGSKWVFTRKENAQGEVTRYKARLVAQGFAQRPGIDYNETFAPVARPSTMLSLVGTAAAQGLFLEQFDFDSAFLNGTMTEMVYMKYPKGWDRPQTGQALRLVKSMYGTKQAPREWNAAVNSLMVERGYKRSDADSCLYVKRVDEKFIYITLYVDDGMVASNDQEFLDSEIEAFNKVYKLKRLGPVKLFLGLEFERTSDYIFVHQSKYIRDLVAMYGGGSVSKHPVKVPMEPRSDVEHSTDPFDDVALYQSAVGALQYAAHRARPDIVTSVRAAASKVSAPTQADWIAVKRIIRYLQGTVDWGLKFNHGGSTVFELYSDASWGDDMSTGKSIGAFVSILAGAAISWQSKQQSMVATSTTEAEILAASAAAKEAMWLRRLAADLELEQPKATLIWEDNQAVIAIALNPAHHGRTKHYNVHHFYIRERVTAGDIRIKYCKTGAMTADILTKPLARNLFELHREGMGMVGAGARVLCGGPAEAAGCLHEIASFWPSCFSLFSTTHSISHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MU42</accession>
    <name>A0A2X0MU42_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C074g12911</name>
        <name evidence="14" type="ORF">BQ5605_C074G12911</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="FQNC01000129">
        <property type="protein sequence ID" value="SGZ34968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MU42"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08284">
        <property type="entry name" value="RVP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="12">
        <location>
            <begin position="554"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="13">
        <location>
            <begin position="1088"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="204"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGZ34968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1243" mass="139877" checksum="77988BC5F2DD821F" modified="2018-09-12" version="1">MEGDRTFGLVLVNYYCLILSIVLEHRCTRCFHFFFDNDQDTMSEPHEDAPPRWKLHAPYRDFDSSDVDKIDIIGQLLLDPELKVWYSSDAASHVNKKYGTGDYREFSTAARDLQLELGVSLVSDTQLVRMLLLHMDEELSQRLQLSEVIKGTGLSPDELDASIVKADSTTSSAVFDYQTFDAEARRLWQVISATRASVKATAQASARTVRSTPTLRTTASPSTLPPLSSKTRAPPMTDRERAFLRSNQGCFKCCKINAGHFKDTCTTWATSACKVPAGWRQGPVSPEQVASLSNAVDEIDDKGEELHCLCDDEYDNGTDDERCEPISLSVKLTTEDGPALRALVDTGASASFIADREVEKLRLTRRKLQVPTSVSVAIQSHRVSHPVTEFVCVPLRTLNGRWSTQHVVLKIAPLTSLKVVLGRPFLKRHDILVDCKRRRVLAPDPTLPGKHINLMHRGEKGEWSESAVQASIRACLAHLEEQQAEESQLRALEVAFRKEFSDRFPADIPPVSQYESKVRHRIALKPGMKTPRQPTYGTPMRWRAVWRCLLDEHLAAGRLRPSSSEYSLPAFIIPKKGMDTDPSIMPRWVNDYRILNAATVPDRTPLPLPDEILAVAARARFWSKIDMTNSFFQTKMAEEDIPKTAVATPWGLFEWVVMPMGLSNAPATHQRRVNKALSSLIGKSCFAYLDDITIFSDTMEDHQTHVKEVLEALRRADLYCSPKKTELFRTSCDFLGHVISRNRIVADQSKVERIVGWPRPRTVTELRGFLGLVQYLRKFINGLAQHTKPLADLTSKNANVRLMWGAEQERHFNAIKAIVTLLPCLKPIDHTDSADPLWVMTDASNVGIGAVLLQGQDWRKAHPVAYWSRQYISAEVNYPTHEQELLAVVDALRQWRVNLMGVHFHVLSDHESLKYLKTQENLSKRQARWVERLADYDFDITYIPGGENTVADAMSRYSFPQGEPDSVQAVSEMDVDTQLRGRLVEGYDSDPFCQQVKRNLDSSPGLLPGFSCVDGVLYLRDGCTCGATASGDAHDALGHFSPHKTFHQVSRTFFWPRLRTSCDAYVSTCDVCQRTKATTTGALGVSHALAVPDGLMQEVALDFVGPLPKSQGFDMLLTITDRLSGYTRLIPSLAADTAEDIAERFHEGWHRFFGPPTRIVSDRDKLFTSHFWRAYHNLMGTRLAMSTLFHPETDGRSERTNKTAIQALRAVVNKQQNNWVRHLVNIEFVINARVNASNEQIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MV13</accession>
    <name>A0A2X0MV13_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C143g13441 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C143g13441</name>
        <name evidence="2" type="ORF">BQ5605_C143G13441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000140">
        <property type="protein sequence ID" value="SGZ35647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MV13"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ35647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="235" mass="24976" checksum="6B425BCDC40E14B2" modified="2018-09-12" version="1">MSTGDPGSPTAGTATSKTQATGPATATPNYAAAASQVTQSPEQQQQQQQRAKALGSLLQAMGLYPETAWIVGSRPSTSPKLYPVATATSLKSLALNANRSVENIFDYALEVTLSHQSASRASHADKTDLVACVTRLLLPISPICFEPGVPLPDHLAAYRPQILGVQHSSILRNGRLTIALRLVQDLSGKGHSCQLVQVLRIISVDNASAFAHVAGDYSAFLHFDDDSLFKRPNTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MVF1</accession>
    <name>A0A2X0MVF1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C004g02612 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C004g02612</name>
        <name evidence="2" type="ORF">BQ5605_C004G02612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY66015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MVF1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY66015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="564" mass="62711" checksum="0E9BD8E7048CB37B" modified="2018-09-12" version="1">MASATVDSHLANPLANLLQHSLNRFLSLVKTTLWIAENKSSLSEVSRKRVLNTTQPSNNDNHTEHLSTDPTCLKLQNELQVYVRQEAIKDHLHLMKLDDSKDDPEVNINTAALREVKIEAAHGAMAKIEQRSNGAVTLFVFSSPWTKDRLAPKFNLVTSDQFNRELKLWCTIIENTTGQQTGKAQPTVSRKAESLESIGLLTRINWPAWAPAMRLALQSISAFRVATGEQKKPPASQPPNQSLKDYTSLCNDYDAKDAKGRTLIRSHVDENTWFKLKGSAVGASLHQVWTGLVRAYETNSVPFVGTKTLRAYWNLRYEPGTSVTSFMTEVERLGELCNRQKMSFWKQQLGIGTEELQGFYAQIVDILGEERGKALLSMVLHVDDFAIKTVLMEQLPEKYTFAFREEKDVDLFLEKVRTAYDEDVIMNGANDKEQTEAPASAFAAARQEADPGQAPPCNGNCACGQQPHAFATAGQPRGHAGPTRNSYRSGGHGRTGTRVGAKTRAEHYANSDKWGKIVDGKFITLTSKKKVCGRLWWTYQHTVVSAAPACGVGVTIRSHVQALW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MVW2</accession>
    <name>A0A2X0MVW2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C003g02329 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C003g02329</name>
        <name evidence="6" type="ORF">BQ5605_C003G02329</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Necessary for protein synthesis in mitochondria. Functions as a ribosome recycling factor in mitochondria.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRF family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY40147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MVW2"/>
    <dbReference type="STRING" id="796604.A0A2X0MVW2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.40:FF:000001">
        <property type="entry name" value="Ribosome-recycling factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="entry name" value="Ribosome-recycling factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982:SF3">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME RECYCLING FACTOR PSEUDO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="RIBOSOME RECYCLING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="Ribosome recycling factor, RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome recycling factor" evidence="5">
        <location>
            <begin position="131"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY40147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="289" mass="31152" checksum="75288DE0E2A28C79" modified="2018-09-12" version="1">MSWRIARIASGLGSTLAARTRTRASAACTCLNLPSRQPIFTPHGQGVVLGSIRSYAKGKSKKATSKVSEPAEDVTSSDADTKRGKGKAKFVQAQQLTNDENLGVCDLKTLEASMDEAVDKLRVSLKAVVGRVGRVSPELLNDIKVEESGKRRPLAEFGTVSVKGGRDLVVHLFDESFMKAVSAALYASPLSLTPQSHSASSLLVPIPAPTWEKRKAMTRQASDACEAARIAVRNLRTRGQKEIKQDLSTSVVSKEEARSDGKNLDAATKKRTDEIDGIFAEAKKVLMDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N1J5</accession>
    <name>A0A2X0N1J5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C038g11668 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C038g11668</name>
        <name evidence="2" type="ORF">BQ5605_C038G11668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000061">
        <property type="protein sequence ID" value="SGY91450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N1J5"/>
    <dbReference type="STRING" id="796604.A0A2X0N1J5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="195"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY91450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1013" mass="113909" checksum="E8B8CD7A645C0C7B" modified="2018-09-12" version="1">MARRLHWERTERMEYLVGRVQDLEAIPEWGEAETAEWTRTSEELKRAVEERARLLRIRAHVPEIASKERLSRPVHAKLAARNSDSKITALRLSNGELTHDIDVALDHTQAHFQRLYHIEPRDPDRVNRLRDEFLAPIRAARTCDDPRSDPLFLRRLSESQIDLLQRPITKDEVVATIGTTHPGQSPGPSGVPYELYQTAPKAWAKQGQGLVRLIFKRHKKNADRAEFSLYRPITLRECDYKIFTKVYVARLNQILPDLLPPQQHGFVKDRRLADAALHLCLLIEEVGARRTEFPAAALLSLDQSSAYDLVEHDWIFAIFDALGAPATFLCVLRMLYWGDSTTARYIINGFLTPPVQLTCGLGQGDPASSSVWDIVFQPFLDALHRRNIALNLSIPALHPYPQSRAITSLAFADDVVVAVAGLGSLNLLDDVALDWRHATNGQLNTDKTVVLPIGRRWDPGQRPLVVKAAGESLEWIGLPFDPSGDTELAYANLIKRLEATLEGVQHRWLTHHTRAFYVNWYAIPKILHFLAANIPPPEVVKKLDDMLVDFVRGGKGRTSYGRDIVFTAKLKGGLGVIRMQDVVDAVAARIWDVLLGGSGAIWQGLVRAALQRAQSDLDLATDLWPHPSTPIPSDLHPRWRAALGVPKQQDAQVNPRTLTTANLLALPTLLGSLHTPIRGRQTIDAVHISDYLRLQGYPKVADLYRRELYAGGGFHLWTPLADVLGDNSEYDRRGLPQRLAIAAWYRFTVDQHKNTPLAVAVAAGRLNVPPRIGTSAPLEAILPKPVARFAMEQRLPDPVLPQQASQYKLLNMARPYTIRCIRRVLNAKAFTNTLGLKGPPQPDDLRSFWKAVNSKALTAREREVWFKLILRFTPTCKLQHQQQHDTSPACLVCEAPVDDTDHYFFGCVDLRNVWIAARGVLCDALGCDTIEDAQYTTLQWLFGLPKLKAKLSKQEGAGWTIEIFTGMVLEMISSGRWRMQKHGTRMESVERRRVVLEERMKLRAGGARGGRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N230</accession>
    <name>A0A2X0N230_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C036g11497 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C036g11497</name>
        <name evidence="3" type="ORF">BQ5605_C036G11497</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000063">
        <property type="protein sequence ID" value="SGY95474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N230"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="148"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY95474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="237" mass="26859" checksum="CAC75D448E027F2E" modified="2018-09-12" version="1">MTVKQREQHVALDAHADCFVDCPSRCSSPHRSGTRLKDQRRRVMLEKCICKWAGSPRAVAESLVSCLGEGHVSRDHHQQLHRVPAYRQEISLIVTGFVRRRSSKAETQGQNTAQSIEWSRANDMVTEMDDDGDDKQDDEDSTFIETSYTVGLNPTDSSVISTCDCPDFVGHMFPCKHMWLAAPIPNSTAEHEDRIQLYRRLAEEAGRVHAKLLRTLGRYEEYGETGASRGFEDEFVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N2W3</accession>
    <name>A0A2X0N2W3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C033g11129 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C033g11129</name>
        <name evidence="1" type="ORF">BQ5605_C033G11129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000066">
        <property type="protein sequence ID" value="SGZ01150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N2W3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ01150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="117" mass="13948" checksum="3C0F57B2ACB9347B" modified="2018-09-12" version="1">MYLDDPDIELLDDDFERMAPLLDVRLSWSTDEPLEFDTLPRPLRAWRDKFKDREAITAARKQGYRSIAIAGHRLPFGVERIWRHIDYAERMRSVVINSQEWMKSYLGVDIENQPLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N3Z9</accession>
    <name>A0A2X0N3Z9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C005g03176 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C005g03176</name>
        <name evidence="6" type="ORF">BQ5605_C005G03176</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY72481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N3Z9"/>
    <dbReference type="STRING" id="796604.A0A2X0N3Z9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY72481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="166" mass="18614" checksum="3A0A07F5E8D7C569" modified="2018-09-12" version="1">MVFYSVSYLRPESKTPALPSHNTRHIKQTGIITGPPDSAYKGGKFKIDITFPIEYPFKSPNIRFATRIYHPNVTDDGALCVGVLKAEAWKPSTKIDQVLRALVQLLQEPNADDALVATIAEVSRSLLLGERKAHTNALATFFCSQQYTKDRLAFNKTAQEWVKKYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N7V5</accession>
    <name>A0A2X0N7V5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C024g09807 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C024g09807</name>
        <name evidence="4" type="ORF">BQ5605_C024G09807</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ25955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N7V5"/>
    <dbReference type="STRING" id="796604.A0A2X0N7V5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06466">
        <property type="entry name" value="p23_CS_SGT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007699">
        <property type="entry name" value="SGS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044563">
        <property type="entry name" value="Sgt1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45862">
        <property type="entry name" value="PROTEIN SGT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05002">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51048">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="2"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="SGS" evidence="2">
        <location>
            <begin position="114"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ25955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="216" mass="24174" checksum="95A2ADB52883049C" modified="2018-09-12" version="1">MTSKIRHEWYQTPTEIVLSVFIRNVNSEQLKVDLQPRSVSLSIPLATGSDVVFDLDPLAHEIDTQAFSVRVLPAKIELKLIKKERDIKWDAIEGDDEQATTTMGAPVESTPTHSYPSSSKKKITNWDAFVKTAEEEESAQANQGGAKRDPNAGGDKALNEMFQKLYEGATDDQRRAMIKSYQESNGTALSTDWSDVSKRTVETKPPDSMIAKKWEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NG32</accession>
    <name>A0A2X0NG32_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C027g10392 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C027g10392</name>
        <name evidence="2" type="ORF">BQ5605_C027G10392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NG32"/>
    <dbReference type="STRING" id="796604.A0A2X0NG32"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016114612" evidence="1">
        <location>
            <begin position="28"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ28629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="553" mass="57610" checksum="5AF10D47E6E593F6" modified="2018-09-12" version="1">MWTPVRSVNTAAAAVLLLLSFTVAVEAAAIMPQRMAVVPRATARATNCRGTGQYPLPQKNVCKPCSWKFPGASVCSATAALRCATGYLSNGLCVTRCPASTFIGNGACSPCSSKFPGAATCDANAATKCTIGYLSGGKCSSVCPAGFVNAPSTRTCVTCNRFDNLAATCTAGKIATCKSGAYVSRNPSGTLGDQLAPREDLHERYLSLQLNSKQNSCVPCNSVNDFASTCSSATVVTACIAPYMVLSDKRSCVLGSTWSYYLAASIPDVPYQSNVQTPTICGRNAVGEGSQVAVFDTSSLTCFATSTSGASLLPNLIWDADSTVLVYGTCKTNNLIARAARARCRDVTLTPTSCTLANRASCSSLSTPCLGSQFRNFNGVCQECDTAYSESRTCDLFDGATSCIDGTFLVNGTCSSCAVFDPNASECSSNGNLGGCNAGWVLSNNTCVVDTTSSGQNAETVWSFYFNSTIQGLPVVSRNASDQFACADDVLVANYTLGAYDASGKICWANNAARTLTGSETDSVGASIYLITPCATTNRTVESNCYEIVTDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NH16</accession>
    <name>A0A2X0NH16_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C113g13232 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C113g13232</name>
        <name evidence="2" type="ORF">BQ5605_C113G13232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000107">
        <property type="protein sequence ID" value="SGZ30297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NH16"/>
    <dbReference type="STRING" id="796604.A0A2X0NH16"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ30297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="336" mass="36507" checksum="F08384E9C41A33C2" modified="2018-09-12" version="1">MSDQAPPDPGRGPPEPAATGQPRGDAGAEADAAEGPGNPGLALYQEKRDEEKKRKEDVARILKMISVEDGTRQGTRILVLKEALGFGKDRATSLRFSALNATKPIADTSGAVLEVTFEHTGVATEREKSELYSKVLRTLSPDTSLCFNLPAGVVLPPELQKYAPVIHGVAPESIIQNGNTRFKFVVRCASAAALDQVHDAATKIEWKRSFAQVRKRLAFVKNVVELRFIISPEAEYTSDDLWSKLQGVVAKLTGDGHKCDLLQLQQPLTVVQGSYLVARGNYAAIVQFDDDDLFKNNGAQLRQVLPTRIDLRGRLATLTPFATTTRPKPPAADAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NNM3</accession>
    <name>A0A2X0NNM3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C013g07203 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C013g07203</name>
        <name evidence="2" type="ORF">BQ5605_C013G07203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NNM3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY15004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="118" mass="12977" checksum="240082C9F0D35151" modified="2018-09-12" version="1">MSCWCHIAPVTARRSHRLLKDGRAHGAEHNNLRVMLCEKECRPPIHRDIVAARNMPTVGLQVAAFQQHPFRYPKAGKDEDKQDGKGQQGSKAKGSKPGGKGRNKEREGEAREGGVGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NR05</accession>
    <name>A0A2X0NR05_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C015g07981 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C015g07981</name>
        <name evidence="5" type="ORF">BQ5605_C015G07981</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY18112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NR05"/>
    <dbReference type="STRING" id="796604.A0A2X0NR05"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="587"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="927"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="943"/>
            <end position="958"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY18112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="973" mass="109077" checksum="0F7EEAE6FD9DCAAF" modified="2018-09-12" version="1">MLAAGIIREVDRNDVTWWANSRVVPKKDLTAVSKSKAELKETLEEAVARSLSDKGGWAEQKLHEFPHDKAKAPKFRLVHAYLQVNDATANTAFPIGDLDAMTERLAGKSFITCLDMHSGYFAIGMDEEDVLKTTFRVEGRGYFAYNVMPFGLKGAPAKCTFAQSSAVWCGSHLSAKGREPDKAKVHAVIDWPKPNTPWEVSSFLNFAGYYRKLIKGFAAISEPLSELTRGVRVEQSARRQGGSTARGAYKRAMKTRPMDWKWGPEQEEAFSAIKRALSTFPILRSPDWNPPFIVETDASKKGMGPTLSQRFTPTSAAEKAYPAFLLELACLKWATDKYEKYLFGNQVEIVTDCIALAGILSNEKVNHNHVRWRESILALDIVKFTHQPGKQHNACDELSRVVEHLESSESISPESKLPIDWDEYIQSTGPRQVLLLAEATAPAEQGNDLATPLFPTQPDDGLADQVMFLEQATALTALDARYKEEPLFQPLVTFLTTCQFPTGASHSEKGRLRQLARRYAIRAPDVLLFKQGVKTRECIPLHERQQLIEDTHTALNHAGRDLMVVHLSERFYWPGMAQSVAPLWPITVLAPMDLLAMDYFSLPASPNKYKSVPVVTDLFSRYVWAFKFKGEGTAKRTIEGLVEIIKTFGTPRILMSDGGTHFKNAKFEAFCADKGILRITTPPYAPHTNGAVEGANKRILQAISRATVGSVDATTFSPWCQSLEAVVYAMNNRIIPATGYRPADLMFTFARSMPSEGAPPEEQAIEILAHALTSWADLTLREACMVADAEGRVSTAYQTMLDAQARRKEAKDRQLQRWTKAIPKDERDRPFRRGDLVLVHASWLEASRIGGKLQAHWLGPYRVVAPATRTDDADNPSDEHVTFWLELLEDKSPVAGRFHVNRLKLFHPPHDFPIPTTEPMTLDEFHAAQRPKRQPPRTQNEDLPGDVLDDDTDTEDEDGNRNRHDTANVQRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NR59</accession>
    <name>A0A2X0NR59_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C015g08031 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C015g08031</name>
        <name evidence="2" type="ORF">BQ5605_C015G08031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY18293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NR59"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026960">
        <property type="entry name" value="RVT-Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13966">
        <property type="entry name" value="zf-RVT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase zinc-binding" evidence="1">
        <location>
            <begin position="350"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY18293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="510" mass="58572" checksum="42B08A127FCEEE9F" modified="2018-09-12" version="1">MMLEGNRRELKYFENLTQVDQGQDPRRWRPDTFAEWVFYANAHIISTVLHVLSFDIPPQWFIKAAETALTDFVWGGAGRNTVARDFVFQAREDGGLGLISIGDIVHSVALRFWDAVAGSNEAIWAPLARESMRSLVAATRDFSPWGFFSSTARVEKLYRDSTRWGAVVAAARVTVPTIKSELLTLPELLSLPPRLPSLYAEGAKHAYDDADAVAKFAQIADLYWRDEGKGWALVGHRRGFWQHSKEPALQHEHVWSRVGQLLKAKALLPKTALRPARIPLKEAPRPRCFNFFGLTRPFTIRKLRRLVNVVRFPGREDRVKRFRDGTPQSDRKRFWRWLHDRFASAVEQDTHWRLMYDVTPTRKRQHTQGHASSPTCLFCGNDAAVIETVSHYFFECAYSTSFWGGVLRILFDKLGIEDTDVDPSTFTPEQLTMGLPLLRGRGRTTSRWMWVRLACAIGFQRLHLLRWRVHQRFELDKVVAPPSLPSALRAFERDFLSRAGFVPGARDWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NRF1</accession>
    <name>A0A2X0NRF1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C011g06298 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C011g06298</name>
        <name evidence="2" type="ORF">BQ5605_C011G06298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY11860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NRF1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="788"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="788"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY11860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="837" mass="94167" checksum="A28BC3D5D494AF3F" modified="2018-09-12" version="1">MVVGLACLDRSGLVDGFDGSTTAGPDERRPYRRGTNELDVVKKKGERHKIALEPHWRPKLTGAIRRAPYSTLPRNDPTRLETAAGIIRLKLQHQGKIKMDVIEVMKIMCGAYVDVRDIVHPQEAELFDSYTDKNGIEFTGIQARAQRKASKVKTPVTNFPEYLRALKEIQAVENEVFGTWAGADWSHYLKFLDDMHAGVHSGMKGSKLPIAFDGHFRTLRSEPSATPIVNPTRARGADVSQAPPAKRFWPGKEEIDALEDRLDLHALEHICWDCETEGHRSGDHICSNLEAGIGGRLAQMAAKSSAYQVPLSPHTLPPLLAGIGLAPRIQRQFHFEAPTSDPPSTPLLTSSATFTPAQLHSIQRAQCMYPSQFNFVRTIKDNLFETLLCSHLDQDLIRSFVLGFFEAREQSRAFHFFFETDNSAVRLRHHPTLKPDLRNRPGNAWCRPAQPLRRKKTNQNSSQLEPEPRTTRTRTRTPPGPCPRPAPLRPAPQHCKARAPGPYEKGARPWTLLVSPQRLTRVSRRTLPRAPATPLRNEQTNKNERTTTTMARAKKATAQPLPALQPDEPGSSDDEEETVMMPKGLKLNAPKLASDTTLTLASVRAYLNDMDNLFTQYKVISMRFKVMFITHHIEQEWLKDWCGSATEDRTWDEFKVAFLRKALPLDFAYATEKAIRHSKQCLMDYTSWASGLRASQLQLGQAAFSDTSFIKVLLFNMDPQLSVILRQDDLLLKTGMHTDNLDYVVASKTALPKPKTILYEAFERLARLKWNMITALRGVAAPRTHNSTMATRTSSYRPPATTSTGGRRLPAKLTDAMQDYLSLKEGCFSCQQIHTDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NT28</accession>
    <name>A0A2X0NT28_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C011g06479 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C011g06479</name>
        <name evidence="2" type="ORF">BQ5605_C011G06479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NT28"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY12357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="142" mass="16478" checksum="237026E40D7E9CD6" modified="2018-09-12" version="1">MSLKRGNLIFSGLGLFCLPLDILFLSRASQNVLIALRSARMRVRIAGISVTNMFLLRFRAQFEFEIVELLRTAHLLFVCDHIFSLFICGFIEVSLEIVFVAVFVRLRRILDSYHRRYRHRPPWGSRDRLLPAKDVPEGQNGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NUG1</accession>
    <name>A0A2X0NUG1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">galacturonan 1,4-alpha-galacturonidase</fullName>
            <ecNumber evidence="13">3.2.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">BQ5605_C010g06086</name>
        <name evidence="17" type="ORF">BQ5605_C010G06086</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl](n) + H2O = alpha-D-galacturonate + [(1-&gt;4)-alpha-D-galacturonosyl](n-1)</text>
            <dbReference type="Rhea" id="RHEA:14117"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14572"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58658"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.2.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.67" evidence="13"/>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NUG1"/>
    <dbReference type="STRING" id="796604.A0A2X0NUG1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047911">
        <property type="term" value="F:galacturan 1,4-alpha-galacturonidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF12">
        <property type="entry name" value="EXO-POLYGALACTURONASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015975109" description="galacturonan 1,4-alpha-galacturonidase" evidence="16">
        <location>
            <begin position="22"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="SGY14169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="289" mass="30746" checksum="94EF4813B603C019" modified="2018-09-12" version="1">MKGFFSTLLLGASLLAATVQAAPAPIDKRAVAALPPRTGRCRNIKINAVSASKYFIYNTDGIDVYRSSSVKLVNWNVNNGDDCVSLKPNSTEIEIGNMVCNGSHDISVGSLGQYRGQTDIVQNVNIYNISMSNAQAGARIKVSCLGPRAVWPNSPFADPASGGGLGFVKNITFKNFVNNNVDAPLIITSCYNYKQPFCEANPSLMTISDVTYINVTGTASGKQNNVVGVLDCSNPCTSISATGTNLTLPLPKFAGVTPVYNCTHIRDETPVSVTQPQVAVLRTSTLTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NYB0</accession>
    <name>A0A2X0NYB0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g02196 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g02196</name>
        <name evidence="2" type="ORF">BQ5605_C003G02196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0NYB0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025224">
        <property type="entry name" value="CCAR1/CCAR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14304">
        <property type="entry name" value="CELL DIVISION CYCLE AND APOPTOSIS REGULATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14304:SF11">
        <property type="entry name" value="SAP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="860"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1042"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1469"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="674"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="711"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="767"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="866"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="914"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="929"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="954"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1091"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1139"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1215"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1243"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1529"/>
            <end position="1540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY39301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1540" mass="155202" checksum="B0672A4E97BD9292" modified="2018-09-12" version="1">MSSSRVEYPRDDHGTPAASQSHVGAVRTTTTAARRPRATAAAAAAAAGSTSNSATLIAAPSPITTRSGRALGSVGGKSGPGYSPYAYPARRTTATHHDDHDDDASFNASFDSPIQRRRHPPPPPSSSSTSVAPTQAQGQTQKRGGLFSGIKSIPGRALGYIFHRSNSTATLSSSASLQDVRRAVEKEQRSSQSPKNTIASRTRSGAQRSVAPGAAAGGAGGGGGGMSRSKTSVHLSELGRPWPSSSSLSALSTLASASTSVPVASSSTCASNGLPRSSHSTLTMPPSNLNGGAPSFLAPTSYSRQGSPAPSSNAGAGYSRRSPSPTRNQLAGTMSAFNFNSHDAASDMRAGSRAGSSSAVVKAPTSNTFGLQSRSPFVVPRRAPSIARSASVSSIAGASTNGAGVSAAGHSLFPYASPKPRGASPGALSTSRSVSSSLNHKKSYVALSGALNSPRARVGSPLNPHLPTASVGGSASVYGGASVDPGFERARKKQMVWDPEKGLVSREAMEREREATQAPPPKNEAERILEVLEGMGRTPLGEAQRAIFKVSHANSPLAFAQFALTLLSSVQPINVPVPQASTSSLLSRSASTPLLATASPYGRRAPVTTATRESTRGVGLEAQLRAREERRRAQIEREREEREQERLEDEERERQRVERRRRRRDEEERLKREEEDEMLMESIEDEETAPVARRKTRSMAAKEPKPMTSTPAKPRAGTGKGKTAAASTTPARVTRRSARKAASEESMQADDVPMSPPPAALRRRAVKSPSPVKEASPSPPPPEPTPVESAPALSYKPITEAERAANASSSLRPGRSHTSRTHTASSKIFSAREEDLPPVDENELGKIKLPEMKFPANFSFGPIGGAASSTASTSTTKATPAPAPVSAPATSTNSLFGRLAPTSSEPASSKPNAAPTPFPFAPPPAPKNDNTTAPPSPKTSMASDFFSKPPTLPTFSSDTSMTSSTKPPDFFATVSAAPSTKRNEVDAPPLPTLPSASDFFGVNKPAEAKQAPAPAPSTSNVANPFAALGKPVAVIIGESSAENAKAAPPMFGSASSTASPFGASSGVFGAAPKQDGEKDTPSAKPVVSFGAPASSATSSTSAPTAPAPLPSFSFGTPAPAAATASSSTSDKKAEDTPQAAPAPFTFGAPAASSAAAPASTASAPSFSFGQPPAAAEKKPESGSTEKPVASTAPTPSAGFEAAPLMPPVVVMPSIDDGDEDSGMEDETGATDSNTAAKPSPFRFGQPAAGASSPSPFGSSPVFGASAPTSAAPFSFGAPAATTSQKPTSISFGSAANTTGSSSLFGGVGAATSTPFGGFSPSPSPGPPSAGLVNTAFSFGTTSSAAPSAPTASAAPAAFTFGAPSGSTISSGGLFGNSGTSTTNGNMFGSAGGAAMSQTLSAPGFGAPTAPAVRAPFGAPSAIPSFTFGASSNPGTPTTSSTFTFSAPPSSTPMNSNGGFAGFGVAPTTPSNGFGSGLSNPAGGGGTSFGAPSAPVGVSSNAPLSPAGGAGAGAGALFSIGSGGDESPNKRKIAPLRRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NYM5</accession>
    <name>A0A2X0NYM5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C017g08562 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C017g08562</name>
        <name evidence="3" type="ORF">BQ5605_C017G08562</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY20274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NYM5"/>
    <dbReference type="STRING" id="796604.A0A2X0NYM5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047865">
        <property type="entry name" value="Ribosomal_uL10_bac_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY20274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="273" mass="29681" checksum="F538A94D3B81DED7" modified="2018-09-12" version="1">MPRIATRIIRALVTTPSHTSTPLARAYATAANSTCSPSSTSSSHPPQPPPTHARTRPLPARKQLLYASHANLLTSNELVLFLRQNDFTAQEYNTLRTQLNALTGTEPQFKYTFTVLRPGLLSALLRDSTLVQAIEADFLAKDSHTKGALSVLTAKKLDPPTLKKVIKLVNTYSALPFANQPPPEATKGIPEPTPERLKILSALAERKAIEQERVNGLGELPNLHTLRAQLVGLLSSPAGRLVGVLGARADEVKRTLQGFQLGLQEKQEPGNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P0X0</accession>
    <name>A0A2X0P0X0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C001g00851 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C001g00851</name>
        <name evidence="10" type="ORF">BQ5605_C001G00851</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY50045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P0X0"/>
    <dbReference type="STRING" id="796604.A0A2X0P0X0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF1">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016022766" evidence="8">
        <location>
            <begin position="21"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="76"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY50045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="475" mass="50410" checksum="F6A9BE1BB200F978" modified="2018-09-12" version="1">MRITFAVTATLSAVTTLADAYPHIAEYLAERNSRRQAIPTVPFPKASAHDQGEIGGVPRVLPIGFNADAQRVSTTGDHAFIAPGPNDRRGPCAGLNAAANHGYLPRDGIATYAAVETGLWEAFGLDQTATQVLQQTTTFFDGDPITQKWSIGGFSPKTAALAPVGDLLGLPLGTALSKESGICGYGHLKSEGDASITRGDFLAPTMNSNCASYPKFFQELLDTSCEVNKDCLITMDSLALHQHRRKLYSINTNPNYFSPAFAGVAFTPAAHHFVFALMANRSSEHPEGLLTPEALMQWFSYSRDGSGKLVYKYGNERIPDNFYKRGLQDPWTLPDILTGVVQQCLAYPTTCAIGGNTGKVNSFAGVEVGDLSHGLYDSSAFTDPAKLGCFLSMNIQAEAPSFLSNVLQGPVVQTVLSLLTSTLIPTLAKGFGECNGINVKGGNGAGVPFGQYSGASQFPGAVVQNDGPRGMSPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P2C0</accession>
    <name>A0A2X0P2C0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C002g01659 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C002g01659</name>
        <name evidence="3" type="ORF">BQ5605_C002G01659</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY34615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P2C0"/>
    <dbReference type="STRING" id="796604.A0A2X0P2C0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05014">
        <property type="entry name" value="SIS_Kpsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035474">
        <property type="entry name" value="SIS_Kpsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38418">
        <property type="entry name" value="SUGAR ISOMERASE, KPSF/GUTQ (AFU_ORTHOLOGUE AFUA_6G08860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38418:SF2">
        <property type="entry name" value="SUGAR ISOMERASE, KPSF_GUTQ (AFU_ORTHOLOGUE AFUA_6G08860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="211"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY34615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="549" mass="59036" checksum="A71C9FB102A4336D" modified="2018-09-12" version="1">MSSSFSTSSLTSGQHQHQQHPSQQPQPQQHQWSRHDSVSSVTPACLFAGQSDLSIASLSESPFSSSSDSDQASSPRSVASSSAPSPTSSIASSPFLSPAKGLSLSPVLDQLSLSGSQLDLDPLKPNPTQLAAYASSIVRNEAYALLALAARLAPAAQPIVEDEAPFAHHDLFPGPGFGFEDHASDVSSLDNDDSSVESRAESRSNIAFRNVIDALSSLPAHGKIVVTGVGKSGLVGRKMVATFCSLGIQSVFLHPLEALHGDLGVICRCSPTSPCDALLMISHSGATAELMRLLPIIRPRVRTLIAVTRDPDSVLARACAGWLDAGTGASTKSAGEKVTDEADSALPAPTSSVVAALAIGDAVALTLNKMRIGWGRDGKARREDFLRCHPGGQLGIELNEAFENLNVRVRASLAFPATSRRRRLCHHRQYPTFSARLALTKRRGPDIDLFDDDFGRMAPLLDLSWLTDEPLELESLARPLDALRDKLKIVEQSLRRVGKATRLSLSAAFRRRIWRHMDHAERMRSVVLSSQEALEVMPSLLVEEQLPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P2W7</accession>
    <name>A0A2X0P2W7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C007g04528 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C007g04528</name>
        <name evidence="2" type="ORF">BQ5605_C007G04528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY61124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P2W7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="269"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY61124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="363" mass="38934" checksum="E8F4348E6D67EA5B" modified="2018-09-12" version="1">MSEATSPEAMPSPAPITTGKAEKVYETVSDPQKLWPVPGTRWDSPKDLLLVMQLATLAAGYSATANLASRVTPTATAHAFIRCIEAKTPNSGGCQSTLAVLQYANAKNPHGTCRVQLPPKAGKSAKPSLKDHHSHPDSGHLKVGDVIQPAEPPMSLEVGPTVYTLSDINKLEAYARADSRRDPHNAVITVVRSKDILFKCRGKNDNDDACTWQIRLTPTSAGAKTYTCKEIEPDHTCEPAHPAPSAHLNTVLDYFPSLHLKQGLIGKSKLQQSRKIQKQQQAKAPRKREPIEPSDDEDEEEEGVLSDSGLQQLCDKLIVFCPPVPINSLGAQPAKRLRSSASPASLSDLSDGDAHSIGGAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P2Z8</accession>
    <name>A0A2X0P2Z8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C003g01980 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C003g01980</name>
        <name evidence="25" type="ORF">BQ5605_C003G01980</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY38218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="409"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="1208"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="712"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1478"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="2310"/>
            <end position="2452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="1531"/>
            <end position="1563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="23">
        <location>
            <begin position="1566"/>
            <end position="1583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="2388"/>
            <end position="2398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="2407"/>
            <end position="2426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="23">
        <location>
            <begin position="2427"/>
            <end position="2438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGY38218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="3026" mass="329098" checksum="5A4ED79A2F520C94" modified="2018-09-12" version="1">MRYGAVSAVDLLPVISRLFSPDPMPDTADEFLQFRDRFENDSRLLDDSKVTTDSLLASHLLARMPSSLSTWRTMFVNSQGTSRTLPPAAQILDRIYRKIKARPVDSPVVKGTRSLSSLTDSEFKQKGSNGVIAGEDKLLKRLSRALHVATTTTSQQRVPHSPCPNPSCRKMHWLRDCPDTAWAAAGATLRNHKKGSRAVASPAVDEKPEPATFTACLLATPSAFPKSAWLLDSGANRHMANDSQLFSTLRPFAGPHVAGVAGSLPSTGCGSVRLLTSAGPVVATDVLLVPSLPCNLLLVRCLDRLGFTTSFGSGRVTIRNSSGTVVATAQAITNDLYVLTVAPSPCMPNALLATPHRVSLLTMHRRFAHLPVAQLKSVVQKGLVTGVDWVYSEEEVRSFNCNACLASKVHALPFARSKSIASGRLDLVHVNVAQMPRASFGGHRYMLVIVDDYTRKHWCILLTHKSDVFHRLCAWILEVENATGDRVKTIRSDNGGEFTLRNFVDFCVAKGIRRELTIPYTPQQNGRVERTNRTIKEGILALLYLAGADTRLWAEAATYFVHCKNLMPHAGIRGDIPDTRWYGIAPDVSSLRAFGCRAWHCLPSVKRTALDPKAVLLMFVGLAAGPAARSPEPTGSALLFLLLKQLLGLVSLVRRSEPYHRLSSRRSFIGYKPIRPTSAATPVSALACRFFFAPFARPSLARRSARLHMPAADDTDTAGDTNSVGPTTTLAVPPPRPPTQVAAFAASDLLRDANGYQDWVLTLCSRLPSDVLDYLESGVPHPSWPPSYVPLWDHYARASICAAVEPRMVLPGLARYFGDPHSGHKIWVALRTRYGAVSAVDLLPVVSRLFSSEPMPDTSDAFLQFRDRFENDSRLLNDSKVTTDSLLASHLLARMPPSLSAWRTTFVNSQGTSSTLPPAAEILDRIYREIKARPVDSPAVAVAASQQRAPHGPCPNPSCRKMHWLRDCPDTAWAAAFRARKASAVATSRGHKKGSQAVASPAVAEMPEPATFTACLLATPSAFPKSAWLLDSGANRHRANDSKLFSTLRPFTGPHVAGVAGSLPSTGCGSVRLSTPAGPVVATNVLLVPSLPCNLLSVRRLDRLGFSISFGSGCAKISNSSGTVVATAQAVANDLYALDVAPSPCMPNALLATPHRVPLLTLHRRFAHLPVAQLKNVVQNGLVTGVDWVYSGEEVRSFNCNACLASKAHALPFARSESVVSGRLDLVHVDVAQMPRASFGGHRYILVIIDDYTRKQWCILLAYKSDVFHRLRDWILEVENATGDRVKTIRSDNGGEFTLRNFVNFCLAKGIRRELTIPYTPQQNGRVERANRTIKEGILALLYSAGADPRLWAEAARYFVHCKNLMPHAGIRGDIPDTRWHGVAPDISSLRAFGCRAWHCLPSVKHTDLDPKAMPLIFIGLDDHAKAYRLFDPVTRKIILSCNVVFRESEFPALQPVADTQTGATPLSVAADIYPDQVDHSEPLPVAPPCSLAPRAELPGPVPAASDQGLRRPSPARDIPDQDSRAPPASDQGSPTSQAGDHFNQDSPTSCASDQGSSDSATSMPCPSPQPVAPCPLPAPPSPAQSVSADPINLLPRSGDVASICLAQDFPDDLDAALHSPSPVAYLASGAAALLSTSLADPSELIAPARDPPHWRAAMATPQADEWRLAAQAKFDSLSRDFSAFTPIDESLVPVDSKVLGSRFVFRTKRDQHGRIKSYKGRLVARGDSQRSGIDFDETFAPVAKFTSIRALLALAAAHGYHVHQADIDKAYLHGKLDTPLYIRVPEGIYMPGKVLQLHRSLYGLRQAGRIWNDEIDSALSALGYVATESDHCVYVRTAGDERHYIALYVNDLLMISPSLPEIERTLQGLEQRYGVKRLGEAEYVLGIQIRRSADGPISLSQEQYLKDVLARFGMSDAHPVATPMQADLRLEVELQPTPFPDRTRYLQAIGSLMYASTGTRPDLAYTVGYLARFSQSPSAAAWGAVKHTFRYLAGTLSHGLRYACGDPAPLVGYSDCNWGACVLSSKLTMGYTFVFAGAAVSWSSRLQSRVADSTCDAEYLALSHAGKEAIFLRQLFGELGLPSSQPALIYGDNQGANALTKNPVFHARTRHIRLRKHFVRDMVSLGDISFVSRPVCSASRSTWCLLSLILEVGGVSLPFWAGSVRLTQAAGPAARSPEPTGSALLFLLLKQLLGLVSLVRRSEPYHRLSRCVIKQLLGLVSLVRRSEPYHRLSRCVIKQLLGLVSLVRRSEPYHRLSSRRSFIGLDDHAKAYRLFDPATRKILLSRNVVFRESEFPALQSVADTHTGTTPLPVAADIHPDQVDHSAPSLVASPHSLAPRAEPPGPAPTASDQGPCRPLPARVLPDQDSRARPASDQGSPPAPDQGSLPASDQGSPINRTGGLPDQDSPNTYASDQGSSDSAISTPCPSPRPVVPRPLPALSSPARSESPDPIDLLPCLGDIASVCLAPKFPDDLDDALHSPPPVTHLASGAVALLNTAPTDSTELIAPARDPPHWRAAMATPQADDWRLAAQAKFDSLSRDFSAFTPIDESLVPADARILGSRFVFRTKRDQHGQVKSYKGRLVARGDSQRSGIDFDETFAPIAKFTSIRALLALAAVHGYHIHQADIDKAYLHGKLDKPLYICVPDGVYMPGKVLQLHRSLYGLRQAGRIWNDEIDSALSALGYTATESDHCVYVRAASDEHHYIALYVDDLLMISPSLPEIERTLHGLEQRYGVKRLGEAEYILGIQIRRSNDGSITLSQEQYLKDVLARFGMSDAHSVATPMQPDLRLKVELQPTPFPDQTRYLQVIGSLMYASTGTRPDLAYTVGYLARFSRSPSAAAWGAIKHAFRYVAGTLSHGLRYTRGDPAPLVGYSDCNWGACLFSSKSTMGYNFTYAGAAVSWSSRLQSRVANSTCDAEYLALSHAGKEAIFLRQLFGELGLPSSPPVLIYGDNQGANALTKNPVFHARTRHIRPCEHFVQDMVSMGDIVVQYIATSEMTADIFTKALSCDLFAQHRGQLGVCAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P3I4</accession>
    <name>A0A2X0P3I4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C007g04778 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C007g04778</name>
        <name evidence="3" type="ORF">BQ5605_C007G04778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY63150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P3I4"/>
    <dbReference type="STRING" id="796604.A0A2X0P3I4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23795">
        <property type="entry name" value="UBCc_UBE2G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY63150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="189" mass="21324" checksum="44F9CF438407ED07" modified="2018-09-12" version="1">MLLSRIGRFPISQLTKHPVEGFSAGLIDDDNVYEWEITIFGPPDTLYEGAFLRATLTFPQDFPLRPPKMKFLTEMWHPNSAYATRDTAETSMLTTLNRPCTVYKNGEVCISILHEPGADQYGFEDASERWLPVHGVESILISVISLLSADTPNTDSPANVDAAKEVREDIQGYRKKVRRLVRKSAEDCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P3R4</accession>
    <name>A0A2X0P3R4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C003g02191 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C003g02191</name>
        <name evidence="3" type="ORF">BQ5605_C003G02191</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P3R4"/>
    <dbReference type="STRING" id="796604.A0A2X0P3R4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050312">
        <property type="entry name" value="IolE/XylAMocC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110">
        <property type="entry name" value="HYDROXYPYRUVATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110:SF21">
        <property type="entry name" value="XYLOSE ISOMERASE-LIKE TIM BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015964127" evidence="2">
        <location>
            <begin position="18"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY39281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="388" mass="42665" checksum="CB4F280B3ED3EFF4" modified="2018-09-12" version="1">MPSPLHLFLPIAPPSLALISCCSFFDLDLDRQPPLHHAVNLLLAGFPCGHSAVQDVMTGINDESTTLSTKTASTGNAAGQVRLEDGDDGAEVGMCGGSLCLLFPLVFFSRARIRPRCTATPTESEINRYWNVEHHTLIRFQHIELFDDDWAAFRDSWSEAQGLSKSTRDGDSTSQFAAAALAHLVRSYGLRISCWQPLRTFEGYVDAEDRRKSRDFARGILDILPILGTRLLLCCTTTTPAPATTGDLHRCAEDLVWLADEAAKCDPPVRVMYEGLSFAAHRRKSSKRRIDPTSASAWTRSIPSRSNGPILTHQPGAFPPTWMRSCKPICANWFNGYPVTRSSSTKSPMPSPMPSFKPVTMDLGHSRSLTNPSRAMIPMSLSSMQGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P5S3</accession>
    <name>A0A2X0P5S3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Glucose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3 10">5.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C005g03323</name>
        <name evidence="11" type="ORF">BQ5605_C005G03323</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the GPI family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="3 10"/>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY73863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P5S3"/>
    <dbReference type="STRING" id="796604.A0A2X0P5S3"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051156">
        <property type="term" value="P:glucose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1390.10:FF:000001">
        <property type="entry name" value="Glucose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000004">
        <property type="entry name" value="Glucose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023096">
        <property type="entry name" value="G6P_Isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001211">
        <property type="entry name" value="PRK00179.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469:SF1">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00765">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY73863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="580" mass="64209" checksum="24BFE3733DCB624C" modified="2018-09-12" version="1">MSGALATDYPAWATLQSLYDKNHASLVLKDLFAADPERFSKLSQAYDNSAKDVHILLDYSKNLVDDNVLDALFQLVKQAKVEQARDDMFKGKHINTSEDRAVLHVALRNVGSEFKIPEAGADEVQGVLDHMTEFSNKIRSGEWKGYTGKPIDTIVNIGIGGSDLGPMMVCEALKPYGSKNFKMHFVSNVDGTHIAEVTSECNTETTLFIVASKTFTTQETITNAESAREWFLKSAGDKSHIAKHFVALSTNTSAVTSFGIDSANMFKFWDWVGGRYSLWSAIGLSIMLYIGPENFKDLLLGAHEMDKHFLETPVEQNLPVILAVLGIWYNDFFGAQTHALLPYDQYMHKFADYFQQGDMESNGKFVTKDGRRVTYQTGPIIWGQSGTNGQHAFYQLIHQGTKLIPADFLAPIETQNPIRNGLHHEILLSNFFAQPEALAFGKDEATVAKELGAQASNEALLKSKVFEGNRPTNSIMFQKLTPKTLGASLILKPCTISSSLMLHCDLFCAGSLIVMYEHKIFTQGCIWGINSFDQMGVELGKVLAKAILSQMDDPNKVTGHDSSTTGLIKHYQSKRAAKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P7E8</accession>
    <name>A0A2X0P7E8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BQ5605_C008g04964 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C008g04964</name>
        <name evidence="12" type="ORF">BQ5605_C008G04964</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY78825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P7E8"/>
    <dbReference type="STRING" id="796604.A0A2X0P7E8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033215">
        <property type="term" value="P:reductive iron assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13877">
        <property type="entry name" value="CuRO_2_Fet3p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13899">
        <property type="entry name" value="CuRO_3_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044130">
        <property type="entry name" value="CuRO_2_Fet3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF361">
        <property type="entry name" value="IRON TRANSPORT MULTICOPPER OXIDASE FET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015936932" evidence="8">
        <location>
            <begin position="19"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="569"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="11">
        <location>
            <begin position="27"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="160"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="378"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY78825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="630" mass="68930" checksum="5681ED448898C671" modified="2018-09-12" version="1">MLANAFLTGLIAAGSASAAVHEVWYNITSAKANPSGLFERSVVGVNGTWPPPALFVNENDTVIVHATNLLDHPTAIHHHQLHLISFQGMYFFNTSYYDGAPGVTQCGIPPKATLTYEIPVSVDKQWGTYWWHAHVDQDYVDGLRAPFIIRPTTEVHQYDDEYTIVLSDWYNEQHSVLVDQFMNWKNPTGAEPVPDSAAIYVADRNGNYLSGFNENVTIPFEAGKTYRLRFINAGAFAMFNFWIDEHQMQVIEADGTDTDPHPVDYLGISVAQRYSVLVTAKNTTNSNYLLHANFDVDMFDSYDADVLQVNYTSTISYGASVTAAGAVMPPFRRTPDQDLVPSIVEASLDANREIELGVFFATFDDGINRAAFNNITFTHPSVPSLFTQLSMGENASLPGIYGPQTHAIVLQKGEIIDLRVVNWDGNAHPFHLHGHKLQIISVTADSTSNDTSINPPIPSSLPNPMRRDTINVPGEGGAVTLRFPVDNPGTWMFHCHISWHLTAGLAVIFIESPAESQQELVIPQVMKDQCAALGIPSAGNAVGKFSTTDLAGVARGPYPQVLGWRPKGIGALAGCIITALLGMVTVVWYALGGQLDDEELEAEVDRELEAKKNGGLIKRGARKLFGSSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P7H2</accession>
    <name>A0A2X0P7H2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g03821 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g03821</name>
        <name evidence="2" type="ORF">BQ5605_C006G03821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY53945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P7H2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY53945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="105" mass="11526" checksum="801E9AA5DC889596" modified="2018-09-12" version="1">MKRKRKKINVLTAEGPPHSHFPLGRDKDKSTTAQPPRPLTLGFFLFLTGAHKLQSFGLAGTATKRAKEGYKATMASSWVKVKPLRAKSAAQIKTRRAPNADSNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P7Z8</accession>
    <name>A0A2X0P7Z8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C008g05204 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C008g05204</name>
        <name evidence="1" type="ORF">BQ5605_C008G05204</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P7Z8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY79702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="124" mass="14140" checksum="C446918E0C22730D" modified="2018-09-12" version="1">MLNIRGTMHCGIPAFGNQRFTVPSRLFVSRLSHLPRAPHHTNPPSYTLTMSFALAHNRPLEIMHLYFDDKQEVMATCLLATNETVELVSVVSISDRRVILRALAHELLWSVIRTVYFLEVLPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P8F8</accession>
    <name>A0A2X0P8F8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C006g04132</name>
        <name evidence="3" type="ORF">BQ5605_C006G04132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY56399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P8F8"/>
    <dbReference type="STRING" id="796604.A0A2X0P8F8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="82"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY56399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="411" mass="45632" checksum="2A0E9646ADB5C43D" modified="2018-09-12" version="1">MQHSYEFENSLQHVLFECQLSSCFFTVSCGRIDFVRLRIRVHGTQNILNGSVRWSDRCGGRWDPKQCLPVIPKSSSTQIVDFVDAPGGTGKTFLEETVLARIRSEGTYALAVASSGIAALLLPKGRAARSRFKIPIIIFGDLYVQPPMQHRRCFQRVGRMLQNVGSSTARFGGLTAVLAGDKFSQEAFPQFPSHRLLKSSTLASWNTDFLGGSSDCVNCGSPSRGRFSTARFGGVTVVLADQQCVFWLLAAADRMTETEQAKAQRFADFFGVGDGLASKTEDFIALPRELLLPATTRNRSGLIRHVYPVPALELDNMSIGEKVEYFRERAKVAPKNSQVDHINDMGLDLLPGDAQTFYSADLIENEDESLFLIEYLQSLNITEMALLHTRRGSRRRSEPIIGLPENKKGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-11-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P9B0</accession>
    <name>A0A2X0P9B0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit H</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C007g04483</name>
        <name evidence="7" type="ORF">BQ5605_C007G04483</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase H subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY60772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P9B0"/>
    <dbReference type="STRING" id="796604.A0A2X0P9B0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.150">
        <property type="entry name" value="V-type ATPase, subunit H, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004908">
        <property type="entry name" value="ATPase_V1-cplx_hsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011987">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038497">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11698">
        <property type="entry name" value="V-ATPase_H_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03224">
        <property type="entry name" value="V-ATPase_H_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032184">
        <property type="entry name" value="ATPase_V1_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase V1 complex subunit H C-terminal" evidence="6">
        <location>
            <begin position="317"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR032184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY60772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="442" mass="49156" checksum="0D12D7885E907162" modified="2018-09-12" version="1">MISNVYLSDRSLKIRSKAIPWEGYQRAGLLSQDDVALIQRVAGGKAQAESVLQAESDTYADLYVRLLSKLSRNDTLQYILVLVADFLNDRDDRIPLFLSQNDPYSPLLKHLDSQDDFVRSKSAAVISTVISGDPNPPDAVVTKVLTALSALIRNQADPEAQDVGVQCLGSALRIEKIRTAAWQADSKDGAESSKAIKGLVQLLKTNPSAQMQYQLGFCFWLLTFDTPIAEKINARRNIIPLLADLARQALKEKVIRIVVAALRNLVTKAPTENLPAMLVAKLLPFVKTLASRKWSDDEIKEDVEFLVEELTKSFEGLTTFDEYKSEVQSGQLSWTPPHKNDDFWRDNAAKLNDKERELLKYVSHDTKLALVNMLATAQEPLVLAVAANDIAQYVKFCDTGKKSLDSLGAKGRVMELMNHADPDVKYYGLLATQRLISHAWAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P9H7</accession>
    <name>A0A2X0P9H7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C009g05785 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C009g05785</name>
        <name evidence="2" type="ORF">BQ5605_C009G05785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY85872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P9H7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016082721" evidence="1">
        <location>
            <begin position="22"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY85872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="92" mass="10112" checksum="CF65BE0B753B3764" modified="2018-09-12" version="1">MHSSIRIAFLVVAALTSTVLASFVSKDGNQYCTSLNEKCNICIADCEPAFDNPNYQICIRKFCKGPNKYCTKYQAQSKNAADCMMAKRSVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P9N2</accession>
    <name>A0A2X0P9N2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C137g13406 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C137g13406</name>
        <name evidence="3" type="ORF">BQ5605_C137G13406</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000053">
        <property type="protein sequence ID" value="SGY88782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P9N2"/>
    <dbReference type="STRING" id="796604.A0A2X0P9N2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22748">
        <property type="entry name" value="OTU_OTUD6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF10">
        <property type="entry name" value="DEUBIQUITINASE OTUD6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="2">
        <location>
            <begin position="315"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY88782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="528" mass="57838" checksum="B6B5EAA919AC3747" modified="2018-09-12" version="1">MATVVDSSQGPSSSQAPTRSESLTSSLNPLLSRGKLNKATPSKKKKETKKKDKTKINPEQTVVGASTSTSSSAVTPTGTGTGSTKSPRGGAVGADGDEDDEASDLADQLLSQLEATRNAASPEATSSPSSAAPPSTSTPSTTTTSSSRTSVSSASTSKREKLHNLSDDMRHLLLPNSQGKDKDKDKDKDSGRGGLFASQGMSRQKMRKMRKEKELEQIKHHAQQEVLHANDNSIEEERQAMHEDVRAWASGSKRSIRMGIGAFDSSWGTMIIWSLTLRPYNSLYSAIADQANHLRLSVRIFFCTRQRHFTADLALTIQQTTKETYLTTRKHAAAYMRGHPDDFLPFLESSDQAEALMTPEEYENYCATVENTAEWGGEPEIRALAKHYNVQIHVLQAGTDLLKVGEDDLPLGPAGPIRISYHRKMYGLGEHYNSLVPATYAPPAVGVCDPIARCMIMSVRSRDTYEDRVETLDCNTALRTTFMRKLVDRLLAHPLQQASKTNPSSHEQYEDPGKENRPEKQPFGGGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P9Z0</accession>
    <name>A0A2X0P9Z0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C007g04652 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C007g04652</name>
        <name evidence="3" type="ORF">BQ5605_C007G04652</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY62105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P9Z0"/>
    <dbReference type="STRING" id="796604.A0A2X0P9Z0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053027">
        <property type="entry name" value="AGGF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23106">
        <property type="entry name" value="ANGIOGENIC FACTOR WITH G PATCH AND FHA DOMAINS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23106:SF24">
        <property type="entry name" value="ANGIOGENIC FACTOR WITH G PATCH AND FHA DOMAINS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="168"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY62105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="519" mass="56178" checksum="5BC03B5FFBAFA510" modified="2018-09-12" version="1">MASSSQWIWDPTYSLYYNPSTQQWARIGADGEWVYASATLHQQPHDSAKANAAEAGDVRASAAAYARSARSGGSSSAAAKGKRSYYDRDDPDTPGELSYAPAVPEEQVWPFSGDEHDDGPLREAGKWTHDRYDPGLDELAAPILRLVVDRSGVLQKDRVILIPPDEPVQVGRDKAFDKRIRLKELQVSKTHATLFFTPLDAGGDGGEWQVVDGGSTQGTFVKATSSTGEWVRLSRDKVASEPRTLHHLEWVNYTLHLLRIGTTSFSIHIHASLPCSTCSIKTDESNLIPLSTSEDHQPTSTTTDGPTSLGPTPYTAVTKEQKELERRERMKGLKEQYRIGPGLKNSTVTPIEGKDGVDPSSTRPAETPFIDRAKIRRERNLGADEVATKTSKQITSAPFFTVPGANAAHSIVSASSTTRPIDPFGSESKGAKLLAKVGGAGSSTPTAASASTTTMATPRGLGQLIDPKVLNGDAKSGLGSRPLKTLLQPVVIHDAKQGGWREDVREASRKRWKEMEGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PAA3</accession>
    <name>A0A2X0PAA3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C007g04772 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C007g04772</name>
        <name evidence="1" type="ORF">BQ5605_C007G04772</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY63085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PAA3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY63085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="65" mass="7378" checksum="2E6554EDFC902925" modified="2018-09-12" version="1">MPNRKKFPIPATVVIRHPLPPLDQSTINIDEMPNAHPAAWRLSVDSSRLRKCNKIIISRLGDYMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PAT9</accession>
    <name>A0A2X0PAT9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C004g02766 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C004g02766</name>
        <name evidence="1" type="ORF">BQ5605_C004G02766</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY67340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PAT9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY67340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="66" mass="7166" checksum="77E2C116EF832DA1" modified="2018-09-12" version="1">MSLPPHNKDDPIPGTPRRTVDAVKHIRDAFQDGVLTADARKDLLSQVASDIGSLIVLRTVPPPRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PCA4</accession>
    <name>A0A2X0PCA4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C005g03217</name>
        <name evidence="11" type="ORF">BQ5605_C005G03217</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY72830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PCA4"/>
    <dbReference type="STRING" id="796604.A0A2X0PCA4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000578">
        <property type="entry name" value="probable ATP-dependent RNA helicase DHX35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000145">
        <property type="entry name" value="probable ATP-dependent RNA helicase DHX40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF136">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX35-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="88"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="312"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY72830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="768" mass="85565" checksum="4F2D1D3B07B29E70" modified="2018-09-12" version="1">MSFWKPGTVAPGSSIDRDGDSSAAEGGAGSSVGAITGRVAHNISVAERRYRLPIAKQTLIFPTFNPHFFYSIPTSDRREHANAEDALLYLLEHHPVVVLQSPTGTGKSTQLPQFLLEAGWASEGKSIGITQPRRVAAVSVAQRVAEEVGSVLGDQVGYSIRFEALCNPETKILFLTDGMLFREILLDPLLSKYSVIMVDEAHERSTYTDLLLGVLKKIRRVRPSLRIIISSATIDAQSFVDYFNTFPLSSSVASSGINPKDDSHLPPPAKRSRWDDKRKPAKSEAVMVRLEGISYPVDIAYLEEPAADLVFKVVETVFDIHLKYPPGDILVFLTGRDEIDRCLQQLADNMNRMPSGAADLRVLPLHSGLSTEAQMAVFQPPPSRTRKVIVSTNVAEASVTIDGIKYVIDSGLVKLKSFNPLTGMDALVTTPCSIASLQQRAGRAGRTSPGKCFRLFPSSVLPSLLPTTPPELTRSDLSLVVLQLRLLGIQNVLRFDWMNPPSSAMLERALEFLFCLGALDDEGKLTKPLGERMAEMPIDCMMAKILLDSAEFGCSNEILTIAAMSSVQVSDRLTVKMHKTSQHCCHVSQNVFIMDEGDSVRHELERRKFIVEEGDHLTHLNVYNAFVKHGRKASKWCHTYRLNFKALSRALSIRTQLKKYLQRFEIPLISCGTDHAKVRRCLTSGYFRNCARVQPDGTYRSVRENALLHVHPSSVMFTRTPLTPYVIYHEVIETTKRFMRDVTSIEVEWLTELAPHYYSFKETESAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PCJ0</accession>
    <name>A0A2X0PCJ0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C005g03428 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C005g03428</name>
        <name evidence="6" type="ORF">BQ5605_C005G03428</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY75482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PCJ0"/>
    <dbReference type="STRING" id="796604.A0A2X0PCJ0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14483">
        <property type="entry name" value="SPX_PHO81_NUC-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057506">
        <property type="entry name" value="C2_GPCPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25329">
        <property type="entry name" value="C2_GDE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SPX" evidence="4">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="392"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="425"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="458"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="494"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="563"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="596"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="5">
        <location>
            <begin position="832"/>
            <end position="1126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY75482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1126" mass="121885" checksum="5CFA92CE3684E317" modified="2018-09-12" version="1">MKFGKAIVEQALPGWSAFYCDYKSLKKIINSLAKGRPADAALLAAGVRPPRPAGPEEPLHPSAEPQLLAHSASVTSGNGGQGSLLQAHKAAFFYKLERELEKINNFYYQREAALKVRLRTLIDKRKLLTASLSDSSGKSKVLSRESSIYGALHEGFRNFERDLGRLQAYIELNATAFRKICKKWDKACRRQADRFGDARPQQGEHDGQLYLARQVEVQPVFNREFIAELSDGELQWCIQRCLPSLTQRGHTTVASANLLSLEILAGSEGKHRGDALADGADIEQLGAGAHTQRIWAMDAEADSTEALEDLEQALVTAVKMGDAAAARGILESLAPLPQKDGIKAPVSRILWRATLEAEAGTTESIASESVAGSPHSLIPFSLLDFAFVDDISGRTTLHETASAGKLELVKACLQNGVSISQADVYGRQALHYAAINGHSAVGHLLLSSGADATVLDFDGYSPITYAITNGRTQVVQTFIDQGISFDTASSTTNEDLNALSLASQHGHEDIARILLSKGAQILPSPAGYWPQHLAARQGHAGVLRLLVEATRGFAGIDLPDKYSQATPLHHAASHGHAASVQVLLHAGSNVHSKDEFQRTPIHYAAWHGYIDCVNLLLAAGANMVASLPIDHPLLANTSNATGPMSSADLEPLDLESDLIPSLSLPPPIIPFRIYGHSFLDKKCLVQICLGHPNTSCAPFPPPIRLADKGGRGQQPSLKLVMTPKPESIAVPHSVILPLADEREVFPFQVESFDNFSLEFDLFPTFGSKVIGKAVAAPSTFDSLQSQGSYVIPLLDPHLKVIGDIPFEINVVKPFERATLQLGGQFETYWRSMTALNPSGDPAPTPVTGGASVVTASSLSGEHVRVIVQVTSDGVPVAYPQWKLPLEGFDVHVGDVTFAQFESLAQRTARRLDPARIADPADPVSWYQAVSGSLVSLDEIFQALPASFGVDLEVRYPTRSDMRRLNIHHSLEVNQFVDCVLSTVYEAIQNGDEKHHRRIVFSSFNPLVCTALNWKQPNFSVFFASYCGISRSNSSGQLVPANRVEDDRRCTSIREAVKFAKTNNLLGVMLDATILLKVPSVIQSVKEQGLLVTTFGPDVPAGWADAHMASGVLSYASSAFLQRTEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PCL0</accession>
    <name>A0A2X0PCL0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C005g03347 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C005g03347</name>
        <name evidence="10" type="ORF">BQ5605_C005G03347</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY74192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PCL0"/>
    <dbReference type="STRING" id="796604.A0A2X0PCL0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF67">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="167"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="532"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY74192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="791" mass="88028" checksum="510F5C6391A466D6" modified="2018-09-12" version="1">MAPAQSKLARTTSSLPGGSASLAVPLLVALYYLRKRITDAATKANLRGVPLTTPQLEMAQRDLYKPRVGFYDVLSRGARELLVPSRGRVSKVLIRPTKQSTFEAHRPFFRAPKNTPAASTTSAGTRAQTARVGVNKEFFRQISAIFKIIFPRLTSKEVFLVATHTSFLLLRTYLSLLVAKLDGRLVGDLVSANGKGFIRGLGLWFALAVPSVYTNSMIRYLQQKLSISFRTRLTRYVHDLYLSPKNTFYSIVNLDGRIEGADQFVTTDIARFCDTLSALYSNISKPTLDLILFNIQLGRSIGAKGSGGLLVSYVLTAWILRKVTPAFGKLAAIEAKLEGDFRNAHSRLIINAEEIAFYDGASIEKDILNRAYLRLIKHVNSIFKIRILYGMIEDFIVKYMWSACGYCLISIPVFFAPKHTGAENSVETAETDGRKVAQRTESYISNRRLLLSLADAGGRLMYSWKDLSELAGSTSRVYSLLSTLHDLDAKRYQSVPRPVDLAACKPFYDLGSVTGKLMLEPRSTALNEPVAVSFDDVPIVAPAPGMARGGEELIKKLNVKIHRDEHFLITGPNGSGKTSIARVLAGLWPAFEGVVTRPQDEDIFFLPQRPYLSAGSLRDQIIYPHSYPDFVASGRSEAELLNILKHVHLAYLPAREGGLDTRKEWKDVLSGGEKQRMGIARLFYHLPKYGVLDECTSAVSTDVEGMMYQHAKDLGITLITISHRPSLFKYHHHLLRLTGTDGEWETTQIGTAAETLSFQKEIDSLTEKLSDVDTWKARLKEIEKELAFTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PCN0</accession>
    <name>A0A2X0PCN0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C005g03478 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C005g03478</name>
        <name evidence="6" type="ORF">BQ5605_C005G03478</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY76250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PCN0"/>
    <dbReference type="STRING" id="796604.A0A2X0PCN0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023442">
        <property type="entry name" value="Ribosomal_eL24_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01073">
        <property type="entry name" value="RIBOSOMAL_L24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL24-related N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="93"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY76250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="148" mass="16657" checksum="8F6ECB4D2F590889" modified="2018-09-12" version="1">MKVETCSFSGYKIYPGKGKLYIRSDSKVYRFVTSKEESLFLQRKNPRKIAWTVVYRRVNKKGITEEVAKKRSRKNVKHQRGIVGADLSSILAKRNQKPEVRTAQREAALQAGKDKKKDKKALKSTPGAKPVAAKQARAKSAPRTGGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PDU8</accession>
    <name>A0A2X0PDU8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C008g05109 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C008g05109</name>
        <name evidence="9" type="ORF">BQ5605_C008G05109</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Mitochondrial ribosome (mitoribosome) assembly factor. Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body. Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PDU8"/>
    <dbReference type="STRING" id="796604.A0A2X0PDU8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052571">
        <property type="entry name" value="Mt_RNA_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015324">
        <property type="entry name" value="Ribosomal_Rsm22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184:SF5">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09243">
        <property type="entry name" value="Rsm22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="437"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="474"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="537"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="537"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY79339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="602" mass="66590" checksum="EF757AE76EFE3BE7" modified="2018-09-12" version="1">MNAVKSRLTQRSIYTTLRHASSSAIDRLHLDINAGAYRDESNAPKAAHQETITRSKAATIGQATRWDVDLPIELVRAVDQLVDEYEGEKSSIRTSALELYEHLRSTSSLLPNHVTTPSPSYTPLNSLAYLSGLMPSIYAATVHVLEMTRQRIGWLKGEEGEWVPDRVVEFGSGTGSGAWAARRVWKDSKVEVEYIGLDKDKSMVELGSRIIGALPKRMVDLDLRSDEIEVTDGGEDLSPTTMSAKMHQLAIPASVSSFARLGIPLNPKSQSSKSWNQTLVLSSFSLGDLSSREKRKEFVRSIWETGAKVIVIVERGTPRGSRIVKDAREQLLMYGARDAEKVVSEEGSEKDVDVDRGCFVLAPCAHDGACPLHRSTNMFCHFAQRVRSPAFHRATKHSSQGQEIARFSYVVIKRGTRPSTPPPASLFTKDLLSTSLVADSSPPASTTPSTSTRWTWPRIISPPSKRSGHIILDVCSPPSAQDRSSSSSSGRIEQHIIPKSQGRQAYYDARKSSWGDSFPHPPKNGPVPIQIHSDGLKLGKAKKESRTNKQGWKEKGRKGWKRKEREAQEMEDFGQVLGDEADGTGVREFQLNLGEDGKFYQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PF26</accession>
    <name>A0A2X0PF26_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BQ5605_C023g09694 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C023g09694</name>
        <name evidence="11" type="ORF">BQ5605_C023G09694</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ24060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PF26"/>
    <dbReference type="STRING" id="796604.A0A2X0PF26"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF3">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015942658" evidence="9">
        <location>
            <begin position="21"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="10">
        <location>
            <begin position="230"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="224"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGZ24060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="467" mass="48553" checksum="EC30CD5E78405A56" modified="2018-09-12" version="1">MYLSSSSFVALGLLSGLATAISTAQIESVFGQGAQGLTGSSTTLPNFALSLVTNSTHALITFNSTSIRPSAVGWMGFGVGTAMANADFLVVWPTPAASYTNGPGWTISHRTTTGENEPKVASTDASLATNTFYTVVEPLSSKPTDSYASVSVLRLLTFPSGYPALSRANSGNLVRTGPNNFIYASSTVAPASADQGAFLTQHNQAHARTSLDLSQAVTIPATGASATKPAAGGATTTGAGPQQTSNSNAGGGLASESSGRTKHDMILIAHAVTASLATMILMPGAILIARYFRTTRWFPLHVAFNSLAVILIIVAFGTAVYVTGGGFGDATHYSVGLAIFIIILVQAGLGYGAHLTRRPDLASGARLPTLTGKSPVRHVHALLGLALIALAYYNVHEGFEQWTLDSDAATKVPKAVTVIYWILLGVGAGLYVLGWVFEGLGKSNHQALRSNENLPTSQMTSAETHRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PFL9</accession>
    <name>A0A2X0PFL9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C024g09916 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C024g09916</name>
        <name evidence="2" type="ORF">BQ5605_C024G09916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ26442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PFL9"/>
    <dbReference type="STRING" id="796604.A0A2X0PFL9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="525"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="601"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ26442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="776" mass="82298" checksum="19CD8AB4D8D795DE" modified="2018-09-12" version="1">MADKILVTYCAVSPRCVDRVIMPARRAQTSSSASSPGALPYPPASASGSRSAPGQPGSVLALDPFAPTSWALDPTTWSSEPHASTSYNPVSDSPFRFSPLPLPSPNLLGVLTPANHTPAIATSSLAANIATTVHPQPVPQEVSPSIHPSSTHSFLNSHDYPASFFSLLTSPPTQTAELGDGTAAGAAGSSSADFTHVTPLPDVKPKLDTPSVLGEGHDHVNLGGMHNSHADGMTNPSLMFEFDPTSTTQNQRQPQFQHHSSHLFNSRPSAYSASPSTSQCYSPAEFANLFALASKSSAFSVPSATVTPLAAAGLEHLSDLDHKGPSVSDSIDLSQSLFERLQSSTSVHLMGGYAPSAFSFQSEFDHLTSGTGGEDTPATSIDETMSSGQDSKAFLDSNGVFLPQSLLDGGLHESDPLGLGRTLMSSPGSNDSNEAELAHSVGTTVLSRSSSRKRKRSRATDEAEQTVEHLPTGQGQGQGQRRSRTSSGNNAATDAERLAPWNRSRRGATELSEPSTSSHATYGDAKSTTTATTTAAVKASTSASSRGSRKKKNASNKTASPEASSRKRGGSEVPAVEDDLTIRPYACNWPQCPARLRSLDQRSSSRSGSSSTSVPIEDDLSTPPSEDVRFRTIRELREHCAEHTRDGLEGGETPFRCALYPCDKTFKSLAGLRFHFQNASANGHFFVSCEDEEPATAEEVPPPKKFKLCVQPSGRSEKCPIRGCAKAFRQPAGLSYHLAHTPNHDVSESMLASFSGTLQSKTKWWFAKVGRTFVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LNY9</accession>
    <name>A0A2X0LNY9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C011g06406</name>
        <name evidence="14" type="ORF">BQ5605_C011G06406</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LNY9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000007">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="12">
        <location>
            <begin position="290"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="13">
        <location>
            <begin position="832"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="11">
        <location>
            <begin position="1144"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGY12154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1233" mass="139309" checksum="5D8DE73573159102" modified="2018-09-12" version="1">MNLEAKKVRHRTKTLELCHTTAPRKPKFVRWKMNGLGPKSLSYIGLTPEASDSEDDNNPSYAPHPFPPLPVSLAGAHGTLLASTLVDSGSPQTFLSEELVQRLGLERRALEQHSKYTLAMQDQVPTVFTCTHFVRVPLELANGLWAAGPTYAEVAPLGKDLAIILGGNFIYRHKMELGLFPQPHLTCKANPIHAIDLLALSSQPCAAAQVAAIAPVSDDEEQLRLAALDHRLRAEFADRFPADIPPVHSYQSPVRHHIELDTPSTVVNLRGYPLPKKYREAWYLLLQEHLAAGRLRPSRSAYSSPSFIIPKKGCDVDPTIAPRWVNDYRKLNKHTIKDRTPLPLPDDILSTCSNAQFWAKIDMTNSFFQTKMAEEDIHKTAVSTPWDLYEWTVMPMGLCNAPATHQRRVNEALQGLLGTICFVYLDDITIFADTLEEHEARVRQVLDALRRAELYCLPTKTNLATAECSFLGHIINRAGVHADPKKVQRIEDWSLPKTVKELRGFLGLVQYLRKFIPGLAEHTAALTPLTRQGLSSIATLWTPNKVRHFKAIKAIVTSLDCLRPPDHSANAAPFWVMTDASNQGIGGVLLQGQEWKVARPIAYWSRQYIPAERNYPTHEQELLAIVEALKEWRIDLLGGHFHILTDHSTLEHFQTQRTVLSRRQARWLDTLAEFDYDLRYLPGEDNIVADAMSRYSFTDPLPTLVAAVSHVKLSDAVKQQILDAYKTDPFCQQAMSNIGSVTSDFKIVDALLYLRGRLIIPSLAPLRESILHDAHDAQGHLGDMKTYQTVQQAYFWPNMSRDVKHYVQQCDSCQRTKARTTRIAGKLHSLPVPTRPMADIAIDFVGPLPANKGFDRVLTITDRLLGYVHLLPACEADTAAEVAARFHEGWHRLFGLPQSIVSDRDKLFTSKFWTALHKRLNIKLQLSSAFHPETDGRSEKTNKTAFQILRALVNKEQSNWAECLAVCEYAINSSLNVATGKTPFELVLGYTPSLAPLARVDGDDDLPSVEELLALRFQACEDARDQLAISKVRQAAQSNKKRQDKPFWAVGDLVLLDSSDRQKRLHTRKRRAAKLMDCFDGPYRIVKAQPEILSYTLQLNGDDAAVPFFHTGKLKTYRKNDTALFPNREPARLGPVDVGGEPEYIMEDIVDERIRAGKQQYLVSWLSWPSDSNSWEPAEALEDTEALDRWERRNEELPVRLESKRHEIALEPHWFRVQTERIKRCNSQAKKDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LQS6</accession>
    <name>A0A2X0LQS6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C010g06163 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C010g06163</name>
        <name evidence="1" type="ORF">BQ5605_C010G06163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LQS6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY14380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="416" mass="48274" checksum="917D793FF7A55C8B" modified="2018-09-12" version="1">MSFTPEGLHTTYSWVAHLDDETPDALHPSLRMRVARELGILRGSWTFDPSLRWMRREKREPVWRYISPEERSGLGIRVELEVVGGGADDRLVAEVRGFEEGMDGNLPVEFDLDFAGDSDALDVMKSLRGKVTVTVTFGNLPSRQMETMMVSEQGSGKDVWDEDICRRLLERERLWRGHQSTPHPFDVRFTFEDDPRPLFENADFLVANSPYWQSMLQGEFLESAKTTDPSSTERTCDYPMHIVRVGEARREDYRDVLVWLRTGHLVNYETEEQEQVEHMGTSSSTLEKLVFDVELGTLVKVSGMYRLALALELESLRGEMLQLLKSQIEAGFELEVLWEELPLEHDDVMEMLVEQLVQRGDWIEGTDGFKILQEWVERGEMGEAGKRALELLGKRFEKEREKVERERELREMRLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LR97</accession>
    <name>A0A2X0LR97_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C013g07155 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C013g07155</name>
        <name evidence="25" type="ORF">BQ5605_C013G07155</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY14895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="565"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="812"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="869"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="823"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGY14895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1458" mass="159860" checksum="2BCADA4931DAEB67" modified="2018-09-12" version="1">MSPPSPSAAGDLDVQSDMATTPPPPSSINDVAPTTSVTLTQEQFDELIRNQRPARDDDAFSMRQLLPPANPPVFPDDSKLTEDNYVDWDLTMSVTFAREVCAYLRKGTHDPSWPLALRSRWEDYAARALAGSLTVTTKATIGPIVQTGGSAHQCWLALAARYAPSDAQAYSALIKDYFSMPPCPPTWAGFNAWTNRAMVLVNHLRMAQLDLEQAIAARALDDLPHVFDGWRTTFYAMNIRDNRLPRVEQIFASMETVARTLRNESNPALVAKAVAPTTSAAPGKKGKWDRSGPALSNCPACGQGKHWLDKCPDSGKRAKYVELRNAMKALQGASSSTTTALVAAAEASKDQDMSFFSSATFVNVGQPDILLLDSASACHVVNNASFFDGPLSPTQQVLQGLGGTLRASGIGLIKLVSDTGTTFTLNDVIYAPKSPANLILVRAFDRKGVRITFERGHVELRTPQGCFATASAIASCVYKLNASVRTGSKGALPSLVSTKSTRLPLLTLHRHYGHASVQTLKKLAASGQVEGLDWPYSDFEGVDFSCNACLASKAHRLPFPSSSSHAAEPLALVHSDVLSFPEESLSHKRYLVAFIDDFSRKTWVYPIGHKSKVFQTFKDWLLEIKNATGCRVKTLCSDNGGEYVSTAFNGYCVARGIRRELTIPYTPEQNGWAERANRSIVEGTLSLLSHSGLPRSCWDEAAMCYIHVKNLSPHAALGGDVPDRRWLGHTPGVRGLRAFSCCAWTTVPAHRRDKLNPKGIPLVFVGYDRHAKAYRLLDPSSMRVRLGRNVTFVETEFPFAIVPTRVTQPSIPGYSPLLPPPASTSSAVNDNTSSTTSTTMESAVNLPQPPPDPAPLAKVKPGWEYSDVTKVGPDPGKYGEIDTRNIIDGPRTRRQPVPTMITREQTVKDPNRPSASFKSLLLAFSSTKAGFADHDLSVVCDPANWGDVIRSGQEDVWGAPVRVEDEFDSLLNDYGVFQIVESGELPAGEILLRSGWVFWTKRNQHGDITDHKARLVAHGCAQHPGLDFEKTYAPVVKFTSIRALIALAAANGYHVHQANINKAYLHGKLDKPLYMRVPQGINLPGKILKLSKSIYGLRQAGTIWNAEIDSTLRSLGYVPTRSDICIYRRKHNGHLHYIALYVDNLLLVGPSTAEIDRVLDALELAYGIKRLGPAKYILGIQVKRGQDGSITLSQERYLRDILARFQFTNAKPASIPMQPCVVLDFEDLAATPQDCTRYLQAIGSLMYTAVGTRPDLAFVVSYLARFSQQPGPEHWTAIKQVLRYIKGTLGLGLTYRKTSQPLHGYSDANWGACLTTSRLTMGYAFIYSGGAIAWCSKREHRVAKSTTDAEYLSLSYTSGDAIHLSELLAELGHPVPGPVVIYGDNQGSLALAQHPTNHQGSRHVRISEHYVRERVAEKEIDIVYIATADMFADIFTKALGPKLFLFHRENLGLRVAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LRE4</accession>
    <name>A0A2X0LRE4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C013g07205 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C013g07205</name>
        <name evidence="2" type="ORF">BQ5605_C013G07205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LRE4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY15008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="95" mass="10593" checksum="CA235543B4204572" modified="2018-09-12" version="1">MIINNFSQTLYLARRPGLPWAPLRSRARSEAGDDPSQDQRRAVPKSATVVHTCNEWEGGGNSRWLMIHYCRLPPPTASVLRRCASRFRPSGGGAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LRS5</accession>
    <name>A0A2X0LRS5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C013g07335 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C013g07335</name>
        <name evidence="2" type="ORF">BQ5605_C013G07335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LRS5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY15340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="491" mass="55110" checksum="BB7C6BA7A4BDFE82" modified="2018-09-12" version="1">MYQHTVVSAAPACGVHVPIRSHVQALCAPGSNRAQTPQAHVSIRDDLGPQTAVCTHCKARHWECERSKSTRHFSACCSQGKVRLPPPPQPNLEYRQLLEGSDSDAKAFRENARSYNNALSFTSLAALWDQTQVGTLGPPVFRVFGRLYHRLGALIPAVTQRPTFAQTWLIDPAEATDTRLGPDGADSRMQRSTLTKLESILRTGHRFVREFASAKARAGWDTAKEWILRLCLPPGRDRRTHNLPTSSTEMAMLICDSDTNMGDRGPQDRILQSSARSIRLRCLYGSHYYFLQGKMASTPTFLFADFAKLGCQSPETESRSTMVSNRARYLRVSVLMTEAKRRTKTATMRMKTARKGTKRMVMANDEGQVKGSRWRVSRSPLFAHYLPNATSTSQSRIAPNVPSWKPTPHHDPRHQRLDPEPNRDITQRYQDAMACVVKEEKPPLLITMTACNRPDLIARVFEAKSGNKRHAGCFGDECKINGFCFFAVLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LS90</accession>
    <name>A0A2X0LS90_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C012g06895 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C012g06895</name>
        <name evidence="2" type="ORF">BQ5605_C012G06895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LS90"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="686"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="686"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="701"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="716"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="776"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="792"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY16528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="804" mass="88715" checksum="80762EF257DD384E" modified="2018-09-12" version="1">MGHHPVIALSRVHRLLRQLGAALANLALDLGNLHLKQRKLSFQAAQAAQRKASRAQDSEDHDDDEEWEGSGRTTMMAKAAARKRSKSSRVVAKVTTTYSRRGAITMSRTTSQASSTSSAPASFAAGTKAGLKRTRRSTGSGGGVSILLDARNRLSRLDGWEHDLVNKALHLIKTYSNVLEAVADANDEEQEENPTRTRRVPSLVEMMAREIGWNIEANVRSCREEEQSDSSEEDGVALRRKGALDEGDDEATLVDDWYDACPDYCRPWILIEHATSIMLEGLENPPFTLLEILFELCSRMGAGSASPRFYDALNYQALRMTDPTSSAHVLAQQTVLHGHSSTYFESLRTILFESTFADRLFYSPFLSLERATLRSGNASDAEALGGMIELVCGVAREMMGAIDLAILNGERDGERQKSDVIDRVAFEIGPATGFLFLAQDDEMVSITTSEGTFDGQRLARDKALERVFDAVLDLMHGTGPSPSKSKWTMQRLGPFVIAACSELALRSLDHHLSAQTGSSDVARLTECDSLIAHHILGLVEEEGQDLDLDQLTSELLPLAKQHSSQSFAALATLLRSADLSTLEKLVVYTATKAYDSLVDVRSTRGLIILEKDIFERRLDELNRPSSTSADRQALTTPPRRLARVLQLSSSDEDFQDSTPGLACSSLGMSSRKRFVPIRLVGTPLKEKAQEGRRAVDSRRCESKRKKDQIVRKRRRVMEESENSGHDDEDGPNLRKQSPTSERSDELDLLQAKSPKTRRPVVKKGAVLSVRKCGPGRSKRTSAMKRKAYAGPVDDEDTSEDELAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LSC4</accession>
    <name>A0A2X0LSC4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C012g06798 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C012g06798</name>
        <name evidence="6" type="ORF">BQ5605_C012G06798</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IF-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LSC4"/>
    <dbReference type="STRING" id="796604.A0A2X0LSC4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070124">
        <property type="term" value="P:mitochondrial translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.10">
        <property type="entry name" value="Translation initiation factor 3 (IF-3), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036788">
        <property type="entry name" value="T_IF-3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001288">
        <property type="entry name" value="Translation_initiation_fac_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019815">
        <property type="entry name" value="Translation_initiation_fac_3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938:SF0">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00707">
        <property type="entry name" value="IF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55200">
        <property type="entry name" value="Translation initiation factor IF3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor 3 C-terminal" evidence="5">
        <location>
            <begin position="164"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="126"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY16191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="247" mass="27413" checksum="61BC89B87BE72210" modified="2018-09-12" version="1">MAFNPLSVFARQLTALRSRCPSCSVALLRGSTSSSSSMLLRPHGSVSTYATSNAPKRPLQKSTQIKDEDIPLREIILVDPETNTLLPPAPLRTILSQLDRTRYSILLVDTDKGICKILDKKKEYDKKKDKAQAIKDKNEQARNNASHSSSGGGGASVATGSPPKEIQMTWGVSAHDLEHKLKKGRQFLEKGHRVTVIIKNKAGAPHVPKEAQDTVIRNVEERFAEVGKLSRDPIYRGTWVYLEFTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LSM6</accession>
    <name>A0A2X0LSM6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C012g07035 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C012g07035</name>
        <name evidence="10" type="ORF">BQ5605_C012G07035</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LSM6"/>
    <dbReference type="STRING" id="796604.A0A2X0LSM6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF4">
        <property type="entry name" value="SECRETORY 24CD, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="6">
        <location>
            <begin position="422"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="7">
        <location>
            <begin position="508"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="9">
        <location>
            <begin position="755"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="8">
        <location>
            <begin position="850"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="5">
        <location>
            <begin position="978"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY16937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1125" mass="123120" checksum="1312793D2C6109D2" modified="2018-09-12" version="1">MDPRAAASMPPPPHGAHDGYANGAPPSRSPMAPPPPPPLQPPTGFAGPGAPSPMGSHPPHPHPHPQQQQQQQQQQQQHFARSPVAAPRQPPQPPVGYPISNGHGAAPAAAAPRADPALAHQMSRVDLNPPSQPQHQQPQQQQQPLAQQQHQPQKQSSLPLSAPPTAPAEGPALAKAKRSARAYHRPEQAPPGPSGVQQQQQYGDQPLPPHQQQEPRYDDHRGPPTGPSGPAYGNSSRPPFAGHPSSQHPSQHPPHLGQGAPAGYDQHQQHPPLPQAPYQNAPPASGPIQLSGRGGYPTEQPGIPQPPHSAGQRIPGQMRVRIDPDHIPSPVDVQRIDQQLYQDEPYLTCSRTAAPLSTTEFVAIDQGNCNPRFMRMTTYNLPATDDLATASHLPLGLVVQPFAMLREEEGGVPLIQSGESGPARCQRCRGYINPWCLFIEGGQKFVCNLCGATSDVAPEYFSHLDMSQRRMDLDQRPELRMGSVDFLVDKAYWVQDNPSQPGKSAREPKPINYIFAIDVSWTSMRCGLVGEVVKGLREMLYPQEEGAVSCLAPGAKIAIMTFDRSVQFFNLKAGLDQAQMLVVSDITDMFVPLLEGFLVDPFESRSVIEGLLDTLPTLTAETTVVEAAMSGPVTAAVMALRNLGGQLNIFQTSLPTTGMGALKHREDTKLYGTDKEKTMFVPQDPWYRATAEECVEAGIGVNMFLFPTQYIDVASLSVLSGLSGGEVFFHPRFAPVRDGTKLRAEIKQVVRRETGYSVTMRIRCSNGLRVSDHFGNFFQRNVTDLEFGTMDSDKAIAARLKHEGKLDDKVDAYFQCAVLYTAANGQRRVRVHNLAVPVTSLLANVFRFADIDTTLTYVTKEAVTQTATKSLREVRDQLTELCVKSLLAYRKHCASSTSPAQLILPESFKLLPLYALALMKTKALKGGPVASDVRTCSMRAVKSLGVNSTLRLLYPRFLAIHNLPDEVGFPDERGRLRLPPLIRTSYARMEPHGVYLIENGDFVILWIGAAVSPQILQDLYGADSLEELDTRMTSLPVLPTLLSTQVRNILALFERQAGGKVFSVLIARQNIDGTEIEFSNMLVEDSNNEQLSYSESLCHIHSLIQSDLMGESKKSDFDVSSFSTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LSR5</accession>
    <name>A0A2X0LSR5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">orotate phosphoribosyltransferase</fullName>
            <ecNumber evidence="5">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C011g06561</name>
        <name evidence="11" type="ORF">BQ5605_C011G06561</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="5"/>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LSR5"/>
    <dbReference type="STRING" id="796604.A0A2X0LSR5"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046132">
        <property type="term" value="P:pyrimidine ribonucleoside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46683">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46683:SF1">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="10">
        <location>
            <begin position="88"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY12627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="240" mass="25574" checksum="2DA0F6713CD89241" modified="2018-09-12" version="1">MATDNTSSSSPYAATLISASFTSGQPILRFGSFTLKSGRQSPYFFNFGLFNTGALLLSLSGAFADAIIAAFPSIGLTPAAPAASGSLDNNTPQVLFGPAYKGIPLVAAISTELARRGRDIGYSYNRKEAKTHGEGGSIVGADLRGKRVLIIDDVITAGTAIRQAHQIVVAEQGHTVGIFEALDREERGAGFLSTVQEIEQELGLPVFSVVKMRDIVAWLDGQNRDPEKLAMEAYRQEYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LUD7</accession>
    <name>A0A2X0LUD7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C017g08327 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C017g08327</name>
        <name evidence="2" type="ORF">BQ5605_C017G08327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY19814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LUD7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY19814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="164" mass="18036" checksum="0B9699D1071DDB09" modified="2018-09-12" version="1">MQISGSCSNFVFFGAFRTFVGAEYAPNGSRSALKGVLGPRSTYLSRSVYQVRAFPILRLDPAARPEETSRSLSAASSPKSSTASHDDPAERDPPLPPDDGHEYRPYRVGRTPSLLENINEGNTLPLIVLVFTRHQPLPKTFKDAMASPEAEFVSLDQRSPRTEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LVI0</accession>
    <name>A0A2X0LVI0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C012g06733 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C012g06733</name>
        <name evidence="2" type="ORF">BQ5605_C012G06733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LVI0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY16011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="332" mass="36635" checksum="2EF6E78A73ECB8D8" modified="2018-09-12" version="1">MPIKLLISVATSSCSTQGRPMESSDPTRGEAGVGVSNTEEGRTHSCVLKGLVQSMGPSRCEDMAGTTRSFRWTRGDQMDRALTTHEDPEEYGALAQRYPHFGSLDGGAVTTTTTSEIGSLVCFGLKRGMHSISCDQTAYGEEVLFIGTVRYIYSKVTTNHCNQNTLASLVLLSNVVVQELRLIKKTCYSTHLIDGTMPFRMIDGRQVIESLGPSTTTYRSTTDLTSCYPDERLISTSAHAEQRFAAFGACPACEMPPAEPLQAAQMPPRKQGSQLQQKGSLTTKQRASQQSKEGLFEAWSHAQHQPKRRAPRATFDRPPRARKRSERVFEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LXH1</accession>
    <name>A0A2X0LXH1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C015g07989 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C015g07989</name>
        <name evidence="2" type="ORF">BQ5605_C015G07989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY18148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LXH1"/>
    <dbReference type="STRING" id="796604.A0A2X0LXH1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY18148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="388" mass="43060" checksum="CF3A030951ACF5D4" modified="2018-09-12" version="1">MASTSKASIAQPPPPLLKPKSIIPNAPAVVPSFESLPVNKIQVEKALTALLAHLEKAKSKFLFDLLQDEQHKLSLVVGLKKVPSRPVHKPIRLSVSNPQDSFSTRSFELPPSSPLKHALINPKESPVTLFVKDPQRQYKDLLETSDINFISRVVGLDKLRNKHKTFEAKRALLKEAELFLVDDRVVIEVGKAIGKMFREANKQPVPTTITRKDLKAELERAVSATYVQVNTGTTFSIKFGSTGLHTPEQLLDNLLCVIPQLAVRLPFPNDGFDIIQTLHIKSTHSTALPIYNVSLDDQGRFKGPSQAEIEVVQAKKEEKERLALEKQKKELEKEKRRIERSATKTGKGRAGKRDADAVAAAAAVQEVEPVQAVEAEQPKKKKSKKSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LXM6</accession>
    <name>A0A2X0LXM6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C014g07434 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C014g07434</name>
        <name evidence="1" type="ORF">BQ5605_C014G07434</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY18669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LXM6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY18669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="210" mass="23937" checksum="3B5CA84D4D23695B" modified="2018-09-12" version="1">MEDVLPKLWHRRYNHLALEIQHPIHTREPWRRVEIALDLLAKGIGVIALHKAAPQLCVDVHLRNRLYGIRLPLRERVPAHCVCHGVLASRNRFVVRKDMEVDTHQVDSPLTQGVHDRQKLLFMGRVVDLRTDVLTRPICHRVCLAPILPLKQHGAYPNVTCVRHNPEGISGICVVDRLETWQQGDDGLYGVEVSLLLGTPHESDIGVLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LXT4</accession>
    <name>A0A2X0LXT4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C015g07907 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C015g07907</name>
        <name evidence="2" type="ORF">BQ5605_C015G07907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LXT4"/>
    <dbReference type="STRING" id="796604.A0A2X0LXT4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22903">
        <property type="entry name" value="NI9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039961">
        <property type="entry name" value="Nuo9.5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY17833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="85" mass="9778" checksum="EC07EA14A371DD91" modified="2018-09-12" version="1">MATLHGSILGPFRQSYRYLQRSAHEQPVIFYSIAIGLVGPLMVLVVPEVRRSWGWRPAERPPTTYPCKIRYSNRSRAYYPGKGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LY09</accession>
    <name>A0A2X0LY09_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C002g01206 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C002g01206</name>
        <name evidence="1" type="ORF">BQ5605_C002G01206</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY31060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LY09"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY31060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="50" mass="5674" checksum="3009AE91A5BDEF8D" modified="2018-09-12" version="1">MYQHTVVSGAPACGVHVLIRNHVQALWQLLYFSRQSNEAIAFSLFSVVFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LYM9</accession>
    <name>A0A2X0LYM9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C017g08416 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C017g08416</name>
        <name evidence="2" type="ORF">BQ5605_C017G08416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY19976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LYM9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY19976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="160" mass="17817" checksum="CD32899C6DD065E3" modified="2018-09-12" version="1">MLQMNNQSLYAGMAGVQMTSQAQFGVFSANQVLSDLRMQLFFHPKNSQEYYDIKEEIEVAKQAVKEAQLMYQQTLQQSNLAIQNANPIFHQQRLANNASTPTEANTTNNSPTRERDEPGGSPSKRGRLTHHARDADGEGSLVSSVMGTERRVEEGMSIDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZ01</accession>
    <name>A0A2X0LZ01_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C002g01536 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C002g01536</name>
        <name evidence="8" type="ORF">BQ5605_C002G01536</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY33741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LZ01"/>
    <dbReference type="STRING" id="796604.A0A2X0LZ01"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048211">
        <property type="term" value="P:Golgi vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006955">
        <property type="entry name" value="Uso1_p115_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024095">
        <property type="entry name" value="Vesicle_P115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006953">
        <property type="entry name" value="Vesicle_Uso1_P115_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013:SF0">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04871">
        <property type="entry name" value="Uso1_p115_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04869">
        <property type="entry name" value="Uso1_p115_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vesicle tethering protein Uso1/P115-like head" evidence="6">
        <location>
            <begin position="449"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="domain" description="Uso1/p115-like vesicle tethering protein C-terminal" evidence="7">
        <location>
            <begin position="1016"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="385"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="856"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="953"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1108"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="782"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="908"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="867"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="961"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="980"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="996"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1122"/>
            <end position="1133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY33741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1133" mass="123518" checksum="B20CDE5173EA855A" modified="2018-09-12" version="1">MFSTLARGYGALSAGATQQSPVETIDKLCDRLLNGTHLEDRRAALLGLKGLSRDWKSVRARELFVLEVGQRALPILLGVLEEDAPEDVEMAKAVVETFSLLCEVEEVDSRPVRDDSGLRNTDGFLQTAAPLHTLLTLLTPVHFYLRFFSLQLLGVLIANRSSQVQAHVLTAPGGVGRLVETLDDTREIIRNESLLLIIALTTSNADIQKLLAFEGAFDKLFAIVRQEGGIGSGGIVVQDCLAAIGGLLRWNVSNQNYFRETSCIPLLAPLLLFPLPMAQTPASLSAFALQSWSEQKVVNAGLVLSLVRMLVGGAGAGREANQKALLTSGMSRCLAEMALASNAPSMLKSQAMNALADILRLSPPNQAALNSLIVVPLIRPMASPPAEHYNPHYDDGEQAQQRGGGSQSDDEDEDEVDRRSNRSKWRKGTPAPAVIAVVRLAVVGDGTPGRSGLRVRAAAANLFQSYVANSTETQLGILSTMVAPSPDTDPSGPQIPSAGSILLHAMRTFPSATRDHFDSYVPFFACLLFSHLIMGSETSKEFARKIYFTGDDAEPGGYGDEEERASLVSILVGNLMMAQREQVQSANAGLGPDRGLEWSRIMVGYLMVLSLWLWDSPTTVTEFLSEGSNLQVKTNALSIADGVLQLIQPITQSSGVDSVVQGLCAFLLGICYEYNREPGPITRETLHPILHSRVGADQFVSRILRLREDERFRSVGPAVLELIDEEMEEELGEEQGLWFDYSFVEFLKTNYISVQRAILMDPTANTTSRRSLDGNGDSYEVVTALRSSIAAQTEQMEDMRNQILGLAAERDEEVSSSSGLVDSQRIAFQNEIESLTARISGLQAELEQAYAEVNAARTGGGGGSNNNRDDPYTPRGGDDPYAPRGDDPYAPSLPAAAAVTSPLDPVVDHEASKKIEILEQEIATLRTELDTAHSEHQRVLSELELARHSRTVDDLFGGGQPTSQGANETSSFQSGIDFFNSSSTQTISSNDSPFGSHPPAPPPTHDPMELERLRAELERTQKLLESTNSQLETSRQHLASTRTELDQLRDATPLDVDTIRAGRSDDALAEEVSTLRRELEQAQSAKEEADKEQEDLLVLLEDVSSKRKMDKQRMRSAFMQVSDDEDDDEDDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M0Z5</accession>
    <name>A0A2X0M0Z5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C008g05238 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">BQ5605_C129g13355 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C129g13355</name>
        <name evidence="4" type="synonym">BQ5605_C008g05238</name>
        <name evidence="4" type="ORF">BQ5605_C008G05238</name>
        <name evidence="3" type="ORF">BQ5605_C129G13355</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000021">
        <property type="protein sequence ID" value="SGY27382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M0Z5"/>
    <dbReference type="STRING" id="796604.A0A2X0M0Z5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051380">
        <property type="entry name" value="pH-response_reg_palI/RIM9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013:SF4">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="507"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY27382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY79862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="537" mass="57602" checksum="E25DCEC65396D46B" modified="2018-09-12" version="1">MSCIRPATPGTVVVLAGTVLLALVSVSVPILKPFYFLKAEVASNEIILGVWGYCSGSNCTQPKLGYALDLAHVFGYSGVDGIALTESIPNALVKGLTYVLVLHPVAAVFGATSVLLGLLAHIRGFGGTCWTTFFASLGASTALLAFAIDMALFLIAKKRITSSSVGGAASLGAALWMTLAGGLLLMVSGCFFGCGGRMVTDRASRREDSEKNRPGPDPAYSEHMRNSAYQQQQYNTWNGGNNLPTFAEFHNSEAIPLNQMGEKNDFDDDVNDAGYVGRAPYRSGGAAVAGVGQGYGRRNDGPVLTGGGPTSPQRYNSPSAYPPPPRRTTTASPPPAPYGGTTEPFQSMSASNGKLTKPLRPPSPPTPQEHFHPSQAYAAFVALPPSTVVTGTPEPSSPTGGNNFHGSRDIAYQPMSSASPAPSQDQYGGYHHQATHQPTYRGNNDLAQVARQHTGPAPSYNTYQPDYAQHMPTHQEHQHYDSQPQHQGYDTNAPQHQYNYDAPVQHGYDSTPQQQQQSYQYGGPQYDQYQPHQQTRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M1H1</accession>
    <name>A0A2X0M1H1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="4">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C003g02375</name>
        <name evidence="13" type="ORF">BQ5605_C003G02375</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="4"/>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY40433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M1H1"/>
    <dbReference type="STRING" id="796604.A0A2X0M1H1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02659">
        <property type="entry name" value="peptidase_C19C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000011">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000005">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024729">
        <property type="entry name" value="USP7_ICP0-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029346">
        <property type="entry name" value="USP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF644">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14533">
        <property type="entry name" value="USP7_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12436">
        <property type="entry name" value="USP7_ICP0_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MATH" evidence="11">
        <location>
            <begin position="137"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="12">
        <location>
            <begin position="294"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1177"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1177"/>
            <end position="1188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGY40433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1196" mass="135847" checksum="5382433C8448546C" modified="2018-09-12" version="1">MVKHGGGGGGGGGGGGNGGGNGGGNATPTANLTANPAAHAQPAPPQQPAAGVLVPADESQAQTGGGRGSVSPSSGTAGPPTVAPMDIDIVSVDDPYHIRPCSVTPQGPVLNPPSTAPTDEGFANKHLTDMGEEVHDFKVFTWKLSDYRRADKRLLSPEFSCGGHKWNVLLFPMGNSNGQANDMVSVYLNYGDQKASEGWHVCAQFALAISNPSDPTVYIQSQAHHRFTQEEQDWGFTRFVELRKLFSVSEGRPKPIIENDETIITAFVRVLKDPTGVLWHNFHNYDSKKQTGHVGLKNQGATCYMNSLLQSLFLTNSFRKAVYQIPTEDDTTDTVPLALQRVFYNLQTSDQSVGTTELTRSFGWKGFDSFLQHDVQEFNRVLCDKLETKMKGTAADGEIKRLFSGSMKSYIKCIDIDFESARTEDFYDIQLNVKDMPNLEASFEDYIAMETLEGENKYNAEGFGLQDAKKGVIFESFPPVLHLQLKRFEYDMQRDQNVKINDRHEFPLEIDLEPYLSEQADRSESYNYKLHGVLVHSGDVHGGHYFVLIKPSADGRWLRFDDDRVVPVTDREVLEDNFGGEPLLNNGAHPPNAKPAMKRFTNAYMLVYIRESRVKEVLDPITVEQVPEHLRLRLERERRDAEMRKKERDEQHMYLTVKLVTDETFSKHQGFDLATFDDRTVAATELPTYRVLKTKPYVVFRAEIAHQYGYNPEDIRLWVLVNRQNKTVRPDAPISDGDPTLTMEVVREKMASRQQDFKLYLEYISKEEKAEWQKNHQNEPPIMIFVKNFDVAHQTLAGLGHFHVHRHMRVLDLAQMINDRMGFPPSTPLKIYEEIKPNMIELMKMKATFLQSEIQDGDIVCFQVDMTERDSLPQDLDKQNMFTTPIQFYDFFLNRVVVTFRPKYEDANAREEFEITLSKKNNYDQMAGRVGERLKHDPLKLRFTQANGQNGQPKTIVRRQGSMTVAELVSPSYNMTHAANLLYYEMLDVSIIELETKKSLRISWVGPTNKEESSHGFLLPKNTTIHDCAQDWLRKDVRMQNGGSGEIRIFDIIKGTIQRIYTGSELVRDVSDQTELFAEEVPLEEARADDGSRVVPCFHYNKDPSRTHGIPFRFVLKPHEAFGDTRKRLQARLGLGDKEFAKIKFTMLQNAMYHKPMPLNDSDVLFDHKWQDDDFIGLDHPDRRRPPAERGVQING</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M358</accession>
    <name>A0A2X0M358_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C001g00360 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C001g00360</name>
        <name evidence="1" type="ORF">BQ5605_C001G00360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY45925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M358"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY45925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="186" mass="20482" checksum="F252F95EFFC82215" modified="2018-09-12" version="1">MPSANHDKLQSAILSAGHKGQGHRVFARDKIYWPPGTLPVPGGKQLEYVVGTERLCYYEVIDASVPSCHYIDAEFTRPSIDNSAEKALITRNAASYFPGTYGQNCRTTLFPASVLYLLFQRQRIISAFILTAGTPFGEPNAKRVITDILDSLKVLLSLRWRLGGSEGVVGEIWVLCCCHPQALGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M3C0</accession>
    <name>A0A2X0M3C0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C002g01762 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C002g01762</name>
        <name evidence="1" type="ORF">BQ5605_C002G01762</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY35397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M3C0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY35397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="120" mass="12933" checksum="EDD4C748EE5CD99F" modified="2018-09-12" version="1">MFDHALSTYCSGTINFAPPPSMDLFRAGEEACSKRNPTVERNLVHRRVDILGVGGRHGRGSDGLWGVCCGGQNWRGFIAGEAHKMSKYGEGVHSLGLDDGLGLGLDQARSIIMHHHDSAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M3Z8</accession>
    <name>A0A2X0M3Z8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C003g01843 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C003g01843</name>
        <name evidence="3" type="ORF">BQ5605_C003G01843</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY37608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M3Z8"/>
    <dbReference type="STRING" id="796604.A0A2X0M3Z8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040151">
        <property type="entry name" value="Gfd2/YDR514C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048519">
        <property type="entry name" value="Gfd2/YDR514C-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083:SF1">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21762">
        <property type="entry name" value="DEDDh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfd2/YDR514C-like C-terminal" evidence="2">
        <location>
            <begin position="228"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY37608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="533" mass="57788" checksum="3E7ED0BF0A5B344A" modified="2018-09-12" version="1">MSRSMYDDEDTDCPPMNKGPYVPVTFCKSPPPLLTKYRSTSLTKEYPTLHSFLASTCTPGGLLRLLATPSGLAVIVASRDGPNGVGELWFNVEQTNLIRLGLRRALIEGGVTSPEAREIEGDNWEDKGSEAVYQADTLTLVPFSTSNTTSSSTTGSNSTPEEGQLETTSRLAASGGFGQAVFTSQAALDRALKSIKKQLDRVGSNKALDGFSKMKDAWAIAKKHKARVVALDVETWEHNHDVITEVGVTLVEAQSGRRDSRHYIIEENQKRRNGRWVKDRRDYFSFGDSQTLPERSISIILQRLLLPFPAPAYPILLILHAPSADLDALAALDVDVLLFHKTLEPLLRPRLSSTPGTFILDTQALYRGWSKANSQPNVQQVGQEPKLISLGDAVKRVGLEPGESLHNAGNDAYYTWKVFESMMNKDDVVRMPGGSRSGVGVGQGQMANDHVRNGQGHGTGNNGRGRGKATPTPSPTQPTHRIPGLHAPAPKAPVRPAPNAEGWGAQPVVKAPPRRSNGGWNVPDGSESVGQGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M5Q7</accession>
    <name>A0A2X0M5Q7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00069 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00069</name>
        <name evidence="2" type="ORF">BQ5605_C001G00069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY43839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M5Q7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY43839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="636" mass="71302" checksum="584911EC210D3ED2" modified="2018-09-12" version="1">MGHVVFDRYAESSVRQRWYIQFVGGDGPGISKVLGFKGPNSKWPCRVCTIKGITGPKGRKNYYPMKNVTGVPPDPDRPDLQVDDLPMRSEESIRKIAWEVTTGRARLFKDPDMGMNGLARIAFIPGFGFHKDGALDFMHAAFENIAKRLVNLWHPSKEDTAARVAQGLEPDPWVIGDNVWEEIGLEMKACAAKTPYQFLRAMPNIARTQSQMTAEDWSRSCSLALAFSVVVSRPFTSSTSNISQVGSARAWRWRSRKPMSCPEASSGARSTSGTWNLKALSELLKVLYDRVYYNGRPAHLKIFPYFLSCRPAHCGFYFRYNQHVKRLTSTRQLPYSAIMRGIMVDNAMKSIAARYPAVFYPASKRKVPSGNKLEQPGPQVEQSLGDGQAEPEAMEGCELVGAKTIQQEKLSVNVKKLLITYINCTCALEPVERTVCTKILSEGLLIRKLLPKELMVAYTAILNGSRIVGSSQPSPRGPSRREAFAVRTTRRDCSWISYTLFVDEDARRSRNRSRPFVGVEHKFYGEALEFYRFNLAHPVHGETEHTVVVVRQADGLVAVGPENAQHFHNLYRYKKQGPLEAVPVQQVLTVAGRLHRKLDSSFTTGADVGPANVWYFCFDRPIGIAQAVFDDSDDSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M5U1</accession>
    <name>A0A2X0M5U1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g04056 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g04056</name>
        <name evidence="2" type="ORF">BQ5605_C006G04056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY55653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M5U1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY55653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="123" mass="13527" checksum="D3245DEBE59D4258" modified="2018-09-12" version="1">MVAELGCPTLVVRRDCPRSSQDGNHPSRIPRPSRLRPKAILKISAFFAMVLLLTAVLVGHADLLGYLATQTIVITQRASIPGRSSLFVRDALSKQRYAMSGLRLLSRRQQAIARMTGRDAGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M6N5</accession>
    <name>A0A2X0M6N5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00097 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00097</name>
        <name evidence="2" type="ORF">BQ5605_C001G00097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY43981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M6N5"/>
    <dbReference type="STRING" id="796604.A0A2X0M6N5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY43981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="333" mass="37310" checksum="B461B2B0D9CDB07E" modified="2018-09-12" version="1">MAVCINYKARHWEYKRSKSTGHYSTCCSQGKVQLPPLSGPIPNIEIYLKDSGHIPRKRPVAQQRAVFHFDQTRIGTLGLPVFRVFGRLYHRLGALIPAVNQRPAFAQTWLIDPAETTDTLLGPDSPDSRIQRSTLTKLEFKLWVLRLCLPPGRDRRTHNLPTSSTEMAMLICDSDTNTGDRGPQDLILQVHGDRCPDGRPKYQVVSSLHPSAMPLRYPLLFPAGEDGFHPNIPLCGSIELGHSSPKDRNKEGEDEEEGDEENGDAQTDIECLNTYDEGQVKGVKVVSLAFTNPLRSTCTNATSPHGTQRPFPAFVIERYSQAETDRLNYIQLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M7B7</accession>
    <name>A0A2X0M7B7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C001g00367 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C001g00367</name>
        <name evidence="3" type="ORF">BQ5605_C001G00367</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY45982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M7B7"/>
    <dbReference type="STRING" id="796604.A0A2X0M7B7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025183">
        <property type="entry name" value="DUF4110"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052588">
        <property type="entry name" value="Kelch_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063:SF1">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13422">
        <property type="entry name" value="DUF4110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4110" evidence="2">
        <location>
            <begin position="617"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="714"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="714"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY45982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="736" mass="83088" checksum="7C3DDE9D3FED7024" modified="2018-09-12" version="1">MGKVKKRTKDKSVKDTKAEAKKAKKDKQSKKEEAKLKKSKGKNKDDGDMDEDDLIRTLEEYRERWAAEHTVSEDVVDGPPSRRANATLTACPVKDHLYLIGGEYFDGSTVAIYPDVFRYSPDKNEWRRFTSPTAPGPRSAHQVCASPAGGGKLWLFGGEFSAPNQSSFHHYRDLWCFDISTHTWERYDTKLRPSARSGHRMAMWKHLMFLFGGFQDTGIRTSYLGDLWVWDTLNCRWHQIEIGQVDRKPGPRSGFSFIPCPEGVILHGGYTKTYEGKRATGQALNDTWLLRMPPPNEHGEYDWKALKWEKRKKVGYAPTPRSGCTMALWSPKNMGVLFGGVSDEDKDEETLDSTFYSALFGYNMGGNGRWISLPLKRKKKAGGKKKKAKLLQQQQTPKVSIPSSPAANDDGEGHDEGDDERMEEDDQSDNEDDTLKPWEVAEQKKQEALNDMDDEDDTDDPEKTIPGARYNAMLAVQRNTLYLYGGILEAGDKEYTLDDFFTLQLDKLDRFNCLRECILEGLDWKGSDSENDSSDDDEDDDGAGSDKSDNETEDEEDDGIAPAGEDANMEAVPLEDLQLSEVNLARIAAQKEQAEREELRKRALAFRGVSTSADRTAEDLISTPQPGETLAKFFARSKEYWTRKAHESVGAGNRGKELRRDGFSLCEEAFRKPSFPESHTTRLYRTDPFDGFFVLAEQYQPLLEELQRIQEQAGLDAAEAAKGARAGLGMDSRNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M8D4</accession>
    <name>A0A2X0M8D4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C004g02613 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C004g02613</name>
        <name evidence="2" type="ORF">BQ5605_C004G02613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY66022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M8D4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY66022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="141" mass="15373" checksum="1AA40A257C465F9D" modified="2018-09-12" version="1">MVAELRDDIDGRGERRGANSEANVERDNSQRAGEVVCFVELGITTLREKRLLSLVDVFPVAMHIRGSCQRFDVDGPRTLSLIGVERLRQLVSIIPNTMRSPPTAGELAQGAGPAVTAPNTYAKSVFPPSTATPLHRVDAWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M8L8</accession>
    <name>A0A2X0M8L8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C006g03975 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C006g03975</name>
        <name evidence="9" type="ORF">BQ5605_C006G03975</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY55142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M8L8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF28">
        <property type="entry name" value="TRANSPOSON-ENCODED PROTEIN WITH RIBONUCLEASE H-LIKE AND RETROVIRUS ZINC FINGER-LIKE DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="8">
        <location>
            <begin position="134"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1063"/>
            <end position="1089"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY55142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1089" mass="120549" checksum="55FB05FD99359B22" modified="2018-09-12" version="1">MYVPDERVIQPWREDNGWCASPGFTKQTRASNQITESRLPANPHSQHANCLYLLDADHAKCQQLAFLSRSESTVPLLTLHHCLGHLAPSSVQKMIAAGLLDGFGAGYSDKDVEEFVCNACLGSKGHHLLFPDSESHSPERLGLVHSDVLSFPTPSLTGKRYLVTFLDDHSRKLWAYAIDHKSDVFPTFQTWLADVELETNARLRVLQTDNGGEYRSNTFTEFCKSKGICRQYSFPYTPQQNGRAECVNLSIVEGVLALLADARLPATFWDEAAAYFVYCKNRCSHSALAKQTPEFVWNGQVTTTTALHPFGCTAWLTVAPDLRSKLDPKAARVIFTGYDLASKAFRFFDHSINKIVLGCNATFFDDDFPGLPVTTPVDADDTDRQFVIPVDTPAPAVKTRTPLVRSAHMDVSSSLDDSAMSAVDVAPGYTGGSLLNSTGTRSSSSPSLSPFSLPATSSAREASLNDLDDPLDLLSSNTAVHLNLMDVHRSDDDTLETQAPAVDPVEQPSDDDSPNEINFLSRHHRAFIATESDDPTLEAIEPVKSITSDPQTWREAMSSDERDIWAQAAAAEFTAMRDDFKVFTSEPRSTLPPGATIVTSKFVWKTKRDARGDVTGRKARLVAQGNRQRDGIDFSETFAPVARFSSIRCLLALAAANGYHVHQADIDKAYLHGELDHDIWMTTPRGFDFPSDKVLRLRRSIYGLKQAGRIWNRHIDTSLRNLGYKATGTDHCIYSRIDDQQRPHYIALYVDDLLIVSPGLDEIERVISGLQQRYGVKRLGPAEYILGIQIRRLDDGSIALSQERYIMDVLARFHFDTTTRGTTVPMTPGLSLTAIPGQGTERIRSWYLQAIGSLLYISLGTRPDIAFAVSYLSRFANNPGRRHWIAVKHVLRYLRATYRDELLYARGPAKVTGVVGYSDANWGACVDTSISTMGYVFYLAGAAVSWSSKRQTRVADSTTDAEYLALSHAGKEAIYLTQLLSELHVSPIAAAHIFTDNEAAAAVAHDPVRTSGTRHIRLREHFVRDMVNWGDISLSHRLGPKIFGTHCYALGLRTRHPRLKSTLRSRGGGCEESTLRSAQDLGARSEPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M8Z5</accession>
    <name>A0A2X0M8Z5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g03803 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g03803</name>
        <name evidence="1" type="ORF">BQ5605_C006G03803</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY53805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M8Z5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY53805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="113" mass="13057" checksum="EDCD71A12132B6E4" modified="2018-09-12" version="1">MNFLQAFNLMLTRQWHEMWSLYHEPSDPTDIGIKVSSLPPKGTLEEGQGVWKMEDASAFFHECEICSWRKPQWGTFMLMASLTHKVVPQWSSEILALSITDVVYSWGYDSGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M9C3</accession>
    <name>A0A2X0M9C3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C004g02943 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C004g02943</name>
        <name evidence="10" type="ORF">BQ5605_C004G02943</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CND3 (condensin subunit 3) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY69030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M9C3"/>
    <dbReference type="STRING" id="796604.A0A2X0M9C3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027165">
        <property type="entry name" value="CND3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025977">
        <property type="entry name" value="Cnd3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418:SF5">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12719">
        <property type="entry name" value="Cnd3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear condensin complex subunit 3 C-terminal" evidence="9">
        <location>
            <begin position="597"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="509"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="942"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="510"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="944"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="969"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="981"/>
            <end position="993"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY69030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="993" mass="110924" checksum="883ED93A99598816" modified="2018-09-12" version="1">MPGPKAAPSTSKLDSLETVQQTLQQQVPQLFGASQHSVASHRKNINTLHGLFLRAAQVTTLSNDGTTLRLTGEKAFGDAFRAAVVHPLGVKKGVEQADRIIKYIAGFVGFAVEHDFKQREAEAGEQDDDEDEDGPASRLVAQLLAFLLKGFQAKNKVARFRSVQLVALMVNSLGEIDDDTYQLLKQALLERVRDKESTVRMQAVVALAKLQEADEVDEDDDDELSVSDVLIDVLTHDPAAEVRRAALFNLIPSPKTLPALLMRTLDVDPINRRAAYLHVLYEIPCARLTQTQREDAIARGLRDREEGVRRAAKKLVSKWAEDAGGVVRFLEFFDLYEGKAAENILSAIFDSNPALMEGLDFGGDFWQILTPHTAFTTRVYLNHLRQLEDPRLADLEPVVTALAFFVQNEWTKLVVSLDAAERDEGAELELEFVVGELVEMAIDLDYGDEIGRRKIFELMREMMSNSILPYSLVPKCLDVLLKVTSSEKEFMRIVVEIVQSLRADSHLMTTDDDADLDNDSEDEDEDEGVEARKARRKRRYTASQEPVIFARRKQLDLRCLVIVKALLERVMGVSLYQQVSARGEGGGADFFGGLIDMEQALQENSMLHGLVTELVVPAIKQKDQEVRSSGLVCLGLISLLDKPTAVDSFELLARQSQDTEGELRVKILQTLFDLLVLHGINLGADRGFGADVILGFLMSSLEQEEPEAEATCVIGVCKLMLSNLVTDEVILSRLVLLYFASETIDNQKLRQCLSYFFPVYAYSNPANQRRVSKVFLPTLALLKDVYDELGTTERNAMVAPLQIGLQLLDWTDPQKSILAAEDTKASRAQLDETIHLDLSVQMIKALFQQTLKDERKLLCQLLPKLYIPLEAPGLKVKALLWLIKATKSKRALSDTVSKNALERFEKMVVKTCEEQVNEVDEEAWQASAEFADVRDFVKTNLEGVQDEEASQEDEAESAAEQSEEEEEAVALPVRRAPAPQADDEDEEEEEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M9G8</accession>
    <name>A0A2X0M9G8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g04275 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g04275</name>
        <name evidence="2" type="ORF">BQ5605_C006G04275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY57467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M9G8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY57467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="52" mass="5807" checksum="96832A9853D123B3" modified="2018-09-12" version="1">MSRKAAERRGVKPEAEGHVSSCFDGKWNLNERWNLGERGRNGLSPRGLSPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MA75</accession>
    <name>A0A2X0MA75_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g04133 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g04133</name>
        <name evidence="1" type="ORF">BQ5605_C006G04133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY56419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MA75"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY56419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="60" mass="6541" checksum="6ECA2001EA7C13D0" modified="2018-09-12" version="1">MPSPEAAARNRSRRRRANCVGQCANSAVRGPASVSRACRHWASLHDISRSSATFYEPGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MB47</accession>
    <name>A0A2X0MB47_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C007g04425 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C007g04425</name>
        <name evidence="5" type="ORF">BQ5605_C007G04425</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY60397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MB47"/>
    <dbReference type="STRING" id="796604.A0A2X0MB47"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22272">
        <property type="entry name" value="DPBB_EXLX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.760">
        <property type="entry name" value="Expansin, cellulose-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036749">
        <property type="entry name" value="Expansin_CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049818">
        <property type="entry name" value="Expansin_EXLX1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041144">
        <property type="entry name" value="expansin_EXLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF21">
        <property type="entry name" value="EXPANSIN-LIKE PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015905654" evidence="3">
        <location>
            <begin position="25"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="RlpA-like protein double-psi beta-barrel" evidence="4">
        <location>
            <begin position="256"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="55"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY60397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="429" mass="47325" checksum="DD8BCB1C622A6ADA" modified="2018-09-12" version="1">MRSLTFYLSASTALSLLSAPLIFARHPISQLDSHATRPTLVKHVMNEGMLLRRAPVRSHSCRGRKRHDRRVSPGHDDKHEHRCDPHPKRKHKETDHKHRHNGDKAKHRNDHRHRHHVSQNRDPYASSTLSSQHSDTHTHKKHDQKHGKVHASVPDPTTGSGDKGKSGTQDPQSKQPQQPVGSTQKDSPPATRQPTPALLKAGKAGVITTFKGTMQGPATFYAAADDGRGNCLLPIREDNMFAAINDFAWAGSAQCGMCVRVETLDGNKSTTVMITNREPERVEGAIDLSEEAFTALAREEVGRLAVNWTPVDCVKAGLVTSQSPSVVWKNGSTEYWFGLQVRESALPLAQVSIRITSPGNTTSTPLDPGFSPWSLLNRTDYNFWLASSGIEDGKGGKSVGPFDIKVQYQDESEILFPAIKLNSEVLKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MB93</accession>
    <name>A0A2X0MB93_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C005g03562 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C005g03562</name>
        <name evidence="2" type="ORF">BQ5605_C005G03562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MB93"/>
    <dbReference type="STRING" id="796604.A0A2X0MB93"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY77134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="222" mass="24263" checksum="226E92FEBAA9EBDF" modified="2018-09-12" version="1">MAVSATFFDRKEVQIQDDVVVYADALDKPLRKAQSHGQRPATSAATLDGPASTPSDSSTTEGNDADARTRAQLARGSSSRLLGEPDRQAWAAKTNLLSKASRRRFVEQVMECQGVFSNNLFKPDADCRMEALEASGLAQGQDRRGPPTKDILSPRQRPVLVFLGEGGSSRGTQKATYRTNVLCRDLVQEFNRLQERGFVVEIVSVDEYKISSVCSDPPAATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MBQ3</accession>
    <name>A0A2X0MBQ3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C007g04635 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C007g04635</name>
        <name evidence="2" type="ORF">BQ5605_C007G04635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY61984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MBQ3"/>
    <dbReference type="STRING" id="796604.A0A2X0MBQ3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY61984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="447" mass="48514" checksum="8C2E59BFFD02CD1E" modified="2018-09-12" version="1">MRDLAASFSPRRSPNHRQSQSKKETTFAQDLFAQTKLESPRKYNPFAREGTTASPTKRIKLSGGEEAFKRSNVRLGQLFGAARRKSGGLVEDDDDEDQEMLGESPVKNDATKRKSFVPLFDHDEDEEHEASMKNPFLASGADGKRNGKRKKKEDDEPGKKGGAMDGWLRKAVHPTLKAVKRTGYEGAELVEDDEDEDGGDKGEGGSAGTNGQKGKKKPKRAPAGLRYKKIPGGKAPPKKGSTTMAVDSDDGDSDEAVSDRVGKTSRVGSMLIIDLDDEEQHRIVIRSTGEGVGGAGTSKMEEGEEDELVLATGSLIYARRTPPPSSSIPTTSMDEDAPTWHNQDQANEALPEDLASILSLRSSPMKKTASKRMLARDRTVDDLLKGPSAGVNRVKKGLMDLEDEETDKVGEEGVGSDDDWASDVEGWKAVSDGEMDGYEEVEALGRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MBX1</accession>
    <name>A0A2X0MBX1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C008g05066 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C008g05066</name>
        <name evidence="8" type="ORF">BQ5605_C008G05066</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MBX1"/>
    <dbReference type="STRING" id="796604.A0A2X0MBX1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="256"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="50"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY79178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="796" mass="88520" checksum="0A4C26C847375CD7" modified="2018-09-12" version="1">MLAVRALDCLSTADYALASICAMLASSAPRSSRTILGAWNHVPRCIGSTWPPRPAVVTSSGSNSSSTRSSSSQRSFSSSSRSTFLFNRRPPPPTASKLLSELNDARQQERLDLIGKLYPKFAKAARDETEQLAANREATRGTPASPPVFDHARLRSVLAFVASTDRLDLLMRMFTDLHSLRIQPGRVDHHLLLRGLCKAGKTDAALKWIEGMPDTYSVTPIVKDWNVIISGFRRAKQLDRVRATIERMRQFDKRPDVYTYNIAISAAFEADEIAQVRELVQEMQEAEIEADAWTETALLSGFVDKGELASAKIVHRRLVRIIDEEMVGKPSWERDVAAVNAVIAYTCASEGVEAGVQTTNRYRDQGFIPDAWTLNTLIKYGSKQVDTVEVAIKLIEHIEDVTGSVGDRRSWALLIHRLLRASSGGLDQALGLYQEMRDRSVPISSSIVQPLIDGLLSQPSSQSLASAKALYEDLAQASKSYKLGPDYSIYITLLRACASRAHPDLAFSRTLVADMRERGIKLDGTLATWHIIGLMRASSSYEEAFTAYDQIRALDASVYDLQSYNTILSAFTSLKFEKAEDSDPAPPKIILEFLSDMRYSNCPADSATYSLLLSYYSRAPSASTSTIAHLHSLIKLDSSLDPDTPLFNSLMGAYSRVGAYSTAYRIWDTLRLNTGRGPGPKVDDRSVSIYLDTCGFDGSFEAMKRGEDVWASLEKSKFFGVMRNEKHWSSWVEALCRWGRYDEAEKVVFSKEGRSRGGLGMVETLAKMSREDGPERAEKILELVKEHYGEKMKAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MCS4</accession>
    <name>A0A2X0MCS4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C004g02618 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C004g02618</name>
        <name evidence="1" type="ORF">BQ5605_C004G02618</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY66057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MCS4"/>
    <dbReference type="STRING" id="796604.A0A2X0MCS4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY66057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="182" mass="20445" checksum="55FEF130DCAE883B" modified="2018-09-12" version="1">MRLQCTLSLNPAAHNLYYGHFDTQVSSQTKVLVCCNSQVPVPTSAGQVPSNDNCLDVEIEATKARTGLKLADLRTLNEVFAFMELKSSRCEWYAAEAQVLRRLYRMTSTHPIRRWVFAATMCGCYLRVYVQTPAGIVHTTPINCASPNGLRILKRTILRILNGDLDWKIRQAGGQCGWEIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MD74</accession>
    <name>A0A2X0MD74_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="23">BQ5605_C012g06717 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">BQ5605_C012g06717</name>
        <name evidence="23" type="ORF">BQ5605_C012G06717</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY15967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MD74"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0229">DNA integration</keyword>
    <keyword evidence="18" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="16" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="15" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="16" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="17" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="22">
        <location>
            <begin position="457"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="738"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="21">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="SGY15967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="939" mass="101935" checksum="6697708E40DD84DE" modified="2018-09-12" version="1">MSAAGDSAPEAKPPNTTPAPPDVPPLRLPTHTAAFTTTELLRSSSGYQDWVLTIRSHLPSGVVRYLKTGVPLESWPASYVPLWDHYACSLLCASVDSQAVLPGLLPYLDEPLAAPKVWLALCERYGTVSAVDLLPVIQRLLSSDPVPVTPDLFLQYTHSPSLGDSAKMPSATEIFACLYRNVKARPIEAPAAAVATPQPHHGRSRPCLNPSCRKMHWLKECPDTAYRARRNADAQNKRGNSKVSQPTASPAAVDTPESVSFMACLLATLSPFCKLAWLLNSGANRHMTNDRDLFSELHAVAGPRVGGVAGSLSSTGCGTIHIHTAKGPIVVSNVLLVPDLPCNLLSVFQLDQLGYRVSFEARRACITRPSGTVVATAQAVGNNLYALVLGPTPCTPRVLLATPSKVPLLTLHHRLAHLPVVQIKNIVQRGLVTGVDWVYLDEELRDFYCNACLASKAHALPFAHSKSIASGRLDFIHVDVAQMPRPTFGGHQYMLVIIDNFSRKHWCILLALKSDVFPRLRDWILEVKNATGDKVKTIRSDNGGEFTLRNFVDLCLAKGICQELTIPYMPQQNGYVERSNCTIKEGILALLYSSGADSHLWGEAAMYFVHCKNLMPHAGVGGEIPDTCWHGFAPDISTLCAYGCRAWHHLPSAKRTDLDPKAVPLLFVGFDHHTKAFRLFESSTCKIHLSRNVIFRESKFPALRPVTNVCAGPIPLPIVIDAYPDQVDLPEPSLVASPCSLAPRAEPLPPAPVAPDQGPAHGPSPAHDVPDQDSLTPPASDLGSPATPPSLAQFDSPDPMDLLSRPRNVASLCRVQELPDNVDDALHSPLAMAYLASGAATLLETSPSDPTELITPACNPPHWRAAMATPQADEWRLAARDKFDSLLRDFSAFTPIDKSLVPADSEVLGSRFVFRVEWMPKRFRTWDVATAEATGGAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MDF4</accession>
    <name>A0A2X0MDF4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">BQ5605_C009g05444</name>
        <name evidence="15" type="ORF">BQ5605_C009G05444</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="2"/>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY81038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MDF4"/>
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    <sequence length="1070" mass="120894" checksum="5A77022A9A6AB0CE" modified="2018-09-12" version="1">MAEQSEDNLSTDEENEYAPQFISTIPITLHNGKGSQTLHALADSGASSSFIADKVVEKLGLAVHHLPVPTMVKTAIKGQKRAFHVTSYVKIPIALENGTWEAGDTILKVAKLQEPLEVVLGFNFLAKHKFNIDFARHEILVPHPSMPNVMIDLLAPVFGPQPQRAVPRSPKRSDKAWINWGAVIAYIDGVQQKESELAELRAREARLRVEFADRFPGDIPPVSMYKSPVRHRIELKPGAKKPNLKGYQASHRYRAPWKRLIDQHVTAGRLRKSSSEFASPAFVIPKKGMDKDPSIQPRMARFWGKIDMTNSFFQTKMAEEDIPKTAVITPWGLFEWTVMPMGLCNTPATHQHRVNEALGDLIGNVCFVYLDDITIFADTLEEHEQRVRLVLDALRRADLYVSPKKTELFAAECFFLGHQITREGIKVDPDKYLRKFIDKLADLTAVLVPLTRKGAHVDDGWTGEYNTAFEAIKALVGSLPSLHPIDHSEQGDPLWLMTDASNWGIGAALSQGKAWQTAMPAGYWSRQYNLAEGNYAAHEMELLAIVEALHHWRADLLGVRFKILTDHHSLAGFMKQPSLSRRQAWWTEQLADYNFEIVYVQGPENTVADALSRYSFPEDCATRGASDDVNMLAEATLDPAFLKALKDGYLNNTHCQQVIKNIDSTPGYSYKDGIAWFEGRILLPKTGDFCENAIHDAHNATGHFGLHKTYKRLQRDFIWSGMKESCKEYVESCSVCQTMKMYGTGFAGRIHNLNVPDRPMREVGLDFVGPLIPSNGNDALLTVTDHLSGYVHIIPCRTMDNATTTADRFFDGWHQYFGMPQVLVSDRDKLFTSEFWRAYTGRMGTKLAMSTVFHPQTDGRSERTNRTVIQVLRTMVNRQQNDWSKHLATVEFVINSSVNRSTGKTPFEVADQSNKVRKLEPEFAVGDRVLTSHNIFHTSKLRHWTDNDGAAFPGREATEPASVVVQGNEEWEVDRIVDEKGKGKRKRYLVKWKGWADSDNTWEPRAHLEETIALEEWERERAEGERGKEGRGGSLVQVVESAPLRLRLTTTSSRPLWPHACPRARRRRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MEG8</accession>
    <name>A0A2X0MEG8_9BASI</name>
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        <submittedName>
            <fullName evidence="6">BQ5605_C009g05804 protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="primary">BQ5605_C009g05804</name>
        <name evidence="6" type="ORF">BQ5605_C009G05804</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <subcellularLocation>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY86180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2056" mass="209469" checksum="C0D89F266E08D16E" modified="2018-09-12" version="1">MHSTSSLAVEQEASDQDFLNLSLPQQGLTVRISPTADSVDASVPSARGHKANVLAVSNTFGWAVAATEPSGFVLLSLSSLHQLLSTAAPHSTPSLEPQLAVPTPHLVDHLHFAQSDHSLIVALRDGQVLVYSLKQLVQGQTTPQHILPSVGGSLLSIHGCPAEYSPLVLLVSTTPSPPRIINLTSPTASQTAFPPDLKATSACWSVKGKQISVGDIDGLVAQYTPEGQLKGSIPRPSSLSAEYQVRAVEWLENTAWLITYALPTPEGQEPVHADEVFVVNKLGSGEYAHVKFFDPTPAFGLTQFEGKRWTLRLKSWAPFKHLLFLANKPSADLGAIAQFEDDGQWKGLVLPDASRPTLPMGENGDDVAPVGLALDLTGEAPIILVLTTQGVLVSWSVANSNAPQPYQGLVKAKDVTIESEPVAQDAGAAPSSAPAAPTSIVFGAPSSSPFAVASTSSPSPFGPSAFGSSAFGSTPAFGQTPALGTSVFGAAASGSSTPPVVSSGTPNAFATFGSSSTSATGFAGFGSAATSSGFGAAAAATPATSNRGSIFGSGSAFKAAPAFGKSEEAPSGSATPFAAAATTTNAFGSSTSSPNPFGSKASAAPATNAFGTSTSTPTFGASNATPAFGAPTAAPAFGAPAAFGSSSAFGTTTASSFGTASPSPFAAPTSSNAFSAFGGGSSSTNNAFVATTSGGSSGFGAFAAAKPANGASIFGSGGALGSSTSSTPGGSSTTISAFGNGGSAFGAGGSAPAFGTGSFGGSPASTTAASTPKPSFGLRKDAFNSDDEDEDVDVVDDSGARVDEPPDLEPERTGLDLNASLKTAKTSSERIAEKASQGSAGSFGTAVSGAFGMGSLGLGGSTTPAATTPTSEAKQLSVSGSAAAASPTLPPTPTPKPAESPAALPSPPAAPVSFKSGFGGFGPAPSSTPPVGFGFGVGPSAPSTFTSNTPVPTTPALPKEDSDTQSTPTESKPITTSAKTPVSTPASAKSLFGFASSPPSTPSLGKSSGETEGNSLLSRLGRIEGDQDEEGEDEEYDEEAYDEEGEYEDEEEYDDEGEGESEGEYAEKEGDTNEQEEDVQDDDEDGDQEEQDVDASSDAANDEQAQGTSSPSPVPTKEDVKPALKAADEPKPEATPKAFAFSPASSPPSSAPTSVSAPKASPFAPTAPASPAISDASSQRKSSPPTFSFHAPAPVPAPKSSAPAAVSAPSTQGTTKPPLFSGGSFSGFGSSVPRVPSPLGVPQNSAPSAAPAFSFAQAPKQAATSEATKHALSFGGFGAPLKPTASTSPLPSPLSTSPASASPFAFAAPSTPKAEPKPNFSFASMAPKETSKNAISFAPAAPKREVVKNPTFSFGAVSASSSSPAPSVPAPQQQAAQRASVADLSPPPKLGSQLVKAAEPVVKEKGMAGELAKAYLRMQTDFEIVARNTVILRDFVKAIGKPCQVDASSSEVAEDLDPRYWSLGDLSKLRRALLDVQPGVGKLVEEAKKQKMQVAELQALMLKGGSEEAARFIRAKDDPVFAKIVRVRQLGPEQLENQKRLRLAMTVSIWLYMLARWDSILTVIHSQTMKATLGQVEDHVSVLREKMVESRLGRTSFKAPSLDSVNRAVRNISSAVAEKTFELDELTVRLELMRVQPASTTSLSRSARARSASITENSMNTPSILRASPGASVKALSSPGTTQLRPDVLATAQAALRAERSCAILKRALLHVQGPVSRLNQSAREKASSNAHEDIADLQLAFSRGPITGDRLPLPRRKPERPKTPPPAPAPVAPIIKAEPPGSAFGLSMSSSSPFSSAESQNSAAPPPLTFKSAPQFSFATPIVPTPSSPLSGPSGGSGVSRGSKISSSRSSAVKLRSSESVVAPESEGRAAVPKSTFDWNLPAAGSSNGSGASGPSTSGDRKPIGFVPFAAAPVASKLFSAATTPPAQGSAGFSFAATPSASTGFPALSGAPSFSFAPPSKIASPAAGSAASPTFGFKGFAPVQDPKAFGSAAASLQLQHGDDEDEEYDDEEGVEDEEDYEEQEGDEEQDEDGEWDEDEEDEEEGLDTIVEGDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MF33</accession>
    <name>A0A2X0MF33_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C005g03350 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C005g03350</name>
        <name evidence="2" type="ORF">BQ5605_C005G03350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY74232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MF33"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY74232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="64" mass="6783" checksum="290BB0B6C7601DFD" modified="2018-09-12" version="1">MERNKATTAAEAHVPYSKQSDSGRSCSLALATKILSADLNTKVSTMTGTFDDLVQEPTLPGGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MF72</accession>
    <name>A0A2X0MF72_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C038g11726 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C038g11726</name>
        <name evidence="1" type="ORF">BQ5605_C038G11726</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000061">
        <property type="protein sequence ID" value="SGY92252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MF72"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY92252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="43" mass="4830" checksum="D38E4A4A632CA1D3" modified="2018-09-12" version="1">MLEDARIALALEVRLDSNRPQLVIILAELGYLNLPRLLSNVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MG52</accession>
    <name>A0A2X0MG52_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">BQ5605_C035g11436 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C035g11436</name>
        <name evidence="13" type="ORF">BQ5605_C035G11436</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000064">
        <property type="protein sequence ID" value="SGY97998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MG52"/>
    <dbReference type="STRING" id="796604.A0A2X0MG52"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07489">
        <property type="entry name" value="Peptidases_S8_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010435">
        <property type="entry name" value="C5a/SBT2-like_Fn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034187">
        <property type="entry name" value="Peptidases_S8_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF66">
        <property type="entry name" value="SERIN ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06280">
        <property type="entry name" value="fn3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015911111" evidence="10">
        <location>
            <begin position="23"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="11">
        <location>
            <begin position="199"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="C5a peptidase/Subtilisin-like protease SBT2-like Fn3-like" evidence="12">
        <location>
            <begin position="648"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGY97998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="966" mass="103229" checksum="ADC3F17C984D3B65" modified="2018-09-12" version="1">MFVNMNLSLALALLTAGSTLRASGTLASGTSAAAASKSAKFSKAIADTGKGTSRIIPGRYIIAVSGSTGTLSKRDSQVAISSVLSKIGNTGIDVKTHKLYQSPGLLTGASILVPANTTEAHLLDIPGVTHVWPVRSISRPKTFSSSGSASTSHPSGTDSSELVRRAPLESRGDEDFKNDQFPPHQMTGVDKMHAKGYLGAGIKIAILDTGIDYKNPILGGCFGKGCKVAFGHSFVDDEGDFINGPDPYSTCLEHGTHVAGTIGANPNKYGFTGVAPKATLGMYRIFACSGSATDDTIVAAILRAAEDKADIISMSLGDPGSWLDSTAPQHVADKLLAQGMHVIVASGNLQDEGLFAASTPAATRSGISVASVDADVVPGYNLVFKTGRYPPMSYFSAMPFETEDVLSLYFTSPESAKEVACETLPDSTPNLKDRLVVVKRDQCATDDMFTNLAAKGARFALVYGSVGSENQPYYDTQGTNLTAAGGISNVNALELLKYYRAQRSKGPKVAFPSKQLRLEQVLSGGQVSDFSQFGPTNDMFGQPSFGAPGGDILSTFPLSWGGVGVISGTSMATPFVAGAVALILSARKSERLTPVQMRQLLSSTSKSIPVKRGTKSPLTTVVLQGGGLIQVDKAFEAKSYFSPNELYLNDMAHFAATQTVTITNKNSKAVTYRYSDTGAQPRLVYDKKGQYSPSLSPVTILPGKTSTFQIKFQPPQFSAGQRSLFPVYSGFIMITADNKESFQIPYFGLTGNMRDMQILDQTDVYAGQYMAGLRYPYVADSKLGLQSNPNFVRSYEMANGPIIAFRLSQATRAYNIDLVFANKTFRSTISPANNAGLLLGSTKTAKVELQGLELARNLGESSSLGPRRESQSYASVPIVGRIKGALNVPRNLAVDGQNRFSFTDQKVFNGRYQTTPTSRRFETAKLGTVYRFLLRAVRTTADPADEGSWESWLSPPFEFSAIYDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHZ7</accession>
    <name>A0A2X0MHZ7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C039g11787 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C039g11787</name>
        <name evidence="9" type="ORF">BQ5605_C039G11787</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000060">
        <property type="protein sequence ID" value="SGY90070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHZ7"/>
    <dbReference type="STRING" id="796604.A0A2X0MHZ7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF18">
        <property type="entry name" value="NICOTINIC ACID TRANSPORTER TNA1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G03820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="466"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="87"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY90070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="535" mass="59432" checksum="3C1FBBB4EBF462A1" modified="2018-09-12" version="1">MDNEKSRPVDAPGTYRSEPYKHEQLMQHIEDSSGQSTASEHAGEGSYSNTHNGEEIVKPSRMFTPEEEAKIWRKVDLRLLPYLALAQPILIPQLYLLSFMDRGNIGNARLAGLEADLKMTGDDYAIALSAFFISYCLFEVPSNLMLKKLRPSIWLSSITIVWGIVMTLIVHNFAGLVATRVALGIAEAGLFPGVILYLTLWYPRHMCQQRIAFFFSAATLAGAFSGLLAYGIQFMSGVGGRNGWSWIFILEGLLTTLAGIGAFWAIVDSPRSSHFLTKEEQDFIIWRKTTDSGASGEATNVSWTYIRQALTSWQCWLALGYYFGIVVPLYSIGLFMPTLIQAFGKYTRPQVQLLTIPVYVFACIYVLITAIYADRMKTRFPFVMAALGLSALGIIINLTPAPSGVKYFGLFLTAAGSYGGLPAVVTWLSNNLSGQTKRGVGSAFQIGIGNLGALVSSNVYRKKPRYFLGHGSVLGCIVLGLFCAPLYAYLLKRENEKKEREIEFQNSLPDHEKRVYSLQELRDLGDKHPSFVYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MI72</accession>
    <name>A0A2X0MI72_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C030g10832 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C030g10832</name>
        <name evidence="1" type="ORF">BQ5605_C030G10832</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000069">
        <property type="protein sequence ID" value="SGZ08996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MI72"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ08996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="72" mass="8227" checksum="46CCD2821BA602A6" modified="2018-09-12" version="1">MEGDGALDSALKEKDIELERQLAKLRSTIDPDSFNKRFSDAITDSHKELCRVLTWQYVSICRRLLSLSSKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIR5</accession>
    <name>A0A2X0MIR5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C009g05802 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C009g05802</name>
        <name evidence="3" type="ORF">BQ5605_C009G05802</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY86144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIR5"/>
    <dbReference type="STRING" id="796604.A0A2X0MIR5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07383">
        <property type="entry name" value="MPP_Dcr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440:SF11">
        <property type="entry name" value="METALLOPHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016034673" evidence="1">
        <location>
            <begin position="25"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="71"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY86144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="414" mass="46291" checksum="8360852DB69B226C" modified="2018-09-12" version="1">MQMTRTGCFLSWCFLCSGALVARGRTTDHLALALSSVAAAFPGSKHCGPKPCKLCFNSRNNRLHFVNGVFRTTVFTDLHYGEAQGIEWQPWGKLQDDTSDHIMRTILQAEKPHLVVFNGDQVTGEGLLAENATDAYDNCLKVTVNSNTPFAAIYGNHDNAVNISHTQLYEHEKLNYKDLSMTQANPDSATDQNGIYNYVLPVFEDRTAKAPSLLLWFFDSRSGIFPNPNQYEDWVDAKVGPWIKSTADCILSTYKLRSLPPSLTFVHIPVSRMKQLQHGVVDLRPPSYRPVFINDDPVDSQGEHHLAVHKPDAPFWTALRDTLNGANENGVIATVVGHDHENDWCAESNTSHWPHCFARHTGQGGYGVQARGSRVIEVRSGLNRKNKETQVLVAHSWIRLGTGEKISKSRLWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIS1</accession>
    <name>A0A2X0MIS1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Imidazoleglycerol-phosphate dehydratase</fullName>
            <ecNumber evidence="4">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C039g11825</name>
        <name evidence="9" type="ORF">BQ5605_C039G11825</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="4"/>
    <dbReference type="EMBL" id="FQNC01000060">
        <property type="protein sequence ID" value="SGY90740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIS1"/>
    <dbReference type="STRING" id="796604.A0A2X0MIS1"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.40:FF:000001">
        <property type="entry name" value="Imidazoleglycerol-phosphate dehydratase HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="entry name" value="Imidazole glycerol phosphate dehydratase, domain 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133:SF2">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE HIS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00954">
        <property type="entry name" value="IGP_DEHYDRATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY90740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="245" mass="26273" checksum="9B13F8F7CC9819F3" modified="2018-09-12" version="1">MSRTIRSASISRKTNETDIAITLTLDVAVGAAQEINISTGIGFLDHVSLPCSNSRVVSLLHADVDSAVPHLSSLMYHALAKHSKMSLTIKCKGDLWIDDHHTAEDSALALGEAFKLALGERKGIRRYGTGFAPLDEALSRAVLDISSRPYFCGDLQLKREKIGDLSCEMIPHVFQSFAQGAGVTLHVDVIRGENDHHKLSSTGQGEGWSLPTAESAFKALALAIREAIQTDGSDDVPSTKGVLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIX4</accession>
    <name>A0A2X0MIX4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C011g06657 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C011g06657</name>
        <name evidence="10" type="ORF">BQ5605_C011G06657</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-5A family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIX4"/>
    <dbReference type="STRING" id="796604.A0A2X0MIX4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045901">
        <property type="term" value="P:positive regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006452">
        <property type="term" value="P:translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04468">
        <property type="entry name" value="S1_eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000007">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000034">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001884">
        <property type="entry name" value="IF5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048670">
        <property type="entry name" value="IF5A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020189">
        <property type="entry name" value="IF5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019769">
        <property type="entry name" value="Trans_elong_IF5A_hypusine_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00037">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11673">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01287">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21485">
        <property type="entry name" value="IF5A-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01376">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00302">
        <property type="entry name" value="IF5A_HYPUSINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7" id="KW-0385">Hypusine</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Translation initiation factor 5A C-terminal" evidence="9">
        <location>
            <begin position="94"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY12924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="242" mass="27263" checksum="103AD364140A4E40" modified="2018-09-12" version="1">MMSDTEQTRDQEHEETTFESANAGASLTYPMQCSALRKGGYVVMKSKACKIIDMSTSKTGKHGHAKVHLIATDIFTGKKLEDISPSTHNMDVPNVIRSEYQLINIDDGFLNLMTTDGTAKDDVRLPESEIGDQIQAAFDDGTDLLVTIIAAMGQEQAIAFKEAPKILPDERATQSVSGQTRGHNPWRMEFQQRDEFVEKLLLEYRQYTRGLNYGPTENCLRRLHRAGRRCNRMRALREPSHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJ49</accession>
    <name>A0A2X0MJ49_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C029g10643 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C029g10643</name>
        <name evidence="1" type="ORF">BQ5605_C029G10643</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ15112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJ49"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ15112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="119" mass="13875" checksum="E91E7C5D0C078683" modified="2018-09-12" version="1">MIMGDCQISKHLCVVVATPQYLRHKIAPVHSRFPSDLVRTFRRDRQRVQALDLEQLLERIVDEAMSLNSSLPSNLSLTISTVKWVSPEPPPIDRIAEWWECEAESFEMERWEGEREVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJE3</accession>
    <name>A0A2X0MJE3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="26">BQ5605_C029g10733 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">BQ5605_C029g10733</name>
        <name evidence="26" type="ORF">BQ5605_C029G10733</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ16154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJE3"/>
    <dbReference type="STRING" id="796604.A0A2X0MJE3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <keyword evidence="22" id="KW-0862">Zinc</keyword>
    <keyword evidence="22" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="24">
        <location>
            <begin position="298"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="25">
        <location>
            <begin position="510"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="312"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="SGZ16154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="699" mass="76281" checksum="CBBC48CBD0B6E0D0" modified="2018-09-12" version="1">MDSSPASPLAPRDPSSPESSIGEQIATLQAQLAALQASQPAAAAAAAAATPAVTAVPGNAATASKVVFPKHARLDGPKSFTNWLRQLRLALPNQVRGYVLDGVMPPTWTADQLAARDDAAREIIVGSIDSADVSATLDAIPSDDLSAPRIFAALKARFAPDDATRTLELFARLWDFRKMPASVEAYDAWLREYMSIAQEIRDAKTSLNDVLATHVLAMVPSCLDSFRLTFTDEQRNRRDLPELTTLTDRIRIQLRSAGLSTSHSAMLATSSPCPACRAPGHRLRDCTSRAKHPPTGPCRRCHKKGHWALDCKNRGEQARRSDDTQDDTSSSAALQPNVGYFASCLFARRQLPTDAFVVDSGATTHMVADRSLFTTYRQTAHTKIGGIAGGITAIGMGDVAFVAKTGHPITLRGVLHTPGLHVNLLSVARLCDTDRVRLAFTSDGIDIAKDGQAIAHGTRVNDGLYLLDADHTKCLLDGFGAGYSDKDVEEFVCNACLGSKGHRLPFPDSESHSPERLGLVHSDVLSFPTPSLTGKRYLVTFLDDHSRKLWAYAIDHKSDVFPIFQTWLAEVELATNARLRILRTDNGGEYRSNAFTEFCKSKGIRRQYSIPYTPQQNGRAERVNLSIVEGVLALLADARLPATFWDEAAAYFVYCKNRCSHSALAKQTPEFVWNGQRTTATALHPFGCTVMLSRLLKQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MK73</accession>
    <name>A0A2X0MK73_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C021g09273 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C021g09273</name>
        <name evidence="3" type="ORF">BQ5605_C021G09273</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000083">
        <property type="protein sequence ID" value="SGZ20408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MK73"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ20408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="333" mass="34534" checksum="8FDF857ECFDEF91A" modified="2018-09-12" version="1">MLSSPEAMLSSPSPRNTAWMTHTRSTSLDLSPSISTVLGSPLTTDFPFPSVGNGIISGDDGASGSSSALSSSPALGYGSPRWSTIPVAPYSPPPMYAPPGAIFSLGVPGTPGMVFLGPGGGTAAGVFRDSLASRRNSRHHKASKLLERSYLQGVECLLLVEIIASIILILIYFHLYAFSEPSSPSGPINRGPAAEPSARQPSRPFLAFIPTPTSQPSTLLATSAYLCLVAAFRTGVHRIALSLDPVSGMDNLDGGKGLAVPMATLGAAVGIMHLPLLVTLRHPTIIFGVAAWGLTALLVGGILYDSLRRATNLEEACNGDLASLPEDKEMGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLC1</accession>
    <name>A0A2X0MLC1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C012g06729 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C012g06729</name>
        <name evidence="1" type="ORF">BQ5605_C012G06729</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY15996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MLC1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY15996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="45" mass="4947" checksum="8E614E1612C8678A" modified="2018-09-12" version="1">MRKSLPNRGQGRCKDLFEALQLAISRLRLTIPARARPLGTIPGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MMC7</accession>
    <name>A0A2X0MMC7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C025g10019 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C025g10019</name>
        <name evidence="1" type="ORF">BQ5605_C025G10019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000087">
        <property type="protein sequence ID" value="SGZ26991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MMC7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ26991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="282" mass="31487" checksum="3068E75FED0A3649" modified="2018-09-12" version="1">MWWRFYAAPTFADVGVSTERTNTISVTTMRYHSSSRSPVVHDKILWLLYDIKSIYGKTPTADYRLGFGVMNTTAYLILQFASLANITLGLHLPSVGFSRVFSHEYTPNRGLAEQAVRIFVFGQDSQDGFKLQISEDVTEPGNDIALYVASRQFDATGVCPRTFHARSDVASGTALVLCHKDRRYRSLIDKEHAPTIQHLVHAIGESEHNLRQATKSGNEVSTQVVFAFSDSGNEVSYRQRVLFFDQTAAPTAIVYGTRTVTKARSVRGMFVGREALRSFASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MMN2</accession>
    <name>A0A2X0MMN2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Outer kinetochore protein DAD2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">BQ5605_C029g10700</name>
        <name evidence="19" type="ORF">BQ5605_C029G10700</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ15784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MMN2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013963">
        <property type="entry name" value="DASH_Dad2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28036">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28036:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08654">
        <property type="entry name" value="DASH_Dad2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00030568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="SGZ15784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="185" mass="20834" checksum="23B5110325B07DFD" modified="2018-09-12" version="1">MSYHHHPRASSLLPTESHHSSGFTPSMQRLMDKQREYEAFYKIHQQSQQLLDFLSQFSDQYMVLDGGSEGQSRVQRWRSLTHCWLGVPRDHATRRVGKGAARPDFGVLTVVLFPAVGDVVEHWQTAFRATHLALASLEQQRKEAEASETSTHNLLPERLVRIPVATPNEVDDPAAASYDPAESSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MN78</accession>
    <name>A0A2X0MN78_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C027g10318 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C027g10318</name>
        <name evidence="2" type="ORF">BQ5605_C027G10318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MN78"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ28347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="449" mass="49732" checksum="8784067ACCAE8447" modified="2018-09-12" version="1">MYQHSVVSAAPACGVHVPIRSHVQALCAPTHPTTTSSCAKARKGERAGLESRSNPSSPTFSQGKVQLPPPLRHNPECRQLREGSDSEAIALRENARSYNNALLTLLAAHFDQTRLGILGPRVSLSSIHAPRHSTWTQRRRQSHTKAYFDQARVRLAQAGDTAKEWVLRLCLPPGRDRRTHNLPPPSTEMTMLICDSDTNTGDRGPQELIVQVCSHRCPDGRPKYQVVSSLHPSAMPLRYPTLFAAEENSSHLNTPLCGFHQAGPPIARNREQIDNGVQLREVLPVSVWMTNEEDKDRDDEDEDREEGDEEDGDGERQRSSKGVEVASLAFTILCALLAKGDEYFSIPHCTHGPFLESVIYGYTPSRDRSTLHIRLHQENLHLTTTQGINGLAPNPIGRCTGADKACNRPDLIARVFEAKSGNKRHAGCFGDECKMNGFCFFAVLRVVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNP8</accession>
    <name>A0A2X0MNP8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C003g02397 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C003g02397</name>
        <name evidence="8" type="ORF">BQ5605_C003G02397</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY40570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MNP8"/>
    <dbReference type="STRING" id="796604.A0A2X0MNP8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051598">
        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007130">
        <property type="term" value="P:synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051294">
        <property type="entry name" value="HORMA_MeioticProgression"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48225">
        <property type="entry name" value="HORMA DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48225:SF7">
        <property type="entry name" value="MEIOSIS-SPECIFIC PROTEIN HOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="7">
        <location>
            <begin position="35"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="649"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="741"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="854"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="659"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="757"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="788"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="854"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY40570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="896" mass="98386" checksum="600FC08AB6AE98B9" modified="2018-09-12" version="1">MATRVRPTAATTANRAPIVGAAQQVDENLATTTYTSSLTHISQLLRTGISCVTFLRGIFEDELSLLFGLGSQDNFVNAAIRTPSVPVSDTNPAATSKALEEKKSQPSTVKVKSLIRGASREADLLLDYLDSVDAAFKLGYVERLVLAIFHDPEEPDNIVEAYTFSFDYEADADGKQRIAMTLPDQWTGTGKGGQSSSLSEGDVKRQIQKLIKNLLMSTQALDELPRRRYIDMRLYFTENAPDDYEPALFQPIPPDEGQLRITTPRLEDRPDVAELGDISTGFHNLSCHYISIAHLLNTVFDDKITHEEALARNRRDAQSRNVEWDGESLALSITSADSNLKPMDPVGVRDNDGNILTVEEICARQDPQTKQLRLKVGLEGTGATVIRTEDHFEPSIQDSNISDSAALQKELNIIMLKIDRIKNRGGDTQLLEITQPQPNHPPALIEELHGFQDLQMSFSQDDDFYRSNVRQDALQAGFPLPSEQAPRIVVAFENGTNSAHQNVPARGRTSQTSSALAEMMNRCDCGMPWIYGSIDLSIFILKALSAAPVLCQISKHFSCYGFATRPHAAVLRNLICYACRTADVTGLRSHEFMLNFHELAKFRRAIEVLWNDGVPLVSELAARLGTDRQDAAAIIQRLRCENFIVEEKPQPKEEPVAKGRGRGRGRPRGRGAPRGGGATRGRGAASNGSGSTQKVDVVNRSPEQSRYKKVKYFTPGQGAELPILELLSREAKLVVVNQRRAPENEIRPPPHNGHASPASTDSIIQTQPQSAAQTVNSQVANAPDLAQASASTIVPDTPETSQVLPKPSRTGQFADEIQSSEMEITDSLGFAPSTFEETSAFPKRAAPIAQEALSEKAKGKRKAEEEVPQGGENYGTLKLPLQRKVKRSRAIEALEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNZ6</accession>
    <name>A0A2X0MNZ6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C014g07669 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C014g07669</name>
        <name evidence="4" type="ORF">BQ5605_C014G07669</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY19519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MNZ6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029191">
        <property type="entry name" value="Uds1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF40">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15456">
        <property type="entry name" value="Uds1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Up-regulated during septation protein 1" evidence="3">
        <location>
            <begin position="204"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="263"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="338"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="505"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="701"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="877"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY19519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1054" mass="115634" checksum="B735E25DA00A48A7" modified="2018-09-12" version="1">MVNHSTNNNELRQSNLDDGSDFKKAGGGGGWFGGAFGEGSTSANAQGQGHEYGANPNSNSNSNNFNSSLGAGSNNTRNYASPPTTTGLASPYHGATRSHDAGGISPISPPYDSGAAAFGPQAASDDLEALKLPFGGRSTPRSPSTRNVHTRSSSQASSILLQNSTNGLSSSRPFSPLGMSQPSLSVSVGSGLTTAPDVKDKIMIDLLSGQAVVETKDFPILGWEEMQDVKKEHAVLATKIASLSRSLALETRLRDSAAKLVRLSSPSPIPGSPTPASASGSDASNRARMTKAQAESQVQQANEKIESVQTELYKVGWKEAESRTKLLRHMAGVLGLAMRRKEEEERGSSQTPLSGPRGLHSQATSVGRDQQRSSSPFGCPTKSRFDGHSFFAGNKEAILPGPSTRSSPYASPNLSASNNGQFVVAGADTSHAAVRDLETQVAGLQRALNEQRDRPIQQVDSAQLRELQEEVTQARAAERWVRDEHTQTRNELDRHLMELSSIKNSHGSLQRELEQTKQGQGQGEDAQRELERSRQEIDEMTDKMQELEQELNDLEERAVASDRRVTDVEGLLEDMKIKHAHEMQRAQGDLQVAKEEAERARLAVARVPTPNGTEEEEQRLRDEVVSMRSERTKISQTLADVLQRHRAHANSLGTELPKDFDETAVDHHDDWSGYVASSLGDHFDHITSHATAVSDELSLARLAQENSANDLEGELRQAQEHRDHWQDEAEQHRLAREQLEVEHDDLKATVQGHEERLASLALTHQELEVSAEEKEHLRAQLEQAQGRITELEKQIADHDATQAALKKLWQSLPAIDTRRRAGDSHDLATLKAAFDPSQSLGDSSAQFSIDALVERVRALLTDDAKLVETLMKIESGTASAQQEVETHRSNAERYQNLAEQHSTNLTVTQSKVKDLEERIEVSSQQAVTMLERLNDLTESLESTRAERRKLETAGKGLEGQVEAAEEEKNRLAAIVVGLKEENRAMKERPDHTAKLASLENTVQDLKDQLTDLEEELEDTKKREQKTRGQLLEELNAAQAVSRGAKTMLTRAIDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPF9</accession>
    <name>A0A2X0MPF9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C017g08421 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C017g08421</name>
        <name evidence="2" type="ORF">BQ5605_C017G08421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY19989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MPF9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY19989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="74" mass="8206" checksum="E7FCED3A2A13484E" modified="2018-09-12" version="1">MPKNQHVSGNNVIQTKGDGNQVTKDYNAVLNGYNGLYNNPQQPQQKDYAQAQAHQLGQQYHAQHQGSNSAQGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQB9</accession>
    <name>A0A2X0MQB9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C044g12174 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C044g12174</name>
        <name evidence="2" type="ORF">BQ5605_C044G12174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000114">
        <property type="protein sequence ID" value="SGZ31439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQB9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ31439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="228" mass="24819" checksum="3067FB333AA6A6B9" modified="2018-09-12" version="1">MTYCEITPLISHNRVVLLKGRHGATTSTAQDSDPTSKAKLSEHGEVHSSVLRGLVQSMGAARLEAVSGVARSVRWTGQGTFSRFSTANETDNIRYIEDGRKEVRMQLRARQYTAFAKIPMFGSIDGNVTSATPLKIGSLVCFGLKRGITPVSCDASNIGEEQLSIGLDSTLHVCQGHANHCDRAETDPLALLSNVVLQELRVVSKGRYSTHMIDGTTRFFGLDARQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQE1</accession>
    <name>A0A2X0MQE1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C026g10146 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C026g10146</name>
        <name evidence="1" type="ORF">BQ5605_C026G10146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ27623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQE1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ27623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="55" mass="6337" checksum="D7109294941FB5E5" modified="2018-09-12" version="1">MESLPCLHIHTRWSVGSVLKYTAVATTFEERVDSDRPQLVVIFTELGDLDVPFMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MR18</accession>
    <name>A0A2X0MR18_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BQ5605_C027g10377 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C027g10377</name>
        <name evidence="11" type="ORF">BQ5605_C027G10377</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GTP-binding elongation factor family. LepA subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MR18"/>
    <dbReference type="STRING" id="796604.A0A2X0MR18"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097177">
        <property type="term" value="F:mitochondrial ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000015">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000007">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2570:FF:000001">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000004">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="entry name" value="Elongation factor 4, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512:SF7">
        <property type="entry name" value="TRANSLATION FACTOR GUF1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="TRANSLATION FACTOR GUF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="110"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="119"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="195"/>
            <end position="199"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGZ28572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="747" mass="82191" checksum="64426BBCBC3DC7D0" modified="2018-09-12" version="1">MSIDLPTLHRRVTALTHSLGKHTSSRRRFVPLIFWRPSSSTWTSTVVRSHSTSTPTRHRTQTLASTCTPPCARFFSSHAPRTAPQPTSSTILKPLQQSPSHFDLSHYPPERIRNFAIIAHIDHGKSTLADRMLEMTGTIPPTQISHDRLEEAQKNEQVLDTLKVERERGITVRAQSASMFYTAQDGHQYLLNLLDTPGHADFSSELLRSLLPSQGALLLVDAAQGIQAQTLSVLDEARKRNLTVLGAVNKWDLVKDDGRGEAAVQELAALLGCEEDEILRVSAKTGLGVQDVLEGVVKNIPAPSKGDKGDKLSALAFDSYFDPFRGVVSLVAVVEGEVKKGDSITSTTTKQAYPVLDLGILSPREISIAEHKPPASTILRKGMVGYIVCAMKDVQDAFLGDTFHLTSHPKPALESFKPLKSMVFAGVYPVEPGGFPKLEDAIRRLTLTDRSVTSNRESSTFLGQGFRLGFNGSLHMDVFRQRLEDEYGEEVIVTRPLVPVKSEFVCLLEHQWWGLIPNSSGLSTLLTVIYKNGKESIIDNPEDFPDPAEMNKVTSVLEPFIRATIVAPDEYTGAIINHCTTHRGVPLSHTYLSTPSTPSNPSSSTGRITLLWSLPLSSIVTNFHAGLKSVTSGFASFDYEEAPYEESSLCRLNILINGTQVDALCSVVHKSLVEKEGREWTKRLKEVVPRQQYEVVIQAAVGNHILSRERIAPFKKDVTAKLYGGDVTRKVNSTLGLCITQLLDGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MRM9</accession>
    <name>A0A2X0MRM9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="19">BQ5605_C026g10265 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">BQ5605_C026g10265</name>
        <name evidence="19" type="ORF">BQ5605_C026G10265</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ28056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015845175" evidence="17">
        <location>
            <begin position="23"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="18">
        <location>
            <begin position="405"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="686"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="741"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="778"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="SGZ28056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1359" mass="149757" checksum="040AB9B36659729E" modified="2018-09-12" version="1">MAPLWFLSCSSNFLVWSPLVLRSETYHCLSRLLAQPSYQCGHLRARPSLYFFTLRNMSDAGASAPEAKLREPKPDAPPLRPPTHSVAFATTELLRNSSGYRDWVLAIRSRLPSGVVRYLNTSVPLESWPASYIPLWDHYACSSICASVDSQTVLPGLSPYLDESLAAPKVWQALRERYGTVSAVDLLPVIQRLFSSDPVPVTPDLFLQFRDSFENDARLLQDSRVTVNALLASHFLARLPSSFDAWRTTFVAAQGDSTAMPSATEIFTRLYRDVKARPVDTPVAAVATPQARHGCSRPCPNPSCRKLHWLRECPDTAWAAAYRARRTAEKKASQPVAPPTPCTPKALLAIPASVSLLTLHRRLAHLPVAQIKNIVQSGLVTGVDWVYKDQELRDFYCNACLASKAHALPFARSKSIASGRLDLLHVDVAQMPRPTFGGHRYMLVIIDDFSRKHWCLLLALKSDVFPRLRDWILEVENATGNKVKTIRSDNGGEFTLRNFVDFCASKGIRRELTIPYTPQQNGRVERSNRTIKEGILALLYSSGADSRLWGEAALYYVHCKNLMPHAGIGGEIPDTRWHGFAPDISTLRAFGCRAWHHLPSAKRTDLDPKAVPLLFVGFDQHAKAFRLFEPSTRRIQLSRNVVFRESEFPALRPATDVRTEPIPLPVTVDAYPDQVDPLEPSLVASPRSLAPRAEPPRPVPAAPDQGPHRPAPAREVPDQDSLAPPAPDQGSPARELPDPESPASSASDQGSSDSAISTPCPSPRPVASRALPAPPSPARSDSPDPIDLLPRPRDVASLCQAQGFPDDVDDALHSPSAVAYLASGAAALIETSPADPAELIAPARDPPHWRAAMATPQADEWRLAARDEFDSLLRDFSAFTPIDESLVPADAKVLGSRFVFRTKRDQHGQVKSYKGRLVARGDSQRSGIDFDETFAPVAKFTSIRALLALAAAHGYHVHQADIDKAYLHGKLDAPLYIRVPDGIYMPGKVLQLHQSLYGLRQAGRIWNDEIDSALSALGYVATESDHCVYVRTTGDVHHYIALYVDDLLMISPSLPEIERTLQGLEQRYGVKRLGEAEYVLGIQIRRSPDGSISLSQEQYLKDVLARFGMSDAHPVATPMPPDLRLEVELQPTPFPDRTRYLQAIGSLMYASTGTRPDLAYTVGYLARFSHSPSAAAWGAVKHAFRYLAGTLSHGLRYARGNPAPLLGYSDCNWGACVLSSKSTMGYTFVYAGAAVSWSSRLQSRVADSTCDAEYLALSHAGKEAIFLRRLFGELGLSSSKPVLIYGDNQGANALTKNPVFHARTRHIRLREHFVRDMVSMGDIVVQYINTGEMTADIFTKALSRDLFARHRGRLGICAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MST2</accession>
    <name>A0A2X0MST2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C044g12123 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C044g12123</name>
        <name evidence="2" type="ORF">BQ5605_C044G12123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000114">
        <property type="protein sequence ID" value="SGZ31280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MST2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ31280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="342" mass="36820" checksum="A013FC905CB20309" modified="2018-09-12" version="1">MPACRAPGHRLRDCTSRAQHPPTGPCRRCHKKGQHTSSAAQQPNVGYFASCCSLAAILPTDAFVVDSGATTHMVADRSLFTTYRPTTHTKIGGIAAVSRPLAWGMYRLLPTPDTRSRCAAFCTRWAFTSTFSPSLAFVTPTSVRLAFTSDSIDITKDGQAIAHGTRVNDGLYLLDADHTKCQQLAFLSRSESTVPLITLHRCLGHLAPSSIQKMIAAGLLDGFGAGYSDKDVAEFVCNACLWFQGPSSSFSRLGVTFPRETWSRCTAIDVFPTFQTWLAEVELETDARLRILRTDNGGKCEESTLRSAQDLGARSEPGADLGARSEPGAPAQDLGAQSEAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MTR0</accession>
    <name>A0A2X0MTR0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C045g12234 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C045g12234</name>
        <name evidence="2" type="ORF">BQ5605_C045G12234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000115">
        <property type="protein sequence ID" value="SGZ31699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MTR0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ31699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="85" mass="9325" checksum="CEF676D8B332844D" modified="2018-09-12" version="1">MSHGKCNGPAQFQTSGSVGQCANSAVRGPTPCGHWASLHDAPPSFFLRLFTPYPSPPRACDIRLKRSSWKLCNEYGIKKWLPHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MUM3</accession>
    <name>A0A2X0MUM3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosome subunit biogenesis protein NIP7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C065g12809</name>
        <name evidence="9" type="synonym">BQ5605_C019g08813</name>
        <name evidence="9" type="ORF">BQ5605_C019G08813</name>
        <name evidence="10" type="ORF">BQ5605_C065G12809</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6 7">Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with pre-ribosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NIP7 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY22539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000133">
        <property type="protein sequence ID" value="SGZ35241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MUM3"/>
    <dbReference type="STRING" id="796604.A0A2X0MUM3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21146">
        <property type="entry name" value="Nip7_N_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21151">
        <property type="entry name" value="PUA_Nip7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.10:FF:000002">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.220:FF:000001">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040598">
        <property type="entry name" value="NIP7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055359">
        <property type="entry name" value="Nip7_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016686">
        <property type="entry name" value="Ribosomal_synth_fac_NIP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005155">
        <property type="entry name" value="UPF0113_PUA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17833">
        <property type="entry name" value="pre-PUA_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03657">
        <property type="entry name" value="UPF0113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017190">
        <property type="entry name" value="Rbsml_synth_fac_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88802">
        <property type="entry name" value="Pre-PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUA" evidence="8">
        <location>
            <begin position="129"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY22539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGZ35241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="214" mass="24105" checksum="B6BEEA7ACEF775AA" modified="2018-09-12" version="1">MTLGPLCLVRPLTEAETKTLFSKLANYIGSNLVHLVDTPDDPHVFRLHRSRVYYVREEIIRQAISVPRANLISLGICLGKFSKTDKFRLHVTALDLLGRYAKNKVRARSSCSLGVRCRVISRRLVLSLVQIWIKANGEMPFLYGNHVVKAHLGKITEDTPEHQGVVVYSMTDIPLGFGVTARSTIDTRKLDPTAIIVFNQADVGEYLREEDTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MVL2</accession>
    <name>A0A2X0MVL2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative lipoate-protein ligase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C004g02682</name>
        <name evidence="6" type="ORF">BQ5605_C004G02682</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LplA family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY66513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MVL2"/>
    <dbReference type="STRING" id="796604.A0A2X0MVL2"/>
    <dbReference type="UniPathway" id="UPA00537">
        <property type="reaction ID" value="UER00595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017118">
        <property type="term" value="F:lipoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16443">
        <property type="entry name" value="LplA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.50">
        <property type="entry name" value="CO dehydrogenase flavoprotein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004562">
        <property type="entry name" value="LipoylTrfase_LipoateP_Ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00545">
        <property type="entry name" value="lipoyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561">
        <property type="entry name" value="LIPOATE-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561:SF3">
        <property type="entry name" value="LIPOYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="5">
        <location>
            <begin position="69"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY66513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="399" mass="45104" checksum="025B1C9AFEE658A3" modified="2018-09-12" version="1">MQPLLSQLVRSTKAVPACACTRLVTRSRSLSGTVSFQSESKAPLAIYVSKSHDPHFNLAYEDWLFRKTDPSIITLYMYRNTPSIIIGRNQNPWKEIDLHRLEQLGIPFVRRKSGGGTVYHDLGNTNYCVFVPRLEFERRTNAELVARALNNLGIEAYVNDRNDICVDSFKMSRSAFKLVNARAYHHGTMLIDAKLKDLKGLLENSRVGALRRTAFRKPPLTNGLDVHFSPIQDTLVTKGVASVPSPVKNLREFSSTIDHASFVRAVTKEFGRSHGDEGLKIHEVDESEVERNEYVRGVIDELQSWDWKYGQTPEFTHDVSGELPFGPLAYHITSRHALITSCTITTSPSNADYYRAAQTVREIVQDLRYGSLDGVENKIPQGLKGKRVKELLKWLRGVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MWW6</accession>
    <name>A0A2X0MWW6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">proline--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C001g00144</name>
        <name evidence="12" type="ORF">BQ5605_C001G00144</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="2"/>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY44338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MWW6"/>
    <dbReference type="STRING" id="796604.A0A2X0MWW6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.30.110.30:FF:000001">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
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    <dbReference type="FunFam" id="3.30.930.10:FF:000007">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
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        <property type="entry name" value="bifunctional glutamate/proline--tRNA ligase"/>
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        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
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        <property type="entry name" value="C-terminal domain of ProRS"/>
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        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
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            <begin position="256"/>
            <end position="496"/>
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            <begin position="136"/>
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    </evidence>
    <sequence length="716" mass="79292" checksum="20B121029363BC69" modified="2018-09-12" version="1">MDLTSLTSRLEALQLLSGEKKPAAAAASSGLQTYFFTPKSGSKHPSHADQDLKLVVVTLEPEQNLGPAKALATQVGLKDMRAIAAADLEKLLGRKREQASPLSVPPQLVASTLLITSSSLTSSSETFSVPSPIDPATTLSVSAEQVQQLIKKLEEEGAAVKAVDFQAKAAQAAAPASPAVKSTPARGGSTIAEKEAAALRGKKDLEGKSGVQLGLTIRKEQAVFGDWYSQTLIKGDMLDYYDISGCYILKPWSYGIWQTIQNFFDAGIKELGVQNAYFPMFVSSKVLEREKDHIEGFAPEVAWVTRAGQSDLEEPIAIRPTSETVMYPYYAKWIRSHRDLPLKLNQWNSVVRWEFKNPQPFLRTREFLWQEGHTAFLTKPEADTEVLQILDLYRRVYEELLAVPVIPGVKSEKEKFAGGLYTTTVEGFIPTTGRGIQGGTSHCLGQNFSKMFNISVEDPENKGDKLHVWQNSWGLSTRTIGVMVMVHGDDKGLVLPPRVAQLQVVIVPVGITAKTTDEERGQVYEACLSVEKELKAKGIKVRYDDREGYTPAFKYNDWELKGVPVRLELGPKDLKEKSVVAVRRDTGNKSKLVIKDLTQSIPDLLDTIHDDMLNKARGEFNDHITVIERWEQIVPTLNKNHVVVLPWCEIEACEDEIKKRSAQESVEGAEDEKAPSAGAKSLCIPYDQARFGDVKGKKCPQCGEEAKRWTLFGRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MX61</accession>
    <name>A0A2X0MX61_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C001g00234 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C001g00234</name>
        <name evidence="1" type="ORF">BQ5605_C001G00234</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY45017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MX61"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY45017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="148" mass="16146" checksum="5DB34B37B76F938A" modified="2018-09-12" version="1">MSKFAGRLWLSFRGSSVSRTRAGISPSTLPQHWVSSALPAVAAPVFAAYLCHLLPRLDLPSDTNTLPPSLLPCQTTTDSCPLRTPLLLNLPYWITTLATQRASVQGWSPFITCVTLSKQSVLFLSSSRPPLKINTATRLVPRYLAALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N0A0</accession>
    <name>A0A2X0N0A0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C009g05496 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C009g05496</name>
        <name evidence="8" type="ORF">BQ5605_C009G05496</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY81412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0N0A0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.430">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015661">
        <property type="entry name" value="Bub1/Mad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013212">
        <property type="entry name" value="Mad3/Bub1_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030:SF4">
        <property type="entry name" value="BUB1 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030">
        <property type="entry name" value="MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08311">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00777">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51489">
        <property type="entry name" value="BUB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0137">Centromere</keyword>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="3" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BUB1 N-terminal" evidence="7">
        <location>
            <begin position="101"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1175"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="66"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="244"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="426"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="606"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="669"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="929"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="985"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="428"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="465"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="625"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="669"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="947"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1045"/>
            <end position="1063"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY81412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1510" mass="164775" checksum="20DEAF4900FA896D" modified="2018-09-12" version="1">MATTASAPVDISTIEAAKENILPLASGRSASQLASLSSSTRSGLGSKLAQEHKKFDAQIAAIDYYENTGEWPPPPSSSSSSSSSPTSSVNSTPPIDSLKLSLEEVERMAEDPLDVHHQYARFVISNYPAGASAANKLVPLLEKSTRRFLQDERYRNDPRYLRLWNLYAKHIDCPEDCYKFLFAKGVGERLAMLYEEYAAVLEQAGRRTQADQVYSLGINRSAAPLDRLKKRYTEFTARMLIAPPVASPPRANPSTSTDPTINPHARPALSGRGFTAGAKENQSASSTNGASAFAIFRDTTPSSSSTLENSGGSEWKDLGTVASRKRENEMEAKGWKGETMPMGGEKAQTVAPIKLTVFRDADAPATLTSHLQDPTIDVFGRSMRGPSEAEQLRKNPFKNYSSADSHLSTIDPLDGLVVIAPPKPRVKASSISGSSSTSSTKVAAPSTASASNTSAAPSSSKTTKGKKEPAPKPTSEKVACDLRAIYPDSKSEFSFEELMMKKRGGKVMGWIGWEWAEAWSEEMMRRGDKSFERDLGTGYPRLYDLKTHAPLYDLLPRPVEATVVSPVQSPARLPSSDSTLQLSTITLADVPSTQSEPVRLVSSISLSPPVSRQVVTSSPTSVPLRDSSSTPDRSDSSSPVDTRRQPSPTINTREAQAMIDGLFAKTLNFNDRAQPRTNENSDSGSDSEPSTEDSDVENDRAAWADLPVSQLDLAMSQFTSQGATSQSSTVSEMEAPFVPFSQTASQTQDSLFGPSQFSQLEELREQSESSERVTSLGLMGYGGGDENEGIVVAKPRPMQLFRDALPTHQAGLNDRPIPMSFKPSRAPFGEKSALTFAIHKDEQPQGVFAAHDNGAIPSSQPDERVDESFEDFEAPLAQGFDTDDEGSVGSDRIGVSLGRRPAGVPNRYAPFIHAMTPITERTGEYTAFSSLSTSQRSRRDSAFPATVEEDEDETDSEPSTEDDEEEEEEGEVANQAFEGFLGGAAQPEEEDDSTSNSSRTTSSEDEEEQMAPSRQVSMAPSLFEVPVEAPQEWRRTSLVGKETNLPKTSSGRPSTENSYDASVNTSLPEGLALTGNRTGMTTGKVVDSTTRSSLVSTSSLAPIDPWSDAAIAQAVAAADPPILSHPNVRDRTTLSIKNLLQLQKAAKKREGKNKSKDRTGTFDEVWEFRLDDQTYPVRAKLGEGAFGSVFRVAMPTASDDDPDASFDYDAEETTMAVKIERPTNLWEFHILDRLHSRLDERVRRSVVAASRLDAYADESYLFLDVCTQGSLLDAVNNANELGIAPATGGVAQGVDEILAMFFVVELLRTLEGFHRAGFVHGDLKIDNCLVRLEDVPNPARNWSSRFDRTGAGAWNAKGLKLIDFGRTLDLSTYPEGQTFICSFQADQGDCLEMREREAWTFEPDYFGAAGIAFTLLFGKPIETRLVGGEGTKRQVIDQPFRRYHQVDLWTQMFEALLNPRLVKGLGGRLPITEEVGRIRGLMEDWLEMNSEKNGKSLKKMIKDIMKASLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N1Z6</accession>
    <name>A0A2X0N1Z6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C036g11467 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C036g11467</name>
        <name evidence="3" type="ORF">BQ5605_C036G11467</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000063">
        <property type="protein sequence ID" value="SGY95028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0N1Z6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1248"/>
            <end position="1533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="642"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1832"/>
            <end position="1851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1840"/>
            <end position="1851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY95028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2207" mass="245522" checksum="3F48306AC591CE97" modified="2018-09-12" version="1">MQTGDPGSAPGARAPPPPASAPTSLPIAGTKETQATQVAGRTATYAAATNSSVVSNETPAQQQDRLARLQALPGILAAIQAVPGNRADRFVQAIFATPDFPSTVATALKFSALNATRNIINPFANALEVSLSHKSTGRASATDKGELVACVRTLLSPNTPICFDTGVPLSGDLEAFMPRITGLQHSSTFRTGVLHHRITVGFVSAEARDAALASAPMLVWNSANARFAKAHPFHRNMLEMRINVGVVRPPSKEQIVAAFQSIVQQLSTKGHSCQLVQVLRVIHVDTAKAYAHTVGDFSAFIHFDDASLFQHPTTTLKEILPSRMDLPTRGLDVTAVRHDYEKEAPCARCHFAGHVERCPLMQAANRKEAEDLARHAVMRGAGMVGGGEQTGVGRAATTTTNNIRPTANNNNTSEVVAPSRALGTDQLESRNRFAGLEVEGGQEDDIEEEVAGKEGEEKEQVEEGDEDTGAKADDEDSDSDGNAGAGIDKAGGDNKDDDKDEQDDSSEGSERRGDDVMKDGAEEEDEEMETEVEEEVEQEQGVQDDSIMIIDDGQTTITTVSRESTPRSPSWPPLSPETLAKSLREGAEWDRANAEAAARVQAENEAIINAQLDAQEPLVRHQFAEWGQEDGQLRFINIRGTGSRSNKKMKRSQTVADLSDPSDDPVDVKRVLNRVKGRAGKEVAGQGKRVTRSMSAAAAMQVEGAKAKAEKGQHYRQEHVYIVYPIMIKHLITSWNVRRCMGIPEKRRDIYTYLSTFRASAILLQEHFIKPELWQCIKDEYEGKAFISKHCLTLIPADSPLIDAEILRTHSALDGRILVTSFRLRGNIRILEINNLYAPVDTKQRLTFFDKLHFHRTQSTHLRLLGGDLNDCPLPAIDRRNQGRHGHHWPILIGKLDSPYTDCIQFKHPLTPSFTRPNIVRKRPKSFSQLDYFLLQRTHQKRLVQASTIYDHPKDLSDHRPVSIVLVLSDERGDAAEPNNSLPTTSNQLHRINAATFKTAAFQGMLEGWLEGASGEEPVGELEVVLGNCEKEGRELARREHRERVERMAVLVGRVQDLEALPVMGDEETAEWTRTTEELRQAVNERARQLRIRAHVPEIATEERLSRPVHAKLAARSSDSKITALRLPNGELTHDIDVALDHTQAHFQRLYDLEPRDRDHVERLRDDFLAPIRAARTCDDPSSDPLFLGRLSEAHIELLQQPITEDEVVAAIATTHPGRSPGPSGVPYELYHTAPRAWAKALSRAFNAMTERGSLSPKQGQGLVRLLFKHQKIGADRAELSSYRPITLRECDYKLFTKVYVARLNHVLPDLLPPQQHGFVKGRRSADASFHLRLLIEELGARGTEFPDAALLSLDQSSAYDLVEHEWIFAIFDALGAPAAFQRVLRMLYSGDSTTARYIINGFLTPPVRLTCGLGQGDPASSSVWDVVFQPFLDALHRRGIALNLSLPTIHPYPQSRAITSLAFADDIVVAVAGSESLTLLDDLALDWRLATNGRLNTEKTVVLPIGCRWEAGDRPLVVKAEGESLEWIGLSFDPTGNTELANVNLVARLEAVLDSARDRGLTHHTRAFYVNRYAIPKILHILSADIPPLEVVKELDRILVDFVRGGKRRSCYGKDVVFTPRFKGGLGVMRMQDVVDSVAARVWDVLLGGSDAIWQGLARAAIVRAHPAPDFDLATDAWPCDYTPIRTDLHPRWQAVLKVPSTHNAQVKPRTLTLANLLALPIKLHTLHYLPGAPAVSRSPYDVDYAAFAIYAKVADLFRRELYPGGGFHLWTPPTDVVVSNSEYDQRSRPQREHIVAWYRHAINRLRFTPIAQPVAAVRINGPPRVRPTTPLESILPHPIDPPQRLPRPALPDQSTQYNLLSMDWPYTIRRVRRVLNAKAFTDTIGFRDSLQPDDLKGFWKGVNSKALTAREREVWFKLVRNFTPTRSLQFHQKHDDSPACLVCGAPKDDREHYFFDCVDSGNVWIAARSVLCDALGLDTIDNTHYTAVQRMTIEIFTGLILEMISSGRWGMQKWGTRMEGVGRRRIILEESFSSSDLRSFWKAVNSKALTAREREVWFKLILCFTPTRKLQHQQKHDTSPACLVCEAPVDDTDHYFFGCVDSRNVWIAARGVLCDALGCDTIEDAQYTTLQRLFGLPKLKAKLSEQEGAGWTIEIFTGMVLEMISSGRWRMQKHGTRMESVERRRVVLEERMKLRAGGARGGRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N3Y3</accession>
    <name>A0A2X0N3Y3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C030g10761 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C030g10761</name>
        <name evidence="1" type="ORF">BQ5605_C030G10761</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000069">
        <property type="protein sequence ID" value="SGZ08010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N3Y3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ08010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="189" mass="21895" checksum="5C979BADEBAD4159" modified="2018-09-12" version="1">MVSHYFFECAYSTSFWGGVLRILLDKLGIEDTDVDPSTFTPEQLTMGLPLLRGRGRTTLKWMWVWLACAIGFQRLHLLRWRVHQWFELDNVVAPPSLPSALRAFEQDFLSQAGFVPGARDWERFSFLDGSASQFRQMVCLFALVKIYGMAREERLVLLYWIAFCSTPAAQQPALKIQPREDIRRCRGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N5A9</accession>
    <name>A0A2X0N5A9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C029g10695 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C029g10695</name>
        <name evidence="2" type="ORF">BQ5605_C029G10695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ15719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N5A9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ15719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="310" mass="34488" checksum="4B1451CE06D1A53A" modified="2018-09-12" version="1">MNMTIAELLAFDVAPADASLHIELSKDEHTQYSTLSSARCPTSSCSTQGRPMESSDPTRGEAGVGVSNTEEGRSTAHSCVLKGLVQSMGPSRCEDMAGTTRSFRWTRGDQMDRALTTHEDPEEYGALAQRYPHFGSLDGGAVTTTTTSEIGSLVCFDLKRGMHSISCDQTAYGEEQSDNKPLQPRHARLVGFTLKCRRHRVIRPVNDYISFNLGPYLMLPGRAPNQHKRTCRAKICRPSEPAQMPPRKQGAQLQQKGSLTTKQRASQPSKEGLFEAWSHAQHQPKRRAPQATFNRPPRARKRSERVFEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N661</accession>
    <name>A0A2X0N661_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C008g05117 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C008g05117</name>
        <name evidence="3" type="ORF">BQ5605_C008G05117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N661"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016120972" evidence="2">
        <location>
            <begin position="19"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY79384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="123" mass="13584" checksum="05FD62536C8734F2" modified="2018-09-12" version="1">MVGYNFLILAALAMKSAASTVPRMSHCQKDCGMAVFESTDCTGWDKIRCICEDTMFTDRLVDCLSATPGCAKDIPSIKRQLCSKCRKAKIDGNDRPYVCKNSTQSTSVHKTHKNKKHGPNQGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NF14</accession>
    <name>A0A2X0NF14_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C025g09970 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C025g09970</name>
        <name evidence="7" type="ORF">BQ5605_C025G09970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000087">
        <property type="protein sequence ID" value="SGZ26836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0NF14"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010436">
        <property type="term" value="F:carotenoid dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016121">
        <property type="term" value="P:carotene catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF89">
        <property type="entry name" value="CAROTENOID 9,10(9',10')-CLEAVAGE DIOXYGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="732"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="845"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1273"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1462"/>
            <end position="1502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1521"/>
            <end position="1565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="747"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="757"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="782"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="806"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="861"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1273"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1541"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGZ26836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1565" mass="170911" checksum="68C78AED54AB265D" modified="2018-09-12" version="1">MAKHPYASGNYRPMHCERGLTTCEWQGHIPDELAGGMYIRNGSNPSIASGSSVKTEDFERAYHWFDGDGMLQGVYFPRRPVDAAKDPSGSAVAAPEFVNRYVLTDVLLATPADATAPILPSITTLLGPLKQLPALIASVSRAVILAALSFAAASAEAISHVSVANTSILYHDGRALAGCESGPLAWVLLPALETVGWWDLDGDDGEIGMREKHGALGWMKEWTTAHPKRDPVTGELILFHSTMLPPYLSYSVIPSTQNGKAQTPRILGAPVPISGPRMMHDCAASHTHTILLDIPLSLDPLNLLRGVPVVAYSPSIPARFGVLPRHSPENVRWYSAPSCIIFHTAFAYNQVDPVTRQESLNLVCCRLNSSRLVYAAGNIPTPSSQLQPGLEETCRLYYYSFVLSDVVLPQDLAPSHAFALSVLPFEFATVPLKHSMSSSRYVYGCSMRVGSFSAALGGAAKIDCIVKMDVQALISEGTDRRLHDEQAVDERTMTQILEDQRSGVSSHIKVFVMPPGHFAQESSFVSRASPRGEDDGFLLFYVVDESQLDPLTGEPMEHAKSELWIIDAWTMVDVIAKVQLPQRGDWFTEREIARQRQAPTLRQRPLATQNSKLGSVRETDHRLGWWGSQCQRLIEILAQIVQPKWGARASTLLFEKSEGALRGAPRSIAAVTSQLTPIFASPMKTPEIVWRVATQKLTTNGFEAFTPTTWGARARLRFFVDRRRRVDWFARPEGRWGQPPRFQPAMESPPPSPSSPSPSIMVHPSPEQSFSHSEPSFEHSSRSSPPSSPFSQRGQRRRLNPEDWSGDSSMDSVRYPNPTSQGVSSCDTSFEVILDSETPRWFLRGSTSHESSADADAERVSPTSTNASDLHPKNSSPSKTDQRPRASSVADMRLIGATSFAASSDAELQSAEGSAAAASRRASHDGVLLGHRRPSILPTLEAIPDDRISEAVAGATLDPQASMFEPSMPRDSSVARDDPIISDSIELIIERGKNEFGDLTKAARYGLAQRGFSTIPSLHGPLSLPYARCPSGIDAYLFSMDKEEDPWTFAFDQDTSESRRSGFQNLNAGRHAPVPLPGNARYLQGSHSAHSRVGSRVVSAPAEVGMGYTQPSGQSELPLVSRTVSQHYEVDGTEGALSGSVGISPAPALKRESTEFELWPTPGDMRSASSARDRLEAIIEPRKTEYHASSTRNHPPIDPHHDFYRMESTLDDYGAQRQETRQRLDGEPARPDFYVNPYESMGIIPPHIYLQQFGYQSVGAPWATINSLPSGTSWSSNQAPRGVPSSTAHLPPHLAPPSSTTPHFNSIYFSAQGSMVTLPPRGPADTLHLRLFQDPAIITASYVSDPPPERDPMYHHRGHSAYDAAIHSRNPHTPGRDFIPHDTLSPYAHSRPVAAAEYRRGSAESEFYGTAGYRLPTDSIRIPELATNNELIMSRRPSVPLQVASMRSAALTERRNSAAPAIPQIGEPRSHSIAKGNKLRLPSIVPGSTRPELDESRPSSTHCAADGTIILGANANLGNVPGLQASDPAPASIRTSTEKQRKSRSYRAGRGRKRSKARSSPSEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NHW3</accession>
    <name>A0A2X0NHW3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C045g12190 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C045g12190</name>
        <name evidence="4" type="ORF">BQ5605_C045G12190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000115">
        <property type="protein sequence ID" value="SGZ31513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NHW3"/>
    <dbReference type="STRING" id="796604.A0A2X0NHW3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031106">
        <property type="term" value="P:septin ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05992">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13246">
        <property type="entry name" value="PH_Scd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010481">
        <property type="entry name" value="Cdc24/Scd1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033511">
        <property type="entry name" value="Cdc24/Scd1_PH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053026">
        <property type="entry name" value="CDC42_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339:SF1">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06395">
        <property type="entry name" value="CDC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15411">
        <property type="entry name" value="PH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="251"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="3">
        <location>
            <begin position="889"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="645"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="693"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="810"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="757"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="822"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="836"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="850"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="874"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ31513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="985" mass="107097" checksum="9F50A96DCF59EB13" modified="2018-09-12" version="1">MTSLFQSAPLISTPSPSSIAVAHYGPASGAGAGVGDSGGGAIAANSTSRSHLLSQKQAQSTPITVETATSLMIADAPPIATNSALNKVASASSSLYQNCRVVLMRLRRVPGFAERFLDGPATAEAEAVLGLSSDPVSRSLHTLRLGSSLCFLFNALGLDHQLDINPKATISNLKACQRGTAHFIMACKQDLKWPDGQLFAIHELYGQDTNGVVKVIHTVNLLLDMLQIQGALLEPVAESDPVKPTSGPSDERTMIVREILDSERKYVQDLEVLQDYQRQVQANEVLSQDQVHALFLNLNTLADFQRRVLIGVEANASRPPEEQRFGNLFLQMEEHFSIYEPYCANLTCAQELAMAENAALSRLAHVLDPISELAPLLIKPVQRICKYPLLIGVRQDLDVKLSSRAVSHLTEIGIQWSAQSLLKNTPEESPYHGELKAGHAAIMRVTDRVNEMKRREENHKAVMDLRKRVEDWKGHDIDSFGELLLHDVFSVQKNDSEREYFVYLFERIILCCKEAAPVGRRSGRAGSVKGKTGSRKVPGLVLKGRIFVHNVTGTTATHRTSQNLLEIRWRGDVGEEAFTIKCRSEDVLKHWEKSVAKAVDEVVTRRRTNHLSASRRSEMSTTPSLSSFQGDGMSSSYAWHGSMLPSAGPSSSNCDDSEFISESGRSTPNSTMYAGLTRHASGSIRSIPIDAHGTVQRLRPNASDERIASPAKLTRSKFTSGTHTPAHGAGSPIEQVKPSNAMTKPSPPRRPVLARTRSASSPVESTKSILGDSLPQVLDSEWSVRGGDQHRATHPYASKPSPVEELTSAKVMGGHKPGGTNSGATLASQSSATSSNLKRFSSSSIGTDRSSATSSMSTSQPATNRHLPSPSSPQQFSAQHETYPSGRATSSTMFRFKINFGNCTFIVVASGRVSHRELLDKVLKKLRLCGHAIRDSTGLRLRYEDEDGDRILIGNDSDLQIALEDLEESTTTGQPTLVLSAKLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NS25</accession>
    <name>A0A2X0NS25_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C017g08318 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C017g08318</name>
        <name evidence="8" type="ORF">BQ5605_C017G08318</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY19796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NS25"/>
    <dbReference type="STRING" id="796604.A0A2X0NS25"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00266">
        <property type="entry name" value="MADS_SRF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1810.10:FF:000002">
        <property type="entry name" value="Serum response factor b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050142">
        <property type="entry name" value="MADS-box/MEF2_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033897">
        <property type="entry name" value="SRF-like_MADS-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48019">
        <property type="entry name" value="SERUM RESPONSE FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="7">
        <location>
            <begin position="115"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="197"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="276"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY19796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="767" mass="83579" checksum="3DEA1BB2B76FD426" modified="2018-09-12" version="1">MPPRSYPNNNDDDDDDDDDDDVDVTPSADGDSLILIASVEQSKFESPVPGSARDTRNLGLAKPTKFQSMIAQASGKGREDPGGEGDENDDDEEGGIGRTRKRKRRYANKRNATSTGRRKIDIEYIDDKAKRHVSFTKRKQGLMKKAFELSTLTGTNCLVLVVSESGLVYHYATPGFEGMVEHRRGKELIAASLNGELHSDDNIDNRNPVALTSKGSARKSNSNNAQPKQSRTSSAPTPIAGPSGSTSRTNRGRKPSASSPASPDVIMVDGSSSQNTAAAYTSNSQASTSSAAVERVRSSPADGLVDPASNGILGINHLFQPSSNGGPPSMVELVQQSLPPLAFPAHSESHTYALPPLDRPIVPGAQSTVQTPFERALGEHAPALALFRDQTERERTRNLVQGLNVASSMRPLTASMEAPAAIASSTSRYGSQDLMEAAKGWNGPFTVSVRRASDTIAETLLDAYNPGMGGGGEGGGGAQAEAEQALATAREMRTVSSFVVAHLATIRRNRSLLPATESTLKAFGVWVIKTGIESADYIDLAIKTFLTHTAISTSYLNYDQMRQHLLTWFDYLRDRQLITTDVHDALSSFHYLPREAKLAYGIKKWIEQVERMYSAQDLGGMRKVSGAFEVYRVRGNYVLLRGKNLKGNEDDLRSLSPFKVRLPREMTSLLEIEDELTLSITQIPASEKNHYKPHWTPGAFHAIETSSNADNVESDIEPEVYKEELDRLLASGSGRSDGEEEKIRFTREVIALLERAKELLKQGDLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-05-29" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NTW1</accession>
    <name>A0A2X0NTW1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C013g07127 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C013g07127</name>
        <name evidence="4" type="ORF">BQ5605_C013G07127</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY14844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NTW1"/>
    <dbReference type="STRING" id="796604.A0A2X0NTW1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013970">
        <property type="entry name" value="Rfa2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15114:SF1">
        <property type="entry name" value="REPLICATION PROTEIN A 14 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15114">
        <property type="entry name" value="REPLICATION PROTEIN A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08661">
        <property type="entry name" value="Rep_fac-A_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY14844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="109" mass="11703" checksum="7EC75A43A4B2FA8D" modified="2018-09-12" version="1">MERPTPRVNSVGLSQMGAGKVVRVVGKVISLDGDYAVLELSDGGQVRVKLSRSANLADTYVEVIGKIDGEGSMSELSSCNMGASIDMPLLEKVTELWAQYPNIFPSENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NWW4</accession>
    <name>A0A2X0NWW4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C015g08005 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C015g08005</name>
        <name evidence="1" type="ORF">BQ5605_C015G08005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY18200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NWW4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY18200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="245" mass="28208" checksum="C94361ECE2F1698D" modified="2018-09-12" version="1">MRRTGARGKHSTWRRRSKHSFRYGTSLMLATRYCAPPPAVSSILLSTTDHSVAAVRPTTPRPRGIRPKRDTSTWPEVLEDLGADVLVTQLVLNVGVWFVTWREAGYMDRVTDALRLVTSMLHTSESSVPLRIIGPSTPSVRPGVNCFEAYKRVTLKDHSMLAQRILKDFKETDPKLRVDFVDHFRLTDARPETSTDGRHWAMKSDFETVSKMRPLVGSADDAMLEWAWDVWRFRDQEEREIRWLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NXK1</accession>
    <name>A0A2X0NXK1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C014g07620 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C014g07620</name>
        <name evidence="2" type="ORF">BQ5605_C014G07620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY19332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NXK1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016132093" evidence="1">
        <location>
            <begin position="21"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY19332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="90" mass="10101" checksum="DA48B307456B43D4" modified="2018-09-12" version="1">MIKSLAFLLLVVFLARHARAAAITPGKARTLALPCNFLNCMEWNKKCRYECAVHIMPDCEMSTCNRWLRICSRICVGTIQQLPLDAGDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NZP7</accession>
    <name>A0A2X0NZP7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BQ5605_C016g08261 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C016g08261</name>
        <name evidence="11" type="ORF">BQ5605_C016G08261</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP31 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY21655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NZP7"/>
    <dbReference type="STRING" id="796604.A0A2X0NZP7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027105">
        <property type="entry name" value="Prp31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019175">
        <property type="entry name" value="Prp31_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09785">
        <property type="entry name" value="Prp31_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Nop" evidence="10">
        <location>
            <begin position="279"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="412"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="461"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="418"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY21655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="562" mass="60314" checksum="EAF8A9B565E0BA31" modified="2018-09-12" version="1">MTSLADELMNDLDTDSGGEDDQLDAVLGLNGHAGPSTSTSKLNGTTNEASNGAANDDDGQEDEAGDVLMDSTAVGDMMVPEGGVRPTLELNPDDVNAMQLGEVGELAKVTKLANGKTMKDVLSKIAYYREHPDPNLASDGDSQEYRLIVQANNLNVEVDNEMLIVHKVRALLTRDEALNFIKDHYLPRFPELDTLVSAPLPFCRVILALGNGPELRGDLTGLLTSGTVMAVTVTAATSRGQTLDDAEWKVVEGACAMMFQLDDAKRTILEYVESRISLLAPNISAIVGTQTATKVLGIAGGLQGLSRIPHSNIYVLGAVKRATTGFSTAAHSVDRLHTGFIYQCPLVQRTRAEDRMKAQRKVGAKVALACRVDLAGSHPTGQFGEEMLEKLEKEMERLARPAPSKIVKALPRPDEQKKARRGGKRARKAKEAYAQTELRKQQNRMKFGEAEEETGYADETVGMGMIGSSGSGRVRVTDGEARSKAKLSKSAKGRLASIKTSSSATSGLATSLAFTPVQGLELVDPSKLRTKTEEANANWFANDGAFTHVQKGGGFGKSQVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P0F6</accession>
    <name>A0A2X0P0F6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C001g00591 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C001g00591</name>
        <name evidence="9" type="ORF">BQ5605_C001G00591</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY47921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P0F6"/>
    <dbReference type="STRING" id="796604.A0A2X0P0F6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF4">
        <property type="entry name" value="ARGININE PERMEASE CAN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="51"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY47921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="553" mass="60583" checksum="F281DA5E0D1C12EF" modified="2018-09-12" version="1">MSSKEVDAEKAIAAEDVEKSEKTPAYTQVELHGLAGDTPDGTVHRDLKARHLQMIALGGTIGTGLFVGAGGALATGGPLGIWLGYSIMGLVVYSMMTALGEMCTLYPVSGAFTHYAARFVDPALGFALGWNYWYSYAITLPTEITAAALVIQFWEGGRNINVAVWISVFLVTIMSFNFLGVRAYGEAEFWFTVIKIITILGLILLGIIITAGGAGSPAIGFQFWRNPGPFQQENGIPGSWGQFLAFWTVFVQAAFSYLGTEIVALTAGEAENPRRNMPKAIRRVFYRILFFYVIGVFIMGLIVSPNDPGLLHNTGTAASPWVIAIRNAGIPVLPSIVNSVVLISAFSAGNSDLYAASRTLYGLACDGKAPAFFRKCTKNGLPIWCLIVTAAVGLLAYMNIGTSSATAFGYLSNISSITGLLTWGTIHLSFLRFYYGCKRQGIDRNTFPYVAPFQPYSSYFGITLVTLVIIFNGYTIFLHGNWNTTNFVISYITLVIFAVLFVFWKFWRRTHFVTLDLMDFQTGRRELDDIAESEAAKFKEPTTFGGKLWDAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P1C9</accession>
    <name>A0A2X0P1C9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BQ5605_C002g01219 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C002g01219</name>
        <name evidence="11" type="ORF">BQ5605_C002G01219</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY31277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P1C9"/>
    <dbReference type="STRING" id="796604.A0A2X0P1C9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010435">
        <property type="entry name" value="C5a/SBT2-like_Fn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF66">
        <property type="entry name" value="SERIN ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06280">
        <property type="entry name" value="fn3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="9">
        <location>
            <begin position="17"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="C5a peptidase/Subtilisin-like protease SBT2-like Fn3-like" evidence="10">
        <location>
            <begin position="462"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="8">
        <location>
            <begin position="665"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY31277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1240" mass="136198" checksum="A74FD93FDFB5880E" modified="2018-09-12" version="1">MTGLHKLRAKGLFGFSNVTVCVIDSGVDYRNEVLGGSFGPGSKIRVGYDFVGQGSKLPGPDPYSDCEFGFSGVAPGVSLGAYRVLKCHEDDALTDDIKAAILRAMDDKCDVITMSVASNDGTGSPNDVPGKLLLAELEKKGVVVVAASGNSAEAGRGIADSQYASAATTTISVGSVAVSKLPLAYELTFKTGGYSPLPYFWGAHRVEIADSLKVMLLDAPESPSAEASTSCGPSATASQGLSMILVVIRANQMSTRTLVAFAHEHGARVLALTAPSLADPLSTYFSLQIYDWGDPPGSTDLAGLDINVVGMNFDSHEKIVGYAKAHPTGLVVNFRSQRKLLDLDNDIDGSRVVQTSDDGPRYDLAKPAALVLAPGQPILSTAPRRWGGARAMGGTSMATPFIAGASALLLSHRSGLTPLKIRSLFTTTAVPGGGLIAIDRAYAGRTYFDPCLLGIGDSSSSNTEQEVIVTNENDRSVQNHFETELETAMTLVFYDHDAKVEDFPTTSINALPWTSPPRVVIEPSRISVASGQSVKVRITIDSPKFSLTVAKRFPFYSGYIHFKTVGDELGVYRLPFFGLAADYKEARLLDTTTRFAAGDWGVPGLRYPFVGIYITKKDWDDESSPGIILREPNEVATSYHAFGLVIFFSNSLLCAVGLGPKARQWYRATYTNQSASIFLNGWLSATFDILSGVRQGDPLAPSLFVLAIEGFACQIRLRVKGIDIAGLQNVRELLFADDACCALHNLSDLDHLNRAIELYERASASKLSNVKSFLYPLGAFRDRSIAPDLGTWRLSDSQFRYLGIQVGVEIAEDAGWEDVKASTIARIRSVPMYDLPYAAKCSIINIYCYTKILYYSRFLPAPKSVVKEIEEAAMLAIHGRASDGTQRRPKVSRSRLCTPLDHGGFGLIDLPRRLAIDHAKWVFQLRAPDGCFTRHLFDIRIRLQAPNEPTPFTLSRPAPNQHRCPWIWIWWAYFCHPPPKWDHAVRKTTKLLPARWVRYFEAWALVTTLNPPELSKSQNLEQWATHVLYFPAGHGIQLSVNPTLFRGPDGEVMTPSSFVNASKRHQVFIFPLIFPKGHQKVFDLPEQRWNAWWKALRKVRRVHSGAEDTGHLLSLESLHSGSQVASPTSPHPSNRSNSCVMCLSEAPECLVHLAVGCPFARRLWSALSPTPHPVFVDFVCPVVSRSERRLVELRVLFFHSIWKLCRHRRFSSDLLEPITETEFEGLRASIQKSKGRLVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P1M1</accession>
    <name>A0A2X0P1M1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C002g01359 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C002g01359</name>
        <name evidence="1" type="ORF">BQ5605_C002G01359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY32395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P1M1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY32395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="57" mass="5907" checksum="617E23C00A64D59E" modified="2018-09-12" version="1">MIRAVACFIGPSAALVSGESGSYVILMSSGGFPCLTTHAIASWYRCVMSQFGSGSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P1Y6</accession>
    <name>A0A2X0P1Y6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g04147 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g04147</name>
        <name evidence="2" type="ORF">BQ5605_C006G04147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY56574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P1Y6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY56574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="150" mass="17442" checksum="D960FABB991F2228" modified="2018-09-12" version="1">MGNPDSLDDDLVSRCSLRQLVLSNVKLRLEQLQILCQTHNLQGYSLRRSRARELFLRILLFSRTESCPAYESGYIFKRSTANDILVPRRHCVPRHTVYRHKTLESCQAELSKEICEREERSLTENATQNRRRTATNNDSRADDDTRLSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P490</accession>
    <name>A0A2X0P490_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g02440 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C003g02440</name>
        <name evidence="1" type="ORF">BQ5605_C003G02440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY40904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P490"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY40904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="147" mass="16485" checksum="26392C9A559D24FC" modified="2018-09-12" version="1">MMVVGAHMIGITLLVVSGVWGLHGSLVAMTLDSLIQQQQKAVLPTHAGSRAVLETHVPFWAFTALSTFPYQLLRLRSPPVGTAREAWVAKLPILIPPTILVYHQEVRTLFRLDQSIAIFPRRLGFHRLRYLFNNSYTTNVVLRLAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P4E9</accession>
    <name>A0A2X0P4E9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g02500 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C003g02500</name>
        <name evidence="1" type="ORF">BQ5605_C003G02500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY41355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P4E9"/>
    <dbReference type="STRING" id="796604.A0A2X0P4E9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY41355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="151" mass="16134" checksum="D37CE24A8E1B4CED" modified="2018-09-12" version="1">MAATVPCTDGNALTGNSTTVFNCQANYTLFDNQCEYGFPYALFPGYGLSKPFAAKQQPFGPFTPDHQNTELCAITHPKARVIFFIGFSFNPATCSGQNGPLDQDLARVTDTSGYVLLKGLCSDGLKSSFVSAKKAGPACKQVFISPNDTVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P6D6</accession>
    <name>A0A2X0P6D6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="16">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">BQ5605_C005g03433</name>
        <name evidence="18" type="ORF">BQ5605_C005G03433</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14 16">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="16"/>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY75586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P6D6"/>
    <dbReference type="STRING" id="796604.A0A2X0P6D6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02083">
        <property type="entry name" value="P-type_ATPase_SERCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000003">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000037">
        <property type="entry name" value="Calcium-transporting ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000014">
        <property type="entry name" value="Calcium-transporting ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000028">
        <property type="entry name" value="Calcium-transporting P-type ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000065">
        <property type="entry name" value="Sarcoplasmic/endoplasmic reticulum calcium ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005782">
        <property type="entry name" value="P-type_ATPase_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01116">
        <property type="entry name" value="ATPase-IIA1_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 16" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 16" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12 16" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="823"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="919"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="959"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="17">
        <location>
            <begin position="3"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="SGY75586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="991" mass="107249" checksum="0829CE08BD04CB30" modified="2018-09-12" version="1">MAPAYALSTQQVLQQYDITAASGLSSQQVLENRKAFGENVLPQEDPTPLWELILEQFKDQLVLILLASAAVSFVLAYFEESDDKATAYVEPIVILLILIANAVVGVVQETNAEKAIEALMKYSPDEAKVLRDGRSLKVMASELVPGDLISVAVGDKIPADARVISIASASFTMDQALLTGESHSVSKSLEVVKDLDAVKQDQINILFSGTTVVSGKATAVVIATGSNTAIGNIHTSITEQIAAKTPLKQKVDDFGNLLAKVISVICLLVWLVNVRNFSDPSHGGLAKGAIYYFKATIPEGLPVVITTCLALGTKKMAKKNAIVRSLPSVETLGCTNVICADKTGTLTTNQMSVCKVLVIDDAGAAKELSVEGSTFAPVGNVSTDDGATVTLELLKTSSLTRLAEISALCSDAKVAYNEDTKVHSGVGEPTETSLKVLVEKLQSPSRDFNATLASLPPIKRATAVNEYYESQFERLLTFEFSRDRKSMSVLVRHRSASTAALYVKGAPESVLERCSYIHSNTDGARQPMSSSLRAELSAKVEAYGALGLRTLALAMIDGVDTDTANYHTESSADYVKFEQNMTFVGLVGMLDPPRPEVRGAIAKCRSAGIRVIVITGDNKNTAETICRQIGVFRSDEDLHGKSYTGKEFDALAEDEQIQAVLHASLFSRTEPGHKLKIVELLQAQGLVCAMTGDGVNDAPALRRAAIGIAMGSGTDVAKLASDMVLADDNFASIESAIEEGRAIYENTKQFIRYLISSNIGEVVSIFLTVLLGMPEALIPVQLLWVNLVTDGLPATALGFNPPDSNIMRRPPRSSREPLVNGSLFLRYMVVGSYVGAATVYGYAWWFMYYSGGPQITFKQLTNFHSCSELFPQIGCDMFVNEMSKRATTVSLSILVVIEMFNAINSLAENESILSMPPWRNMYLVVAIFISMSLHFMILYVPFFSTLFVITPLNWDEWKAVLVISFPVILIDEAFKAASLWSTLPATKTKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P6K6</accession>
    <name>A0A2X0P6K6_9BASI</name>
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        <submittedName>
            <fullName evidence="2">BQ5605_C001g00616 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00616</name>
        <name evidence="2" type="ORF">BQ5605_C001G00616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY48123.1"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
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        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF10">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiolase C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY48123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="106" mass="10881" checksum="B27186BC755787F7" modified="2018-09-12" version="1">MGIGPAIAIPKALAKAGITREDVDLWEVNEAFASMLGYLIDTFGLPHDKVNIHGGAIALGHPLGCTGARQVATGLNAIKRTGGKILVTSMCIGLGMGAAGVWVNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P925</accession>
    <name>A0A2X0P925_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g04291 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g04291</name>
        <name evidence="2" type="ORF">BQ5605_C006G04291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY57632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P925"/>
    <dbReference type="STRING" id="796604.A0A2X0P925"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="597"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY57632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="771" mass="86434" checksum="A415630757EE348D" modified="2018-09-12" version="1">MDILPHTPPPLQPSSASPVGTEKGKRSDKTKRKKSTTVRRRRRKKVTSNKDTIENGATTSVGTEEEAKTKKKKRRRLWTKRVRKREPSLSPDSELFEKTFGFNFGIFRSPTKRRPKRQPSPPTSPSVQNSTRRRKEHSEKSIAGLHKSSSEPWTDIADGATAWPLDTETGGFEHNFKPNSAPDFEPDYDFGRDFGGGYSSGPEHSPFHPDGASQDQAPSSLKRSQIERNAKKQRNRRRNARAEAKTRASKRAELLQAYLLMKKKAKEVLRQSGFVPSPDDEGWCDACHERRVTRKVRVVDLFFAGMRELRYCPCYPEIQTLAAHGLLPTSSSSIRKREGITAFTFRTIEYLDTYWGVDPFGIYDMSEALILFWSSELSSEDPFNKKILEASQGPTVRQHLQAAMDEYRFMQQLQATLTAEFIGLSPRERLADVCPACFGPRIDEAGKSENDLDVIIAVDGNFQHRRFARATADPLKSRPALFLSPDKIRNEQALIDGSTEAGEQVPWCCWCRDECTANWKAADGGVTSASSNVVADTGLVAAVCRHDHCLRLCNLHQSGEKLVYPVSLLKWILEEVEVGETDCTTGPARTSDATNVGSSSGSGSHQSSSQDRSRVGVAYDIACNLSSHLRRLISSRYAQRNLLADHLPRLEFALSSMHAYAHKWSCQVDFDPRFLPSFGLTNAEGAERLWSQLRGMIPMNRSSSASHRLENINRRASAYNKQHLAELGSPKLTKLNSRLKNAIKLKAEANRVIAEVVNRSAEWTVATLLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P966</accession>
    <name>A0A2X0P966_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C009g05645 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C009g05645</name>
        <name evidence="3" type="ORF">BQ5605_C009G05645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY83615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P966"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="61"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="489"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="550"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="629"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="177"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="515"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="550"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="629"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY83615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="699" mass="76575" checksum="4023A24ECE193A07" modified="2018-09-12" version="1">MTLLRRGRDLRSLVLREQDELMFDLLSKHRRLRLFEQAVRREPLLENLSPRLVTHWFESRTLGEPSSSASTSSSSGGSSPLENADTSSQWQQAHHNSHQHLGSNLRYPHHSLPTTTVHYDSGVPVPWDRYSPTSAPSGLDPHRQPMQTKHPSHVMDPPVALKYSTDEMAIAQRVNWLLQLQQQDQALNAAANRQREQLEMRRRFELDQTRVLEQDFLSHGLNLRVHRVRIREWLRLNQPQCGEPLEVKLVPTAGGTIITTTVYNNDRYAMHLPLRSLVALSLGSDSITLQTCERPSFYVTRRATGQSQTSADFTTERSASIESQHVFGVVPSELIVVRAQLEQLACSLPLLRVLLFPKPISSVYQTQPQIGAARAGALAWAPSMASPHLATSKSSPALLGAAAGYAQQPVQGIDSMSSPGASARPAHQRSLSWTNRAAYEDDCDRAAAMDLTRLQAGARSIDPCLEHAGAELTNQALPLSFGTTSTLDVSHSCPVPLPTTPENPNNKLDDMEVASSLSISTPRSRESTQGSDPTWDMFASPWSSIAAPTQTISSRASPSPASQIINGQREATPRPSNATLGVIGDPISRPPSGGAGSKHSDANSPSFMWNPFEATHCFNIQDWNSHLGTDANQGSTTISAEGNGTEASSTSLEKSDPNVHSENANLLDYDPNTLHLFTTPAHSDLQLNFGLETSSSWPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PB98</accession>
    <name>A0A2X0PB98_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C004g02835 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C004g02835</name>
        <name evidence="6" type="ORF">BQ5605_C004G02835</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY67992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PB98"/>
    <dbReference type="STRING" id="796604.A0A2X0PB98"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF30">
        <property type="entry name" value="DUF636 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G03180)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="86"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY67992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="227" mass="25198" checksum="98095F466A802F51" modified="2018-09-12" version="1">MPCALLQPFQVDVKLSNVIAPHFKTPVHRREPTPPCQRCPDRTIVRNPARVLTFVLSTPPDCLREYEFYIVVAPLHIPYPSLSMPINASCYCEAVQFELDEDVSALSGILCHCRTCQKLANDRSYNIASSEDKLKVTKGTPKVFDDQKTDSGMPIKRSFCGDCGSALFSKPSSRPGAVFVKVGVLDEAAKVKPGAEIYVDSQLPLIDSQSEFNIKIKRFEGMMAKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PDZ6</accession>
    <name>A0A2X0PDZ6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C008g04978 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C008g04978</name>
        <name evidence="10" type="ORF">BQ5605_C008G04978</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM11 methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY78870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PDZ6"/>
    <dbReference type="STRING" id="796604.A0A2X0PDZ6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160102">
        <property type="term" value="F:tRNA (guanine(10)-N2)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RlmKL-like_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016691">
        <property type="entry name" value="TRMT11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059073">
        <property type="entry name" value="TRMT11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370">
        <property type="entry name" value="RNA METHYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370:SF3">
        <property type="entry name" value="TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25904">
        <property type="entry name" value="Tmrp11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017259">
        <property type="entry name" value="tRNA_mtfrase_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00507">
        <property type="entry name" value="N12N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51627">
        <property type="entry name" value="SAM_MT_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA (guanine(10)-N(2))-methyltransferase TRMT11 N-terminal" evidence="9">
        <location>
            <begin position="40"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA large subunit methyltransferase K/L-like methyltransferase" evidence="8">
        <location>
            <begin position="221"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY78870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="505" mass="57261" checksum="92FE46AB3EF2F4E9" modified="2018-09-12" version="1">MTEHSNRSSTACYRSVRLIAAAHPTNSQQKMRFLLVCSRDDLDEFRIPEIESIATLFKLPLRFEPDRPSSSSAALESPFVVIHLDNEDQARLLGSRSIGVKSIWQHWADAPTYEQLSDRLKTEDALWRHHAASPTTTWKFSVTGHGRSISQSAQRQVINTFSFMCFVGDIRLKDPDVEIGVFEEYASVKEAESIPTGGTVRDMRTICDTQRHMMDVFDVKKRSYIGTTTMESEVSLLMANQALASPGKFIHDPFAGTGSMLLTASAFGALTFGSDIDGRQMRGKNSKNVYTNAEQYGFRNRIVDCCSFDLTQHPLRTGELFDAIMTDPPYGVRAGAKRLGRKPNHREVLPTLVPGRESEGFHHQLPEYVPPSVPWEMTQVIQTLLTYSLYLLKPGGRLVFFLPTNNEEYQDVDVPSVPGLKLISNSSQNFGKWARRLITMEKSRGKEWREVIEGIDRGIWRENMFDWFKERQTHSEGIDGEGSTRKPGHAEFARRYFERFESAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PFA1</accession>
    <name>A0A2X0PFA1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C009g05409 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C009g05409</name>
        <name evidence="8" type="ORF">BQ5605_C009G05409</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY80935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PFA1"/>
    <dbReference type="STRING" id="796604.A0A2X0PFA1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="7">
        <location>
            <begin position="213"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="362"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY80935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="392" mass="44376" checksum="7A607A451F013DA7" modified="2018-09-12" version="1">MNRTPNSTSTMVAYWVSSLASSFTPIPSPGRAFALAASGPLASPSSSSASPSLNVSYPTPPYAASFYHLHRERVWSPISDSVAAVAAPFVVYWAMSALFMFIDALDLRSFDRYRIHNPEEAKTKNRVGKVQVLRAVLIQQVLQTALGLYWLADFDPTHGPFRDHAASIATYAERMARVVRFLVMSSSPVKPTSPIIADAAHWLYWWGVPIVQFVCAAFVLDGWQYVWHRYFHTNKFLYRHVHSIHHRLYVPYAFGALYNHPLEGFLLDSLGALIAENVVGLTTRQAILFFALSTAKTVDDHCGYSLPFDPFQLFFANNADYHDLHHQIAGLKYNFSQPYFIHFDWLLGTRITREDFEAKKNRRLHPSNKVNGPNEIDAQPTSKRNGMALKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PFQ6</accession>
    <name>A0A2X0PFQ6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C009g05619 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C009g05619</name>
        <name evidence="8" type="ORF">BQ5605_C009G05619</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SWD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY83120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PFQ6"/>
    <dbReference type="STRING" id="796604.A0A2X0PFQ6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037867">
        <property type="entry name" value="Swd2/WDR82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861">
        <property type="entry name" value="WD40 REPEAT PROTEIN SWD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="131"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="302"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY83120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="401" mass="44245" checksum="7980953FBA33C9CC" modified="2018-09-12" version="1">MTSVQPKASTSSHVGSSSSSSSSSTIALTPDVMVSLKPSKVFRKHIEVDKQYTSLSFDDKGEFLVTAAEDETMQIFNVRTGKHKNQHYSKKYGVHLARFTHKNTNVIHASTKGSDDIRYLSLHDNNYIRYFKGHTKKVVSLEMSPVEDHFISGATDDTVQLWDLRAQKAQGKLHIAGHPCVAFDPTGVIFVVALNLRSTLLFFDKRDYDKQPFLHVNLDDQELSKISFPPRVPIYTSIKFSNDGNKLLVGTSGDVHYVLDAFTGSTLARLETGDKSGLERASVAPFERPLGDPVAGLSSEEVSWTPDGRFVLAGSIDGKIYIWDASHIKPSSSDVEDADQETVTLQPLHVDEGHLDGPSRCLLWNNRAAMFASAGDDLAFWLPDLEGRKAGAKGTEDVEMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PGG5</accession>
    <name>A0A2X0PGG5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C036g11511 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C036g11511</name>
        <name evidence="2" type="ORF">BQ5605_C036G11511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000063">
        <property type="protein sequence ID" value="SGY95722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PGG5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY95722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="552" mass="61669" checksum="DFD20EAB4E7E377F" modified="2018-09-12" version="1">MYQHTVVSAAPACGVGVPIRSHVQALWQRLARLSLSFPLTFPILFYSASSFAHCAAPHRERMDLTDRSPPWTCAAPHSSRPAARLSSSSRSDQQNQLPAPHPTTTSSCAKARKGERAGLESRSNPSGPTFSQGKVQHNPECRQLREGSDSEAIALRENARSYNNALSLTLLAAHFDQTRLGILGPRIPVVNQRSSLCSNVADRPSRHRHSTWTQRRRQSHTKAYFDQARVRLAQAGDTAKEWVLRLCLPPGRDRRTHNLPPPSTEMTMLICDSDTNTGDRGPQELIVQVRSHRCPDGRPKYQVVSSLHPSAMPLRYPTLFAAEESSSHLNTPLYGFHQAGPPIARNREQIDNGVQLREVLPVSVWMTNEEDKDRDDEDEDREEGDEEDGDGERQRSSKGVEVASLAFTILCALLAKGDEYFSIPHCTHGPFLESTARHHAAIPGCDGVRCPTWKASAAHHDDVRPRLTGNQGCTGADKAWNRPDLIARVFEAKSGNKRHAGCFGDECKMNGFCFFAVFRVMCERHEIALEPHWFRVQTERIKRCNSQAKKDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PH99</accession>
    <name>A0A2X0PH99_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C050g12473 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C050g12473</name>
        <name evidence="2" type="ORF">BQ5605_C050G12473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000097">
        <property type="protein sequence ID" value="SGZ29675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PH99"/>
    <dbReference type="STRING" id="796604.A0A2X0PH99"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ29675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="119" mass="13199" checksum="F2A50545D2C62FF1" modified="2018-09-12" version="1">MLGKGLRRGKSLVPAPLLLEPIRSLDLADSALLSLDQESAYNLVDHDWIMSVFRAMGAPERFLGLLNVIYRSVSLLYIINGYLTEAVRMLCGLRQGDPVSCPIWNVCFQPYTSGPDDVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PIC6</accession>
    <name>A0A2X0PIC6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C030g10835 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C030g10835</name>
        <name evidence="2" type="ORF">BQ5605_C030G10835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000069">
        <property type="protein sequence ID" value="SGZ09027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PIC6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ09027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="374" mass="41934" checksum="4AB0D347DEE4367A" modified="2018-09-12" version="1">MQDNHRTDVSFAPSQIFISSRYVKLASFAARADFSDQVLKSTSSALDLGMLPAEALLSMRIYEHPKDWQDWNTPAYSHSGESTLHLGEAASASSFFAIAGAEADDEVRRQNRQLAEFCTSSDGHRYSRSSHTHPNDVQHPNDPEDGDYPELPKYNEGRIKMTNLMLDEYPREVVFDSWRSNGRSNVEYDSGGVWQGPCPELNIQCIKYSKRYCFGCVSLLRPMLRPILLWQASTSDKDISTKEGKSPGGGRSAGHYTGSATSRKAIGPNVERTSSQIQLCPISAYNGPMKHILCSASIIRAQRKDHPGEVFIFPQPSSSACLVRHRNKWNNCNVCVMPCPKHRGRATHGPDDRLHRQPTTPAVRFRDLSTIRQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PLA3</accession>
    <name>A0A2X0PLA3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C022g09496 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C022g09496</name>
        <name evidence="2" type="ORF">BQ5605_C022G09496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PLA3"/>
    <dbReference type="STRING" id="796604.A0A2X0PLA3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ22500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="99" mass="9675" checksum="67EF3E0B40773E77" modified="2018-09-12" version="1">MGGGGGGGNGGGDSRYSTPRDSPYVTPGHSRPASSHGFNSSAFNDRGYAAKKSLHDQEQGHGGWGKSTSGGGGSNGGNGGIGRSGASGSGGAGHDWRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PM35</accession>
    <name>A0A2X0PM35_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C024g09850 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C024g09850</name>
        <name evidence="3" type="ORF">BQ5605_C024G09850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ26170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PM35"/>
    <dbReference type="STRING" id="796604.A0A2X0PM35"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057402">
        <property type="entry name" value="AIM3_BBC1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25459">
        <property type="entry name" value="AIM3_BBC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BBC1/AIM3 cysteine proteinase-fold" evidence="2">
        <location>
            <begin position="376"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ26170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="588" mass="63417" checksum="C89DA203E54BC334" modified="2018-09-12" version="1">MAPTFASLKAKAADAAGDLKTKSSSKPVQYKPVTPWDPEASRAKPSATERFEQSTVLQRHAAIHRPPPPPKRIHAPTAAEQETAGPAQPPRLPYRASPPSSGAATPPVAPPSLPSRKPAFGAPTAGSAPPPPPPRNNSNSSTVSSSNTGRAVPAPPPNTAAPPYQHAVDHDLPRRGSPAAALGRNGFVRFSEYGTSEKEELFAMLDEASRASIRCGLPRLSSLQLGGNEASLPAKTDLTSDLRRAAISPPSPPSPPPNVDAATLARVRRTWPYDGTANQAESEAPSYPPPQSHSSSALALCHWIMYEPYETLWYNEASPRPPPLVQARGDMRYAGSWSSTGTSKTTIGLIIFGDASCCWWAMSFDTRNPSQVERQARYRPIPSPWSGEQLYAASETYSSEIVTFARQAYASGQPVARGECWDVAAEALKHVNQRPGMPEAFPSIGRTHGHLMYYGRVGKPGVWRGGDCYVRPGDVVEWRLVKICVANAPKGSFSTLGDPDHTAVIVEVGTPKLTPADGEEIDVTQLPDLTVVEQSQGRPPLLNTYNLSTMSTGEVWLYRPVPLVEYVGTEIKVEWPPQCQTWEIGQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PPM2</accession>
    <name>A0A2X0PPM2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C072g12886 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C072g12886</name>
        <name evidence="1" type="ORF">BQ5605_C072G12886</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000123">
        <property type="protein sequence ID" value="SGZ34294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PPM2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ34294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="112" mass="12392" checksum="77BD7FFBFFC88051" modified="2018-09-12" version="1">MGCRDGRLPTRALIASNAVLCSPVQPSSTCAPFRLPRCCRSGPLLDSLHFVGIHLDAFARDLVAEEEALGSEQFRLLWGHVQISSSQRVQDQSYSSFVFLQCVGENCRRAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LNG3</accession>
    <name>A0A2X0LNG3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C096g13092 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C096g13092</name>
        <name evidence="5" type="ORF">BQ5605_C096G13092</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000010">
        <property type="protein sequence ID" value="SGY11633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LNG3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="377"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="529"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="708"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="714"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY11633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1181" mass="128871" checksum="7A2CC0C61C2301E7" modified="2018-09-12" version="1">MSNPAISTRHATCATREAGRNGSTTSKPNARTDLEHANFQAIALLRRSVSLNIKKQIKDGFDHTPTDVLKMIKKAVAAGTVTDIFIKLQALLDAGPPPSGVDAFEKYQANTIELFNTLSGYNLTFDQVISIRLIHFGKDLLQGTQAESTPAHKPVAMVASLTATDRSSSTPSAPCRHCGGPHWNRKCPVKDKKSKASSAPSASLAAAPDISTLVDGPVRGYLTAAMSTLAKPSLILDSGATHHIVNDRACFTNFRKCKPAPLEGITGEAVNSIEGVGSAVVRSFDGSIGQLHHALFVPSAPVSLFSASRANAAGYDINLSRGKATVSVDGSICHTGEITNGLYHMHASLVDVTTLIEQPGQHGDHTSPFPPPSRRIVQPSPLDRVHMDLLAFDGAVSLGGAKYALVIVDDYTRYLWAIPMSHKSDTFCGLQVVACKGRALLVEKLLAVRSDNGGEFLSNEFSSFLEEQGITRQLSIPDTPQQNGVAERANRSITEGVRSMLHQSGLSHALWAEALATYVYVKNRSPHSANSGVTPHTRWHGSKPSAGHLRRAANSIPRGIPLVFVGYDLESKGYRLFDPATRQVFKSRSVTFFEDEFPARRGGASQQLTRPSQATTTTTTTTMTKSLYSLTSMPIRHPRPSGGFRLLYVSTHRGPRGSHPWVRARATPQLVTAPLASLRSTPSAFAFSLGKEVTELVADLEAAGIDHLEGGIDRSQNQRTRSRSPSTSSNYPPVPQRSYDLYQVVTSFRTKRDKAGKMVSLKNRIGHHIIQADVDKAYLHGVLEEEIYMRVPTGIEGYEGKCLRLHRSIYGLKQAGRVWNDTINATLASLGYRRLACDECIYRHEDAGGDHYIALYVDDLLFFGPDLGEIDRVLDQLDTLYGVKRLGPAEWVLGVQVVRHDDGGISLLQRQYLLDVLARFNMSDCNPCKSPMEANLQLSPEPDTDSADNAIYRSMIGSLMYAVVATRPDLAHSVGYLSRFVGKAGNTHLEAAKRVLRYIKGSLDLGIHYTRTSAPLLGYEGYSDSDWGSDIQTSRSTMGYLFKLAGGAISWSSRLQPRVACSSTEAEYLGLSHAAKEAVFLRSLLTELGLDTSSPLRLLGDNQGAIALTQNPVFHARTKHLRMLEHFVREHVRNGEISVTYIPTHDMVADIFTKPLPRVVFQRHCDAIGLRRISGQEQGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LQ71</accession>
    <name>A0A2X0LQ71_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C010g05990 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C010g05990</name>
        <name evidence="1" type="ORF">BQ5605_C010G05990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LQ71"/>
    <dbReference type="STRING" id="796604.A0A2X0LQ71"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY13848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="163" mass="18071" checksum="7A8A0CA0ED9431F5" modified="2018-09-12" version="1">MAQYTPVLFGPIQFAHPSAMPSLIPSTGWLGNVLRKRAGSFIGFIKSNAHSPKNVAKGRPISKPTLVQSSHDLLVAMRSPPAAGAPSELPPSYRQSWISFSRDESVSSRASQDTRLPQETDADDDILYITRVEIGEQLIAERKIVDLLEKDRVMDQEFRRLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LQB9</accession>
    <name>A0A2X0LQB9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C010g05993 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C010g05993</name>
        <name evidence="2" type="ORF">BQ5605_C010G05993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LQB9"/>
    <dbReference type="STRING" id="796604.A0A2X0LQB9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058353">
        <property type="entry name" value="DUF8040"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF259">
        <property type="entry name" value="OS08G0106900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26138">
        <property type="entry name" value="DUF8040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8040" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY13862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="163" mass="18737" checksum="969BE554805F0A51" modified="2018-09-12" version="1">MTPSCFSIFVKKVLLHTEIVPSNHVTVEEKLAMLLYWQRGAESYRKIDEVFQRSLDTIARHLPETLGLLVHSDLRKLYVFQPTADTPTSSVITDKPRFARYFGNCIGAIDGTHAPYKTQDILAAMTFELRSCYLQTRCEGSAHDQQAWDWARERDLLIPEGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LSI6</accession>
    <name>A0A2X0LSI6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C012g06858 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C012g06858</name>
        <name evidence="4" type="ORF">BQ5605_C012G06858</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LSI6"/>
    <dbReference type="STRING" id="796604.A0A2X0LSI6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003980">
        <property type="term" value="F:UDP-glucose:glycoprotein glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009448">
        <property type="entry name" value="UDP-g_GGtrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040693">
        <property type="entry name" value="UGGT_TRXL_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040525">
        <property type="entry name" value="UGGT_TRXL_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226">
        <property type="entry name" value="UDP-GLUCOSE GLYCOPROTEIN:GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226:SF0">
        <property type="entry name" value="UDP-GLUCOSE:GLYCOPROTEIN GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18400">
        <property type="entry name" value="Thioredoxin_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18403">
        <property type="entry name" value="Thioredoxin_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="2">
        <location>
            <begin position="100"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="UDP-glucose:glycoprotein glucosyltransferase thioredoxin-like" evidence="3">
        <location>
            <begin position="451"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="814"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY16365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="836" mass="92128" checksum="87D66D08E054F8CE" modified="2018-09-12" version="1">MRITACGLVVAVARLVAMFWYTILNECLGIEDPSAYYPFISWLTANRPETASLRDAKFNPDDEAPKLPPRSSEPNLLFTRQLSPLESWRTLESNRFRGRFLNERGEKELFHMAIANGQADGLLEEMYKAWEKREKLVPVAEGVERCESWIDVRGHRACSVKQFWDLVGPQQSKGDKPLEILATGDKLAPEPFDRLEPPMPDDSLPFFVLYGSTDDETFAKLFDELNRLAGGDDDEAEDAVRLQFTIRWKPDSRTSKAGDAALSAFGVKLSLKDVTSLDEEHRADIRRRAINTVLVHNRVELLASFVAQSPLVGPSLSGTSDAAAGGPISDDVYEESITINGLSLDIDHADPVDLIHFLRQERAFIADIVSLHPDLTFAHAREILIGSSVSPAEEVSGRSASNVIKPSKHHPLKVVNLVQAMHDLPSVFNEAAFLESVESDGNEVPEGQEAPPDKAATTTIYVITDLDSPQGLDIAQEALIYIDSTPEVRINFVHNPVAVDVAEHAFTFSNLLYLITESGNMREVFPAELLTWLAYEVTKDGMETPIPDIWDEENPMTPFVTLGADEADAEAAKEYWQAVQEFAARVGVEPGASAIVINGRVVALPGNKFSANQFQQIVDYEYEVRIGAVVAMVDETIPATIREDRVAVANLYNAASSIVASSLMPPGTPIRARASLPFASDYPRTVVQRLPQDVLWDIDAVLDPLSARSQRWVPLLQSLSQLEHTNLRLYPIAANSPAASTLYGVAFPRAPVFDDKTQEPLRPSVIFSDLAHDNVVSSVEIEKRGIVHIEGGKSLSGKTIKEIPEGRIELRAQKRAADGLAAEQASESSRTPRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LSU4</accession>
    <name>A0A2X0LSU4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C012g06968 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C012g06968</name>
        <name evidence="1" type="ORF">BQ5605_C012G06968</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LSU4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY16734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="68" mass="7906" checksum="7E45C934BE5352DE" modified="2018-09-12" version="1">MFLKQIKVYTLTIGDHASGKLHCTLASIRLTVYLTLFNGAAGRHVYFYGREWFCTLVSLVIWDRIKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LTJ5</accession>
    <name>A0A2X0LTJ5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C015g07893 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C015g07893</name>
        <name evidence="6" type="ORF">BQ5605_C015G07893</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LTJ5"/>
    <dbReference type="STRING" id="796604.A0A2X0LTJ5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF277">
        <property type="entry name" value="GLYOXYLATE REDUCTASE_HYDROXYPYRUVATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015996810" evidence="3">
        <location>
            <begin position="23"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="4">
        <location>
            <begin position="17"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="5">
        <location>
            <begin position="138"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY17795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="343" mass="36657" checksum="56384436DA052EC6" modified="2018-09-12" version="1">MRTCSPSLLTSRLLAFVITTASKDLKVVSTMSAGYDHVQVSALRSRSIKLGTTPDALTDATADIGAMLTLMATRRAGEAYRNVIEGKWPTMPWSPFLLCGSGLQGVSLRCLSAAKLSVELWADFSPFFRVVVGPFIANTPNQKTIGILGFGRIGQLTLKRLLGFSPTKALYTTSRPGLPPTQDYYSLLPPNLNSAAIEPAATIRNLAERSDILIVTCALTEQTKGLVGAEFLGWMKKGSYVINTARGPIVDNGALVRAVRSGHLAGAGLDVVDGEPNIGHGHELLKEDTIVVLPHIGSATVETRDRMGEDAVRNLFAALGIAKVEGDTDGNGWDGGWRNQVQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LTM6</accession>
    <name>A0A2X0LTM6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C011g06480 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C011g06480</name>
        <name evidence="1" type="ORF">BQ5605_C011G06480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LTM6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY12358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="219" mass="24432" checksum="FB2BDAA6CEA2320C" modified="2018-09-12" version="1">MSSSNSGTIDWRGRAEQTERALVLQPLESERDLACARRDVLQARVAALETANKSIRGRNEYLENRDRIKCYGGLSSHKPLANLLQHSLNRLLSLFSTTFRIADIKSLMSGASRCKLRQEAIKGHLHFMKLDNGKDDPEVNINTTALREVEIEAAHMAMAKIEQRSNGAITLLWPAVTTTITKLATSSIFKAGIAFGSQNENRVRIAVDIIELRYPALQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LTP2</accession>
    <name>A0A2X0LTP2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C011g06572 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C011g06572</name>
        <name evidence="1" type="ORF">BQ5605_C011G06572</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LTP2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY12654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="54" mass="6113" checksum="B1329DB8EA419E9E" modified="2018-09-12" version="1">MGSMVRLRPGLMNVGRIVGVPMNSTLSKKSERHEITLEPHWRPKLTSASYMDCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LTZ6</accession>
    <name>A0A2X0LTZ6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbamoyl phosphate synthase arginine-specific small chain</fullName>
            <ecNumber evidence="3">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Arginine-specific carbamoyl phosphate synthetase, glutamine chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">BQ5605_C010g06148</name>
        <name evidence="15" type="ORF">BQ5605_C010G06148</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CarA family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="3"/>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LTZ6"/>
    <dbReference type="STRING" id="796604.A0A2X0LTZ6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="entry name" value="Carbamoyl-phosphate synthase small subunit, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050472">
        <property type="entry name" value="Anth_synth/Amidotransfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009475">
        <property type="entry name" value="PRK12838.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418:SF7">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="Carbamoyl phosphate synthetase, small subunit N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbamoyl-phosphate synthase small subunit N-terminal" evidence="14">
        <location>
            <begin position="53"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SGY14342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="452" mass="49248" checksum="7A2D13B7CBB50FAA" modified="2018-09-12" version="1">MMLAAATRPSPLWRHAATARFSLRSLATHAQRPASATMTPTTGKSTNLFDPNRPASLHFKTGERFEGKAFGAPISRYGESVFSTSITSYTESMTDPSYRGQFIVFTTPLIGNYGVPNNASIQDPNGPPLLLESNGVQCAGVIVGNLAEKYSHYQAVESLHEWCDRHGVPGITGVDTRAITTLLRNRGSTLSKLSTGEGHEVVPAAADFWDPSIENLVDQVSTKEIYTLNPEGDVKIALLDFGAKANILRSLTRRGASVTVFPWNFDFNTVRDQFDGLFLSNGPGDPKHCMEAAVHVRKTINEWDKPVFGICMGHQIIGLAAGLDVYRMRFGNRGHNQPVLALASSGAIKAGRVYVTSQNREFSYQYALELVDPFPKGWEPFFLNANDASVEGIKSTEASGKRVWGVQFHPESAGGPLDTINMFTSFVDECRVLSKAGGQPSDISLTHPEAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LUM3</accession>
    <name>A0A2X0LUM3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Stress response protein NST1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C017g08397</name>
        <name evidence="9" type="ORF">BQ5605_C017G08397</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">May act as a negative regulator of salt tolerance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NST1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY19944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0LUM3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051195">
        <property type="entry name" value="Fungal_stress_NST1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025279">
        <property type="entry name" value="NST1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31780:SF10">
        <property type="entry name" value="LD36051P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31780">
        <property type="entry name" value="STRESS RESPONSE PROTEIN NST1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13945">
        <property type="entry name" value="NST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="162"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="284"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="354"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="620"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="840"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="932"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="284"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="301"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="373"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="426"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="627"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="694"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="720"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="747"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="782"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="848"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="932"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="959"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1090"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1134"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1155"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1185"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1213"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1243"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1275"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1326"/>
            <end position="1348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU049441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY19944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1536" mass="166967" checksum="D80D58D2412E9A8A" modified="2018-09-12" version="1">MSGTRPPGAFPIAAPAPSSTPSSTKNKKKKAKAKSKKQLQEAQDPTSQQLSATRQYDDDLDDDLDDDDLPPLENVDHQHLHPGQQQHQHPHQHPGASLNPRDAHAVPNQGHHNAHIANAATAYAAYGQPHPGATPSDLLSTASDLYRQIEAAASLASSHPSFAAAAFPPPPGSNNHNNNGANTNSNGQNNQLNGIPTDGAYWTSLPQHLRQFIRSALPNGQPLPNGSLPPNVNGTLAALSSVVTGVNGQSLPPLTHEQLSSAAQQLAQVVNSNWGQLGLGPMPGVGGGAGNGQNGNGQNGNRGATTTTTTTANGATISLGAFPVSMPTREQMEHALGQLGNLGQLGAFGADVLNNPMAQQPQPYPTHHHHHPQQQQQQLQHQQPQPQQQHHHHHHHHDDPPHLDETEDEDVGLGAGDPNGTTTTSSKKKKKKKKKTGVAAAVHNIADATGGDVDELVRRETDVVDHAEEYRLAAARYPNYQVPTMPPLPALRGTIAPKPAPPAAVNPGRTTAPLANLNNSNKQARFTAGTTPSIAPQAGPSSERERIRDFWLGLKENERRALVKVEKEAVLRKMKEQQRSGCSCAVCGRKRSAIEDELEQLYDTYYDELESYALHQQRYQTSAPGTISPPPGPGPFPGSVDVAASTPAVPAQVARRTGAIVKPTRDHKNVRPAAKKKPPPPTAPNATNPHHQNHHDGPAHGEPGHTHSPSCPHHPHNHHGPTNPTTPATAQAKAKGAAVEHDHHDEEEGDEEEEEDEEEYDEDEYDDEEEDEEYDDDDDLPRDDLPKKVNKKNPDADFFGFGSSLTVKGGILTVADDLLKNDGHKFLEMMEQLADKRIQRERDATMLIDDEDDDPSDEEEDDDDDDEEDDEDDEGDDEDDDEVMTEAERMEEGRRMFQIFAARMFEQRVLTAYREKLADERQNQLLREFEAEQRQAEEAQARKAKENQKKKDKKKDQKQKKEEERLRKEAEREAAEKAAREAEEARIEEERRRSEEARQKREEERRKKDEERLKREERARQLKEEERRLREEKARLVKEARLAAEREVKEKKAREAAEKKEREEREEKARLVREAKEAEAVRERQRVAQEAKAASQAAARAKQAQQQRQATAPAAAAAQAAAASRFKSPNATRAAPGSPSKAPNGPGAPKAPSLSAPTQQQPMRSSNAAPGQMPTQRQPSISSMPSSLQQHLQQQHQQPQHGSPMLSQQQPTPLQQRIPHQQPQQQQQPQQSQQAMPPFGQRLPSTVPQQVPNGIPPAPGSSRLFSPTPIGPSPQLFGGLHGQQQQPSMVGGGFISPPPQQHPNLLVSPAALGRNAAIGPAPLSAGGSNMSSIVAPSTRPNGMPSLSQPAPIAPPSLSNAASPRPLHVGPIGGVIGRPGSSVSGQRSLSPPPRVFGSSALLEDDEIVVPPPRGASNVQPPPGPPGSAVPGAEWSSPFSTGIWGAPAMPSPMITPDRHSIVRDRARLTYFRLFEKYGNAVIPINEIYREVVAGWPDSGSIDVPELIESMAVEGNIVNGGGTFLMDLQNGEPCAQYVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LW70</accession>
    <name>A0A2X0LW70_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C012g06983 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C012g06983</name>
        <name evidence="2" type="ORF">BQ5605_C012G06983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LW70"/>
    <dbReference type="STRING" id="796604.A0A2X0LW70"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY16769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="636" mass="71951" checksum="1424B1CEDDDB05D5" modified="2018-09-12" version="1">MTLSNDAVVVPLLRVEDRDDSRYDVDLDLDVDHKGEEDASQAIEDRFQPPYLRSGKGGMTSYTSPVGQHFKTIRNVHKGLPVIVVMTVIVFIVMTTIILVVRRDRDVATVLSRLHEWELSGEAGSGVEQAQGLDWSEEAEMWRNYKREFQEPHESLTRMVTALTKVRLEHRPKEEVSIREWLLSTRPLSQTGAPVGLSQSSPVPARIREGPAMVRTGAGPGSYIKGSRKKWESLRDEWQTGRPHSQCRNTSWMADYAKLHHEIVTGARPTKVLECICRERHGCGGISDRLLGIFTSLLYAILTNRALLITWDVLPFEVFFDAVRIDWAQPYMPISKRSIHPGLPVLKRQWFTIINAEVQKIVAPPMSNMEYYLSVELFAEKRDDPPWLQVSTNRGGVITSFDYSAVKPALLERGFDRTSAYSCMADFLFRPKRESMRFITEYDSVFSLPTVFSIAIQIRTGDSSMTNSGIDTVNTVKRHQQFFDCAAKLAERYARNDQRVVYYLVTDSPTLEAAALRQFPDRLVVTGLTQGHPEFVYNVTNLAKVADYTTNALVESMLIGKTDYQIITDTSGFGKVPVLIRGVEGTTISLPRARRRAIDCANTDAWVPRNLEARSLMWAQADEQVSSHLVTIQIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LXB5</accession>
    <name>A0A2X0LXB5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C015g07978 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C015g07978</name>
        <name evidence="4" type="ORF">BQ5605_C015G07978</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palA/RIM20 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY18091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LXB5"/>
    <dbReference type="STRING" id="796604.A0A2X0LXB5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF39">
        <property type="entry name" value="PROGRAMMED CELL DEATH 6-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="3">
        <location>
            <begin position="1"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="729"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="733"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="754"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY18091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="784" mass="85496" checksum="BA376A84FDC487B4" modified="2018-09-12" version="1">MVTKLDSASVDADTLVQLSAYYAQLSFVITKLPISLVEFHWYPLFASSTSAPVVGAFDSVASVPIASLHFERVAVLYNIAAIHSILATATKRIDEAAMKSSIAGFQNAAGVLSHLLTLLPLLADEDDPEQDPMSPDFTPESIESLRDLCLAQAQEVFWQNGVLSNNKNTNGQCRAGRLKNGTISKLAVQVSLHYSSALASANAAKTKLKETQWTGTWAFPDSLLSYMSIKTGHFNAVAQYRKSIDDLGSNRYGDEIGRLEVADAAVKKASTVSKRGVADPVVRDLKSLQTVLTDNLARATKDNDLIYLSTPTPLSSLPPITPAAMARATTAAEIVSPLDHLQIGRLGKPLFEGLVPWQVHAAVKVYEDRRDTFIKDEVLVKKGALDALSTRTLQELNLPAAIDAVLQPTALPASVLDQSREVKTEGGTEKLRSLMQDVRRVARVNQKLLNKAIALLSQESLEDGQLQAQYGAGAAHRVGSGEAQVALKTRADNLGGVMAAAGQSDQLVRSKFGEWETKLELLCGDEAQLDEFVPQVGASLTSGIKSTQSTTIRRLRSLIDDLHELRSARQSIIDDSRRFVDADTSVRSKIERAANSFLKKGASLSMSMFEGVFENELAKFDGLKQAMGQNGARTEDLVGDVKIAHASFVDSRRSDPALARRTQALEDLNGAYHKYREILTNLQEGLGFYTDLARLLTELRDSVKEFTQIRSDEARHIEQELRAHMMNLSMQSETKDEPVEEPRRRISPRKKTVPKATPSSPAPAAGVAELHGKAWDPSMGIRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LXC0</accession>
    <name>A0A2X0LXC0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C015g07988 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C015g07988</name>
        <name evidence="2" type="ORF">BQ5605_C015G07988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY18141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LXC0"/>
    <dbReference type="STRING" id="796604.A0A2X0LXC0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039254">
        <property type="entry name" value="Rds1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38705">
        <property type="entry name" value="PROTEIN RDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38705:SF1">
        <property type="entry name" value="PROTEIN RDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13668">
        <property type="entry name" value="Ferritin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015921284" evidence="1">
        <location>
            <begin position="19"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY18141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="416" mass="46126" checksum="ED9CB21747ADD427" modified="2018-09-12" version="1">MKLEVPFQLLSLATLVFASPLPHNDGSVGVHSEQTRDPNLRDPIFVSVPEPVKNNPPLQGNPAVNGTNTTFSAPFTPAGGLLSQNPKYRVKSNFDYQSLSVGLHQELIELDLFQDALSRFSVDEWEAAGITAEDRFLIEFMADQEVGHATALTNMVGPERAVKQCVYRYPYKTVREFILFSHLLTRWGESGTLGFLPHLDNRNTAQIVLQAITTESRQEMIFRQFQGLFPMPMWFGKLLLLSMWRSQTTSWTLLQRYIKSCPANNPTIQFQIFPDLLITNAPNLLGHPPAITRNTSGVTYPSRVIKFEWEAPGKVTGYDDKYRTATTAGPPKFAAFVSQLNVTYTDLVDIDLAKRTAATKQLGALVFPGANGRPGNSQVNETVFVVLTDSKPFLTPGNITLINPHVVAGPALYQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LY23</accession>
    <name>A0A2X0LY23_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C014g07633</name>
        <name evidence="13" type="ORF">BQ5605_C014G07633</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Peripheral membrane protein</topology>
            <orientation evidence="1 11">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY19385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LY23"/>
    <dbReference type="STRING" id="796604.A0A2X0LY23"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050673">
        <property type="entry name" value="Mito_inner_translocase_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13172">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="12">
        <location>
            <begin position="16"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGY19385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="87" mass="9867" checksum="DBFCED89A692CD11" modified="2018-09-12" version="1">MDASAMNPATAQAFEAMMQQKQMKDFMNLYTNLVERCFTSCCNDFTSKALSSKEEACVSTCADKFLKHSERVGLRFSEMNAQMMAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LY90</accession>
    <name>A0A2X0LY90_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C014g07684 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C014g07684</name>
        <name evidence="3" type="ORF">BQ5605_C014G07684</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY19560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LY90"/>
    <dbReference type="STRING" id="796604.A0A2X0LY90"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="639"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="770"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="669"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="718"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY19560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="793" mass="86252" checksum="A54CB39D5B0A3D15" modified="2018-09-12" version="1">MNAVLSGSQWLRRSGSNKRAGAGSPGNAQSGTQSTLPPPPPAAQMRRTNPESPPASDSRSFEEPLWPTYEPPMLQLQTQRPSSAISDTASSTNNWTLDLGLSTPARARKSSSNSNGRAQLLANATDHAKTSFLALVDETQPGTSYSHELKHKLIARRTSKESSAGGSDFSHAHVFEASESHELPLRNETPHSHHTFGGSSGSGGIEVDRRHGATLGQHGRRASSPSIVAASSHYASNASSRSEAESLPAGTPEPVRGLDSVASECSVGLLSIASGLSRAPSGRAGTFDAGSFEWRASHSPRSRTTSRPTAENGAISSAEACSPLQSEHDSSLQHKDDITQRLPGEKKPRPRVESMPDPGVLHSSSPSRGRHRHVSLPAKASRARARSEGPPRIRVRSGTPLDMQMSDVAQANSDPFKESCRDQPQDERLWAVYPSSRAALGYSSSATLLCARESTHSILTFITASPRLSSTFLIEPNRDPFSDAFSSSSSSTVHVPWPEIDDSRQKTACEHFEEESVWIPLPIRPVHKSLPSSHRPVSASFLSAPPRELRRNWRNEQREKRRQSAHDSRREQPLEVPSTLHEVWAAAEQSSPIVQEPFALQDFQIANMPEFEMTPSLQSSRVGWIGRSISLGRLALVPLGGWCFVFGFICPPLWWVGALYPRRRTPLPPRRLGTSPHYSGGPISEWPDTRPGARKPLYDQRSRGGWLSSGLSRCIEGTEKDDLPQRRGRSSKPTSSRGIEGGPAAIARSAAMEREAAPWEWRRRNRVMSLISAPLLSAIIAATIWACVTASVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-05-29" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M0P7</accession>
    <name>A0A2X0M0P7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C019g08894 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C019g08894</name>
        <name evidence="2" type="ORF">BQ5605_C019G08894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY23088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M0P7"/>
    <dbReference type="STRING" id="796604.A0A2X0M0P7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.20">
        <property type="entry name" value="DHHA2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1640.10">
        <property type="entry name" value="inorganic pyrophosphatase (n-terminal core)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004097">
        <property type="entry name" value="DHHA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038222">
        <property type="entry name" value="DHHA2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112">
        <property type="entry name" value="BNIP - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112:SF39">
        <property type="entry name" value="EG:152A3.5 PROTEIN (FBGN0003116_PN PROTEIN)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02833">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01131">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHHA2" evidence="1">
        <location>
            <begin position="265"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY23088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="438" mass="47588" checksum="42DEC8D5DB35F50A" modified="2018-09-12" version="1">MPKSSVPATPPLLDFLTTSKQAFLDSLHQSGADLSEWTITVGNQAGDLDSLVSSIAFAYFLHIITPPKSLSVPLIMTARSDLYLRPENQFALEQANVPAEALLCIDDIPDPAALAARGANFALDDHNVLLPVFRSESKTPSTSGKPSWDTSVTAIIDHHADEGKHTSAEPRLIEPVGSCTSLVLSYFSPLLPPEYAVSVPTPLADLLLSTIAIDTSLKPSTNGGKATPKDLAAVQFLLPLSSFRSGSAAPSAVMGPSMTALIARHQVLMKKKIDISSMSGRDLLRRDYKEYQESGWKYGLSTVPLGLKAWLEKDKALGRQGWQGIEQDLLGWMKERNLSFAGILTSFSEINEENPEGKAVHAREIVLYVGGEGAKVERLREVLFTGLQEDQVLKVEKWKGGAVDGLKDERGWRVWSQGNARATRKQVAPVIKGLLARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M0X5</accession>
    <name>A0A2X0M0X5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g02188 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g02188</name>
        <name evidence="2" type="ORF">BQ5605_C003G02188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M0X5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY39276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="489" mass="51430" checksum="EF524F15185C0CB9" modified="2018-09-12" version="1">MSITFDTTSSTTRLAGPTSPMTRRRRSSFGGGTPTASTDICVQQALTSDEFVQRRKRRGGASALEHQSSDSALARQPLLNRKSIAIPPPKPNVGSSRDLSYGGKSPDANGSPALLLCSPSSASTIKASMFPRAAPAHDGSASERTGAKGPKRQPASRSFGSLQRPRSRPRSPRATKCGSDSSSIAPPSPSSSPSPSPSVLSRSGFPQQIHSDVHVPQRSISASSCPAPRGATLSLGPSTPIPLTSSILAEGQVELSTNLVAVEVLADLQCGRSVTSSECGDRDRERDHDFGSDFFVYDCTAPLSIPDVPPTDPDFAAKAGASLPSPRSPTYAGLVPLHPSGRSSTIRNHTAPLPVSDLDGMRAIDELRRCASASPMSTSPPHQGIPLSSLDKTSWDGGRVLASGQMSRSSSISRSSRNARFTSGEEKRLRHESEASSAQTTSPDGSKVLLKRPPLHTYTSFESAFDVAPPPSPPASPKGPNKGWPWQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M116</accession>
    <name>A0A2X0M116_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g02238 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C003g02238</name>
        <name evidence="1" type="ORF">BQ5605_C003G02238</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M116"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY39576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="277" mass="29368" checksum="EAA8EDBEA9BB1929" modified="2018-09-12" version="1">MAFSTSQHFDHDASWASFLEPSAFAEEFDTDPFASASSPGASSSSSLASAYDYSPMLPSRLLSSVSSLDSPAWSDASEPTTPPASASNLAPEVCLVTYDPSSFGDRSATWSSSPAQALALKAAKILDAALTKKQKPQLVTPVVVPSPLTSRRVESGSLFSYSSLEHEARQLASRLFTSSTYTGGKVPVASSSRLYLSRAHYLEKKRKCVSSLPCSGAAVAAEIAAAPMPRLKSRKGGRPSSEMSQWLQALHDAEVRASLAISKRKSPTPTSLKLPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M134</accession>
    <name>A0A2X0M134_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C087g13025 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">BQ5605_C120g13288 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C120g13288</name>
        <name evidence="4" type="synonym">BQ5605_C087g13025</name>
        <name evidence="4" type="ORF">BQ5605_C087G13025</name>
        <name evidence="3" type="ORF">BQ5605_C120G13288</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000028">
        <property type="protein sequence ID" value="SGY27774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000038">
        <property type="protein sequence ID" value="SGY28558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1087"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="455"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY27774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY28558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1880" mass="206297" checksum="5C1959D0F2412BAC" modified="2018-09-12" version="1">MPDPPGAQAPPPDNPLGGNRASDDESLNTLTREPVTGGTANPPAWSTEATQARLDCEKVMQNTFRVLGIVPSGKSTRRLMVLMHDASTPPSQAPLLARAAQRAVRNDAAPASNVIRVIMDGPGSPRGPVQIALRKHFGLAETPFMFARPEGVVLDPEVEKLFSKCVKLNPIVTKATKRFPIARHMYELVFESDQACLEAAAAGPFSHHGKEMVTELPSASPLNHVVQVRFTLPSSSSATPASVLRQSLDDALTLSFGRAGRTQGYTLMQLQRGLAVDPNGDPMAMTEDGFHCAYLRLHADLFQGSTETQKAALNAALPQEIEILGAKYGLRHEFETHYCAVCDRAGHQWGACRKPVSTPATAAPVPGASTSTSTTGFRVAGKNGKHGGPAALNSRASGTNMIQLGPRANPAGAATGNKDDANDDDGDDDDDGGGESVASTEPEGGDTGKETLTRATTGPTKETQTTTAAPVSTPTSPSPSTSAPASPLSGGTSESSATSTTSIASTSPRRLRSSSAPGNRRVTRAGSAMIHGASGGDDSGGNSSGGYRSESLTVLTFNVRSIKNAVNQVKIIRYLKTLRPAPAAILLQEHHLSYNASREGFESAWPGACIRFTPHVLTLIPDGSPLAGHLLSSTPVVFAGAPRLDGRILRSVFRLEELDVEIINMYAPVQEDDRRDFFGLLHFNAPRPKTLRILAGDLNDCPDVSVDRVSITDRAWTPVSHWQTLLSKIAFNALDTVRHVHSCTPAFTRPHYRGRGEERKICSWSRIDYILVQCSWANRLLSASTLFDAPCSDHRPVVATFALPTSNADAEPPLSLPSTSDFISRLNPTVFDDQDFVASIPGVVDEVYRRLEGTAPLGDVYDAALRAVAVAGHARYRSTRADMRRLRAESQSVMEALEARGEHMNEAERDAYAFAKSRLDQLAVKEAQWLRIRAHVPSVDSREGQSASIRTRLNRRSRQTSIVSLEDVDGTETVDMQEALGIASRHAQSLFTPDPARGDPTNARRSLLDPIRAAKCYDDDRSDPTFGRRLPRQARVALDEPFTLLEVEAALKKTDSGRSPGPSGIPYELFKALPTYFAPKLLDLFNSIWEGGKMTASLAEGLVRLLPKNKPGANLKSLGAYRPITLRETTYKVLSKVLVARLNGVLGELLPPAQHGFMPSRRSADAGSHLTLLLEKLKSLGTEVFPEGALLSLDQQSAYDRVDHAWIFDVFEAFGFGERFISLLRALYDPETLGVRYLINGFPTELVRLLCGLGQGDPLSCPVWNITFQPFLDALVRRGIALDLQKVWPGGPRAQLTHLAFADDAVVVVESPAALSKLETLSQTWYEATNGKTNTDKTLVLPLGPNWLRDETAQALPTVQEGESFKWCGYAFFRHGDSKLFWTHVLDRIKAKTRAAGDRTLSPSGKVFYANAHIISTVLHVLSFDIPPQWFIKAAETALTDFVWGGAGRNTVARDFVFQAREDGGLGLISIGDIVHSVALRFWDAVAGSNEAIWAPLARESWRSLVAATRDFSPWGFFSSTARVEKLYRDSTRWGAVVAAARVTVPTIKSELLTLPELLSLPPRLPSLYAEGAKHAYDDADAVAKFAQIADLYWRDEGKGWALVGHRRGFWQHSKEPALQHEHVWSRVGQLLKAKALLPKTALRPARIPLKEAPRPRCFNFFGLTRPFTIRKLRRLVNVVRFPGREDRVKRFRDGTPQSDRKRFWRWLHDRFASAVEQDTHWRLMYDVTPTRKRQHTQGHASSPTCLFCGNDAAVIETVSHYFFECAYSTSFWGGVLRILFDKLGIEDTDVDPSTFTPEQLTMGLPLLRGRGRTTSRWMWVRLACAIGFQRLHLLRWRVHQRFELDKVVAPPSLPSALRAFERDFLSRAGFVPGARDWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M146</accession>
    <name>A0A2X0M146_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C003g02225 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C003g02225</name>
        <name evidence="4" type="ORF">BQ5605_C003G02225</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M146"/>
    <dbReference type="STRING" id="796604.A0A2X0M146"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051733">
        <property type="entry name" value="WD_repeat_DCAF13/WDSOF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851:SF1">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 32 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA U3 SNORNA ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="696"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="702"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY39468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="716" mass="82907" checksum="96D2902A886FD734" modified="2018-09-12" version="1">MAFPESTLKRKRPLGIPRITFVRIELNRRRALVLPVLRLFLPGAGPALPQSRLLSSHINTEYKRRDSIPDDIIEMHFARTLLVVVASWIVFVGPLILLVLTVRLAFRSKNVFKTIFRPEEIERIWRWEIACGHYPSAHPIDITFGTHSHQAGVVTQIPNPARPFIGSDNLLVEENTSLTVKIVPTGPSRFYLVPEPLVQIDGKTYLSRPASNAALDMDQVMEHCEFPKGYVRDCLTFLRGESVDIKARRRYFVAEEADSMLSEQVLSEVEVQRASMGKVISVDSNLQFERKLQAREQLSLASLPMISSPLRQRHATFPNADIACDPEHPRLLHMYWTGPFTDKPYMAVISFLYTQNLGLNIPLGEHPSKTHCRPQLWIWINPVSAAALLPPEDAAEQIQRDLEANKWSSALLHPRWRDVVHFKLWNTSQQLDNAEELKGWREKSLFNSHGYKYKQDTVKKTNEEFRRVGTADSSHYDRLSVVMSDMARFLLLHQYGGMYVDADTIFLRDWEPLFSWRGAFAYRWSRLNLYNTAVLKMDRKTALGHFIVRTSVENGFDFHPMSVAHYTQNAKTQNLLKMLPDALFDPAWLNTENYQRDRPAQPYFKKFEDFFQPPKKGRGGPATFDHFFKGAFSYHYHNFWWQPFDPVRNYPDLDPKVERASLSGQEQGEMSWSTMLKRHFEAFIRAEERNMYGEMIDLRPEETDDGDDVIDDDDDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M1H6</accession>
    <name>A0A2X0M1H6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C002g01042 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C002g01042</name>
        <name evidence="6" type="ORF">BQ5605_C002G01042</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY29324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M1H6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF287">
        <property type="entry name" value="MFS MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="431"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="466"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="512"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="341"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY29324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="535" mass="57590" checksum="B429F5B0CC8162E6" modified="2018-09-12" version="1">MKTRSSEIDKVTQEAVDSTELQSWPPSPEIEARADDHDLDRDDEITSKKRSSGLHTPSTPEDVTPSPMELESMDLSQHHFSTSTTTLGLQRQSAAPSSLGQLPEADRSPEAYRFLFVAFIVETVIWGLPSAYGVFLSYYMEEGVHGSTVGAKLLPLVGACASGTMYLLGEDFLWDDYPKGPPVALLLNPYPSFRILAIRIGCCILVLALLLSSFAKTAWQLLLTQGFMYSIGGSLAYYATFTFLSEWFVQRRGFANGVCFAGTALGGVLYPFALEALLSKYGSATTLRVLSVLTAALLGASMPWLRPRIPVGKGSRSKAKNDPASNEATRRRRMSLWRNTNLWVFMFANIAQAFGFFVPTLYLPTFATSIGLSNKIGSATLACVNASSVFARVYLGILSDRISPHVIGAITLAASAFSVFILWGVTSTSLAPLLIFSLVLGVACGGWTSLYAAVIRNAARDDPNLCTTLFGLISFTRGLGSILTAPISSLLLAHPLHHVKASVGFGVEGGKYGGLVIFAGMSLVVAATSELFILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M1N0</accession>
    <name>A0A2X0M1N0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C003g02445 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C003g02445</name>
        <name evidence="8" type="ORF">BQ5605_C003G02445</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY40932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M1N0"/>
    <dbReference type="STRING" id="796604.A0A2X0M1N0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF9">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="84"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="86"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="24"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="134"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="330"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="412"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="478"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="540"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="589"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="672"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY40932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="743" mass="78750" checksum="486CDB333CFDC853" modified="2018-09-12" version="1">MSTSTSNFPSVLLPADQAAFAAVIAPSHSPSSPGSNTADSTTASKQEWPPVYAHRASQPQSQQSHSHSQSQSQAGTMDNPLIPKRRRRTSPDELRILEAEFQANPLPSQAQRAALSARLGMTGRALQVWFQNRRQKEKKDAGTYLGTSGDSSEGSATDQDRDAADLEGLSFAMSSSPPRPSRPSPTEPHRHHTQVRGHARGGSYLHAKALESLPSSEQIYRRPDADKENQAVPTATSSSSDSASISLATTANRGLPSVLNNATGSAFHTWHISAAHTAPIRHTFTIPAAVSSGVTPPLPVYVVEPTTNELPDQFQHRSSTTSVIAAKKHIKRRPLGSHAPTARKPSLPHSFNFPSSPDTATTASSSAAMSKDGRLKAPTLRRTVSNVSINSNTSESFSLQTSECGRASAVWLESQQTQRAESPTSSTFPASSAPTATPTVLRGFKSHDKEVWRLMQSDAPSSPNQSPAPLTRKMMIAHAQAQAQSAENETKSSRHMMLSSEDAPSSDTDAMYDNQPALATAASINARSSRRPNPIRSISLGGTSTSQTSRAGGEEACAVSALERKRQRALETSYSAVPTAPAATKPSRRGSSGSRSTTSRSSSAGAPGRSNSHNGPRRANSSEKTRLTAARKMLRIDTGSSSTHDPKSFVSPREALSSSQESVDENDHEDGSSSMGDLSYSSTCTTSTTSGLGTPKLEAESYFSLGGKGAASMVKMDCSNEMVDQERECAELLLGLGGGGIFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M2D0</accession>
    <name>A0A2X0M2D0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C001g00120</name>
        <name evidence="15" type="synonym">BQ5605_C001g00171</name>
        <name evidence="14" type="ORF">BQ5605_C001G00120</name>
        <name evidence="15" type="ORF">BQ5605_C001G00171</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY44130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY44545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M2D0"/>
    <dbReference type="STRING" id="796604.A0A2X0M2D0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000008">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="12">
        <location>
            <begin position="16"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="13">
        <location>
            <begin position="96"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGY44130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SGY44545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="132" mass="14075" checksum="1F34BFA421E7E305" modified="2018-09-12" version="1">MSSGGKSGGKAKAGADSKTQSRSSKAGLQFPVGRIHRLLRRGNYAQRVGAGAPVYLAAVLEYLAAEILELAGNAARDNKKSRIIPRHLQLAIRNDEELNRLLGAVVISQGGVLPNIHSELLPTKSKKPEKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M2Z6</accession>
    <name>A0A2X0M2Z6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01350 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01350</name>
        <name evidence="2" type="ORF">BQ5605_C002G01350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY32333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M2Z6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13975">
        <property type="entry name" value="gag-asp_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY32333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="406" mass="45061" checksum="705088D88CF886CB" modified="2018-09-12" version="1">MISIISADSEDDSTTEPVMNSPNPDSSAKADETTCPAEQYSDGEQSSDDDSEHSSDEEPDSYFDRLIGADAELALSSLRRIEAATRAATAGKNDDTADVVGLFPDAFMVEVSVNGEDGIKAYIDTGGSHTFMHASTAQRLQLPVHRYPEPLKLDLGTKGSKGTAQGFTITDWRCAGVSCRQLFIIANIDEEVLIGRDFIRKYRVVIETDPDVIRATRPDGTGRLQPNKRAIASRKKQHPTIRAVNTTSSDDTVFPSEEEKSQFLQEIIDKYGRILVTDDEPLRLPPKRAIEHTIPLRPGVVRDNVVHRYPWPDSSLPAFARFYKKHVDAGLWVPCTSTYADPMFSKIKDNGELRPLIDLRERNQLTIAQVMPPQDQDEILNAVAGAKFCTLADIQGAFYCKNVLMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M3C2</accession>
    <name>A0A2X0M3C2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminopeptidase</fullName>
            <ecNumber evidence="5">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C001g00430</name>
        <name evidence="10" type="ORF">BQ5605_C001G00430</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3 5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="5"/>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY46416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M3C2"/>
    <dbReference type="STRING" id="796604.A0A2X0M3C2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF174">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="9">
        <location>
            <begin position="38"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="7">
        <location>
            <begin position="341"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="8">
        <location>
            <begin position="631"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="4">
        <location>
            <position position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY46416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="987" mass="111625" checksum="B68C750E7F9F6251" modified="2018-09-12" version="1">MVEGNRFDDSNRLPSSVSTKPHYGPTASAAVCDPTCRPSHYSIRLLTDLEALLYKGASITTLTVHEPVECITLHAASPLVLHESNAFLFSTGSALAQESHAPKRWSDHVEYDGEKAKLFFHGGKIEPAEYKMALRWHGELNGSMKGYYTSTYPRKGGEEGQTHVFACTQFQPTSARRAFPCFDEPHFKAIWQLSMISRVGTTSLSNMHVDHVEIMQDRRRFPSDELLDDDFYFDAKATDQDSTGNIEFDQAKGALGVSKAPSETDQSIVETDWVVVSKAKGWHIMHFHPTPLLSSYLVAFANGQFEYREDHFTSVGMDGRTRDVILRFYATWDQIDKTLLALETTRRLVPKYEQVFDIPFPLLKLDTLVVNDFDLGAMENLGLQMGRTSAYTFDDSKGSSVAARKGVVSITSHEISHTWFGDMVSMDCVRHTYGRMSHDRPPRTYLERPSLLRIRTPRPRIKLDALRSSHPIEVRVPDEAAISQAFDGISYSKGASVLKQLCQWIGEDKFIEGVTIYLKKHLWGNTKTIYLWEGIAKSSGEDVAKVMDNWVNKIGFPYVEVEESVKGLKLTQHRFLSSGDATAEEDETLWHIPLQLLTVDPRTGERKVNRTLLFSDREMEIALPDIEKKIYKLNAESCGVYRVLYPASRLERLGEEAIRPDSSLSLTDRMGLIQDASVLASSGYSESSSFLALANLIAPTEKEYLVFSEISSALSAISSVWWEEDESVLEGLAKLKKRWFAKVAKRLGLDPIEGERLEDVELRALSWSTMASSEDPATIKEFQRRFRPFVESNDSSLIPSNLFLTIFRTCVQHGGAEEFAKALQVIFERLNPVQFSAAVSALCSTLDEKRLQETLEFVLSKQVKTQDVSSFFEWLSMNPLAKRKLWGLLKSNFDALIKRLDGNFQAPYIFGKAFNTFTTDKDADEVEHFFEGKDTHIFQQALDQNIPMLFLSASTQGLEAIRANAAWLRRDRKDLRTWLQKNDHISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M4F9</accession>
    <name>A0A2X0M4F9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C003g01922 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C003g01922</name>
        <name evidence="3" type="ORF">BQ5605_C003G01922</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY37938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M4F9"/>
    <dbReference type="STRING" id="796604.A0A2X0M4F9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050181">
        <property type="entry name" value="Cold_shock_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11544">
        <property type="entry name" value="COLD SHOCK DOMAIN CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="2">
        <location>
            <begin position="148"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="345"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="436"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY37938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="520" mass="54746" checksum="F0AFE3B50713C46D" modified="2018-09-12" version="1">MAMSTYPALAHHHHHYQSAQQQMHDAQSRTAAASAHSNSSAALDLDLSNLSLQDAPHRQHQHQHQHQQQHPHPALHNLHQQHFTSRSGFEEPSHQAPQSQRSARSHPNDFVHPLRSSQPTLFQPQPFGASNAPPDHPLHATTKLDTPRRRGVVKFFNSLKGFGFIVDNDPAALGGQEVFCHFSAISGKGGFRSLAEGEEVEYELVQGPKGFQATNLTGPQGESCGRTVVGDPKARMTKPPPYMPFAMPQFLSTDPYAPQGSVFAAAGSPYNLVYVPASVAVSPGQFNGYGHALAPGREGRHGASPFGSNYSFTPPGPMNGAPGASSHTNGVDSSRGGTGNDSDHYSSSLSEPTSYPSSRGGIGATPAAPFGVADYGKDNALFDRDSTRDQASNTANGSSFGFAPFSPASSSQLPLFDDGARSARAFDSHLIPSQAPGSSSNRPSSRGSLISASSVSGNVVSSLLPAPSNVFDALRPAPIGSRSRSPGTNHGTPLGNGSLSGNEWKSSAVLYTSASSSNEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M4J9</accession>
    <name>A0A2X0M4J9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g02214 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g02214</name>
        <name evidence="2" type="ORF">BQ5605_C003G02214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M4J9"/>
    <dbReference type="STRING" id="796604.A0A2X0M4J9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="965"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="966"/>
            <end position="976"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY39412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1231" mass="137774" checksum="F30B48EE5B9A5C7C" modified="2018-09-12" version="1">MAGNTTSRPCPCSWCKGASVSKATFYRHHARQPNGPRATEEAAILEVPRQPSMLLAPPGPQSQLFQPPRPTPSWFATRSPQKYTQSAERIVSRKAFVGSSMGAQLNDSALSNDTQAYGSVSSNISHTDAPNSPSLPYESEEFSMNISPELPQIPEGDYDFERASWTGGSMDSFEGHALESDQDVLRQTQLFEMTSALETTSPALQPLDNYSSSSLPFDDDDPLVVEELWGADQRLDANGVYNTPTTSRLSSSQERAVAEEEVRQEIELAKALPYYDVDTLYDFSFRHMYNMTRQASKIWEVLGSRPSLQKFVDLGLKPVRIPCCVKTCVAFTGPREALTRCPVCNSPKLDQNGHPQNTFLYLSPDVYLNIYLRDRVYASLMRYRSDFERNRDPQEVVDLFDGDRYREKLDQNISWTNPPIAGASQPTVSTINVKYYENDVDVAFGLFTDGIQLFNKTQSECWPIMMINYNLPPEIRYKKKHLMTVGIIPGPKGPKDIDSFLHPLYEDARASARNGHMVFDGVTETMVRQRWFIHVIGGDGPALSKMLGFKGPTAKWPCRVCLIQGVPCAAAHNHNYYPLKMPLDSSHANRSDLTALDLPMRSEATIREAASEKNPTFGLSKLSSAAHLPGFSLHQDGPSDFMHAVFENVARKLFNMWHGDLAAQKSKGYKTQAPQAQRGRSAQGKVTSAASAEATTSAAAVDEALGTDLPDWVIPNKIWEVIGQEITNGAKTIPSLFARKMPNIHLQTGAMTAEDWSNWILYVGPCVLHDRLPAKYFAHFLALRRWVKDCMAMTINKEDVAKDGALRRDIASWCTEFESHLTLICLVYLGFILYYSGKSAHLINLPHSVHAVLHIADFIEWHGPPAMTWCFAMERLNQTVKRVASKAHRLPYEAVNRLSVMLCPRNTNVCADAALQMACSRFPRFSYPITVPALMKHQQDKQMELEQMQQSRGLFMNATGDQMRGSSAAASRQASSENGDSGAEALGLYGRRSDKLKQGPGINDVMRVAQFIARELFGQLAPVVFKRKVDAIRTSILSLSINSFEGYRMDSGRDRIAAAERLSKHARVSADTRDASWISYDLLIDSSRRRARDNSQAFPREGEGADRVKHFGQLLAIYEFRYGEQKFLLGKVRSLGLSHLQPVDTVERAPIAKPTPKRQKRKALSVVGGHKHQNLFFTQGKRASGAVEIVDLRCILGSAGRIHRRVGREESREYIFDRMDDEARPNFLNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M628</accession>
    <name>A0A2X0M628_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g02472 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C003g02472</name>
        <name evidence="1" type="ORF">BQ5605_C003G02472</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY41119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M628"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY41119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="335" mass="34695" checksum="7C5CCF41B335075E" modified="2018-09-12" version="1">MMESRDDVEETERVCAFLAIVLGWGNMVMGAVSWVVLIAAEVIGAVASLVELSRRSTELAPGESVNFFSVRLANDVPVVATESNGGGTSPEAEFKIGAVRDSPARAGFVASAGGEGASTNTSGDLVAVVLEGSPTSATACSTMVFSRSRLRARASTEGTCSDEPDRGLDGKFNFEVFTGEVEGEAASAVATEEERLFPNHVLRLSKAVIVGGLEAVASFAADLFSRQDARLNDERLVDDELVPSFSRVPSFSKADISSGLESPSLDRLLQGRIRVVDADSSSPVAEVVASWAPFFPPTVGTVSIKLGSASAFSDCPTTGASAGAGSDKSGSLRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M6L4</accession>
    <name>A0A2X0M6L4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g04316 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g04316</name>
        <name evidence="2" type="ORF">BQ5605_C006G04316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY57865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M6L4"/>
    <dbReference type="STRING" id="796604.A0A2X0M6L4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY57865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="626" mass="70362" checksum="E37A3149CA8C4781" modified="2018-09-12" version="1">MEVRIARIEPPRSPRALQRSQPPLGSSYLEDGKELVVPTDTSLPIALLDESIIPSDGHPPPSFLAGVGPAPRIQRQFHFGVPSFDPPNLSLFTSSSSRKHLTGPLPRATFLPGRLLLIDETQRQHLSQFNFTRTINDKYLEELLAEHPDQPFVHSVVQALRHNRFKPEHDGSFHHNFIQQMVDEEVQKGWISSGTGTPLPGVTASGLNDRINRSLCPATYDTIIDFIRLLCWHRFSNAKGSLLGQDAVLWKLDVSSAFKILVMSERWQAMQGIAIKRRLEDGSTVTWYHIKWRGVFGCWAMPFLWTRFMSLLMWAAHCWYRIEHPLAYMDDTFGIDLVGDLVPFAHDGATYEIPAQQAVMARLWGNLWIPFKLAADKAPFGCRVTITGIDCNLDEFTVSLLHSTVTKLAAAIEPFLKTPDRHPTLRRWQQMAGWLSWALNVVPQARPYITPLYHKIRGKVNSDTGVPINKDMMEALMQVAVLIAWGPALDLASPSLTRWSLANADLVIYTDACLQNANDTGAGLGFWFATAGGTRRHFYCRPQRTYLRIQFAKLLTIIRALDIATDPIHSYGPFRRVLVRTNSAPAVYTLDSGAVHNTDFMPLRTLTLACCCRSVSSYVASIDDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M710</accession>
    <name>A0A2X0M710_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C007g04477 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C007g04477</name>
        <name evidence="8" type="ORF">BQ5605_C007G04477</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY60733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019783">
        <property type="term" value="F:ubiquitin-like protein peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="7">
        <location>
            <begin position="891"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="1185"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="16"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="62"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="975"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1075"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1464"/>
            <end position="1523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1606"/>
            <end position="1638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="979"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1476"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1510"/>
            <end position="1523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1608"/>
            <end position="1617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY60733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1667" mass="187149" checksum="AAC5C3BA43B607A5" modified="2018-09-12" version="1">MAPVALIMSTGEMSQLLQNKGGRPPIALQEQSSPEGYASEVDSEVDEDEDSLQVLAALVPVPSKSSISSPSAVSGLLISPKSRSRDSDEDSADEGYYGVDDDNSDEKSIDNIFSALLLARNDKKILDRHTYEPSRQDKELLNTTREAIFSNMILTTAEHNELRLGPLVLNCRKPRSEWEFVRKLPVLELPKFMATEKHDWAPRKYERCLAVVERPYGDAPSSTHHHHPSEVAVGIEWRPEVPITLREAWSQPGEGRPVAEVLRITHRCSGACKRVRVKDGKLGYKKRDNDKDPGKTCSTQLKILVQADDLSSALVYTLGNHKGRQPPPNVRRPAPFIRALAHQEVFRQANTPTLAFQSECVLQVCTRSFHFSRLTISSFLDDGLDHFTDMNQRMSVWEKQNEIILPQYRKVGAKQLRNMFRAKGRQNAQHGSALYSLARTAELRPFTLQNATEPKTSGVAYFQPFNEKTKQPLICVLASLHSIDVLISFATVGNDSGDWSRFVGLDSSWRYLNENRAPLTALVATGLKDKLALGPMLLSSDVKADTLVIYLDTVKRLVEERAAILVRKARENGPNLPGSSPRLPNLLQNAEFILENQWQPPNFMIDKCRTELNALTLYCSHDFEFLMIVVFCIYVTIGKEKHNLNFHIRLCQFHVVQAIIRWSSDRNDGERGNTLKPSRIARKTLINILYEFRSIIQRFRFIRTEHETDAEATARRSAEIEGKKRAFFEKSDAWIDKEFRSRRKPAANKSDVTKKSELGCNSREEEQLQAKKDNFRAYFNVNWFVQEWIDDGLPLGVSRETIKTNNVTERAFKTIQQEHLHGRANKRIDNLVVVLPDNALVYDIWKDVSNAKPDHVLRDTLANSMDIWELGQFRPTEKEGQWVLSLRSMDSSITLDTRAPYCPCRAFKQTGNKCAHLWACDLLVHNGDYHTAMNRIMAAAAAAKAMSDMRDGTKSSKLHDASVEALVDKVLDSKMPSALEDDNEPDEPLSEDELDERDEVDSDVEDEDERAADIADKTAKPKLSKSKSNSGVTLEHSGRVDGKATAAIRRLIRDKLNPDQLRPKTSKHTIFENGTTQFGKTRGRPRETKFSNSLSSTKDHAAAKRMAAIPEVIDIEELSDDERPPCQLAPLQEGRLPLDIYDTVQPEERRSNVSAVKDIIKRIPNEVQKVDWDVFLDIHAGDHAPGLNLSSLREMANANLWLRASHIDAFSSAINRFQGQLPFNGRSKEVLDLEPTCYAFYLEGGKCAKGIGGTRPTERQQGVSSDGSSRAYLSIIIDRRPASLFALPLYQIILSRTPVLLFPTHVTNHWILVEARLSDCTFRVYDSLFGRENMRKEANESLDSIITFLETRAEGPIERITGGIDRPTVPYRNWKRLIVKAGKAGDQPQPDSYPQQTDGNACGAFVCRAMETLVCAAVAKMEPDWSWGPQVEPGRFYSELRDYLLDVTLHSRLRCDMSSSWFSGSPESPTVSCATRDPDNTMDSRKPHGNTQPGDHVGYSSDDAEEVSQHHISTPVSTRSVTFEGSRLARNVSSSADTVIIQHPQPGGLSHVGSVQGNNMSTARTRLASDQSDSPLNRPTLAFPSFSPVFATRDIEHLPKKCKYSAVPQESSPSAVVTPSKRRHSAAESVTPSSSRRKACSQCRDRKLNCTKKRRGKASQVFTCEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M7G6</accession>
    <name>A0A2X0M7G6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00417 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00417</name>
        <name evidence="2" type="ORF">BQ5605_C001G00417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY46349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M7G6"/>
    <dbReference type="STRING" id="796604.A0A2X0M7G6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY46349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="330" mass="36398" checksum="0739F3050BDA632C" modified="2018-09-12" version="1">MSTKDTKPHKTYHYLAYGVDLHPKLLSARLGPIKPLSSTPVIVPSAFLAFDVEGVPFSSPACTNAIVQGVNDIVWTAKSSKPHTVRSDMTNAEKEKDEDYREWIWRRCCPGLDCTGLLPPRLEGVAFELTEADFRSIVLDFSSPTSSSLSGNLHKDTARSEAAWPAIPIECQPFTPGDSTKTAGTLTVYIPTAPLSITRRPNLQPSNEYVRLVILGAFGSLLSQPYLGHLVLLRPYLPTATICKRIGRFVVNLIMIPPFLCIHMPLYAMGYGMRTSAVARKTDRLVARLVIKAESALSWCTGSGWWNERELQGEAKIVLDERGEVVPQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M7K5</accession>
    <name>A0A2X0M7K5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00769 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00769</name>
        <name evidence="2" type="ORF">BQ5605_C001G00769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY49334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M7K5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY49334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="143" mass="16460" checksum="DACB475FDC2D7B61" modified="2018-09-12" version="1">MISTFLFILRVMSHHLPPQVPHASFHPHYQTIQPNLHPHQPYTVELYRSCRRSGPRFFPLLLVGGVSVWASNKIYKLRQENYDLRDRIRSDDKASLASATIASTSLSLDEGKDTNNKATSGRGEWRRDWRGRRYGGPRGEEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M7N1</accession>
    <name>A0A2X0M7N1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C007g04707 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C007g04707</name>
        <name evidence="8" type="ORF">BQ5605_C007G04707</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY62556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M7N1"/>
    <dbReference type="STRING" id="796604.A0A2X0M7N1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015244">
        <property type="term" value="F:fluconazole transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF23">
        <property type="entry name" value="FLUCONAZOLE RESISTANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="494"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="526"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="556"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="153"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY62556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="595" mass="65559" checksum="5E34D4A20A2AAB9B" modified="2018-09-12" version="1">MTPDIIRDSTVGQLINRFTHGRVLPYAEQRPDYVLPARYRAALDGSAIKYSTSTAAASVTTSRTATAAPSLKEGAEGDKISASGNAQAAHTFLDLEKSDLHRGTAPHEPTAALKDLEKADLHESAPVAKDPFLVEFEENDPGRPLNWSRRKRIFVATLISYLTFSIYIGSAIYTPSIPGLMQSFGVSQVVATLGLSLFVLAYGIGPMILAPLQEMPRQGRTPVYIIGLLLFFIFQFPIVFAPNIATILVFRFFSGFVGSPALATGGASMIDIFEPRHAPIAIAVWSIGAVSGPVLGPVIGSFAAQANGWQWPNWELMWISGFAFLVLSLFLPETFEPTVLIRRAERIRQLTGDNRFRTQAEIDAVEGESFLELLWTNFKRAFQLAAEPAVFFANSYIALLYACFYLWFEAFPILYVETYHFSLGISGLPYLAFIVSGLTTFSFYILYLLYHLNPRMGKPDFQPEARLELGLVAGLFIPVSLLIFGWSGQNQTHWIVPTIGAGLYLPGIFLIFQCILMYVSSSYPPALAASILAGNDLFRSSFASVFPLFGTRFFKVLGLGGGSSLLAGVNLLMVPLLFMLMKFGPRLRARSKWIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M8R7</accession>
    <name>A0A2X0M8R7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C001g00828 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C001g00828</name>
        <name evidence="1" type="ORF">BQ5605_C001G00828</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY49858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M8R7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY49858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="551" mass="62259" checksum="C270C434868D68C8" modified="2018-09-12" version="1">MSSYSSPFQFDSRDTPPTTVVAPNHWHSILYKRVYKGISILSPVADLRLVDLLAYDLPAPDASLRLALSKDDPRHFDALPRPLKQSIGKYSDQSFLSLAYLDGYRSIAFAVSGSSAEKIRYIIHNIQEQVSQLANADAIREHELASARHHLTRIRWTAVDRVYLRGRSTRLQDFLQILSELRLVLRNTSESTVRQGVPPNVNEAGLNQVLDRLRLVGSEPLPCIMRREECDALLSVTALDIDQEVLIDAVDAGFDQADAEEEDRQFRRILAEACYEHEQSTRVPNQWEAPPYPRDLLEKGALYSVPTLDLDSLLARRRAHQCRHLEKIKFKGGAQNSRQWEWTGIDSLWGTRGTFASGTNIREKTLHEQATTAIITEGRFHVYGQIMSNHALVRAVDGNVSALHSLKVDTLVVYGIPEDPMGLPSGEQCGERLAIGIGMPNYYLLRNIYKKSSTTYESVESLDSLALFANAVIQELRVIAPGVYSNLSHQGNTRIRQVDGRCIMYSLKPNLSSINYEVKDSTRPNWRDEGEIHITVNQEKRYRLLQNIKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M9V4</accession>
    <name>A0A2X0M9V4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C006g04003</name>
        <name evidence="4" type="ORF">BQ5605_C006G04003</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY55324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M9V4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY55324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="175" mass="20052" checksum="728E32707EB90018" modified="2018-09-12" version="1">MCDLIVRDEAPMQHRRCFQLVDRMLQDLRSSTARFGGLTVVLTVIACANRRRLHHGMLASGGKLRGCISWQILNGSVRWSDRRVGRSLASWNADFWGEVEMDNSKNTDSCTTSRRSEDQQQHCQWERPERERSGPVRSHTVLRRTLPLPHQHRRIILLPEDLGHINCGDSGKGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MAJ2</accession>
    <name>A0A2X0MAJ2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g04244 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g04244</name>
        <name evidence="1" type="ORF">BQ5605_C006G04244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY57247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MAJ2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY57247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="215" mass="22744" checksum="4BE1739759D9F83B" modified="2018-09-12" version="1">MVEQGGNNPGGTGDAAGLPNTALPLAIVKSCGPHKFPKTRREAAHQEGGSISECLRTAWNAPVADKKQSALRQRSVLDGETIQSPKFVYDVKALRDNARIIVQRGALLRKADFRSPSSKLKLLGRPGSDHPIAACRRAELQAGGRAMLTGGLGTRAPTSTASEVTMAELSAPAGLVDAHAGRRSWLLKGQNSLDNTGHHDPSFIVLLHMHPALGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MB81</accession>
    <name>A0A2X0MB81_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C005g03552 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C005g03552</name>
        <name evidence="3" type="ORF">BQ5605_C005G03552</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MB81"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY77081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="276" mass="30809" checksum="D712F3FF50908103" modified="2018-09-12" version="1">MYAVELLQKYELVSQLRVPGWDQIPALWPAPIAEADRVSRPALIPEPGVPLPPARPQLPRFRRGPWGLKTKEEPIDHRREEAVEAVNSYEDDDPAERDPPLPPDDGHEYRPYRVGRTPGLLENINEGNTLPVRTRAQRRVAALSIVSTRKVLRREPELIASVSTRHPPLPKTFKDARASTEAESWYAASVKELNSMGLLKEDAEGNIISYKAQLVVQGFAPRLGIDYNKTLALVLLITTILFVVRLCAARGLVLTSRRRCLSSIGSLSSALACFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MCE4</accession>
    <name>A0A2X0MCE4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C008g05103 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C008g05103</name>
        <name evidence="4" type="ORF">BQ5605_C008G05103</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MCE4"/>
    <dbReference type="STRING" id="796604.A0A2X0MCE4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000099">
        <property type="entry name" value="Ribosomal protein S12, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_uS12_bac"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY79313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="167" mass="18131" checksum="3C5DAE54B5C857F7" modified="2018-09-12" version="1">MAGCLSHSHSLLRPVPTRRPCPTSSYLYRSLSTSRSFSTSPTPQATLNQVTRGARKAIRRPTSTPALQGAYQRKGVCSKVYTVKPKKPNSAVRKVAKVKLSNGRAIIAYIPGEGHNLQEHSVVLVKGGRTQDLPGTKYKIIRGAMDLTGVAGRMNSRSKYGTKKPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MCV3</accession>
    <name>A0A2X0MCV3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C004g02648 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C004g02648</name>
        <name evidence="3" type="ORF">BQ5605_C004G02648</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY66248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MCV3"/>
    <dbReference type="STRING" id="796604.A0A2X0MCV3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="133"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="220"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY66248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="281" mass="30319" checksum="710E39723B627C43" modified="2018-09-12" version="1">MHYKRQPRPALQEDPHMSYRPAPAAAELIATSSVPQRCTANNLECVFEEIMPSVSTINARVEQLEREFQVVQAELQRLRQLESEVGAIKLLIPRAFGIPGAGDQKSLAMSGMIPSPPALPGYFAGGNTNGSVAGSTTSHAASNPSPVGLSQSLGASVRSFGGETGIRSSLPLRRPADDPVASTNVSDDEGDRDDGEDEDHLPRSVFVAPVETLNRLAEEQAQAQRRAADGSWIKPPNRKKPRRAYEPATPPDRIPDIIDKGVLDEIMARDLHAVSVFSLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MD26</accession>
    <name>A0A2X0MD26_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C004g02837</name>
        <name evidence="7" type="ORF">BQ5605_C004G02837</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY68004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MD26"/>
    <dbReference type="STRING" id="796604.A0A2X0MD26"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1760.10">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007204">
        <property type="entry name" value="ARPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036753">
        <property type="entry name" value="ARPC3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12391">
        <property type="entry name" value="ARP2/3 COMPLEX 21 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04062">
        <property type="entry name" value="P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016315">
        <property type="entry name" value="ARP2/3_P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69060">
        <property type="entry name" value="Arp2/3 complex 21 kDa subunit ARPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY68004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="183" mass="20674" checksum="47B10AC04227378C" modified="2018-09-12" version="1">MPAYHSSYNDEDEHRVVGNMALLPFKSRIRGPAPPPADPSRDDIIAEALDLFRANSLFRNFEIKGPADRLLIYLILFIGDCLTRITHSKPAWGQNEALKHLSNYSIETFTIPGEPGFPLNSLYAAPSNRLDADALRAYLTQARQEATMRLVERVYSDGTGRPSKWWLAFAKRHFLGKSLETRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MDB6</accession>
    <name>A0A2X0MDB6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C004g02798</name>
        <name evidence="8" type="synonym">MED17</name>
        <name evidence="10" type="ORF">BQ5605_C004G02798</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 17 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY67688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MDB6"/>
    <dbReference type="STRING" id="796604.A0A2X0MDB6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019313">
        <property type="entry name" value="Mediator_Med17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114:SF7">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10156">
        <property type="entry name" value="Med17"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="68"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="546"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="71"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="546"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY67688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="638" mass="68871" checksum="F89BA5FDC87E9538" modified="2018-09-12" version="1">MSTTHISLEPPAITAQDGLDDDLFVPAARLYEVTHDGQQVLTRQDSNKLPTERLLRIWQERGDFSQLTSRRIRDEQNKDLTKTSSTDEHSGEQDEHKDDVHELGITPEQMSELRMTMMQQLELARGELTTALDLLSIIAAPTVATTVDAEALPLPQQTLTIVPSAPPIPLPSSENDDSTNEHTGASTSLLPLATSLASLRESANSFFSASSQVLASTSNSTTSTSTSPSRNPTSKQWSTLLHLHTSTPFPLIPLGARSNASFSGQGETRLAKQVGVFYGCAEAAPSFRRAGVAQVEQVLQEVEEGREGMGKGVGRKRGRKLVVEVEMEGRGRDWCVWTSGAAEKEGKEQGVEDVLKQRGRNVFAEELFAVLSNEARSDVSVKSRLELGKRSQGDSVITEGHGWKLKITMVAVPEPKLEAPIPEPNAIAPLLVPLLRLLLIQEYIRRRSPTSFSTSIPILPTVSAFLSYLYRLNSLCGVLTTLTSTIDPSIPTSTTYHPSLASAPLSAVRKILSPPTNSNELKELGGRIVLRIGSSPTSLFHISHSTLLPQPSSTSTTNPSTSPSPSMGVSAFALTSHQGLVLQAPRSAPVVVGSVGQLEGFLQEQIGEVLKGCAGREEVEEVNGKEKEGMEVDQSSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MF94</accession>
    <name>A0A2X0MF94_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GPI inositol-deacylase</fullName>
            <ecNumber evidence="10">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C008g05012</name>
        <name evidence="14" type="ORF">BQ5605_C008G05012</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the GPI inositol-deacylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="10"/>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MF94"/>
    <dbReference type="STRING" id="796604.A0A2X0MF94"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050185">
        <property type="term" value="F:phosphatidylinositol deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006505">
        <property type="term" value="P:GPI anchor metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012908">
        <property type="entry name" value="PGAP1-ab_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039529">
        <property type="entry name" value="PGAP1/BST1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056824">
        <property type="entry name" value="PGAP1_TMD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495:SF7">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495">
        <property type="entry name" value="NEGATIVE REGULATOR OF VESICLE FORMATION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07819">
        <property type="entry name" value="PGAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25141">
        <property type="entry name" value="PGAP1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25140">
        <property type="entry name" value="PGAP1_TMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="829"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="870"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1049"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1116"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase PGAP1-like alpha/beta" evidence="12">
        <location>
            <begin position="208"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase transmembrane" evidence="13">
        <location>
            <begin position="831"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1188"/>
            <end position="1212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF25140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGY79010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1212" mass="131732" checksum="FD9441973753509A" modified="2018-09-12" version="1">MPDPAGVASQEPGLLSSTRSTIAPDALDAATTATTARPKSAGYVVHAATNRSSFGRTPLAGFVAIVLVSLVALVTVLLAHVVSPPRYPPGSLPPDAKGGGAGACRQSWMSPSYLHISGTSLPLFRLWSSRVPEAHARFFVARSPSPSPLTSPAPNPDSTAFGREYSRLGAGPWGLYLYREEGWDDDPFEPHVGHGAASTDPTPRAFALTGIPVIFVPGNAGSFRQVRSLASAASRAYYELPGVRRKGMGSKEGGRPLDFFTLDFNDDFSAFHGQTLLDQAEYLADSIRYILSLYHQESNAKQGRPDPTSVIVIGHSMGGIVARAALLHPHYQSGSISTLVTIATPHAVPPVTVDRGVDRVYDNINSYWRHAHHLEAMSSPPSRRDLRGEAELSNLVLVSISGGISDTTIASESASLTSIMPLNDSHGFTVFTTAIPGVQTPIDHLAMLWCRQLMETVATALLVIVDVRSPLGVLPREARVGKLAERLLGAIESHPVKPEGRKSTLESLERGQHGRELAIGERLSLRGHGDKRSTFVLPIPPRRTYGSARVFSLLTSANIGRSLDSLVEVYACGKNESAPESTHSSSCTSLFPSFVTTIPISPHSAQSPILPAPAEDGTMAFLDVDVSQLESQDVIVVVVKPGNAWLLAEFGDKDRRVHTVDKSAFQLMLGGFKIENFPTTPSLISELWLPALDSSLLTFKMKVFRSDCQGERREYSMPAHFYHLSATNPIRILADSSTVLFAPLLRQYSSLLHESKYFPNVREASLYTHASGPYLPAPASPFVSSGARLQLIVDPTCARENSRASADVAIEIKLDLWASLGNLAMRYRMAVVAFPFALILLVFACQLRDYNSGHSFPPFATALGTFTRHHLMPLLGSLVALSFLQSVMLGTRLSFVEAKLASADAHVLPSLPPRWISEMLLGNQGPFFAFLGAFILFTMLSVVVLEYAALYLLVTVLARLVRLIRQRGPSQMRSFVTLVEPRETLPLQRFVTMGALVLFVLFFAPYQFAFLVLFLVHLLSTVRALLLAQDASAPSTPASTRRLWDRYHYSFVSLLVMIGLLPINAMILAVWVRNLAVGWLAPFSTDHNVLNILGFLLNVEALHSGKMLQRTPGPTASTVSIALPLIAAGFALLYGIRWTYNIYPLANAFFLWLASNHSHHLVGALNEAVKAKRRLSISTAGQHVQSNSVKQLSSSALSPSPAPRTPTKRQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-05-29" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MFN2</accession>
    <name>A0A2X0MFN2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C014g07597 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C014g07597</name>
        <name evidence="5" type="ORF">BQ5605_C014G07597</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY19243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MFN2"/>
    <dbReference type="STRING" id="796604.A0A2X0MFN2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01277">
        <property type="entry name" value="HINT_subgroup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039384">
        <property type="entry name" value="HINT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648:SF1">
        <property type="entry name" value="ADENOSINE 5'-MONOPHOSPHORAMIDASE HNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="HIT FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="14"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2 3">
        <location>
            <begin position="102"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="1">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY19243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="144" mass="15985" checksum="0C0E1FE35BFB36AA" modified="2018-09-12" version="1">MSSSTDYKTDPNCIFCKIVKGDIPSFKLIDTDRAYAFFDIGPLAKGHALVIPKYHGAKLHDIPDEDLTTLLPLVKKIAIAVGSEDYNVLQNNGRNAHQQVDHVHFHMIPKPSASDEQGLVVGWPTKPADMAELKAYCEEIKNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHB0</accession>
    <name>A0A2X0MHB0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C032g11035 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C032g11035</name>
        <name evidence="2" type="ORF">BQ5605_C032G11035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000067">
        <property type="protein sequence ID" value="SGZ03970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHB0"/>
    <dbReference type="STRING" id="796604.A0A2X0MHB0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ03970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="225" mass="24254" checksum="BD504CC15C3C0D79" modified="2018-09-12" version="1">MPDPPGNPPAPPDDPLAGTGTSDASLNMRLSDSVAGGTVNPPAWSAQASQARLDHEKSMQKAFKALDIVPSSKSTRRLMVLLAVQNDAMPASNVIRVMMDGTGSPRGPVQTALRKHFGLAETPFMFARPEGAELDPEVEKLFSKCVKLNPIVTKATKRFPIARHMYELVFESDQACLKAAAAGPFSHLSQISSPRSERSATAQLTQRWELSRSFQSCLPSAILIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHH4</accession>
    <name>A0A2X0MHH4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C011g06267</name>
        <name evidence="3" type="ORF">BQ5605_C011G06267</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY11771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHH4"/>
    <dbReference type="STRING" id="796604.A0A2X0MHH4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="128"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY11771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="364" mass="40513" checksum="95E7E60767E9B257" modified="2018-09-12" version="1">MSTLELFLHRQLVTLHAGRIDFVRLRIRVIGTPNGNRSNAFPLFPSHRLHKSSISLMLREGQAKRSWKKRSLLGFGQREHTLLPLYHRVLLHSYCQKAARHICGSRSRSTSSTTFTCNVPKQGQLAELWDEAPMQHRRCFQRVGRMLQNVRSSTARFGGLTVVKSEAMPSRYSTARFDGVTVVLAGVPKQCLPIIPKSSPTPIVDACIMNADFCGDLSVNQQCVFWLLAAADRMTETEQAKAQRFADFFGVGDGLASKTEDFIALPRELLLPATTRNRSRLIRHVYPRAKVAPKNSQVDHINDMGLDLLPGDAQTFYSADSVENEDESHCSRSSIFRVSTSPGWRCSTLDAGLDDGLSPSGGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MI76</accession>
    <name>A0A2X0MI76_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C030g10829 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C030g10829</name>
        <name evidence="2" type="ORF">BQ5605_C030G10829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000069">
        <property type="protein sequence ID" value="SGZ08972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MI76"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ08972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="122" mass="13361" checksum="9EEDAFB8974E1562" modified="2018-09-12" version="1">MSDPPGAYAPPPDDLLGANRASDESLNTQTRETVTGGTANPPAWSTEATQARLDCEKVMQNTFRVLGIVPSGKSTRRLMVLMHDASTRPLLESVGVLKERIRRMHLLKVPAFFGVLVNRVPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIU3</accession>
    <name>A0A2X0MIU3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C018g08792 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C018g08792</name>
        <name evidence="1" type="ORF">BQ5605_C018G08792</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY26791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIU3"/>
    <dbReference type="STRING" id="796604.A0A2X0MIU3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY26791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="100" mass="11317" checksum="2817EBBD1B8B84B6" modified="2018-09-12" version="1">MRGLIQVGESEVLEALRRADLYCSPKKTELFRTSCNFLGHVILRNGIAADQLKVERIMEWPRPRTVTELWGFLGLVQYLRKFINGLACDVVTPAQAVVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIU8</accession>
    <name>A0A2X0MIU8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C028g10545 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C028g10545</name>
        <name evidence="7" type="ORF">BQ5605_C028G10545</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000080">
        <property type="protein sequence ID" value="SGZ13063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIU8"/>
    <dbReference type="STRING" id="796604.A0A2X0MIU8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000004">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018038">
        <property type="entry name" value="Ribosomal_uL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005998">
        <property type="entry name" value="Ribosomal_uL30_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_uL30_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012988">
        <property type="entry name" value="Ribosomal_uL30_N_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01310">
        <property type="entry name" value="uL30_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08079">
        <property type="entry name" value="Ribosomal_L30_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00634">
        <property type="entry name" value="RIBOSOMAL_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30 N-terminal eukaryotes" evidence="6">
        <location>
            <begin position="14"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="5">
        <location>
            <begin position="59"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGZ13063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="215" mass="24272" checksum="B18566FE04CFC65F" modified="2018-09-12" version="1">MTNDSSSAYGTTSSKRQVAFKRAEQYVNEYKKAEREEIRLKRAAKAAGNFYVPAEAKVYFVMRIKGINNLAPKTKKIMRLLRLLQINNGVFVRVTKATSQMLLMVEPYITYGELSLSAARSVIYKRGALKINGQRIPITSNQVVEQALGKYGILTIEDIVHEIVTCGPAFKQVSNALWPFKLSNALGGYRTRKFKTFIEGGETGKREHFINDLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKB0</accession>
    <name>A0A2X0MKB0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mannosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C021g09313</name>
        <name evidence="12" type="ORF">BQ5605_C021G09313</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 22 family. PIGZ subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="FQNC01000083">
        <property type="protein sequence ID" value="SGZ20936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MKB0"/>
    <dbReference type="STRING" id="796604.A0A2X0MKB0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF3">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="197"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="418"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGZ20936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="572" mass="63313" checksum="6BDC2843C1E003C7" modified="2018-09-12" version="1">MVGSRGTRYNEVKSPTAGVWKRIRTLKLAQLLKDRRWQLLVVLRLLVALSSQSVIHPDEHFQNPELAAAWVFDYSNTGQGPLKTWEWLDQDPVRSVFPVAASTGVAFQLLRLVLGPRQSELVCLPEAFFLFLLSIIIDICLQSIARSNTPALVFATSPIVFAFLVRPFSNSLEAILLALAIFVAHGILTQPPSKLHYATYALVTSLGVFTRISFLFFTLPPVLAILCRELLSRSSTLVRTATRGAPAVLALGLLSTVLVSIDTYYYRGTLLSKHWVLAPLNLLRYNVATTNLETHGLHPRYLHIVLNWPMLFGAGLWAATAAVLVCKAAPVSGPKVVTKGKKKGKAKVEAIPAKNLTGLDGVLLPAACFVVPTLLLSLQPHQEPRFLVPLIVPLSLLISKASFLTIGTSAARRNRRIFWSLWCLHTILFTLIFGYLHQGGLLPTLIRLNESLRSNAFDSAQNVDIIFWRTFMPPRHLLVPLRTTPLQVTIKDVAGAPLSELLTIIHNSNSSRTLLVTPAYAYDALLSGKVDFARPLYGSRSIGIHLDMDRLQDMVGVDWRRLGMGVWEVGHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKC4</accession>
    <name>A0A2X0MKC4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="23">BQ5605_C002g01325 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">BQ5605_C002g01325</name>
        <name evidence="23" type="ORF">BQ5605_C002G01325</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY32166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MKC4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0229">DNA integration</keyword>
    <keyword evidence="18" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="16" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="15" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="16" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="17" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="22">
        <location>
            <begin position="535"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="249"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="784"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="21">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="301"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="800"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="SGY32166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="826" mass="92506" checksum="39FEA56D8E88333F" modified="2018-09-12" version="1">MFSETTNMFAVSDKSSSEVLRRTNYDTWAQEMILLLRSHDLWEITKIRMDPSIIEIPEIVDPDLDLYVDSVPLADHILDDSLSPEESRELHLDARAFYLIIRSLDPANKSLISNCSTANQRWDALRTYHLGERNSQIALISAQLSRMLFTGKSSISLEDHMIKIRDLNLKAKQVGYPRSNTEIAFQMLNSVTDPKWANTIEALSLTSDPTPTKIIARIKEREVTFALTNRIQGGTSLLLPNDPATVQTVAANSASDPKGSRKTGKKSRNRRKPTDTCTRCNGKGHWACDKECPGKRPESVASVNEGHNSKSGPPSRFVVGAHVAREMPTASSSRCSTALATARDPTSKLEWVGDSGAIRHLIGDRSLLRNFTRDPIAVQVADGSIQEVEGYGELSVTTKQGNIIDFKNVYCLPGANLALISFFSLCDNGFELRMTDGGKTISVYLDNKFVCATERDTAYYFDFTIYNEPVAVVTRASAGAPLMWWHRVFGHLSPRTILNMVSTKMIVNIKISDETIHDCETCIVANSRAAPFQHVSREPTEVLYRVFINLGFVDVPDHKGRFVYLVIVDQLSSMKWTYPLTSKSAAEVLQVFCRFQAQAERVTGKTIKFVRSDNGGEFLNRSFEAEFTRLGITHEFTARYTPKQNGKAERANGSLFAMHLRFKKKTIFEIFYGKKPSVGHLRPFGAIAFVLLPRQLRRKLDDHAKKGIFVGYSGEYNYMVLVDYTTSPKVLISRDVTFTDSLSEVPSAPADVDRDPEHFAVEEIFEYDLIPQLRDIRLDPAHLPVQDGPLAPAPRRAPDDPAQPQAPVRRAPYYGPQGLEIEIART</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLR7</accession>
    <name>A0A2X0MLR7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C030g10807 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C030g10807</name>
        <name evidence="2" type="ORF">BQ5605_C030G10807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000069">
        <property type="protein sequence ID" value="SGZ08639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MLR7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF15">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE (DUF1295)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ08639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="344" mass="38568" checksum="60618D5FF39CB4A7" modified="2018-09-12" version="1">MSPVTVLDQYYLAITFLISLGLQGALFAICFIFQTDKVTDLGGSINFFILALFTLLAGNTYYARNIVASVYVMVWSFRLGAFLFYRVMKTGKDGRFDEMRSAVTKLGGFFLFQLFWCWTVSLPLTILNSPAVSDPARGGGNVKFGTASLLFVLAQDIIGIILWVVGYTLEVMADQQKFTFKFNNSQKGAINDKGVWGWSRHPNYAGEIILWWGMYALCIAPATHGVASSGGRNALIASVVGPIFISLLLYFVSGLPQSEKPTQKKYYLMSHGVDPESGDKWAEYKAYLNRTSILFPLPPALYRPLPKWVKQTILLDAPMYRFDEHKEGKEAVEEQRKKMAQSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLW5</accession>
    <name>A0A2X0MLW5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C024g09898 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C024g09898</name>
        <name evidence="2" type="ORF">BQ5605_C024G09898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ26368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MLW5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ26368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="265" mass="29191" checksum="69D3DB01A2A2C9C3" modified="2018-09-12" version="1">MMNMVVTLQKMNNNSLPWLPKSKLAEPIYAQLNNARWLSARRMLGSRLTNEETGQSRRFTFAIRDNVPRAYLSLAYPSGSSSTLLQSSSRASTTRHPAPATPLPDPAFSRSTSSDARTTRSSPVHANDCNGGGGLLTPAARSARGRLSGAQLGLKKSATHAPSPSPAEAMQLMPTSKEESRKGKGVQRFETQVLICRDDDDKASEDDSPSSGLSESNAERRQVQDILAGKQRIQEMILSSDPKRDQRRKRYLRHRTLVRSDSQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MMV5</accession>
    <name>A0A2X0MMV5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C026g10207 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C026g10207</name>
        <name evidence="25" type="ORF">BQ5605_C026G10207</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ27856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MMV5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="380"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="125"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGZ27856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1046" mass="116464" checksum="B034A37B5C81ECFA" modified="2018-09-12" version="1">MELSNAKYDEDENMGEFLKSMIDKADQLDDLGQKFGDEAMIAYILQALPPSYEMLKQAIRLGENRSVDHVINRLTDEYTERKLLGKFDKLLKNAGALAVQSTRASRDPNCVCRGCKGKGHFAMDPECPKYDAKKNHGRARNRNKKKKQDSKDSADSNELANSALTVKSLDESHSLQDNVANRVSQVNQGEIWILDTGASQHYVEDASLLSNRQSGNLKVQTASGQVVHCDTYGMVYFKLKSGASLSLANVYHLPGVPVNLISTRALFKSGAKCGWEDGNLKDVMTITYQGVILAKTLSGTGYALDFTRIVEDQAHVATRATVGAPLMEWHRRYGHVPVSSIMELVKSGAVEGLVLTDEKVHDCEPCISSKSRASKFSELATQVTDVLQRVFMDIGFVAEDQVDFQGRKAYLAIVDQYSTAKWTFPLKTKLAEEVTRVWITFQQGVEKMTGRKIKRVRTDNGTKFTNKLIGTDFQSQGILHETSAPYTPQQNGTVERFNGSLMAIVCAVLAASKLSWKYWSYALAYATFVANRILHAKLEGKTAYEVFYGKNPKVLHFCPFGSTVYAQVPKSKRSKLESTSVKGIFIGYDSEYNYRVLVDPDSDHKVIVGVPEVTTLPVGPDEEKGPVDNDDVVVDKLQDQVDDPAVKGRNPGRYEEIDANNEIPHRTRSQRRDAEQQVMYGSAMSVSLSPVPSNYKEAMASPEADKWIAAIKAELDAMARHQVLIDSDLPSGARALGSKWVFTRQENAQGEVTRYKARLVAQGFAQRPGIDYNETFAPVARPSTILSLVGTAAAQGLFLEQFDFDSAFLNGTMMEMVYMKYPKGWDRPQTGQALQWNAAVNSLMVERGYKRSAADSCLYVKRVDEKFIYITLYVDDGMVASNDQEFLDAEIEAFNKVYKLKRLGPVKLFLGLEFERTSDYIFVHQSKYIRDLVAMYGGGSVSKHPVKVPMEPRSDVKHSTDPFDDVALYQSAVGALQYAAHRARPDIVTSVRAAASKVSAPTQADWIAVKRIIRYLQGTVDWGLKFNHGGSTVFELYSDALWETTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNV2</accession>
    <name>A0A2X0MNV2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C056g12666 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C056g12666</name>
        <name evidence="1" type="ORF">BQ5605_C056G12666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000095">
        <property type="protein sequence ID" value="SGZ29459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MNV2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ29459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="155" mass="17617" checksum="E31F98932D34172C" modified="2018-09-12" version="1">MWVRLACAIGFQRLHLLRWRVHQRFELDKVVAPPSLPSALRAFERDFLSRAGFGAGARDWERFLFLDGSASQVDCLCVGGFVNRCWIPLNGSFVRVGQDLRHGSGRKVARFWSISSRQGGLVSLYWIAFLSAPTAQQPALEIQPREDIRRCRGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNX7</accession>
    <name>A0A2X0MNX7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C023g09682 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C023g09682</name>
        <name evidence="7" type="ORF">BQ5605_C023G09682</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ24015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MNX7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="CFEM" evidence="6">
        <location>
            <begin position="11"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="69"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="154"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="156"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGZ24015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="270" mass="28610" checksum="0AF7FB7BE8841014" modified="2018-09-12" version="1">MRHGLREARRAQHCKEFTNVKCRCQDREYGKLYRQCVRERCTVQQLPFVNEVENTTCASYKLSETKKGGIGVHLTHPNATAADEGNSEPKDQRSSPSKKKSTQSTSESPTSTRTKALLNATHDIPSSATAVSPSNVDIVYANLTKEVAEGTGIALPNTTYTTPDTTSPSSSEMTNATSTTAPTTDPTFTNATSTTGPTTDPTSTNTTSTTPLSSSSSEQSTNASLAEGNSLAGTAIGRFSKSAGARCLSTPTLEGSLAFALVAMTVYFQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MP61</accession>
    <name>A0A2X0MP61_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C023g09762 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C023g09762</name>
        <name evidence="1" type="ORF">BQ5605_C023G09762</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ25077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MP61"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ25077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="202" mass="23109" checksum="573458CAF28ED6D0" modified="2018-09-12" version="1">MDRPYTIRRVRRVLNAKAFTDTIGFRDSLQPDDLKGFWKGVNSKALTAREREVWFKLVRNFTPTRSLQFHQKHDDSPACLVCGAPKDDREHYFFDCVDSGNVWIAARSVLCDALGLDTIDNTNYTAVQRMFGLPKLKASLRDQEGAGRTIEIFTGLVLEMISSGRWGMQKWGTRMEGVGRRRIILEERLKLRAGGAWGRRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MP69</accession>
    <name>A0A2X0MP69_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C053g12603 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C053g12603</name>
        <name evidence="2" type="ORF">BQ5605_C053G12603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000098">
        <property type="protein sequence ID" value="SGZ29879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MP69"/>
    <dbReference type="STRING" id="796604.A0A2X0MP69"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="31"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ29879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="219" mass="24893" checksum="3041E53DF9CF7162" modified="2018-09-12" version="1">MAGEDREDWSISLMTEYSILNGMNTWDKEATDPPPGVRAIPTKVVLVRKRNDKGDIIKYKARIVARGDLQNHHGETFSPTARIASIRMINVIAHVKGYRRLQFDVNSAYLHGHITEPLWIKLPDGSTHRLRKSLYGLKQSGREWNKVLHAALVDRGFKRMEEDFGVYRRVRNIGGVDRTTLLAIYVDDGLLARDDDLEGFLSVVVGASLVTWRLIDDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPD6</accession>
    <name>A0A2X0MPD6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C101g13142 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">BQ5605_C118g13271 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C118g13271</name>
        <name evidence="5" type="synonym">BQ5605_C101g13142</name>
        <name evidence="5" type="ORF">BQ5605_C101G13142</name>
        <name evidence="6" type="ORF">BQ5605_C118G13271</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000074">
        <property type="protein sequence ID" value="SGZ10902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000108">
        <property type="protein sequence ID" value="SGZ30335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MPD6"/>
    <dbReference type="STRING" id="796604.A0A2X0MPD6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24178">
        <property type="entry name" value="MOLTING PROTEIN MLT-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="230"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="324"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="377"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="470"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="531"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="556"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGZ10902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGZ30335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="586" mass="63269" checksum="C0DE3BCFD0835714" modified="2018-09-12" version="1">MAHAHGPLSGLGTLGPPSRRVLRWFPRHSCASATQIPNTPLVPDWFWSLSIVAHGVRFAATLASLSASQRLRQALVDPKSTITHLERLANKVEDVRNINPSTRQTSLALAARAGRLDVCDWLLFDEGHEEIEISRDAAGETILHIAAANGFVDLLNMYLSQYPFVLDWVDARGATPLHIAAMKGQLEAIQVRTGPARATLPSIHESSFGNWRYSQILIHAGSEIDVRDMFGNTALHYAASWGSLPVIKLLIELDCDYNAINGEGFIPYEYAYSFDVARAMKEFYEDRIVERSRKAKRRRARRARIAAPSPSLSGESVAHSDNYAYESSSSMERDPSPIGICLGSPSRSGPGDTLRPAPRQNQSGSSSRRTSQREGPNGSSKRNSATSDLATAFNQLSELPDSNASRSETPSRLNLFGRKEGGSGDGRGLPRSPISPPPVTSLSPTDLSLDGRRSDEGISSASVAPRHRPQSSVFPSQSTLVAKQDGPPIPTRSRTLDPLVPGHTLFTVRSDERDPSSSNRMRLGKLTKNPSSGTATSTAMGTELDQTSLVPGVLRSRTTGSVVSSASHGGRASRMAKALGLGLGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPH1</accession>
    <name>A0A2X0MPH1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Prolyl endopeptidase</fullName>
            <ecNumber evidence="3">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C001g00032</name>
        <name evidence="5" type="ORF">BQ5605_C001G00032</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase S9A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="3"/>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY43543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MPH1"/>
    <dbReference type="STRING" id="796604.A0A2X0MPH1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050585">
        <property type="entry name" value="Xaa-Pro_dipeptidyl-ppase/CocE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056:SF5">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="4">
        <location>
            <begin position="460"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU368024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY43543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="673" mass="72666" checksum="7A9F07075AB10170" modified="2018-09-12" version="1">MSSATTTGSRDKFGSFESPITLDLVLGSFIGLSMPLYNQASSSLYWLENRPSQKGRNALAQLLLPSATSAASDAKFTKIEVLPDEKWNARSRVHEYGGGSYATLGNGGLVFEHVEGGSWVVEPKAEGGEWQQPKRVTKESKVDRYADFSSAHPRASSLILAVHEDHTIDEPAKVVNNIVLMDTSIEATPKVVVAGADFYSNGKYVSWIEWYMPDMPWEGSLLCVAPVRLSDDKKSIEVNVAAKQVIAGQVKNVEAVSQARWAENEDRLVFLCDRTGYNELYQWTEGKEAKMVLAEPTAHDVGPPDWVFGTATHAFLDSKKWISVAKGGDLRVIDIESGSSEVISVPYQAIHSITVISPTQVVVEASVATTPAVLALIDLASEGSEPRVLETESSASVDPGYISIGQEITFPAEDGTDSYAVFFPPTNKDHPNGSSDPKEKPPLLIYAHGGPTSSTGRGLEWGIQLLTSRGFAYCGVDYAGSAGYGKAYRQRLAGQWGIADVSDVVSCAKFLASKGYVDPQRVGITGGSAGGFTVLAALCAAPDVFTCGISHYGVSDLALLAGDTHKFESQYLFGLVGGTNEEIPEVYHDRSPLYNADKIRAPLLLLQGTEDKVVPPEQAEKMKEVVLANKGKCELVLFEGEGHGFRRAENKKAAIEGQLEWMRNTWGIVGGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPS4</accession>
    <name>A0A2X0MPS4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amino-acid acetyltransferase, mitochondrial</fullName>
            <ecNumber evidence="5">2.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Arginine-requiring protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Glutamate N-acetyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">N-acetylglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">BQ5605_C024g09782</name>
        <name evidence="18" type="ORF">BQ5605_C024G09782</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">N-acetylglutamate synthase involved in arginine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the acetyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.1" evidence="5"/>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ25851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MPS4"/>
    <dbReference type="STRING" id="796604.A0A2X0MPS4"/>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006592">
        <property type="term" value="P:ornithine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000070">
        <property type="entry name" value="Acetylglutamate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006855">
        <property type="entry name" value="Vertebrate-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342:SF4">
        <property type="entry name" value="AMINO-ACID ACETYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04768">
        <property type="entry name" value="NAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51731">
        <property type="entry name" value="GNAT_NAGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="17">
        <location>
            <begin position="531"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="SGZ25851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="745" mass="81631" checksum="1C1D80CBF78AF170" modified="2018-09-12" version="1">MARSVVQWSSFARGPACTCSSTSLVLGAYCTRPRIAFGADRVLHSRQQHAARGHSNDKNSQRVSGGYGAYTSWVVKGRAPVVPGWLPRLSRAAQRSSLGRNTVDSFALEGNLSTCHHDSQDLILSVLEAHPSARDSRFYLQNFGASAAPTPSSSRSQNGSHSAEAPAFPLANGATPTTAFAVPVKTSTGTNTDLDDIIAGKTPFADELLAPENRHTALVKIQGPFTERQLESIAEGMVYLKKLGLVSIIVVDHEEWMSELSRENERASRFSIEERRARTIRLRAQMKADTMRLCEMLERKGGSARPLLEGVLCVRGAEFEDSFKPIASTSKLPTESDSSRPPSDLFVDSLSGIRDSIRRGEIPVIPPIALDQSLFSLCVSANDAVRAISAGLADHAKRAGLRYEADRRWNKDVDLTPVRLMIINQEGGVPSHARRGNPHLSINLSSEFDYINETFVWQDSHPTSLANLALLQDCLAELPRTASAMLVSHRSPRSLIANLITNKPAHSPSLHESLLPSTQMRHQPTIVRRGLPIRVFRKMSDIDLPALTKLLEASFGKTLDAEPFYAHLEKTLDFCIIAGDYQGVAIVTNEAPLEDSNGDEAVSALGASESRPVAYLDKFAVLPSLQGDGTVDFLWGALRDESFGLGLLDALNPNVGGKQGLGEGRDLVWRSRSNNPVNKWYFERSNGFFKIPPPRGSQVGFALFWCERESRRGESRDDEEEASKATATKLKEWSRVVGGIPTCWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPX0</accession>
    <name>A0A2X0MPX0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit delta, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">F-ATPase delta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BQ5605_C025g09965</name>
        <name evidence="16" type="ORF">BQ5605_C025G09965</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000087">
        <property type="protein sequence ID" value="SGZ26816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MPX0"/>
    <dbReference type="STRING" id="796604.A0A2X0MPX0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.15.10:FF:000003">
        <property type="entry name" value="ATP synthase subunit delta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="entry name" value="F0F1 ATP synthase delta/epsilon subunit, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048938">
        <property type="entry name" value="ATPD_C_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01216">
        <property type="entry name" value="ATP_synt_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="ATP SYNTHASE DELTA/EPSILON CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822:SF7">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT DELTA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21334">
        <property type="entry name" value="ATPD_C_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="Epsilon subunit of F1F0-ATP synthase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP synthase F1 complex delta/epsilon subunit N-terminal" evidence="14">
        <location>
            <begin position="27"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="F1F0-ATP synthase subunit delta C-terminal" evidence="15">
        <location>
            <begin position="115"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SGZ26816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="159" mass="16959" checksum="E8FB32F26CCE420D" modified="2018-09-12" version="1">MFAVARRSLFVAPRLARGYAEAASEKLRLSLVLPHETIYNRQDVVQVNLSAVSGDMGILANHVPIIEALAPGVLEVIEGSSNETKKWFVSGGFANVHPNNLLTVNAVEAYPLDAFSPEAIRSALSEAQRVASGSGDAAEKAEAQVEVEVYEALQTALKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPX6</accession>
    <name>A0A2X0MPX6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C024g09832 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C024g09832</name>
        <name evidence="9" type="ORF">BQ5605_C024G09832</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YSP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ26093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MPX6"/>
    <dbReference type="STRING" id="796604.A0A2X0MPX6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140268">
        <property type="term" value="C:endoplasmic reticulum-plasma membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120015">
        <property type="term" value="F:sterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13220">
        <property type="entry name" value="PH-GRAM_GRAMDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051482">
        <property type="entry name" value="Cholesterol_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319:SF4">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="786"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="8">
        <location>
            <begin position="547"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="269"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="443"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="510"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="740"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="98"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="228"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="443"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGZ26093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="885" mass="95966" checksum="0950F8EAAAF2BE06" modified="2018-09-12" version="1">MSDGARDSTPCSSPASHSDDSEECHSDGSLVLVNKREDPPPLGAAAPLPATTTQPRSRRLAPLVPSPIVTAQPGASAGLNPTSLQPGASAEPHLALDTSSLSPFSPSPTSTTEMVATTSFSSHTSVVHSGEAGVDMPARQALQDNSREVVGGPASGLYPEVVTKVTSSPVDTPTSGSSSSKPWYAKLATPLVGKHHGKSRRNNRELGEADAGSESSDDEGDVGGDAGENDKKEQDVKAAEVLDEVNGRKEVSQFLRGRVPNTCVENLSRPPLLPLQPSTPIHQAGSARQGLAPVAVPDRQLNPDRNDSPSMSESIKDRISEDHHPSPKVSNFKFHKLFASEIPDDDELIEDYRCALQKDVLAQGRLYLSEHYLAFKANILGWQTSVCIPFFEIVTIEKRMTALVIPNAIEVTTLNTRHVFASFLARDPAYDLLVDLWRHNHPGEERSRESKDQDSASIVSDAGGATGVNRGGDVNSEISYEDEHGERKKHKFTNALAKVGSRLKSITAVNDDKPEGKTEAEEIKDKAKKDMQGELGHEPTEYDGEEFANVALDCVLPISPQKAYELFIHDSEFLKDFFTDDQGLKEVEIGEWESNGDGDLQKREMSYIKPLNGSIGEYFQSNLPFKKRHTYPILLPPPSGPKQTHCNIKDENEKVDPEKYISNITTTQTPDVPVGKDFSVRTKTVTTWSDEGGARVRVTTEVEWTKTNRMLKGIIERSCIDGQKKYHQDLEKAARAHIEANPDDFKDSGVTMTGASGGSKKGGDDSARASASEEGESLLSSFLEQLTGPMGIVVGLVVILALTNLFTLNALRVQARVAHHARMGQPHEVASAVSRVLDQYKSVYSTTGSKSSAEVEMKSLLKVVEDLEKTATGLVDRVKSVASML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MSN6</accession>
    <name>A0A2X0MSN6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CCT-beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C006g03938</name>
        <name evidence="8" type="ORF">BQ5605_C006G03938</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY54956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MSN6"/>
    <dbReference type="STRING" id="796604.A0A2X0MSN6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000025">
        <property type="entry name" value="Chaperonin containing TCP1 subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000002">
        <property type="entry name" value="T-complex protein 1 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012716">
        <property type="entry name" value="Chap_CCT_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02341">
        <property type="entry name" value="chap_CCT_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY54956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="470" mass="51058" checksum="43EB0A8B2A894B98" modified="2018-09-12" version="1">MLRPSRFYLWNRHDKCYRPGRRIAEGGREAGHPAEGAPADVSVQIVIGCERTVLIMRYPSSHSVIEGFRIASKSALEALEKSAVDHGKDPVAFREDLIAIAKTTLSSKVLAADKDYFAELAVSAVLRLKGSTDLEHIQIIKKQGGKLTDSYLDEGFILDKKIGVNCPHKIENAKILIANTPMDTDKIKIFGARVKVDSTGKLAELERAEREKMKVKVAKIKASGVTCFVNRQLIYNYPESLFAEAGIMSIEHADFEGVERLALVTGGEIASTFDNPSGVKLGKCGTIEEIMIGEDKLIKFSGVAAGEACTVVLRGATSQMVEEADRSLHDALSVLSQTVKETRTTLGGGCAEMIMAIAVDEKAKTTEGKKALAVESYARALRQMPTILADNAGYDSSDLVAKLRAAHYEGRSDAGLDMDRGIVGSMKECGVTESYKLKRQVVLSASEAAEMILRVDDILRAAPRRREGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MT23</accession>
    <name>A0A2X0MT23_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C045g12225 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C045g12225</name>
        <name evidence="2" type="ORF">BQ5605_C045G12225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000115">
        <property type="protein sequence ID" value="SGZ31660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MT23"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ31660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="495" mass="55844" checksum="7F44AF9DAEC1CB20" modified="2018-09-12" version="1">MDILPHTLPPLQPSSASPVGTEKGKRTDKTKRKKSTTVRRRRRRKKVTSNKDTIENGATTSVGTEEEAKTKKKKRRRLWTKRVRKREPSLSPDSELFDKTFGFNFGIFRSPTKRRPKRQPSPPLSPSVQRSTRRRKEHSEKSIAGLHKSSSEPWTDIADGATAWPLDTETGGFEHNFKPNSAPDFEPDYDFGHDFGGGYSSGPEHSPFHPDGASQDQAPSSLKRLQIERNAKKQRNRRRNARAEAKTRASKRAELLQAYLLMKKKAKECNACHERRVTRKVRVVDLFFAGMRELRYCPCYSEIQTLAAHGLLPTSSSSIQKREGITAFTFCTIEYLDTYWGVDPFGIYGMSEALILFWSSESSSEDPFNKKILEASQGPTVRQHIRAAMDEYRFMQQLQATLTAGLLGLSPRKRLADVCPACFGPRIDEAGKSENDLDVIIVEVNVTVHQIATKRAKRGNKATTTSSWVKIKPLRAASAAQIKTRRAPNADSNER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MT99</accession>
    <name>A0A2X0MT99_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C046g12282 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C046g12282</name>
        <name evidence="2" type="ORF">BQ5605_C046G12282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000112">
        <property type="protein sequence ID" value="SGZ30962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MT99"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ30962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="667" mass="69376" checksum="CC156EAE3BCD0CD2" modified="2018-09-12" version="1">MSSMMLGGTSHITDDDLTPLELYSPRHDVDAGCPGSRPPTVSSHDRIDGGRAAAAAGASATSANAHTPPTSPPCYSEKPLPPRKHVSFCPLALLIECAADCKITKAASTILCGAGGNSSSNSAGGTAAAAAPAGATASVATSTNSDYASAITPTSPVMSSANRNKPRIGVKTYCLDLPKASKATAKAWQVVCANFSTGLQPLLSPGAESSGSRNTVTYSSNRARQSSPERDQDRRMFARSRSDSASSLGSSRGSFSSTGKYDHDDEHEDESRGRTGDVSHLPGFIPNAPSRITIKLPSLQRRGTLPSSGSLCPVRSCLKARSASKSSSKPCQTEPGVESPTIPYPSRLSTSSTTSAFPASSRTTRSTPCISPVDSAPMAHRTLMASHLSPDRHALTIPLIDCCERCSRATEVGLCADEDYEEPWSKAARRKRKFDAKRKAGPVNTGKDATKHDGTSKEVLVDAVSCLDAGLGFKRATFAGPTDTTMDSDKIGDEEEEEVGVPTQGLMAAAVVDELGKKVVVDEPEEDGEPYMASGEEEGSGLDSPATSIEPRSAEPSTASADEFGAPEEHHVTQATTASVKNLITSPLVSELAHETPLSEPKLFSAADILPPQVSVVAPNGNKASVSSSSTRPAPTKRKLSLLNFGKGIVDAGFVANLGGGSSRSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MUG3</accession>
    <name>A0A2X0MUG3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C041g11987 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C041g11987</name>
        <name evidence="2" type="ORF">BQ5605_C041G11987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000119">
        <property type="protein sequence ID" value="SGZ33720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="846"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1062"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="867"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="890"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="957"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1075"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1085"/>
            <end position="1095"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ33720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1412" mass="156196" checksum="88DDB1F4445E1D04" modified="2018-09-12" version="1">MVNSEVSLKPLLATNVPMIFTLLVSINFTETGHCFVYLRDILEEVAELTGLALQEDSCFDYWVVDDAATSSTHSTPCLASCRYDQLAAFTAATESSDKVLGLTGFVLDIDSLSAEATITLRVYEHIKARLPFVNITTRPQGRVDAPVPSGAPSASKHDLLVREKREASPSDRISGNLRPNTEPYSTDDKLVNSEDHANLPTSSEGRTTMTDLMLEAYPQEIVLDPWRPNGTWGDVLIVRMDPGSSGGLSHMCFNMWAFSASSSRTDSKGRWKGPRLDANVEYSKYSKRRCMGVFVCCDQSCPGKCRPHTSLSTASRSKLFQEETPQLVTGRPKKAATRKHLAPNVERPSDELPPCPITSCNGPIRHILCSATIARGQREECPGEIYIWHSGYHLHPPPLVSRPSPQHLEELQQLRKAAPQASAAELRMGQMTAFPQDPRHRPSASEICPVFDSTRSISRYAPRVGHSKRNGALPDTLMSAIEARQGQPLAEQIHNPDPRKQPRNDGLRSKSKITSNSLTDSETSFGIQTPQMKARLSETIDDRLVEGNLGWPTDAHNTYFRDNWVLLATVCYSPSARRWFPILYSVGNHERSGFYRRHFAHLFQILDDANYSVEDIVNGVTFVVDYSSAQISDVGRLNVTPNQVSQWTAEAIQIGEKAASGCAFHFIEQVRRFGVRHLSTQTERERFAMLVNTMRNAKSHASIESIAKRTIDEFPVSENWIKWWTRPAIRNVVFKELNGSAERCVATTTNAVESSHWLLIHSCGGERFGPVERVMRLIDFAKMTDRIESHATDGYVRSSTYHEQGNVRAHIKEIKSRNRVPSSYVSDANMPEPLISFAAPARLAGIGFSESPQGPSDLSKGPATPPLSESTKLPPSTSNRSRQQPKNRSRQGNGPTAQSMASKKGSTRVDYPHKRKIPDPPSDEHSSSESSDDVGLTPSIHCNSSEAIPPTDRSIKLHQTSNSKSKGSPPRSDFSGPSRRVPVVPMAVRALNEETELSQILLAQHNARNLEAPSGRKYRIPRKRLAFLLSEPESQSEAKRTCTSVFDIPLSMVASKSELAPSKSARKVEIATPKPASTSTSLECTSDKLPEDSRSAPRVKFAPPKTSTSTSLGSTIVQLHADFWLRSGEDGPVVIIQGPWSDNSCWIDSTLIALLSVANGLEPWLQCLDILNTHTAYVIPPLGDEMVLRLHPRYLALELWDAIRKYTALARKFDMKPAANAIEAYTQLRKRMISTVVGMSKERGSHFTAPFKRGSYSSPVTWLETLHLFTVDHPVLPSAVTLNDPDRTLVELHLQRAGYCTACNCIQIEVSPRRQFVVDWPLLISSLHLPSHSLETLSDVLASVKRPRASSLPSARALGSSLSSPTIFTTIFGSRTYVPRASGLSVGQPLKLYTEAKNSGRRHHKRNCPGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MYY0</accession>
    <name>A0A2X0MYY0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C001g00844 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C001g00844</name>
        <name evidence="1" type="ORF">BQ5605_C001G00844</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY50002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MYY0"/>
    <dbReference type="STRING" id="796604.A0A2X0MYY0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY50002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="345" mass="38440" checksum="F8194C9E73D12BB2" modified="2018-09-12" version="1">MPPISNPIIGDNGARAAKLVTDFILARLAQHRSSWTAKNFGPTKPTPPLFVGVQGPQGSGKSHLVSQLPTQLAPLRTAFLSLDELYLPHAKLQSLAATDPTNKLIQGRGQPGTHDLTLGVSILSSLARINEPSNESQVVELPTYDKSLHDGQGDRAKETISVQGPIDIVLFEGWCVGFQPLDPSTLAQLYTNTSQNPKTYAAPHLDYETPFFIEHSLNHLLLVNERLAKYAKDLWSFLDCFVQIETKRMSYVWQWRLEQEHNMKSKNGGVGMTDEQVRQFIGRQVLTFSLSYMPSYELFQSGIRSKDTRWFGKVLKLVAGREKEVVATEDQTQSDSATSTEPRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N3Q3</accession>
    <name>A0A2X0N3Q3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C031g10947 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C031g10947</name>
        <name evidence="2" type="ORF">BQ5605_C031G10947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000068">
        <property type="protein sequence ID" value="SGZ06473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N3Q3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ06473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="437" mass="47518" checksum="B5B39001CD528364" modified="2018-09-12" version="1">MYPPVIPRITTSPASNKDTDSTSGLSDVQFGSEDPAPKFKLLEGKEAQEGSSITDTASSHEEDRTPGDTSTSNGGDVQETPRITPRTTKSPEDSPTDQFTPTVRSARPTAGSTTTRVTTTRTLHHRGYSLDLPSVKDAPGGSSAISEGFVSPSGSMRSRRTWAAGETYEARMLERNLSALSFQSAATASPLDFHDLVQIYEIVASRRAAFDNLLWSVPSTSFAGKLIEQQALDQTKEVPEADSSFRSLVLNSSASSSFLFQIALGGDSSRSARIISMCLSILISFLTLQLFTRQLQAEAADHAWLEDWEMRHNVTPSDRAHGETWRGYREILPVRAGIYAPLAKFRGFSLWSHGMVVIGMVAVGGKFIKGLNWFQFEGKEHVSDKRSTCSTGLLNIGDAIFFNFFYFFHSLSTVLVTSAINGKAFENCSGGVGSGNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N6S3</accession>
    <name>A0A2X0N6S3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C022g09443 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C022g09443</name>
        <name evidence="9" type="ORF">BQ5605_C022G09443</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N6S3"/>
    <dbReference type="STRING" id="796604.A0A2X0N6S3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33567">
        <property type="entry name" value="CHROMATE ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33567:SF3">
        <property type="entry name" value="CHROMATE ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="382"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="229"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="229"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="251"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGZ22173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="530" mass="56870" checksum="EED2C877F18EE91C" modified="2018-09-12" version="1">MPVTATRRRSLTARLVETVRFYGPLGFTSFGGPSANLILLRKIFVIREKWIDDTTFQDLLALGNALPGPAFSQIAFSISAIRGGTPAAVLSFVLLTGPGMFAMIGIAFGVKRIPNTLPDIAFALFTGLNSAAIGLTTSLVCWSVFLMGAIAACYESQWLYPVLMAASGISTYLFDKATEYRVTRRTRRERIAESPVVPEQSEDIEMDIARPIPAVTRDSIEAETLHKRSVVTRRDSHCESRGRYPTPPPEASSSRPSQGNTSDDAGAEVQEEEPPYFTITVKQGLMICAGFFALLISLIVSRALTPRARIPDFVTNLMLAGTLIFGGGPVVIPLLRSYTVDPGWVAPRDFLLGFALLQALPGPQFNFAAFLGVLVIPSQPFLGGLLGAMAIFTPGILLKLGALPLYQKFKTNGPVRSVLRGFNAGAIGLVRLEVTASAVGPGASSLLIELSSFPPQIYSAVYRLFRVGFVQGSTLDPGVPAAFRSLDQDGFWVSIVAATFVACGWFNVPTPVAILVGAVGGLAWYVVQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N8Q8</accession>
    <name>A0A2X0N8Q8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C025g10088 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">BQ5605_C025g10102 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C025g10088</name>
        <name evidence="2" type="synonym">BQ5605_C025g10102</name>
        <name evidence="1" type="ORF">BQ5605_C025G10088</name>
        <name evidence="2" type="ORF">BQ5605_C025G10102</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000087">
        <property type="protein sequence ID" value="SGZ27228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000087">
        <property type="protein sequence ID" value="SGZ27274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N8Q8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ27228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ27274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="317" mass="34905" checksum="E95ECBC44122B4E5" modified="2018-09-12" version="1">MEIYLGVDIKSQHLIVKALEVLPSLLIEEQYTPSRILGCSASLHTLLDFGQRGLEKGLVVLDPKERKSVENAVRSLAALGLNNDAAPPMTRPMLKQRNTSCSTSFNWFRVATLNGTSILSQAQIIRLPSLLRHESRQLALDLNSLIQHRRAHQCFHLRAVLLKGRHGATTSTSQVSDPTSKAKLSKHGEMHSSVIRGLVHSMGAARLEAVSGVARSIRWTGQATFSRFSTVNETENIGYIEHRRKEIRMQLRARQYTAFAKNPPFGSIDGNVTSATPLKIGSVVCFVLKRGMIPVSCDASNIGEEQLSIGLGSYISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NAB7</accession>
    <name>A0A2X0NAB7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C051g12529 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C051g12529</name>
        <name evidence="3" type="ORF">BQ5605_C051G12529</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000096">
        <property type="protein sequence ID" value="SGZ29538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NAB7"/>
    <dbReference type="STRING" id="796604.A0A2X0NAB7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF65">
        <property type="entry name" value="EXORIBONUCLEASE CYT-4, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="2">
        <location>
            <begin position="586"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ29538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1103" mass="121075" checksum="58F4D00B7133B38E" modified="2018-09-12" version="1">MLASSSRQGWRCSIKPSSKTVATAHDHARTRTLSSSSSRLIAPASSHWSIAASPGSRELEQSDAAPPSTSNHDRVSPGPITTSHQRVLDRTLRAAIHAQTELQNGGPSRLRGQAYTQHGWKRTPQRNNEARAATDLRRRSIPLSSSSLTASHRRSFTSSAPPSAAGAWPYAARPTLADDSNIHAPNLLRNVSLSGSDPELRQSGKATLRTGTSADYDSRADVVLSPGCWVESMDGGVPTDGVFLGKSNEKHDQLLILSSLGVAEYQAIKQGSITCIVPQFISSPLAQRCLLLNPSDPSVLPIIQSLRQFSVRIEDQTRALISLGALRLYELCLSHAQTPHSIDCRTALDLLGYSGEHKPEVQLAIHRLMMQDAEHFIADPALMRTTGTFQLRPHEEVEVLVTVRSWVRQRSPQIMDFVDRAAQVRQHSLLQGTASPSIGTVKPLLKNPLPDVSWNKDDLRIIDFLRFSAETPRALQRNPYLSTTPSIIKLVDAASDRCGRSGVTRRASQQDLPRDKTIDRLHVYTFLAELGALPPWENWVVQESRSLLQPWDTASASLQNETQSLQRSSQGARTSLPIIDALDDVRHDFGSLNVYTIDDASARELDDGISIEPIAASRAGLKTWWIHVHIADPTALLSPEHSISRVARTRVQTEYFPERTWSMLPSFLVDDGRLSLGAHNGGLQRTMSFSTLVDETGRVVDGKVTAGVVRNVKRYTYGAVNAILGHAAADSNPTRLEYPLSGDATPHSQPSVHLRETDDGELAINTPDQVKTDLDVLHKLARALLRRRADNDALFWQFPSSSVTVSPPPDATWQTSSRPTFYSQCPLVTLHLPAAPKSLAWSATPLGSAQMLVSEAMVAANRTAAKFCVERGLPVPFRVQDPPRVSSTSSLSDILALRKPETGEANASDIVRLGIDFLPGKTQAEPGVHWPMGIRDSSGYVRVTSPLRRYSDLFSHWQLKSALSPGAVLPLFSRDQVHVHAREFDASQKQRARLSKNAENFWAMYILRHKFQAAQASQRQGSSLNDQDPYTAFHSRGLTALALRGPSRSEMEGSWRQPVLLRELGVRGTLISYTAADAIAAGDSRPVTIQCVDHRVLVEPRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NBY6</accession>
    <name>A0A2X0NBY6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C029g10667 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C029g10667</name>
        <name evidence="1" type="ORF">BQ5605_C029G10667</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ15393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NBY6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ15393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="142" mass="15913" checksum="9CC92E71F0912761" modified="2018-09-12" version="1">MAATAAHEQTIQEQQRDLVERLLFCKELNIVPGPNAGRMLHIHHHHPLYPPTSAMAMKDASRKLKGSETDYRDVVQPDTIRITLSLATHKSLPRVDVEKALIAHYNTAKPKSMCLFSIPKANISKLGSKFDYLLSDINATSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NMR1</accession>
    <name>A0A2X0NMR1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C010g06081 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C010g06081</name>
        <name evidence="2" type="ORF">BQ5605_C010G06081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NMR1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY14152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="662" mass="67579" checksum="3D46318CA2743BDD" modified="2018-09-12" version="1">MAAVASNSASTSSLGQQHGTPRQQKKLFRSISRFLSGGRSRPKLASESGSRTTVPAAVAPNQRTTAAPPPHATAAGTSSPASATGPRTSGTDSAQSSPRVNNGTATRSAPYVDHVPMEYIGRGAAAGPPPALGVRTSQITASSGGYDEEDELYPHSRRSMISSDAPTRHYDDDDCETDNYSVGADTDASIRPISPASYAPSSIASSSFAPTHATHRSSTSTKPTTHLSIDSGGANRIAVVPGTGMLFSGTPAHAGFLSATAPSSSPLASVPPVNAPQPGDTLQDEQSTISAATSSGPSTPTREIAEPSLTHLAPKGSLAPHDASILGATHAANVPGHTLAHPRNNPHPNGPPPDNASMITLASSSFAPSVFARGPASPSMHAVSGIQRIWKEGGGVPSTSGITADEDASVRALAPSRRASDESLGSRSTWSAAVGRVGLGGPALSIKGRTPSIRTTGTGAEDLESAGPEPDIETEAQKVVRREGARNDAVVAKFDSLSAANAGDAGSLRSAPFMLGSGGLSRYLSASDSVKRGSPSISSSLRGIAPAPSEKGFGDDEDDVSSYVGTERDDEDAATAGEGEEANERELPSHAAAESDIMISATPEEAHTDHVDNEASETNGQRRQSLLLSMELGTPRLGEAELVTPRVGKGGAFWRGDVVVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NRA0</accession>
    <name>A0A2X0NRA0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoribosylaminoimidazole carboxylase</fullName>
            <ecNumber evidence="2">4.1.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C014g07446</name>
        <name evidence="10" type="ORF">BQ5605_C014G07446</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.21" evidence="2"/>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY18699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NRA0"/>
    <dbReference type="STRING" id="796604.A0A2X0NRA0"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11609:SF5">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11609">
        <property type="entry name" value="PURINE BIOSYNTHESIS PROTEIN 6/7, PUR6/7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52255">
        <property type="entry name" value="N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="9">
        <location>
            <begin position="124"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY18699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="662" mass="70305" checksum="92CCAC5C865995C2" modified="2018-09-12" version="1">MLLQAASPLSIPIIVLDPEEGAPAKQVSAPERLPLSQLASTSSQAGSGPGPLSHLNGPFTSESHIRQLAQNVDILTIEIEHVDVAALERVQHDFASTGGRSGEGVRIYPAPAVIRTIQDKYTQKLYLQERGIAVAPFLPITGTGAAAADSVDPRADLRDSVRDAAKDFGYPLMLKSRHLAYDGKGNFVLRSENDIELALEALIPDSSLTIQGARAPTDRLYAEKWAAFVQEVAVMVVRGADGSTRSYPAVETVHRDSICHIVYAPLRPLCDGDYGVGSKQKGAFSISAKPVDERAQELAVRAIDALGEGAVGVFGVEMFWLSDGPFLLVDFGDSCAIACQADLTSMSTGRLLLNEIAPRPHNSGHYTIEACSISQYTAHLYAILSLPLPPIQFLPRSSAMLNLLGLSASAQSDFMGPSGVVRKAIELGAAVHLYGKAGCRKGRKMGHVTIVGESDEIVRSQLEQLVELLPGEYAEKAQRQEATRSARSPLVSIVMGSDSDLPIMLNASSVLRQFEIPFELSIVSAHRTPGRMVEFARTAASRGIRVIIAGAGGAAHLPGMIASETILPVIGVPVKGSSLDGVDSLYSIVQMPRGIPVAAMAINNSMNAGLLAVRILAAGGMGRLNTALAEYAAGLEDEVLAKVQTLENIGWDAYATIKLAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NS64</accession>
    <name>A0A2X0NS64_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C011g06538 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C011g06538</name>
        <name evidence="4" type="ORF">BQ5605_C011G06538</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NS64"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="15"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY12543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="654" mass="75568" checksum="987C061686016A37" modified="2018-09-12" version="1">MSLEHEGSRSQMSQFRCNIAGCQRSFHHVRNLEAHLHVHERPRPLDRVLPTLSAAERSHLQVLRQQRSRQEFFRRRRRRQKNLRNGWPDCDVDGFNSSGSDYDDDSSSDSSSDSEYDHTLDDQPEWDARQKRKFRVEQPPLAGWACRADGQLCDKHTLPPAVPHAHLFDPNNVFYPFQDENNYRYALLARSMSESLFNAMADHAFSNRLQLRSTIEKIPYAHHTEWREEKIIVTAEDLGWSNSDAELPFLQLEHTFRCRDAHHVLQHLLSIPVFCGHQHLRPMKVFEVKSNGQEQRVYGAPHTADKAWEMQDTLDDPTDVAVRIDISSDSTVLSIGTGTASAHPVYMSLGVNTGFLKRENHGGLVVIAFLPKVERADKGNDEMFRIYKRKVLHRALEILWAPIRHLLSVRHLFQFADGHYRYIRVYFGPVSVDYPEACWLISLVQGYVPCCVQEPLKLQEGPAAPRTSADAYETVWDCLGVNGHELMVADPLHQLIKGTMKDIAIDDLFIETCAQIAADAHPRRNKQKLDELIGRIELNMRLMPLHSQLRRFKDGFQHSNWTGKHTRDLMKVGRRAERAPPHIENQQFCYIIADGYGSTLLSNTVQDRNGTLKLKPFPFTTSLLTLRPSVDRSVHRRWIHWTKLTLRQWTQCNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NST5</accession>
    <name>A0A2X0NST5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Dolichol-phosphate mannosyltransferase subunit 1</fullName>
            <ecNumber evidence="16">2.4.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">BQ5605_C010g05885</name>
        <name evidence="20" type="ORF">BQ5605_C010G05885</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="15 16">Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a di-trans,poly-cis-dolichyl phosphate + GDP-alpha-D-mannose = a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + GDP</text>
            <dbReference type="Rhea" id="RHEA:21184"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 16">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.83" evidence="16"/>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NST5"/>
    <dbReference type="STRING" id="796604.A0A2X0NST5"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000119">
        <property type="entry name" value="Dolichol-phosphate mannosyltransferase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398:SF1">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 16" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="19">
        <location>
            <begin position="61"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="333"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="336"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00053724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU365083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="SGY13530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="371" mass="40587" checksum="B081B68D7ACD0688" modified="2018-09-12" version="1">MMRLRLRFGRRSVHVALPLFAVVLIWSYWTLAPSSSRLYDPRTSAIHKPLPQPLGGPITSSIIVPAYKERANLRPLTERIFQAVRDKASVELVIVDDNSGDGTETEIADLRNEGYNVELLVRTGEKGLSSAVLRGFEIARGSSLIVMDADLQHPPETIQPLLDSLSDETPIALATRYGKGVSMSKGWPLYRRVISWGARTLARPLTSASDPMTGFFAIRRDHFLKSRPINSSGFKIALELMLKTPPSRIAESPYSFGLRQTGTSKLSSKVMVRYVGQLLTLYAWKIGILFHVLVALGVGLGVLGLEKAVGIVRRRKGTGPMLVGHMSRERKPMFIPGGGGGGGGGGLRGNSRQLGSTRNLPPADRHGKRMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NTK0</accession>
    <name>A0A2X0NTK0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C010g06155 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C010g06155</name>
        <name evidence="2" type="ORF">BQ5605_C010G06155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NTK0"/>
    <dbReference type="STRING" id="796604.A0A2X0NTK0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="940"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="996"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="940"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="957"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1007"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1054"/>
            <end position="1066"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY14356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1066" mass="119310" checksum="2BE29584967173B1" modified="2018-09-12" version="1">MARGLAQLANEIDLLLGSPCATMGRHKRNRFKFRPDYFEGHPDYKPRGLRSDPQLRTNIPGTRDMVTYTARQIQQRTFNEHARGEASSPSPRPPMAPPIQADFDEAANPSGMDWDDERHSEYGGGYERDFSPAPYFPDRTSHIPIAPDYSATAERLSLADLHQDESFEPATRGQSKQETYKQFVFNDSRLRRLERPALLRQYIAFCAGVKGHLRPLIDVDEELCQGSVASEVPPPCSCESPLTLLLDVSSSDSPCLTYAERLAQIGLIGSTAAAPRSAFTFRLVQFLDSWWSTAPFPVDGAARGLDIFYEQTGWGRPGLSQHKFDKELRKQLQRALDEFRALTTSERELGDLVLGVAGSLSDKCPACYGSTRLNQAHHRVEVQHLVALDGNFQHSRDTSAKYDFQESTPALFIGEGELESMKEICDACADSWKAANGGATQISRGKSDTGLVACVCRHDIALKMANLYQSGEKRYYGLSLLQHISNQLPSNDTLGVLYDVACNLDGYMQSRSILPDLFPRLKFATSVFHAFAHQWPCQLEYNPRLIQHFGLTDGEGCERVWSQLRSLIPINRPASASHRRVNISRRIDLMNKNGVDSLGILCHPHFHAVFDLQRAAQAATTAGQRRENEDKERLELFNIVQRLHHVEERLFDPMASDEAKARLQQQLRAYQQEYDRTKELAASDFQHLCNCVVKLRALHKATVQLQCCQERIDSMGRGRSGATIGQVEASKLVSVSQRHSKKVKVAIDMYNKAVGDYRNAATEQSAQILDNLPLATTIKSLVTLSPTDAFWQDGFFVHDTAPWAIDTDVQKGIKAVLLKARAEEEILRIGAEVRQLLAWLEDEDTRFVRVSQAWAEDRVPEETIEAAKKLLGTDGAGEVGTAVWHVLQRRQISFKERLDRLAERDDLSVVWLRTRSPAVHESRPSAFGLIGGLFAGRAKQVSRRSRGSPRHFGRRLSTLNNTQMQSPIAESSRSLSGPSAVDVRHTPIDLDAFRRELGLTPDPAAEQAERDRDDVYERRMEELLGSLSEQEVEEEDDAELGEGGGESGSTRGEDSDDLEILDELMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NVE3</accession>
    <name>A0A2X0NVE3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C012g06910</name>
        <name evidence="7" type="ORF">BQ5605_C012G06910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NVE3"/>
    <dbReference type="STRING" id="796604.A0A2X0NVE3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140824">
        <property type="term" value="F:thioredoxin-dependent peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029759">
        <property type="entry name" value="GPX_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029760">
        <property type="entry name" value="GPX_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF78">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00460">
        <property type="entry name" value="GLUTATHIONE_PEROXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00763">
        <property type="entry name" value="GLUTATHIONE_PEROXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY16563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="234" mass="25537" checksum="86F6B9A9025215BD" modified="2018-09-12" version="1">MSSATTFYDLKAPLPGADKTYDFKVSCLRVVVDLKGKVVLIVNTASKCGFTKQYDGLEALYKKYKGKGFELLGFPCNQFGGQEPGTDDDVASFCTLNHGVSFPLMKKVRILPNTAVYKPSALLTAGSSHLCQSDVNGDSTNEVFQYLKAKQPGIFGTTMIKWSVTVIKLEKCTHRAKLIGRIPIPHRNFTKFLVDGEGNVVSRYSSTTTPESIDKDIAKLIEGSALSPRAPQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NVF5</accession>
    <name>A0A2X0NVF5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C012g06920 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C012g06920</name>
        <name evidence="1" type="ORF">BQ5605_C012G06920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NVF5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16128">
        <property type="entry name" value="FAD/NAD(P)-BINDING OXIDOREDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16128:SF5">
        <property type="entry name" value="FAD_NAD(P)-BINDING OXIDOREDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY16596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="393" mass="42154" checksum="CA50F0B6ADFC38B4" modified="2018-09-12" version="1">MSTRATPHIVLIGTGLTSLTIARTLLLSTTLTTPFSLTLLDKAKNPGGRLTSRTYDSGVVLETGARVFEASPNPSTFIKEVERWESKGYVKQVVPGMLKGVGEGSSGSGRGGKWWEGVGGFSRGLIAGLVQEIKEASKGRVEFKYEVTVSGGYLQVVAANPTPIDPTTNPLDLTLDPSIELPPISYLVHTGPSPQSSVLLPSSSTARASPTTYLKTFVWLLPTIKLSPPSPIYHRNPHTSINSIATGLGSKSPSSKTDDDAQGLVIQSTPEKLGLGCTKDETTDQEIRNRFFKILSDENVLPLEILSDIKDRTGRESQIKRWKFAQVEGAVEVRQGGYETEGKRCVVLEGDRVILAGDGTVGGAGCVEGAYLAGVEAAQVLIRWVEQAERSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NVJ4</accession>
    <name>A0A2X0NVJ4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C013g07258</name>
        <name evidence="13" type="ORF">BQ5605_C013G07258</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NVJ4"/>
    <dbReference type="STRING" id="796604.A0A2X0NVJ4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="12">
        <location>
            <begin position="222"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="160"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGY15130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="844" mass="95613" checksum="A27818C1A7067416" modified="2018-09-12" version="1">MAKRIVPEVMREFDVKAGGTNPSPITFDELIENFEKKFVDPEYKGRAISELDSLRQRDNRGNYVRVRDIADKIEDLCESTNEQSEWQMKRYFIDAVDYKIAAAINRVMTWERDSVLLDHLVTVAAREEQSLLAERGAREAFQQGKKFSNYTALIAKPAKYTASNEQPNRKYQQQWRSQSKGEHAPREGQKQGQSTEQSPRDANGQPTGNARNGTRDMSKVTCHNCKKTGHYARNCRSRVESKMMAMEDSNTEIKVLASSTAMNDDDAQPANEAPIAPFTKYVSVPIKLEDQPGFNATIDTGASHTFIHPSLPKRLGVKMVRYPMPRNLKLGTKGSRSKIIGFCYLNWTIADLMTRQRFEIANIDDDVLGGREFLRKHDTVVELNPDRIIIRNTTGRSLRHNKAEAAKFDPKYVPTQAEIDSFQTYLFAEYSDVFVDDKAPLNLPPLRDVQHTIPFINAERADKKQRISYRFPDECMPAFDRCYKKHVEAGIWVPCAAERADPMIPNLKKDGEFRPLVDLRKRNLNTVQQDMPMQDADRMINEVANAEFASTFDLKGAFQQIRIDPDDEDKTPFMTPYGACYTRVAQQGDRNSTVSLARLIEHVFRDQLGRTMYAYADDTKIVSPSWGQHIRDTIEIAETARKHDLRFSREKSLIAPEARDTLGRKIRKGVISIESDKRNAILALPVPTNKKELQSFLGMVEYNARFIPMLMDDTAPLATLTGNVPWRWGGACSAAFEAIKQKLAQEVELATINAQNLAPYSSSPVHLTQPPHQNDVPSNAVKGQYLFLQTDASVEGVGSALLVGENWWNAKPVGFHSRKFSPAEFNYSTPDQELQAFYEASTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NX06</accession>
    <name>A0A2X0NX06_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C002g01724 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C002g01724</name>
        <name evidence="7" type="ORF">BQ5605_C002G01724</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF5 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY35074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NX06"/>
    <dbReference type="STRING" id="796604.A0A2X0NX06"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006939">
        <property type="entry name" value="SNF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10019">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04855">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="193"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="554"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="658"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="836"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="555"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="679"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY35074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1035" mass="112735" checksum="E671F22BA8883871" modified="2018-09-12" version="1">MNGHGPAVAPPPSAMDGSHQPRGGTRPSLVPLTTPGPSGSPSYHPAHPMAGPSSSNGLASGFETAVPGSTLLSAVPSASAMSLSATTMAQYSVAARQQARLAGNVPSPLPRTEPDDGGPPFKVPMHALFTRITVLEPGVEFPAIADERDQQRVKQWMQRDLDYERTNLYKKRARTLEAQSLFDEATVGQDWLGPRLANEGSGAKSTPSNRLRIKTEQERERERRSGKRGPHRKEVRMSKTQLREIAKSKECLVPIRLEIEHEVYRLRDTFTWNLKGTSIHSSNRRGSYFETGLIFASHLCEDLRLPYVHFYKEVVAQIKRAIEDAQMTENYDAYLADDLGLTRELNRRWFEEGQHKLIDEGELEARPDPDEPPEAGHSALDPMDEIIEMDYRQTIDHLDTKPSSDFVLGLRDGLGPAQKVSGVVKEKSDVPAHSDDYANEELRVTIQLDITIDSVQLVDRFEWDLSEAQNSPEQFAETFATELGLNGDFQTAICHSIREQLDVFTRSLCILGHTQGLTVADEELRRQFLTPISEPIRFESAADYTPLLNQLTPDEVDRNDKEREREVRRKRRQTKGRGVTLPDRDFVRTHRTIVPKSTGVPIISYQDARGETVYPMGEIGMPYPIVAPFSIEKPPDLEIHAASPLKLIQPKAQLGIDHTVDGKPNKNVLKRSLGDGLGHSTSGDGSGQTLGDAAKRPGGQGRGRRTNLEALGLHPHIIEGAWFCANCGVPDSIAVGRRKGPTGANSLCGQCGKFFHRYRRNRPCTYTTDLETHRHAKAALDAAAAAAKLAKNQAAAQARAAAAAAAAAAAAAAAAAAAIGDDATMASARLNMLSAASDRGGTATRDNSSDESGHDDDDSDDGSSVPGRSARPTPSNRSPRGPSPFVREGTNDSDLSSASDSPRRPTPSDVRTMSIGGKGIPPLPMHAPVGSPANLPRPAQSADVGPPIPPTWMHAAAAELRAKQIDDRFDIIPRPRPVDPTAVQEWRIRCLDCPGKLYNVGPGETLDNFSVHFKNRVHRGNVEARLKGLPPPPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NXC1</accession>
    <name>A0A2X0NXC1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g01846 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C003g01846</name>
        <name evidence="1" type="ORF">BQ5605_C003G01846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY37627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NXC1"/>
    <dbReference type="STRING" id="796604.A0A2X0NXC1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY37627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="442" mass="46694" checksum="96C4FCB97A49DFB4" modified="2018-09-12" version="1">MSHRHLTFTADRSRPPLHFVVPTNFQSISLLSFSSTSLISATALPAGIDRRITENSAFQERVVITCNPGFIPTANGYVCNASQCPNATSGVATCTVPGSCTINSNGGFTTVGNTCLCDADECPHITNGVATGTVPGVPSSADFTCNSGFNKQSGACVTAAYLYDLAPRSLPLASTCFHEFLSLSLGFPATINRASINLQPPRPLFWSYKNNYINPATRPAILAIACCLRLSNLNPDTPCLWTSDESPACVASACSNLANSVSICTSSEACDFTCNTGFNKQGGACVAIPSACNKKSVAPFQNLQMTKNGERAVTGGLVLPPFGRPFHTLALSLFWAGSVRLTKVAGPAARSPEPTGSALLSLLLKRLLGLVSLVRRSEPYHRLSRRHVFIGYSPTSYQRGDADGFIGVGRRHAGPCEMRGGAERGGADTKVTALVACWADNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NYE9</accession>
    <name>A0A2X0NYE9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C014g07641 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C014g07641</name>
        <name evidence="2" type="ORF">BQ5605_C014G07641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY19415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NYE9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY19415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="481" mass="52706" checksum="BB4E0007DA2B4724" modified="2018-09-12" version="1">MPMPQTPSSDSDSDEPNLGDSSQSSADDSDSESDSHSHSESEFEDIAIDHRRAIRLWTAIHGSHRNATGRMSQRKWTSLKRWAARRYYSELKMAAKLGISHARLVQAVKKFDRLASKGNAWSRFLSDPVIKSKSQSITKLAAHLWNFLRDQGDLASAQLGEDDEELVRAAFAAAEAGGNTTFTSIVPPTIITRSPSGIPSSTRMEQSKMETLAFIVPRYQDDVSPATKATVHSIGGLRFAAHCNDFKDPSGNSLLSNFASKMSWDETLKANEAADLKEGEPFIASYTRMRPSYRYQLCDICFRLIYQQELARWTVLLVAFLANDTALYSALETIHRRSDTGSSTGAFTPQKKMIWSTQGLKALGVKLRIKPGTKSRYEMALHHSAETSPKRTVAQLKAIIDDLRHGRLAIVPSADPNDNTEAEASNNDLNGGEGPLSPRFGGAGDEGGEVRGGEKSGEEDREKNSGGGGGGGGWRRRPEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-07-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P4Y5</accession>
    <name>A0A2X0P4Y5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C004g03001 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C004g03001</name>
        <name evidence="3" type="ORF">BQ5605_C004G03001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY69348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P4Y5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052413">
        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF2">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015947263" evidence="2">
        <location>
            <begin position="20"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY69348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="265" mass="28145" checksum="BD7F9A4B183625C1" modified="2018-09-12" version="1">MVRLNCCAGFGILLAVALRERKCPIGGQIAQLNPSTIPRHLRIVTITTTGLAAALGNVNDLYDTASGYVGGRSVNGNNQGLRQTYEWGIWNYCTTGGSIGSQRSYCTKRSFGFEFRPALALLGDVPTQYEQALDAALPNNVFSDDKYLGRFTKVANYLVFIGSILAALAMLVGFGAHRFAFLFGAIVSLLAFLLLAAGAIISTVLLARVKAAINNATISGVALGVKVAYGNALWLLWGATAAAFLAVIPYLIACCTGRNDSSNDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P751</accession>
    <name>A0A2X0P751_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">BQ5605_C001g00826</name>
        <name evidence="23" type="ORF">BQ5605_C001G00826</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="2"/>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY49846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000007">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08284">
        <property type="entry name" value="RVP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="13" id="KW-0229">DNA integration</keyword>
    <keyword evidence="17" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="15" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="14" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="21">
        <location>
            <begin position="697"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="22">
        <location>
            <begin position="1241"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="20">
        <location>
            <begin position="1554"/>
            <end position="1612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="79"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="SGY49846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1615" mass="182091" checksum="7EE4AED7EDAC46C7" modified="2018-09-12" version="1">MIRLGLSRTVGGGVVWRVICRTSGKGTTSGPCNMHQRFAGSKGEPRGTTPASCKARAPGPYEKGARAWTLLVSPQRLTRVSRRTLPRAPATPLRNERTNKNERTTTTMARAKKATAQPPPALQPDEPGSSDDEEETAMMPKGLKLNAPKLASDTTLTLAPVRAYLNDMDNLFTQYKVTGMRFKVMFITHHIEQEWLKDWCGSATEDRTWDEFKVAFLRKALPLDFAYATEKAIRHSKQRLTDYTSWASGLRASQLQLGQAAFSDTSFIKVLLFNMDPQLSVILRQDDLLLNTGMHTDDLDYVVASKTALPKPKTISYEAFERLARSKWNMITALRGVAAPRTHNSTMATRTSSYRPPATTSTGGRRLPAKLTDAMKDYLSLKEGCFSCRRIHTDHRSKDCTAEWQKAPDVPEGWTEFEKRKASAAKNDTLHQMAEQSEDDLSTDEENEYAPQFISTIPITLHNGKGSQTLHALADSGASSSFIADKVVEKLGLAVHRLPVPTMVKTAIKGQKRAFHVTSYVKIPIALENGTWEAGDTILKVAKLQEPLEVVLGFNFLAKHKFNIDFARHEILVPHPSMPNVMIDLLAPVFGPQSQRAVPRSPKRSDKARINWGAVIAYIDGVQQKESELAELRAREARLRVEFADRFPGDIPPVSMYESPVRHRIELKPGAKKPNLKGYRAPHRYRAPWKRLIDQHVTAGRLRKSSSEFASPAFVIPKKGMDKDPSIQPRMVCDYRVLNEGTVRDRTPLPLPDEILSICSKARFWGKIDMTNSFFQTKMAEEDIPKTAVITPWGLFEWTVMPMGLCNAPATHQRRVNEALGDLIGNVCFVYLDDITIFADTLEEHERRVRLVLDALRRADLYVSPKKTELFAAECFFLGHQITREGIKVDPDKVQRIQQWPRPTTVRQLRGFLGLVQYLRKFIDKLADLTAVLVPLTRKGAHVDDGWTGEHNTAFEAIKALVGSLPSLHPIDHSEQGDPLWLMTDASNRGIGAALSQGKEWQTAMPAGYWSRQYNPAEGNYAAHEMELLAIVEALHHWRADLLAVRFKILTDHHSLAGFMKQPSLSRRQARWTERLADYDFEIVYVRGPENTVADALSRYSFPEDCATRGASDDVNMLAEATLDPAFLKALKDGYLNDTHCQQAIKNIDSTPGYSYKDGIARFEGRILLPKTGDFRENAIHDAHDATGHFGLHKTYERLRRDFIWSGMKESCKEYVESCSVCQTMKMHGTGFAGRIHNLNVPDRPMREVGLDFVGPLIPSNGNDELLTVTDRLSGYVRIIPCRTTDDATTTADRFFDGWHRYFGMPRVLVSDRDKLFTSEFWRAYTGRMGTKLAMSTAFHPQTDGRSERTNRTVIQVLRTMVNRRQNDWSKHLATVEFVINSSVNRSTGKTPFEVVLGFTPELTPIAPVYGSTVSQAVESIMEQRETAVAEARDTLAIAKIRQADQSNKVRKLEPEFAVGDRVLVDSRDRRLRYKADGEARSAKFFPRFDGPYEVLAARPETSNYKLKLNAGDKSHNVFHASKLRHWTDNDGAAFPGREATEPASVVVQGNEEWEVDRIVDEKGKGKRKRYLVKWKGWADSDNTWEPRAHLEETIALEEWERERAEGERGKEGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P773</accession>
    <name>A0A2X0P773_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00945 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00945</name>
        <name evidence="2" type="ORF">BQ5605_C001G00945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY50975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P773"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY50975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="94" mass="10671" checksum="31B4EE1337B9BF83" modified="2018-09-12" version="1">MPSKDLPPFGACPACEMPPAEPLQAAQMPPRKQGAQFQQKGSLTTKQRASQQSKEGLFEAWSHAQHQPKRRAPRATFDRPPRARKRSERVFEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P7F7</accession>
    <name>A0A2X0P7F7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C008g04974 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C008g04974</name>
        <name evidence="2" type="ORF">BQ5605_C008G04974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY78855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P7F7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY78855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="300" mass="33501" checksum="BBA8D3BD33740A77" modified="2018-09-12" version="1">MSRSTVEEHSYDRSRSDASHPRIDWNRPNWARQSRSRTKGFGARACAAFSSESGVETVHPELYWLVRMLDGFDRPSDLQEVWEALPVIVPTPLSYALAYAYRCVRNVCSYIPWVCQTCSESNQSKSQSITKLAAQLWNFLRDQGDLGAAQLGEDDEELVRAAFAAAEAGNNTTFTSIVPPTIISRSPSDIPSPTRMEHCKKYMAQRMSKLYGVETLAFIVPRYQDDVSLATKATVHSIGGLRFAAHCNDFKDPSDNSLLSTFASEMSWDETLKANEAADLKEGEPITLGMGDYDLLQFDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P7X6</accession>
    <name>A0A2X0P7X6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C006g03922 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C006g03922</name>
        <name evidence="3" type="ORF">BQ5605_C006G03922</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY54871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P7X6"/>
    <dbReference type="STRING" id="796604.A0A2X0P7X6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF440">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="178"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY54871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="694" mass="77476" checksum="56F4EB87AFE01833" modified="2018-09-12" version="1">MMNKFYKKKDGGDGRRRLRHPSDDADNNPPDPNQIPDGYEPVVPTTERTSELAERWGAPAGSRRRGGAEQQAMFVDVGTILGDVILLNELPEWEQVLNVVVNLEECNDWTNLSSIVQGSTEGISGLEELEAYQVWTGSPDEPTYKQAMAGEDREDWSISLMTEYSILNGMNTWDKEATDPPPGVRAIPTKVVLVRKRNDKGDIIKYKARIVARGDLQNHHGETFSPTARIASIRMINIIAHVKGYRRLQFDVNSAYRHGHIAEPLWIKLPDGSTHRLRKSLYGLKQSGREWNKVLHLHAALVDRGFKQMEEDFGVYRRVRNIGGVDRTTLLAIYVDDGASRVSSMPRARFLSASLLSPTIFTIIFGSRTYAPRASASVPKNLEGFLSEFEQQFNFKRGEVQLFLGMKITTDDASGIMTIDQCHQIESILNNHGFANASAVATPTSDSDQHSDGGTAHLKLNYRQVVGELLWVSGCTRPDISYAVTQLSRHCADPKPEHFRQMRRVLRYLRGTINRRLEYNRHLGIDVTLYCDSDHAAEKSGCRSISGYTVIMAGSAITWASKRQVSLATSSVQAEYQALSAAAQETLWIRSLLFSLGVPPSSPTIIHGDSTGAIALADHPTSHATTKHIATHCHFTRELVSNFIIELRWIGTKEMVADGFTKGLLRVPHQSFVRMLGMVDAPRQGACWKGLREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P865</accession>
    <name>A0A2X0P865_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C008g05294 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C008g05294</name>
        <name evidence="2" type="ORF">BQ5605_C008G05294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY80053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P865"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY80053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="203" mass="23797" checksum="4C2509E59AC2608E" modified="2018-09-12" version="1">MNQYLNTSMCRHPLRTNLFTHGSSLKKLSIFQPLQDKPTLSFQQATTLKSWESSDDFLLSKLCGHTSIHSQSRSRRFLCRARHQDFSGRRASQKLAQSIQQQFSMRPVFPIHRLEHAPPATRRLFRQLAFRVPKEKLRWLGSQQHCSKMDVWAELTPKKSRARKGTGQQQKQKQRRISTCRRIGSEYMARNKAFFTQVTHTIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P876</accession>
    <name>A0A2X0P876_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C008g05314 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C008g05314</name>
        <name evidence="8" type="ORF">BQ5605_C008G05314</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY80156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P876"/>
    <dbReference type="STRING" id="796604.A0A2X0P876"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SLC26A/SulP_dom"/>
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        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="7">
        <location>
            <begin position="538"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="702"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="SGY80156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="772" mass="83750" checksum="0BDDE1C722672AFF" modified="2018-09-12" version="1">MATIIELPQQKTFKEKAFAWLGHDPIITETASTRDALASASSDLPGAAAHYVDRLFPFTKWILNYNLGWLTGDLIAGLTVGMVVVPQSMSYAKIATLPPQIGLYSSFVGVMIYWLFSTSKDVTIGPVAVMSLEVSKVIKHVQNSPTGKQYSATEIASTLALICGIIVLGIGGLRLGWIVEFISAPAVSGFMTGSAISIIAGQLAGLMGYSNKFDTRASTYKVIINSFKYLPSTKRDAAYGLSGLFFLYSVRAVCNHYERTGRTYTIRRTAFFVGTLRTALTIIFLTLFAWVHLRHQKPANYDISILKTVPSGFQNMQVPRFRTGLISELGPLLPVSTIILLLEHIAISKSFGRVNNYKIDPNQELIAIGITNVFTPFFGGYPATGSFSRTAIKSKAGVRTPLAGVITGIVVIIAIYGLTGAFYWIPNAGLSAVIIHAVGDLIASPPQVYSFWLVSPLEAIIFFGSVIITVFTTIEIGIYASVAASAALLLYRIAKPRGTFLGRVRIHSEDNNITREVFVPLNKDGVHNPYVKVEAPPPGIIVYRVEESFLYPNASRYVDHIADYAKETTRSAIDYDSLSLSQRPWNDPGPLRFSKKKTLAPGQLSATDANAAKPLLRAIVIDCSGISNIDSTSVQNLVDLRRVLERYSGQEVEFHFASILSPWIKRALLAGGFGRGRGSQPLEIAAVVPAGTEAVIERYEKHFPSSPPNGRIPSDDSSSANSKVPDIEEAGGSLDQRLGEHLTPTGPLVSALTNRFHLDLAAAVAAAAGREW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P8W2</accession>
    <name>A0A2X0P8W2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C009g05605 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C009g05605</name>
        <name evidence="2" type="ORF">BQ5605_C009G05605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY82943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P8W2"/>
    <dbReference type="STRING" id="796604.A0A2X0P8W2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY82943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="154" mass="16323" checksum="2942DFB1AE13D84A" modified="2018-09-12" version="1">MPTLLCTGCSSGLGLQALRHLYSHVPSTTSPASPSWRLIIGARDVAATQARLATIVPSQIPKPHVLHLDLESFESVRTFSDQVKLLVEGSGAESTPEPSRARTDAPDRHQGGIQCILLNAGVYTAKFEALSGGWCKEAIVNTFGRSRNGSAGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PB80</accession>
    <name>A0A2X0PB80_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C004g02916 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C004g02916</name>
        <name evidence="2" type="ORF">BQ5605_C004G02916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY68748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PB80"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY68748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="144" mass="15159" checksum="98C153CD4B095E00" modified="2018-09-12" version="1">MCTPLRNGKAPSSTLLGTPLPPRERSTGAPSPSPSIMSRHNKSSIVNGGTSPFGRGTSMRRFNISTPHPDSTTAPASPTPTATATSTVAGSDYAKSIIEHTTPTATPARRPTASSAPIRIVADPSIATTFRKEEDPELYDLFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PDW5</accession>
    <name>A0A2X0PDW5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">BQ5605_C008g05129 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C008g05129</name>
        <name evidence="14" type="ORF">BQ5605_C008G05129</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the polysaccharide monooxygenase AA14 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PDW5"/>
    <dbReference type="STRING" id="796604.A0A2X0PDW5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055826">
        <property type="entry name" value="DUF7402"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054497">
        <property type="entry name" value="LPMO_AA14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24135">
        <property type="entry name" value="DUF7402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22810">
        <property type="entry name" value="LPMO_AA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="DUF7402" evidence="13">
        <location>
            <begin position="547"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="294"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="468"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="712"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="294"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="469"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF24135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGY79428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="765" mass="80770" checksum="959B84676BBA8C28" modified="2018-09-12" version="1">MASSTVAHMSIWTTSMYGVGWHGTGTPFNTQEGGYFSYDTVDPVAPLGPDWSNQDDWWFRGPAARALKPSPGSVEKLPAGGQWTVQIACHVAWTSYGVSTTTPGSLLDACPGNPGAYHSGDPAATDIDRNLLSGCALGIADVDDISKVTIDNLAIFSVKHSCVAKKFNTFDIPAAMPACTGKKCICGWFWLANNGTGNFYMTAFDCAITGAKADALPIAAPKDPVWCAKKDTACMAARPGGAKRPLYVYNSPSNIVWKGNDDRPGYHANWGFPNDGAQNDIFVNASSVKSSSAGASLPTASQASPTTAAATPTSPAASTPASPAPTNCAPSGWSSKGLGEDGYDCDSTGATIPYVAENLMDSNGKWQYYGVKYGWQPVSGEICFGAVTRTLRFVLTLRPNVTHLQSEAWNIPSANWVPPTQWTVTEALKAKWWSPASSWLYPSNWDTSKLLPMWGNLNSNYIGPYEAGSTPSPTASPTTKSKTTTTSKTTKTPTTTSTTTTAKAYQSSSTGAVAVGATTATTTTTTTTSTTTSSAAPVQTTAAAAVNLALQATASGSSYRSGSEYSKLIDGNTQGLNDKGAGSVRVEWISRSQTVGAWVRLTWKSTQTFNQVVLYDRPLSSEQITAGVLIFDGNLQVPVGSLNKDGAATTINFTPIQSKTVTFFVIGTNTAASAVGLSELQVFNQASTASLTRVMTPQKRDVVNDFMDAFNEPAQPAGTRHPRDFKSASIAQRSPSPLVAEEDSLAKRCGGMDHSCELTAEKLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PFG7</accession>
    <name>A0A2X0PFG7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C009g05499 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C009g05499</name>
        <name evidence="2" type="ORF">BQ5605_C009G05499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY81455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PFG7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015962798" evidence="1">
        <location>
            <begin position="23"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY81455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="146" mass="14559" checksum="294BC04470C1652E" modified="2018-09-12" version="1">MKFSARVQALFLLGALQTFVSATATPQVDSVTVERSLESVPSTEAVEKRTLLVGAGPVLAAGGVVGAALNTAGNIVNGVLGGVLGGPVIGSSVGINAGAYVGGGPYVATGPGYSSYESQSYGVGPGCKKKFVKVRRTAQVEEVESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PGX3</accession>
    <name>A0A2X0PGX3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BQ5605_C034g11267 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C034g11267</name>
        <name evidence="11" type="ORF">BQ5605_C034G11267</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000065">
        <property type="protein sequence ID" value="SGY99109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PGX3"/>
    <dbReference type="STRING" id="796604.A0A2X0PGX3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11371">
        <property type="entry name" value="RNase_PH_MTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF2">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT MTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="10">
        <location>
            <begin position="45"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY99109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="323" mass="34303" checksum="1AA99ABDA52517C7" modified="2018-09-12" version="1">MQTADRRRFNGPEGARPPRFNKTASLDQANDAASTWRQDGRTPSQIRPIFMQTGLVSDASGSVYIETGRTKVICAVHGPKPTAPSVAFSPRARLNVEVKFAPFSSGIRRFAPGKVRTELVDAEQILSTRANIDTLPSLTQDTESLTLSSAVHQAIIPSLLLEALPKSQIDLFLTILESDGNDDDIAAQVSKKSGITAASVALAKAGIPMRGLVVATSAVSKPPSSSQPIPELLIQPTLYIAQALLSRCPTQAFFDPALAEARNSIAFATIACLPALGTITSLTTTGSFPMIVLEETLETAVKICGQLHGVAKQALLDDSNEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PIY9</accession>
    <name>A0A2X0PIY9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C040g11868 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C040g11868</name>
        <name evidence="7" type="ORF">BQ5605_C040G11868</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000118">
        <property type="protein sequence ID" value="SGZ32406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PIY9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF117">
        <property type="entry name" value="SERINE PROTEASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015979747" evidence="6">
        <location>
            <begin position="31"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGZ32406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="695" mass="78019" checksum="6761021AAC731042" modified="2018-09-12" version="1">MASRSQGPRMHQTLFSLLVFVALYASSAFAGLTSHTLLRAPSVPVQLLQHVQRAEQAQITTHQSPFIVSGDAAVQLAPTDEPEYQAYTFDQLVSHLDSVPAPVKGQTFKQRYWMNAKHYKRGGPVFLLDAGETNGEERFPFLRQGILEILSKTHNGIGIILEHRYYGESFPVQNLTTDSMRFLSTEQSLLDAKNFKLNGKLPGVAEFSNNLSPWIYYGGSYAGAKAAFARKKYPSTFWGGIASSGVIQPIINFHEYYEPIRKSAPQECMKLLITHTNIIDQLLDLNDYTVTSTLKGLFGLPNVTRSDDFVSTLALPLGSWQERNWDPAVGINDFDIFCNALTSSEHEPILPGQAAVLQPQIKKITWASATELDDLAKYARYIRTQVASSCPVGVSQNDCFSRSSGWNATGLDQASWRSWAWQYCTEYGLFVTSSPNASRRLVSKRINLKYSSEICHGAFPPGKLVSMPKTPQIKRIEKYGGFAMKGSRLAFVDGSEDPWLYATRHSPHAKKRPDTLSGPYKLIEGGVHHWDENGRPKGEPKIIREIHADEIKFVGHWIDQWNARDPLRPFSPSCADLPSSPPLIPYLPPHPQQGTPYHRYTLVLLEQKKELVLAPEAVERTDFSVRDFMRQNDLTASGMSFFRQKWDEDVSAIYREILGRLTVRCGRTSGTEPPRFARPPKIDTYAGRPAKYGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PNX3</accession>
    <name>A0A2X0PNX3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C051g12542 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C051g12542</name>
        <name evidence="1" type="ORF">BQ5605_C051G12542</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000096">
        <property type="protein sequence ID" value="SGZ29574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PNX3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ29574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="36" mass="3969" checksum="B4818C7AC0948C88" modified="2018-09-12" version="1">MLPPPCNPGCWMARGLAQHGGWCGLQHVHLSEKKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PPI9</accession>
    <name>A0A2X0PPI9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C041g11955 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C041g11955</name>
        <name evidence="9" type="ORF">BQ5605_C041G11955</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000119">
        <property type="protein sequence ID" value="SGZ33315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PPI9"/>
    <dbReference type="STRING" id="796604.A0A2X0PPI9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="25"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGZ33315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="586" mass="64820" checksum="AC214842BD7749CB" modified="2018-09-12" version="1">MTDDVVDNTRRNQANTSKRGRATLACLTCRRKRIKCSVSGLKIPNVSILPSAGEQPTCGPCRSLQRTCEWSWEDKRKPYTKDVVDALKQQIANLESKLAELSTIGDASLGPRPNFNEISAAATLSSLAPGTNEVSTASHPRTAGGLARNAHGELRFFGPGSTHILMAQSAANQQSLEQSAAQILTRAPNPRIANSLAIPPRPPELDLVFRARLLRLAFDYALPLFQVVDERRFLSELNAHPDDRTDAYSPFMLNILLGIGCRYLDPEEDFPREVCSDPNDPSTKGDVFINYARFCLDSEWNWPKISTLRGLVCLALYLTGRGMDGLAWLYTGMSSLVAENFGLHLLIAHLPNAPATVDDELVMARRDAFFAIFSNEVLLAMHIGRNSNFRPDEFDQVPGLIDPSADFDPPLYRSSVFHWSSRLATVANKILSHVYVKRGEALATRKQEVPSLHLELQTWYHALPSHIKVATSDTVKTPSPLLIACFRTEHCLLAYTAVPPSPLFLSFRWSCNRHTLFNREMFACGLPHCSTSESPAEMSRCSVCAPSVCASVVFRWDYPSTLINTARNFSNASAGQRAPRALCKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PQ19</accession>
    <name>A0A2X0PQ19_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C043g12058 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C043g12058</name>
        <name evidence="2" type="ORF">BQ5605_C043G12058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000117">
        <property type="protein sequence ID" value="SGZ32039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PQ19"/>
    <dbReference type="STRING" id="796604.A0A2X0PQ19"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058913">
        <property type="entry name" value="Integrase_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791:SF5">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24764">
        <property type="entry name" value="rva_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase core" evidence="1">
        <location>
            <begin position="107"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ32039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="362" mass="41671" checksum="39849A2A42116366" modified="2018-09-12" version="1">MLVGFSSFVTSVRTAHEQNLGTTQIAKLFGVSRWTIRKAIVDQQVRQPFERTRVRTLLPDAELDRLVMEILDHETSLGEILVGASIQRTRPLRRHVHANHPVMRRRYNVAGPNALWHHDGQHALISFGIVIHGFIDGYSHVLAGVRASSNNRASTVLSVFQDAIALYPNVQVAAMMEAVRGLGRGSYLWGTSPHNQRIERFWRALKKSVLNAWLHRFRHLEDEHGLNIELSRHVWLLEFLFLDDINKDLAWCQDVWNNDKLRTEQRSTPNQLFWSGSIQNGGRGIYDENLHIPESTEQAGNENNNMFGEEVRSHVDLHSQRSPFLNNPEGLEALQRRMTERWHASAVDRWLEGLRAMEQLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PQG0</accession>
    <name>A0A2X0PQG0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C072g12885 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C072g12885</name>
        <name evidence="3" type="ORF">BQ5605_C072G12885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000123">
        <property type="protein sequence ID" value="SGZ34288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PQG0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08284">
        <property type="entry name" value="RVP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ34288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="657" mass="73824" checksum="39A8D2CFE53F8EC7" modified="2018-09-12" version="1">MARAKKATAQPPPALQPDEPGSSDDEEETVTMPKGLKLNAPKLASDTTLTLASVRAYLNDMDNLFTQYKVTGMRFKVMFITHHIEQEWLKDWCGSATEDRTWDEFKVAFLRKALPLDFAYATEKAIRHSKQRLTDYTSWASGLRASQLQLGQAAFSDTSFIKVLLFNMDPQLSVILRQDDLLLNTGMHTDDLDYVVASKTALPKPKTISYEAFERLARSKWNMITALRGVAAPRTHNSTMATRTSSYRPPATTSTGGRRLPAKLTDAMKDYLSLKEGCFSCRRIHTDHRSKDCTAEWQKAPDVPEGWTEFEKRKASAAKNDTLHQMAEQSEDDLSTDEENEYAPQFISTIPITLHNGKGSQTLHALADSGASSSFIADKVVEKLGLAVHRLPVPTMVKTAIKGQKRAFHVTSYVKIPIALENGTWEAGDTILKVAKLQEPLEVVLGFNFLAKHKFNIDFARHEILVPHPSMPNVMIDLLAPVFGPQPQRAVPRSPKRSDKARINWGAVIAYIDGVQQKESELAELRAREARLRVEFADRFPGDIPPVSMYESPVRHRIKLKPGAKKPNLKGYRAPHRYRAPWKRLIDQHVTAGRLRKSSSEFASPAFVIPKKGMDKDPSIQPRMVCDYRVLNEGTVRDRTPLPLPDEILSICSKARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LQ45</accession>
    <name>A0A2X0LQ45_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">NADPH--cytochrome P450 reductase</fullName>
            <shortName evidence="19">CPR</shortName>
            <shortName evidence="19">P450R</shortName>
            <ecNumber evidence="19">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">BQ5605_C010g05960</name>
        <name evidence="23" type="ORF">BQ5605_C010G05960</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="19">This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="19">Binds 1 FAD per monomer.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="19">Binds 1 FMN per monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19">Endoplasmic reticulum membrane</location>
            <topology evidence="19">Single-pass membrane protein</topology>
            <orientation evidence="19">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Mitochondrion outer membrane</location>
            <topology evidence="19">Single-pass membrane protein</topology>
            <orientation evidence="19">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Cell membrane</location>
            <topology evidence="19">Single-pass membrane protein</topology>
            <orientation evidence="19">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the NADPH--cytochrome P450 reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="19">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="19">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="19"/>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LQ45"/>
    <dbReference type="STRING" id="796604.A0A2X0LQ45"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06204">
        <property type="entry name" value="CYPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000100">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000024">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000018">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03212">
        <property type="entry name" value="NCPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023208">
        <property type="entry name" value="P450R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000208">
        <property type="entry name" value="P450R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 19" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 19" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 19" id="KW-0274">FAD</keyword>
    <keyword evidence="3 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 19" id="KW-0288">FMN</keyword>
    <keyword evidence="2 19" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14 19" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="15 19" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 19" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9 19" id="KW-0521">NADP</keyword>
    <keyword evidence="12 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="20" id="KW-0732">Signal</keyword>
    <keyword evidence="10 19" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="18 19" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13 19" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="17 19" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016159521" description="NADPH--cytochrome P450 reductase" evidence="20">
        <location>
            <begin position="27"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="Flavodoxin-like" evidence="21">
        <location>
            <begin position="72"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="22">
        <location>
            <begin position="280"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="78"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="134"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="466"/>
            <end position="469"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="484"/>
            <end position="486"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="502"/>
            <end position="505"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="573"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="644"/>
            <end position="645"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="651"/>
            <end position="655"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="688"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="726"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="SGY13741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="727" mass="79851" checksum="6081F090EB417201" modified="2018-09-12" version="1">MAIPISQVAAALLVILVAAWFFSSQSLDAGASSSSIDKAGLSNGGASHAAAGDEESSGRDFVAAMLKAKKKIVIFYGSQTGTAEDYGTRIAKEAKSRYGLSSLVCDPEDFLDGRYDFETLDQVPEDALVVFCVATYGEGEPTDNAVGLMDFLKGDTIELSKGGDSLENLNYVIFALGNSTYEHFCAIGRQIDERLSKLGAKRVGELGEGDDDKNMEEDYLSWKDGMWEAVQKQLGWEEGAGGDVADFEVTEKSEVDEAKVFLGELSHRALTGTRGVFDAKNPYAAPILEAKELFEDGDRNCVHAEFDISDSGVRYQTGDHVGVWPLNPDAEVERWLRILGLSDKRDQVIDVKSLDPALAKVPFPVPTTYDTVLRHYVDVSGLASRQTVGSFAKYAPTEDARRLLEQLGSDKALYQAKVGAPCYKTSQVLLLAAGDSLTADPASANYKQWSIPFDRVISSIPRLHPRYYSISSSPKLYPTAIHITAVVLKYQAVKGDPAYSYGVGTNYILNLKVAHTGGARTSREEGTPVYKIEGPRGKYKKGSAFCAPIHVRRSNFRLPTSPKIPVVMVGPGTGVAPFRAFIQERVALARKAKEKDGADALKDWGTIDLFYGCRRSDWDFLYKDEWKAYEQELDGKFRMHVALSREPNQPKVYVQQLIKDLGDHIGDSLVARKGYAYICGDAKHMAREVEDIFEDILGKAKGGSKAEGARELKLLKDRNRLLLDVWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LSG5</accession>
    <name>A0A2X0LSG5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C012g06838 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C012g06838</name>
        <name evidence="3" type="ORF">BQ5605_C012G06838</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LSG5"/>
    <dbReference type="STRING" id="796604.A0A2X0LSG5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF115">
        <property type="entry name" value="BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="2">
        <location>
            <begin position="102"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY16305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="199" mass="22149" checksum="828A67F0BE9A3B75" modified="2018-09-12" version="1">MSSFLQQASPVTQNLSNLSHPVQRTLARLADNFNAWLVDHQLFVAIQIVVLSGLFFWYITLPVEPTPIPDLSDVDPGTKMAAAVKPFSTDDIKLDPPKDDPITVEELKQYDGTHADKGIYVAIKGTVFDVSAKKDMYGPGCGYHIFTGKDASCALGKSSLKIEDADPDYSKLNEEEMKVLDDWFKYFAKRYNIVGKVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LSY7</accession>
    <name>A0A2X0LSY7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C012g07008 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C012g07008</name>
        <name evidence="3" type="ORF">BQ5605_C012G07008</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LSY7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.700">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013262">
        <property type="entry name" value="OMP_MIM1/TOM13_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28241">
        <property type="entry name" value="MITOCHONDRIAL IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28241:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="604"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="667"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="774"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="341"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="32"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="83"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="619"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="669"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="688"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="777"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY16849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="927" mass="97962" checksum="2B1B0B9A5706136E" modified="2018-09-12" version="1">MSNPASASTPSNSSLNSKMPGSTPTVAYAIASSSPTSSPKSKSTSTLTHPSSRTAHSHIPSPSNSTPSPPNLISSDPKKRRVSTAAASASASASSSSSAIPSSPRLKAPSSLIPVASSSSITSSHDPAGSTIGTTNTTSTSGSKNKKKKKKKTAAARTSTLSATAIEFDPTSATTAKVEEAEMAKKVEQEVLNAEAPRFEPPVEVVRRVEEQEEELHLKEQQQQQKTAEEMEVNKVDAPVEENKVEEDKIEETALVEETKPDEVQAEATPELSEAAEEVRKEAEVETEQVKVDVEPETEVDLPAPEPSTTEVEAETAVHEAEAKQVEEAAVEQANSEAPIIEKTKQQVEELAASASETAQAAKEHVSTIAEEVVERAEVQVEQVVEQASEVTEAAVDKTSEVVQSAKEVVADSIETAQNVVSDKVSQAAEVAEDTYEKTKEVVSDAAEATKEIVVDAAETTQEVVSESYKMTQQVVSDSIETTKDVVSDAVKQTQEAVSEAVETTKECVSGAYDTTKDVVSDSVEKSIEVAEEAKNNVIKGTQSLVENVSTAVQSVVPPVEETRIVEQDVSAPFQVEKEIQASVVPSSKSTDLLISAEEIASARATSDRSQDRIPVSLPSVSDLTSSTGIPETLDGDEMPLTAEQVIALPSLDDLLDVDEVEPIKVEVEEKEVEEKEVEEKEVEEKEVEEKGVKEKEVEEKEFEEKEVEKNAGLSASALQEHLAASGSEAEVVDTPIAPISGENSAGSADESASTLPATTNDAAVPSALGGEIGEMLTSNSAPPSSNGDDDDDKKDPSHQAEDAPSLTLTIVNTWKTTPWAAKLPAILASVVINFGLPFINGVMLETDSFRASSGFGELFARNFIGARMGWGNPYRAQGLDTRGGRANTAGVGLRAAGPSKIPPGGAGKRTAIEALEVEAMNVAREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LT88</accession>
    <name>A0A2X0LT88_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C011g06412 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C011g06412</name>
        <name evidence="1" type="ORF">BQ5605_C011G06412</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LT88"/>
    <dbReference type="STRING" id="796604.A0A2X0LT88"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY12168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="198" mass="22265" checksum="839A4FA96AB1860B" modified="2018-09-12" version="1">MGTLGPRVFRVFGRLYYRLGTLIPAVNQRPAFAQTWLIDPAEATDTRLGPDGADSHMQRSTLTKLESMLRTKNHFVREFASAKPRAGWDTAKEWILRLCLPPGRDRRTHNPPTSSTEMAMLIYDSDTNTGNRGPQDLILQVHGDRCPDGRPKYQVVSSLHPSPMPLRYPLLFPAGEDGFHPNIPLCGFHQARPPIARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LTE4</accession>
    <name>A0A2X0LTE4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C011g06472 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="26">BQ5605_C028g10577 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="27">BQ5605_C040g11905 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="28">BQ5605_C072g12892 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C011g06472</name>
        <name evidence="26" type="synonym">BQ5605_C028g10577</name>
        <name evidence="27" type="synonym">BQ5605_C040g11905</name>
        <name evidence="28" type="synonym">BQ5605_C072g12892</name>
        <name evidence="25" type="ORF">BQ5605_C011G06472</name>
        <name evidence="26" type="ORF">BQ5605_C028G10577</name>
        <name evidence="27" type="ORF">BQ5605_C040G11905</name>
        <name evidence="28" type="ORF">BQ5605_C072G12892</name>
    </gene>
    <organism evidence="25 29">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 29" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000080">
        <property type="protein sequence ID" value="SGZ13569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000118">
        <property type="protein sequence ID" value="SGZ32707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000123">
        <property type="protein sequence ID" value="SGZ34337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="416"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="656"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="759"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="665"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGY12337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="SGZ13569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="SGZ32707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="SGZ34337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1303" mass="142221" checksum="64E0057881D2C771" modified="2018-09-12" version="1">MSNPAISTRHATCATREAGRNGSTTSKPNARTDLEHANFQAIALLRRSVSLNIKKQIKDGFDHTPTDVLKMIKKAVAAGTVTDIFIKLQALLDAGPPPSGVDAFEKYQANTIELFNTLSGYNLTFDQVISIRLIHFGKDLYKEYYTQALRQDLDKLPDPIEALQTLQTQAESTPAHKPVAMVASLTATDRSSSTPSAPCRHCGGPHWNRKCPVKDKKSKASSAPSASLAAAPDISTLVDGPVRGYLTAAMSTLAKPSLILDSGATHHIVNDRACFTNFRKCKPAPLEGITGEAVNSIEGVGSAVVRSFDGSIGQLHHALFVPSAPVSLFSASRANAAGYDINLSRGKATVSVDGSICHTGEITNGLYHMHASLVDVTTLIEQPVNMEVALNEDLKCDTCQAGKITHHPFPTVASNRSAQPLDRVHMDLLAFDGAVSLGGAKYALVIVDDYTRYLWAIPMSHKSDTFAAFKSWLAKVERSSSRKLLAVRSDNGGEFLSNEFSSFLEEQGITRQLSIPDTPQQNGVAERANRSITEGVRSMLHQSGLSHALWAEALATYVYVKNRSPHSANSGVTPHTRWHGSKPSAGHLRVFGCRAWKAATTEARSKLDPRGIPLVFVGYDLESKGYRLFDPATRQVFKSRSVTFFEDEFPARREGITAAHAPVAGDDDDDDDDDDEVVVLPDQHANQAPPDQAELPAALRFDAPGPAWQPPVGSRPRNPPARYGALASLRSTPSAFAFSLGKEVTELVADLEAAGIDTSKANRPLSEPEDPFSLPSSDPTTWNEAMRHPHAAAWKAGAIEEFRSMKDDLKVFSVVELSSVPKGATILPSRHVFRTKRDKAGKMVSLKNRIVAQGCAQGPNSFNNTFSPTAKYTSIRTLIAHSASKGHHIIQADVDKAYLHGVLEEEIYMRVPTGIEGYEGKCLRLHRSIYGLKQAGRVWNDTINATLASLGYRRLACDECIYRHEDAGGDHYIALYVDDLLFFGPDLGEIDRVLDQLDTLYGVKRLGPAEWVLGVQVVRHDDGGISLLQRQYLLDVLARFNMSDCNPCKSPMEANLQLSPEPDTDSADNAIYRSMIGSLMYAVVATRPDLAHSVGYLSRFVGKAGNTHLEAAKRVLRYIKGSLDLGIHYTRTSAPLLGYEGYSDSDWGSDIQTSRSTMGYLFKLAGGAISWSSRLQPRVACSSTEAEYLGLSHAAKEAVFLRSLLTELGLDTSSPLRLLGDNQGAIALTQNPVFHARTKHLRMLEHFVREHVRNGEISVTYIPTHDMVADIFTKPLPRVVFQRHCDAIGLRRISGQEQGGVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LV22</accession>
    <name>A0A2X0LV22_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NADH-ubiquinone oxidoreductase 78 kDa subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BQ5605_C013g07310</name>
        <name evidence="16" type="ORF">BQ5605_C013G07310</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the complex I 75 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LV22"/>
    <dbReference type="STRING" id="796604.A0A2X0LV22"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02773">
        <property type="entry name" value="MopB_Res-Cmplx1_Nad11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.740:FF:000016">
        <property type="entry name" value="NADH dehydrogenase (Quinone), G subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.740:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.210:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000283">
        <property type="entry name" value="NADH_UbQ_OxRdtase_75kDa_su_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054351">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010228">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015405">
        <property type="entry name" value="NDUFS1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050123">
        <property type="entry name" value="Prok_molybdopt-oxidoreductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01973">
        <property type="entry name" value="NuoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105:SF13">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 75 KDA SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105">
        <property type="entry name" value="RESPIRATORY NITRATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13510">
        <property type="entry name" value="Fer2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22151">
        <property type="entry name" value="Fer4_NDSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22117">
        <property type="entry name" value="Fer4_Nqo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09326">
        <property type="entry name" value="NADH_dhqG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53706">
        <property type="entry name" value="Formate dehydrogenase/DMSO reductase, domains 1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00641">
        <property type="entry name" value="COMPLEX1_75K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00642">
        <property type="entry name" value="COMPLEX1_75K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00643">
        <property type="entry name" value="COMPLEX1_75K_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="13">
        <location>
            <begin position="28"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="15">
        <location>
            <begin position="107"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="14">
        <location>
            <begin position="246"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SGY15274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="720" mass="78526" checksum="4CA4F91CDF5E1352" modified="2018-09-12" version="1">MLSRVSRRSLPRFTPPTRSLHSTSAARAEIQLEVDGVPVSIEQGSSLIQACEKAGATVPRFCYHDRLNIAGNCRMCLVEVTPGPPKPQASCAMPAMPGQKVKTSTPTVHKAREGVMEFLLANHPLDCPVCDQGGECDLQDQSMRYGSDRSRFHEITGKRATEDKNFGPLIKTVMTRCIHCTRCVRFANEVAGVQDLGTSGRGNDMQIGTYIEKTINSEMSGNIIDLCPVGALTSKPQAFEYRPWELKHTESIDVLDAVGSNIRVDSRGLLVMRIQPRLNDHINEEWISDKTRFAVDGLKAQRLTTPLVREGDRFVPATWPEAFKAIKAGLAKTGANGNEIQAIAGHLADSESLVALKDLTNALGSDNTTLDSPLGEYSPAHGVDFRSNYSFNSTIAGAEEADRIVLIGTNPRHEAAILNARLRKIYLHNGVDVAVVGQQFDSTFGYDHLGDDLNAVKSLFSADSKWAKQLKSAKKPMIIVGSAVAEHESGAAVLAEVAKFVEANKAKFVTEEWVGYNVLQRAASRTAAYDVGFVPSADASKTTAKFVYLLNADDFSPKQIPRDAFVVYQGHHGDLGAQYADVCLPGSAYTEKSTTWVNTEGRTQLGRAAVPPPGQAREDWKIVRALSEVLGKRLPYDDTSALRDRMWDVSPTLVRYDVVERPSSVLAGLKALQVEAANVGKVKRKGGRTGKFVKPIDNFYRTDPVSRSSVTMGKCTEAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LW13</accession>
    <name>A0A2X0LW13_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methylthioribulose-1-phosphate dehydratase</fullName>
            <shortName evidence="2">MTRu-1-P dehydratase</shortName>
            <ecNumber evidence="2">4.2.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C012g06913</name>
        <name evidence="2" type="synonym">MDE1</name>
        <name evidence="5" type="ORF">BQ5605_C012G06913</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>5-(methylsulfanyl)-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15549"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="ChEBI" id="CHEBI:58828"/>
            <dbReference type="EC" id="4.2.1.109"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldolase class II family. MtnB subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.109" evidence="2"/>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LW13"/>
    <dbReference type="STRING" id="796604.A0A2X0LW13"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046570">
        <property type="term" value="F:methylthioribulose 1-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03116">
        <property type="entry name" value="Salvage_MtnB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027514">
        <property type="entry name" value="Salvage_MtnB_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640:SF7">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="4">
        <location>
            <begin position="38"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY16572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="326" mass="36802" checksum="FEFA87D1AADA1AFB" modified="2018-09-12" version="1">MAPEKSSAHALLAPPTDGKTPNQHELVDHQGDPEHPAYLIPTLCQNFYKLGWVTGTGGGISIRQGEKVYLAPSGVQKERIQPKDIFVLTLSTRSFLRWPVHKPLKQSACTPLFYNAYELRNAGACIHTHSQHAVMATLLWKGNEFRVSHQVSRREEFSHFSELGIWSELLAVTREIFSGFDHVQNSAKQKICFSLTSCDHSHPQEMIKGMRIAGTGSALSYLDTLVIPIIENTPDEEDLREGMEEDRSRADFLRFRQRNSLRILLYCHLSQAMRKYPDAPAVLVRRHGTYSWGADWEKAKAQAECLDYLLEVAVKMKLAGMDTVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LW23</accession>
    <name>A0A2X0LW23_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C013g07319 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C013g07319</name>
        <name evidence="9" type="ORF">BQ5605_C013G07319</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LW23"/>
    <dbReference type="STRING" id="796604.A0A2X0LW23"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019008">
        <property type="entry name" value="Beta_sandwich_EMC7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039163">
        <property type="entry name" value="EMC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605:SF4">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09430">
        <property type="entry name" value="EMC7_beta-sandw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015882232" evidence="7">
        <location>
            <begin position="28"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 7 beta-sandwich" evidence="8">
        <location>
            <begin position="64"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="230"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY15307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="279" mass="30151" checksum="CE2E204100D5AEB4" modified="2018-09-12" version="1">MTRSCLPRSLRRIAFLVVLCLFHAVLASSPLPPASLYGSLLSNLSTPYEHDAFVQLAAPYLPELNSPITRNRSFSFTDLKVAEYVLSVHSRLAQFQFYSVNVTPSHQVDVRLYLPGQGPTRTKPFPQPLLLPALYLKTYTTQPNPFSLLNLLKSNPSLILGGLALILLAILPKLLARLDPETAREVNQSQADLHAKLAGFVSLAGGVGSGGSNGSDELTKNLSRRLAKTKGVVEKMSSEEGEGLEAEGLQDKLSTSLTSAVKQNQGTQTGKGKGGKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LWG6</accession>
    <name>A0A2X0LWG6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C015g07738 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C015g07738</name>
        <name evidence="2" type="ORF">BQ5605_C015G07738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LWG6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY17301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="55" mass="5735" checksum="8091D2BE59B72B6C" modified="2018-09-12" version="1">MLRAAEERSRTANSRGTSGGKLATQLAAQRADGNRAVDARHAGGTRDLPLVVSNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LWM5</accession>
    <name>A0A2X0LWM5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C018g08633 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C018g08633</name>
        <name evidence="1" type="ORF">BQ5605_C018G08633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY25524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LWM5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY25524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="159" mass="18125" checksum="002E617354C16AA2" modified="2018-09-12" version="1">MLCRFPKAAQDAVEKLVREERVFVFLLASAIDGARLTRSSWSDDSVNCRTLFLDKLENLDSGRIQLVVVFFLEFVEEQRSTVDGVVRPRQSAFLPDELLDGTLRRLVESRLIETRLTSWLGLKSRASRALVSLTSSSNFHPRSCTRTQPLESRSSPLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LX79</accession>
    <name>A0A2X0LX79_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C015g07928</name>
        <name evidence="14" type="ORF">BQ5605_C015G07928</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 12">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LX79"/>
    <dbReference type="STRING" id="796604.A0A2X0LX79"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10509">
        <property type="entry name" value="Zn-ribbon_RPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034014">
        <property type="entry name" value="Zn_ribbon_RPC11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF12">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="13">
        <location>
            <begin position="77"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="10">
        <location>
            <begin position="4"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="4"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGY17918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="122" mass="14037" checksum="CD00C6A3B58B0ADB" modified="2018-09-12" version="1">MIFCNYCANLLVVIDSGAGNKWACKTCPYEYPIKKSVSRKVLEGGELKTYREREFLTRKEVDDVLGGEDSWKNVDSTAYDCPKECGANRAFYMQIQIRSADEPSTTFYRCTNAKCAFQWREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LY27</accession>
    <name>A0A2X0LY27_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Casein kinase II subunit beta</fullName>
            <shortName evidence="3">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C014g07614</name>
        <name evidence="5" type="ORF">BQ5605_C014G07614</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2 3">Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY19313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LY27"/>
    <dbReference type="STRING" id="796604.A0A2X0LY27"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="191"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="256"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00045899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY19313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="392" mass="42700" checksum="C2D2F5FD6D95612E" modified="2018-09-12" version="1">MSISTDALPPDSSTVDVDSHLSPTSVDHHGMQPDLPHDDEEEEDEDDELEEDQVEVEVEVEGYESSSSPSTNTSTLTWITWFCSLPGHEYFCEIAEDFIEDDFNLTGLSGLVPFYKEAMEMVLDVEAGEYTPPLDSSHRVPDVSIVESSAELLYGLIHQRYILTRQGLQQMASAFFGTTFPHLLFQTYPSPLNFPPPAPAPNPTDSDPNPTRRELTTPTTSLAKVYVPKIYGFKVSERARSGPRMQWLRMRPKTEGELDWSDDQDDLGLHDDQDDGDEIRRAHGRGGGGGRGKLFGDDDEDEEGGPTNQSEDASDQDVVVEAGEGEGGTTPGEPMQMSGVVVAEKQASLSESVRRHVARAKEEMVRFASGGGAGSANGKVMAVRSTSVGVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LY60</accession>
    <name>A0A2X0LY60_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BQ5605_C014g07432 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">BQ5605_C054g12629 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C014g07432</name>
        <name evidence="12" type="synonym">BQ5605_C054g12629</name>
        <name evidence="11" type="ORF">BQ5605_C014G07432</name>
        <name evidence="12" type="ORF">BQ5605_C054G12629</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY18664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000093">
        <property type="protein sequence ID" value="SGZ29356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LY60"/>
    <dbReference type="STRING" id="796604.A0A2X0LY60"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="9">
        <location>
            <begin position="18"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase RNase H-like" evidence="10">
        <location>
            <begin position="232"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY18664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGZ29356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="319" mass="36254" checksum="397377B1F774FF1B" modified="2018-09-12" version="1">MFSPIPDMQTVRADVARSPFRSKVDVAAAFEQVRVVPRDVSKTRFATVTGTYTSHVMQFGDTNAPNTLNLVTNMMFHPCAEFLKIFFDVIHLHSPTRCAHLRHIRILLTTLRHYRFYLGRGRTEWFSLQLDSLGAVITDNGIAVNPSKWERIKNWPRPRNILDVQRFMGTINWMRDHLPQLSTILAPITRLTSKSVTWVWTNREEAAFAQVKALVPQVLRPIDSAKVLLGEHRIFLATDACTVGIGACLLSGPTYDTAVPFCFHSAKFNPAQSRYNTTNQELLAVVTACKEFEQHLLGYPFMVLSDNAGIQMFHTLFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LYY3</accession>
    <name>A0A2X0LYY3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BQ5605_C002g01516 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C002g01516</name>
        <name evidence="12" type="ORF">BQ5605_C002G01516</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the anamorsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY33618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LYY3"/>
    <dbReference type="STRING" id="796604.A0A2X0LYY3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03115">
        <property type="entry name" value="Anamorsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007785">
        <property type="entry name" value="Anamorsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046408">
        <property type="entry name" value="CIAPIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273:SF14">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05093">
        <property type="entry name" value="CIAPIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anamorsin C-terminal" evidence="11">
        <location>
            <begin position="228"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Fe-S binding site B" evidence="9">
        <location>
            <begin position="290"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 1" evidence="9">
        <location>
            <begin position="290"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 2" evidence="9">
        <location>
            <begin position="301"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY33618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="329" mass="33471" checksum="27816D882EBD0931" modified="2018-09-12" version="1">MAPIGFDMSDDLDDLTGSNPATSNGAAAASPASILVLSCQQAAGDGSYQSLVQSLIRLGQGQVEMHMFDPTVLTPAQYQHISILLPATLITPSLLGLIEPSLAPGGVLQVHGQEAASSESVVNDLKAVPVFAGNVATDQKDPTVLLCSKPIAPLSDPSSTSAPAAKSSDAPSSTSAPASVALPLRSSRAAKAAKASLWAFTSSNGAATPTIDESTLLTPEDLERPSLVEREDCNVKKTRKACKNCSCGLRELLLQEKDDLGAAGFAEGTTGVNGAAPGVGTMGANVTSSCGSCYLGDAFRCASCPYLGMPAFEPGQKVAIGGHDDKPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZ35</accession>
    <name>A0A2X0LZ35_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C017g08364 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C017g08364</name>
        <name evidence="25" type="ORF">BQ5605_C017G08364</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY19878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="415"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="159"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGY19878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1333" mass="149023" checksum="59EB637CC77A07AA" modified="2018-09-12" version="1">MVKSKSLSAKNIWEKLKQHHEGNADPFKIRTLLYEISNASYDEDTNLGEFLQGITDKVDQLEDLGQKFKDEAIVAFMLQALPPSYEMLKQAIKLSDKCSVDYAINRLTDEYSERKLTGKYDKLLKNAGALAVREGTQVKRDPNCICRGCKGTGHYQIDPECPKYDPNAKRGRNKNHSNKKKKQHKHSKGSADSEESASFALVVKSLEESHSLHINVANRVSQNDQSEIWILDTGASQHYVGNASLLTDRQHGSLNVQTASGQVVHCDTYGTVRFKLRSGASLSLSNVYHLPGAPVNLVSTRALYRSGASCGWEDGRDVMTIKIKGLTVAKTLNGTGYTLDFTRIVEDQAHVATRATVGAPLMEWHRRYGHIAVSSLKELVKSGAVDGLVLTDEKVHDCEPCISSKSRVLKFSESVTHVTDVLQRIFMDIGFVAEDQVDFQGRKAYLAIVDQYSTAKWTFPLKTKLAKEVTCVWITFRQGVEKMTGRKIKRVRTDNGNEFTNKLIGTDFQSQGILHETSAPYTPQQNGTVEHFNGSLMAIICAVLAASKLSWKYWSYAMEYATFVANRVLHSKLDGKTAYEVFYGKKPKVSHFRPFGSTVFAQVPKSKRSKLEPTSVRGTFIGYDNEYNYHVLVNSDSEHKVVITCDIAVLNLQPEEVRAPEVTTLLEGPDEDVGPVLEGNDAGDKLQDEVAVEQIAPARPNRPRWEYGDPAVRGRNPGRFEEIDAGNEIHQRTCGQRRIAEQQGLFVTDIPELDPEPPIMSGYAMISTDRPAVPSSYEEAVNNVKVDKWKEAIQDELNAMDCHQVLADSDLPHGARALGLKWVFARKENAQGEVIRYKARLVAQGFAQRSGIDYNETFAPVARSTMILFLIAIAASQGLCLEQFDYDSAFLNGMMTEMVYMKYPKGWDHPQLGQVLRLVKSMYGTKQAPREWNSAVNKLMVACGYSRSDANSCLYVKRVKEMFIYITLYIDDGLAASNDQTFLDLEIQAFNKVYQLKRLGPVKVFLGLEFLRSSKFIFVHQSKYIRSLVATYGGDHGSKHPAKVPMEPRLNMEHSAELFDDNALYQSAVGALQYAAHCARPDIVTSVCAAASKVSAPTQADWIAVKRIIRYLQGTIDWGLKYNLEGSTVFELYSDASWGDDMLTGKSIGAFVSIMAGAAISWQSKQQSMVATSTTEAEILAASATAKEAMWLRHLAADLKIQQPGSTLLWEDNQAVIAIAQSPAHHGRTKHYSYCKTGAMTADLLTKPLARNLFELHRDGLGMGQRSRGTCGIGKLARAWRGAGWRQMAVWRIDWTQRFEATCERHKIALEPHWFRVQTERIKRCNSQAKKDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZX7</accession>
    <name>A0A2X0LZX7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial</fullName>
            <ecNumber evidence="4">2.1.1.201</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ubiquinone biosynthesis methyltransferase COQ5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C016g08102</name>
        <name evidence="4" type="synonym">COQ5</name>
        <name evidence="6" type="ORF">BQ5605_C016G08102</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-methionine = a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="EC" id="2.1.1.201"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.201" evidence="4"/>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY20593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LZX7"/>
    <dbReference type="STRING" id="796604.A0A2X0LZX7"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008425">
        <property type="term" value="F:2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000208">
        <property type="entry name" value="2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01813">
        <property type="entry name" value="MenG_UbiE_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01183">
        <property type="entry name" value="UBIE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01184">
        <property type="entry name" value="UBIE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="18"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="219"/>
            <end position="220"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY20593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="351" mass="38574" checksum="E54946E69691C2BD" modified="2018-09-12" version="1">MSLLRSNHQLGRSFARCLSSSSRCATHPTKPLDPAIDAAHSPISSHPHPAPVAPSPSPSSPAPATPYTSPFDSHAPPTASTSQAGQYPHSQAPPSPSTHFGFKDVPEQLKESLVKGVFSSVASSYDVMNDAMSLGIHRLWKDHYVSKMDPRDGMRCLDVAGGTGDIAMRLLDHARTKYADRDVHVQILDINPEMLDEGRKRFAKSMYHGGPQVSFTLGNAEELSTIPDNSIDLYTIAFGIRNCTHIDRVLEQAHRVLKPGGVFSCLEFSKVSNPLLAKAYQLYSFQVIPTLGHVIASDRDSYQYLVESIERFPPQARFSKMIEEAGFTIPRREPWEDLTFGIAAIHTGVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M006</accession>
    <name>A0A2X0M006_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">triacylglycerol lipase</fullName>
            <ecNumber evidence="2">3.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C019g08895</name>
        <name evidence="7" type="ORF">BQ5605_C019G08895</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="2"/>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY23096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M006"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF1">
        <property type="entry name" value="LIPASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015802473" description="triacylglycerol lipase" evidence="6">
        <location>
            <begin position="26"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR029171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY23096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="426" mass="45250" checksum="2F43AECDEA17D678" modified="2018-09-12" version="1">MLSPRSSWFARVTSSILALTVLVSAAPILDLTSPATFLIPTPDVDPFYRPPSTFAKDAPGTVYRSRAALNPGFGRKGTQILFRTSDAFGKPTTSVTTILQTLNSSKNYLVAYNMYEDASAPQCAPSYCFNTIPQKSFCPDGDGQLVYFMTKGWIVIVTDFGGKTSSFSVGHQSGYQILDGYRAAIKFLKLSENVVLGGYGYSGGAIGTGWSAALQNNYAPELNIKALAFGGTPSNMTSTFYQLNAGAFAGFAVGGLAGQVASYPELNARFSQIATAKGKAAIITGHSQCGAADIVKFAFTDILSTDFQSLGSQFLSDPIVAKYLTMSTMGSVASETPTKPSILMFHSTMDEVIPYTSALKTAQTWCSDGAKITFITELGGGGHLGTQISYGPMTIDWLDNSLRSKSPATSTCSFKTQSTAALPVRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M0A6</accession>
    <name>A0A2X0M0A6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C019g09005 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C019g09005</name>
        <name evidence="1" type="ORF">BQ5605_C019G09005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY24040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M0A6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY24040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="90" mass="9408" checksum="748A340166A2D1EF" modified="2018-09-12" version="1">MAAQVIIAHARFIFNAVDQTLVRSHPLATSSNDACPALAGSTGQWQVHKCAMSAPKAQPKPGRPSSLAYTLGPLSDGLTPLSGPWQLADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M0N9</accession>
    <name>A0A2X0M0N9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C018g08679 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C018g08679</name>
        <name evidence="1" type="ORF">BQ5605_C018G08679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY25902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M0N9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY25902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="94" mass="9787" checksum="E929711F744B5C66" modified="2018-09-12" version="1">MFSLASAAAVSRSSTIVSTACNTVEPFRTGRLGTARAQAFPAILGHQLPPGSGGRRALAPSTWSSGARAGSAEQLSGFFRTQCSVVTSQYWHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M2E0</accession>
    <name>A0A2X0M2E0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM2-LSM8 complex subunit LSM8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C001g00130</name>
        <name evidence="9" type="synonym">LSM8</name>
        <name evidence="11" type="ORF">BQ5605_C001G00130</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY44212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M2E0"/>
    <dbReference type="STRING" id="796604.A0A2X0M2E0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01727">
        <property type="entry name" value="LSm8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000027">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034103">
        <property type="entry name" value="Lsm8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF9">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="56"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY44212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="152" mass="16462" checksum="5B72726139BFBC1C" modified="2018-09-12" version="1">MTRVTARSSILDLVSPHPLTPLAPSLGIPGSPLIRRASLGHFATVSQLRKRTRRSDAVSALTAYVDKRVLVITQDGRTIVGTFAGFDQTTNIILSSSTERIYSLDEGVDEQPLGLFVVRGDNITLIGELDEVADKAVDLSTVRAEPIQEIVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M6J6</accession>
    <name>A0A2X0M6J6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C006g04296 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C006g04296</name>
        <name evidence="10" type="ORF">BQ5605_C006G04296</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY57663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M6J6"/>
    <dbReference type="STRING" id="796604.A0A2X0M6J6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000001">
        <property type="entry name" value="Cysteine and glycine-rich protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215:SF35">
        <property type="entry name" value="MUSCLE LIM PROTEIN MLP84B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="9">
        <location>
            <begin position="9"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="9">
        <location>
            <begin position="203"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="117"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY57663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="287" mass="30270" checksum="348564FC36CA0464" modified="2018-09-12" version="1">MPPTFAAAPKCTYCGKSVYFAEARWKGDSRCPLFHQIAAIRQVASNRHLARVNSCPSTIYHKPCLKCSSCGKTLEPGALLDHAGDPYCKACYGKAFGTRGYGVGGALVADYHDPRAVSKNPSGHSQDVAAASLSASTPNSPFSASQAAPAPDMPCTGPSRMAETDSYRPRASLPNMPRPTVPPKPFLAGRASVSTPPGRISSDLCPRCQTTVYAAEHVLAAGSKRCLRCAGCSTALASGQLNEKDGEPWCRHCYANKFGHLAHGVTDVGKSARIVCRSKTPALTKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-10-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MAF2</accession>
    <name>A0A2X0MAF2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C007g04586 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C007g04586</name>
        <name evidence="6" type="ORF">BQ5605_C007G04586</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY61674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MAF2"/>
    <dbReference type="STRING" id="796604.A0A2X0MAF2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008726">
        <property type="term" value="F:alkanesulfonate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046306">
        <property type="term" value="P:alkanesulfonate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01094">
        <property type="entry name" value="Alkanesulfonate_monoxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024014">
        <property type="entry name" value="DMSO2_SphG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050172">
        <property type="entry name" value="SsuD_RutA_monooxygenase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04021">
        <property type="entry name" value="LLM_DMSO2_sfnG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42847">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42847:SF4">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="5">
        <location>
            <begin position="89"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY61674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="425" mass="46983" checksum="EEBC78285E6F31D4" modified="2018-09-12" version="1">MPSTEAFASARGDSDEAARAPLQFGYWVPNVSGGLVVSKIEQRTDWSPEYNVSDNIGHTSHVTFRSFGPTGFRCLSPSFLSSSIWPQPYQVKLAQIAESVGFSHALTQIRFMGGYGAEFQHESASFSQHLLAHTTKLKLIIAILPGPWNPTLAAKQLASIDHYSNGRVAVNIVSGWFKGEFQAINEPWLDHGERYRRSEEFIKVLRGIWTAPESFNNNYPLRPQPIQKNGPEIFQGGNSADARGMAARVSDLLLLNGQKTIADIRELIDDTKERAVKEGRAGQVRLGINAFVIVRETEEEALAVWREIVGKADTEAVQGFLQQAMNAGASASDKKGMWANSDVNDLVQYNDGFKSKLIGTARQVADRILLFRSLGIDFVLTAFLHFQEEIEAFGRGVMPLVRQGESEGRGLDAEKEIAISGHIYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MBT4</accession>
    <name>A0A2X0MBT4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">BQ5605_C008g05026 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C008g05026</name>
        <name evidence="13" type="ORF">BQ5605_C008G05026</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM U1 A/B'' family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MBT4"/>
    <dbReference type="STRING" id="796604.A0A2X0MBT4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030532">
        <property type="term" value="C:small nuclear ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12247">
        <property type="entry name" value="RRM2_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000039">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000029">
        <property type="entry name" value="U2 small nuclear ribonucleoprotein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="72"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="252"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="158"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="9"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="158"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGY79061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="335" mass="36245" checksum="26FB6D898C9754A9" modified="2018-09-12" version="1">MQSPAVEIASVASTEPSTSASASTSTAPTAPNPAAGDVEMTAATDPTTATADALNGEQAQQPEREEEEPRFEVVYINNLNEKVKLAVMKQSLTTLFKEYGKVLGVTLHRNVRMRGQAFVTLHDSKAAQLAVKEVKGFPLYGKPMQLAFAKTRSDALVKKKDPQHMSEHIAERTVRKKLSRRENPLRKKELQKKLAAKQAAEAAAAASSSLPDAGASTTTSTTANGAPTSTTTTTAAPRRQVQMPDEYLPPNKILFIQNLPSKTTKAHLEAVFAPYPGLVEVRTIPGRSNIAFVEFVDEVQSAPAKEALHNTKPWEEVMPGDEEAGLRIKVTFAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MCM2</accession>
    <name>A0A2X0MCM2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C013g07254 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C013g07254</name>
        <name evidence="2" type="ORF">BQ5605_C013G07254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MCM2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY15124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="205" mass="23278" checksum="3CE2FB8154CD016F" modified="2018-09-12" version="1">MSSIGAWPEIISTSAGTWGSPLTQVCTPQIQYFIEWEKEDKDNRSKFFIGLQNYLVKVGKRLGAKLDKEPNFSIRTYVPIFIDYLSRTPFHSAFWLSATKYPTRTSINILTSYVEPTRRSAAASKFGTANSMDWKQPLARLQTTKDDAQSQMFLLVVKTNLDIHQVARKLATKRSRSTAYTAGQRGNAHDSRSWSRGEPGLFSNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MD80</accession>
    <name>A0A2X0MD80_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Saccharopine dehydrogenase [NAD(+), L-lysine-forming]</fullName>
            <shortName evidence="13">SDH</shortName>
            <ecNumber evidence="4 13">1.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 13">Lysine--2-oxoglutarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">BQ5605_C008g05373</name>
        <name evidence="19" type="ORF">BQ5605_C008G05373</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>L-saccharopine + NAD(+) + H2O = L-lysine + 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12440"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57951"/>
            <dbReference type="EC" id="1.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.7" evidence="4 13"/>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY80385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MD80"/>
    <dbReference type="STRING" id="796604.A0A2X0MD80"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00034"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004754">
        <property type="term" value="F:saccharopine dehydrogenase (NAD+, L-lysine-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd12188">
        <property type="entry name" value="SDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000217">
        <property type="entry name" value="Saccharopine dehydrogenase [NAD(+), L-lysine-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027281">
        <property type="entry name" value="Lys1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF23">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE [NAD(+), L-LYSINE-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018250">
        <property type="entry name" value="Saccharopine_DH_Lys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 13" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="8 13 15" id="KW-0520">NAD</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="18">
        <location>
            <begin position="9"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="17">
        <location>
            <begin position="176"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="204"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="322"/>
            <end position="325"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="206"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR018250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="SGY80385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="397" mass="44349" checksum="4447F379645471A1" modified="2018-09-12" version="1">MSTPTAKLWLRCETKEFEHRACLTPTTAKQLMDAGFQITVEEDPQRVFEDSEYEKVGCKMVKHNTWPSASQDEIIIGLKELPPNDSSALPHMHIMFAHCYKTQAGWIDVLNRWDKAQPTGMLYDLEFLQDERGRRVAAFGYHAGFAGAAVGALALAEQVKDKRLGKIEPYPNEKQLIEHVKTQLEQVKKSLGRPVKALVIGALGRCGRGAVDFFLAAGLNSEDVIKWDMAETAKGGPFDEILEVDIFVNCIYLSHKIPSFVSRDSIAAYKRDRQLRCVVDVSCDTTNPNNPIPIYDINTTFDKPTVDVEGITSGPTLTVVSIDHLPTLLPREASEAFSKDLLPSLLKLPQAIEERKKRGLGRSIKITEVGTGPERVWKEAEALFWDKLEESRVAAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MDG2</accession>
    <name>A0A2X0MDG2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C004g02967 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C004g02967</name>
        <name evidence="1" type="ORF">BQ5605_C004G02967</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY69145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MDG2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY69145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="129" mass="15107" checksum="7532A96E34715468" modified="2018-09-12" version="1">MRQIKVLDLFTPNAVGLPVAAILGPSPFECAIRSTIEFLRIEMTGYRFNTFVLWAQDNPPPNKLRYLSLRIQESVQDDARDNLLRVWTKVKITVVVVRENRRREEGYDELFWNRVERGYFDPILADPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MDY3</accession>
    <name>A0A2X0MDY3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C009g05797 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C009g05797</name>
        <name evidence="8" type="ORF">BQ5605_C009G05797</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY86058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MDY3"/>
    <dbReference type="STRING" id="796604.A0A2X0MDY3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="64"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY86058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="782" mass="84688" checksum="60E4ED87BC37D3CC" modified="2018-09-12" version="1">MDQTPVASTSASASTSPAPFATGSAALEATHQPPQAVQSEAPTPSFSGAQKKASTGTKRRKLPSCDSCRLRRVLCVPVPPPGSCSRCLEKGIICTSTPVIRKKPVGRTGRRIEEARAMFGATEAGSSNSAPAENQPWLGSSTFTLAENFTPIPSVMGASSSLPTVSANDLDSRLGLTQLSGELVAHLLGLYQALPQSWLPLLPRARITTMFEASGRRLSSLPPQAEVLAYTIMALTSRLSSHPYILGDGPPAPAFESLTSQSLKERPDLQAFGARRDAVCEKMRAKAVQLAWERGTLVEASEETMASCHLLDILESRTNTKKGVPYVSAFVTHLRTLLDERDTTGGMGKIIHQPLGWAALIMREALAALRTGGRSHFMDDEILVGPVPPSIEEALLQTVDDIDVRDSVSLFFRPMRPYMYHVTRLARECTDRVTCKCNELILPNLSPDVAWVRNRPLDEAFVSKYLAQLDSLERLLLLLSERIAFSLSPAATSAHALPAPFETERRYIMTSCIHTLRLAWASLILPLCTNLKRRLSMMEVGTISPEQRRTRDRLLLLRRHAQQGLVKGARMIAACLDSPPSLGYLTHVQQERIDNWADVLLDSTRDDDVISQEEQFSDLQTILAGLKMIGWSWPDNAQLIGSLEERLNSMEIGDSGRARAAAITSISTLQASGVGNAAQAGGDDLCSFPQYLATPSPPQASTGLSSATSATPTCSFSASPASMEYGPIANVARSPPDQRMVQPLLPLTAGVGSDPSWGSFGDEFNQMLDDGTGMNPFLPRWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MFL6</accession>
    <name>A0A2X0MFL6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C008g05122 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C008g05122</name>
        <name evidence="4" type="ORF">BQ5605_C008G05122</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MFL6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016115504" evidence="3">
        <location>
            <begin position="24"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY79401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="449" mass="45039" checksum="6C6CA9D0825FE714" modified="2018-09-12" version="1">MRVTDQAALWCVVAAPLWLAATASLTSGDAEAAAVVAPAAVAANERQPLIDTRSHDDDVERVGVGRRNIHPGTRSTSHRQKKLVKQHKLLVTRQIITDNSTGVGGLLGGLLGGSSSGSGSESDSGSASGSDSGSASGSGSGSGSAAGSGSAEGSNTTSNPLDNTTAIAPPVSITTNVSTPTQTPNVTTAPPAVSNTTKAPAAPAATTTTTTHTKASSAPSSVPTSSSAPPTSTVTNASQTSTSSSPTPTATTANDTANKASSSGLSKTALIIIIAVASSVGFIGLVWTIIRKTAFGTSKRFDAKLEPIEWTEPVEQHHRDETYPYGSLGGSGRNGSLRGTTVGASAASLDRSDSGKGSDRGGAMAEAYPQSIPYNGPAYVAAPYYGNAPANQYGARPGYPHEQASFGYADLQRGGSVATSVGSGAARAATPGGYDYAAQARAMHQPSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MG50</accession>
    <name>A0A2X0MG50_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C008g05050 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C008g05050</name>
        <name evidence="5" type="ORF">BQ5605_C008G05050</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MG50"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010488">
        <property type="entry name" value="Zeta_toxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06414">
        <property type="entry name" value="Zeta_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zeta toxin" evidence="4">
        <location>
            <begin position="102"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY79125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="341" mass="38304" checksum="EC94602D8207C2F6" modified="2018-09-12" version="1">MSNESIVSPTSTNEPPPELTPAQLTRSTAELYARPTPSSSLSDSDTHHGLYAAQRKELDWKYHRIPTKERQLLQDSILSSVLARAHRDCERRRSDGPEESDHSNKPLALFTAGGMGAGKGHTLREMLKDGTIRLPRDFVWVDPDALARELPEREQYLRADAKTASNKLHSEAALLQEILSEVARSKRRSLVVDGSLSDCAWFSKLMKRYGADGYDCEIVFVTAPEEKMLERAQRRAKITGRITNPDALKHSREKSPQCVTQLSTPAHVRRCAKCDLPRRVRLVDNASDDAPSRIVYDSDKDPIWRDRPDDAGVDVKGFVDGRLEQGEDGVVREKADRKAHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MGC3</accession>
    <name>A0A2X0MGC3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C017g08399 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C017g08399</name>
        <name evidence="5" type="ORF">BQ5605_C017G08399</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY19946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MGC3"/>
    <dbReference type="STRING" id="796604.A0A2X0MGC3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00029">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="4">
        <location>
            <begin position="304"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="367"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="367"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY19946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="403" mass="43734" checksum="167C919757110257" modified="2018-09-12" version="1">MTYCEIVKVPKTRTGSQVSDTQEQSGVVGSSIIRDNIAKGVEAQEVQDEEDTSDGLDDINLLDLADMGSDGPHHRGGAGLKLGSDHLYTGSEFDQEWKSHERSSFLCQGQRQAEWSTLTVKAPPMKTTAQNKGRVRLSTMAALSSGLLASLPTSWLEQQRKQVGLGPLIKNWVQEGQGEGMSERLDGPGSEIVSENMIPAEPQVRVEPQEQAETSGGEVFHSTIQGHAQDFVSARSSDLLPTSSSSLILIAQPHRFTLVKPGFQKVLAALLTYGQAPPPTIEPSKPTKLLAFASGSKPKQSLRPQTTNLRSSPMVGEDKCAYCEKNFGTFGWRAYLECDDCTIKCHIKCSDEMDLDCHQHQSLTPAQTVTSSALSRNPRTLLSPLNGGGPKGKLSSARTKWTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MGF8</accession>
    <name>A0A2X0MGF8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">BQ5605_C008g05160 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">BQ5605_C008g05160</name>
        <name evidence="17" type="ORF">BQ5605_C008G05160</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MGF8"/>
    <dbReference type="STRING" id="796604.A0A2X0MGF8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF2">
        <property type="entry name" value="GPI ANCHORED CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G10580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016040277" evidence="15">
        <location>
            <begin position="22"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="16">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="100"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="SGY79549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="165" mass="17049" checksum="1B8C81ABC142B5E9" modified="2018-09-12" version="1">MLFQLPLALSAFVLAATVALADDPTLPACGLKCATDIPPKSPCLYVTNVSCACTNEVYSRLFRDCISQACNNSKDLQAVADFGRETCKALNITPDTGGLDGKIDAIRSGSPKNSSQPSTDSHQQNVNPSLSSPSSSAASSPPASSLHAPILIRFGLVSIGLAALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MGQ4</accession>
    <name>A0A2X0MGQ4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Peroxidase</fullName>
            <ecNumber evidence="13">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">BQ5605_C034g11344</name>
        <name evidence="15" type="ORF">BQ5605_C034G11344</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 Fe(II)-[cytochrome c] + H2O2 + 2 H(+) = 2 Fe(III)-[cytochrome c] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:16581"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.11.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="13"/>
    <dbReference type="EMBL" id="FQNC01000065">
        <property type="protein sequence ID" value="SGZ00380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MGQ4"/>
    <dbReference type="STRING" id="796604.A0A2X0MGQ4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004130">
        <property type="term" value="F:cytochrome-c peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00691">
        <property type="entry name" value="ascorbate_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000009">
        <property type="entry name" value="Ascorbate peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000005">
        <property type="entry name" value="Cytochrome c peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002207">
        <property type="entry name" value="Peroxidase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF58">
        <property type="entry name" value="CYTOCHROME C PEROXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00459">
        <property type="entry name" value="ASPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 13" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="14">
        <location>
            <begin position="148"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SGZ00380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="355" mass="38983" checksum="001ED83C17896201" modified="2018-09-12" version="1">MSFATRSLLRSSRFVAPRLAVRQPVLARRTYATGAPASGGSNTTLFALLGAAALGGGAYYAFSGHSDSDPTKIKDAASPQTVDYQKVYDAIAQVLEAEDYDDGSYGPVLVRLAWHASGTYDKTTGNGGSNGATMRFAPEANHGANAGLDVARNLLEPIKKQFPEITYSDLWTLAGVCAIQEMGGPTIPWRAGRKDGNVENCTPDGRLPDGDKGADHLRHIFYRMGFNDQEIVALSGAHAVGRCHTDRSGFSGPWQHSPTSFNNEYYKLLLNEKWQFKKWKGPIQYEDKSTKSLMMLTTDMALTTDKAFRPYTEQYAKDENKFFADFSNVFVKLIELGVPEKQLSEPLKLRPTGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MGW7</accession>
    <name>A0A2X0MGW7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C008g05131 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C008g05131</name>
        <name evidence="3" type="ORF">BQ5605_C008G05131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MGW7"/>
    <dbReference type="STRING" id="796604.A0A2X0MGW7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38120">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38120:SF1">
        <property type="entry name" value="M PROTEIN, SEROTYPE 2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="266"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="404"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="625"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="718"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="809"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="860"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="355"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="287"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="426"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="459"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="509"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="628"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="723"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="750"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="828"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY79437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="918" mass="98785" checksum="09E1433F8C47F426" modified="2018-09-12" version="1">MDRSGAPSRLPLAPLIIPAGEAEQGRAASEGVTAQPPITATPTAQDPVAQAQGSDLEQLAAARPPLAAEVRAHRRLRSRRQESLQFAGRTSAIDWSKIIMASNGVEDGGVGGGNLTDENDFDQLSRDEILQVFQRQYLEMEDLRSRVNSLEDDQATLVNENGDVLKQLDNARATNSDLLAEQARMEEELAGRIEVLDKLRASVRELEREKRDASKRYREQLRRSNTSAPVLRAQADSFDSERQAWYDQEAHYKGRIANLANVGARRTPRSSLGFEASLAPSPKKSDEDEQSTLSPEDDLPASKEGKTSDGESSNSSVPSRKKVSAPSTGPTANELALQEQLTTLSTAHESLTVTLRTVQHELTDLKRVYQDLQEENESYEILLGEKTLNGEVRDTDLFKRSFQWEETEGSTPLSEGLGFMGGLESVGEEEDFSDDDEEDSEERELDDDEVELALLEAQGTGSPNSGAVQTKGGSRRRAKKRPSVESGAGGGLDLAAELEMAQAVDHEEEERKAAKLERRRASEARKATAGAQKRKDSMPSMPQSVEELQKELKALHEANRALTLYVTKIVERVCSQEGFEKVLAVDYRNATPKAATPAFVAAEEAPASKSQQPTDDQEVIKFRPSAVSRTSASLRSPAASSTLSPTSAQKKGWGDTLSAVLPFTLTRTPQVASAVPTGMKPLRLTSDGSARKVAISDEIEDEDDIRERELLRQEMARIGISPTAASDPTSALPTASTGGNNWIGKKSSSSDRSSSTRHSVGSASSSNPCDSSLSGSTRTTQTSPPTPQEIDAEVQEVLQLRVVKEKQAKEALEQGKASGFTEPRRLSRPSSLMRHPSRSSVSYITGSATPIGVGLGIDAGLAAPNKSPGLAGATSPKPGDTSAVNSPVTAAEVDSAAPWGSKALRRLSMGWTAPAPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MH12</accession>
    <name>A0A2X0MH12_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="10">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BQ5605_C009g05623</name>
        <name evidence="16" type="ORF">BQ5605_C009G05623</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10 13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10 13">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="10"/>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY83191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MH12"/>
    <dbReference type="STRING" id="796604.A0A2X0MH12"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006739">
        <property type="term" value="P:NADP+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000016">
        <property type="entry name" value="Isocitrate dehydrogenase [NADP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004790">
        <property type="entry name" value="Isocitrate_DH_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00127">
        <property type="entry name" value="nadp_idh_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006156">
        <property type="entry name" value="PRK08299.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822:SF21">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822">
        <property type="entry name" value="NADP-SPECIFIC ISOCITRATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000108">
        <property type="entry name" value="IDH_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 10 13" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10 14" id="KW-0521">NADP</keyword>
    <keyword evidence="7 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="14"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="83"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="102"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="318"/>
            <end position="323"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="11">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="11">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SGY83191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="426" mass="48026" checksum="84AD29D6AE92F711" modified="2018-09-12" version="1">MPTEFNKIKVENPIVEVSGRMDGDEMTRIIWHKIRAELILPFLDVDIKYYDLGLEYRDETDDKVTVDAAEAILKYGVGVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIIVEKVPKSVPGWVKPIIVGRHAHGDQYRATDIIIPEPGKLELVYTPDDASKKPTNLEVFHFKTPGMGLAMYNTQQSVRDFAHASFKMAIEKKLPLYMSTKNTILKGYDGQWKDIFQAIYESDYAPEFKKLGIWYEHRLIDDMVAQMIKSSGGFIMALKNYDGDVQSDIIAQGFGSLGLMSSELLTPDGKVIESEAAHGTVTRHYREHQKGNETSTNSIASIFAWTRGLIFMGKRDNNDALVKFGKDLEACCVEAVDVDGVMTKDLALSIHGKNMKREHYVNTSDFLDHIRDSLTKKFKASQSKASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MH39</accession>
    <name>A0A2X0MH39_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C008g05201 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C008g05201</name>
        <name evidence="3" type="ORF">BQ5605_C008G05201</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MH39"/>
    <dbReference type="STRING" id="796604.A0A2X0MH39"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13971">
        <property type="entry name" value="ADCK2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044095">
        <property type="entry name" value="ADCK2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052402">
        <property type="entry name" value="ADCK_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45890:SF1">
        <property type="entry name" value="AARF DOMAIN CONTAINING KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45890">
        <property type="entry name" value="AARF DOMAIN CONTAINING KINASE 2 (PREDICTED)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="2">
        <location>
            <begin position="323"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="2">
        <location>
            <begin position="415"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY79693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="811" mass="91397" checksum="EC03284182BD8069" modified="2018-09-12" version="1">MRAGFLSWIPIGFFFVRRAIVTFIHLPLLSARNRSQLVGHQHGSDVKTMLSRQLSSISRLARPGRSSSGVLQRPLSSLSLPLHASRSNRPRLPVAVVSRASSQSLLSSPTPLPRPTWYGKTFSTIRATGSKNHDHGRGHQWKQTESSSSSWRWSLIPILLAGSSPLLLESHHSHDHVSTSKPSLKSIKENIDHPEESEFLVADGDSPSTSKRPLTLLGRIGRFFVLYVFEPISTTGRFIHLAILFLPVILSAPVLMLEVLDSGRDKRRVFKKKEGPRVTTSWWYWFLVHQMEMAGPTFIKLAQWAGSRTDLFPSELCELFGKLHSNGKPHSLRYTKRVIEQAFGRPFSEIFLEFGEKPMGIGAIAQVYKATINPDLLPDDYLDPKHEKDPSMTSVVTRTITPRPDDLRPPKIPSSAVAIKVLHPGVEKMIARDLKIMMFFARVLNVLPGMEWLSFPEEVQVFGQMMMSQIDLRIEANNLQTFENNFRHRPTVSFPRALKKYTSKRVLFEEFEDAVPLEAFLNKTGGAFDHRLANLGLDAFLHMLLIDDFSHADLHPGNIMVKFFKPTTKSMLSNWFPSLFGEPSHDSAGTADDIEIVHNIREFSKKPAPEFHAELARLDAEGYQPELVFIDAGLVTRLDGQNRQNFLDLFSAVARFDGYEAGRLMVERCRAPELVIDEEQFALRMQHLVLSVKSQTFSLANIKIADVLSEVLNNVRRHHVKMEADFVNTVISILLLEGIGRQLDPGMDLFKSALPILRQLGTTMSTEQMRQGAGGLGLGGLGTMLKVWVWIEARQMAELAVKDVDQLIRYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHI6</accession>
    <name>A0A2X0MHI6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C016g08277 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C016g08277</name>
        <name evidence="2" type="ORF">BQ5605_C016G08277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY21818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHI6"/>
    <dbReference type="STRING" id="796604.A0A2X0MHI6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004861">
        <property type="entry name" value="Siw14-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF14">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE OCA6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03162">
        <property type="entry name" value="Y_phosphatase2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY21818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="478" mass="50113" checksum="947C5EF1653704EC" modified="2018-09-12" version="1">MPHLPALSRSLSVRGCSSITEPTTAKLEDRSLIPPFRFAHLASAALPQHVTSLEPPSSSSSSSPSSPSSPSSSTNSSSFPLYRGSLPRWHNLPFLDTLHLRTIISLTPKPISTYEENGELVGPSGAATRPTEPGPDEARPSSLTTWARQRGVKLVHVKVGKAKDGAIPFTAATVKLVLELLINRTGYPIYIHDMDGSDVVAMMGAALRKLQGWSEGAWSEEMSRYLRQPPPEPEHLAFLRRLLPPTTHTSNNTASSTVPPSSSCNPTPTKPLPSSSTLPDGIFVPKPSSRVPWLWPHGFPGKKGVHASMKVIVEHDPTAAAAHGHGAEEGGEGKKLFDKGRTGKELDGGGGGGAGIGIGIGNGIGSGAGGGEGAGKSRCVVAGGVGEERAVHGSKKSSGETGEGTGMGGRQREASGNGSIVGGLENAEGEKSVFPVEQEEERGEEGDDFDEDEEDEEEDDDDEDLQVSKTIEALDLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MI48</accession>
    <name>A0A2X0MI48_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C009g05731 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C009g05731</name>
        <name evidence="2" type="ORF">BQ5605_C009G05731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY84989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MI48"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY84989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="425" mass="45594" checksum="72007A3F16217244" modified="2018-09-12" version="1">MNGPTRLDPAPQTGESGPISPMPRGVRGPRFLMQLKVKILISPSSLSGNEGPKIQHPHQYEGAEMMASPRPSMSSARVQSPRPKHAAGAGTDQSGDHRPGVRGNEVHHPLPFPGRRDYFDPNRPASPSPAQASHRRFSLTTLARRTSTTTKPTTIPKPSPPKTPPSPLSSVKQNLKKSWTHLNLLPRGSPNQETKSGIPPRQRLSTSSSRFVEDLRNRKISSPFVSGPRLGGLRGVENAGWRSSFDGATVVGMNELGQLERPSTNPNSRNARHSFQSSLRPISNSTYPPPRHSLETNLGPTLQPNPPSSTQRTTSLSPPPHSRTPTPTPSNPNSLGIKRKPAPPITPSLIRQTTMSGGSPNSSQSVLAPAKVAAVLQRRSVSGPGPDGVLRRPVLQEVQALTLRSSMDGEGDGERVRTAEEGGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIJ0</accession>
    <name>A0A2X0MIJ0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C011g06537 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C011g06537</name>
        <name evidence="2" type="ORF">BQ5605_C011G06537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIJ0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY12541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="62" mass="6789" checksum="7FD1A438515974C4" modified="2018-09-12" version="1">MSSPPSRASATASVRLVTMRDRDTPADRRERAQAHQKRTAANTKAADNKRRRLDVAVGVSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIS7</accession>
    <name>A0A2X0MIS7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C036g11514</name>
        <name evidence="4" type="ORF">BQ5605_C036G11514</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="FQNC01000063">
        <property type="protein sequence ID" value="SGY95765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIS7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF95">
        <property type="entry name" value="HELITRON HELICASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="131"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="376"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY95765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="436" mass="47268" checksum="1CF440EAEE2FBE27" modified="2018-09-12" version="1">MENFQAAIPSNVLFECQPSSCFFTGGCGRVDFVRLRIRVHGTLNKTRSVNSGSPSRGRSSTARFGGVTVVLTGDPKQCLPVILNGSVWKSEAMPSRYSTARFGGVTVVLAGDPRQRLPVIPKSSSAQIVNFVDAPGGTGKTFLEETVLARIRSEGTYALAVASSGIAALLLPKGSTAHSRFKIPIDMFDDSTCNLPKQGQLAELWDEAPMQHRRCFQLVDRVLQDVRSSVARLGGLTVVLAGDPKQCFPVIPKSSPAQIVDARIMNADFCRDLSIGSSELETGRQTKQKTIVFPRELLLPATTRNSSGLIRRVYPVDHINNMVLDLLPGDAQTLYSADLDAFVAVDVAAQAFRSGPAHFSARPCLCQITTNQSTSRRSQNDCVGQSPPPQPTLSRSDDLQSGTSGERVQFAQGDIHPPHSHRLHCVHCRELTLDMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIX0</accession>
    <name>A0A2X0MIX0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C038g11693 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C038g11693</name>
        <name evidence="3" type="ORF">BQ5605_C038G11693</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000061">
        <property type="protein sequence ID" value="SGY91735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIX0"/>
    <dbReference type="STRING" id="796604.A0A2X0MIX0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057678">
        <property type="entry name" value="DUF7918"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR EAF N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25534">
        <property type="entry name" value="DUF7918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7918" evidence="2">
        <location>
            <begin position="22"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY91735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="343" mass="37920" checksum="A078D6A43A6C43F6" modified="2018-09-12" version="1">MAPKPPVKRLEAPGLPGFFAWVVVDGVDAPIYDPHIEGNKAVGYIESKERKSYAVKFRDERLSAPTDLDAWVYIDGTKQRGILAKKDHARYGYPLDHPARETILSGRLASKTSERPFVFGKIRLTDDDNTATKVEETIKNAGTIQVRVIQSQHLGPTLRDTVSYNDNPDPPVLHEKSKKASLSHTTAFGSTVPLRGKLHLCDTVALGDLSSPMGFIEFRYRARILLELEDRIESKRSRPNANSAPRSASTIQNPGDHLEVSDSSSESDDLASASSAESEPSESEVEGLTPEEKVEARRLKAELAKLNSKRKKKRKMKKQGGADRKPKIKPEVKSLGTIELDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJ47</accession>
    <name>A0A2X0MJ47_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C037g11580 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C037g11580</name>
        <name evidence="2" type="ORF">BQ5605_C037G11580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000062">
        <property type="protein sequence ID" value="SGY93266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJ47"/>
    <dbReference type="STRING" id="796604.A0A2X0MJ47"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="618"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="699"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="715"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY93266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="729" mass="81362" checksum="F0D10E3DC7CEF50D" modified="2018-09-12" version="1">MKRAARRLVPLASWTESPHAAAAATSAALAQRHLSVAAGANLLNTAPSSSSSTSHHQQFTSSSTWTDSWSRNMFSLASNSTLNSNASSSQAQQPVNAQARPEPSAAPTTTTTTARDLLHEIQLDMPNPTRVWPLFCQLEAEGQTYLLPLQELHRLLWAIEVPRRAKSAPPLSVHEATQLANAYSSQVQLIRMRIAQRDPEAKMLKGDFVSMATAYQMLNYAPAAMRVWDESIASGLKFRPLHYKRIFETMVGWIDMHEVDGGKRLARTAAQPLVPKAMEMLAELADNPKWTDACLAPFLRICIRGGNSHVFSSTIKAVYGFDIDMPGAPIEFAPGRRPIGQEQVALILEMLLESRDLSSMMAVFESFDDPLPVPSLPDQGMEGGSFVQFFANSFSFGRKPTPAVSVPPEHTAGAKPPVVPGPHPIGPHAFAFVIELAGQVGNGAIMRHYFYQLYKRWSLIVDAQLKELEQVITPEQTLSESNSTATPSSSSQLSIKLPLTADSRRYTIPWTILQSMVRHARQNYDHVTLRFLRKRSIRVLQLMDAQSTRLTTLLQSTKLREDVDATLYQRVAHQIDRLDAERKRMLAMLELVKLDSNIYTTYWDVRRKETRLSKRMRQLHDHTHNSGDPSAGPRANKSQMAKELGAMRSRVRRKQSQVLLARILLVKHRLRRLTYLGKRRGNKEVDDWFEELGKLTRKRDGGGMGTPLPSDAVASDTTQTPLNEVTATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJD4</accession>
    <name>A0A2X0MJD4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C002g01025 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C002g01025</name>
        <name evidence="3" type="ORF">BQ5605_C002G01025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY29195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJD4"/>
    <dbReference type="STRING" id="796604.A0A2X0MJD4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047574">
        <property type="entry name" value="AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039683">
        <property type="entry name" value="Lsm12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019181">
        <property type="entry name" value="LSM12_ABD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13542">
        <property type="entry name" value="LSM12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09793">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00995">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52001">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AD" evidence="2">
        <location>
            <begin position="133"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS52001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY29195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="237" mass="25683" checksum="1FB4A1199F2E6090" modified="2018-09-12" version="1">MTSTSTTPRTLSAGSSIPFSALAQYVNHPMRVLLVPIPVTSSTTPSTPANGLPSRTAQGTLYTVDHHTQCLVLTTPSTSSTSTTNKSSSSTTTTRNYSFHLFSSIQSTTLLSTLPDPSLPPLSTSTSKNTPDLRMDQEEMKLRIEKGVAALVKERSRKPPQGVVVTPETQALFDGLAKTMPVRWHGAQIIVMDQVIISPPYTVDQVKGEKGAHEGVERVKKVLQGERQRRNNKPTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJZ2</accession>
    <name>A0A2X0MJZ2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01195 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01195</name>
        <name evidence="2" type="ORF">BQ5605_C002G01195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY30940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJZ2"/>
    <dbReference type="STRING" id="796604.A0A2X0MJZ2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY30940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="514" mass="56547" checksum="E6EE3F8F098ADCD1" modified="2018-09-12" version="1">MLGLVPWLSLYLRTPSTPMEHGSSLAMTASRAATTPNAFDTIAGCNEPTGYARTPHSDSAQSPRPLSAGMQRSAMNASERECDSNFSNHSLSYSTYHPPISSAGHGQLLSNDHVLVPRRHESGAAATLISFGQRGNYTHQDDPHASMSASAWYNRVPCSTSAASYPTKPVRAMSSPVTRVESEPSRARSPTASDPLPSVPSGEWFEQQDPSRSADPSRSNSQPEVEKINPLAPKRPPNAWICYRTARCKAMRAEGAPTLPQAAIYYSYQPTRKPKSGGTPARSGRRVSSSKRKERRSTAPQLDAPTSEKQAQLPSDPTMVPTSDLNPEDTLVSEVSAQKNSRWIIDEYNGLGGGRRSASFEDARSSGALSPRSTYSQSYYDISSSEIYREDEEAYQYRSMYEVSTNHQQRTWYVPTSAPQQPIPCETSTTARYFRADPCLQPVLQASMARSLSFAPQHLHLLFPDHRSASYEPAQHSPTAPFPIMYAAGPAYMPEASKHPWKEINLPNGYIRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MK75</accession>
    <name>A0A2X0MK75_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C034g11328 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C034g11328</name>
        <name evidence="4" type="ORF">BQ5605_C034G11328</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000065">
        <property type="protein sequence ID" value="SGZ00166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MK75"/>
    <dbReference type="STRING" id="796604.A0A2X0MK75"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032854">
        <property type="entry name" value="ALKBH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212:SF4">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="13"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="317"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ00166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="544" mass="60445" checksum="47E2C990CA3CE05E" modified="2018-09-12" version="1">MSSSTVTEIKPEEHQEAIDTLAAIFPQLPRSTLQRFFVASSRDLERATTALLGRDDNVKPASAAGRLVTTWDSTGLRAVKRKRIEKLDHWLKPASSSTMRLPARSRGEASTRPTSPKREVETTLTSTVDAYQLLQRKPTSKTPKLSATSTTTIPLGGLANITTGAGTTPTHLPPLTLSTPEAIAKHTRGRIILIPNVLPKELASMLFQSMLDENDGRAQEGSKKPWERNKWYMFDREVESPHTTSFYLEKAPSVGDEDLVNATNVALSTHWYNGTKRQGRYFTPLMDQARSLIQPLVNLILGSRRRHPLEYTAGEWVPNVAAANCYRGAKESVGPHSDVLTYLGPFPTIASLSLGCTRPFRLRPFMPLPGIEMRSLDLVLPHNSLCLMLPGTQEFYKHSIQPVSALDTFRIPGQEERYRERINITFRHYRPDYAPLPVQTSVPLTGGAYAGTPHCQCKLPTILRPDGKGRARAYLQKDKPKVDSDVAEGQEGDDMVYFWTCSASQVVPGQNCGFWKLLSEQQEGRGPWFKGKSAKPSRLADPGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLT4</accession>
    <name>A0A2X0MLT4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C012g06879 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C012g06879</name>
        <name evidence="2" type="ORF">BQ5605_C012G06879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MLT4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY16466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="50" mass="5447" checksum="1AC44837DC0F95D6" modified="2018-09-12" version="1">MLCRMGPNNVSPSHRVTFLLLLVHSGLVVVIVTTSFLPCDPCETSCLCNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MMA1</accession>
    <name>A0A2X0MMA1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C012g07019 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C012g07019</name>
        <name evidence="9" type="ORF">BQ5605_C012G07019</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MMA1"/>
    <dbReference type="STRING" id="796604.A0A2X0MMA1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050925">
        <property type="entry name" value="Rhomboid_protease_S54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731:SF14">
        <property type="entry name" value="PRESENILIN-ASSOCIATED RHOMBOID-LIKE PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731">
        <property type="entry name" value="RHOMBOID PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="8">
        <location>
            <begin position="114"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY16886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="287" mass="31617" checksum="3DCD1695D178655B" modified="2018-09-12" version="1">MSVAALHTNSDTFNRRQALERWGMPPRRFLDRGLDPILAASRNNELVQRLGFFVDAFGRPGQVALHSWISVSEAKRTQVGLIALFGVVFTVWNLKSARTLAVKYLWQSPLESRTVTLLTSVFAHKTLPHLAFNSVALFSIGSSCSAYFDRMDCALPRSTSRYEYIAFFITAGIFASLASRLYSLTFLLRRSSVLLPSLGASGAIWGCFVVTALAFPQASVALIFMPFVQVPIGSACCAMLVVDALGVIRGWQIFDHVAHLGGAFFGLLYYVKGHALFEQLRQSLLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MN05</accession>
    <name>A0A2X0MN05_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C026g10257 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C026g10257</name>
        <name evidence="2" type="ORF">BQ5605_C026G10257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ28032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MN05"/>
    <dbReference type="STRING" id="796604.A0A2X0MN05"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ28032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="333" mass="37023" checksum="C110A1706AA76387" modified="2018-09-12" version="1">MTAPRGFDLPSDKVLRLRRSIYGLKQAGRIWNRHIDASLRDLGYTATGTDHCIYSRLDDCQRSHYIALYVDDLLMISPDLAEIERVISGLERRYGVKHLGPAEYILGIQIRRLADGSIALSQERYIMDVLARFHFDTTTRGTTVPMTPGLSLTAIPGQGTEQIKSWYLQAIGSLLYISLGTRPDIAFAVSYLARFANNPGQRHWIAVKHVLRYLRPTYRNELLYARGETRITGVVGYSDANWGACVDTSVSTMGYVFYIAGSAVSWSSKHQSRVADSTTDAEYLALSHAGKEGIYLSQLLEELHVQPVAPAHIFTDNKAAAAVARDPVRVTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MN07</accession>
    <name>A0A2X0MN07_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C029g10631 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C029g10631</name>
        <name evidence="1" type="ORF">BQ5605_C029G10631</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ14964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MN07"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ14964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="75" mass="8147" checksum="E0745E4BB989AB90" modified="2018-09-12" version="1">MGRGGHWCTRPVPTSNRAKKHKSCLNLPARGSSFGWVNGPADLTAYCKEGRGRARLSPRRQTLAAKAEKTIVALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNJ8</accession>
    <name>A0A2X0MNJ8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C021g09327 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C021g09327</name>
        <name evidence="1" type="ORF">BQ5605_C021G09327</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000083">
        <property type="protein sequence ID" value="SGZ21055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MNJ8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ21055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="203" mass="23206" checksum="2E9663DC62052708" modified="2018-09-12" version="1">MHCPCHSRNSLTVCAFCGGSPNLAKLDKCRPMIVKQSRIQKMLRWLINESKDSAHSAVSFDGDCTARSTHWFRPGCAQPDLSSFYGGFSFHFDFGFRLGCSPIIGSTIRGWRLSRALLFEHVHVPPPPTDEPIHSWLLFKKALRYLNQDKPTYVIPTGDAPLWEPSDELMLSKLWPLHTSIPKRKRLESQQHCSKSTRMLRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNW3</accession>
    <name>A0A2X0MNW3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C051g12517 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">BQ5605_C076g12934 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C051g12517</name>
        <name evidence="3" type="synonym">BQ5605_C076g12934</name>
        <name evidence="2" type="ORF">BQ5605_C051G12517</name>
        <name evidence="3" type="ORF">BQ5605_C076G12934</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000096">
        <property type="protein sequence ID" value="SGZ29490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000127">
        <property type="protein sequence ID" value="SGZ34653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MNW3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036058007" evidence="1">
        <location>
            <begin position="38"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ29490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ34653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="78" mass="8690" checksum="90EB3A4DAB607682" modified="2018-09-12" version="1">MSFDMCLCLWYLRGCAERAGLFFPRGCLLLVAFSSLALHCGPDFSVSCTLTYRKALLPRSHRFCDRTEAEGAGGYWGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MP03</accession>
    <name>A0A2X0MP03_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C003g02497 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C003g02497</name>
        <name evidence="4" type="ORF">BQ5605_C003G02497</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY41328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MP03"/>
    <dbReference type="STRING" id="796604.A0A2X0MP03"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002671">
        <property type="entry name" value="Ribosomal_eL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038526">
        <property type="entry name" value="Ribosomal_eL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064:SF31">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL22A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01776">
        <property type="entry name" value="Ribosomal_L22e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY41328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="121" mass="13254" checksum="EFD1CFA5CAA3C842" modified="2018-09-12" version="1">MAPVSALSFPRSIPAHFAPTPLTVCRTNHVYPVSLIFPLWQVKSKKSATTAANSHKFIVDFSGPANDKIFDAAAYEKFLVDSIKVEGKTGQLGDDVKIAKEKEGQLSITSQIPFSKRYLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MP81</accession>
    <name>A0A2X0MP81_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C017g08331 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C017g08331</name>
        <name evidence="5" type="ORF">BQ5605_C017G08331</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY19819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MP81"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY19819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="261" mass="28735" checksum="467CDF7C1351D6B2" modified="2018-09-12" version="1">MEGEGADWYIDCRDKVKALKLWPEFAQEVKARFINEKTGLEAKHAFYNAHQTGTLSDFVATLIAARGQAGSIGGTQVISDELFKDHLLHRCDELLYLCATASPSFDVTKFTMNQLVAYLQSLWEAITLERATTGVRRMGLRNDQVRQEQNNSAAHQTSGRPMAGLDRTPRDKALHEGRCFHCDVHGHIAADCPSKPGTSLTPAPSRPTPGPRMVAAIREYQESGDSTAFVGISSDSEEDDARWLAFQTDKEDACSFGLEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPM9</accession>
    <name>A0A2X0MPM9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C001g00082 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C001g00082</name>
        <name evidence="3" type="ORF">BQ5605_C001G00082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY43919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MPM9"/>
    <dbReference type="STRING" id="796604.A0A2X0MPM9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11296">
        <property type="entry name" value="O-FucT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="10"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY43919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="673" mass="74121" checksum="C23AA2F73BAE77F2" modified="2018-09-12" version="1">MERHFAHAAVEIVTDPSADPSHATASKSPHMPRAGGATPRLGFQARMGNSVDSSATLLNLPQVTNLPYIPGSPDESPYRRPRSSGRQITLRRILRLGTSESGVLLLLVTIVVLACCFILLGERNEGDLVQGYHAAWNSLWAAMPDPLAAMLGRGVGAGAASTTASNPTEGSVLRGSGSRNVATADQEHRGPSKLHYFTHATPQANFWGQLRPGRRYLTAFTYGGHCFLLGPANQMLGIQKLLYLARITSRVPIIPTMIPDHFVGYPADFTEFYDLNRFYRETGIPAFVMSGIKPGHSNWQDPPNEEIGCWSVQEAVVGYANAFEHTLFHHGFVTNLWALPPLTKATGGQDIAFDAMRLFDFDQLARSTWLDKVQREMLPQNETQATLPVTDLRGRENNTKYMFNPASGAKPNDKVLCFDNTIFLGAIEFPEDAAAEVEQGLSGSASGVVPEPRLTGEDLTWKEVGQHIHFNDEVRDTVDQYLARLFDVTSPKEIPPYLSVHLRRGDFAAFAGGYTKLEGYLAAIKRVQAKLQLRIDDPSSWTSPGKSHFTPRSRSNVVVNFPIVATTDEDMDSDLVRQIRDLGWKVVDHDAMRTIETKGAWWPTVLDMAILAGGSGFVGTERSTYSYMTGVRVKYWQEGVVDFADVNLQVADLEAPLQEKAARAEGNPPQKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQ96</accession>
    <name>A0A2X0MQ96_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C023g09761 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C023g09761</name>
        <name evidence="2" type="ORF">BQ5605_C023G09761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ25051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQ96"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ25051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="335" mass="37447" checksum="B48FC07833F511A4" modified="2018-09-12" version="1">MAEPTLSSPHRHLFLRRGKCAGLEPRSNHSSPTFPSATTSAPDGRRTGHLSTCCSQGKVQLPPLSGPIPSIDSCLKGRIPALKDPACFGYFDAFTIDSAHSRRPESCRQSAPNLCQNMAHLPGRGHRHSTWTRRRRQSHTKIYFDQAQFYAIPTPTREIVDLKTLFSRCTVIDVPMVGPNHYYFLQGKMASTPTFLFAGSTKPGRQSPETESRSTMVSNCARYLPVSVWMTKTKRRTKTATMRMKTARKGTKRMVMANVRFFSSFSDVPFWVEVASLAFTILCALVAKSDEYFSIPHCTQRPFLESNLRLTTTQGINGLTPGQPLSSVEEVWAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MRG0</accession>
    <name>A0A2X0MRG0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">BQ5605_C027g10365</name>
        <name evidence="17" type="ORF">BQ5605_C027G10365</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="14"/>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MRG0"/>
    <dbReference type="STRING" id="796604.A0A2X0MRG0"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23285">
        <property type="entry name" value="beta-trefoil_MIR_PMT4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000044">
        <property type="entry name" value="Dolichyl-phosphate-mannose-protein mannosyltransferase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF51">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="324"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="704"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="742"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="772"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="822"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="432"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="501"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="564"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="15"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="SGZ28531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="874" mass="98242" checksum="F102599ADBAB9298" modified="2018-09-12" version="1">MSNDKLLHRKAAIASHANHLSPQSQVFPPKYDGVPSDTQPLMAGTSASTATASSSTLPRGRERDDVGLAWRDSSTNPLRRNTPSKPSGVSSTSVLIFQNAITLPAACLRAVALTCPHLWQPIALAPHPPQSSDDLANTNASVEWVVLGLIAIVSAVLRFWRIGHPHSVVQVILASILTANFDEVHFGKFASYYLRREYFFDVHPPLAKLLLAFAGWVIGHDGAFEFENIGDDYIKNKVPYVALRSLPALLGSLVPPVVYAIMRESGYPKAIAILSASLVLFDNAHVAQTRLILLDAPLVLFMSLAFYCYIRFHKLRYNEFTKSWWTWMILTGVFLSLTISCKMVGLFAFLTVGTCVLIDLWGLLDIKRGHTLKHVVKHFAARAFGLIVVPAIVYLFWFWVHFKVLNRSGTGDEFMSSAFQQTLLDSPMTLTAKEIHYFDTITLQHRTTKSFLHSHPDRYPLKYDDGRISSAGQQVTGYPFNDTNNHWIVEPTGEIPESGRGRIVRHNDIIKLRHVVTNTTLLTHDVACPTMATNTEFTTWDGVDLAAEPNTHFQLEIEEAHEGSQWMSKSSHFKLIHVPTRVALWSHTDPALPDWAFKQQEVNGNKNLKDRTTLWVVDEVIPDPDAAEMINLSHPKKEKTIVQLSFLRKFFELQIAMLQHNAGLTDSHPYASGPINWPFMLSGISFWTGQSELKQQIYLIGNPASWWLSVIAMSVFVGILSADRLAERRGMYPIPRPVRNRLYNSGGFFMIAWLYHYIPFFTMSRQLFLHHYLPAHVCSALLTGAVFQFVVSETINSAISVPPTMAIGATTFRRQRKQFAEVGKGMILGVMGIVGLLVVGYSWFAPLTYGFPGLEPEQVNHRRWLSTWTLHYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MTH0</accession>
    <name>A0A2X0MTH0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C042g12030 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C042g12030</name>
        <name evidence="3" type="ORF">BQ5605_C042G12030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0357 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000116">
        <property type="protein sequence ID" value="SGZ31887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MTH0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018559">
        <property type="entry name" value="DUF2015"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28023">
        <property type="entry name" value="UPF0357 PROTEIN YCL012C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28023:SF1">
        <property type="entry name" value="UPF0357 PROTEIN YCL012C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09435">
        <property type="entry name" value="DUF2015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ31887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="114" mass="13013" checksum="883DC878D23BBB73" modified="2018-09-12" version="1">MVCLFLIWHFRAKYIDHLPPALSSRLRYYAPLSTFEDAAEQGFSTAAFDLSGNMAGDSRAGLDDRTLTEVRRIMEEKRCNFDEARVIHTNRMFARNGIDPNGYPLDPKAITRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MTP9</accession>
    <name>A0A2X0MTP9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g04298 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g04298</name>
        <name evidence="2" type="ORF">BQ5605_C006G04298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY57683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MTP9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY57683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="342" mass="38058" checksum="98FBA7A09E0F53EE" modified="2018-09-12" version="1">MAGSASEKDKENQRRNGKGTGLKLGLSLVRAKKYIDADGMYARKDKGNMGLRDYTCKRGQIDKIYYNWVRSVVRDALVVAGIRTPTPVQLYGPLAEINQEWSPNHDLPENYNLKDAFRLISAKTSTNTVLWGNLSPLKQREIVKYIRERAGFLAVTSGDWLYEELVIDVLANIRSAWKLAYDREVCRLAGIKGQLSKADIATLRSRHGEGPSRKSQDGVYSASDTGTSDLEEEEVLATRNRTLVPKKRGARQGAGSPQLSQETQQTSPHVGSSGQRSTPAASGVRGPGPPRNKKKKTEHNPNRSQQTNPKRDLGNGRAKEEEDEDQGQDEEEVEELERSPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MV97</accession>
    <name>A0A2X0MV97_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g02079 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g02079</name>
        <name evidence="2" type="ORF">BQ5605_C003G02079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY38821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MV97"/>
    <dbReference type="STRING" id="796604.A0A2X0MV97"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY38821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="599" mass="66911" checksum="67B1FDC743122D58" modified="2018-09-12" version="1">MTTMQPILALRHVYEPAVQLCRTDGVVSAMANSTLGSPPHHLLRKGECAGLESRSNPSSPTFSQGKVQLPPPPQPNLEYRQLLEGSDSEAKAFRENARSYNNAFSFTSLAAHWDQTQVGTLGPPVFRVFSRLYHRLGALIPTVTQRPAFAQTWLIDPAEATDTRLGPDGADSRMQRSTLTKVESILRTGNRFVREFASAKAHAGWDTAKEWILRLCLPPGRDRRTHNLPTSSTEMAMLICDSDTNTGDRGRQDLILQVHGDRCPEGRPKYQVVSSLHPSAMPLRYPLLFPAGEDGFHPNIPRCGFHQAGPPIARNREQIDNGANCASYLPVSVWMTKRMVMVNDEGQVKGSRSRWRVSRSQFFTTCQRRRVVLNPALHPTSLPGVSIPGCDGVRCQPWKASAAHHDDVRLRLTGNQGCTGADTACNRPDLIARVFEAKSSNKRHAGCFGDEYKMNGFCFFANRGLYTELNNYRAVCFGLILAILATSWFTTLAQEYAMRRHLIPETQTAVQSGNQQRDLTSYLSQIQAWAYRHDETIYALVRDQKKSFDLLRAEAGYDAYNFFGLPKAVEDFDRARLAQGRFFVKTPYGPTEPFTAEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MYU9</accession>
    <name>A0A2X0MYU9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C008g05005 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C008g05005</name>
        <name evidence="3" type="ORF">BQ5605_C008G05005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY78979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MYU9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF270">
        <property type="entry name" value="FYVE-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="1001"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="734"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1135"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="474"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="734"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1138"/>
            <end position="1147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY78979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1426" mass="152203" checksum="9236719574AF7711" modified="2018-09-12" version="1">MVMLPALQPKYSSRSGGPQRPRISTSSIVHVDPTNSAASMRVGDGKARGPSPQPLGSTATAGAPLASSANREVTTQVFMAQSIQPNTNSGFPLRPALMPRTRSSPVPDRNRSASEHEDLPPPWRVDAPTTRTRLSPSPRSASRSFVDAGEGYVDFSSTSPASSMSSVATRRFSPSLETGVSFPASSTSGLNAGQRSRLSQALLDVSADISSLLPSRPSSPLSQGTTGLVQAKVASDRRATSMSSLDSNTLETIARPLERPSSRGTFASSSPLSTAAEARQLERTPSVPGSDDSLCHSISTGSASGWSPFFSPHSAASTAARTSFASNVSKEPSTSPPLGLGILEIQASSTVTTSRSLELDSSGHRAPPLQLAHSSRSPPVATPKPEHAFGDGDLDISLAELQRFAQSLPSPALSMKPSYSQGSASNWPPPSPGILTSFQVVSPVLVQTLSPILSVAPLSPSPLVEPDSECRSSVATVSSTIASESDGGSGGWNGGDNSSRSTAASELDWKMGAQETHNDQDNAESLGPRSTIINWTGTEIDMMAVLPMSEWGVRLDVRLSCQALMSYAGATTGTTHLLLSHMTPSAAISSLLRKVLPSLNPGLTVLNLSHNSLHALPSTIASCASTLEEMSVSGNPIRDLPQWLTDFTRLRVFLADECELSSISEVVNAWPALETLSLRRNRIDRLPPWLARSSNLCRFDIDGNDWSGEWLQVIAPLLTDERAVAGTIPSATEGFWSGSSTPSGGWPDSNPPHASAPVSISLDPGQSLKGSRSVSASSLQFPAPEVGGIHAGSVFGKMIKTASSRIRSRSISGKKLSQLDRAQSEPTMPLSVLDIRPCRGEGRKRRSFLLTPCDIANISEPEITPMPRLASLGGQNKPSGQDAATFATKMVDSNVDEEDHRAGLRIVMGYLRDLDDLTLGVKRNSFSTLASSQGSVRHSSSLGSIAFGQNGDSATVVRRAQSTRRNTSGRASTMDEFDALRQSLPGSTTSGPLKIRDDPARREAVVKEIIETEKTYLRGLEELVAIYVGPSAGVIDGKELLPAVERRAVFSNVEAIRDFHAKIFFPDLLEVVQSATKASASIRLIDPSHRWLMAAIGIGRVFARHAAVLKIYSAYVNAFDGALTRIQSWIIDAAPSRPGTSSGSREASTPGLAANKPDGSHGGCALTMNQKKRIKAFLKRCKSHPDHSQISLESYLLLPVQRVPRYRMLLESLLSCTPYILPVGDSCVSPHDTASPLVPHPTLYEALTLVSEVAVSMNERKRETEGRAELLYWQGRIGHRFRSPLVQPHRSLIKSGAVNLVRTVKRAGGTVAQKWSSKDSGEYLVQEVGKLSLIALLVTDLLVLVKAPPPGVMDPHAQVDLYTVIRLSPAIERGGTFEGPASVYGADHTTLRIVCDTRAILYLDCSSVNEASTWARLINVQWELNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N311</accession>
    <name>A0A2X0N311_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BQ5605_C004g02844 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C004g02844</name>
        <name evidence="12" type="ORF">BQ5605_C004G02844</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the helicase family. Dicer subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY68060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0N311"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18034">
        <property type="entry name" value="DEXHc_dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.380">
        <property type="entry name" value="Dicer dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038248">
        <property type="entry name" value="Dicer_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005034">
        <property type="entry name" value="Dicer_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF37">
        <property type="entry name" value="ENDORIBONUCLEASE DICER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03368">
        <property type="entry name" value="Dicer_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51327">
        <property type="entry name" value="DICER_DSRBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="24"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="323"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Dicer dsRNA-binding fold" evidence="11">
        <location>
            <begin position="516"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="8">
        <location>
            <begin position="932"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="8">
        <location>
            <begin position="1101"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1440"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1441"/>
            <end position="1454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY68060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1527" mass="170350" checksum="4E9625F9898563A3" modified="2018-09-12" version="1">MGDAAVADAAPPGLHVPRLYQEEAMDAAVKRNIICRMDTGTGKTLIAILLTRHITSQPVLASEPQVHRLVVFIVPTVSLVDQVAAVLRRQTTLTVATFIGAMGVEYWKREQWVANLANAHVVVMTAQIWLDILTNAYWDLERVSLIVFDEAHHCSKRHPYAQIMKDHYHPRKLAGDKVPRILALTASPIFNAKSPEKSISELEANLDARIYEVSSRHADSIQNSASKPKERLVLIAFQPPSDGITPSETIFLREVEHLTHLELDRRIPARIDLVRQKFGKAGLAIYLSQLAKDLKLAVSVQDKLEALVPASIDVDNLSTHARALVDVLAKYRDRPEFHGICFMEARHDTQILTQILRRDESFDWLRPAFLVGHGDQGKAENLASSGMKIAEQQRVVAAFRTGEVNLVCATKVAEEGLDFRACNVVIRFDGLQTMTGYIQSRGRAREKNSDFVVLAQPGSIEEEVFLRCQKMEPELRAMYGSRIELPEIDEDDGPELPDTPVYRVPETGALLTYGTAIPLLSEYCSLLRADTYSSWQRPDYKIEAQERDDFGCTQWKCDLATPMIHAFGGLRTFHSEPCPSKRVAKQSVAFQACLALHTVGAIDKWMLPIRERLGHSGKDAYGRALDDFEKPKPEVRLAFHNLLGVPGRSQEATETLHVVELSPAVGEPYRIGFVTDRCLGSILADAKDLVSPEGDKIVMKVVAAQAIQWNSQDQRQARLSLLQEVNRQMTRAVINRRIPTDADFELLWAPLEQTSSSIDWDMLDNAFVPVDTNAVEPGSRIIVLSSGTCHVARLDEVRKDVTTRSDSMAIDGTAQKKRLRLIERYPAWWIFIKVAYRYHGLEEDTDEQVLTVTSVPVAIPNYLCSPLIKEGEQEEFVPRTTTRNYPVSMCRTCKLDERFWAFIPMIPSLERLITDILRISITAELFDIPMILETVGDSFLKLASTVHIYFQFPGADEGRLSVVRQNSVSNTFLRALNLAKGYSNAILARKFLTAHWIPEHAELPPPEPSAEESTRGVGPKILAEDPRIAAADAVLKKIGRKTLADVIESTLGAAIKTGGMPLALRVGEQFGLCFGGVTPWHLREGAARIAAIPATEVPVGLLDLERRLGYKFEQHGRLLLQAITHRSCRAATTYCYEREEFLGDALLDYWATDRIFKAFENATPRHLTFMRALLVSNPTLAFLSIRKLDLHKTILHGSASLELAMLEAQEQAESMTWAMVLTGDMTWLWSPPKVLGDAFEAILGAIFLDGGCRLEPVFATLDQIYAEVMPLMRNVETRVRHIWTKAISKGLTDMPMFSDEQDPLSRLLIHSQANGCQKTRVKVTRVPDAVVRTYEATAVIHDVIIATRLNGSQNVARQLAARDALELLEKESKEQAAPTKSFVEAPCTCREEAEAARLEAERLKRVEELDEEEHLIDDVANDGGLADELAAREAQLRTLGAEEEEEHDEDGEEEQSSKPEVVSKGHAAADVMNVDGTEPISNGAEGERMIFCSNSTPMKGRFAPALKWATSISLDSPARAFKRVRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N383</accession>
    <name>A0A2X0N383_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C032g11014 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C032g11014</name>
        <name evidence="2" type="ORF">BQ5605_C032G11014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000067">
        <property type="protein sequence ID" value="SGZ03706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N383"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ03706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="96" mass="9858" checksum="94DB2A3CB5D38702" modified="2018-09-12" version="1">MVADIFTKALGPKVFSTHCYALGLRTRHPRLGSASHSRGGGCKESTLSSTEAPRSSRAPASPPPCGGDLGARDCLSEQAPADSGARPLGRPLEVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N4A3</accession>
    <name>A0A2X0N4A3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C005g03286 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C005g03286</name>
        <name evidence="4" type="ORF">BQ5605_C005G03286</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SRR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY73364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N4A3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012942">
        <property type="entry name" value="SRR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040044">
        <property type="entry name" value="SRR1L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28626">
        <property type="entry name" value="SRR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28626:SF3">
        <property type="entry name" value="SRR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07985">
        <property type="entry name" value="SRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRR1-like" evidence="3">
        <location>
            <begin position="112"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY73364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="375" mass="41793" checksum="F6AF5EA8560307FC" modified="2018-09-12" version="1">MIAERMHGDSQKDQDTFTPVTYKKKARNATPNGGGLPLPGQRNSTPRTASSSSTRGKGKGKSVIVRERTLAERIEGRRTTFVTSKYLEQCKSLLRNALDHDRPIASTSQSTACPTPTCAVCLGLGTLTDSPKSQEQYLLLEALQDELGTLLTKPTEVYDPVFDPQDIEYLVARGLLPLQTEHDLIFDTPTLLYMPHCPRSLFDLVLERSWSRKGLKNLIILGNRLEMYDDPYVMDRGDSLRSRKVILKGTHLSRRHASATSSAKSPFIARAGQPFFGVSLIPACLGNDLIRCLPLHTAPLFTAIPLPPTKDHFQAFNDLALQWIPLERLDQIPDNFFDKALPPSIHNDRLENGHEKAVHSLKGDHLSEALERVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N6R4</accession>
    <name>A0A2X0N6R4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C008g05347 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C008g05347</name>
        <name evidence="2" type="ORF">BQ5605_C008G05347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY80281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N6R4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY80281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="105" mass="11443" checksum="234FAC3DBC0DEC99" modified="2018-09-12" version="1">MATDDHISLVVAIGVERIIVTTTATTVVPIITILLILVGIIIIIIIRNDHSTDSPFFMSSGWRVALRVAGLVPIYAMDLLEPITETEFEGLRASIQESKGRLVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N8M3</accession>
    <name>A0A2X0N8M3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription elongation factor 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C025g10058</name>
        <name evidence="12" type="ORF">BQ5605_C025G10058</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 10">Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ELOF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000087">
        <property type="protein sequence ID" value="SGZ27114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N8M3"/>
    <dbReference type="STRING" id="796604.A0A2X0N8M3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.190:FF:000001">
        <property type="entry name" value="Transcription elongation factor 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007808">
        <property type="entry name" value="Elf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038567">
        <property type="entry name" value="T_Elf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934:SF0">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05129">
        <property type="entry name" value="Zn_ribbon_Elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="84"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGZ27114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="210" mass="23691" checksum="80FE487B630DAA25" modified="2018-09-12" version="1">MGKRSSAKKPQTRVKLTLDKTFKCMFCQHNGTITCKIDNKTKVGRLDCKDCAQHFETDINHLTEPIDIYAEWIDACRAVNPEGTRLQHRGQAPAVVRSNPTSTQGTNAAGGKKRRGSHDDDQEEEDEDEDDLPNPVGQRKKRRALDEDENEDEEEDEQEEDRDLPEPVGKNRVGVPQQVEEEDGDDDDDLPEPQGRKNRPGVVVDDEEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N9J0</accession>
    <name>A0A2X0N9J0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C034g11265 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C034g11265</name>
        <name evidence="1" type="ORF">BQ5605_C034G11265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000065">
        <property type="protein sequence ID" value="SGY99082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N9J0"/>
    <dbReference type="STRING" id="796604.A0A2X0N9J0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY99082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="499" mass="56341" checksum="93D017309BBF60BD" modified="2018-09-12" version="1">MTHDPFNTRAYGSLQDLTHRLVAQWLQKQGYSDTLAHLSSESEVPIPRLLNDKRYTLDPLLTDLIEDHLHRLAAQTANQAEAIPFKAELAQLVGSIPKLQLPNRLTTPIRDLANFLTVQVGLWPRRRWDSDTLSFKRYYDAHFHSWSFPKPASYAYVVSLNSNSEWIPSIYTTSVDSLKIFNRFDASLLDTIPLPSPIISFALHRRIGLFSTMQGSTHLIDLVTRKVKQVLRDHTKYVVGTLFDSDQGKWAMTWARDNSLRIYEFEYKQGETEEIVLEGEESDEFASEPEVRLIERHVVHTVTNPEAAVFLPGATHLVYTARDDHLLHEVVLPQTEDESNAWSTNGINLNENGDDCLQIALHPTLPILSLQTSTENARILLYAFHSPHRLATLHTQAIQTDYFQPKHVWLPSGNAVVVTSEDGILRIVGIGGRLIKEVAAHGAAVPDEEEDGLELSERAHVRRVKVKGSSVIKGVTCVEDEDGLSIWSCGFDKTVKRIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NE55</accession>
    <name>A0A2X0NE55_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">acetyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C023g09747</name>
        <name evidence="11" type="ORF">BQ5605_C023G09747</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="5"/>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ24796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NE55"/>
    <dbReference type="STRING" id="796604.A0A2X0NE55"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF9">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="9">
        <location>
            <begin position="22"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="10">
        <location>
            <begin position="295"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="7">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGZ24796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="418" mass="44335" checksum="44F402D589036E73" modified="2018-09-12" version="1">MVQATVVRRSLSNILKKNAHDVVIVTSLRTPIAKFRGAYKDMYPEELLSHVLKSTRKKLEAQGVDVQSGLVEDIHVGTVLMELGGAKSGRLASLDAGFPIVSGFKAVNRQCASSLQSVTDIAQSIQSGMIDMGVAAGVEHMTRDYGTRAIPVNISRFIKKSESQDAQDCLMPMGMTSENVAAEHGYSRQQQDEFACASHAKAKAAQDAGYLAEEIVPIKVRSVTPAEGDKPESTEIKTISKDEGIRPQTTMESLAKLKPAFKAEGTGTAGNSSQISDGASALTLVRRDVAEKLGLKPLAKWVGSAVVGVPPRIMGVGPAYAVPKLFERFGISKDDVDIFELNEAFASQSLMVIETLGLDIKKVNPKGGAIALGHPLGATGGRLLSSLIYELKRTDKKVGVATLCMGTGAGKATLIAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NJ11</accession>
    <name>A0A2X0NJ11_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C069g12864 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C069g12864</name>
        <name evidence="2" type="ORF">BQ5605_C069G12864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000131">
        <property type="protein sequence ID" value="SGZ35097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NJ11"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ35097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="508" mass="53769" checksum="BA21A67487F9ADCA" modified="2018-09-12" version="1">MQTGDPGSAPGARAPPPPASAPTSLPIAGTKETQATQVAGRTATYAAATNSSVVSNETPAQQQDRLARLQALPGILAAIQAVPGNRADRFVQAIFATPDFPSTVATALKFSALNATRNIINPFANALEVSLSHKSTGRASATDKGELVACVRTLLSPNTPICFDTGVPLSGDLEAFMPRITGLQHSSTFRTGVLHHRITVGFVSAEARDAALASAPMLVWNSANARFAKAHPFHRNMLEMRINVGVVRPPSKEQIVAAFQSIVQQLSTKGHSCQLVQVLRVIHVDTAKAYAHTVGDFSAFIHFDDASLFQHPTTTLKEILPSRMDLPTRGLDVTAVRHDYEKEAPCARCHFAGGGGPGQARGDERRRNGGGGEQTGVGRAATTTTNNIRPTANNNNTSEVVAPSRALGTDQLESRNRFAGLEVEGGQEDDIEEEVAGKEGEEKEQVKEGDEDTGAKADDEDSDSDGNAGAGIDKAGGDGKDDDKDDDEDDDKDEQDDSSEGSERRGMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NKX8</accession>
    <name>A0A2X0NKX8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C011g06304 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C011g06304</name>
        <name evidence="1" type="ORF">BQ5605_C011G06304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY11879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NKX8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY11879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="142" mass="15390" checksum="8F0870FDFDE864FD" modified="2018-09-12" version="1">MAVCINYKARHWEYKRSKSTGHYSTCCSQGKVQLSPLSGPIPSIDSCLKARIPALKDPACFGYFDAFTIDSAPLGAMIPAVIQRPTFAKTWLICPAEATDTQLGPDGADSRIQRSTLTKLDSTLRTGNRLVRELASAKARAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NLD0</accession>
    <name>A0A2X0NLD0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C011g06444 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C011g06444</name>
        <name evidence="4" type="ORF">BQ5605_C011G06444</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NLD0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="15"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY12260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="552" mass="63093" checksum="4F4BA4BB2C31ED4D" modified="2018-09-12" version="1">MSLEHEGSRSQMSQFRCNIAGCQRSFHHVRNLEAHLHVHERPRPLDRVLPTSSAAERSHLQVLRQQRSRQEFFRRRRRRQKNLRNGWPDCDVDGFNSSGSDYDDDSSSDSSSDSEYDHTLDDQPEWDARQKRKFRVEQPPLAGWACRADGQLCDKHTLPPAVPHAHLFDPNNVFYPFQDENNYRYALLTRSMSESLFNAMVTFNNSFLQVCSAEVVDAGTESYPSSKSRDITPQADRAFSNRLQLRSTIEKIPYAHHTEWREEKIIVTAEDLGWSNSDAELPFLQLEHTFRCRDAHHVHQHLLSIPVFCGHQHLRPMKVFEVKSNGQEQRVYGAPHTADKAWEMQDTLDDPTDVAVRIDTSSDSTVLSIGTGTASAHPVYMSLGVNTGFLKRENHGGLVVIAFLPKVERANKGNDEMFRIYKRKVLHRALEILWAPIRHLLSGRHLFQFADGHYRYIRVYFGPVSVDYLEACWLTSLVQGYVPCCVQEPLKLQEGPAAPRTSADAYEVRRAASQLRTITAQTKAAKEGGYHLGRANFARFPPQLLFTESVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NMW6</accession>
    <name>A0A2X0NMW6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C010g06121 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C010g06121</name>
        <name evidence="7" type="ORF">BQ5605_C010G06121</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NMW6"/>
    <dbReference type="STRING" id="796604.A0A2X0NMW6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006384">
        <property type="entry name" value="HAD_hydro_PyrdxlP_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016965">
        <property type="entry name" value="Pase_PHOSPHO-typ"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01489">
        <property type="entry name" value="DKMTPPase-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20889:SF12">
        <property type="entry name" value="LP01149P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20889">
        <property type="entry name" value="PHOSPHATASE, ORPHAN 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06888">
        <property type="entry name" value="Put_Phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031051">
        <property type="entry name" value="PyrdxlP_Pase_PHOSPHO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR031051-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR031051-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY14259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="253" mass="28911" checksum="E3DC48A04C83DB05" modified="2018-09-12" version="1">MAVKNQLVVFDFDWSFADQDTDRYVLEVLDPKLRVSLREHKKTVQWTDNVALHLRKLNEKGATKQQIIESLQGLPVHPAMLRGVQTAKARTDSKTRFLCLSNSNSVYINTILKHHNMENFFEEIITNPAEWKGNLLDLRRRVDPNGPQHGCKVGCSPNMCKEAEMALHATGAELDAYMARNGGWESYDRVVYVGDGGNDFCPLLRLRKGDVALVRMYRELSRRIVSEKETSPLQCTPVPWGGAWEVEKWLLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NSU8</accession>
    <name>A0A2X0NSU8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C016g08066 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C016g08066</name>
        <name evidence="8" type="ORF">BQ5605_C016G08066</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLPTM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY20469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NSU8"/>
    <dbReference type="STRING" id="796604.A0A2X0NSU8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008429">
        <property type="entry name" value="CLPTM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347">
        <property type="entry name" value="CLEFT LIP AND PALATE ASSOCIATED TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347:SF0">
        <property type="entry name" value="LIPID SCRAMBLASE CLPTM1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05602">
        <property type="entry name" value="CLPTM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="505"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="533"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY20469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="673" mass="74043" checksum="DD5B2D656BB3B878" modified="2018-09-12" version="1">MADSSTPAASGGGGAPGAGAGAVGAPAAGTRRREEARAAGFFDNPIVKSLAQAYMVYIVVNWGLRYLPGTSQHATANGIKPLVPPASGSAASLVPGGGARSNPVKVGDQGTVLSTTTKGAGFGAGGSLETLVAVWEEGSLLDVIARLSTSLDGEASPDGAVLPEVKWDGIPYAPGWETKVFEAEFEVPKSVQHNASLYLDVFVTRADAGVDQEQRLHVRKLLTRYMPLRKVRHAKKLIGSSKPTEEELAIEAIEVEREKNEVKPIVSYYHPNVTLELVTGSGNVAYTKLPDPLKVHVKKVGESKDEAGNGYMYPILWANDFWLMKEHMQPINESTSRLPIRIELKPISHFKWTIFATLEDSMAKSSQSAAPGTGDAFDGNPYMLIATIMCSILHMVFEFLAFTSDVKHWRSKKDLVGASVNTIITNVVVQLIILLYLMDHNEDTSNVILLTQGLGLAVEAWKITKAVDISVVPQTAGGVLPYKLLIKDKHVLSEEEKRTQEYDRLAFRIVGYATVPCLIAYTLYSLYYNEHKGWYSFCITTAVSFVYAFGFVQLVPQLIINYKLKSVAHLPMKSMAYKFFGTIIDDLAAFVVKQPLFHRLAVFRDDVVFLVLLYQMYIYRVDPTRANEYGQKLTEEEAKRLLEEKKKEEVEAAAKGEGVKEVKEVSAEERKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NU91</accession>
    <name>A0A2X0NU91_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C013g07257 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C013g07257</name>
        <name evidence="2" type="ORF">BQ5605_C013G07257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NU91"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY15129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="183" mass="20486" checksum="BEFA8064BF553E38" modified="2018-09-12" version="1">MSKALTIDQILARMSEREAKVESIMADHSARMDKWSQKVGPSKERDDDERVKRLADQKLIELIPFLKDNHPDAYYAFLNRNKDESEEDTSILETPTKAVKQIVEMIEHPAVLAGISNIAGEIPTDSAWRRQGYNTRETRGEKSHLDTILEAARANNPSPEDPDDDGSDDGSEKSNGNAGADHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NWA6</accession>
    <name>A0A2X0NWA6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C012g06791 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C012g06791</name>
        <name evidence="25" type="ORF">BQ5605_C012G06791</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="515"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="262"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="790"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="272"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGY16173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1408" mass="156720" checksum="03CD6D4629F1148B" modified="2018-09-12" version="1">MRLRYEPNELPAAQESGEIKIAKLGKDNYELWSIRVEAYLESKGYASVLEHGHVRPSDVSLAEWRTMHGLDASVTDTQVVVNLQKKDRSARALIIQCIDDANLKMVKSKTLSAKDIWDKLRQHHEGNAKPFKIRTLLMELSNAKYDEDENMGEFLKSMIDKADQLDDLGQKFGDEAMIAYILQALPPSYEMLKQAIRLGENRSVDHVINRLTDEYTERKLSGKFDKLLKNAGALAVQSTQASRDPNCVCRGCKGKGHFAMDPECPKYDAKKNHGRARNRNKKKKQDSKKSADSNELAEFVLTVKSLDESHSLQDNVANRVSQVNQGEIWILDTGASQHYVGDASLLSNRQSGNLKVQTASGQVVHCDTYGMVRFKLKSGASLSLANVYHLPGAPVNLISTRALFKSGAKCGWEDGKDVMTITYQGVILAKTLSGTGYALDFTRIVEDQAHVATRATVGAPLMEWHRRYGHVPVSSIMELVKSGAVEGLVLTDEKVHDCEPCISSKSRASKFSELATQVTDVLQRVFMDIGFVAEDQVDFQGRKAYLAIVDQYSTAKWTFPLKTKSAEEVTRVWIAFRQGVEKMTGRKIKRVRTDNGTEFTNKLIGADFQSQGILHETSAPYTPQQNGTVERFNGSLMAIVRAVLAASKLSWKYWSYALAYATFVANRILHAKLEGKTAYEVFYGKKPKVSHFCPFGSTVYAQVPKSKRSKLESTSVKGIFIGYDSEYNYRVLVDPDSDHKVIVTRDISVLEHKSEQVGVPEVTTLPVGPDEEKGPVDNDEIVVDELQDQVDGEQMPPARQNRPRWEYGDPAVKGRNPGRYEEIDANNEIPHRTRSQRRDAEQQVMYGSAMSVSLPPVPSNYEEAMASPEADKWIAAIKAELDAMARHQVLIDSDLPSGARALGSKWVFTRKENAQGEVTRYKARLVAQGFAQRPGIDYNETFAPVARPSTMLSLVGTAAAQGLFLEQFDFDSAFLNGTMTEMVYMKYPKGWDRPQTGQALRLVKSMYGTKQAPREWNAAVNSLMVERGYKRSDADSCLYVKRVDEKFIYITLYVDDGMVASNDQEFLDSEIEAFNKVYKLKRLGPVKLFLGLEFERTSDYIFVHQSKYIRDLVAMYGGGSVSKHPVKVPMEPRSDVEHSTDPFDDVALYQSAVGALQYAAHRARPDIVTSVRAAASKVSAPTQADWIAVKRIIRYLQGTVDWGLKFNHGGSTVFELYSDASWGDDMSTGKSIGAFVSILAGAAISWQSKQQSMVATSTTEAEILAASAAAKEAMWLRRLAADLELEQPKATLIWEDNQAVIAIALNPAHHGRTKHYNVHHFYIRERVTAGDIRIKYCKTGAMTADILTKPLARNLFELHREGMGMVGAGARVLCGGPAEAAGCLHEIASFWPSCFSLFSTTHSISHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NWQ6</accession>
    <name>A0A2X0NWQ6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C002g01614 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C002g01614</name>
        <name evidence="3" type="ORF">BQ5605_C002G01614</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY34338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NWQ6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF107">
        <property type="entry name" value="GLYCOSYL TRANSFERASE CAP10 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="2">
        <location>
            <begin position="257"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY34338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="519" mass="58413" checksum="0CE331374B26E246" modified="2018-09-12" version="1">MFHRVRRTITDQLSTLASSLPGSPAVGSKGSTDHEAEMTFAGATYRSLNNGGSVTGITAPTALTHGRSPIGLWGPWGALNTSPTPRSRLVQIWLFISPLTTILLVVAVLRMASREPPPEPVPRPVPLPETLNPYACAPKSNLTALSEICTLEQNKGKSWREAAEGYEAGHDRHLTQAQCDNVFPGLYLEIDRAVAYWKKEGGVTLKHLDEAEKKSQARVLIKNNRLYVKSYSDEQQGTRTKAVLASIRDAMIGSLEPLPDVEFVVQTGDTGMPAGAAWALGRREKEPQLTLMPDFGFFSLPEPGVGGMVEVADKCKQYEQRIKWADKVPKLFWKGAFMVDIRKELWDIARKYKWGAVSDLEWGDKSTIEKEVLAPEEHCAFKYLGHVEGFAYSGRGKQLLKCRSVFVTHRLKYIQHFHHLFNSDMNSPDQNIVLSPGHNFDELPATMQWLIENDDRAEQIADTSYNFFRHYLSPASVDCYWRRLLQQWAELMTFDPELPRDSASYESFILIGKTKWVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NY76</accession>
    <name>A0A2X0NY76_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Coatomer subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C017g08412</name>
        <name evidence="14" type="ORF">BQ5605_C017G08412</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Golgi apparatus membrane</location>
            <topology evidence="1 11">Peripheral membrane protein</topology>
            <orientation evidence="1 11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasmic vesicle</location>
            <location evidence="11">COPI-coated vesicle membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY19969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NY76"/>
    <dbReference type="STRING" id="796604.A0A2X0NY76"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051645">
        <property type="term" value="P:Golgi localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09254">
        <property type="entry name" value="AP_delta-COPI_MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14830">
        <property type="entry name" value="Delta_COP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000003">
        <property type="entry name" value="Coatomer subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027059">
        <property type="entry name" value="Coatomer_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121:SF0">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="13">
        <location>
            <begin position="370"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="245"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="346"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGY19969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="618" mass="67306" checksum="403D1F990FC9A55C" modified="2018-09-12" version="1">MSYRSTSSAFRSFSPHQSSQKGANRTPTRSIGSSSIWSSDVLAVVSSTCPHSNRRNGTMARAHPRPQLGSLIPKEPRLCTLTNGAPLLSRQFLGLPRSRLESLLASFPRLVSPTSEHTVLEASGVRFVYTPLEDLYVLLITNTQSNILLDLSTLSLVTRIATELGSGGRGGAIGEMDVMRVSFEILSAWDEVISLGWRENVSLQQVRSILEMESHEEKIQEIIARNKEHEAKEELKRRAKQLELQRREMTRRGQNPYSTNSSSGFTSQNNSYTPSAPSYDAPAPQRSYNEEHAPAPTTKPFKTKGMQLGAKGGKNNTGLAQALDGLDAEEPLLMQRHEEPQEQHYSSAPSPAPVAAPALTDVSPFEVPEQQDVHLVVRESLTLELNRDGGVDSLSLKGDLDLRIADPAKAVLVIALPPPSSYDKAIDLQFKTHPNVDKNAWAQRGEIKLKEGKKGFPVGQGLGVLKWRMTGTDESVIPISINCWPSSDNGICTVNLEYELENTSISLHNVLVSIALPPGSQPALSEAPSNGSYSLNPETSRLDWVIDEVSVAAGTTSGSLEFEVDGDDVDAFFPVVVDFVSQKGLSGVEILSVTNPADQSQVDFSIDSLLAVDKYEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NYI7</accession>
    <name>A0A2X0NYI7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BQ5605_C017g08522 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C017g08522</name>
        <name evidence="11" type="ORF">BQ5605_C017G08522</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY20199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NYI7"/>
    <dbReference type="STRING" id="796604.A0A2X0NYI7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10951">
        <property type="entry name" value="CE4_ClCDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF2">
        <property type="entry name" value="CHITIN DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016136900" evidence="9">
        <location>
            <begin position="33"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="10">
        <location>
            <begin position="65"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY20199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="285" mass="31326" checksum="7645B2269843485C" modified="2018-09-12" version="1">MCAVNRHNRMLFHCTLLSLASVALLSAPTALAESAANLEASSESLERRSAMAKVVTTCKNLTDRGEFAMTFDDGPYGWGSGIAKLFTKYNSNTTFFVNGNNYDCLYDEADDLIKRYKAGHTIASHTWGHTDVTKLTDAQLNKQLDLVETALKKILGIKPKLFRPPYGAINERAAKIIESRGYTIVTWDFDSNDSDGHTTGPQSIKLYNKLANSYPKPHIALNHEVYKSTGQTVVPQVVPMLIKKGYKLVTVDACLGINPYQSVGEASKRDKTWTCQGTPGPGKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NYX2</accession>
    <name>A0A2X0NYX2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C003g02466 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C003g02466</name>
        <name evidence="7" type="ORF">BQ5605_C003G02466</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY41074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NYX2"/>
    <dbReference type="STRING" id="796604.A0A2X0NYX2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015244">
        <property type="term" value="F:fluconazole transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF23">
        <property type="entry name" value="FLUCONAZOLE RESISTANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="546"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="578"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="604"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="56"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY41074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="647" mass="71230" checksum="D4E1A42D05A5EE10" modified="2018-09-12" version="1">MAPDIIRDSTIGQLFNRLTRGHFLPFADQRPHHVLPERYRAALDASTVRDPFDDNAAAASIDGSRSNRSVSSLQDIVEEEEEDSTGERDPDPPQVVLDFDTGRVSVEHPTSPPAPPVPRILISDIDIDKGNANEEAARPSPAPLVKNPFLVEFEDNDPDRPMNWSTGKKSFVASLVAFLTFSVYIGGPIFTPSIPGLLDNFDISPVVATLGLSLFVLAYGIGPMFLAPLQEMPRQGRTPVYIIGLLFFFIFQFPIVFAPNMATILVFRFASGFAGSPAIATGGACLHASARPVWSLKSETHTLCIVKGASMFDLFGPRHAPIAIGVWSIGALDLGVGQLRLTFSSALIISKGSFAAQAKGWTWPNWELMWISGFAFLVLSFLLPETLESTILIRRAERLRLRTGDSRFRTQAEIDAIAGENFVQLARSNLKRAFQLTAEPAVLFANSYIALVYACFYLWFEAFPIVYNETYRFSLGISGLPYLAFIVSGLITFGLYVLYVVYHFNPRMDRPGFVPEARLELGVVAGLFIPVSLLMFGWAGEEETHWIVPTIGAGLYLPGIFLIFQCILVYISSSYPPTLAASILAGNDLFRSSFASMFPLFGGYYFNALGLGVGCSVLSGLTFIMVPLLYLLIRTGPRLRARSKWIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NZE3</accession>
    <name>A0A2X0NZE3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C019g08872 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C019g08872</name>
        <name evidence="1" type="ORF">BQ5605_C019G08872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY22920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NZE3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY22920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="133" mass="15461" checksum="2917039E0E5107EE" modified="2018-09-12" version="1">MERANMMVAKMVQLSYDDALKLLKQHPDIEKLVLTQRRPKSVEKHVDFMQSLIEIIDKYGDGVLKFHWRWGENGFCTYFISFDVQELKLPGPPEKFLSAVTNSMTRDPPAKSVFKAHTPRKEDWKVGMYGDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P0K9</accession>
    <name>A0A2X0P0K9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BQ5605_C001g00671 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C001g00671</name>
        <name evidence="12" type="ORF">BQ5605_C001G00671</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin GLFG family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY48613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P0K9"/>
    <dbReference type="STRING" id="796604.A0A2X0P0K9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034398">
        <property type="term" value="P:telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2360:FF:000001">
        <property type="entry name" value="Nuclear pore complex protein Nup98-Nup96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1610.10:FF:000003">
        <property type="entry name" value="Nucleoporin SONB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1610.10">
        <property type="entry name" value="Peptidase S59, nucleoporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037665">
        <property type="entry name" value="Nucleoporin_S59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007230">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036903">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP98-NUP96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198">
        <property type="entry name" value="NUCLEOPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04096">
        <property type="entry name" value="Nucleoporin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82215">
        <property type="entry name" value="C-terminal autoproteolytic domain of nucleoporin nup98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51434">
        <property type="entry name" value="NUP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="8" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase S59" evidence="11">
        <location>
            <begin position="908"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="134"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="215"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="296"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="350"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="531"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="724"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="805"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="855"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="386"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="414"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="577"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="598"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="608"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="650"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="738"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY48613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1053" mass="105621" checksum="730AB5726B4228B7" modified="2018-09-12" version="1">MFGGTSSFGGFGQQQQNQQQQQSQQQQQQQPGGLFGNTAGTFGSAFGQPQQANGAFGQPAAATPSFGGGFGAGNTTTPAFGQAASTSAFGAQPTGGLFGTQATPAANTGFSFEMSAGGGSTGFGAPTTSAAPASGGLFGAPKPAPSTFGGFAAAGQQQQQQPAPGGGLFGSKSDRQEPHRLRTSRRKSPLTSSTLVDRAGAAGGFGQQVQIAPGSGTAAVQYQPTTVMEPPKEEGKPDPPNQTPHQFQSICCMPPYSNYSFEELRLQDYQANRKTPTASTSAPSFGGAFGQTTATPAFGAAPAQGGGLFGSTTPGFGAAQPATNAFGQSQSQQQSGVLFGTAGTSAFGQPAQQSGGLFGGATSQPAQTGGLFGSTSTAGTTGGLFGQPQQQQQQQQAQPSFGGFGQAAAKPANTGFSFGATSTAPASGGLFGQTQQQPQQAGGLFGQPQQQAGATGGLFGQPAQNAGATGGFNFGDMRRCVDASQCTSSAAKPLFGSAPTASSAPAFGTSTAASAPKPAFSFGAAPAAGGSLFGTPAQQQPATNAFGATPSSGGSLFGGGGSTFGQPAAPQQQQNTSSLFGSGSGSLFGAPKPAAPTTGGGLFGGGSSTTPSLFGASQPQQQQQFQQPQQQQPGSLFGSTMLGGSSGFGQSTAPQQSQQPTAYATADDVNAYGANPLFQGSASRTSAPAVEEKKKPIFTSFRGTPVNRSATKITRLRGFGGSSLVSKPAGNGSPLSFGSSVGPNGSGSPSVGATPGSPAGGRSSPLRLVNGIGDDAALSPNAFVTRQSFKKLVIAPKHLNGGLGTGSSAPAGFNGSVASKNGGTRPKVSFDPAVETSSRDRGQLAESISSAAHESTFAGFEATPSKTSGTNGGSSLADDSFAAQVSTTPTGWPPRRSPASAASTPTKVGAYYTVPSLDALKKLPAASLRAVPDLVVGRVGYGRVAFKAPVDLTTLPSLDDLLGSIVVFEDRNCSVYPNDYDDDKPEVGQGLNVPATITLEKCWPLDKATRNPIKDPKHPKLSQHIKRLRGLEGTRYIDFSPEDGVWKFAVESF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P105</accession>
    <name>A0A2X0P105_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C002g01088 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C002g01088</name>
        <name evidence="8" type="ORF">BQ5605_C002G01088</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY29841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P105"/>
    <dbReference type="STRING" id="796604.A0A2X0P105"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="509"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="533"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="570"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="7">
        <location>
            <begin position="644"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY29841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="765" mass="82054" checksum="8A3068A90424A2A0" modified="2018-09-12" version="1">MPQSGASTPRSTPSTTRANTFTQPNNGGTGHSTPTETTSLLDSEEGTVRASRRTYRGEGIGSGGGGGGGPVTFEGLDDEEDGSDYPTLHAGLSGREGGGGYGTSGGGSHGQGRTAAFATLPTKLARSASVARKVERRERRKTQWKVWSNRARYYVPVLAWLPDYSFKAFTGDVTAAFTMTSLIVPQSMSYSSNLVNSDPVSGLLGASIPPMIYSVLGTCRQLSVGPEAALSLIMGESISKIIDAETHAHGGMSNSAKMQLTFTITSVIVFQAGLITFALGMLRLGFIDAVLSRALLRGFITAVGIVIFVAQLIPILGLERYTKQGADTTPSKLMLMIEHVDKAHKLTLIVSCVALLVLVSAKSFKARLAKRRGYGFLAYVPEVLVVVILSTVFSATFDWQAKGLSVLGKVSIGDVRILLPSSSILARKYSSQCIGTASVLAILGFLDSIVGAKDSAAKFDYPISPNRELVAIGAANLVASFVSGALPGYGSITRSRLAGATGATTQMTSLLTGVFVLLVSFFLLGFLYALPKCILAVIICVVVFSILAEAPHDVMFFWRMRAWVDLSLMAMTFFLSLFISVEIGIIVSVAFSMLLCIKHSSAMRIKILGRVPGTSFYEPLEDDDDDGLFPSEEIPGILIVRFRDASLTFANAGALKERLRRLERYGQGRHHPSETPSRAEASVIIFHLVDVEDIDASALQLIYELVEAYVSRSVLVYWTQIQPIPLARLRKAGVLEMSGGEAHVQLNVQMALQVLEQSVISAQTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P174</accession>
    <name>A0A2X0P174_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C002g01188 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C002g01188</name>
        <name evidence="3" type="ORF">BQ5605_C002G01188</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY30862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P174"/>
    <dbReference type="STRING" id="796604.A0A2X0P174"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000808">
        <property type="entry name" value="Small GTP-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY30862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="303" mass="31630" checksum="5F4286C80A59AA58" modified="2018-09-12" version="1">MSAPDSASAAAEQPSRPVQVKLCLLGESAVGKSSVVLRFCSNSFEANKEPTIGAAFLTQRCRLEDKVIKFEIWDTAGQERFRSLSPMYYRNAQAAVVVYDVTKAASLEQAKTWVKELQRQANPNIVIALAGNKVDLVRPATEGDSSAAAAEDDDEADDATATPAEDANTDEGSSDGTAANSGVTGESRRQVPREEAEAYAQEAGLLFFETSAKTGEGVVEVFTEIGQSSGGVIPPRGSALADPIFFLRPSTAKKIPLEHLLASARGPGGAGPRGNGARAGAAGGPSVNLNETAEAQNKEPCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P1D5</accession>
    <name>A0A2X0P1D5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C006g03877 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C006g03877</name>
        <name evidence="6" type="ORF">BQ5605_C006G03877</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY54402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051132">
        <property type="entry name" value="3-5_Exonuclease_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620:SF109">
        <property type="entry name" value="3'-5' EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620">
        <property type="entry name" value="3-5 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="62"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="175"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1447"/>
            <end position="1525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1460"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1485"/>
            <end position="1502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY54402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1525" mass="168128" checksum="BE63C82382E97A48" modified="2018-09-12" version="1">MQLLSRFFRKRSADNADDKVVGTSATTASTACQNEIGPCVNTLHSVNTPSQARAAKRRFDELSIHNDGQDTGSTAIDQSTKKPRGQPRSLVPAPAATRPQGRPRKTEEEKEEAAIAKSERAAQQAAEIELDDERARQLKEAERARLEAERAPQRQLILDEQSQRMQTQTILNFAPATTSPQTPFPDGSSAIPSASDASVSTTPTSRSIPTSVGLALPDDSDSFDSDPRSNMSEAVIRSMATRKMMAVVPLELKFPSGDDQARKWVRRESLQQTLPPNNLKIFDPPFFYLDPLMLLGQPEDQPAGSGLVFLGRPRRACDLNNSCNKRYRSWSPEVLDQLSSSLHSMFPFHLSYRCAITSVVWNLMRGIFQFGLGLKQFANLLVTAHRAAHDRLEVDYRSAILAREADLPSTSLYPALGDWEDPTGNCGHVPNSQVLQEFYDSVMRKQETLLNHAESLKPCSIMTIDHSYKVPKQIAKVEGVPPFIALLMVGNEYGEVRAHVLTSTKGHSAFETSLEAMTKHLELYGNEAPTICYTHQPDTDGPFLRSKIPSLAPRVQSHSGSEYDILKLPPGITPTLVQSPYALTRLMKVMADTIPPEGKLVVGVDAEWATLPPGAGQQARQQPPRIAVDVLQFAWESLEGELFIHVIQLSLIIGKCAKGRLPDPLVLFLQRSDIVKVGVGVAGDLTRIANAIAHAEMWDVDEADEDPVAVAPALRHHGSLELVKHAASQGHSVKKGPGHRTLAGLCERFLLKHLPKNNNIRRSMQWADESLPQHFVDYAALDAYASLLGTRVAVMYESGWPIARGVIQSVDSSIDSSCQPPSSFHGFKWDKSRAIVAITQILTPGALVPEYNFHQDGSFTPQSLADLKATSNHRAAEDTIAVQESADSFSLVLELSALVVDLDDAPVPTEAQWTSNVSATHDSHHASEIFIQEKHSDAAVSATANESDRTDDVDAQIDDHDKDSEMVGPAEIAQALQLDCCKKTEAAGKAIWGKAATIKDVCISNYPLSLVPSSDDTAVQILIDLWHFFDRIYVSKKHGAAKAFARAFSDAVFIPNADDRLLMEARLAKLGMTWEEAIRSPVWNKKLWRCSKQPLFNKAAHKAAKRCLEAIRKGQVSDPVGIELYTDLGPCGGPDGKADDGVRLYSCQRGTNSLEGGIHRNLRQRFPKSGVSPCHANACLADCVLVHNLTVSPTSPSRFEEAATFLTHYPLHSQDLWLTVELHCLRRKTSAFLPRHSTTVSDIVNPLLYTPSTETFGIVPVQSPTAQMRFLIEPYHVERGTLRLEPVKWSPRNLLQNNTSAIQHMQSRLLTDRKLRHDWLAERQGTRFAVLHVHTPSERALYRYLSSKTRLGAPQNLRILEITELWNKYANGVYKMPEHINTWASRWSSLANAQATMNMGGNDVRVIQALLTDLSRGRDVSMLAAKPLLGHKPPVLGRLMEVEVDASDPPTSSIRPFVETASSDAGSSADLGTSRALTRAGTTKGARHRRFCGQTTCRRKGSKLSDDGSTRWIRTTHNHEGSVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-11-27" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P495</accession>
    <name>A0A2X0P495_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g02291 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g02291</name>
        <name evidence="2" type="ORF">BQ5605_C003G02291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P495"/>
    <dbReference type="STRING" id="796604.A0A2X0P495"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055100">
        <property type="entry name" value="GNAT_LYC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053013">
        <property type="entry name" value="LAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815">
        <property type="entry name" value="LYSINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22998">
        <property type="entry name" value="GNAT_LYC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LYC1 C-terminal" evidence="1">
        <location>
            <begin position="208"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY39898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="392" mass="44087" checksum="B65AE5B15AF59B73" modified="2018-09-12" version="1">MNSPASEGSILKRASRDQYLQTLENQLVEWGAGLTLEQFVEREKRLGETQQGHCLQCWVLAPSSSPDTLDFYCSVETFRRPILLLTEPGFPVRRCVTYSIASVFTPPHHRRKGHARTMMTLLHDQLRKNGTDGAIGSLLLQDTLSGPCGSSETPFHDAETSFLYSDVGEFYAKCGDPGWHIQGRTTVEYQIASLPKPISDSNSPFKPTFPAQPITRTQFDSLAQADSSLLQLELSHQSEASLIVEPTGSTYEWLTTRSIAAFHLGGVECASDPWGFEMGSSDDPETWSFVVFAFDAAPKKRIVNLLRVRCARREDYALLLSKVVEHVRRIWGEQGKIVGWNVEESWIEEAQKQGLKGTTCERDEHLAAMAVYAKGFENQSIRWLKNEQYSWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P5F2</accession>
    <name>A0A2X0P5F2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00285 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00285</name>
        <name evidence="2" type="ORF">BQ5605_C001G00285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY45444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P5F2"/>
    <dbReference type="STRING" id="796604.A0A2X0P5F2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY45444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="195" mass="20958" checksum="51BB9195DD73C05E" modified="2018-09-12" version="1">MDIDTPPRPLQASFPPEATASANPFGFGHNEPPRPLPEAPGVEFDAQTFDAKRALGLDAADDASGVADMSIEESAATTSKELSLLRASASSSTSISTSDGTSARRRKGRTANSRTSARKASGPRIEIDEGADEREADEDYRTASRWKAPTKSNFSFQVHHHHSQNLTNPQFDHPGIVPKTAGKWLDSNTPYVLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P627</accession>
    <name>A0A2X0P627_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C001g00426 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C001g00426</name>
        <name evidence="3" type="ORF">BQ5605_C001G00426</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY46393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P627"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015921292" evidence="2">
        <location>
            <begin position="22"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY46393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="128" mass="13960" checksum="063DB9A6F8CA5882" modified="2018-09-12" version="1">MRCSMSLCLSFLLFHTALAIAAPVPLRQVRDVGPSNELEQPNKTPSVDPKRAILSSSQLSASEDSPSASDDAENSQAKHHHSKLCKKKSMDTNGWSGGMNYSGMKKLRRRRVSVRALLGVKPPDSLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P879</accession>
    <name>A0A2X0P879_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">malate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C006g04052</name>
        <name evidence="14" type="ORF">BQ5605_C006G04052</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3"/>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY55612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P879"/>
    <dbReference type="STRING" id="796604.A0A2X0P879"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01337">
        <property type="entry name" value="MDH_glyoxysomal_mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000013">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000001">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010097">
        <property type="entry name" value="Malate_DH_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01772">
        <property type="entry name" value="MDH_euk_gproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF16">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="12">
        <location>
            <begin position="38"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="13">
        <location>
            <begin position="184"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="43"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="154"/>
            <end position="156"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGY55612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="377" mass="39838" checksum="A20218FDDC26514E" modified="2018-09-12" version="1">MLMSDDRCSGALLTLTTSTLLHQHQLQLLYFTNMPGLKVALLGAAGGIGQPLALLLKQNPAVTELALFDVVPVVKGVAADISHVDSPAVTTGYTKDDDGLKHALKDAQVVVIPAGVPRKPGMTRDDLFNINAGIVRDLATAIAEVCPQAFVCIISNPVNSTVPIAAEVFKNANVFDPKRVFGVTTLDVVRSSTMTAQAIGEPTHGPKYKIPVIGGHSGVTILPLLSQSEPALPSSLLNDQDKLSKLITRIQQGGDEVVQAKAGAGSATLSMAYAGYKFVERLIEAAFKGKKGVIEPTYVYVKDDAKLQKEIGTPLDFFAVRVELGPNGAEKLLPLGSMSEFEKGLMKAVTGELGGSITSELRVVLVVAEGVEFISKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P8B5</accession>
    <name>A0A2X0P8B5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C006g04092</name>
        <name evidence="13" type="ORF">BQ5605_C006G04092</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY55913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000007">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="12">
        <location>
            <begin position="1136"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="11">
        <location>
            <begin position="1448"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1474"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1490"/>
            <end position="1500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGY55913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1500" mass="168007" checksum="ADF9AC0EBAFD2172" modified="2018-09-12" version="1">MPTPTAPSHSPMYKPNDPPQLHSTSMEALRKYFMRLDFYNRRIARTPIMSDYNKIEGAGMGLQVFALKTWFTQGLSKHLAKPYTQFKSELIRRAVPADFVWTQLAELHRLRQASGHDIDAFQEFSDQMRSLQMEIGFQVVSDQEVAKLVLLGTDPELCRILRTHMVSSLAGWSDLLLEKLALDAPVVPTSPEAAEVFSDAHTDQPLEFDYQVFERIGREEWSVIAQRRQAIATQVGALQQRPTYSRPAAASAAPHVATAATGHSPITGGPCPVARLTVDERAYLDQNHGCYCCRTLNADHISRNCPRYLSPMGASATPSTPTSTAPAPRPRPRMVAAIRTFQETGDSTVFASLSSDSEDNNNPSCAPHPFPPLPVSLAGAHGTLLASALVDSGSPQTFLSEELVQRLGLERRALEQHSKYTLAMQNQVPTVFTCMHFVRVPLELANGLWAAGPTYAEVAPLGKDLAIILGGNFIYRHKMELGLFPQPHLTCKANPIHAIDLLALSSQLCAAARVAAIAPVSDNEEQLRLAALDHRLRAEFADRFPADIPPVHSYQSPVRHRIELDTPSTVVNLRGYPLPKKYREAWYLLLQEHLVAGRLRPSRSSYSSPSFIIPKKGCDVDPTIAPCWVNDYRELNKHTIKDRTPLPLPDDILSTCSNAQFWAKIDMTNSFFQTKMAEEDIHKTAVSTPWGLYEWTVMPMGLCNAPATHQRRVNEALQGLLGTICFVYLDDITIFADTLEEHEARVCQVLDALRRAELYCSPTKTNLATAECSFLGHIINHAGVHADPKKIQRIEDWSLPKTVKELRGFLGLVQYLRKFIPGLAEHTAALTPLTRQGLSSIATLWTPNEVRHFKAIKAIVTSLDCLRPPDHSANATPFWVTTDASNQGIGGVLLQGQEWKVACPIAYWSRQYIPAERNYPTHEQELLAIVEALKEWRIDLLGGHFHILTDHSTLEHFQTQRTVLSRQQARWLDTLAEFDYDLRYLPGKDNIVADAMSRYSFTNPLPTLVAAVSHVKLSDAVKQQILDAYKTDPFCQQAMSNIGSVTSDFKIVDALLYLRGRLIIPSLAPLRESILHNAHDAQGHLGDMKTYRTVQQAYFWPNMSRDVKHYVQQCDSCQRTKARTTRIAGKLHSLPVPTRPMADIAIDFVGPLPANKGFDRVLTITDRLSGYVRLLPARKADTAAEVAARFHEGWHRLFGLPQSIVSDRDKLFTSKFWTALHKRLNIKLQLSSAFHPETDGRSEKTNKTAFQILRALVNKEQSNWAECLTVCEYAINSSLNVATGKTPFELVLGYTPSLAPLACVDGDDDLPSVEELLARRFQACEDARDQLAISKVRQAAQSNKKHQDEPSWAVGDFVLLDSSDRQKRLHTRKRRAAKLMDPFDGPYRIVKAQPEISSYTLQLNGDDAAVPFFHTGKLKTSCKNNTALFPNREPARLGPVDVGGEPEYIMEDIVDERIRAGKQQYLVLWLSWPSDSNSWEPAEALEDTEALDRWERRNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P9K3</accession>
    <name>A0A2X0P9K3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C007g04593 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C007g04593</name>
        <name evidence="3" type="ORF">BQ5605_C007G04593</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY61726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P9K3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016110252" evidence="2">
        <location>
            <begin position="22"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY61726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="205" mass="23251" checksum="476068E790E2B631" modified="2018-09-12" version="1">MPSMRSLTSFAFSALVAVSSSAPTVSSMPSLIERHDSPLSPPSLPPPPSPSVKSSLPTFSPPPPTYENQTMCINYYFEHLPEYKDLYDCTVYDATKSFYDARYYQKKAIEKLEEEAQCAKDQADFADRVNQFAQAELAYAAEQKRFEWASKKFEHEKASLETSKKAFQALINQKVLEASQAMEIKHTCEKVFSEHTNEYIPKHSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PBS7</accession>
    <name>A0A2X0PBS7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C004g03015 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C004g03015</name>
        <name evidence="1" type="ORF">BQ5605_C004G03015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY69445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PBS7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY69445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="86" mass="9561" checksum="8A5DD03BC2569F32" modified="2018-09-12" version="1">MTKARRSIPLRGVAQAFNTIERASGRTPREVAYGMLCVSLVRPTRAIQERVEIVQRGCGELLRACVEGFWRAAGCCKVLMKDSGDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PC53</accession>
    <name>A0A2X0PC53_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C030g10750 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C030g10750</name>
        <name evidence="3" type="ORF">BQ5605_C030G10750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000069">
        <property type="protein sequence ID" value="SGZ07905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PC53"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retroviral polymerase SH3-like" evidence="2">
        <location>
            <begin position="58"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="198"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ07905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="449" mass="51132" checksum="DF82C8B8B38A4175" modified="2018-09-12" version="1">MLALLADAHLPKTFWEEAAAYFVYCKNLCQHLALDKETPNSVWQGERANALALHPFGCTAWLTVAPELRSKLDPKVVRVLFTGYDLASKAFRFYDTTTKKIILGRNASFLDTEFPGLHGDSTEQDADTHFASAPIAEPQNTVKTWTPLPVKSITSDPQTWREAMSSDKHEVWARAANDEFNSMRNDFNVFTIKDRSTVPMGATIVTSKFVWKTKRNALGEITGHKARLVAQGNWQRDGIDFNKTFAPVARFSSIRSLLALVATNGLHVHQVDIDKAYLHGDLDHDIWMTAPRGFDLPSDKVLRLRRSIYGLKQAGRIWNRHIEASLCDLGYTATGTDHCIYSWLDDCQRPHYIALYVDDLLMISPDLAEIKRVILGLEQRYGVKRLGPAEYILGIQIRRLDDGSIALSQERYIMDVERHEIALEPHWFRVQIERIKRCNSQAKKDYSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PDQ6</accession>
    <name>A0A2X0PDQ6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C020g09130 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C020g09130</name>
        <name evidence="2" type="ORF">BQ5605_C020G09130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000082">
        <property type="protein sequence ID" value="SGZ17566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PDQ6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040892">
        <property type="entry name" value="RPN1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17781">
        <property type="entry name" value="RPN1_RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RPN1 N-terminal" evidence="1">
        <location>
            <begin position="47"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ17566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="78" mass="8648" checksum="D1DCAAC825E59A2F" modified="2018-09-12" version="1">MQYTWIELPDHLICPRLAPKLWSAILPSTSMLDDVKKAVGITSADSSTASVSDKRLFADIFSVLAMTYSDSGKRETLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PEB7</accession>
    <name>A0A2X0PEB7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C008g05299 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C008g05299</name>
        <name evidence="7" type="ORF">BQ5605_C008G05299</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY80083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PEB7"/>
    <dbReference type="STRING" id="796604.A0A2X0PEB7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF13">
        <property type="entry name" value="THIAMINE TRANSPORTER THI9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="472"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY80083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="533" mass="57677" checksum="ED6A25424A2E5ADC" modified="2018-09-12" version="1">MAGFGSLYVVGGVRYLFSIGIYSLVPLVSSEVSLPFHFLTYLAFHSGGPLALWTTMLATVVFMTITAASLAEICSSLPLSGSIYAWAGAAAGPKYGRFFAFIVAYWSTTAWTSFVASNTQGTINYILTELTVFNHAFPGGLDATNIKFRAVQWICAEIFLLLAVLSNVLSPRKFTWVFKASAAIIAIDFFLTVIWLPIGVSKTYGFQPASFLMTTYNVNCACASMLFLTSGTGASSAWNYILAFLSSSGVLTGFDASGHIGEETKNASLANARGIFWSATFSGLLAFPLLILFLFCSPPLDTLFAIEAPQPFVLIYTLALGKGGQMVMTLVATVGLFVNTSLAILAASRLVFGIARDGVLPGSSWIGKVDRSGQPKNAIIFVGSIAAVLLCTILPSQVAFTSLISASGLPTIAAYALIPILRLLFTRHEFRTAKWSNGRFSELFCLITGIWNLFLITVLVSPYEWPVTAQNFNFSSVIFGAVTLLAILTWWFAPEERWLSHRDLLKIIDGTHQQQQTATVDDHASIPKKGLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PHQ1</accession>
    <name>A0A2X0PHQ1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C034g11306 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C034g11306</name>
        <name evidence="1" type="ORF">BQ5605_C034G11306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000065">
        <property type="protein sequence ID" value="SGY99819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PHQ1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY99819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="111" mass="12435" checksum="5A42CCD107097CF0" modified="2018-09-12" version="1">MFRDRLGFGIMLDVDVISCKSLKTTATNIDVRKFDCLLVAIALLAQHPSFADGVLAMEWTILKRLTHLSKTIKKNKAPHNKLVQLLTNVKALFRDRLGFGIMLDVAYTCAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PHT6</accession>
    <name>A0A2X0PHT6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyl-protein thioesterase 1</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Palmitoyl-protein hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C034g11346</name>
        <name evidence="11" type="ORF">BQ5605_C034G11346</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="FQNC01000065">
        <property type="protein sequence ID" value="SGZ00404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PHT6"/>
    <dbReference type="STRING" id="796604.A0A2X0PHT6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF17">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="10">
        <location>
            <begin position="22"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGZ00404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="245" mass="26129" checksum="5D9CFAE17ED38F88" modified="2018-09-12" version="1">MSAAGLRLRAFAPTVLAAPNPSAHTASLVFCHGFGATASDWQDLHRLPGLDHLKVILPQAPLRAISINSMQPMPAWFDILSMSHAARTQDGDEDEEGLGESVDDLTQIIQTEIDAGIAPGRIVIGGFSQGAALAMKLGLAGKLRLGGVVALSGYTPLQWKFMLSPWARETPVFVGHGTADSVISFSTGEAGVARLRGAGLQRLEFQTYPGMAHSACLEELQDLTRWLQKVVPSINRPEATGKPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PHW8</accession>
    <name>A0A2X0PHW8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-lysine N-methyltransferase EFM4</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Elongation factor methyltransferase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C033g11152</name>
        <name evidence="5" type="synonym">EFM4</name>
        <name evidence="7" type="ORF">BQ5605_C033G11152</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that mono- and dimethylates elongation factor 1-alpha at 'Lys-316'. May play a role in intracellular transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="FQNC01000066">
        <property type="protein sequence ID" value="SGZ01539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PHW8"/>
    <dbReference type="STRING" id="796604.A0A2X0PHW8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03188">
        <property type="entry name" value="Methyltr_EFM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026635">
        <property type="entry name" value="Efm4/METTL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843:SF5">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE METTL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Methyltransferase" evidence="6">
        <location>
            <begin position="107"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGZ01539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="275" mass="30367" checksum="86DD1364E2C225F6" modified="2018-09-12" version="1">MPGPSLQDAVSWLAAHADEAPALGAPLHPSKLGTKQHWDELITCFADQGEVWFGEDAADKMVEWIQEHVPQTDANLLDRQCSSRRKPARTKKLTDRASLFPYLWGAVGTGNGQLLFRLSEEGYTSLTGIDYSLSSIELAESILSSTTQHPKPSINFFVSDILSPDPDPRLTQKRWKVLLDKGTYDAICLSDQVDPKEGVRIGELYPKAVAGWLDEEAYLLITSCNWTRAELEKAFITPQTGLIFHSLVPRPSFSFGGSTGSSITTIAFQKKKTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PIS9</accession>
    <name>A0A2X0PIS9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C028g10488 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C028g10488</name>
        <name evidence="3" type="ORF">BQ5605_C028G10488</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000080">
        <property type="protein sequence ID" value="SGZ12204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PIS9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ12204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="168" mass="18600" checksum="BE26DB152801637B" modified="2018-09-12" version="1">MVPRGTRLFSTASSTLSAASKARRAIPLYLRPRASQSAPKPHPIHPSPSELPPPPPLNQDGSSKLLMSPKEKGKKREEGLEALGLKNWAEPPLVAQARAKTVKQRNVWESYLVLPPRTRLYISLGVFVFALIGLYGGDYLVPETEVERNTRIRKEELLQARQEAAAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PJ44</accession>
    <name>A0A2X0PJ44_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C029g10629 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C029g10629</name>
        <name evidence="2" type="ORF">BQ5605_C029G10629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ14939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PJ44"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ14939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="410" mass="45013" checksum="8BC0372140969ADC" modified="2018-09-12" version="1">MSQRKWTSLKRWAARRYYSELKMAAKLGISHARLVQAVKKFNRLASKGNVWSRFLSDPVIKVLNQQASKELDQSKAQSITKLAAQLWSFLRDQGDLGSAQLGEDDEELVRAAFAVAEAENNTTFTSIVPPTIITRSPSDIPSPTRMEQCKKYIAELQDLAQRMSKLYGVETLAFIVPRYQDVSPATKATVHSIGGLRFAAHCNDFKDPSGNSLLSNFASKMSWDETLKANEPADLKEAKTRSMDSATRGVLGKWHGTLFRAQLNSALETIHRRSDTGSSTGDFTPQKKMIWSTQGLKALDVKLRIKPGTKSRYEMALYHSAETSPKQTVAQLKAIIDDLRHGHLAIVPSVDPNDNTEAEASDDDSNGGEGPLSPRFGGAGDKGGEVRGGEKSGEEDRERNTEGVAEETGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PJX9</accession>
    <name>A0A2X0PJX9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C021g09296 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C021g09296</name>
        <name evidence="4" type="ORF">BQ5605_C021G09296</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000083">
        <property type="protein sequence ID" value="SGZ20742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PJX9"/>
    <dbReference type="STRING" id="796604.A0A2X0PJX9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ20742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="118" mass="12255" checksum="4A00B4D7AEB21047" modified="2018-09-12" version="1">MAPKKAAKPAGETATTSLGPNLKEGELCFGVAHIFASFNDTFVHVTDLSGKETIARVTGQLSYSVPRPQSASQPRAEAILALRACLPAEGAAEILSRAAASRYTTAPSKPAIRSSRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PK59</accession>
    <name>A0A2X0PK59_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">BQ5605_C029g10708 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">BQ5605_C029g10708</name>
        <name evidence="17" type="ORF">BQ5605_C029G10708</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ15881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PK59"/>
    <dbReference type="STRING" id="796604.A0A2X0PK59"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="16">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="SGZ15881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="497" mass="54348" checksum="EDEF1319C51EF10A" modified="2018-09-12" version="1">MEIENETGRRVKTLRSDNGGEYVSTAFNGFCVARGIRRKLTIPYTPEQNGRAERLNQSIVEGTLALLINSGLPRTCWDEAAMCYIHTKNLLPHAALKGGVPNCRWSGAPPTVGALRAFGCRAWATVPAHHRDKLNPKGIPLVFVGYNRHAKAWRLLDPSSMHVSLSRNVTFLKTEFPFVAVPARITPPSVPGFYPRPPPADAPAMPLPPVLVDPTQPPLLDDNATSLIHLPQRPPEPAPPEPTPLAKVKPTWEYGNVAKVGPDPGKYGEIDARNIIAGPRTCRQLVPTLITREDLVGGPDGPTPAFQGMLRAFASTKAGFAEQNFSVVQDPANWGDVIRLGQQDTWGGPAHNESDSLLNKYEVFEVIDSCELPAGEILLRLGWARLVAHGCAQRPGIDLKQNYAPVVKFTSIRALIALAAANGYHVHQADVNKVYLNGKLDKPLYMRVPQGIDMPGKILRLSKSIYGLRQAGTIVTNQQFEVRAQRHRAAYSALGTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PLG5</accession>
    <name>A0A2X0PLG5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C022g09586 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C022g09586</name>
        <name evidence="1" type="ORF">BQ5605_C022G09586</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ23095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PLG5"/>
    <dbReference type="STRING" id="796604.A0A2X0PLG5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ23095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="164" mass="18778" checksum="E434B39F8F83C91A" modified="2018-09-12" version="1">MGFPFRIRSRFSALGSGLLGIPRAPRFDGFRLVGAFRVEKVDFSSARGISRAPRFDGFRPVPPFRVEKESVPCGIWQLPIYTVDFSSARAIDRAPRFDGFWLVPPFRVEKVDFSSARAIDRALSIFIFTGNLGFYSKTYPRIGLCPTYDTYILHPWTWVHNLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LRJ3</accession>
    <name>A0A2X0LRJ3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C013g07255 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C013g07255</name>
        <name evidence="2" type="ORF">BQ5605_C013G07255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LRJ3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY15125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="209" mass="23102" checksum="6985743D1551021D" modified="2018-09-12" version="1">MPVSERLDSDQRFFDDLVEKSEAIISITNSSRSIGYCCAVCPRHKDRRLSLAQARAHFKTNVHKEQVRLQGIGVGDLSWVSSPDNDDLSFETNDSISSLGSDGSPSSGGTHHFDDSEQNYAQNDDDKGSDSDYGFEDTSAAYESLDDSESNREGDDVSGSEDDEGGTLTSAVIKQDLQSRGLLCTDYMVEYARVSIARLCYTYKRTPYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LS26</accession>
    <name>A0A2X0LS26_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C012g06825 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C012g06825</name>
        <name evidence="4" type="ORF">BQ5605_C012G06825</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LS26"/>
    <dbReference type="STRING" id="796604.A0A2X0LS26"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856">
        <property type="entry name" value="WD-REPEATCONTAINING PROTEIN WDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23410">
        <property type="entry name" value="Beta-prop_VPS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50960">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="187"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="233"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="526"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="569"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY16269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="604" mass="63003" checksum="6CA5D1C644778F77" modified="2018-09-12" version="1">MNVHGGTITYEATYAVPAPTSTRGVSTKLGASADGKQISYGSGRSAIVRSLDPGGPTLSLGHAAPVTVTKIISPYYAASGDASGALKVWDTTGNYSLKLEAKPISRINDIAFDGEGKRLVVVGEGRSSWGATFSLDTGSSIGEVAGHSKVINSVAMRPQRPFRAVTGSDDFSVVLMNGVPFKFTSQSRRHQRFVQSMDYAPDGKLFFSAGSDGRVFLYDGTTGEDKGELVDGQAAHASGVYAGAFSRDSKQIATSSADAQVKLWDVETSKVVKAWDFASSGNSLQQQQVGNVWAGSSIVSLSFSGNLNVLDPRSDTPISTLYGHQNPTTAVIADPQSSSTFFSGDSTGRVLRVEASGRTEPLENAHSGLVVDFVEDGKGTIYSTGYDDTIKTLSGGTEFDSKMLPTAGQPKGLAVSTSDGTLYVATSIEVQVIVGGSKTSSTPVASTCIAASSDGAYIAVGTEQSTVVLYSSKDKSCLQLLSTIELRASASSLAFSPDSTHLAVGLSTGKIPLYEVASHKLVHSRWADSTARIHALAFNQSGTHLVAASLDESIRVYSLKNPSIVLASKNAHRGGVSGVVWNGEEGLVSSGADGAVKKWGVEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LTK8</accession>
    <name>A0A2X0LTK8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C014g07455 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C014g07455</name>
        <name evidence="1" type="ORF">BQ5605_C014G07455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY18739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LTK8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY18739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="76" mass="8250" checksum="65D41326B8D24902" modified="2018-09-12" version="1">MPQADRFRVSHRTFPSDHRRTRISLCQTAGTTALCPTPYACQAVLLLTAVLVGHADLLGYLATQTILITQRASVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LTQ2</accession>
    <name>A0A2X0LTQ2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C011g06582 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C011g06582</name>
        <name evidence="2" type="ORF">BQ5605_C011G06582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LTQ2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY12696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="657" mass="72444" checksum="70FD242B866FB639" modified="2018-09-12" version="1">MASSSSSSRIVKAERTPPSSSLAKRIDTPSEVASAEAEREEEMNNDEQEERLDQEEDAQAAMEEERVRVATPSAPAQASESPIAIAIAIAIPALAQAPPAQPLPVGPAPSSIVPIAFISTNPHWRPPPRVDCALCKGGAVPTLVDSWDFLRTRWHKVRFHRTSSSRSTSLSPRLIVLWAVFQTCSKHHKPSKAEYTPFQDLLDRLETQVEHKTDLIDLEAAFLVPELASIQNVHLIPDLRNLLKPLSTMFISDISLSSRWHFVFKDAIPTSHGLKFRYTCSQTSRNDRPRDGKKARKTDHKREGGRVEKFACGGMVSLMFDMTNREVVVHLVHKVWHVVYEKMRVVELDVLGWVRELMGESDTDESMMKKIEERAWEEGMEGGVKSTNYQIRRYMGIVVEERRKEANGKGKTKATTPALEDENEHEPGPGPGPSTRKRGRRSPPPVDPVLLALSASQTPEPVATPPRPQKKVRTRRKTQPAHASNSKSRDAQTSTPNLDLNVEKNIPTLPVPPLDQTLLDVEVPSNEAISPPTNTTADASINAAMAIILGTNHQSQATMEDIQVVPHTPQPLSSGQPNPSTHPLNNPTDLPVSTPSTSATASTNLVRQGFQADWSNQQGALEALSAEDQDMMIRLHQANVDATLKAAAREVRETSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LTU1</accession>
    <name>A0A2X0LTU1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C011g06550 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C011g06550</name>
        <name evidence="1" type="ORF">BQ5605_C011G06550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LTU1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY12592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="203" mass="22877" checksum="A774E9387A90CB02" modified="2018-09-12" version="1">MKAYYITDSKFDAAKLKDILAGHHLKPQGDFESSQKQLFDHQCTKLCLFRGADVIEAGLQTDSIQFLTEGEVAEVVQKAKDEHGLERARARALRHMHIQEKPGTTAKQSQRRPHPVTLNSRKNFHTCVDTGADLCSVAPYIPRQLGARIHMYDQVQTFRLGTKGSQSKVNFYCILETAFAGVKKPQRFEVANVYYNVIIVGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LUB6</accession>
    <name>A0A2X0LUB6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BQ5605_C010g05969 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C010g05969</name>
        <name evidence="12" type="ORF">BQ5605_C010G05969</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LUB6"/>
    <dbReference type="STRING" id="796604.A0A2X0LUB6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF31">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="36"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="143"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="256"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY13766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="350" mass="37583" checksum="CA773B43807807B6" modified="2018-09-12" version="1">MEAEGDVFEHAPAKSALKDVAYGSVSDSSAHPLRLALWLIHAVVPQAAGIVSKLFEHPFDLVKVRLQSQPFDQPLKFNGPWDCMIKTFKKEGLLGLWRGVSMPVGGAMAENATLFVVYNQTQAFLRRLSPPSAPLDPSAAPVLNFSHLAISAAAAGACASFVLTPVELVKCKMQVQGSLQPSSVPQGGPVSIFRSILKVDGIRGLWLGQTGTLIRETGGSVAWFSTFEFCSSQLIERRHRAGQVSKTGVRVTKADLSALELMASGAAAGVSYNCVLFPADCIKSTIQVEDEMKGARKLGEKRRSFVQVGKDIYRARGIKGLYQGCGLTALRAAPSSALIFYMLVVLGFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LUH9</accession>
    <name>A0A2X0LUH9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C013g07180 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C013g07180</name>
        <name evidence="1" type="ORF">BQ5605_C013G07180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY14960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LUH9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY14960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="54" mass="5923" checksum="996293D3A832AAAD" modified="2018-09-12" version="1">MGSMSLARACVMPTLEVSHSPQVPLVAGHSWKERRAVEEVCAAYARVQEGLNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LV12</accession>
    <name>A0A2X0LV12_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C017g08557 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C017g08557</name>
        <name evidence="1" type="ORF">BQ5605_C017G08557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY20261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LV12"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY20261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="129" mass="14722" checksum="60DF3E7F46F7D677" modified="2018-09-12" version="1">MNGPGREQWCVAYARELSNHEGMQWAPGTRRESGPPVGRRAIPTKVVLLKKRNDRGEVLTFKARLVARGDLQKPGDYRTTYAPTACIASVRIFERSNAFHRLRRSIYGLKQAGHDWNQTLHDQLRKSHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LV17</accession>
    <name>A0A2X0LV17_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C010g06087 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C010g06087</name>
        <name evidence="8" type="ORF">BQ5605_C010G06087</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LV17"/>
    <dbReference type="STRING" id="796604.A0A2X0LV17"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11318">
        <property type="entry name" value="AmyAc_bac_fung_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013776">
        <property type="entry name" value="A-amylase_thermo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015237">
        <property type="entry name" value="Alpha-amylase_C_pro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006969">
        <property type="entry name" value="PRK09441.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43447">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09154">
        <property type="entry name" value="Alpha-amy_C_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001021">
        <property type="entry name" value="Alph-amls_thrmst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="7">
        <location>
            <begin position="36"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY14170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="549" mass="62372" checksum="73A25CE83CB2219E" modified="2018-09-12" version="1">MSAQEEAKKLEQKYRTANYKANARGLGREQEEHRNYTMMQGFEWYSKGGGKFWNDFKQKSKSLADMGITAAWLPPPTKGQSPEDNGYGVYDIYDLGEFDTKGGKATKWGTKEEYIDCIKTCKKNGIVVYIGQSSTGSRLSPSVKTDLTRTFCKLLSDAVLNHKAGADEAEPFMATEVDENNRNQDVSGAYEIEGWTKFDFPGRGDKYSDLKWRHHHFTGVDWDNRAEKKAIFKIQGEGKGWALAVDGEKGSFDYLMFADIDHSHPEAREDIKKWGTWIIKETGAEGIRFDAVKHIDEGFISEFVQHIRKELDNPDLFCVGEFWKDDIGSLTGYLDRFGDQFSLFDTALHYNFKEASTRGGDYDLRAIWDGTVVKDHPMDAVTLVDNHDTQPQQALESWIDPTFKPLAYALILFRGDGYPCVFAGDLFGCSSEPFVEPMSQLDDFVRIRKCFTYGPTRDYWDHPHCVGWVREGDADHDGCAVVICNGSEEGKKRMQIPDGHAGEKWTDVLGWYQGEVTIGDDGWAEFSCHERSVSVWAKVDAKHREEFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LVS4</accession>
    <name>A0A2X0LVS4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C013g07361 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C013g07361</name>
        <name evidence="1" type="ORF">BQ5605_C013G07361</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LVS4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY15411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="40" mass="4471" checksum="E32E208515781AB1" modified="2018-09-12" version="1">MTRLDQHRLVLGVGRPVIETWLENAGVNDDELTRLAAVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LWC9</accession>
    <name>A0A2X0LWC9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">tRNA(m1A58)-methyltransferase subunit TRM6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C012g06874</name>
        <name evidence="8" type="ORF">BQ5605_C012G06874</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRM6/GCD10 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LWC9"/>
    <dbReference type="STRING" id="796604.A0A2X0LWC9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017423">
        <property type="entry name" value="TRM6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945:SF0">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT TRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04189">
        <property type="entry name" value="Gcd10p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="466"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="469"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="479"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY16448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="522" mass="57469" checksum="889220733B8E8636" modified="2018-09-12" version="1">MDTVIASPPRDPPSTSISILEATASTSTSAPRHASNDDAPAPVLPRHVIREGDNVLLRLPSTVVKTVKVTPSGTISLGKYGSFKASHLVGLPYGPTYEILDDGSLKIVPRQVVAEIEETEANNQEITATGAQSLTYDDINAFRSEGLSGRVSRAKCIHVARYEFSRLTHSKFGVLLQQIIEKQIQQHANFDKKTEYSKDKYMKRKEAKYLRLFTPIEPTVHNICEYNFEKQSAKIRELRPDTLSNMMNMANVRPGARLLVVEDVHGMVVSACVERMGGQGRLIIINDFDSPPDIHITESFNFPPSALEPIGSLHWGMTEPSWVPADLPLEISQAVLEKTKNSRDIAKIKRRKAAFELMENTRKDFFAGGFDGVILATPYEPLGVLDRLLPYIAGSAPIVIYSPHQATLSEAYQSLRTSPHFLSPTLSEPWLRKYQVLPGRCHPEMNGLGHGGFLLTTTRVFDNPEANSHKVKVGKKRKVENGDGDGERKGEGLKKGKLEGDGKGDGEEAAADPPLEGMGEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LX25</accession>
    <name>A0A2X0LX25_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C015g07878 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C015g07878</name>
        <name evidence="3" type="ORF">BQ5605_C015G07878</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LX25"/>
    <dbReference type="STRING" id="796604.A0A2X0LX25"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23524:SF1">
        <property type="entry name" value="MRH DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23524">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="409"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="473"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="509"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="542"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY17755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="575" mass="60220" checksum="C2DC29A1A011F111" modified="2018-09-12" version="1">MAGLTTASLVGLYEPEPEPETELDHGVFADHRPSSSMLRSAASSSRLTAYLGLDRSVRPINAVALASSTLLSITLLVFLNASQPFLLDLLDVPNAGRMTGQLVLADELVALGCYSVWGFISDRIGVRWVAVAGHALCGVALVAYVNVPLSVLIIARMLFAVGASALVTALSAALSSMTALPESESESECESDIGTGQDGDVRTSSPHGHSQPRSSNQRELSNEHSRLLATSSEQATTSAANKSARFAGLLGFSSGLGALLAVFVLLPLPAQISARFANVSLRAALRYTYYLTAALAFVESLFLIVGLNRPSTVAPIKSRERQANSTLRDKSIATLKEMSLGVRIARQEPRIALGYLTSFTSRASATIVTGFIPLLINHYFVSNGLCSTPSSALDVPTPSNPPFEVCRRALILASILTGVVQLVSLLCSPLVGFLASSLSFTLLLALTSTLGTVAFIGWSFLPHHGDPRGPMPIVYAILAGISQIGGIVISLALVAQARGTLVQKQGKEVAGVIAAAYSVSGGLGILLVGTSAGWLFDAWKGAPFAIVAVVNGVTAVGALIVWRGENRGRASVRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LXE7</accession>
    <name>A0A2X0LXE7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C015g07737 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C015g07737</name>
        <name evidence="1" type="ORF">BQ5605_C015G07737</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LXE7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY17297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="303" mass="34401" checksum="A15683D0B3F67873" modified="2018-09-12" version="1">MSEPLRERTGCIQRTTLTKLESVLRTGNRFVRQFAWVKVRACWNTAKENASAYHQTEADAPTTFLHRGRKTLFSWCPVIDILMVGTSTESLARSIRLRCLSNIHYFPCRRRWLQPQHSLVRVQSNWVTLRRKTATMRMKTMRRRAKTMVMVNDDGQVKGAEVESLEFTILCVLLAQTRRVLLNPALHPTSLPGVLDRQKLPSRHRSAKILSFHQERLRLTTGQGVTGLTPNQIGRSVILGTTLHWGRTTKHATVRISLHEGLKPSPATSNAQAVSAMNGESFNRCTSYCVLYLHSDHVSGQFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-03-27" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LXI8</accession>
    <name>A0A2X0LXI8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C015g08009 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C015g08009</name>
        <name evidence="3" type="ORF">BQ5605_C015G08009</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EMC8/EMC9 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY18214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LXI8"/>
    <dbReference type="STRING" id="796604.A0A2X0LXI8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08060">
        <property type="entry name" value="MPN_UPF0172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005366">
        <property type="entry name" value="EMC8/9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12941">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12941:SF10">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 8_9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03665">
        <property type="entry name" value="UPF0172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="2">
        <location>
            <begin position="20"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY18214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="218" mass="23213" checksum="55AF2F4EE06E8F38" modified="2018-09-12" version="1">MAPSTVTSSAGSSTSTPTSYTLSPLAYLKLVLHASKYTSCSVCGLLVGSTSSSSSSALTTITDIIPLLHQWTTLSPMMEAALQMADLHLQSKRTETTFVGLYLANSRLSDLSIPPTLQLVADKLRSRFPSAVVLVVDNEHLDSTTQLPLLAHTYSPSSKSYTPLPPSSSSSSLILSDPSILSTTLTRVQQGDSTLIGDFDDHLADPSVDWLTNPRVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LXK2</accession>
    <name>A0A2X0LXK2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">2-oxoglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">1.2.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">2-oxoglutarate dehydrogenase complex component E1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">BQ5605_C014g07443</name>
        <name evidence="19" type="ORF">BQ5605_C014G07443</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 2-oxoglutarate + H(+) = N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:12188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:20092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="1.2.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.2" evidence="5"/>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY18687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LXK2"/>
    <dbReference type="STRING" id="796604.A0A2X0LXK2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02016">
        <property type="entry name" value="TPP_E1_OGDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1150:FF:000002">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11610:FF:000009">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12470:FF:000003">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000002">
        <property type="entry name" value="2-oxoglutarate dehydrogenase, E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="entry name" value="Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1150">
        <property type="entry name" value="TPP helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032106">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="ODO-1/KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006914">
        <property type="entry name" value="PRK09404.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008907">
        <property type="entry name" value="PRK12270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF4">
        <property type="entry name" value="2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16078">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="18">
        <location>
            <begin position="658"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="SGY18687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1049" mass="117686" checksum="93BC7F0F87189652" modified="2018-09-12" version="1">MLSTGRRLLTCRLPTWNNIYATSIARGVVRDHTAAFSTTRGPHATATPSDTAKAPSPVDQFANGNNAYYAEEMLRCWRQDPSSVHPSWATYFSGLDSGLRSEDAFRPPPGLVSLPSTDGNAPFSLAGGNGSGLVEDHMKVQLLVRAFQVRGHHIANLDPLGINQPDLSSTMPPELTIENYGWTEKDLDMEFELGAGILPRFKEQGVEKMSLRKIIDACKQIYSGSIGIQYIHIPNRDECDWIRERIEIPEPWKYTVDEKRMILDRLIWSDSFERFIASKYPNEKRFGLEGAESMIPGMKALIDRSVELGVQSIVIGMPHRGRLNVLANVIRKPTEAILAEFAPSLDPTQEAAADVKYHLGANYVRPTPSGKKVSLSLVANPSHLEAEDGVVLGKTKGIQHFEGQGDLSSAMGLLLHGDAAFAGQGIVYETMGFHDLPYYGTGGTIHLIVNNQIGFTTNPAQGRSTPYPSDIAKSIDAPIFHVNGDDPEAVTFVCQLAADFRAMFKKDVVIDLICYRRHGHNEGDQPMFTQPKMYQVIKDKPTTLDVYTQALVEESTFTNEETEKHKSWVWGMLEKSFEASKEYKPTSKEWLSSSWDGFPSPRELKENVLEARPTGVEFDVLRKVGKIISTYPKDFEVHRNLARILKTRGTSVEDGKGIDYSTAEALAFGTLALEKTHVRVSGQDVERGTFSQRHAVLHEQNTDALYMPLAHLSEDQATVTVCNSSLSEFGVLGFELGYSLVDPALLVIWEAQFGDFANGAQIMIDQFIASGEKKWLQRSGLVMSLPHGYDGQGPEHSSARIERFLQLCDDHPFYYPTSEKQARQHQDCNMQLVYPTIPVYMLSAHRLKVSNIFHALRRQIHRDYRKPLIVFFSKNLLRHPQARSSLEEMGPDTHFQRYIPEPEPEGFGAAEDVQRHILCSGQVYYALLAEREKRGLQAIVAISRVEQLSPLPYDLITPHLDRYPNAVQYWVQEEPINGGAWQYMQPRLETAMRETAHHASKRIYVAGREPVSSVATGSKKQHFYEIEQFMEQAFDLSKHAQSHGSQKAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LYL9</accession>
    <name>A0A2X0LYL9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C017g08415 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C017g08415</name>
        <name evidence="1" type="ORF">BQ5605_C017G08415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY19975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LYL9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY19975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="75" mass="8626" checksum="D296C7893ED5A94D" modified="2018-09-12" version="1">MPNQPNQFVSGDHVVQQGYNGLYNNPQHSDLKDVRWGKLATLASTSEVYYSIFCWNVHHFRMRPPQILPVPLISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZH9</accession>
    <name>A0A2X0LZH9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">BQ5605_C002g01706 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C002g01706</name>
        <name evidence="13" type="ORF">BQ5605_C002G01706</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Tom70 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY34948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LZH9"/>
    <dbReference type="STRING" id="796604.A0A2X0LZH9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 10" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="409"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="443"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="511"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="47"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGY34948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="706" mass="77495" checksum="E296F6A5F7A5FA7B" modified="2018-09-12" version="1">MATSTTTTTTSGGGGSPAASLTNLFNTHRRAVLVTLAVAIGATGAYYYSSSAPSSGRGRAGSGGRGSASSSSSSNKNGGEGSGSGSGDEAAKKRKKKSKKPKTRTATPTTADESTSNTPSSQIGIPSPQGEGGEQDPSEADIEIMDPEQRTKLALTLKAKGNKLYSGKKYREAIACYSRAIACEEQAVFYSNRAACYTNLNEQENVIEDCTSALRLDPSYIKALNRRATAHESIGGIDHLYQALCDFTAAAIIDNFSTESTQVSVERVMKKLAGEKATIALKDREPRLPSPTFIKAYLEAFRPRESSANLSAPAVHALIFSWCTEPDPEDPEDPSQGDQTLKLAFEALHAKDFVHALSYFNEAIEQGISTNEGKAAALNMRATFRFIMSDAPAALVDLDEATSLSPTGTQSWVKKASVHMELGQPEEAFRDFDRASAIDPENADVHYHRGQVYFITGEFDKAITEYRRSSEIDPSFIFSHIQLAVANYKNEAVEKAMHQFRKFLKDYPKSPEVFNYYGELLLDQQKYEEAVQNFEKSIQLDKNSIPRNALYVTSLSWTVQLHLLTNEHALYLELNRPLVNKALAVFQWKQDFAQAEKICREALEIGKSPLAFRLARHDRLTQDLYPIVVDEQCDVAVATLAQLLLQQNKVHDAVKMFELSAQVSRTEPELINALTYECATRAQIAFIEAYPSYAEKLGLNRSAPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZV7</accession>
    <name>A0A2X0LZV7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C003g01828 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C003g01828</name>
        <name evidence="3" type="ORF">BQ5605_C003G01828</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY37500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LZV7"/>
    <dbReference type="STRING" id="796604.A0A2X0LZV7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056808">
        <property type="entry name" value="HTH_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168:SF1">
        <property type="entry name" value="ORC1-LIKE AAA ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24913">
        <property type="entry name" value="WHD_AAA_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA protein C-terminal winged helix" evidence="2">
        <location>
            <begin position="348"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY37500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="569" mass="65415" checksum="6DC8DB658B098FD7" modified="2018-09-12" version="1">MERVGPVDWRVPLRREQVGIILLAVAGLCYHKWYKWEAYRKMRRAFAKGYDPVLALASAAVYDEQGGLVPGRVVRKEQEYIQKIVNGEISGEYLLLMGPKGVGKTSMIVDAMVNNQADGCAMMEAHEDAEVFRLRLGKALDFEYNEDSFAGLFSRKDPREAGPCLDIERALAKLEKVRRWQLRVEVVKRVDDWVRGIMLQVAISFRKDRGRPMVLVFNNIHFVHDDPEGHALLHMLQQRAESWAQAGVCTVIFSSDDFHVYRHLKKNASRMHVLSIRDLTPLETHTFLRGTHEKAFPEDGEVGWNESWRIWDLIGGRLSYLNRVARRKDMLEAAEEMIEQEKEWLHHRLGLIPDHDDDVMDEQKVSSCSMLLFQHFAKMAEEAEPLLNRNTINSVVPSLGTEEALEGKVMKEEEETLGQQLEDDLVNSLTPEMDPFVSYREARVIMTRPDYLIDHDRHNIVNINSHHQVRPDSRMMLTVFRRIAKEEGFDQDLQDVRDRVDQIESLHRTAELTVKKDDADLGGFLRLRVGEYRKEHDKPDADSDGGESGVGEVGARTPKVDEEEDARLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M1H8</accession>
    <name>A0A2X0M1H8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C003g02385 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C003g02385</name>
        <name evidence="3" type="ORF">BQ5605_C003G02385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY40488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M1H8"/>
    <dbReference type="STRING" id="796604.A0A2X0M1H8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022158">
        <property type="entry name" value="Inositol_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF7">
        <property type="entry name" value="SACI DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G15890)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12456">
        <property type="entry name" value="hSac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="2">
        <location>
            <begin position="322"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="910"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="921"/>
            <end position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY40488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1039" mass="113094" checksum="AE8676286D79394E" modified="2018-09-12" version="1">MHRPAQLPLSATVSPFAHRLHRRLVVHAHEDGLILQPIAPSPTTKSIVVDRADTNSNAGVRIPWAKRAQPVAANDLDRGTEEDGIVVEGVAGIVHGFQGSHIILIVSSTVSATLWDEKRSKIHSVDQLVSIPLSDYQAANTALTRHAVKQFAQKARRAAAAAASSSTATTSASTSDNGAGTSSEDEDEDGDDDDGETDDGGETTDVDADARPDTPIKQPKKSPFWERLTPKRMPKISLSAIKPKAAIPAPANPTADSGNPTPPSSSDTAESASSSPDPNKPDELTQDKEVVALAEASTSAVSDRDNAETVRSQIELDAKIVAETMRTLRGMAFSYDIDITRSHQRKYEASLVVAGLPSPTHGKSGPSGMIGLVEPSSHLPLWRRADRRFFWNAHIMSTFIDAGLHAFILVLQQGFVAHSSASVPLQPYTTLASPSNSEGPSHVELDMVLISRRSIERPGLRYQRRGVNPLGQVANAVETEFLVGAVRDSKQHVASFVQTRGSIPVYWSQSPWALKPAPVLDRTEEDRNAALVKHFESQNKLYGKVVVVNLAEAAGKEGVVVEAFRKGVELTQSEDKVKYVYFDFHHETKGMKYENIGKLITQVQPDLEDMQCFWTTDQGTDQVFSTQQGVVRTNCIDCLDRTNVVQSAIARFVLNRHLVHLGIAQEELATHDGLDTAFNTMFADNGDAISREYAGTSALKGDFVRTGRRNWLGAVNDASNSVARLLQSTVTDFFRQATLDFVLGVNPNAFQEFSERLDTSDPGQLLRLAKIREEAIETSTKYCLSPGEERLGGWSMLSPVEPNTLRSSAGKYEEKIVLITTKPGTKGALYIVSYEFTLQKVTSFLRIALEDISSIRTGAYILSALDATTRDPEENYGLVVHYPEASVIERVRTYTLKSLRLKARTSSTASLSSARTDEAGPSSPLAVSPSPLSPISPNETGPSSKIAFIALKALRRDVIKTDDGYASSRIFKLSRTDGRGATTAKSIVDDIVSILRDESGHGGKEGWIEEVDIVSLSEAKSHTTIAERLSRGVQRLIWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M1K6</accession>
    <name>A0A2X0M1K6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g02415 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g02415</name>
        <name evidence="2" type="ORF">BQ5605_C003G02415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY40725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M1K6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY40725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="65" mass="7246" checksum="96D7C4BC15A5EC7C" modified="2018-09-12" version="1">MIANHSHSVAKLLRAKTEASPRRTPIEPPRHPCLRTTLHAFQRSLCHSSPPHLNTLLPSDLPLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M302</accession>
    <name>A0A2X0M302_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C001g00333 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C001g00333</name>
        <name evidence="6" type="ORF">BQ5605_C001G00333</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TBCB family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY45751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M302"/>
    <dbReference type="STRING" id="796604.A0A2X0M302"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF85">
        <property type="entry name" value="TUBULIN-FOLDING COFACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14560">
        <property type="entry name" value="Ubiquitin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="5">
        <location>
            <begin position="181"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY45751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="240" mass="26659" checksum="C7A95AE7978C56A8" modified="2018-09-12" version="1">MHLPELVLDFRGKKDKLERVSGISSSVQVLSLQRTATGTGHSGQVPQGQTVVAQLNEDHKTLAQYGVQEWMTIRVDNSDAHGKTQSSLFTDTSLVEKFELTNQKYEARSDTVLAFKRRHQLGRFAPTADSSHELAASQRMQLPDNLVPGARCEVALSDVLSRRGTVRFLGPTQFGPQDETVWVGIEWDEPVGRNDGSVDGVKYFETKPLRASFVRPDKVTVGNFPEVDPFADDDLEGEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M333</accession>
    <name>A0A2X0M333_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C002g01390 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C002g01390</name>
        <name evidence="8" type="ORF">BQ5605_C002G01390</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY32634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M333"/>
    <dbReference type="STRING" id="796604.A0A2X0M333"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07308">
        <property type="entry name" value="lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051136">
        <property type="entry name" value="Intracellular_Lectin-GPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005052">
        <property type="entry name" value="Lectin_leg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223:SF45">
        <property type="entry name" value="RE50040P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223">
        <property type="entry name" value="VESICULAR MANNOSE-BINDING LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03388">
        <property type="entry name" value="Lectin_leg-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51328">
        <property type="entry name" value="L_LECTIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="L-type lectin-like" evidence="7">
        <location>
            <begin position="94"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY32634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="402" mass="44321" checksum="D14480B67B7FD850" modified="2018-09-12" version="1">MVSSSTSRNTGRRPRRVRLPRARTGLLRLLLVAVVLSAFVFVAVEGKGQGKTGKKAAAKAKAAAAAAAAAGGTIAANTAKSGPPKSKRGNTEKTVPLRTHSLYAPYVDSDLQNRWFDFGGSTIINTNKHVRLTQDRASQAGWLWSRLALAPNSFEVEFEFRVDGKSSTLYGDGFAMWFTKARAGTGPAFGSADYWEGLGIFFDTYANSRHSYSFPRIYAIKNDGTKAYEVGKDGQSQEIGGCSVSGKRKGVIPRWLQLVVADDDTEHQLDFRRTDVTAKGRFTYFRGKFTELAIQHDKWDQWTTCFVLDGFELPANPFLGFSALTGDVSDAHDIISITTSNIAYHPPSVENSNRPPGLRGIPGKAFLSFIGRLLKWFVFLAMIAAAWIGYKNWKKTKNHKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M3N0</accession>
    <name>A0A2X0M3N0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C002g01721 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C002g01721</name>
        <name evidence="1" type="ORF">BQ5605_C002G01721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY35053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M3N0"/>
    <dbReference type="STRING" id="796604.A0A2X0M3N0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY35053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="521" mass="57006" checksum="15032223F8D9B7CD" modified="2018-09-12" version="1">MRKYDSTSIMAHVSAALNVAMKLAELAAEHQSSCARAMERPVDDLIEARGRIQAMEEATLGGEDWKPILPLLKPVAVAPAVVVVTSVVPLSAVPRAAACNNYNRWRVCITNLSPLSCRAVTSASRPRIASSASVLWFRGRIPHRSRFLTSAPYDLNRFLWPFLRSLPLRHRVACLRSLVQGSNPHRSRFLTSAADVLDSNLRFSLPGRIPHRSRFLTSAASVLWFRGRIPHRSRFLTSAITELPVHGVGRASLEPVAAGSKEDVPFVPSMPAPGPSPAPETSARMRIMAREVDSFHDAMYKIVPPLDAPAFKANIKALEKVAHVAPYLAAIPKQIRKGFDFGIKDPPSERHIAKNAPLTEEQQLVMDGEMERMLDLGYIAGPYDKDELEAAVGPFRTNPISCVPTSVAPGMPPKWRQIEKLSYPKTLGGRVGHWGVETLYRERGAEGGSFSTSFEALLIPSKLALASDACMHGLGIAINGYSAYFALPEGWTDLPPPRHSVSITNAEAWAVEALAETALRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M3Y6</accession>
    <name>A0A2X0M3Y6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C001g00633 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C001g00633</name>
        <name evidence="7" type="ORF">BQ5605_C001G00633</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY48246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M3Y6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003840">
        <property type="entry name" value="DNA_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02689">
        <property type="entry name" value="Herpes_Helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="6">
        <location>
            <begin position="108"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication helicase" evidence="5">
        <location>
            <begin position="203"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY48246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="345" mass="38009" checksum="4BF9F4185198E344" modified="2018-09-12" version="1">MLCTTKLIIWDEAPMAHRFAVEAVDRLLRLINFVYPGLRTVNKESLEDLIQLFSCQAILAPHSATVDHINAKLLEEFNGDYIEYRSADEVVEAGETGGGMAPELISPEYLHSINPSNFPAHHLRLKEGIPVVLLRNLDPDAGLCNGTRLIVSHARLRVIQAIILTGDRAGTTVFIPRVRLETNATGSCQLGFTMRRLQFPLRVALALTINKAQGQSLDRVGVDLSLHPVFTHGQLYVALSRAMSVDRIKVLLPSRDPANDDDDLQVVDRAAAAATATVTNQQSEYSYKNNYINPASRPVILAIACCLRLSNLNPDSDPKPSIPLCSQSNEWGIVLKLSFVLFPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M4J2</accession>
    <name>A0A2X0M4J2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g02204 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g02204</name>
        <name evidence="2" type="ORF">BQ5605_C003G02204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M4J2"/>
    <dbReference type="STRING" id="796604.A0A2X0M4J2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015016">
        <property type="entry name" value="SF3b_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038737">
        <property type="entry name" value="SF3b_su1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12097">
        <property type="entry name" value="SPLICING FACTOR 3B, SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08920">
        <property type="entry name" value="SF3b1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Splicing factor 3B subunit 1" evidence="1">
        <location>
            <begin position="64"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY39345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="173" mass="19259" checksum="7E0735C5486D4576" modified="2018-09-12" version="1">MKPPRQVWRVVPPPGPKTGVPRTLPILLPSIRSGFRRLVPPPSLAILLQLLSYSFNHLIDVQTAGYAPIRTPARKLQEAPMAMNGGGFIMQEDAASASMLGITQELPTEIAGVRDLQFFKQEDATYFAKILGDQDESELSIEELKERKIMRLLLKIKNGTPPMRKTALRQASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M5G3</accession>
    <name>A0A2X0M5G3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C003g02353 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C003g02353</name>
        <name evidence="4" type="ORF">BQ5605_C003G02353</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY40319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0M5G3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635:SF196">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="392"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="873"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="332"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY40319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1560" mass="172229" checksum="E21EFE498E574929" modified="2018-09-12" version="1">MDNNNNTNNASHAAIPPLRPDPPDPPGQAPATTTKSYSAAVGARSAAKHGNATANASTAVAAHPLMHNIENCVIINTPPSTSVEQVLLALDKYYPGLTGAMPCVIKGQRGLRFPKAADLDTLVANGLTVGKTLCKVEKLYSSTRGGVVQCTLTGFFSDPEGLCLFDEQIAAYGTVLRRRIQYIGKTKHISGVYEFILALKDVDVLPPASLSIARDGVTERIPLRITGGMCHCVFLEQDLAAQTEDLSNRAQPDSLSKNARPEFSFNFPCKTATPPAPQPASNQGIAYSLVEKSSESPSSETTSPSPSPPPATPKSIITRSKSIAALSKPATREAPPTAPALEASEPSPEPSSPTPLPSAAPKARPDDADTDDEADEEAEDQEAPPKDSINEDRKRASLFSNLRSHNADVFLLSETGRPSPERVAQWTQECQDLKLSALFTPFNNTAILWKCDSVAITFDPESPPNTLRASFSFPDRVTDATFCVGDSKVRVVSIYAPSSDKPDKKRFLSHLSTALRQVVRDEPSPPALLVGGDWNCVESQPLDSENQNGTNYGGQEMRDLATANNLFDAYRLHHPKGRATTNRSAPGTCRRLDRIYVSPDWVDLFHDHKIWAPVLKSTHSMVVARFQVPGAIDIGPGKFKLGLHVIEGDATCEYLTSIVRTLYNKALLQTPNDPPAAWTSTKHRLLPELQALARTFARFRRGGSEQERADHSRYGAALRSRLDPSLAGPSSIFIRLRKVRASDLIPSLTVNDVVHSDPDSMLGAAGDYFERVYEDRPIDDAVLKAIIDGLASTRLSPADSLKLEEAYPLEEMTKAQAACKSNSSPGPDGLPVEFYRATWPATGPILRDVINSIPTEARQPGPLPRNTAHIHLIHKRGERDQLSNKRPISLINADERIISQAHNQRLAPLLESLIGPTQRGFVPNRWIGTNIAEVQCLMDPGLPGSTPVSGMLAVMDFEKAYDRLSHPYLDAVLCAVGLGPKARQWYRATYTNQSASIFLNGWLSATFDILSGVRQGDPLAPSLFVLAIEGFACQIRLRVKGIDIAGLQNVRELLFAGDACCALHNLSDLDHLNRAIELYERASASKLSNVKYFFYPLGAFRDRSIAPDLGTWRLSDSQFRYLGIQVGVEIAEDAGWEDVKASTIARIRSIPMYDLPYAAKCSIINIYCYTKILYYSRFLPAPKSVVKEIEEAAMLAIHGRASDGTQRRPKVSRSRLCTPLDHGGFGLIDLPRRLAIDHAKWVFQLRAPDGCFTRHLFDIRIRLQAPNEPTPFTLSRPAPNQHRCPWIWIWWACFCHPPPKWDHAVRKTTKLLPARWVRYFEAWALVTTLNSPELSKSQNLEQWATHVLYFPAGHGIKLSVNPTLFRGPDGEVMTPSSFVNASKRHQVFIFPPIFPKGHQKVFDLPEQRWNAWWKALRKVRRVHSDAEDTGHLLSLGSLHPGSQVASPTSPHPNNRSTSCVMCLSEAPECLVHLAVGCPFARRLWSALSPTPHPVFVDFVCPVVSRSERRLVELRVLFFHSIWKLCRRRRFSSDLLEPITETEFEGLRASIQESKGRLVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M630</accession>
    <name>A0A2X0M630_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C001g00189 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C001g00189</name>
        <name evidence="4" type="ORF">BQ5605_C001G00189</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY44678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M630"/>
    <dbReference type="STRING" id="796604.A0A2X0M630"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041545">
        <property type="entry name" value="DUF5601"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF25">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18151">
        <property type="entry name" value="DUF5601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="3">
        <location>
            <begin position="490"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="956"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="709"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="824"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="851"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="881"/>
            <end position="906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY44678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="998" mass="108418" checksum="12ABC710224D8170" modified="2018-09-12" version="1">MLSSSTTDVHDAPSTPAQDGGTLRSMDAVRHALPPLDQDPSRHEHEHVRGHHPSTSTETIPNPWAEIGSTTVSAVKPYLADLDPLQPQSQHPSSSSNAVVPPSTSATSTSSTSTPLAPLAPLARPPPRSSASYGAEIQTLGHYVAPGSKLELMSDDSEEEDDSPTMASSPTRRPFSTSETTSKPSTSADPSLSNAPSTPQGRPAPTPGSSRFFGGMLRSFSGSGSAPGSASGSSPGSVHTSPTSQTHYSKRQEINDEKAALQQRDSDAGHAVRSRSESTTPVPNTTSVSGLSSSSSTTAPPLPLPPHQQQQQHRLAMSKPLASIASVFRSSPSNFRPSSSSGLAPPPPPPSEMSSKKREKAPEAAPTTSLPEPQFDFNKFLEQMRSRSADPIAKYLRSFLKEFSRKPPVATNDQIRVINDFLDFIANKMKGVDPWRKLFVEFEPERADMEFDLAVEAMEKLVMNRVWHLTFTPAIDLSALPGEMSPTGDIERDHVLSQRIRLFAWVKPSHLDLPLPDPEDVSPSVSRTNSPLPPVDLLADDDQQPLTESSTTGGTNSAPTSEDPILSAAEIRERNRQAQAFLDFSRRELCKINSYKAPRDKLICLLNCCKILFGLIRQVSKDQGADSFIPFLIYVVLKSNPEHLVSNIQYIQRFRNPDKLTGEGGYYLSSLNGAISFIEHMDASSLSNMTQAEFERNIERAVLSFPTDRDELPVAQRRSSSTASPMPRSREVSSQPARSPLPPPNPIRLPLPHQSDEPTHQSNIDVESASVLPGPSPTNALESTRNFLVRSSDSVERIVSKPLGAIGRILDQLEQVASSGASGIAGGTAYQHPLPPPPFHHHHQQQQQPQSEFYHTSMPQQAPPQGWLQGPYQNPAGPGAQTLSSPVSRTRSLSPSPSIRSTTNSVRRYPRSRGSSTGAPRGMGPQQGFVDPGLFARSDQTTEEVTREIDRQFEEQRLAALETLRNVFPDVEQEVLEVVLLSHNNDVGKTIDALLEMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M7D0</accession>
    <name>A0A2X0M7D0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C007g04540 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C007g04540</name>
        <name evidence="2" type="ORF">BQ5605_C007G04540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY61252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M7D0"/>
    <dbReference type="STRING" id="796604.A0A2X0M7D0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016002906" evidence="1">
        <location>
            <begin position="22"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY61252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="207" mass="22978" checksum="30B94851E9FD89ED" modified="2018-09-12" version="1">MIHVHLPALLLLGGLFAFVGASSGSASNEPVQQVRFMREQAYGPMYMAVNQGLELRSNGILKDDLGRLATLLGDGHCLNHGLNKYRRCPLTFRCDGSGQDGYLYDINGYPVPFFFPASWRYFGPDVGWQPPARFSCKANWVLPSQWLDSAHLATWWTSGPPTAWKAPPGFACPSFWTCSACERTSSSAHIGLDSQKYRVRMTPSLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M8T2</accession>
    <name>A0A2X0M8T2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C004g02763 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C004g02763</name>
        <name evidence="1" type="ORF">BQ5605_C004G02763</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY67292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M8T2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY67292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="86" mass="9762" checksum="96C4FA495E5FAB85" modified="2018-09-12" version="1">MKLAEVGIIAAVPGLQNPFGPELSDTTRNHFSDILVPSPSACGRGQRRPPLFDPRGERYEIALEPHWFRVQTERIKRCNSQAKKDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M9R9</accession>
    <name>A0A2X0M9R9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C006g03973 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C006g03973</name>
        <name evidence="5" type="ORF">BQ5605_C006G03973</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY55128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M9R9"/>
    <dbReference type="STRING" id="796604.A0A2X0M9R9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="263"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="277"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY55128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="380" mass="41011" checksum="5F2E90BD613BCBA9" modified="2018-09-12" version="1">MDSFPASPSAPRDPSSPESSIGEQIATLQAQLTALQASQPAAAATPAVTATASKVVFPKHARLDGPKSFTNWLRQLRLALPNQVRVYVLDGVIPPTWTADQLAARDDAAREIIVGSIDSADVSATLDAIPSDDLSAPRIFAALKARFAPDDATRTLELFARLWDFRKMPASLNDVLATHVLAMVPSCLDSFRLTFTDEQRNRRDLPKLTTLTDRIRIQLRSAGLSTSHSAMLATTSSCPACRAPGHRLRDCTSRAKHPPTGPCRRCHKKGHWAFDCKNRGEQTRSSDDTQDDTSSSAAPQPNSIRAPRHMVADRSLFTTYCQTAHTKIGGIAGGITAIGMGDVAFVAKTGHPITLRGVLHTPGLHVNLLSVSRLCDTDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-05-29" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MAV7</accession>
    <name>A0A2X0MAV7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MICOS complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g04344</name>
        <name evidence="2" type="ORF">BQ5605_C006G04344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY58143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MAV7"/>
    <dbReference type="STRING" id="796604.A0A2X0MAV7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044284">
        <property type="term" value="C:mitochondrial crista junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019166">
        <property type="entry name" value="MIC26/MIC27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033181">
        <property type="entry name" value="Mic26_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28268">
        <property type="entry name" value="MICOS SUBUNIT MIC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28268:SF1">
        <property type="entry name" value="MICOS SUBUNIT MIC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09769">
        <property type="entry name" value="ApoO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY58143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="200" mass="22018" checksum="0D727EFB39F060AE" modified="2018-09-12" version="1">MASILPRLTTRLAIAGGTSSFLLQRQTIHAEDKDPELAPAAASRPATQMAIYNKVPVPLTLLPAHLPLQDEVAQARRWLQTSYAQLHAQVRKGARTWIKWEGKGEAQMESMIAPDETLVPGGLYVAIATLTGSILARKRNFMLRLALPGMFFGGALAYFLPGAAAVVQSNFERLEESYAPSLYRAHQDIKYHLQSPDSNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MBP1</accession>
    <name>A0A2X0MBP1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Replication factor C subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C007g04624</name>
        <name evidence="13" type="ORF">BQ5605_C007G04624</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the activator 1 large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY61925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MBP1"/>
    <dbReference type="STRING" id="796604.A0A2X0MBP1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17752">
        <property type="entry name" value="BRCT_RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000021">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000005">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000001">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000395">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013725">
        <property type="entry name" value="DNA_replication_fac_RFC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012178">
        <property type="entry name" value="RFC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF6">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25361">
        <property type="entry name" value="AAA_lid_RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08519">
        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036578">
        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="12">
        <location>
            <begin position="173"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="820"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="820"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="856"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR036578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGY61925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="867" mass="94965" checksum="29CD7520FA851445" modified="2018-09-12" version="1">MSAKKGKVAASITLSSDSDDGTKAIIPSKTTTKMGAVIATSSSKRSTPAKKTSASATKKKRDDDGDYAMDEDEDEEEYKPSTSSLKKKGTNGAATGSSSKRKSIVPTTDDDSDDDDDVKGKGKAKAKPPPVQKKAKVEDHDNEDKVEAKPKPKWSYKPRAGPSAPGSKDVPVGAENCLAGLTFVFTGELDSLSREQGQELVKRYGGRVTSAPSSKTSFVVLGQDAGPKKLEMIKKHKLKTLNEDTFLELIGKRPSGAADPKFKEQQKKEEAKVQDMVKEMSKKKDGPSQKPYSELLNQLWTVKYAPTKLSEVCGNKSTVEKLSKWLEAWPKSLKSDFKKPGPDAMGVFRAVLISGPPGVGKTTSAHLVAKQFGYDILELNASDVRSKKLLESAFKSKTSDTTISGFFKKDDGSQQGDNLGINKKSIIIMDEVDGMSAGDRGGVGALNALIRKTKVPIIAICNDNKSPKMKPLATTCFQMSFRRPTPPEIRSRIMSIAFKEQLKIPVNAVDQLIAGSQSDIRQVVNMLSTWKLSQRATMDFDDSKKLAKMNEKNMIQTPWTLYGKLFSPGSFAPNSAMSLNEKLEVYFHDHSIMPLFVQENYLRGNFTSASRYSGKEQQLKKLELVCNAADALSDSDLIDRMIHGSEQHWSLMPTHGMFSCVRPAFYCHGGGGYPMFPAWLGKNSAQRKMRRLLGDVQIHMRLRVSGDRREIRQSYIPTLFQQIVTPILERGAEAVPSVIETLDDYYLTKEDWDSIVELGVGDHASEPLLKKIPAAAKAAFTRNYNTSDHPVPFYKNSVGKPAMKIANAGPAPDLEEALLDDEVVDSDEAEQGDDSGSEMDITKDKMIKNKAAGANKKGKGSAATKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MC47</accession>
    <name>A0A2X0MC47_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C013g07084 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C013g07084</name>
        <name evidence="10" type="ORF">BQ5605_C013G07084</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY14751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MC47"/>
    <dbReference type="STRING" id="796604.A0A2X0MC47"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43302">
        <property type="entry name" value="TRANSPORTER ARSB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43302:SF5">
        <property type="entry name" value="TRANSPORTER ARSB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016039772" evidence="8">
        <location>
            <begin position="23"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Citrate transporter-like" evidence="9">
        <location>
            <begin position="70"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY14751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="482" mass="51920" checksum="87134B401B7F396B" modified="2018-09-12" version="1">MASDLTTSWCSLSLFFTWLVHFDRFQNSKAYISTALDSTGGLRALAFFISQKSARTPQLSPPSAEKTASGVQLYTTLYVFWFVAGVIVGNDPIVLSGTAFLGYMTRVTGITTPTAWTFSQFIAANIASAALVSSNPTNVLIAGAFELNFLTGYTKNTLLPSVITQVDTTCTAAVVAYPLLLVTFKTLKPPRKDGTSGVPAYIPAQLTPPDVDPRSALLDPKGAVFHSALILVTLVVLVGTSFVKSVEVWMVTAPGGIIALLRDLWTERGSHPLSTPQEPEGINLGRVIVSTSRYEPRYSLPAFDRAFRRQFPTTATTISRLPLSLLPFAGGIFVLARALTSLGWTSIFALWLAKISINPAVTIFFLGYFIALVLCPLCGTNIGATILLVEILRDPNFSHAPHIVASPKILTGAIFSTALASNLGAFSWTFSSSLAGLLWVSILKQKGIHVKAREFAAWNCLFLPILSTVASAVVLLEVECFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MC88</accession>
    <name>A0A2X0MC88_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C007g04844 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C007g04844</name>
        <name evidence="1" type="ORF">BQ5605_C007G04844</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY63892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MC88"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY63892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="82" mass="9579" checksum="13C152DCF6AF7425" modified="2018-09-12" version="1">MHKLRSLDIAHVKVRVWTSLCSHVVVSAGDPHRAFTEVSYKKWSQLTLRDRDFRKRLGRETAWLGVSEERCNPRLDDFLSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MCS2</accession>
    <name>A0A2X0MCS2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C008g05366 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C008g05366</name>
        <name evidence="1" type="ORF">BQ5605_C008G05366</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY80354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MCS2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY80354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="78" mass="8444" checksum="D7214386D5874C4B" modified="2018-09-12" version="1">MEAIDLVYLGIQKILILQVVGRWELGQRLVQVNHIELVIFCQQCHHSGAVGVAGSPVEDGVCPHEAAQATLNVVDGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MD09</accession>
    <name>A0A2X0MD09_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">beta-glucosidase</fullName>
            <ecNumber evidence="3 7">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C004g03079</name>
        <name evidence="9" type="ORF">BQ5605_C004G03079</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3 7"/>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY69927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MD09"/>
    <dbReference type="STRING" id="796604.A0A2X0MD09"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000495">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF10">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA14" evidence="8">
        <location>
            <begin position="428"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY69927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="894" mass="96758" checksum="EFE510A351B8C5C6" modified="2018-09-12" version="1">MARNYTQLDVDTTLAKLSVTEKTNLLAGKDFWHLNEVQRHGIPSVRVSDGPNGVRGTKFFNGVKANCFPCSTGLGASFDKPLAKKVGAALGHEAHAKGAHVLLGPTCNMQRSPLGGRGFESFAEDPHLSGMLTANYVEGVQSTGVAACVKHFVANDQEVCSLLFNATPKRCTHVLGEYITQFERFSSDSVVGARALREIYLEPFRLAVKHAHPLTFMSSYNRINGIHVSESKDLLDDILRKEWGFDGLVMSDWTGTYSTDAAVKAGLDLEMPGPTTMRGAAIGRMLAAGKLTVSDIDARVRNVLELVNHAIASGIPFNGSESLIDTPESRALLREAANSAHVLLKNSDSLLPLKHAKKIAVIGANAKVPVASGGGSASLASTYTVSPLEGITSAAKEIGAKVEFANGCSTFRYLPLLDPLMKNGKLEAWKDDFLDDWYQSKFDDAKAPEPDYQCNIDTSMGILVDDRSVYAKLGATPRTRISCTYTPETSGPYLIDLCTLGFGSVLIDGLVVLDNVKTRKSGEIFFGGGSEEESATIQLEKGREYLIELRHSNNLTSAEAGPFSAMPQAIGFRLGLYPDQPEEVARQEAVELAKASDVAIVVVGTNKDWESEGFDRKTIALPGAQDALVQAVQAANPKTIIVTQSGCPVSMPWIEQASTVLQAFFGGNELGNALADIVFGKVNPSGKSPVQEAEQQAFDWNSQGQTGGQPFVRFVRDYFVYARGSALHRTSIASSPPPPQGIYMGYRHYDANNIVTLFPFGFGLSYTTFSLSSLSRTPLSSQAECTFSMKVRNTGSVPGRSVVQVYVRAVGGARGVDRPKKELIGFTKTSLLQPGEEEVVKVEVTKEAFSYWDEKKGSWSVEEGEYEFLVGENSGELKLGEKVEVKEAFDWRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MDF5</accession>
    <name>A0A2X0MDF5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C005g03241 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C005g03241</name>
        <name evidence="9" type="ORF">BQ5605_C005G03241</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY72946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MDF5"/>
    <dbReference type="STRING" id="796604.A0A2X0MDF5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031508">
        <property type="term" value="P:pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF15">
        <property type="entry name" value="NAD-DEPENDENT HISTONE DEACETYLASE HST4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="8">
        <location>
            <begin position="40"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="168"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="356"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="485"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="440"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="218"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="372"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="496"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="520"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="536"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY72946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="629" mass="67750" checksum="27EC8B7B28B14FEB" modified="2018-09-12" version="1">MSSITPLSIMSFGASAGADPTSQGLALPPFASRIVEPVNDDPASLSMQHIARTVLKAKRVVVVCGAGISCASGIPDFRSSEGLFDSLKRQHPEARLNTGKDLFDASLFSSEQNASIFYTMIAELKSMADVAQPTAFHSFLKALDDEGKLMRVYTQNIDGLEEKAGLSYGLGDKSLPLPPRRATARSLGKTSSSLSFSLSANPHPSKQSNPSAAYPSPAASPPADEVPPPPTHSKIPRCIPLHGHLGTMSCAHCSTTVPINPFMPALAQGTAPTCPSCESIDLARTVAGDRSRGVGRLRPDVVLYGEEHRDGERVGEITHRDLIGARPDLLLVVGTTLKVPGTKRLVRELSKVTKPPVYDAEDDEEMEMPVASGSSTSSNSSGTTSSKTKRPKPAPVHVVYLNYEFPKPSTEWKDVFDVWLRGDIQAFVQAVHDEKDEGIRREMVRQKEKELRELKALERARARVEQEVALANVEAAEIKKKKISDKAKVALSQASKTERKPKPRAEAGLKATKAKSSPEPTAVPVVVPPKKTRTTGSTAKPRTTKTNKPMTPLPTPPSSQAAPAPTRQTARVAKQNVPVESMLSPLKTRSGTVRNTAPINKLPFAVTKLSYTQVTSGPSFKSTRTNTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MF24</accession>
    <name>A0A2X0MF24_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C037g11566 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C037g11566</name>
        <name evidence="1" type="ORF">BQ5605_C037G11566</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000062">
        <property type="protein sequence ID" value="SGY93004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MF24"/>
    <dbReference type="STRING" id="796604.A0A2X0MF24"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY93004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="121" mass="13503" checksum="90635B5C9A8022BB" modified="2018-09-12" version="1">MEATQDKRNVFTKNRTEANNTVVDVCGVRTASYTGMSPVFERHRVGSRGWTRHVDACSATPFLFNLKTKVMINYDDASSAGEKTKYALSQGLKGVYTFDPTGFNEGVLKTIRKKLDATAEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MFH4</accession>
    <name>A0A2X0MFH4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C005g03649 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C005g03649</name>
        <name evidence="10" type="ORF">BQ5605_C005G03649</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MFH4"/>
    <dbReference type="STRING" id="796604.A0A2X0MFH4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050794">
        <property type="entry name" value="CPA2_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32468">
        <property type="entry name" value="CATION/H + ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32468:SF0">
        <property type="entry name" value="K(+)_H(+) ANTIPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="9">
        <location>
            <begin position="82"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="547"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY77482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="952" mass="100956" checksum="FBB38E675EE49859" modified="2018-09-12" version="1">MSHATDHVVTAKLTCHATRSSPVLSAVTGLAGATLSTVLAEPSATAAKAVAASIFDPSHPNPVEFDSTNPLILFIVQAFIIVALSRILAFFLRKLRQPQVIAEVIGGLLLGPSVFGRIPNFTRRIFPVPSVPYLNLVANLGLVLFLFLVGLETDFSLMRRNFKVSTTISALGLVIPFALGAAVSVGVYDNFVSKSVKFGTFLLFIGVANAITAFPVLARILTELDLLQNHVGVIVLAAGVGNDVVGWVLLALAIALVNASSGIIILYIVLTSIGWILALWYIARPALVWLGHRTNSYGDTGPSQSMSCAVLFLVLASAWATDRIGIHAIFGGFLVGLIVPVQIRASLTEKIEDVVTILFLPLYFALSGLKTDLGLLANGRIWGWTICVIVVAFVGKFVACGGAAKVFGMTWRESGAVGSLMACKGLVEIIVLNIGLNAKILNPEVFAMFITMALVTTFLTTPLTLAFYPKAYRIKADRARKGLPDLSEDALALGGPGDENQPRSRFAIVLEQFDNLPAVFSFCRLIQQSGDTALSLVDSADEKKDKEAEAVEAFSTHGHESGSPQGSTPSISALRLIELTDRTSALLKASESQETLIRADSLTRVFHSFARGLGLSTSLSLSITSQETYASVVAGHSEEHASDVVVLPWVLPNRQAEQGVIASYLPNPFDSIFGNDASAASGSLAYASFVRKVFADATCDVALFLERGSPAADAAPLLAGRAHLFLAFHGGSDDRACLNMLLQLIARHSGLSATVVKIERAAEATAADQALSTKNNTRDDSSSSIDTPALLSQFTVQGGGGAVDTIYPTQNELTSQTADEILLARYFDPSLARSQALTDALSRVKYETIQTVQPLHLTLASARATSASLPNNVPFVLISGRSRKDAPSHASELTDLLKQNFDRVAGGVANSSEVRRSLGDIAVGYVVAGIEASSLLVLQAKGKGGKIKNRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MFM9</accession>
    <name>A0A2X0MFM9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C005g03550 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C005g03550</name>
        <name evidence="4" type="ORF">BQ5605_C005G03550</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MFM9"/>
    <dbReference type="STRING" id="796604.A0A2X0MFM9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051058">
        <property type="entry name" value="GDSL_Est/Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648">
        <property type="entry name" value="GDSL LIPASE/ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648:SF22">
        <property type="entry name" value="GDSL LIPASE_ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY77073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="432" mass="46500" checksum="E089AE6FA77F5BC1" modified="2018-09-12" version="1">MIAVDPCQTSLGGALPPLRRAHALRPRSLASLLIIVLGCISLARVPVTVLAAPTPSGSPNTASSAAVPPEYRNPRSRRVQKRDTSMEGYSALVAFGASFTDNAHARAAKYLASIRNFAPYINGRYSNGPVEVEYMVDPTVSPAMPVAAGVTKVKLIDCECAISSPRGCLEADKYLKIIPLESHKDAFGGSVILNGLAGTEGTASAPGIVTQMSMYLSDLKTKTGNVGSGRVLHYFNSGINPVEQIWYRSIRNGLSTSATQAARISLTLSVNTYITGIVKLINDPTLVSEVVTADYMVVGIPPLDTVPSFRFLVPSRFSNSDRQQALAQLSVLSQMYNFALQTLVVQLRAAAGPISRVWYYDLTALWQEMYKSPGSYGITVSPVTTPCYSKGKLCANPKSFLYFDTLHPVTSVHRMMAQNMNVELSNPQAVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MGZ0</accession>
    <name>A0A2X0MGZ0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COX assembly mitochondrial protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C008g05151</name>
        <name evidence="4" type="ORF">BQ5605_C008G05151</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CMC family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MGZ0"/>
    <dbReference type="STRING" id="796604.A0A2X0MGZ0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013892">
        <property type="entry name" value="Cyt_c_biogenesis_Cmc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08583">
        <property type="entry name" value="Cmc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY79508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="111" mass="12663" checksum="6CC486F5DFAFD9E3" modified="2018-09-12" version="1">MSNPSTPTPHQQYALSRNEEAKVLAQCKIDALRHCEVETACTYHRSISSTDEAHPPFIHRTAFSECAEGRTVSVAWKCRQQFRVMQAMTEEKQDQAKLRYLEDRRGGVALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MH68</accession>
    <name>A0A2X0MH68_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mediator complex subunit 19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C009g05673</name>
        <name evidence="10" type="ORF">BQ5605_C009G05673</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 19 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY84054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MH68"/>
    <dbReference type="STRING" id="796604.A0A2X0MH68"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013942">
        <property type="entry name" value="Mediator_Med19_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28270">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28270:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="81"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="238"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="269"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY84054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="299" mass="31350" checksum="53AEECD2B5FFF077" modified="2018-09-12" version="1">MEAGPSRPLGPIASTSTSTSTLSSTLNGGAELSTTAFATTTGRNLASVLIAPSNMKPSPLSGSRDLISLFHLEPLYDTHLRPFIPQDSTSTGPNNSTTSDPNTPNPVHSNGKGKQSLVVDPAPSRIGISFGGIKLGALGPGALNGSGNDGKQGNPTQQQQRQPKPEKEKTYLYLVADIPGRNAIRKDSYLKHLILNPDSPAVDLRALDEDVLRDAFTLKPGTIPGFDALVWENDTEVQGGPVNKKKKKKRLRESEVGGDGGGGGGGNVVTLTATGTPNLSGTTNTSEDDHRKKKKLKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHQ7</accession>
    <name>A0A2X0MHQ7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C011g06337 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C011g06337</name>
        <name evidence="2" type="ORF">BQ5605_C011G06337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY11954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHQ7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY11954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="289" mass="31415" checksum="8F31B44FF348EAE9" modified="2018-09-12" version="1">MSAETFLAAGAHTVVAHALLSGDPEAYLAKHEPLYWTSTTKTWRQRARTPQNGRSSALDPPIPEASYVTIPGMDRPVQHYNFSEIPRDKKGALRILQEIFVTGATNFLQFDGFNLIPFSALGGILVDTITEEDCNSDWVDSQAAPPVATAPLPNAQVTSSAASDLAAVQAAIARASQDKRKEKGWPLEQRPTDTQPPGLSMPKPPPVKDNVESNIAKVLSAPPKTDYAIELCRHINVMEPDPSDEPSWSVALCKVQTQIVLSKEKKRSDPARLDSMALLLISKLDAAID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MI97</accession>
    <name>A0A2X0MI97_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C030g10852 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C030g10852</name>
        <name evidence="1" type="ORF">BQ5605_C030G10852</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000069">
        <property type="protein sequence ID" value="SGZ09197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MI97"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ09197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="55" mass="6078" checksum="495595277A7C92B0" modified="2018-09-12" version="1">MPPRPRRLILGSITSSPSFLVTSTDIQELEAGKHDVIQGYTAYLAFVDDRARTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIW7</accession>
    <name>A0A2X0MIW7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C028g10565 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C028g10565</name>
        <name evidence="2" type="ORF">BQ5605_C028G10565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000080">
        <property type="protein sequence ID" value="SGZ13371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIW7"/>
    <dbReference type="STRING" id="796604.A0A2X0MIW7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ13371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="405" mass="44075" checksum="01249B2FB074B813" modified="2018-09-12" version="1">MATASTSTSTRNPNSNADELDPATLFNFASLHLHVPRHAESTDRSSSPPPATSASSIAQLGPEQRKSVDEWVTKLAEDEERNCAYLDESLPFYLVIKLPRQPVLDRAQAAAFFLPCTSTSNSSAPITLAPHLILSADASFVEGYDPPPTNASSTSRTQPRPSLRPETTVQDPNDDDPHRPPHLHSSASASPSNANSIGLGIGQSPSLVSSLQTAHLSMLGGPKVPLTPSPLPTKREKDLGYVKEVESVPLWSCTFDTSRNESEEERDRFGMSEAKGKRKQSGGRVWVGRLGGEEGDGPWVGVWEFRGDVGQFSRKLKLRSLLGTEHSSFFAAYVRSRLVSPRLCLTLNVAFRDDPGLGEMMKKLGRQGAAAGGAQHLDGEETYDPDEYLVESFEGAPRFDPHQQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJH9</accession>
    <name>A0A2X0MJH9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C037g11571 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C037g11571</name>
        <name evidence="3" type="ORF">BQ5605_C037G11571</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000062">
        <property type="protein sequence ID" value="SGY93082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJH9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="364"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY93082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="397" mass="42724" checksum="D9CED19AA425B7D1" modified="2018-09-12" version="1">MPNSAPLRVRVPRSVTHNAPSPFGPAFGIISTYSHRVLPSPYAQRASPEAVASCAPSMQASHTSTQDRLSSFSTGGESCCHSAVDVEPMAWTPGPSTSTSTPSTAGDDSLHIAYAQLIGLSHARPYARRAVSSPVPMRTPPIPTDHGASSEPPVIIPPHFTLPDSSISRSPSTHSSLQCLAPSSLGANCHSSDLSSVQTYATEGQRAPLEPHQLQVRIIRHPIQRPPIPDFEPPNFESELCRPARVGAVRGRPNIDDFVFRGLQDLPRTLSPTLPGSNEDKLRPFTRFDFVSDLPKGKVASPDGEMTEKSDRSTASRCSRAELLARRRSSRHVKIAPWDSIDEPGKSVEDRGTTGLGLSRGWKVMLITSGVILGTLVIANLVMINVMIFSGKRMALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MK34</accession>
    <name>A0A2X0MK34_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C010g06214</name>
        <name evidence="14" type="ORF">BQ5605_C010G06214</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Gln) + L-glutamine + ATP = L-glutaminyl-tRNA(Gln) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20121"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.18" evidence="2"/>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MK34"/>
    <dbReference type="STRING" id="796604.A0A2X0MK34"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004819">
        <property type="term" value="F:glutamine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006425">
        <property type="term" value="P:glutaminyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000007">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.800.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000037">
        <property type="entry name" value="Glutamine--tRNA ligase cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1290">
        <property type="entry name" value="Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004514">
        <property type="entry name" value="Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007639">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042558">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_N_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042559">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00440">
        <property type="entry name" value="glnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF4">
        <property type="entry name" value="GLUTAMINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04558">
        <property type="entry name" value="tRNA_synt_1c_R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaminyl-tRNA synthetase class Ib non-specific RNA-binding" evidence="13">
        <location>
            <begin position="11"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="11">
        <location>
            <begin position="265"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="12">
        <location>
            <begin position="578"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGY14512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="837" mass="93586" checksum="DA18BBEEB79C2AED" modified="2018-09-12" version="1">MALPPLDRAQEDLCHYFQRCGLSEVRSTETVRSKTSLTVESFFRKHELERKSLSDKQALLMLQLVKEAGKVGQGGQAYLVGRVQDGALERAEQVTAAVKYLSSHPGPEVNEAEFNKACGVGFSATPEQVLFAVRAYVNAHKDEITKLGWPGINKISAQLKSNDDFLRWVNMLQLRDALNAVYVELLGQKPDPKAAAAAVAGKGGKAGDKKVSTIPAAAAPSSVVSDDKPEDMFGTGWLARLHKPGGNEQVYPERMEEHLKATGGKVFTRFPPEPNGFLHIGHSKAIAVNFGYAKYNKGHCYLRYDDTNPEAEEQIYFDKILEAVRWLGYEPYKITHSSDHFQKLYDLANELIKAGLAYTSDDTAEDIAAQRGGKEHGPRHDSKDRTKPIEQSLKEFEDMKNGKYKPGEMTLRMKQDMSSPNPTMWDIIAYRVLLTPHHRTGTDWCIYPTYDFTHCLCDSFENISHSLCTTEFIGARTAYEWLCDALKVYKPRQSEYGRLSLEGAITSKRKLLRLVKEGHVSGWDDPRLHTLIALKRRGVPPAAIIAFVSHLGVSPNSSLVSLARFEQTVRQHLEMSTPRLMMVLKPIKVVLENVDDDFYLEIEKSLHPKLPEMGSNKIPFTKTFYIDVDDFRADGDSKDFFRLCPGATVGLLQVPHAITYLSHEVDQKGGVKEVRCRYEVGKTIKPKAWIQWVAEHGPSCSPVKIKQAKIFKRLFKSDDPASLGDKYIEDIDPNSLTIVDGAMIETGIWEVIDQSMKRAKEIVEERKKEAEKNGTDAPPQVEGLEVVRFQGMRVAYFALDSDSRLKKGGDGATEGEDELVLNLIAPLKQDAAAGKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKI4</accession>
    <name>A0A2X0MKI4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">BQ5605_C034g11329 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C034g11329</name>
        <name evidence="14" type="ORF">BQ5605_C034G11329</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG28 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000065">
        <property type="protein sequence ID" value="SGZ00182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MKI4"/>
    <dbReference type="STRING" id="796604.A0A2X0MKI4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005352">
        <property type="entry name" value="Erg28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451:SF19">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03694">
        <property type="entry name" value="Erg28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="11" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGZ00182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="137" mass="15239" checksum="3EBCA521C01D6E19" modified="2018-09-12" version="1">MSSIQAHLPSASQGYLPYWMIFVSSLALFNSVQNFVTTSLTRRIYARSPASVTPLQARTFAVWTLASAAIRIYAAYNISLKPMYELALISYVLALGHFALEWLVFRTAALGGGLISPLIVASTSLIWMIRQYDHYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLB3</accession>
    <name>A0A2X0MLB3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C030g10766 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C030g10766</name>
        <name evidence="10" type="ORF">BQ5605_C030G10766</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000069">
        <property type="protein sequence ID" value="SGZ08057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF24">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="9">
        <location>
            <begin position="629"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="297"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="893"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="909"/>
            <end position="920"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGZ08057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1592" mass="175123" checksum="BAAEA74E08BB5E87" modified="2018-09-12" version="1">MQLTDGWITRSSVSYLVASVLPQGTDPHAEKTQRISKMATPTADHVSLMGNLYGKVDATNWGVARERLQNVLKGEGRLKHVTGVLDVGPEPLQSDFTRLEGNNQVDNVATYCNQLRLYRRDVDALDQALAQARNTLIICLGESTFARVKANATHDLWAALDKDLGRASDDFMRSAKLDALFLCEPFVDGEVLDPWLANFNRLFEDLVAAHVSRDKAYQRARIDGTLFTQSDFDKWVPPPALSEGVRMDLLKARMPRNLVTVINSIGTLPLLEQVEGAIRRAALSSSQQIEPIAEALAARVQSRSQPASGRPRSNPSGRPSGTLVPPFLQASRVPGLKERWPHGISHAGRLKLGRMQCRRCYEQGHLGDECTMPSAEVSHRPIAVLAKHNITIGTADLEDKAYKGYFVVSVPIGDDDTALYLSNIPRYLLDSGATRHMTTRWDLLINFKPFTTERVRVVGAFNSSAMATGTGTLRFGVNKASIELHDVLLVPGLSAELVSLAGLMKDGYELSNKCDAAGKHTGIVISSATSRLSFALNCNHYVLQASSHPPPRADHLALTATTLPTDVVLWHQRLGHPSWGRLVELVRSGQIPLDVAAVTPDQIRLLDQCDACCAGKTVSSPNREPASHPPDAPFSRVFADVWGPSPVPALSGARYLCGITDEFSRFRWARSIRLKSDSAAVLQDFVAMSKTQYGGQGVTTLRTDRGGKFVNHRLRDWLAARGIFHKLSTVYEHSQMGVQERSWRTIFNSVRAWLHRSGLPPALWDEAVHAVIYTLCCTNPRTRSRTPAAPASTQRPNKLAPQSHLCYFVGYSSLSKAWRFFDPVRNKVFELSQARFFEDRFFPAAVSPAMPAIPVAVGLSYPPAPLGIGSAAALSVAEAPAVAPAAAAPPPVPPALAFSNPGPANAPPDGDHSTRTRRPPDYLGFAHAAQHWEFAEHAAIQFDDFNKGDPDTQMYSFEEVSTLLAKIDSNDTPLVQAALAGPFCDYWLAAMLVEEGALATKNTFSKPVRPPPGAIVIGSMWVLLVKRNAEGQIVKYKAQLVARGDVQRRRGVHINSFSPTGRAASHRLLLALAIENKWETRQFDIYMRLPGGNIVRLQHALYGLVQAGREWYKVFTEWILSIGFTCTDSDHAVFVCKEGDRRSFLSIHINNSLLTGDGDLDGVLCQLKARFEAHSTDEASFFLGQSIRREGKTGAVIVNQGHFVDAILEEHHMANASPRPTPLAAPSTLRNRADSGFDPASIPYRAIAARFCNNFTAEHWEALKHILRYLVGTRNFGIRYQKSFQPMSAILEGFVDADHGADPVTRRSVSGYVFITEAEYVAMSYAAREGIWLRRLLADLGFEQTAPTCLRGDNQSTITLAKHPAFHARTKHIGIHFHFIRDHIVEGTIEMVWVPTGTMAADVLTKGLGTQKHYQKAAIGYLIKSARLFSEAWQCAPTVVFSPRLDYTLVSTIIHQSLPHCQQQLLDQNLPSCSSGSIRTRGGVEFHSTTSLQTLQPWAPFRLGAFLASGAFLDPTSSLAKPMPPPSHLQLPAAVLLFHRPSRVLPMHDARRSQPGLVTTDSLAYQHSTLWICFPCACRPTRLLDGPLGVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MM58</accession>
    <name>A0A2X0MM58_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Adenylosuccinate synthetase</fullName>
            <shortName evidence="11">AMPSase</shortName>
            <shortName evidence="11">AdSS</shortName>
            <ecNumber evidence="11 13">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C012g06989</name>
        <name evidence="14" type="ORF">BQ5605_C012G06989</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Plays an important role in the de novo pathway of purine nucleotide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11 13">
            <text>IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11 13">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 11">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 13">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="11 13"/>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MM58"/>
    <dbReference type="STRING" id="796604.A0A2X0MM58"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046040">
        <property type="term" value="P:IMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.170.10:FF:000001">
        <property type="entry name" value="Adenylosuccinate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.300.10:FF:000002">
        <property type="entry name" value="Adenylosuccinate synthetase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033128">
        <property type="entry name" value="Adenylosuccin_syn_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002223">
        <property type="entry name" value="PRK01117.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00184">
        <property type="entry name" value="purA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846:SF0">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00513">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 11 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 11 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11 13" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="17"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="18"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="43"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="45"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="304"/>
            <end position="310"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="336"/>
            <end position="338"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="419"/>
            <end position="421"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGY16788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="431" mass="47200" checksum="95A55F1329670310" modified="2018-09-12" version="1">MVLQPDKVAVVLGSQWGDEGKGKLVDILAAEADICARCAGGNNAGHTIVANVNGVKTHFDFHLLPSGLVNPKCTAFIGNGVVVHVPAFFEELDKLTKKGLNCDGRLLLSDRAHLVFDFHQIVDGLKEVELGGSSIGTTKKGIGPAYSSKASRSGLRVHHLFDEEAFATKFRKLVEGRFKRYGHFEYDTEGEILRYKELAARLKPYVVDGPTFLHKAMLEKKRILVEGANALMLDMDFGTYPFVTSSPTGIGGVCTGLGVPPRAIGEVVGVVKAYTTRVGAGPFPTEQLNSVGEHLQEVGAEYGVTTGRRRRCGWLDLVVLKYSHLINGYTALNLTKLDVLDQLPSLKVATGYHLNGKPLEAYFPADLDQLAQVEVQYVELPGWQTSIANITKFEDLPENCRKYIEFIEDFIGVKIGWIGTGPARESMIRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MMU3</accession>
    <name>A0A2X0MMU3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="23">BQ5605_C003g02117 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">BQ5605_C003g02117</name>
        <name evidence="23" type="ORF">BQ5605_C003G02117</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY38984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MMU3"/>
    <dbReference type="STRING" id="796604.A0A2X0MMU3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="14" id="KW-0229">DNA integration</keyword>
    <keyword evidence="18" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="16" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="15" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="16" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="17" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="22">
        <location>
            <begin position="463"/>
            <end position="640"/>
        </location>
    </feature>
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        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="761"/>
            <end position="820"/>
        </location>
    </feature>
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        <location>
            <begin position="765"/>
            <end position="776"/>
        </location>
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            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
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            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
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            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
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            <dbReference type="ARBA" id="ARBA00022884"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="SGY38984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="854" mass="94485" checksum="745394B194F9B678" modified="2018-09-12" version="1">MSSGAPDFDGHRGLYSCAWAYASTLGLGLRTGAGPRLTIFDLLLAPELLTARQKALLKQDAKAQSLILNHLDSDNAVTARACMTAHEMWNSLHNNHVGLISDQVRYLTAQLRNLQFSKGKEIVKHFITLQDLFTRLDELGQSFDDIYKSNLMLDSVTHPAWASTLDNLRPRFSPRSTPPVDKLSDISPTTLAARISDASQGNGGKRGGSQRNRGPKRKPNCVCTACGENGHWSIDMKCPQHKQHSEWKSKSGSSAVDANTVTEMSTNHTIYSIGESSGAALLRNTWIGDTGAHRHFVGDCSILRNFTHDPVMVRVANGSPVFCKGYGSITVRTDKNHTLNIQKVYHLPGAQQGLVSFKALRIAGAKLLFGDDGSTINVHVGNSIVASTKIDTDYNFSFTVVPEEPVDAVTRSSTSASLYSWHLFFNHISQLSLLALHCAGAVTGLRLTDTTVVDCESCILTQMTATPHNLQFRGADHVLYCISMDLGFVNYEDFQGRSIYLVIVNQFSNAKFTYPLVSKTAAVVHEAWNLFITYAERLTGQKVKFVRSDNGTEFVNRLLSDEFRRLGITHKTTARYTPQQNGQAKRANCTLFDLVCAMLKYAGLLRKYLSYALASATFALNRSLHPSKRKTPYELYTGHKPDVSHLRTFGSTAYALLPRALCKKLSDHSQKGIFLGYSGEYNYLILVDRNTTPKVIITRDVTFSDIPSTSSTPIIDIQSDPHNFVVEHLYEYKMVPQLRPDQNFIELEDYAHLPVAPRADVPGPAVAPRPVTPVSPAPSTLAGDDDDHPSRPVTPDPVSDNEADNLAYPNDGHEYRPYNVGRNLGPLENINEDNIVRRAPYYGPQALEIEIVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNE7</accession>
    <name>A0A2X0MNE7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C021g09277 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C021g09277</name>
        <name evidence="2" type="ORF">BQ5605_C021G09277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000083">
        <property type="protein sequence ID" value="SGZ20445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ20445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="149" mass="16039" checksum="D747C8BF65AE833A" modified="2018-09-12" version="1">MTPNSSPIRGLATTDSNADRRDEFGCREDDGEHAESEREASEGEGNEQAWEVLLHDILVQASNNAIIANCTSTSNLAPKTVSGYEKSLKFYTKFMAETWPGACFKRPARGSGTGADQGEDIEVTTIGVLVLKNASIISRLWLVTGLSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQZ5</accession>
    <name>A0A2X0MQZ5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C019g08921 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C019g08921</name>
        <name evidence="3" type="ORF">BQ5605_C019G08921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY23267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="796604.A0A2X0MQZ5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="2">
        <location>
            <begin position="225"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY23267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="413" mass="45533" checksum="8D2D8834A9AA6BD4" modified="2018-09-12" version="1">MTRSATDPQVKLEFEGPPEAKRVKLSPSIGSHMAQAATKTEPQAKQDPGKTNTLAVQAQGSFERAVEVERALLPRPRLPVELAAPGPRGYTSPRVASFQRNTTTPEVPANTDRVSELTTAVVGAQAQLAHPLPLVPTHPVPQLAAPNTKATKSKSRRKRPKPSKPPKPANQPKVKVRKSMTHDDDPMHALRPRRNPFSTLIPPHPVFWRSPGIQPNLTALPPPLLIRSLDLRLQSVTHLSYYLNGSNNVRLSKEESYVKCFRPLEWFGDAELKHYVANILVKKFPSLTHASYTLLAAMLIQNDTISYIAWAYGLGDLMLFGKVAHGEESFAHHQDALANLFEAMLGALVKDRGPEGEAEIKDWMGKIFSDEVFPELNEKAEAMREWPLKEKVPDGEAVDVLAGEAVVETVAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MR61</accession>
    <name>A0A2X0MR61_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C027g10417 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C027g10417</name>
        <name evidence="5" type="ORF">BQ5605_C027G10417</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MR61"/>
    <dbReference type="STRING" id="796604.A0A2X0MR61"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018255">
        <property type="entry name" value="Ribosomal_uL16_CS_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001197">
        <property type="entry name" value="Ribosomal_uL16_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003239">
        <property type="entry name" value="PRK04199.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00279">
        <property type="entry name" value="uL16_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11726">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01257">
        <property type="entry name" value="RIBOSOMAL_L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGZ28705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="238" mass="26808" checksum="3ED18BD70379F75E" modified="2018-09-12" version="1">MDILFDIALNRTSTALHEPIGDDDPHAATGTARTSRTPRYNRGVPDPKIRIFDLGRKKASVDDFPFCCHLVSNEYEQLSSEALEAARICANKYVVKTSGKDSFHLRVRVHPYHVIRINKMLSCAGADRLQTGMRGAWGKPYGTVARVNIGQIIMSIRCKDSNKAVVMEAFRRAQYKFPGRQKIIVSKKWGFTSLAREEYIAQRSTGIMKQDGCYVQYITPKGPLEENLRTLERIAAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MSV8</accession>
    <name>A0A2X0MSV8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C046g12281 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C046g12281</name>
        <name evidence="3" type="ORF">BQ5605_C046G12281</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000112">
        <property type="protein sequence ID" value="SGZ30961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MSV8"/>
    <dbReference type="STRING" id="796604.A0A2X0MSV8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46731">
        <property type="entry name" value="F-BOX ONLY PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46731:SF1">
        <property type="entry name" value="F-BOX ONLY PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25499">
        <property type="entry name" value="Beta-prop_pof12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="92"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ30961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="735" mass="80181" checksum="446B3DC1DFB4398C" modified="2018-09-12" version="1">MVKLKRARSRSRSPSLDREQSGGNDDAGSASTSTSTSKCRNGHPRLRFKQHQHAPATPVTASSTTSSTAATHRGRGAAPVAPVPWTILPTLPTLEGSLAEEIVLRCLSYLDVHDVLKLATVSSGWCRLTHDNQLWKQLYTRTYTPSATSHTSSTASFSRSWKDLYKISFNWRRGHARTSVLRSSVRKAVLPPLPLTIDEPNHGSHTTGADTETPLNRPHPRVVRPFAYPPTATARSRVSPNSALQSNTLVQFYRNIYFLGSRSTHPSSVIPPVQVQQALPDGSTILLGEIISSNLLASYQQSSAGFTPAVSITSIQLDEAPNTSIDTSHQVELAVFLSTGQFSLFSVTLPNSTAPFEWQEVHTSPLTTASTKAQSFDPVVLARYHGSLLATCSRSFVMRFYHVIRRPAAGTFGGSLVIEASDRLQTTESWAPVSLSLEKLPDPFASDTHDHRKRSKASSLPQAFKLVLAYATPIFPDSWSVGVQQFEVTLTPHHDALNLSGIMIKSQHAVARLAAGMFASPTYPHLSSSRASLVTAIEHLGDHVVISRADNTLDVYLLTADPKTEHLGIQHIKTLFGHTARVSSLALVPGTGDRVSATAPATSSTMRTTREHDLRNSVSAGHVVSASEDGKVKIWALGPPRQHSKRSTGVVPSAPIDVTETGRTSLSFDESKDRAQGVSTWVQLASKRSQRQRETVLRVALDMEKIVTVVRRRRRPGNGDEADGEEEMIRVLRFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MTL5</accession>
    <name>A0A2X0MTL5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C002g01467 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C002g01467</name>
        <name evidence="4" type="ORF">BQ5605_C002G01467</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY33222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MTL5"/>
    <dbReference type="STRING" id="796604.A0A2X0MTL5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF31">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY33222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="365" mass="38710" checksum="1EBB63224A91672B" modified="2018-09-12" version="1">MSLQTPLTDLFKIKHPIMLAGMNVAAGPELAAAVTNAGGIGVIGGVGYTPKFLRDQIHELKEYLNDKSAPFGIDLLLPQVTSAEAEVALRSCVGGSARKTNKDYTGGKLHELVDIIIEEKAALFVCAVGVPPKDVVDKLHKAGIVCANMVSTLFLKFKKAVGAPKHCLKALETGADVIIAQGGEGGGHTGDVPTSILIPACVDIVKGRKSPLTGKQVPVVAAGGIYNGRSLAAALSFGAVGVWVGTRFVCAEEAGASKAHQQAVLTADHNDTIRSLIYTGRPLRIRKTPFVMRWETEKAEEQKKLLAAGKIPVGMEDVENRPHLMGAVAAVIKDVRPAKSIMEEMIKEAVETIQKNQGYLIKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MU76</accession>
    <name>A0A2X0MU76_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C079g12962 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C079g12962</name>
        <name evidence="1" type="ORF">BQ5605_C079G12962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000120">
        <property type="protein sequence ID" value="SGZ34072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MU76"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ34072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="57" mass="6038" checksum="824AB4C511550CF4" modified="2018-09-12" version="1">MVNQGDISLSHVGTSDMVADIFTKALGPKVFSTHCYALGLRTRHPRLGSASHSRGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MUW9</accession>
    <name>A0A2X0MUW9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C007g04699 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C007g04699</name>
        <name evidence="1" type="ORF">BQ5605_C007G04699</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY62494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MUW9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY62494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="49" mass="5478" checksum="6E99FDDCCDF9D5C2" modified="2018-09-12" version="1">MYRHTVVSAAPACGVHVPIRSHVPALCRLSYFSCRSNEATAFPVFSFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MUX4</accession>
    <name>A0A2X0MUX4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g01929 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g01929</name>
        <name evidence="2" type="ORF">BQ5605_C003G01929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY37966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MUX4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY37966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="170" mass="18835" checksum="D81EA12FB5B6966F" modified="2018-09-12" version="1">MCCLSCLLPATRQRLPLPPAGEVGTAVWYVLQRRQILVKELHESRPTAFGLIGGVFAGRAKQVLRRSRGSPRHFGRRLSTLNNTQIQSLVTESSRSSSGPSAVDVRHTTIDLDAFRRELGLTTDPAAEHAERDRDDVYERRVEEVLGSRSEHEVEEEDDAELGEGDGESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MVW0</accession>
    <name>A0A2X0MVW0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C004g02772 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C004g02772</name>
        <name evidence="2" type="ORF">BQ5605_C004G02772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY67399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MVW0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY67399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="721" mass="77189" checksum="D6F0788B0779DA56" modified="2018-09-12" version="1">MALSSKREPVPTVQLDATDAAPRWPSQERHRLGDASSSPATLIADASAGTSADGARSMEKVVKNDRGTPSRPVNQPQHQRSRSWLAEWLKSGGATPSAIQAADENVPLPPSLGPRSSIIRTKSESGGRAIKTRSVLGFRRKTRRGSQSEQAVAPVALVPTPSPASDVPPRRPLPPTLTPDQDFVALRSPLNATPHHTLPAAALAANKRTTIAPSPATSAGFPTCQPSEIGRPASWNWDGGSGNAWPAPNRVSDPDAPSRDRIDSFSSVYSHDPVDLGEIWDDLVTEGEISLSHLIPTRSTNVFPTTPTSALATYDFHGEHNEHDVSTHGRTSHNLSSDNSEISFVSLSAFPAPPLASDAVFEYASTLQSASSLAERRGRKQAIPALIIPQSLVALAIDSASDDGCEFGGDGFPVGGPTMSYFSPVTPPCGATFAFDLSASTGSSRSSSQMAGLAISHAPSTDQSDVDEAASYEQERSTFSVSDVLARHLPVSKNAFLQPFQPPTLPRSSASSPTFGERSDSEQAPSSTLTAISTFSSNLWSGSESNASFETHASSVEDEDYLDPPPRCSSRRGGIDSSFDPSWSIASTEADGNSNLMLEGSSVDEQSMGDSFGRGKRWIEQEMKGVGMPGNDSTRTDETRVTIPEAMHVIHHDDEEDILESEDRTLRLTDAFGKKEVERRRVEAYDWGETRVVEPFMMASQRTNCEEELGTNEIVAWGVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MW34</accession>
    <name>A0A2X0MW34_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g02419 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g02419</name>
        <name evidence="2" type="ORF">BQ5605_C003G02419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY40767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MW34"/>
    <dbReference type="STRING" id="796604.A0A2X0MW34"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039905">
        <property type="entry name" value="CD2BP2/Lin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138:SF3">
        <property type="entry name" value="CD2 ANTIGEN CYTOPLASMIC TAIL-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138">
        <property type="entry name" value="PROTEIN LIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY40767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="521" mass="56908" checksum="0CDAADD0C391EC3A" modified="2018-09-12" version="1">MAPKRPAESLARPNASSSSLAATQPSSSTGGKRVKFDAATLNATNSGGANASATEAELEEDDLLNPSTARKKVVTDGYDSDSSADGSEDGFGGVGGGRKGRKGTGAEKEKEGEGEGEDEDDDMFDGGHDEGEGVAKRNTAEKSKKKEFLEMGDIEGQEFGKGEDEEEGQEQDGAEEDEEEEYALEDDLANDDDAPRSRRSKKGMGYQLSSFNMADELNEGRFSADGTYVRNNDDPLATHDKWLDGVSKASIRAARESKKRMDEQARKKEEEEARGAEAMAQQRDDCLIGLLSLVRPGESITMALNRLGKRRRKVAKKVVRPKVRDGDEAMDLDEQTTTSSEVSKGKQREEEEAEDVDPAVKMIDRITYLASTLLAQGELEIYDTSYEAIIQTLKEEGAVRREWVPPVDPDIAKEEEEERLASLAQPRRGLIARPNVVTARPSSSTPQAVATAVNPNGRKFFYKWKVPQADQVPNQEYGPFGTEEIETWIQGGFLGPQGANIVVRVEGQGGQAWTNWQEAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MWU8</accession>
    <name>A0A2X0MWU8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C004g03102 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C004g03102</name>
        <name evidence="1" type="ORF">BQ5605_C004G03102</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY70098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MWU8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY70098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="99" mass="10708" checksum="A21166DB48F09D1D" modified="2018-09-12" version="1">MKVPNVSNPSDSKANSFANKLKRYGDSLAADAATTHLAGGYKRNGRFDHQAFLFDTVTAKMKRHSGIRTAPQNTLSDHALQAVCSEVVEDPVNNLSFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MWV8</accession>
    <name>A0A2X0MWV8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C004g03112 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C004g03112</name>
        <name evidence="4" type="ORF">BQ5605_C004G03112</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0587 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY70159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MWV8"/>
    <dbReference type="STRING" id="796604.A0A2X0MWV8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008584">
        <property type="entry name" value="CXXC_Zn-binding_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857:SF0">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05907">
        <property type="entry name" value="CXXC_Zn-b_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141678">
        <property type="entry name" value="MAL13P1.257-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY70159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="214" mass="24644" checksum="E6477B62DF9A92BE" modified="2018-09-12" version="1">MVKLQVLIKAFGSYHLQATLENCTDLQAHGDDFNWMFRVQCGSCREEHPNWIGIDATESHEISGSRGEANFVWRCTMCKREHTISKFPFLSPHLWYRLKRVTDQFPTPIAHFNHQTPYCTLADFDPSFNRSKAFYTFDQSESQKFATIAILECRGCEIIKFDPKGIWHCKGVNSGTVFDEVELELSNPDGWTDYDEKASEPVGVSEFESKIERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MWZ2</accession>
    <name>A0A2X0MWZ2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C004g03152 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C004g03152</name>
        <name evidence="1" type="ORF">BQ5605_C004G03152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY70457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MWZ2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY70457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="102" mass="10943" checksum="82E5C1A3677C5E63" modified="2018-09-12" version="1">MDVLARFHFDTTTRGATVPMTPGLSLTAVLGQGTERIRSWYLQAIGSLLYISLGTRPDIAFAVLYLSRFANNPAAAIGSPSNTSFATFALRVVGYSDANWGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MY99</accession>
    <name>A0A2X0MY99_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C001g00634 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C001g00634</name>
        <name evidence="1" type="ORF">BQ5605_C001G00634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY48261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MY99"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY48261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="82" mass="9450" checksum="7E488F29614CF671" modified="2018-09-12" version="1">MSPVDELTVGELLAFEFTRPDLTATLTVSEFATFEPTFHQHQIRPNSTTRALFNKSHEPRWNDSRRRTILEEASVCIAPWCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N4P4</accession>
    <name>A0A2X0N4P4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C028g10494 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C028g10494</name>
        <name evidence="6" type="ORF">BQ5605_C028G10494</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C15 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000080">
        <property type="protein sequence ID" value="SGZ12302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N4P4"/>
    <dbReference type="STRING" id="796604.A0A2X0N4P4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.20">
        <property type="entry name" value="Peptidase C15, pyroglutamyl peptidase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016125">
        <property type="entry name" value="Peptidase_C15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036440">
        <property type="entry name" value="Peptidase_C15-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402">
        <property type="entry name" value="PROTEASE FAMILY C15 PYROGLUTAMYL-PEPTIDASE I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402:SF1">
        <property type="entry name" value="PYROGLUTAMYL-PEPTIDASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01470">
        <property type="entry name" value="Peptidase_C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53182">
        <property type="entry name" value="Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="48"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGZ12302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="289" mass="31474" checksum="9825C207FF3222C9" modified="2018-09-12" version="1">MTPLPAHDHSNKSKPFHVHITGFGPFGEHTINPSWQAVKQLHQTTLDSRPAPLAASSSRSKSSITATSPPSSNGSSSTRPIHFTSTLIPVTYASSLSIVPQLHTTSTGPKPDLIIHVGVGAPYSLTLEALARKFSYDKPDVDQTYAPLDHETGYRGFTGLGEVFDRSDEVLHSSIDVDKVLRASRGEGGGVEFLRISKDAGLFLCEFTFCASLAWAKFLATTHSNDVETARRDVDRDIPNEKRQETPVQFIHVPPVGLPYSLPELTQALRIIIWAIVNEGGLSFYSAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-07-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N574</accession>
    <name>A0A2X0N574_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C005g03626 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C005g03626</name>
        <name evidence="3" type="ORF">BQ5605_C005G03626</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0045 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N574"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029756">
        <property type="entry name" value="MTH1187/YkoF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002767">
        <property type="entry name" value="Thiamine_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051614">
        <property type="entry name" value="UPF0045_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00106">
        <property type="entry name" value="MTH1187 family thiamine-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33777">
        <property type="entry name" value="UPF0045 PROTEIN ECM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33777:SF1">
        <property type="entry name" value="UPF0045 PROTEIN ECM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01910">
        <property type="entry name" value="Thiamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89957">
        <property type="entry name" value="MTH1187/YkoF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiamine-binding protein" evidence="2">
        <location>
            <begin position="5"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY77396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="98" mass="10750" checksum="CFABBF64A03058E6" modified="2018-09-12" version="1">MHAVADFCLIPMGIGEVGVTKYIAECQRVLEKSGLEYKLHGCKLPNVIEECHQAVHAMGCPRIATDIRIGTRTDKQGSLDNKVSSVQQLLGKDEAKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N904</accession>
    <name>A0A2X0N904_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C026g10189 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C026g10189</name>
        <name evidence="2" type="ORF">BQ5605_C026G10189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ27791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N904"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ27791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="78" mass="9173" checksum="219D5E91E3DD4452" modified="2018-09-12" version="1">MVLEMTSTGRWRMQRHGTRMESVERRRVVLEERMKLQEEQGAGEGSRASRGWVRFPPTIPHTPPPNHTSSFKKKKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N970</accession>
    <name>A0A2X0N970_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">BQ5605_C035g11370</name>
        <name evidence="17" type="ORF">BQ5605_C035G11370</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 16">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000064">
        <property type="protein sequence ID" value="SGY96927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N970"/>
    <dbReference type="STRING" id="796604.A0A2X0N970"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000096">
        <property type="entry name" value="ADP,ATP carrier protein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF14">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="11"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="116"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="218"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="SGY96927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="315" mass="34347" checksum="EDDA845F7B757B7E" modified="2018-09-12" version="1">MSAGKKSKTPQEFFQDFMMGGVSAAVAKTAAAPIERIKLLVQNQGEMLKSGRLETPYKGIVDCAKRTYADEGLVSFWRGNTANVIRYFPTQALNFAFKDYYKSLFSYDRKRNGYSMWMFGNLASGAAAGATSLLFVYSLDYARTRLAADNKSSKKGSTGERQFNGLLDVYKKTLASDGIAGLYRGFLPSVAGIVVYRGLYFGMYDSLKPVVLTGNLKGSFVASFMLGWCVTTFSGILSYPLDTIRRRMMMTSGEKVHYKNMVDAGAQIIKAEGVASLFKGAGANILRGVAGAGVLSMYDKLQELLFGEVKFAGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NCX0</accession>
    <name>A0A2X0NCX0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C021g09284 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C021g09284</name>
        <name evidence="2" type="ORF">BQ5605_C021G09284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000083">
        <property type="protein sequence ID" value="SGZ20526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NCX0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ20526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="339" mass="38444" checksum="E8145CE36A520259" modified="2018-09-12" version="1">MYLKSLFLTRLRPSGPPVVDVPAYCCVCRTCAEATDTRLEPDGADSHMQRSTLTKLESMLRTGNRFVREFASAKARAGWDTAKEWILRLCLPPGRDRRTHNLPTSSTEMAMLICDSDTNMGDPRSIRLRCLSGSHYYFLQGKMASTPTFLFAGFAELGCQSPETESRSTMVSNRARYLRVSVLMTEAKRRTKTATMRMKTARKGTKRMVMANDEVQVKGSRWRVSRSPFFAHYLPNATSTSQSRIAPNVPSWKPTPHHDPRHQRLDPEPNRDITQRYQDAMACVVKEEKPPLLITMTACNRPDLIARVFEAKSGNKRHAGCFGDECKMNRFCFFAVLCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NFZ5</accession>
    <name>A0A2X0NFZ5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C027g10352 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C027g10352</name>
        <name evidence="1" type="ORF">BQ5605_C027G10352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NFZ5"/>
    <dbReference type="STRING" id="796604.A0A2X0NFZ5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ28488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="557" mass="62121" checksum="0DB528D4CB43DE56" modified="2018-09-12" version="1">MTKCSSWQSYLGQGCNKQRSILIDLWHFFDRIYVSKKHGAAKAFARAFSDAVFIPNADDRLLIKARLAKLGMTWEEAVRSPVWNKKLWRRSKQPLFNKAAHEAAKRCLEAIRKGQLYTDLGPCGGPDGKADDGVRLYSCQRDTNSLEGGIHRNLHQRFPKSGVSPCHVNACMADYVLVHNLTVSPTPPSQFDEAATILTHSPLYSQVGTFNRTGKPFVGHYDLWLTVELHHIVNPLLYTPSTESFGIVPVVQSPTAQMRFLIEPCQVERGTLRLEPVKWLPRNLLQNNTPAIQHMQSRLPTDRKLRHDWPAERQGTRFDVLFVHTPSERALYRYLSSKVRLGALQNLQIFEITEPWNKYANGLDIFYKMPEHINTWAPRWSSLANAKATMNMGGNDVRVIQASFADPSRGCNVSMLAATPLLGHKPPVLGSLTEVEVDFSDPSTSSIRAFVATASSAGSSADLGTSNALTRAGTTKGARHCRLCGQTTCRRKGSKLSDDGSVTECDGACLDCGKPFGLTDEMDPNDPQSRRSYRGLTRAEMNGRAWHQKKCHNFVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NJ02</accession>
    <name>A0A2X0NJ02_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C069g12854 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C069g12854</name>
        <name evidence="3" type="ORF">BQ5605_C069G12854</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000131">
        <property type="protein sequence ID" value="SGZ35057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0NJ02"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="693"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1201"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ35057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1406" mass="158788" checksum="DD3E35863E7F5DD4" modified="2018-09-12" version="1">MIIDDGQTTITTVSRESTPRSPSWPPLSPETLAKSLREGAEWDRANAEAAARVQAENEAIINAQLDAQEPLVRHQFAEWGQEDGQLRFINIRGTGSRDPSDDPVDVKRVLNRVKGRAGKEVAGQGKRVTRSMSAAAAMQVEGPRRKRRRVKGWRRRSAGQHYRQEHVYIVYPIMIKHLITSWNVRRCMGIPEKRRDIYTYLSTFKASAILLQEHFIKPELWQCIKDEYEGKAFISKHCLTLIPADSPLIDAEILRTHSALDGRILVTSFRLRGDIRILEINNLYAPVDTKQRLTFFDKLHFHRTQSTHLRLLGGDLNDCPLPAIDRRNQGRHGHHWPILIGKLDSPYTDCIRFKHPLTPSFTRPNIVRKRPKSFSRLDYFLLQRTHQKRLVQASTIYDHPKDLSDHRPVSIVLVLSDERGDAAQPNNSLPTTSNQLHRINAATFKTAAFQGMLEGWLEGASGEEPVGELEVVLGNCEKEGRELARREHRERALPVMGDEETAEWTRTTEELRRAVNERARQLRIRAHVPEIATEERLTAIAQRELTHDIDVALDHTQAHFQRLYNLEPRDRDHVERLRDDFLAPIRSARTCDDPSSDPLFLRRLSEAHIELLQQPITEDEVVAAIATTHPGRSPGPSGVPYELYHTAPRAWAKALSRAFNAMTERGSLSPRQGQGLVRLLFKHHKIGADRAELSSYRPITLRECDYKLFTKVYVARLNHVLPDLLPPQQHGFVKGRRSADASFHLRLLIEELGARGTEFPDAALLSLDQSSAYDLVEHEWIFAIFDALGAPATFQRVLRMLYSGDSTTARYIINGFLTPPVRLTCGLGQGDPASSSVWDVVFQPFLDALHRRGIALNLSLPTIHPYPQSRAIHLLRLPMTSSSPSRLRSPLTLLDDLALDWRLATNGRLNTDKTVVLPIGAEGESLEWIGLSFDPTGNTELANVNLVARLEAVLDSARDRGLTHHTRAVTNHAPQFLSPDRHEVVKELDRILVDFVRGGKRRSCYGKDVVFTPRFKGGLGVMRMQDVVDSVAARVWDVLLGGSDAIWQGLARAAIVRAHPAPDFDLATDAWPCDYTPIRTDLHPRWQAVLKVPSTHNAQVKPRTLTLANLLALPIKLHTLHYLPGAPAVSRSPYDADYAAFANYAKVADLFRRELYPAGAFISGRRRRMWSSATANTINGAAHNESTLWHAQPVAAVRINGPPRVRPRSEVRPTTPLESILPHPIDPPQRLPRPALPDQSTQYNLLSMDRPYTIRRVRRVLNAKAFTDTIGFRDSLQPDDLKGFWKGVNSKALTAREREVWFKLVRNFTPTRSLQFHQKHDDSPACLVCGAPKDDREHYFFDCVDSGNVWIAARSVLCDALGLDTIDNTITRLFNACSDFRSSRPVYAIKKERGGRSNIHRADLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NQC8</accession>
    <name>A0A2X0NQC8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="24">BQ5605_C015g07721 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">BQ5605_C015g07721</name>
        <name evidence="24" type="ORF">BQ5605_C015G07721</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0229">DNA integration</keyword>
    <keyword evidence="18" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="16" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="15" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="16" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="17" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="23">
        <location>
            <begin position="678"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="910"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="928"/>
            <end position="943"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="SGY17247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1352" mass="151542" checksum="3EAD940D0A0405AA" modified="2018-09-12" version="1">MGANWVEVVIASESEARDSWAQYSLESVQLELYMVASGGNETTESLNATQPPPETPEHISEAKHNENNSGVDLSGMATETQFMAATELQKLKELGPLRHENSAEWFRRARRLFDTTGTSLHIDFEITKPAKRGEKETEDAFYTRAQCWTKVDSQGLLVIETCVTKDTWVSIGGNMHSSFRQVWDALKKRFDRPAQGFTLKILFSEFCTFDYKPGEDLNDYLDKLLDKRREIERMKVSNFRAEMGEDKWNTYNKALPSEAIETTIAIDKFLWKAIILARIPRDIAERIRHLDDNESLIDAARDLWKERLDREKKNASTAKPEQPQVISITPGCVPGCRCPLCQPDLYPKVFAAQAVQPLAAKKKSQAKGALDYQNYEKWTTLGGRIMNNKFVCGYNQCWNCWGAGHLKQACPHLATIDRELLRDRMLRSLGITIGSRNQAALFVEFEGPGVATSVIGHGHFVTAYGASNNPEDKRINDTELIYNTGATCSISPHWHHFSSYVPALSKAYVKDAGGHLHLIAGSGTVSPQFVLDSGLIKTFNIYNVLHVPTMVATLISGPKLYDRGLHSSCDGKVFRLILDGQTVAICNVGDRMVFRARPISPNITDSAYALMSHSSSADLFTWHERVGPVGAAALKKMEKEGLARGLRILSGGRSVDFCKACGLGRGAHTSVPKIATTREAVPLRKLFTDVWGPVKYPSLAGHTYLLSIIDDASRFHWIFPLKHKSEVTQHIIDFIECVERERDLPVVKIQSDGGGEYVNGALKAHLAAKGIEHIVTVPYEHHQQGIVERYWRTLFEGVQSCLAHSNLPTSYWCDATQAFAYLYHGRIPDVHHFRVWGCNTTVNLPSHARQSKVSPPGVLCTFVGYSPLGWLFIRHDNSRLIQSSDARFYERSFGRKVVAPTPPVAIDIFEGLDRPDDEPAVAVPAPEEAPEEELDEAHDDNPDDQPRPGYEHVIPTGERTAELANRWGAIPGTRRRPIVDDGNFVELADLLDDDCHRLPLVGHIDLSRCDGGWTPLADVVGDLDTKHIVGDCYELWTGNPDEPTFREAMNGPDRQQWCVAYARELSNHEGMGTWDKEESQPPVGRRAIPTKVVLLKKRNDRGEVLTFKARLVARGDLQKPGDYGTTYAPTARIASVRILNVLAHVHRWRRQQRLPDKTVHCLRRSIYGLKQAGHDWNQTLHDELTKSHGIVRIKEDRGMYRRVREVGGKSLTLLLAMYVDDGIITGDDDIEEFLLAFGARFKLREGEVDMFLGMKITVDETRGELCMDQRHLAESILATRGFTDCKPASTPWLDSYSPSGHVMDTSFPYCSVVGELLWLAGCTRPDLSFTVVEAPRAAVLQNDRQDQTIVIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-05-29" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NRU3</accession>
    <name>A0A2X0NRU3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">hydroxyacylglutathione hydrolase</fullName>
            <ecNumber evidence="5">3.1.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glyoxalase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C014g07646</name>
        <name evidence="11" type="ORF">BQ5605_C014G07646</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21864"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58896"/>
            <dbReference type="ChEBI" id="CHEBI:71261"/>
            <dbReference type="EC" id="3.1.2.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.6" evidence="5"/>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY19432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NRU3"/>
    <dbReference type="STRING" id="796604.A0A2X0NRU3"/>
    <dbReference type="UniPathway" id="UPA00619">
        <property type="reaction ID" value="UER00676"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004416">
        <property type="term" value="F:hydroxyacylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07723">
        <property type="entry name" value="hydroxyacylglutathione_hydrolase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01374">
        <property type="entry name" value="Glyoxalase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035680">
        <property type="entry name" value="Clx_II_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032282">
        <property type="entry name" value="HAGH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017782">
        <property type="entry name" value="Hydroxyacylglutathione_Hdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03413">
        <property type="entry name" value="GSH_gloB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935">
        <property type="entry name" value="BETA LACTAMASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935:SF94">
        <property type="entry name" value="TENZING NORGAY, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16123">
        <property type="entry name" value="HAGH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="10">
        <location>
            <begin position="11"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY19432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="254" mass="28076" checksum="82D227B9C2DD48A6" modified="2018-09-12" version="1">MKIVPVPCRSDNYMYLLSDGTSNSAAVVDPYDVAKVHDAAKKEGLQVGQWLLTTHHHADHSGGNDDFVKAHPGVTVTGGSDKSPGVNKLLKHQETFDIGTLKVTAIHTPCHTQDHICYYVEDTKSDERAVFTGDTLFVSGCGRFFEGTAQEMHEALNKRLAQLPDDTKTYVGHEYTKSNVAFSSHVDPENPAIKSLVDFANKNEVTTGKFTLGDEKKHNVFMRLGSQAVKDKAHSQDEVACMQWLREAKNNFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NRX8</accession>
    <name>A0A2X0NRX8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C014g07686 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C014g07686</name>
        <name evidence="7" type="ORF">BQ5605_C014G07686</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY19570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0NRX8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF51">
        <property type="entry name" value="SNF2-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="712"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="1175"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="90"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="251"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1392"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1396"/>
            <end position="1410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY19570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1442" mass="160484" checksum="F03A8E224DAB693A" modified="2018-09-12" version="1">MVPVTPHEGSAMRGPPTPLSALHACSSASSSNPTLSEIVDVKHVVRLNSAASHYIETLPTPSHSRPASPPSLDWLMGTATIVDSASSICDGPQLPLSSTSGERPLKTTPPPTSYGTSNELLRAPKEPGWRTIRDWEQTIADDHCRVRERANPEIGSESASRKKTGTQLIPLAKLIKAGTIVLRGYQLRDCNGSAMVVDEDGWFRFAAESVVKIGSDDAGPTTMIDDDDPDAASSTSTIAFTSKLPYDGLLPPASPEPIRARAKRKAKPLWTRRSSKKSIKSATSTSPSALQHGTGDPLLEELRLLTSALFLRATCRPLDLSDGVSDVEGDKRVVIFRIYLVPDDLEERFNETYTKGRRVRPPSSVILEFLQKIKVGQREWDGSVDGHEGGDGLLDEKDQRSILELYRAVRAPPSDPSFVETLQDVDQHTRDRIRDTMLENPLAMMTEMFPYQRASLAKMLTRELAPRWSIDPAYTVKTEMGNKGAEDMGAKFYVSVEGRISKHPVFVREPKSGILAEDMGSGKTCICLGLILATKGELPILDENVGTWLDGEEGSPAPVVVSQLSMGFPFQTELKEARRLRPRVPEPLLALSEMDAADVLEYEEALRVQAIRDAREDVLPPVPTLRMLMIDYLSTMPRAVPYPVDDGRFESLRIAAEIANFPPFYYVHPSSAQLQSRQCRQIGFGARRCAKETFGPDTGKMRIQAQEMMMTRTTLVVVPAILVKQWETEMAKHLVPGALKVKTIKTPKDRMITVNEVMAYDVVLMSIARFSEAADTGDNVLRRIHWKRLIVDEGHALSGANKMRDLAEELRCEARWAVSGTPSVNLRAKADTLPAAASKSSGTFAALDMHAGGSELDYRRLGQLFSRFLRHSSFSRVEDWRKIMTVPILEHSRGATRLSRVFDETIIRNPLEVVRQVVQLPPLTTRVVYLDMEELERKTYNALLALFANNSILSQRTNKDYFFHESQKSALNDLVSNLSASSFFFASRGLVSQIRFTIKSALDEGFTTEKAKKFSDEDRQGLKRSIEVMQEAVDDPRWCHVVDVMSVATVVRSVDRSVADMFQGLYLSGDDESGNHLMSLGSLITLRGDLQEVRMPDIGAWDDDEELREELLTFEAKRLRETSAVSGSIEDIRAKEERKRLNKARKFAPRPLRPRPFPSDSSFRNVSMGRTTSAKLNYVISECRRYAQEKFIIFSCALPDLVFAILSEAFDLVGIKHMIFAGHARGANRGTMAQQFNESSVKDCQAILVDARLGGRGLNLTAASRVVMLEPLWQPDLEIQAIKRAHRLGQTRPVDLSILVVRGSYEDSLLQRRSQLSANEIGETKLPQRDEKLRGVLQSAEYLEPPSVDGKVDEKGKGRQVDNERTFLFGLGDDDTENEVQIFAEVESGPLVRPTIEQEERGKGGAEKLATRKKRSLIPDPTFTDEPHGPKRAKKSVQFAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NSM1</accession>
    <name>A0A2X0NSM1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C011g06329 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C011g06329</name>
        <name evidence="3" type="ORF">BQ5605_C011G06329</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY11938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NSM1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY11938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="196" mass="21849" checksum="8F411DAB5D5B9B26" modified="2018-09-12" version="1">MMRNDGSSRFRTDSTPPLIVESSIRVVSEDGGGTRDEYDETRSNLSDEAYWAHTAGHFGLMSMTEVTRDNVAAWELGAIEPTTSTTTPSSSTSSPAQGSATSSDTIQHQHLDEDDDPIVQVVEPTWKAVPLRPRKETRFERAEERRRQMTEEEWLIRVKKRRRRTLGLIVGVCGTVVVGTVVICAIFVAQKRRDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NST1</accession>
    <name>A0A2X0NST1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C011g06379 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C011g06379</name>
        <name evidence="2" type="ORF">BQ5605_C011G06379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NST1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY12074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="86" mass="9301" checksum="CCA50A48D0EB49E7" modified="2018-09-12" version="1">MTPMIHWEDGVTGGAGGRRGSACSHLDPENILDLPDYSRFYAEVREGLFTGGMYAKGYPTQLPVTVDEHPRRLAQGFPTLGSGHPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NU57</accession>
    <name>A0A2X0NU57_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C010g05986 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C010g05986</name>
        <name evidence="2" type="ORF">BQ5605_C010G05986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NU57"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY13824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="481" mass="52542" checksum="887FBD15CD32279A" modified="2018-09-12" version="1">MPVPQTPSSDSDSDEPNLGDSSQSSADDSDSESDSHSHSESEFEDVAIDHQRAIRLWTAIHGSHRNATGRMSQRKWTSLKRWAARRYYSELKMAAKLGISHARLVQAVKKFNRLASKGNAWSRFLSDPVIKVLHQRASKELDQSKAQSITKLAAQLWNFLRDQGDLGSAQLGEDDEEVVRAAFAVAEAGNNTTFTSIVPPTIITRSPSDIPSPTRMEQCKKYIAELQDLAQRMSKLYGVETLAFIVPRYQDDVSPATKATVHSIGGLRFAAHCNDFKDPSGNSLLSNFASKMSWDETLKANEAADLKEAKTRSMDSATRGVLGKWHGTLFRAQLNSALETIHRRSDTGSSTGDFTPQKKMIWSTQGLKALGVKLRIKPGTKSRYEMALHHSAETSPKQTVAQLKAIIDDLRHGHLAIVPSVDPNDNTEAEASDDDSNGGEGPLSPRFGGAGDEGGEVRGGEKSGEEDRERNTEGVAEETGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NUJ7</accession>
    <name>A0A2X0NUJ7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C018g08681 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C018g08681</name>
        <name evidence="3" type="ORF">BQ5605_C018G08681</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY25919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NUJ7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6570" evidence="2">
        <location>
            <begin position="271"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY25919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="451" mass="51625" checksum="087B26597EFAAB48" modified="2018-09-12" version="1">MVQPSSTVEQHLGAWLDKRQSLLPTWRAMIRCSLRQLALSNVKLRLEQLQIICQTHNLQGYSFRRSRARELFLRILLSSCTETCPACESGYIFKRSTAIDILVPRRHCVPRHTVYRHKTLESCQAELSKRRAATNNDSRADDDTRLRRTTQASQAERSSPYTPASARLQAEIRAEWNQYFTDAKFRVFCCLICSERVFGHEAHWVAESVLKCRDRGILEALTDVHLRSDLRPTTYDFEEWRAAIIDPRGLHRRNDLEGQPIYFATDEFSVQLVTARARAYKIVYKITKFGDPNAQQKCTRGNTLIFSQNTAAFTDILPMSVEQLADSVCVLFCGAEANLTQLDSCRPMIVRQGKVKRMLKWLSHVCGFSREHLPPERQQPQHLIRKIGLELVTSEALATQGMESELRCLFSEHAATAWNLGSGQSIEVNMPNLTTKPQVVFTHHQLIIPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NVP3</accession>
    <name>A0A2X0NVP3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C013g07298 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C013g07298</name>
        <name evidence="1" type="ORF">BQ5605_C013G07298</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NVP3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY15239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="146" mass="16768" checksum="19A1CE29FF02FC02" modified="2018-09-12" version="1">MPWLMKKRWSHFVLLHQLPRAICKHTHNIFLAFGFPLWPVHEHRSVVVDQHPVAVGCDHDVRSGNVPMKDAAHTLNGPQNNACQRFGRIDDADWFEAVFMERQLHRARLETPRSEGEIRREEVGDDDKVTLAIHVDDVGEPLSILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NVQ2</accession>
    <name>A0A2X0NVQ2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C002g01184 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C002g01184</name>
        <name evidence="7" type="ORF">BQ5605_C002G01184</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the MSS1-MTO1 complex that catalyzes the 5-carboxymethylaminomethyluridine (cmnm(5)U) modification at the 34th wobble position (U34) of mitochondrial tRNAs.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MnmG family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY30821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NVQ2"/>
    <dbReference type="STRING" id="796604.A0A2X0NVQ2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070899">
        <property type="term" value="P:mitochondrial tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.570:FF:000001">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000002">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.570">
        <property type="entry name" value="GidA associated domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00129">
        <property type="entry name" value="MnmG_GidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049312">
        <property type="entry name" value="GIDA_C_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004416">
        <property type="entry name" value="MnmG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020595">
        <property type="entry name" value="MnmG-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026904">
        <property type="entry name" value="MnmG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047001">
        <property type="entry name" value="MnmG_C_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044920">
        <property type="entry name" value="MnmG_C_subdom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00136">
        <property type="entry name" value="mnmG_gidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="GLUCOSE INHIBITED DIVISION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF0">
        <property type="entry name" value="PROTEIN MTO1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21680">
        <property type="entry name" value="GIDA_C_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13932">
        <property type="entry name" value="SAM_GIDA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01228">
        <property type="entry name" value="GIDA_assoc_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01280">
        <property type="entry name" value="GIDA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01281">
        <property type="entry name" value="GIDA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain" evidence="6">
        <location>
            <begin position="615"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY30821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="703" mass="77131" checksum="0522F43EA18108BF" modified="2018-09-12" version="1">MSLQSTRASIRSLLYNLPPRLGSSSTYRTFATVVEGTSSSVATDGSTSSPPAYETLVIGGGHAGCEAAAASARAGARTLLLTQRLDMIGEMSCNPSFGGIGKGTLVREIDALDGLCAKVCDVAGIQFHVLNRSKGPAVHVCTPKVLLADRSQLTCRSSPQGPRAQIDRKLYKREMQAVLSKYPNLTIRSANVKDVVLSSPLDGQTERKVVGLRVDQGEVIPCKSIVISTGTFLGGETHIGLEITPFGRINEPAAHSLSRSLKGAGFELARLKTGTPPRLRKDTINYDGLLQQTGDRPANPFSFMTDRVANEDNQVSCYQTATNAKTHEIVSKNLHTSIHIRETIKGPRYCPSIESKVIRFGDKLSHTVWLEPEGYDSNLIYPNGISVTLPAEMQLEMLRSIRGLENVEMTQPGYGVEYDHVDPRELDHTLETKRIRGLFLAGQINGTTGYEEAAAQGVLAGINAGLSALGKDMMILSRADGFIGVLVDDLVTKGVNEPYRMFTSRSEYRVSLRSDNADLRLTELASKFGVISEARRSHLESTRSTLHAGIAMMENFILPPEYWNIRGFDVRRDGIRRSAFDLLHYKGVDVTRLEGVVPGLDGLDPKLKERIYIEGLYKQHILRQQHEVSLFQRDENLIIDPSVDYATMPGMSTEVRQRLDQHRPKTLGQAKRLEGVTPASLVGLMKWVRKSHKGANVAPVEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NVX6</accession>
    <name>A0A2X0NVX6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C013g07378 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C013g07378</name>
        <name evidence="3" type="ORF">BQ5605_C013G07378</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NVX6"/>
    <dbReference type="STRING" id="796604.A0A2X0NVX6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39336:SF3">
        <property type="entry name" value="PYRIDOXAMINE PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39336">
        <property type="entry name" value="PYRIDOXAMINE PHOSPHATE OXIDASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY15476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="271" mass="30014" checksum="292D13D1B24CC073" modified="2018-09-12" version="1">MGAFYDTVPNETLMDWIRQQKLFFVSSSPLSSDAHVNCSPKGHDALFTLVDDKSAYYVDLTGSGNETISCLYEGGNGRITILFVAFEGPPRIVRLFGKGKVFERGSPEFEKYLPPGDPRRYPGTRAIIWIDIHKVGTSCGYSVPFFEYKKERNTLLNFMDNQEKKEGGMKPYWNLKNSSSVDGLPGPKVAEPDAPEPREKFTLEGSGGGPNAGIKMGKKSEGGDVVQDLMARLAMLLLGLFFAGWLLGLRITFDEGVAREARQRLWGTLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NW43</accession>
    <name>A0A2X0NW43_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01354 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01354</name>
        <name evidence="2" type="ORF">BQ5605_C002G01354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY32360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NW43"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="422"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY32360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="518" mass="55977" checksum="BBB160D8A2C8C21C" modified="2018-09-12" version="1">MTIAHAHKLLDQELLTVPEALLGQHQDVRQALVSLWFSAARSGTSQQKQTQRFVGSVRAEADRIVAATAGQIHLVIVFDHASARPALKARRTPMSRDNGNGVRRSPQVSPDNFQRRSPDRHTDPMTEWLTNFGGQGEPTLAGHVFDMSSEVTVIISAHEADPLIAASTRVGVIGGVRVQGDRAALASRDSDYFMVIGSERARYRIIPSVKHRVVRVIDLEILEGQGKFPGAEGRFVAGLMMGCDYLPTGIEGYGPTKLEKLDRSVFQLATWSQGYEHATAVLHRVGAKLTAPRAIEHSPRVLFPDTSFDGGSDEHLRRQGHGFEMGPLQPFAFIRDRKTPPEAAAVRRLEAVQPGRCASTRQIATKGAVGADGFHLLTPECPIVESASEGSNKAKKKKITTPAPPRVKAMSAKQGRWAHAIASGQSATTSTGDSDGSKGAEALAQVYRIFTMSGALEDLVREVDGGGPGPVEDSKKRRRKAKQTRRRHKKGRKATNPSTSSGTSQNSTETASDAMSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NXC7</accession>
    <name>A0A2X0NXC7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C014g07540 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C014g07540</name>
        <name evidence="5" type="ORF">BQ5605_C014G07540</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY19027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NXC7"/>
    <dbReference type="STRING" id="796604.A0A2X0NXC7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398:SF4">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="459"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="205"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="212"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="348"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="385"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY19027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="556" mass="60806" checksum="7437589163D91CFC" modified="2018-09-12" version="1">MAQKPISTTTTTTTTTTTPPPSTSLSLRQSLLLAQAVNALGTTSWDAISQLVVASPFVHQTTTTTTSATIPDELTRGEGCRTAWERLAKEAEVGEEVRSKSTPWPPKGKSSLPLPALLYSTHAPPPLLTHAITHAITHAITHAITHPSLPHPSRRPPARPLRKIVRKLFSALLHTTHAAITSSLAQEANCKKQIQAIRSGNQKEQILGELSPRTKERYLSGLREQDRKDRIEQPEEKDATKPKAIKKAQGVKKEDVEVKKDETEQEEEDEEEEEEEGEKEGGDLTDDSTATTKKRPVGRPKGSKSNAAPTTTVKETTTSATTATTRKSTRAQGKATTTTHEDSPEPTANEDEGEVEDEEQTPAPEEEDDDNEEGDEEGDEGSTRSTRKGSSRKAKGAAAASAAAGLKRSRRKTSEMAASPGPSEDSRSKKRVKGENEVESGSDTKAFRKSMNMLLDNLTNEGYTHPFKDPVLKRDAKTYYSAIKRPLSIQEIRKKLRSPDGYTNASQVARDVALVCANARQFNPSANKDPDDLAGQAERTWRKTEELMQLHMSNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NY40</accession>
    <name>A0A2X0NY40_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g02126 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C003g02126</name>
        <name evidence="1" type="ORF">BQ5605_C003G02126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NY40"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY39024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="52" mass="5809" checksum="5F2ABA1B4410B771" modified="2018-09-12" version="1">MYQHTVVSAAPACGVHVPIRSHVQALWQLLFFSRQSNEATAFPVFSVTFSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P096</accession>
    <name>A0A2X0P096_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00501 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00501</name>
        <name evidence="2" type="ORF">BQ5605_C001G00501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY47161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P096"/>
    <dbReference type="STRING" id="796604.A0A2X0P096"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY47161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="233" mass="25658" checksum="6764083FD1DB403D" modified="2018-09-12" version="1">MQPILALRHVYEPAVQLCRTDSVVSAMANSTLGSPHHHHLRKGECAGLESRSNPSSPTFSQGKLLQGSDSEAVAFRENARSYNNALSFTSLAALWDQTQVGTLGPPVFRVFGRLYHRLGALIPAVTQRPTFAQTWLIDPAEATDTRLGPDGADSRMQRSTLTKLESILRTGNRFVREFASAKARAGWDTAKEWILRLCLPPGRDRRTHNLPTSSTEMAMLICDSDTNMGDRGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P0P4</accession>
    <name>A0A2X0P0P4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C125g13327 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C125g13327</name>
        <name evidence="2" type="ORF">BQ5605_C125G13327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000023">
        <property type="protein sequence ID" value="SGY27503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P0P4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="455"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY27503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="536" mass="55767" checksum="B665854F7CBCD7E0" modified="2018-09-12" version="1">MPDPPGAQAPPPDNPLGGNRASDDESLNTLTREPVTGGTANPPAWSTEATQARLDCEKVMQNTFRVLGIVPSGKSTRRLMVLMHDASTPPSQAPLLARAAQRAVRNDAAPASNVIRVIMDGPGSPRGPVQIALRKHFGLAETPFMFARPEGVVLDPEVEKLFSKCVKLNPIVTKATKRFPIARHMYELVFESDQACLEAAAAGPFSHHGKEMVTELPSASPLNHVVQVRFTLPSSSSATPASVLRQSLDDALTLSFGRAGRTQGYTLMQLQRGLAVDPNGDPMAMTEDGFHCAYLRLHADLFQGSTETQKAALNAALPQEIEILGAKYGLRHEFETHYCAVCDRAGHQWGACRKPVSTPATAAPVPGASTSTSTTGFRVAGKNGKHGGPAALNSRASGTNMIQLGPRANPAGAATGNKDDANDDDGDDDDDGGGESVASTEPEGGDTGKETLTRATTGPTKETQTTTAAPVSTPTSPSPSTSAPASPLSGGTSESSATSTTSIASTSPRRLRSSSAPGNRRVTRAGSAMIHGASGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P0Y0</accession>
    <name>A0A2X0P0Y0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C002g01058 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C002g01058</name>
        <name evidence="3" type="ORF">BQ5605_C002G01058</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY29489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P0Y0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY29489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="495" mass="54492" checksum="37891F799047BE5A" modified="2018-09-12" version="1">MSSAFDPMEEGGQPMAEIGDAGTELRKFASCSSDNCGGPFKHCGGETYFKEPSSASQPPKRGAIATMSSATWLQPSQAGLDAARVSIPGMGEYKTTHFNGSQLLKRPSIVAYFTELFLLGMITAKAVTYFSRGSRDPTIVKVCVSFSVLILWCKSSLNIKIMWETRALPWPILTSIIISQIPVTLSQSYLCHQLWSISKKRLVPNAIAIAGTLWSTILFIIYAALRVKYPMPGGSQDRAQPWVPPWAFCNCITNIYLSLTCSVFLLRTRKEAVGDQLDYMLLRLATQSIATCLPPALISAIMAILEITTSTGQAWTFFTIIIASVYVLCILHTFNARDDILEEARSRATMKISSPMATGSNRTVPPGQRLTRPTAIGLARLHSLRSESTSLSFPTNFLETMTAPKRPSMNSPVELEDTSSGPFSIYSEDHQLRSLQDGELTKSKNESQDQRAADAAGKKIQVHVLKKTDSSVEWCEVDRRRSITMRCASASERRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P3B7</accession>
    <name>A0A2X0P3B7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g02051 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C003g02051</name>
        <name evidence="1" type="ORF">BQ5605_C003G02051</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY38594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P3B7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY38594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="47" mass="5677" checksum="721464BF16CF143B" modified="2018-09-12" version="1">MDLRARGYLRTRSPRRIRARTGHYTRYSALMRAQPTQSTRFLGFFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P509</accession>
    <name>A0A2X0P509_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g02581 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">BQ5605_C033g11241 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C003g02581</name>
        <name evidence="2" type="synonym">BQ5605_C033g11241</name>
        <name evidence="1" type="ORF">BQ5605_C003G02581</name>
        <name evidence="2" type="ORF">BQ5605_C033G11241</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY41880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000066">
        <property type="protein sequence ID" value="SGZ03006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P509"/>
    <dbReference type="STRING" id="796604.A0A2X0P509"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY41880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ03006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="123" mass="13311" checksum="6B899546E58AD632" modified="2018-09-12" version="1">MAGCQRRPTGAPSDSGGECVGRGTGVLARANVKPSLALTLARSSARETLFYQHVFPHLPDHLRKHLPQYHGTYRGTNGNGYVMVFEDVGAVMNELSDFYGSPRCGKFLKSGALNPATTTTRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P821</accession>
    <name>A0A2X0P821_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C006g03971 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C006g03971</name>
        <name evidence="4" type="ORF">BQ5605_C006G03971</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY55118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A2" evidence="3">
        <location>
            <begin position="361"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="773"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY55118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1358" mass="149159" checksum="4C96B4822A99255E" modified="2018-09-12" version="1">MDTSSPLTTGAHPTIPAKQLAALTSLLSGLTTATSATLSGTSRTAFPKHAHLDGPKTFASWTRQLRLCLADDIRSYVLDGIVPANWTPSHRSARDVVARELLANSIDSANVSAVLDQIPTADLTAPKIYSTLKLRYAPDDATRTLELFSRLWSFRPMPGTVGEFDGWIMEFKAIAQEIIDTKTTINNVLATLLLAIAHPSLESFKVSFTDEQRTQRSLPAIDSLADRMRVQLRSTNVPSTQSALLAPGTLAQPRGSLAEDSGRATPLLVDRILASSSRPTRPTCLACRSPSHRVAQCTVRAKHPPPGPCRSCKKNHWSFDCKKALENSNRPDTADSTADSQHHVGCLATGLLAHRRQLRANSFVIDSGATSHMVSDKSLFTNYRHVAPTKIGGIAGGINAIGTGNIAFVAASGHPIMLTGVLHTPGLPVNLLSVSRLCDTDNVRVAFTKYGIHIDKDGKNIAEGARLNEGLYLLDTDHSKCQQLAFLSRSQSSVPLLTLHRCLGHLAPSSIQKMVATGLLEGLGAGYSDEEVEKFVCNACLSAKGHRLPFPDSDLHSSERLGLVHSDVLSLPERSLTGKQYLVTEVFGVFKTWLAEVELETGATLKVLRTDNGGEYQRVNRSIVEGVLALLADAHLPKTFWEEAAAYFVYCKNLCQHSALDKETSNSVWQGERANVLALHPFGCTAWLTVAPELRSKLDPKAVRVLFTGYDLASKAFRFYDTTTKKIILGRNASFLDTEFPSLLGDSTEEDADTHFASAPIAEPQDTVKTWTPLPQVRLDPPDVHRPDFSTYREPASAEESPDELDLIGRHSRDESPDEIDFLTRHHRAFIATDDDTSDAEAIQPVKSITSDPQTWREAMSSDKREVWARAANDEFNSMRDDFKVFTIEDRSTVPTGATIVTSKFVWKTKRNALGEITGHKARLVAQGNRQRDGIDFNETFAPVARFSSIRSLLALAAANGLHVLRLRRSIYGLKQAGQIWNRHIDASLRDLGYTATGTNHCIYSRLDDRQRPHYIALYVDDLLMISLDLAEIERVISGLEQRYGVKRLGPAEYILGIQIRRLDDGSIALSQERYIMEVLARFHFDTTTRSTTVPMTPGLSLTAIPGQGTEQIKSWYLQAIGSLLYISLGTRPDIAFAVSYLARFANNPGSRHWIAVKHVLRYLRATYRDELLYARGETRITGVVGYSDANRGACVDTLVSTMGYVFYIAGSAVSWSSKRQSRVANSTTDAEYLALSHAGKEGIYLSQLLEELHVQPVAPAHIFTDNEAAAAVAHDPIRVSGTRHIRLHEHFVRDMVNRGDISLSHVGTSDMVADIFTKALGPKVFSTHCYALGLRTRHPRLGSASHSRGGGGCEEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P9I6</accession>
    <name>A0A2X0P9I6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Exportin-T</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Exportin(tRNA)</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA exportin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C009g05795</name>
        <name evidence="13" type="ORF">BQ5605_C009G05795</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <text evidence="9">Shuttles between the nucleus and the cytoplasm.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY86016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P9I6"/>
    <dbReference type="STRING" id="796604.A0A2X0P9I6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071528">
        <property type="term" value="P:tRNA re-export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045546">
        <property type="entry name" value="Exportin-T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040017">
        <property type="entry name" value="XPOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952:SF11">
        <property type="entry name" value="EXPORTIN-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952">
        <property type="entry name" value="EXPORTIN-T/LOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19282">
        <property type="entry name" value="Exportin-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <keyword evidence="6 9" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Exportin-1/Importin-beta-like" evidence="11">
        <location>
            <begin position="118"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-T C-terminal" evidence="12">
        <location>
            <begin position="394"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="796"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="798"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF19282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGY86016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1159" mass="127522" checksum="888A3B252C9FBBCD" modified="2018-09-12" version="1">MDLSSLSAQIASACQCALSPSSAPAQRQEAYTFLQRVREAHGETWQACLALFLERHDGAGGQTGYKWDGDARMFGVQVVGESLPHLSAEALAFVQQSLVEYFQQEYITYGKAENGVAYLKNASVHLITVLFVHTYPQQFSSFFSTFLNLLRLYSPSHQPAPTTPPPLNPLTADLLLRLLHDVSDEISDAQLRLNKLPHRLAKDTELRDAVREHDAPAIASSIWEIISESLDGISTPSSSSTTLDDLVGLKGKRARDILEMAMRVVGDYVSWIDINLMVTPSTIALLLRALNLPSTSEALSIRTAAADALLETISKGMPPGDKLALLSVLDIASVLGRLVEERDASMLQLANGKAAAGAPSDDEMDAFAEKFAKLLNGVGCELCKICEDNNASNEAKSAASVSTSSIFPLLLRLLTDQNDQVAMAIMPFTHTLLSRYKKDKKRSQNVPLDAERSAFLTALLKAAIVKMQYKPDDEWMLSKDGEEDDEELAFLDLRKNLRQIGDAIAILDPQLYSEVIQSTIVPTIEAFEQGATLPWQRLELSLYLLYGFGQAILVTGPLAFSVVPQGELDRAKKEAEYRVDYTAFPLSTLGELLLRACRANVVEFPHPSVALQFFEITVRYSDFFRLCPEFIGRILPSFLDEHGLHQADEMIQARMFYLFSRFIHQAKHIVQTRVSGQVIQEILSRMQDLLTINAELDASDASVEGLVKAASTTTFFDAQLYLLESIGTLIWILNQMPDEQVTLLRAVLTPLLSELQANVRPTASSAADYASVLKAHHLIMATGNVAKGFPDATNLKVTPTATPSGSSPRSSGPSANISAAMARSTSGVWVEVFKEATESMLAAAKSMSSFVVIRDAVRFSFNRIVATTGPAVLHLIPTLIDVLLGEITFPELAELLSFVGLLVAKYKTSILEVLDTLLLPVFNRVFHFLKQPITGTDDEIQHATLRRAYFNFILSITSSNLQQVFYSEKNQSSLSSILSSVTHYIALDNAQISDQRFGFIVLNKLLSLWVVSPPVPATNASSGQPNTAVLVMEESPVPGFETFLYSSAIPMCLQVPLRPNFDLLDAQSFQMMGEIASLLKGLYLKRGDEFTQFMMGEYLPTTNGWWPQGAAEEILNEITNATDGKALKKPLCEWVRKMRRALAQARQEVAANNNNNAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P9S9</accession>
    <name>A0A2X0P9S9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C007g04582 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C007g04582</name>
        <name evidence="2" type="ORF">BQ5605_C007G04582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY61652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P9S9"/>
    <dbReference type="STRING" id="796604.A0A2X0P9S9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="SMART" id="SM00262">
        <property type="entry name" value="GEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY61652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="941" mass="99987" checksum="5DAD74D5BA289CAE" modified="2018-09-12" version="1">MDHDHFSAYQEASRVQSVSAYEPVSSPLPPVTLPAFPSASVSPGASKYHTRRRSQHPPHQQGLPSPSGSPSPRLGSSFSAGTGSVGAHQSGIMSSDAAAQQGGDASLEEEIERSRQERLRRRTHASDPSDGEISDPRDTASARENIIALASRGAQPSAGASGGASLASFMGAAKAPPRHRIGTGMTEQEKEETERLEREMEVTRSKWKNANNGSSPAGAAPAGVSLATLMKGNKANESSVKVGVASRWGQTVEKEGMGTRSLDATGLPQKKEAAAMSLAAIMGSKASGPRLNQPAPQAASEEGPAHARRGFVGAYALPGMVAANSPGMRASAPSESASDFDFAPRRDAGRRSSVLDRWNRDTPSGEAASTAPPPAKQTSTPLPNTNTSAALAPSAPSRGWSGPPIGVKDTPHASPKSAPVRPEGLPEPKYTRGTALPGMNAPTPAAAPTVESAASISRPSSPTSVRNVVAQWGHASQPSQTAAALAALSIKESYGIKVASPRTSPVVSNRTLPSTQTERVSQPAPTDNNFAPKPVPTLARNASPPVAPAPMVEGLPQFSSSAAPRSSQDKISSAAAPSKLSTDSKAVKAAVALALNTPSPTRLPPGIAASTDVYSLLTQDRDPIDHNHMFYRTEILAIVHRQVSPDSTTVFIWIGDETPPIGHRVEGQINEILKREGVHEAQRLRYRQETKALGEVFGDQITICRGLRDEFDHLATRLYSVQTVDEVAFIEEQDLTSRSICSGHCTVFSIVGEVYAWMGVASNAQEQDACFEFAESIADGRQVTILQQGKETAYFWHGLDGLEIASSYYWRFRPLLPPPVSVIAFESTSSIRRIEPIDLPKNHVSLVDGGFAEHWIVVPAMCKGKKAEIEVAMAAAEDLAGRWKERGFGFKQAVHVLCAPSKLPIDLPHLARQLDFHKLNGNEKPTKMNVLTLEEARAQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PBW4</accession>
    <name>A0A2X0PBW4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C005g03168 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C005g03168</name>
        <name evidence="4" type="ORF">BQ5605_C005G03168</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY72402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PBW4"/>
    <dbReference type="STRING" id="796604.A0A2X0PBW4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000237">
        <property type="entry name" value="GRIP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01465">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00755">
        <property type="entry name" value="Grip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50913">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRIP" evidence="3">
        <location>
            <begin position="920"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="274"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="531"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="892"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="664"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="777"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="226"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="543"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="900"/>
            <end position="916"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY72402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="970" mass="106873" checksum="85E9CA88D776A6AA" modified="2018-09-12" version="1">MREPPVEEVEEVPVKAVESVKESPAEEPAVPVALNGTVEIPEEGPVVELESTNSDAPAPAIELLATPRDVEEPPALVESEAGSGSASAIEHVVPEVADVHATAVEEEPEVPVEAEAEPTPIEPEESAVEVAPEPSNDSEEDLTPKEEEEVEPIAAPPSPLAPVVQAPSTEPNPAQPKVESLEYALPQLPPVSTLNEPVKDIVQPPTSTLVAEPDLREAEIESLAVEEPRPELEVVAEKVEPEPEPEPEVKSEPVLGEQEVKIESEAAAEVLAEVNTEEPEIAAPSEVKSDPEVTISEPEKPLPVPVPETEPEPFVAKEEESLEVEREEALAVPIAARMGEPFVIDAAPVSELESKSEETAPRGAADGARLAELTSAHDRLSTLKSSLDKVVTTLFPALTSGISDVGAFEGHVRGLQTKAESSTAEVNKLNGQLKKQSDRIEELRDTHRLEQQSSVADLDALRDSLDTKDKLIASLESRLNHATSSSQDAQSLASRQNDEYTKLKLIAKEEEEKRVKALSLLRALRQKLVKAEKDKENAEEERDTAKADQDRANETLKSDRARFDQEVISLRAAQELQLSKMRSSFDREVASLRQQHERDSAAKKSQAELDVITLKAAQAKEIALRDARIKELEETVKGVTGSRDETFAQAQARAAELEARAASQMSIESQMKELEFEVSELRDRNAALVDKAETLRKQQRDVTRDESAYRRALADAEARHEQKVKDLETRIRKLEMDRIETDEDWGRNLQERLKEVERMRLAMAQKDLDYAESVHRMRDRETKIEEGEKQRKELAAQLFEVEGLLKALKDDNEKLVQAEAAAREELNDKVDRITALENRVEELQNKESSLRSSHKALREELRKLQSGVLLSEKQRNPGVGFFSSFNQSSTSVATDGTLQSPPIGSSPSTISTRSGPAPIGDDEALNFEYIRNVILQFLERPDMRPHLVGVLGVILHFTPAESRRLAAKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PF09</accession>
    <name>A0A2X0PF09_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="5">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C023g09674</name>
        <name evidence="9" type="ORF">BQ5605_C023G09674</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="5">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ23980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PF09"/>
    <dbReference type="STRING" id="796604.A0A2X0PF09"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="148"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="391"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="556"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="683"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="564"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="683"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="695"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="717"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="755"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGZ23980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="796" mass="87230" checksum="C4F9BA32C41429FB" modified="2018-09-12" version="1">MFGTSLRLARTLPSRASALVRPHVLSLHRSVVVASFARSLTTTPSSGYAQIASGRVGGRVSTSGSRAVYDDTPVAIEDDSAEVDADPEQRPAATFASIKDTLHAPIFKAITQRPFKYETMSEVQEAVLALLPRLSNPPLPTTSQDGASESIEQAQDLLVRAKTGTGKTLAFLIPALEGRLRQLEAYKVQWERDNPDAPKAQAERALNKYAKSSVGALILSPTRELATQIATEASALMSHLPDMGVRLFVGGASKSLQYRDWVRSSSNDIVVATPGRILDFLSSEENVRAPLSAARMLILDEADTLLDMGFADALADITGYLPDIAQRQTFLFSATVSKQIREVARKSMKQDHVFVDTVKASDIDTHLHIPQYYTVLPDPKSQLIHVLRLLAHDQLLHARKAAANGGEQGGKAVIFLPTTRMTQMFSLVLQAMKAHFPWARDTHIVEIHSKKDQNQRTRASDSFRKNKTGYSILVTSDVSARGVDYPGVTRVIQIGVPGSRDLYIHRVGRTGRAGKEGRGDIVLLPWEGKYVSSQLRDIPMQHFSVEDGEKALNEAAEEWDQDPPETRVTAEAESRGGFTKRTSKSIRDRRVGFVRAPQMSSPVAPRLESLEDSLRTSVLPSLDEEAVRDAFASMLGYYAPRSSDLRVTKSEIVQGLKDWATGSMGLEQEPYVSSMFLAKIGMNDRGSSRNNSSGRFGGSRDNGGSRGGRPSSFDGYRSQRDSRPMDSRINSAGKYASKKNPPRAPRDGGYKPRAFGSESSYGSSKPSFGYGGSSSPYDNDRGDRRNNRRSSPSSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PG00</accession>
    <name>A0A2X0PG00_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C009g05739 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C009g05739</name>
        <name evidence="1" type="ORF">BQ5605_C009G05739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY85099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PG00"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY85099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="365" mass="41278" checksum="F00E48981AE9E60C" modified="2018-09-12" version="1">MYPLEQRPVGQRLPLEVLERIAFHLGSPFDQAFQRPSPSVIYSYLRMGSLVCRDWRPAFQRRLVSEVVLAGWRPARPSPWPMARKLLASGLGKRYPVDRMHLGMNPLDDDFDTDATEIFAGLDPVDWVSDRDKDSKLPKPVLPLLEKLEISSSDLPGVMDLPLNVEMPRLHNLQLYVNRRASQNPTILAKWVEVLFGGARSALSGRPASTSAALYETVKLNISHLERLEDCIRAVGSNGAPCHSLKIERGESDCEPEDLSRLWAILTSSLKTDPWDYLEILHIDLTYKCLELAIEIPHLSTLLEAAKQSRAVELPKGQYLPDTTPEEMALEQPLRQWTRDRMAEAGLKDACKDKEIGLGVVYRYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PI77</accession>
    <name>A0A2X0PI77_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C047g12325</name>
        <name evidence="12" type="ORF">BQ5605_C047G12325</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="FQNC01000113">
        <property type="protein sequence ID" value="SGZ31173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PI77"/>
    <dbReference type="STRING" id="796604.A0A2X0PI77"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46077">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TOPORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46077:SF1">
        <property type="entry name" value="TOP1 BINDING ARGININE_SERINE RICH PROTEIN, E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="94"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="153"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="345"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="544"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="605"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="345"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="406"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="422"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="491"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="554"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="574"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="620"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGZ31173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="794" mass="88911" checksum="8ED6C4CF20CCD371" modified="2018-09-12" version="1">MPSPKRRRLSLDNDDEDRIPLFQKTASSRQLSFDLTASSGVREPRRSFSRPSRDYDRDRDVLRRRSSASEDEVGDRGHHHKTDEDDDDDEVEHCAICLSPIHNKTVITPCLHSLFCWECIRAWSDQSRKAKLIYNIRSNKDFQTHHLVPLRSPSTSTAAEDHRLLATSSSRPASSTSHRRPSVTSLPRHALYGRRNESATSPAAGMDEATWREQVNERALERRRFVYRQGLFAKHVASNRYTGFKPFGPDKLNNNTIKNKVLVFVRRELQVFSSVDVAFLTTYILSIASQLDLRSAAAIRLLADFVPQAQAEHLAHEIVTFARSPFDKLEDYDRFVQYGRPEKVEVPRGEERDREPRFGKGVDSRRGWEASNGRYDRGDHDSRWARRVSYDRRGDEGSHYRIRSKDRHDRGNDHRDTRRRSPSSAPRSPVLAARPPPRAPSRQSLNRPPSPSRPSSRHSNLDSTRPTATLEPGADEGSSGILSLFGTPLREPTPPSHSVPPPTNGVTFSTTHEAPDASAGAAKVSLSIFGIAKSATPMVNTIERTKSKTTIDEVSPVSPVSNHSPEPSSTSEVRSSESQRRSSTISREELQSRLMAEYRTALSNKITPPPHVLAEVSPSSPSPPSPPPVVGPSSPPLPKTITNWAARGQLAARGLELKQKLLKKRLRVESSITNSQISPKTKDSLTIEENPSRNILYDDPMITSKKIIYSEAKGQLILERLEHEKQLITQAVSPSPSSLLEPSSIASTEIALASEALLRRTLQANKSEKRAGELKERLYKKRLMRESKGKVEGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PKX6</accession>
    <name>A0A2X0PKX6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C023g09709 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C023g09709</name>
        <name evidence="1" type="ORF">BQ5605_C023G09709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ24137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PKX6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ24137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="474" mass="52545" checksum="FA2774330A3D5FA0" modified="2018-09-12" version="1">MYQHTVVSAAPACGVHVPIRSHVQALWSPGTQGGPSQPRQVLGARVAPYHGLPWACSSARCWAPRGSTLLFAPHRSTESAPRRVMTKMQPILALRHVYEPAASAPGSNRAQTPQAHISIRDDLGPQTAVCTHCKARHWELGPPVFRVFGRLYHRLGALIPAVTQRPTFAQTWLIDPAEATDTRLGPDGADSRMQRSTLTKLESILRTGNRFVREFASAKARAGWDTAKEWILRLCLPPGRERRTHNLLTSSTEMAMLICDSDTNMGDPRSIRLRCLSGSHYYFLQGKMASTPTFLFAGSTKPGRQSPETESRSTMVSNCARYLPVSVWMTKTKRRTKTATMRMKTARKGTKRMVMANVRFFSSFSDLPKATSTSQSRIAPSVPSWRCDGVCCQRVKVSAADHDDVRPRLTGNQGCTGADSACNRPDLIARVFEAKSGNKRHAGCFGDECKMNRFCFFATVQLSCYFLDFILPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PM16</accession>
    <name>A0A2X0PM16_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Catalase</fullName>
            <ecNumber evidence="11">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">BQ5605_C026g10183</name>
        <name evidence="15" type="ORF">BQ5605_C026G10183</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8 12">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="11"/>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ27766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PM16"/>
    <dbReference type="STRING" id="796604.A0A2X0PM16"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08157">
        <property type="entry name" value="catalase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000001">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF62">
        <property type="entry name" value="CATALASE T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="7 11" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="4 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 11" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="14">
        <location>
            <begin position="16"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SGZ27766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="512" mass="57762" checksum="B83A55FE6BC1072D" modified="2018-09-12" version="1">MPSSQVRNQPDGATYTTSQGAPVNEPYAAERAGTNGPLLLQDFHHIDLLAHFDRERIPERVVHAKGSGAHGEFIVTHDISDLTCAQVFEKVGTKVRATARFSTVGGESGSPDTARDPRGFSIKLRTEEGNWDHVYNNTPVFFLRDPAKFPHFIHTQKRDPQTHLKDADMFWDYLAQNPESFHQVMILFGDRGVPDGFRHMHGYSGHTHKLVNKNGDFVYAQFHWRCDQPRKFLTQEQSVKLAGENPDYATQDLFEAIEKGDFPSWTLHVQTMTAKQAQEFEHNILDLTKIWPHKDYPLREVGKLTLNENPQNYFAEIEQIAFSPSHLVSGIEPSPDPVLQSRLFSYPDTHRHRLGVNYAQLPVNAPLHLPSNFQRDGAMAFYNQGARPNYQSSIQPLSYKPRLYNTAEHEQFLGGAVQDLSVVTELDFVQPRALWQCVFDDSAKERFIHNVSGHMGGIKSESIRDGVLACFARVDEDLGARVAKALNVPAVAPLKVAPASEARRFRGSVNFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PPW6</accession>
    <name>A0A2X0PPW6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C054g12614 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">BQ5605_C061g12744 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C061g12744</name>
        <name evidence="1" type="synonym">BQ5605_C054g12614</name>
        <name evidence="1" type="ORF">BQ5605_C054G12614</name>
        <name evidence="2" type="ORF">BQ5605_C061G12744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000093">
        <property type="protein sequence ID" value="SGZ29327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000137">
        <property type="protein sequence ID" value="SGZ35483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PPW6"/>
    <dbReference type="STRING" id="796604.A0A2X0PPW6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ29327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ35483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="333" mass="38395" checksum="58B4CB457D95526E" modified="2018-09-12" version="1">MVVTAWIGKKARSFYWIVFCRLPTAQQPALETQPRRDIRRCRGDDEYDQRSRPQRKHIVAWYRHAINRLRFTPIAQPVAAVRINGPPRVRPRSEVRTTTPLESILPHPIDPPQRLPRPALPDQSTQYNLLSMDRPYTIRRVRRVLNAKAFTDTIGFRDSLQPDDLKGFWKGVNSKALTAREREVWFKLVRNFTPTRSLQFHQKHDDSPACLVCGAPKDDREHYFFDCVDSGNVWIAARSVLCDALGLDTIDNTHYTAVQLMFGLPKLKASLRDQEGAGRTIEIFTGLVLEMISSGRWGMQKWGTRMEGVGRRRIILEERLKLRAGGAWGRRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LT69</accession>
    <name>A0A2X0LT69_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Lon protease homolog</fullName>
            <ecNumber evidence="9">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C011g06392</name>
        <name evidence="13" type="ORF">BQ5605_C011G06392</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="9"/>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LT69"/>
    <dbReference type="STRING" id="796604.A0A2X0LT69"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19500">
        <property type="entry name" value="RecA-like_Lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000021">
        <property type="entry name" value="Lon protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054594">
        <property type="entry name" value="Lon_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="ATP DEPENDENT LON PROTEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22667">
        <property type="entry name" value="Lon_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="12">
        <location>
            <begin position="12"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="11">
        <location>
            <begin position="810"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="64"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="313"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="492"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="340"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="902"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="945"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGY12110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1021" mass="111298" checksum="85A42B566A1925AA" modified="2018-09-12" version="1">MALRSYNIPTHLPILPLPEKQVLYPSLVLSIQVVSKHSVALLQSVLREAEQNSGNKPLIIGVVPLKDTSSPTTGPPARPTPNPTSNRRDPYRTSPQSDDESDNQNKSNSAKSRAVVLHKNGVAARIVRLERLSSGGFIVVLEGLARIVLHMDDFGPSTLPFHETTVTVLKSTPLYSSSSLLESLQAIANQVLTSLSALAPLSLLLNRRLKSLIGSLTPETAPTLVDALIGSIPTNSTTGLLFSDRLAILSTLGGDDRVAQAIEILGRVDESLNLKKRIGDKVDQNTSRRQREYLLMQQLIAIRQELKELAANDVKNGRASSSPLSRLRGGPGDKKKSPVDDEDDDEENEENETAELEKKIKAKAWTEESRKVVIREFKRLKKSPPQGAEHGVIRNYVEWLLALPWNESTPLPLSRDFIEQARKKLDDDHYGLEKVKKRLLEWLAVLRLKQEQWEVDNAAAVASLEQAQLTDGTPARGFNEDAVDSTVGQVVASTNDSAPPPAAAPSVPAPSRQNVVAKPRNKGPILLLCGPPGTGKTSIAKSLASAMGRKFQRISLGGVRDEAEIRGHRRTYVAALPGAIAQALRKCGTNNPVILLDEIDKLVSSNTHGDPGAALLEVLDPEQNCSFEDHYLGIPLDLSSVLFIATANSLDTISEPLFDRMETIELSGYVVSVSHKACPGLVATLIERPFFIQHSEKLAIAKKYLIPKQVKANSLPADLLSMPDDVLLHLITSYTHEAGVRTLEREIGAVCRAKAVEYTKARDEAEAAKDPCGRLGAHVTKYGYRVDLTKEDIGDILGQSRHDAEEMDRENMVGVSTGLAYRGSGNGGVLHVETTSMPGHGNFKLTGQLGDVITESAGLALAWTKSHAHQLGIATSRTEDAFKDLDIHLHLPSGSIKKDGPSAGVAMVVAIVSLMREIRMIKGVAMTGEITLRGNVNPVGGIREKVLGAHRAGIRTLILPFKNRRDVKDDLPLEIQNDIEFIFVRNIFEALEAAFGKEALWRGREGDRIRDMVFSEMASRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LVY5</accession>
    <name>A0A2X0LVY5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C019g08820</name>
        <name evidence="8" type="ORF">BQ5605_C019G08820</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY22574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LVY5"/>
    <dbReference type="STRING" id="796604.A0A2X0LVY5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848:SF4">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="5"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="66"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="227"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="363"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="421"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="256"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="363"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="434"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="450"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY22574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="558" mass="60954" checksum="68B746FB72A4C566" modified="2018-09-12" version="1">MADAHMHQVMSNLWIGDYFASQDANLLEKHKIKLVVAAMRQPYDPLPGTTLHRVPVDDTASANIIEHFVPVSRAIASARLKSHAVLVHCQAGVSRSSALVAAYLMKEMDLTVEQALARVRKARAQIEPSDFFMLQLELFERCDCEWNPVKYAEERRFLMSFAQNEIMGGVSPSIVLAYYPSPTPSPIPSPKGSAQGTPLTMTPMPTTAEPSASDAYKFVGASPPVESSTSTSLSDRLGATTTPTHAPVARKRLTLRKAERETERQSAEMRKIPSIEKIGNKQEVVISGRRIRCKMCRFVPSAFLITFVIHGRVLIQMGLSLAWSIRRELAAREHVLAHEPGKGQQAFAPHRRDMAAHRMEMEARRRDEMDKEERERAIPNLETDTNIGTSVDKTEKSPATALAGLRISRPLPGLGARAVVQRPTVSRPRPPSAPESTVDGSTTSLTPMPESGEAPESSHSASASDAAKASEAEVKAREIFDSPILPSHLCSSYFTEPLSWMSPMLESGALGGKIVCPNAKCGAKLGSFDWAGAQCSCGTWICPGFALNVSRVDEIAEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LWU4</accession>
    <name>A0A2X0LWU4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C018g08730 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C018g08730</name>
        <name evidence="1" type="ORF">BQ5605_C018G08730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY26396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LWU4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY26396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="51" mass="5742" checksum="6C3C038D84E6296B" modified="2018-09-12" version="1">MNLIAGESPQIRAQLELIARTARKELLSLETSCQSVYCCFIPLLLPIMISY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LWZ9</accession>
    <name>A0A2X0LWZ9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C018g08780 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C018g08780</name>
        <name evidence="5" type="ORF">BQ5605_C018G08780</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY26768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="550"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY26768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1400" mass="153372" checksum="8D742CCBE684C43E" modified="2018-09-12" version="1">MSQPARGDSDDIGGMASTPPPPPSSSTSNQPFDVAPATVVTLTKEQYDALVKNQRPAQAQEDDAISMCHLLPPVNPPAFPHDSKLTEYNYVDWDLAMSTTYACKVCAYLRKGQHDPSWPPAFHTRWEDYAAQALASSLTVTTKATIGPLIQTGGSAHDCWLALAARYAPSDAQAYSTLIKDYFSMPPCPPTWSGFHAWTNRAMVLVNHVQMAQLDLEQAIAARALDDLPPVFNSWLTTFYAVKVQDNKLPCVEQIFASMETVARTLRHDPTPALAAKPVATTKPSASGKKGRWDRSGLAPSNCPACGQGKHWVDKCPDMRKRAKYFELRNAMKELQGTSSSQAPAFVATEEASKDLDMSFFSSPTFVSFGAPNVFLLDSVSACHVVNDASFFNGPLAPTLHILQGLGGTVKALGVGLVKLVSDIGTKFTLNDVIYAPESPANLVSVRAFDRKGVRITFERGQAELRTQQGRIATASAIASRVYKLNASVRTPSPGVIHTLVTTKSHGIPLLTLHRRYGHASVQTLKKLAASGQVEGLDWTYSDLDPSLFHASEPLALVHSDVLSFPEELFSHKRYLVTFVDDFSRKTWVYPIGHKSEVLQTFKDWLMEIENETGRKVKTLCSDNGGEYVSTAFNGFCGTLALLINSGLPCMCWDEAVMCYIHTKNLSPHPALKGGVPNCRWSGAPPPPPPPPPTVGALQAFGCRAWATVPAHGWDKLNPKGIPLVFVGYDRHAKAWRLLDPSSMRVSLSRNVTFLETEFPLVAVPARVTPPSVPGFYPRPPPADAPAMPLPPVLVEPTQPPSLNDDATSLIHLPQRPPEPTPLAKFKPTWEYGDVAKVGPNPGKYGEIDARNIIAGPRTRRQLVPTLITQEDLVGGPDGPTPAFQGMLRAFASTKAGFAEHNLSVVRDPANWGDVIQSGQQDTWGGPAHDKFDSLLNKYKVFKVIDSCELPAGEILLRSGWVFRTKCNQHGDIINRKARLVAHGCAQHPGIDFEQNYAPVVKFTSIWVLIALAAANGYHVHQADVNKAYLHGKLDKPLYMRVPQGIDMPGKILRLSKSIYGLCQAGTIWNAEIDSTLRSLGYVPTRLDICIYRREHNGHSHYIALYIDDLLLIGPSTAEIDRVLDALELAYGIKRLGPAKYILGIQVKRGHNGSITLSQERYLRDILARFQFANAKPAGVPMQPGVVLDFENSSATPEDRTRYLQAIGSLMYAAVGTRPDLAFVVSYLARFLQQPGPEHWTAIKHVLRYIKGTLDLGLTYRKTNQPLHGYSDANWGACLTTLRSTMGYAFILSGAAIAWCSKRKHRVAKSTTDAEYLSLSYASRDAIHLSELGAPVPGSVMLYGDNQGSLALAQHPTNHQGSRHVCISEHYVRKRVAEKEIEALGPKPFIFHQTNLGLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LXM8</accession>
    <name>A0A2X0LXM8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01076 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01076</name>
        <name evidence="2" type="ORF">BQ5605_C002G01076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY29694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LXM8"/>
    <dbReference type="STRING" id="796604.A0A2X0LXM8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018783">
        <property type="entry name" value="TF_ENY2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038212">
        <property type="entry name" value="TF_EnY2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12514">
        <property type="entry name" value="ENHANCER OF YELLOW 2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10163">
        <property type="entry name" value="EnY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY29694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="115" mass="13134" checksum="E3439FE48B17AE88" modified="2018-09-12" version="1">MSTLPTPSHPTPTEAQQLESALRDRLINSGEYDRLLILLKQRLDKTGWQDQVRGIAREQARSDNVKLLSLIDQVEPTAFGKLSFGIHAERWDAELSEVTQEMEKLMAEFVKKNVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LYQ0</accession>
    <name>A0A2X0LYQ0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C017g08445 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C017g08445</name>
        <name evidence="1" type="ORF">BQ5605_C017G08445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY20039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LYQ0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY20039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="55" mass="5881" checksum="620CB4E6F1D10D98" modified="2018-09-12" version="1">MSGALGSQRAVSVHKNVSIPRPFDLVMYQRPCTTPSLGPGHALANALATHYYSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZB9</accession>
    <name>A0A2X0LZB9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C016g08143 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C016g08143</name>
        <name evidence="2" type="ORF">BQ5605_C016G08143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY20784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LZB9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY20784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="109" mass="11964" checksum="6C43AA40CE72C0F8" modified="2018-09-12" version="1">MEDYDDNTNRPQKCEKRAKSTNPRFGFKCPSQAKAHPTATSHSVETFFFFLTGAHKLQSFGLAGTATKRAKGGYKATTASSWVKVKPLRAKSAAQIKTRRAPNADSNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZH6</accession>
    <name>A0A2X0LZH6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C016g08183 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C016g08183</name>
        <name evidence="2" type="ORF">BQ5605_C016G08183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY21011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LZH6"/>
    <dbReference type="STRING" id="796604.A0A2X0LZH6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF142">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY21011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="490" mass="52474" checksum="BB79135493B2DBA3" modified="2018-09-12" version="1">MANTNPVIGVVLLARHGDRAGFYQNPNTYAASNTSITPLGEQQLYQVGNMLRTIYADPSSDRAIQGLSNSTLNAAQINSTADGGGEGVCGDMVQLQQVALWQGFYPPNATVSSETLANGTNVTSPLNGYQTLQINTVLPADDVDFESWVNCETWANRTNEFYNSTVFLAKTAESAPFLKSLQTAGLVGGRNVPLVNAYNLYDFINVQRIHNATYSALLDTNGPYTLNAMRALADFHEYGSFTDSSDSGIGNIAGRTFLPRVLASFDQFANGTEVKIAHYQMSYKPFLSVFNMTDLSAAGFAGATAIVDYGSVATFELRKSMTNSTGFDVRFGFRNGSFDGTIPVSVPSSLVASFDFTYYPLFGSSSVDIPLASFETQLASSIIPNTTAWCHACSNTLNSGCATVALADKYEKLFQQSSSESHFSPVGAGFIGFAVTAVLGALILLLLARLGWVSFGSRQQRNRDLYPLRLGGPAKNVAGEDAGSVASSHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M0N7</accession>
    <name>A0A2X0M0N7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C019g08884 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C019g08884</name>
        <name evidence="3" type="ORF">BQ5605_C019G08884</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY23026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M0N7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039715">
        <property type="entry name" value="ZCCHC10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491">
        <property type="entry name" value="ZCCHC10 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491:SF0">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13917">
        <property type="entry name" value="zf-CCHC_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY23026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="115" mass="12567" checksum="5EB1CE037281AF1E" modified="2018-09-12" version="1">MFGNYLGIGNKGRPSGKRNSRPSKASPDTRCQKCEGLGHYTYECTGQRQYKERPTRTQQLKNPKLLTKSNGQAPPAEVDPRRSASAATLSAMIESSSTAVELPPKRNGGDDPRCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M0S4</accession>
    <name>A0A2X0M0S4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C018g08728 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C018g08728</name>
        <name evidence="3" type="ORF">BQ5605_C018G08728</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY26379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M0S4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY26379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="183" mass="20241" checksum="774DFFF8117F6889" modified="2018-09-12" version="1">MPSYLNVECLRLPAGITTLLAGLVTGFLLDALGFLADRLADLFDCIAHLLVLTDTLFHEAFGATLLRDDVTAPATETSALSRQEFLFYTDGEDVFALGPNLGDAGGGHAGYRTRSRGRKDCSKERQRIRRSDASTGRLAIEVIYHSVRLLEHRPYLFLESADKLFLDIASKCRACEEVSDRML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M1Q1</accession>
    <name>A0A2X0M1Q1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g02498 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C003g02498</name>
        <name evidence="1" type="ORF">BQ5605_C003G02498</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY41336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M1Q1"/>
    <dbReference type="STRING" id="796604.A0A2X0M1Q1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34071">
        <property type="entry name" value="5-NITROIMIDAZOLE ANTIBIOTICS RESISTANCE PROTEIN, NIMA-FAMILY-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34071:SF2">
        <property type="entry name" value="FLAVIN-NUCLEOTIDE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY41336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="265" mass="29678" checksum="1BF4D2CA252597D3" modified="2018-09-12" version="1">MLNEETHFEKTKLNTVNHPLSYFLLSSLTRHRYAKRGHYDKRLIFAIVRAVPVVHVAFVDRDGLPQCVPMVAAIEETEDDEVFVYLHGSSVTRIMKNNGEGEPLCITATLVDAFVMSLTPFHHSVRYRSAVLHGTTFPFSESYDGDVEAAKVHALHVTTNAICSQRWENTRSSPTSAEMKATGVIRLRVESASAKVNETGPNDEAKDLNNEELVTKTWTGILPFKMVAGDPQPSSYSCKEVPSHIRDFQAEFEAKDRAAFPEPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M451</accession>
    <name>A0A2X0M451_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C001g00703 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C001g00703</name>
        <name evidence="1" type="ORF">BQ5605_C001G00703</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY48842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M451"/>
    <dbReference type="STRING" id="796604.A0A2X0M451"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY48842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="409" mass="46915" checksum="E659C6541AD430A9" modified="2018-09-12" version="1">MYDLPYAAKCSIINIYCYTKILYYSRFLPAPKSVVKEIEEAAMLAIHGRASDGTQRRPKVSRSRLCTPLDHGGFGLIDLPRRLAIDHAKWVFQLRAPDGCFTRHLFDIRIRLQAPNEPTPFTLSRPAPNQHRCPWIWIWWAYFCHPPPKWDHAVRKTTKLLPARWVRYFEAWASVTTLNPPELSKSQNLEQWATHVLYLPAGHGIQLSVNPTLFRGPDGEVMTPSSFVNASKRHQVFIFPPIFPKGHQKVFDLPEQRWNAWWKALRKVCRVHLDAEDTGHLLSLGSLHPGSQVASPTSPHPNNRSTSCVMCLSEAPECLVHLAVGCPFARRLWSALSPTPHPVFVDFVCPVVSRSERRLVELRVLFFHSIWKLCRRRRFSSDLLEPITETEFEGLRASIQESKGRLVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M4X6</accession>
    <name>A0A2X0M4X6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="21">BQ5605_C001g00970 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">BQ5605_C001g00970</name>
        <name evidence="21" type="ORF">BQ5605_C001G00970</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY51143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="11" id="KW-0229">DNA integration</keyword>
    <keyword evidence="15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="12" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="16" id="KW-0862">Zinc</keyword>
    <keyword evidence="16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="19">
        <location>
            <begin position="422"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="20">
        <location>
            <begin position="1579"/>
            <end position="1751"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="18">
        <location>
            <begin position="1894"/>
            <end position="1955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="483"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1292"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="484"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
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            <begin position="512"/>
            <end position="522"/>
        </location>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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    <evidence type="ECO:0000259" key="18">
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SGY51143.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1957" mass="217362" checksum="79DD651007049BA0" modified="2018-09-12" version="1">MAEPTDTSRDTTAPVREDPSRANPPKSPPTHSPHPLQAAAVITSLESRLAESEALRRDSETRICKLEQMVERLMRESTAPAGAQVGEALPVRPVPLDVPPHTFLGRPGAAADPLARTPGGESHSGIRDGPSSAVISSRWRGTLPDREGLWTGDHPERLVIFTAFGESYLSLLCDISTSDLFDTSRVIQLVATLFSRTTTRQRRQSPLDWAVEAMRDALGEGRPHCWTSLMKAVGRRWPDPGFADRVAQDFHGCRQSSSRAYDHVGEWRARYRAFVHDNDSFTLSPLQLATTFYQSLSDSSKREVRAGMLREYHDNSLVTIGRFGLKVPSIDEITEWAAIADDISPPPSVPTPPSRTATYGAIVKAPRVSPPATNTPTVDERFQIRRARWVDRATKWQQSHLWKDRSTWFSPAPSGVPTSMACFNCGRGGHFSQHCTAERQSPVAVQLSAVAVADLDDEDWSSVAGGDEDPEVRVPISLERVQTRPLSSVSASMTRPSCPPADPVGRMKEGASSSVDVEVSSSNPQPTAPASDADLRRLADDSTDSAFDAVEDVPSYADAASRMRRYWGPEVVSSRKAERTASVSSVRVPVPLGVSLLESDTPLIDVDDFARPAEPAIVRARNIIAWTLPSGRTLRCLVDSGSEVDLVDQDVVRTDPSFTMSRLTAPLHLRLGTRDKSDRCAVFANALFTSGSLDLGLRAFFICRVTAYDAILGLPFLKDTGMLVGWGVFTVARPGPSQPVAKGTHEWDRAVTVAPICSGSAIGYDHPGLLPDDEIIGLEPHNPLLDVVDDPALEDLSESEARTRLAALLEKYSDVFVDSLPMDRLPPYRPVNHEIPLIDPNEKVKPRVYPLADKYRSQWAEHSAKYTRGRFWVSGPIDSAAPVFAIPKKNSQTARFVIDLRARNSNTAKRFSPIPDMTSVRYEVARSRYRSKFDVAAAFEQVRVIPEHVDRTGFATVTGTYTSRVMQFGDTNAPNTLNLLTSAMFQPCLSFAKIFFDDVHVHSDTRRAHLRHIEILLMTLRHYRFYLGSNKSEWFSKSLDSLGAIISDDGIEVDPAKWERIRQWPTPHNKTDVQRFLGTVNWMRDHLPHLSITLEPITALLAQSTSWRWNEHEQQAFDTVKSLVPATLRPIDGAKVTSGEHKIYLFTDASRVGIGACLASGPTRSQAVPTRFFSAKFNGAQLNYHVTDKEFLAVVSACRAFEQHLIGYPFVIVTDHQALRTIKTQKLRQTPRHIRMCLELSRFDFEFEFIAGKNNSLADSLSRLWEVKEGSPEDQVKENELEDMFFDGERHGFTTHGESLPEERPYTSPSPDRLPPVDFAFGPQRDDCEAGSPGYYALKDESQDEDVNGRDLGNLFLKEECHEFTTPGSPGSHRLAENIMDTVDSSTGPLSPPIAVNRVQAIAAAPANDAPIPVDADADELDLLGAAADEVNDAPVVHRPPDPLPQPFLDAVIRAYAHDSQAQVIVDDPLSWPMFRVTEEGRILRVHPDESLSLFVPRGLATGVVDSDKVPSLRELVLAEIHRSVGHAGHRITLAAIRPLYWWSSMSADCAKFCHSCEDCARGKASTQVPYGRLHPMPIPSGPWEQVAIDFMTGLPPVEFEGMMVAQIMVVTDTWGKMVHLIPLPADADSELVADRYYATIFRLHGTPSAIVSDRDPKFTSQFWRALQAKVGTVLRMSTAAHPETDGSSENRIKMVTQTLRIMVSSNHEAWASRLVEAEFALNSSVAVSTSLSAFEATYGYLPRRWPTDSWSVSDVPRAEAFARIRQLRNLDVTDAIIGARLDQTHQANKHRRPDDPAFRTGSYVYLSTKNLAVPEGMKSKLLPRYIGPFRIRAAIPATSSYDLELPPAMSRVHSRFHARLLRPYVENDAERFPGRDPAVLFVEDVADAADNSAIPERIVRDRRNARGNRSFLVRWIGRKDIDDTWMSEQSLRFDHPSLLDTYLAQLDRSNRRLSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M521</accession>
    <name>A0A2X0M521_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g02213 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C003g02213</name>
        <name evidence="1" type="ORF">BQ5605_C003G02213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M521"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY39406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="133" mass="15057" checksum="9DED2AB515CECF07" modified="2018-09-12" version="1">MSVEQLADSVCVLFCGAEANSTELDKCRPIIVRQGKVKRMLEWLSHVCGFSREHLPPERQQPQHLIREIGLELVTSEALATQGMEFKLRCLFSEHVATAWNLENGQSIEVNMPNLTAKPQVVFTHHQLIIPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M5U3</accession>
    <name>A0A2X0M5U3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g04059 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g04059</name>
        <name evidence="1" type="ORF">BQ5605_C006G04059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY55670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M5U3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY55670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="83" mass="9107" checksum="1E0D8CDD65C86863" modified="2018-09-12" version="1">MSIGKKVEYFRDRAKLTPKNSQVDHINDIVLDLLPGDAQTFYSADSDTFVAVDVAAQSPIALRLLPENQLRPMDPPPVNAAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M8M4</accession>
    <name>A0A2X0M8M4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-aminobutyrate aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GABA aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Gamma-amino-N-butyrate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C001g00907</name>
        <name evidence="13" type="ORF">BQ5605_C001G00907</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23352"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="2.6.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.19" evidence="3"/>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY50613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M8M4"/>
    <dbReference type="STRING" id="796604.A0A2X0M8M4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034386">
        <property type="term" value="F:4-aminobutyrate:2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000073">
        <property type="entry name" value="Probable 4-aminobutyrate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004631">
        <property type="entry name" value="4NH2But_aminotransferase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00699">
        <property type="entry name" value="GABAtrns_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206:SF1">
        <property type="entry name" value="4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="25"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGY50613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="516" mass="56336" checksum="ADCB868CE63A5437" modified="2018-09-12" version="1">MLSPTILPRSTGLCLRAVASRSISVRPSSSSWGGDAGPRRSLATASSSFFPDEPKAPTINTAIPGPKSKQASEAIAQFQDPRTHVFVTDYAKSKGNYIADVDGNVMLDVFAQIASIPIGYNNPRLLELAKSDEFAIAAMNRPALGSFPSKEWAETINSGLLSVAPSGTPHLFTQMCGSCANEGALKAAFMAYRARQRGEEQAFSAEEMSSCMKNEAPGAPQLTAMSFTTAFHGRLFGSLSLTRSKAIHKLDIPAFDWPAVPFPLLKYPLSEYASDNAETEARALAQVEATIVEQKKIGRDVAALIVEPIQAEGGDNHASPGFFNALRTLTKEHGVYMIVDEVQTGVGATGSFWAHEKWNLDTPPDFVTFSKKMQAAGFYHRAELRASLPYRNYNTWMGDPIRALQAREMISYINEHDLVAHTESIGNALYASLLSRAKSNHSQHIQNLRGEHAGTFIAWDLETAAKRDKLVVEMRQRGINMGACGDRAVRLRPMLVFGQPQMEVLLGTLDEVLKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M9H0</accession>
    <name>A0A2X0M9H0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C004g02983 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C004g02983</name>
        <name evidence="5" type="ORF">BQ5605_C004G02983</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY69268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M9H0"/>
    <dbReference type="STRING" id="796604.A0A2X0M9H0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF24">
        <property type="entry name" value="RLPA-LIKE PROTEIN DOUBLE-PSI BETA-BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016057368" evidence="3">
        <location>
            <begin position="26"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="RlpA-like protein double-psi beta-barrel" evidence="4">
        <location>
            <begin position="269"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY69268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="324" mass="33594" checksum="B59F486415F58C7A" modified="2018-09-12" version="1">MPSLQSLAAFTLTLSLLLQPPLLSAHPSPSSDFIDPRIINRDLRTYGSTSGSASRTRPRSLHKMNRRNRAPKSGPKRLNRATEATLKCLTAYSFALCDGDSCTDMGSVAAGTKCVDNAITWDDATAAATSSAAKARTSPEPTPTIAPVHLAVKQPTTPAPAAPTPGSSSDDDDDDACDSDDDSDDDQEITTTAASKPTTAAAASKTGASSVNLNAITSTYTTGGKGTFFYQYGAYGACGKIHADSEPIVALALARYGTGSNDAPDCGRKVQVVNVANGKSVVATVADACPGCANYNSLDLSTGAFDQIAEQATGVIDIKWKYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MA38</accession>
    <name>A0A2X0MA38_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C005g03225 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C005g03225</name>
        <name evidence="2" type="ORF">BQ5605_C005G03225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY72888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MA38"/>
    <dbReference type="STRING" id="796604.A0A2X0MA38"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY72888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="210" mass="22506" checksum="51CE2010C933830E" modified="2018-09-12" version="1">MSYMLPPSAYPRLDPPLLTRLPRPPRVANPYAQPASKRFADTLYPTLQDKLDQLDYLEEQHLSSMHEIRSFGFSWLVPLGRQNTQEEDLESTYSNSPPPGSPPLISDTDGALATGAQIDEVMADVAEVDLDAEIEDADQAASSASEDDVEDEEAGANADLEPRRQGGENQGASPARSGSPGLDSPFASSPEVSTDAGEGEGDLSEVSMDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MAM1</accession>
    <name>A0A2X0MAM1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C005g03372 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C005g03372</name>
        <name evidence="2" type="ORF">BQ5605_C005G03372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY74597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MAM1"/>
    <dbReference type="STRING" id="796604.A0A2X0MAM1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF4">
        <property type="entry name" value="ENOYL-COA HYDRATASE_ISOMERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G01890)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY74597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="301" mass="32733" checksum="0C13978BBAD84101" modified="2018-09-12" version="1">MSLYPELKDIRVELREHGVAVVYLDRPTARNAFTDPMAKSLVVAFDRLDSDDNVKVVILAGSPNEGKAFCAGADLSKGDFSTSDRYSQNSARNLNEHRDGGGTVSLALFRVRKPTIAAVNGHAIGIGITMTLGADIRLVSETAKIGFVFAQRGIVPEAASSYFLPKLIGHSRAMQLFMTAKVIPATSPILDLLWASRHPSPEATFQAALVLAKDISLSNSMISSSLIKGLVWRGMDSPEDQHLLDSKAMHVAGNSIDSKEGVQAFRDKRAPRMVATVPKDLPTEFYPWWSQKIITRAGAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MCC3</accession>
    <name>A0A2X0MCC3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C004g02869 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C004g02869</name>
        <name evidence="1" type="ORF">BQ5605_C004G02869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY68248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MCC3"/>
    <dbReference type="STRING" id="796604.A0A2X0MCC3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061671">
        <property type="term" value="C:Cbp3p-Cbp6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037653">
        <property type="entry name" value="Cbp6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28250">
        <property type="entry name" value="CYTOCHROME B PRE-MRNA-PROCESSING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28250:SF1">
        <property type="entry name" value="CYTOCHROME B PRE-MRNA-PROCESSING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20180">
        <property type="entry name" value="UQCC2_CBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY68248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="122" mass="13840" checksum="4E8B9EE26C95AB00" modified="2018-09-12" version="1">MSMSSTTLRTSLHSLARRWPKDPLRPTLQFSDSLQAAVDRVFATPPAAAELGQKQILKAQEMHDSLTRLLANDALKSYPMTQKTLKPASFPKHYARMQDGIARASRGEVVKGQSWLEWFKWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MDX3</accession>
    <name>A0A2X0MDX3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C009g05787 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C009g05787</name>
        <name evidence="2" type="ORF">BQ5605_C009G05787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY85905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MDX3"/>
    <dbReference type="STRING" id="796604.A0A2X0MDX3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY85905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="273" mass="28931" checksum="C22AB97F0E8A74B1" modified="2018-09-12" version="1">MASSTSSTHQAFVDHLVARIHSDMDFLCSQGLLNAQDVEVIKAKLPSGLHGVGSGGVERLNGQLGGLDLNTHPSERAQAGQGGGSTDRATCRAVWDYQASQVSPAHICSRLPCPLTDDLSSSQPDDLPFTKGQIIVLESELNQDWWQGSIAPYYNHQPPPPQTQAQQYAYQQPQPYAASYAPSGSNSYPSGPSHYAPPNNPYLDDKQHYTPPPPPQQIYQPPPPPPTAAPTQAMGTATPQPPPMPKKRFGKVGGQLGSAFVGGLGFGTGSAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0ME90</accession>
    <name>A0A2X0ME90_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Actin-related protein 2/3 complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C012g07037</name>
        <name evidence="10" type="ORF">BQ5605_C012G07037</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
            <location evidence="7">Cytoskeleton</location>
            <location evidence="7">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the WD repeat ARPC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0ME90"/>
    <dbReference type="STRING" id="796604.A0A2X0ME90"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017383">
        <property type="entry name" value="ARPC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709:SF2">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038093">
        <property type="entry name" value="ARP2/3_su1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="52"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="9">
        <location>
            <begin position="107"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY16942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="411" mass="43886" checksum="2C4997CBDA9E84EC" modified="2018-09-12" version="1">MSLAQVEVLVPGTPITAHAFNADRTQLAISANSNQVRIYAQGNKGWQLTSTLSEHDKLVTSIDWAPHSNRIVTCSHDRNAYVYTNTHGAWTPTLVVLRLNRSATCVRWSPTEDKFAVASGARSIAICHYDQESDWWVAKHIKKPLRTTVLSLEWHPNSVLLAAGSADGVARVFSAWMKGIDSKPEPSVWGERLPFNTVCGEFASPAGGWVHGVAFSPSGDALAFVCKHRLGPTAHDSTLTVVYPTGADQTPRAVYAVQLASLPLLSLVFTSEGSIVAAGHDCEPMLFEGSVDGGWAQTRSLDDPDKRSGGSAVAARSGRLAQSEAFNVFRQADSRGVSSSAAAGSVASPGTRLTATGTELLTVHQNTITSVRKYDYEGAMVSTTGVDGRLALWNVHGEVGSVTRAMGRMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MED0</accession>
    <name>A0A2X0MED0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C009g05764 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C009g05764</name>
        <name evidence="5" type="ORF">BQ5605_C009G05764</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY85573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MED0"/>
    <dbReference type="STRING" id="796604.A0A2X0MED0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="entry name" value="paralog of FGE (formylglycine-generating enzyme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051128">
        <property type="entry name" value="EgtD_Methyltrsf_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019257">
        <property type="entry name" value="MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397:SF2">
        <property type="entry name" value="HISTIDINE-SPECIFIC METHYLTRANSFERASE SAM-DEPENDENT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10017">
        <property type="entry name" value="Methyltransf_33"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine-specific methyltransferase SAM-dependent" evidence="4">
        <location>
            <begin position="26"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine-specific methyltransferase SAM-dependent" evidence="4">
        <location>
            <begin position="173"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine-specific methyltransferase SAM-dependent" evidence="4">
        <location>
            <begin position="405"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase-modifying factor enzyme-like" evidence="3">
        <location>
            <begin position="747"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY85573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="966" mass="107073" checksum="A9098F050E9F5251" modified="2018-09-12" version="1">MASALPPPAAARILPLKSAQQPSHLREQLIDGLTASRRQGQDDRVWSRSIPTQYLYSDAGLGIYSEIIARCKSYYLFACELEILQNYGDEIAARMLGLPSDFALAKNQSKKSSELNTHNHDMDHAEAEQAPPLQTNGEPKGSPIREKWGDFGVGKHNHGVNGCSGEVNGAPSAEAVIIELGSGSLDKTRHLLSAFSELLKAGKLSGFRSIDYEALDLEKSSLELSLNSLAEQEPAAVKTEDDETPRVKIGGLHGLYDDGIDHLARYSSSQDHARTSSIMWLGSSIGNFSRREACLFLKNVKLRPGETMLIGIDGCDDAATIESAYNDPEGVTRRFILEGVDQAGRALATNTAKGDYPNGSPLCSANFEYENWYNQKEGRHEVSAALNPWVEDGLGPFNRLPFLKAYIRCRVDKLRVPIPGREDVVLEKDELMQIEVSYKYNRNEALALFHAAGMRVVQRWSDSTQKYSLYLVERPTIAFSLSNHPSLQQFGVTPSPNAYGLPSVDEWKTQWASWDMLVRDIMPQDLLMTKPIPLRHIPLFYLGHLPCFTAIHLSRYFKEPLVEPAAFVSRGFLPLATWCHDLTYLVPTLQADLFERGIDPNVETKAITHWHSAAPQNDQWPSLDAITEYQDRVRARVLRIYEEEFKDGRMTRRLARILMMVFEHEAMHFETLVYIALQAAQQLRAPIGAQVPDFVSLGRAWAREAAADDAESLTKPLEFGSCTVLIGLDDNEDEDGNETHKFESSHAFGWDLEAPKREVQVAAFKLSALPVRNKEYLVFLSTVESTDALFPSSWRSLTGSATSSVDDIVVKTLYGEVAMTHALEWPVTGSAVQLAAYAKANGGRLPTREELAVFHAANPVDAPTSNIGLVNLHPLPPSPSRPGSRLPGASDGGVWLWTSTKLDAHEGFVAGKLYPGYSTDFFDGQHLIITGASYVTPARLARPSFTNFYQAKYPYVLCGARIAFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MEJ6</accession>
    <name>A0A2X0MEJ6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="28">BQ5605_C038g11659 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="28" type="primary">BQ5605_C038g11659</name>
        <name evidence="28" type="ORF">BQ5605_C038G11659</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000061">
        <property type="protein sequence ID" value="SGY91336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0229">DNA integration</keyword>
    <keyword evidence="20" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="18" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="21" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="17" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="18" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="19" id="KW-0917">Virion maturation</keyword>
    <keyword evidence="24" id="KW-0862">Zinc</keyword>
    <keyword evidence="24" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="26">
        <location>
            <begin position="298"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="27">
        <location>
            <begin position="501"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="27">
        <location>
            <begin position="1552"/>
            <end position="1728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="758"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="815"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="870"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1473"/>
            <end position="1504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1834"/>
            <end position="1938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="762"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="815"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="832"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="1888"/>
            <end position="1904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="1925"/>
            <end position="1936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="SGY91336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2506" mass="274275" checksum="591797B4D860EDEA" modified="2018-09-12" version="1">MDSSPNTPSPHRDSSPLASSISDQIATLQAQLAALQASQPPAAAASQPTAAAVVANPATVATASKVVFPKHARLDGPKSFTNWLRQLRLALPNQLRAYVLDGVAPATWTADQLAARDDTAREIIVGSIDSADVSATLDAIPSDDLSAPRIFAALKARFAPDDATRTLELFARLWDFRKMPASVDAYDTWLREYMSIAQEIRDAKTSLNDVLATHVLAMVPSCLDSFRLTFTDEQRNQRDLPELTTLTDRIRIQLRSAGLSTSHSAMIATTSPCPACHAPGHRLRDCTSRAQYPPAGPCRRCNKKGHWALDCKPRGGQQQTGDDNQSGMPSSAVHQPNVGYFASGLFARRQLPTDAFVVDSGATTHMVADRSLFTAYRQTAHTKIGGIAGGITAIGMGDVAFVAKTGHPITLRGVLHTPGLHVNLLSVSRLCDTDRVRLAFTSDGIDIAKDGQAIAHGTRKMIAAGLLHGFGAGYSDKDVEEFVCNACLGSKGHRLPFPDSESHSPERLGLVHSDVLSFPTPSLTGKRYLVTFLDDHSRKLWAYAIDHKSDVFPTFQTWLAEVELQTDARLRILRTDNGGEYRSNAFTEFCKSRGIRRQYSIPYTPQQNGRAERVNLSIVEGVLALLADSHLPATFWDEAAAYFVYCKNRCSHSALAKQTPELAWDGQRTTATALHPFGCAAWLTVAPDLRSKLDPKATRVIFTGYDLASKAFRFFDHSANKIVLGRNATFLDDDFPGLPANTPVDADNTEREFTIPADTCVPTSTPAPASTPAPAVKTRTPLVRSAHMDVSSSIDDSTMSAVDVAPGYTGGSLLNSTDTSLSSSPSLPPFSSPATSSAGGPSIDDSDDPLDLLNSNTAVRLNLMDVHRSDDDTLVTPTPAVASAGQPSDDDSPDEIDFLSRHHRAFIATDDDDPALEAIEPVKSITSDPQTWREAMSSDEHDLWAQAAADEFTAMRDDFKVFTIEPRSSVPPGATIVTSKFVWKTKRNARGDITGRKARLVAQGNRQRDGIDFSETFAPVARFSSIRCLLALAAAYGYHVHQADIDKAYLHGELDHDIWMTTPRGFDFPSDKVLRLRRSIYGLKQAGRIWNRHIDTSLRSLGYRATGTDHCIYSRIDDQQQTHYIALYVDDLLIVSPALDEIERVISGLERRYGVKRLGPAEYILGIQIRRLEDGSIALSQERYIMDVLARFHFDTTTRGATVPMTPGLSLTAVPGQGTERIRSWYLQAIGSLLYISLGTRPDIAFAVSYLSRFANNPGRRHWIAVKHVLRYLRATYRDELLYASGSPKITGVVGYSDANWGACVDTSISTMGFVFYLAGSAVSWSSKRQTRVADSTTDAKYLALSHAGKEAIYLTQLLSELHVRPIEAAHIFTDNEAAAAVAHDPVRTSGTRHIRLREHFVRDMVNRGDISLSHVGTANMVADVFTKALGPKIFGTHCYALGLRTRHPRIKSTSHSRGGGCEESTLRSVQDLGARSEPGASRTDLCARSEPGASARDLGARSEPGEMARDLGARNEPGLLVQSGLVTGVDWVYKDQELRDFYCNACLASKAHALPFARSKSIASGRLDLLHVDVAQMPRPTFGGHRYMLVIIDDFSRKHWCILLALKSDVFPRLRDWILEVENATGNKVKTIRSDNGGEFTLRNFVDFCASKGIRRELTLPYTPQQNGRVERSNRTIKEGILALLYSSGADSRLWGEAALYYVHCKNLMPHAGIGGEIPDTRWHGFAPDISTLRAFGCRAWHHLPSAKRTDLDPKAVPLLFVGFDQHAKAFRLFEPSTRRIQLSRNVVFRESEFPALRPATDVRAEPIPLPVTVDAYPDQVDPLEPSLVASPRSLAPRAEPPRPVPAAPDQGPHRRAPAREVPDQDSLAPPAPDQGSPARELPDPESPASSASDQGSSDSAISTPCPSPRPVASRALPAPPSPARSDSPDPIDLLPRPRDVASLCQAQEFPNDVDDALHSPSAVAYLASGAAALIETSPADPAELIAPARDPPHWRAAMATPQADEWRLAARDEFDSLLRDFSAFTPIDESLVPADAKVLGSRFVFRTKRDQHGQVKSYKGRLVARGDSQRSGIDFDETFAPVAKFTSIRALLALAAAHGYHVHQADIDKAYLHGKLDAPLYIRVPDGIYMPGKVLQLHRSLYGLRQAGRIWNDEIDSALSALGYVATESDHCVYVRTTGDVHHYIALYVDDLLMISPSLPEIERTLQGLEQRYGVKRLGEAEYVLGIQIRRSPDGSISLSQEQYLKDVLARFGMSDAHPVATPMQPDLRLEVELQPTPFPDRTRYLQAIGSLMYASTGTRPDLAYTVGYLARFSHSPSTAAWGAVKHAFRYLAGTLSHGLRYARGNPAPLLGYSDCNWGACVLSSKSTMGYTFVYAGAAVSWSSRLQSRVADSTCDAEYLALSHAGKEAIFLRQLFGELGLSSSKPVLIYGDNQGANALTKNPVFHARTRHIRLREHFVRDMVSMGDIVVQYINTGEMTADIFTKALSRDLFARHRGRLGICAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MEM4</accession>
    <name>A0A2X0MEM4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">26S proteasome regulatory subunit RPN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C005g03359</name>
        <name evidence="9" type="ORF">BQ5605_C005G03359</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4 5">Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proteasome subunit S2 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY74368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MEM4"/>
    <dbReference type="STRING" id="796604.A0A2X0MEM4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000026">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016643">
        <property type="entry name" value="26S_Psome_Rpn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041433">
        <property type="entry name" value="RPN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040892">
        <property type="entry name" value="RPN1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18051">
        <property type="entry name" value="RPN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17781">
        <property type="entry name" value="RPN1_RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015965">
        <property type="entry name" value="26S_Psome_Rpn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RPN1 N-terminal" evidence="7">
        <location>
            <begin position="69"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit RPN1 C-terminal" evidence="8">
        <location>
            <begin position="873"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00057191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR015965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY74368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="936" mass="102843" checksum="A59978BAFBDA2083" modified="2018-09-12" version="1">MPAAEDERDPNGVPFIVAPIPSKDPVKKDDKGKSPEGDDDKKDPTTTATAAKEDENELSEEDAALKSELEMLVERLKATDTSLYRPALESLRTLIRTSTSSLTSVPKPLKHLRPHYADLAAIQASWPDQPSTSMLDDVKKAVGITSADSSTASVSDKSLFADILSVLAMTYSDSGKRETLSYRLKGGSEEDLGLWGHEYVRHLAAELGEEYLARQNDESSTESTDDLLQLGLRLVPFLLTHNGEADAVDLLLELESIPSIVPHVDKDTYARVCLYMVSCVNLLISPDDQLFLKTAREIYRKHGKYTESIALSLKLQDMDLIKEDFESPTNPHMKRQLAYLLARQQVNIETDDEDLVEILNNTKLTENFKRFGKELNVTEPKSLEDIYKSHLENTSRSGAAASVDSARQNLAGTFVNAFVNAGFGNDKLMVEAEEGQSWIYKNKDHGMFSAAASLGVSLLWDTDVGLSQIDKYAYATEEHIKAGAMLANGLIHSGIRTEMDAALALLSEHVESKSVPLRVAAIVGIGIAYAGTQREDIRELLLPAIADSAVTMEIAAMTSLALGFIFVGSCDGEVTMAILQTMMEREEAELKSKWGRFLGLGLALLYLSRQDASDATIETLKAIEAPIGKQTLVLVEILSYAGTGNVLKIQSMLNHCYEHIDAEKEEDLHQAFAVLGIAVISMGEDVGSEMAIRQLNHLMHYGEPVIRRAVPLALGLISASNPVLTLLDTLSRYSHDNDLAVSINAIFAMGLVGAGTNNARLAQMLRQLASYYAKEPDCLFMVRIAQGLVHMGKGTIGINPFHTDRTLMSPVAVAGLLATIIAFTDSKEFILDKSHWMLYFIVMAMYPRFLITFNEEGEFLPATVRVGTAVDVVGQAGKPRTISGFQTHQTPVRLGQIERAELATEEYISYSHVLEGYVILRKNEGYEKEDVPMDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MFS6</accession>
    <name>A0A2X0MFS6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DIS3-like exonuclease 2</fullName>
            <ecNumber evidence="5">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C014g07637</name>
        <name evidence="8" type="ORF">BQ5605_C014G07637</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RNR ribonuclease family. DIS3L2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="5"/>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY19403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MFS6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990074">
        <property type="term" value="P:polyuridylation-dependent mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.690:FF:000001">
        <property type="entry name" value="Cell wall biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000002">
        <property type="entry name" value="Cell wall biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03045">
        <property type="entry name" value="DIS3L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028591">
        <property type="entry name" value="DIS3L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041093">
        <property type="entry name" value="Dis3l2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF9">
        <property type="entry name" value="DIS3-LIKE EXONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17877">
        <property type="entry name" value="Dis3l2_C_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNB" evidence="7">
        <location>
            <begin position="892"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="337"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="397"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="650"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="732"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1380"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="424"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="440"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="487"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="741"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="755"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1380"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1394"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="904"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="913"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="5">
        <location>
            <position position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY19403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1476" mass="160550" checksum="82235AD33F4DCEF2" modified="2018-09-12" version="1">MTEESVTPPPTNTQKKTGSATPKQTTPSTSSSSPNVAANKGAGSAPHSRKGSRSNAEKQSGRASNNGQANASQGVASTKNIISKLQDSPSSEFSSPQASVTNRSGHQLQPRSNSNSPARQRQQAGGGGGPHRKNQASSTTPPASAPMIQTLSSSLNPQAGGFQPNLLGPIHDSLDESLVTPTATHFDLMEGVPRSAAAIARATKTGSGAGAGAAAAAPRQYADFSAMGAIGPGAEFVGGFAAAQSLGAGGNGARVGGFGFSFPPATSTQQQYAQMQAAQLQGPFGQQTAQQQAATGVASQASELLSEQLAIQQQLTNLRIQQEQLLARFGDMQQQQLQAASGVEPTQPVPVNIATSNPPPSHRRGQSAFSSFGSGGGASSFGQMGSFNAGPIVGSASAASGNSSAAGLPKGHGRRHSVNTKALQQQQHQQPTGQPDQQTLSSSFQFPNHAQDGNHNSMNDRNQQRLDFNTSNDQASAGRACGHQRRQSGSMSSLGGWQASFTGPGQHQANLAEASAHLQQLAAYRASAGHARVPSFGMSTLGQGPGQLAMASYGGGLPPPGQHNQQGNQARKTLFAPYLPQASIPPLVQAGKLVIGTLRVNKRNRSDAYVATDTLDSDIYICGSKDRNRALEGDLVAVELLDVDEVWGTKKDKEEKKRKKEENASYDPRATRDLRKIDKKKDDVEVEGQGMLLFEDEEVNDDQKPQYAGHIVAVVERAPGQLFSGMLGVLRPSSAATQQKQESERREREGVDLRSGNNNSTPSSGNASQQQPYGGGGNHVPAPRIIWFRPTDKRVPLIAIPTDQAPEDFIECPDKYASRLFLGSIKRWPKSSLHPFGGLVEELGEIGDIEAETNALLKNCNFSNDDFSDAVVKCLPPIRWSIPEREQQPEVRRDFRDQRVFTIDPETAKDLDDALHVVELEDGTFEVGVHIADVSHFVRPNTALDREVRKRGTTVYLVQRAVPLLPPTLSEELCSLNPRSDKLTFSVVWKMTREGKVLSTWFGKTLINSRAKLAYSDVQEVLEGRDLVQGKFETEQERLEAIEDIKRFNMIARNLKKERFENGALRIDNVKVSFKLDEDGQPEDCDHYVRKEANELIEEFMLLANMSVARKIATALPDQALLRRHEPPIDRRLDGFIERMGRLGIKLDGSGPGALMNSFNQVTDEASRTTLQHLSKRSMQQAKYFCTGTLDISKYSHYALNVPLYTHFTSPIRRYADVIVHRQLEAILGHQAAQEAAHEAQQVSVGEPKFSLDVEAVSKIASMCNIKKMNAKLAQEQSQHLMLCVLVHDLTKRYGPVIRPAVVIGVLDQAFDVLVVEFGIEKRVHVDQMPTESTQYDEHDNSLSIYWKKNVEVLGWLAEKNNDEHLLRIRDQAEFHARGLGNHADKKSKAESALFDDDEDDEEPADGQRKQPLRMTGQRLKSLNRMPLKFEGLSDRDQHCIQTVRELQTVPVVITSDMTKSPPVIKVHAINPSCSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MFY7</accession>
    <name>A0A2X0MFY7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C005g03670 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C005g03670</name>
        <name evidence="2" type="ORF">BQ5605_C005G03670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MFY7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY77566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="392" mass="44169" checksum="783B30ECB8BCC1FA" modified="2018-09-12" version="1">MKEVFFLYISWTLKLPTAIFRKEAAALTRLRLRAKITVKHGHDCLGNALEVVPDALLSRETNLSSALVSLVGKIDGNRHHRRLYHIPTCKAATDRAKYNEPKRGRLFRNAIIRHLEEIIAATARRIQVVVPSDKSTPVTHPVPFITNETLAACVHGRSSKEWEVAFCHVVSFVFPQPPYLGPSKMKHFDTLSFDEDVIVPPMTKFSSETTNSTTSEAKITEISSDSTADDYGKRSNTSDVWYVVLFHVEWSRKSRELEMTLARMSNQLAPSTLSFGVVTPESTPPIFYDLDLSTSVTSSFQDLPLIALYHRGELVDRLPKNAQKIALERKERREEMRRQGWSSKSLREGQRRRERKKITEGADAGDGDEGSESGSGTDESEDEREVQIIAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MGS6</accession>
    <name>A0A2X0MGS6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C008g05270 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C008g05270</name>
        <name evidence="1" type="ORF">BQ5605_C008G05270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MGS6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY79984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="259" mass="29020" checksum="6CE9717027B01DF6" modified="2018-09-12" version="1">MRNVMFKLELINRDIAACREELACVNTKDTNKLIEQSTKLQQLVKQGQVLDDRLNSLRTSEINISVLDPGTSLPSSIDPPVYESACTLMVASRSLWDLVVQYRQGAARLRLPRLGGKALGTKAAGLLVMNFNSLSRRLMNAVAMYNDEVKKYAAILANSQNSHSILRTRRVPPSAPEDLNELLKLDILAPLWNNGLYSHPTEPWAYDDDVRVGIPAVLSRARCQQEIKRLGWEVRRIWTVADKRSQEVSASSPAITPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MH25</accession>
    <name>A0A2X0MH25_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C008g05390 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C008g05390</name>
        <name evidence="4" type="ORF">BQ5605_C008G05390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY80452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MH25"/>
    <dbReference type="STRING" id="796604.A0A2X0MH25"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006828">
        <property type="entry name" value="ASC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037256">
        <property type="entry name" value="ASC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF84">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04739">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01010">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160219">
        <property type="entry name" value="AMPKBI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Association with the SNF1 complex (ASC)" evidence="3">
        <location>
            <begin position="581"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="185"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="552"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="36"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="552"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="579"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY80452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="722" mass="74616" checksum="7E60D6C6C2044847" modified="2018-09-12" version="1">MGNANSSEQQQQQRVSQTGSAPSTSTGGERRKHAQSSNNSSAAPSPRLRTHTLPPTTSVATTTAHAEPSSSANAVAHSSSAAAAAAAASVASSSNAMIDDDSSTTRSGRTSEPGRRKKSLELSDVDPSLTFSSRAPSLARGVRRKTNDRIHGDIIIAPEDVDDPEPLGSGTLRGAMQGKAEHVVYGPRRSAPPETPMTLTPTTELTSRPQAIDLPTPDITATLVDPDDTVHPGFAASPRLTAAVILSQDQMPVLVSPISEVAPADSPLYGAGNTPSSQTSAAKSPIVPRSLSSVLSSVSAPSTDGLDAVERLPTSNLSATSALAPIPASQLQTPHTAPPMHTSIAPTDTVQAPPIPSNHLPISEADIPSGTSLIASPVVTPVPEGTPTGAIASPAVLLPPRLLNAPVAAIPIPLLSVPSATIAASLLAAAVDLGAGAEGVPTLIKWKDEDGQVPASSDGKRPAQGPSEVYVTGTFAKGWQTKIELRKANAADFSALISLPPGPHRLKFIVDKEWKASKNLPVATDADGNLINYLHVNAADSKLATELWKVSGTGSTAPTTRTQPSVSAPNSTSLWPTFGDEDDAEAPGADGLDDSEWTSEIPYELVEYGEWEAERDAIENSSAFLNPPPNSPPIVLPPPPAVSGVPPPSLPAQLEKGPLNHAAYVTQGSGDDNSILPKPDHSVINHLAASPIKGGFLSVGVTTRYKRKFVTIVYYKALAARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHC1</accession>
    <name>A0A2X0MHC1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C095g13086 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C095g13086</name>
        <name evidence="1" type="ORF">BQ5605_C095G13086</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000007">
        <property type="protein sequence ID" value="SGY11598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHC1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY11598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="113" mass="12249" checksum="D91F4A9F4A4DA1A3" modified="2018-09-12" version="1">MLAKLIPDILGGERLALDHLEIRIVDTLNDQGTGASVLLLQVHDHLGVGDRGIQTVHGPPLSQADVGGPHMPMLEDARIALALEVRLDSNRPQLVIILAELGYLDLPRLLSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHQ2</accession>
    <name>A0A2X0MHQ2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C031g10915 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C031g10915</name>
        <name evidence="10" type="ORF">BQ5605_C031G10915</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prenylcysteine oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000068">
        <property type="protein sequence ID" value="SGZ06075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHQ2"/>
    <dbReference type="STRING" id="796604.A0A2X0MHQ2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001735">
        <property type="term" value="F:prenylcysteine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030327">
        <property type="term" value="P:prenylated protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030328">
        <property type="term" value="P:prenylcysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010795">
        <property type="entry name" value="Prenylcys_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017046">
        <property type="entry name" value="Prenylcysteine_Oxase1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944">
        <property type="entry name" value="FARNESYLCYSTEINE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944:SF0">
        <property type="entry name" value="PRENYLCYSTEINE LYASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07156">
        <property type="entry name" value="Prenylcys_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Prenylcysteine lyase" evidence="9">
        <location>
            <begin position="234"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGZ06075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="603" mass="66319" checksum="EBD24B368CEA57B8" modified="2018-09-12" version="1">MLAEKGIAPHRGAPREQPIAGPSKTAPLYTSKRFLWERTRTLPGCLGVAIILYVLVSKFGPISRRTDTRYDSGFVDLESLSSYDRENTGQVAKWPQDNHESVSSLWSEPRVPKIAILGAGAGGSSSAFFLSHFAAAQNGLETAVTIYERSGFIGGRSFPVRPWLDDPYQIPNELGRDENEELVDPPVECGASIFAEANENLHKAARVFNLTLKDHGSEPGGMAIWDGLKFVFTESKGWGWWDNAKMLMRYGRAPLTMRSLVKTTVDNFLGLYKADFVSRGAFSSLFDFARATNLVSMSGSTAAGFLINRHQVGALFVNEMVAAATQVNYGTPVSKIHAVGALVSLAATGASQVINGNRRIFEHFVAQSGSQLRMGEGATVTEIEKIDGDRPKWRVQTSEANRGGDYDVGGDFYHHGIVILAAPFHQTDIRIRNSDVAKLIPPQPYVQLHVSFVITNLSAPQPSYFGLSEKTKMPKAIFATKDTGVAPGPTFNSLNYLQSLSKEAGDQFGQDSTWHVVKMFSEDKLAPETLNDIFGEGNVAKTWTKTFLAYPQLDPIRNPRKDLAPVRPDAGFYYTVSAFNVVTLLLQDLFNYTAPRSWAEWDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHX8</accession>
    <name>A0A2X0MHX8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C019g08939 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C019g08939</name>
        <name evidence="5" type="ORF">BQ5605_C019G08939</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GcvT family. CAF17/IBA57 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY23447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHX8"/>
    <dbReference type="STRING" id="796604.A0A2X0MHX8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GCV_T_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045179">
        <property type="entry name" value="YgfZ/GcvT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602:SF0">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00093447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY23447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="438" mass="48575" checksum="84589257D5BD6615" modified="2018-09-12" version="1">MNRISTQVRSWASMRPSLLACSCNTSTNAIYSTSSSTLLSRRTLSSSSACRSTPNNAPPYVYTSLPTRSLLRIGGEDVDKFLQGLITNDVARLRSRPTHALYAGVLKADGRALHDLFIYPSPTPSPSWTYLLDHPTEVSDSFRKYLKRHILRSKVKLAPTASTTEHVQVAWKPRKGEDAPPDLEVEVDRLALEAEEWLQANKALRDPRDGSMGWRWVAEQVPPPKLFQQVTPPYHHLHRLLLGIPEGQADLASLPLEGNLDFLGAIDFKKGCYVGQELTARTHHKGVVRKRQVPVRLFREGEDVPEELYPTYSTLKPYPELFPLPPPGSSLTPPSVIGTKAAPRHTGRLHSTLPIVTSSGSSFALGLATIRMDKLSPDAQNGGVFVVKAELKEGEEQGWGAGESEMEGERWFAKAFLEEGGWLSRGLRKERERKGGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIM0</accession>
    <name>A0A2X0MIM0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C009g05752 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C009g05752</name>
        <name evidence="7" type="ORF">BQ5605_C009G05752</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY85322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIM0"/>
    <dbReference type="STRING" id="796604.A0A2X0MIM0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21437">
        <property type="entry name" value="zf-HIT_ZNHIT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039723">
        <property type="entry name" value="Vps71/ZNHIT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13093">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="6">
        <location>
            <begin position="142"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="43"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY85322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="177" mass="19622" checksum="FAD6C747FFB059C1" modified="2018-09-12" version="1">MLQSTLKKKERRQPQRAHLGPNGLGGVPLDMDYVSRRIKRHLNDLERTNYTEPTTGPTAYGASDAPDEDGTEKGATPLRDDDVGRDKSGRKKRSMAVRSLLMYRKNLATLVDESGLSKLPPSTPTYLTASAPPSKRPPLQLCSVCGYKGTYGCMRCGQKYCSMGCRAIHDESRCEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJB4</accession>
    <name>A0A2X0MJB4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C034g11300 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C034g11300</name>
        <name evidence="3" type="ORF">BQ5605_C034G11300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000065">
        <property type="protein sequence ID" value="SGY99731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJB4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY99731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="63" mass="6989" checksum="C32FC4A1BB0F209D" modified="2018-09-12" version="1">MPAARPGAPRPPPITRAKATTSSLTWPLSFVAIVGVSILAYRQVLHRRHTDNRSSKREFPNPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJN3</accession>
    <name>A0A2X0MJN3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C020g09119 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C020g09119</name>
        <name evidence="1" type="ORF">BQ5605_C020G09119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000082">
        <property type="protein sequence ID" value="SGZ17407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJN3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ17407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="145" mass="16370" checksum="D5B86F997CC02801" modified="2018-09-12" version="1">MVGFYDDPYRALDHINWAIASDLTPGSQVASPTSPHPNNRTTSCVMCLSEAPECLVHLAVGCPFARRLWSALSPTPHPVFVDFVCPVVSRSERRLAELRVLFFHSIWKLCRRRRFSSDLLEPITETEFEGLRASIQESKGRLVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKC7</accession>
    <name>A0A2X0MKC7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C013g07126 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C013g07126</name>
        <name evidence="4" type="ORF">BQ5605_C013G07126</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY14842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MKC7"/>
    <dbReference type="STRING" id="796604.A0A2X0MKC7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.190:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.190">
        <property type="entry name" value="translation elongation factor selb, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00573">
        <property type="entry name" value="Ribosomal_eL33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001780">
        <property type="entry name" value="Ribosomal_eL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018266">
        <property type="entry name" value="Ribosomal_eL33_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038661">
        <property type="entry name" value="Ribosomal_eL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10902">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01247">
        <property type="entry name" value="Ribosomal_L35Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01105">
        <property type="entry name" value="RIBOSOMAL_L35AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY14842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="106" mass="11910" checksum="B6FA9A25EBB5989F" modified="2018-09-12" version="1">MPSTRLYAKGRVTGNQRGKRNVRVSTSLVQIEGVANKEEAQFYLGKRVAYVYTATRPINGSKIRIIWGKVTRSHGNSGMVRAQFRQNLPAKSFGHSVRVMLYPSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKD3</accession>
    <name>A0A2X0MKD3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C034g11269 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C034g11269</name>
        <name evidence="4" type="ORF">BQ5605_C034G11269</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000065">
        <property type="protein sequence ID" value="SGY99130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MKD3"/>
    <dbReference type="STRING" id="796604.A0A2X0MKD3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008501">
        <property type="entry name" value="THOC7/Mft1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05615">
        <property type="entry name" value="THOC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="211"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY99130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="267" mass="29958" checksum="A12064A2F437D637" modified="2018-09-12" version="1">MDTEAATQLAKTRVQDDTKILKKSIREFYRLSQPDLTPDQLYAPHPAPCQIHQLTIQPPINILSEAAHATFLIGLDQLSQQLVKPKRIRKVTQIEVSGYQDDALVLERTARETIQSIEALRTRLALAQQERARRIEYDAIARTIKKLPDRAKGSEAIAKLHQDIALLESEEATYSSTWAHRQVSFDSIVQSLETMSEAIRLEKLDQDRRKALEENDEDDQSGVLNPNATSFEPGGEIDREPQDGDLEEGEEGEEGEEGEMGDAGTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKT1</accession>
    <name>A0A2X0MKT1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C030g10838 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C030g10838</name>
        <name evidence="1" type="ORF">BQ5605_C030G10838</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000069">
        <property type="protein sequence ID" value="SGZ09072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MKT1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ09072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="370" mass="42989" checksum="26D655849FFF7C15" modified="2018-09-12" version="1">MLQQGGRLATRDLSRWEFFSTTARLEKLYRDSTHWGQSLKRPVSLFHRSIAQGESLARIPLKEAPRPRGFNFFKLSPPFTIRKLLRLVNMVRFPGREDCIKCFPRWTYQSDTQRFWRWLHDRFASVAEQDTHWRLMYHVTSTRKLQHIRGQASSPSSVFCGNDSAVIEMVSHYFFECAYSTSFWGGVLRILVDKLGIEDVNVDPSTFTPEQLTMGLPFCGVRLHLLRWRVHQRFELDNVVAPPSLPSALRAFERGFLSRAGFVPGARDWEWEDAQLSLLFAVAVFVLGWIGKPDRSSSCVGFRRMDRSFASVKIYGMDREERSFVFGQHPRLKARLVSLYWIVFRSAPTAQQPALETQPREDIRCCRDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0ML15</accession>
    <name>A0A2X0ML15_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C031g10922 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C031g10922</name>
        <name evidence="2" type="ORF">BQ5605_C031G10922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000068">
        <property type="protein sequence ID" value="SGZ06154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0ML15"/>
    <dbReference type="STRING" id="796604.A0A2X0ML15"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="1">
        <location>
            <begin position="8"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ06154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="544" mass="59593" checksum="7B037DA5697E24D8" modified="2018-09-12" version="1">MASSTLLVQTSAGPVQGFEDAHPLRNASSAALKGGTEAPIYKWLGIPFAKAGRFERPTSPDPWTQPIECFEFGTKFPQPVGASEALYQARLGDYRRDFVAMSEVSHTIDVYTPEGTKAGDALPCLVWIYGGALNTGSTSRIIYDPSHWIRDQAKLGRKFVVAAINYRVNAFGFLSSKDLQEVDKDGLSGNYGVYDCVKGLEWVQENIGAFGGDKDNVTCFGESAGGWMVSTLLCSGRRLFQKAIMQSGAAGTMSTRPVDTAFPAYAAILAAIGADKLPTAAERVEALKKAPMEQILAAHTASQTFAGVGFSIEEGPNATWDRKVVDKLRDGQWDPWIERVILGTNEDEGTMFTAGMKLHTPAAFDGYVANVLPRYKAQINKKYLRGAPHPEEVSLVEAPASRLLHDQIFSQPAYNQAKAMASQPNAKSGKPCTVYFYRCRAEIDSVTRGPLKLGSMHMIELPLIFNTKPCWDEGSHEEASAAVFGENWSRFAIDGKPVEAWQPFDSKKPSWFVFEDGGKTKTESLERFTDDFIDFDAPVDLTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0ML30</accession>
    <name>A0A2X0ML30_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C023g09596 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C023g09596</name>
        <name evidence="1" type="ORF">BQ5605_C023G09596</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ23543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0ML30"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ23543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="54" mass="6032" checksum="B11914B0B32F73AD" modified="2018-09-12" version="1">MCPPCPNHHSNSSGQLELQLEGPTSLTPCLNATRYASRYISIRPIRLRPRGANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0ML53</accession>
    <name>A0A2X0ML53_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C028g10451 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C028g10451</name>
        <name evidence="1" type="ORF">BQ5605_C028G10451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000080">
        <property type="protein sequence ID" value="SGZ11719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0ML53"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ11719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="124" mass="13808" checksum="B3959F7A30B5BA5D" modified="2018-09-12" version="1">MLTFVAREDQDVVEINEHGDVEKIAEDRVHEVLEGGRRVGETEGHDEALEVSIARSKCARAKVQFGVDFGAGVFGRGLQVEWEGVTIFASDLIEATVVHTQTKRSILLAHKQDGGTCGRRWRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLF5</accession>
    <name>A0A2X0MLF5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C028g10551 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C028g10551</name>
        <name evidence="6" type="ORF">BQ5605_C028G10551</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000080">
        <property type="protein sequence ID" value="SGZ13140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MLF5"/>
    <dbReference type="STRING" id="796604.A0A2X0MLF5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07031">
        <property type="entry name" value="RNAP_II_RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="5">
        <location>
            <begin position="29"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="331"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="331"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGZ13140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="372" mass="40166" checksum="ADA82BDFFA03BCA4" modified="2018-09-12" version="1">MQSTLPLDPPKTQAGSELRIQINKLDSERCRFVADGVNLALANSLRRVMISNIETLAIDQVQIEENTSVLPDEMIAHRLGLIPLWSEGIDRRIPNHNKECVCDAFCDLCSITLELNAYCTEDRTMEVTSKMLTVVGDDRSGIGRPSVGMLTSFIIRLSPAGDRDTGVMIVKLGKGQQIKMKCIAVKGKALEHAKWSPVAALGFEYDPYNKLRHTDLWFEVGTDPNEEWPLSENAQYERPPAKDGTDPFDFNANPTRFYFDVEAVGQMRPEEIVVKGIDQLILMLADVTTSIAEIAKPRVNSGQTPMHPGMGGADPGGGYGGAGQSGYAGGAGAGYGGYPQGGQGPAGAVPAAGGFPNYGARSPQRNGYDDFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLG5</accession>
    <name>A0A2X0MLG5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C031g10983 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C031g10983</name>
        <name evidence="1" type="ORF">BQ5605_C031G10983</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000068">
        <property type="protein sequence ID" value="SGZ06960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MLG5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ06960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="98" mass="11022" checksum="AC1AE431ED1611A5" modified="2018-09-12" version="1">MIQARIRRVGFTFARANAPFPLPNHSRHAHHLTRLDSTRLGSHYTTTLYPHHPISKMQLGHSRRTLDVCLCAGSRGHGATSHDTTINDSKLAIFSKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLQ5</accession>
    <name>A0A2X0MLQ5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C024g09805</name>
        <name evidence="13" type="ORF">BQ5605_C024G09805</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ25947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MLQ5"/>
    <dbReference type="STRING" id="796604.A0A2X0MLQ5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF21">
        <property type="entry name" value="DEAD-BOX HELICASE 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="66"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="285"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="383"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="603"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="386"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="603"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="636"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGZ25947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="679" mass="73828" checksum="7EAF345EC22E9D88" modified="2018-09-12" version="1">MQSGEPSTSTSTSVTPTIAPAVTKTSHQAKPISFASLEPVLHPLLLRSLAASQFPVATPIQASLIPLAISTHRDLLARARTGSGKTIAYAIPILHALLTQRAANSSSSSVKGTKALILVPTRELAEQVRGQVNKLIQGLGLSDDDEIGLINIAGGVDPKANKKRKIAKRGVEDKVQLADRPSIVIATPSRALTHLRSQTLHLADLTHLVIDEADLILSYGHSSEDIRSILNGPWGLPKVYQSFLMSATLTGQVEELKGILLRNPIVLKLEDDDDEIANLSQFFFLLIYVILKLRLIKGKCLIFVNNTDRGYRLKLYLEKFGIKSGVLNSELPFNSRYHAVQEFNRGVFGYLIATDESGLEGHDRDGAADEDLATGHIEAEGEGAPTFLTTQPAAETTTTDASAGTKKRKRNPKEASVKASTTEYGVSRGVDFVDVACVINFDLPFSSRSYTHRVGRTARAGRTGTSLSFVVPKESHGLKKQNDVSLPTAIRDETVFARIEKAQKGRGGEVKEYKFDLKQVEGFRYRMEDALRSVTKAAVREARIKEIKNEVVNSDKLKAHFEDNPKDLAFLRHDKPLHPSRVQPHLKHVPSYLMPRIAAVGSSTDPAEALNQVNTGGTKPFDPSQSRVPFHRAQRGGKGGRGGRGGRGGHGGKGSAGQPRRQDPLKGGKFSFGKKKEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MMT4</accession>
    <name>A0A2X0MMT4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C021g09299 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C021g09299</name>
        <name evidence="1" type="ORF">BQ5605_C021G09299</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000083">
        <property type="protein sequence ID" value="SGZ20776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MMT4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ20776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="77" mass="8480" checksum="BC815843105306A6" modified="2018-09-12" version="1">MCSITSSLNRGSRRELLLLDPVYRSWSTNAREGTYNGRKVGKSYATPLPVNVDGHAELCTHTIPRVEDVCAVVCSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MP90</accession>
    <name>A0A2X0MP90_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C022g09578 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C022g09578</name>
        <name evidence="1" type="ORF">BQ5605_C022G09578</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ23036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MP90"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ23036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="395" mass="43763" checksum="13D64908AF27878C" modified="2018-09-12" version="1">MMNIFYKNKNKTDRGVRIRRSQQFPDRGGSENGRFKYVDDTFALPLLTTSINIGVRKPDGSVTHKDKTGRLSFADLVANLEYTFTARLCSLEETQRRGQPPNHKLLQLLNNVQSILRQHPSAEFALGFAIHLDTAYAVKVDNEVVRIVELKDCWHDVNLPKMAALFRIFLNVDYDSSGFSPVFRCEFTPVSGFNETALRVESLGPSTQQALQGRDEKAPEFVKVSSLDCIPPSVLAHSGSGAYAAFKLDTPPVLLPQLGGSDKILTTTNDSSTATPSSRPVYQLWAVRRLLEHAEETNKAIREVAVSIYMVANLPSTTLRHVALAVDCHSIPASKRRLPGLPNGGKRRDVGILTIAVPELDHPHKYRSILDKKNPPTIAELANLLASALDDILRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQA9</accession>
    <name>A0A2X0MQA9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C025g09963 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C025g09963</name>
        <name evidence="10" type="ORF">BQ5605_C025G09963</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000087">
        <property type="protein sequence ID" value="SGZ26804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQA9"/>
    <dbReference type="STRING" id="796604.A0A2X0MQA9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494:SF1">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="633"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="50"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGZ26804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="681" mass="76525" checksum="D8AFDB020AC74E05" modified="2018-09-12" version="1">MTPPQILSLHHGVHAIGSGGRRHQLGQLLPHQRRADSFDDQLAQRQAQAQAQDSLTGYTSELEQSTGATMSLDPRSSDSTSLSPLRDSFPHHRASYHAAAKKLAQKSGRCQTRPPGIDARRIDLPKLQAPCVIQVVDCAKDPCAFLLQRCCLIDQFVQFRVFDNSTLGAFLEEPRPVKSKLRYIHVNGLSWDVIKPLAIHHHGTSATRTSLGSKADYFRQHLFVSLLMQNVVNELEEVDGNVDAPFDPSAAPCPIRDARGSHLDEENIIGSPDHNVDETGQADIEEHALLSHAEYVLALNEAFERLESCSPAGPKNGHELVYTNSAEVDPFFESPRAHSRSNRLKQNERRAARWTVAELTKEAKVRISVEQLSVFLLDSTVISFSQDPGFHPQVSSVFDRMASQDDLIRDSEQPSMVLQALIDVVVDDALVIVDEFRDRLTRIEATVLAHADDDDVRRLHILSSQVRINSQTGIRLLLLKSTFSPLQLLISSLRTQDEAKYAATLHHNSTNPVNAKNRRGWVTHQAQLYLGDVLDHIERVLGDFELFSNMSENLISYAFNMSAQQTNSYMQALSVLSSCFLPLTFLSGYFGMNASFSFTLRGAVRALRCLTPEARARKQFERFPHVLDGDVSYFWIIAIPVSAATVILFSWTYIRTWVSAMKRNFMRLNHRRIVYKRDKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQP9</accession>
    <name>A0A2X0MQP9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C019g08831 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C019g08831</name>
        <name evidence="1" type="ORF">BQ5605_C019G08831</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY22621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQP9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY22621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="259" mass="29086" checksum="250148BC2A6B7D90" modified="2018-09-12" version="1">MRNVMFKLELINRDIAACREDLACVNTIDTNKLIEQSTQLQQLAKQRQVLDDRLNSLRTSDINISVLDPGTSLPSSILTLWCDPRCPRLNISIPLIGTDYEFACTLIIASRSLWDLVVQYRQGAEKLRLPCLGGKALGRKSMQCQLIGTKAAGLLVKNFNSLRPRLMKAVAMYNDEVKKYAAILANSEDSHSILRIRRVLPSAPEDLNELLKLDILAPLWNNGLYSHPTEPWAYDDDVCVGIPAVLSRARCQQEIKRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MR83</accession>
    <name>A0A2X0MR83_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00592 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00592</name>
        <name evidence="2" type="ORF">BQ5605_C001G00592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY47931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MR83"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015883368" evidence="1">
        <location>
            <begin position="21"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY47931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="142" mass="15453" checksum="DF600253360B13A7" modified="2018-09-12" version="1">MRPFSSIILATCALVYLTVANPSTTVKDHAFSLNSVQLQGSLESTCHKRTPNVSCTETTVEDDGDSPTPPLCASIGAVDLQEPTRRIVPVRFRKSIESKLASRDVFPKRLGSKSRRAQTLLSRSDAAICITKTPPLTIARLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MR86</accession>
    <name>A0A2X0MR86_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C019g09011 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C019g09011</name>
        <name evidence="2" type="ORF">BQ5605_C019G09011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY24102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MR86"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34862">
        <property type="entry name" value="SPARK DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34862:SF1">
        <property type="entry name" value="SPARK DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015871720" evidence="1">
        <location>
            <begin position="23"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY24102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="338" mass="36300" checksum="A07B7195828D851A" modified="2018-09-12" version="1">MHYTRLCLLCAALSNAPILLSARPQITMSADLSLECFIATTGLLSSPFARCADASGFLAALDAKIGLADALSDWLNNFCKDTCPDDARAKAWSGLEGGCADELAREIALPVRSTWLSSVLLGTGHLRSSATAVQCPFRFDNFVESNPILNAGSTAVVANYDVLKRGACTGSVSRQSYCFVEFVKDLEEANKRNFTMSVDLLSPTCAELNAVPRSKLCTLCNQMLFEMMVKLLSRPIDRVTLTDHARQACGLAFASLSALQADFPLRPVGGQFDQAVARYTAAAIKDLDQHNSTPSTPTTSSAYSSRTLSRRSTFALDTVVKAVAPTAAATILLYGWVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MRJ4</accession>
    <name>A0A2X0MRJ4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C065g12805 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C065g12805</name>
        <name evidence="1" type="ORF">BQ5605_C065G12805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000133">
        <property type="protein sequence ID" value="SGZ35230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MRJ4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF29">
        <property type="entry name" value="PEPTIDASE A2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ35230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="235" mass="26422" checksum="85FE25DB5FADD187" modified="2018-09-12" version="1">MGCSTSFFARGSQESVPCGIWQLPIYTVDFSSARAIDRAPRFDGFRLVPPFRVEKVDFSSARAIDRAPQFDGFAKKVDFSSARAINLEKVDFSSAQAIDRALSIFIFTGNLGFYSKTYPGIGLYPTYDTLKVCPVWVEFLGMDCQFGTIRMSQAHKDVILIIAKPTTKVQLQHFLGSVEWSSCYFPHLAKIVAPLTNLVGDAPWTWSAAQDIAFEETRRRLMVLSGCQRGFRTWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MT11</accession>
    <name>A0A2X0MT11_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C048g12410 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C048g12410</name>
        <name evidence="5" type="ORF">BQ5605_C048G12410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000110">
        <property type="protein sequence ID" value="SGZ30565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MT11"/>
    <dbReference type="STRING" id="796604.A0A2X0MT11"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018834">
        <property type="entry name" value="DNA/RNA-bd_Est1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019458">
        <property type="entry name" value="Est1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF36">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10374">
        <property type="entry name" value="EST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10373">
        <property type="entry name" value="EST1_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1021"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="domain" description="Telomerase activating protein Est1-like N-terminal" evidence="4">
        <location>
            <begin position="147"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/RNA-binding" evidence="3">
        <location>
            <begin position="328"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="596"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="755"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="821"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="875"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="598"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="760"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="826"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGZ30565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1070" mass="116656" checksum="570189061249E861" modified="2018-09-12" version="1">MAAAGLPTATTATPAPPRLVATRSDLGNRVAPQLSSEYDRRPSRSSKPSIGGQSVAALLREAKALTLDLRTAIKRKDPWDREVEFQRESVRKAYSRVLFSSTVGTSSSIALLAASSSNPVSGPSNALGSTTSLVSPSASHSTRLLEALNSLWLETSHSIIKAYRSRISAMDKTLAEAPQPHRKGGGGAARGEPPPPGPTARRKLVHSFRTFLAKEEEYFTTLLGRLASDLSPNDLEGFNALGVVVEPVEVVEGLPPTSEEDKRRARSKAVPLVHKALICFGDLARYRELFNEHSGPQAKERGGRRGNKSKVTSAGGSERNKPKNYSRASACYTQARLLIPENGNPSNQLAVISGYTHDTLSSTYHYFRALSVRIPFPTARINLELAFNKAVTRWFERPSGWREPTPDFVTAFIALHGLLFTKTRWVERSGRAQPRTRRLTARGVSARRLSDIAPLSSKVESSFQQAITSLELSPDTIIKIVVTGLCSLWDARVHRSSSNPRKTPSKRSAEAGSNANSAPSVNINLEPHILLHVLSMYTILLRICTNETAEAYLADTTKQAPKPGLNLAQNISAVLDYIHRVESRLRAKEIKINRAKAADSATQASQADTTQRSSSVSDGQHVESSQDQSMETDHVNSRSLEDALTAFWTSYADFANSFKLVFPTEGLPSPADDGLWLEEDVDLLGFAPLRRSMKDVKGTDLAVEASKVGKEVHPNEEHLMRIAELQSDAALIVESEICPVIVELGAYVLASPKSSAATTIEDEVEEEDEEDEAAPIPASSPTKALSRGVDSLDLFEQADEGSEPTEDDPVDLAMRIAAADRLEMQDITDEEDDDEDDDDGHIVYRSRLNLGNIGRRHEHPHRRRNSMDLRSLWARPPGDSPVPAAHHALPPPHQSSRSSFEALPNMTHQAARIIRRPFSSRCASGIGSTSVRGADRLVRPASPFPPPGGGPVVPRHSNYHPASSTPYDSGSFNPLPYHAPPLFPYSNTTFDPSRLGLNQTCRPRPSHSSAVALVSHLRVRLVLVVVAGPITAVPTLGAWILRIAISLTGRIVCETHSPLFVILCCSWFCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MT51</accession>
    <name>A0A2X0MT51_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C044g12151 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C044g12151</name>
        <name evidence="4" type="ORF">BQ5605_C044G12151</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000114">
        <property type="protein sequence ID" value="SGZ31342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MT51"/>
    <dbReference type="STRING" id="796604.A0A2X0MT51"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="141"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="2">
        <location>
            <begin position="420"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ31342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="472" mass="53207" checksum="40AC68381398F667" modified="2018-09-12" version="1">MSRYSFTDPLPTLVAAVSHVKLSDAVKQQILDAYETNPFCQQAMSNIGSVTSDFKIVDALLYLRGRLTIPSLAPLCESILHDAHDAQGHLGDMKMYRTVQQAYFWPNMSRDVKHYVQQCDSCQRTKARTTRIAGKLHSLPVPTRPMADIAIDFVGPLPANKGFDRVLTITDRLSGYVRLLPAREADTAAEVAARFHEGWHRLFGLPQSIVSDRDKLFTSKFWTALHKRLNIKLQLSSAFHPETDGRSEKTNKTAFQILQALVNKEQSNWAECLSVCDSCLATRPPLPHLPVSTVMTTCRPLRSCLPFDSKPAKTPGTSLPFPRFGRQHSPTRGVGMNPLGLLGILYFSTRLMDRFDDPYRIIKAQPEILSYTLQLNGDDAAVPFFHTGKLKTYCKNDTALFPNREPARLGPVDVGGEPEYITEDIVDERIRAGKQQYLVSWVSWLSDSNSWEPAEALEDTEALDRWERRNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MTA3</accession>
    <name>A0A2X0MTA3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g04158 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g04158</name>
        <name evidence="2" type="ORF">BQ5605_C006G04158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY56690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MTA3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY56690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="58" mass="6767" checksum="4BFC31CFBDC64185" modified="2018-09-12" version="1">MLRSSSIFPKSRRASSRPPALRPLSISQGKWVNAASKWCNYQLRARVYPRSLTHLPRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MX03</accession>
    <name>A0A2X0MX03_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C005g03164 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C005g03164</name>
        <name evidence="8" type="ORF">BQ5605_C005G03164</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY72374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MX03"/>
    <dbReference type="STRING" id="796604.A0A2X0MX03"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000006">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000008">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF51">
        <property type="entry name" value="MANGANESE RESISTANCE PROTEIN MNR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1095"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1126"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="108"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="198"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="332"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="584"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="631"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="735"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="164"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="350"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="396"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="449"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="590"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="764"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="780"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY72374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1155" mass="125302" checksum="BB14B4E32C0FF02E" modified="2018-09-12" version="1">MPAPLPHQAAVGSALLESARTSSSPRGQDHLAPSSPILVGTSGSHDLSNRSSPRPESEMGDFSQLDSRDLRQWEQDAQLAQSMARPTMLNALARTRSNTVLATGNGVGVGAGATHSHSPDATATLDQLQQQQQQQQQQQQQQQQQHHTPQRNNSSSSGDQAYPHSHHQHQSSVSRRRGSVSHQANAMDHLADDLQRDVHHHRQHHHEHEHSTSMSVGRPPITPAGGSSRQHALSSASHHSGNNRSTPLRYGAGPSSGTPISLQHTAAAARLYRHHRNVSESSLDSQGGAYIDHRRQPHSLSLGTGASTNARFGASAGAVPAASVLERAGMVARSPDGYGGARLFPNPGRRRSEGGTGDDHDDHDGAGDNIDELSLGRSAGGPHDSDMVNSVLSSRTARDGPSRDHDLSSRDLDEHALSMSPDERHEHRPRAHLDRHDSRQSYRSTTEGHLMDDVDEDHHANHHDMGRHYSNDASRRESFVGPPEDDICFPTHGAAAEVDLIDMGHLEDQLHHHHHHHDDHHDQFNGGVAGVLPNFPYPFDFGALEEFADREKEGLPIPGAKRRGVKIAGGQPCDTLGVSPPGYGVSSATSRGGAFSSGSESGFGGVRRQRKLSESVAPGRYRRKLALFEGTGDDAGSSRGANTGAADRDGDANGGSHSILDTKTPLLDKNATAAASGYGSRGGPVGGGGAAALGASRPYRFSFYSNALPSTIHARSLAEIPAENQTFEELFVGRSSSPTTAVDDETSFRQSTGTMDPKLAFSPPSGTETGTHTPNHDHAPAGAHGASASGARPSGVPHGAQVRAAHARNNLMRSDVDAEANTWWLDVLCPTDSEMKVLSKVSSLGWLSSVTNRVGCSLTRSRSLQVFGIHPLTTEDIQMEETREKIELFRNYYFVCFRSFEQDPYSPTYLEPLNMYIIVFREGTLSFHFRGTPHPQNVRRRIKQLKDYINVTSDWISYALIDDITDAFGPLIQNIEYEVDSIDELVLILKEAEQSDMLRRIGTCRKKVMGLLRLMGNKADVVKGLSKRCNENWSVAPKSDIGLYLSDIQDHITTSTQNLTHYEKILSRSHSNYLAQISIEMTDANNQINDVLSKLTALGTVLIPMNLVTGLWGMNVHVPGQDATSLHWFFSILGCLGAIAIGGAWLTYKVFVRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MYN8</accession>
    <name>A0A2X0MYN8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C008g04935 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C008g04935</name>
        <name evidence="1" type="ORF">BQ5605_C008G04935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY78747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MYN8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY78747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="53" mass="5999" checksum="57BEBBF14A57E508" modified="2018-09-12" version="1">MDRDPPRLQVLDDLFGQLTGHPEPQNRPWLVSTESVSRRALGVESLPDGVYPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N408</accession>
    <name>A0A2X0N408_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="17">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">BQ5605_C005g03186</name>
        <name evidence="21" type="ORF">BQ5605_C005G03186</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 17">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Membrane</location>
            <topology evidence="1 17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="17"/>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY72588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0N408"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000087">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF153">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 16 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 17" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="549"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1220"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1248"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1299"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1360"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1406"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="19">
        <location>
            <begin position="98"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="20">
        <location>
            <begin position="1185"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="246"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="705"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1580"/>
            <end position="1650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="254"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="277"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="309"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="712"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1583"/>
            <end position="1593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1610"/>
            <end position="1620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="1641"/>
            <end position="1650"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="14">
        <location>
            <position position="672"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="672"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="672"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="673"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="674"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="674"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="809"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="852"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="879"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="913"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="993"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="994"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="995"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="1133"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="1139"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="1159"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="1162"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="1163"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="1163"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="SGY72588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1650" mass="183197" checksum="29E0598BB5C7EE71" modified="2018-09-12" version="1">MVEPIPTRGPMNRWSRSWARLNNWSVLSVFDPKRRMPQPRSVLVNVPVPSHATMMAPKVSVPFMAKLSKVELPDGTTQLTKRKRGFGSRIRPAPGWIFESNQVLTSKYNVITFLPRNLVEQFRRIANIFFLDEGSHRGCIESAQLSITVLVILQFFPRFTTVNPGLSALPLLAVLTITALKDGYEDLKRHQSDRSINNIKVLALRGTFHNPNATRIKSSTFTLPAFIRNIFVKRSLIQEARAAEEERQAERKKGFWGKRKIRMPKQKKAVSTSETNSMHEQESSEIPRDAPGGGNVQSAKKKSAAREAQAPERHERLDGDHYADDEDLATSQVHGSDAPHSGSEPHHEGAHLPHLGGHHYSHAVWAKECWEDLRVGDFVRLRGDESVPAGECDCWITIRSLQHVQDRKLTSCSIDLVICATSEEENVCYVETKNLDGETNLKSRHAVPELTHLRTSTLIETEARFTINAEAADVNMFNYNAAVILEDGRLGKDGKPLRCPVNLNTVLLRGTVVRNTDWVIGVVVMSGRDTKIVLNSGGTPSKRSKVERLMNPMVFINLALLAAMCIMCAIVDHFLEKAQYPEGAYWLYGADRGDDNPNINALITFANAMIAFQNIVPISLYISIEFVRLLQAFFIYADNEICYRNGTTKRRTIARSWNLSDDLGQIEYVFSDKTGTLTQNAMIFKQCSVAGKVYRGDGLAPAGTVVPDVNRDSSSSGAPTSHVGSASDAEKGDASSGLSSEGHDKKNSKLADTVLAPFHDAEIGSDLADRDAEASTNLYAFFSNLALCHTVLAAEEDGLISYKAQSPDEAALVQAAADVGFVFLGRDKDVLRIQTPHDDDVVEYVLLNVLEFTSSRKRMSVVVRRVSGGHAGQLYLLSKGADNVIFERLAPGSEQLKMATDKHLEEFANEGLRTLCLGYKELDEDQYEAWEREFHEATTLIDGREEAIEAASEKIETNLVLLGATAIEDRLQDGVPEAIADLKRAGLKIWVATGDKVETAIAIGKTCNLLSRDMNVIIVRGGEYNMPSSAYSQIRSALEKFFDVGDLADRVYPQPPDAVENPPRASDLPGGLKRINTRQSGLTDIVGDDNGQRPGGYGLVIDGATLRHAFAEPYTKQLMLELATRCRAVICCRTSPLQKALIVRLVKDGLGAMCLAIGDGANDVSMIQAADIGVGVAGEEGLQAVNSSDYAIGQFRYLQRLLLVHGHWSYMRNANMIVNFFYKEIIGIGILFWFQFYCGYSATTVYEYTYLLFWNVFWTLFPVIAIGVFDRSVSDRVLMQVPELYVYGRKGALFGLKRFTFYMLDGIYQSAVIYFFLAYAYDTTTARRDGYDIQMYEFSTVMAISAVIAANLYNGLNTKAWTWWVAFGVFLGPVLILLYTAVYSAFSPSFIWSYVYGNNQFLWPSVYYWLGLLFTIVLSLLPRYLYRYYKENYYPTDVDILQWTDVQEPKHDWVNDPYMPQRRGASGPATTSAHDIYQHDNGSAHADDTHPIFAPGRPSLNEEPNSFPLGHRLSRQSTTHDMSTGLVSSGQGRGFNYDEQPPAPLSIARYTSRTSDHSSIRTRPRKGSLRLAGVELNPFARSPSRTRTGSVLNPSRLFSGRRSAIPEGNEVTTPTRSSIARSPRPGQGGESTADYPMSGEGTIGGGSPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N5I1</accession>
    <name>A0A2X0N5I1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">BQ5605_C005g03726 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">BQ5605_C005g03726</name>
        <name evidence="17" type="ORF">BQ5605_C005G03726</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N5I1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="16">
        <location>
            <begin position="216"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="498"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="552"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="589"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="SGY77789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="713" mass="77932" checksum="1E85A92E1CBD61F2" modified="2018-09-12" version="1">MPERWDSDPVPVTPDLFLQFRDSFENDARLLQDSQVTVNALLASHLLARLPSSFDAWRTTFVADQGDSTAMPSATAIFTRLYRDVKARPVDTPVAAVATPQARHGCSRPCPNPSCRKLHWLRECPDTAWAAAYRARRTAEKKASQPVASPTPCTPKALLAVPANVSLLTLHRRLAHLPVAQIKNIVQSGLVTGVDWVYKDQELRDFYCNACLASKAHALPFARSKSIASGRLDLLHVDVAQMPRPTFGGHRYMLVIIDDFSRKHWCILLALKSDVFPRLCDWILEVENATGNKVKTIRSDNGGEFTLRNFVDFCASKGIRRELTIPYTPQQNGRVERSNRTIKEGILALLYSSGADSRLWGEAALYYVHCKNLMPHTGIGGEIPDTRWHGFAPDISTLRAFGCRAWHHLPSAKRTDLDPKAVPLLFVGFDQHAKAFRLFEPSTRRIQLSRNVVFRESEFPALRPAPDVRAEPIPLPVPVDAYPDQVDPLEPSLVASPRSLAPRAEPPRPVPAAPDQGPHRPAPAREVPDQDSLAPPAPDQGSPALELPDPESPASSASDQGSSDSAISTPCPSPRPVASRALPAPPSPARSDSPDPIDLLPRPRDVASLCQAQEFPDDVDDALHSPSAVAYLASGAAALIETSPADPAELIAPARDPPHWRAAMAIPQADEWRLAARDEFDSLLRDFSAFTPIDESLVPADAKVLGSRSSLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N5R3</accession>
    <name>A0A2X0N5R3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C008g04987 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C008g04987</name>
        <name evidence="2" type="ORF">BQ5605_C008G04987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY78906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0N5R3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="645"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY78906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1840" mass="202916" checksum="65035701DA3FC4F5" modified="2018-09-12" version="1">MRAFVCSKFGHNPAKAMIPALAVLPTHAGSRAVLATHVPFWAFTALTTFPPVDAIAVLLTREPTGGTCNARSLSGLHCVVDVSLPASVAAFTTCRDRCVPHSQDYLPADEVADREFNLAGRSQLLAARYETLDVAHYEPFAVLCTNRGPPKAQPEAHFFFFDILRTQNPENRRGASQKIDILGRNTLGPILAYPEQPTASLWARLSKRASRCSRLNKSLAIFADHFSSVAHDEMIPCLFLDEDQNYYLHDDDFDRSSPLTNMTVAELLAFDVAPADASLHIELSKDEPTQYSNLPYPTLQTRDAFLATDALINARKQGYRSLAVGSTCLPLGADRLWSEYDRAKDVQSWALRAQRWMDKIIVINEIDRNRIAVARRILNGLQWQEQDGLLPLPLLASGTSLVYLLRFLSQQLAYSRLYPGHDWLGEAAVNLSIESVLRAGRVQNPDFETSYGLIPSTVISLVMARPPDSDPHSVFKACFFGPPNQYRNLIELGDCMRNTPTPKSIWFLPLCSDSHWVLARINMHKRTWSVINSLSATPITAATRTAVLTLFKFLKLDIKNEFPHTPKAEQQEDSYSCWPATINAVETEVLGIGSFNAARAHMSRLRQFCRLSSLVGAVEDPKEIESIVATGAKLKAKSGRGSAAGTLSSKSTSAESGKAATIKPTNQRVASSSKNPPTSRLQTTFTKASKPTKARELTPEEHMTWARDHPPLFRRFAEKVEDLCPGSNVDVNNPKYVRCGRCYVLVPMAALLCKARFQLHLGNKKCVNLQPISNFFRPIASGSTATSPSLGPCPGLTSETAMHYLSSTAAQGGGAPPRRTLCLRLYPKFGKRPMTEFERKEVDKLEANEWKWRNDHRAPRIISVNCRKYSARDSINKDGPSLPCEECARLPKDSSCRAALRRQYAAGATRKYTNKKYVAGDTLLSAIYRRHHGLEEILDDNGQGAVYLRFAQGVASGEFDGANILEGLVKAATVKHARMVKGKSMRGFVRSEALRDFEQAMALASPMALRVLQATIGASTSRKLQMRLGLDKSNMDRVCAKLEADGLTFNLHVDDTKCRSRMRTTPYYSEDLSLERELRTKGIFRHELIGSIGPPRIYETPGELPEMFSGPDPPVAGTKIRAYMIAPNDVGSPAQVFAAFVIGETTNAEDATEQLHSVIQELIKRCVAHLLVFISADGAASEGVLQRNVAVLLRDQGGAVAQTGSRNASSYTLPSPDPDGVFPEITISTVNVAGTPIVFCRDEKRLAKCLRNAIDSGARLLFGGLGCIAYQDMLTILGGLESRRTLSRRDVTKNSTPMRSYISSYVASYTMPSRTGRFSPLNVSGCCSLSDIRSRRGMTLSEVAPDLALTRSSPKKRLMGSGRWLTQRLLSSATTEIFGRKNRSFPGGMAQKWWSTSSGVYARLIRQATGKVTALLELMRKFKTEAAGSRQGYHYTYNDLDDLDLVAMRTYPSDGDISLTSFAAANTARELLSGLRMWEPVQRIASNRRNQGPQPDILVEDVLAHGTTVQDLEDHHPTKEDQGLLRTELLDSALDGMRRSTCQGVVKLDPNEREAVDRAIRSLAALDFDVEAALLDVQIAYDEADRQAEERYVLETTEKANSSLRPIPTHLKLPPLVDARDTSFSLNWASLIAHRAAHECSHLRAVLLKGRPMELNDTSRGEAGLEISNTEQGRSAVHSRVLKGLVQSMGPSRFEDIAGTARSFRWTGGGQVARALTTNEIQKNAYIEDGRIQEKLPERDKQYGALAQSYPHFGSLDGAVTAATPLEIGSLICFGLKRGMHSLSCDQTAYYGEEALSIGIGTFDNKPLQPRHARLVGSTLKCRRTGASPHQENMLFHTPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N7S3</accession>
    <name>A0A2X0N7S3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">BQ5605_C009g05748 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C009g05748</name>
        <name evidence="13" type="ORF">BQ5605_C009G05748</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ING family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY85263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N7S3"/>
    <dbReference type="STRING" id="796604.A0A2X0N7S3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF42">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="506"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="259"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="391"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="509"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="511"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="522"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="527"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="533"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="536"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="549"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="552"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="508"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="519"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="523"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGY85263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="564" mass="58887" checksum="D42CDD6F5685FD69" modified="2018-09-12" version="1">MAAPQYTPSSEIIHLVHTFSDTLDALPPALTRSVSDLKELDAVLSGQSLPSCVARRACAAPTGDHLLCEANNVFLGSLNLITTKLQKLLTMMITPPPPSSSAVAAGNGNDPAACTPYDRLRLLREVTEDARVFRLGGEDKIRVATSTCETIATHQNHLATLSTLLLEFLPALMLPTLPAPSAPHGYPQSNTADTAIQRRQMFHLPPERHPGQGSTSRMSAAMGMARDLYEATSSSRNTTLGNGSAAGARTLSTLAPSASNSAAAGASGAAGGGGGGGGGSHKKPRAQNANGTAHGEKEASKHPNQYTKKRIAQAHQTAQANAIGVHSLTAQGGVIASAPAVNAQAGVYAHSASFGGMTAVEAVKEKRRLAGTSANTGVDYAQNGGGLYPEEHAMPQSISPRVGGKRKGEEGYGARKKSKKTVEASPDPTPRTLPTATTTTTSASAPTTTTKTARRAATSAISAIKDSAIDPFGMNAQEAAATTQQASMNKLQEATDLGDDDETDKTLYCLCQRPSFGEMIACDGPTCPHEWFHLDCLKMSSAPKGSWFCDYCRAEKEKKKGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N869</accession>
    <name>A0A2X0N869_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C039g11772 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C039g11772</name>
        <name evidence="3" type="ORF">BQ5605_C039G11772</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000060">
        <property type="protein sequence ID" value="SGY89838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N869"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016055960" evidence="2">
        <location>
            <begin position="20"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY89838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="188" mass="21157" checksum="B1EA164E24B48BDE" modified="2018-09-12" version="1">MRILAFLAFVFVVSEGVLGFKYSHGEGQLVPNTAYLLRIRNTASFNHSHTIFDACKRLYEACDKYVKPIQEVRPDGAHFAHHHLDCRPDLSVLPAFYATCGYRISPTAGEPSSYNASDTPVDVTWEAFQGIKEYRIFPRGDEMLRGINPGQAANPAGHHSDHSHQARAESQPHHRSRIHHRRSLKAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N8I2</accession>
    <name>A0A2X0N8I2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C038g11710 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C038g11710</name>
        <name evidence="2" type="ORF">BQ5605_C038G11710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000061">
        <property type="protein sequence ID" value="SGY92013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N8I2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY92013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="193" mass="21969" checksum="93005CEC02AEE463" modified="2018-09-12" version="1">MTRNRRRYDLTTRQDRRRQANLFARFRLHKLSLCQHLSCMYLISSYNSPAKMAQTHEAESIIGLPTRWMKRTKSAFVSSHDMAPEVFASDQIDARLDAIVESNSFITGCIRNLLSHCGDPPPVEESNCDKLSSDSTDVDMEDAQEDSSRSDAERGCSKEQHISFIAFACNRRNNAMQHRNGLMALSHVERTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N959</accession>
    <name>A0A2X0N959_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C036g11559 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C036g11559</name>
        <name evidence="1" type="ORF">BQ5605_C036G11559</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000063">
        <property type="protein sequence ID" value="SGY96321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N959"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY96321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="188" mass="21309" checksum="60CA34734D6108AB" modified="2018-09-12" version="1">MLGLKGPPQPGDLRSFWKAVNSKALAAREREVWFKLILRFTPTRKLQHQQNHDTSLVCLVCEAPVDDTDHYFFGCVDSRNVWIAARGVLCDALGCDTIEDAQYTTLLNLPQQLQRLFGLPKLKAKLSKQEGAGRTIKIFTGMVLEMISSGRWRMQKHGTRMESVERRRVVLEERMKLRAGGARGGRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-11-27" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NAI2</accession>
    <name>A0A2X0NAI2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C050g12494 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C050g12494</name>
        <name evidence="2" type="ORF">BQ5605_C050G12494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000097">
        <property type="protein sequence ID" value="SGZ29742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NAI2"/>
    <dbReference type="STRING" id="796604.A0A2X0NAI2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF34">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ29742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="245" mass="26736" checksum="25F7356D37FDDB34" modified="2018-09-12" version="1">MATQQTGLSPLLALMNERTVLDYDNNDATLCEIYPKGTFTDMTSNQAIVAGELSKPHHQHLMLEAVKEASQLVLDGFEGVKRRDVASVAVDIVTIKLALPILPLLKPTGLVHCQLSLGASSSLENLLHQGRSVISLYEHYAIPRSRVCLKIPSTLQGIQACGVLEEEGVNTLATMCFSIEQVLAAAKVGARYVAVYVNPLEVHFVPGIHRELGLHGLPGYEVLRVAQKTLKMRGWDAKTKMMAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NCI2</accession>
    <name>A0A2X0NCI2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">BQ5605_C020g09153 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C020g09153</name>
        <name evidence="13" type="ORF">BQ5605_C020G09153</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing and cell cycle progression. Required for the spliceosome assembly and initiation of the DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000082">
        <property type="protein sequence ID" value="SGZ17938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NCI2"/>
    <dbReference type="STRING" id="796604.A0A2X0NCI2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000048">
        <property type="entry name" value="Cell cycle control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000306">
        <property type="entry name" value="Cell cycle control protein cwf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000796">
        <property type="entry name" value="Crooked neck pre-mRNA splicing factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF3">
        <property type="entry name" value="CROOKED NECK-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02184">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="10" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="12">
        <location>
            <begin position="59"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="12">
        <location>
            <begin position="312"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="578"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="708"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="578"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="719"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGZ17938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="745" mass="88006" checksum="EBFDABC7B2DEC4C3" modified="2018-09-12" version="1">MSQREGAGRVKNRAPAAIQITAEQLLREAADFQEKTAVKPKQHVEDLEELHEYRGRKRQEFEETIRRTRSNITAWAKYANWEAAQGEFPRSRSVFERALDVDPTNLKLWLSYTEMELKARNIAHARNLFDRAVTLLPRIDRIWYKYVYLEEMLGNVAGARQVFERWMAWEPDEKAWSAYIKLEIRYNELDRASVLYERLVNCHPEPKMFIKWAKFEEERRRLDRAREIFTMGFEFYGQDEQGIDKSQSLYSAFAKMEVRHKEYDRARVIYKFALERLPRTRATQLYAAYTNFEKQFGDRQAIETTVLGKRRIQYEEELTHESRNYDVWFDYARLEEDAYRSATAGGQADEAALTRVREVYERAVAQVPPSDEKRHWRRYIFTWLNYALFEELETKDLSRARDIYKACLKLVPHKRFTFAKVWVQYAEFEVRQMQLDAARKIFGTAIGMAPKDKLFKEYIELELKLREFDRLRTLYQKWLEFDPSNATAWIKFTELEAGLQEFDRARAIYELAVDQPSMDMPELIWKSWIDFEYEEEEYDRARELYERLLQRTSHVKVWVSFAQFEANAGLAIARAYAGEDEEGEEEGAEEKEKTEVDHEAVEQAKQEGLERARAVFERGYNDLKKKQLKEERVVLLEAWKALETNEGDAASLAKVVAKMPRVVKKMRKVDGDASMMEEYYDLIFPDDETATNAVSLKVLEMAAAWKKKQAEMAANKPAEEEEEDDDDDEDEEDEEEEGDSGEAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NQB1</accession>
    <name>A0A2X0NQB1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C012g07046 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C012g07046</name>
        <name evidence="3" type="ORF">BQ5605_C012G07046</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1109"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="497"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY16965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1902" mass="209025" checksum="4B3FA398AEBCE972" modified="2018-09-12" version="1">MVVTAWIGKKARSFYWIVFCRLPTAQQPALETQPRRDIRRCLGQHEQAMPDPPGAQAPPPDNPLGGNRASDDESLNTLTREPVTEGTANPPAWSTEATQARLDCEKVMQNTFRVLGIVPSGKSTRRLMVLMHDASTPPSQAPLLARAAQRAVRNDAAPASNVIRVIMDGPGSPRGPVQIALRKHFGLAETPFMFARPEGVVLDPEVEKLFSKCVKLNPIVTKATKRFPIARHMYELVFESDQACLEAAAAGPFSHHGKEMVTELPSASPLNHVVQVRFTLPSSSSATPASVLRQSLDDALTLSFGRAGRTQGYTLMQLQRGLAVDPNGDPMAMTEDGFHCAYLRLHADLFQGSTETQKAALNAALPREIEILGAKYGLRHEFETHYCAVCDRAGHQWGACRKPVSTPATAAPVPGASTSTSTTGFRVAGKNGKHGGPAALNSRASGTNMIQLGPRANPAGAATGNKDDANDDDGGGESVASTEPEGGDTGKETLTRATTGPTKETQTTTAAPVSTPTSPSPSASAPASPLSGGTSESSATSTTSIASTSPRRLRSSSAPGNRRVTRAGSAMILGASGGDGSGGNSSGVNQVKIIRYLKTLRPAPAAILLQEHHLGYNASREGFESAWPGACIRFTPHVLTLIPDGSPLAGHLLSSTPVVFAGAPRLDGRILRSVFRLEELDVEIINMYAPVQEDDRRDFFGLLHFNAPRPKTLRILAGDLNDCPDVSVDRVSITDRAWTPVSHWQTLLSKIAFNALDTVRHVHSCTPAFTRPHYRGRGEERKICSWSRIDYILVQCSWANRLLSASTLFDAPCSDHRPVVATFALPTSNADAEPPLSLPSTSDFISRLNPTVFDDQDFVASIPGVVDEVYRRLEGTAPLGDVYDAALRAVAVAGHARYRSTRADMRRLRAESQSVMEALEARGEHMNEAERDAYAFAKSRLDQLAVKEAQWLRIRAHVPSVDSREGQSASIRTRLNRRSRQTSIVSLEDVDGTETVDMQEALGIASRHAQSLFTPDPARGDPTNARRSLLDPIRAAKCYDDDRSDPTFGRRLPRQARVALDEPFTLLEVEAALKKTDSGRSPGPSGIPYELFKALPTYFAPKLLDLFNSIWEGGKMTASLAEGLVRLLPKNKPGANLKSLGAYRPITLRETTYKVLSKVLVARLNGVLGELLPPAQHGFMPSRRSADAGSHLTLLLEKLKSLGTEVFPEGALLSLDQQSAYDRVDHAWIFDVFEAFGFGERFISLLRALYDPETLGVRYLINGFPTELVRLLCGLGQGDPLSCPVWNITFQPFLDALVRRGIALDLQKVWPGGPRAQLTHLAFADDAVVVVESPAALSKLETLSQTWYEATNGKTNTDKTLVLPLGPNWLRDETAQALPTVQEGESFKWCGYAFFRHGDSKLFWTHVLDRIKAKTRAAGDRTLSPSGKVFYANAHIISTVLHVLSFDIPPQWFIKAAETALTDFVWGGAGRNTVARDFVFQAREDGGLGLISIGDIVHSVALRFWDAVAGSNEAIWAPLARESWRSLVAATRDFSPWGFFSSTARVEKLYRDSTRWGAVVAAARVTVPTIKSELLTLPELLSLPPRLPSLYAEGAKHAYDDADAVAKFAQIADLYWRDEGKGWALVGHRRGFWQHSKEPALQHEHVWSRVGQLLKAKALLPKTALRPARIPLKEAPRPRCFNFFGLTRPFTIRKLRRLVNVVRFPGREDRVKRFRDGTPQSDRKRFWRWLHDRFASAVEQDTHWRLMYDVTPTRKRQHTQGHASSPTCLFCGNDAAVIETVSHYFFECAYSTSFWGGVLRILFDKLGIEDTDVDPSTFTPEQLTMGLPLLRGRGRTTSRWMWVRLACAIGFQRLHLLRWRVHQRFELDKVVAPPSLPSALRAFERDFLSRAGFVPGARDWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NS95</accession>
    <name>A0A2X0NS95_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C011g06568 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C011g06568</name>
        <name evidence="2" type="ORF">BQ5605_C011G06568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NS95"/>
    <dbReference type="STRING" id="796604.A0A2X0NS95"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY12641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="146" mass="15985" checksum="336B58E6BE08660B" modified="2018-09-12" version="1">MGYTRVADSTTDAEYLALSHAGKEAIYLTQLLSELHVRPIDAAHIFTDNEAAAAVAHDPVRTSGTRHIRLREHFVRDMVNRGDISLSHVGTANMVADLFTKALGPKIFGTHCYALGLRTRHPRLKSTSRSRGGGGVRNPLSARLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NXM4</accession>
    <name>A0A2X0NXM4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C014g07640 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C014g07640</name>
        <name evidence="1" type="ORF">BQ5605_C014G07640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY19413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NXM4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY19413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="389" mass="44687" checksum="B236029FCE2A88BC" modified="2018-09-12" version="1">MRNVMFKLELINRDIAACREDLACVNTIDTNKLIEQSTQLQQLAKQRQVLDDRLNSLRTSDINISEFACTLIIASRSLWDLVVQYRQGTEKLRLPCLGGKALGTKAAGLLVKNLNSLRPRLMKAVAMYNDEVKKYAAILANSEDSHSILRTRRVPPSAPEDLNELLKLDILAPLWNNGLYSPFDLENPKGTAPWAYDDDVRVGIPAVLSRARCQQEIKRLGWEVRRIGRWLISRRKRFQQVRQQSLQRDEQDDSAMMMLEQDEERLRNIARRWFSKGGLDHLWECTRQTGEPQVEEWVELRMWRTDDVDVFQRTTAGGLPDHTWPDCINDGMVGESDDITTDHDTLLDISDHSSDDLSHHSVDTTDYGAFSDEINENFDEDDGDVFWGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NYA7</accession>
    <name>A0A2X0NYA7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C014g07591 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C014g07591</name>
        <name evidence="3" type="ORF">BQ5605_C014G07591</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY19213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NYA7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY19213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="485" mass="52826" checksum="4283A2E16BFF5ACD" modified="2018-09-12" version="1">MASFYSRRASYVASWAPQRIYPLQEPSFKPPTSADAPQNFAAPLSPSLSRASATRANSSQDASNADTVLASATSPTTAATVGEPTNRLQAPPMYYPGQAQLARTRAAAAAATGLDPELHASSSTNVASSITATIPWQSHPTATHARAIKRLLRIPLWWSSLTKESEVLWQEWPKEFGGTKMLPSSSTDDEEQRVQGRSSTSVTRSLSRRSGASVADSGIALTPRPTFSSSSEMPLHHSLEPLFKSRIEELDELVPQHLGPSRVWLAALEIINWLWIVALVVALAQGKGKQTKILEGVELTLIVIIVLNGIGVNAVRMRRWALARALRLRSRDWSPLPTTTSTNAHLLNNAQLQGLGEEREDAQMTTDRTRGKDQPTLRWRMMETEGSWWLSYRPIIKCELVMPSVTHARHHVAPPLPLLTDLPALGTAEASRPPPPLSSTPPSPTPPVLSTHAIAEEDQSHQGDAPAYSESLTIVLPPVPFKSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NYP8</accession>
    <name>A0A2X0NYP8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C017g08343 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C017g08343</name>
        <name evidence="3" type="ORF">BQ5605_C017G08343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY19837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NYP8"/>
    <dbReference type="STRING" id="796604.A0A2X0NYP8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16980">
        <property type="entry name" value="VHS_Lsb5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045007">
        <property type="entry name" value="LSB5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789:SF2">
        <property type="entry name" value="VHS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VHS" evidence="2">
        <location>
            <begin position="116"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="351"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY19837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="649" mass="71821" checksum="166A8B3D35D59A53" modified="2018-09-12" version="1">MMKRLFNKKSSATTTATATAPETSSTPPPQQPPPPPPSTFDQRARDAQNQTSQQGPNAPYPAQGRGGQGAFVHVPIAPQAYAIQMVPQLVPVVMQPPRVRDVMNAIGWSCATPQFDFTYVLALADHIGLSTAASKDAAKALRKEFKHAVPLAQERAVRLAGILAHNADLRFRKEVASKKFLAELENLATSRSTEPPVKQMVLRVLSPLAYEYALDADLKPITALYNKIRPDGTPLNGEPLDPEDDLFTPTADPRMQSSRRNHQSRREEPHRMPSVGDQMKDLRSQSEQARGYARMLNEAVAFAKEDEDLTSSEIVQEFHAQCFGAQDYLTQNLQWATVQAEQSRIAADQALAEAPPAEEPSTTTNETRNEHRFSSNNPFAPIVSSPPRSQSTPRRTADETDEEKTFAMLLAAHTEVIEALKLYDDHQHRLSEHYQVQEAEARSRVETRFDRANAGTPDRNGNYHLEVDERDHTRGDGASGSGSGSGDEMSSSAVGEFQQDESSKRESRNPYAAYLSSPPRNNNAGYQIPDSATTTNSKTHDSTADEEHTERSYGQVNLHDLDPFASETTQGSSTTTRPRVDTRASVESTDDVPLAPSEKALGKLRSVSGMDDSPTDYAEQQKRLEEQLRSKYSLQYEEEKAFMRSREGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NYW3</accession>
    <name>A0A2X0NYW3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g02456 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g02456</name>
        <name evidence="2" type="ORF">BQ5605_C003G02456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY40986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NYW3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY40986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="309" mass="33888" checksum="10EA34B5BF1552D7" modified="2018-09-12" version="1">MQELLLSRLIPLVLTPSPHGVRLFFARSDIVATTLLIVQSTFSIAAPLSDKTAHGLEKLISCHTNEIAQNNAFVSCASLYPNATTCSREPLTCSCAAVDCTKTPGTYLSTDAKRCLACNDTHALTCNSTTTLSCQANYTLYPFDNVCCFGKSYSQYIAYGMAKPFSSSQQPFSETKTFIILPPVPVPPVLAYGKTRWKTTMITQTARKSARNEPSPPIRDSDSNALAKRLLPPRRLMRERKRDEEIFFFFLTGAHKLQSFGLAGTATKRAKGGYKATTASSWVKVKPLRAKSAAQIKTRRAPNADSNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NZ12</accession>
    <name>A0A2X0NZ12_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C017g08473 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C017g08473</name>
        <name evidence="2" type="ORF">BQ5605_C017G08473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY20112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="858"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1033"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="879"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="902"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1043"/>
            <end position="1054"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY20112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1513" mass="168395" checksum="4145EC07AF451556" modified="2018-09-12" version="1">MVNSEVSLKHLLATNVPMIFTLLVSINFTETGHCFVYLRDILEEVAELTGLALQEDSCFDYWVVDDAATSSTHSTPCLASCRYDQLAAFTAATDSSDKVLGLTGFVLDIDSLPAEATITLRVYEHIKARLPFVNITTRPQGRVDAPVPSGAPSASKHDLLVREKREASPSDRISGNLRPNTEPDSTDDKLVNSEDHANLPTYSEGRTTMTDLMLEAYPQEIVLDPWRPNGTWGDVLIVRMDPGSSGGLSHMWAFSASSSRTDSKGRWKGPRLDANVEYSKYSKRRCMGVFVCCDQSCPGKRRPHTSLSTASRSKLFQEETPQLVTGRPKKAATRKHLVPNVERPSDELPPCPITSCNGPMRHILCSATIARGQREECPGEIYIWHSGYHLHPPPPVSPAPQASAAELRMGQMTAFPQDPRHRPSASEICPVFDSTRSISRYAPRVGHSKRNGALPDTLMSAIEAVANAGCLAYIEIPGQRQGQPLAEQIHDPDPRKQPRNDGSRSKSKITSNSLTDSETSFGIQTPQMKARLSETIDDRLVEGNLGWPTDAHNTYFRDNWVLLATVCYSPSARRWFPILYSVGNHERSGFYRRHFAHLFQILDDANYSVEDIVNGVTFVVDYSNAQISGLRQAISDWYVARKTADVGRLNVTPNQVSQWTAEAIQIGEKAESGCSFHFIEQVRRFGVRHLSTQTERERFAMLVNTIRNAKSHASIESMAKRTIDEFPVSENWIKWWTRPAIRNVVFKELNGSAERCVATTTNAVESSHWLLIHSCGGERFGPVEGVMRLIDFAKMTDRIESHATDGYVRSSTYHEQGNVRAHIKEIKSRNRVPSSYVSDANMPEPSISFAAPARLAGIGFSESPQGPSDLSKGPATPPLSESTKLPPSTSNRSRQQPKNRSRQGNGPTAQSMASKKGPRRVDYPHKRKIPDPPSDEPRPFPRRIAPSSSIKRPIPNRKVVLPAQISAAHRDESPCPKYHNARNLEAPSGRKYRIPRKRLAFLLSEPESQSEAKRTCTSVFDIPLSMVEIATPKPASTSTSLERASDKLPEDSRSAPRVKFAPPKTSTSTSLGSTIVQLHADFWLRSGEDGPVVIIQGPWSDNSCWIDSTLIALLSVANGLEPWLQCLDILNTHTAYVIPPLGNEMVLRPRPRYLALELWDAIREYTALARKFDMKLAANAIEAYTQLRERMISTVVGMSKERGSHFTTPFKRGSYSSPVTWLETLHSFTVDHPVLPSAVTLNDPDRTLVELHLQRAGYCTACNCIQIEVSPRRQFVVDWPLLISSLHLPSHSLETLSDVLASIVGQPLKLYKEAKNSGRRHHKRNCPGGSYVQFVSITSLPRVIVININNIYPEHSLAPAELRFGVSDQMPEMVWRLRSGVYNINNSHFVTSATVGYGQEAACYHFDAIKGSLARPIGDRNAGGLVSVLFYELEEESLNFLQAFNLMLTRQWHEMWSLYHEPSDPTDIGIKVSSLPPKGTLEEGQNVWKMEDASAFFHECEIVSVGNAKKADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NZE4</accession>
    <name>A0A2X0NZE4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00111 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00111</name>
        <name evidence="2" type="ORF">BQ5605_C001G00111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY44073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NZE4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY44073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="318" mass="34639" checksum="BC7C9D34B49AFC44" modified="2018-09-12" version="1">MMNMLVTLQKMMSAIQTMFSFFGSQLGTLNTTPRLDPSTWSPAPTSASAIAASAPSQSMKEQELQLVALTAELEARRASLRSIGQSAIAFGKTEARVAAEKRVCCFPSLVPCLIANLSALGFVDWIRDNVPYVNDWSNPLESGSTLPLLDFGVCSSPDNSLITSIRRWRTGVIRPAFSQSQKADDDEAYNSFTADDRDVGDSDAWPSNPNDRFKEDRMAEKMRMRNEKVAQRNAELNSHGDEEDDDATAAPLSKRAKGLQVGSKKKKRKTGGTAQVLLGVSATSARDDDEASEKDLPSTGLSDSNAERRRVQIILAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P139</accession>
    <name>A0A2X0P139_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">GPI ethanolamine phosphate transferase 1</fullName>
            <ecNumber evidence="14">2.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">BQ5605_C002g01079</name>
        <name evidence="17" type="ORF">BQ5605_C002G01079</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13 14">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="14"/>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY29724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P139"/>
    <dbReference type="STRING" id="796604.A0A2X0P139"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16020">
        <property type="entry name" value="GPI_EPT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000015">
        <property type="entry name" value="GPI ethanolamine phosphate transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007070">
        <property type="entry name" value="GPI_EtnP_transferase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017852">
        <property type="entry name" value="GPI_EtnP_transferase_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037671">
        <property type="entry name" value="PIGN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04987">
        <property type="entry name" value="PigN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 14" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="515"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="637"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="666"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="690"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="732"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="760"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="790"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="814"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="858"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="915"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="948"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="991"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 1 C-terminal" evidence="16">
        <location>
            <begin position="504"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 1 C-terminal" evidence="16">
        <location>
            <begin position="901"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1039"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1050"/>
            <end position="1067"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="SGY29724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1067" mass="117447" checksum="10401A5A18F62523" modified="2018-09-12" version="1">MLSTRSRNGSHRQDRDIDSTTSSSSTSTRFGGSASLLLLSILFHTIYLNSIFDVYFVSPVTKGVGLRYGVGAEHENGGPGATVGEKLAKRVVLIVGDGLRADKLFQIYNSPPFDQDLPLPSPLQDVPHAYAVPPYANWTTPAPFVRNLIQSGQARWGVSHTRVPTESRPGHVALIGGMYEDVSAVTRGWQTNPVKFDSVFNQSSHAFTFGSPDILPMFAQGASDPTRVDAFSYGEEYEDFSKDAVHLDLWVLDQLKTLLKNSTTNPKLDQQLKADGVVFFLHLLGLDTTGHSYRPHGPEYHRNIRVVDHVISETARLLQDFYDDDGETAFVFTADHGMSSIGNHGDGEPDNTRTPLVVWGKGVASGLVEDEGNDDYSRHWDLRGERLDVDQADVAVLMSVLGGLAIPANSAGRIPLEYLNADPSFKARAGFANAKQVLAEFEERSRFKQAHALAFKPFPELVDDASSGTLSVESHKRQIDALIHAGDYEEATARSMDLVNLGFEGLRYFRTYDWLVLRTIVALGYLGFIVYSAHFVLRTHVYSFDAKVATTTTSPIPRVLGATIFSILSAKFFIERSSATYYAYAAFPCYFWSSILSNRAPLIWLFRSISPARAATGLGATLIVVQMIAQAYLVREYLTYILIIIALAWPLLGMDRAFIRKEQRLVAAWAASCSLLSIFPQLPVEKGENLTIIYAGAVAMFILGLVGREVLEREEVKQATNPSSTIRATHKWLALQIGLILLSLVPTVKSALTLQRKQGLPLWSQSLGWIVLVGSVLVPIIRGRPRQQPFLERLLIVLFAFGPSFTILSLSYEGLFYACFCATLCLWLLLERRIALTRTRNVKDHGESPKINGGHIRMAVFFLTFLHLAFFGVGNVASISSVGAMFQAGCRVKTDGVGALLVQFYLEPVYRLIPVFNPFAMALLLLFKLLSPFVALSAITSVLNKQLGLLPFSLFIIASTLSDVLTINFFFRVTDQGSWLEIGSTITNFAISSLLCIFNTALYLGGEFLLANTEVNSKRLEAVRHDDDVNEIDVVGQGRILPSGSGSGSGSTSRRITRASSATAKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P2F9</accession>
    <name>A0A2X0P2F9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="24">BQ5605_C006g04347 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">BQ5605_C006g04347</name>
        <name evidence="24" type="ORF">BQ5605_C006G04347</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY58177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P2F9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0229">DNA integration</keyword>
    <keyword evidence="18" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="16" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="15" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="16" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="17" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="23">
        <location>
            <begin position="915"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1012"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="1012"/>
            <end position="1022"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="SGY58177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1274" mass="139441" checksum="BD0C209043B61A0C" modified="2018-09-12" version="1">MLPCVLLLKDWHTPANTPVTPPNRAIRDRAPFTKPLQVYSAGPCFRLGPNEPAFVTVHRCEVPAIWPSPSKFRSATCGVTAYEYNGDLFLSLRDVFTGARNMCLWRGLLQWHQFDGLTQSNGLVGVQRKPECAAVTQFLSDKAMDDLAGIDDYRPRAICCANRYEVMGLELDVVEEGAQAGRQTFKKFRQAGSVRKYQIDKLPILEKAIGLHPGHSLFEYEYRAHKPVMVKLRCPTCAAGRLCGTPVAFTQDLIRCNLCGLYLHKLHAEISKEQQRTTRCIICVNVVSTKDLRADELKKLSGTVSLARSCAWAYISEAWMLIKVHDYGVHRDGLGARALAEVPCPEESVNLQLVPGNKLAWSFSNAKQLAGSKNREIYLSLQVPTEAILKKTWGTYASLVKTFNNVEVTSPTERPANSSHQDMSTPLMVTGGTTPIVLVKPRDVDPSCHLRNAGGWSQWIDDVRGALGGDYWNCTLATPVQSPNTRTDLDHANFQAVALLMRSVSPDIRKHIKDGYDHTPAEVLQMIKKAVGTGTVADILIRLQALLDVGPPPTGMDAFAKYQATTIELFNTLSGHELTFEQIVSFRLVHFGKDLYREYYTQTLRQGLDRLPSPTEVLQSLHTQADQTPAPKPVAMVASPIATADKSTAPPFSPCHHCGGPHWNRKCPDNKAGSKGKKTKAPSAPSASLVTAPDISTLVDGPVLGYLTATMSTLARPSIILDSGATHHIVNDRACFTSFRKCKPAPLEGITGEVVNSIEGVGSAIVRSFDGSIGQLNDALFVLTAPVNLFSASRADIGGYDIRLTRAKATVSIADTVCHTGELKNGLYHMQASLVDVAALVHQAGAFPRALVAVPMSVLHGRFAHLHPRALRQLISTEAVSGVSMEVDSNEDLKCDTCQAGKITHHPFPAVASNHSAQPLEQVHMDLLAFDGAVSLGGARYTLVIVDDHSRYLWAIPMSHKSDTFAAFKSWLAKVERSTSRKVLAVRSDNGGKFMSNEFSRFLEEQGITRQLSIPDTPQQNGVAKRPRARNPPARYGALASLRSTPSAFAFSLGDEVVALVANLAEAGIDVSKADRPLSEPEDPFTLPTNDPSTWKEAMRHPHAEGWKAGAIEEFRSMKDDFKVFSVVDLASVPRAATILPSRHVFRTKRDKAGKMVSLKSRIVAQGCAQRAGDFDEMFAPTAKFTSICALVAHLASRGHHIIQAGMDKAYLHGVLEEEIYMRVPTGIEGYDGKCLHLHRSIYGLKQAGRVWNDTINATLANLGYRRLACNECI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P2N5</accession>
    <name>A0A2X0P2N5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C007g04428 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C007g04428</name>
        <name evidence="5" type="ORF">BQ5605_C007G04428</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY60417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0P2N5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051246">
        <property type="entry name" value="WDR48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021772">
        <property type="entry name" value="WDR48/Bun107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862:SF14">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11816">
        <property type="entry name" value="DUF3337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="252"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="299"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="349"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="384"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="134"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="549"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="580"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="672"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="993"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1226"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="586"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="606"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="672"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="704"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1023"/>
            <end position="1042"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY60417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1310" mass="141808" checksum="605D059D15B6EB73" modified="2018-09-12" version="1">MFASPALAQSSAATAPLPRRVTYIIPAPTSSPPLLSLPPVDVDRRGHTAPLYTRAPTGLRDRGAPSTSRSLRSSPHPRHRLAVQALALDLSTVVSRSNGSDEPAGILYTGARDGLLCSWELDLPVKKRRKRYGQPTVDLEDDDYDELGSGSDDDDEREAERRRDPTESETNGILELDDLDRSNRSVSVQEAQNRARSDSIRRGSHASASTARGAKAPAENGVNEALPIEERWEIDDERLNNSPRPSHFRQCIQSHTDWVNDIVLCNSNQTLVSASSDSLVLAWNPHASSRQAQVTPQQIGKHTDYVRCLTSARDAGWVASGGFDRKINLWDLGEGREKPIIDLTPPASIYSLSSTPSGSLLAAGTPERVVRIWDPRSRSQVAQLGGHTDNVRAVLLAEEGKWLLSASSDATVKLWSLAAQKCLHTFSHHSESVWSLFSQHASLEIFYSGDRVGNLCKIDLQGTGEPGEGECVLLARDYCEDDPRPGSQSISQIVAQDDAYVWTAGSSSTVKRWRDCPPRLRRAGAITTRREGMASVVSLSAPLEEVDSNYRPMTPLRPENSLDGRERSAVVSFAESLTSGLTRTVSSPTSPTGASGSQRVAHRPSSLRARVVPSASSARRRPSLSGNNTGSSSQRLFDIHYDSLVPLRSPEASYFSSAFLHRARDPDAATIDSVTSGPSQSFGSRIAASTSPSMHHIPRSPSEVTRENNLARREYMDREDCSEATPLRSSPDGVIEGGQGLKRCELLNDRRHGLTIDTKDEVALWDIIRCECLGVFEPQEVQQLRRRPSDAVSSMSGSSSPVSEAVSSADLLDSVRERIEGEGAVATWCKCDARTGSLVVHLEEARAFDGEVYADEAMHVLADRDPGPEHRIILGKWVLRNLFDSFIEAELELRAGGRTPVPHSRRANGVPNFISLSGLATAMTPAPTRLKTPGMTIALATPALNPVVIPAHAPPSFNSSPIAIRSHDLETIPQSPTPHVFDAGDFARNSVTPGLAKTPAANGRGENDYFSLPTAPNDPTTASPVLLSSPGPLPTPGGSLMGRLRNLGKASKKANVESTEAPAATSVPLEPEMVDTRSAAEQHQHQVLQTVFSRPLTPCEPKDAPTLTYPSDTAIIISEGGFNSSASSVIYRGLVGTGREDVGVLEQKAPLWLLDFLLGNRVIIKEPVKLSFLIQPWTDENGKSDLPELPNSNARLTANRTLRLRKVVGFVADKLNLGSIRGRTSISSSNDLPNPTTMTNTTLTPASPTADAPDPIFESAAVYDPEKELEILVGDVVLPGWSTIASARTFHWKNGGDMVLHYRLKRTGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P4A3</accession>
    <name>A0A2X0P4A3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL49</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C003g02301</name>
        <name evidence="8" type="ORF">BQ5605_C003G02301</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL49 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P4A3"/>
    <dbReference type="STRING" id="796604.A0A2X0P4A3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007740">
        <property type="entry name" value="Ribosomal_mL49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477">
        <property type="entry name" value="MITOCHONDRIAL 39S RIBOSOMAL PROTEIN L49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05046">
        <property type="entry name" value="Img2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="27"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY39968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="158" mass="17120" checksum="DF967277F4AD0AC1" modified="2018-09-12" version="1">MASRTLPSTPAYSYACSYAYSTVVAPASTPVSSPLPIQSEPTASTSTLETETTTTPPTPKSSAPTGNEPEPKLLSYFVRRTAGGELPVYVDVLHGGSKRLTLIRKVDGNLEISFQALRQDLSQYLVGVPNYIKPHARQVVVKGDYVRQTKEWLAAMGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P578</accession>
    <name>A0A2X0P578_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C001g00076 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C001g00076</name>
        <name evidence="1" type="ORF">BQ5605_C001G00076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY43886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P578"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY43886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="71" mass="7720" checksum="2E4E130FD6EC3B06" modified="2018-09-12" version="1">MTSASDESRPIGQLRCHEWKLATPSLASQHSRHPCDLGLPAPRTSSPRFGTCTAFFSSNYTLTTLSPPTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P5A4</accession>
    <name>A0A2X0P5A4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C004g03121 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C004g03121</name>
        <name evidence="10" type="ORF">BQ5605_C004G03121</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY70214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P5A4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY70214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="188" mass="20036" checksum="B67210CA6AC3A333" modified="2018-09-12" version="1">MQSKGAIGTLRWHVGDIVGTGGMAGLYRAIAPTVLRAGILTASQLGTYDHAKHTLMNDFPDTFREGFRTHFIASGVAGFTCSIVSSPVDVVKVGRQDLARRAGFGILAWTSLTRTSVHPTGSNDVGCYWAVPKHSPLRGHGIAERRPVGLLSGSHHVLLAPLAAFGPFAAILRKFPLADRFGTHLTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P5N7</accession>
    <name>A0A2X0P5N7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C001g00365 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C001g00365</name>
        <name evidence="1" type="ORF">BQ5605_C001G00365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY45957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P5N7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY45957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="562" mass="62352" checksum="51FFEFB0DD1739FA" modified="2018-09-12" version="1">MPGDTDTVVSGGTTSIVYVKPRDIDPSCHLRNAGGWSQWINDVRGALGGDYWNCTLATPIQKPNARTDLEHANFQAIALSLSSCNLPQQEEAVRSPVWNKKLWRRVRRWIPPPGILEPLVWEVFEKLGRCEVEATTFQQSGARGSEEICTSTLGPCGGPDGKADDGVRLYSCQRDTNSLEGGIHRNLHQRFPKSGVSPCHVNACTADYVLVHNLTVSPTPPSQFEEAATILTHSPLYSQVGTFNRTGKPFVGHYDLWLTVELHRLRRKTPAFFPRHSATVSDIVNPLLYTPSTETFGIVLVVQSPTAQMRFLIEPYQVERGTLRLEPVKWSPWNLLQNNTPAIQHMQSRLAIDRKLRHDWPAERRGTRIAVFSSKSSDIRDYRALEQVCQRTRHFLQTHQYMGTEMVVAGKCSSHNEHGMLAAKPLLGHKLPVLGRLTEVEVDFSDPSTSSIRAFVATASSAGSSADLGTSSALTRAGTTKGARHCRLCGQTTCRRKGTKLSDDGSVNECDGACLDCGKPFGLTDEMDPNDPQSRRFCRGLTRAEMNGRAWHQKKCHNFVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P5V8</accession>
    <name>A0A2X0P5V8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BQ5605_C005g03373 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C005g03373</name>
        <name evidence="11" type="ORF">BQ5605_C005G03373</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY74633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P5V8"/>
    <dbReference type="STRING" id="796604.A0A2X0P5V8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018823">
        <property type="entry name" value="ArAE_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018820">
        <property type="entry name" value="BRE4-related_DUF2421"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994">
        <property type="entry name" value="ARAE_2_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994:SF3">
        <property type="entry name" value="ER TRANSPORTER 6TM N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10337">
        <property type="entry name" value="ArAE_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10334">
        <property type="entry name" value="BRE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="692"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="748"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="771"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="801"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="837"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="domain" description="Putative ER transporter 6TM N-terminal" evidence="9">
        <location>
            <begin position="105"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="10">
        <location>
            <begin position="712"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2421" evidence="8">
        <location>
            <begin position="856"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="499"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY74633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1125" mass="123964" checksum="D3531DF4C362A049" modified="2018-09-12" version="1">MRAVDTGTKDGADHKQGDTGDFGQHDQETASKPGWRSKVTYPLFAAPLDGTFRHPTFKGLVTTMKIPAESANRYCLLPLFPAPKPPGTHSLLVQNHNRAKWRARKSLARGALVLLGAFIIVLEPKSLTRLGNAAFFGCIAAIMIPANLPVMMVLSVGFLLVFGMCLGWAWSCAAMAAAARARSQALLGSEVKSFRVANANAQNIDALYRVAIFQGQFLDWRSTLIIGVFFVVGSFALGLMRANAPKLMVASIFGTIVMDVMLSYGPLFPSANYTLAYNFLLPTGCFLGIAAAGSVLIFPESINSTWTTSLVDTCLTPVYERIALFSKLLRTPPPSSTSTAWIDQHDAWNNNAMAIAIGVNALLGGMGTMELEASVGRMSAKDYYSLKPLLEELASRSLGLGSLYRGLESQALRTLRDTKGIIDLQAKLQHPIGREAPYLNQLRSKIFAAEDKHAHSIATLLPRFANAVDPLLIAMDEALLGAMTWLSVANTSRWKRLKSDQVAADYEAQRERVAALERAMEEYRTTRRLEIFAPFQKFFDLETGRPRAELKFSPISLMQVLSVSDALVGYATTILNLVARLSELEHKRRVNKLWMPTGLRKIGKLAFSRHRSQIDGVTGDGDDPDQVVIPFSDSASTPIDGAEKEEEELHFFLRQRNEEKKDPDVRAPRNAAQRFGGKLYGIVRWCKTTETIFAIKYAAVGLALWLPQVLKTSAYFTYVNKGLWALITAQTFLSLYAGDQIMATIQKIAGTVVGLLYGMMVWYIGNGRGSNRIGAAASLFVFMLPLLALRNHAPPAQQQMAILTAVTTVLIVGYSWVNGHLATLGGTIGAQLAWRRALLVIIGSVASMIIMLFPGHQSSRLLVRKTHATCIGEIGRIYMALLSHWIAEDRHDAKKHSSEELVQPRPEATSLEFDAFTPAIQKEAREILLAIWAKLIGTTQHIKESRYELSLRGDWPAAEYKSLLRAQVIMMQVLGSLGLGLVRLEPAWRKMLIRSTAFLHPNLISDVSSTFALLSLALREGAPLPQATPGPLLDRLLYHDKRLKTSSDEASNQILHSADGARLGDFELTWTILRDERFGTYSSTIVSLGSLLLTLDDAETAVKALVGEVYMPGYDYLMDRARQEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P791</accession>
    <name>A0A2X0P791_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C001g00965 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C001g00965</name>
        <name evidence="7" type="ORF">BQ5605_C001G00965</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY51118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P791"/>
    <dbReference type="STRING" id="796604.A0A2X0P791"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF68">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="430"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY51118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="469" mass="51636" checksum="346C713EDBDD9D06" modified="2018-09-12" version="1">MISRARLRTFIFTLHQPHDRGFQVNLNGSIIANKGFIRQDGLYQERHHGHHHDFFEPQRLPNVLGVTSSSFVSDYFGRKNALYIIWVVMCASVIVECVAKNWSHWLGAKILAGVGVGAMQATLPPYIAEIAPTHLRGALVNAYSASFVVGRLLAPTVLQQENKRHPLIFRPAIYSQWAFLGVLIILWAIIPESPWWLAGKGNEERGKATLRRLNGSVPGYDVNAEWDIMKATIEHERIAAEKLKTGSFVNIFYSTNGNLLLAGNKDPFRVTVVLACIQIASVILVSLYTAYTSAPLGSLLIFFACSAASGAIGYVYLAEIPTQHWRARTAGFGAAVGACFGVCFSFSVPIILKGAPKWGVRTGFFFCIRGTVSTIIAYFILPDCAQRTTAKIEMFERRSLLGTLPSSTRTCRRHGARTKSLPLEARKPKSATSSNESSLGSSFLSRTLGRCDHQQRCCAVFGAYALGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P7S5</accession>
    <name>A0A2X0P7S5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C006g03931 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C006g03931</name>
        <name evidence="25" type="ORF">BQ5605_C006G03931</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY54919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="758"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="443"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="990"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="1049"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="1091"/>
            <end position="1101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGY54919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1814" mass="199279" checksum="82FF413E8CFA623E" modified="2018-09-12" version="1">MRVVINGKSVLALVDGGSQVSLIQEATCRELGIACTSTVGHSLRSQNDGVKDLGKVCRNVAVGVGGSEVICKFFVSESSSTQPAILLGSPFCWKGLREHHFGQGGADCFVFSSPWTKDRLAPKFNLVASDQFNRELKLWCTIIENTTGQQTGKAQPTMSRKAESLESIGLLTRINWPAWAPAMRLALQSISAFRVATGEQKKPPASQPPNQSLKDYTSLCNDYDAKDAQGRTLIRSHVDENMWFKLKGSAVDASLHQVWTGLVRAYKTNSVPFVGTKTLRAYWNLRYEPGTSVTSFMTEVERLGELCNRQKMLFWKQQLGIGTEELQGFYAQIVDILGEERGKALLSMVLHVDDFAIKTVLMEQLPEKYTFAFREEKDVDLFLEKVRTAYDEDVIMNGANNKEQTEAPASALAAARQEADPGQAPPCNGNCACGQQPHAFATAGQHRGHAGPTRNSYRSGGHGRTGTRVGAKTRAEHYANSDKWGKIVGGKFMCANNQCVNCFGFGHRRAACDSRNPTGDRIAFLQSLDINVPVASHGTYFVEDPVPMSLANRMGASFHFTNYAAEVREQTIFRAATAEAPELIFDTGATTSLVNNKRMLSDYATLDCPIFMIDAAGTRTPAVGRGTLTAEFALADGTTSKMTIADVLHVPNFVVNLISGPSLCKQGVRIEMEEGRCEFSKYGQTFAIAQLVGSKYIFQARLSNLNPTEAQSLTVSMERKETVMGLNIKGEDFDVAKCHGCMQGRGVHANISRGPASRANKPLHAIHADLWGPVRHESFAGEVMVLGLVDDYSRFRWSFPIGKKSSVTALVVEFIQRVERSRDCNVAIFHSDNGGEFVNNSLKAFFWERGIEHRTTVPYAHYQNGVIERGWCTMFETVRIWLLVSGLPLSFWAFAATAFTYVSNRRPTAALPGSTPFEMYHLRKPNVSRFRVWGCVAYVRIAPERRASKIEPPRVKARFIGYAEQGWMFWRPDTNTVFVSDDANFDESSFELHRGNSDDADLREDSPTTLFGDPPTGSLDIDGNDAVEQDFSLDGAGRAQAPGTDDRATAPIAARRAFAPDGNSRDNTPPVGRARAPDREYTPAAPGCERAPGDRVQHSDGQELTPIVPTRRAPAPVVSNGRAPAPVAPNGRAPAPVVPNGRAPAPVAGDGGAPPPVASRRPSPFLDDDADNDPPDPNPIPDGYEPVVPTTERTSELAERWGAPAGSRCRGGAEQQAMFVDLGTILGDVIPLNELPEWEQVLSVVVNLEECNGWTNLSSIVQGSTEGICGIEELEAYQVWTGSPDEPTYKQAMAGEDHEDWSISLMTEYSILNGMNTWDKEATDPPPGVRAIPTKVVLVRKRNDKGDIIKYKARIVARGDLQNHHGETFSPTARIASIRMINVIAHVKGYRRLQFDVNSAYLHGHITEPLWIKLPDGSTHRLRKSLYGLKQSGREWNKVLHAALVDRGFKRMEEDFGVYRRVRNIGGIDRTTLLAIYVDNGLLAGDDNLEGFLNEFGQQFKLKRGEVELFLGMKIATDDASGIMTIDQCHQIETILNNHGFANASAVATPTSDSDQHSDGGTAHLKLNYRQVVGELLWVSGCTRPDISYAVTQLSRHCADPKPEHFRQMRRVLRYLRGTINRRLEYNRHLGIDVTLYCDSDHAAEKSGHRSISGYTVIMAGVAITWASKRQVSVATSSVQAKYQALSAAARETLWICSLLFSLGFPPSSPTIIHGDSTGAIALADHPTSHATTKHIATHYHFTQELVSNGIIELRWIGTKEMVADGFTKGLSRAPHESFVRMLGMCKARALLRATGIRNRDRAHLASSVPSPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P9S5</accession>
    <name>A0A2X0P9S5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C039g11779 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C039g11779</name>
        <name evidence="2" type="ORF">BQ5605_C039G11779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000060">
        <property type="protein sequence ID" value="SGY89939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P9S5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY89939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="71" mass="8015" checksum="65FA5E82D1A11695" modified="2018-09-12" version="1">MESNKDGEFCEVDMEADCKTHRGLGSATSSKDRALPVDPRKIPRFDDAKLASLPEGYRYLAYRQSSAYKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PBI0</accession>
    <name>A0A2X0PBI0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C004g03026 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C004g03026</name>
        <name evidence="2" type="ORF">BQ5605_C004G03026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY69512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PBI0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY69512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="155" mass="17628" checksum="489E6CEF8011E2F1" modified="2018-09-12" version="1">MPAVLSPPRTLDPSPSRPDTSLGLNDLQRLPFDQPQFGLIGLKLFLLLMSRDVHRFDTGEVLGNHAVDHRLDRFFRFGDVPLLTLHRRCESRTSSSFHSCRDFRFFDQIDRFPTPAQPIQSPSAQLALPERQQEPPAREFKIGLPTFSNGFKSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PCB1</accession>
    <name>A0A2X0PCB1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C005g03348 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C005g03348</name>
        <name evidence="1" type="ORF">BQ5605_C005G03348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY74205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PCB1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY74205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="264" mass="29890" checksum="EF9FEE2184DA9E56" modified="2018-09-12" version="1">MNISPAVRNRLRIALPAARTPTGFVSELRAQWPLVVAVGLVPRAEVLSVVRKAGPTVYHDYLTYEHCKDRHSATQLSSIFMDVRHSVIVEQTMSYRDMEIIVLHLLQISDMARVGTWTEVAHFARSVLHDALRYPQLGHLLTSILLYIEHTHPSAHLFEQVCVEIMEQLLDMAFELLDLLDQLDVVDAYANTSEAHALRNAMINLMQVLDELHPLFASLPLYRAFRNEIVRLLAQPRVMGSVGDEVAQAIIETLYDSTDLLSIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PE30</accession>
    <name>A0A2X0PE30_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C008g05018 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C008g05018</name>
        <name evidence="1" type="ORF">BQ5605_C008G05018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PE30"/>
    <dbReference type="STRING" id="796604.A0A2X0PE30"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40128">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40128:SF1">
        <property type="entry name" value="PHYTANOYL-COA HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY79032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="278" mass="31390" checksum="FA225C8B613C49BB" modified="2018-09-12" version="1">MTATWPRPVASLECSLVVAHQLREPTILEPLALRRQLAQDGFLYLRSFLPCELVTIARRTLALDLASNGFLDTSTCLDLTEDPLYINPESIKDKRTPELLNRTDLHRHPDVLSVLEHDSLRRLMRSLLVTPSSDTVGFATPPSTTCLPELRTHPYKWLRAVGPSLYTGLHVDRTYFPTSSFPTLLTAWIPLDNIPTELGSLVIAPDIYLPPMKVGGDGTKSGWIHEKYLEDQTIRWESADMNRGDVVIIDPARCVHMSSRNVASPPTWRISADTRWWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PEW2</accession>
    <name>A0A2X0PEW2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small RNA 2'-O-methyltransferase</fullName>
            <ecNumber evidence="11">2.1.1.386</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C009g05540</name>
        <name evidence="14" type="ORF">BQ5605_C009G05540</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>small RNA 3'-end nucleotide + S-adenosyl-L-methionine = small RNA 3'-end 2'-O-methylnucleotide + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37887"/>
            <dbReference type="Rhea" id="RHEA-COMP:10415"/>
            <dbReference type="Rhea" id="RHEA-COMP:10416"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74896"/>
            <dbReference type="ChEBI" id="CHEBI:74898"/>
            <dbReference type="EC" id="2.1.1.386"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. HEN1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.386" evidence="11"/>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY82023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PEW2"/>
    <dbReference type="STRING" id="796604.A0A2X0PEW2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090486">
        <property type="term" value="F:small RNA 2'-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026610">
        <property type="entry name" value="Hen1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21404">
        <property type="entry name" value="HEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21404:SF3">
        <property type="entry name" value="SMALL RNA 2'-O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="554"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="563"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGY82023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="584" mass="64931" checksum="105CF8A98C793AD8" modified="2018-09-12" version="1">MATNDEERTRSAVTQSGTAESNGAAPSSLSTSPTQTPIAPALCSSSADSSIPRPQLDLHPVFHPPLWLARRTACIRALKREGVRSVVDIGCGEGAVLQMLISPAYHLDSFPDLYAPDPVSHSLSSESRFSSSREAKLEQLRRVPRLNPEEEELHLRRVIGVDILRSSLQQAARVTDPEAGGASPHASRWEECRVELYEGGLESYNQVFEGVEAMIATEVIEHLPPHLFDKFAKTILGMYQPRLVVVTTPNHEFNPYFIATSKSDEDSNRFPDPTGRTNRVFRDDDHQLEFTIDEFQSWAKKVAAENDYRVTFTGVGSLSHYYGSHAPPYTGIPFPPPSLDAHPACRKFASSKSLPSDPSTFFATQIAIFTRIFPNEVERSPRSHKPQPLPFFSPTTESIVEMAPVAAIVPSGVALSSSSTTRPGLTARRPTLTTPHIHVQTHTHRPHPSASEPLGSEKLIKSLKKRFDERQSSRLSLAQIWSNDEMRINCGGIVGSLIDALLEKDEEGEWELEALVEEEGVRGLEALMVEWKGFVERKEEGESVWDRAYIEEMEVEDGHEQGFDEDDGLEDSSDEEGPDLEWEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PG10</accession>
    <name>A0A2X0PG10_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C038g11722</name>
        <name evidence="7" type="ORF">BQ5605_C038G11722</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000061">
        <property type="protein sequence ID" value="SGY92200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PG10"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF161">
        <property type="entry name" value="RECEPTOR EXPRESSION-ENHANCING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY92200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="197" mass="21972" checksum="24DF003D2252CC6E" modified="2018-09-12" version="1">MASAQAKFEYYISQVDTRKGARLRRRTLTTPTPTPAELLGSNCVLMPRGAYLSPFTEGALNKLEQQLNVPKAYAVLGLGAFFSSFIFFNIFAGFLSNLLGWALPAYLSLKALETPGHDDDTQWLTYWVIFGGFNFIESMSSVIVAWFPYYYTFKTIFILYLILPSTRGATVVFNKVLRPVIANNKPATSTTPVANPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PG79</accession>
    <name>A0A2X0PG79_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C026g10168 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C026g10168</name>
        <name evidence="3" type="ORF">BQ5605_C026G10168</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ27706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PG79"/>
    <dbReference type="STRING" id="796604.A0A2X0PG79"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ27706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="327" mass="35971" checksum="07400244838937D4" modified="2018-09-12" version="1">MRARTYCCCAVPMYNTGIYTIIAQFAVISLVTGILSLAAPKMVPSFGGYILGACCILVALIQVFGFFGVYRERPSLYRQYTLWNLLAVLLALGVALAFIILSCVRHSTALASCEGLFATATTTVAQNSAVCNIWMWVQVGLMGLLWIIIAIAEVYFIMLSYGYGKSQRLDHAKYASLFETVREEIRQSGIYSTDRPLTVDSLEPLVSSTQPQPYAAAPHHGRQNSGLRHEIDMDHEDKMHNSELYLHPSPSGYELDGGVYSHDEGYVGAQPYESHWDPTNGGAYQDEYQHGGGYAGHGYAASAVSGYQDASLPKQRNGPNVLHGKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PGE8</accession>
    <name>A0A2X0PGE8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C026g10248 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C026g10248</name>
        <name evidence="3" type="ORF">BQ5605_C026G10248</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ28006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PGE8"/>
    <dbReference type="STRING" id="796604.A0A2X0PGE8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="2">
        <location>
            <begin position="312"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ28006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="461" mass="51483" checksum="116866C8FE27817B" modified="2018-09-12" version="1">MYQHTVVSAAPACGVGVPIRSHVQALCAPTHPTTTSSCAKARKGERAGLESRSNPSSPTFLQGKVQLPPPLRHNPEYWQLLEGSDSDAKAFRENARSYNNALSFTSLAAHCWDQTQVDTIGPPVFRVFGRLYHRLGALIPATCIQRSTLTKLQSMLRTGNRFVREFASAKARAGWDTAKEWVLRLCLPPGRDRRTHNLPTSSTEMAMLICDSDTNTGDRGPQDLILQVHGDRCPGVRPKYQVISSLHPSALPPRYPLLFPAEEDSSHLNIPLCAFNQFGPLFAKRPRRGGRGRREWRTHRLTLNLLAYDLYKRDEYFSIPHCTQRGFLAFVMTDTPRSRPIDSTYLQLDQENLRLATGQGIISLTPDQAGCSVILGSTFKNRPRKNTQHYQDAMVCVVKHGKPSLFITVTCNPEWPEIKAALGPNDQASNQPELIARAFESKLNRLCDDNIFGNKQRAGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PGI5</accession>
    <name>A0A2X0PGI5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C027g10289 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C027g10289</name>
        <name evidence="2" type="ORF">BQ5605_C027G10289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PGI5"/>
    <dbReference type="STRING" id="796604.A0A2X0PGI5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ28224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="444" mass="48898" checksum="717F0BF152D1AB82" modified="2018-09-12" version="1">MPSTSVSHSLSHSTLVRAPREAASGERASARAEGISKAVQMQLNLQSGPQYLGPKGHNIGTEKALDEVIKGVVNMFIPSRAESPFKSRFSLLVFSSRVAPDREETAETTADVVLLTRAVVAHDPTLPNVWAFPSHPVPPVPQAEKPDADADLDTNMNFNANENGSGQHQNDEAEAEDAEDNGCDQYDEDVAKVDLLWAKRYFTHVVPMCETKAEKSSGPWTVNPIACSRIGVARGADNRLNKWPSALELPALVSSTAATCVKERERLARFTSPRPPRRTCRASRFFTHVAAVSETKAAKKSRAKDVSFGRLSALLATPIREHAIGFTLQYNLLKVYVRLLAGYFRWGATTISDVELEKFVFRQLGECGRATLMYEISAGEGTSCKTRAMTITSRRLGPLVLGVFCTDYRTLPAFLPSDESFKGIVPWAEEVALWRERELVQILH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PGS1</accession>
    <name>A0A2X0PGS1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C038g11731 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C038g11731</name>
        <name evidence="2" type="ORF">BQ5605_C038G11731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000061">
        <property type="protein sequence ID" value="SGY92310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PGS1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY92310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="82" mass="9242" checksum="A037074BB1DA6B48" modified="2018-09-12" version="1">MLLALISVVSAEPSPQNKAFKGKLQPHVQSEKRQAPQTPLRIKKKKAPCDECAKLCWNDARNVSRTWRYCSDACGCKSVAYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PI90</accession>
    <name>A0A2X0PI90_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="5">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C032g11057</name>
        <name evidence="11" type="ORF">BQ5605_C032G11057</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="5"/>
    <dbReference type="EMBL" id="FQNC01000067">
        <property type="protein sequence ID" value="SGZ04346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003840">
        <property type="entry name" value="DNA_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF95">
        <property type="entry name" value="HELITRON HELICASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02689">
        <property type="entry name" value="Herpes_Helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="9">
        <location>
            <begin position="362"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="8">
        <location>
            <begin position="1010"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="10">
        <location>
            <begin position="1310"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication helicase" evidence="7">
        <location>
            <begin position="1384"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="314"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGZ04346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1473" mass="165614" checksum="FAAAE82A5C16D3E9" modified="2018-09-12" version="1">MTTIQPILALRHVYEPAASAQASNRAQTPQAHVSIRDNLGPQTAVCTHCKARHWECERSKSTRHFGACCSQGKVRLPPPPQPNLEYRQLLEGSDSDAKAFRENARSYNNALSFTSLAAHWDQTQVGTLGPPVFRTWLIDPAEATNTRLQGPDSTETRIQSSTLTKLESMLRTGNRFVREFASAKARAGWDTAKEWVLRLCLPPGRDRRTHNLPTSSTEMAMLICDSDTNTGDRGPQDLILQVHGDRCPNGRPKYQIVSSLHPSAMPLRYPLLFPAGEDGFHPNIPLCGFNQAGPPIARNREQIDNGVQLRELLDGLGPDEEDEEEDDEDEGDEEDEENGDGERRRSNKRGRGGSTRVSRSQYFAYHLHERDDYFSIPHVTQRLFLEFVIDGYSQVETDRLNYIRLHQESLRLTTAQGITDAVANGLTPDQIGRSVILGSTFKNSPREITQRYQDAMACVVKYGKPSLFITVTCNPEWPEIKAALGPNDKACNRCFGVVLTHTHVIEYQKRGLPHAHILITLAPDDHPLSTEAIDKMISAEIPDPSRYPDLHETVTKHMLHGKCGGNSTQPCMEKDKYGNPRCKRHFHREQNPHTRMHPEGYPLYRRRFRHAVVKGGVIYNDGDCVPYSPYLCAKYNAHINVEAVTTIGAIKYLFKYVYKGPDRAVARVERAANGEGAREDESVRDEINEFVEGRYISATEAVHRLFGFSVGRVWPPVNRLPVHLENQQSVQINPNEPLPLDTPPTRSKLTGFFDLCAAAPDGELTTTLLYTNVPRYYSWNKEKLRWKRRVHDRNVIGRIYTVPLRSGERFYLRLLLEVVMGPTSFADLLMFEDVVYPSYRVACAARGLLADDGEHHICLREAAQIETGDQRRRLFVFMLIHATVANPPALLDRHFASLSDDARYHIERYEDVPVNDQTIRLWTLNKIRLLLAANDRTLAFFDLPELTEDEVRLFDRLEERLPRFDRQQCAQHAEAAHARLNHDQRIAFDECLRAVELDVVDQMRDNNLGPQHVFFLLAPGGTGKTFVENALLDTVRARGDQAIAVASSGVAALLLKGGHTAHSTFRIPLDTLPTSMCPVDRESDLALMLRTTKLIIWDEAPMAHRFAVEAVDRLLRDLRETEEHFGGVTMIFAGDFRQCLPVVPKGTPGQIVDASLIKADFWRDVRVLRLTENMRLSSNADAMDEAQLARTRDFAEWLLTVGDGTANMHPYDKIALPDYLLLPDGQRTAEGLINFVYPGLRTVNKESLEDLIQLFSRQAILAPHNATVDRINAKLLEEFNGDYIEYRSADEVVEAGETGGGMAPELISPEYLHSINPSNFPAHHLRLKEGIPVVLLRNLDPDAGLCNDRAGTTVFIPRVRLETNATGSRQLGFTMRRLQFPLRVALAMTINKAQGQSLDRVGVDLSLHPVFTHGQLYVALSRAMSVDRIKVLLPSRDPADDDDDLQAVDRAAAAATATPNPVFRSVLRAMNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PIJ2</accession>
    <name>A0A2X0PIJ2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C102g13146 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C102g13146</name>
        <name evidence="1" type="ORF">BQ5605_C102G13146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000073">
        <property type="protein sequence ID" value="SGZ10624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PIJ2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ10624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="88" mass="9734" checksum="9937783B598DE023" modified="2018-09-12" version="1">MAYVRIAPEPCASKIEPQRVKAHFIGYAEQGWMFWQPNTNTDLDKADLCEDLPTTLFGNPPTGSLNIDGDDAVKTRFCSQRGRLSSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PKZ0</accession>
    <name>A0A2X0PKZ0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BQ5605_C021g09355 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C021g09355</name>
        <name evidence="11" type="ORF">BQ5605_C021G09355</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000083">
        <property type="protein sequence ID" value="SGZ21315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PKZ0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="488"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="545"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="570"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="735"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="759"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="840"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="88"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGZ21315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="885" mass="98235" checksum="E71E54FA9741290B" modified="2018-09-12" version="1">MVTTGRSGPYAPIQDDDVQVLQSPTQPSTSGAHSAHQSAPHRRHESASTNTAAAAATAMHSAMHSMAQGRRSIGDRYLDDHQDDDEAYELIPRSRSRTPRGNRSSAAAATGKTAADSTTFPTRSSHDRHSQDHDDEDKALADEMDHDEIPLFKDEDLDLDSAMSMVRRIVPESDDPTLPALTFRVFILGTILCILGAAVSQLFFFKSNAPSFSSFFVILIAFPLGHWMTSILPESLSSGEFNKKEHLLIGVLAGSGASAAYAGEIISVQDLYYKTDLGAIGGLLLLLSTQLIGFAFSGLTYRLLVRPTAMLWPSTLVYVTLFETLHGGAKESIKETKDRMKFFTYNFLGIFSWQFLPALVFPTLTSIAVLCIMNNQSLIMRTLGSGYDGFGFLCFSLDWSVIGGTGALYTPFFAQASYFFGLAFNMWVITPLLYFGNFWNARSFDSPLAAHLYNSTFGRLDVLEILNPDLSLNETRYAEVQPILLTPYFALCYGVSFAVLTSAITTVLLWHMNDIKAAFTTRKDAVADIHVEMLERSYDPIPNRYYFSVFFSMILAAIALITFYPMQLPVWGLLLSILMAVAFLVPVGALPNPTPANTTLGLNVISMQPSDPFPDRVLAAETDPTPHLTAEFVAGYLFPGRPIANIVFKVYLTLVRFFHRYMTMVQSIDLTADMKLGLYCKIPPSHLFICQVYGTALGSIVNYSLIRGVINSKRPYLDGTLVDPTGQWSGRKPEIFMSASVIWGLIAPGRFFAGQYSPLYWGFLVGALLPIIPWILYKRTNNRFWKRISIPLILHGSIAPPQMPTNVILPGKLTDLSGFLVSFASQFYALRYRPRWFEKYVYVLSSALDAGTSINALMIYVFGWSTFSEWWGNSRVDTEHCIPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PL58</accession>
    <name>A0A2X0PL58_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C022g09436 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C022g09436</name>
        <name evidence="3" type="ORF">BQ5605_C022G09436</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PL58"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="490"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ22147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="609" mass="64312" checksum="6F709F32C77510EC" modified="2018-09-12" version="1">MDRSSHRFELVKKAKHHATAATVSTTPGRAGVADTRSHRHPAALTPPHRTVDTSVDLSSYGFSFANVGVYTPIYSGVQYTSMSAGKAAAATAAPASAGVTTSPALAAVTTHPAVASTPTASNGGVVANAAGAAGADSSSVAAQSGLHGTTLYAVIAGAGAAGLILISLLTWFCCRRAKKRSGVAAWKKLNEGYSSSAPSTPVRAAAAAVGRPRGSPTGSEALLDEKHNWHDVQDEHAGVHYSPTKPRAPTEPVMGQSGGRFNETWDVNQGQHQQFDMRQTDAQFVLGPNGANDAMARPDMAPHGPEHMSSATSMHSLPANHIISFSDYPEKPMPVLPQALGRWNEGTRASGGGPPGSASNLSVYSADEAVQRISTRVGDQRLENRLMLAAAAPSTLPTVVQSRPETVVDYSDAYGGELDEFVEEQWDDVHLPQRNGSVLTKSTFGTSRGPPPTTRREPKESGARVDSKPLRDLEETFASLATRNNSFKRANAPPALNPSSSSTEPAAAGNNLHARSAAEQRLVSEMGLPSPSLSAMSETTPPFNTSSIVAPSRMVIPTIVEPNGFMPLAQQNASYDQRYRSTTESIYGCYDDEDISRRSQQEPEVRNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PPB9</accession>
    <name>A0A2X0PPB9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BQ5605_C048g12357</name>
        <name evidence="16" type="ORF">BQ5605_C048G12357</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="FQNC01000110">
        <property type="protein sequence ID" value="SGZ30426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0PPB9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056521">
        <property type="entry name" value="MARCHF6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCHF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145">
        <property type="entry name" value="SSM4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23113">
        <property type="entry name" value="MARCHF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="649"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="789"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="833"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="879"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="944"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1164"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1203"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1242"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1292"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1355"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1401"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="15">
        <location>
            <begin position="73"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="451"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="476"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="488"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="499"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SGZ30426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1450" mass="161168" checksum="E4F77E0A63933E52" modified="2018-09-12" version="1">MERWQDYDQNVRPTAGPSSSSSDAQLHQLGPGHDHPTPNEGTIPRSPSTSSDHPPTSMADAARDAPGADADDQDQVEDHVCRVCRSGAPEDGALFWPCQCAGSMKSVQHSLPQTVPVPLASAYISRFPFRYVHESCMNEWVRVSKKTKCELCRTPLHYTSIYPAHMPSHLPPKIVLRHLVSSLLSSLALVLRLILVALLWLVVLPYAIESIFKLFICTADGLGIFSLVITTRVTPVRLAGGTYMTLLPRTTHSNSGQTIEYFVNSTLCYLKQNLTSPASSTTLMNMTTGLSSLIQTPLDESSDLVHTATQSTPNWIGRLDKIDYIRTMIYGPTPRSKIAWDVIFDTIASDVFKGQVITSIVIVLFVIGFLVREWILTNAPPEIPPAPVPVPAPAPAPAAAAEAPVIPELIVGEERAQGLVHMEIDDELRGPQYDEMWRHLERTLDRLAAVDPSVNLPPRQTEQVRGVTSDARLVHDEEDEEEDQDYVDSEREDRSGESESSDEDDEDDEDEEYNGVHIPGLTGDYVPGLDDPNGGPSYIIRRVNPEGSQPPPVQPAQEEARPRPPILRGELAPAPRAPAANIAAREVPPPPEQQINNERAMIVAADAANAPILPDDPPPNDDDFAAEDLFDDFEGVLEAIGMRGSFSTLLQNICLMMLLVSLCLAIGLWIPLSLGRVMAGLDAIRWVVMPLRVVRWFSDPVFDKAFEVVMWAPRKGVRFVDTMVQDAGDGTILGKVLAKFGGVASHSPVVANSTVAVASTKPLAASSVKMTFKTAVKHYKMMGHAEDTFHRALCTALGYMTFLLGGAGYLHITDNEYSRSVNRAIREGISQQLTLLKVCFFVAVEIILFPASCGLLVNLSTYPLFPGASLATRLNYLHAAPFSGFFLTWLAGTIFMFSFSAAIDAVREVVRPGLIWFIKDPQSHDFHPIREILERSSWTQAKKIFTSMLLYGSVIFLSLSTNVFFLKYCCPTILPLNWLSTRSFSVPLDLLIYRFVVPFTIGLVEPRSIAKTWWTQWARRSAKALRLSHFLFGERNLDEEGTHVRRTWRARILLLKAPVPPRPVEGDDRIRDTTFDDEFFSSSSSTRPVIFQHDGGFGRVPALDTVRTTPNRPILIRVTSQGFPLTPRGEQVIAEQVSEMATTRKKDAYEVVYLPPAFAVRVGVWCYLAWLAGSAALVGGVVGPLVVGRYLLSKIASSPPHDFYAFTLGAHLLILFAYGISHASQFRPSRQTWSTIRIFSMTILLAGILTPLALGLFVEAYVVLPVKLLQTHRYIAKLLPTPSAPSASMSTIHVLPSWSLGILIQHLLLLLLRSPLILPSTSPLRLAQSRAKTLWLHQARPAALSLLLKDLYTPLFLTLLTSLLFPTCLAISLHRLLLHFYPSLSYIPSTHFEPYPITTCIQLTYFIHSTLFILITFGWGFRKWWLNWLGRRRELEYLVERRLRNYESLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PPF9</accession>
    <name>A0A2X0PPF9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="7">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C040g11913</name>
        <name evidence="8" type="ORF">BQ5605_C040G11913</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the tannase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="FQNC01000118">
        <property type="protein sequence ID" value="SGZ32770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PPF9"/>
    <dbReference type="STRING" id="796604.A0A2X0PPF9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF15">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015801394" description="Carboxylic ester hydrolase" evidence="7">
        <location>
            <begin position="27"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGZ32770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="635" mass="68670" checksum="A5F9A64681C3F677" modified="2018-09-12" version="1">MVGFGTSPSFLTAAAVVALCLTGVNARTRRHGRSAHVGDADVSTRCANMASVKMPNMSIYATEHYSANSTFSPSGPSRSYSDPVPGLAAFCRFGAEIQTSSQSKVRHSREWHLPDAGLLLWLSRFFGTRELLQIRFEVWMPDNWSRRFAMVGNGGDAGSVNYPDMSVPLTKYNFAVASTDTGHSGWANDGTFAISNPQSQIDFGHRAVHLTATYSKKLIRTYYGGDGAKYNYWIAADVPSSLMTAPNRSGCSCGGRQGLKEIQLYADTFEGVLAGAGAHWLPHLHGQTYRLNAFVNKIGSTGYLTAANYATIGTEVLKQCDVLGQDKLKDGIITDPVSYLASSCLRKSKPLSSFLSFLLSQQTKCSPKLEGLLCSAKGANKATCLSQAQIETMYTIWADWKSSTGLATGPGGTNYFPGFQPGSESYSSGFSVTGTPFSVAPDYFNYQVLNKTSVQPFTVDSEADFEKLLKIADDTDPGQTNANNPNIRDFLSRGKLMTYVGLADTLIPAGSTLLYYDRVKAKLGNVDESYRLFAIPGMSHCGGGNSAFNLGQASQSDISLGGNLQSANFTAKYDMILALIAWVEKNQAPDSLVGVNYVNGDKRQGVAFERLMCPWPQLGYYRDGDTTKASSFACK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PPH8</accession>
    <name>A0A2X0PPH8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">BQ5605_C049g12439 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">BQ5605_C049g12439</name>
        <name evidence="15" type="ORF">BQ5605_C049G12439</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13941"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.28"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>dihydroxyacetone + ATP = dihydroxyacetone phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15773"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.29"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; glycerol fermentation; glycerone phosphate from glycerol (oxidative route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dihydroxyacetone kinase (DAK) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000111">
        <property type="protein sequence ID" value="SGZ30711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PPH8"/>
    <dbReference type="STRING" id="796604.A0A2X0PPH8"/>
    <dbReference type="UniPathway" id="UPA00617">
        <property type="reaction ID" value="UER00669"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050354">
        <property type="term" value="F:triokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019588">
        <property type="term" value="P:anaerobic glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.340:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10440:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase, DhaK subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10440">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.20">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050861">
        <property type="entry name" value="Dihydroxyacetone_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629:SF14">
        <property type="entry name" value="DIHYDROXYACETONE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629">
        <property type="entry name" value="TRIOKINASE/FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82549">
        <property type="entry name" value="DAK1/DegV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="DhaL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="14">
        <location>
            <begin position="10"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="DhaL" evidence="13">
        <location>
            <begin position="429"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="394"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="428"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="394"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SGZ30711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="651" mass="69646" checksum="2435B68CF260EBE8" modified="2018-09-12" version="1">MTMSKHILNDPKTLVNDALSGLAFLNPALTYNPATMTVMVRQADHDKVHLLCGGGAGHEPAHAAFVGKGMLSAAVSGNVFASPNAAQIEAALDRLSNSKGQLIIVKNYTGDVLHFGIVKERWAATHLGKDSVRLLVVGDDVSVGRAQGQLTGRRGLAATVLVYKIAGALADTGASLDEVEHLAKLITKRSGTCGIGLDHCHVPGTEQAEGYLQQDELEFGLGIHNETGVRKQKPIPSANRIVEDLMKWLTDVEDEDRAFLDFKNDGKDEVILLVNNLGGISEIELSVVVNEASKWLASKHITVERFVCDRSPFPCPVSDHVIALSRVLSGAFMTSLNLPGFSISLVLLPREPVATPSTFTSNLCFDKDLILEMLDAPTEAPAWMWHYKGRPEAHVEEEKDDQKNSKKRKTEVDISGSDQVKGPAPTDAKLFKSAIEAALQELVKAEAEITKYDTTAGDGDAGLTLKAGAEALQTKISSDVIPTDKDVVATLVGISAVVEKEMGGTSGGLYSIFFAALSKGVLQAAKDKGENKATSEVWARALELALNTLYNYTLARPPSRTLVDPLAAFIITFGSDPANFDNAFNQAQEAAEATRTLVAKAGRAAYVDQDKIEKANVPDAGAWGVLKILQGVKAALGRESSSTTMTKRGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LNW7</accession>
    <name>A0A2X0LNW7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxisomal ATPase PEX6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Peroxin-6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C011g06386</name>
        <name evidence="13" type="ORF">BQ5605_C011G06386</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0LNW7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19527">
        <property type="entry name" value="RecA-like_PEX6_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000109">
        <property type="entry name" value="Peroxisomal biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000039">
        <property type="entry name" value="peroxisome biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056995">
        <property type="entry name" value="PEX6_4th_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047533">
        <property type="entry name" value="RecA-like_PEX6_r2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF9">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23315">
        <property type="entry name" value="PEX6_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="694"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="975"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="326"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1257"/>
            <end position="1311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGY12094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1311" mass="140887" checksum="F4B087995D6B65B9" modified="2018-09-12" version="1">MNSGSAGSGTLGHETGYDFLTDRPVKLIVAPSRPSVSTAQSQVSERGAMSIQDDLLASIKLHDDTHADEVALSDALWQCLRDLSAEDDDQAKSGHGASISSQLVTEARFAIALKPRTRLVQARNSSTTFGSLVVNASKATGKNKADQQPNTNVVYVPQRLLEQHPAIFGSALKSASTSASSSSTSSVSLGVSRVRLIPLSDLILIAYNSNSYDYSVTNKDEFLQSLGKHGRILRSGEVLSSTSARGQALSWTIAIAEPVLQGVLVPGSTRFLVLTPTDEPASLLNESSSPNGHGDHHDLHSLDDDDGAFDIDESFLAASVLSLPRLDGTSTPISPRDLSDLAPSNSPPSPFPSHGDGPLSPTRSALSRSQNQRALVQAQALQRPVDSSTLVPQPTEGEDETLWAFLGSRDLSRVGLFSGDWALVESEGSSVLTSERRLVRVFVSDELQNVIDATGVPVALFAPTLLHTLPSKTVTLVPAALPFQTSFPLASSVTVARVASPRSVHRVYQSLFLDGLKGLFKDRQRILRKGDVIAVGICEDMARFSEGAAAEDEDEVELPASLNVPTAVVYFVITSLELSPPTEVRAEGGDELTELLDLGAFGCHVDPRMTKLVQSGVEHSLVPDVEGYLRIGELLSQRWPRQSPPVEVYPRCSPIVDSFAAKSDKAALEEGTPTWRLLEYVKASLRPGTSDYDLHLTVLVKGAHGSGKRSLVKSVARSSGLHLLELDCYDLIGESDVKTEGHLRARIDNALSCSPCIMLLRNIEALARKSQALETGQEPAMTTVLKECFATARQGWKTSGFPVIIIATTCDIEKLPRGVLGAFKEEIAIEAPNEAERLTILRSLTRSSVIAPDVSLRALAVQTAALVANDLVDLVRRAGSAAAERALASIDASEADARSLRVEDVAHAGLELTAVDFNKALDKARASYSESIGAPKIPNVTWDDVGGLTNVKSDILDTIQLPLEHPELFADGLKKRSGILLYGPPGTGKTLLAKAVATSCSLNFFSVKGPELLNMYIGESEANVRRVFQRARDAKPCVIFFDELDSVAPKRGNQGDSGGVMDRIVSQLLAELDGMSKGKGGSNVFVIGATNRPDLLDPALLRPGRFDRMLYLGVSDTHDAQLKIIQALTRKFKLDPNIRLEDVVALCPYNYTGADFYALCSDAMLKAMTRKATEIDDTINLPSPAAKLNLNPPYSNGIKLTPQYYLAEMATPAEIEVLVLQKDFEAALAEASDCVLVPSVSKAEMLHYKTVQQKFSSETMNSNEKMAEKEQQQQQSRIGSKAVGSGSVTIAPPVELSAAEQRRMAKGKGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LQZ7</accession>
    <name>A0A2X0LQZ7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C013g07132 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C013g07132</name>
        <name evidence="7" type="ORF">BQ5605_C013G07132</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY14856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LQZ7"/>
    <dbReference type="STRING" id="796604.A0A2X0LQZ7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF37">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR GPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="460"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="481"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="508"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY14856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="523" mass="55923" checksum="FCA26E33A79E1F14" modified="2018-09-12" version="1">MTHPRPSSESSILIRRNRRVLLSPTPELRIPPIYISLFLKKGGRLGVPSGPATRSQRMPTRYLPLGDKHAGVIAVATCASLSVLSILLLVLYSAWLVCHHFRRSASERASTSRGIVFLTSNHGFFFLSLIAGDLFQAIGFSMNWTWIARGGLPSPVNETCTTQAIFVLSYTPPTPVVYGSIASVWIVTGIMAGIGPARFGSRESPFYGIAGGWCWIAQSHQIWRLWLHYFWVFLVAGINLIAYSIIAFQIVRRRRRALSSSNIFGTTAAPTKAGPNLGGSNRIAAIMLIYPLVYLITILPISVYRFALLSGKTPPIHYALAAGCVFTLSGMINCLVYASTRNIVSFSSLRRKGSAVTGAGMIQFTQGGMEGLGPTISVRRPSMADFQASMLSGRSGSVSGSLLGSEERGVRSVNLMGTSSSGSHRGESLGVLSGGGGGGVGARSMKGATKISTGSWNDSLEAVPESQHGSSGATLFHTHPSGGTQIPSPTSISHGTTPNTTPPTPPEMDLKDLSIFESRYDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LTE9</accession>
    <name>A0A2X0LTE9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="23">BQ5605_C011g06400 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">BQ5605_C011g06400</name>
        <name evidence="23" type="ORF">BQ5605_C011G06400</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LTE9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0229">DNA integration</keyword>
    <keyword evidence="18" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="16" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="15" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="16" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="17" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="22">
        <location>
            <begin position="565"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="267"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="SGY12138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="775" mass="84764" checksum="A0C6CEB3FC3D26C8" modified="2018-09-12" version="1">MSQPAWGNSDNIGGMASTPPPPPSSSMSNQPFDVAPATVVTLTKEQYNALVKNQRPAQAQEDDAISMRHLLPPDDSKLTEANYVDWALAMSTTHAREVCAYLRKGQHDPSWPPAFHTRWEDYAARALASSLTVTTKATIGPLIQTGGSAHNCWLALAARYVPSDAQAYSTLIKDYFSMPPCPPTWSGFHAWTNRAMVLVNHLQMAQLDLEQAIAVRALDDLPPVFDSWLTTFYAVKVQDNKLPHVEQIFASMETVAHTLCHDPTPALAAKPVAPTKPSASGKKGRWDRSGPAPSNCPACGQGKHWVDKCPDTRKRVKYFELRNAMKELQGTSSSQAAAFVATKEASKDLNMSFFSSPTFVSFGAPNIFLLDSASACHVVNDASFFNTPLAPTSHILQGLGGTVKASGVGLVKLVSDTGTEFTLNNVIYAPESPANLVSVRAFDRKGVRITFERGQAELRTQQGCIATASAIASHVYKLNASVQTPSPGVIHMLVTTKSHGIPLLTLHHRYGHASVQTLKKLVASGQVEGLDWTYSDLECVDFTCNVCLASKAHRLPCPPSSFHASSSEPLALVHSDVLSFPEELFSHKRYLVTFVDDFLRKTWVYPIGHKSKVLQMFKDWLMEIENKTGRRVETLRSDNGGEYVSTAFNGFCVACGIRRELTIPYMPKQNGRAKRLNQSIVEGTLALLIDLGLPRTCWDKAAMCYIHTKNLSPHAALKGGVPNSFGCRAWATMPAHCRAKLDPKGIPLVFVGPSRLGYTVQKTDNFNRCILKSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LTI6</accession>
    <name>A0A2X0LTI6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C015g07883 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C015g07883</name>
        <name evidence="25" type="ORF">BQ5605_C015G07883</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="416"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="656"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="759"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="665"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGY17770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1303" mass="142139" checksum="2F2CFF1DA4B202FB" modified="2018-09-12" version="1">MSNPAISTRHATCATREAGRNGSTTSKPNARTDLEHANFQAIALLRRSVSLNIKKQIKDGFDHTPTDVLKMIKKAVAAGTVTDIFIKLQALLDAGPPPSGVDAFEKYQANTIELFNTLSGYNLTFDQVISIRLIHFGKDLYKEYYTQALRQDLDKLPDPIEALQTLQTQAESTPAHKPVAMVASLTATDRSSSTPSAPCRHCGGPHWNRKCPVKDKKSKASSAPSASLAAAPDISTLVDGPIRGYLTAAMSTLAKPSLILDNGATHHIVNDRACFTNFRKCKPAPLEGITGEAVNSIEGVGSAVVRSFDGSIGQLHHALFVPSAPVSLFSASRANAAGYDINLSRGKATVSVDGSICHTGEITNGLYHMHASLVDVTTLIEQPVNMEVALNADLKCDTCQAGKITHHPFPTVASNRSAQPLDRVHMDLLAFDGAVSLGGAKYALVIVDDYTRYLWAIPMSHKSDTFAAFKSWLAKVERSSSRKLLAVRSDNGGEFLSNEFSSFLEEQGITRQLSIPDTPQQNGVAERANRSITEGVRSMLHQSGLSHALWAEALATYVYVKNRSPHSANSGVTPHTRWHGSKPSAGHLRVFGCRAWKAATTEARSKLDPRGIPLVFVGYDLESKGYRLFDPATRQVFKSRSVTFFEDEFPARREGITAAHAPVAGDDDDDDDDDDEVVVLPDQHANQAPPDQAELPAALRFDAPGPAWQPPVGSRPRNPPARYGALASLRSTPSAFAFSLGKEVTELVADLEAAGIDTSTANRPLSEPEDPFSLPSSDPTTWNEAMRHPHAAAWKAGAIEEFRSMKDDLKVFSVVGLSSVPKGATILPSRHVFRTKRDKAGKMVSLKNRIVAQGYAQGPNSFNNTFSPTAKYTSIRTLIAHSASKGHHIIQADVDKAYLHGVLEEEIYMRVPTGIEGYEGKCLRLHRSIYGLKQAGRVWNDTINATLASLGYRRLACDECIYRHEDAGGDHYIALYVDDLLFFGPDLGEIDRVLDQLDTLYGVKRLGPAEWVLGVQVVRHDDGGISLLQRQYLLDVLARFNMSDCNPCKSPMEASLQLSPEPDTDSADNAIYRSMIGSLMYAVVATRPDLAHSVGYLSRFVGKAGDTHLEAAKRVLRYIKGSLDLGIHYTRTSAPLLGYEGYSDSDWGSDIQTSRSTMGYLFKLAGGAISWSSRLQPRVACSSTEAEYLGLSHAAKEAVFLRSLLTELGLDTSSPLRLLGDNQGAIALTQNPVFHARTKHLRMLEHFVREHVRNGEISVTYIPTHDMVADIFTKPLPRVVFQRHCDAIGLRRISGQEQGGVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LTW2</accession>
    <name>A0A2X0LTW2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C011g06570 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C011g06570</name>
        <name evidence="2" type="ORF">BQ5605_C011G06570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LTW2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="1">
        <location>
            <begin position="199"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY12648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="287" mass="32385" checksum="2BE60C1AEFC25977" modified="2018-09-12" version="1">MRGIIPLVNKEQSNWAECLAVCEYAINSSLNVATGKTPFELVLGYTPSLAPLARVDGDDDLPSVEELLARRFQACKDARDQLAISKVRQAAQSNKKHQDEPSWAVGDLVLLDSSDRQKRLHTRKRRAAKLMDPFNCPYRIVKAQPEISSYTLQLNGDDAAVPFFHTGKLKTYHKNDTALFPNREPARLGPVDVGGEPEYIMEDIVDERIRAGKQQYLVLWLSWPSDSNSWEPAKALEDTEALDRWERRNEDLGRQAPLRLLWPTLGAYLKIDQVLSNTGQISEADSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LUA2</accession>
    <name>A0A2X0LUA2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C010g05867 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C010g05867</name>
        <name evidence="2" type="ORF">BQ5605_C010G05867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LUA2"/>
    <dbReference type="STRING" id="796604.A0A2X0LUA2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016022751" evidence="1">
        <location>
            <begin position="22"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY13449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="297" mass="32728" checksum="C5BFD2403DB5898A" modified="2018-09-12" version="1">MPFEPQGFLAVLLSLFMTCHPYYTIKGPFMATRRSLRAAADELEEGSEETPASPQPRLAVTELVTPTLSVKDDYDEGTTVSVRHLTDQKIICDAESRQDSVMLAIGVEFDCSEKRSLSAVGAMGRSRLIGYFRTCGLPRLDLITRIGGGRTATVWSARWSKTGKQTTLARSSAVVSAKYAASIAREYFVHTRIVPYLSPAAHAFYGLYCSGSDGYEYVFVFEDVGKEISETEWALNAELRDKAEAASQLIADEGVIHDDVYSRNVVRRADGRIFLVGWGEAQHENFAPDEADGGNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LUA4</accession>
    <name>A0A2X0LUA4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C013g07110 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C013g07110</name>
        <name evidence="2" type="ORF">BQ5605_C013G07110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY14814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LUA4"/>
    <dbReference type="STRING" id="796604.A0A2X0LUA4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="1">
        <location>
            <begin position="40"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY14814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="139" mass="15772" checksum="DD440C10393FBF30" modified="2018-09-12" version="1">MIRFSPHLLAPVKERTTRLRSSSSSPLLPLDYFVNHAKSLSLYRSFIRATRNLGTLEARWHTIKWIRTDFERYKGLVDSVSPRSSITHLWEPILNLLAHDSQQQAKTLLSLGARQLKQLNSTASLIGIDGSKFRGTKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-11-27" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LV67</accession>
    <name>A0A2X0LV67_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mitochondrial intermediate peptidase</fullName>
            <ecNumber evidence="4">3.4.24.59</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">BQ5605_C017g08530</name>
        <name evidence="15" type="ORF">BQ5605_C017G08530</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.</text>
            <dbReference type="EC" id="3.4.24.59"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.59" evidence="4"/>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY20211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LV67"/>
    <dbReference type="STRING" id="796604.A0A2X0LV67"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06457">
        <property type="entry name" value="M3A_MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000055">
        <property type="entry name" value="Related to mitochondrial intermediate peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033851">
        <property type="entry name" value="M3A_MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF79">
        <property type="entry name" value="MITOCHONDRIAL INTERMEDIATE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 13" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="14">
        <location>
            <begin position="304"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SGY20211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="806" mass="90658" checksum="2E4BCC1EC1C131DB" modified="2018-09-12" version="1">MKSRIPSPRVFLRCSSLHPRTTLARVVPRAIARRSLSSSSSSLPATHNTPLHQLFDVPLNSYASSPAYSSNPTGLFLQPVLTTPSSFPVLAHRTTLRAQILVQRICDPSTYAQKNFQDLAQAEHAFLAMVKDLDRLSDLLCGVIDLAELVRNVHPQKEWRSEANEAYEGLCAYMNELNTHVGLYQGLKSLHSILPATTPQKSPELFAAYAVTTPFLRDFEKSGIHLPSLQRTKFVDLSTEILQLGRKFLINAGEPREGVQVGVKELEDGFGNAFARRILGEEAQANAVGVVDPISWEGRVLARQHPSSELRKRLYLATHRAPDQSHLDTLDDLLIKRGELARLVGRNSWGQIVLEDKMAQDPENVMGFLDALDAHNRPLAQKDLQRLQHVKRQIEGGEGRIDAWDRDFYSDLVNQRPSPIPDLAPFFSVGSCFFGLSKLFERIYGIRFEPEEMRQGEGWDSSVRKLRVVDDQEGEIGTIYCDLFAREGKQPGAAHYTVRCSRRVDDDRPEADFGGKEFVDLPSGERVYKAQAEEGLLDVPSVEWNGREGRYQQPIVVLVCAFGMEEEWQKATRTCLQWHEVETLFHEMGHAIHSMIGRTSYHNVSGTRCATDFVEFPSILMEHFITSPSVLDLFAHHPASGRPIPRSILNQMLVDRSTFSALETTSQIMMAALDQRYHSGIVKDGFSSRDQLATVMKRYHVLPLSSDVQADWHLTFGHLFGYGATYYSYLFDRAIAAKVFGQKFAEDPLNREKGEELKKSVLRWGGGKEPWGMIGELVGEEEVMRGGKRGMVEVGRWGIEEAKQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LVX3</accession>
    <name>A0A2X0LVX3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C012g06873 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C012g06873</name>
        <name evidence="6" type="ORF">BQ5605_C012G06873</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LVX3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF76">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="514"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="283"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="861"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY16443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1066" mass="114974" checksum="783AF0952D167C04" modified="2018-09-12" version="1">MNTLLLDDGPSRTSPAAGMVASTSDSPLTSTMDRGSASIGKSRGAGKQVFIQQLRKRLPSTSAPHSPASASDDDDESDDEGRRSSGYGREGGQAGEGRKAKRARVSVSCKECKLIQSYLLPIKCVEQRRKIKCDRQMPICGPCDKRKQPEACTWDIFSGLTGAQDGILPPSIAKSSDLDRALARIEHIEHFLKRALPPNLAVFTPYSSRDRAARVALQQLEEGGPPRSGAGQVGNSSEPAPGGQEEAFWEVEQAALNLENGVFGATPKDGSSDCKAVASTSTTMPAAVAGTRPPLLSNPSAGGRPQRGPIPAGSHRPQSTATTSRFGASSIELTKALTTIVATERPSETLSRAHLNVEFDATSSDIDKARSEELHQLIRALPIERACTNYLVELYFGSVAWLFHHLHAPTFLIELDAFWRLCDEGREDEVDPCWLGLLLSVICVALDSTRASRSPLSLDPPKADQSSPLESFTPEEIEVLPERWFAASQRALRLAEWETIPRIRSIQAGQPSQMAVWLAASIRLAQAMGLHLLGSNPEIMPPDDPAFPPGKCSIKRETAKRLWAVLVYQDWLGATSKTRCYQILPLHFDTDDPLNLNDSDLSSIDWKVNPAPDSVLTDSSSDRVRVAMARQVRKSFDEIVLMRSYSYEKVLELDRGYKMILESLPDQWTLESSTNGNEQPMLRFQRHFVIEGIHNRIFRLHRPFSTRGYSEAKYRPSTDACLKSARIVIISTHNIADATRDIWYSYSHVMGAALVLFNDLFMSIDQDASDSEIDSKRKALLLALEIFTKGSGNICSPSLQVVVQQGAKIMNGLFRAEESRRTGRAAQALLAASGGDATLDGEQDDTPVESFADVLRRISRSLNTQSAPHRGTPPPTRNIPKKSGHLPGGLLPSSTTRYRALPGAPGGFPQSPGTPLSSAFPLDPNSTSPLPIVLGGTAGGAGPVGGNQYMGGGQPYHEPATPTVSAFETNPWPFPTGYGAAEDDLSAQFFQELDLSSAMGLDGSVGGGVGVDGDGFWAAPPSMGTDGGLPTFGSTSTAGMVPQGQRPWDSGMQFTINNMGDVGGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LWC1</accession>
    <name>A0A2X0LWC1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C019g08980 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C019g08980</name>
        <name evidence="4" type="ORF">BQ5605_C019G08980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY23771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LWC1"/>
    <dbReference type="STRING" id="796604.A0A2X0LWC1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015903834" evidence="3">
        <location>
            <begin position="27"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY23771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="175" mass="18986" checksum="3FE7D2631CAF316A" modified="2018-09-12" version="1">MTHSCLSTTPLATLALLLPLITPARAQYGYYYGNGRPYGQRIGIVGVLALDAIRAVAVVVLLVILVISFLLRRRRARAFKQAYPVQAYQPNQVQGQPSASNNNGTFETGQQGQQQQGYQTQPFHQPPPGYSNYQADQSTYPQPHQPQYAPPTSLPPAANPSSHYAPPSGSPPTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LYA4</accession>
    <name>A0A2X0LYA4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">BQ5605_C014g07482</name>
        <name evidence="17" type="ORF">BQ5605_C014G07482</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12 14">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY18819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LYA4"/>
    <dbReference type="SMR" id="A0A2X0LYA4"/>
    <dbReference type="STRING" id="796604.A0A2X0LYA4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000008">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 14" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="15">
        <location>
            <begin position="50"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="16">
        <location>
            <begin position="249"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="SGY18819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="450" mass="49219" checksum="469944FD7EFA92FB" modified="2018-09-12" version="1">MREVLSVHIGQAGAQIGNSCWELYTLEHGLTPEGLPLDASTGPRGGADGFSTFFSETGSGKYVPRSVFVDLEPGVIDEIKTGDYRHLFHPETLITGKEDAANCYARGHYTVGKELIDTTCETIRKLADNCNGLQGFFVFHSFGGGTGSGFGALLLERLSQDYGKKSKLEFAVYPSPRMSNSVVEPYNAILTTHTTLEHVDCSFLIDNEAIYDICRNKLGVQSPGLVNLNRIIAQVVSSITASLRFAGSLNVDLNEFQTNLVPFPRIHFPITCCSPIVSASKASHEANSVAELTMSCFEPNNQMVKCDPRTGKYMACALLYRGDVVPKDVNAAVTSIKTKRTIQFVDWCPTGFKLGICNEPAQCVPGGDLAKVSRSLCMLSNTTAIASAWSNLDHKFDLLYSKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYQEVGMDGGDEEEVGEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LYQ9</accession>
    <name>A0A2X0LYQ9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01413 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01413</name>
        <name evidence="2" type="ORF">BQ5605_C002G01413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY32810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LYQ9"/>
    <dbReference type="STRING" id="796604.A0A2X0LYQ9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.700">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY32810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="444" mass="47612" checksum="1DE89ED4BB801E40" modified="2018-09-12" version="1">MQSPILRTRLTAAQLTLSKQNVSRRTLSTQRATQVPPVAGQRPIIVNTGRPVVGAPQPHPVPNPPRAAPGGRGPNVPVIIGIVAVGGGLIWYFNKPAEAKREIRQLENKAETAFDATKDKTEAALEKTKYKVESVLDSAKDKLPADRSTQSQAKADEVKSKASGWFSSAESDAEKAKREATAAYQDTKSVVGKKVEEVKQEGQSWLSWGGDKAAEAKSTAKDQVADAKYSAKQNGEGIKAEVNISQRSFPSPTLLQCSDPFSPLCSVQQSKSWFSWGSAKADDAEKATKSAARDAEYKIQSAADSANRTAQEAANATKRGYYEAKDSAERELDATRRSTRDVAQYAEDGARDTANAVKRGAEDAGRVAQEKAEEAKQAASSWFSWGSKKADEAADVAATKANETKDAAVGAGHGVKDNVKDGLLWAENKVESGAQRAQHETKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZ94</accession>
    <name>A0A2X0LZ94_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nitrate/nitrite transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C016g08104</name>
        <name evidence="10" type="ORF">BQ5605_C016G08104</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY20599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LZ94"/>
    <dbReference type="STRING" id="796604.A0A2X0LZ94"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015113">
        <property type="term" value="F:nitrite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004737">
        <property type="entry name" value="NO3_transporter_NarK/NarU-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00886">
        <property type="entry name" value="2A0108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23515">
        <property type="entry name" value="HIGH-AFFINITY NITRATE TRANSPORTER 2.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="457"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="525"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="79"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY20599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="549" mass="59030" checksum="16CCCBC888DDC0F4" modified="2018-09-12" version="1">MSTIVREKEVSSSASSAHFDSQGVVEAAKGVNSNNATLNYNEPPSFRIASLWEKPVVNPLNGKSQTLPMFNLANPYTRNFHLSWLGFFVAFLSWFAFPPLIPEAIKTDLKLTTAQIGNSNITALASTLGVRLIMGPFVDRFGPRKVMAALLLLGAIPSGLAGTITDYKGLYIIRFFIGILGATFVPCQAWTTAMFDKNIVGTANAFTGGWGNLGGGVTFVVQVALFQALLNDGLSSHSAWRAAFAIVPCPILIFVAILCLVFGTDCPAGKWSERHTMPASSISMSRGHLTTLDASQRRIAEQKMSDKEAGKVTVQEAVDDDVAEQLHDIDVAVAEKPSIAGTLKIATTPYTWLPSIMYMTTFGFELAVDANLANVLFAVHKSPSFGQLKAGYYASIFGFLNVWTRPLGGILGDMIGKRWGPQGKKYATLTCGFLQGVVSLAYGLHTLHAFTHGNKKGPSLGFQIGLIVVMAIFNEMANGLNFSLVPHCVPYSNGIITGIVGAAGNLGGIIYALMFRFHPQQGYAAAWWISGIFAMVVNLVVIAIPPPKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZZ1</accession>
    <name>A0A2X0LZZ1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BQ5605_C016g08112 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C016g08112</name>
        <name evidence="12" type="ORF">BQ5605_C016G08112</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY20643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LZZ1"/>
    <dbReference type="STRING" id="796604.A0A2X0LZZ1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF21">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="887"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="916"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="961"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1006"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1051"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1077"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="11">
        <location>
            <begin position="125"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="60"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY20643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1122" mass="121454" checksum="5482FC1844862570" modified="2018-09-12" version="1">MSPSQTFSSGGDADSFTEKGDLDAASKAADVEKGARPHRTFATLSSMPTLPVARSTHFGAHPLSRQNHRTLSRTNSISLTSGPVRTNPHHKLPVVYRTLSIQVTETRQGRETYKKKAIQDLAELEWHTLPTEEVCTRLGVSPVVGLDTQVAQRRLAKNGKNVISPPPRNLPKKIFFYIFGGFGSLLAGGTVICFLSWKPLGNPNPQTSNLVLAVVLVIVIALQAIFNAWQDYSTGRTMASISGMLPSDVLVCRDGNTFTIPASDLVTGDVVKVTLGSKVSADLRLIECSADLRFDRSILTGESNPISGTTVPTDANFSMESRNIALQGTLCLSGSGIGVCVGLGDNTVFGRIAKDATGERPVKTSLEVEISHFVLIIGSLAFSVALLIVIFWAAFLRRKHPDFINVPTLLIDCVSVAIAFIPEGLPVCVTLSLTVIAGSMKKKNIMCKTLATVESLGCVSVICSDKTGTLTQNRMTVVDIVVGDKIVSTKEAQALAAGGGELSISRRAVMTLSSIAGLCNDAAFGSADTNLPAHERKVNGDATDTGLFRFAEDMSRVAELRALWKVVGKLAFNSKNKFAIKVFTPFDAEKLDATLPPLLASDDYHPEDCLMLVKGAPDVLIKRCSTYMDIEGQILALDDAAITSISNRQIELAEQGKRVLLLARKVFRRDQANATNLDDEDTLLELNKDLTIVGMAALVDPLRDDTAETVRVCRGAGIRFMMVTGDMSVTAVSIARSAGIITTSKVHGLADLPRDLPEGSIAPYDANKALDAPLRSIALSGPELITMTASQWSQVMSFDEVVFARTSPQQKLQIVKSYQATGCTVAVTGDGCNDAPALKQADVGVAVAGGSEVAMEAADLILLDNFSAIVVGIESGRLCFENLRKSILYLLPAGSFSELMPVLVNVFFGLPQVLSNIQMILICAVTDVLPALSLCFEKPEADLLLRKPRDRKKERLADARLLGHAYFFLGVPETLTAMTGAFYFGFHRHGVHFSSLWLNYSSVVDAGLLSKAQSIYFFNLVLMQWFNLLSTRTRRLSLVSQNPLGSPRTRNYRLFPAMVAALLFAIAFSYIPWFQKVFGTTTVGIEFYGLPLAYGAGLLMFDEVRKAINRRYPNGRLAKMAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M0N8</accession>
    <name>A0A2X0M0N8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C018g08688</name>
        <name evidence="4" type="ORF">BQ5605_C018G08688</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIM50 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY25986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M0N8"/>
    <dbReference type="STRING" id="796604.A0A2X0M0N8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FCP1 homology" evidence="3">
        <location>
            <begin position="309"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="16"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY25986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="584" mass="65469" checksum="EE4F6C02C9B8D8C9" modified="2018-09-12" version="1">MRRVWCASLIDTMAGKKKKGSPRLIRKQKQEAKRMDQRPGAVGAAPSGRLVPERDAGRWQVSHQHQQQQPIQQQYMPFMPHTRFYPNGMPIPPYAPMASPPPQFSQSPYAPPVFNSASIGGQTELVLPRPRVWVKECTGYTELNYPSFDSNPRRGYSPHQPLINGTVSFNGIHYNPAFLPQLQRGFFEPTPPMWDQHQRWGAPYSPFPYAQNHQDYQQQYPQANQPYPQSQPPNYQNAPTHPAPAQGRGQGNERPHARPRARSPPALTSGSGLYVRPQRRLKRARDAPPPEPTEAYLAIAQEPSSVLPEPTSPPCLILDLNNTLLFRKKRDASGSRSPIARPYLATFLNYLISQTTDGSPRWILAVYSSARAKNVLALLAAVGLVDHERANSVQGGQSWEAEEGDALALVWSREKMGLTPKEFDLDVETSKDLDPLWRVLGGELGPRRTVLLDDEEGKAATQPYNHLPIEPFLLDPSSLPPSSPPRWASLPRGFRTPSVDLPRASATEIASTHPCGQDEALLSTIYLLEQLREQTNIAGFIRNGGLKRTDIVEEGKRIAWARKFCRAQDIPVTRDWDPNWFSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M249</accession>
    <name>A0A2X0M249_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00040 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00040</name>
        <name evidence="2" type="ORF">BQ5605_C001G00040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY43632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M249"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY43632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="53" mass="5985" checksum="174617574743E184" modified="2018-09-12" version="1">MQSRGSAASKFKDGGPDTTPPSMRPPRSHRWPIRSWVRAVGRPKCRTKPRPNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M3F2</accession>
    <name>A0A2X0M3F2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C002g01802 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C002g01802</name>
        <name evidence="8" type="ORF">BQ5605_C002G01802</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY35790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M3F2"/>
    <dbReference type="STRING" id="796604.A0A2X0M3F2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051228">
        <property type="term" value="P:mitotic spindle disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071630">
        <property type="term" value="P:nuclear protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19519">
        <property type="entry name" value="RecA-like_CDC48_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000004">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.10:FF:000001">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000003">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000012">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000048">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="7">
        <location>
            <begin position="27"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48" evidence="6">
        <location>
            <begin position="127"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="239"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="512"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="718"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="785"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="728"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY35790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="821" mass="89959" checksum="0BE2FD88D4CB5FE7" modified="2018-09-12" version="1">MADDPSKAIKTDDAATAILRPKKSPNRLIVDESSSDDNSVASLHPATMETLQLFRGDTIIVRGKKRKDTVLIVLSSDDVEEGKIHINKVARNNLRVKLGDIASVHACHDIKYGKRIHVLPFDDSIEGLTGDIFNVFLKPYFLEAYRPVRKGDTFLAKGAARSVEFKVVETDPAEYCIVAQDTVIHTEGDPIKREDEEGNLTDVGYDDIGGCRKQMAQIRELVELPLRHPQLFKSIGIKPPRGILMFGPPGTGKTLMARAVANETGAFFFLINGPEIMSKMAGDSESNLRKAFEEAEKNAPAIIFIDEIDSIAPKRDKTNGEVERRVVSQLLTLMDGMKARSNIVVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILRIHTKNMKLADDVDLEKIAADTHGYVGSDVASLCSEAAMQQIREKMDLIDLEEDTIDAEVLDSLGITMDNFRFALGTSNPSALRETVVEIPTVTWDDVGGLEKVKIELQETVQYPVEHPEKFLKYGMSPSKGVLFYGPPGTGKTLLAKAIAHECQANFISIKGPELLTMWFGESEANVRDVFDKARAAAPVVMFFDELDSIAKARGGGGGDAGGAGDRVLNQILTEMDGMNAKKNVFIIGATNRPDQIDSALLRPGRLDQLIYIPLPDEPSRISILKAALKRSPIAKDVDLNFLAKNTHGFSGADLTEICQRAAKLAIRASIEADMKADRERKAKAATMSEEEQAAAAEADATMDVAEEDDPVPEITRAHFEEAMSFARRSVNDQDIRRYELFAQNLQQSRGFGSSFKFPDSAEATGADAGAGGAAFTQPEEEDDLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M3Y7</accession>
    <name>A0A2X0M3Y7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C002g01730</name>
        <name evidence="12" type="ORF">BQ5605_C002G01730</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>UTP + L-glutamine + ATP + H2O = CTP + L-glutamate + ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the CTP synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY35139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M3Y7"/>
    <dbReference type="STRING" id="796604.A0A2X0M3Y7"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097268">
        <property type="term" value="C:cytoophidium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CTP synthase"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003792">
        <property type="entry name" value="PRK05380.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="CTP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550:SF0">
        <property type="entry name" value="CTP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP synthase N-terminal" evidence="11">
        <location>
            <begin position="2"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase" evidence="10">
        <location>
            <begin position="320"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU810713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY35139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="616" mass="68255" checksum="0AE6BCA4961D9805" modified="2018-09-12" version="1">MKYILVSGGVISGIGKGVIASSTGLLLKTLGYNVTAIKIDPYMNIDAGTMSPTEHGKSLRGEVFVLDDGGEVDLDLGNYERYLNVTLGRENNITTGKIYREVIEKERRGDYLGKTVQVIPHVTGAIQDWVERVARQPVDESAKEPDVCIIELGGTVGDIESAPFVEAMRQFQFRVGIDNFALIHVSLVPSINGELKTKPTQASIRDLRGLGLTPDLIACRCPCPLPLPVREKLSNFCHVPTDQVLAVHDVNSLYHVPLLLQDQGLLKYLQKRLKLSDVQTDAPRLARGVKLMTMWKELTLGHDRLFDKVNIVLVGKYTALQDSYTSVVKSLEHASLQCARKLIITWVEASDLEREAQTERPKEFHAAWQAVCTANGILVPGGFGFRGTEGMIAAAKWAREKKVPYLGICLGFQIAVIEFARHVVGIKEAHSAELMETTPDPVIIFMPEISKTHLGGTMRLGLRPTQFQPNTEWSKVRQLYGGAEMIWERHRHRYEVNPIYVQRIEEKGLLFTGKDEKGERMQVAELKDHPYFAGLQAHPEFCTRPLNPSPAYLGFIAASAGCLDEQLERQKSYVPPHPESHLRIPTPLPSPRVASEGTFASAQAAAATKGMATLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M4F7</accession>
    <name>A0A2X0M4F7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitogen-activated protein kinase CPK1</fullName>
            <ecNumber evidence="3">2.7.11.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Stress-activated protein kinase CPK1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BQ5605_C001g00840</name>
        <name evidence="16" type="ORF">BQ5605_C001G00840</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Responds to activation by environmental stress by phosphorylating downstream targets.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="3"/>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY49954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M4F7"/>
    <dbReference type="STRING" id="796604.A0A2X0M4F7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07849">
        <property type="entry name" value="STKc_ERK1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000040">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000073">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008352">
        <property type="entry name" value="MAPK_HOG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01773">
        <property type="entry name" value="P38MAPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="13"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00081481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SGY49954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="358" mass="41027" checksum="9E8E391A3FC202FB" modified="2018-09-12" version="1">MSQDRLFNVGADYQIIDVVGEGAYGVVCSAIHVGTHSKVAIKKITPFDHSSTSASRQVFCLRTLREIKLLRWFNHENIISILDIVRPPTLEAFSEVYLIQELMETDLHRVIRSQELSDDHCQYFLYQTLRGLKALHSAAVLHRDLKPSNLLLNANCDLKICDFGLARSALSAETEAVGFMTEYVATRWYRAPEIMLTFKEYNRAIDVWSVGCILGEMLSSKPLFPGRDYHHQLTLILDVLGAPSLDDFYAISSHRSRDYLRALPFRKKRPFNTLYPNANPLALDLLERCLTFNPKKRITVEEALAHPYLEPYHDPEDEPTAEILPPEFFSFDKEQLSREQLKVLIYEEITSPPRIGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M4W7</accession>
    <name>A0A2X0M4W7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C001g00960 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C001g00960</name>
        <name evidence="5" type="ORF">BQ5605_C001G00960</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY51096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M4W7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054293">
        <property type="entry name" value="DUF7029"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055647">
        <property type="entry name" value="DUF7223"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22974">
        <property type="entry name" value="DUF7029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23865">
        <property type="entry name" value="DUF7223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016088168" evidence="2">
        <location>
            <begin position="23"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7029" evidence="3">
        <location>
            <begin position="92"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7223" evidence="4">
        <location>
            <begin position="290"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY51096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="646" mass="68642" checksum="D53A34721A1D75BC" modified="2018-09-12" version="1">MPDLSWFHSALLLSCLGTLALSQPINLTTYHLYDSSHAAQGLVHPDALRGELVQTPSALLNALSLRDAELFVWASPKGTRGTSQFAIMQMETHEKQKVLNMQRFSQLLAAVKCKPSQVTIQFVTKAAFEAASQLWSAVNSGTIRHLQLFTSWKGCYTDGGNLKPFHLTGVSFDSEKLAATLTGNETDWKTAAHTFIMSSGEHFDETPPTADGSSRPLLTRSPIFTKAGKEFAKEFKSVAKSIDKVENKFLKKIRKELHATLANKHKVLRIAFDKSYTGTKTFSTPGKAASLNGSVTCTGCGPTGSLVLHTVIKVTLGEKPTVKLTMKPQNLGVSLGLAMSAKSDFPESFGIETPLLEQTIPAAGFKIPEIASVGLVASLGYGISVSNFKGNLNVAKNVSVSIPDGAKLNLLVSPSNDEQSKLGGSWAPVAQSTPMHISGFGSGEFAVGLGISLSLKMEVLSFEITPAKITLSGPSIGFEFGVSSKECGPYPSVGSSHDPTYYITPKLGFSLSVGSDLNVDSGTWGLGIPIPDSGGPNVNSSHGTGGSGGGGGGTNPPHPSSTHTNPDQKDSSQPAVKTRSVNKRHNHDPIGASKISISVSKTLYEQSFRLHSPICFMSGLHQRRPLSNHGRKDEPDGGTRRLSNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-07-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M5T8</accession>
    <name>A0A2X0M5T8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00099 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00099</name>
        <name evidence="2" type="ORF">BQ5605_C001G00099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lcsJ thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY43989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M5T8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051490">
        <property type="entry name" value="THEM6_lcsJ_thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475:SF4">
        <property type="entry name" value="PROTEIN THEM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY43989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="336" mass="38222" checksum="5165115FF65B5E79" modified="2018-09-12" version="1">MPTLSTVSRFLPSWSTVVVGFILNYALKTSNTTVHAQWLRRAFFTLLWLNWRSLPFIWHIGTSASYLSRQGSVSLRLGLNPRPVLADLFGQIPLLHLRLRLYGIDKVFAIAKDPFDTKVITRGTATWDASDWNMHLSNSSYAKACDVARFKWLCDVVSSNSGLEKDEEDIWSPLAQTAFYFHREIPIFASYEIDVHVVAWDDKWLYYVCRFTTPPKNKKTSSERTLNCVSLCRSCFKMRGSRLSIPPARVLSISGVGPDRSNWNRAMGLREKGKGKAWLKYGGELAAMKAGKLGMNHVLVGEEGWDQDGMQAFEERRKEGLKVVERFGDVKGWESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M6B8</accession>
    <name>A0A2X0M6B8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g04216 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g04216</name>
        <name evidence="1" type="ORF">BQ5605_C006G04216</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY57069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M6B8"/>
    <dbReference type="STRING" id="796604.A0A2X0M6B8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY57069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="101" mass="11200" checksum="BEEEBDC11C958572" modified="2018-09-12" version="1">MSSGTRDGPPHTDNVARRVKLELPTLNAGFKSRDVTRWLAGCEDAIESAEWNYGGKIAAVHLIREAGCKMEGEGADWYIDCRDKVKALKSWPDVRVEVAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M6H6</accession>
    <name>A0A2X0M6H6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C001g00339 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C001g00339</name>
        <name evidence="1" type="ORF">BQ5605_C001G00339</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY45802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M6H6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY45802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="157" mass="16513" checksum="D5BF96F4D704355B" modified="2018-09-12" version="1">MGATTIFGRAFGSGTGTPFGFARSRSGLALVVTARLGACRHAQERDIGQRGKVVDDGSVQTVEEIEDDLFAGARRSEIVVVVMIVPRTHWGTQGSANVRSAEAVRQGCAHGKERTGCGRVREGHVACNAVAINVSAVFGLDTEGVPNLARCDARFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M8E3</accession>
    <name>A0A2X0M8E3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C006g03885 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C006g03885</name>
        <name evidence="3" type="ORF">BQ5605_C006G03885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY54536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M8E3"/>
    <dbReference type="STRING" id="796604.A0A2X0M8E3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10207">
        <property type="entry name" value="ASKHA_NBD_Arp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="517"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="601"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="517"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY54536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="648" mass="70939" checksum="DACFA20D350764A9" modified="2018-09-12" version="1">MSSESSRPTPYAPTATPSRPSRTRESSSSTHLTRQKSSHVLLQTPAPARTTTTSSSGKTSTPAGGPVTSASFSPAYQTSIRSRHSLYGIEDRIVLDLGSRIWKLGFSGEPRPRVCLDVTSLVEEEGETANEEAGGLLWALEGYQVDETRERIRYERLKKGLRRIWYTNLMTDPKQRKIIISENPLLSTQVKYMIAKVLFENLQVSSLDLFSKVPSITFASAPVLALLATGNVTGLVVDCGHLETTVLPVFASRPLFPSLLSTPRASSLLNARLKALLLEFASYAPPPTSFNSSTPPTIGRVPECILSEQVVEEVKNRCCFVGKRVEEEGHEEEIEERERPDLEGSALQKMEKRFAKRTKATTLSWRLPVSTAKAGRTTSTTPGTLTGQGWLLIPGWVRERAAEIIFESGDGGEDERSLQEVVLEALLKLPIDLRRPLARSILCTGGTMMLPGFIPRLRHEIDEVLRLSQTAPLGSKPITQGKDSATRRAYRARLDKLRTTPRYASLTPLRNQISILNDSSNSFNDTETAEDGEGPKRLGPRSGSAPAWSASLLNWVGGSLAGCLKLGGVEEVKREAWDERQIEREKGKEGSERAEVGVQLGEEAEEEERMAGGTAPLGPTLGMGVVVNKVEEGSEGRPRVSQWVGLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MCA3</accession>
    <name>A0A2X0MCA3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C008g05063 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C008g05063</name>
        <name evidence="5" type="ORF">BQ5605_C008G05063</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MCA3"/>
    <dbReference type="STRING" id="796604.A0A2X0MCA3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030307">
        <property type="term" value="P:positive regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004083">
        <property type="entry name" value="Raptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029347">
        <property type="entry name" value="Raptor_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848:SF16">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14538">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01547">
        <property type="entry name" value="YEAST176DUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM01302">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Raptor N-terminal CASPase-like" evidence="4">
        <location>
            <begin position="161"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY79170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="714" mass="80537" checksum="A8B6ADA6A642A4B3" modified="2018-09-12" version="1">MAPLQLTPIKASTSATPPDEYEPSQDRQAEDYQDDDDDYDSQDDEDDDGLNRDPDYDDGPLQSYAHVQRGQAQGASDSNMRHGFAEAYSSEEYLTVRPGSSERTSFVVMSADIFPSEYPVQALEKSYFLYWTETRHERAGLTKPPSSNPADHKIDWRNRDRIRTAAAVLVVCLRIGYDPPDVIKTDPCAKLECWVDPHALAKDKAMERIGKNLQSQFENLAATPKTRYKQYLDPPIEDAKKFCTAARKTAKNERVLFYYNGHGVPKPTPSGELWLFNKQYTQYIPVSLSEIVAWLGSPTIFVWDCSAAGNIVTKVQEFAIKRDAELAKEAAAAVAAANGHPQTPAADGSFPVPEAKPQIPTVPFRDTIQLGACLAHETLPMNPDLPADLFTSCLTSPIEIALRFFLLRNPLKMGQLDLDMLLKVPGKVNDRRTPLGELNWIFTAVTDTIAWNSLPRDLFQKLFRHDLVVAALFRGFLLAERIMRFYECTPISVPALPQTHNHPLWDSWDLAVDMCLAQLPKLLDHEKRWLDSLPPHPLMMPDQPAPPQPPGPPLPYEHSNFFSEQLTAFQVWLDQGAVSKRRHPEQLPVVLQVLLSQAHRLRALILLCRFIDLGPWAVNVALSIGIFAYVLRLLQAPASELRPVLIYIWARILAVYENCKEDLLKQTYPPTRTADLSPYTYFVNILHPSTNSQLPVSNVSEHRAMCRLPQVERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MCD4</accession>
    <name>A0A2X0MCD4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C008g05093 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C008g05093</name>
        <name evidence="1" type="ORF">BQ5605_C008G05093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MCD4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY79277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="48" mass="5565" checksum="244BD40A36B696F5" modified="2018-09-12" version="1">MPPFLRGRWGKLATIASTSEVYYSIFCWNVHQFRMRPPQILPAPLISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MCK9</accession>
    <name>A0A2X0MCK9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C013g07244 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C013g07244</name>
        <name evidence="2" type="ORF">BQ5605_C013G07244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MCK9"/>
    <dbReference type="STRING" id="796604.A0A2X0MCK9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF589">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE [ACETYL-TRANSFERRING]]-PHOSPHATASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="86"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY15094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="484" mass="52351" checksum="F131508E5ABC3BD5" modified="2018-09-12" version="1">MRCRCEPTQLVLVPPRTRTRARRSVVSPHSVTTALASPLWTSGSPTVTATAFGSTPSPVSSRRLSTVQQFRTANGNIKVDLKNKHTIGIAQSRGERPYQEDAYSVASLSLPQHALKRNLINVKQGAGWNNDTLEGFAKENEEGQERLRQVACFGVFDGHGGNQVAKYLEAHLAKRLEDCSVSDITPTISKYRALGGYLRRYRGGILDRFRPNAGSNIIEIDPKAKTPSVELTTAVSAAAVASVESNELKLGLDDMCVLTFLMIDNEILADKTKAKVGSVATLALLHSLDLPHALPFYASQQLSLTIAHLGDTRAILASSSSGRAKALTETHHADSRIESERLRQSGTGLVTDSFGESRWGGTLANTRGLGDGEFKTLGVIGEPEVHSIVLKAAEWSFLVLVSDGVTDVMSDQEIVDLVRGVKDPHEAAKRIVDFAEQVGAEDNLTCLVVPLLGWGKMGGVDVSASRREYRLGQAQGTSSRQKRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0ME15</accession>
    <name>A0A2X0ME15_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C005g03451 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C005g03451</name>
        <name evidence="1" type="ORF">BQ5605_C005G03451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY75827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0ME15"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY75827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="361" mass="40663" checksum="EE63CAF19092C689" modified="2018-09-12" version="1">MHNCQIQYPKQGQGLVRLIFMRHKENADRAEFSSYRPITLRDHIQPVLLPPQQHGFVKGRRSAYAAFHLRLLIDELGARGIEFPDAALLSLDQSSAYDLVVHDWVFAIFDALGAPAALLRTLRMLYSDDSTSARSIINRFLTPPSGDTELAYANLIERLEATLEAVQHRWLTHHTVPFTSIVVKKLDRMLADFARGGKHRHDYGEEVVFSPKYKGSVGVMRLGDVVDSIAARIWDVLLGGSDLAGTSAHIRPTGMGVPEERRDIYAYLSTFKASAILLQEHFIRPQLWQLIQDEYEGKAFINQHCLTLIPADSPQVDAALLRTHSALDGRDQSQAVLVDEDLALVFVLDELPKLWSNEMFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-11-27" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MEF5</accession>
    <name>A0A2X0MEF5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C039g11821 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C039g11821</name>
        <name evidence="3" type="ORF">BQ5605_C039G11821</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000060">
        <property type="protein sequence ID" value="SGY90665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MEF5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="2">
        <location>
            <begin position="230"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY90665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="566" mass="60300" checksum="B3A2AD0E7956727E" modified="2018-09-12" version="1">MMIKNRRIWTGSTRARAPAVTTTSATPLPTSKGKKCSPGFLNKKACVKVCPDKLLADTKAANCVPCPAQATCKQGLVTTCQSGWLINPSKTACIACPTHAVCRNGVVSSCDTGLLINAQQTACGACPRRTICTGGKITSCQLKQASYLTLPKPVSPAPLTASAPTVLSRRAGQFLLRGLCLKWCQDGLQRRPGRHNQIYDFVNHIVSHSHFDRVFDNVVDHLTRGDDSLYHAEHHFGLFNDQELVYALDYFLNDQLVAFALDHDIISLKGAPTKATKICRNILVTSSSISEADGSTFLGRAYQAPSTAPVAGTASIPLQYPDHTSSLTTGGFMFLSKALAGTPPQEFTILWDTGSPLFWVDGTTCVDGTCNVTPFRDTVTVGGGRLPFSFKLSLREFSLTHALAFGGHVQTQSPGWTRGATNGLFGMSFNGPNSGHKYEATVNADAIVDSGTVYVVMVDAVAAAAFASIPDWGYYQNSTASKMYTYPCATPPVFTFSFPGGSTAWTISEDTLNLGQVDDTNCLASVMGGADAAAGGAGHILGDAFMQNVYTTFDSDNARVGFSQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MFJ3</accession>
    <name>A0A2X0MFJ3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal recognition particle receptor subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C005g03510</name>
        <name evidence="12" type="ORF">BQ5605_C005G03510</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SRP receptor beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY76720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MFJ3"/>
    <dbReference type="STRING" id="796604.A0A2X0MFJ3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019009">
        <property type="entry name" value="SRP_receptor_beta_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09439">
        <property type="entry name" value="SRPRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY76720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="397" mass="43082" checksum="5CF053277C39B19A" modified="2018-09-12" version="1">MATPVHVAGAASPLATPEVAPLIAMGTLSPMRIFVSLAVLLVFLLVAFFSPRNAPTKRKAQPKGTSTVVLAGPMGAGKTALFYKVRPDTKNVQHMDLRLTWNCTNQLLYNQHLMTHTSMEENEALVESKWTTASNDGLDEKGAKEVCASTPICLIRPNCNSVIRRLQHPQLGPEKLQRPCHLVDTPGHPRLRTRSLTQFLPTTDRVVFVVDAINGTSGKSVQETGEHLHVVLSLLSELSSLTHRDPPPLLILLAKSDLVPSKSASLTLDRARQSLAREMERRRVASHTSSNRAGARLEGLDAIPASATSQSILQSIMGLFGLGTAPPPFEQEVAGVGLPSDEAEVLNISAFNFEGEFAWEKLDVQIEWAMASVKEDKATPGVGSTSGLETLLEWIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MGJ5</accession>
    <name>A0A2X0MGJ5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C034g11311 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C034g11311</name>
        <name evidence="3" type="ORF">BQ5605_C034G11311</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000065">
        <property type="protein sequence ID" value="SGY99881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MGJ5"/>
    <dbReference type="STRING" id="796604.A0A2X0MGJ5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070880">
        <property type="term" value="P:fungal-type cell wall beta-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051873">
        <property type="entry name" value="KNR4/SMI1_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47432">
        <property type="entry name" value="CELL WALL ASSEMBLY REGULATOR SMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47432:SF1">
        <property type="entry name" value="CELL WALL ASSEMBLY REGULATOR SMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09346">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Knr4/Smi1-like" evidence="2">
        <location>
            <begin position="152"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="657"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="657"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY99881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="706" mass="76074" checksum="F811EBC2546E9F82" modified="2018-09-12" version="1">MFSFLWNGSKKGASTSSTLPSHRSSSSRPDPASIWSADADYDDVAFGDTSEPGSEPYDGVTPVLRGPSILGSRDHFVEGRPVSNDPQASYPPLPSFSQPSSTKSRDPPLRRTFRHLEDLLADRSPALLDSLADPIVAATDPQLVSLLQLIAPYRLPPAVIEAYTLHDGQDPFALGGMSDGLIWGLRWMPLEEVEREWKAWRQLEAAGGLSHADSFGTFKDDPSNVSQGRGREHPYVEENPDAKPFSGREEGRADAGMSSFPNGWVRSRYSHPGWLPLLTDRCGNYIGVDLDPPPPPPRSSTASTSRVPGLAARGYGQPGQVIAFGREIDQKVVLFPGDGSGGWARFLAAFVEDVERGEFAVLDHPSGRGNSNTKANGWRKPNSDVEQGSGDQSPRSDDGWDEGDGIGDRGYLEGHSYGEEAEDSGGVGSEARNWVLRSEYRRLIAIVPGGLIGLIAERSRRKWRSLGVGSRNTSSTDAQSTKGKPPLAIIVPDTTEAGPESSTTVRASSPTTNGKNALSPPPVEVVLSPPSPIKSVSFNDEGENASLPDEPGSSTSSSTIPFKSARAQSKSPDHLNDGRSQRSSPSSSRSSRRMTPNRKNRPPPPPPAALDLPTRFDLLSVEDREPVQDSVSIAMDIGASPTTADFHAEEHEIEHVYTDLHGPDDPRDSTSSLRPEHSRSNSREEAVLRGLAVDSQVDLHEGDVMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MGM6</accession>
    <name>A0A2X0MGM6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="6">2.3.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C008g05230</name>
        <name evidence="10" type="ORF">BQ5605_C008G05230</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + acetyl-CoA = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:17017"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="2.3.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="6">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.12" evidence="6"/>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MGM6"/>
    <dbReference type="STRING" id="796604.A0A2X0MGM6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000003">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006257">
        <property type="entry name" value="LAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01349">
        <property type="entry name" value="PDHac_trf_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF90">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 6" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="8">
        <location>
            <begin position="33"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="9">
        <location>
            <begin position="180"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="126"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="222"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="137"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY79820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="487" mass="51223" checksum="E2BF4860DB21C577" modified="2018-09-12" version="1">MIRQLVQQRARSLARSSLSSPRYLHATSRSHALTKFMFPAMSPTMTEGGIASWKKKEGEAFAPGDVLLEIETDKATMDVEAQDEGVLGKIIVGDGAKGVKVGSIVAILAEEGDDVSEAAIKALTEDGAGEAAPAEVAEDKPQEKASETPEPKKQETKSETPSAPKKESSMQPSGDHPVILASPLAKRLALEQGIPLAKIKGSGPGGRIVKADIESYKPEAPKAAAASSSSSAPAPSTSSSAAPAKFTDTPVSNMRRTIASRLTDSKSGTPHYYLTTEISMDRVAKLRDVFNSAAKSAEAAGGVNDGVKTGTKLSFNDFVVKASALALNDVPEVNSGWHGDFVRQYHTADISVAVATPNGLITPIIPDVGAKGLATVSTLTKQLAGKARDGKLKPEEYQGGSFTISNLGMFGVESFTAIINPPQSCILAVGATEKKLVLDPESEKGFKEVSVMKVTLSCDHRVVDGAIGARWLKSFKAYLESPLSFML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MGT4</accession>
    <name>A0A2X0MGT4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C008g05280 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C008g05280</name>
        <name evidence="3" type="ORF">BQ5605_C008G05280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY80003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MGT4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037737">
        <property type="entry name" value="Srf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36819">
        <property type="entry name" value="REGULATOR OF PHOSPHOLIPASE D SRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36819:SF1">
        <property type="entry name" value="REGULATOR OF PHOSPHOLIPASE D SRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="507"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY80003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="536" mass="57857" checksum="7BB6AD91F41A43D8" modified="2018-09-12" version="1">MSSASSTTTSDHGESTGSPRKSYQMSNKRVVTTPSWARNIPKEEVEYLYDYNAPPPPSLGQSGANRQRSLSSIVRAPAPASDEGSNAQASARGSGDAKHNATAAATSSSSFTPSYLNFNSRAGATASTSNDKSSTPQGATNAHDDDALPNHTWPRSSSSTAHSASSAAPLNPRRKDTEEDTMNKTDADAVAGLAKATHNASSNLTASNGAAAVSAPPTGDRWWTFTLPSRYLDRVHDYVNRLEGDQRGDTLLPTTAVPTHNKEKRHSGDSSAEAEKHENHDLDPPRPSYARQMSMNMAARLAPSNVFSVNHTQTPGWSTPWAPFSRDEDSVNANRDPFSLVQAAQASQSKTTKFENFILNNVFAPLVFRAMNLVLAGCTLGIASHIRLQETRNNVIGIIGTSTLFVIIVGPFAIVHVFATVYIEYFGPPIGIWNVRTKMAYTLLELVFICLWSALLSLAFDDLFTSSLECTSFTPYARYNESPSSIGLSSVNGTVADSICQQQMAQVVLIFLSVMLCLAVLIVSLLRIFVRVSRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MGW2</accession>
    <name>A0A2X0MGW2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C008g05310 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C008g05310</name>
        <name evidence="6" type="ORF">BQ5605_C008G05310</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY80142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MGW2"/>
    <dbReference type="STRING" id="796604.A0A2X0MGW2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429">
        <property type="entry name" value="PROTEIN TWIN LOV 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429:SF2">
        <property type="entry name" value="PROTEIN TWIN LOV 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0157">Chromophore</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="424"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="90"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="563"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="631"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY80142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="826" mass="88359" checksum="52BD1B0399F96DA4" modified="2018-09-12" version="1">MSSWAPLPAPAGPLPEVPTTPRSFHSAHSTFLSDRRGFFDVNLRIESRRYDAPSSSAPAAGNRGPAKPSGLDPSAYSSMPALTLRIRSSSRDALQNDPSSPKANDVMDPSLRVNGSSRAAAPSSGPALIVGGASANAKLTEGDSSGDEDHALHDGAHGTCTVTDLNSPSTAPTSFDSFDKESVLATLAERTFRDEYSPVADVQPGLAPTVGIGAPAYAHSIVSVSSSIRFSHLPERPLNPSDPWKGRSSHPFPPAALSPLQASLAFSLARLLSRNTFDAFLATPAGFAQFHNYLSRTGGPTAAVHALELWKDLDTLKSTTSRSAMAAKAIQEVHFALENATIAPFAPSFARDTGEQLTALSVVGLGLEKPSRHLLNTLYANEFHGFIRHRLLQHTRAQLSKYELTNDERSGLGDVFCLTNPRLPDAPIVLASPAFCALTGYAAHQIIGRNCRFLQGQATAPESVQAIRTAIDKEEPITQLLLNYTASGAPFWNLLCILPLRDAAGELMYFIGGQTNLTGAIAAGSGEDLSFVLSSDDTEGGPVIDPGSYTDAVESNIFHEQGGIEPSALSPKESMAPKSPSTTIPTFKPSPRRRYSTVEPAALSTMMSCEDMMSGSAQPAVTKRPSFLSLFSRSKGTEGSGSSKSKKEQRQVPAPLILAPIQSRTSTVSPPSRPIPRKRAASVKDVRVKQPGIDPSIEHGAAPIEKKLLDFQMTYERVVILRADNRKILFVTSGFLRYLGLPGASLQDVDTSKLVHLDLLNLVKPTVHEPDQKRIRQRIKTTIEEGVSGSLRCALSFRGPKVEGTLHLSPLKNMQGDVISFVGVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-11-27" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MH91</accession>
    <name>A0A2X0MH91_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C032g11025 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C032g11025</name>
        <name evidence="3" type="ORF">BQ5605_C032G11025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000067">
        <property type="protein sequence ID" value="SGZ03850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MH91"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="2">
        <location>
            <begin position="336"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="GAG-pre-integrase" evidence="1">
        <location>
            <begin position="443"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ03850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="576" mass="62154" checksum="D71F879F766C40A6" modified="2018-09-12" version="1">METSSPLTTGAHPTIPTEQLAALTSLLSGLTTATSATSSGTSRTAFPKHARLDGPKMFASWTRQLRKCLADDIRSYVLDGIVPADWTPSHRSARDVVARELLAHSIDSADVSAVLDQIPTADLTAPKIYSTLKSRYAPDDATRTLELFSRLWSFRPMPGTVGEFDGWIMEFKAIAQEIIDTKTTINDVLATLLLAIAHPSLESFKASFTDEQRTQRSLPAIDSLANRMRVQLRSTNVPSTQSALLASSSSRPTRPKCLACRSPSHRVAECPVRAKHPPPGPCRSCKQNHWSFDCKKALENGKKADTANSTADSQHHVGCIATGLLARRRQLRTNSFVVDSGATSHMVSDKSLFTTYRHIAPTKIGGIAGGINAIGTGNIAFVAASGHPITLTGVLHTPGLFVNLLSVSRLCDTDDVRVAFTKHGIDIDKDGNNIAEGTRLDEGLYLLDADHSKCQHLALLSRSQSSVPLLTLHRCLGHLAPSSIQKMVAAGLLEGLGAGYSDEEVEKFVCNACLSAKGHRLPFPDSDSHSSERLGLVHSDVLSLPERSFVKSPLSARQRRLGRRAHPLARPLAVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHL3</accession>
    <name>A0A2X0MHL3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C032g11112 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C032g11112</name>
        <name evidence="6" type="ORF">BQ5605_C032G11112</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000067">
        <property type="protein sequence ID" value="SGZ05165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MHL3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008263">
        <property type="term" value="F:pyrimidine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10028">
        <property type="entry name" value="UDG-F2_TDG_MUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015637">
        <property type="entry name" value="MUG/TDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12159">
        <property type="entry name" value="G/T AND G/U MISMATCH-SPECIFIC DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12159:SF9">
        <property type="entry name" value="G_T MISMATCH-SPECIFIC THYMINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="5">
        <location>
            <begin position="989"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="333"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGZ05165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1302" mass="144566" checksum="8B028A50601D7F13" modified="2018-09-12" version="1">MAVDVVQFAWESLEGELFIHLSLIIGKCAKGRLPDPLVLFLQRSDIVKVGVGVAGDLTRIANAIAHAEMWNVDEADEDPVAVAPTLRHHGGLELVEHAASQGHSVKKGPGHRTLLGLCERFLLKYLPKDNNIRRSMQWADESLPQHFVDYAALDAYASLRLYHKISEPHSRPLSKIANPRVGTRVAVMYESGWPIVRGVIQSIDSSIDSSCQPPSSFHGFKWDKSRAIVAITQILTPGALVPEYNFHQDGSFTPQSLADLKATSTHRAAEDTIAVQESADSFSLVLELSALVVDLDDAPVPTEAQWTSNVSATHDSHHASEIFIQEKHSDAAVSATANESNRTDDVDAQTDDHDKDSELVGPAEIAQALQLDRSKKTEAAGKAIWGKAATSKVPSSDETAVRILIDLWHFFDRIYVSKKHGAAKAFARAFSDAVFIPNADDRLLMEARLAKLGMTWEEAVRSPVWNKKLWRRVRRWIPPPSIFEPLVREVFEKFGPLIDAKSKQPLFNKAAHEAAKRCLEAIRKGQVSDPVGIELYTDLGPCGGPDGKADDGVRLYSCQRGTNSLEGGIHRNLRQRFPKSGVSPCHANACLADYVVVHNLTVSPTPPSRFEEAATFLTHYPLYSQVGTFNRTGKPFVGHYDLWLTVELHCLRRKTSAFLPRHSTTVSDIVNPLLYNPSTETFGIIPVQPPTAQVRFLIEPYHVKRGTLRLEPVKWSPRNLLQNNTPAIQHMQSRLPTDRKLRHDWLVERQGTRFAVLHVHTPSERALYRYLSSKIRLGAPQNLRILEITELWNKYANGVDIFYNMPEHINTWASRWSSLANAQATMNMGGNDVRVIQALLTDPSRGRDVSMLVAKPLLGHKPPALGRLTEIEVDAPDPPTSSIRPFVATASSDAGSSADLGTSSALTRAGTTKGARHCRFCGQTTCRLKGSKLSDDGSVTGCEGACLDCGKPFGLTDEMDPNDSQSQRFCRGLTRAEMNSRAWHQKKYLVICGINPGCQSARTGHHCAYAKLMAACSSTRSSPDSFHLPPPDAHPSNHFYTCLHQSGLTPRRFDPSACRKLIKKCSIGLTNLVERPTRQETELKKDEKRAGCANLLAKIEKNRPHFVAFAGLDVGRVFRDYLVAHEGAKRTYDSDEADYFVPKSRTPVKRYQSPRPKVESPLGLKKEDTHVGVHTKTKEEDKEGRQLMTSGVDTKIKTEPKALPKGWARDLGLQPVILSFPPYGKHAQGSKRRTKTYLWLFPSPSGLVRLYQLPDKTDMHVRLRETIQAVKRGEDPFADFRRAGGEVHEYLAEMIMGGEELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHX3</accession>
    <name>A0A2X0MHX3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C031g10985 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C031g10985</name>
        <name evidence="4" type="ORF">BQ5605_C031G10985</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000068">
        <property type="protein sequence ID" value="SGZ06990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHX3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="192"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="404"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ06990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1075" mass="118779" checksum="AB00CC4941865307" modified="2018-09-12" version="1">MDNLPPLFDSWRTTFYALQADKNKLPRAEDIFASMEAVARISRNESTPALVAKADVQTKSAAPGRKGKWDQSGLAPSNCPACGQGKHWADKCPDLVKCTKYFELKNAMKELKGASLAPAPALAATKSSWLPLLTLHRRYGHASVQTLKKLAASGQVKGLDWTYSDSECAEFTCNACLASKAHRSPFPSLLSHAAEPLALVHSDVLSFPEESINHFRYLVTFVDDYSRKTWVYPISHKSDVLPTFKDWLLEIENATGRRLKTLQSDNGDEYISSTFNGYCAARGIRRKLTIPYTPEQNGRAERLNRSIVKGTLALLHTKNLSSHAALKGGVPNHRRSGTAPLGIPLVFVGYDCHAKVYWLLNPTSMRVSLSRNVKFVETEFPFLSMPKRATAPSIRGYCPIAQPMLQPEGPRATPNQLLPPNDELPPPNDELPAPNHEAASVRSDATDAAEVLPPPEQVPEPPAKVKPTWEYGDLARVGPDPGKYGEVDPRNIIEGPRTHCRLVLTMIAKEQLDSGPDGPTDAFKNLILAFAATTEGFAEHDLAMVRDPANWGDVIRTGQEEVWHPPARDEFNLLLNDYEVFEIIESCDLPSGEILLQSGWVFRTKRNQHGDITDHKARLVAHGCSQRPGLDFEKNYAPVVKFTSICALIALAAANDYHVHQADVNKAYLHGKLDKPLYMRSIYGLRQAGTIWNAEIDSTLRSLGYIPTKSNICIYRRDHDGHLHYIALYVDDLLLVGPSVAEIDRVLDALELMYGIKRLGPAEYILGIQVKCGQDGSITLSQERYLRDLLDKFRLGNAKPASIPMQPGVVLDFQDSSATPQDCTHYLQAIGSLMYAAVGTRPDLAYVVAYLAHFSQQPSPAHWTAITQVLRYIKGTLDLGLTYRKTDVAFHGYSDANWGACLTTLRSTMGYAFIYSGAAIAWCSKHEHRVAKSTTDAEYLSLSYTSGDAIHLSKLLAELGHPVPGPVVIYGDNQGALALAQHPTNHQGSRHVRISEHYVRERVAEKEIDVVYIATADMFANIFTKALGPKLFLFHRENLGLRGAVGSKILMNLRDIAVCGLRSWSCIRPALSSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHZ0</accession>
    <name>A0A2X0MHZ0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C009g05502 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C009g05502</name>
        <name evidence="4" type="ORF">BQ5605_C009G05502</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY81497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHZ0"/>
    <dbReference type="STRING" id="796604.A0A2X0MHZ0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="186"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY81497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="410" mass="44947" checksum="395B611FF7AFEC4A" modified="2018-09-12" version="1">MASPAPPDKLPAFDNSIGAFVSPGFVPKLPFRTKAASRSHPSSLYSTTQCFTYHLRFHRTDRLVYKVVVYGLFVLDTMHSAFCCMTIYWWAVTHYTDPAVLSISPWTFTVDPAVTATATIICQAFFAYRIYVISGRSFFVPVLIMTLSVLQFGFGVASSFMIHFLDSKFSRFHEFTYGVETWLVSAACADILITIFLVYYLRRASSTIEYSKTHTVIARIIRRTIETNALTMLVAVTDAILFSTGPGLAWHVIPNFLLVKLYFNSLLVSLVNRPSLTTPNGSDQFLGHGTDGEAGVGDTRWSGYTTSLKGGSPIISTGGSSFATAVHHRPQITVQTQSVIECEKAHPYTHAANAVSGGAMLESSPIEEEERFEALQPGSNPASPTTANANTDTNSNGRTGSRIPLSWASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIX8</accession>
    <name>A0A2X0MIX8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Adenylyl-sulfate kinase</fullName>
            <ecNumber evidence="4 11">2.7.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C028g10575</name>
        <name evidence="14" type="ORF">BQ5605_C028G10575</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the synthesis of activated sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the APS kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.25" evidence="4 11"/>
    <dbReference type="EMBL" id="FQNC01000080">
        <property type="protein sequence ID" value="SGZ13542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIX8"/>
    <dbReference type="STRING" id="796604.A0A2X0MIX8"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000212">
        <property type="entry name" value="Adenylyl-sulfate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059117">
        <property type="entry name" value="APS_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003013">
        <property type="entry name" value="PRK03846.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055">
        <property type="entry name" value="BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055:SF1">
        <property type="entry name" value="PAPS SYNTHETASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01583">
        <property type="entry name" value="APS_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APS kinase" evidence="13">
        <location>
            <begin position="60"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGZ13542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="248" mass="27583" checksum="79EDE69A3B7CEAE5" modified="2018-09-12" version="1">MERRPGEGAQSHQPTRTAPHPTWLTVVPGFGRSSSVPVSKNIVWHEGVTQEQREQLVSQKGVTIWFTGLSGSGKSTLACALELELLQRQKRAFRLDGDNVRFGLNKDLGFSPKDREENIRRVGEVSVLLRNFSTPLGVAKLIASSCTATLTAFISPYLADRQLARTIHDEAKIPFIEVYVDAPLEEVEKRDPKGLYKKARAGIIKEFTGISAPYEAPEKAELHIKTAESDIEAGVKQIVEYLEKNNFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJ18</accession>
    <name>A0A2X0MJ18_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C029g10613 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C029g10613</name>
        <name evidence="8" type="ORF">BQ5605_C029G10613</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ14717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJ18"/>
    <dbReference type="STRING" id="796604.A0A2X0MJ18"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF22">
        <property type="entry name" value="GLYCOSIDASE CRH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016171058" evidence="6">
        <location>
            <begin position="25"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="7">
        <location>
            <begin position="94"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="534"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="544"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGZ14717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="608" mass="65106" checksum="115377BFCDCD8FD4" modified="2018-09-12" version="1">MSGSISHAALTACVASLLVGHAIGQNAPSGASGATTTTGAAGSTCSWQQKCPTTAPCCSDSGVGCLNGCNVNTTGIGYPNLAHESSMERGGLLRPYPCLPIHKCESYTFADTSRIALNSSAYTGDAAKYDFTLDKQDGTTSLIQDGELALTLTEAGGGTRLSTTRAVLYGNIQASIKTVGAPGIVTAFITMSGSKDEIDWEWTGTDRNEAQSNYFWEGDLNDYKNGGTAETSSNRANNYIVYGFNWTPDQLQWTVAGKVVRTLTRSSTYDSASGRYEYPQTPSRIQMSVWPAGIVASAPGTVTWAGGMIDWSKAPFQARIQWISLQCYSGLNLSYEAGNTTSSFNSSSRLAKREIGEKSSLWKRGGLVERADSINSYVWGVNNSAGQIQVTVSNAATIINSVYSTGKNMIVKGSDTKGVIPTNESGNALSNSALGSWWYKLPTAAKAGIIAGIVLATLFLIVALCTCVARRKDSRKAKAYKPVGDAISLNKTSAAPVNSRTQASTASLASTMTKNNTSAYDQSNYAHPQAQRYDLAPPAPEWPTAQNDYDQQQGHSSPSYYSYPEQTASHGNYYDGSHTPQASQWPHKQHQQQHHQPPQQYYSTGAKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MK27</accession>
    <name>A0A2X0MK27_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C032g11091 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C032g11091</name>
        <name evidence="1" type="ORF">BQ5605_C032G11091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000067">
        <property type="protein sequence ID" value="SGZ04815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MK27"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ04815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="80" mass="8940" checksum="BFA9C1289265CC42" modified="2018-09-12" version="1">MRLWLGFRGSSQSSLSDLHCVVDVSLPASMAAFTTCRDRCVPHSQDYLPADEVADREFHLAGRSQLLAARYETLDVARLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKB6</accession>
    <name>A0A2X0MKB6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C033g11134 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C033g11134</name>
        <name evidence="2" type="ORF">BQ5605_C033G11134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000066">
        <property type="protein sequence ID" value="SGZ01250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MKB6"/>
    <dbReference type="STRING" id="796604.A0A2X0MKB6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ01250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="309" mass="33907" checksum="94E9BF62FEBFB844" modified="2018-09-12" version="1">MLFACSRRYDSTTRQDRRRQADLFARPSTQHDGVHNHRPKLFNGNWTQLNHVLDLIIQLAREDGPTHEAESIIGSPTRWMKRTKSAFVSSHDMAPEGLASDQIDASLDATVESNSFISGRIRNLLSHCGDPPPVEESNCDKLSSDSTDVDMEDAQEDSSGSDAERGCFSLPRSNMYHLCLCRSIMGQIAFACNRRNNAMQHRNGLMALACGANNRLTTPARASICTDRGTKSSPNRKGDSLNSIDGDRRGVPLTGVGVCTGMVDHEGGSDVVDWRCGPKVRPVRPGWLIHVGAKNRPSGSVREPAPSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKR8</accession>
    <name>A0A2X0MKR8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C032g11059 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C032g11059</name>
        <name evidence="2" type="ORF">BQ5605_C032G11059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000067">
        <property type="protein sequence ID" value="SGZ04372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MKR8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035361">
        <property type="term" value="C:Cul8-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019021">
        <property type="entry name" value="Mms22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28122">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SUBSTRATE RECEPTOR MMS22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28122:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SUBSTRATE RECEPTOR MMS22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09462">
        <property type="entry name" value="Mus7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="622"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="845"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="278"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="572"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="677"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="726"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="761"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="772"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="862"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ04372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1869" mass="206989" checksum="8B2B2817960639F2" modified="2018-09-12" version="1">MNILGLEEDGWSPQSPTPSPVSARCTASERDETRRPLIMTCTLQPMTTPTERSSSVAPSDLGEREERSVRLEQEDYWERIEELARMTALADHLELQQPVQTPRSAMIPHGQAETSTVHPPAPGPSTSAHSTTSVRPPAANRIGTASPRRRIATPPVEFPSISSSFQQNSPLPSPTREFDRPLPGPGPRLGSPNNVPSSIHSSQISVASRTLSQILASPSGTHQSQVIVPSPSPSPSPSPSDCSENRHSPRARSNSAHAVRPSRSPTPNRPRPHLPALSPSSKSSSPSSSAPDSTAQIRPPEPEPAGRGLRQRTLAQLNPYSIEQAHYTRTLLKNGWQGAVVSGVRKGDEMTKEEMMRRKEELRKKGKDDLGGWLDFEEGEMVRRDEDESGRMETEQTSGSEDGEALLEREARRRKRMQREVTRAMGPRGVGILESSVPIRRPNDGNDHRGTPVQRANQDQAHPTAKRIPGELSKGMNQSRIRMNEGEEHTPDESMEQDDTDLSASSSAPVVGESSKKRKRALPSKSLHARSKRSALDKSALDCRILEVEMSASSDSSDQEEDSDEEEDEDQSMNSASSSSPRRPPLVSPKDKTKLQGKRKKALRMMMPAVFMKKAQKDLVAMEREKREGLTSASDFGSGDDERLSSSDHAPAKGVARIRRIPGLDLAGPLRLKGDAFTDESGEDEDMMGRGSEEEAEEDAVESWLHAFAPRRRVNDDEDIVDRFLKRAKRNTVGTKRKNIKAGNPTGSKTNEKSKTHRRPPLHDKGNRPSHDQTGLTANKANTRPSDQHSPSNRRSSRPMKKAVSLDTGDAIFSFARQASRHLVLDEEPEQSDIEKMIPRLAPRNMGGVPAVVTRDAPRPPSMTATKTTTAAAPSRAPADENEHWATFGKFSHDFEIELLPVGLQLDDSSFVRRGHLESLLRRHTPDESAHNTHLTLGELALDGAMTPEAVEAMLPQFCDGVFEVICQGDEAEMMTCSGALHLLGRVISSGSVISTSLSASISSQLDRLEERLDSVSDVAKDVKAFSGRRLVLLWYGFDLAIRLAQPAELVHSLASKLIDRLVHRGVESTMKGLKSASSSPETALNDISLHVWLGLVSVAVRDFDGIPWRQADLWMITLERIAAQLSPRAQKGPIAGEIMSYTTMMLCAISQFSYLGISTSTPRLSAHWGVIKRALEPINVVALARPDHALSNTAIARRDRYVWTLFARCLVFVNRWNWKIDQRSDVLPKLYDILNARRLADLSIETHGDFAIFLQHPDQFNSTKALVLHPKDDTALSIMLKLITNASRAAVASGEFRQLTRLFSRLTPMTSQAWTRASPELLRSHSTLVNHYSLLITFARLVAAAQPASNLALQYLDQARRIIDFAQVDEEARRINVRAVLYFMLAFQAHDLDLAPAAMWFGSITTQLKKEYIDIEKQRRIDIRGLGRKAGNLPRPTGNDPLWHRAVLLTMVLRSIQLVLRSTVKDENTFPELCLLGSAWTSLLLESPLALDPMIGLEIVRTVACFLDLRARAKPRINATTPLAATDADAGISQDEFGMFDDMDFEDPALNAMLGVESTTAPEGGDDRDLFKRKDAGFAQMIKSELSPAFFRLVSNIFGSTEWRGPTVGDRVAYAQQVVETWIRCVAIMVQHDLVDWSGYLRYGDQSWKRVLDPIGRRTIGLLLAILILRHEPDAYSLFQDDILEIWFQTIVAYSLSSEHILTSRLLNAEPVSPLFEDAQILLERNEDCRFELDEHTIDERRLDILRSVFKSAARHLVASNANPPLFAGSKSSLNRAMILNLFRAMLASMKDHLAVGSLFSFPLRSACVPDLYSPISQAITNERSRDSYATFVRHVLDALRGCGAPDVNEQSLVDWRGLEKCVAGASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0ML46</accession>
    <name>A0A2X0ML46_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BQ5605_C002g01585 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C002g01585</name>
        <name evidence="12" type="ORF">BQ5605_C002G01585</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Mitochondrial peptide exporter (TC 3.A.1.212) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY34064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0ML46"/>
    <dbReference type="STRING" id="796604.A0A2X0ML46"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18573">
        <property type="entry name" value="ABC_6TM_ABCB10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000218">
        <property type="entry name" value="Multidrug ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="328"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="163"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="529"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY34064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="788" mass="83805" checksum="C2086BCFFE70E25A" modified="2018-09-12" version="1">MSRPSAVSAWRCVASRFSTTTCSAKTIPFTSVSTHSRAVDRFQFPSRSYGTCSASDARSGRAGSSSLIVGVGSRRPTMTTLSSIDVPSRSLTCSLAQRIRYASTTPGLATSSTATATSNKDKDSLEEEEASASDLAKKPAEKIKIGEIRRLMILARPERKTIAIAIGLLFVSSSVSLSIPFTIGRIIDLFSGTAPQGLPISVPTAAALMALFFAIGASANMGRTILMRISGQRIVARLREAAYTNVLKQDIGWHDLQGAAKIQTAELAVPAEAPSSKFSAEVTTAKPPKVVEHQVPQTGVRSTGDIISRLGSDCGIVGESLTRELSEGLRALVTATVGIGAMLWISAKLTAVMMLIVPPISIAAVFYGRYLKKLSRRTQQAVGEMVAVSEERLASIRTVQAFNAVEPLETQRFSEKVDKIFGLAKKEAFASGLFYGGAGFAGNLSLIALLTYGGTLVAKGALTTGQLTSLMVYTFYIGSSLFGLTSFFGTIMKGLGASSRIFELLDARPISVTLGVGKPLPVTTPPRRIIFDDVHFAYPSRPQAEILKGVNLTIEPGQIVSIAGGSGSGKSTLANLLVRYYDPSQGRVVYGEDNIRDFTVESWRQRIAIVPQDPALFSTTIAENIAYGRPNASRAEIKEAAKLANCGFIEALPRGFDTLVGARGAQLSGGQRQRLAIARALLQKPKILVCDEATSALDAASESLVNMAISNISSSHSLTTILIAHRLSTLKTADRVVLMDNGVVVEQGTYEELTRSGTRFSQLVASQMLQGSVTGLPASSKIEARQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLF1</accession>
    <name>A0A2X0MLF1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C002g01685 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C002g01685</name>
        <name evidence="3" type="ORF">BQ5605_C002G01685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY34801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MLF1"/>
    <dbReference type="STRING" id="796604.A0A2X0MLF1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN" evidence="2">
        <location>
            <begin position="92"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY34801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="391" mass="41934" checksum="D3A1E5C1CB9F5826" modified="2018-09-12" version="1">MSANDPSAQDKRDRLSKALGAAFLSHQVESLERSVDSLTFSCDGRLLPPPRPTSTGRTVQVNSTSNHRNGPIMKGGSDTRSGTSGVKRPIKVVDASVLVHALPVVKRWLRQDTHQLVIPLQAFSTLDALKKAPAALYDLAHEATRFLESQLAIAQRIEMVLGGPGPEADAKIRLRAQAAGEEVSWEQVEQFFQIPPKAYPLVNQDPPVDSENEGPTDVIEPRLPSAQDLPCSWRSPLQCALFFASQSPKHLFVLFNTLHLLDVVAPPPPAIPFISGSAKRAPPPSLNYLAISSGDTLARFVQTHYERSIPLYVVPSSEVVAAKEWLKALAKETATAKGNLSQGAKPDSKGSKSMGSAHAKRRSGTTGDRGGAGSKGGRRNGAGTEGKLFVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLH4</accession>
    <name>A0A2X0MLH4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C030g10826 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C030g10826</name>
        <name evidence="10" type="ORF">BQ5605_C030G10826</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000069">
        <property type="protein sequence ID" value="SGZ08932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MLH4"/>
    <dbReference type="STRING" id="796604.A0A2X0MLH4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024882">
        <property type="entry name" value="NUP58/p45/49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437">
        <property type="entry name" value="NUCLEOPORIN P58/P45 NUCLEOPORIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437:SF2">
        <property type="entry name" value="NUCLEOPORIN P58_P45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15967">
        <property type="entry name" value="Nucleoporin_FG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="27"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="27"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGZ08932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="283" mass="31630" checksum="414F4B7D121BFB3D" modified="2018-09-12" version="1">MMGGLFGTNTSTGLGGQQRLGLFGSTIQPQQQQQQQQQGGFQLATSTQQQQASTSSLNKMTKFNDLPENVRAVIEGIDSFVRQQVHLSEQLKRRELGVEIEKTRNEWQQCSADATAISSLLLHSSNSVSAVRNRLDQDAQDVEKATWIVEGFKNPQGPKAQQAKAVQTFPFEFFRNKTDEFEARLKNYKETIEQIQQYLSSPSSLSSSIDPLSIVPTLKSQTTSFLALASNVASLQSDLDRLKDEYRVIWRDRTGRVMDPFREREGGRDVAGVVSGLGRVEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MN60</accession>
    <name>A0A2X0MN60_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g02217 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g02217</name>
        <name evidence="2" type="ORF">BQ5605_C003G02217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MN60"/>
    <dbReference type="STRING" id="796604.A0A2X0MN60"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY39429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="120" mass="12820" checksum="E37CF56A74BB8EC5" modified="2018-09-12" version="1">MDRGNSSSSSVGGQQSGPLMAIASQPRSDHGSRPSSAAVSDDEGERPRRNDDAHRALSDSDEGAEDGGHRTRERVARASRDGGALTFVDAPVAPESPVKPATTKRARPSRKATRDRRRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNH7</accession>
    <name>A0A2X0MNH7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C014g07509 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C014g07509</name>
        <name evidence="1" type="ORF">BQ5605_C014G07509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY18932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MNH7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY18932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="362" mass="40003" checksum="F6130A7CC68250F8" modified="2018-09-12" version="1">MCLIPQHAVATEDLIAVFEQRGDLFRDLWRAFEDSIIISIDLGHPRPVTAVARVFTHDETAAFETFRFGKEGLGAIAAEGNRKGARQRANKTHRINEALRANKLEWSPLAAKLGFPLRHTHDAISVSSTQQEANLTIMYQQAEQMAKVFGLECMGESALVKFFLAIQENRLGCSSWVESADTYAIRHLAAAARRPNHLVPSPPTHPETTTYNHLLSKSSRPAFLIVGNGFTSPGPNPSGVSYAQSCIKIIFRCLQALGLESMYFCTVSEYLTSKLCWHSDCRDTDETRNWVGLGQKSNGCRPYRISCSNAFRQFPAPMMSRSAGMWTQVPPPRATRKQVDPVGSRRCASIAGPAVKSSMGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNJ0</accession>
    <name>A0A2X0MNJ0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C014g07519 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C014g07519</name>
        <name evidence="10" type="ORF">BQ5605_C014G07519</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY18962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MNJ0"/>
    <dbReference type="STRING" id="796604.A0A2X0MNJ0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015007">
        <property type="entry name" value="NUP2/50/61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08911">
        <property type="entry name" value="NUP50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RanBD1" evidence="9">
        <location>
            <begin position="698"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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        <source>
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    <sequence length="825" mass="82633" checksum="28BC77844694CADD" modified="2018-09-12" version="1">MAKRGADKQLTDQNWERDASDDEDNNSKGSGEASFKTAAPEALAGRRIRGLPQRKGAGGPTPAAATSTSSAAAPTPSPFGSFSGFGAAPGIPTSNPFAGFGSTPTAPSTEETPAKPNPFAATTFSFGSTAPSSDTTANKPAPSAAPSTGFSLGGSSFGASSTTTPSTTAALFGSASTSAFTFGSTPKQPEPTKPSTNGGSDTTTPALTYYLGLRGLNISLLEALTKEIDADPFMNLAGQGFDAMKQKYESLRTKIEADYIKAGGKADANGFSAASTSSTSSSTPAFSFSSSSSSTPAFSFSTAPSDPAPASSPAAAPSFSSFTSPPVPAAVASTPKIAEETSKSTAPAVSALAPPAPPATFSWGGDVVKPTPATSSPSAPVTGGFIFKPDAAKNGDVEKSGFSFPSGTAPPAAAPSVTSSATTASSSSLTVASKPSQYGSVAKRVSQLANAPTAPSPLRFGESVSPPLSPVRDEAQDLNEAEKKTADAEVPKKDYSTVAPPAPFSFGGSFGAIAKSGTEVAKDKPATSTSAVSFGSSSTAPASITATTAPLSSAPPPAFSFNTPIKFGSSASVLSKPTASPPLATTFGAGSPPSFGFGAALGKPLSASTSTSSAGFNFGAGSTPGFSFGAGAPAFGATSTTGSSSSTPAFSFGSTAASSAAPSATASFSFGASVTNTPVPPASTEAFTDDSIPTSEHDDGLETKDLGPAEGEEDEMTLAEARGRAYEIGKAGENNLLAVVNLFVKERKDEAGKVVKRLLARNETSKAVVLNFRLHSGFTVKLEKMFLTFQGFSGSDPKIYRVRFKGVTEATAFKEALEEAAKGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNW5</accession>
    <name>A0A2X0MNW5_9BASI</name>
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        <submittedName>
            <fullName evidence="2">BQ5605_C014g07639 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C014g07639</name>
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        <name type="scientific">Microbotryum silenes-dioicae</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY19409.1"/>
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        <property type="entry name" value="KDZ"/>
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        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
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    </dbReference>
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    <sequence length="770" mass="86592" checksum="F610BAEE647E355D" modified="2018-09-12" version="1">MDILPHTPPPLQPRSASPVGTEKGKRTDKTKRKKSTTVRRRRRKKVTSSNKDTFENGATTSVGTEEEAKTKKMKRRKLWTKRVRKREPSLSPDSELFDKAFGFNFGIFRSPTKRRPKRQPGPPLSPSVQRSTHRRKEHSEKSIAGLHKSSSEPWTDIADCATAWPLDTETGGFEHNFKPNSAPDFEPDYDFGRDFGGGYSSGPEHSPFHPDGASQDQAPSSLKRSQIERNAKKQRNRRRNARAEAKTRASKRAELLQAYLLMKKKAKEVLRQSGFVPFPDDEGWCDACHERRVTRKVRVVDLFFAGMRELRYCPCYPEIQTLAAHGLLPTSSSSIRKRESITAFTFRTIEYLNTYWGVDPFGIYDMSEALILFWSSELSSEDPFNKGPTVRQHLQAAMDEYRFMQQLQATLTAEFIGLSPRERLADVCPACFGPRIDEAGKSENDLDVIIAVDGNFQHRRFARATADPLKSRPALFLSPDKIRNEQALIDGSTEAGEQVPWCCWCRDECTANWKAADGGVTSALSNVVADTGLVAAVCRHDHCLRLCNLHQSGENLVYRKLVYPVSLLKWILEEVEVGETDCTTGPARTSDATNVGSSSGSGSHQSSSQDRSRVGVAYDIACNLSSHLRRLISPRYAQRNLLADHLPRLEFALSSMHAYAHKWSCQVEFDPRFLPSTGLTDAEGAERLWSQLRGMIPMNRSSSASHRLENINRRASAYNKQHLAELGSPKLTKLNSRLKNAIKLKAEADRVIAEVVNRSAEWTVATLLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPH5</accession>
    <name>A0A2X0MPH5_9BASI</name>
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        <submittedName>
            <fullName evidence="5">BQ5605_C023g09680 protein</fullName>
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                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="La_dom_prot"/>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
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        <property type="entry name" value="LA-RELATED PROTEIN 1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1096" mass="110784" checksum="1FCC9B94DD927915" modified="2018-09-12" version="1">MSSTPTWAQRAQSLSSSDPTSSSSSATNGSSMDHPASSSSAAGGAAASAAMAPSSGSLLPLHVAPMASSSKASTSDNWRADSSLHNTHHDTLHSKDSTADPDSSAHNDDGWVTLEKKDRSSRKATHTPAMSSTSFSSKGGAYSKPRTSTKPLNNSAFSASSISGRTANGVGSHGRSSLSGPLAPSLAVAEATSAGPSSSLAVAPAGSSMAASDPSHSRPASLTVPTPALPASRPVLDWADDTDDSLPPLPSPTFPTTALPPTTTAPSTQASTPALSDSPDTPENASTVASTPIDEHTITSSKTSQPQSAGLASESASAPSPAPVVPAPVVRQPAPVPTVNVWAVRKDQLAAAAAAAKAAQPVAPNSASAPTASSSSAATTTVSGSAQNPTGTNPVPASKKSAAKLAKKEAAAKAAAAAAAVKSGPRAPTSSLTPPPPPSATLNSSPTPAPTAAQNSTSTPIIKRSTEGWNGVPSAPLPVPVGDVESWPSPNTEAAKPAGPVKKYGSAASASNEAEIEEAQNKKKAEKTKWIPIKADITVNPTSSSRLFGASGEKRVPKSGTSSRREFGGADKGAEENGVGGASKRAAGEKKPKSAQASVAAAAASTPAHAGSAKDANAASTSSSNPASTRPTDHPLPSKPNSSPSSHLPAQQAAPSTSSPSAQPATSAFATLTVAAASKSAPALKNGAQAATEGDSASSAPKSAPNATVSPTSATAPSANKASASQSSSSVSVAVPNAPTSQASKGQPTPNGNAQAPFQNGTSTHGRHLGSGTTVRGGLHASRGGPTARGGRSGSMSSRGGYQGSNPRGPASSSSLHQAQQAQAAAQQPHGAGYLDPTTAYWHAQAAYGTVALPDAVAPWAYEQAQPYVDPRVLDPTRYWLLGQLEWYFSVDNLCRDMYLRSKMDAAGWIEVTIIASFNRIKNLTSDRKIVRDTMILTPMLEVSGEFVRLRQHWPEWVLPSAIPARIAHSHHVPGLQMAAAVTASAFVPPSQASSLTNKKRREESEASSEDGGEGTAATTISSGSQAEDVAPAAKEETTASTTPSTSSIALMFHQDHHHPSKANLKTEIRRTSDRGLPTAGRAWTRVCRARSGSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPT3</accession>
    <name>A0A2X0MPT3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C024g09792 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C024g09792</name>
        <name evidence="1" type="ORF">BQ5605_C024G09792</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ25891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MPT3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ25891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="127" mass="13724" checksum="D894AF4ED8885E3C" modified="2018-09-12" version="1">MTPTFSVLSWTRSCSSNWPTLLTPEPTSAASRTSLVKTSTSCMLKSLRNVTMSSCTLTTIPVSSTFDPAMTLMWSPGVKRLRTLLAGTSTLASPRSRSACGAIVMTSFRTVSIVPYIPFWSPSMMST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPU4</accession>
    <name>A0A2X0MPU4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C024g09802 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C024g09802</name>
        <name evidence="3" type="ORF">BQ5605_C024G09802</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ25929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MPU4"/>
    <dbReference type="STRING" id="796604.A0A2X0MPU4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018849">
        <property type="entry name" value="Urb2/Npa2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10441">
        <property type="entry name" value="Urb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar 27S pre-rRNA processing Urb2/Npa2 C-terminal" evidence="2">
        <location>
            <begin position="51"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ25929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="178" mass="19953" checksum="99B2C8CBB7A436F7" modified="2018-09-12" version="1">MLTALRRSGYGTTTGSDELDPLIPTEHMTLGKRADRTTAATFPFWVWYGGLQTIGREHAKAIGRLLISLSTKTTTLTTTTSSLAMATKSKLTSSLVAPLSKHAPFLILIYLRASVHSTSPIPLTLRSELQGGWFEVMDAMGKWEREALMKGFLKDEDEAERAVLRRMWKAYEKERYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQQ9</accession>
    <name>A0A2X0MQQ9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C040g11850 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C040g11850</name>
        <name evidence="4" type="ORF">BQ5605_C040G11850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000118">
        <property type="protein sequence ID" value="SGZ32300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQQ9"/>
    <dbReference type="STRING" id="796604.A0A2X0MQQ9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004015">
        <property type="term" value="F:adenosylmethionine-8-amino-7-oxononanoate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004141">
        <property type="term" value="F:dethiobiotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03109">
        <property type="entry name" value="DTBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000080">
        <property type="entry name" value="Bifunctional dethiobiotin synthetase/adenosylmethionine-8-amino-7-oxononanoate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42684">
        <property type="entry name" value="ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42684:SF3">
        <property type="entry name" value="ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13500">
        <property type="entry name" value="AAA_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ32300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="810" mass="88293" checksum="905DE77B7C5F5073" modified="2018-09-12" version="1">MLYNHLRTHLIVAPSTSVGKSIFSTGLCRASLAQGERVGYLKPIGTGTGDGDDELHLKRFAPRLSSTKCLFHFDEPVSPHLAVARSGSSSSAASKYPTDDTFVRAISHHVHQFAQDPASAVRQAAGRGASLYIESAGGVHSPVLSGSSQIDAFRPLAPPSTLLISSHALGGISTTLSAYESLLIRGYRIDSVLVFKEDYYENYSYFQKWFEQERGIKVGIAPLPPSVAEPKERDEQNMDTYYATLEENLSPVIDHLRDTHQRRLDELASMGKRSRDVFWWPFVQHNQVARDQDVMVVDSAHGDHFVTLDHKVDAASSKALLSPTFDGSASWWTQALGHSNPTLALAAAQAAGRYGHVLFPSATNEPSLRLAENLVRGVGQGWAERVFYSDDGSTGMEVGLKMALRSYAVRRGLNAEDAGRLKVLGFKGSYHGDTIGVVDACEKSIFTERIDWYNGRGAWLDGSQVMLEQGKVVIRDRKTGQSIGTYNTLKEIYDVDQRLKDDDSLVERYRHEIAAFVREHHEAGTEFGALVLEPIVMGAGGMIFIDPLFQRVLIDLVRGDSTLFPSCASRNASTASSKTWQGLPVIFDEVFVGLHRIGPLTSARLLGSTTYPDIAVYAKILSGGLVPLSVTLASGSIFETFLGPGKVDALLHGHSYTAHPVGCNVALTTLNTLEKMQKRGDWDAAKQNWGIQASAAPPHSSTTSAQPWSLWSAEFVDRVSRLEERVSGVMALGTLLVVYLRTSSAGYDSAASVDLLARLKDAKIPGGPSAKGYNVHARPLGNVVYFMTSLNSKLEDLRALEGALWEALLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQW9</accession>
    <name>A0A2X0MQW9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C040g11847 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C040g11847</name>
        <name evidence="2" type="ORF">BQ5605_C040G11847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000118">
        <property type="protein sequence ID" value="SGZ32290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQW9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="1">
        <location>
            <begin position="236"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ32290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="315" mass="35156" checksum="6388D7D9EC418013" modified="2018-09-12" version="1">MLNCSTVNQRPALAQLWLIDLAEATDTRLGPDGADSRIQRSTLTKLESMLRTKNHFVREFASAKARAGWDTAKDTEMAMLICDSDTNTGDRGPQDLILQVHGDRCPDGRPKYQIFSSLHPKIASTSTFLFARSTKLGHSLPKDRDEAEGDAENGDGELSRSQLFAYYLHKRDEYFSIPHCTQRAFLAFVMTDTPRSRPINSTYLQLDQKNLRLTTSQGIISLTPNQVGCSVILGSTPSLFITVTCNPEWPEIKAALGPNDQACSRPELIARAFEAKLNRLCDDDVFGNKQRTGCLGDERRIVSLLYFVVCLFNLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQX1</accession>
    <name>A0A2X0MQX1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BQ5605_C026g10174 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C026g10174</name>
        <name evidence="11" type="ORF">BQ5605_C026G10174</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ27727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQX1"/>
    <dbReference type="STRING" id="796604.A0A2X0MQX1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF28">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="361"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="10"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGZ27727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="492" mass="53852" checksum="39D9E650CD9E42BC" modified="2018-09-12" version="1">MGISPALFNIALLTSLSFMLIGYDNGVIGGLTGTTSWNKTFDSPSGSTLSTIVAIYEVGCFFGAVIALSIGERLGRKKSLSVGAVLMTAGALLQGLAYGKPQLIVGRIVSGFGMGLINSTAPVLQAEVSPKASRGRYVCAQLSTLNFGIFLAYWLDYGTTRHYTTSFAFRFPLLFQLVIIVPIFVLSFIVKESPRWLANHGRDEEALAVVAALKGVDISSAEARESYQEIADAVAYEKAVMVTGWKQMFANDEMGTRRRLLIACSIQFFQQLGGINAIIYYANFLFSNSLGFDNDKASLLSGALFTVFFGMSFVPWALIDSLGRKPLLLGSITGMGIIFACMCGATHQIQYKAANSHGMGIFAVVLAFLYLSLFTIGFQATVWVYPPEILPLRIRAKGTALATCCNWIINFTVVEIFPIAIDNIGWKTYILFCVFNFSFVPVIYLFYPETKGKSLEEIDLLFSKTHATNIHEAKAERVEHREDAKTSEISSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MR26</accession>
    <name>A0A2X0MR26_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C019g08951 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C019g08951</name>
        <name evidence="4" type="ORF">BQ5605_C019G08951</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WrbA family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY23573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MR26"/>
    <dbReference type="STRING" id="796604.A0A2X0MR26"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000001">
        <property type="entry name" value="NAD(P)H dehydrogenase (Quinone) FQR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010089">
        <property type="entry name" value="Flavoprotein_WrbA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01755">
        <property type="entry name" value="flav_wrbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002999">
        <property type="entry name" value="PRK03767.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546">
        <property type="entry name" value="FLAVODOXIN-RELATED PROTEIN WRBA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546:SF23">
        <property type="entry name" value="FLAVOPROTEIN-LIKE PROTEIN YCP4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="251"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="269"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY23573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="313" mass="32171" checksum="D431FD6A5051EB16" modified="2018-09-12" version="1">MPAKIAVIYYSTYGHVRTLAEAEAKGAKEAGADVTILQFPETLNEEIRGKMHAAPLSTEHPTVSPADLELYDGFLLGFPTRYGRAPAQVSAFFDQTGGQWARGALFSKFAGVFTSSASQHGGQETTALTTIPFFAHHGISYVPIGFAAPQLTDLSEVVGGSAWGAAGVAAGDGSRAISEKETAIAEFQGKSFANLVNTFVAGKSALANHTLAKKSAETSTAAIAAKAVPASGPWQTWLFGSVTAAATTTTATDSTPYQVEPEAQQKPLPASTATHSAPAAPAPVPVPAATANNSKKSSGGIFCCGGKSSNYDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MRC4</accession>
    <name>A0A2X0MRC4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C018g08584 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C018g08584</name>
        <name evidence="8" type="ORF">BQ5605_C018G08584</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PLPL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY25126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MRC4"/>
    <dbReference type="STRING" id="796604.A0A2X0MRC4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07232">
        <property type="entry name" value="Pat_PLPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF66">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE PTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="7">
        <location>
            <begin position="354"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="746"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="816"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="5">
        <location>
            <begin position="385"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="770"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="828"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="860"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="874"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY25126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="890" mass="99846" checksum="6831A116981CAACE" modified="2018-09-12" version="1">MAEPLPIKPSKSTTKRPVPSRTQSKKGPTTNGGSGGTPGGPRSDMARKKRWDLHAGDLEWDWVDESFEQDMEVFGKACNEDTPSDGTDTPLEKIRAVSDFAPIREKVRRGPKRRRDIVREGWAYHVSRWPLLFIIFTVISIEFLAYVIVRQIVNLIEYFGSCKFRGPGIGGCCRTDAAGERSNLAGRGQRGKLRQALRRSRNFEEWKERALLLDAHLRFNEWKRSAPNAYYDSPLIRRVLRSLRELREKDDAEGVMAVLHAALRNNFAGSESFRLYRSVADALLQLANQKSKANDVRGLDSETFYGTKDLVQDYVDEVARSIEFVRKAPLDQVPLEIKHEFFRSSAKNLGATALCLSGGAGLGYYHFGVVRALLDTNTLPRVVTGTSAGSIVAAFLCTRTDDELRRLLVPELADRINACEEGLTTWLPRLLKTGARFEATHWARKASFFTMGNMTFREAFERTGRILNISVIPYDTHSPTKLLNYLTAPDCVIYSASIASSAVPSVMNPVVLLQKDKDGKVKPWEFGGKHKDGSLRVDIPLQALHLLYNVNFSVVSQVNPHIHLFAFAPRGAPGRPVAHRRGKGWRGGFLLSAAEQFLKIELTKNFRVIRDLELMPEFGGQNWSALFLQDFEGTVTIWPRSRFWDWFQLLSDPNRTELARKLRVGQMATFPRVKMIENRLKIERQIDRGREDVLKEVRKGKSGAGQLLGGRIDHRDSSVDRWDELSRVREKDDRGGKIKVPEEAVVLDDDDEEGEKGGTHIEPGPAASTPKDERSHSVIHNAERRKEILARLGLKNAETMGSTNARSTTEAAVFAGEDSEGEITKDHRTLRRRYSMGTLRRSKRSKSDGSRRTTMFGDETSSEDEEDDFLSLGQGSGGRGGGWSSTGSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MRL5</accession>
    <name>A0A2X0MRL5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C001g00722 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C001g00722</name>
        <name evidence="3" type="ORF">BQ5605_C001G00722</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY48979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MRL5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="574"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY48979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="597" mass="65824" checksum="9C23E3CE3C8E1448" modified="2018-09-12" version="1">MASPAGNRSSKVTPYDLIFGFTNTEVYRIPSKGFKARMITLAVLNVVLIIGILAYLGITYRERQRNTRRVSDASYQPKSQRAFWLFRRVDRSSGKLIIPNHRILGAAFGIAVAVTWIGLALNSIKVFVERGAMRDSFGWRAFLLMPMFGHGWITVWTSLTTFLMTTDRHSTFTVSSTLVNIFFIGVFVGGLGMAIICSCVNFSEGLKFWSAYLAFKARLENNDAAYPALPADAYNLTLQQAAEVQAAGVRYFRSGAYTFGPCIILALAIIVVNMAGLFLCRVLQKQIDYNKEQLISAITTEHQLTSSLVQETGMPRRPSTAVLKRLSLSKGLSPFESTASIEDFNGKRLSASQVRRMSKLDARSHCKDRARTIIVLTRARWELLLFSINAAVISMFIIGILTYLTIICHDLTIVTGTFSRFESAVYMSGWFYTTLSLLTLVFLLFQAFQYRERARTSVRTLGGDLGGGTSSNSVGGAIPAAQAMSETGAEPIVRPSHSRSCSFALPPPPLDRRGRGESDVTGRRGDVTHLFGRFANAWARRNASINSTNTKPALGVNMVVERAVTEEMAEEEMSATTSSTEEQVTQEKPAPTSASQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MRM8</accession>
    <name>A0A2X0MRM8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C027g10425 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C027g10425</name>
        <name evidence="1" type="ORF">BQ5605_C027G10425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MRM8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ28725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="225" mass="25205" checksum="3452DB10C1547D14" modified="2018-09-12" version="1">MLPHVFPELLRSTEVLVIPPTLPSLHPQGLSDDARKRLKKFGAIIDLYRRPQTTGDPVNPGLQPESLLEKLWADVSASSPIASVLPQPAAVRTAIGECYFLRPCTYTFLGATRPFTIKALRHFINEARYPSLDDGSRLKCPTDLTESQKQQFWIWLNSQWATAIEKDVHWKLIFGATPTCVLQHHHGDFQPGEVDSSQIMLGLPRVRGGSRDSRTYIVVRVVQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MSA1</accession>
    <name>A0A2X0MSA1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g03768 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g03768</name>
        <name evidence="2" type="ORF">BQ5605_C006G03768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY53519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MSA1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY53519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="302" mass="33068" checksum="B2330B385FB930D5" modified="2018-09-12" version="1">MNMTIAELLAFDVAPADASLHIELSKDEHTQYSTLSSTRGPTSSCSTQGRPMESSDPTRGEAGVGVSNTEEGRSTTHSCVLKGLVQSMGPSRCEDMAGTTRSLNLRFRRMPILRMAAFKDKQYGALAQRYPHFGSLDGAVTAATPLEIGSLICFGLKCGMHSLSCDQTVYGEEALSIGIGTRQSDTKPLQPRHARLVGSTLKCRPRAHMPSKDLPPFGACPACEMPPAEPLQAAQMPPRKQGAQLQQKGSLTTKQRASQQSKEGLFEAWSHAQHQPKRRAPQATFDRPRRVRKRSERVFEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MSV5</accession>
    <name>A0A2X0MSV5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C048g12350 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C048g12350</name>
        <name evidence="1" type="ORF">BQ5605_C048G12350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000110">
        <property type="protein sequence ID" value="SGZ30405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MSV5"/>
    <dbReference type="STRING" id="796604.A0A2X0MSV5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ30405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="66" mass="7581" checksum="99936F2B5B592DA6" modified="2018-09-12" version="1">MVRSFALVKIYGMAREGRSLVSGQYPRVKARLVSLYWIAFLSAPTAQQPVLEIQPREDIRRCRGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MUE2</accession>
    <name>A0A2X0MUE2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C075g12916 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C075g12916</name>
        <name evidence="2" type="ORF">BQ5605_C075G12916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000128">
        <property type="protein sequence ID" value="SGZ34760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MUE2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ34760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="325" mass="36125" checksum="B434ECDEE744B73E" modified="2018-09-12" version="1">MARGRRKKWTPKAHAPPPISERKARLQSRRTRLQVLDLPSAAASPPAFSAPFPLEPTHIHKSSSKPNWKSSLEDVFEDVEPAGSSQRGFSDDVDATHSHSPVRLRRSINEVDLSPGSEKKLYEPQIRQRVDYSSLQSRRSMTSLQGDNPKSLDPPVPESRPHGETSDYGTVAGSAGADPEERDDTLDHARMDSKVFCADLVQTAPVRDSPSSHQFSVASSICSSEESNTHESDDLLGHDDSALNMEVYSAGHWPSPSKFRSATCGVTAYEYNGDLFLSLRDVFNGARNMFLWRAHNHVLHHQAQRKQSTVPWTPDRSKLKPGLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N0Q6</accession>
    <name>A0A2X0N0Q6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C009g05666 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C009g05666</name>
        <name evidence="2" type="ORF">BQ5605_C009G05666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY83961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N0Q6"/>
    <dbReference type="STRING" id="796604.A0A2X0N0Q6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022036">
        <property type="entry name" value="DUF3605"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35020">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-INDUCED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35020:SF2">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-INDUCED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12239">
        <property type="entry name" value="DUF3605"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY83961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="243" mass="27809" checksum="B8D10B58FAB71764" modified="2018-09-12" version="1">MAYTEQATIVPHDQDPAIDELLQEARRLQAAHEPIFTWKQLIDIILGQGRLGELIRHPTVERAYEERFNPALRKAHGSVAAYLRAQLRWEHHELSSGTDYWIRTAPAQVRLNDWAYSVPKNVVHYVVWVPTPLLHADLCQPVTTSRESSAPPTKSLESESEFDPWEQVKRNGLGGRTGAGGESREDVGPEREISAFVKERWSEDEYDTLWFANPPELQSVRDLAHFHVLVRQKDHLGRAELPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N161</accession>
    <name>A0A2X0N161_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C009g05826 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C009g05826</name>
        <name evidence="2" type="ORF">BQ5605_C009G05826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY86542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N161"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY86542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="417" mass="45967" checksum="EE3E24ABF7FBBD12" modified="2018-09-12" version="1">MPGQEFSAFTPIDESLVPADAKVLGSRFVFRTKRDQHGQVKSYKGRLTFAPVAKFTSIRALLALAAAHGYHIHQADIDKAYLHGKLDAPCTFAGRIWNDEIDSALSALGYVATESDHCVYVRTTAPLPEIERTLQGLEQRYGVKRLGEAEYVLGIQIRRSPDGSISLSQEQYLKDVLARFGMSDAHPVATPMQPDLRLEVELQPTPFPDRTRYLQAIGSLMYASTGTRPDLAYTVGYLARFSHSPSAAAWGAVKHAFRYLAGTLSHGLRYARGNPAPLLGYSDCNWGACVLSSKSTMGYTFVYAGAAVSWSSRLQSRVADSTCDAEYLALSQAGKEAIFLRQLFGELGLSSSKPVLIYGDNQGANALTKNPVFHARTRHIRLREHFVRDMMTADIFTKALSRDLFARHRGRLGICAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N2R3</accession>
    <name>A0A2X0N2R3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BQ5605_C004g02744 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C004g02744</name>
        <name evidence="12" type="ORF">BQ5605_C004G02744</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY67108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N2R3"/>
    <dbReference type="STRING" id="796604.A0A2X0N2R3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15853">
        <property type="entry name" value="SNARE_Bet1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039899">
        <property type="entry name" value="BET1_SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="107"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="75"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY67108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="204" mass="22449" checksum="CADAD342CC8B2C45" modified="2018-09-12" version="1">MGISTVCGFKAVTGCDRPISGQLAANKRHVRPRLNNATRLGSALVSSPDLVVSSRMYGAERQGLSHRENRAALLASSNPSSRSHSPLPTHYPKHLQGPYANASRTADDLESQNEDNLQGLSAKVKLLKDITINIGNEVRDSTKLLSNMASRGNNDQYAETGGFLSGTMGKMGRMAKRQGGQWCLWMMFLLLIGTIFFWTWLLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N6Y9</accession>
    <name>A0A2X0N6Y9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C009g05438 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C009g05438</name>
        <name evidence="2" type="ORF">BQ5605_C009G05438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY81013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N6Y9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY81013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="340" mass="37368" checksum="F63A9DF70E3D7AC0" modified="2018-09-12" version="1">MVKNHPTYADMVYYNRGLEFELMRSAARRPNFDIACAFERGFLFVGISDEPNRKLENSKLKTRNSTTRKLEDSLQLTGARNLAPLILCFYPFSTKLAHVKIKKYLQEVYEIDMNKTSSKLALKRALEHAVDEGLLQLIGASYKMTATGLHHLQGARFSSEPDPKKPKKEIVKKPAVKKSTTRIKTVMKARVKAGTLAASKKKTNAGKTKKTNGLVMNKVKTRVKTSADAKNKDKLKTTSNKIVVVPIKGDAEALAEPTLLDERPPAEGEEPQTETEREEDEDGELPAPQVGGLEARVAVGGKDEEQVTPEKNKIHGRGSGGLDVGQGPGAPRKRSAHGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N760</accession>
    <name>A0A2X0N760_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C022g09583 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C022g09583</name>
        <name evidence="2" type="ORF">BQ5605_C022G09583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ23075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N760"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="1">
        <location>
            <begin position="291"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ23075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="770" mass="85532" checksum="0D793C34EA8E8B50" modified="2018-09-12" version="1">MADIFSRSIEATMLQPRGAVRSCTAYNFGPPDRAATRPGAREVGLVETRLLLSSRSFHLCHITTRTSLLRRTTDFWLVLLSEGVFRLPTATIILDPAGIEYLRTSSSSSKITQALIDPVRRTKPAPPRLPPVVPVKLVKMAALNTATNLATATDQRIKTEVQGRVESSKALQAYLEEADSVIDPQVEAIRWPTEVEGAHWGTEKGMGTFVKRITEQIKEEAEIDRCLVVCGSSNAIVPTSAEQVRSKDHCADVVLLFPGASTPGKVRSWERVDKVWDALALTTGSTLIDERNVDDVLVFGEVKSNPEKKVEARDQAYRRFYRATSIKPIRKWVFAFTLCGSKLRVYIHTPSGMVRSEPIDCASESGLASLKRLIVRFLRHDLDTLGAIAYAALFPCELNMGRLPPQGFPPVPPISRPPSIKLLCRQLVHPAMFGARPSVYRIELDETTSDLSRATQPTFVSDLQPTPLPQHTMRIAFPDREEIQRAQRLDGLVRVTRSTRPDDVSSIAVRKIAFIDIDNFWTVPPPIGRSGHTNFVPRTLQCDVFEDLYRTVLEIESTSAMVDFNIGIHNLLPRHLSDGNIMLDRAGKGVLVDLDGMVDLGSASASWELAESAGVLAFLAKAGHPDEGGRWAIAPHSMWQLIEGLANVNQFTVCQRPGGPGASMRMSPKACLLWTKFNHGTSQIAIRSKSLHYANFANATFELMYPPFWADLPRLFEIMSRYCCLRGPPGRISSVRLREQDLGMRRQWGPGGNCSLDRLSAELKRLRARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N8K9</accession>
    <name>A0A2X0N8K9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C038g11740 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C038g11740</name>
        <name evidence="10" type="ORF">BQ5605_C038G11740</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000061">
        <property type="protein sequence ID" value="SGY92458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N8K9"/>
    <dbReference type="STRING" id="796604.A0A2X0N8K9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF3">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="506"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="539"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="569"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="186"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY92458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="596" mass="62891" checksum="AAB56AC26588526F" modified="2018-09-12" version="1">MKLPTPPLQAHIPASAFPAATPPQAQGAAAMGTPPLSPFESPNVSRPPSPTTAASSTMLFDPYSRSSSMKRLLDHHERSLSRGKDPAYKLQPQKQQRSRAPSSLLSKLVALLTLSDTAASTGPHTRGRRRSISHAAAGEEIELGNLHVVGAPMTLHSTAASLRSVKTSSATHSAARQGWFTRDRAQLYIAFAMIFMVGSNDSATGANLSSMQEHYGVSYDEISIVFLANVAGYFISCVLSSFLSHKLGARYALVCAAVVWSIGCAILIVWPPFGVFVLSLAMLGFGGGLYDALLTTIISHDENPVLMSWMYSCFGFGAAVSPIVIGTFVDKGISWNLYYYIPTGLSIVFGLLAHIIFQGYEAPLDEAVVPAAAVAAGAEDSAPHPGPSVGEIFHGRATLSATARMKRALSLKVVWVAFLLITLAFGTGDTLSAWMTVYLSTIRAAPEAASRYMLSGLWGGIAIGRVVVPLILSKRLGERTFAIVLLMLAMSMLAIAWGVRNYKIDAVALAFVGVTIGPVTPHVLSVVGARVPPSLKASVMSLTIGAGLVGSGAGPLLFGVIAGRGWLNSLPAVLIVACGTACGSWMLVPKNTRRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NFV0</accession>
    <name>A0A2X0NFV0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C027g10302 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C027g10302</name>
        <name evidence="2" type="ORF">BQ5605_C027G10302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NFV0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ28287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="105" mass="11106" checksum="B4C8B31BF9DCE7F2" modified="2018-09-12" version="1">MYSPITQRFEADSAHVVSSEQNGSTFPGDDHPSSAAGVRTIPAPSTQPSFKDQVIGNAKKFAGQAFGREHEKITGEALIAGHGKDKAEQIGQEVKAATEQQAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NIA3</accession>
    <name>A0A2X0NIA3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C043g12077 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C043g12077</name>
        <name evidence="2" type="ORF">BQ5605_C043G12077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000117">
        <property type="protein sequence ID" value="SGZ32109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NIA3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ32109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="201" mass="21606" checksum="8D17BDF2A24586BC" modified="2018-09-12" version="1">MESTRACPWELRADSIEIRRKGKATGRNGDDGQTLAKVKVGYIFRAAMVPTVQDLMKTVEQALDEHKKEARGEVESESATTSSNPSRSKRPAGATGAGSSVAKKRAKLTDDATLQQLPSATPDQINKTIATPLAKKHGRGNLPKHASPKTVATQPVSKTLRRLRVPASDTEYYGQSYQSQAIVGFEKLGAAANAGGRAHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NKN5</accession>
    <name>A0A2X0NKN5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C090g13048 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">BQ5605_C093g13068 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C093g13068</name>
        <name evidence="2" type="synonym">BQ5605_C090g13048</name>
        <name evidence="2" type="ORF">BQ5605_C090G13048</name>
        <name evidence="3" type="ORF">BQ5605_C093G13068</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000004">
        <property type="protein sequence ID" value="SGY11541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000005">
        <property type="protein sequence ID" value="SGY11562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NKN5"/>
    <dbReference type="STRING" id="796604.A0A2X0NKN5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025340">
        <property type="entry name" value="DUF4246"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049192">
        <property type="entry name" value="DUF4246_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119">
        <property type="entry name" value="IFI3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14033">
        <property type="entry name" value="DUF4246"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4246" evidence="1">
        <location>
            <begin position="148"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4246" evidence="1">
        <location>
            <begin position="337"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY11541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY11562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="624" mass="71009" checksum="0659619EABBEA7DF" modified="2018-09-12" version="1">MEGPSKKTTPLAKIFPSPFSFQGSQYSGGKTPILARRECACSPLVSAGAKHRLRHTPSEFQPQKHIGGVVWLMFEAAATAWSPYTLHEIEMKALSYSIRSNKADWQTKRLSREIRTKWAMEALEQSAEKAHMAFKQMTLERQPLTFWMVDYVLEELEQHARMERVVDGQWRESCFDAIFESDRLIPDGLRSALIRQVAKLENVPEEQKDWHPGSKKQVLDLVHPSLYPLVYKQSVVRKSLDGEMQPGTTAASAVTLAEAPAPKPSSTSAIPTGFDDADETSYLSSQYQWLPSNFTLDENGGVSIDGYINNLHPDDHADFSEFDEDKWMENYGSDFEEAIIQDALDEARERWEMSREITLPAPQGVFHPAPEDAIRRKIENPTFTIKGRTVQVIVKLANIVLTPDQPTYTGGVWHVEGMKNESIVATGIYYYDQVNIDGSSLAFRGTFDETELPYEQNDESRVEIVFGIHGDGPTVQSYNSAATTHNRCLTFPNIYQHRVPSFSLRDRTKPGHRKILVFFLVDPLRPRIPSTRDVAPQQREWIERALCESTPGADTEADDSAPSRGSLIDRLPNELWDRILDLTDGLITQDEAKEHRNKLMFERKFKLKEHSTEVYEREFSLCEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NQG6</accession>
    <name>A0A2X0NQG6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C015g07751 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C015g07751</name>
        <name evidence="6" type="ORF">BQ5605_C015G07751</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oligoribonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NQG6"/>
    <dbReference type="STRING" id="796604.A0A2X0NQG6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06135">
        <property type="entry name" value="Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003765">
        <property type="entry name" value="PRK05359.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046:SF0">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="5">
        <location>
            <begin position="38"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY17330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="224" mass="25150" checksum="4AA771CECF03C9ED" modified="2018-09-12" version="1">MSPSGPCQGRLLWIGAEMPIDGQHATLESRILEYRGNCEMTGLNPYLPPPTLGQGEPFQPDRILEIAMIATDTDLRPLDEGLEMIVRTERHVLDSMNDWCIKQHGQTGLTKACLDSPHSLKDVDAACRAYVTRHFDAPAVIAGNSVHADLGFIRKDLPFLSSTLHYRIVDVSSLKILVAQWYPSAPKPPKEKSDSQHRAMSDIRDSIEELKHYRCHFFVDTDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NRS4</accession>
    <name>A0A2X0NRS4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BQ5605_C014g07626 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C014g07626</name>
        <name evidence="12" type="ORF">BQ5605_C014G07626</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NFX1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY19349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NRS4"/>
    <dbReference type="STRING" id="796604.A0A2X0NRS4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06008">
        <property type="entry name" value="NF-X1-zinc-finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034078">
        <property type="entry name" value="NFX1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000967">
        <property type="entry name" value="Znf_NFX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR, X-BOX BINDING 1 NFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360:SF12">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR NF-X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01422">
        <property type="entry name" value="zf-NF-X1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00438">
        <property type="entry name" value="ZnF_NFX"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="R3H" evidence="11">
        <location>
            <begin position="856"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1048"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1168"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1050"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1179"/>
            <end position="1202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY19349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1202" mass="128467" checksum="572D98B3AB1F86BB" modified="2018-09-12" version="1">MTRDGNSSRRGRGARGRGASAAPSSSGGTRGGRGNAHTLRGGAAGSQAVSGASSAVTTDNEGRADTSHEANHQARSKAGNRSSRGAKRGGRGRGEGHAGSSTPASTSRRSHFNATLSSGNDMNSSAVPFPAPSSSSTAAGQAFPIVAAPVSQTLLERLTTELSDGSHDCTICFSTVSRTTAIHSCTTCYTPFHLSCIKEWATRSVTDTAERAALMATRDSGPRPSAADLSGHWRCPSCQTRFGAADVPKRYRCFCRRLVDPSHRPPATPHSCGQPCARPRPDGCVHASCGLLCHPGPCPPCPVVLDLPCHCSKENMRVRCSATHPAAGLDSGTVASTTASLAREELLCCKNTCDKLLGCGLHRCARICHPGDCASCEVEREKVCFCGKSTVVEACGAGGRDDRVEGCRVPGRDDSPWPGEFSCDKPCAAPYDCGEHSCESKCHPHTSELPAKCPLSPSLVTTCPCSQTPLDVLLPTPRTSCTDPIPTCAEPCSRIFDCGHGCARPCHPGPCGSCTTPVSIPCRCGSTKTVRLCGNRYQSDGKTPLSEVLCQRICRSLRNCCRHQCNRQCCPLSYQEALHVGKGKNKRRNALDDFEQHDPLGIHECDRVCGKKLSCGTHFCERKDHKGPCPPCLDANFEEIACHCGATVVLPPIPCGYEIRCKHPCVRPSTCMHPQVPHQCHENPECPPCPFLTIKMCACGKKAVANVRCSQDSRKVSCGQRCGKLLGCGFHRCQKPCHLPGECESCVQICLKPRKLCGHPCPEQCHVPASCPETKPCIKMIEVSCDCGHLKQTTNCGVCTDRPDGNNSKILTCSDACAIAKRNAALAEALQVERREPKVKQVEYDPQTLSFYSTNVAWCTSIEKDLVEFVSTDKPTLHLPVMKRPQRQFAHELAELFDLRSESLDEEPRRSVVVHRQSNTGIPVPNLADALAAQRKSATTLSFASLRKALPETRRHVNAFLLEGVLGFDEAMLRDIATPCLKGLQPFALTWTNDADVLITIESKMPSAADLEQRVTAAETHLRALAEETGFCTTVEAVAVTDDGRITRGGWTSVQSRSNPSGSRAEGGGVRSNPWATHAPSISNNTFAALASSSNASAGAAPSTQSAWGRSRDDAGLIGVGYHRPPRAVIAPGLEVARPDPAPLLKKVSSHLDASRLTATADSFVPAGTAQSGVKAEVNDEDVPDDWDQEELSEVQEAQEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NUY9</accession>
    <name>A0A2X0NUY9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C120g13290 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C120g13290</name>
        <name evidence="1" type="ORF">BQ5605_C120G13290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000028">
        <property type="protein sequence ID" value="SGY27780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NUY9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY27780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="212" mass="23454" checksum="1EA0A33281DC4C9D" modified="2018-09-12" version="1">MLPPRQLPTLLLAVPQHHLELPTGSSPLAPSNHPSNIPWNAAVLKVAALIRCNWLMSLVNCCWVEPRLLARPRELGRSRPVGDPKGPWGGRRSSRLGTSRFWWVRCRRKYLADQDRPVMAVSTLVPPIDRRQRAVVEIAAEESKVGALRPVENSKGGDQDSSVECRVGAQNLGVDQGRVGGDQSQTVFADEGLALVLVLDTLPEFRFDEVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NXV3</accession>
    <name>A0A2X0NXV3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="19">BQ5605_C004g03156 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="18">BQ5605_C014g07411 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">BQ5605_C014g07411</name>
        <name evidence="19" type="synonym">BQ5605_C004g03156</name>
        <name evidence="19" type="ORF">BQ5605_C004G03156</name>
        <name evidence="18" type="ORF">BQ5605_C014G07411</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY18609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY70500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="17">
        <location>
            <begin position="447"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="728"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="783"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="820"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="SGY18609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="SGY70500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1401" mass="153689" checksum="16E71B4CDFBAE206" modified="2018-09-12" version="1">MSAAGAPAPDAKLREPTPDAPPLRPPTHSAAFATTELLRNSSGYRDWVLAIRSRLPSGVVRYLNTGVPLESWLLLAQPSYQCGHLRARPSLYFFTLRNMSDAGASAPEAKLREPTPDAPPLRPPTHSAAFATTELLRNSSGYRDWVLAIRSRLPSGVVRYLNTGVPLESWPASYVPLWDHYACSSICASVDSQTVLPGLSPYLDESLAAPKVWQALRERYGTVSAVDLLPVIQRLFSSDPVPVTPDLFLQFRDSFENDARLLQDSQVTVNALLASHLLARLPSSFDAWRTTFVADQGDSTAMPSATKIFTRLYRDVKARPVDTPVAAVATPQARHGCSRPCPNPSCRKLHWLRECPDTAWAAAYRACRTAEKKASQPVASPTPCTPKALLAVPANVSLLTLHRRLAHLPVAQIKNIVQSGLVTGVDWVYKDQELRDFYCNACLASKAHALPFARSKSIASGHLDLLHVDVAQMPRPTFGGHRYMLVIIDDFSRKHWCILLALKSDVFPRLRDWILEVENATGNKVKTIRSDNGGEFTLRNFVDFCASKGIRRELTIPYTPQQNGRVERSNRTIKEGILALLYSSGADSRLWGEAALYYVHCKNLMPHAGIGGEIPDTRWHGFAPDISTLRAFGCRAWHHLPSAKRTDLDPKAVPLLFVGFDQHAKAFRLFEPSTRRIQLSRNVVFRESEFPALRPAPDVRAEPIPLPVPVDAYPDQVDPLEPSLVASPRSLAPCAEPPRPVPAAPDQGPHRPAPAREVPDQDSLAPPAPDQGSPALELPDPESPASSASDQGSSDSAISTPCPSPRPVASRALPAPPSPARSDSPDPIDLLPRPRDVASLCQAQEFPDDVDDALHSPSAVAYLASGAAALIETSPADPAELIAPACDPPHWRAAMATPQADEWRLAARDEFDSLLRDFSAFTPIDESLVPADAKVLGSRFVFRTKRDQHGQVKSYKGRLVARGDSQCSGIDFDETFAPVAKFTSIRALLALAAAHGYHVHQANIDKAYLHGKLDAPLYIRVPDGIYMPGKVLQLHRSLYGLRQAGRIWNDEIDSALSALGYVATESDHCVYVRTTGDVHHYIALYVDDLLMISPSLPEIERTLQGLEQRYGVKRLGEAEYVLGIQIRRSPDGSISLSQEQYLKDVLARFGMSDAHPVATPMQPDLRLEVELQPTPFPDRTRYLQAIGSLMYASTGTRPDLAYTVGYLARFSHSPSAAAWGAVKHAFRYLAGTLSHGLRYARGNPAPFLGYSDCNWGACVLSSKSTMGYTFVYAGAAVSWSSRLQSRVADSTCDAEYLALSHAGKEAIFLRQLFGELGLSSSKPVLIYGDNQGANALTKNPVFHARTRHIRLREHFVRDMVSMGDIVVQYINTGEMTADIFTKALSRDLFARHRGRLGICAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NXV4</accession>
    <name>A0A2X0NXV4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C014g07710 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C014g07710</name>
        <name evidence="2" type="ORF">BQ5605_C014G07710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY19634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NXV4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="674"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="868"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="897"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="918"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="994"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1008"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1028"/>
            <end position="1052"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY19634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1066" mass="116172" checksum="7D1A41AC12258FC5" modified="2018-09-12" version="1">MSESSGEEEGSLSSVASFTANAAAAQGAPEDDPADRSTELLVSGPNVTRGRSALETFRINKGDVEIRVSAQSRQGPHEDWCSCTKLPVQVRQSCPTPDAALGTRASQSHLAQVSGAVDDFVRNWCPGNNPDHWSYKPRISMFWPHVILRQHPNETGEAFQIREGYLIDQYRAKAAEIITNPQADNCIELDDGHELDILAGQHRYHVAGRVHERCPDRPEYARLSVAVYRRAVIDDPDALFASVQGTNRQEHMRGFSVYEMLQYALLCGVNELADSELRIPGIVPTPEAIAEARSTRFREIATDNPSVSTELALTIARLLRHPVWCTTLATLCQDSSAWMTIRGLCDMNNYGWRALTPPGCSLAATRMVLSIDAVVSQLGVDTPEEEFLAYQGLSPAAIDDAKKPDNPDLSLPRPRLDAVLNLMSKMRVKVVKVPNTEPAQYVFDLPDLMHEITRQVPPPGADAEFVRLWLMFFTPKTIKRLTTPGVINLAWFLGVGTLEVKKGPPEPRKASHSDVRAAKKNVASAKADNLLAPADTKPHATSADAEPNATSMHPKSFLPIINKQEKSRYDAMVADSCSWACMPMWSKIRAASDTHFDFFLNDLVVPIGSHAYTKNLKNQGIKWSGIKGIKAPQTITHLMKEWLNSKFLDINVFTDEFLPIPANVRNKWSGVAKNARDAHHHTPAAAAKANSSTKDPLPKLPHAVRLDKYYHHFIKVIFRQSAMKKHVLDNAFEAAPENTSGSEEDAGAKTSFKGKASKARAIQTQARTLLEDSRAIDLGVLACESFTVRPSGTQLDAALLAFLSSLVASGAVVKFKATPITVKKLDQHLKCFRAEADVITTMEGYLDWAAGPEYKSEEEDEEVVAGKGKGAVVKSGGRHCTGAPTPTRKGGTQQKVKPMDVDLSKEVGTDAEDCPAVSNKSAASGRQLPVSNANYGDITGLAVHDSSSPMPLEPELRDASESPIKNSASDPQRAKGAKVAPPVSSPMPVRLNPNRFNGSSIAGPSNDKMGKAESDSRKRKAERDISPPKTKQTTLATKPTTTSSASKQSKLTAMQKRRLNTAPSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NZD4</accession>
    <name>A0A2X0NZD4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C019g08852 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C019g08852</name>
        <name evidence="6" type="ORF">BQ5605_C019G08852</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. Binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY22753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NZD4"/>
    <dbReference type="STRING" id="796604.A0A2X0NZD4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.33.40:FF:000002">
        <property type="entry name" value="10 kDa chaperonin, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="entry name" value="GroES chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772:SF0">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00056825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY22753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="136" mass="14429" checksum="4195DE216DEB791D" modified="2018-09-12" version="1">MTRPRSTASHRSIAFPHPHANRLQPPIRPAMQSLTIKSIKSLAPLLDRVLIQRAKVVEKTASGLFLPSAANNSPPPEGLVLAVGPGAPGKDGQIVPVSVKAGDRVVLPAFGGVGVKVGDEEYQLFRDSEILAKLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P0J2</accession>
    <name>A0A2X0P0J2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C018g08746 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C018g08746</name>
        <name evidence="2" type="ORF">BQ5605_C018G08746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MYG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY26563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P0J2"/>
    <dbReference type="STRING" id="796604.A0A2X0P0J2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003226">
        <property type="entry name" value="MYG1_exonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215">
        <property type="entry name" value="METAL DEPENDENT HYDROLASE - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215:SF1">
        <property type="entry name" value="MYG1 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03690">
        <property type="entry name" value="MYG1_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY26563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="332" mass="36955" checksum="CDEA488494AF90B3" modified="2018-09-12" version="1">MLCRPTSTLRSYIHHAIPRPRSCTRSPPCIPMSTASVTKKPRTTPLIGTHSGTFHADEALAVFLLRLLPEYGQAEIVRSRDPTVLDECTVVVDVGGTYEPERLRFDHHQRGFNETFGHGFVTKLSSAGLVYKHFGRAILSHVLDLPQHSPSIDTLYLKLYADFVEAFDGIDNGIAAQSGPSLYKSRTDISSRIGHLNPRWNEPYSDAILDERFLKASHLAGTELLERVDYTAKAWLPAREIVLEALQSRKEVHGSGRILLFPMFAPWKAVPMTQESFESRHPLPEAWRGVRDDALSKLTGIDGCIFVHAAGFIGGNQSKEGAMKMAIEALHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P0Q4</accession>
    <name>A0A2X0P0Q4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C086g13019 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C086g13019</name>
        <name evidence="1" type="ORF">BQ5605_C086G13019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000037">
        <property type="protein sequence ID" value="SGY28490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P0Q4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY28490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="208" mass="24064" checksum="3D656362A209FA70" modified="2018-09-12" version="1">MIRIYCPSLDNGSRLKWPTELTKSQKQQFWIWLNSQWATAPTCVLQHHHGHAASDGCPQCGQRDTFMHFYFECDHSRDFQPGKVDSPQIMLGLPRVRGGSRDSWTYIVFRVVLAIALNKLYRARWHQHKDQIPLPTPYFLTRKVRSHLKFRLRRLPDGELLDQMIRVVGAQMIGITLLVLSGVWGLHGSSGYDFTYVQPPFSRNIDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P2B9</accession>
    <name>A0A2X0P2B9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C002g01728 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C002g01728</name>
        <name evidence="1" type="ORF">BQ5605_C002G01728</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY35118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P2B9"/>
    <dbReference type="STRING" id="796604.A0A2X0P2B9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY35118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="239" mass="27284" checksum="0D7C4DF42D1DDD21" modified="2018-09-12" version="1">MAVTVNTPEKDELVHLVKFDPESELHVAELKRQRIICGWNEDLVEGWCNKARRGLKGLVWVMRSSTPAAQAYFAAKPLPELEKLNLTNDPEARSPRPISENFRPIGHASLDWEDMLNDETLASKKLGNITFTSFFLLLSQQGLGLGSLVMDLLEAMAKTPEYGAKYITLTTLDGDLARDPAWWERTLGLAFDPSKRINEEWYARRGYEVLRKNVPRYPELHKKTGEQVILNAVYMRKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P4X4</accession>
    <name>A0A2X0P4X4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C003g02541 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C003g02541</name>
        <name evidence="7" type="ORF">BQ5605_C003G02541</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY41698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P4X4"/>
    <dbReference type="STRING" id="796604.A0A2X0P4X4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="461"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="518"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="464"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="518"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="592"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="602"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="681"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY41698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="775" mass="85531" checksum="DAF178040F325465" modified="2018-09-12" version="1">MLATLIATGVTATVTGRLAGELPGTEPGGSGTNLPRAVLIVATASSALATVLSLLTIWLQLKNYRKIALQRLVVRILVMVPIYSLSSLISLYSLDLAFFLDAVRDIYEAFVIYCFFNLLVEYLGGERSLIILLHGRPPIRHPFPLSSILPPLDVSDPFTFLAIKRGILQYVQIKPFLAAATILLKALGSYGDGNLSKSSGYTYISIIYNVSVGLSLYCLALFWIATNADLKPYRPMPKFLCVKGIIFFSFWQGFAVSVLVKLGWFRSNRYETEALSLAIQDTLVCLEMPLFSFLHLYAFSYTDYIDANHLFSGRLPIWYAIRDAFGYKDIFTDSITTVKGTGFSYRTFEPAAGGIHQGLGRDRRVAAGLRYARGGQVKYWVDLPGREMDAHGRKGKTALVARPLHAVRKALEERFDAGQGYAPLGEEVARKVVGDDDQGTWVREHGYDEEDWKRWFASRGADGVDGEAQDGDGDEESLGFGEVGEEEEDEDERLYKDAKGLEFGDWRYPVLDASKEEARRKMRMQEEERLEAGRFVSFGREGEGRRRTRGKGKGKGKEKEHLGRGSRGFSYGALVEPETETSTDAEVDKPSSSRKRRGSSSHRREPSNSADHPKPEGKLLIHGAKHVLHAVSGGLYHSPRDEEGGEGSQSKKSSSAPPRPDRIASGAYDLVVADHEAEEEAQIKDRRKGEPGAAKRRVYRQIYKPDDGEAEGEGSKEPAFPIQPLENEIVEISRVEGEGDGESGEGTMIVVREQVVTAVETDGPEGVPPGSPSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P6U0</accession>
    <name>A0A2X0P6U0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C001g00755 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C001g00755</name>
        <name evidence="6" type="ORF">BQ5605_C001G00755</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY49219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P6U0"/>
    <dbReference type="STRING" id="796604.A0A2X0P6U0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328:SF15">
        <property type="entry name" value="BHLH TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328">
        <property type="entry name" value="PROTEIN MAX MYC-ASSOCIATED FACTOR X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="5">
        <location>
            <begin position="1019"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="98"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="164"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="231"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="621"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="847"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1046"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1159"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1103"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="241"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="338"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="621"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="698"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="726"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="753"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="795"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="847"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="885"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="950"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1018"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1159"/>
            <end position="1168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY49219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1238" mass="128714" checksum="E3487802371A3B41" modified="2018-09-12" version="1">MSFHASSTVASPAYLDSTNLGNIASPHPELFAYTSQQHPHHHQHQHHGNFPINALAQQPSSAAHQQGSMNSSNLNMTSPGADFADLLAEFTLPANALSPTDPNAMHGNSPGVPPSYGDHHEALVEASPSHGGGGGGGYQLQQPRQHHRERSAQELVLQHIGFSLAPSTSTSTPSAQPSSPNPSHSGGNTMSNAATDAANAPSQITNVIATMDPAARSQLLNALLALKQQHQPNNPTSATHSPGAASPVASAGVAASPRHRSPSRMASSHPAAHENQSSSQRNRSSAPTYTNSPLMTAHNGPSRSTSSSAQASPMAYYGAGVESNVSTPHAYHSHHRSGSSSTSTGNSVAMASNSSNSYLHQIATSLPPSNMPSPLTSPYTSVQQKPSQQMFDALAMQQHQNVSAQLQVHSASLVAANQSSQQQQQPMQMQNAFGMPGYEMEQSELSRNAPTSEVQAAIEMLTRVGGNGGVGGGSINGDMNPRGESSMTGGSYATHPEGDDWTGSNEFMFSPLMSPAMTPQSVFTTASSLPPSGSFPPSKNALVSPAEFFSPLSSPAIMPQQFNDDPAAAAIWQAQQLQNRTLLQGLVDQTGALGFDHSNLAAMQAAYSPYLGATMPGNATSATGSPANAAATASPRLDSSDAGLSTAAGAGRRGAGSKKARPSPLLKPTPDGQLVRRGTSKKAAGGAGGDRRSASISNGARSATTSPFLGPSATGRNSVAAPAANGGRGAAGGAILGSQRSSPLDDGMMNAISADSPSPVDLSSSSAVAETSVGASPAFAKNGSQLMGPPPLPSSAATSRRSSIVQNATPVQHQDATMATPDWLHQAATPATFMNLPNNITGVSSLSHNSIASTSDGTQQPQDSNALLTPPDQEAGSLANAARDSTSPSTNSTGSSGSGPPTSSSSKGRSTKSALALTRKIAARPIKASRIAPAPPKAKNTLTPSPTDVAKVKEGEKEKEKPTEKRKYKGKGKEKESGAVKATEMDDDADVDNTSTALKDDVLGDLNSSTSGPVVGGELRRTSHKAAEQKRRDSLKQCFESLRRILPPIAMNATPDEEKRPGEGNVGGQRSGSVDPENPNRGVSKVALLRRSNEYVGMLHDRIDRRDGAIDALRRRIAELRERLGEEDVEDDDYIDGFELDALDKDEKKAGNVFFYENLDDDDEEEDELRPKGKNSAAPKRTGSLLRRKSNAAAPTDETSAVGKDAKDRAGGMGRRSTRNSLGASEHESMTMDVEAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P6V6</accession>
    <name>A0A2X0P6V6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C005g03573 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C005g03573</name>
        <name evidence="2" type="ORF">BQ5605_C005G03573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P6V6"/>
    <dbReference type="STRING" id="796604.A0A2X0P6V6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY77176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="547" mass="61092" checksum="10A75F2A8F560017" modified="2018-09-12" version="1">MTLSSPSRAWDGRPTDRTPLGPESLEWIGLPFDPSGDTELAYANLIERLEATLEGVQHRWLTHHTRAFYVNRYAIPKILHFLAADIPPPEVVKKLDDMLVDFVRGGKGRTSYGRDIVFTAKLKGGLGVIRMQDVVDAVAARIWDVLLGGSGAIWQGLARAALQRAQSDPDLATDLWPHPSTPIPSDLHPRWRAALGVPKQQDAQVNPRTLTTANLLALPTLLGSLHTPIRGRQTIDAVHIPDYLRLQGYPKVADLYRRELYAGGGFHLWTPPADVLGDNSEYDRRGLPQRLAIAAWYRFTVDRHKNTPLAVAVAAGRLNVPPRIGTSAPLEAILPKPVARFAMEQRLPDPVLPQQASQYKLLNMARPYTIRRIRRVLNAKAFTNTLGLKGPPQPGDLRSFWKAVNSKALTAREREIWFGLILRFTPMRKLQHQQNHDIPPACLVCEAPIAARGVLCDALRCDTIEVAQYTTLQRLFGLPKLKVKLSEQEGAGRTIEIFTGMVLEMISSGRWRMQKHGTRMESVERKRVVLEERMKLRAGGARGGRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PC30</accession>
    <name>A0A2X0PC30_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C031g10986 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C031g10986</name>
        <name evidence="2" type="ORF">BQ5605_C031G10986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000068">
        <property type="protein sequence ID" value="SGZ07004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PC30"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ07004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="259" mass="28971" checksum="49D21E8A4A46F114" modified="2018-09-12" version="1">MGDGNFVVHYFHPSSDCDVAYHSKVIPRSHFRGFKGKLPGEACVRWHYCQCVLCQKAADVNTMAGPDDRASTPPPSSTSTQSQNIDVSAIGSITLTREQYEELVRYQRTRDEEAPTPRHLLPPEAPAAFPEDSKLKGDNYVDWDITMSLTVDREVCAYLRRGTIDPTWTPTVRSRWQDYALHVLARSLTPATKATIGPVVQRGGSAHDCWLALTARYAPSDAQGHSSLIMNYFGMPQCPSTWKGFIDWSNRALVLINRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PCL5</accession>
    <name>A0A2X0PCL5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C102g13151 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C102g13151</name>
        <name evidence="25" type="ORF">BQ5605_C102G13151</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000073">
        <property type="protein sequence ID" value="SGZ10723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="922"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1203"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="1258"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="1295"/>
            <end position="1306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGZ10723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1813" mass="198439" checksum="EF7A5EE80F146054" modified="2018-09-12" version="1">MDDTSPPLATGVHPTFPADQLAALTSLLSGLTAAASGTVTTTTSSSTTRPAFPKHARLDGPKTFANWTRQLRLCLADDIRSYVLDGIVPVDWTPSQRSARELLANSIDSAEVSAVLDAIPTADLTAPKIYSTLKLRYAPDDATRTLELFSRLWSFRPMPGTVGEFDGWIMEFKAIAQEIIDTKTTINDVLATLLLAIAHPSLESFKASFTDEQRTQRSLPAIDSLADHMRVQLRSTNVPSTQSALLASSSSRPTRPKCLACHSPSHRVAECPVRAKHPPPGPCRSCKQNHWSFDCKKALENDKKADTANSTANSQHHVGCIATGFLARRRQLRTNSFVVDSGATSHMVSDKSLFTTYRHIAPTKIGGIAGGINTIRTGNIAFVAASGHPITLTGVLHTPGLFVNLLSVSRLCDTDDVRVAFTKHGIDIDKNGHNIAEGTRLDEGLYLLDADHSKCQHLALLSRSQSSVPLLTLHRCLGHLAPSSIQKMVAAGLLEGLGAGYSSLPLWAWSLHLGQVRAPDFGWADLGPAKWPHSGFSPAQATSWSGLPWLLAQPSYQCGHLRARPSLYFFTLRNMSDAGASAPEAKLREPTPDAPPLRPPTHFAAFATTELLRNLSGYRDWVLAIRSRLPSGVVRYLNTGVPLESWPASYVPLWDHYACSSICASVDSQTVLPGLSPYLDESLAAPKVWQALRVRYGTVSAVDLLPVIQRLFSSDPVPVTPDLFLQFRDSFENDARLLQDSQVTVNALLASHLLARLPSSFDAWRTTFVADQGNSTAMPSATEIFTRLYRDVKARPVDTPVAAVATPARHGCSRPCPNPSCRKLHWLRECPDTAWAAAYRARRTAEKKASQPVASPTPCTPKALLAVPDNVSLLTLHRRLAHLPVAQIKNIVQSGLVTGVDWVYKDQELRDFYCNACLASKAHALPFARSKSIASGRLDLLHVDVAQMPRPTFGGHRYMLVIIDDFSRKHWCILLALKSDVFPRLRDWILEVENATGNKVKTIRSDNGGEFTLRNFVDFCASKGIRRELTIPYTPQQNGRAERSNRTIKEGILALLYSSGADSRLWGEAALYYVDCKNLMPHAGIGGEIPDTRWHGFAPDISTLRAFGCRAWHHLPSAKRTDLDPKAVPLLFVGFDQHAKAFRLFEPSTRRIQLSRNVVFRESEFPALRPATDVRAEPIPLPVTVDAYPDQVDPLEPSLVASPRSLAPRAEPPRPVPAAPDQGPRRPAPAREVPDQDSLAPPAPDQGSPARELPDPESPASSASDQGSSDSAISTPCPSPRPVASRALPAPPSPARSDSPDPIDLLPRPRDVASLCQAQEFPDDVDDALHSPSAVAYLASGAAALIETSPADPAELIAPARDPPHWRAAMATPQADEWRLAARDEFDSLLRDFSAFTPIDESLVPADAKVLGSRFVFRTKRDQHGQVKSYKGRLVARAYLHGKLDAPLYIRVPDGIYMPGKVLQLHRSLYGLRQAGRIWNDEIDSALSALGYVATESDHCVYVRTTGDVHHYIALYVDDLLMISPSLPEIERTLQGLEQRYGVKRLGEAEYVLGIQIRRSPDGSISLSQEQYLKDVLARFGMSDAHPVATPMQPDLRLEVELQPTPFPDRTRYLQAIGSLMYASTGTRPDLAYTVGYLARFSHSPSAAAWGAVKHAFRYLAGTLSHGLRYARGNPAPLLGYSDCNWGACVLSSKSTMGYTFVYAGAAYLALSHAGKEAIFLRQLFGELGLSSSKPVLIYGDNQGANALTKNPVFHARTRHIRLREHFVRDMVSMGDIVVQYINTGEMTADIFTKALSRDLFARHRGRLGICAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PD48</accession>
    <name>A0A2X0PD48_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C029g10604 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C029g10604</name>
        <name evidence="1" type="ORF">BQ5605_C029G10604</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ14588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PD48"/>
    <dbReference type="STRING" id="796604.A0A2X0PD48"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ14588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="178" mass="19234" checksum="9ACEF9143BF148D8" modified="2018-09-12" version="1">MVYSDASFADDPESRRSVGAYASMLAGGVISWQSKQQSMIATSTTKAKILSASSATREAIWLRRLAGDVGIPQAQPTIIQEDNAACIQIAKDPVDHMRTKHFDIAHLFVRERVASGEVELEYCPTHVNAADIMTKPLGFQRFDQLCALLGMVSLVSLTGGSSCRGVPLSPCCNNWESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PE21</accession>
    <name>A0A2X0PE21_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C008g05008 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C008g05008</name>
        <name evidence="6" type="ORF">BQ5605_C008G05008</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY78991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PE21"/>
    <dbReference type="STRING" id="796604.A0A2X0PE21"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF119">
        <property type="entry name" value="NUCLEAR RNA-BINDING PROTEIN SART-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="294"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="398"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="158"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="368"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="455"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="212"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="237"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="492"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="542"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY78991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="565" mass="57663" checksum="DD6B8CD93C3A0C9C" modified="2018-09-12" version="1">MGKSTTPKTSKSASKIEKADSSKKTKSSTTAAASKKDSKKAVVAAPAVSAKVSKKASKKQPEPEPESSSSSSSESEDSDGDSSSSEEEAAPAVEKAKKGAAKVVAAVAPAKKNDSSSSESDSDDSSDDEEAAHCVVVSGYLHCIPVKAVKNAAKKVVKTAVSAKKAVANGAAKVAEVVAEETSSSEDDSSSEDEAPKAKSNGKAAATKATEESDDSSESADDSDDEEKPAATKADSDSSDDSDDGDDEEEEKASAVASKKRAADSTEAPAKKAKTADAPAPAAEASNDGEIVSSTVYVGGLSWNVDNEWLKSEFEVCGEVVSARVVTDRESGRSRGFGYVEFVKAESAQKALEMAGNEIDGRSIKVDLSQPRPNREQGAFGDKPKKTFNDTLSGPPTTTLFVGNLPFSCSEDSVWSVFADFGDVSSVRLPMDAESGRPKGFGYVEFSSLDGAEAAVKKGGPTADGEGVQVDGRTVRLDYSQPRGERSDRGGGGRGGGRGGFGGDRGGRGGRGGGRGGFGGDRGGRGGGRGGGRGGRQGDSGWGARAGSARTGGAASFEGKKMKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PEL9</accession>
    <name>A0A2X0PEL9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C022g09512 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C022g09512</name>
        <name evidence="2" type="ORF">BQ5605_C022G09512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PEL9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ22637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="75" mass="8095" checksum="09E6DF4A31C903A4" modified="2018-09-12" version="1">MVKLSLSPFVAPDAEPLLDPLLSPVGSCGPSDPKLIQLVSLPILFLIVVISVITMEFRRVVVATFHCSFSSNIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PET0</accession>
    <name>A0A2X0PET0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Store-operated calcium entry-associated regulatory factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Transmembrane protein 66</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BQ5605_C009g05500</name>
        <name evidence="16" type="ORF">BQ5605_C009G05500</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SARAF family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY81466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PET0"/>
    <dbReference type="STRING" id="796604.A0A2X0PET0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006816">
        <property type="term" value="P:calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001256">
        <property type="term" value="P:regulation of store-operated calcium entry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009567">
        <property type="entry name" value="SARAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929:SF0">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06682">
        <property type="entry name" value="SARAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="161"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="255"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="162"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SGY81466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="305" mass="31905" checksum="05F4666BE76BC32F" modified="2018-09-12" version="1">MTRSQRIKMTSLKALTLHSGQSTNYRRTSPVPQLTCLGKECRRYEPDVVQCTAVGEDGAGGLEWSCTAELPSGVRFGTVEVGCEGWEGPDDPYILRGSCGLTYELVRTSPALENGYGYTNPLAQYGSKSFYDAFFNIAFTAVTLFVLYRLFMSWYNRRPATRGGGAGTRSNRGGWGGGGGWWPGGGGGGGGGGGAGSGPPPPYSAKPDPATTTSQGWRPGFWSGIAAGALGAAAMNQRGGARSRFDEQRDFERYRDGGWDRGVGGSGSWGFGGGGGGGGGLRSRDSGSEMGSMRASTGFGGTRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PFE0</accession>
    <name>A0A2X0PFE0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C009g05770 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C009g05770</name>
        <name evidence="3" type="ORF">BQ5605_C009G05770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY85706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PFE0"/>
    <dbReference type="STRING" id="796604.A0A2X0PFE0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026907">
        <property type="entry name" value="GCIP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049317">
        <property type="entry name" value="GCIP-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492">
        <property type="entry name" value="CYCLIN D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492:SF1">
        <property type="entry name" value="CYCLIN-D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13324">
        <property type="entry name" value="GCIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-D1-binding protein 1-like N-terminal" evidence="2">
        <location>
            <begin position="149"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY85706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="413" mass="44871" checksum="AD87F700AF15CBDD" modified="2018-09-12" version="1">MTSSSKPQPQPKAPTSPIASTSSCSSSTSNASTSIPQIIQATLAQCQIILGVVSAQLEPSESTYSNTKGTSTPTHTTPSFTLLKAIRSDHLSLAQQIHSAVTSIALGFKPPISTGNGLESVFEQLRAVVAKVEFGVGELGKFGRGAGRRRRGGGCLERELRLSTQDLIEVTQAFLNTSLQVYNTSTAQTPSTQESKLRDQLLLHTSLVWAAVERSKLISENELRALNTRWKGVVEVLEDCLEEVKGLENAQMGQDGEAEDSERDEDDYRTSHPLDEQEKKTAKACLMLLRIGNLIVKRVIGVTGLAAGKDAEEEEEGKGFHSEAFQDKADEQIEAISEAADELASYLEPPHEMDELGEAVGEFVAQVEALIECVLEACWEGEGDGEDKELLWFNMGKVQLRGAEKKVRELLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PH20</accession>
    <name>A0A2X0PH20_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C054g12624 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C054g12624</name>
        <name evidence="3" type="ORF">BQ5605_C054G12624</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000093">
        <property type="protein sequence ID" value="SGZ29348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0PH20"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1259"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="641"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="703"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1792"/>
            <end position="1817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ29348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2036" mass="225857" checksum="E029A18C9964D444" modified="2018-09-12" version="1">MQTGDPGSAPGARAPPPPASAPTSLPIAGTKETQATQVAGRTATYAAATNSSVVSNETPAQQQDRLARLQALPGILAAIQAVPGNRADRFVQAIFATPDFPSTVATALKFSALNATRNIINPFANALEVSLSHKSTGRASATDKGELVACVRTLLSPNTPICFDTGVPLSGDLEAFMPRITGLQHSSTFRTGVLHHRITVGFVSAEARDAALASAPMLVWNSANAHFAKAHPFHRNMLEMRINVGVVRPPSKEQIVAAFQSIVQQLSTKGHSCQLVQVLRVIHVDTAKAYAHTVGDFSAFIHFDDASLFQHPTTTLKEILPSRMDLPTRGLDVTAVRHDYEKEAPCARCHFAGHVERCPLMQAANRKEAEDLARHAVMRGAGMVGGGEQTGVGRAATTTTNNIRPTANNNNTSEVVAPSRALGTDQLESRNRFAGLEVEGGQEDDVEEEDAGKEGEEKEQVEEGDEDTGAKADDEDSDSDGNAGAGIDKAGGDNKDDDKDEQDDSSEGSERRGDDVMKDGAEEDEEMETEVEEEVEQEQGVQDDSIMIIDDGQTTITTVSRESTPRSPSWPPLSPETLAKSLREGAEWDRANAEAAARVQAENEAIINAQLDAQEPLVRHQFAEWGQEDGQLRFINIRGTGSRSNKKMKRSQTVADLSDPSDDPVDVKRVLNRVKGRAGKEVAGQGKRVTRSMSAAAAMQVEGAKAKAEKGKGVEEEKRWSDHEPEDDILPEFPLFEDNITAKSTWNVRRCMGIPEKRRDIYTYLSTFKASAILLQEHFIKPELWQCIKDEYEGKAFISKHCLTLIPADSPLIDAEILRTHSALDGRILVTSFRLRGDIRILEINNIYAPVDTKQRLTFFDKLHFHRTQSTHLRLLGGDLNDCPLPAIDRRNQGRHGHHWPILIGKLDSPYTDCIRFKHPLTPSFTRPNIVRKRPKSFSRLDYFLLQRTHQKRLVQASTIYDHPKDLSDHRPVSIVLVLSDERGDAAQPNNSLPTTSNQLHRINAATFKTAAFQGMLEGWLEGASGEEPVGELEVVLGNCEKEGRELARREHRERVERMAVLVGRVQDLEALPVMGDEETAEWTRTTEELRRAVNERARQLRIRAHVPEIATEERLSRPVHAKLAARSSDSKITALRLPNGELTHDIDVALDHTQAHFQRLYNLEPRDRDHVERLRDDFLAPIRSARTCDDPSSDPLFLRRLSEAHIELLQQPITEDEVVAAIATTHPGRSPGPSGVPYELYHTAPRAWAKALSRAFNAMTERGSLSPRQGQGLVRLLFKHHKIGADRAELSSYRPITLRECDYKLFTKVYVARLNHVLPDLLPPQQHGFVKGRRSADASFHLRLLIEELGARGTEFPDAALLSLDQSSAYDLVEHEWIFAIFDALGAPATFQRVLRMLYSGDSTTARYIINGFLTPPVRLTCGLGQGDPASSSVWDVVFQPFLDALHRRGIALNLSLPTIHPYPQSRAITSLAFADDVVVAVAGSESLTLLDDLALDWRLATNGRLNTDKTVVLPIGCRWEAGDRPLVVKAEGESLEWIGLSFDPTGNTELANVNLVARLEAVLDSARDRGLTHHTRAFYVNRYAIPKILHILSADIPPLEVEVVYGKDVVFTPRFKGGLGVMRMQDVVDSVAARVWDVLLGGSDAIWQGLARAAIVRAHPAPDFDLATDAWPCDYTPIRTDLHPRWQAVLKVPSTHNAQVKPRTLTLANLLALPIKLHTLHYLPGAPAVSRSPYDADYAAFAITPSEYDQRGRPQREHIVAWYRHAINRLRFTPIAQPVAAVRINGPPRVRPRSEVRPTTPLESILPHPIDPPQRLPRPALPDQSTQYNLLSMDRPYTIRRVRRVLNAKAFTDTIGFRDSLQPDDLKGFWKGVNSKALTAREREVWFKLVRNFTPTRSLQFHQKHDDSPACLVCGAPKDDREHYFFDCVDSGNVWIAARSVLCDALGLDTIDNTHYTAVQRMFGLPKLKASLRDQEGAGRTIEIFTGLVLEMISSGRWGMQKWGTRMEGVGRRRIILEERLKLRAGGAWGRRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PHB6</accession>
    <name>A0A2X0PHB6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BQ5605_C035g11371 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C035g11371</name>
        <name evidence="12" type="ORF">BQ5605_C035G11371</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIAS family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000064">
        <property type="protein sequence ID" value="SGY96952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PHB6"/>
    <dbReference type="STRING" id="796604.A0A2X0PHB6"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.780">
        <property type="entry name" value="PINIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023321">
        <property type="entry name" value="PINIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038654">
        <property type="entry name" value="PINIT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF4">
        <property type="entry name" value="TONALLI, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14324">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02891">
        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51466">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PINIT" evidence="11">
        <location>
            <begin position="160"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="SP-RING-type" evidence="10">
        <location>
            <begin position="355"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="445"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="488"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="559"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="605"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="636"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="654"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="674"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="693"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY96952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="737" mass="79254" checksum="DF2EF8868B5C8EA7" modified="2018-09-12" version="1">MDSQEVRLNITQDVIQDLRSLTVDNLKRVIRLFNDKGLSIHGHLRLSGTKADLFSRLSHVVRTIYTTQRASFPSLVNIVSDVLRNIGSSPASARYAGYNSQYGAAPAYRPPAAQDYSASTSNGASHQNQALAYNRPDSYHLNGVPRPGYAAANLHGHVAAQASTSNPVVELIKFRPSPFYRIDKALSPVTHMPRAGQGDRKSVVINFVIPEPQRALILASKAANAKPYQVRLYCTTEDHYNPSRPTNLQLAAPIEFPGVCEIKLNHTNIVANTKGIKKQAGTAPPVDLMKGGALSYQSAGGVNRLEIVYINTDKRHSVVVNLVEVTSIEDLVTRVRGGTSRSKEDVVKKIVEMNSDPDVEASSFGLSLKDPLTMARISLPIRSSVCNHIACFDAKVFFMINEQTPSWTCPICSKELRVEDLFVDGYLQDVLRGCSSDVDQVSVEPDGSWHLIETEEHSTRQSRAGSVRAKADPDGPNGNDAKGKGRADTSSLSMTLEDSSDDEGGGGRGGARKAAPMNGAMNGKASGSGSGTGTSTPRGGKRMEAIDLTLSSDGEDAPAAPPSRAPPPPTTVTNGLPASRAPLSLPIRPGSATPAYSVPPPRPPSSNSSSGGANGSSSIGHQHPHHGTARPPFGGPSSSFDRSTAPTPSSRLINPLPHSSSSNSNPLKSTSTSHVPNFSTSAQSVLSRPMPWDVERERERERQRKRDAAAEVALEVARKRLRYEEHRYEDDYADEFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PHQ0</accession>
    <name>A0A2X0PHQ0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C032g11108 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C032g11108</name>
        <name evidence="2" type="ORF">BQ5605_C032G11108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000067">
        <property type="protein sequence ID" value="SGZ05107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PHQ0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ05107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="496" mass="54217" checksum="60D8D2851D1FDC9B" modified="2018-09-12" version="1">MGPRTRLPATFTATGDPLKDSTNLVQTRDRKPRDVAAAPVNKSSGASGSGVSPHTAKPLTTSTTAASRVVVSPGPADDPHSGPTHLHLPKALHESQVCAATHHCRRDSLTSDERHDHPASTTAALATLDSHSSTTLNQRQNFTTLKSESKAKVKDLVILTDRDDDDDDDVGEPRKRRRTATSWAVSDSEEAEDNTFQVMHSKPQYSTPYFDGPSNPPNAASGQDGPSVSAATIGAQLERVEIQLARLVDVLTAPSLDNIKSDVGSAKIFVSTPFLCKHHGAAPCSRDVKHRAFYKVLMRHLSSALMQGRSELEDHIKRAQGDSLLLGKTMKSWYKNLEVTITDEHVCWWRVLWQAVKQPDRKATVEADLTGNESHKTANVPGSRSNSFAEKVNHVSSTLAEIAVDAYLEGEYKHGLEFDHQSFLTDQLAPVMPRHDGIKTSQPGRRQNSMQIFCLEVVENPDHEISFASLVEGCLQADQEAAQNPKSKKKKKKTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PID4</accession>
    <name>A0A2X0PID4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C044g12155 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C044g12155</name>
        <name evidence="2" type="ORF">BQ5605_C044G12155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000114">
        <property type="protein sequence ID" value="SGZ31353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PID4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ31353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="201" mass="22394" checksum="CED9D12A94B67129" modified="2018-09-12" version="1">MAHGKKAQGVPPPVSNQQDQTAKSSLDEEPVLTKPKGLKLITPKLTNGTLTLASIRAFLTDMDNLFIRHGVSDMGFKIMLIQNHVEHDHLKDWLVSSTEDHTWDKFKVAMKQIRDSKQRNMDYPTRALGLCALQLQLGQAALGDAEFIKILLFNMDTQLSVVLRQNDLLVNTGLHQDNLDYIAASKAGLAKPEAVSYEAFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-11-27" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PIG9</accession>
    <name>A0A2X0PIG9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C045g12197 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C045g12197</name>
        <name evidence="2" type="ORF">BQ5605_C045G12197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000115">
        <property type="protein sequence ID" value="SGZ31532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PIG9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="1">
        <location>
            <begin position="154"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ31532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="240" mass="26463" checksum="F7075525E3D79A58" modified="2018-09-12" version="1">MSSHGASGPRLPPPAKRIGYTGQPLDARKLRNINKWPAGVLKKGRLGFYPTQHYLSYKDGHLANACTVLPHLLLKSRVDMLRAHEISVMTEQARALLHNTLTQDDLKKVLATQALVQSVDDDDEMQEASAASWHVRILGKEGEQCLRTKALTPFLLDSGAMRHMTTQLDLLHDYCPSLADRRVRVTGAFGSGGFTSCTGKLRFPTGGKDMVLRNILYVPGLEAELVSLNCLIEDDYNVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PJH4</accession>
    <name>A0A2X0PJH4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C069g12861 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C069g12861</name>
        <name evidence="3" type="ORF">BQ5605_C069G12861</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NPR2 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000131">
        <property type="protein sequence ID" value="SGZ35087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PJH4"/>
    <dbReference type="STRING" id="796604.A0A2X0PJH4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009348">
        <property type="entry name" value="NPR2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991:SF10">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991">
        <property type="entry name" value="NITROGEN PERMEASE REGULATOR 2/TUMOR SUPPRESSOR CANDIDATE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06218">
        <property type="entry name" value="NPR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="472"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="516"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="613"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="486"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="559"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="621"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="636"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ35087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="661" mass="73449" checksum="CBED9D9409866B26" modified="2018-09-12" version="1">MPLLMKERLQGQSGEYLPRLIAVMYCVFDPIAGPTVVEQVPEGSVATALSTFPKSAPISSSRPRAGAETSMERSALLNRQRSTTRARSSTQGGTATDAVVRSTSKQRLTATPVLFDFSPIREFVIPKPELCGHLITKATRTCKILGFPIRIVDEEKYNSTRSIYNRNAFIFNVCFIFERDAELSVFEPVVRKVARTLRILEESSSLLSDPPPHFSMGNLLEQLYMDLNNFSEASIRIGDFELELFLSPFYANPKPIKNSDVPLAVCALEQMKHPSWDVTLYKICSFINGINHVKGIAELAQVDLHLARLSIQHLVFYGAVIIVDLFQYTNSYATLPLIADVVHTMDEAEEDEGIQNLDSECQAYVYTGAMINPMLASATPPTATTNLEGSSVGSLPNYPSPSSAPVPFANLLGYYAQLRPGVTVTQWCEKLGLDGLPIDVRRLVQFGCIKGFLRRVYTYPVWLDHPKFLKHRNRGRHGDDVEGDEGTTSFFLPTPSNETPLHSAISTLSRMETNDASLLDPPSSGILSRPNRSKTTFHPSATPAKTRAEVRQSARKGRSSGSPATTNVPPISRFPPSLPMMMDGTYHTDEICVKYSISFKQLEVIFRTLGKGRSGKYEGSLGEEERGEEEEDDDDDLRRRRDDESLHSGSNYGDRLVLLYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PLG6</accession>
    <name>A0A2X0PLG6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C024g09931 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C024g09931</name>
        <name evidence="3" type="ORF">BQ5605_C024G09931</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ26520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PLG6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="30"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ26520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="368" mass="40411" checksum="06D1B4DC3306EF1E" modified="2018-09-12" version="1">MVPPQRKSNPNQAVNSKKRKRIARTSRETSCESCRRRKLKCTSARPACSICVRSAQLHGLDPIDAICHYSVESIHTIDYDRTVDQMLKKGCCVVDRELKQQLAGAISQLTDKQRRGELDIVLRRKRKALDEPLSSSELKESCASETPLKHITASRRSTRFFARPDLGSIKSSEQVRTTCKSSPSPPQDPPPPVSSPGSSSPLSSLVGDTPLHTEERHPKGHKEASQGSSEEPNLPEGKIEPADHLSTSPMHALVPTPAPLSPSSVASPSPSKRELGQPPTVGSVIATLDSTRVKRLEDTICKIEDSLARTLTTEFPSPGGSSETKAVNDLDRLWAPPLLLSEDFWLPGPLRKEELWGWRVIEAYGMTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PPS7</accession>
    <name>A0A2X0PPS7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C064g12787 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C064g12787</name>
        <name evidence="6" type="ORF">BQ5605_C064G12787</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c oxidase subunit 6B family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000132">
        <property type="protein sequence ID" value="SGZ35159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PPS7"/>
    <dbReference type="STRING" id="796604.A0A2X0PPS7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048281">
        <property type="entry name" value="COA6_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47677">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47677:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGZ35159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="113" mass="12587" checksum="961F7E7A8144B928" modified="2018-09-12" version="1">MWPFSSSSSTSTASTSTSALPAGSPSSIPDRSARQACWDHRDAYFGCLEKNGVIVPGAEKEKGLCQNEREGYEARCAQSWVDYFNKRRLLQLRQDRMNAQQAEQLKAQGGIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PQ53</accession>
    <name>A0A2X0PQ53_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">BQ5605_C043g12118</name>
        <name evidence="14" type="synonym">BQ5605_C006g04350</name>
        <name evidence="14" type="ORF">BQ5605_C006G04350</name>
        <name evidence="15" type="ORF">BQ5605_C043G12118</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY58214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000117">
        <property type="protein sequence ID" value="SGZ32214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PQ53"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000007">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="12">
        <location>
            <begin position="363"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="13">
        <location>
            <begin position="905"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="11">
        <location>
            <begin position="1217"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="10"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGY58214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SGZ32214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1269" mass="141962" checksum="94F506DEBE7EDA09" modified="2018-09-12" version="1">MPTPTAPSHSPTYSRPAAASAAPHVATAATSHSPITGGPRPVARLTVDERAYLDQNHGCYRCRTLNADHISRNCPRYLSPMGASATPLTPTLTAPAPRPGPRMVAAIRTFQETGDSTVFAGLSSDSENDNDPSYAPHPFPPLPVSLAGAHGTLLASALVDSGLPQTFLSEELVQRLGLERRALEQHSKYTLAMQDQVPTVFTCTHFVRVPLELANGLWAAGPTYAEVAPLGKDLAIILGGNFIYRHKMELGLFPQPHLTCKANPIHAIDLLALSSQPCAAARVAAIAPVSDDEEQLRLAALDHRLRAEFADRFPADIPPVHSYQSPVRHRIELDTPSTVVNLRGYPLPKKYCEAWYLLLQEHLAAGRLRPSRSAYSSPSFIIPKKGCDVDPTIAPRWVNDYRELNKHTIKDRTPLPLPDDILSTCSNAQFWAKIDMTNSFFQTKMAEEDIHKTAVSTPWGLYEWTVMPMGLCNAPATHQRRVNEALQGLLGTICFVYLDDITIFADTLEEHEARVRQVLDALRRAELYCSPTKTNLATAECSFLGHIINRAGVHADPKKVQRIEDWSLPKTAKELRGFLGLVQYLRKFIPGLAEHTAALTPLTRQGLSSIATLWTPNEVRHFKAIKAIVTSLDCLRPPDHSANAAPFWVMTDASNQGIGGVLLQGQEWKVARPIAYWSRQYIPAERNYPTHEQELLAIVEALKEWRIDLLGGHFHILTDHSTLEHFQTQRTVLSCRQARWLDTLAEFDYDLRYLPGEDNIVADAMSRYSFTDPLPTLVAAVSHVKFSDAVKQQILDAYETDPFCQQAMSNIGSVTSDFKIVDALLYLRGRLIIPSLAPLRESILHDAHDAQGHLGDMKTYRTVQQAYFWPNMSRDVKHYVQQCDSCQRTKARTTRIAGKLHSLPVPTRPMADIAIDFVGPLPANKGFDRVLTITDRLSGYVRLLPAREADTAAEVAARFHEGWHRLFGLPQSIVSDRDKLFTSKFWTALHKRLNIKLQLSSAFHPETDGRSEKTNKTAFQILRALVNKEQSNWAECLAVCEYAINSSLNVATGKTPFELVLGYMPSLAPLARVDGDDDLPSVEELLALRFQACEDARDQLAISKVRQAAQSNKKRQDEPSWAVGDLVLLDSSDRQKRLHTRKRRAAKLMDRFDGPYRIVKAQPEISSYTLQLNRDDAAVPFFHTGKLKTYRKNDTALFPNREPARLGPVDVGGEPEYIIEDIVDERIRAGKQQYLVSWLLWPSDSNSWEPAEALEDTEALDRWERRNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-10-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LND6</accession>
    <name>A0A2X0LND6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C093g13070 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C093g13070</name>
        <name evidence="8" type="ORF">BQ5605_C093G13070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000005">
        <property type="protein sequence ID" value="SGY11568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LND6"/>
    <dbReference type="STRING" id="796604.A0A2X0LND6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
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    </evidence>
    <sequence length="544" mass="62997" checksum="7537AC4BA39C6734" modified="2018-09-12" version="1">MAYTVINLSRPSHPNYHTFAHRLSNGWILGWKIDNSDHQWYKFRTNLPLLTGVMLIWLALSTTYNLIARLATPSPTDSPSPTPASEARSHPTSSTSLPPRVPFIIFFALILLFGLHGMSLPKMLIILWFNYRIARLATSPTLSKSVPWLTWAFNLAILFSNEVNEGYQWANLSPSLQQWLISRVMIQDQAKWAQGILPRWHINWNITMLRLISFNMDYYWAANVASGEAQTIRSTEEEKLELLTQKLSAPPLNDRTRVTKSHPLSDYSFMTYLAYAFYPPLYLAGPILTYNSKMLLGYIVRFVACLLTMELVLHSMYVVAIKDEARSGAWSGESPFELSMIGFWNLIVVWLKLLIPWRFFRLWALLDSIDPPENMVRCMANNYSTLGFWRSWHRSYNLWCIRYLYVPIGGAKRALIATLTVFTFVALWHDLSLKLLTWGWVITVFVLPEMVGMKVLSAQKYAHHRWYRHVCALGGVLNVHMMMTANLIGFAIGTEGMKYMWSRMIESWQGVRFITLASACLFVAVQVMFEYREEEKRRGIRRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LQN2</accession>
    <name>A0A2X0LQN2_9BASI</name>
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        <submittedName>
            <fullName evidence="1">BQ5605_C010g06170 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C010g06170</name>
        <name evidence="1" type="ORF">BQ5605_C010G06170</name>
    </gene>
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        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
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                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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            <dbReference type="EMBL" id="SGY14398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="165" mass="18257" checksum="EA68696658C0A382" modified="2018-09-12" version="1">MGQIAFACNQRHNAMQHRNGLTTLACGANDRLTTFLHDCGLTTSRWATLQAAASLTKANSTKPKEIGSNKYFHQLDRRTELLHGTFGYAHIQNGDIAGAYNLRAYSAHQASLPQVISSISSQLPNPTRHLQPGSKFRYIERLLDWFLILASVFAVLNAHHPLSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LW08</accession>
    <name>A0A2X0LW08_9BASI</name>
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        <submittedName>
            <fullName evidence="2">BQ5605_C012g06734 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C012g06734</name>
        <name evidence="2" type="ORF">BQ5605_C012G06734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
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                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16015.1"/>
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            <end position="59"/>
        </location>
    </feature>
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            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="SGY16015.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="144" mass="15351" checksum="E3839F64CFC6B3DB" modified="2018-09-12" version="1">MAEWLGKVFPVGVATPERAATGRRGWSGGGAEGGRRGGGGGRAGRGAGGPGQLGPPKAQPEAHFFFFDILRTQNPENRRGALQKIDILGRNTRFAPEAHPLTNMNMTIAELLAFDVAPADASLHIELSKDEHTQYSTLSSTRCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LWB5</accession>
    <name>A0A2X0LWB5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C012g07023 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C012g07023</name>
        <name evidence="10" type="ORF">BQ5605_C012G07023</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16906.1"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Chromosome 8, whole genome shotgun sequence"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067:SF7">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE DMA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17123">
        <property type="entry name" value="zf-RING_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FHA" evidence="8">
        <location>
            <begin position="319"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="476"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="15"/>
            <end position="92"/>
        </location>
    </feature>
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        <location>
            <begin position="128"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="196"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="611"/>
            <end position="643"/>
        </location>
    </feature>
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        <location>
            <begin position="701"/>
            <end position="754"/>
        </location>
    </feature>
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            <begin position="15"/>
            <end position="39"/>
        </location>
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        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
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            <begin position="239"/>
            <end position="269"/>
        </location>
    </feature>
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            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="707"/>
            <end position="719"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY16906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="754" mass="78005" checksum="88F7B9F213CD2315" modified="2018-09-12" version="1">MAAPGHVDAANAAVALAKSASSSSAAAPSTEPRASAAPAVDDIPAEPLLSRPHSPAAMQPATEVNEAASPSDAHRARPASSTRTSGGAPTIPLAAPMAASTMVPSSPSASSSSTNRFGLALGFMGRRPRGFTNPSMPGLGSVTRSPVGGGGSGSPSSELPPSSPGASERMGYGFPALRRSLSKRAAVAQANQAGAAALVSGSSEGARTRARRSSSQPQLPAAIEARDAVAQSHGRSRPRTATETDVLTTSSSSPGTVQPASRTVGSTVASAPRATAVASTPVPDNPAPTYRLRLVPHLETSRSLHFEAVDRELAPFTVLRVGRFTDRANHINTTDQLRITFKSKVVSRGHAEVWCDAKGKFFIKDTKSSSGTFLNHIRLSSPNTESRPYGIKDGDILQLGVDYQGGAEEIYRCVKMKVELNRGWQRGVNSFNTAALAQLRALGGGSALTDTPATVAKSSSTSTPPNIAVSSSVTDCCICLYPVTVCQALFIAPCSHVTHYKCIRPLVLQNYPGFSCPLCRTYADLEADVEIDPPEPDIAVPGLADLPAVVDEAPECDIADRSPPMNLSMSVHTELSAAQDGPSVTPDATTVPFGDVDMIPLESDSATSAPNAIITSSNKPTTDLSAVSVGTRPPGSNISEPLPIETAATSDNDAIYASLMNAATPPNSTFLSTLAERADSHFPRFRTTVASLDMALLPAPEAGPSGTVLQQGSTGSDTDAANGDDEGLNVTARKRQGAEENRSAGCRSLTQAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LX60</accession>
    <name>A0A2X0LX60_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C121g13297 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C121g13297</name>
        <name evidence="3" type="ORF">BQ5605_C121G13297</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000027">
        <property type="protein sequence ID" value="SGY27686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0LX60"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1160"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="621"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1722"/>
            <end position="1747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY27686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1966" mass="218098" checksum="2203E5BC9EFC6DA2" modified="2018-09-12" version="1">MQTGDPGSAPGARAPPPPASAPTSLPIAGTKETQATQVAGRTATYAAATNSSVVSNETPAQQQDRLARLQALPGILAAIQAVPGNRADRFVQAIFATPDFPSTVATALKFSALNATRNIINPFANALEGSSLRAYAPCSRPTRPICFDTGVPLSGDLEAFMPRITGLQHSSTFRTGVLHHRITVGFVSAEARDAALASAPMLVWNSANAHFAKAHPFHRNMLEMRINVGVVLRVIHVDTAKAYAHTVGDFSAFIHFDDASLFQHPTTTLKEILPSRMDLPTRGLDVTAVRHDYEKEAPKEAEDLARHAVMRGAGMVGGGEQTGVGRAATTTTNNIRPTANNNNTSEVVAPSRALGTDQLESRNRFAGLEVEGGQEDDVEEEDAGKEGEEKEQVEEGDEDTGAKADDEDSDSDGNAGAGIDKAGGDNKDDDKDEQDDSSEGSERRGDDVMKDGAEEDEEMETEVEEEVEQEQGVQDDSIMIIDDGQTTITTVSRESTPRSPSWPPLSPETLAKSLREGAEKRGDHQRPTRRRRNRSFATNLQSGVRKMDNCDSSTFVAPAPRSNKKMKRSQTVADLSDPSDDPVDVKRVLNRVKGRAGKEVAGQGKRVTRSMSAAAAMQVEGAKAKAEKGKGVEEEKRWSDHEPEDDILPEFPLFEDNITAKSTWNVRRCMGIPEKRRDIYTYLSTFKASAILLQEHFIKPELWQCIKDEYEGKAFISKHCLTLIPADSPLIDAEILRTHSALDGRILVTSFRLRGDIRILEINNFTHQSIQNNDSHSLTNYISTGRRAPTFDSSAAISTTARCRRSIGGTKVRHGHHWPILIGKLDSPYTDCIRFKHPLTPSFTRPNIRTHQKRLVQASTIYDHPKDLSDHRPVSIVLVLSDERGDAAQPNNSLPTTSNQLHRINAATFKTAAFQGMLEGWLEGASGEEPVGELEVVLGNCEKEGRELARREHRERVERMAVLVGRVQDLEALPVMGDEETAEWTRTTEELRRAVNERARQLRIRAHVPEIATEERLSRPGPRQARGTEFDSKITALRLPNGELTHDIDVALDHTQAHFQRLYNLEPRDRDHVERLRDDFLAPIRSARTCDDPSSDPLFLRRLSEAHIELLQQPITEDEVVAAIATTHPGRSPGPSGVPYELYHTAPRAWAKALSRAFNAMTERGSLSPRQGQGLVRLLFKHHKIGADRAELSSYRPITLRECDYKLFTKVYVARLNHVLPDLLPPQQHGFVKGRRSADASFHLRLLIEELGARGTEFPDAALLSLDQSSAYDLVEHEWIFAIFDALGAPATFQRVLRMLYSGDSTTARYIINGFLTPPVRLTCGLGQGDPASSSVWDVVFQPFLDALHRRGIALNLSLPTIHPYPQSRAITSLAFADDVVVAVAGSESLTLLDDLALDWRLATNGRLNTDKTVVLPIGCRWEAGDRPLVVKAEGESLEWIGLSFDPTGNTELANVNLVARLEAVLDSARDRGLTHHTRAFYVNRYAIPKILHILSADIPPLEVVKELDRILVDFVRGGKRRSCYGKDDVVDSVAARVWDVLLGGSDAIWQGLARAAIVRAHPAPDFDLATDAWPCDYTPIRTDLHPRWQAVLKVPSTHNAQVKPRTLTLANLLALPIKLHTLHYLPGAPAVSRSPYDADYAAFANYAKVADLFRRELYPGGGFHLWTPPTDVVVSNSEYDQRGRPQREHIVAWYRHAINRLRFTPIAQPVAAVRINGPPRVRPRSEVRPTTPLESILPHPIDPPQRLPRPALPDQSTQYNLLSMDRPYTIRRVRRVLNAKAFTDTIGFRDSLQPDDLKGFWKGVNSKALTAREREVWFKLVRNFTPTRSLQFHQKHDDSPACLVCGAPKDDREHYFFDCVDSGNVWIAARSVLCDALGLDTIDNTHYTAVQRMFGLPKLKASLRDQEGAGRTIEIFTGLVLEMISSGRWGMQKWGTRMEGVVRRRIILEERLKLRAGGAWGRRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LX77</accession>
    <name>A0A2X0LX77_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C012g07042 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C012g07042</name>
        <name evidence="2" type="ORF">BQ5605_C012G07042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LX77"/>
    <dbReference type="STRING" id="796604.A0A2X0LX77"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY16957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="344" mass="37391" checksum="813A416AB631BF27" modified="2018-09-12" version="1">MPRFLSHLAALVAPLPRVPTLVTKRFSSSLYVRLFGDAPLESLAASRSSPASASVPSVNDATLLSSNATRSTDRSFKLPSSPSHSPSGKRYASSLSVQAPGVASAPRLPSTLAGVRSDRRRAAFHINPIETSLRDQITATTPTTTSILTSFFAPASVPSSTARRPVISTPFIKHSRSAAAVAVTLTSPAASSIPFPRTPTRASRNTTVVLSAPPLRSPLARPRKTKTASRVALLPTIRDEIEQEEPEQPKREDLTATDPRFVDLRSLTRPRQKPRASRRKVDNGRWLTLLALENANIARKAAVAEAREKAKAVLEQDRRPILENDDEDDDTYFAQLPTWNDGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LXQ1</accession>
    <name>A0A2X0LXQ1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C002g01096 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C002g01096</name>
        <name evidence="1" type="ORF">BQ5605_C002G01096</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY29918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LXQ1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY29918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="86" mass="9652" checksum="76CCE01C99DE80D2" modified="2018-09-12" version="1">MSAHVRTLDYRSIHDDIVSFRCHFMCGPQPCRSLMCGHVSVKPVKCPHMAVCGPHLAQRSADPSGRTPSPPENLEQFKEETYLLLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LXW4</accession>
    <name>A0A2X0LXW4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C002g01166 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C002g01166</name>
        <name evidence="6" type="ORF">BQ5605_C002G01166</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY30580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LXW4"/>
    <dbReference type="STRING" id="796604.A0A2X0LXW4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043813">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043573">
        <property type="entry name" value="Fig4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738:SF5">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="5">
        <location>
            <begin position="381"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="122"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="244"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="521"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="964"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1121"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="990"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1001"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1015"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1121"/>
            <end position="1131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY30580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1179" mass="129582" checksum="815BF0979429B9A1" modified="2018-09-12" version="1">MVTAAGSSPSTSRLTSPVRSPTAASVRSTTVVQRELGPPRVPAQAAVAGADERLGRPLAFGEPGPEVTSSTSQVTEAQVGRVGQVEQAASHVPSAPPPAPTFAPTSALDPASIVSTSTSVIPATLHPPSATQADGSSEASSSRRERSKSSASRAPRIVPLPIRNGRSEPGGRLVLDKFAVYETNLVCRRGLLTGISCLGSGQKIYIIACNQSDSRYRVLKIDRATSSPSMTVAPIAFSSAPNPILTTNSTATTTSEDSSEPSAADPSKKGKAARMTEEAKEGLVITEDETIYSRDEIELLKETLSAGNAGGLRKVDGTFYGIVGFIRFTDPYYIVLIKRRQHVALIGGHYIYHCEEVVLRPITSSAVTTRSTEEARRIHAFQGVDLSKNFYFSYTYDVTHTLQHNLTRSGGPSLNVDGGGRNDPLTTYNDKWVWNRFLLTPAFAHLKQDSPWVLPLIHGFVDQAKLSVFGRTIYITLIARRSRHFAGARFLKRGANEQGYVANDVETEQIVSDALTTSFHSPSAATHQHPATGESHQNRRPNPRFTSFVQVRGSIPLFWSQESTNMSPKPPIECELTIVDPYFTAAALHFDDLLGRYGGPITILNLIKQKERTPRESKLLPEFKQCIDYLNQFLPDEHKIEYIAWDLAAANKRRDKDVIGVLEDIAEESLAKTKFFHTGPEPTWFKIHPDASHPMEYRSTPLLQSGVVRTNCIDCLDRTNAAQFVIAKAALGHQLHALGIIDYPRVPFESDAVNMIMEMFHDHGDTVALQYGGSHLVNTMETYRGIAQWTSHSRDIVNNLRRYYTNSFVDADKQAAIDVFLGIEAPVAHQPPLSYSQTKNRRSYRNWYTPEHFKASLTPSEAERRLKATVEDDDASGSANYWQAFYRPQLLTQFDKHFAVIMNSTSRYLKAAALISDGPDASPFVARHALNVAQHRSVRLHYFIDELWANPLHQLYDSLRLQNPSKLSRPRSGTRGAGVGGSRPASSLRSRIEAQRIDEASSTTGTTRTRNSSTQAQSHGQRSSSSLGVVAVPSHVAAVPSVVGPGGAVAPVTEALVHRLLEPRVEPIEAREYTSWVEQFQHLSLAQELSHKDARLYEEHAGLAGQPLSAVLTSSMGHDPRFEQWREDDRGGGGGGSDDRDELGSWMDNQGVRLRVDSANVLLYEDMVRRSRPVAMMAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LYC7</accession>
    <name>A0A2X0LYC7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C002g01263 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C002g01263</name>
        <name evidence="1" type="ORF">BQ5605_C002G01263</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY31817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LYC7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY31817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="56" mass="6243" checksum="2AAAB2282AE6AFBA" modified="2018-09-12" version="1">MGGGRTPESPARGGPQIWTFWDPENRLGSPQIWTFLAQNGSRLTSFLDIFLPPVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZ08</accession>
    <name>A0A2X0LZ08_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C017g08546 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C017g08546</name>
        <name evidence="1" type="ORF">BQ5605_C017G08546</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY20243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LZ08"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY20243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="69" mass="7513" checksum="16623976C770580A" modified="2018-09-12" version="1">MSLLSDLVHLRTIDHNSRISTSRVQQHQLQHGSPEGAFSGAPRGRILQAESACERAIPTSAPLVVRSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZW9</accession>
    <name>A0A2X0LZW9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C019g08855 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C019g08855</name>
        <name evidence="4" type="ORF">BQ5605_C019G08855</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY22776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LZW9"/>
    <dbReference type="STRING" id="796604.A0A2X0LZW9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005330">
        <property type="entry name" value="MHYT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35152">
        <property type="entry name" value="DOMAIN SIGNALLING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G11310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35152:SF1">
        <property type="entry name" value="DOMAIN SIGNALLING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G11310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03707">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="MHYT" evidence="3">
        <location>
            <begin position="67"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="MHYT" evidence="3">
        <location>
            <begin position="254"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="896"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="944"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="944"/>
            <end position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY22776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1020" mass="111184" checksum="CCDF362F6212F34C" modified="2018-09-12" version="1">MTSGATARPDYVQLETHYSGIYVFVAYVIAVVGAWTTLELLLRRTGGSAKWNAVLLVGAGVSFGSTATWGMHFVGNQAVTLHYPPPSTEPPRPLSYNVGYTLLSLVVACLSMVIAFSSIGLRLDGRRKNRDGSNVGQVDEEYEYVLGSPELELEVTKSKISRGDDKARSEPPERVTAGLLGGAKTAHPSDTTPKHGVSKLAHISLPGRTKGRCSRKQFNKNLDEEEDGGEFGVVPASVSILGVAKILGAGCICGGGIAAMHYVGQLAINSVPRVTNTPYIIFLSILIAMVAVSVGLFLLFVVLRPKLEHRWYKRAGIAMILAVATTLMHFGELGAIYSKSGLNFSIYLHQRIRISSVALLGTQYYAIQGSTSKPATTSRNLILALVSVVAPVCCLSLLVFAVIGQQRLLQRMAARQRIVVATAIWDGHGRLLVREADGLLPSSTLFPKVEKAKPTGVLEWLGLRNRLSLESSNKKLGRFDHAFVALLRASWAWKEQSLATVTRVDSEVGATHDARRGSTISSQADVHARDYGAREFVAQAASAPGRPSLPVDVETDDQDEGHYDLESQEGDFDDDAHERMRSAVLGFEVAGREIATELVGSPELSANGVLFDQILNTGHFEVSSRDSGDKFTVTQGQLLMLTRRIRSRAERDALLARGYTFVEPAAAARVTATAFAVPTDRVYDHFRDAYRFARFMSQRRYTRGRLYGAALVVQALPGEGLQLVVDEKQHHSLPMVELASLVRSSAERVWKQHTSLPLATLDGMLETVRQLQGRTLLELVQFTTPFTPESAQIHSLLVHMLRPFIDRVFSSECMDFLLPRLVVIPTLIPLTTHQGPIYSADGLTADAYLVCLKAVVPSAVNLANAPLNWIPYSLYKAQNDCIARYERQRRARLNLAARTTQHASSSTAGSGSASVSVGSPSLSGHINQGFSNVTTVLRKADVTNPARRESIHSHTSDYGDTTDFDEEAGEDVADEALEHRLLGLPTFNANFVEDLIRGGPVSNNLALPIEQLRQSSKRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZZ9</accession>
    <name>A0A2X0LZZ9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C016g08122 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C016g08122</name>
        <name evidence="2" type="ORF">BQ5605_C016G08122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY20679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LZZ9"/>
    <dbReference type="STRING" id="796604.A0A2X0LZZ9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY20679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="110" mass="12320" checksum="43186777C5DDE267" modified="2018-09-12" version="1">MQFLFGPVVPNAPAGTPPPHPSLPRQHPDSSSSSTFGERSTASTTSQKRRRKAPILAPKIPRGLFERAHSKKTKRSVSSADVQRYRTFDQTLYIQTLDYCDKNDIRPCAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M007</accession>
    <name>A0A2X0M007_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C003g01835 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C003g01835</name>
        <name evidence="9" type="ORF">BQ5605_C003G01835</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY37562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M007"/>
    <dbReference type="STRING" id="796604.A0A2X0M007"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07331">
        <property type="entry name" value="M48C_Oma1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051156">
        <property type="entry name" value="Mito/Outer_Membr_Metalloprot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726:SF1">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M48" evidence="8">
        <location>
            <begin position="254"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="71"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY37562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="457" mass="49975" checksum="3738CE67ED7CDA4C" modified="2018-09-12" version="1">MRSKIGNFGGFYLRASDWAFGGLDTVGHLHICKQQPQPHPAHSIGVDLVARRPGMQRPQLAPLVRVASKMKPTSKPLRGQTFFSSSAAPRAPPPRYRRFGDPREPLRPPRAASEQASATSTASPFRIPRIPGLPGLGGAGGRSGQSAKSRGPALGPGFLSRFRRPPAIVALGLGGGTIYYIANLERVERTGRLRFIDVTPEQEVEMGLQSYNEIMRQYRRLILPNSDPTARFVQGVVKRIVEANELHAHSGDGQVSAKEWETHVIRDEQRNAFVLPGGKIFVFSGILPIARDADGLAVILGHEIAHQVARHSAERMSSLKHSPQVLFGLSILLESLGIDPGISRVGLNLLMTLPNSRKNEVEADFIGLQLAAAACYDPRAAEGLWQRMEAAEGGTSSDGLGKKKGINMDFLSTHPSSHRRVEKVREWAKDALELRPDRCGPLKEYSVGFRQASGTRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M133</accession>
    <name>A0A2X0M133_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C018g08587 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C018g08587</name>
        <name evidence="3" type="ORF">BQ5605_C018G08587</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY25154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M133"/>
    <dbReference type="STRING" id="796604.A0A2X0M133"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015943205" evidence="2">
        <location>
            <begin position="29"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY25154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="293" mass="29892" checksum="04FBAF80A10F9FBD" modified="2018-09-12" version="1">MLLPTSTSRWSALTTLVMLASCVTSLDANPSPQSTTPALLAMNLAKSPKVIRVVQESQDATASILSRKLDVVTPKKRQDDQLPIKRRTTVSSSAKKSDVRKKRSLPRRETMKGRENRKNKRAGSKSSHIKNKLALKAKFKREKVEQVEKASRNKVNAAKTTTASGGSKPRASETKKADSKGSATKKADGTAKSKSGSGTTKAGAASAAGAASKATTMAPAATAPLATAPAAATTPAAAAAAASVTTTSADLITSTAAAATTTTGPNSSAGRGASLMSVGSMTGLLAVVLTMLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M150</accession>
    <name>A0A2X0M150_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BQ5605_C083g12988 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C083g12988</name>
        <name evidence="12" type="ORF">BQ5605_C083G12988</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000034">
        <property type="protein sequence ID" value="SGY28146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M150"/>
    <dbReference type="STRING" id="796604.A0A2X0M150"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="6" id="KW-0229">DNA integration</keyword>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Chromo" evidence="11">
        <location>
            <begin position="372"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY28146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="435" mass="48690" checksum="1EE0230D048B4850" modified="2018-09-12" version="1">MADVSGDRGREDLACTSRWSLSLFVPRGLATGVVDSDKVPSLRELVLAEIHRSVGHAGTSHHPGRHTSFVLVVVMSADCAKFCHSCEDCARGKASTQVPYGRLHPMPIPSGPWEQVAIDFMTGLASDGPPDSPSQPTPTPLVADRYYATIFRLHGRLPPSFSDRDPKFTSQFWRALQAKVGTVLRMSTAAHPETDGSSENRIKMVTPNPAHHGVATYGYLPRRWPTDSWSVSDVPRAEAFARIRQLRNLDVTDAIIGARLDQTHQANKHRRPDDPAFRTGSYVYLSTKNLAVPEGMKSKLLPRYIGPFRIRAAIPATSSYDLELPPAMSRVHSRFHARLLRPYVENDAERFPGRDPAVLFVEDVADAADNSAIPERIVRDRRNARGNRSFLVRWIGRKDIDDTWMSEQSLRFDHPSLLDTYLAQLDRSNRRLSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M2D6</accession>
    <name>A0A2X0M2D6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C001g00143 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C001g00143</name>
        <name evidence="1" type="ORF">BQ5605_C001G00143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY44332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M2D6"/>
    <dbReference type="STRING" id="796604.A0A2X0M2D6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY44332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="576" mass="61279" checksum="0F5C9A7F2D151513" modified="2018-09-12" version="1">MGTLFRRRRYESMRIMRTLIQGPLIVASLAVGLQLASAAAPLSANDLSLARRNKSNFEAGIKRRDSSCPQVANAVSTCDSSGACDFTCGPNLLKDRDEGKCECILEGCPAVGNSTRFCNASGICDFTCNGDRKKVGDQCVCDTEGGCPSCTPSMCPIVPNAISSCTSSGMCNFNCTRGLIRFAGKCNCNEFFCTTSAFDNASNAWCNNDTGSCDFACNSGTKKVGDNCVCDVAQCSSIANVASSSCPSANAPCDFDCAAGFKRDGRQCVCDDDQCPRVPHAAFSFCNDSGTCDFDCADRFIQKDRQCVCDPARCTDVVPNGASVCNSDGSGCHTTCNVGFRLAFGQCVCDVDQCPYITNSFTFCDHSGACGFQCYPGYRKENGQCVQGSIGAALCRVNECPVIANGRRICNSSGKCDFTCLDDFTKSNGKCMRTRCTKASQCPAVANASSICSRHACSFECREGFRNVNGVCVPKPAPCTKKSIALYQGYQSGKRGQRPATVTSVEACAAYCVLRKCVSFDFYNRNQCEIQIGGGGFDRFGSAKRVVHGVPGKCSDFIGSIPIKAAGKACSNLQVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M4I1</accession>
    <name>A0A2X0M4I1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C003g02013 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C003g02013</name>
        <name evidence="3" type="ORF">BQ5605_C003G02013</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY38373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M4I1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="442"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1009"/>
            <end position="1035"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY38373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1275" mass="143271" checksum="47A77291F03009F8" modified="2018-09-12" version="1">MSPSQKQKKNTFDIEIINMYAPVQEDDRRDFFGLLHFNAPRPKTLRILAGDLNDCPDVSVDRVSITDRAWTPVSHWQTLLSKIAFNALDTVRHVHSCTPAFTRPHYRGRGEERKICSWSRIDYILVQCSWANRLLSASTLFDAPCSDHRPVVATFALPTSNAADAEPPPALPTTSEFISRLNPTVFNDQDFVDSIPGVVDEVYRRLEGTTPLGDVYDAALRAVAAAGHAQYRSTRADMRRLRAENQSVMEALEARGEHMNEAERDAYALAKSQLDQLAVKEAQWLRIRAHVPSVDSREGQSASIRTRLNRRSRQTSIVSLEDVDGTETVDMQEALGIASRHAQSLFTPDPARGDPTNARRSLLDPIRAAKCYDDDRSDPTFGRRLPLQARVALDEPFNLSEVKAALKKTDSGRSPGPSGIPYELFKALPTYFAPKLLDLFNSIWEGGKMTASLAEGLVRLLPKNKPGANLKSLGAYRPITLRETTYKVLSKVLVARLNGVLGELLPPAQHGFMPSRRSADAGSHLTLLLKKLKSLGTEVFPEGALLSLDQQSAYDRVDHAWIFDVFEAFGFGERFISLLRALYDPETLGVRYLINGFPTELVRLLCGLGQGDPLSCPVWNITFQPLLDALVRRGIALDLQKVWPGGPRAQLTHLAFADDAVVVVESPAALSKLETLSQTWYEATNGKTNTDKTLVLPLGPNWLRDETAQALPTVQEGESFKWCGYAFFRHGDSKLFWTHVLDRIKAKARAARDRTLSPSGRVFYANAHITSTVLHVLSFDIPPQWFIQAAETALTDFVWGGPRRNTVAREFVFQAREDGGLGLISIGDIVHLVALRFWDAVAGSDEAIWAPLARESWRSLVAATRDFSPWGFFSSTARVEKLYRDSARWGAVVAAARVTLPTIKSNLLTLPELLSLPPRLPSLYAEGAKHAYDDADAVAKFAQIADLYWRDEGKGWALVGHRRGFWQHSKEPALRHEHVWARVGQKLKAKALLPKTALRQLVNTVRFPGKDGQDRALPGGQPQEPRVKRFPEGTSQSGRQRFWSWLHDRFASAAEQDTHWRLMYDVTPTRKKQHVQGHASSPLCLFCGNDAAVIETVSHYFFGCAYSASYWSGVLRILFDKLGIEDTDVDPSTFTQEQLTMGLPLLRGRGRTTSKWMWVWLACAIGFQRLHLLRWHVHQRFEKDRVVAPPLIPSALRTFKRDFLSRAGFVPGARDWEWQSLFLDVGSASRVNRFWRLCEKARSFYWIVFCRLPTAQPPALETQPRRDIRRCRGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-05-29" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M4N7</accession>
    <name>A0A2X0M4N7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00930 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00930</name>
        <name evidence="2" type="ORF">BQ5605_C001G00930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF8 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY50827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M4N7"/>
    <dbReference type="STRING" id="796604.A0A2X0M4N7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016689">
        <property type="entry name" value="ESCRT-2_cplx_Snf8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806">
        <property type="entry name" value="EAP30 SUBUNIT OF ELL COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806:SF0">
        <property type="entry name" value="VACUOLAR-SORTING PROTEIN SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY50827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="272" mass="29399" checksum="6B17D48FBA293D04" modified="2018-09-12" version="1">MARRTGVGYTSLQRHLDSQSHYSTLSTSLLSSQAQSLQAQLQTFTTALASFSTTHRARILSSPTFRSEFTRLCAELGLDPLGGGKKKLWDRLGLGEWYVALGVQVVDVCLDLRDATGGLVSVEVVLQGVRKLRNGGKNDRTEQVTVGDLEKAIQVLEPLGCGYKVVSSNGVENHSDAGAKSSASATSNASIKLVQCRPQALDTDSFVVVQLATEKGYLTVEDLVRFKMGEGWGAERCERALSKGVESGLCWVDDGGEEAAEKRYYVAGLWAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M562</accession>
    <name>A0A2X0M562_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g03839 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g03839</name>
        <name evidence="2" type="ORF">BQ5605_C006G03839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY54098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M562"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY54098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1140" mass="125325" checksum="1314C5EE424BD20D" modified="2018-09-12" version="1">MSAPLYDKNNPIPGILPQATQTVKLVFDALDDGCLTQEAQTNLISKLSDDAGPPRRNSSAEAELAFWLAQVRAIPLGVKLSLETTSNLHPVVASALVSEDPDAFFAASSSRYWTNDGLYRRRAPSAPAQTLTDSNTPGTDPAPGAHPAPPGTTMRPQTVPIEGVGDVPAYRVNDLPRGTDDKFLAVDRLFVDSTQLDMADFPAGCVFQMIPLPKNTLVSTQAAIGEDQWVDEESQRMDQLIQLAGSAPARPPISRAQTAPSQVLSSRFPTVQQQLGVVPPLPAGSQTPLVGVLEVEDESHRYRLGRLTAARFTPAYSSDPKHAGVFRTQLQRQGVIKMDVIEVMKIMSGGFVDISDVVHRQEAELFDSYTDNNGIEFKGIQARAQKKASRTKPPVTDFSKFIRALKEIEAVENAVFGTYDGADWTHYLKFLDEMHAGAQNGFKGAKLPIAFDDCFCRMRAEPNNRVTSLLEASKSHAAYVNTILLVAALPNNPELEERTKSSNGKDWICIRYNRRQPHPLASCGRKHVCLDCKAKDHRSGDSGCPNLEIGIGHKLAKMAAKSSAHQVPLSPHHDSPYDSWSPPVHPPPSLLAGIRPAPRIQRRFHFGPLARATYTPAQLHLIRRAHRMYPSQFSFVRTIDDTKFETLLLQHPNRALVRSFIHGFRSEGFEPEHDGSVASGDDPATLTFPRSEDHRSFIQTTIDDEVAKGWLSPGTAFPIPGATYNPVFVVESANHRMRVVADHTRSGLNDGISRAACPTVYDSIIDFICLLRSTSLSAFKVLVMSKDWQARQGIAIRCRLPDGALVTWYHIEWRGVFGCRAIPFLWTRFTSLVVWIAHHSYGIEHPLAYMDDTFGVNIEGRLVSFVHNGETHVIPSQQARMATLWSSLGLPFKLTPDKAPFGQRVTITGIYCDLDDFSISLTPKAVNDLATAIQAFLDFPGRCPPLRQWRQMTGWLSWALNIAPQARPHVTPLYNKIGTKTAAQRWCPNQPGSPQGAHLHCPPFAEALTVVVALDLATSGAFGSSRRVLVRTNSAPAVYALDSGACSDTKFLPLRTLTLRAFATASSRRFDLKVQHVAGDAVMTPTTPGVGRGVSFASRPLPGPHLHTVHPLADDIAFSNELVARALEPRTRSDYQRSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M5Q0</accession>
    <name>A0A2X0M5Q0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C006g04016 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C006g04016</name>
        <name evidence="3" type="ORF">BQ5605_C006G04016</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY55401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M5Q0"/>
    <dbReference type="STRING" id="796604.A0A2X0M5Q0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058912">
        <property type="entry name" value="HTH_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301:SF10">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26215">
        <property type="entry name" value="HTH_animal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helix-turn-helix" evidence="2">
        <location>
            <begin position="357"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY55401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="514" mass="58299" checksum="4C61B87FF5C26BCE" modified="2018-09-12" version="1">MVVTAWIGKKARSFYWIVFCRLPTAQQPALETQPRRDIRRCRGDDPSPHTGAAVPAEKCEPPRSSRTTVIESNQVLPPQSELCREASRLAHATQSFSTESPPPGLRTGFQYNQASFPLSLAVQDAYSPHVEATSYGTDAQPYSNKRGTHLEPRGARCMRWLGTHFYTQEHLPFSQRLPPILAPMFEDFLDSGSENFGFGSAPSSEFFNTETLREQTAGDLIYELVSFVLNNSYLGFQGKLFHQVSGTAMGTALAPTYANLFVGALEREARLLETPNLIFYGRYIDDVIAIVKGPRSNVDICISALAQLHPSLVFDAEVSSNGLPFLDAFISKNPDPKNSSRWSLSTRVYQKDFNSYQYIPWSSEHPESVKSAFVKGELIRYIRLSSSRDEYITQMTRFYLRLRARGYPTRWLRKAFKVVQYSDVCPVALERKQIENMGETPLIFHSDYNPVWNQVNAGLILTKTVEDWNPDLRTKLTGTKSRRIINARSRTRNLGEIVSWRKPREVLGARKLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M5R5</accession>
    <name>A0A2X0M5R5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g02362 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g02362</name>
        <name evidence="2" type="ORF">BQ5605_C003G02362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY40374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M5R5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY40374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="296" mass="33405" checksum="3AC9A892F530C1EF" modified="2018-09-12" version="1">MSVQTPRPVRGPPCRHPSIEFRASPLRSASRASPTTPAPNHSTNPTTVLGHWRPRLTHEDRRDSSELRKKIKIEAIAALFKLDQFGSRDRYDAVFVTAPTGLGKSVIFEAMYLTHRRRAVTIVAANLNRQGKKAVVCTCVDFPSCLLRVKSPEMHINNADWAKLISNESFRERVKLLVYDEDRGWCAFTTTGIDTAKDRGYEIQRIDPPRGGCSGELTRYGVCLFGSFLVLYIVALDVDDGDREKRRTAKRTQGDQAERSRLADDESANYTMRSDHLRPDRPRSQTSDRCSSTHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M7E4</accession>
    <name>A0A2X0M7E4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00458 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">BQ5605_C029g10622 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00458</name>
        <name evidence="3" type="synonym">BQ5605_C029g10622</name>
        <name evidence="2" type="ORF">BQ5605_C001G00458</name>
        <name evidence="3" type="ORF">BQ5605_C029G10622</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY46662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ14839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M7E4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY46662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ14839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="57" mass="6325" checksum="1698D1A92F9C63C8" modified="2018-09-12" version="1">MALVWAWGRIPSRHGPAKKPAGQRKQGEANRGGGRESKNLWSFERATGDVASENSWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M7G4</accession>
    <name>A0A2X0M7G4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C007g04627 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C007g04627</name>
        <name evidence="3" type="ORF">BQ5605_C007G04627</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY61942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M7G4"/>
    <dbReference type="STRING" id="796604.A0A2X0M7G4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019417">
        <property type="entry name" value="DUF2415"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991:SF9">
        <property type="entry name" value="DUF2415 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G05640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10313">
        <property type="entry name" value="DUF2415"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2415" evidence="2">
        <location>
            <begin position="376"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="626"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY61942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="693" mass="76304" checksum="EC6CA289AAE84687" modified="2018-09-12" version="1">MMRLQPHAAHSTALTTTASHPQLRDLVVCPPEDPDAVVVVCYDRIVRHSLLHNVDPIVTKLNFCPSTLAYGCGLIAVGGQLSELALRSAHPDATWSVPSRHSHTITCEFSLWSNLFLRSHQTIDSPAGSINNSIFIGPSPLLPDRPRLLVSNNDASIKIYDVAGEVPDFRAGARRRKRTRRQFNLGGSSERSLTMTPVGRAEWGGRVDATMSDSSTSYPPIRSLWLDQSTNRAEEVSNDSSSNESIEEHGTYDTGGTCRLVPLGHSRDLHFDTAINHTSVSPDGRRLVAVGDTNEIFLYDISLLGEYTFVHSFEASEDASFSSDWSQTGDKFAVASQDGYVHVYDVRYMPRSGSGPSESPPRKLATIKSTQAGPPGAIRKAKFSPGNRVDGELLAFTEHRSKVHIVDARTWDQSQIVEVLPPRNSDRVYSLGQEVPLPPPSRRPVQAEGQASGNAIASTSYGTQDVAYRRLLQGASGLFSREAIEVSQRLRERGMADNPEQEGTTATIVHSRRRPGQGRGMYEEDEEEEGDEDEEVDDEEEGEEEECPPDTSTIFIRSSAPTNVAPTLLNRFLPDPRQPSSTQTFGSAPPFPLLQPPTTTAGRSPPPGWRPGLSGYTPLSTYSTFISPGRAGSRRTGYQPTSQYFPTDSTPMDLLGLDWDEEGGRLVVATEGRVWEWNVDRRGRRCFGEVEWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M7P9</accession>
    <name>A0A2X0M7P9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C007g04727 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C007g04727</name>
        <name evidence="2" type="ORF">BQ5605_C007G04727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY62725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M7P9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015992076" evidence="1">
        <location>
            <begin position="19"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY62725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="85" mass="9252" checksum="A22244DD2ECD24F0" modified="2018-09-12" version="1">MKVPNLLTFLIVSSVALASELRGDQRVKSSARQKRALAVDDPNNFNFFRSCAESCQYSPKSGHVTTAEASCYKGCMSMANQGEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M850</accession>
    <name>A0A2X0M850_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C001g00697 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C001g00697</name>
        <name evidence="7" type="ORF">BQ5605_C001G00697</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY48817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M850"/>
    <dbReference type="STRING" id="796604.A0A2X0M850"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019459">
        <property type="entry name" value="GRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000237">
        <property type="entry name" value="GRIP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921">
        <property type="entry name" value="MYOSIN HEAVY CHAIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921:SF2">
        <property type="entry name" value="THYROID RECEPTOR-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10375">
        <property type="entry name" value="GRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50913">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRIP" evidence="6">
        <location>
            <begin position="419"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="472"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="530"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="119"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="42"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="530"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="604"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY48817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="628" mass="69731" checksum="BCF2C76ED4317B7C" modified="2018-09-12" version="1">MMAEEGDTPNPFEHAEQDDASWFGNEDDSQAMDRATPDADVEEQHHQPQPLHDHGPETETEHEQHGPEHAQEHARDDTATITNGHDPQEAPTEEEAHHPEEHEHEHGEAGPILDGTDRVAELEWELQRTREDKQAFEDKYNGLLSKLTTMRNTLGDKLKQDADELDRREQEINELRLHIDDLASTIDTLKAELIQAHEDSERLHTELESLRARAFDSQKGLSDEAAEREMALRDAQEEAERIRIDRDEWEGEAMRERVKREELSTRLGQLEMELGQCKADRDAFREERDREAESASNLQTVLEEFQAAKEKELRSTTGDLQAQLDRAHDSIGIWKQRAIAAEANLASAQNDSEKVITLSKELKEKTLLTGKLRHEGESCSQPQGMALRDGMTDSKRDDPPAVILNEHLTEALRRLKKDSSENSVDRRLVSNVLISFLNTPRGDTKRFEMLQLLSSILSWSDDQREQVGLQRSVAAGSSGRTGRGHARSLGAGTGKGKAAATTQEEEDGLGENESFSNLFIEFLLKEANQAAPSTSTTLPKKNVDGMSSPPGMTSPISPGSPGLSPPLLGPGRSRILPELGSPPPQSRRPSFTSFFGRGSRDQDPSSSQANGTASAPSLARNSTDVIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M875</accession>
    <name>A0A2X0M875_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">BQ5605_C001g00708 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C001g00708</name>
        <name evidence="14" type="ORF">BQ5605_C001G00708</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY48879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M875"/>
    <dbReference type="STRING" id="796604.A0A2X0M875"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22948">
        <property type="entry name" value="Coatomer_WDAD_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000010">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047312">
        <property type="entry name" value="Coatomer_alpha_WD-assoc_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF1">
        <property type="entry name" value="COATOMER SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="7"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="49"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="91"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="133"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="207"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="251"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="12">
        <location>
            <begin position="345"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="13">
        <location>
            <begin position="610"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGY48879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="705" mass="79811" checksum="2E6612392A3BB127" modified="2018-09-12" version="1">MQMLTKFESKSNRVKGIAFHPRLTLLAASLHSGSIQLWNFQMGVLVDRFEEHDGPVRGISFHSTQPLFCSGGDDYKIKVWNYKTRRCLFTLHGHLDYVRSVYFHHEHPWILSASDDQTIRIWNWQSRQCIAILTGHNHYIMCAQFHPKEDYVVSASMDQTVRVWDISGLRKKNTTAQPLSFEEQIQRANSGQADLFGNTDAVVKYVLEGHDRGVNWATFHPTMPLIVSCGDDRQIKLWRMSDTKAWEVDTCRGHFNNVSVALFHPKHELIISDSEDKTIRVWDLSKRTAVQTFRRENDRFWVLTAHPELNLFAAGHDSGLIVFKLDRERPAFSVHGNTLFYVRDKFVRAHDFTTGSDASVISVRRLGSQFVQPRTLSYNPAERAVIVTSPADNGLYELVHLPKDVGSGEVRDSASEGRRGTGSSALFVARNRLAVLDKTAQTIEIRDLENSITKTIKCPVQTNDIFFGGTASLLLSCPASVVLFDIQQQKIIAELATPLVKYVVWSNDNTMVALLSKHTIMIANKTLGQSAMVHETIRIKSGAWDDSGIFIYSTLNHIKYALPQGDNGIIKTLEQPVYLTHVKGKVVHCLDRNAKPRAIVIDPTEYRFKLALMRKNYDEVLHIIRTSNLVGQSIIAYLQKKGFPEIALHFVQDKTTRVDLAIECGNLDVALEMAKALEREEIWARLGQQALKQGHHKVCCRGLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M8L4</accession>
    <name>A0A2X0M8L4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C004g02750 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C004g02750</name>
        <name evidence="2" type="ORF">BQ5605_C004G02750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY67165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M8L4"/>
    <dbReference type="STRING" id="796604.A0A2X0M8L4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097020">
        <property type="term" value="F:COPII receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007277">
        <property type="entry name" value="Svp26/Tex261"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04148">
        <property type="entry name" value="Erv26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY67165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="132" mass="14135" checksum="16AB4D0801C529FF" modified="2018-09-12" version="1">MPTALHLLSYVAGSGAFLVVLLSFGEFDLVSITHARKRRPGPGAASSQFSHFRIEFGLLYLAEVIEEHAAQAKVMGQRMVWVSAGPHAVFAVVVVDWCDRARLACSARIVVDSALVNAPMRKSAVGRATEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M941</accession>
    <name>A0A2X0M941_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g04145 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g04145</name>
        <name evidence="1" type="ORF">BQ5605_C006G04145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY56554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M941"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY56554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="195" mass="21821" checksum="8ACA3A4CFBDCC418" modified="2018-09-12" version="1">MIVRQGKVKRMLEWLSHVCAFSREHLPPERQQPQHLIREIGLELVTSEALATQGMESELRCLFSEHAATAWSLGNGQSIEVNMPNLTAKPQVVFIHHQLIIPKFIGKMHKRPIARENLLDLPDYSRFHADVREGLFTSRKCAEGSPTPLPVTVHGHPGRFACTILREGDLCALVCTVEARAWRDRSSGKCIGTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-02-22" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M9K9</accession>
    <name>A0A2X0M9K9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g03914 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g03914</name>
        <name evidence="2" type="ORF">BQ5605_C006G03914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY54822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M9K9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08284">
        <property type="entry name" value="RVP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY54822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="359" mass="39561" checksum="1E2BA3B0CC57EC24" modified="2018-09-12" version="1">MLCVSLVRPTRAIQERVEIVQRGRGELLQGKHACVEGFWRAAGCCCKHKMDQKALSYQRLIRVSSVNSTYFGPEKEDSSDDEQEGCFSCRRINTDHHASDCTANWQQAPDVPEGWAEFEKKKAKAAKNDTLHRIAEDSEDDISTDEENEYAPQFISTIPITLHNDTNSKTLQALADSGASSSFIADKVVEKLGLVVHCLPVPTLVKTAIKGQARAFHVTSFVKIPITLENGTWEAGHTILKVAKLQEPLEVVLGFKFLVKHKVTIDFSAHKILVPHPTVPDVKIDLLAPVFGPHPQRGAARNAKRSDKARINWSAVIAYIDGVLWYSGSRWSHFGRISGSGVESSHFEPGSGVISDVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MA09</accession>
    <name>A0A2X0MA09_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C005g03162 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C005g03162</name>
        <name evidence="7" type="ORF">BQ5605_C005G03162</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY72355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MA09"/>
    <dbReference type="STRING" id="796604.A0A2X0MA09"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06466">
        <property type="entry name" value="p23_CS_SGT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1130.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007051">
        <property type="entry name" value="CHORD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039790">
        <property type="entry name" value="CHRD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46983:SF3">
        <property type="entry name" value="CHPADIPLOID STATE MAINTENANCE PROTEIN CHPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46983">
        <property type="entry name" value="CYSTEINE AND HISTIDINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04968">
        <property type="entry name" value="CHORD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51401">
        <property type="entry name" value="CHORD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CHORD" evidence="6">
        <location>
            <begin position="6"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="CHORD" evidence="6">
        <location>
            <begin position="148"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="CS" evidence="5">
        <location>
            <begin position="225"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="67"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY72355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="360" mass="38943" checksum="95C1DF285236941C" modified="2018-09-12" version="1">MASTTCTRKGCGKTFDESNNTQADCQFHPGAAVFHEGMKSWSCCATTNKPVTAFDEFLALPGCATGTHSSEKPVAPPKPTVVESTPAPVATGVNGQETYGAPVTSLPPPPPRAASSSSATLKDRQPVSTEYVEEQDDPSLTVPAGARCKRRACGATFEPSTSRHDTECQYHIGVPLFHEGSKGYSCCKRRVLDFDDFLRIEGCRSGKHLFVGPKPKSGQEEEDQLVECRVDHYQSPRSVCVSIFGKQADKDRSSVRFEVEEVSRLKAPCMHVDLLLPSRKRFTKSFSLYGPIDPATSTFKILGTKCEVTLAKADARSWPSITKLSEDVGFIPQLAFSAGGGRGTVGAKEAILDNQNKMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MA46</accession>
    <name>A0A2X0MA46_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C005g03202 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C005g03202</name>
        <name evidence="1" type="ORF">BQ5605_C005G03202</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY72734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MA46"/>
    <dbReference type="STRING" id="796604.A0A2X0MA46"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY72734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="98" mass="10844" checksum="06B0DDEA8CBFD3A3" modified="2018-09-12" version="1">MTGNVGGVPEVGNATASYDRNSTFRHLPTHLQGVYYPYASSEYSILYRPLLPVKNNGVDEFCGNIKGFKSRLIAEPGENWQYGVSIDQAVEYLQRVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MAS7</accession>
    <name>A0A2X0MAS7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C007g04696 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C007g04696</name>
        <name evidence="4" type="ORF">BQ5605_C007G04696</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY62472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MAS7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015995705" evidence="3">
        <location>
            <begin position="20"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY62472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="230" mass="24856" checksum="5DB6DBEF6B2BF3BF" modified="2018-09-12" version="1">MACLAIGSVLVSSIALTFYDDCGERIVVVRKGIEGSRRRVRGSIEDVRAGVGRVVGGARGAVELVVWATSARMPNTSVLDNVELDLDYEPFAENRDAVTFSSSSSTAASQPGTTPERGPTLRNCQSSTTPASRPPRDRQSSSTSSRDSGIWTEHEEDNLPFNAPFTTPHPSRSASPTRGARGGNDQAPPQLPPRPPLSILVPSIIFALTYTIWTVLSNFWRMQTADKRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MB49</accession>
    <name>A0A2X0MB49_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C010g05912 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C010g05912</name>
        <name evidence="3" type="ORF">BQ5605_C010G05912</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MB49"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216:SF65">
        <property type="entry name" value="PAXILLIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="429"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="948"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="369"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY13609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1186" mass="130076" checksum="736836B7C6ACAFBC" modified="2018-09-12" version="1">MDNNNNTNNASHAAIPPLRPDPPDPPGQAPATTTKSYSAAVGARSAAKHGNATANASTAVAAHPLMHNIENCVIINTPPSTSVEQVLLALDKHYPGLTGAASSREVLYNALTAFFSDPEGLCLFDEQIAAYGTVLRRRIQYIGKTKHISGVYEFILALKDVDVLPPASLSIARDGVTERIPLRITGGMRHCVFCRSAAHVRKDCPVAPACKSCASTSHATQHCPARHASSPQGPPTSRAPQASTVTTAAPAAVSKSISPASPHDRTTKKRRVEQDLAAQTEDLSNRAQPDSLSKNARPEFSFNFPCKTATPPAPQPASNQGIAYSLVEKSSESPSSETTSPSPSPPPATPKSIITRSKSIAALSKPATREAPPTAPALEASEPSPEPSSPTPLPSAAPKARPDDADTDDEADEEAEDQEAPPKDSINEDRKRASLFSNLRSHNADVFLLSETGRPSPEKVAQWTQECQDLKLSALFTPFNNTAILWKSDSVVITFDPESPPNTLRASFSFPDRVTDATFCVGDSKVRVVSIYAPSSDKPDKKRFLSHLSTALRQVVRDEPSPPALLVGGDWNCVESQPLDSENQNGTNYGGQEMRDLATANNLFDAYRLHHPKGRATTNRSAPGTCRRLDRIYVSPDWVDLFHDHKIWAPVLKSTHSMVVARFQVPGAIDIGPGKFKLGLHVIEGDATCEYLTSIVRTLYNKALLQTPNDPPAAWTSTKHRLLPELQALARTFARFRRGGSEQERADHSRYGAALRSRLDPSLAGPSSIFIRLRKVRASDLIPSLTVNDVVHSDPDSMLGAASDYFERVYEDRPIDDAALKAIIDGLASTRLSPADSLKLEEAYPLEEMTKAQAAFLCAVGLGPKARQWYRATYTNQSASIFLNGWLSATFDILSGVRQGDPLAPSLFVLAIEGFACQIRLRVKGIDIAGLQNVRELLFCRRRLLRTPQPLGPRPPQSGDRALRTGKCQQAQQRRGGDRRGCGLGRCQGLDHRSIPMYDLPYAAKCSIINIYCYTKILYYSRFLPAPKSVVKEIEEAAMLAIYGRASDGTQRRPKVSRSRLCTPLDHGGFGLIDLPRRLAIDHAKWVFQLRAPDGCFTRHLFDIRIRLQAPNEPTPFTLSRPAPNQHRCPWIWIWWAYFCHPPPKWDHAVRKTTKLLPARWVRYFEAWALVTTLNSPELSKSQNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MC03</accession>
    <name>A0A2X0MC03_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C008g05096 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C008g05096</name>
        <name evidence="5" type="ORF">BQ5605_C008G05096</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MC03"/>
    <dbReference type="STRING" id="796604.A0A2X0MC03"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF77">
        <property type="entry name" value="FI19380P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016143159" evidence="3">
        <location>
            <begin position="26"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1023"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="4">
        <location>
            <begin position="305"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="4">
        <location>
            <begin position="467"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="4">
        <location>
            <begin position="662"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="848"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY79289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1064" mass="115273" checksum="0166CC79032C6C18" modified="2018-09-12" version="1">MIIRFGSIPSLLLVTFLFVPSFVLAASSASPPLFPPSARSISLVDLLNDSPEHSMLLSALQRARLIPTVNLLNGSVLWAPTNDAIKAEIEHEKQYASHLAEQHSAERHRPSLNCSTSGDVVRATNTPIWSYAVHGSSALMTSNRSEERDNLQLELRDTLLYHMFNYTVFPPPHDDTPPPSDNRTSLMSNGSGPFDDLPLDRVILHETLYHPSLSSFNKSFPAPPSLPGSPPDNPDPDKPHKVEGLLRGQGQRVRVVRKSAIKKGSKEEVWIGGDWRGEGGAAAENKVLHATNGALVSLTAVLHRPVDLAAHIRINPDLSTFASLLPESLLNYIATAPHLTLFVPTNEAWASLSDLELKYLKSGFAEKDLIEIFGARASREGVGKGKVGYVSSLFGKNSTNTTTAMRTIWNSTLEIAMDESNNVAVNGTRVGTPDILALNGVIHTVPTLLLPSGSLSLTAEKYLIALEATRFVSLLRSVNLSHYVQIPSGDPAVMAASYSSSTSQSTFAAPLDGAPAYTILAPPDSVLQNERKFLKDEDAVYSTAVTVSGASLPPAGSDALKEFLLYSIVSGKWLPEDLKDGMLVGTELRGRNLRDARQRLAVNVNVASQNLASIGWGWWSSEDPNSERKPGLVGFGGASVIREPVVVGNTVIYLISSTLEPPAPIINQAVSDLRLSTFVASVYAASLDHTLGHQPAVTYLVPDNEAFTSLGLVMSYLLLPTARAELRSLVRYHAIDEIVYFEDFPRTAAARYPTLDSGAEILVRHDNGTVLVHGPTSGGLATNGEVRDARVIEGNILTATGAVHIIDQVELPPTLNITAVKLMRGAKASTMLELIRAANMTWVLEGRSPPPTESLLNGGKNGEKDKKPKVKPEYSAYIILCPTDKAFSRLNISHYHANPPLLEALVRLHVIPVDPFMPLKPDGRPLALADDALFPTLLDRSEGGESRYGSIAFRRWGDDDWLVGINGARGTGGENDSAKIVSYGRATPSFVDVDGQGRRLAGGGVLMIDSVLLPYNPGWFRRFGWIILVAVLGTALVALTGWGGWRYYRRSRKPPYEPLEGEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MEM1</accession>
    <name>A0A2X0MEM1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C015g07862</name>
        <name evidence="13" type="ORF">BQ5605_C015G07862</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:47005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MEM1"/>
    <dbReference type="STRING" id="796604.A0A2X0MEM1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000016">
        <property type="entry name" value="Protein phosphatase 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF565">
        <property type="entry name" value="AT28366P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="12">
        <location>
            <begin position="23"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="370"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGY17697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="412" mass="44518" checksum="04C907800BA6859F" modified="2018-09-12" version="1">MGQTLSEPVVDKHTASGEDERLMWGVSEMQGWRTTMEDAHAHVLSLGPERDGAKTSFFAVYDGHGGSTVARFAGDTVHHRLAANEAFKKQDYVAALKRAYLETDEDLRANPDFVGDPSGCTAVSAIITSDLTLICANAGDSRAVMSLGGEAKPLSFDHKPTNRAEKSRIVAAGGFVEMDRVNGNLALSRALGDFEFKQGANLEPEHQIVTADPDINIHTHTEEDEFLVIACDGIWDVLKSQEVINNVRLGIAERKELSTICEDLMDQCLAPDPDWGGLGADNMTAMVIAILGNRTKEEWYDWVAERVEKGVPYPTPKEYTEPFASGGQSSAPTSILSRTRLQALGSEDDDGDESELMALQEALKAKMREHLLSLERDDEPTEAAKDGGAAPTSREGSAGSVTSPPGEDPKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MF89</accession>
    <name>A0A2X0MF89_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C014g07467 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C014g07467</name>
        <name evidence="9" type="ORF">BQ5605_C014G07467</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RPAP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY18765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MF89"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039913">
        <property type="entry name" value="RPAP1/Rba50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013929">
        <property type="entry name" value="RPAP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013930">
        <property type="entry name" value="RPAP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057989">
        <property type="entry name" value="TPR_RPAP1/MINIYO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483:SF18">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08620">
        <property type="entry name" value="RPAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08621">
        <property type="entry name" value="RPAP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25766">
        <property type="entry name" value="TPR_RPAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RPAP1 N-terminal" evidence="7">
        <location>
            <begin position="228"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="RPAP1 C-terminal" evidence="6">
        <location>
            <begin position="354"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="RPAP1/MINIYO-like TPR repeats" evidence="8">
        <location>
            <begin position="1004"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="176"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="181"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY18765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1316" mass="144602" checksum="1B3CF041F9DD62A3" modified="2018-09-12" version="1">MDAQRIRPSLRDLSSPDADPNSAKFSSFGTAVTVTRRRPPQVGSSAMRTSAPDHVPVIFDREPIPDSAGQTAPTAPTAPMAKPKSRFALHRERERREEALRVAVHGQVQGEASLHHNATGAYSLVGQVVERASSELSVEPPRPVPHLLGAGASPSPAALPLGFPVSVRHTPTPLKEQTQVLPQSKPQSQSLPSSSSTAWTSKLHSPVTTTREVGDIHNPNSMPAILASVSDENDRLLAGMSDQEILDQQREIKESMGLSDELLKILEARSRRSKVLPSMESDLPTTSTAQVQVGGKGLLQSVQDDTNDAEGSPESIRKHYFPQEPASANLDWMKPNQTINARVDSAGHYRHLVFSLNGAFISSAEGIGEAPKVSALHHVSSSSAFTITTLMSLALSSVPSQRSSALQTLLRILSCTPSHEPKFGKEAWLRLELDIAQRACHALLDATVGVRSVALDLLSFLIETECRRPREAFSWIRPQGLEESSLLSTLLIALPFAVLEQELLHARLPTSASRQVLRILKLFIQLTLDRSSPPFVELDAIVDTPNLLEAVTKHFIAIPWPRPAAQDPTVLATAADALAMLSDLARSSRARTKSIVSRYLAEPALRFLGVPPWELDSASPAARWLTYGLVNATFDLWQTLAQYGLGTSLRTTAASLLSSVLDRAAFLLGDAMPIDACEIHMVVALLRLLRIWTITAIDPHVSEHDILWSHIDGWENLALLAHRRGLQDASPTLIAAAWNLWTVWLEGSKVNSAWRGEMARNWIQEHVATDFEDGKIAILAVKTAFDRIKCLDITRSIGFDAELVVAAVRFSTTFEEDSNLSTPALFYLDGSSVVSFFDSVVPKMAVMRSPAPDVSLVQLLILLLRHIPTTSIRFSRTVDTLRFLRAGDEVAARDLLEWMIRVVHPFANHSMPPLASLDADLELSALSNAAVLRPFLMHAVITSSGGRVTGPDHPTPRDIKLTACLPPFCSKDTLLHSDWPLVALDELLRSGTSPVFQSLPKDWNASELDLVRTSLALMRLVVNTGEVSARIQPRRMIYDLIKVFMLETDNPITPSTRQFYDPASTDLYRHQGVDFSLRNLLTLWSVAVVPQQLNKADARSSEDTLEGHSATVSSPPFYRTYSDLLGLYDSISLGHEVFAWVLLPPLAMSYPVEYRRLLWNDYAHLLRQIRTRVEDAISDCDDPEARLSCFLAPAETDLTVLCAYAKALSLGDVTQAQTPLLYLIGVHHLANALFSASVDSTTRSKLADAVVVGVSDEVFKALARYDQAKDGAALRWGATVWLQDDDDEVKRKWTALRGLVSQSNRCRLDKLISVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MGE5</accession>
    <name>A0A2X0MGE5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C009g05423 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C009g05423</name>
        <name evidence="2" type="ORF">BQ5605_C009G05423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY80964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MGE5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="1">
        <location>
            <begin position="440"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY80964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="737" mass="82523" checksum="5FBD08BB9551F56E" modified="2018-09-12" version="1">MHADRYQRVAPLRLAQAYSDLVFVYLCNPRPGASLRGLPLTTAYCTLSSSAVSQVVLKTGWVSELVIKLTERLEAVPRNFDPITYYYSISPGLHSNRKTPIDERLKEELGSRIPYSPNLHTFIASPEPELDALVEDVTFAGTWGQEEPMQALFDQINAVVSSKVLHTEGSGVMHLTEHGRFVLQGPAVRRIVASGGLSVPVPTSEEQQHHTDQAPDAVTLFTFASNEAIEAAWKMSNEDWRREEARLGRHPTDRRQVNQVLVPGEIKGGPKAGAAARQILRRFYRLKSTVALREFVYGFTLAVDRFRVLCHMPGGIVQTNEFDCSRPEGFKVLLRFLVRLVVDTELNLGAIVSGAAYPLTVNTLPPFVYQRPTSAGSAANVHHRARLWAPTNRNDAMTGNRTAYYPAAVEKDGATASYRRSPEQTVAFSFPTSEQSKRTIRLLERLDTFHSTTIEGLATVETIYQDPQAFRTAPPDVCGGDAGCLSGGVTSRTTQFIEYRELYQSILQAQSTHHLTQLILDAVKGVRSLYQIDVLHRDLSIENLVIKPDGTGALMLSDCFCFLDDALSEQERLEAVGTLATMARAMLPTNKSRIKHEIWHEIEQLVFDVLYVISSRPLGPNNPTRMSREDEETWSTWDRIAPTLAILKSDPFRSRTSWRSQLERYKYFWTDIDHLVQVLIKYCGLGMVSDTTTIAEEEVALFAEWGGRDGATRLLDQLVHDLEMLASTLALQNMQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MGR3</accession>
    <name>A0A2X0MGR3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoribosylformylglycinamidine cyclo-ligase</fullName>
            <ecNumber evidence="6">6.3.3.1</ecNumber>
            <ecNumber evidence="7">6.3.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">AIR synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">AIRS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Phosphoribosyl-aminoimidazole synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">BQ5605_C008g05071</name>
        <name evidence="26" type="ORF">BQ5605_C008G05071</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the second and fifth step in the 'de novo' purine biosynthesis pathway; contains phosphoribosylamine--glycine ligase (GARS) and phosphoribosylformylglycinamidine cyclo-ligase (AIRS) activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the AIR synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="18">In the C-terminal section; belongs to the AIR synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the GARS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.1" evidence="6"/>
    <dbReference type="EC" id="6.3.4.13" evidence="7"/>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MGR3"/>
    <dbReference type="STRING" id="796604.A0A2X0MGR3"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046084">
        <property type="term" value="P:adenine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000006">
        <property type="entry name" value="phosphoribosylamine--glycine ligase, chloroplastic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000001">
        <property type="entry name" value="Phosphoribosylformylglycinamidine cyclo-ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000011">
        <property type="entry name" value="Phosphoribosylformylglycinamidine cyclo-ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000018">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.600.10:FF:000001">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="entry name" value="Phosphoribosylglycinamide synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520:SF12">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01209">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 24" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0436">Ligase</keyword>
    <keyword evidence="15" id="KW-0464">Manganese</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12 24" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="25">
        <location>
            <begin position="153"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00020367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00031908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00032931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00033093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="SGY79196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="826" mass="87025" checksum="10655D18BBC3F6E1" modified="2018-09-12" version="1">MATSTDAGRIFEQEALRILLVGNGGREHALAWKLEQSSKVEKIFVAPGKSIVTEAADCLRPSAPIIANAGLTSSNGGTTFGNKVTSIPVKSTDFAGLRAFALENDVNFVVIGPEQPLVDGLETVFRKGASVGIPVFGPSVKAAAMEGSKTFSKDFMARHNIPTAQYKNLHSYNEAVEYVKSVPHNIVIKASGLAGGKGVIIPSTKEEALQGLKEIMVSKEFGTAGDEVVVEECLVGQEISVLSFSDGYTAISLPGAQDHKRIGEGDTGPNTGGMGTYSPAPCATKDVEAEIHRTIVQPTIDGMRKDGMPFVGLLFTGIMLTADGPKVLEYNVRFGDPETQSLLALLAAETDLAEIMLACVEGRLDSIKIAMKDQAAVTVVLASKGYPGKYGKGVEISFDELPKDVVVFHAGTAKSTDGKVVTDGGRVLAVTATAATLKEAQALAYKGVACVHFEGATFRKDIAYRAFLEGSAAAAPAGFTYASAGVSIDAGNALVDLIKPIVKATKRIGSDSVIGGFGGLFDLKAAGYKDPILVAGTDGVGTKLKLAQNYNKHDTIGIDLVAMSVNDLIVQGAEPLFFLDYYACGHLDVPMAADVVKGVADGCIDAGCALVGGETAEMPSLYHGDDYDVAGFAVGAVERELLLPTPNIAAGDVLLGIASSGIHSNGFSLVRKIVDAYGMDLHASTTWNKDFELGAALLEPTVIYVKQLLPSIRRGDIKGLSHITGGGFTENVPRVLPKGVGCWVDASSFEFLPLFKMLMKLGRVDPNEMARTFNCGIGMVVVVAKEKAEQVKKDLEANGKSKVYQIGKVQEGEGCVMRNLEAWSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MGU3</accession>
    <name>A0A2X0MGU3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C033g11150 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C033g11150</name>
        <name evidence="3" type="ORF">BQ5605_C033G11150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000066">
        <property type="protein sequence ID" value="SGZ01513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MGU3"/>
    <dbReference type="STRING" id="796604.A0A2X0MGU3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025066">
        <property type="entry name" value="CCDC174-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15885">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15885:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13300">
        <property type="entry name" value="DUF4078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="35"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="133"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="304"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="319"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ01513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="349" mass="38550" checksum="042E83C36C9E348F" modified="2018-09-12" version="1">MSSSTPTASTSTSASTTKVKLASSSLLALKAEISRKTTTATASSSSSSCTTRSYTRGLPSSTSGPKPISPWQRSNPGLAARQAKDQIIYETDLDQTGRINTVRSNLEQKAKLYERIKKGKDLGVDHHKVSQLLVDFEAKDEQTDSEGEQDSSEEQEDSDQAQAGEDPRVGSSHPQLSESINSSFASPRSQNPMVEYLDEFGRSHRVPRSDVPAGTALPSTVPSQVSPADQVYYGDQQHFPVYEPDPEKLAAIARENQRSRGALVDRYDPTKEKRTRGAGFIALGMDDNTRRKRMESLKEIRREGVQAREALESVGGVKGKREADKEERKRRLRHKRDEVQAKRNKLTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHB9</accession>
    <name>A0A2X0MHB9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C009g05471 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C009g05471</name>
        <name evidence="3" type="ORF">BQ5605_C009G05471</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY81149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHB9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="209"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY81149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="516" mass="57629" checksum="13C792E8C04DC9EA" modified="2018-09-12" version="1">MYSTQKLPLSPRHSVMSHAQLGETRCSDEPRAPLSSASTSQHNRQLPDHSDASESTHLRRVSRVTRLSGRFCSPVIYCTEANGYLSTFLARLLSLSDRELGVISSLFDRAGPASFSFASSELPSRVPCFQKHFSGSPRLEDIRIFETLFQSNSIFGRHTSAFRVSAGREGSTALTEYAMTVSFVEESRCDEHDRIRLTIANASPDDRQGLTHIVDVYRESDFVVVPRFFPDTLDASEWGLKPRALEVTFHEQCFEPICVVDSTEALARVILGAVQDSLYRLRILHRDVSAPNVMVTSDGNGVLIDYDTAVFMDGPEGEAERKKNAGTLTFRARELVKEYEGRPPFFHEPWHDIESLVYVIMYTVLIMPSGPDDSSELSEDLFLAPWGAKQWFEPFKEFWKEDLRALVQTVAKYCGLGVQRRLWAAEVDEAAVLEPRWASGELSHRQLASDLHALIARDRALLMVQGDTCWSSGPQKGSETGSDSGAVRYRQLEQQHPHLGASNVSVSAESAFKVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJA3</accession>
    <name>A0A2X0MJA3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C029g10693 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C029g10693</name>
        <name evidence="1" type="ORF">BQ5605_C029G10693</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ15694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJA3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ15694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="69" mass="7640" checksum="E43FD208B4EF339C" modified="2018-09-12" version="1">MIVKQSQIQKMLRWLINESKNSAHSAVSFDGDCTARSTQFRPGCAQPDLSKLKKMVDRLCSKSAGPISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJM3</accession>
    <name>A0A2X0MJM3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C020g09109 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C020g09109</name>
        <name evidence="8" type="ORF">BQ5605_C020G09109</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000082">
        <property type="protein sequence ID" value="SGZ17274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJM3"/>
    <dbReference type="STRING" id="796604.A0A2X0MJM3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051987">
        <property type="entry name" value="Sigma-2_receptor-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204:SF1">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="7">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGZ17274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="114" mass="13153" checksum="71065D10C507461F" modified="2018-09-12" version="1">MFSWFQSFIILEIIFQVPVFVLGIRGLLRKNTTAIHPLLAIYGASSSTTTWACLATVLNEPHLPTLNHRLTLFFTYLPFLLVPLAMTVDYTVRLTRVCREVDRGAWARQERKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKN4</accession>
    <name>A0A2X0MKN4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C022g09441 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C022g09441</name>
        <name evidence="2" type="ORF">BQ5605_C022G09441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arylamine N-acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MKN4"/>
    <dbReference type="STRING" id="796604.A0A2X0MKN4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2140.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001447">
        <property type="entry name" value="Arylamine_N-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053710">
        <property type="entry name" value="Arylamine_NAT_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786:SF0">
        <property type="entry name" value="ARYLAMINE N-ACETYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786">
        <property type="entry name" value="N-HYDROXYARYLAMINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00797">
        <property type="entry name" value="Acetyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ22170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="366" mass="40792" checksum="353896FFAD81CE55" modified="2018-09-12" version="1">MASTSLTKPTSRRPATSLFIGKTSPRIQHAILSLPDTESLLSRLDLPTTLADSEPSLELLSQILMAWHTHIPYDTSSLHVKRTDWENAMEESRSIVLGTGDGMELSVGNFERISKRYTGGYCYAQNTLCAAFLRGFGYRVTEVGARVYLFRGKDPAIVGYDWSCITHELLVDWAGSSSKRYVLDARFGGGGCPYPIVLEDGATSRSLTRNESFLLRKQTMGINSFEEIHDPPSGWTLYRRVLPRGSVVEDATSLDPSPGFWSPCVHFTLESILPSDVIMAEYYNSHASAATFMIFFVVSILLPTGARKTLSYGAPPIDLKDSDDNLIKAKLYTKEGIKGEEENVEFIPFETGPIRKVLEREFGFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLF3</accession>
    <name>A0A2X0MLF3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C023g09703</name>
        <name evidence="8" type="ORF">BQ5605_C023G09703</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ24099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MLF3"/>
    <dbReference type="STRING" id="796604.A0A2X0MLF3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF113">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015799830" description="Carboxypeptidase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGZ24099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="497" mass="54780" checksum="DD6AE0AE33D9B540" modified="2018-09-12" version="1">MMWSTLLIPITATLAATAAVHAPTSSAAVGTNSSLDHSKGSEKIAKGDISNGMTFQFTSHPDFPNHKLRIKESQLCGDKDEIYLGYLDIAEHTHLFFAFAESRDKPDEDSVLLWLNGGPGCSSMAGFLLENGPCLVTNGGNSSTFNPYSWNSNANMIFLDSPVKVGFSNARKPVDTSRKTAEDIYAFMQLFYQVFPRFAMLDFILAGESYAGMYIPQVASVIVQKNKLVDGASSNTIYVPLVSMAIGNGFVEIVSALSAEVDFACGKGVHKAIYNSSTCDALYSQAKICGDLVATCRQEPTQQTCFQAENACLKLGQPWEYGELNPYDVSKECDRSLSKDGPFCYKEAFWILAYLNRPEIRAELGLDDKVKPFELCSTSVYKAFAQNGDWVVNTPAPLSELLEAGIKLLLYVGVNDYVCNFLANRYWITAMQWSGRQQYVNAPFREFILPDGKVVGMTKSSGPLTYLEVEGAGHLVPHDKPDEALKMINIWIREGHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLJ8</accession>
    <name>A0A2X0MLJ8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C030g10747 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C030g10747</name>
        <name evidence="2" type="ORF">BQ5605_C030G10747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000069">
        <property type="protein sequence ID" value="SGZ07877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MLJ8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ07877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="191" mass="21633" checksum="0A15A20597BE8BAA" modified="2018-09-12" version="1">MRDDFKVFTIEPRSSVPPGATIVTSKFVWKTKRNASGEVTGRKARLVAQGNRQRDGIDFSEMFAPVARFSSIRCLLALAATNGYHVHQADIDKAYLHGELDHDIWMTTPRGFDFPSDQVLRLRRSIYGLKQAGYKATGTDHCIYSRIDDQQRPHYIALYVDDLLIVSPGLDEIKCVISGLEQRYGIKRNLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLW0</accession>
    <name>A0A2X0MLW0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MICOS complex subunit MIC10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C028g10459</name>
        <name evidence="10" type="ORF">BQ5605_C028G10459</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 9">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Mitochondrion inner membrane</location>
            <topology evidence="2 9">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the MICOS complex subunit Mic10 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000080">
        <property type="protein sequence ID" value="SGZ11809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MLW0"/>
    <dbReference type="STRING" id="796604.A0A2X0MLW0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007512">
        <property type="entry name" value="Mic10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21304">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21304:SF0">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04418">
        <property type="entry name" value="DUF543"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGZ11809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="201" mass="21188" checksum="C0FED740C1A71EA0" modified="2018-09-12" version="1">MSSAPAPSNKTSSAVPSENVLSAKASARRGMSRTSWSYPNPIASPCYSSTDGCSFLDLPTDRNPYTVLVTNSDICVSNAIVKAGIGFGAGVVCSAILFRRRPWPVFVGLGFGLGQGYSDCERVFNPAAVPGFVIAKDGKPQASPYANFNPFGSKASDVKDSAEDKVSQVVDKVKDATKQVVGKAEAVKDKAENKLGDTKWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNB2</accession>
    <name>A0A2X0MNB2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C003g02267 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C003g02267</name>
        <name evidence="3" type="ORF">BQ5605_C003G02267</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MNB2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016169364" evidence="2">
        <location>
            <begin position="29"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY39715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="366" mass="37754" checksum="5FCD88680DEE3F07" modified="2018-09-12" version="1">MIGVARTVVSTGALLAFLAASAIPTTFANPEPRPPGPPKPLNLNDLASLSLTPQQALDAETIASDAAVSNSLGPHANPPRPNDSASQWGKIQIVSTDSSSSTQWLGDGSLDGSGVYANTTDQPGTVNFPATTCSTLPPLFSIYGILAEYAALPYIGLASFTGLPNAPSSLSSTSGGYAFVAPVNQTNSKTFAQSESSLGSPYRGESAVWSLDCITQELTASWTLSDGSSLPVSFVSWSKSGLVATGNYAAFKQAFPTAEAPLKFVFVPAANGSTTFWDAQTAQDKVVAATTAAARTTRSTRSARPTRTPRVRTTASVVPSIAKQVGQNVHGIAAASQRLGSLSSTSPISSSSPGAKSGIKHRRHQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPW9</accession>
    <name>A0A2X0MPW9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C016g08039 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C016g08039</name>
        <name evidence="3" type="ORF">BQ5605_C016G08039</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY20402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MPW9"/>
    <dbReference type="STRING" id="796604.A0A2X0MPW9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF118">
        <property type="entry name" value="BETA-1,2-XYLOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="2">
        <location>
            <begin position="393"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY20402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="688" mass="78936" checksum="7908338ACE6900C4" modified="2018-09-12" version="1">MNGIRPGEDPYETVSLLVVAPDTPLLGSPGRRVRHIARMGRGRVLCCRPRFLITLMLVSILTLLLLPAKHRSAAHNVLTHAGVSLPDALPDRIHDFIETWANRADDGSKDLVYTPHLSPGPEDDDSTWTVTTPHEFNSNGHLIVEPVSTFGKAPPAPHPILTLIQRAEHEWNNRVQRQSKTLREAVYEYRKRYRRNPPKGFDEWWAYAKANRIVLTDEYDQIFKDLQPFWALEPHDLKHRVLVMQEREETFTIQVKDGEVFELGEQAQLKRAKDFRELIARVSKHVPNVNLTFTRHDQPACQLGWFHKERMLELAGEGEHFGPSEFIAESDLPLTNWANGCPPDSPLRKIETEVLEAAGQPADKASIQAKLRKAYATELSQKRSYIYDYSSALDICQHPEIMPLHGFTTAIGTNPGPLVPLFTFAKTNIHSDILVTPLEQYSDTYIGYDPDWEKKEYNKLMWRGSTTGAEFAVGYDWRSSQRARLHFLTNDLKGQKNVLISEEEGPIKEEMMQMHNLNKAQCDVSFSGGPVQCDDETCAIMKEEIEFRPTMGLTDSYKYKYVFDVDGNGWSGRFHRLMSMKACVFKSTLFPEWYGDRIQPWVHYVPIKVDYSDLYDALTFFRGAPDGTGAHDELGKKIGLQGKEWARDHWRKQDMAAYMFRLTLEWARIVHRADENVDPASLDFEFFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MRD9</accession>
    <name>A0A2X0MRD9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C027g10345 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C027g10345</name>
        <name evidence="2" type="ORF">BQ5605_C027G10345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MRD9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ28462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="419" mass="46374" checksum="03128054DFD15B05" modified="2018-09-12" version="1">MTRPPALDSNADSDPAVDDSEASSSDGDEEAMDRLRQVVNLLENCAPNHLQLEYDTMQAKRQAIMSSNLLWSAEENADYGQWSLILGDRRKADEWTLKDTIPILKLPLYMATEEHEWTACKYERCLAVIETSHGAPLISFHQHPADHLTFVDDPNIPSPEQNFANCLKNIVPFLTARAEGPIPRVTGGSDRPTIPYAEWERVIVKPRVPKKGDLMPRTEFTRQPDGNACGVFVCRTMETLVAAVAFQSELDWSWSPLKPLQDNFMLTNAHTCYTCGAPPPVPELEEKPLGSPGIEISPPTLILIDPSIGTMYTSESNTDAQCIAPLISRSPRPNPAPSIATIGSMPDAPPPMRLQRVVRFDPTPPLPVSEALEVIACLPRYQTCTLAVRSIAAISTNAPSPRRSKRKREASFFQAARLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MRG3</accession>
    <name>A0A2X0MRG3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C026g10195 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C026g10195</name>
        <name evidence="2" type="ORF">BQ5605_C026G10195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ27814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MRG3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ27814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="219" mass="23480" checksum="842A821753C8CA50" modified="2018-09-12" version="1">MVEQGGNNPGGTGDAAGLPNTALPLAIVKSCGPHKFPKTRREAAHQEGGMYQRMSAHSLERTRGRQETLRPNANDTTSSARNCSKIQSPKFVYDVKALRDNARIIVQRGALLRKADFRSPSSKLKLLGRPGSDHPIAACRRAELQAGGRAMLTGGLGTRAPTSTASEVTMAELSAPAVLVDAHAVRRSRLLKGQNSLDNTGHHNRSFIVLLHMHPALGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MSH9</accession>
    <name>A0A2X0MSH9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C048g12349 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C048g12349</name>
        <name evidence="2" type="ORF">BQ5605_C048G12349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000110">
        <property type="protein sequence ID" value="SGZ30402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MSH9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ30402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="366" mass="39795" checksum="2878BBD2D1CEF8A6" modified="2018-09-12" version="1">MPDPPGAQAPPPDNPLGGNRASDDESLNTLTREPVTGGTANPPAWSTEATQARLDCEKVMQNTFRVLGIVPSGKSTRRLMVLMHDASTPPSQAPLLARAAQRAVRNDAAPASNVIRVIMDGPGSPRGPVQIALRKHFGLAETPFMFARPEGVVLDPEVEKLFSKCVKLNPIVTKATKRFPIARHMYELVFESDQACLEAAAAGPFSHHGKEMVTELPSASPLNHVVQVRFTLPSSSSATPASVLRQSLDDALTLSFGRAGRTQGYTLMQLQRGLAVDPNGDPMAMTEDGFHCAYLRLHADLFQGSTETQKAALNAALPQEIEILGAKYGLRHEFETHYCAVCDRAGHQWGACRYDVKQRTDLLKQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MSZ5</accession>
    <name>A0A2X0MSZ5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g04048 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g04048</name>
        <name evidence="2" type="ORF">BQ5605_C006G04048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY55588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MSZ5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="392"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY55588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="418" mass="47828" checksum="D155ECC6494229DC" modified="2018-09-12" version="1">MAPRATEGERAWLDIDSHLIRDESGQWRVRCELCNKHYKLPGGYRSLDGPTVAPEHAHEAKRNLKKKHSRYRCNEAAFELIGTDCEVQAGFGHLKKRYRRQLQAKLDMLEAPGKADRARHDEWAAERARRLAMEPKDIMTQDPIPEGVENFDYEVREEIDYVMWPVWDEWAGYKGNGRLPRSLLTVLIHWRNVLFDAYDNQKRKRGGGSARVLKEYRTRIQDFDDILARIFTVPVDIAAEHEESRLFSEILSPLYQECQRPLPEDDAYRPFLGKRVPDDYRDHLESEHRTWQAALRPFATTVLVHVPEPPKPPTDADLEPERKKIWDSWIVECAHMWLALSSKQRDAYCWMRKKGSGGEGAASTSGAREEDAISEHSSATGQHSDHGSAAGSEAESNLSTLSELTSLSELERGLDTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MU54</accession>
    <name>A0A2X0MU54_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C040g11865 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C040g11865</name>
        <name evidence="7" type="ORF">BQ5605_C040G11865</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000118">
        <property type="protein sequence ID" value="SGZ32377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MU54"/>
    <dbReference type="STRING" id="796604.A0A2X0MU54"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF4">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="13"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="179"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="6">
        <location>
            <begin position="473"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGZ32377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="683" mass="75669" checksum="6B571D6525E3E3BA" modified="2018-09-12" version="1">MTAASVPVPQEQYDVVIVGAGPAGLMAALCLTTYGFQVLHIDDRSEPTTAGRADGLQPRTLEVLRNIGSVKGKTPGKAGLAKRMIADGVRVYEVAFWDPTETEQLARTSRAPSCPEFIDVVDNYTLLLHQGLIENAFLDEIENRRAHLPSDKFVPAPHGGCFRPYLFETCSTDLEANSEYPVSCTMSHADTKEKYTVRAKYLFGNDGARSLVRRAISGGEVGDGEWQGKIRMLGDASEFIWGVMDVEIKTDFPDIMSKCLIHSKDAGSIMVIPRENGLVRLYVQLQEEGTGKHYDRTAATEDICKARAAKIFQPYKIEWGRTDWFSVYQIGQRIASAYTLDERIFLGGDATHTHSPKAGQGMNISLLDMYSLSWRVNLVEKGMADRKILLPTYEIERRGIAEELLAFDRAYATLFSGKSPKSDQLTADATKAKAKGAVDAELFIETFKKNAFFTSGCGAVYGSNSILNALPDSPLVQNYAKKGVFNPEGTELIAGRRLLPGKLTRAVDANQVRIQQEVKMNGAFRVIVMAGQYEASKASLKAFDEFLSSSSSFWNVHRPKQGIQAAQVYNSYDSRHIETDTRDPNFNPFFTFITVFADPHTEWDIEALPFNLRAYRDQIYSDDIFDKRVPEAGSNAPLHAKYGVDVKKGSIVVVRPDGYVGAITSLDADGFEALNAYFKTFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MX79</accession>
    <name>A0A2X0MX79_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00254 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00254</name>
        <name evidence="2" type="ORF">BQ5605_C001G00254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY45157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MX79"/>
    <dbReference type="STRING" id="796604.A0A2X0MX79"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY45157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="348" mass="40007" checksum="EBEBB7F534AAB35D" modified="2018-09-12" version="1">MGYHWLPWACSSARCWAPRGSTLLFVPLRSTESAPRRVMTTSQPILALRHVYEPAVQLCRTDSGFWQHSKEPALRHEHVWARVGQKLKAKALLPKTAVRPARIPLKEDPHPRCFNFFGLTRPFTIRKLRRLVNTVRFPGKDGQDRALPGGQPQEPRVKRFPEGTSQSGRQRFWSWLHDRFASAAEQDTHWRLMYDVTPTRKKQHVQGHASSPSCLFCGNDAAVIETVSHYFFGCAYSASYWSGVLRILFDKLGIEDTDVDPSTFTQEQLTMGLPLLRGRGRTTSKWMWVRLACAIGFQRLHLLRWHVHQRFEKDRVVAPPSIPSALRAFKRDFLSRAGFVPGARDWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N118</accession>
    <name>A0A2X0N118_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C009g05776 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C009g05776</name>
        <name evidence="1" type="ORF">BQ5605_C009G05776</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY85774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N118"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY85774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="102" mass="11034" checksum="8242B688DD24C993" modified="2018-09-12" version="1">MCLTASTVRLSSRVPGIGSSLSCGGRDIVASFEPSFSTRVCASPTMSLPPHNKDDPIPGTLELRRTVDAVKHIRDAFQDGARILTCGVRVAQAPLRKTRDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N1H0</accession>
    <name>A0A2X0N1H0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C039g11820 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C039g11820</name>
        <name evidence="1" type="ORF">BQ5605_C039G11820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000060">
        <property type="protein sequence ID" value="SGY90655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N1H0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY90655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="110" mass="12262" checksum="1A83E7377427AB6B" modified="2018-09-12" version="1">MAGDRSLDDAFDRLRCERPFSAGRRTINQLQHATSRSLLNAKMCVGSWADAVADDDAARKELIDRVTVIFTPIVRLSYSAQPPKVVPGNRRATGTRETITSMMMMCRSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N4R1</accession>
    <name>A0A2X0N4R1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">mRNA export factor GLE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nucleoporin GLE1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C005g03456</name>
        <name evidence="12" type="ORF">BQ5605_C005G03456</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GLE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY75898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N4R1"/>
    <dbReference type="STRING" id="796604.A0A2X0N4R1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.510">
        <property type="entry name" value="GLE1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012476">
        <property type="entry name" value="GLE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038506">
        <property type="entry name" value="GLE1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960">
        <property type="entry name" value="GLE-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960:SF0">
        <property type="entry name" value="MRNA EXPORT FACTOR GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07817">
        <property type="entry name" value="GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="76"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="329"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY75898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="733" mass="82011" checksum="E2956D11624C009A" modified="2018-09-12" version="1">MKFGLEASSSSCASGSESEHDDTRVTISSVRRPQPLITRGDDDDDSDAPVPLERLASRSAEPFCFWLVPIRKAPFRRRPPTAGLSNPTSSTSTLTFAQTASSTTTLAASPSNFIPRPIRTVAPPSVKSRKGRLVQFDSNSSDEDLDQSSWRRRDTRPRPDYLVDEDEDNDQDQDDDRDDDEYSDSEEDQWPVGPIGSVGIGGWRRANGDTSSARGAKARSSRIAMSPDHHLKAYGGTDAFQIWDDRSKAISWASANRSFHLSLARSFSTSPTASRTHSPSTSITNDISSIESRLSSLALQASAEKAALVKSFQTRNAALWDSIEASIREAEKEEGDKQRVLEENRRKRQEAERKAKEMREAEERKKKEEKERKIKEGEERERKEAEERKRRKEVEEKRVKEQEDRDKKLAIIAPPSGKGIEGSPQAEWERWTAVMTQIKTGVLPVVSQNPTYRKECFTAKRAITPKIGQLTASAEMTLRVINQLDQVLSSMRPPPGGPREPYRWTLNHLAKALVKQAETEVTARISTAYPLARVVIGLIVRGHQELGEVLMARLVKKCFWITGWWPPKQPGQTEEAHQKYLGHAPPSAGESLIQYASRMSGLIALYAAITQTSPLEAPQGPCPHEQVAHVPPHFRLAAGWRWIVLILRVPLVGLQPTPQLLGSFLEIAGERLLEVYGKQFAKILEVLLREGIREGKAGFSDKSVSSTVRLTLWLEEWEKKGKVEITQGRKPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N7V2</accession>
    <name>A0A2X0N7V2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BQ5605_C009g05778 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C009g05778</name>
        <name evidence="12" type="ORF">BQ5605_C009G05778</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY85798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N7V2"/>
    <dbReference type="STRING" id="796604.A0A2X0N7V2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HTH myb-type" evidence="11">
        <location>
            <begin position="165"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="9">
        <location>
            <begin position="165"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="474"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="502"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="199"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="402"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="647"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="812"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="277"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="417"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="658"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="702"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="741"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="852"/>
            <end position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY85798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="869" mass="88529" checksum="666311032164F45A" modified="2018-09-12" version="1">MSGSPAATSADDARALANNAVTSELRTDPASTAAGKELSTSTKTNSAVDANQSGANSEEDAPFEPDTDPIPTSTTAGAAIHSGSATKGVETESNERGTSVTTAAPTHSVPGVSASTSTFAPPAPAPVQASPSTLNVSESIAGSRPRRVSVLSTQPDTSDQRSVVKWTPADDRKLDEAFAKYGPSWDAVAAAVGNGRTNRSCKERLGRRQRSNDPTVSMAPLTVVPRRASIDAGEGDSPGHEHVFNRRPSPFADAEGEDDSMVVDAPAPPAPAPAPAPVVAKPAPVATPVTSDTPPKIIGKKLGKSRPSAAKLVPTAAPSAATTSAATAAPVPAPAAAVEVPSTSTAPPPAVDNPLVYSAATADRTMVAGGVSATTARILSAVDDRLREAGIGGRIPGRVVTAPANGDVKPELTSEDASSSPSTSTPTLAPSAGHNIALTTPFNKNTVIRGRRTMAANEMEGKLLSKTGKIKKVHICPADSCDAAFKRSEHLKRHYKAVHIAFPCDAEGCDKTFSRKDNLHQHMIFVHSLKPIREDGIQFLDELMPPAAPVPAAIPEVAVAASPNAPVAATSVTLGHSVLAPTASISAAPMTPAAVEGSQSPAAVPAALSNTGQFASSRGRVPVPIRYEPIAEEDKNRRRKIVRKMSPGGTFTEEHLNSPGPGAAASPSPLAADAKPKTEPIEQSLSTKAASPAPQAAKETKVAAVSPPVSPVAPEVASTSSSTPPVLPSASTSTPLEEEATTNLTRTPSTSSRAKPVRGGGLGARFRQGRGGSIAAAASAIAAAGATSSPTTTKRPAQVPVHCTPVIEVTNGHAARPRENVVEEPSNEGGALGFAPPRKHAREESGNVDEASAAKRARDIELDSGNVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NAD0</accession>
    <name>A0A2X0NAD0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C051g12539 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C051g12539</name>
        <name evidence="2" type="ORF">BQ5605_C051G12539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000096">
        <property type="protein sequence ID" value="SGZ29567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NAD0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="386"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ29567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="412" mass="47439" checksum="3D12560EA7D0940F" modified="2018-09-12" version="1">MAPRATEGERAWLDIDSHLIDLIRDESGQWRVRCELCNKHYKLPGGYRSLDGPTRAFNSSTVDSRYRCNEAAFELIGTDREVQAKRYRRQLQAKLDMLEAPGKADRARHDEWAAERARRLVMEPKDIMTQDPIPEDVENFDYQVREEIDYVMWPVWDEWAGYKGNGRLPRSLLTVLIHWRNVLLDAYDNQKRKRGGGSARVLKEYRPRIQDFDDILARIFTVPVDIAAEHEELRLFSEILSPLYQETRKGSYRLLRWIRKVYRPFLGKRVPDDYRDQLESEHRTWQAALRPFATTVLVHVPEPPKPPTDADLEPERKKIWDSWIVECAHMWLALSSKQRDAYCWMRKKGSGGEGAASTSGAREEDAISEHSSATGQHSDHGSAAGSEAESNLSTLSELTSLSELERGLDTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NBC8</accession>
    <name>A0A2X0NBC8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C028g10496 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C028g10496</name>
        <name evidence="3" type="ORF">BQ5605_C028G10496</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000080">
        <property type="protein sequence ID" value="SGZ12328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NBC8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016040999" evidence="2">
        <location>
            <begin position="22"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ12328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="165" mass="17503" checksum="9AA25E648D18787E" modified="2018-09-12" version="1">MISSRRHAILVLLVCITVTSGAPTPDPLSLGGFGKLLNPFSWFGHKNSSDGTTTSGTSANTSTASTSHPEDTARNAAAVALEKADPLNNTRVCAVACAQKENGITKNRLCPQLCKMTMNLRKAPQASELLLPFALGTEDEAHVFRRGRTFYLPRGISSDATATIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NC93</accession>
    <name>A0A2X0NC93_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C040g11859 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C040g11859</name>
        <name evidence="6" type="ORF">BQ5605_C040G11859</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NARF family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000118">
        <property type="protein sequence ID" value="SGZ32342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NC93"/>
    <dbReference type="STRING" id="796604.A0A2X0NC93"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.950.10">
        <property type="entry name" value="Fe-only Hydrogenase (Larger Subunit), Chain L, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050340">
        <property type="entry name" value="Cytosolic_Fe-S_CAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11615">
        <property type="entry name" value="NITRATE, FORMATE, IRON DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="Fe-only hydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iron hydrogenase large subunit C-terminal" evidence="5">
        <location>
            <begin position="146"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGZ32342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="656" mass="71622" checksum="296427DC3740469D" modified="2018-09-12" version="1">MSLSAGLTLTDLNDYLAPSQLCIKPVEMVEDTDPDEEESSKLANDPASKANVSQNRFVGLIGMSCLLTDPDDRAKMEIMIDPSTLAYYEKASNGTKVKKLKKAEITLNDCLACSGCITSAESVLVQIQSHQEVERMIKERPDLTPIMSISPQSIASLAALHDLSLEDTIKGLRLYFKRQLGFRFVFDTTFARSISLLENRLEFLERRTHAEQNPAKPSPSVLSTSTNSPTSSSTGPLPILSSACPGWICYAEKTHGELLPFVSNVKSPQAMMGTLVKGGRVAKRLGLKPDEIYHVSVMPCYDKKLEASRPDFATPFVLDPSSSSTKAPTSPVRDVDCVLTTGEVNTMITASGTTLSRLAKESNDLGASESEYFPSTLLSPRSSDPSTSTSSGGYFQNAILAILSNLPPETYPELHVDLKRLRNDNSVQSTLYRKDQVLVKVAKSYGLHNLHTIVKKLGREFGISVSVGAAGRAPPSMRGASGYGSKTKVGLGKEKERDLEFIEVMACPSGCVNGGGQIPTPSNSAAARRWEVDQEGMPDVALTEMKEEETGGMDLDGGEEDRKVLSSVEWVNKVEQKYWSVYSTTPASPSDKEANLDPSIVPYIRNLRGIQEEENEVRACLEELVEGGGIERRKELLRTSYRALEKEETNGLAVVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NCY1</accession>
    <name>A0A2X0NCY1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C069g12862 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C069g12862</name>
        <name evidence="4" type="ORF">BQ5605_C069G12862</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000131">
        <property type="protein sequence ID" value="SGZ35090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NCY1"/>
    <dbReference type="STRING" id="796604.A0A2X0NCY1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000795">
        <property type="term" value="C:synaptonemal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019789">
        <property type="term" value="F:SUMO transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042123">
        <property type="entry name" value="Zip3/RNF212-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22663">
        <property type="entry name" value="RING FINGER PROTEIN NARYA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22663:SF17">
        <property type="entry name" value="RING FINGER PROTEIN NARYA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="213"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="258"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="425"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="175"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="213"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="331"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ35090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="465" mass="51259" checksum="81211ACFB91A49A4" modified="2018-09-12" version="1">MQARAADRPEGISSRASGSVRSGHFQHGIINGTGGSTLAHPPLEWVACLGCLKSHPVLLPFTEPWDNLYITTCCHVLCARCAFSGHASEIATATASAHHQPAPSDPPSTATLETLSLSCAICSLDTQFMLLDENVPDELAPCFRPLVRTLEELSAATNWQVDHLALQVAWLRHKCERQKGNLTKLVQELKRIKGELGKFRELEQENERLRALVDSREPRHEHEFRLPHRPMGLHPPSDPRYDHLTLHEAQPDHAITRREAPDNPARPSSVAALPAAPSRYSLPGTLKKQSHEWPGPRSRTSSIAARSPPQRSASVSTKSPRQRPYPRPQASPHQTLATRPASAQPTARMSPWRHPAATPPPPRASTAQGNRQHFEPLHAAQYRARQEQAGLGKIDEENTGLRATEPQSGSVILPHIETGTVRVSTPRQPFVPCPASASRRTGYEDTRGQSLPRGFQTARDLHRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NFL1</accession>
    <name>A0A2X0NFL1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C026g10201 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C026g10201</name>
        <name evidence="1" type="ORF">BQ5605_C026G10201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ27832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NFL1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ27832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="310" mass="34957" checksum="8E246D012293177D" modified="2018-09-12" version="1">MAVCIHYKARHWEYERSKSTGHYSTCCLQGKVQLPLLSGPIPNIEIYLKDSGHIPRKRPVAQQRAVFHFDQTRIGTLGLPVFRVFGRLYNRLGALIPAVNQRPAFAQTWLIDPAEATDTLLGPDSPDSRIQRSTLTKLEFNTEMAILIPTPIREIVDRKIVFPRCTVIDVPMVGPSTKCLARSIRLGCLSGTHYSSPRGKMASTPAFLFSVRSSWATLRQKTATKKVRTRRKGTKRTVMARAQTDIECLNTYDEGQVKGVKVVSLAFTNPLRFTCTNATSPHGTRRPFPAFVIERYSQAETDRLNYIQLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NQU4</accession>
    <name>A0A2X0NQU4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cofilin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Actin-depolymerizing factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C015g07901</name>
        <name evidence="7" type="ORF">BQ5605_C015G07901</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
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        <property type="protein sequence ID" value="SGY17815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NQU4"/>
    <dbReference type="STRING" id="796604.A0A2X0NQU4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11286">
        <property type="entry name" value="ADF_cofilin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11913">
        <property type="entry name" value="COFILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="6">
        <location>
            <begin position="24"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY17815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="161" mass="18045" checksum="3809A180E16B02EF" modified="2018-09-12" version="1">MKRRLTSSSVIKQPWIRLPTGSWSSGVAVNAQCVETFTTLKLGKKLKYIVFKLADDNKEITVEKSSDSASYDDFVADLPADSCRYAIYDFEYEKPAEGKRNKICFFAWSPDDAKVKNKMLYASSKDALRRALVGIASEIQGTDYSEIAYTEVLEKVSRGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NRH4</accession>
    <name>A0A2X0NRH4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C011g06318 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C011g06318</name>
        <name evidence="2" type="ORF">BQ5605_C011G06318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY11913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NRH4"/>
    <dbReference type="STRING" id="796604.A0A2X0NRH4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY11913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="158" mass="17645" checksum="01A1C782A56AB656" modified="2018-09-12" version="1">MGLLKLARAPAAEPAARLSSFSRSDQPNQLPARDDNHSTDLGITTRISRQVRRPRIALKPLKPHVSIRDGLGPQTAVCTHCKARHWECERSKSTRHFSACCSQGKVRLPPPPQPNLEYRQLLQGSDSETVAFRENARSYNKLNALSSLRSLPTLTRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NT62</accession>
    <name>A0A2X0NT62_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C016g08196 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C016g08196</name>
        <name evidence="2" type="ORF">BQ5605_C016G08196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY21104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NT62"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="676"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="823"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="517"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="628"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="676"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="687"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY21104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="883" mass="93720" checksum="F8D3B2F0FC48615A" modified="2018-09-12" version="1">MAATANSSTSSGSTSRTSMFKSKITKAAQAVRNLSQQPVTTSVPEELRSKPHDTPPSYTTSPESPAGLAFRRARSADAGVTSTVTPKSPRAETRTSPRPNDEARQNSFRRAKANSASFRLAIAGNGVPPSPPMPEPVFNVLSIQGLKDYAPGPGLDNTGFTARAQTPDEDVPMIREWRYKDSYLPRTSLGPSFTVPALDGLGLVGFGEEDIVMSDTTAQAHTARMARSSSADTPTQQGDSLSNKSVTSESKNVAGLTRPRARLNRTSSSSLHTLEIKLASASFRLSAADAVALAASQPLAESASPRKTSVPDFQSKVAEYRRRETNQLNPTSRLGAMGPALVAERRRTVAGDPRSLRLSMNRAALRESLYKPLPSKPTMQAPSLRGAPSGYCIRPSVSTATQTPSWWPSSTYAPSASSSAKSVNTDNTVPSTSSMPRSAVHKWSNTPPQAYSSFPISDLALLATPANLEAFPSPSLYSVADTAASPPLPRLPVEAWNSLTLQYEPEPQPVQMSSSGPRNMSRRTSTSSNSPTLHSPSLMSSARLVSPAIVTPNVKAEFVPAPSSSAEPRLTPNQAEHTSSAEKDNEVPIPAAVPRPEARHSLRSTRATSMYASQGTRSSMASNGKRGSLPSESLSWSESRPYVRARPVSVFNPLYQPSVPFQPQKKLAPIDHDTLASGDRLRERRLSSVSRLSSASLGKPERRLSGMDGSDEYSTAHNWPPLGDSGGSLMRFSASFAAAPIAQPTESGPEDNIGPKTLAPPSARVTSPPVFSSPIIIPATPIPASTSSIPSVPHDDDDADDGELLLVAPIARRASSLSVDIAATRRYSSSTTPPPRPTPSPLRISSLSASPDTLTVRRKSFGPPVNPPSPMRRSPSPAVGVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NTC6</accession>
    <name>A0A2X0NTC6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BQ5605_C010g06075 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C010g06075</name>
        <name evidence="12" type="ORF">BQ5605_C010G06075</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mis12 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NTC6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008685">
        <property type="entry name" value="Centromere_Mis12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14527">
        <property type="entry name" value="PROTEIN MIS12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14527:SF2">
        <property type="entry name" value="PROTEIN MIS12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05859">
        <property type="entry name" value="Mis12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="260"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY14134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="297" mass="32682" checksum="2EDC58EBF4C0585F" modified="2018-09-12" version="1">MATEYIPPLTSLSAAEQRSIKSSLLTEHFQFPPETFARNGMDLANQTIYAATKIVEDSLMTMTRLPEEEGDERPFVFEGDDVQKGVYRLETLLEAAVDKYFDLFELFALRNSFNLPSELIPYIVLFHQERLDDALLGQDRSAIEEYEHELASYEQTLQKERALKCVEELGQRKLDRINAIANEVGQMSSAEPMSTRIEQLSSQLPQLHQTLSVLLETPSPSLGSALPSSTTTTNAHEPWSESRSAFVNWATKAKIDALPSSSTLTGAGSSGSTGDSALEGLRRGMQETGGGGEALVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NTJ1</accession>
    <name>A0A2X0NTJ1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C010g06145 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C010g06145</name>
        <name evidence="2" type="ORF">BQ5605_C010G06145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NTJ1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY14337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="75" mass="8217" checksum="B3318638D89D63FF" modified="2018-09-12" version="1">MIDAGPFVQVQWSTTPPHNRRQIGGKHYHCTHSPSSRLHEQPSSLPHRGSSARSATDDLIVQANQRSQSTASTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NVM2</accession>
    <name>A0A2X0NVM2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Imidazole glycerol phosphate synthase hisHF</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="9">Glutaminase</fullName>
                <ecNumber evidence="9">3.5.1.2</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="9">Cyclase</fullName>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="15" type="primary">BQ5605_C012g06970</name>
        <name evidence="15" type="ORF">BQ5605_C012G06970</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="9"/>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NVM2"/>
    <dbReference type="STRING" id="796604.A0A2X0NVM2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01748">
        <property type="entry name" value="GATase1_IGP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04731">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000039">
        <property type="entry name" value="Imidazole glycerol phosphate synthase hisHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00278">
        <property type="entry name" value="HisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004651">
        <property type="entry name" value="HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050064">
        <property type="entry name" value="IGPS_HisA/HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014640">
        <property type="entry name" value="IGPS_HisHF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010139">
        <property type="entry name" value="Imidazole-glycPsynth_HisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01855">
        <property type="entry name" value="IMP_synth_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21235:SF2">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE HISHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21235">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISF/H IGP SYNTHASE SUBUNIT HISF/H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036936">
        <property type="entry name" value="IGPS_HisHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51274">
        <property type="entry name" value="GATASE_COBBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 9 12" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="14">
        <location>
            <begin position="4"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="260"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="11">
        <location>
            <begin position="387"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="11">
        <location>
            <begin position="429"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="447"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="11">
        <location>
            <begin position="521"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="11">
        <location>
            <begin position="547"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="11">
        <location>
            <begin position="570"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="10">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="10">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="10">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="431"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="11">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="516"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR036936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR036936-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR036936-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SGY16737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="597" mass="64465" checksum="EB747429DAEDB895" modified="2018-09-12" version="1">MLYILDYGAGNVASLANSVRSLGFDFKWVETVEDIEKADRILFPGVGSFDSALRSLRDKGFAEPLKKYIASGRPYMGICIGMQALFQSSSESSSEQGLGVIPAHVGKFSPAGGKSVPCMGWNGAIPLRADRAEAFGLSGESAFYFVHSYRVEFGPDVEDWALTLTQYGDEVYVSSVQKGNVFATQFHPEKSGQAGLDVLRAWLDQGEAMVDTSGQQKRPRADVKEELVARGFTKRVVACLDVRANDQGDLVVTKGDQYDVREAEESTTTATPTPSINADEGSSSTDVPPPKPSRAVRNLGKPVDLARRYFAEGADEIAFLNITSFRSCPLHDQPMLDVVRQSAKTVFVPLTIGGGIRDTVDPDGSQRSALEVAGTYFRCGADKVSIGSDAVFAVEDLLEREAKGEEPLSGKTGIETISKAYGNQAVVVSIDPKRVYATSLDQIPQPHRKNAVDLASPQLPSKAPTTAPVKPDLGPKGEQFCWYQCTVRGGREMRDLDVVQLAQGVERLGAGELLLNSVDRDGSKAGFDLRLVDLVRSAVGIPVVASSGAGKPEDFKEVFRETRAEAALAAGIFHRKEVPIEDVKSHLKQSGVRVRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NXM2</accession>
    <name>A0A2X0NXM2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C015g07946 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C015g07946</name>
        <name evidence="7" type="ORF">BQ5605_C015G07946</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 37 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NXM2"/>
    <dbReference type="STRING" id="796604.A0A2X0NXM2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008107">
        <property type="term" value="F:galactoside 2-alpha-L-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042546">
        <property type="term" value="P:cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009969">
        <property type="term" value="P:xyloglucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004938">
        <property type="entry name" value="XG_FTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31889">
        <property type="entry name" value="FUCOSYLTRANSFERASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31889:SF2">
        <property type="entry name" value="FUCOSYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03254">
        <property type="entry name" value="XG_FTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="196"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY17992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="957" mass="105478" checksum="814A81F30E29801C" modified="2018-09-12" version="1">MSGIHLIPVPEQRRRPSLPPGSGDHLLEADPSSSMSSSSLHQGSRSPSPSPSPSLAPSPIIPHTSFGVPCSSEHGRHRSSLDGFTSPNIAAPAKRLSKMIFADPIPEDHHTDLRYGETHWSGLPSPSRSKTRFSEPSAAGAGPSEVAAFGLGASTLAPPPIDPNTYSNMIPDLSFRTESVIEFNIQPPAKEYASKAVSGAAASSDGDSASHHQSLEDTPLEPTLPRTTYVPRSTKRTPSLTTRVTDAFIGWISSPSSSPSGLSSSGSDISYDSPISTAASTPPRFRYHVFPISPSLLRPHPRLIHGATSLVTKSTRSSKKWMLLVCAALSVLLFYRRTTLSQELDHFDSLSRTELQAATAVPNSRPSRLGPLKSRLRKAAHDRFRKAPSYRTSASQLSASDEKRIETGEYDRILALNQPPRRRIFGPDDSVLNSNTGDTKRRRLPTVADLRRQFNTDKQAYMAQRKGWHEFEWRAPHVDASLRRFEATLTGDEFELKGWIRRLHRGIAATSVGLARNASQEPLPLELVEYVPELGAMPYLSRTSGSIKKWESLEFQAMSPGDGGMCAGSTWMNEYAYMHREILNGDREPRLVSYHCETGMNCGGAADRILGLTSTFLFGLVTNRAFLAEWQSPIPLEVIFDSPRIDWSHSSFSVDSHPVLGDFDLASRAKELDIVNFDRLAMDTTFRSTVWNWQEDRHSKTLKPGFEQRDLALQSPWVKMYTNRGMISRSFHYPTLQPRLQQLGLHPLTAFSCISNYLFKPKPAALDLITSYTSLMELPTVFSVGIQIRTGDESMRNPEHDKSNTVARHSDYFRCARELATTYSLPTQRILYYLVTDSAHLKTDAQRVLGEALVLTDMKPRRDHLASSHHAVDGVMGAVVENWILGKTDMRVTTQDSAFGKLAAFASGNNHSTVTLLPKDHPGRKVKAKKGGRGNLDCTTAGALVGFDELSSTGSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NYX7</accession>
    <name>A0A2X0NYX7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C016g08130 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C016g08130</name>
        <name evidence="2" type="ORF">BQ5605_C016G08130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY20707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NYX7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY20707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="63" mass="7178" checksum="30B576D1AFBFA997" modified="2018-09-12" version="1">MQYTRAAPPAEASETTMTWIRRPRPRAELESAPLCKCSAGVRWQGRTSKFVGDANGDYWFKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P0H1</accession>
    <name>A0A2X0P0H1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C001g00611 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C001g00611</name>
        <name evidence="3" type="ORF">BQ5605_C001G00611</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY48087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P0H1"/>
    <dbReference type="STRING" id="796604.A0A2X0P0H1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF26">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="149"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY48087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="415" mass="46681" checksum="727877C7D5A1BAB2" modified="2018-09-12" version="1">MTMRPAPLAIAPAPFSRQPLKAIYLTYVLISILIRQPYWILRYYLRLRVPYPRSWSLIEALGAQSMRQMPRLLTQCDLRFNVSSRIELPAKPFRRCRALWVPPASDAWMKKGSIVDDEIVKVRRCPAYVYGKDHRGLGRMQVKKGEHVLLYFHGGANLIGNASELDGTAQAVLQLLSRCSKTLQHALSVDYTKVGDLPFPAHLQDAISAYAYLVSDLGIPPSSILVGGDSAGGGVAMCLLRYLRDVMKVDEMPRATLLLSPACDLSGDLERLPEIEQSEVVKLRASQDMMNRVVYKTYMVKRLLRHHPPSLLRSPYLSPASPHFKPTPSLFKGFPRVFITCGGIETFRHSIEELASRFRLGGVETTFHLEPDAVHDYVVIPFWNKASKAKTFDLIASWVNDQIFPAATKHVAAHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P1N3</accession>
    <name>A0A2X0P1N3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C002g01379 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C002g01379</name>
        <name evidence="1" type="ORF">BQ5605_C002G01379</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY32553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P1N3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY32553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="124" mass="13969" checksum="D6F437EBD22D205D" modified="2018-09-12" version="1">MYKASLRSEGFAVIMNRDRRALFFGSDPSANTQSVLFPELRVPETGAFTEDELRYPRKRRIRLDDSEDTEFENTVNTRAMFMLNVTRIIGVPALLPPSSGGSCHPRACHRAPAARIEEQRGLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P3J1</accession>
    <name>A0A2X0P3J1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C003g02180 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C003g02180</name>
        <name evidence="3" type="ORF">BQ5605_C003G02180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P3J1"/>
    <dbReference type="STRING" id="796604.A0A2X0P3J1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="170"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY39235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="235" mass="26301" checksum="44FB5009666B0AC4" modified="2018-09-12" version="1">MYAVEPLQEYELADRALRPALIPEPGVPLLPALPQVSTSSFSTRTMVRSLLFLYQLAARWPKGLKTKEEPIDHRREEAVEAVNSYEDDDPAERDPPLPPDDGHEYRPYRVGRTPGLLENINEGNTLPLIALVSTSHPPLPKTFKDAMASPEAESWYAASVKELNSMGLHKVFKLSSPPTGARALGYRWVFTRKEDAEGNIINYKAQLVVQGFAPRVGIDYNKMLALVSNPERHEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P533</accession>
    <name>A0A2X0P533_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C004g03051 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C004g03051</name>
        <name evidence="5" type="ORF">BQ5605_C004G03051</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY69706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P533"/>
    <dbReference type="STRING" id="796604.A0A2X0P533"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041178">
        <property type="entry name" value="RPA43_OB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17875">
        <property type="entry name" value="RPA43_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RPA43 OB" evidence="4">
        <location>
            <begin position="186"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="108"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="248"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="372"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="134"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="257"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="391"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="409"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="430"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="448"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="469"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY69706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="478" mass="52763" checksum="3D3AD8C36CED280A" modified="2018-09-12" version="1">MPSHTPSSLHLKHHPTSPAKPEQQPNGTGTASSASTSSDEFIRFAATMRLPLAPVWSADGAAGGEMGSGGIEGVRQVLAGWVMRYLPPLQCVLLTFSPTPTFVHPTSTFPSHASPFPPVSSSTRSGLTLTSRENSNKENDPKPTKNPDEQDEQEEEDKVKFKVLPMISGTGFGLPIVHFTGVGWRPRVGQKIVGSPTLSTPSHVSLLLHNLFNATLPASHIPSDEWRFDPDYVVPAFIRERQKMAFPTTSATKTANEEAEEAERTEEGIEADAEGGEEKEEELAQEEEARLAMEEDEMYADRGWWVNVRTGEPMGGEKGSVEFTIVSLTIANSMITVTGSLLSSPFSSKVPPQNPIIATYRSGLSNAADVMRRHTTEEHNRKRKEMAKELGEDDDESQSESESESESESEAKDGRRGERAVSMSPVDQVPRVKEEGVVGRVQEERKEKTQKKDKKEKKKKKDKEEGSKKEKKKRKKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P6G1</accession>
    <name>A0A2X0P6G1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C001g00566 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C001g00566</name>
        <name evidence="4" type="ORF">BQ5605_C001G00566</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY47726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P6G1"/>
    <dbReference type="STRING" id="796604.A0A2X0P6G1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019007">
        <property type="entry name" value="Wbp11/ELF5/Saf1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12622">
        <property type="entry name" value="NpwBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09429">
        <property type="entry name" value="Wbp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Wbp11/ELF5/Saf1 N-terminal" evidence="3">
        <location>
            <begin position="4"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="391"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="335"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="407"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY47726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="481" mass="51802" checksum="463E53E20C1384FB" modified="2018-09-12" version="1">MAKNAVDAHRKALKKKEIKRNKDDRKKVREISTVKKDTRTLESDIKRLASKRDLTANDKEQLASLRSELERINKAKATYVEAHPEHRKFVYPERPEGANGPGGAGPSRDPPGLYTKDGKLKHPERSIYYDPVFNPFGAPPPGMPYRERPPTAEEMSAFMPAPMPAPPPAESEEDDDEDDSDEDDEDEDEDDDIVMPEGPPPGSDDSDEDSDDSLGDIPMPPGPPPPKAMTRPNGQQNITRPAIQRPSQGPRPPPYPQHRGSHPNFNPHQQYPPRPPPNFRPPPFHPNGPPRQPHHLPARPPPPSQLDPITGEMSTNYQAHQHARRNDAQANASSIPPPPTGDPPPPPPPPPSASVSSSATVTGLPTPFAAIGASAPAATISAAPQLRDLKKEATAFMPSHLRKKKATTASASTAASAGLGSIDAARGSGEGGNPIPERASLLGALKDAGISGQKSMGGAQTKAERAKEDYARFEAEMAEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P6W6</accession>
    <name>A0A2X0P6W6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00795 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00795</name>
        <name evidence="2" type="ORF">BQ5605_C001G00795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY49594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P6W6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY49594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="242" mass="26881" checksum="016C79508EE5D8F3" modified="2018-09-12" version="1">MSQVYEHIKARLPFVNITTRPQGRVDAPVPSGAPSASKHDLLVREKREASPSDRISGNLRPNTEPYSTDDKLVNSEDHANLPTYSEGRTTMTDLMLEAYPQEIVLDPWRPNGTWGDVLIVRMDPGSSGGLSHMWAFSASSSRTDSKGRWKGPRLDANVEYSKYSKKRCMGVFVCCDQSCPGKRRPHTSLLTASRSKLFQEETPQLVTGRPKKAATRKHLAPNVEAYHLDNTCGVPSSLRVVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P6X2</accession>
    <name>A0A2X0P6X2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C005g03593 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C005g03593</name>
        <name evidence="8" type="ORF">BQ5605_C005G03593</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0P6X2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053238">
        <property type="entry name" value="RING-H2_zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14155:SF627">
        <property type="entry name" value="OS06G0192800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14155">
        <property type="entry name" value="RING FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="1509"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="169"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="317"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="458"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="581"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="741"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="886"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="946"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1030"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1104"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1221"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1309"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1263"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="106"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="389"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="581"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="776"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="976"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1104"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1125"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1310"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1322"/>
            <end position="1347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY77274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1547" mass="164723" checksum="85B1A45C1993E7C1" modified="2018-09-12" version="1">MNRSAGSVALPRLDPPHPAASSPSAVAVASHPIAIDLVGSQRAKPSHSSHTGLPTPSSLPAQPVRSHRCVVQPPQLPSYRPSDSGGSLQVISVDGRSRSRSRSRPRASVTAAVTAAATTTTADDNGAAARPAAPTTPPSSSDESTLDDDLASLPGALFVMEDLDLELASTSSSSSSSMPHPFDRAQPPPAAPPSSGSPGARAASVTVAPRTFGRAPDGPAATYERLTGPDRSSGSTTRVSADATSPSATSSSTLSSSYPYPSPRSAPTPSAFSSNIVIRRTHRARYSPHVEPAPASMQVQVTPSRGRHPAAIPLATSDVASRPATPSISVKRAYDEVSPTTGSTPPAMPVDAEMHDANDESAAPGRSPSPCSGLDDSANMAPPPAWHTFESQRASVSGRSSTFSLDSSQTGRNSPATLRRRTPISTSISPVRPAPTVTSGHAYLDLYDEVGLDRLGISRDRSKRRRSATIPHSEGSERSTPSTSTAPATSGTAGTTFAPALGRYVPRPIPIDPVLVAEPWPVPPSVTVRGAAAASPASSTLATSSSQTMSFREELESQFSNLRPSVTLSMPSSTIPTIAARTTATDASSSEPSPRRSVGGFTRFWQAGNPTGPTPISSNASTMATSSAVTIPVTAGARDWSTTPPTLSLRTRAARSSTFPQTLPSSTAPSQVMDYRWMVDDLSSTRAHAADLPDSTTTYAREVLQRATERLERAEATMSRVFGATTPSTLEERILARRQSRLNFHLSPPAGTESSGEDTEMNLDRTTRAASEGIWASSPSVGEGSSSGGSSATAPASANSPTTTTSRTRYFLTNLRARRPRLARNSTGVPSPEVMSSERERDGWLDDLRDEGAVSTSEVSVVAPALWGEEQSQSPQHLDVAHAGAIDSAPSSMAPRRMRGPTERANERWRLGQAPVTAQTTTTNVTASASGLNTPSLVRESYRVDPRSSTTHTLGQRAAVATEGPTRTLPWRSMDFRSTITAPRTTENGTSGGDLASEIRRRYNTLREAESTIPTPVRPVDPEVTPWEDARLSDLSEDSTVSGGSTLPRPERVAPFALTPRFAPPRHRPARGLDLSLMTPSLDSGNDSREVEALEARAAAALRPSALPPMLSSGSMGRRPTHGSNETRPDDLPRFDPFGLDAVDTATGSRSNRPALLAAMRASSQLAQGTTAHRSRTSLADALTRYDAARLADEREQDDLRQRRAEEGAIDDNARRYVIEETEWEREDDDDDDPGSDVDMELWRPDVRRTFSEEVAADRSRWVRAEMEASAESEQRARQAQERLRARSEALAALRRDRGQMRHLMGNLTAPLTSGLSGPSITRTTTTTTTTSASPPTSTTTVNTASVGAARDAGDQATSRSPGTRRRGLSDFFRGVGATAHFGTSLFDDDSLLAFFGRDSVALDPRNYLADDLFDSSYDALLRLSEQLGDVVKPKGVPEDKLAALRTFKYKAWPMPERREASRSPSMTTTISTVPVASTSTSRPFGSTMVDPVLVPALARKGVEKEERCSVCLMDYDDDDECMLGMCAHGFHRECLLAWLKEHGTCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P8J9</accession>
    <name>A0A2X0P8J9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g04182 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g04182</name>
        <name evidence="2" type="ORF">BQ5605_C006G04182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY56858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P8J9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY56858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="326" mass="36706" checksum="685DAEFE006064E8" modified="2018-09-12" version="1">MELTSYNGGPIDQQEARDELRALVRQYQLFKIQPDHRSDFRFILSRMHCGAGFQEVVPFELRQDPKYLENYESELVSMAKTYVSTNLKDVRKLAATRAKMFLESDYGNPYLEQHRARAAGNDDAPQPASRLPNLETLFTLYGNDDTVENILRPLLLGGTKASTHRKVDLPYRRRWITTVVALIGWEVACWVTQYEGRKLKRANPDTNNKQANAQYTHSSVDTSYLVHTVNRYMAHPLPGGTASGPDDPEGSDGLVWCWDMTNGTAFEKVKAKPDLPPAPDPVERRAAGTGCSEQDFEQETTALASAVRAFFDGDRPETQERAADSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P904</accession>
    <name>A0A2X0P904_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g04342 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g04342</name>
        <name evidence="1" type="ORF">BQ5605_C006G04342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY58121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P904"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY58121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="49" mass="5609" checksum="D71ECF6094EB01F7" modified="2018-09-12" version="1">MRFSNFGVRFYNLGDQGSDCARFASFTKGGRPIEKVCTPETSLMRWTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P972</accession>
    <name>A0A2X0P972_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C009g05655</name>
        <name evidence="10" type="ORF">BQ5605_C009G05655</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY83787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P972"/>
    <dbReference type="STRING" id="796604.A0A2X0P972"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071021">
        <property type="term" value="C:U2-type post-spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004098">
        <property type="entry name" value="Prp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039979">
        <property type="entry name" value="PRPF18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007:SF19">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02840">
        <property type="entry name" value="Prp18"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00500">
        <property type="entry name" value="SFM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47938">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="9">
        <location>
            <begin position="125"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="14"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="87"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY83787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="450" mass="50557" checksum="189F2652AB17539B" modified="2018-09-12" version="1">MNFLKAEIANKKRALELAHSQPTTTDSTSTTTTDPPTASTSASTTHATKYIRRGDLERIRVEQQQRQDLLHAALKVAQLEVDSNQTLAVASSSSSSTTTTTTTATTEHLSPLTHVTDSRPEAFNISNEEAIKRLRYKAQPIRLFGESDKERRLRLRALELIEERSEGQRNEFMNVMHNVDKDMNLQQVADKIISSTPKIDNKKSTMTTVRDEDGPLLPEGENRTDNLLHPKDQDIIVDVSLVKSNPHKVYPQIYHALKVGTPFLLTSATLLRAHESAPCLQRVLKEWEQSLADRPEAVRRSTQGRMAAATQQTSAEYLKPLFKSLRKRVSRSNKPKPTHDQVTHSVSSPSQDLAPDVLQAIAEITYNMQIREYLRANDAYLRLSIGNAPWPIGVTMVGIHERSGREKIFSNNVAHVLNDETSRKYIQSLKRLLTFAQTVRPPSDLSQIMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PAE6</accession>
    <name>A0A2X0PAE6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C004g02616</name>
        <name evidence="7" type="ORF">BQ5605_C004G02616</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY66047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PAE6"/>
    <dbReference type="STRING" id="796604.A0A2X0PAE6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="6">
        <location>
            <begin position="111"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY66047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="331" mass="37312" checksum="7633A930D07D92E3" modified="2018-09-12" version="1">MSGTSSLDRQIQQLKECQPISEQQVKDLCLKAREILVEEANVQWIDSPVTICGDIHGQFWDLLELFNVGGSCPDTNYLFLGDYVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYDECLKKFGSASVWRYCCEVFDYLSLGAVVDGRVFCVHGGLSPNVQSLDQIRLIDRKQEVPHDGAMCDLLWSDPDDIEGWGLSPRGAGYLFGADVVRHFVHNNDLDLIARAHQLVRLLALSGAAILDDGTDRRSVIHQVMEGHKLMFENLIVTVWSAPNYCYRCGNVASILTLDENLQSTYKSFDAAQQDSRGIPAKSTALQYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PB13</accession>
    <name>A0A2X0PB13_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">vesicle-fusing ATPase</fullName>
            <ecNumber evidence="3">3.6.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BQ5605_C004g02846</name>
        <name evidence="16" type="ORF">BQ5605_C004G02846</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="3"/>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY68082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PB13"/>
    <dbReference type="STRING" id="796604.A0A2X0PB13"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19521">
        <property type="entry name" value="RecA-like_VPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.80:FF:000004">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000043">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000015">
        <property type="entry name" value="vacuolar protein sorting-associated protein 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF83">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MIT" evidence="15">
        <location>
            <begin position="15"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="179"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="85"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="376"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SGY68082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="451" mass="49880" checksum="FE7E3AF8B0D9BD38" modified="2018-09-12" version="1">MTATTTIDHNDDTVHGPPAQKACELVKQAIDADVKQEWAEAFKLYKNSLDYFNMAYKYEKNSKLRDLIRSKVEEYLDRAEKLKDHIQSTEDKRQKTAVGNNGKAQTSSGGGAQKKGGGGDDDDADTKKLREGLSSAILSETPNVRWEDVAGLDAAKESLKEAVILPIKFPHLFTGKRTPWRGILLYGPPGTGKSYLAKAVATEAKSTFFSVSSSDLVSKWMGESERYLFQMARENKPAIIFVDEIDSLCGTRGEGESEASRRIKTEFLVQMNGVGNEMQGVLVLGATNIPWALDIAIKRRFEKRIYIPLPEPDARKRMFELNVGTTPCTLSQQEYRTLASKTEGYSGSDLAVVVRDALMQPVRKVLSATHFKEVEVPDPEDSSRTIKKMTPCSPGDAGAAEKTWSDVSSDELLEPPLGYNDFIRAVQSARPTVTKDDIVRHLEFANDAGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PB90</accession>
    <name>A0A2X0PB90_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C004g02926 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C004g02926</name>
        <name evidence="8" type="ORF">BQ5605_C004G02926</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY68874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0PB90"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF26">
        <property type="entry name" value="FAMILY HELICASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="1267"/>
            <end position="1641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="114"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2197"/>
            <end position="2263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2289"/>
            <end position="2343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2380"/>
            <end position="2465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2514"/>
            <end position="2536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="60"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="2303"/>
            <end position="2319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="2322"/>
            <end position="2335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2429"/>
            <end position="2438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2446"/>
            <end position="2456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="2523"/>
            <end position="2536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY68874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2571" mass="285429" checksum="1850B1265DCAF879" modified="2018-09-12" version="1">MVLRRSRSSSSNVRYVDSDDDDDEDDFAPSSATKAPRKGGNAKALSTGAKGKVKSRRAMDDDDSDFVIEGVEAEEQDDDDFMMDEDLQDEEEGEGASSVEEDFQEDDLIVVEKGARGSKAAGGRKGASGKTSQNVYSRGKSALKGEDGTKGASLDESLPPMSDLSEIFSDLVGKVKDELGQVCDQLGNRKLRVGTMCSGTESPLLALGLISESLEELTGRKLQVEHIFSCEIEPFKQAYIERNFSPPLLFRDVTELGGEQAKTAYGSIADIPGHIDMLVAGTSCVDYSPLNTKQKTIDDQGESGRTFFGMLDYVEKHQPPIVILENVSNAPWDEVVKKFHSIKYHAVYVRLDTKHYYIPHTRSRAYLIAVPRSSGVEVVEKWATMMKKFVRPCSSPLEAFLLPTDDPRIHRARQDLSKIAMTKDGVKRAPTDWIRCEGRHAQAREQEFLGLQRPLTAWKDNGGAPTMPDGAWNDWASAQTERVWDLMDISYMRLALENTDVSYKSALWNLSQNVDRQTSNPILGISSCLTPNMIAYLASRGGPIIGLEALALQGLPINKLLLTRENTDQLADLAGNAMSSTVVGSAILAALLVARKTLGSNHPETNEDAPAGEETERIGSVDIEGRIRGEERLLPHPVDLAAFNPLTDGFLERAAQTARKCLCEGRTSNTPDDVAIMVCDACGHSTCAKHVARPDHRYRVETGKRASPDSFIAELKGLLPMRFTLAGFDLKSLQDRVADLLAGGVPLEESQSAYYERIAAAVDGVEFHFSEFVRRREWIVTFAAEDATLELHISAHGCEWLLRVACERSLPVNDPLRKLLEVPIARNQLSPTAQNLLDGQWELAAVIDGAGKGKQAFSIDIEVVGDMVPSWRARMGLVDFLGEKNHDGVEIAPSEKRPYRMRVKMSDTITPLVDRSLDGLYELEAECGTACQSLYRRIEPVESKPLYFFFDPTRFGTADIDSFVFSDDCERLEYGEHRNKLATLAPSWRLPGTFPTVSPQSQIRVAKAEALASSGTIAVSLPTMWTPLPGSHIVHEKMDRVDATFSTLSTTFELTADAVACSFADNLLVARVEQAPPARKLKWATEEWHEVDLHHEGPEVFSKISWMLTKIPAWDALREWQHITGELEMDCQACCPPPPMIHWVKRSEQKAKLLQVSIVAVEDGQQAARFERALKARPSPLLVHTRQTATHFEFRIGLNAATLAHRALGTLPVNRLHTYEMSEPTVIWRLKSSNGVELGYGKDGEPTEFSIPSNDADVMAGQPPHFKVFQLRNEQRRSLQWMIEQEANPRPWVEEEVAEAILPQLGWQAEAKASREVTVRGGVLADAVGYGKTAITIALISARLGQTELPIETDRIAVKATLIVVPAHLTSQWPSEIEKFTQGANQNFELLTVKDLNDLRRKTIEDFRKADIILVAETVFNSPLYWPQLGDWSASERGVKYDKNAGRYFRTCVNQTVAALPAQVEKLLNNDAKGVFDSIKAARKARDQIKDLVDEPSKRLKGQAAVFAKEAAEFLEKRDGKKPQAKQELKVKKDLEKKVEADPWNLGSKDTQNNWEQMTSPPLSIFSYERIVIDEFTYTDGPQLAAVHAIRARSRWILSGTPPLETFAQVKTIANLLHVHLGVDDESEFQGGSNGARYKEKTAAEQFHSFRDVHTVGWHKNRDQIAQKFLDQFARQNWADTTTISYSDSIKMIDLPAAEMAIYRELEHHLLALSNDLGKIQRIKKEKRGDREVRLSEALGNSKSPEEALLKRCSHFSMDIEEYDDAVKHIGALHVCERILAKRVAQLTSCEEQFLQLVNTCAAQQRWLDKHGYYKGSFGTKGSEPQHFKMFLQTVFGKSQDEEGSEAIMTFCKMVGCSESGEISKIAPEGAPEPTDMGAFLTKNGQTWDDEKHRAIVGKKIPEEDYRKSKTWILRQNVSAVERLRKEVIGRYRSRRYFQCVRNVQRSKDNSYEGITLLSCCGHSGPSDEIERLVINQAQPQCIEPKCDARVSRNNFVRAETLGVDRSSGTFGVKLETLVRLILEKVPKDDRVLVFVQFEDLFAKTREALEAYGIKTAVVEGTAKQKGTALHNFQDPDNRSHRVLLLQVTDKSASGANLTVANWAFFVSPLHTDTTQEYKAFETQAIGRIRRLALLPLHSYGQTKAVSIFRLLTRSTIDVETFEQRSGKIVDKLVAEQEPLELSDVAHPKTQEFEEMVAERSRGGGNRAIAPLVTKQVKKARPVAAPKKSRSSTNSKGTGKGKARRNSFSEDDPSDPSDLSDLSDLPAIVLSDDDVPDADSEADQADLESLLVGTSRPSSLNKRTTASSVTRRRSTVAWSDQVVDDEDDEDNDEEPVSLSSSVRSNLLQSRPFPVLIRSLDTVPQRRSSARLRRPNIQNRASITLLDGKNDTMDEDEPEARPAVVESPITANVPVFKTQVPAKRPRRSDAASSNSSPATVASAPRATRSSLDKTTPSRPMKRRQTFELVVPFRRLPSSPVKSQDAARLTSSPLKSCSALAQALNVDLLQAPAMLKKPSTSGTPETATSVASAPESPAEMAEAEALDKIVAERQGLITDASMTEGDAELWKDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PBF3</accession>
    <name>A0A2X0PBF3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C004g02996 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C004g02996</name>
        <name evidence="2" type="ORF">BQ5605_C004G02996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY69321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PBF3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY69321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="363" mass="38981" checksum="299144EA11ECD8B6" modified="2018-09-12" version="1">MTIANAHKLLDQELLTVPEALLGQHQDVRQALVSLVGTVDVVILDGSTLFSEWFSAARSGTSPRKQAQRFVGSVRAEADHIVAATAGRIHLVIVFDHASARPALKARPTHTSRDNGNGVRRSPQVSPDNFQRRSSGRHTDPMTEWLTNFGGQAEPTLAGHVFDMSSEVTVIISAHEADPLIAASTRVGVIGSHRVVRVIDLKILEGQGKFPGAEGRFVAGLMMGCDYLPIGLQGYGPAKLEKLDPSVFQLATWSQGYEHATAVLYRVGTKLDAVFSPSAMQLLPSATCTTSSGATWSQSHRAPREPSNTPPGSSSPTLRSMGVRTNTCVASPRPRCGRSVQPRTFDGPRAQRLASEQPPESVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PBV4</accession>
    <name>A0A2X0PBV4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C031g10896 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C031g10896</name>
        <name evidence="1" type="ORF">BQ5605_C031G10896</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000068">
        <property type="protein sequence ID" value="SGZ05863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PBV4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ05863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="66" mass="7596" checksum="813BDED55B592DA6" modified="2018-09-12" version="1">MVRSFALVKIYGMAREGRSLVSGQYPRVKARLVSLYWIAFRSAPTAQQPALEIQPREDIRRCRGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PC40</accession>
    <name>A0A2X0PC40_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM7</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">BQ5605_C005g03268</name>
        <name evidence="12" type="synonym">MCM7</name>
        <name evidence="15" type="ORF">BQ5605_C005G03268</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY73157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PC40"/>
    <dbReference type="STRING" id="796604.A0A2X0PC40"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17758">
        <property type="entry name" value="MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000004">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000288">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008050">
        <property type="entry name" value="MCM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF26">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24901">
        <property type="entry name" value="WHD_MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01663">
        <property type="entry name" value="MCMPROTEIN7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="14">
        <location>
            <begin position="362"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="713"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SGY73157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="795" mass="89099" checksum="11DB92438DD9D6BB" modified="2018-09-12" version="1">MATALPVVDLGLDYDEDLERIRTFLTKFKVTRPARQTERDEDDETEMEDEDDEITPDDVPGVLKYRQQLQRVANREQERLVIDLEDLNQDLTNGQPLVDLIKGNTQRYVKLFSQAVDEELPAPTEDIRDKADILDVIQFQRMSKNDENEQDGVNIFPANLLRRYNLYFRPLASDVPLAVREVRGSHLGKLITVRGIVTRVSEVKPLLQVNAYTCDSCGAEIFQDIDKRKITPLTECISEICKLNNAKGQLHMQTRACKFTPFQECKIQEMTDQVPVGHIPRSMTIHLYGNQTRLVSPGDVVHIGGVFLPIPYEGFKALKLGLLTDSYLEAHHIHQLKKQYESMKLTPKIYDEIAELKRDPALYSKLASSIAPEIFGHEDVKKALLLLLVGGVTKSMGDGMRIRGDLNVCLMGDPGVAKSQLLKYISKVAPRGVYTTGRGSSGVGLTAAVMRDPVTDEFVLEGGALVLADNGIACIDEFDKMDESDRTAIHEVMEQQTISISKAGITTTLNARTSILAAANPLYGRYNPKISPVDNINLPAALLSRFDLLFLILDTPSRDDDQRLAEHVTYVHMHSEHPPLQHTPISPVLMRHYIALVRQKRPTVPRDVSNYVVQAYVSLRKETKAAEDRNQFFTYTSARTLLGVLRLSQALARLRFADAVETADVDEALRLMECSKASLHDHENRDRDVDQTTTSKIFTLIKTMAAAGQARVRGAGRSGRLGRGPPRMEVDGDDEQGVEADGFNPELNMREVRERVIAKGFTEDQFKDCLDTYAEVGVWQLEANETILKFLGGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PCB9</accession>
    <name>A0A2X0PCB9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C005g03358 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C005g03358</name>
        <name evidence="4" type="ORF">BQ5605_C005G03358</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY74364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PCB9"/>
    <dbReference type="STRING" id="796604.A0A2X0PCB9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021278">
        <property type="entry name" value="ATP19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28074">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT K, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28074:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT K, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11022">
        <property type="entry name" value="ATP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY74364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="129" mass="13952" checksum="D97D68A0FD1980C7" modified="2018-09-12" version="1">MSSLATKGARSYALSITHSIWTSTAAHCSLPQRPLIPTSPTRKQQLTFQPLFHCSTIAGKKILNEYIALGVFGMTGFGAWAATRGGDAKATKIAESTSAKLNSSSEEEAAFIQNFINDLEHQDKAQNKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PE03</accession>
    <name>A0A2X0PE03_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C008g04988 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C008g04988</name>
        <name evidence="2" type="ORF">BQ5605_C008G04988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY78914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PE03"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY78914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="101" mass="11376" checksum="1EAA4A4F40CBFBC9" modified="2018-09-12" version="1">MPSKGLPPFGACPACEMPPAEPLQVAQMPPRKQGAQLQQKGSLTTKQRASQQSKEGLFEAWSHAQHQPKRRAPQATFDRPRRRPHTLGTRFRGLLSDFWSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PFV7</accession>
    <name>A0A2X0PFV7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C009g05689 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C009g05689</name>
        <name evidence="2" type="ORF">BQ5605_C009G05689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY84321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PFV7"/>
    <dbReference type="STRING" id="796604.A0A2X0PFV7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY84321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="614" mass="67385" checksum="885DDB57D33BF985" modified="2018-09-12" version="1">MTIPAPTPFGPLPTELEHLHSTFGYKFDPHLYLHLRLALASGASHLLVRLSSTTLDQHERAEAVAALVAQVDWICRTLYGLETNAVQCPRHPTSANAFLRSWLVPDPNHTAFVPDSASTRFIPRLATVPSTSRAVSPSTNPNPALANPSRSMSQPRSPLVGLDIDIERNASSSLLHGLAESGKPSILTGATSRSTSHELRPDPQTQTSLDLTPRPTHSQTPDHSGLATPMTTSAVQWGPTSPTISSPTFVQRSKLDLLHLNSPTLTRQRRSTITVRSSSSLPLSSRRLPQVVILERMDRTSPRTQQGILKTLRERRITLDRPVNTSSGLGLGRDPNSTGTPTSTTTTTTTTAMGSGSGAGTLNGFLRSRRASEEVQSGEDRKEDVDWVLPEGFLCIAIVLEEGNRGDWGGLDRYLVSLKRKRGEGLVARDTVSLKLMQRTSLRKLDQFALSLTIHPDTYDFRHPPTHLSHPLSNPPISSLPFPSTILPSTFSDALINYQNDLISTLRHHPQLDGRFLTARASKDLTTILKTSIVLRQGHSVTPNQNEERSPPNPIVLPNDVIHVLLPVLGHRLRIRNAKDEKSVFWGSEIGALERRRAREGGVESVIRKVTEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PG08</accession>
    <name>A0A2X0PG08_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C009g05749 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C009g05749</name>
        <name evidence="2" type="ORF">BQ5605_C009G05749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY85279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PG08"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY85279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="295" mass="31244" checksum="0A043BDD827AD358" modified="2018-09-12" version="1">MAGGYFHYESDSSVPSSSDRSQACSPTTSLMNHPIGHAGAGAGTTGTRGASLDLSPSSTRSSGTGMMRDPFVDPRLSLDSWSRQSSIESSNGNAYEATHSRGTKGESYYYDDSSDQSGSERPGMRPFMGRSNSDVQRELQDALQDGLPTPRKEEKLTSGSGLASRIMARGESRKSSTTSSTSSSTGSTYSGSTSGGGGLLSQFRTGSGWFAPVVPPEPKLTRAEREQLEKERIEELRNSGANASRNRPSFMKRMSSGVEMMGSFGKDSSGISTSPAKQGRARSGTATTITETYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PG56</accession>
    <name>A0A2X0PG56_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C026g10138 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C026g10138</name>
        <name evidence="6" type="ORF">BQ5605_C026G10138</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ27603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PG56"/>
    <dbReference type="STRING" id="796604.A0A2X0PG56"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040240">
        <property type="entry name" value="TAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022591">
        <property type="entry name" value="TAF1_HAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12157">
        <property type="entry name" value="DUF3591"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 1 histone acetyltransferase" evidence="5">
        <location>
            <begin position="500"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="44"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="985"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1158"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1081"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1172"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1208"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1230"/>
            <end position="1250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGZ27603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1260" mass="140076" checksum="CEBFDA52D26F48B4" modified="2018-09-12" version="1">MENDDPSSVLSQLGSFALTEVFNDLGLDLERDSLSSVQSQLGLGATHHSGSATGGDGLSKDLVYDGKFVDEEEEEEEEEEEEEESEDDLERQVDQEMYDESHTTTSLPLSTPALTGRKPTSLVRGEEDDFDEDDQQDPQQTPTVTDKDVEMAHSNSHSEEEHLLQSVKAEPIDHEHTTSSIPHEPLATIAEVEPTPLLDRLRLGPTPTPVPVPVPVPVPVPAPVPAPAPAPAIFPSTTNDHPTPSISTAAPSATSFAFMLDPLPVSMMPIVPPMPQYSVKELFPSFEYSQTLDFTDLFAVRPRKRAKKLVSIPQFTLPPEQEIKTSKSTRDTLLEPMKPLPPTSHLKQLLSESQYKETEEWEEEGNSEDELYKAIERSNRMTTSKWQIPDSIHGFDNAELDDWEDKIIWGPDTTAPRTLIHDPLAPRNIDFERGDWTKSIIWDASKPYKDFTRLNLNLNDRQMILEVQAPTLNSTTASDKPTEVTPIGLVIEKEPGLDPFNISNDREYVVTKDAKQKIRQTFGSLEVQHAHPAAKLQLPFYKTRMTKNDMRSFHRPTLQFPQNVPLSFDKSRSSKKKKDALGKKVKGNELRHMIDITLKDTSPFVLWEYSEETPPIISNVGMGSIIVNYYRKRDPTDNFVPNLDLGEPLILEGTDESPFKAFGYVHPGQTVPALYNNLIRAPLFRHRPPTTDFLICRVTIEGETKYYIREIKNMFVLGQTYPLNEVPGPHSRKVTTLVKNRLQNITFKLIEKNPHHRIKVHRLTRYFPDQNDLQMRQRLKEFMEFNRKGPNQGFWMIKKTVVVPDDTEMMKLATPEMVCLAESMQVGLRHLQDAGYGAAAEEGGAGDDDSKLDIEQQLAPWITTKNFINATANKAMLKLHGEGDPTGRGEAFSFLRTSMKDIFLRAGELMQERLAQMESRPKSAHRYNVQEQQDVYKEEIARIWKAQWDSLRNPIEPDLTAEDEERARGAAVTAAANEKMVKIRQRQERHGTNSLIDHGTPVPGTPGPGGGSRASSPAESVGSGAGVEKQAKTLRIKRLIEGKWETEIVRDPTIISAYVRQRKTIEEEKTEADDLLPSDDEGKNERARKRLKEQLEKLKRNQERRLARKSAKLGVPISQVNVGGKGYVKTETTRICGNCGQRGHMKTSKKLCPRWHEFNAPKGPEPSSTLGSGFGGGLALPSLGGGGGPSGPNKAGGKAGSPPPIQVGTPSVSTPTASGSAKATLKFKLSTNNSGSASSPPAAAPATPSGDTAMGEVEHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PHC7</accession>
    <name>A0A2X0PHC7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C033g11213 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C033g11213</name>
        <name evidence="1" type="ORF">BQ5605_C033G11213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000066">
        <property type="protein sequence ID" value="SGZ02514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PHC7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ02514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="49" mass="5768" checksum="BEF595210B11E97E" modified="2018-09-12" version="1">MNMIRSATESELLHYHFYAAKLSELYALQKKVHRCPHDDERGHVDVEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PHK2</accession>
    <name>A0A2X0PHK2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C032g11058 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C032g11058</name>
        <name evidence="2" type="ORF">BQ5605_C032G11058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000067">
        <property type="protein sequence ID" value="SGZ04366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PHK2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ04366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="248" mass="26656" checksum="F44468E682DABE01" modified="2018-09-12" version="1">MGKLESHSPFCDMDNKPNLANFEHEAPAGLSAFSSLLQRFLHPTAAGSRDRRDWMSKVPPASALPPRPRSLAMREPAAASPVASTSSSNIIVPIKASVTPARSQSRRPRRSSRSSTSRSQPAITSPSTRPSTTTSLRPGPRASLLSSPHFESSPSDPSSESSLSDVDGENDICYGSTDDDNFALSSRTSSRLVNKHKKRKRSASSKPALPPSCGLEGRLWWMYQHSVVSAAPACGVGVPIRSHVQALW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PJ34</accession>
    <name>A0A2X0PJ34_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C029g10619 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C029g10619</name>
        <name evidence="2" type="ORF">BQ5605_C029G10619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ14803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PJ34"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ14803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="485" mass="54744" checksum="E60458D5012D79FA" modified="2018-09-12" version="1">MCCLSCLLPATRQRLPLPPAGEVGTAVWYVLQRRQILVKELHESRPTAFGLIGGVFAGRAKQVLRRSRGSPRHFGRRLSTLNNTQIQSLVTESSRRSSGPSAVDVHHTTIDLDAFRRELGLTPDPAAEHAERDRDDVLNIPGTRHMVTYTARQIQQRTFDEHARGEASSPSPRPPMAPPIQADFDEAANPSGMFWDDERHSEYGGGHERDFSPAPYFSDRTSLESFEPATRGQSKKETYKQFVFNDARLRSLERPALLRQYIAATVLKEYRTRIQDFDDILARIFTVPVDIAAEYEESRLFREILSPLYQECQRPLPEDEIRTDEDQEGSDRLFKMDPEGVPPFSRETCPGRVLGSVRKRTSHLASSAQTICNDGACQDLVLLLVHVPEPPKPPTDADQEPERKKIWDSWIVECAHRWLALLSKQRETYRWMRKREEDAISEHSSATGQHSDHGSAAGSEAKSNHSALSELTSLSKLERGLDTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PKB5</accession>
    <name>A0A2X0PKB5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C020g09074 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C020g09074</name>
        <name evidence="4" type="ORF">BQ5605_C020G09074</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPC synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000082">
        <property type="protein sequence ID" value="SGZ16865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PKB5"/>
    <dbReference type="STRING" id="796604.A0A2X0PKB5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12290">
        <property type="entry name" value="CORNICHON-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/pantothenate metabolism flavoprotein C-terminal" evidence="3">
        <location>
            <begin position="283"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="188"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ16865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="426" mass="47707" checksum="B69AD6EDE7C8715A" modified="2018-09-12" version="1">MASADRPQFSAEQFFAEQPPPARLQEHLNAVQAFVERNASAGRRVVLVTVSNTFIQKPKTTYLTIDTWHAPAARSLVWLNLTEPLDIQSGGTTVPLEHNVVRFLDNFSAGTRGSASAEHFLRTGDYAVIFLYRQHSLKPFSRHYSHSTNPFLDLLTIVNDHEHAFRVPSKDDNDGFLFPPVPAVGTVSAPLSRRPSALDGSDYKTRPKSPVTSDGSPQIQIPPPHLEPMLSLLRSYKLVQKMKILYSIPYTTIDEYLWYLRGVSRVMGTAKDSQGQALGRRGMYYLAAAVSDFFIPFQRMSTHKIQSGKGSLVIEMDQVPKVLKAMVDEWSNDGFIVSFKLETDPAILIPKARAALERYGHQLVIGNTLTNRKHEVIFVHPSGKEDWLRIELPTALGEGKAVREIEEDIIARLVGLHERWIDGKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PKZ4</accession>
    <name>A0A2X0PKZ4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sm protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C023g09729</name>
        <name evidence="12" type="ORF">BQ5605_C023G09729</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the snRNP SmB/SmN family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ24521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PKZ4"/>
    <dbReference type="STRING" id="796604.A0A2X0PKZ4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070990">
        <property type="term" value="F:snRNP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01717">
        <property type="entry name" value="Sm_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="19"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGZ24521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="172" mass="18267" checksum="5C4673955C7A703D" modified="2018-09-12" version="1">MASQHKAHFFHSGVVNSSKKGGKLASIINYRVKVTLNDTRTLIGQLLAFDKYMNLVLAECEEFRRVKSSASKAAAVPGVTIEDEDDGEDEMKRTLGLVILRGETIVTLTVQGPPPVQEEQRAGAHPHIGMGPGVGAPAGRGMGLAPPTMRQAPQTFAPPPGMPGLMCAPRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PMR7</accession>
    <name>A0A2X0PMR7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C026g10112 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C026g10112</name>
        <name evidence="3" type="ORF">BQ5605_C026G10112</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ27521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0PMR7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1268"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="650"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="712"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1779"/>
            <end position="1830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="713"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1819"/>
            <end position="1830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ27521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1988" mass="219320" checksum="A27F5C68C683B2C2" modified="2018-09-12" version="1">MQTGDPGSAPGARAPPPPASAPTSLPIAGTKETQATQVAGRTATYAAATNSSVVSNETPAQQQDRLARLQALPGILAAIQAVPGNRADRFVQAIFATPDFPSTVATALKFSALNATRNIINPFANALEVSLSHKSTGRASATDKGELVACVRTLLSPNTPICFDTGVPLSGDLEAFMPRITGLQHSSTFRTGVLHHRITVGFVSAEARDAALASAPMLVWNSANARFAKAHPFHRNMLEMRINVGVVRPPSKEQIVAAFQSIVQQLSTKGHSCQLVQVLRVIHVDTAKAYAHTVGDFSAFIHFDDASLFQHPTTTLKEILPSRMDLPTRGLDVTAVRHDYEKEAPCARCHFAGHVERCPLMQAANRKEAEDLARHAVMRGAGMVGGGEQTGVGRAATTTTNNIRPTANNNNTSEVVAPSRALGTDQLESRNRFAGLEVEGGQEDDIEEEVAGKEGEEKEQVKEGDEDTGAKADDEDSDSDGNAGAGIDKAGGDGKDDDKDDDEDDDKDEQDDSSEGSERRGDDVMKDGAEEEDEGMETEVEEEVEQEQGVQDDSIMIIDDGQTTITTVSRESTPRSPSWPPLSPETLAKSLREGAEWDRANAEAAARVQAENEAIINAQLDAQEPLVRHQFAEWGQEDGQLRFINIRGTGSRSNKKMKRSQTVADLSDPSDDPVDVKRVLNRVKGRAGKEVAGQGKRVTRSMSAAAAMQVEGAKAKAEKGKGVEEEKRWSDHEPEDDILPEFPLFEDNITAKSTWNVRRCMGIPEKRRDIYTYLSTFKASAILLQEHFIKPELWQCIKDEYEGKAFISKHCLTLIPADSPLIDAEILRTHSALDGRILVTSFRLRGDIRILEINNLYAPVDTKQRLTFFDKLHFHRTQSTHLRLLGGDLNDCPLPAIDRRNQGRHGHHWPILIGKLDSPYTDCIRFKHPLTPSFTRPNIVRKRPKSFSRLDYFLLQRTHQKRLVQASTIYDHPKDLSDHRPVSIVLVLSDERGDAAQPNNSLPTTSNQLHRINAATFKTAAFQGMLEGWLEGASGEEPVGELEVVLGNCEKEGRELARREHRERVERMAVLVGRVQDLEALPVMGDEETAEWTRTTEELRRAVNERARQLRIRAHVPEIATEERLSRPVHAKLAARSSDSKITALRLPNGELTHDIDVALDHTQAHFQRLYNLEPRDRDHVERLRDDFLAPIRAARTCDDPSSDPLFLRRLSEAHIELLQQPITEDEVVAAIATTHPGRSPGPSGVPYELYHTAPRAWAKALSRAFNAMTERGSLSPKQGQGLVRLLFKHHKIGADRAELSSYRPITLRECDYKLFTKVYVARLNHVLPDLLPPQQHGFVKGRRSADASFHLRLLIEELGARGTEFPDAALLSLDQSSAYDLVEHEWIFAIFDALGAPATFQRVLRMLYSGDSTTARYIINGFLTPPVRLTCGLGQGDPASSSVWDVVFQPFLDALHRRGIALNLSLPTIHPYPQSRAITSLAFADDVVVAVAGSESLTLLDDLALDWRLATNGRLNTDKTVVLPIGAEGESLEWIGLSFDPTGNTELANILHILSADIPPLEVVKELDRILVDFVRGGKRRSCYGKDVVFTPRFKGGLGVMRMQDVVDSVAARVWDVLLGGSDAIWQGLARAAIVRAHPAPDFDLATDAWPCDYTPIRTDLHPRWQAVLKVPSTHNAQVKPRTLTLANLLALPIKLHTLHYLPGAPAVSRSPYDADYAAFANYAKVADLFRRELYPGGGFHLWTPPTDVVVSNSELRSTEPPTTRAHCGMVPTCDQSIKVHTNSSTGGGSTNQTGPPRVRPRSEVRPTTPLESILPHPIDPPQRLPRPALPDQSTQYNLLSMDRPYTIRRVRRVLNAKAFTDTIGFRDSLQPDDLKGFWKGVNSKALTARGNASLQFHQKHDDSPACLVCGAPKDDREHYFLDCVDSGNVWIAARSVLCDALGLDTIDNTHYTAVNACSDFRSSRPVCAIKKERGGRSKYSPGWSWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PNA9</accession>
    <name>A0A2X0PNA9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C048g12348 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C048g12348</name>
        <name evidence="5" type="ORF">BQ5605_C048G12348</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000110">
        <property type="protein sequence ID" value="SGZ30400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="508"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="755"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="778"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGZ30400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1423" mass="154725" checksum="CA5A979DAAB53C80" modified="2018-09-12" version="1">MPPKSAPGATPQPGTSLEAAIAPIVARPPQQPASFAATELLRDSAGYQDWLLVVRSRLPAGVLRYLESGEPCTSWPPSLVPLWDHYALSSLCSSVDPRLVLPGLSTFLDDSDGAPKIWQALRSRYGATSAVDLLPAVVTLFSTEGLPATTDSFLQFRDGFENQLRLLTSSKVTVDSLVASHLLSRLPPSLESWRSTFVNDQGDSTTLPSVSAIFDRLLRDIRARPVDAPTAALARSSARDTRAPRTPCPNPKCRKMHWLRDCPDTAWAASFRARRAIENSNKPAGERKPSQPAASPAAAPSVADEHLSPAIYSACFLSASSPFDKGAWLLDSGANRHMANDVRLFTHLQPVKGPHVAGVAGSLPSTGSGSVALDTTSGRIAVADVLHVPSLPCNLLSVRRLDRLGFTVSFGSNVATIRNAAGTAVATARAIANDLYTLDLTPAPCRPHALLASPSHVSLLTLHNRLAHLPVLLLKKIVQKGMVTGVAWDYSDEECRTFHCNACLASKAHALPFARSTSIASQRLGLIHVDLAQMPHVSFGGHRYMLVIVDDHTRKHWCILLARKSDTFPRLRDWILEVERATGDSVKTIRSDNGGEFTLRSFVDFCCSKGIRRELTIPYTPQQNGRVERPNRTIKEGILALAYSAGVDSRLWGEAAMYFVRCKNMTPHAGINGDIPDARWYGYAPDISSLRTFGCRAWHCLPSPSRSALDPKAIPLIFVGLDDHSKAYRLFHPTTRKVLLSRNVLFRESEFPASTPTPALFSPANPLPDVVASRPDQADPPQPLLPAPPRSPVPRAEQLIPAPDASDQGSPALARNVPDQALPAPFASDQGGAPDQGSPDSAFSTPCPSPRLRPSSYDFSALCLAPEFSDDVDDALHSPAPVCYLADAAAALLDTSTVDPAELVAPARDPPHWRAAMASPQADEWRLAARDEFDSLSRDFSAFTPIDQSLVPADAKIIGSRFVFRTKRDQFGKVKSYKGRLVARGDSQRSGIDFDETFAPVAKFTSIRALLALSAARGYHVHQADIDKAYLHGKLDKPLYMRVPEGIALPGQVLQLHRSLYGLRQAGRIWNDEIDSTLLGLGYIATESDHCVYVKTVGDVHHYIALYVDDLLMIGPSLPEIERTLQGLERCYGVKRLGEAEYVLGIQIRRSSDGSITLSQEQYLKDILARFGMSNAHPVATPMISDLHLEIETNPTPFADRTRYLQAVGSLMYASTGTRPDLAYAVGYLARFSRSPSEAAWGAIKHVFRYLAGTLSHGLCYSHGDSAPVIGYSDCNWGACVLSSKSTMGYAFLYAGGAISWSSRLQSRVADSTCDAEYLALSHAGKEAVFLRQLFGELGLPSSAPTLVLGDNQGANALTRNPVFHARTRHIRLREHFVRDMVALGDVAVQYINTADMTADIFTKALARDLFARHRGRLGICSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PP55</accession>
    <name>A0A2X0PP55_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C052g12579 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C052g12579</name>
        <name evidence="4" type="ORF">BQ5605_C052G12579</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000099">
        <property type="protein sequence ID" value="SGZ29961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PP55"/>
    <dbReference type="STRING" id="796604.A0A2X0PP55"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042175">
        <property type="term" value="C:nuclear outer membrane-endoplasmic reticulum membrane network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039604">
        <property type="entry name" value="Bfr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027:SF2">
        <property type="entry name" value="LEBERCILIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027">
        <property type="entry name" value="NUCLEAR SEGREGATION PROTEIN BFR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015850994" evidence="3">
        <location>
            <begin position="37"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="415"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="534"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="546"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ29961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="570" mass="62649" checksum="B0ED44B8338BBBE5" modified="2018-09-12" version="1">MQVAPLFFFFPTLPSTLTLTLTPSLLSLSLCRVVGAAETKPTKKALAAQKRLASQPALSAVPKGQDPTLTTVDKPLNDKADHHSGRPDKSAYDKEQETLRAQIEALQLKSTDVRNRIAAASGKGPNQDRKVALRAQLDTLRAESQKLKGGRGSTFEQLKAMQDGVSNKIKELQAAKSKAPFKSVTEVDAQIKSLERQVESGTMKLVDEKKALQEISNLKKARKNVESFSTQQVAIDEERKKIEEIRATMDSPETKANQDKINEVRAELDEINKQHDEVSKGRDALFEERNAISKQLDEVYDKKKASALAYREANDKYYQKMHDDRQKRQERFQAERKANEDAKRNEINLRLLEEAQAPAFEREIEDCRNLIDSFNKRIGNVSSNGTLGNSTPLYERSTIAGVKALELRKVEEGPPAGAVALKKKSDQEEESWGGFGGKSKKKGGGNNVKKSTATNGAVTEGDTPASSSSSSSQALNLPFGTLSALLTLGIPAPLTLSDVPSTIEALETKKKYLVDNQDRVTKERVVAVEKKIKAAEAKSSSNGVATEEKKNQTEELTESSEKVEDALEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LNX7</accession>
    <name>A0A2X0LNX7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C011g06396 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C011g06396</name>
        <name evidence="2" type="ORF">BQ5605_C011G06396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LNX7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY12120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="488" mass="56044" checksum="B6AB416F7ADC55EB" modified="2018-09-12" version="1">MGSVLSSSATVQTQQHHISASSIAEDGRRTTLASRPTTSNSSNSMSHRIEEVQDEIRALHDAVRALPSTSRLSSSQKETHVLYNLQRRLEKMQYCLRHGVRDDDLDSYTPPPTRSNDRNDWNDFKTSRFFRCLLEKNGLEGKCSVCLPDSSRTCLLSITRRYSDRQIHHSDPYKVPKDFSALQAIGSRYWEQVKNSPELWGQWKEARASEARDRKETARPLKRWRIDSATISKLRRRYENAMNELVHEDSALRFRLLRGQYAEGYGFDALVIVSSNKLENKNDRFIVSTLGGAAFMRRQGWDSDQQKDILVNFTDCINGTRFNQEQNEQYKMRANHGDVDKASQRVLCAWYSITINDHYSEQPFHGSAPTFCSLVLNICGRADQALRRRHQRNRSTQPYVLSKLTSYNQATLAKDPIALIVEFGNGLQERDFRSPTNGKKPTVADLRRIIPLIGQDGLTFSLKEEIGQGSFDRTRAEVYCWCAYRALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LPM5</accession>
    <name>A0A2X0LPM5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C011g06616 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C011g06616</name>
        <name evidence="1" type="ORF">BQ5605_C011G06616</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LPM5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY12821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="125" mass="14167" checksum="D9FE5C48B97E026B" modified="2018-09-12" version="1">MSLLSDLVHLRTIEVSPLQCTAPEFRQRVKPRYIYSGPLLRNSPVSALDDVVDKCSLGQLVRSSINFSMDPLELFGAHHVKGYSRRNPLAEELSLQALLWSCDPHCNACSNGYVFRRQQAKRRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LQH8</accession>
    <name>A0A2X0LQH8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C010g06110 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C010g06110</name>
        <name evidence="9" type="ORF">BQ5605_C010G06110</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019783">
        <property type="term" value="F:ubiquitin-like protein peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="8">
        <location>
            <begin position="845"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="7">
        <location>
            <begin position="1157"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="1611"/>
            <end position="1647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="930"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1047"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1436"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1578"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="933"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="983"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1448"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1482"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1580"/>
            <end position="1589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY14227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1648" mass="185091" checksum="1786E1C290319D3F" modified="2018-09-12" version="1">MAPVALIMSTGEMSQLLQNKGGRPPIALQEQSSPEGYASEVDSEVDEDEDSLQVLAALVPVPSKSSISSPSAVSGLLIFPKSRSRDSDEDSADEGYYGVDDDNSDEKSIDNIFSALLLAWNDKKILDRHTYEPSRQDKELSNTTREAIFSNMILTTAEHNELRLRPLVLNCRKPRSEWEFVRKLPVLELPKFMATEKHDWAPRKYERCLAVVERPYGDAPSSTHHQHPSEVAVGIEWRPEVPITLREAWSQPGEGRPVAEVLRITHRCSGACKRVRVKDGKLGYKKRDNDKDPGKTCSTQLKILVQADDLSSALVYTLGNHEGRQPPPNVRRPAPFIRALAHQEVFRQANTPTLAFQNMNQRMKVGAKQLRNMFRAKGRQNAQHGSALYSLARTAELRPFTLQNATEPETRGVAYFQPFNEKTKQPLICVLASLHSIDVLISFATVGNDSGDWSRFVGLDSSWRYLNENRAPLTALVATGLKDKLALGPMLLSSDVKADTLVIYLDTVKRLVKERAAILVRKARENGPNLPGSSPRLPNLLQNAEFILETQWQPPNFMIDKGRTELNALTLYCSHDFEFLMIVVFCIYVTIGKEKHNLNFHIRLCQFHVVQTIIRWSSDRNDGERGNTVKPSRIARKTLINILYEFRSIIQRFRFIRTEHETDAEATARRSAEFEGKKRAFFEKSDAWIDEEFRSRRKPAANKSDVTKKSELGCNSREEEQLQAKKDNFRAYFNVNWFVQEWIDDGLPLGVSRETINTNNVTERAFKTIQQEHLHGRANKRIDNLVVVLPDNALVYDIWKDVSNAKPDHVLRDTLANSMDIWELGQFRPTEKEGQWVRSLRSMDSSITLDTRAPYCPCRAFKQTGNKCAHLWACDLLVHNGDYHTAMNRILAAAAAAKAMSDMRDGTKSSKLHNASVEALVDKVLDSKMPSALEDDNEPDEPLSEDELDERDEVDSDVEDEDERAADIADVAEFQSARNRPLQPHRSKKTAKPKLSKSKSNSGVTLEHSGRVDGKATAAIRRLIRDKLNPDQLRPKTSKHTIFENGTTQFGKTRGRPRETKFSNSLSSTKDHAAAKRMAAIPEVIDIEELSDDERPPCQLAPLQEGRLPLDIYDTVQPEERRSNVSAVKDIIKRIPNEVQKVDWDVFLDIHAGDHAPGLNLSSLREMANANLWLRASHIDAFSSAINRFQGQLPFNGRSKEVLDLEPTCYAFYLEGGKCAKGIGGTRPTERQQGVSSDGSSRAYLSIIIDRRPASLFALPLYQIILSRTPVLLFPTHVTNHWILVEARLSDCTFRVYDSLFGRENMRKEANESLDSIITFLETRAEGPIERITGGIDRPTVPYRNWKRLIVKAAKAGDQPQPDRYPQQTDGNACGAFVCRAMETLVCAAVAKMEPDWSWGPQVEPGRFYSELRDYMLDVTLHSRLRCDMSSSWFSGSPESPTVSCATRDPDNTMDSRKPHGNTQPGDHVGYSSDDAEEVSQHHISTPVSTRSVTFEGSRLARNVSSSADTVIIQHPQPGGLSHVGSVQGNNMSTARTRLASDQSDSPLNRPTLAFPSFSPVFATRDIEHLPKKCKYSAVPQESSPSAVVTPSKRRHSAAESVTPSSSRRKACSQCRDRKLKCDLGHPCSNCTKKRRGKASQVFTCEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LT54</accession>
    <name>A0A2X0LT54_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">BQ5605_C015g07910</name>
        <name evidence="17" type="ORF">BQ5605_C015G07910</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LT54"/>
    <dbReference type="STRING" id="796604.A0A2X0LT54"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051878">
        <property type="entry name" value="ZNRF_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNRF1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661:SF4">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0458">Lysosome</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="414"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="216"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="SGY17837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="652" mass="73649" checksum="516C9EF99845D465" modified="2018-09-12" version="1">MNAAQLQAKAIELSQIIPLHGNTIRWARNPHYEEHLMYTICQSGVIDVEDAQRLFSLRPNWSRSRTNEATVLGIVLENTFVSGTIPWYKIAESVKRRIKARTTEYLERTEMSRVDGERWSECLSRQRSNPGNLWFACMYDLLQDHAEFDVSRQIPGVVFLNMQRERQQDREVGAEALEEREMIRSTMKAELEHDLKQDQLQARREMAELRRAVEDIERTRRGEAQLQHHRARRDRAEQRRAPPPPPAAPAQAPQPAQVPAGNVVPDNAAAVAADRVRARPIDHDDPPVQQEEGWIKCGICHAVLPDDGGAMAEHLSTCLGTTEGTTMGSCPICDEAFASSMSTLAREQHVQACCDGGPALRGLGREHASESPLFHHEAILYLSMLTQTLLHPLVFAATSETIPRDSTTKQPQECIICLEDFEIGEDLARLSCYCVMHSNCIEEYWERPGTFCPTHRDDQPVRSSTMSQSCPGEVIMPFVGLQLALLLQGSHYRPLNKSSRISVWVRRAKSPGKPSLLSRNPFLRSRRRQRRRSQRRVRCLTFIICQNDLPSVLHLAPQRALSNPSHQRPPTYASRIQINQENVLCPRSDMSRDMRRVVTQGVVNDFGRGLPAADEELFGGGLARVEDGVESDQGFVDETFETFRGFTGGLSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LTI0</accession>
    <name>A0A2X0LTI0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="20">BQ5605_C014g07425 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">BQ5605_C014g07425</name>
        <name evidence="20" type="ORF">BQ5605_C014G07425</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY18646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LTI0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000007">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0229">DNA integration</keyword>
    <keyword evidence="16" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="19">
        <location>
            <begin position="609"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="18">
        <location>
            <begin position="874"/>
            <end position="932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="SGY18646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="935" mass="106550" checksum="FD62927B17EA3502" modified="2018-09-12" version="1">MHLLKLLRVELADRFPGDIPPVLMYESPVRHRIELKPGAKKPNLKGYRAPHRYRAPWKRLIDQHVTAGRLRKSSSEFASPAFVIPKKGMDKDPSIQPRMVCDYRVLNEGTVCDRTPLPLLDEILSICLKAWFWGKIDMTNSFFQTKMAEEDIPKTAVITPWGLFEWTVMPMGLCNALATHQRQVNEALGDLIGNVCFVYLDDITIFADTLEEHKRQVQLVLDALRRADLYVSPKKTELFAAECFFLGHQITREGIKVDPDKVQRIQQWPRPTTVRQLRGFLGLVQYLRKFINKLADLTAVLVPLTRKGAHVDDGWTGEHNTAFEAIKALVGSLPSLHPIDHSEQGDPLWLMTDASNRGIGAALSQGKAWQTAMPAGYWSRQYNLAEGNYAAHEMELLAIVEALHHWRANLLGVRFKILTDHHSLAGFMKQPSLSHRQARWTERLADYDFEIVYVQGPENTVADALSRYSFPEDCATRRASDDVNMLAEATLDPAFLKALKDGYLNDTHCQQAIKNIESTPGYSYKDGIARFKGRILLPKTGDFCKNAIHDAHNATGHFGLHKTYERLRWDFIWSGMKESCKEYVESCSVCQTMKMHGTGFAGRIHNLNVPDRPMREVGLDFVGPLIPSNGNDALLTVTDHLSGYVRIIPCRTTDDATTTADRFFDGWHRYFGMPWVLVSDRDKLFTSEFWRAYTGRMGTKLAMSTAFHPQTDGQSEQTNQTVIQVLRTMVNRQQNDWSKHLATVEFVINSSVNRSTGKTPFEVADQSNKVRKLEPEFAVGDRVLVDSRDRRLRYKADGEARSAKFFPRFDGPYEVLAARPETSNYKLKLNAGDKSHNVFHTSKLRHWTDNDGVAFPGREATEPASVVVQGNEEWEVDRIVDEKGKGKRKRYLVKWKGWADSDNTWEPRAHLEETIVLEEWERERAEGERGKEGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LTX6</accession>
    <name>A0A2X0LTX6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C014g07418 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C014g07418</name>
        <name evidence="1" type="ORF">BQ5605_C014G07418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY18632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LTX6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY18632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="226" mass="24445" checksum="40A6B6E3BA7BDBC0" modified="2018-09-12" version="1">MDTSSPLTTGAHPTIPAEQLAALTSLLSGLTTATSATSSGTSRTAFPKHAHLDGPKTFASWTRQLRLCLADDIRSYVLDGIVPADWTPSHHSARDVVACELLANSIDSADVSAVLDQIPTADLTAPKIYSTLKSRYAPDDATRTLELFSRLWSFRPMPGTVGEFDGWIMEFKAIAQEIINTKTVRAPDFGWADLGPAKWPHSGFSPAQATSWSGLPWSFDQRLTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LU34</accession>
    <name>A0A2X0LU34_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C010g06198 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C010g06198</name>
        <name evidence="2" type="ORF">BQ5605_C010G06198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRM112 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LU34"/>
    <dbReference type="STRING" id="796604.A0A2X0LU34"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039127">
        <property type="entry name" value="Trm112"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773:SF0">
        <property type="entry name" value="MULTIFUNCTIONAL METHYLTRANSFERASE SUBUNIT TRM112-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773">
        <property type="entry name" value="UPF0315 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY14486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="163" mass="18633" checksum="40668042F3DEDB3D" modified="2018-09-12" version="1">MVRLITHNLLSCPSKLCSYPTNFPLQFRNVSRIELIDQDFNEDFVRGFLSRLEWHALCTSAQQLGDTSLPTERPDFDDPQAVPLDLIQKLHHVLLEVSPTINPYEKRENPKTLALKPLTEYSSLHQIVVMDGEMVCPSPACGHIFLIKDSIPNMLLAEHEIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LWK4</accession>
    <name>A0A2X0LWK4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C012g06792 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C012g06792</name>
        <name evidence="2" type="ORF">BQ5605_C012G06792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LWK4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="465"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY16174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1226" mass="138039" checksum="DDF3ADA1F2B26F63" modified="2018-09-12" version="1">MVVTAWIGKKARSFYWIVFCRLPTAQQPALETQPRRDIRRCRAQLNKKTDDRRDFFGLLHFNAPRPKTLRILAGDLNDCPDVSVDRVSITDRAWTPVSHWQTLLSKIAFNALDTVRHVHSCTPAFTRPHYRGRGEERKICSWSRIDYILVQCSWANRLLSASTLFDAPCSDHRPVVATFALPTSNADAEPPLSLPSTSDFISRLNPTVFDDQDFVASIPGVVDEVYRRLEGTAPLGDIYDAALRAVAVAGHARYRSTRADMRRLRAESQSVMEALEARGEHMNEAERDAYAFAKSRLDQLAVKEAQWLRIRAHVPSVDSREGQSASIRTRLNRRSRQTSIVSLEDVDGTETVDMQEALGIASRHAQSLFTPDPARGDPTNARRSLLDPIRAAKCYDDDRSDPTFGRRLPRQARVALDEPFTLLEVEAALKKTDSGRSPGPSGIPYELFKALPTYFAPKLLDLFNSIWEGGKMTASLAEGLVRLLPKNKPGANLKSLGAYRPITLRETTYKVLSKVLVARLNGVLGELLPPAQHGFMPSRRSADAGSHLTLLLEKLKSLGTEVFPEGALLSLDQQSAYDRVDHAWIFDVFEAFGFGERFISLLRALYDPETLGVRYLINGFPTELVRLLCGLGQGDPLSCPVWNITFQPFLDALVRRGIALDLQKVWPGGPRAQLTHLAFADDAVVVVESPAALSKLETLSQTWYEATNGKTNTDKTLVLPLGPNWLRDETAQALPTVQEGESFKWCGYAFFRHGDSKLFWTHVLDRIKAKTRAAGDRTLSPSGKVFYANAHIISTVLHVLSFDIPPQWFIKAAETALTDFVWGGAGRNTVARDFVFQAREDGGLGLISIGDIVHSVALRFWDAVAGSNEAIWAPLARESWRSLVAATRDFSPWGFFSSTARVEKLYRDSARWGAVVAAARVTLPTIKSELLTLPELLSLPPRLPSLYAEGAKHAYDDADAVAKFAQIADLYWRDEGKGWALVGHRRGFWQHSKEPALQHEHVWSRVGQLLKAKALLPKTALRPARIPLKEAPRPRCFNFFGLTRPFTIRKLRRLVNVVRFPGREDRVKRFRDGTSQSDRKRFWRWLHDRFASAVEQDTHWRLMYDVTPTRKRQHTQGHASSPTCLFCGNDAAVIETVSHYFFECAYSTSFWGGVLRILFDKLGIEDTDVDPSTFTPEQLTMGLPLLRGRGRTTSKWMWVRLACAIGFQRLHLLRWHVHQRFEKVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LWL4</accession>
    <name>A0A2X0LWL4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C012g06802 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C012g06802</name>
        <name evidence="4" type="ORF">BQ5605_C012G06802</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0507 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0LWL4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097422">
        <property type="term" value="C:tubular endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051248">
        <property type="entry name" value="UPF0507/Ank_repeat_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24170">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24170:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G09870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="3">
        <location>
            <begin position="1060"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="345"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="581"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="644"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="750"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="815"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1051"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1226"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1364"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1455"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1622"/>
            <end position="1644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1681"/>
            <end position="1743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="360"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="581"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="597"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="656"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="750"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1253"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1461"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1681"/>
            <end position="1694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1695"/>
            <end position="1716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1717"/>
            <end position="1743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY16204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1743" mass="186742" checksum="C8CA6976A9D07893" modified="2018-09-12" version="1">MTSAILSSSQTIPTPAQYSPQNPTNANAVAGPSNLHQHHPVRSDLEQLPGSDDIVDAMPTSTTNNTNTTYLTRRLSRSRPRTSFHARSSSAENQPPPPIRSSPSKACLNDDSAPSGSSYRFPLAKISTTLEHLPPLDQTAASSPLADTSGLSDGEPLIAHLDAIALERDRLGRHRLRTNSSEQRSTPPPTSPREMLDFADFVSETFRLQDSSAQETNAGAGTAPMEHHIDGGVDYLIPMQRGSFQLAEALTPVQNHTTYQFPRFETMSSLPIFPDMVPRTPRTSSLHATDLQRLISSQSCDGRSIDLIDFESPSRKSLVVTTGSTPSAASTISTAVELSPLHTAHQLSDHGPNSAPPTPSSVTGSLTNSIPFPGSAASRTIPLPSIRAESTDPHEGEVEASSDDGHPPPMADHSMDDNEEALDDEEDAEDLTEDEEDEDPDSHPLYVLLSSSAIPVLRSAWDAATLILVPPRRTLPSLEALTPRRQSAAPAFEFVRGGKGVAGEQAGRDVEKERQMSITYVALHAFKPLENDEDAAPGTTSWRSVIASEEGHCRARLIPGQGTALIDWVEMPGPTQVINSAQSTSSFASSGSDNGSKNESTQARSPRSPTAAVVSPARSSFSLITPVKSLRIIAETTIYRRPRQIISATNPPPAPSTLSASTNSTLGKSSGSSSLHKSGFRTPKWFKRSISSAIPTLKTWPERTDADLNPPSFVTPTLASVRETSKSGPMLERVRVLALGGGIVMRRGSISASTTSQRRTLHGTSVPSDPEPIIRTSASSISLRLFGTDSPHDSNNRSQSSLALSRHPTFELVGETTSSQGHGAPSTRRRAGSMSSTRSARSWRSAFGIVAVGANGMMRGEFLADLAFLASPPPQLAGLAPVFASTLEYIRALVREFEGGVAYIRGLEPYLIQRIRKGIFDRIWQQIVRDLDADEELRTWLVSEEHATNLRLLIENVIIGLLYRKLYTSSILPHFSPEDATLNSIISTYQERQVLPTDLGVHFESAEPLANGALKTAITILQDLKETSEVATKVPDKVAQLWVLSAATLTTRRPGPASTSGRDDRSKSPSPSPASTAGPTIQKPFSITDAGAATRPLRGVRTPLGCVTIIAESLQAMVHAIETLQGGSRLAPDDLIPLFSWVIVKAGVENLESLLFFVKTFRLSESLPSHLDWSFVNFQAALAFLLSDPLHCLPEPPAMSTPTPFFGIKSADASTVARTRRLSLQQYRPTHAGISPPSSPKSVRGTGAGWYSPGTTSVNREQSTSPTASLPFPNYARERRLSWQQASKAPKRVSVTLDADPMLPPRSDRLTSAEEMPPPSWKLPPSSRNRHHVDSGDSVTPQSETSEDGDASAATRHLRALSLASLSSEGGTPDSRSRLALPLEGMSRDRIRVPSLSRSYSALAMMTRPPAGGGGDMSFGLSSTDMRRSESEGSPVVPDRSTYADRWSLWGALPSSTTTSNAPSSQRAVSPFTSENASGQAPPLSYDAHSQSWWSWGGGLSAGALYPTSQLAAPLYPVANDASTHLRRLRRFSASTAEILAERPAHLVDQVVSQSNSSSSIRLAAILQNKTSETDMLPLARPRPRSTMSVSSIGSNASFVLSSESEETSSVPAAALASTLTPSIVAPPPPRRKSTRSRTWRELPTSNLAGAPLAPCLDSTSIVSIPRAEVFASIEANLVAPNPSSNAALSSNEPRSSFDTSRSVSFELTRSPEGSQPTSPCLDDPPTTTTTATTSTLTVPLMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LX86</accession>
    <name>A0A2X0LX86_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C015g07879 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C015g07879</name>
        <name evidence="2" type="ORF">BQ5605_C015G07879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LX86"/>
    <dbReference type="STRING" id="796604.A0A2X0LX86"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF108">
        <property type="entry name" value="PROTEIN CNPPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY17757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="412" mass="44410" checksum="9BFFCE109CA0F06C" modified="2018-09-12" version="1">MSIQVLQSFGPQARGHLSLSFCTFPDFANSTDDCRHTRTHTRFCGSISMPSPSSRGVGGVGGARVKPNRAPSAGPTPWTDRLLTLPGEVLTCCVERLLTHAVEANEALRPSCKGTITRFHAKEPPSLALQDYLSRLIVYMPCPRDAILLTVLYLDRISRLRPPAPYHEVTSVPLLPTVEVGQASKEESHEESESLAHPLINTFTIHRLVLAALLVACKSECDGHLSQRRVAKVGGVTMRELIQLEVDVLALLDWRLTYTLNAVEDLSRTLWELAGKEGLITAHADDPSPISSSSAPSVAEVTAEASVGPRLQGVPLVSVSTANSHESDDRISIISTSTASSASVSPCMRSPARDSSMSPSPPSSNEAFTRSSLEDSRQSNASEKNSTSLQGRRLGSRASSETVRRLDRPSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LXR6</accession>
    <name>A0A2X0LXR6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">21S rRNA pseudouridine(2819) synthase</fullName>
            <ecNumber evidence="7">5.4.99.43</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Pseudouridine synthase 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Pseudouridylate synthase PUS5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Uracil hydrolyase PUS5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C002g01116</name>
        <name evidence="14" type="ORF">BQ5605_C002G01116</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Pseudouridylate synthase responsible for the pseudouridine-2819 formation in mitochondrial 21S rRNA. May modulate the efficiency or the fidelity of the mitochondrial translation machinery.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>uridine(2819) in 21S rRNA = pseudouridine(2819) in 21S rRNA</text>
            <dbReference type="Rhea" id="RHEA:42556"/>
            <dbReference type="Rhea" id="RHEA-COMP:10113"/>
            <dbReference type="Rhea" id="RHEA-COMP:10114"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.43"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.43" evidence="7"/>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY30087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LXR6"/>
    <dbReference type="STRING" id="796604.A0A2X0LXR6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160143">
        <property type="term" value="F:21S rRNA pseudouridine(2819) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF81">
        <property type="entry name" value="21S RRNA PSEUDOURIDINE(2819) SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="13">
        <location>
            <begin position="97"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGY30087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="362" mass="40382" checksum="307BF586E365C26C" modified="2018-09-12" version="1">MPSLILHRSLSTIKPTRSRPSKATPRKNTFSAFSPQTTRARPPPSRAPPPPPYYTGSRSSSRPAATAAPPQRADRWKTVNISLPRPPLPKLLYQDNNLVVIDKPSGASLQGQYGTEARLNWEGILKALKKRIDSGNLNPVHRLDKATTGTLILSKNAQAHKNLCSQLTRHEISRKYLAIVHGRLKPGYRDLIYAPLRVDQDRVRMEHEPVTDLASEELGKIIEAKTEWECLASSSSNLSLLLLSPQTGRKHQLRVHCSQVLRAPILGDHKYELDPDTMMSSALATDLPPSMMGANGSMFLHAWAVRLHVWDKNTGKRKTVGATAPLPYAFRRLIKKMGWKEPTTESISWPEGMKELSLIEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LXS9</accession>
    <name>A0A2X0LXS9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetylglucosaminylphosphatidylinositol deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C014g07494</name>
        <name evidence="3" type="ORF">BQ5605_C014G07494</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIGL family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.89" evidence="2"/>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY18853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LXS9"/>
    <dbReference type="STRING" id="796604.A0A2X0LXS9"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000225">
        <property type="term" value="F:N-acetylglucosaminylphosphatidylinositol deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993:SF11">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY18853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="325" mass="36029" checksum="78CCC0B4CED890B4" modified="2018-09-12" version="1">MGLGDKLSVIAVATLAVWSMLLASNWTNRTPHLKGLKEAKSIIWVIAHPDDEAFFFGPSLTNLLAPPGRDEEKSKTVYPTGHILSLSSNYEGRGEVRTAELKESCRMFAVDDDNCVVVNDPRLVDGPDQTWSVDVINSIVAEKVKQWNADVVCLLSHSPNLKRQGLNSDRSLQIITFDPLGVSSHPNHASLGQTLLAAPSTFPQIYLVRTTPLPLKFTSLILLPLKHLQHNIIPSSLIPFLPSLPGIGAIASPSPRTVFLTSPPPSFILTRLAFDAHQSQQTWFRTLYALFSHYLWWIELVPREEYELTRAAQVGRLIGEGKTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LY35</accession>
    <name>A0A2X0LY35_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C014g07624 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C014g07624</name>
        <name evidence="2" type="ORF">BQ5605_C014G07624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY19345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LY35"/>
    <dbReference type="STRING" id="796604.A0A2X0LY35"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY19345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="235" mass="26059" checksum="00F87F6938933B53" modified="2018-09-12" version="1">MSPAPERIRTITLPSPFTSSESTDAPEPLSLHLSRKAASYLLVHSASGDTAPHQYSIINCLASSDPFPLPDEDNQRCRMWLKIGPRASGEDGGENHGLVEHLEQQAIIRDTGIKSQQGEISQPLVELLLDEKELSHVCEGCGKFETASAESSSEDGEEESVPAEDRFKRCARCKMAYYCQASHWKSHKLNCQDCIAETDYEIELARRQILLKVYGRADHLSEADEGQSAKKSKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M0U7</accession>
    <name>A0A2X0M0U7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP citrate synthase</fullName>
            <ecNumber evidence="5">2.3.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">ATP-citrate (pro-S-)-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">ATP-citrate (pro-S-)-lyase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Citrate cleavage enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Citrate cleavage enzyme subunit 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="primary">BQ5605_C018g08739</name>
        <name evidence="29" type="ORF">BQ5605_C018G08739</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="23">Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate in multiple biochemical reactions in protein, carbohydrate and lipid metabolism.</text>
    </comment>
    <comment type="function">
        <text evidence="18">Catalyzes the formation of cytosolic acetyl-CoA, which is mainly used for the biosynthesis of fatty acids and sterols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>oxaloacetate + acetyl-CoA + ADP + phosphate = citrate + ATP + CoA</text>
            <dbReference type="Rhea" id="RHEA:21160"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.3.3.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="20">Composed of two subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.8" evidence="5"/>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY26479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M0U7"/>
    <dbReference type="STRING" id="796604.A0A2X0M0U7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003878">
        <property type="term" value="F:ATP citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06100">
        <property type="entry name" value="CCL_ACL-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000003">
        <property type="entry name" value="ATP-citrate synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000004">
        <property type="entry name" value="ATP-citrate synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000005">
        <property type="entry name" value="ATP-citrate synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.110:FF:000003">
        <property type="entry name" value="ATP-citrate synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000024">
        <property type="entry name" value="Probable ATP-citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032263">
        <property type="entry name" value="Citrate-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056749">
        <property type="entry name" value="Citrate_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118:SF42">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16114">
        <property type="entry name" value="Citrate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24948">
        <property type="entry name" value="Citrate_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-citrate synthase ATP-grasp" evidence="28">
        <location>
            <begin position="92"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase citrate-binding" evidence="27">
        <location>
            <begin position="330"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="CoA-binding" evidence="26">
        <location>
            <begin position="578"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase/succinyl-CoA ligase C-terminal" evidence="25">
        <location>
            <begin position="743"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="526"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="541"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00054002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00060724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00062455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00076189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00083544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00093367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF02629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF16114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF24948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="SGY26479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1191" mass="129612" checksum="174E54EF5F97F22F" modified="2018-09-12" version="1">MSAKPIREYDAKLLLAYHLNHAAQFGTECTVRPGWKAPNTRVAQLPRVGKRDRRSCSLSPTRVDSIICHEADHALRPTMPSELVQWDPAKGDVTRDEALPAWVFTDKLVVKPDQLIKRRGKAGLLALNKTWAEGKQWITERAGKQVQVEKTTGTLNTFIIEPFLPHPADSEFYICINSVREGDMILFTHEGGVEVGDVDAKALTLLVPVGGELPARDTIKAGLLKDVKTGEVKEALVDFIARLYSVYVDLHFAYLEINPLVAVEVEGKTEIYYLDMAAKLDQTAEFIVGPKWAIARDPSIFNPQAVAQKVTGKTLADRGPAMVWPPPFGRDLTKEEAYIAKLDSSTGASLKLTVLNAEGRVWTMVAGGGASVVYSDAIAAHGFAHELANYGEYSGAPTTNQTYEYAKTILDLMTRGTPRSDGKLLFIGGGIANFTNVAATFKGIIAALKEYQHKLQEHKIRIFVRRGGPNYQEGLKAMRLLGETLGVEIQVFGPESHITTIVPLGLGITKTAASLESLAPEIPAAGTLTPVAPSSPSGKSAALPAQPPRQQAGARDGIVSFDSIPVDGERPWFRPFDERTRSLVYGLQPRAIQGMLDFDFACGRETPSVAAMIYPFGGHHVQKFYWGTQETLLPVFTSVAEAVRKSPDADVVVNFASSRSVYSSTLECLEFPTIKAIALIAEGVPERHAREILHLAQKKKVTIIGPATVGGIKPGCFRIGNTGGMMDNILSSKLFRAGSVAYVSKSGGMSNELNNILSLTTNGTYEGVAIGGDRYPGTSFIDHLLRYEADPNCKMLVLLGEVGGIEEYRVIDAVKSGQIKKPIVAWAIGTCAKMFTTDVQFGHAGSMANSDLETAEAKNNAMRAAGFIVPPTFEDLPRALKTTYEKLVADGTIVPKPEVAPPTIPIDYKWAQELGMVRKPAAFISTISDERGQELLYAGMPISDVFKEDIGIGGVISLLWFKRRLPPYACKFLEMVLMLTADHGPAVSGAMNTVITTRAGKDLVSSLVSGLLTIGDRFGGALDGAAAEFSRAMDLGLSPREFVDSMRKANKLIPGIGHKIKSKTNPDLRVELVKRYVHDNFPSTKFLDYALAVEEVTSAKKDSLILNVDGAIAVSFCDLLRYSGAFNSEEAAEYMQIGTLNALFVAGRTLGFIGHHLDQKRLKQPLYRHPADDIFITPFDQTRVLVTQRHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M0X6</accession>
    <name>A0A2X0M0X6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">BQ5605_C018g08769 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BQ5605_C018g08769</name>
        <name evidence="16" type="ORF">BQ5605_C018G08769</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY26745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M0X6"/>
    <dbReference type="STRING" id="796604.A0A2X0M0X6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="15">
        <location>
            <begin position="67"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SGY26745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="469" mass="52746" checksum="1FA266C8E6DA8506" modified="2018-09-12" version="1">MVAGNGDILFTGQKLNLGLYRLELKLVQGQSAPLDCALNMKSRSDFKCKSCLAGKATHNPFPNSELRAGKPLDLIHIDLLSFDGELSLANHRYALVIVDDCTRYMWVLMMPRKLDSSERFKTWKLRVELSSGHTLKVVRSDRGGEFLSTEFKQWLDDTGLLQQLTISSTPKQIGVTERANHSISEAARTMLYESGLPMVFWAKAVATYKKPAHVHHLRVFGCRAWHTANTEQRMKLQPRGLPMIFLGYDLESKAYRLWDPVRARLTLSRSVTFFEDKFPACEGVPAPRKPTREAIKVVVPQPVATNCHEAEQQLIAAAPEVEVHAREENLVDNVDPAEQRGQVVEDVPKELRFEASRPAWAAPVGKRDCRAPERFEPEAFAAIANSNKEDGPFVLPTSDPTTWKAAMAHHKSHKCAQGAINEFESLHDDYSVFTIMKRDELPAGAKVLGLKFVFPTKRDKDGWPTLYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M160</accession>
    <name>A0A2X0M160_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C083g12989 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C083g12989</name>
        <name evidence="9" type="ORF">BQ5605_C083G12989</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000034">
        <property type="protein sequence ID" value="SGY28158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M160"/>
    <dbReference type="STRING" id="796604.A0A2X0M160"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase RNase H-like" evidence="8">
        <location>
            <begin position="117"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="229"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY28158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="282" mass="32239" checksum="C35697C0DAE4DF38" modified="2018-09-12" version="1">MTLRHYRFYLGSNKSEWFSKSLDSLGAIISDDGIEVDPATFPRHRELDARSPAHLSITLEPITALLAQSTSWRWNEHEQQAFDTVKSLVPATLRPIDGAKVTSGEHKIYLFTDASRAVPTRFFSAKFNGAQLNYHVTDKEFLAVVSACRAFEQHLIGYPFVIVTDHQALRTIKTQKLRQTPRHIRMCLELSRFDFEFEFHCGQEQLPCRFDQVKENELEDMFFDGERHGFTTHGESLPEERPYTSPSPDRLPPVDLPSGPTDDCEAGSPGYYALKTNRKTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M1N9</accession>
    <name>A0A2X0M1N9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g02455 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C003g02455</name>
        <name evidence="1" type="ORF">BQ5605_C003G02455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY40983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M1N9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY40983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="54" mass="6213" checksum="4D4894678075A62E" modified="2018-09-12" version="1">MAREGRSLVSGQYPRVKARLVSLYWIAFLLAPTAQQPALEIQPREDIRRCRGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M2B7</accession>
    <name>A0A2X0M2B7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C002g01352 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C002g01352</name>
        <name evidence="1" type="ORF">BQ5605_C002G01352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY32345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M2B7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY32345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="92" mass="9964" checksum="A888296E4DD32FAF" modified="2018-09-12" version="1">MFDHALSTYCSVTIYFAPPPSMGLFRAGYGRGSDGLWGVCCGRQDWRGFIAGEAHKMSKYGEGVHSLGLDDGLGLGLDQARSIIMHHHDSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M2J0</accession>
    <name>A0A2X0M2J0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C002g01432 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C002g01432</name>
        <name evidence="5" type="ORF">BQ5605_C002G01432</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY33000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M2J0"/>
    <dbReference type="STRING" id="796604.A0A2X0M2J0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040155">
        <property type="entry name" value="CEBPZ/Mak21-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048">
        <property type="entry name" value="CCAAT-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048:SF0">
        <property type="entry name" value="CCAAT_ENHANCER-BINDING PROTEIN ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="765"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="domain" description="CCAAT-binding factor" evidence="4">
        <location>
            <begin position="698"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="534"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="540"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY33000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="937" mass="102235" checksum="13A5A8D9CF43AE93" modified="2018-09-12" version="1">MAPNPYIKAVAGTNGTSTTKKAKKPKSTQTKPAHGAPAVDSSTTTNDPTRDALRREVLALGGDEDELKMLLDVDSESEVEGEDIAVNGAKAGKGKGKGKDVVDPALSKELRSLFKTLDFGSVGGPDAAEEAEEAAEEEGVDQESDENEDDDEESSSDSDEERDEDEAAAPEPEAKSKSSTTAQSKVAADPAAAATKKEFKYEREERRKIEREAEKEREKAEKLVEREAKHSAALTPTIKSPWLVDPTPQWYAVPLAAIQPLTTKPSRETITALASRGEALLARENEIYSSSLSPSSKGSALPPPNGLSKADQVFIQQILTSGTSSDKVSALLLLVSSSPLHTMSYLEQLATLCKKKSRDESGRAVRGIVEWWRGDGGDGGGSPSRKLRTFADQPLLDAVARTLDASESGKRNAPLPQGVTKQDLERTLALFAFEDWLKKWFFSILQALEQMSTDPLPHPRSLAVVHIANLLRDKPEQEGNLLRLLVNKLGDSQRGIASKTSHHLLQILQVHPGMTPIMVREVSGLILRPNTPAATPVADSSKKHLRFDSGDKTAAAPAVKSKAKDNGHDHARYYGVITLNQIMLKKDQSEVAGRMIEVYFAIFGDVLGRVTEDNEEGAEVDKTTKALQGQKRKRGATGMEAAVVQAEGEVDETDSKLIAAVLTGVNRAFPFAKIEDDAFKKRLDTLFRITHSGTFNVSIQALLLIYHVSAAKKAVSDRFYRALYASLYDHRLAGSNKHALYLNLVFKALKQDPNRERVMAVIKRLVQLVLLMDVTFILGALFIVGEMMATTPGLRKMLAEPENLPSKLEEAKKTPQSETAPALTLESIAYDGRKREPQFAHAENSCLWELVPLLNHFHPTVALHASMVLSGEPLSASDELEQYSLTHFLDRFVYRDAKKTASTKGASMMQPGLASQDKSGRIIMRKGTGVVEINSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-05-29" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M398</accession>
    <name>A0A2X0M398_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C002g01591 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C002g01591</name>
        <name evidence="1" type="ORF">BQ5605_C002G01591</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY34115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M398"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY34115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="236" mass="26171" checksum="12C76AE134794879" modified="2018-09-12" version="1">MTAIVPYGVVYPEKYHADRKAAAEIATQLGFKEETFIEVTVQWGDQDPNVHLNNAMYYKYLEAGQCLTARKPHSPSLPTGRGAYVRSITRKLDAPTAKAINQGAQGRGLVVGQVMNRFERPVYAPDHLLIAHRATQVAKKKFVLTSVIVSFELSSSALQKPRYRLAWVLIATSRRFLFFLCSQRARVCSGEAIMVGFDYDNHKGAELPNGLYPLIEREISDAAQTIAAAQGSKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M3F8</accession>
    <name>A0A2X0M3F8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BQ5605_C002g01530 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C002g01530</name>
        <name evidence="12" type="ORF">BQ5605_C002G01530</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY33706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0M3F8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="470"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="549"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="576"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="607"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="717"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1158"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1188"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1249"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1276"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1310"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1429"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="103"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="808"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY33706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1493" mass="166501" checksum="6F2D45B94B118EEF" modified="2018-09-12" version="1">MASPTVDHASSPSDTNEPSTSASNQRAPVVDPLPHGLPIRFSRLSVPSSSSPLLGTPAGGGTSEALVATLGSAMIDLISLGPVRRVVRSTINQRRRAQEDPGTTLSERERRDRTRSIVAGVEGVVHQGEMLLIVGPPSANVSTLLRALSSPSDLPISASSHLDYGQLPPATVNRPSIIPPYPANAGKLRSQVVYMNDHDVHFATLSLRNSMLPGSLAKTPGTRARLDGSTRRQWADSQLNRHVDAMGLSHAMGTKVGSSVVRGLSGGERKRASLVEALLTRASVLLLEAPTSGLDSSTALSVLTYLRNWAKRGKRSIVATAPHIADPLYFQFDKVLVLSSAGRQIYFGKASDAQVYYETLGLGFHRRTELGEGVAEFLVACNEGRGNDVVLEKAWIKSEARQQVANEIADYDKIYPLEECAQPLLKALDLEKSRTTQAHYTVSFLYQVLLLTRRQYALVYSELPGYVTKTVVNILLSITVGTLFFRLPSTSSAAFTRGSLLLLSIMFNAYLSLAELGKAIEGRDIVRRQGDWGFFGSSALALARVASDIPLIFAQCLLFGTVTYLMAGLQSTWSHFFIYIIFVNATALNLSSMFRMFAAFSPGFEEAIRFCGICLNILVIFAGYFIPTPSMRKGLKWIHYVVDPISYSYEAVLANEFHNLSLSCSPDDIVPFGPTYTRPEYQTCLLAGSTSGSLTVSGDAYLAISYDFHYSNIWRNLGIMAAQALVFLVIGVVATEFLHFAPGGTKRVWARTKRVMKRLERANRWYKQRKSDEDDYGVDLVPMFEEDMDEDEDELIRQSQGVQDGSTLMWKNVCLWVDTESDTRRLLDHVDGYIKPGRVCALMGASGAGKSTLLNVLAGRTVGVVRGIVLVDGIPPDEQFYRTTGFCEQFDLHAQIMPPFRADERSTIREALEFSALLRQDASIPRAEKLAYVDHVLELLDLTSIQDAIIGTPSEGLNAEQRKRTTIAVEVVSRPRILYADEPTTGLDSKSALKVVKLLRRLARTGLAIICTIHQPSAETFNVFDDVLLLQRGGRQVYFGPRDESIAFFASLGKESTHQNPADFLLDVAGAGLASTDGEDLNNEPFVEDPPPDQNVALKWKDSRECDQLAEELDTLCAAPKRLRRKVAVPGTWFECVELTKRVTRHYWRDPSFSYTKLFTSTIVPFVIGLSFFRVAQEYSIVSFQNRLFSVFLLLFVPVVWNLLYLFYRFQNVIIFKIFKLRGLWEARERPSKIYGRTAFVTSLLVSELPYSLACATLYFVIWYFLVGFPLKSETLGFAFLMIQLFYLFQSTWALWIVSLSPDIGTIANLLPFFLVSMEAFNGALMPYSQMPRYWRWLYYVSPFQHYVQSMLGNLLHGQPISCLPSELVTFESPYSVSCVDYMRTYLRENAGYLTNPASTTTCSFCKFSNGDDYMATLNIAYQDRWRSLGVLFVYTITNVIIAYGLVFYPVPWGKVLFWRQSGGRQHARAEMAATKEYEREVAEMLTATTLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M4D2</accession>
    <name>A0A2X0M4D2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g02144 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g02144</name>
        <name evidence="2" type="ORF">BQ5605_C003G02144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M4D2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY39104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="205" mass="21603" checksum="6740D2AEAF625BF1" modified="2018-09-12" version="1">MSAVTSNPEVPQTQVPGLTNGVDSSAPIETSSAAPINPARDSRKVTDIGSNAKSRSGSRQRLTDAVKSVFGSHGHDLNFADQHGLERKSRDASRSASRPGSRSASRTASPSRVSKVLGSHGHDLNFANEGLERKGRETARASSKSPSREGSRSRNPISKILGGHGHDLNFADTAGLERKSRNASRAGSRSASRAASPIREVQSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M574</accession>
    <name>A0A2X0M574_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g02454 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g02454</name>
        <name evidence="2" type="ORF">BQ5605_C003G02454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY40978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M574"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY40978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="287" mass="31480" checksum="60D6F739967DC08D" modified="2018-09-12" version="1">MLVDLGTISGDVIPLNELREWEQVLNVVVNLEECNGHLRDRGTWKGFYAQIVDILGEERGKALLSMVLHVDDFAIKTVLMEQLPEKYTFAFREEKDVDLFLEKVRTAYDEDVIMNGANDKEQTEAPASALAAARQEADPGQAPPCNGNCACGQQPHAFATAGQHRGHAGPTRNSYRSGGHGRTGTRMGAKTRAEHYANSDKWGKIVDGKFMCANNQCVNCFGFGHRRAACDSRNPTGDRIAFLQSLDVNVPVASHGTYFVEDPVPMSLANPMDDFSRSDGRGSGVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M5P0</accession>
    <name>A0A2X0M5P0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g04006 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g04006</name>
        <name evidence="2" type="ORF">BQ5605_C006G04006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY55337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M5P0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY55337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="81" mass="8708" checksum="D74A1C2F285AD7C6" modified="2018-09-12" version="1">MAPHPNATSSLRHLKGSSWKLCNEYGIKKIVQKLMEPYQAEIPFNASSLNVNPRDVPSPSAGDTACTLDVSDTAEGLTSYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M7L7</accession>
    <name>A0A2X0M7L7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00477 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00477</name>
        <name evidence="2" type="ORF">BQ5605_C001G00477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY46869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M7L7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY46869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="143" mass="15843" checksum="9B55C84CA99FEF08" modified="2018-09-12" version="1">MRFPRPSLPRRHYDTTVLNVGLTNGLTIGRSVLHHYPGYLVPTEPSIPKNSTQPFPPVYGSQRWSPYVRGPHRVSQKSAQAKTAPPASHRLHLLPLHCVSATALANAPAIEKHQRHRSDITLGHREPKSPVGVGEFDETPKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M7Y9</accession>
    <name>A0A2X0M7Y9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C001g00618 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C001g00618</name>
        <name evidence="4" type="ORF">BQ5605_C001G00618</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY48138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0M7Y9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033596">
        <property type="term" value="C:TSC1-TSC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11210:FF:000007">
        <property type="entry name" value="Tuberous sclerosis 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018515">
        <property type="entry name" value="Tuberin-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027107">
        <property type="entry name" value="Tuberin/Ral-act_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024584">
        <property type="entry name" value="Tuberin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063:SF0">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11864">
        <property type="entry name" value="DUF3384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03542">
        <property type="entry name" value="Tuberin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="3">
        <location>
            <begin position="2004"/>
            <end position="2243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="267"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="383"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="494"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="968"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1026"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1271"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1408"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1026"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1275"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1425"/>
            <end position="1438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY48138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2278" mass="248505" checksum="FE09B3E086DD1CF8" modified="2018-09-12" version="1">MSFILLLFCDQSFHVPRYICVYSTLALCNLRYPDRVVCAWDGRARRCRIPGCASPGYSTSDQLVGASLERIIFETHGFNSSSRGDGIHSDQLPTGPTDHWQTAPGSRLILGRHSAPLLPLATFLSDTPTIRAPSLHTVCTVGPGDLKAKEQLCSPFCSKPSTSLCERQLEVLKAYWWTRRGDRARVQLRPRTGRCVVNMPPFPLSTPDPNRSRLPATSASSQGSTSSPTSSAAPSDTSSSGGGGNQFISFLTKVGRGLGKASASGAEASATGSASTSPSTLPPASRSHFVAVRPGSDGLEGFGGRAVSTGSSSRGAGVKLSKSKMSAIDPIILDQELKREEAIAAAFVAGGGRGGRGGLITSTYGKTKPTVAATTTGYAPAQTTTSATKVQSARKTSLRSPTSRSSSILVGSPVSPATPQRLSIDIASSPPYETLPPTIEDEGPMMRPSQILSELSDIAQHTSDPSRLIRLMQKLAKSVATYPFPPPALAAAPLSQALSSHPTSPAAEADDTTPPHRRRAAPTPTPVQIYLSQSRWLSPHSPPALREAVLALLVASIEASQSATGGMKETDKAIYWDETRRWAEEGKVQADDGLGGRRWMLPDTERELLVTVLSIMTKRGRDLSDVPGLVALLCHFVTESLPTPRPPSPLFDLTLQTPLVRKSASMPPSKHASALALLTALHRFSAPYVYANSTRLALKAMLEVARLQDEDDIGGVQAMDEHGNATWSLSDDSKDGSMLGFLTALIRHGEVAGKRDAHFQAQIDDDFDPEGASLDSDELLHEIVAVVARIIGLEGHVRVVDLIDGDSTPPSTHDRATRPSELPPRAQRLMTELIRSPANQALKSLRSSLIAPPATLPRPLPPVLLLVGTLRSLRKALDDHSKEVETSVERRADSITKTPSWSDHRLPNLLSLGLPYLWNGMRRAMEWQSAPIDAEVLKLMDDRLEAMDRLARKIKDVRKAGAGGIASNLLTPSGMREGGLHQEGPEDEGEQGVGYEEWDMTIDLLMATKWHIDTWETTKLKSWTLEEEDISEDEESRDELAPASSSGHAWRQPEVLEVFAALLRRLIRAWRHEDGFSGPSERVLALLISLASHLPESYALHVLEQTEAHALCLPTRTEWLDRTQEILKAFYVSPSRGQGSVRVLYAGPAASVRRRTLQLVSSLHSQLHHQSEQRDALVSTIILPLLETSFEVETDAEVAEVMITLSNEVVRDSLGTEEVNSGGPLGPFDRLRLLLVRNAKGSVRPFDRYSTSAPTTPKARRTNLASLSRYHKDNSPSAMRSSPSISAPVATPSIAGSTTQEPADISHVAVMGLITMFHVCLETSTYESSEKGVQIFRDLLALLSPAAAPSSDALTDYAIPLRTRMLILAWLVRLRADASHRVQWVHDVDITSAATALYRAEQANGPAMDALNGAMEDGSRGRSGRGSAPPSERSASASRARRGNDDRSPSRMGRRGTQTPATPAGVVIATGPPLWAVPETLPFNFGSLSSSFGAEGLVSFDHHRMRYWTEEQDPGTGQFVAKEIVDPSAASDPEAKVVVLPVSEYLCVVNHLLAHDQEWELLSYLLCHLPEQLSNKHFAAGPRASLQIYTLLKHLCFGLRSIDRPWPNILPMGVKRAEAQAVTYQILTALIAYRSLFSRQQQHEMVETFMCGLSNPRDLAKPCIHALSIASFEMRPSVTKHLSEIVRNLQKIISSAELGVHILEFIAGIGQQPSVYSNFTDVDFQTVFGIALKYIQAHNERLLDAPLTAEDEEGIEYAFSQYVFLLAYYCIAAWFLALRLSERPKFVPFLTRRLVQANEGKPEVDEATEVCFDMIARYTYTNADPRVRASSFDDLLTGETQPALGVGPTLPSKSWIIGTATITISNVKMAGWVEVTIRRASGIVKMMWELQNITGVKSSSDAELVSMYMRHRENAGISGAETIEASAASFQGPTGIAPAAPKLDSAVVEAVNLAHAASLPPTLESGLLTVGPEFFALQLSPFPELAPNTTPVLMPDDPAYGRALRMLDRVPVVDLHKIGVLYIGPGQFTEAEILANTHGSKPYIEFISELGQLWRLKDHPQYCGGLDREQDFDGKWMYVWDDDIAQMFFHVATLMPTDFERHPRSERKKSHIGNDFVKVIFNESGGEFAFDTLPSEFNFVNIVIQPHTPAGNPWLAPGMTSNAQFFKVTMQCRAGMPEIGPLGSFKMVAGTSLPHVVRQLALHSNIFAQIYLATVGFEGGHGKTQRIGYVSNWRQRLQQIKQLKKRINDQRGTAPPSTQGQRLNVEAAELARLFTSWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MAY1</accession>
    <name>A0A2X0MAY1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">6-phosphogluconolactonase</fullName>
            <shortName evidence="6">6PGL</shortName>
            <ecNumber evidence="4 6">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C007g04736</name>
        <name evidence="8" type="ORF">BQ5605_C007G04736</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="4 6"/>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY62794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MAY1"/>
    <dbReference type="STRING" id="796604.A0A2X0MAY1"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000005">
        <property type="entry name" value="6-phosphogluconolactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="6PGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054:SF0">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="7">
        <location>
            <begin position="21"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY62794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="268" mass="29870" checksum="A483166070C6E7E0" modified="2018-09-12" version="1">MPEAQAPSKAAPPPVLYEFKNPDELSKALASFVLAAQDEALKKQNTFKIAISGGSLPKVLGQDLFGRDGVKWDKWEVFFADERLVPLDHEDSNFRANDEELFSKVPIPRENIHVIDTNHLDDPEHVADEYEKQMIKTFVEGSNSIAFPRFDLILLGIGPDGHTCSLFPGHELLEEVDGWVAYLVDSPKPPASRITLTFPVLNHAHRVAFVASGAGKQDILHRALDKPEEGLPCSRVKVKNPGQVYWFSDEAALKEVSYNRTPFESAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MD72</accession>
    <name>A0A2X0MD72_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C009g05537</name>
        <name evidence="10" type="ORF">BQ5605_C009G05537</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY81960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MD72"/>
    <dbReference type="STRING" id="796604.A0A2X0MD72"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="268"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="127"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="445"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="640"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="703"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="735"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="641"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="656"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="350"/>
            <end position="357"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY81960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="921" mass="100421" checksum="0B66FFB77F44576C" modified="2018-09-12" version="1">MQNHFVPFTQHAAGAARPQTPAALDAAPRSPFVPVKKHRSITPPATPSSYHRPSKSMTMGLGSSTTSTSAGMHSPLSPSSQINAVPSFVVQASSPTTMASPPRKVLTHQRSMSALASSALVSSAAHHHSAVASGSSSSHPQFANRAPSPEPMRVRARVTAAATPRRKAVLPGTEHVEAPTPRAPTSHGFNRAMTTPLAPTPVSPNPSVYATPRPLTARTLMKDSDWIGRNHVVAAPIEDVSRGMSGMGLGSARTEPLPRERLSKIQDSVLVCVRVRPPAAKLALSSEVMDEKAWNVDEARAQLSLKIGGPEYNFDSIVTGSENEGVYAEAGKDLVLAAMEGFDAVIFAYGQTASGKTFTLSGNAANPGIIPQAVSEIFAYIRDHPDQEFLLRVSYLEIYNETLKDLLAPETGPLKVRQDEKKRFFVHPLREEVVTGEAQVAALLRRGEKNRHTGQTDFNERSSRSHSVFQMTIESRDQDPYAPSASPLRSKTPNGPRLAPGSNGCVRMSRLSLIDLAGSEQATSQLERRNEGAFINKSLLTLEKVIASLTDGSKIKPHVPYRDSKLTQILQPSLSGDARVAVIATMNPSPMAIEESKSTLRFAQRVKKVTLKAVVNEVMDDKALIHKYRSHIAHLEAQLQAAMSQPSVPSTPSHDNASHSEEEGGGRKYHKSSARVKGLEVQIEELRSLFVNSGNVEERRRSLLPPRPVSPMKVHHSIDGGESSDSEELCLGERLLEAQDEIASLKDLNSSLKARISELEQTHLDHVRTTANDSAKDARIAELVKENQELLVVVKNGDDGEGDLKRLEWKMKREMDKRATYAKALEEALKKEQKRVNQFERFILQHLATQADVISGRRRSSIGLVNHAAGRPSVAGMLPIMNESSPLVVAPQEFLDLDELEFSEEGREQIKNSVSMLFVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MDX7</accession>
    <name>A0A2X0MDX7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C004g02988 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C004g02988</name>
        <name evidence="2" type="ORF">BQ5605_C004G02988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY69288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MDX7"/>
    <dbReference type="STRING" id="796604.A0A2X0MDX7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="342"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="445"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="562"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY69288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="590" mass="60648" checksum="F839223E3593669A" modified="2018-09-12" version="1">MPLPDESSRPSASSLIKRFEAISASQDSSSASAMNRSVSGGAPKRIWSNSSATTAPAASAVAPSLAVDTKPPTSIDTSKPLPEPPTASDEATPDVEPELTFASTQEAGFASSLGAKTSPSPTSQAPVESTTILFSGPSPTTPTRNFPPPIITQSSLDVDAPPVSAVLGSANGLLASSPPNPTSLAELVAGGSKHHSKSSSVDSASSRVSHEGLSRPTSPRVDEQRLSAPPLRGEASPPPCDSEDSPQEEKFTFPAVESKEKEVAAESPAKTGSAPIKGRLKVKSTSSSTSNARAKSTSPPIRRTVSPTVPTVPKSRPSLTSPTASSLAKSRLPTDKPPPLSPKTSPKKTNTTLHKTTTTMASVGAPRSSSSASLISRSGAPSPTPSTASRSSALEGTTRSRSSRATTPSTPSRSPPMTKKATGLGTTTTSTSSTLNTPARNTPRTPSASTSLGSSTPSKFSSRGSNAPISKTLSEGQKVPTRVGNVKMASRGRIGLAGAPAGANPSPRGTKKVEERKDTPKETVEDTQAEKEDEVEAPRDEDIPDIPSDDEERVFDPKTLQGGRPVPGRIGIPMDEETGRAVGDEELKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0ME43</accession>
    <name>A0A2X0ME43_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C135g13394 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C135g13394</name>
        <name evidence="2" type="ORF">BQ5605_C135G13394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000055">
        <property type="protein sequence ID" value="SGY89000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0ME43"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026960">
        <property type="entry name" value="RVT-Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13966">
        <property type="entry name" value="zf-RVT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase zinc-binding" evidence="1">
        <location>
            <begin position="244"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY89000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="404" mass="46690" checksum="7E3B6282FB56D927" modified="2018-09-12" version="1">MMNVFYKKKKKSLERGDLGAPSSRELEVPRRCDPRFQSVGFFSSTARVEKLYRDSTRWGAVVAAARVTVPTIKSELLTLPELLSLPPRLPSLYAEGAKHAYDDADAVAKFAQIADLYWRDEGKGWALVGHRRGFWQHSKEPALQHEHVWSRVGQLLKAKALLPKTALRPARIPLKEAPRPRCFNFFGLTRPFTIRKLRRLVNVVRFPGREDRVKRFRDGTSQSDRKRFWRWLHDRFASAVEQDTHWRLMYDVTPTRKRQHTQGHASSPTCLFCGNDAAVIETVSHYFFECAYSTSFWGGVLRILFDKLGIEDTDVDPSTFTPEQLTMGLPLLRGRGRTTSRWMWVRLACAIGFQRLHLLRWRVHQRFELDKVVAPPSLPSALRAFERDFLSRAGFVPGARDWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MEK9</accession>
    <name>A0A2X0MEK9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C139g13421 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C139g13421</name>
        <name evidence="1" type="ORF">BQ5605_C139G13421</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000051">
        <property type="protein sequence ID" value="SGY88497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MEK9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY88497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="88" mass="9526" checksum="1F5ADEBB49850314" modified="2018-09-12" version="1">MPSPEAAAQNRSTRRRANWFVKSTAPAAGSLNVARQVQRARSSSPPSLRFCANSAVRGPASVSRACRHWASLHDISRSSATFYEPGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MF54</accession>
    <name>A0A2X0MF54_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)</fullName>
            <ecNumber evidence="2">1.2.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C005g03380</name>
        <name evidence="7" type="ORF">BQ5605_C005G03380</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:13458"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="2"/>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY74759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MF54"/>
    <dbReference type="STRING" id="796604.A0A2X0MF54"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007584">
        <property type="term" value="P:response to nutrient"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="6">
        <location>
            <begin position="130"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00051764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY74759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="500" mass="54103" checksum="75309E1580F82EE0" modified="2018-09-12" version="1">MIASTSSRTFTRSLLGCSSCASPRRTLLPPLPHLAISSTRLAIGGPHQSRSSSSSGPAGMPTVATSSLLSTTREAALHTHGLRWRDDESIHPPTKDPDGNIVPGSVPTFVEPSAEDLISVDQGGRETKKMNLYQAVRDAMAITLSKDSSSVVFGEDVNFGGVFRCTMGLADEFGKPLIRALRAPPGSERVFNTPLTEQGIAGFGIGLATMGKTAVAEIQFADYIFPAFDQIVNEAAKYRFRSGDQYNVGSLTFRSREPLSSRDACGDDGADYYFARLGYPSACMAVGHGGLYHSQSPEAYFLQAAGLKVVIPRSPIQAKGLLLSAIRDPNPVIFFEPKILYRSCVEQVPVSDYQLPLSSAEILQEGSDLTIVSYGPPLYTIEGALHLLANPSEDIQSLVPRDLRGLKVELIDLRTIMPYDIETVVNSVNKTGRCIVVHEAGKMGGVGSELAAEIQQRCFLKLEAPVQRVTGWDTPFGMIYEKMYLPDQVRVVSHVSRSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MFI5</accession>
    <name>A0A2X0MFI5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C005g03500 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C005g03500</name>
        <name evidence="8" type="ORF">BQ5605_C005G03500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY76557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MFI5"/>
    <dbReference type="STRING" id="796604.A0A2X0MFI5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18833">
        <property type="entry name" value="GH43_PcXyl-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF17">
        <property type="entry name" value="BETA-XYLOSIDASE C-TERMINAL CONCANAVALIN A-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-xylosidase C-terminal Concanavalin A-like" evidence="7">
        <location>
            <begin position="367"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY76557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="554" mass="61659" checksum="6044B5DAD785FD91" modified="2018-09-12" version="1">MQAYRNPIIPGFNPDPSCICVDDVFYLVTSTFLYFPGIPVYASRDLINWTQIGNVFSRPSQITRLTECEIRYPIGGGLWAPTIRHHEGEFFVTVTLVFPQMKYEDPKRWDNLLFKTNNPRKGWSDPVRFDYPGYDTSLAWDREGVAHVQGSFYWRVRPEISQITINTDTGKALSASQGPKKIWSGEGGKAPEAPHCYWREGWWWIIIAEGGTELGHRCTMARSRSLTAPLSDWESCPSNPVLQSITLPPVGASNSDPSFDSYFMTVGHADLFQSSANGQWFAVALATRDGIEDFPMGRETVLVPVEWEERDEDGSLKWPVFGKVRPKMWAKLPVGDGGQEEKGIEPLKEGGTENLLKLCAKQEEDGQWPVHVLFLRLPDPKAYTLDRSTPSLNLRPNSSSTLLDQGKAGTTTLIARRQTDLEGSMTTKMSFPRGIEGLEAGLTVFLDATYHHALTISGDQKRVIVRSADGVEHGNGLEATDTPGTIDLRVEWTTSEYSFSARIGENSEWTKVGQGKASAVSGGFTGVVVGLFAQGDESKEVVVSEWVYQSTRTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MFR6</accession>
    <name>A0A2X0MFR6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C005g03590 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C005g03590</name>
        <name evidence="1" type="ORF">BQ5605_C005G03590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MFR6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY77267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="106" mass="12010" checksum="DDCD78DB3DB42BC2" modified="2018-09-12" version="1">MILSGARLHPFIPSFPCLWPNRFALAQPQRILHHDSEILDLIQQTDQFSIDRDPAQEPTPSSLALDQRLLLLLLLSTKIFRTTLTEHADDFGTVRAHVSGHVFDQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MG60</accession>
    <name>A0A2X0MG60_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C017g08339 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C017g08339</name>
        <name evidence="1" type="ORF">BQ5605_C017G08339</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY19832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MG60"/>
    <dbReference type="STRING" id="796604.A0A2X0MG60"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY19832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="313" mass="34793" checksum="511C89FE61D29A2A" modified="2018-09-12" version="1">MAVCAHCKARHWECERSKSTGHYSTCCSQGKVQLPPLSGPIPNIEIYLKDSGQSSSIPRKRPVAQQRAVFHFDQTRIGTLGLPVFRVFGRLYHRLGALIPAVNQRPAFAQTRLIDPAEATDTLLGPDSPDSRIQRSTLTKLEFNTEMAILIPTPTREIVDRKIVFPRCTVIDVPMVSPSTKSLARSIRLGCLSGTHYSSPRGKMASTPAFLFAVRSSWATVRQKTATKKVRTRRNGTKRTVMARAQTDIECLNTYDEGQVKGVKVVRLAFTNPLRSTCTNATSPHGTQRPFPAFVIKGYSLAETDQLNYIQLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MH62</accession>
    <name>A0A2X0MH62_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C033g11240 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C033g11240</name>
        <name evidence="2" type="ORF">BQ5605_C033G11240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000066">
        <property type="protein sequence ID" value="SGZ02988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MH62"/>
    <dbReference type="STRING" id="796604.A0A2X0MH62"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="482"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ02988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="762" mass="82840" checksum="327A0C5CA1E4D4D8" modified="2018-09-12" version="1">MASSNETTPIVSSNSRPPMLTRLLATCAPSSWFLPPPHHDGVCHSTATRVQAEAGTTAYDCVARLGGLKWDSPASPGARVLGSFFDILEQHPSLLDLFREKVDAISNAPYSEMPRMSEHEVEMSFLRLLFGGLDSATAALLNHYAAITEAVGASSASASTSATRPRYSVQMREPQRALRTQGDAVVYIQRGAGNVVSSISIEYKRDNVHHSLAKVRQKVALSRIPALDHGAPVPLQKLEEEESKGADAVATKAIIQCVSSKSRFFLLLSVPFFQIGELVQHQSTHAATASDPVASTSAASALISAATAYSPAPPLKARYSLVLQELARWVEPSPTTMNPDAAETLGADLPRRSLIVSFIALAFTAVIEVPKPDQAVIDTLLNPQFQPPNLPRRRSDPDLDPNYEPSPRVQKASKTSIEATGARRSGRLVGQPPRAQTKDSNRPVTPPISVGLQSDPSSDPLTPVTRIFSSPPASTDWSPATSPLSGSGLPSKSITIVQDRGFVIKASLSSAYWSTMSYTGTSRVELVEIGFDIVSSVPSDSPLASRLPSKPSPASDFIRGLHLSDVVLRWLSENPREELKDDRIPLELLDRFEPTADLRLEKEVGSGSTAGGWLAKVVQVNRPLCSSAKAEAPLVDHPAPNTTYFLKLVTCRYVGSVIRETLFYQHVLPHLPEHLRKHIPQYHGTYRRTNGNGYAMVLENVGKTMNELDFYGSPGELWEIEAAFRELGIIHNDVRAGNVLVRPNNGPLCFVDWGRSYLKLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHP1</accession>
    <name>A0A2X0MHP1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C011g06327 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C011g06327</name>
        <name evidence="1" type="ORF">BQ5605_C011G06327</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY11935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHP1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY11935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="51" mass="5619" checksum="7608C15C5068A5D1" modified="2018-09-12" version="1">MSPFLDLTLPPFGPAARSPEPTGSRLSLLLKQLLGLVSLVCRSEPYHRLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHW2</accession>
    <name>A0A2X0MHW2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">BQ5605_C019g08919 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C019g08919</name>
        <name evidence="14" type="ORF">BQ5605_C019G08919</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY23244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHW2"/>
    <dbReference type="STRING" id="796604.A0A2X0MHW2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000023">
        <property type="term" value="P:maltose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000254">
        <property type="entry name" value="MAL31p Maltose permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF5">
        <property type="entry name" value="ALPHA-GLUCOSIDES PERMEASE MPH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="69"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
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            <end position="172"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="242"/>
            <end position="265"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="369"/>
            <end position="390"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
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            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
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            <begin position="425"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="512"/>
            <end position="537"/>
        </location>
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            <begin position="76"/>
            <end position="543"/>
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        <location>
            <begin position="1"/>
            <end position="23"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00049119"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SGY23244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="588" mass="65161" checksum="D53C5F5E6BCB33A4" modified="2018-09-12" version="1">MPISSTTDREFDKSVGTGMVSPNQVHKTIIPEPQMLERVSTQLGDTTVNDAAETANKERHMTMWQAFKAYPYACGWSMLFSSAIVMEGFDLAMINAFFALPAFQRKFGVQLADGSYVITPAWQTGLSNAVQVGSIFGLMVNGWACDRFGYKKTIAVSLVAITLFIFITFFAVSLPMLLIGEILCGVPWGVFQSLTTAYAAEVCPAPLRPYLTTYVNLCWVMGQFISSGVLKGVSGMSEDNEWGYRIPFALQWMWPVPILAGAVFAPESPWWLVRQGCLGDAANSLNRFGSISAEGFIDVDAKINQMIFTNEIEKEINAGTTYFDCFKGTNLRRTEIVCMVWMIQTLVGSGFISYSTVFFERAGLSNSNAFSLSLGNYALGAVGTISSWWTMQWLGRRDLYMWGILSMGVVLFAVGGAGFGSGSGASWAAGALIVFYSFLYQFTVGPVCYCLVAEISSTRLRAKSVVLARTSYNIVGIINNIIFPRMLSPLSWNWNAKWCHACHLRYSLMSSLLTIISCQAGFFWGGSCFLCLIWCYFRLPEPKGRTYLELDILFNDKVSARKFKTTAVDVRAHGRSNEKHHEPTGIVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MI35</accession>
    <name>A0A2X0MI35_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C039g11827 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C039g11827</name>
        <name evidence="2" type="ORF">BQ5605_C039G11827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000060">
        <property type="protein sequence ID" value="SGY90767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MI35"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY90767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="295" mass="32351" checksum="8423082C332413C7" modified="2018-09-12" version="1">MTDLTAQKWPAANSRWNSIEDLSLLFHLSLLEANLSPSFTSTTRPAENGQLPSITIMANIPGCKHVVLAQVGQPSPQEWVVNRVPLFRTAAIARLQEKSRAIRRGRKGSRSKSKANPKKVLAHGHREEPADLETYLNRGYIDVGSELLGPTDLTRLEGSLRSCARRFSLKCLPHRRLGSNGGVLVFAQRTRAELFQCSSSQPVIKIGTPPQVLRGPASQAAAPAPNRYRHSSLIKDEEDDDEPDPVEEEELVAESAAHRASTPDRQVEIFSTADGGSTTVSAKGDFLGVWVPKHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJJ8</accession>
    <name>A0A2X0MJJ8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="26">BQ5605_C029g10726 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">BQ5605_C029g10726</name>
        <name evidence="26" type="ORF">BQ5605_C029G10726</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ16070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0229">DNA integration</keyword>
    <keyword evidence="20" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="18" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="21" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="17" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="18" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="19" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="25">
        <location>
            <begin position="534"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="791"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="845"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="905"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1462"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="791"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="847"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="SGZ16070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1651" mass="180039" checksum="62136C11CF32CE64" modified="2018-09-12" version="1">MDSSDPTTPSFPRDPSPLASSITDQLATLQAQLAALQASQPPAATASAAAASQPTAAAAAATTASKVVFPKHARLDGSKSFTNWLRQLRLTLPNQIRGYVLDGVVPPTWTADQLAARDDAAREIIVGSIDSADVSATLDAIPSDDLSAPRIFAALKARFAPNDATRTLELFARLWDFRKMPASVEAYDTWLREYMAIAQEICDAKTSLNDVLATHILAMVPSCLDSFRLTFTDEQRAQRKLPELTTLTDRIRVQLRSAGLSASHSAMLADAPSCPACRAPGHRLRDCTSRAKHPPTGPCRRCQKRGHWALDCKNRGQQTRTSDDTQDDLSSSTAHRPNVGYFASCLFARRQLPTDAFVVDSGATTHMVADRSLFTTYRPTAHTKIGGIAGGITAIGMGDVPFVANTGHPITLRGVLHAPGLHVNLLSVSRLCDTDRDGQAIAHGTRVNDGLYLLDADHTECQQLAFLSCSESTVPLLTLHRCLGHLAPSSIQKMIAAGLLDGFGAGYSDKDIEEFVCNACLGSKGHRLPVPDSESHSPERLGLVHSDVLSFPTPSLTGKRYLVTFLDDHSRKLWAYAIDHKSDVFPTFQTWLAKVELETNARLRILRTDNGGEYQSNAFTEFCQSRGIRRQYSIPYTPQQNGHAERVNLSIVEGVLALLADSHLPATFWDEAAAYFVYCKNRCSHSALAKQTPQFVWNGQRTTATALHPFGCAAWLTVAPDLRSKLDPKAARVIFTGYDLASKAFRFFDHSTNKVVLGRNATFLDDDFPGLPVNMPVDADDAKRQFVIPADAPAPDTADTHAPAATPAPAVKTRTPLVRSAHMDVSSPLDDSAMSTVDVAPGYTGGSLLNSTDTSPSSSPSLAPISSPATSSAGGPSIEDSDDPLDLLHSDTAVRLRLMDVHRSDNDTLVTPTPAVGPGQPSDDDSPDEIDFLSRHHRAFIATDDDNPTLEAIELVKSITSDPQTWREAMSSDEHDLWAQAASDEFTAMRDDFKVFTIEPRSSVPPGATIVTSKFVWKTKRNAQGDITGRKARLVAQGNRQRDGIDFSETFAPADIDKAYLHGELDHDIWMTTPRGFDFPSDQVLRLRRSIYGLKQAGRIWNRHIDTSLRSLGYTATGTDHCIYSRIDDQKQPHYIALYVNDLLIVSPALDKIECVISGLKQRYGVKQLGPAEYILGIQIRRLEDGSIALSQERYIMDVLARFHFDTTTRGATVPMTPGLSLTAVPGQGTERIRSWYLQAIGSLLYISLGTHPDIAFAVSYLSRFTNNPGRRHWVAVKHVLRYLRATYRDELLYACGPAKITGVVGYSDANWGACVDTSISTMGFVFYLAGSAVSWSSKRQTRVADSTTDAEYLALSHAGKEAIYLTQLLSELHVRPVEAAHIFTDNEAAAAVAHDPVHTSGTRHIRLREHFVREMVHQGDISLSHVGTANMVADIFTKALGPKIFGVHCYALGLRTRHPRLKSTSRSRGGGCEESTLRSAQDLGARSESGASAQDLGVCCPCRRCHKKGHWALDCKHRGKQKHTGDNNQDDMSLPAAQQPNIGYFASCLFARRHLPADAFVVNSGATAHMVADPFVAKTGHPITLRGVLHTPGLHVNLLSVSRLCNTNRVRLAFTSDGIDIAKDGQAIAHGTRVNDGLYLLDADHTRCQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJM5</accession>
    <name>A0A2X0MJM5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C010g06054 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C010g06054</name>
        <name evidence="4" type="ORF">BQ5605_C010G06054</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ANP1/MMN9/VAN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJM5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052086">
        <property type="entry name" value="Mannan_Polymerase_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083:SF6">
        <property type="entry name" value="MANNAN POLYMERASE COMPLEXES SUBUNIT MNN9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083">
        <property type="entry name" value="MANNAN POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03452">
        <property type="entry name" value="Anp1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY14082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="521" mass="57188" checksum="3DAC68D6B4779B9D" modified="2018-09-12" version="1">MDSKTDGGEWDHLLENGAVASDLPSRDQIAWTQQERAQGASAARVGAPSPAQTSSLGLTRLCKQIGGPQLTRTLAWGTLLVLAAVGFMTLVGFAHGSLNYVDYSWRDIHQAGWSRIPARIDLGAETSIPIQYSAADSAATAQTDSDLSSSNWRADHDPIRQQQQHSDTLWNTHDLSKSSSEPDAPLTPPSTSQAATAASDLHLLILTPLSTSSSDLNHYFALLDKMVHPRCNTSLGFLVADEQDDTASRLQQMLLDRPGFREITLIRKDFGIEGPTRGARHRRWWQQQRRAIMAKARTVLLMSALNASIDWVLWLDSDVAEYSPSLFEDLLLYGGTGVVFPNDSQHRDLPPLPSEGDIPADIVVPNIFIGKHSTLAPYDLNSWAETTRSRQLKANLNPSKFIFEGGGTNLQRAHLTDAFVRPSKPVSTYTASLYPHYRPEGWEESDLYDRNSPAFVGRRMDLDGVGGVATLVRADAHRMGAVFPAFLVDHQLETEGFGVLAKALGARIVGLPNYIVLHSNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLD8</accession>
    <name>A0A2X0MLD8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C002g01675 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C002g01675</name>
        <name evidence="3" type="ORF">BQ5605_C002G01675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY34743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MLD8"/>
    <dbReference type="STRING" id="796604.A0A2X0MLD8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY34743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="254" mass="27993" checksum="6046B1757AD6C4C9" modified="2018-09-12" version="1">MHHTAIDKPRIAHIWYTYDTTLAETNPHSYTRLDLDAILTGASSVGKSSLLLRFTDETFLSPDETSATIGVDFKVKVIERKNKRWKLSIWDTAGQERFRTLTSSYYRGAQGVILVYDITARDTFESLTSWIAELDTFAGTGSGAKEVVRMIVGNKTDREFSRVVSTAEGEAFAQAQNPPWLFMECSAKKGGEDVTGEDGLFSRVVDKIVETPSLYMKNNIGVNSINKKGPPGQFPSGTVNLDEAEESGGGWCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLK0</accession>
    <name>A0A2X0MLK0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01735 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01735</name>
        <name evidence="2" type="ORF">BQ5605_C002G01735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY35172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MLK0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY35172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="126" mass="13872" checksum="CB08443926A80BFB" modified="2018-09-12" version="1">MTHKPPLGAAHITNMDLAPLPAPLHLRPLRIRSVPTPFAIVEVQRFLADETANRVLSGAGASAIKEALVRLVKRLEQEQSEESASSATKVDTSSISEKEKDEGKKRKVIESELTKDKKQSKKHKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MMA0</accession>
    <name>A0A2X0MMA0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C028g10589 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C028g10589</name>
        <name evidence="2" type="ORF">BQ5605_C028G10589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000080">
        <property type="protein sequence ID" value="SGZ13736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MMA0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ13736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="737" mass="82977" checksum="7853555DE4C85EBA" modified="2018-09-12" version="1">MGIFLRLIDEIRGRGAEFPTAALLSLDQSSAYDMVEHDWVFAVFEALGAPEPFQRVLRMLYNGETSTARYIVNGFLTETVRLLCGLGQGDPLSSSVWDVVFQPFLDSLSRRNIALTITLPELAHRPQTRCITNLAFADDAVVAVAGPEAIASLEALARDWRLATNGRLNTDKTVVMPLGATLWDRADLSKLSFVAPDESLPWIGLQFAPDGNNRLGFHDLERRVDRVILSVRDRWMTHHTRAFYLNRYGISKVLHSLSADIPPSDVIKSIERKLADFVKGGPRRSDYKQSVVFTARARGGLSVVSIQDVVDSVSVRIWDVLAGGSTAIWGDLARSSIRRALPTFDFAADLWTWRNADAPRELHPRWRAVLSVAERYPAVVDPAKLSVSNLLSLSPLQPGLHDSRAFSEQDKRLAKHFSFERTIADIYARAQYPAAPTVPWTPEKHPQGDGSELSNLWQWKRDQVQAWIQVAGDRFIPPLPPPVPVLARRPPVIRVVGAPGARAGGPLEHILPRATPVGMPDQRLPLPSAPLLANQWRMLSLDRPYTIARLRRVINHRRFDDTQRPGSLATPKERRLFWGWFHTGPATAREREVHFKLAYHFTPTRKRQFVQRHGDSACCLVQACSLAGVEDDFTHFWHDCPDSSQFWQAARSIICDALGVVSILDLDYTALQIEHGLPRLRARLPTSKKRPIRAFIALALDTLSNRRWDLHRHARAMSSMDKEMAGLKERLELRLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MME0</accession>
    <name>A0A2X0MME0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C020g09158 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C020g09158</name>
        <name evidence="1" type="ORF">BQ5605_C020G09158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000082">
        <property type="protein sequence ID" value="SGZ18017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MME0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ18017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="148" mass="16305" checksum="4A16EB79464A4FCE" modified="2018-09-12" version="1">MPVPIRFSRDYVSMSTLDSSPNPQLISMNPAQKLPVGSRYESVPHVGPGTAVYVRQPTRSQLVSLLSCWCPWKRGSLYSGAAPREQKANSGLFSNPNRAFYIPDPEGKPFVDVDGVESGPRWILIDPQGKVGSDDGKKHKEERGCCIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MML2</accession>
    <name>A0A2X0MML2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C029g10680 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C029g10680</name>
        <name evidence="2" type="ORF">BQ5605_C029G10680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ15553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MML2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ15553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="171" mass="18784" checksum="4970C57C85946285" modified="2018-09-12" version="1">MPLADATAILEFSRQPSKPPTLLAHEAQSFQPPLPTPGWFASRSPPQSATNEAEYGVPTSPKGPYSPQGDHESERATSTFLVGKIRSLNLSRLEAVDAIERTPVAKPAQRRQKRKAAFVVSAQRHQNLFFTRGQGTLGAIEIIDLRCILGSAGRIYRRVGRDSRGASRVYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MMT8</accession>
    <name>A0A2X0MMT8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C026g10187 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C026g10187</name>
        <name evidence="5" type="ORF">BQ5605_C026G10187</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ27777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MMT8"/>
    <dbReference type="STRING" id="796604.A0A2X0MMT8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46225">
        <property type="entry name" value="C3H4 TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46225:SF19">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="482"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="386"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="535"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="37"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="386"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="409"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="540"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGZ27777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="564" mass="60466" checksum="302FB36D68355CC3" modified="2018-09-12" version="1">MSPADAQDADLTQASTTPCVAMKASESAHESAFDLRSSPASPASPASPTSPAEHSAPSSASAPTSSSSAPPAEVVPLTIDHIDSPFLIEAGSTMPHDEPPPNPVSPDDQVDLVAILDRIKRRRQAEAEAEAELHRDTTTYPPNASTENDNINVEIPGQAGSGMVTDALQIRLSLAGRVIASLAQGKAGRDRLIVTTVIGVAQIIAWSVVLAKTTHSTCVKPLRVYLILIIIKLAVQFPFAFYRAVTPPVRMSSDSEQVIAQREATRLVGSPALDRRVKRVKDLVWLYSLVLFVIGNVWVFGASQCRPTAPMLWKASVAALIISYLSMFEAFAVILVVMLYLPFALYNLGSYMAPAQNEIGPISKKEIAKLPKRIFIGTKSEATTAGPSEAAAACEGEATTSGPTPLSPPIQTNLPPNTKVDSSVPPSPAPSKQGRPRRLHLLWRSARKRTLPQGLSTSDATSSDFVDLPVPGILVEPSQSACSICLGEYELPPARGESIADWEPELLHLLPCGHCFHVYCTETWLATSGRCPVCSTPVSEEGRRKREESQRRAQEDQLGRAAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MN65</accession>
    <name>A0A2X0MN65_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C020g09196 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C020g09196</name>
        <name evidence="2" type="ORF">BQ5605_C020G09196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000082">
        <property type="protein sequence ID" value="SGZ18673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MN65"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ18673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="131" mass="14484" checksum="228EBB8E4648C557" modified="2018-09-12" version="1">MGGGERARELERKRLKELMCERLGLELGGEGEKEGEKENGLNELPSLERKELGKEKDEKDEEVKSLRKQVMRLNEENKRLNARVKGLQEEVVAAKASASARQGTMGTTSTASALEGVGAIQLKELEKSFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNA1</accession>
    <name>A0A2X0MNA1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C027g10338 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C027g10338</name>
        <name evidence="8" type="ORF">BQ5605_C027G10338</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MNA1"/>
    <dbReference type="STRING" id="796604.A0A2X0MNA1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="57"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="746"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="59"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="746"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="776"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGZ28445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="881" mass="97096" checksum="43086A859228348C" modified="2018-09-12" version="1">MESLAGKQLRTSRSRAACAGCRATKQKCDGPSRIPCRRCELYGLACEYPPVQLPPKPSANPRAAGSAAPAVASTSSSLPPTSQLSHQPSFVAAGSSESVLNETLREIVDRLRSLEASVTNLHLNSNTFESTSQSEKSADPLLIAAEPYPEASEPTPSDSPDSGDGQQIAPSSTLPCHALQNISATIDFIEALETSQMAPALQDLDGFAEAARSTFPTLESMLPDTMRPDAIDRGILSIAEVEANFLIFFRMLAPWILVFDLSKDSNAMEVRERCPLLFHTILTSTGYYLMGTSERGTKVYKALVALTNELIAPIIISTQVYDLNSDLLRALCLLMMYKPVQLPAFHFSGRVHTAERAEQYAKLNTTSSFVLWGIIARVSTRIGLPSVPSLFAKLYSPDVPVPASVVADLRLWMWIIVIDNHATLTIGRPTTLDMTDVLRATRLLASLKLQTGDVRLAALVELYAVSRHSVSKAWFTDFTKRAPAYELRKFNRDLDEWEQYWSEPLEAAAKEGDALAMHPIYVISQLIRAIINSTVFMRWQRERRVSLAKGLNERPEMSSDDWNSLQITLDAVERQIFALSAESRVEGSQRREVHWASRPFDIPKGGRPFLTLDQKVVDVYRTAFDPIICVAFVYPLLLVSRMCNAALVNCELKVKDQNAYDSGSLTLNKPQFMIKGAKVARLLDLSSRFLDAVAPTPSHPAKRHARILRAMFVLGSVDLSQLPNTPRRDSVVEPVLDEATTIVDLSHSNSHSPALSSSSQPPPSYHGHQQKDPTDSKSSPRTRYPSAQTSFDLLGPSTDQPIEAGEMLHSILSGIDLTFFGQEMAYGLEPARSNADPVGDGGSMMVDWANLDNTINSVEPLPQFLPSQMDYFEMLARQGQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNF9</accession>
    <name>A0A2X0MNF9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C022g09520 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C022g09520</name>
        <name evidence="2" type="ORF">BQ5605_C022G09520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MNF9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ22665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="629" mass="68967" checksum="8BCB929D1AB31755" modified="2018-09-12" version="1">MLEPRTFNFSTFSDLRYSVFPPYCTIWCPASSTSLPAELPPQPSYVMRRSPGETLPEHPLAFAVCDPTIIDRALSTLESGLAREGVTQDSALPSDATIVAHQFRDHILDPQQSRRGYWFRLNRILTFMVMPILHELLGDSEGLESSLLTDCIGQPAEEAWTVGVGKYNREGEWPVLESFVDLIVESTTVEALRPLHERKRIANTGEGARSPTGPDDWEPIDMRIVDAEGQDQALEGVSAMVAQMSLHILSAGVGRFGLFYATPYFVLAKLVVIDGQTFLLYGALDSFVLEPDDPVATSRPFLTVLVALLLSCHPSFAIPGPSEAVTQRLRDHARGRDHPHPRTLDGCGPLQNEADPVDRPASEHSEMDPGNASLPFLNGSVTSVSLRHIPKGSIICDAEGFAESRMLASPVELDCSDIKLYLSGDYWPGQAVPVPWNRIAPVPLELRLDLVQRIGHGRTSTVWSARWTPIGAAAAHVTSPRSGATNAPDAPGAQLVAKVVLDKYATSIAREYFVYTHIVPSLPPATQAFFPKFHGLYRSGPAGTAYIFVFDHAGEQLRTIEWEADAELKKRDLVASAGLYHGDERAANILRRPDGSLALIDWGEATLPLPNRWRPRRLRTVKATAPGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPB4</accession>
    <name>A0A2X0MPB4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C017g08371 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">BQ5605_C017g08376 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C017g08371</name>
        <name evidence="2" type="synonym">BQ5605_C017g08376</name>
        <name evidence="1" type="ORF">BQ5605_C017G08371</name>
        <name evidence="2" type="ORF">BQ5605_C017G08376</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY19894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY19906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MPB4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY19894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY19906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="60" mass="6985" checksum="3CDDF4D52B589C9C" modified="2018-09-12" version="1">MCSNGYKRNKTVLKNGDSRLVGSSDWPRRTRDLNRPVPYSKCWNSNTVRCSQSFCGSHFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPJ1</accession>
    <name>A0A2X0MPJ1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C022g09489 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C022g09489</name>
        <name evidence="9" type="ORF">BQ5605_C022G09489</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS54 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MPJ1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039745">
        <property type="entry name" value="Vps54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012501">
        <property type="entry name" value="Vps54_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07928">
        <property type="entry name" value="Vps54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 C-terminal" evidence="8">
        <location>
            <begin position="886"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="200"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="381"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="665"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1136"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1378"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1488"/>
            <end position="1550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="396"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1138"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1196"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1220"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1246"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1271"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1289"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1379"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1394"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1536"/>
            <end position="1550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGZ22449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1550" mass="166451" checksum="7FCA95E32F58C3F5" modified="2018-09-12" version="1">MTTIPPPPPIGSNETGQYHISSIINDRNGITAASLGSSISSGTRLPALSLAQNPYLPSSISSLGTTFTSAGTLPKASATSKSVAQRRSQAPPIVIGGGELRQVHIDEFAAYLKEVAPAFERWQRESRLGRDGTADVSNSPVLTRDDGTFGVTIDHKHAVVINTPRLGREEPLPPLEQVPQIFFDPAFNLSNPRTFDLVTERIKSSPPSSPTRTSDLDDGPGSAPGRTFTSTGLATEPNDGLGPLTFADLVTDQVLQEKLSHYTAVIESHLVREIGRRSSSFFSALSNLQSLHHQGDMTLAKIAELQTALAPDRSGVGGAAKRGLSILRAQARRRGLEAIERGVRDVEEMWNGVEAVKELVENGEWIGALEVSEQIEAEYYGTHNGGGVEQNGRSKSSTTANNDNTSATPSTPNAKRKHSNSNEASTRLRYTRVKALDGLPRKLRLLRTQVAKSLETELVTVLNHEMDVGIVDYQRLVAVGRWIRANPSSTTTTASAPMSGSSVTPLSPAFTSAFGVSLSDATDETSEVGQEQTRERARDRIQPIVTALVRADGMDGAVAAWRENVLKDVRRLVREHLPFSDATDSPMGEPDDPLALASVRVSGKLGTSELSDKSATLAKRLRALSHEDFMRLARATYLGMLGALEIVDVHAHVLNEVARASYDDERASRARRTSLDGDAAPNPPRTSSLTVPGAELESISAKGISAGSHDQSSVSDEAALYSDITDVVHAVAELANLRFSKVIGVRTEQHAHLPLESFVEIFDTSWAFVLQCETICQRMIAGLRGVMAGQAKTFLQTFHQRRLTDSAKYVEEEQWAAADVPASTQHIVNLVIETATNDPPELLLGQRVVEAKLESKDGTPSSTLIADATPEASVAKSAKQVDIEGRKYFAVSAGVLALDVLADYLKVVINCPLLTTDAMSKVVEFLKSYNSRTCQVVLGAGAMRSAGLKNITAKHLALASQALSIMISLVPYIRECLRRHLNPKQAIMLVEFDKVKRDYQEHQSEIHSKLVAIMGDRLEVHAKTLKSLNWATEDTSNQGANAYMESLVKEHITLHKVLSRFLHTETVVFIMRQVFTALEQRLKLEFAAIELANEGGKRRMLGDVAHLRMRFSELRGLEDLVPGKELETLVAAKDVPKPVAPKPKPAPAPASAPAPALAPPPIPVVEEPVISAPPAPPTRSSTESAEPTVAEPIPDTPATTPTSEAPTTTAPSTPIPAPSDNVTLTPTFTSPRESLDSNRPPFDSPPMTSSRTNSPILNRAPPTDVPLSTDPPKRKSVAERLAEMARRGSNSAASKASSLLHPSVKSSPKLGPGLAQVPEALEKDGTIEDVVAAAQPREVVGVANEVVRTAAPDAESTVIVDKLDTAEIKIVPIVEGIPEEAKAEQVDPKEEAQEPAADEAPAPETIVDPISSTMASTPPPPPAVDEVVTPMQFESEEARVEPQLPTGEVVDSVTPPEISDFIPDHAPEVVADPTVNIDEAIADLAQEASFPVPEPITKTELESVPNTDDDETPSDVADTSPSSVTPAPEPTKSEIDEIEDVEDVEEACFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPS9</accession>
    <name>A0A2X0MPS9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C046g12257 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C046g12257</name>
        <name evidence="3" type="ORF">BQ5605_C046G12257</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000112">
        <property type="protein sequence ID" value="SGZ30888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MPS9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="553"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="453"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ30888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1195" mass="128883" checksum="71045A8002495D91" modified="2018-09-12" version="1">MPDPPGPPPHPPNAPWAGDVLRDESLNTETRETVTGGTVNPPAWSAQASQARLDHEKSMQKAFKALGIVPSSKSTRRLMVLLYDPSSPPSQAPALARAAQRAVRNDAMPASNVIRVIMDGTGSPRGPVQIALRKHFGLAETPFMFARPEGAELDPEVEKLFSKCVKLNPIVTKATKRFPIARHMYELVFESDQACLEAAAAGPFPYHGKEMVTKLPSVSPLNHIVQVRFTLPSSSSAIPASVLRKSLDAALTSSFGHAGCTQGYTLMQLQRGLAVDPNGDPMAMTEDGFHCAYLRLHADLFQGSTETQKAALNATLPQEIEILGAKYGLQHEFETHYCAVCDRAGHRWGACRKPISTPATAAPVPGASTSTSTTGFRVAGKNGKHGGPAALNSRASGTNMIQLGPRANPAGSATGNKDDANDGDGDDDDDDGESVASTEPEGGDTGKETLTRATTGPTKETQTTTAAPVSTPTSPSPSTSAPASPLSGGTSESSATSTTSIASTSPRRLRSSSAPGNRRVTRAGSAMIHGASGGDDSGGNSSGGYRSESLTVLTFNVRSIKNAVNQVKIIRYLKTLRPAPAAILLQEHHLSYNALRERFESAWPGACIRFAPHVLTLIPDGSPLAGRLLSSTPVVFAEAPQFDGRILRSVFRLEELDIEIINMYAPVKGEERRDFYGLLHFTAPGPKTLRILAGDLNDCPDVSVDRVAITDRAWTPVSHWQTLLSKIAFNPLDTIRQLHPITPAFTRPHYLGRGDKREICSWSRIDYILVQRSWANRLLSASTLFDAPCSDHRPVVATFALPTSNAADAEPPPALPTTSEFISRLNPTVFNDQDFVDSIPGVVDEVYRRLEGTAPLGDVYDAALRAVAAAGHARYRSTRADMRRLRAENQSVMEALEARGEHMNEAERDAYALAKSQLDQLAVKEAQWLRIRAHVPSVDSREGQSASIRTRLNRRSRQTSIVSLEDVDGTETVYMQEALGIASRHAQSLFTPDPARGDPTNARRSLLDPIRAAKCYDDDRSDPTFGRRLPLQARVALDEPFNLSEVKAALKKTDSGRSPGPSGIPYELFKALPTYFAPKLLDLFNSIWEGGKMTASLAEGLVRLLPKNKPGANLKSLGAYRPITLRETTYKVLSKVLVARLNGVLGELLPPAQHGFMPSRRSADAGSHLTLLLEKLRSLGTDVFPEGALLSLVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQ55</accession>
    <name>A0A2X0MQ55_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C025g10055 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C025g10055</name>
        <name evidence="1" type="ORF">BQ5605_C025G10055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000087">
        <property type="protein sequence ID" value="SGZ27103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQ55"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ27103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="70" mass="7362" checksum="92684BCA8036E7EB" modified="2018-09-12" version="1">MLKNSLKTVGSSWALGQTESTADHRLEKLVGTGSTAGGWLAKVDRINRPLVADKTISVVDGPFSNASCFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQD2</accession>
    <name>A0A2X0MQD2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C016g08199 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C016g08199</name>
        <name evidence="3" type="ORF">BQ5605_C016G08199</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY21123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQD2"/>
    <dbReference type="STRING" id="796604.A0A2X0MQD2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037470">
        <property type="entry name" value="IVY1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38407">
        <property type="entry name" value="PROTEIN IVY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38407:SF1">
        <property type="entry name" value="PROTEIN IVY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="290"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="359"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="477"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY21123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="546" mass="58847" checksum="F1C773D3F7B66A6B" modified="2018-09-12" version="1">MAPSIRSFRSATQQATHQSNRRGDASPTLTATTSASFLDLGAEGPALIINRADLRASVAAYENLLAAAKAYRNAMLALSAASTGFAHALEECARVKGAGTSGEQLLAASGMQYLVASSGQILSDTLYRSFEIPLLHAYDTYVATVSARHSEYEALLAEKTAAIRQTEMENMKQGRKKNRDLAQFRKALERLQEQVMQVEVCKRSYYGEVLEHETETWHSISGKIALVLRSTVDLSDRLATKGTSDPVLEAMMNEHPDPFNVYKAHDEPPRDIFTVLPPLGMNLGLGGSKRSSISIDDEDDNRTQNDLPRPGSSRATSREDSTTTPKAGSWKTTTSTSVSVADALGLDETPTKASPRGGGRGEDSSEGPREKNLTPRRGAFRRNKSSRSRDSSDGASPKPLSSLRPVSNGRVNNEEEDEEEEEDHDSSPHDSSPLTGTSNDISSAHHHQRTSSQSSSSTGGDPNKFKHTTHTPLTSPRKARHSNHQGGRRHGELSCVTEADAPPDPMSGDWGAPIYGKSLSPVMNGTGGGYDSGEEETVWGGQRSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQD7</accession>
    <name>A0A2X0MQD7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C001g00322 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C001g00322</name>
        <name evidence="25" type="ORF">BQ5605_C001G00322</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY45693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="591"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="831"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="878"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="936"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="840"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGY45693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1479" mass="161978" checksum="C55E2EBED009C709" modified="2018-09-12" version="1">MYDVTPTRKKQHVQGNASSPSCLFCGNDAAVIETVSHYFFGCAYSASYWSGVLRILFDKLSIEDTDVDPSTFTQEQLTMGLPFLRGRGRTTSKWMWVRLACAIGFQRLHLLRWHVHQRSEKDRVVAPPSIPSALRAFNRDFLSRAGFVPGARDWEVCYEPNVAAQPTRVIKSSCPVIRTLWYQGEQPLSSMSNPAISTRHATCATREAGRNGSTTSKPNARTDLEHANFQAIALLRRSVSLNIKKQIKDGFDHTPTDVLKMIKKAVAAGTVTDIFIKLQALLDAGPPPAGVDAFEKYQANTIELFNTLSGYNLTFDQEYYTQALRQDLDKLPDPIEALQTLQTQAESTPAHKPVAMVASLTATDRSSSTPSAPCRHCGGPHWNRKCPVKDKKSKASSAPSASLAAAPDISTLVDGPVRGYLTAAMSTLAKPSLILDSGATHHIVNDRACFTNFRKCKPAPLEGITGEAVNSIEGVGSAVVRSFDGSIGQLHHALFVPSAPVSLFSASRANAAGYDINLSRGKATVSVDGSICHTGEITNGLYHMHASLVDVTTLIEQPVNMEVALNADLKCDTCQAGKITHHPFPTVASNRSAQPLDRVHMDLLAFDGAVSLGGAKYALVIVDDYTRYLWAIPMSHKSDTFAAFKSWLAKVERSSSRKLLAVRSDNGGEFLSNEFSSFLEEQGITRQLSIPDTPQQNGVAKRANRSITEGVRSMLHQSGLSHALWAEALATYVYVKNRSPHSANSGVTPHTRWHGSKPSAGHLRVFGCRAWKAATTEARSKLDPRGIPLVFVGYDLESKGYRLFDPATRQVFKSRSVTFFEDEFPARREGITAAHAPVAGDDDDDDDDDDDEVVVLPDQHANQAPPDQAELPAALRFDAPGPAWQPPVGSRPRNPPARYGALASLRSTPSAFAFSLGKEVTELVADLEAAGIDTSTANRPLSEPEDPFSLPSSDPTTWNEAMRHPHAAAWKAGAIEEFRSMKDDLKVFSVVELSSVPKGATILPSRHVFRTKRDKAGKMVSLKNRIVAQGCAQGPNSFNNTFSPTAKYTSIRTLIAHSASKGHHIIQADVDKAYLHGVLEEEIYMRVPTGIEGYEGKCLRLHRSIYGLKQAGRVWNDTINATLASLGYRRLACDECIYRHEDAGGDHYIALYVDDLLFFGPDLGEIDRVLDQLDTLYGVKRLGPAEWVLGVQVVRHDDGGISLLQRQYLLDVLARFNMSDCNPCKSPMEANLQLSPEPDTDSADNAIYRSMIGSLMYAVVATRPDLAHSVGYLSRFVGKAGDTHLEAAKRVLRYIKGSLDLGIHYTRTSAPLLGYEGYSDSDWGSDIQTSRSTMGYLFKLAGGAISWSSRLQPRVACSSTEAEYLGLSHAAKEAVFLRSLLTELGLDTSSPLRLLGDNQGAIALTQNPVFHARTKHLRMLEHFVREHVRNGEISVTYIPTHDMVADIFTKPLPRVVFQRHCDAIGLRRISGQEQGGVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQL9</accession>
    <name>A0A2X0MQL9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C026g10226 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C026g10226</name>
        <name evidence="1" type="ORF">BQ5605_C026G10226</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ27950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQL9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ27950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="134" mass="15331" checksum="A0ECFE4739B4734E" modified="2018-09-12" version="1">MQNPSTQFEGVQAHRPKLFNSNWSSLKSWKEQRAVEENLIGLIPRMTNWVFSSRLALHQISPLFNFKRVLDLILRLAREDGAESRSQINDWIADLEQADSISIKEMKQLTPKINTLAAALPQRHIDPGSQIGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQN3</accession>
    <name>A0A2X0MQN3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">BQ5605_C001g00412 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BQ5605_C001g00412</name>
        <name evidence="16" type="ORF">BQ5605_C001G00412</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the neutral sphingomyelinase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY46314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQN3"/>
    <dbReference type="STRING" id="796604.A0A2X0MQN3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF24">
        <property type="entry name" value="PHOSPHODIESTERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="15">
        <location>
            <begin position="11"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SGY46314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="470" mass="51203" checksum="463B0C2BE6273F71" modified="2018-09-12" version="1">MSAQPRPLRVLSLNCWGLKFVADKRRERLLAIADWIATHSNPLSLSSSRNDDDDEERAFAASTSPGDSLAFQSSSQGGHYDVIALQEIWVRADFDVATRFPFSGAIGSGLAILSAHPIVSSFITPYALNGYPLHFIAGDFFAGKSICGCTIDLGAEAGSMRLVDVLNTHMFAPGGEGDGIDGAHRVAQAWQLNEVVKEKLERGRHVLLMGDFNSQPYSIIMRILESGASLSDAWALTNQAPPSITSIAHRNLTPVQTMLVHGITCDSPLNTYSAAKLAKRHPRDETRIRGGKRLDYILFRSPPTASSKLQVESTKIVLTEPVPGLGVSYSDHFGLAATFSFQPQTPTTEHVSHLNQGSGGSISSEDLSTMLKNLMMAYRYALEYQKRQFQLFVLALFLVPVLAIAASYQPLRGALSWLFVVLGTAVGASGATMLYTGFVGGNWERGALRNVIADIEAEMERRDEDGQVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MR19</accession>
    <name>A0A2X0MR19_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C025g10034 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C025g10034</name>
        <name evidence="2" type="ORF">BQ5605_C025G10034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000087">
        <property type="protein sequence ID" value="SGZ27040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MR19"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ27040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="109" mass="12202" checksum="00FBC86E11F910D6" modified="2018-09-12" version="1">MAGKLACLLVRAFDRSLHTRVARVAPWPHKTTDAERAEAALARHENPRQTTGHALAGPVVRPLCRTHSRPPSLQQLIVFYPLERQVPTPPKHSFSTYRLGKRAPTRAPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MSG3</accession>
    <name>A0A2X0MSG3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C049g12433 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C049g12433</name>
        <name evidence="3" type="ORF">BQ5605_C049G12433</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000111">
        <property type="protein sequence ID" value="SGZ30694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MSG3"/>
    <dbReference type="STRING" id="796604.A0A2X0MSG3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="777"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="868"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="627"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ30694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="896" mass="97083" checksum="3687F3078AA9FC6C" modified="2018-09-12" version="1">MASTSSRYLRPARTFSGDSDEHSPAQPPRRHSRERKAPLRRPTPTLAHSRESSNEGDSESSHRGRNEFKSLDRESADAYTRLQRPGSSGFIRAETLPRCSPSTASSMSSIGSSFDLADSPAASLFFSPPPIQQARNVTFDKENVPNRKGMAGPRKLDLELQDRPQETMGVAEPRSANAMLQHVRVKASPTTFGFPFASSILATSDSFADLRGPASRTSVQDHARPSAATQGRSDPSRSDKSASSHRLSSDVDLDLSFDYHQEPEMVFGDEASIESASAEWIGIDMTGRPAEHDVPEGELVRSPSGRLLGTHKKRVRSAVDLRAQFRMAEAVAIPMIEDVPTEEALGTTQGLLIDESTHAPSGIPVGTFGRRVSAPIQIKRPTSWGNGFAFNPTNPLMVTLPDSPGFTPSPSPTLTTESKTLAAPFRFLERARSSIRLASPLSTPVLGRSSVDVKGKGWATPNGNLVGVNESLQQQTEGTTARRKNWASQLAQSAMVKWGSPTTSSHEARSATPTMTKFHSPLPLSVFDHPQHSASFETFNTAETTPIPDVGQFEKQRGARSDVENFAVSEALKPAEDLAGLGIAFNASDNEGRSIRQSLASRQARTQPSSEVVRPYGHRTIPSLSVTRPIEDGHETSSVTSRVSAVDPTASRRNSWHSGQYGDAIQRFSAPSVARRRSLYGNEALHVLVPQTSPHGRMAPQTGPASPRFSFTPAPLQLVKAHCPPPEVDATTGASISVQAPINSSLRHRRPHSVGSLLEATITRPGHFIETTVPSKLLFLAGFLLGPWCWIIGGWWLRPSDGELRRTRGTRCREEGCACGMMVPEDRLRGITQRHLTHSRGLKAHFTSVVGGGTDESIKWMGLDEWVFTNRVLAITSGVAVVVVVAIAMFEASMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MUW5</accession>
    <name>A0A2X0MUW5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Protein PNS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C067g12833</name>
        <name evidence="10" type="synonym">BQ5605_C101g13143</name>
        <name evidence="11" type="ORF">BQ5605_C067G12833</name>
        <name evidence="10" type="ORF">BQ5605_C101G13143</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 8">Probably involved in transport through the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000074">
        <property type="protein sequence ID" value="SGZ10925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000135">
        <property type="protein sequence ID" value="SGZ35335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MUW5"/>
    <dbReference type="STRING" id="796604.A0A2X0MUW5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF4">
        <property type="entry name" value="PROTEIN PNS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="245"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="482"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGZ10925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGZ35335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="546" mass="59291" checksum="41C9D13472CEC957" modified="2018-09-12" version="1">MATRQSPYPNLGADDNVVNQNNYAPPPQPYQMPHSQPYGAQHQQPQVGQQPYHNAGAGGQTSQSYQPPPLQQQYYQEQQQGYGDNTNGGNGKYSQDYGDKTQKFDAIKPKFNDIFFAIFFVAQMLGFIAVAVLVLRAVNVRADSLGNPGNSITLNLSTSYLLACIAGAGFVFSIILLGIVRAFVLIVSVAYAVYLWIEKFWSGAIIFSIFAVISVIAYFPMRKRIPLSKALLLFVLKIAKHHPSVYIIAMVGCLVQAAYSVFWSFVVIATYQKYHPGTAASSTSGGQPSQATMIGLIVFECFNFFWVSQFITNYTLTINAGVYGAVYFGGFDAKSVAWGAFKRASTYSIGSIAFGSLVVALLDLIRAGLSILRSYEEGQGNGIAALIICCVQCCMGCIAGLVEYFNRYAMIEIALYGKAYIQAAKDTWNLFKDRGIDALVNDSLVNSIWTFGSFAVGALCSAAAYLYLTLINPSYVQNNTSVRAAVMGYAFVIGFFICHALGYGALSSGVSTIFVGLGEDPEALAERDPALFQTIAQAYPQVTTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MWC7</accession>
    <name>A0A2X0MWC7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g02529 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C003g02529</name>
        <name evidence="1" type="ORF">BQ5605_C003G02529</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY41576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MWC7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY41576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="645" mass="73534" checksum="2BE87D639F28A54E" modified="2018-09-12" version="1">MSEGIWAKRADNSARRLWSALSPTPHPVFVDFVCPVVSRSERRLVELRVLFFHSIWKLCRRRRFSSDLLEPITETEFEGLRASIQESKGRLVSLLTRATRHRPRSWHPITGTLYSTKVSTKVFKMPVIINIEPSFALTSEEFAILSPVADLRLVDLLAYDLPAPDASLRLALSKDDPRHFDALPRPLKQSIGKFFNQSFLSLAYLDGYRSIAFAVSGSSAEKIRYIIHNIQEQVSQLANADAIREHELASARHHLTRIRWTAVDRVYLRGRSTRLQDFLQILSELRLVLRNTSESTVRQGVPPNVNEAGLNQVLDRLRLVGSEPLPCIMRREECDALLSVTALDIDQEALIDAVDAGFDQVDAEEEDRQFQTILAEACHEHEQSTRVPNQWEAPPYPRDLLEKGALYSVPTLDLDSLLARRRAHQCRHLEKIKFKGLKSRQWEWTGIDSLWRTRGTFASGANIREKTLQEQATTAIITEGRSHDKMKGRQEVYGQIMSNHVLVRAVDVSALRSLKVDTLVVYGIPEEPMGLPSGEQCGERLAIGIGMPNYYLLRNIYKKSSTTYESVEKLRVIAPEVYSNLSHQGNTRIRQVDGRCIINSLKPDLSSINYEVKDSTRSNWRDEGEIHITVNQEKRYRLLQNIKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MY62</accession>
    <name>A0A2X0MY62_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">H/ACA ribonucleoprotein complex subunit GAR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">H/ACA ribonucleoprotein complex subunit gar1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">snoRNP protein GAR1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C001g00594</name>
        <name evidence="12" type="ORF">BQ5605_C001G00594</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the GAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY47953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MY62"/>
    <dbReference type="STRING" id="796604.A0A2X0MY62"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034513">
        <property type="term" value="F:box H/ACA snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000454">
        <property type="term" value="P:snoRNA guided rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.230:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237:SF6">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237">
        <property type="entry name" value="NUCLEOLAR PROTEIN FAMILY A MEMBER 1 SNORNP PROTEIN GAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="37"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="275"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="287"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY47953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="354" mass="36352" checksum="3FEA5455E714B2B8" modified="2018-09-12" version="1">MLSTRSPLVHGAGDVDTYLPIRPTAYNNPNYAIMSFRGSSRGGSGDRGGFRGGRGGDRGRRFAKARVSAGARPCRVRHEDMGSTSTIVKAPTNSRQDKRTNQTTVLLPVMTLLVQTLLRDRPGPFAPPATALARFPYFIAGIDARVSRIFFPIPGGRGGFSRGGGRGGGRGGFGGGFNDGPPAEVVEIGTFVHAVEGEMLCSSTMPSKVPYFNAPIYLPTKAAVGKVDEILGPINEVYFTIKPSAGIQATSFTAGDKVCIGTDKLLPIERFLPQPKVPGVAKRGGRGRGAPGGARGGRGRGAPGGRGGGRGAPRGGPPRGGSRGGGRGFSSGGRGGGGFSSRGSGGFRGGRGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MZZ5</accession>
    <name>A0A2X0MZZ5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g04020 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g04020</name>
        <name evidence="2" type="ORF">BQ5605_C006G04020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY55414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MZZ5"/>
    <dbReference type="STRING" id="796604.A0A2X0MZZ5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY55414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="268" mass="29121" checksum="E6C1E449A65C7796" modified="2018-09-12" version="1">MEDKVEAQMTDEVFSPKPPTHGEVAALDQDLRTLYQTSPPSTHCSALATDAFALPLSQRPLKLAKPSTPATSSAMPSPGAPGVLKAAMELHTLAMFFAESMLYLHKAPFAQALIDYPDEPLEAPWSASVLAVILEAGPYMTQITKSWSELDPVLAPRWWHIYFHTFATTVVQSSLVVKCPRSKLVQHALYQITAAIDIFETAAVTGAPVAMLLPRAKSLRTDALRAIQSTRRIPASMRASNGLGVVSPPKLSKEPTDNFNRCILKSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N1I6</accession>
    <name>A0A2X0N1I6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C038g11658 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C038g11658</name>
        <name evidence="25" type="ORF">BQ5605_C038G11658</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000061">
        <property type="protein sequence ID" value="SGY91329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N1I6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="182"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="482"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="539"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGY91329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="963" mass="105805" checksum="A2C6CFF69A409664" modified="2018-09-12" version="1">MVADQSLFTTYRQTAHTKIGGIAGGITAIGMGDMAFVAKTGHPITLCCVLHTPGLHVNLLSVSRLCDTDRVRLAFTSDGIDIAKDGQAIAHGTRVNDGLYLLDADHAKCQQLAFLSRSESTVALLTLHRCLGHLAPSSIQKMIAAGLLDGFGAGYSDKDVEEFVCNACLGSKGHRLPFPDSESHSPERLGLVHSDVLSFPTPSLTGKRYLVTFLDDHSRKLWAYAIDHKSDVFPTFQTWLADVELETNTRLRVLQTDNGGEYQSNAFTEFCKSKGIHRQYSIPYTPQQNGRAEHVNLSIVEGVLALLADARLPATFWDEAAAYFVYCKNGCSHSALAKQTPEFVWNGQVTTATALHPFGCTAWLTVAPDLRSKLDPKAAHVIFTGYDLASKAFRFFDHSINKIVLGRNATFLDDDFPGLPVTTPVDVDDTDRQFVIPADTPTPAVKTRTPLVRSAHMDVSSSLDDSAMSAVDVAPGYTGGSLLNSTGTRSSSSPSLSPFLSPATSSAREPSLNNSDDPLDLLSSNTAVCLNRMDVHRSDDDTLETQAPAVDPIEQPSDDDSTDEINFLSRHHRAFIATENDDPTLEAIEPVKSITSDPQTWREAMSSDERDIWAQAAAAEFTAMRDDFKVFTIKPRSALPPGATIVTSKFVWKTKRDARGDVTGRKARLVAQGNRQRDGINFSETFAPVARFSSIRCLLALAAANGYHIHQADIDKAYLHSELDHDIWMTTPQGFDFPSDKVLRLRRSIYGLKQAGRIWNRHIDTSLRNLGYKATGTDHCIYSRIDDQQRPHYIALYVDDLLIVSPGLDEIECVISGLEQRYGVKRLGPAEYILGIQIRRLDNGSIALSEERYIMDVLARFHFDTTTRGTTVPMTPGLSLMAIPGRGMERIRSWYLQAIGSLSHVGTANMVADVFTKALGPKIFGTHCYALGLRTRHPRLKSTLRSRGGVCVFYSINSTTSAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N255</accession>
    <name>A0A2X0N255_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C007g04821 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C007g04821</name>
        <name evidence="2" type="ORF">BQ5605_C007G04821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY63709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N255"/>
    <dbReference type="STRING" id="796604.A0A2X0N255"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY63709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="204" mass="22640" checksum="2F3601AD50E26696" modified="2018-09-12" version="1">MGGLRAVHRLRAPEGGAIVFRGRVWPGPTRYTCGGEQAAHCSATASAPWMSYLVFRLLLSPPCPEPPYSLPLHHPMAVLPRLLIQLASLGFLYSAFIAWDGQSKTRVDARSSIKAEWIPPPSHRFFQAIPLPLPVRWRFVFVILQVLAAFALLTIGLLWSANSLAKISWASEMADKTIDTQDSTLGFRNVRTRASKLFQDRSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N3H0</accession>
    <name>A0A2X0N3H0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1</fullName>
            <shortName evidence="8">Oligosaccharyl transferase subunit WBP1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C032g11104</name>
        <name evidence="11" type="ORF">BQ5605_C032G11104</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DDOST 48 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000067">
        <property type="protein sequence ID" value="SGZ05020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N3H0"/>
    <dbReference type="STRING" id="796604.A0A2X0N3H0"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005013">
        <property type="entry name" value="DDOST_48_kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055459">
        <property type="entry name" value="OST48_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055457">
        <property type="entry name" value="OST48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23358">
        <property type="entry name" value="OST48_MD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03345">
        <property type="entry name" value="OST48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015800587" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1" evidence="8">
        <location>
            <begin position="27"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 N-terminal" evidence="9">
        <location>
            <begin position="28"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 middle" evidence="10">
        <location>
            <begin position="303"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGZ05020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="450" mass="50048" checksum="9EB29488AF04E546" modified="2018-09-12" version="1">MFSKLGRYVAVLCLYHIAAQIGSVSADKVLVVLEKDLEQQDYALTWSSLEARGHELCFRDASERATSTLEASQFQHILLFAPSAKQLPEDLNPQRLVEYTQHGKNLLVALSPHVSEFWRDFAREFDLEFDDRGTRVIDHFSYDVSLDDDSSHSVIVVPLSGCRPPFVASETGAGPPVLYRGIGHAVGRRPLATNILYAPVTSYSGDPSRVGNLVDDVHLAGTSTGLVTAFQAKNNARITFVGSTDVFSDVFQSASIESSNGLRQVDLALPNRYPRSGNTAFLSDLTRWTMQETGIIRIDATRHYRASDGQRQDLYRMGEELAYDVDLVVKDKDTDLSAHLDDLQLEFTMLDPHLRVPLTISGQSIHGRKGETAVRYTTSFHAPDRHGVFALRVDYRRPGWSFLDEKAVVSVAPSRHDEFERFITGALPYYGGALSVSVATLVLVILWTLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N4H8</accession>
    <name>A0A2X0N4H8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C005g03366 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C005g03366</name>
        <name evidence="2" type="ORF">BQ5605_C005G03366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY74506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N4H8"/>
    <dbReference type="STRING" id="796604.A0A2X0N4H8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY74506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="381" mass="41501" checksum="5AF02CA2F7F8097B" modified="2018-09-12" version="1">MTSVWSRNLRDEDDCGFDLDCYITATPANPWHQVPPPVAASFWPVAAALSVPDIAPRARRNHLLTGSASASARQRTVVPTQQTQDVVRFSQLPSDSAAMSVPPTASHRSPLKNLSPFQTGVTAVSPPSRNSHADRTDATQRPYLYPPARTCAGHFNPQPSLHSESSTRIDPIWSEAHLSKVSAVLRVEDRSQHPVRTTWSSLSTFSQSMPMSLTPSQPATAKIPRFNTQNTPSSSSTPLEQEVVAPTPIRLTPPTQVFVDQNSATAVPCAAPNRLEQSAPNPSWLEEALYGPPFGADISSSSHAPVTGQNRVTTRKAKVSRFKRIGRVWTRKTTAAPAPAHTMVAPYPHDGESKPSSTPQTIRRPFKQRGNRRTPPRSSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N9T0</accession>
    <name>A0A2X0N9T0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C034g11355 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C034g11355</name>
        <name evidence="3" type="ORF">BQ5605_C034G11355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000065">
        <property type="protein sequence ID" value="SGZ00532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0N9T0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="600"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ00532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2058" mass="233060" checksum="CE284B8DCD19F8CB" modified="2018-09-12" version="1">MVVTAWIGKKARSFYWIVFCRLPTAQQPALETQPRRDIRRCRGDDPVKQKKKKKAKGVAEEKRWSDHEPEDDVLPALPLFEDHTIITWNVRRGMGVPEKRRDIYNYLSLFKASAILIQEHFIRPHLWQLIKDEYEGKLFINQHCLTLIPADSPLIDAELLRTHSALDGRLLVTSFRLRGDIKILEINNVYAPVDPKQRAKFFDKLLFHKTQKSHLRLLGGDLNDCPRPEVDRRNQSRRGHHWPILIGKLDSAYTDCIRYKHPITPSFTRPNPNRKRPNSFSRLDYFLLQRTHQKRLDQASTIYDYPKELSDHRPVLIVLALSDDPDATLPQLSLPTTSNQLHRINTTTFKTVEFQRMMEGWLEGASGEEPVGELEVILKACRDRGGEMARRLHRERTERMEYLVGRVQDLEAIPEWGEAETAEWTRTSEELKRAVEERARLLRIRAHVPEIASEERLSRPVHAKLAARNSDSKITALRLSNGELTHDIDVALDHTQAHFQRLYHIEPRDPDRVDRLRDEFLAPIRAARTCDDPRSDPLFLRRLSESQIDLLQRPITEDEVVAAIGTTHPGRSPGPSGVPYELYQTAPKAWAKVLTKAYNAMIERGSLSPKQGQGLVRLIFKQHKKNADRAELSSYRPITLRECDYKIFTKVYVARLNQILPDLLPPQQHGFVKDRRSADAALHLRLLIEELGARRTEFPAAALLSLDQSSAYDLVEHDWIFAIFDALGAPATFLRVLRMLYSGDSTSARYIINGFLTAPVRLTCGLGQGDPASSSVWDIVFQPFLDALHRRNIALNLSIPALHPYPQSRAITSLAFADDVVVAVAGLGSLNLLDGLALDWRHATNGRLNTDKTVVLPIGRRWDPGQRPLVVKAAGESLEWIGLPFDPSGDTELAYANLIERLEATLEGVQHRWLTHHTRAFYVNRYAIPKILHFLAADIPPPEVVKKLDDMLVDFVRGGKGRTSYGRDIVFTAKLKGGLGVIRMQDVVDAVAARIWDVLLGGSGAIWQGLARAALQRAQSDLDLATDLWPHPSTPIPSDLHPRWRAALGVPKQQDAQVNPRTLTTANLLALPTLLGSLHTPIRGRQTIDAIHIPDYLRLQGYPKVADLYRRELYAGGGFHLWTPPADVLGDNSEYDRRGLPQRLAIAAWYRFTVDRHKNTPLAVAVAAGRLNVPPRIGTSAPLEAILPKPVARFAMEQRLPDPVLPQQASQYKLLNMARPYTIRRIRRVLNAKAFTNTLGLKGPPQPDDLRSFWKAVNSKALTAREREVWFKLILRFTPTRKLQHQQNHDTSPVCLVCEAPVDDTDHYFFGCVDSRNVWIAARGVLCDALGCDTIEDDQYTTLQRLFGLPKLKAKLSEQEGAGRTIEIFTGGRGNVYDRVDHAWIFDVFEAFGFGERFISLLRALYDPETLGVRYLVNGFPTDLVRLLCGLGQGDPLSCPVWNITFQPFLDALVRRGIALDLQKGWPGGPRAQLTHLAFADDAVVVVESPAALSKLETLSQTWYEATNGKTNTDKTLVLPLGPNWLRDETAQALPTVQEGESFKWCGYAFFRHGDSKPFWTHVLDRIKAKTRAAGDRTLSPSGKVFHANAHIISTVLHVLSFDIPPQWFIKAVETALTDFVWGGAGQNTVARDFVFQAREDGGLGLISIGDIVHSVALRFWDAVAGSNEAIWAPLARESWRSLVAATRDFSPWGFFSSTARVEKLYRDSTRWGAVVAAARVTVPTIKSELLTLPELLSLPPRLPSLYAEGAKHAYDDADAVAKFAQIADLYWRDEGKGWALVGHRRGFWQHSKEPALQHEHVWSRVGQLLKAKALLPKTALRPARIPLKEAPRPRCFNFFGLTRPFTIRKLHRLVNVVRFPGREDRVKRFRDGTSQSNRKRFWRWLHDRFASAVEQDTHWRLMYDVTPTRKRQHTQGYASSPTCLFCGNDAAVIETVSHYFFECAYSTSFWGGVLRILFDKLGIEDTDVDPSTFTPEQLTMGLPLLRGRGRTTSKWMWVRLACAIGFQRLHLLRWRVHQRFELDKVVAPPSLPSALRAFERDFLSRAGFVPGARDWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NBB0</accession>
    <name>A0A2X0NBB0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C028g10476 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C028g10476</name>
        <name evidence="1" type="ORF">BQ5605_C028G10476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000080">
        <property type="protein sequence ID" value="SGZ12075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NBB0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ12075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="36" mass="4427" checksum="B610BD8011610690" modified="2018-09-12" version="1">MRPLTSEKHEIALEPHWFRVQTERIKRCNSQAKKDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NE65</accession>
    <name>A0A2X0NE65_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Endo-1,3-beta-glucanase btgC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Laminarinase btgC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">BQ5605_C023g09757</name>
        <name evidence="17" type="ORF">BQ5605_C023G09757</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation. Active on laminarin and lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="4"/>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ24989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NE65"/>
    <dbReference type="STRING" id="796604.A0A2X0NE65"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF17">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BTGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="145"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00043078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="SGZ24989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="525" mass="57788" checksum="929928F8F730F73D" modified="2018-09-12" version="1">MTVPSSKMPSSDRSNDVASAAYSDKTGGECEFRSLIDFNNHSPSTTLFSHPSPPRAVAMIPPSPPRPFSALYSSHMMPYSRLDASSIVKEAEMQAPTDEKRNPWSAQNQKRKAHRRSLYVVVIVSFLIAGAIAGGIAGCHFTKSGPRANRSRSDDASSNSGTPIDGTNLTAPPFIPIPATAQVVRSKPSDPSQFEPDPRLTRSFYGLTYTPYQAQEPNCLVSQLNVTEDVQLLSQLTTRLRLVDVACNQSQMVLQAIRETRVLMGVYLGFGLGQDQSRIERQKQTVWAAIRAFGGNGVRGIVVGNDYVLHSANRQRATQILTNHVSDVGQFFFKELDFKPLTFDVLNAGQLKARLNDLPLIRTVPVGTAEDAFSISPQLVAGVDFIMANTQPVFSGIPSLQASTWITSTYNTQVLPKIEAQLPRRPHFASFVTQIGWPTDALPLVNPAMAYTPAVPGVEGLQNLLDGFLCQANQQRMKYFFASAYDEPWKTYLGGFEPYWGLFDSNKQLKNLTLPLCTMDAVEHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NGK3</accession>
    <name>A0A2X0NGK3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mannan endo-1,4-beta-mannosidase</fullName>
            <ecNumber evidence="4">3.2.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C050g12466</name>
        <name evidence="11" type="synonym">BQ5605_C084g12998</name>
        <name evidence="12" type="ORF">BQ5605_C050G12466</name>
        <name evidence="11" type="ORF">BQ5605_C084G12998</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random hydrolysis of (1-&gt;4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.</text>
            <dbReference type="EC" id="3.2.1.78"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.78" evidence="4"/>
    <dbReference type="EMBL" id="FQNC01000039">
        <property type="protein sequence ID" value="SGY28630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000097">
        <property type="protein sequence ID" value="SGZ29652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NGK3"/>
    <dbReference type="STRING" id="796604.A0A2X0NGK3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045053">
        <property type="entry name" value="MAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451:SF39">
        <property type="entry name" value="MANNAN ENDO-1,4-BETA-MANNOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26410">
        <property type="entry name" value="GH5_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036326518" description="mannan endo-1,4-beta-mannosidase" evidence="9">
        <location>
            <begin position="19"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="10">
        <location>
            <begin position="255"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF26410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY28630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGZ29652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="440" mass="47683" checksum="7547033957EC37F0" modified="2018-09-12" version="1">MRWTIALNLALAISSVAAQGLPPGPLPAKTALKEQKVDILRRSDDDVTNIADILDEPSAPLSEATNEIPASRTAIRFGSSSGGDRDAVAHNPLITAPAKRGCAPIYSGSRTTIKGGNFRIIGTNIYWLCNDENVGLPKGLPTDKGRVREALAAAVAFGANTVRLTTCATSLGSPTLLQPNATNFADEIYWDIHDYVLFAAREYGLRVVLPLTDNMACFYTISYEYYHGGKYTFLLWKKLSSGQYGAQFLTNSQASKYSRVQYKNEPTILAWETGNELGAYFGREGYPPQAWTGKAAGLIKGLAPNTLVIDGTDGLWNYTTGAIPQGGKLSTVDIVTDHVYPRNWGIIKKDISIAQGFGKNLLLGEFDWTNSNGGDSLSSFLTQALKQPTLGALPYSIYYPNGNSASDQQKVLQLSQFFYKATGRTAPRTLVVVACPQPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NIE3</accession>
    <name>A0A2X0NIE3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C040g11841 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C040g11841</name>
        <name evidence="3" type="ORF">BQ5605_C040G11841</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000118">
        <property type="protein sequence ID" value="SGZ32271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NIE3"/>
    <dbReference type="STRING" id="796604.A0A2X0NIE3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040441">
        <property type="entry name" value="CFA20/CFAP20DC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007714">
        <property type="entry name" value="CFA20_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12458">
        <property type="entry name" value="ORF PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05018">
        <property type="entry name" value="CFA20_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CFA20" evidence="2">
        <location>
            <begin position="83"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ32271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="271" mass="28895" checksum="CBAB795102E35B4F" modified="2018-09-12" version="1">MFKHTLQVASTSASFAEDSWISLVDDATDQLIPSQPFPSSSSATTTTTTLGTPSQSTMKVGSPTTPSPTSTSTFPTTSSSKGSISGPVLHLQSPDIKTTFIRFGDSPSNTGASSSSSSGLAINAPYLHLFLKPLGQGTNFYLDVLVTDERGNSYVIRASTFQTTPTYTPSSPTHPHPSLLHLPLSFPPPTAHSLTPWLLLSLPLPDHLNSLPDLGGPSPPPRYKALQSIEVHANCRLKRVWCTEERGGGVVQEGMALRGMMTELCLFEAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NIX8</accession>
    <name>A0A2X0NIX8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C075g12923 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C075g12923</name>
        <name evidence="1" type="ORF">BQ5605_C075G12923</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000128">
        <property type="protein sequence ID" value="SGZ34819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NIX8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ34819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="186" mass="20494" checksum="EB5779123320F2CE" modified="2018-09-12" version="1">MDQRGCAIILDDVVGKLFEDLNDCYRDFERQRIDALGWPNDGSTPQLDAALPHQRYHLQTARSIRRARHSVVMENANSTVLNLLDFKDYTLVDTGNSSADLFSLANNDVILLGESSFGALAHLVAPPKGLTIVEGADEPNKHRDSTRRSLVLASGRIADFVQMIIENFPGGPDENGVKRALTSALY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NMA5</accession>
    <name>A0A2X0NMA5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C010g05981 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C010g05981</name>
        <name evidence="10" type="ORF">BQ5605_C010G05981</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NMA5"/>
    <dbReference type="STRING" id="796604.A0A2X0NMA5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089701">
        <property type="term" value="C:U2AF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000066">
        <property type="entry name" value="Splicing factor u2af 23 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009145">
        <property type="entry name" value="U2AF_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12620">
        <property type="entry name" value="U2 SNRNP AUXILIARY FACTOR, SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01848">
        <property type="entry name" value="U2AUXFACTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="9">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="73"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="9">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="197"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY13801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="247" mass="28077" checksum="8964AAB464DB5AD2" modified="2018-09-12" version="1">MSYRGGDGSEQDKVNCSFYLKIGACRHGERCSRKHIKPQFSQTMVVYNMYQNPAIAQGSSSNPHLRPPGSAPLDPNPKSDLSEEQLQDFFDKFYEDVYCEFVKYGNLLEMHVCDNVGDHLIGNVYARFDWEDEAQAAVEALNTRWYAGRPLVAELSPVTDFREACCRQNDLGNCDRGGFCNFMHLRHPSKSLLRELQREQRQERIENPDPKEEERRKEMEMFGGAGGGGGDGDDYGRSPPRGGSRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NMC4</accession>
    <name>A0A2X0NMC4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C010g06001 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C010g06001</name>
        <name evidence="1" type="ORF">BQ5605_C010G06001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NMC4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY13908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="428" mass="45424" checksum="6751350ADED63554" modified="2018-09-12" version="1">MADPARVTRRLPGAELERRRRGLVEAIEVVEVADDSDVPPDKGDAGAEVEGEGEVGVETGAAVVVCVSFVGPVVARVNVSFPVSSPSGSVEATDSPSSSSSSLSLYGCIVMSPTSNQAALEPSSSALISRIHLSDNPNSYEEWSVWISNHLRRKKCLDVTTVGIPALLAIYEAALVTPSTSQATSAGAKISPAAPRALTSAQQGLVDIYTLDLEAKDDKAAELINNTITGSQMKIIKNCVSAHEMWTALRIHHTKGAEARFIQLVPVIFRSTFTRSNTSNFKSFVSNFLNAVEEISTMGVPLPGFAQAALLVHSLPPEWESIASSLTTDLTLATDIDSFIAVLYAQVDRKMASSSTTHGAERHAYGGIESALAMSAQSHDHSKVHCKSCNVMGHSSKWAGCPSLKKAQAVKEEAAKAMFVNSAFCHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NNJ0</accession>
    <name>A0A2X0NNJ0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C013g07173 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C013g07173</name>
        <name evidence="2" type="ORF">BQ5605_C013G07173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY14939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NNJ0"/>
    <dbReference type="STRING" id="796604.A0A2X0NNJ0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="555"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="424"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="555"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="598"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="637"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="654"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY14939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="681" mass="72275" checksum="76A93970DF7F2020" modified="2018-09-12" version="1">MQDEVELQAPRPFPHQGSFWTTYWSTPEKTNLLASEVTPRADEERCVYCRDNDIDVCWQIRGGVVCLECKFAKRRCADCYGRRPHANDADQWFTSELDYLRVAENPHKLVKDILDKLPPAERERAKDEFDQFPRYARKQGDHDAAKNGSNTSAVHSTPVKRAATPTLTATTPQLIASTSTSTKPAVASVAKAKDREVGLQGFKRSMNGSGIKRSTTPEGSPPPYDPRKMGLIVNADRPSAAKKRRVAPPPIQVPSAPVRSTTPEGTPPPWPPAGWIPRFKRSTTPPGSPPAHWPWPSVIATRRINYNIPASSKARVIRAQRFCEKMRDVLDKVDKEPNTDTDSLLTAIGRLGIGFGFGYHETFKKGGVLDEWWNGEQPDSPHRLIYARINPENSRDIGIAAPRKFNLTRAVSEVKAPRKRKSSAAKAAAGSPAPVGVPASTTPPGSPTLIPLPVYPPFILGSALASSASSTPTPDESKVAAAVKPAVNGNAAASVTVPSKRKAPASGRKTQPLHTSGTNGKPMAPPAAKIASVIKNIPAASTSKFAAPHQVLAASKKATKKTTPTAKPSTQLAAGEHTPARTATSKLVASISGNSDISTPTPAAPAEVATPASVPAASPAPTPVSTLAPRPAPPPESSFSFAAAPPKGSLKLGTSTNSALAAASSVTRGTPTSAHKSARRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NP42</accession>
    <name>A0A2X0NP42_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C013g07373 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C013g07373</name>
        <name evidence="4" type="ORF">BQ5605_C013G07373</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NP42"/>
    <dbReference type="STRING" id="796604.A0A2X0NP42"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="227"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="227"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY15460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="274" mass="31603" checksum="635951109E0C01DF" modified="2018-09-12" version="1">MQDRKTLLTEAFGSEVAEAFDQNLDEYQKLHFEAYKVKVASQRTNFLERSKIAAKVPSFWARSLQNCRQVAELIDAVDEDVFNHLSDVWIQHDDKDPRNWEITLTFDAKNPFFSNKTLTKKFSIEHPSSTTPAKPYDLEAPLYLLAPSKEDAIKWTSDEHNLVKKAPRPNLEDLEEFDEFDGAGSFFNLFSEDGEDKMGVGEALLEWFAHATEYAAGLSFLFENNDDELDEFDQGDLDDEDEDDEDDPEDLNAEIDLEQEEEDKSRPKKRSKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NT00</accession>
    <name>A0A2X0NT00_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C011g06449 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C011g06449</name>
        <name evidence="2" type="ORF">BQ5605_C011G06449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NT00"/>
    <dbReference type="STRING" id="796604.A0A2X0NT00"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY12271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="303" mass="32764" checksum="DB510B0713EC8817" modified="2018-09-12" version="1">MSPTFKHIGNVNDLSAPRGCSRPSAQLNSVSNRTASAQPDSGFNRTVTANNNFEQSQIRSSTPTTPSQEAAAQNRSTRRCARWIVKSTCTGSRQSQSPDLSRDAGPSTDATATSATTVVNWRPAEQRQQHQRAREQSSQTVPTALLPLPEGPFPRHDLGSMTLQCPICLALHWEFEKSPTPGGATPFKLCCADGKVRLPGIEKPPPELLELLTGNGPVEKIFRDRILAFNESFVMASFGMSKGHGIISGAGPSSFYLSGTVFLRISTLAPGPADDPVFAQILFLAPTKHIEARRRFNGPPEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NTY6</accession>
    <name>A0A2X0NTY6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C019g08928 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C019g08928</name>
        <name evidence="3" type="ORF">BQ5605_C019G08928</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY23345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NTY6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="573"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY23345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="624" mass="66850" checksum="4CD88DEA55793051" modified="2018-09-12" version="1">MNDSDQTNSTQGPCDDADDVNPVGSLGSDVANERLVPRVPIYYDRQFWFTFTNASLFSSTPPTSPALSLPIAFSIPQCSLIAWQNNCVSGENTVPMILMVVPINSKTYASALFSQPIEPTRYISDSQCGDGTHWDADLPVGQRVLFGFFDANGHYGGLTRNPYIITGPTLALTSTNNPKNKTGPPCKMAAELSTPIELVLYPPSNPCNYLLLQIKGGHGPYTLTILNPDKGTWADVSVDTTSTVLLTNISDPGSTITNVPYEPISPSIVFAVDKNLVRSQVTGEYKLGFPGTCNNTMDNSIEHSFSDSDLVATRRNFHLELIIPTAVIGFICLILCVLAIRKRDLLAQKMRRWRGVVLRGSSMMDERVQTGSKTIIKPDGPSSCSLPSNCTPVHSQSKIQLSKAEMSIHHGNGYMNEHGALSTVVALSGTVDPRTTMPDKLRKPPHVVSKPRHSDTLTRNYNAGDSSVELMQLAIPGSGSEGGGPDSPDMGTSLGHAHRSSVPKLLIPADSALMLESGSDTEQAPTTIGLADPNEFVYRNAGWNLSTNRNTSTSQAAAAPGLAASAPVPPLPVLPAIPPTRSPQPAVQSPPSLKRNSTTPPAMQCPRFDRGSGTNHVSIASIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NU44</accession>
    <name>A0A2X0NU44_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C013g07217 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C013g07217</name>
        <name evidence="3" type="ORF">BQ5605_C013G07217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NU44"/>
    <dbReference type="STRING" id="796604.A0A2X0NU44"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019236">
        <property type="entry name" value="APP1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052935">
        <property type="entry name" value="Mg2+_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208:SF3">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09949">
        <property type="entry name" value="APP1_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidate phosphatase APP1 catalytic" evidence="2">
        <location>
            <begin position="592"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="756"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY15035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="898" mass="98010" checksum="123B7669F80A1379" modified="2018-09-12" version="1">MSTYYAAYTPRPKSSAAAAAAASSSGTSGTRPSSLTTSAEAPPLLQPPAAAYIAPLTPPTTRPCTPAATQGDSAMPGPTSYTGSFLRARALAKVHKFTNDVSPHLESAKQSAAGKLAQLRDLQHDRDAWGDDPRMAKQVKQRQRDYADPTRRDSSSSTVSASPTSTRERSGWIAGVSSYFGGGGNGGPSSSRQASTSAYTDEKVVCFPGWATLRPSAHSASEPALVLEIVAHGYAYRLRPVSQASRSQRIFGSLARSFAALPRLSTQLPPNGQIDSTQPMDILPPPEAIKDEALLDGNIFERLLDIGGREGTSEEEAELARATEIAAEPETMTSEEQAKSPFKPGATTEQDSPHRVALTPAQMHARATEDTHGHPQVHVTPASFTSSAQHTMTPPSRTHADRACTMPSTSSSLRASRASSISSQATTLSSRTAPTRPASPYRDAVYREEWPKPFEFTDSDLPRLHSNLQDRLLPFFGQKLPNRKVRLSVVPVFDDADPTWDRPLATKVVSTLGGGAFRTVLEMRSKELRRLLEATGKGVESFETLRVRIVAELLEHDPIVDAMSGGAFTGDQGMKVVAEDFTELAVAHDGGVRVISDVDDTCKHSQVVEGTKTLFRNVFVRELYEVQVPGMSSWFRKMEAQRCAFHYVSNSPWELWPVIRTFLDLAKFPKGSVTLKEYGGAGSALAKLWEEPGMRKRANVENIIKEFHHSQFILIGDSGEQDLELYTQLASEYPDHILAIYIRDVTTPFSPNAHFDLTHLSSQHPPHNKSDLMDNGQANPTQKSVRPPIPPRPTADSKRSSFLRRGTNSRPSSPPLIDADSDPLSPNNPLRATPMTPTVAEEAQMRIDTFYARIAEAERKLPRGILLKIFRHGKEVEKEALEVIKFGQTGGVPSDRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NVF8</accession>
    <name>A0A2X0NVF8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C002g01084 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C002g01084</name>
        <name evidence="4" type="ORF">BQ5605_C002G01084</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY29787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NVF8"/>
    <dbReference type="STRING" id="796604.A0A2X0NVF8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007065">
        <property type="entry name" value="HPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058581">
        <property type="entry name" value="TM_HPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33741">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33741:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04982">
        <property type="entry name" value="TM_HPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="HPP transmembrane region" evidence="3">
        <location>
            <begin position="229"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY29787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="462" mass="48822" checksum="E3B76CA66335E726" modified="2018-09-12" version="1">MVSPFFTLGRSSRALPLSFPTACVHSIDTNPSTLASMTSVAASNPIPVPQPIHHRTGFEREASLSPLRASATLGAGARRFSHSRGRPSTIGSNIRSESISLDRGSDSGSRAPLWRVLRSTSRGGTANTYGGAASPGRGAADDSPPRSFNPTGTARPSHHRGSDATSTTIVSNVHRPTWVERLPPELAHFLGHRPPIRRARSGSSLDARLDKPLSSRLLTPFAFLPKQGENILITWLGSFVSILIACALSSVFAFEWTQVLPLAIGSLGATAVLVYGVPEGPLSQPRALVGGHLFSALTGSIIGLLFSLSPKWSNANLASRNEFSGLVPVALALTVATSISVMQLTKTVHPPGGATALIAVTQPQRWAFVLLITSTVALMGLWGMIINNLGRGRRYPVYTAPPSVGMSTSKTDETELKETLPPGISIENGEGGDRWLGPVGEELESGGEEEVTRGRSSTARRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NVL0</accession>
    <name>A0A2X0NVL0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C012g06960 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C012g06960</name>
        <name evidence="9" type="ORF">BQ5605_C012G06960</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NVL0"/>
    <dbReference type="STRING" id="796604.A0A2X0NVL0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20908">
        <property type="entry name" value="SUF4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215:SF0">
        <property type="entry name" value="BUB3-INTERACTING AND GLEBS MOTIF-CONTAINING PROTEIN ZNF207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215">
        <property type="entry name" value="ZINC FINGER PROTEIN 207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="172"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="349"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY16714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="361" mass="39253" checksum="6756B84798E68113" modified="2018-09-12" version="1">MGKKSKKNKKSTAQSWCWYCDRTFEDDKVLLLHQKSKHFRCPHCPRRLNTAGGLTVHIDQVHKLGQPDKIENALPGRDTFEVEIYGMEGIPAADLAEWKKKQEEELGVTAEQQRSKKPKYDHRPLSASEIRAQLAQHKALMSGQPLPPMPGQYMGPPPQMQMQPHGQPMMPQGFFNGPSYGAPPPQHQPPHNYSGGPPPNFSAPPPGFIPPPPGIPLPPPGFPGFPPGLPAPPPGFVAPPSGFLPPPGFSAPPFLPPPPGMPLPPGMPMPPPFNPALAAVPIPKPKERLPSSAVELKPGTLLVYGDNEVSIEEKRARLAQYRVEIPKNAPEQEVGGITAAVNEASRNTGETRPRERAADLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NXS6</accession>
    <name>A0A2X0NXS6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C015g08006 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C015g08006</name>
        <name evidence="2" type="ORF">BQ5605_C015G08006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY18203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NXS6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY18203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="234" mass="25795" checksum="CA7B570BDFE60AE9" modified="2018-09-12" version="1">MQIRFERNPEHGCNEQDSDEEDEAEANSRHHISSFAFEQARLAWSSLDFFSAPPPLHPPREVILDLLDPYLYVKAGGASLLDQNHVEWAEPLTHPCSPPLIGPHSLIVPEETKWTVKAGHVFPLVVQCDADVVGKPACPQYIIYLRGPVAEAVPSIPSLYQHNSARGRTQIKVTGVRGDPNHPSCPDENRHWYVKGSGHATLHVLPSVDSTIVDEMKECDAADYEGPEAADGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NY15</accession>
    <name>A0A2X0NY15_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C017g08352 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C017g08352</name>
        <name evidence="1" type="ORF">BQ5605_C017G08352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY19856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NY15"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY19856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="136" mass="15279" checksum="0836364C892A2324" modified="2018-09-12" version="1">MVRRCGWGPRPVGFSGQIGTHFGHVRLGKPKFADPQEQLRASLAFPATSRRRRLCHHRQYPTFSARLALTKRRGPDIDLFDDDFEQMAPLLDVRVSELFASSFDKPANAPGFSLNSFHGRQTSLSSLNPLLGRSML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NYZ4</accession>
    <name>A0A2X0NYZ4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C016g08150 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C016g08150</name>
        <name evidence="3" type="ORF">BQ5605_C016G08150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY20820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NYZ4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY20820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="165" mass="18951" checksum="15F06018D896BF56" modified="2018-09-12" version="1">MTATAERVKHHAEDEDLAYRLQIMGAREGAIKGTLVAGTLVALCNWRFPWMQRQTLAGKAFLTMWGTIFGMVTHADHYLLKWEAEHRRKAEEWRTRARIELAAQGLVPSETTMRAWKKKDDERKADEWARKQQAQNQTTATSTTTTDAPVVESKILQELQNRKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NZ49</accession>
    <name>A0A2X0NZ49_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C017g08523 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C017g08523</name>
        <name evidence="1" type="ORF">BQ5605_C017G08523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY20200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NZ49"/>
    <dbReference type="STRING" id="796604.A0A2X0NZ49"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY20200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="163" mass="18249" checksum="A9B6DAFEFFA30D73" modified="2018-09-12" version="1">MPQPAGYICGFELYGWGSSIAQVFTNYNSHTTFFVNGYNYACIYDQADDLIKRYNAGHTIAIETALKKILGTKPKLFRPLRNDGHTTGPQSVKLYNKLANSYPKPHIALNHEVYKSTGETVVPQVVPMLIKKDVLKNPYQSVGKASKRDKTWTCQGTPKPHAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-10-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P0J4</accession>
    <name>A0A2X0P0J4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C001g00651 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C001g00651</name>
        <name evidence="4" type="ORF">BQ5605_C001G00651</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AFG1 ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY48438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P0J4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040713">
        <property type="entry name" value="ZapE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169:SF6">
        <property type="entry name" value="AFG1-LIKE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="ATPASE N2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY48438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="542" mass="60693" checksum="C4C8D208FD561AB4" modified="2018-09-12" version="1">MASTALRIPVLRVGSRPCSCPQSVLGQQPTLGTCRSSLAVQHHPFHHRAATPQLARSTPTRVVGFTKNPSASASIRRHLSAFPPTKPAHVQGPTAAYDHEVSTGLIQDDPHQRSIVALLQDMYNRLEAYRPPTIPPLPPPRKPSLLTRISRSRFFATMEDELHQANTATIPLPPAPPRLPKGLYLFGSVGCGKSFLMDLFYAHLPPKYEHSKRRVHFHAFMVDVHRRGHKIKQEKGEAQDWIHLAARDIAKETTVLCFDEFQVTDIADAMILRRLMESLNAYGVVTVMTSNRTPDDLYKNGIQREQFIPCIELIKSSFVVKCLDSEIDYRKVPRALSKVYFTPIDDAHRLQINKLFDSLTSNEPVTSDRKLTVWGRPIIVPESTSSVAKFGFNDLCGQALSASDYLEITKTFQTIFLTDVPQLGLDTKDQARRFILFIDAAYEAKVGISQFFLFDYLMQTKLFILSEVPIATVFSDQKGKRATDEISDHQRALMDEQGLSADVVGASSIFTGDEEVFSFARAVSRIAEMGGVQWARISKISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P5I6</accession>
    <name>A0A2X0P5I6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquinone biosynthesis O-methyltransferase, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinol 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.64</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinone 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Polyprenyldihydroxybenzoate methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.114</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C001g00196</name>
        <name evidence="5" type="synonym">COQ3</name>
        <name evidence="7" type="ORF">BQ5605_C001G00196</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol into ubiquinol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-methionine = a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="2.1.1.114"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="2.1.1.64"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinone + S-adenosyl-L-methionine = a ubiquinone + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:81215"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:19654"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:231825"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.64" evidence="5"/>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EC" id="2.1.1.114" evidence="5"/>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY44748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P5I6"/>
    <dbReference type="STRING" id="796604.A0A2X0P5I6"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061542">
        <property type="term" value="F:3-demethylubiquinol 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120537">
        <property type="term" value="F:3-demethylubiquinone 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00472">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010233">
        <property type="entry name" value="UbiG_MeTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01983">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS O-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 5" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY44748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="430" mass="47803" checksum="6D0D2C7ADCDE93E4" modified="2018-09-12" version="1">MQRTTTLAKTTISRRVAASSPQLWRSYSCTRALQYSTSSSSTSAPYAAPYSTTSSSNSKTNTISASEVAHFSSLAQHWWDPTGEFKLLHRMNPSRIRFLRDRVQRVQEIDIASGKWLDGFSVLDVGCGGGIFAESLARLGATTTAIDASEINIKTATLHASLDDHLTHRSKLEYRHCAAEDLVQEGKQFDIVCAMEVVEHVEDPRAFLGCLAQLTKVRVKICALAEKETPRIANADPNVALCSLPHSFTSIFSRQPGGHLLLSTISRTPLAHLLTITLAENLLRFVTPGTHTYSKYIKPSELQHFFESDLGWPRGTMERRGCVYDPLKGDWRLFGMGEWGGLAEGITMRASCTILDGFCQGGETSPFLIKHLEHRRRWLSDTGENRTRIPSLRPTSVAVQRSKFTHEVKVLTSLELSGPPDSRRIRKSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P725</accession>
    <name>A0A2X0P725_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00875 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00875</name>
        <name evidence="2" type="ORF">BQ5605_C001G00875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY50357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P725"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY50357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="854" mass="94269" checksum="E09F1B7A70477401" modified="2018-09-12" version="1">MSLEMAPKVRPRSSASPVRGGKRRNVPDVSRAEPCSQSSKCTTCNVQPPLDTSSDTALASCIAILSYALTVVDIVVDIVINIRLVVEVKAVEVSTVVTVVMALIITLPVDMAIVDIVKVVSALDTTVNVLCPWINHTVFGFFSSLTDHRSATGRGSSIRPRQRSCGGALGARKGCHPACRDSCDLGLGARSQQTHFVSMAQRAQTLAKVIRPGQNKATRDLHRDRLKEEHKLVMATGARSWVQGMARKAQEPANGRRGRPKFKLALGMCSEYSDVEEQDLSSKHCMHFLACDWTKIDKSQVPWERVLVPFSFGLSNPTPRGERDRDYVKRAPQLVNLILDLHDHVLPRPSRLSAPGLAVNEHDAHLVVLDHDGCRIAVISDCWGSGYGKLSATLSILLDLDVYSAGFAPFLRYKFPLRGGVTAVSLLSAVFQSSSQHDNHDQQPVETRTRLVGHTVAFEDEEPIELVSCSTSDSNSVFGPCTTVFRLTRPSLHESEGETGGHSFVLQMQHVSPNFVGGEAEMLQSINLAHDSGVLPSETVNPLAMLEVAASLRPHRSQVDDYLLPRRIAIDRRGYARDPMLSIKGIRRTLDLLILRNPTPVPRILASAPGMSLDSPAPLEHVLHVFDQLLTVLVALHRCGFYHRNLALDNILHYEGHLVLTGWGGGVAARPGEVVFAAKIDEDDDLWMTPWTAPLNVLRWNMFVPGDDPPNYDLSHALESSIYWFLLVLGQLIAPAGEGIWSELLLQPDPARDRNRPVLFLRRDALWAGEPNFAFESRDLLLASIGLTHPALADLVEYMTRRLPKLDARRIRTETAVAAIQRRVRRLAQGTDRRRGLGTIVEAMSDAYYSWARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P965</accession>
    <name>A0A2X0P965_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g04341 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g04341</name>
        <name evidence="1" type="ORF">BQ5605_C006G04341</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY58111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P965"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY58111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="168" mass="19187" checksum="346DFE6C897D8F3A" modified="2018-09-12" version="1">MGRVDRKQILAKWLNGSEVSAAHRKPSDVKFPAWYWRKTNRILYHSKVRYDDRIRARLVTVRVGDFVVFGAPSDSRDRVVFAQVEAIFSVGRDEKFTLLLVTCMDESQTRKLGYLGQVRVLEPFHAGTAERPRVIGLDAISSEQGVPILRDYTELGLHIIVPYQVSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P9T0</accession>
    <name>A0A2X0P9T0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C007g04683 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C007g04683</name>
        <name evidence="2" type="ORF">BQ5605_C007G04683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY62379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P9T0"/>
    <dbReference type="STRING" id="796604.A0A2X0P9T0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="818"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="686"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="721"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="762"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="862"/>
            <end position="881"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY62379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="950" mass="100124" checksum="7EB2B5B20FA3A4AB" modified="2018-09-12" version="1">MVVGAKGGEERGQRRSASVSVVSVLRSVGVALSLLRQATYSFVSPSSSSLAGSVSSLTDPSRTPVEDHARSNRIASLVTPKKPSTPTPTRPPNKQDATGFALVDYPLSAASSPLSKPAQSPRQDLVEPEPELEPEPEPVASTSTLTSVEPVSPEKVATRFPTRSSSTRNQDLASSFPPDWVSAPAPAPAHDPVPVPIVETPTSTRIAPRRSARSSVATRDVVLGSVAFEKHPKTKAGMVEEPIEMDVDTAEQLKNTPAQEEDMTPSKYPLPPAVEAVTSTSPKVATPTATPSPRKVATKTITEVEEMAESLAEPEVEAPRAVNRLITSPLPPPPPEPLPTPEQPTIVDTRIPELLPGPIPTPAPPAAGPLQRLLNPVRPPIVPSLPVSPTTERPPPPEPPTPPPPQTQSPVEAKDQVEPSPPSPETTNAQPSNSKVMLPAQSMIRKTAQGGLSFKRVVDVPVESDRSGVEDEEQRGVGRGSASGSVIGETSVSLDSSNGMDVDSTGGKEQVLISSVRPKRTYQTKGKGNAKTNIKAVDTIPAPEPEPEAQSNHIEPNPSEPVLVDAPTTLADESVPEPITGVVFLPTKTDNVEDIFNDDSGDEFEQVIGPKVGVKQVGEVNGDGDGEKDGQTEVEVEVEVEGEEGLPKLKLKLGDKGNKGPKEVKGSTPVSNVTTTNKGSGVGKQTRKEKEKEKVKGKEKDKPDPSPKKRSHPEPSVPGPSSKKLVTSTSSKASTPLSTVSTPGPTTTTTTTTGNGSGGGTPSATGVGSSGRPLPSSSSSSGIDLSKMNKIKSSVFHSQAKKKSNTVANPLAQFLAPKMAPGGGAPGSGKKASAMTAGKGGKGEEEGGSGRSMGVGEYEPATEEKHKEMAERRIREREERERSRGQGFNLLAQIDSMTTFEHKYRSMYAMRMNEARFVENRPLPRAQTFGAVFSYFPSKLEKGDEVIGAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PB22</accession>
    <name>A0A2X0PB22_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C004g02856 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C004g02856</name>
        <name evidence="9" type="ORF">BQ5605_C004G02856</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY68145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PB22"/>
    <dbReference type="STRING" id="796604.A0A2X0PB22"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001136">
        <property type="entry name" value="Beta-catenin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039678">
        <property type="entry name" value="CTNNBL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013180">
        <property type="entry name" value="CTNNBL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978:SF0">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1 NUCLEAR ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08216">
        <property type="entry name" value="CTNNBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01156">
        <property type="entry name" value="DUF1716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Beta-catenin-like protein 1 N-terminal" evidence="8">
        <location>
            <begin position="115"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="624"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="234"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY68145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="652" mass="72120" checksum="FDACEB36995769D6" modified="2018-09-12" version="1">MDINDIFKRPPLPPSGAAAGTKRKLEAPTPDMSSFKQHKADTNPTNGAPPAATSANTNGKGKGKASVTIRDGSDDDDHDQDGDNDGAPDEEFAPGNDADYFAEEDEDGRFFGGGLNSVQKEVLNMMDKADDKFAASGELTAPGVRRQLLALEKAIDENRRLRTKFPTDPTKFVDSEFTLIEALNALLVLSSFPALSYPILIELNTPESLADLLSHENTDVSNAVVEVLEEWLDPESLDEDDEEEEGGDEGGSERKLEATKKLVESLIQFGIVELAVSGLARLNEEDESERGGVFHILGLLENFISLTPVIATSLLAPTATLLSYLVKRLSMDNKPADWDQNRFYAAEMLSLLLSLPVDGVAEGRKTLAEQGHVDALLKIISTYRRRDPSGADETEFMENIFDILCSSLSEPTVKQVFMQGEGIELMCLMLKEKRLSKTRAIKTLDHALQGFAGMELCVEFVEVLGLKVLFTTFMGKGASKKASGQLTHESTEHLLSILSSLLTSLASDSPQRLRLLSKFVEADYEKLDRLIELREETEARVNAGDGDDEFGELDEDELYLEKLERGLFSLQLVDYILAWMTMEDDGAREHILMMLARRNKSFDDIICVLSEYRDNIGEGAAKTEEKEGSEIDEAEEQREILKNLIEYLKSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PD82</accession>
    <name>A0A2X0PD82_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C029g10644 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C029g10644</name>
        <name evidence="2" type="ORF">BQ5605_C029G10644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ15120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PD82"/>
    <dbReference type="STRING" id="796604.A0A2X0PD82"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ15120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="61" mass="6876" checksum="2EC2EA5352CA138D" modified="2018-09-12" version="1">MLSSIPKISFTRTLYQATRSSPLSRSLRTSSSLMSSSHHEPGPIEASIHEKVRSLRFTHHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PDP8</accession>
    <name>A0A2X0PDP8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C020g09120 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C020g09120</name>
        <name evidence="6" type="ORF">BQ5605_C020G09120</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000082">
        <property type="protein sequence ID" value="SGZ17421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PDP8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="461"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="496"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="556"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="159"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGZ17421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="585" mass="62024" checksum="1DF6E6D8FB1A6639" modified="2018-09-12" version="1">MVSCTCTPAIGPSPSSSAGSTSSTSTTFSDSHASESTTVAGHRPVAEKRARDGGGTDHGNGPDISSLEPVRSLEIPPTEGMLAQLSKPLRRHRQQRQRRREAPCGEARAKSEAAAAPSDTRPGIKAVGPCESLDDCEKAVSKDEEPQVVEWTYPDGGLRAWSVVFGCWVFASSHLAFGMTWGVLVEDLSRNHYPNLSLATLNGVMGVAAFLMNAFAFISGRLGDKFGYRPIIAIGSILYIIALVSSALSVDRLPLLFLFLGVGVGISVGCTFPLVCALPSQWFLKRRGFASGIAVSGTGLGGAMASLIMRSLLPKLGFKKMLLVYAGINAFTTASAFTLLRTREPPRLPGQPRVTKNWLPKGVWRDGTFYSFIACVFVGIFGYLVPYAFLVTYTVKVVPNLGTGLKPAAPLIVANAASGIGRICAGLVADRAGPVNMLFASWFFGGLLQVLFWPRATSFDAIIAFSALYGFTGAWFVSLLPMAAAQLFGMEGLSTIVGFMILVNAPGQLGGGPIGGLVLTAAGGDYKVRTPRIMWGILHGLADLVLWPTYILQPVAYFGGGTMMLGSILLLYGESVPGRVPRNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PE90</accession>
    <name>A0A2X0PE90_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Arginase</fullName>
            <ecNumber evidence="2 11">3.5.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C021g09361</name>
        <name evidence="12" type="ORF">BQ5605_C021G09361</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>L-arginine + H2O = urea + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:20569"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="EC" id="3.5.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="11">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.1" evidence="2 11"/>
    <dbReference type="EMBL" id="FQNC01000083">
        <property type="protein sequence ID" value="SGZ21381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PE90"/>
    <dbReference type="STRING" id="796604.A0A2X0PE90"/>
    <dbReference type="UniPathway" id="UPA00158">
        <property type="reaction ID" value="UER00270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004053">
        <property type="term" value="F:arginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006525">
        <property type="term" value="P:arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09989">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000012">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014033">
        <property type="entry name" value="Arginase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01229">
        <property type="entry name" value="rocF_arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782:SF3">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0056">Arginine metabolism</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGZ21381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="365" mass="39488" checksum="668EBEF5F1762323" modified="2018-09-12" version="1">MSTHNFLKSPLTAGIVGCPFSGGQPKEGVDTGPRQLIEAGLLDDIKTLGYHVEFEGADSLATSLTSDQPDPDIGILKKPRLVSKVGVENSCRKMRSLSDQLINDELHFQVTQELADKVFAHASKGHLTVTLGGDHSLAMGTVSGTFRAYPEAALIWIDAHADINTPLTTPSGNLHGCPVSFLMGLPGTSPQEIPEFGWCKPVLKPSRIVYIGLRDIDSGERKILKENNIKCFSMFHVDKYGIGKVVDMALEHVGRDRPLHLSFDVDAMDPEVAPSTGTAVRGGLTFREGHYICEGQFYPATRDLRDTRFTDLHTRGLPSALAETGNLVSLDLMEVNPSLGDDLSVAQTISVGRSLVRCALGETLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PFM6</accession>
    <name>A0A2X0PFM6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C009g05579 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C009g05579</name>
        <name evidence="3" type="ORF">BQ5605_C009G05579</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY82579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PFM6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="2">
        <location>
            <begin position="229"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY82579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="374" mass="41535" checksum="81C6E0A5CFE034FD" modified="2018-09-12" version="1">MVKSKSLSAKNIWEKLKQHHEGNADPSKIRTLLYEISNASYDEDTNLGEFLQGITDKVDQLEDLGQKFKDEAIVAFMLQALPPSYEMLKQAIKLSDKCSVDYAVNRLTDEYSERKLTGKYDKLLKNAGALAVREGTQVKRDPNCICRGCKGTGHYQIDPECPKYDPNAKRGRNKNHSNKKKKQHKHSKGSADSEESASFALVVKSLEESHSLHINVANRVSQNDQSEIWILDTGASQHYVGNASLLTDRQHGSLNVQTASGQVVHCDTYGTVRFKLRSGASLSLSNVYHLPGAPVNLVSTRALYRSGASCGWEDGRDVMTIKIKGLTVAKTLNGTGYTLDFTRIVEDQAHVATRATVGAPLMEWHRRYGHIAMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PG19</accession>
    <name>A0A2X0PG19_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C009g05759 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C009g05759</name>
        <name evidence="2" type="ORF">BQ5605_C009G05759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY85479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PG19"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="877"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="936"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="996"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1118"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="237"/>
        </location>
    </feature>
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        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
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        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
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        <location>
            <begin position="321"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="359"/>
        </location>
    </feature>
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        <location>
            <begin position="616"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="880"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="936"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="950"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="998"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1029"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1136"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1176"/>
            <end position="1186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY85479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1199" mass="128602" checksum="58AD82DF46EFDBD7" modified="2018-09-12" version="1">MSPSFPPGGPPPLPPLLRHARTTSSNTFASSSSSSSGTGNGSPTRRASPFIDGYCSPVESIQSSTHSSRSADPAYAHVGTSTVRLNSRRSSAASDGHPHIAATAHLPGSSPRESAQLHSPSFHRERKPFSSPSPGLSRSQSYSSAHRSPSSSGNSRQSSPLSSRRHSYRAPGSSPSLSVSSRAGRMSPSEKGSASDDLGLGLTDKLPPAGAQLPSPPASLNGAITSPSSSRALSTIRSNEELNHTIYGHRPIASASARMFATDVSASTGRPRPDRPPRSEARSAPPTPTVPTTPDKRLPMSSSIPLIQTSSPSVAGTPSRSSDHSRSSDHSHEQRHRLERLNLIGPSSVRTDEPRRDAVDTASSIEPYLDALEASRSPSPSPLPSPNFPRLSDASAINTLQLTRQALSSQEVAVPELQTRTPKGRGASLPFMNRSVLDDGLESGKVSSSKPWRSSERQIRNQRILDNINSSSPHSGNEAAEVHGRTTHVRSSYSIDGEQWELTRDGPPRRSSWVGSERTRAASVQGAHSRESSETTSPSAIASPVFHPRSEYSPSEAKNAHTVGGSVSNSTRRGIPQEFLQAEDDNHTLHDQLPANASSTSAFIGSSPHGAGSFFRSPSSQSDNRIPTKMSGRTHPDDGSGSHPRLDLRLEHGGDSEVEDGRGRPASADYNRASRRSGIDGKSFRMKERALPLEERRRRLRDLEVGSTEWISEFQAIRALQAARTRTKTGSEDEATRIGKQASLADLESQPVSQAHEDFSSTGLRGWLPIRSLRKRDPRRSMSRLSLVTSGNIGAGAAGSSTASRNLQAGRPIAVGDHHMLVHAAYDKLHQLLDGIGNAPNSSSDASDASDLLKRTAATVRVTVKLNDGLHDLVQATANLERRTDSDEQRRRSMDSMDDMAESSILATAARSLLRTSNDQIRCLTEEIIALTRFERERHSASQDEGRSPRSLSRASGFRPSTSLGIMSPARSGDHFSLGALTNATPKLRNSASRNAFSPLSLHSPSPGSRDQYRSPLSISQDGRALSRASLSTSHPANGGSQYDDTFPESSPTTAGSQSRRRNLLSNTGATSVRPGTPSSIRRSLSRASILSVPFFDTTTNASTFESPTSRMRLRRASEVSFPSDTSMEAQRESGGDQSSTRNSFESSGTYRATPEFTSGWREGHVGGSRGVSESPEEKRETRRQEVEAILRRAAGSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PGA6</accession>
    <name>A0A2X0PGA6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C132g13379 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C132g13379</name>
        <name evidence="2" type="ORF">BQ5605_C132G13379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000056">
        <property type="protein sequence ID" value="SGY89052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PGA6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY89052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="474" mass="53381" checksum="9A29AA6AD3448832" modified="2018-09-12" version="1">MSPVAARVWDVLLGGSDAIWQGLARAAIVRTHPAPDFDLATDAWPCDYTPIRTDLHPRWQAVLKVPSTHNAQVKPRTLTLANLLALPIKLHTLHYLPGAPAVSRSPYDADYAAFSNYAKVADLFRRELYPGGGFHLWTPPTDVVVSNSEYDQRGRPQREHIVAWYRHAINRLRFTPIAQPVAAVRINGPPRVRPRSEVRPTTPLESILPHPIDPPQRLPRPALPDQSTQYNLLSMDRPYTIRRVRRVLNAKAFTDTIGFRDSLQPDDLKGFWKGVNSKALTAREREVWFKLVRNFTPTRSLQFHQKHDDSPACLVCGAPKDDREHYFFDCVDSGNVWIAARSVLCDALGLDTIDNTHYTAVQRMFGLPKLKASLRDQEGAGRTIEIFTGLVLEMISSGRWGMQKWGTRMEGVEEEDHLGGEVEAEGGRSLGEERAVEAGSIFIFHLLQVHRCGSWTISRFGVDSVWLALFGFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PGL0</accession>
    <name>A0A2X0PGL0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C038g11661 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C038g11661</name>
        <name evidence="2" type="ORF">BQ5605_C038G11661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000061">
        <property type="protein sequence ID" value="SGY91379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PGL0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="101"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY91379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="573" mass="63042" checksum="190CC3706FBD37B4" modified="2018-09-12" version="1">MEGGSTPLTKAPLLAQEFPDDVDDALHSPSAVAYLASGAAALIETSPADPAELIAPARDPPHWRAAMATPQADEWRLAARDEFDSLLRDFSAFTPIDESLVPADAKVLGSRFVFRTKRDQHGQVKSYKGRLVARGDSQRSGIDFDETFAPVAKFTSIRALLALAAAHGYHVHQADIDKAYLHGKLDTPLYIRVPDGIYMPGKVLQLHRSLYGLRQAGRIWNDKIDSALSALGYVATESDHCVYVRTTGDVHHYIALYVDDLLMISPSLPEIERTLQGLEQRYGVKWLGEAEYVLGIQIRRSPDGSISLSQEQYLKDVLARFGMSDAHPVATPMQPNLRLEVELQPTPFPDRTRYLQAIGSLMYASTGTRPDLAYTVGYLARFSHSPSAAAWGAVKHAFRYLAGTLSHGLRYARGNPAPLLGYSDCNWGACVLSSKSTMGYTFVYAGAAVSWSSRLQSRVADSTCDAEYLALSHAGKEAIFLRQLFGELGLSSSKPVLIYGDNQGANALTKNPVFHARTRHIRLREHFVRDMVSMGDIVVQYINTGEMTADIFTKALSRDLFARHRGRLGICAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LNI3</accession>
    <name>A0A2X0LNI3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C011g06243 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C011g06243</name>
        <name evidence="1" type="ORF">BQ5605_C011G06243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY11709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LNI3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY11709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="56" mass="6387" checksum="84DF2A56C853A5AB" modified="2018-09-12" version="1">MWFRHPPCQSLLTQTSLPLRCKQPPYPLLCKVVSHPLLRARANFSRLALSRLAVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LRH4</accession>
    <name>A0A2X0LRH4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BQ5605_C013g07332 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C013g07332</name>
        <name evidence="11" type="ORF">BQ5605_C013G07332</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Essential for the assembly of ubiquinol-cytochrome c reductase. It has a direct effect on the correct occurrence of the Rieske protein, core 4, core 5 and apocytochrome b.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CBP4 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LRH4"/>
    <dbReference type="STRING" id="796604.A0A2X0LRH4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012420">
        <property type="entry name" value="Cbp4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07960">
        <property type="entry name" value="CBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY15336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="87" mass="9416" checksum="EE871980448622EB" modified="2018-09-12" version="1">MAGRIPVGKAILMTGLVTALGYGIMALTTPTDEQFYNSLSPDLKKKVDDARRKGGVAQANEEHLKSIQASAQDDKPVWATTDVKTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LRU8</accession>
    <name>A0A2X0LRU8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C013g07355 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C013g07355</name>
        <name evidence="2" type="ORF">BQ5605_C013G07355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LRU8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY15386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="62" mass="6553" checksum="152083046350F5BF" modified="2018-09-12" version="1">MPESTSHAAAAEKASQNAGQPSSHSHHGEEKKAGEKPEHEVGARSGKPITTQVRHFSGRLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LSH3</accession>
    <name>A0A2X0LSH3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C011g06461 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C011g06461</name>
        <name evidence="3" type="ORF">BQ5605_C011G06461</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0LSH3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635:SF196">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="951"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="410"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY12309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1623" mass="178295" checksum="F473DCAA86B5135A" modified="2018-09-12" version="1">MDNNNNTNNASHAAIPPLRPDPPDPPGQAPATTTKSYSAAVGARSAAKHGNATANASTAVAAHPLMHNIENCVIINTPPSTSVEQVLLALDKYYPGLTGAMPCVIKGQRGLRFPKAADLDTLVANGLTVGKNLCKVEKLYSSTRGGVVQCTLTGFFSDPEGLCLFDEQIAAYGTVLRCRIQYIGKTKHISGVYDFILALKDVDVLPPASLSIARDGVTERIPLRITGGMRHCVFCRSAAHVRKDCPVAPACKSCASTSHATQHCPARHGSSPQGPPTSRAPQASTVTTAAPAAVSKSISPTSAHDRTTKKRRVEQDLAAQTEDLSNRAQPDSLSKNARPEFSFNFPCKTATPPAPQPASNQGIAYSLVEKSSKSPSSETTSPSPSPPPATPKSIITRSKLIAALSKPATREAPPTAPALEASEPSPEPSSPTPLPSAAPKARPDDADTDDEADEEAEDQEAPPKDSINEDRKRASLFSNLRSHNADVFLLSKTGQPSPERVAQWTQECQDLKLSALFTPFNNTAILWKSDSVVITFDPESPPNTLRASFSFPDRVTDATFCVGDSKVRVVSIYAPSSNKPDKKCFLSHLSTALRQVVRDEPSPPALLVGGDWNCVESQPLDSENQNGTNYGGQEMRDLDTANNLFDAYRLHHPKGRAMTNRSAPGTCRRLDCIYVSPDWVDLFHDHKIWAPVLKSTHSMVVARFQVPGAIDIGPGKFKLGLHVIEGDATCEYLTSIVRTLYNKALLQTPNDPPAAWTSTKHRLLPELQALARTFARFRRGGSEQERADHSRYGAALRSRLDPSLAGPSSIFIRLRKVQASDLIPSLTVNDVVHSDPDSMLGAASDYFERVYEDRPIDDAALKAIIDGLTSTRLSPADSLKLEEAYPLEEMTKAQAACKSNSLPGPDGLPVEFYRATWPATGPILRDVINSIPTKARQPGPLPRNTAHIHLIHKRGERDQLSNKRPISLINADKRIISQAHNQRLAPLLESLIGPTQRGFVPNRWIGTNIAEVQCLMDPGLPGSTPVSGMLAVMDFEKAYDRLSHPYLDAVLCAVGLGPKARQWYRATYTNQSASIFLNGWLSATFDILLGVRQGDPLAPSLFVLAIEGFACQIRLRVKGIDIAGLQNVRELLFADDACCALHNLSDLDHLNRAIELYERASASKLSNVKSFLYPLGAFRDRSIAPDLGTWRLSDSQFRYLGIQVGVEIAEDAGWEDVKASTIARIHSIPMYDLPYAAKCSIINIYCYTKILYYSRFLPAPKSVVKEIEEAAMLAIHGRASDGTQQRPKVSRSRLCTPLDHGGFGLIDLPRRLAINHAKWVFQLRAPDGCFTRHLFDIRIRLQAPNKPTPFTLSRPAPNQHHCPWIWIWWAYFCHPPPKWDHAVRKTTKLLPARWVRYFEAWALVTTLNPPELSKSQNLEQWATHVLYFPAGHGIQLSVNPTLFRGPNGEVMTPSSFVNASKRHQVFIFPPIFPKGHQKVFDLPEQRWNAWWKALRKVRRVHSDAKDTGHLLSLGSLHPGSQVASPTSPHPNNRSTSCVMCLSEAPECLVHLAVGCPFARRLWSALSPTPHPVFVDFLCRRRRFSSDFVKGLGYYTDLLEPITETEFEGLRASIQESKGRLVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LSJ2</accession>
    <name>A0A2X0LSJ2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">BQ5605_C011g06481 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BQ5605_C011g06481</name>
        <name evidence="16" type="ORF">BQ5605_C011G06481</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LSJ2"/>
    <dbReference type="STRING" id="796604.A0A2X0LSJ2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0229">DNA integration</keyword>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Retroviral polymerase SH3-like" evidence="15">
        <location>
            <begin position="55"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="14">
        <location>
            <begin position="290"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF25597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SGY12361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="574" mass="63998" checksum="7A43F4D90B8B128F" modified="2018-09-12" version="1">MLKDSGLPKKYWFHALEAATFVSNRGPHPHLKGKTAFEVFFGKQPDVLPLRAFGSIAYVLVPKAILKKLDDHTVKGTFLGYSGEYNYKVCIKHGRSFKIVVSSDVTFSNKAPLIADSAVEPRIYEVEPLQEHELVHQLPFPGLEQIPALRPALVPEAEVPALRPALFPEAETVEAIDSDNDDGPAEHNQPLPPENGYEYRPYRVSRNPGALKNVNAGNILPTCLRAQHRTGALCVVSTRTVYCRPPELIAMVSSRHPPLPKTFVEVMVSPEAKHWMAASEKELGSFKLHKVFKLTRLRTGARALGYRWVFTRKEYAEGNIISYKARLVIQGFAQRLGIDYNEMFAPVSLITMILFLIAISAALGLVLEQFDYDSAFLNGIMEEDVYMKIPEGWTGGSQPGHALKLLKSLYGTKQAPRQWNAALHKLMTDCGYTCSNVDACLYFKYHGKSFAIITLYIDDGLAASNNQAFLDSEISAFDAVYKLKRLGPVKTFLGLEFIRTKDFIFVHQSKYIRGLLEHCTFENKSKKPVATPMEDCVVLSSTAPFANILVYQSAVGALQLVTGILIITHSTLWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LTA3</accession>
    <name>A0A2X0LTA3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BQ5605_C011g06350 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C011g06350</name>
        <name evidence="12" type="ORF">BQ5605_C011G06350</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY11994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LTA3"/>
    <dbReference type="STRING" id="796604.A0A2X0LTA3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF149">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="424"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="603"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="640"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="666"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="10">
        <location>
            <begin position="27"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="11">
        <location>
            <begin position="201"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="377"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="807"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="843"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="900"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="993"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="926"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="956"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1016"/>
            <end position="1044"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY11994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1078" mass="120833" checksum="46E72EA3DAAEC972" modified="2018-09-12" version="1">MSSAAQQINQIANEYNSKLNKVAPKAVGIQLALMAALGLTAIVSFSILRPNNSVVYQPKVKYSEDEKRPPKLGKGLTSWVGPTFRTDEQQLLTTIGLDAVTYLRFLKMCRNALLVTAALTCAVLIPLDVIYNLRNVTSKNRNSLLILTISKVRGSWLWAHVTMTYVLTAVVFYFIWVNYDQMVKMRWQWFRSDEYQNTLHARSIMVTQIQKRDRSDEGLFNLLRTLQIPYPTTAVHIGRKVGTLPELIQRHNDAVRALEGVLTSYFKDPNRVATNRPTMRVGGWMGMGSKKVDSIDYLTQKIQRFDERIEVTRQGITGAKPENYGFASFETVPYAHLVAKKLEGKKKGDARWDLAPSPQDIIWDNLTMHDNSRRKNKFFGAILLLVFCIFYLIPLAAASLLANLSSLIAYVKFIRDWQNNYPTLFAAFVGVVPSLLTALLQLLLPVVIRAIASMQGAITHSRADRVVTARYSAFVIISQFVIFTLLGVVVQVAMKLYVEIDAHSSASEIWNYLKTVPDTLQNTYIIQSSYWLTVFPLRGASALFDLAQLIALLYVWIRTRLFGRTPREIREWTKPPEFDYPVYYSNHLLMVAVALVYAPIAPLVPLFGCFAFTVSYWVYKYQLMYVNTTRVETGGRLWNVCINRVLVCVVLMHALMAVTMGLTSNWYHSISIAPPFIGVFVFKFFLDRQFSDRFRWYVPSQTELAELRTHHADARKNRLERRFGHPSMFDPLFTPMLHRKIEHLLPTIYHGRIDQTRGTLEGKKVEQNKIGGLTFDLLEESQLAFDRNAYLHQRDEDAMTISSATQLHASPGTGPGMGPGSAGRYVDGGDYFNTRREQYLQHGASKNGSPLGTPIDDMDVPNELSRMPTGGTMGPSSSTDQLIQYPPSYAVNSFGSQPGGSISRYAGHHPTSSVGSTAKYPSVAPSDREEEHLHEQQQQQRRMSAMDFGVPLPSSPHANYSAVSRSRTPSPGPDQAYRAARDPRASFEAAFGNSLPSRHAGSEQPPMHHIRQGSLPPGPSPRSLPMGATPPRPIGAATPPPFIPHAPMANSASPFAAFGPRPTGNGSPRGYEEPFDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LUQ6</accession>
    <name>A0A2X0LUQ6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C017g08437 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C017g08437</name>
        <name evidence="6" type="ORF">BQ5605_C017G08437</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY20023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LUQ6"/>
    <dbReference type="STRING" id="796604.A0A2X0LUQ6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000024">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="106"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY20023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="649" mass="71374" checksum="EB82295119164BFC" modified="2018-09-12" version="1">MTLGQRLDYYLSQVPPAPTALHHQWTSWRGDRSDWTMLASILVPALAGWVYLKLIHVPWDERASKFEWLVPAEALPSWKPAKVLSPASIDSHQSDPSLIPTTEHKSQERTYITCYAPASGAHLSTVPSTTAAEIDEAILKAENAQREWRTSSWSRRRRLMRTLLRWCTVEMEGIARVASRDTGKTFVDAAFGEILTTCEKLRWVIANGEDCLRPEPRPTNVVLAHKVSKVHYEPLGVVAAIVSWNYPAHNALSPIIASLFTGNAIVVKPSELVAWSSHHFVQAVRSCLSACGEDPNLVQIVVPLPDTVEHLTAHPRIKHITFIGSEQIGQKVAIKGAEAGTPVLLELGGKDPCIILDSADLKAFENTWMRAAFQAAGQNCIGAERFIVHEKVYDRFVASMASRVEALKVGDVLAKDLDRDPTNRIDVGAMVSDRLFGELERLVLSAVKDGARCIVGGKRIKQHPTSPQGHYFQPTLLVDVTTEMEIANQEVFAPVMTVMRFKELDEAIELANSTRYGLGASVFGRKQSDCRYVVERVEAGMVCTNVSYVDCKTDFGVFYLNQALPFGGCKASGYGRLAGKEGLRGLCHPKAVTEDRFHGWIQTGIPPLLAYPINSGLGAWGFVSGLVGMVYADGVWNKLKGLVGLVSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LVL8</accession>
    <name>A0A2X0LVL8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C016g08148 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C016g08148</name>
        <name evidence="7" type="ORF">BQ5605_C016G08148</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY20812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LVL8"/>
    <dbReference type="STRING" id="796604.A0A2X0LVL8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="6">
        <location>
            <begin position="10"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="126"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY20812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="336" mass="37167" checksum="6ED474560BADEAF6" modified="2018-09-12" version="1">MSPRSISTRRPPDFVKKLYFALEAAQQTHEPDLRWVSPGEFEITGDQKRALEVLQRYQLDFKLFSSFVRQLSYYNFKRLSDRRRSDARGKPGVKENIHFGHPARDFWTGNAGKAFAVMIRKSRKRKDRASVTSNCSTSYSDSADDGALSPTHSGDSGRRGSVASIDSHGRHSMSSDYVTPQTSLAAFPSNAQKPSFINLNASVHEQAVSTLPVYPSPLSPSAVTPYWTHEHSPLAQGSPYATMPAGSDRMPPGENVFSYTFGAATRGMTAPMSSYYYPNEGKHASSSNLQAGAYYPSQHERYMAVDAARWGQVDSQPSLSSAALPTPPDYYLPPYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LWB2</accession>
    <name>A0A2X0LWB2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C019g08970 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C019g08970</name>
        <name evidence="4" type="ORF">BQ5605_C019G08970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY23700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LWB2"/>
    <dbReference type="STRING" id="796604.A0A2X0LWB2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051938">
        <property type="entry name" value="Apopto_cytoskel_mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44145">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44145:SF3">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="55"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="179"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="230"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="247"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY23700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="316" mass="34612" checksum="A1EC9E168FC77583" modified="2018-09-12" version="1">MRPRTPLLTSLLPIPNLSRHLSILASGTTPACATTSRHRCRPFSSSTRSLANEQDHYANLGVLRSASRNEIKDKFYQLSRKYHPDAPSVSSESVESRTARFQTLSQSYTVLSDDTSRRQYDATLGGSPSSSFGSRPRYTSGAAHEVGRSGFGGGSGAAWSWTSAENEARRERANYAWSHLTRTSKNPRNDEQYQEYTQAGSGSAGSPFHPNRDTRTSDEHFQTFAAREARMRGRGRGPAPMSAKAGFNSSGSSRFSTGTASFGAKADEENRLINDSSTKRTGQVALVFLTTFMIAVSFSGNNRVSSTIPTNDKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LY97</accession>
    <name>A0A2X0LY97_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C014g07694 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C014g07694</name>
        <name evidence="6" type="ORF">BQ5605_C014G07694</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY19595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LY97"/>
    <dbReference type="STRING" id="796604.A0A2X0LY97"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00625">
        <property type="entry name" value="RCC1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="154"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="5">
        <location>
            <begin position="155"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="220"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="281"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="339"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="420"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="611"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY19595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="686" mass="74271" checksum="4AA9306763B061E9" modified="2018-09-12" version="1">MPPRRRNSVSSVGAAAAPNGTTPATPRRTGRASSTIPVDLTTVSSTKPTSRAGVAAKRVSSTSAKRARSRSISVALSVAEQSEQEQEQEEEDDDVDATPRAKKIKVFIEPKIKPVRAPVQGMNQIPKRYDPFPAYSVFDFEVNIQEVQQLDLPKTVFVFGNGDFGQHGLGIENGMMEIVRPRLHATIEKMIAGEGGEAWKRGVASLECGGMHTLCVDGEGKIWSWGINDNAALGRVTAGLEQESEELETQPLPVENLDYSRFKAVKVAAGDSVSLAVSENGELRCWGSFRYSEGILGFDGNDEKSKSQLKPLALKNLEAVSIVQVVTGDDHFVALTTKGTVFACGNGEQCQLGRKIIQRGFRVPKIASDDYNCSILNHVSFCVGLTGHKTHGLTPERLALKNIVVVGSGSYHSFAVDAKGQVFAWGLNSFRQTGVDEDDGGWQEIITTPTIVKSLHPSLHRGARVVQIVGGTHHTLFLFSNGEVWGCGRCDGSEIGLGKDHPKMKEMKEREDEALKRRKEFENSVRPKIAQRPVADDDAGNPGRPMTEMEINLKAQEEAAQTVPLPNRFIDEPTKIEFDTDAQEEENIDGPVQIVQIAVGTRANFAVSRHGFLYAWGYGNVAQLGLGDEEEADRPTRVVSRAMKRFKVLHAAGGGQHSVCVAVRGDGAKPSIHDDAPAVAPAAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LYK0</accession>
    <name>A0A2X0LYK0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C017g08386 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C017g08386</name>
        <name evidence="2" type="ORF">BQ5605_C017G08386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY19922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LYK0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY19922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="125" mass="13844" checksum="857D19C3C5D0EC17" modified="2018-09-12" version="1">MRSTWCGPFVRESEDRARSPPPVPGGTIPSLSRPQRRPSDSRCHGRLVPRRPRDIFQSAHCQPPLPHGAPVCLGRTLDPRACHPRDKRPQEVRQRPGTSCVQEEPNATTIGQADLHALGCTRTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZS9</accession>
    <name>A0A2X0LZS9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C016g08062 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C016g08062</name>
        <name evidence="2" type="ORF">BQ5605_C016G08062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY20462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LZS9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046921">
        <property type="term" value="F:alpha-(1-&gt;6)-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13132">
        <property type="entry name" value="ALPHA- 1,6 -FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13132:SF29">
        <property type="entry name" value="ALPHA-(1,6)-FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="743"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="765"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY20462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="801" mass="88271" checksum="4DD8E1AA38C4A84E" modified="2018-09-12" version="1">MRPSHLRNRSKDSMSKHWDLQKDSTTIHLGEHHPAGVDDTPSTFRHVRLFNMASSPPSSLSPPRGARSPAWAFTTPSPWLGKDASAVVNMLHRRSASMAIASKSTSRRAKTWLALAVVVGLCIWSRSFDAPAIFGTFSSPAPEAVFEASSPLSATVASPPPMVSVEERPTPSYVPVEEELPSVDQALRAEASIFPKLPPQDQQAPSPPSSHASPPTDEIIDESNDESADTDTYTDTDTSDETPPTPSEQLEQDLPAIEDSIKLVDHPAVTVSQATPWVLEESTERLPRCRKILLFQFTPWWGFASEWLLYLRAASLADELGYTLVEDDRAWNYGRLSNYFSPRKLNCAPPRDWADAQLATGIGLPGWKKEPRLVWSRLRIQQMDDWTRETYLDPVVMQKLHDTNVAFARNRSRNILAEGDTMPQGLEEVFKDHVKAARFLWKPIDSINTEIEAARTELKMGPQQITVATHIRLGDKGPEYELEAKAMGITNKFGNLTVYLQAAHDAMVRILPGGTPYTEEVPSPNGLNLDSARSPSLVVMTAEANVISRLAIDPLLRPFTLAQPPARGIASLKHVANPKPQPSQPPVDVMEWVKDTQADALTTYEKRASIREDEEEAAPSTPTPSPTPTPKEEKKKPRPGLASGFSQLEFNRLPMLERVLHTRTFIRDLTLFSRDADAFIVSGSSNIGRLAMLIGGYEATIGPKDEKGRSLGGRIRSIDAHWFPTAYSEALYHTVMDQPQTAAVPAFPLSDRRKGKGRLAKDKSSSSMTNRSSPSAMPKGSSLSSMRKGSLPPSTPEDGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZY7</accession>
    <name>A0A2X0LZY7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C003g01858 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C003g01858</name>
        <name evidence="8" type="ORF">BQ5605_C003G01858</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY37678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LZY7"/>
    <dbReference type="STRING" id="796604.A0A2X0LZY7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="7">
        <location>
            <begin position="533"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="507"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="648"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="177"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="524"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY37678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="713" mass="78133" checksum="6DB42CC3FC0EFFFF" modified="2018-09-12" version="1">MDGREANTVTRSLNRSGDEMMGRQPPQTMMLMGQKQEKNTPWHVMLPSNPSTPPSGFDHRRPNWVDEHGPTSCASADASAVPQSAPTAAHAPPPPPPPSAGSSGVTGAAPAPGHATAAGWPPGSTEQARDGSGDTDSYQRHQHHQQQQQQHHDQHRPLQMVPLSAHDERHALPSRAYSQQHPSHQPYQQPQYLQQQQQPQHQQQHYSPALHHHQSMPNFRTSPMHPGSPASSTGGSTPRARPGPMADRGTPSTHSSHVYRPYNPLELLPPHASQPRMSHPNFESAHLASAIGSDDRFPTAGPARVATVGASLQQPSSGASSHPDEPTIQTLQQSAILSASRNSSMQKHDIHGIYQHSYPLSHLQQQQHDTSAVGFSHHVPPTLAMSARSGESPTSRQQQFYPATAQLVHYARPSSSSSSSVTSSWSTLSPILDRPYQPNAITSGPTAVYSPSVNQHWGPSSANEFANAGGVFSAAPRYSTYEEGIMAQSGAQYLPIASGMSVPLLSSPPIPLRPRHSPPGERSTGSDEERKESTTPFISKLSHLLSNEDYRHLIRWNDEGDKFTFAHSSPELLEAFTRIFRHGNIHSFVRQLNICKRPYYSFTRLSTMELVECLPSNEDPARVSDYNGFMHPLFFRDSPHRTCDLTKIKPKASKKSAASKGNGNAMFANAPPTPGDKRRSSLSGLSSSVRETTSPYAFHPHQPQLQDEQYHRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M060</accession>
    <name>A0A2X0M060_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphatidate phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C003g01885</name>
        <name evidence="8" type="ORF">BQ5605_C003G01885</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the lipin family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.4" evidence="3"/>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY37768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M060"/>
    <dbReference type="STRING" id="796604.A0A2X0M060"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000063">
        <property type="entry name" value="Nuclear elongation and deformation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026058">
        <property type="entry name" value="LIPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031703">
        <property type="entry name" value="Lipin_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007651">
        <property type="entry name" value="Lipin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013209">
        <property type="entry name" value="LNS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031315">
        <property type="entry name" value="LNS2/PITP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181">
        <property type="entry name" value="LIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181:SF12">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16876">
        <property type="entry name" value="Lipin_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04571">
        <property type="entry name" value="Lipin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08235">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00775">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LNS2/PITP" evidence="7">
        <location>
            <begin position="817"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="131"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="311"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="383"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="451"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="500"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="671"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1048"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="221"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="263"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="329"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="422"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="465"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="713"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="723"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1050"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1064"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1125"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1149"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1165"/>
            <end position="1194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY37768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1202" mass="130988" checksum="6D849707E3A3E5E0" modified="2018-09-12" version="1">MQWVAKVSLESIVDRSVLSAWVVMGRGAVQYYKDINPATLTGAIDVIVVERPSEDGAGTELACSPFHVRFGKLSVLRPIDKKVRITVNDQEIPFYMKVGETGEAFFVFETDADVPENLQTSPIAAPIQDDQLQEGDHAPGEPEYLDLNAPEGEETQPGTYLSSPTSSVYASMTQTQVNSPTMTLEPLPPVSPSLQTASKRDYNASSPARPGPSRFAKDMNGEEEEEQEQEEEGVDNDDEAEAEEADEADLAADAKAKPKKKERFTDSDHHETAKAKSASYVPAAVHYAVEKVVGIGGIALAGVAGGKKLTDAVKNDGRSSVQGLSRGQTPRDLEGGLRGENESGQSTALEKEMKHNLEGANVIAESEPGDDVVDAARRHDRDVRELLGGRSGTGRARSVLGKTTQEYSLKKSETGEVEVDVDGLKDHSGTRPHPERAGDLMLDMSGYKLDDASTINASDSVAEGETSDGEPREDDINALDEKAQEEMVAFTQSLLQSTDPKTLRNFFDPSDDQSSRAASPEPFDDNETIAPSSPDFKARHIRTYSRASSPVPSSSMSISSLQTLAAESADSDAASLTQASPRQFTLKVGSKVHVFELSLCGTEAFGQDRAADERGFAEHQVTFTQFMEHDSVADHSDLVVKYGGRYLTWSNASPVLASLAVYRKSLVDHPEHHPNLESGAKSGRRGWSSWWRGSRDRSTTSLPVKEPLDGAPTSPPISPPDSPRSLPARLDSSTPSSPALSASGDDATSAPGPVTGPEGGNNGGKHYAKTLRLTSEQLKELGLKKGMNEISFSVRSSYSGYATCSSRIFLWDSDHSVVISDIDGTITKSDALGHVFTMIGRDWTHLGVAKLYTDIARNGYKMMYLTSRAIGQADTTREYLKGIAQNNFKLPDGPVIMSPDRLMTSLHREVVLRKPEVFKMACLRDIQRLFHERSPFYAGFGNRITDALSYRSVDVPSSRIFTIDSNGEVKMELLELAGYKSSYIHMTDLVDQMFPPINRKTQPDFTDFNYWRAPMATIDLPDLSPPSPALSARSGDSSRLAFPRLGSIASSLSRRSPRPTLTTDGATTPDGTNRSVRSVTPSSPLLPATLIEEPFNLNGEYDGDEDDGQRSESESMPGSLPNDGDFERLRREALRLAEQKNGTRTPAEAYKEKVKGSSRGAERVDGDEEEEEEEEEEEEDDDDEGEQGDFDDQLDFSSVPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M167</accession>
    <name>A0A2X0M167_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g02298 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g02298</name>
        <name evidence="2" type="ORF">BQ5605_C003G02298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M167"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY39940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="551" mass="59046" checksum="64C228CD9F3EF2D5" modified="2018-09-12" version="1">MASLGGIRDLYERAKTVTTHRRSDSPAPFWSPLDSAVPEGFRISSSTFTVSVSPFSTLSFTSCGRHAKGTLLYMHEGSLTTVETVMSGQLPDYDERYDQTGAAVTSSDSKEASHVKVVVEARHNSDELLRLCKIGTVQKDLEGGIYIETPEESARGTLAGASISFHITFELSVAVKALDTLRVTSNQFRILFDPSLSNLAIANLELSTSDGPIRLDLVRVGRAKIVNLNRLDPRKSSLTNHNDLVSGRIVASDDLVLDCSNGPISGTYTTTYPNAPLAIKTVNFDIRDVAVRSAGGIYVSNTNASITGYFFAKELLTIETQHGKVGDANSTFRGERGVRITTAAAGINGRFEVAKELTIKSSSMPIDAHVTILSRSAISEQASVLAAANIVDRDRPGLLAAKDAGRSSFEPPSFETAVRNGAGQSTSRGLETLTVLCETKDSHVMLDFQNHPREIKLTSEVKTTGGGLVKVTHPKEFVGSFSVATGALQQAVLDVKPDADSDSVVANKKAVSYKIKKRAEIIGTITYEDDSVKPRNSTKIVTSGSAELVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M4M5</accession>
    <name>A0A2X0M4M5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">BQ5605_C003g01992 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">BQ5605_C003g01992</name>
        <name evidence="17" type="ORF">BQ5605_C003G01992</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY38285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M4M5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="16">
        <location>
            <begin position="158"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="SGY38285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="863" mass="96997" checksum="353C46903534C3C6" modified="2018-09-12" version="1">MKEIFDLTGLSSSKPVPIYGDNQGANALTKNPVFHARTRHIRLREHFVRDMVSMGDIVVQYINTAGPPLVSLLLKQLLGLVSLGPSIRDLPPLEQCLSRCVTSNFLVWSPLVLRSETYHRLSRCVTSNFLVWSPLVLRSETYHRLSRRDNITSAKGHHLPFPNSDSHSSERLGLVHSDVLSLPERSLTGKQYVVTFLDDYLRKLWAYTIGHKSKVFGVFKTWLAEVKLETGATLKVLRTDNGGEYRSKTFTDFCKARGTRRQYSIPRTPQQNGRAERVNRSIVEGVLALLADAHLPKTFWEEAAAYFVYCKNLCQHSALDKETPNSVWQGERANALALHPFGCTAWLTVAPELRSKLDPKVVRVLFTGYDLASKAFRFYDTTTKKIILGRNASFLDTGFPGLLGDYTEEDADTHFASAPIAKPQDTVKTWTPLPQVRLDPPDVHRPDFGTYREPASAEESPDKLDLIGRHSRDESPDEIDFLTRHHRAFIATDDDTSDAEAIQPVKSITSDPQTWREAMSSDKSEVWARAADDEFNSMRDDFKVFTIEDHSTVPTGATIVTSKFVWKTKRNALGEITGHKAQLVAQGNRQRDGIDFNETFAPVARFSSIRSLLALAAANGLDVHQADIDKAYLHGDLDHDIWMTAPRGFDLHSDKVLWLRRSIYGLKQAGRIWNRHIDASLHDLGYTATGTDHCIYSRLDDRQRSHYIALYVDDLLMISPDLAEIERVISGLERRYGVKRLGPAEYILGIQIRRLADGSIALSQERYIMDVLARFHFNTTTRGTTVPMTPGLSLTAIPGEGTEQIKSWYLQAIGSLLYISLGTRPDIAFAVSYLARFANNPGQRHWIAVKSEVVTPAQAVVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M5N0</accession>
    <name>A0A2X0M5N0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g03996 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g03996</name>
        <name evidence="2" type="ORF">BQ5605_C006G03996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY55266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M5N0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY55266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="428" mass="47437" checksum="7EE137DF91FA38B1" modified="2018-09-12" version="1">MRTRIASSVRRDEGGAPPMFSASRTPRTAIALSDITNNLVDTKPDLSAGKKKVPAGAHQRAPLNKAKPSKAAAATASDAKPVKPVKPVKLLKLEKPEKSSRVDAVAEDDNSLHASTHSSDGDLMPSPPATMKAKRTNLPDQLQQPLKKASSKRQRNDTPDDLSDCSEDNLPLTEALSIFSTALATARSDLHKLIGRVQRKEVDMLRAMQSWYKDNPTTYTDEHLAWWSVLRLVEQTDVERGFADNKREFWLHLSGFATTLAKKAAQRFYHARYCPNGAFDYSIFLYRTVVSQFYDADTSPMTTRPKVSTMDSTFQAQCTTVITTCQPVADFQRLVLDLHGVVAGAMADPYSIHIAFAWCRPFDRRGTRPASSKLARLRSTTLLHEFARGLRARKPTWAPGGHPMGAMNFTQRCVAIERASRREATNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M697</accession>
    <name>A0A2X0M697_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C003g02542 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C003g02542</name>
        <name evidence="6" type="ORF">BQ5605_C003G02542</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY41705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M697"/>
    <dbReference type="STRING" id="796604.A0A2X0M697"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004092">
        <property type="term" value="F:carnitine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF103">
        <property type="entry name" value="CARNITINE O-ACETYL-TRANSFERASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="5">
        <location>
            <begin position="90"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY41705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="711" mass="79550" checksum="C31B04A0D5D88362" modified="2018-09-12" version="1">MLVPRRIATHSTYSHFARPLNYSSSFRAFVIDNSARPSPSFLLSNGARAFHSNQPKMSPAPKWSEWRLSPPSATPLGSITFRNQAQLPRLPVPELDVTLEKLIESCRPLAKDENELEEFKRKVSVFRQGLGGKLQERLVKRRESEGMRNWIAEWWDNDAYMAYRDSVVVNVSYYYGFKKVPQAPSSVSNPPTSDPAYVAASIIITALEFRRLVIKGLLEPEPAGKEGELCMESFKWAFNANRIPAKPADYAVKVREDSKEGQHVVVVLKERFYKVPIVDQEGREFTVEEMRRGLQGLLDKVEKEGKGEGEGVGILTGLNRDTWTDAYEHLIQDAGNKQVIDEISKSAFVVAFDQHRPEPAMEKVEGKGGKNMSGEGIRDFSERLWKAGGQGKGIGEGANRWWDKPQQWVVFVNGESGFIGEHSCMDGTPTARLSDFVSKRLLTRQPVEVGSSDPAPKSSPTIEALDFHVDAQTKHAIEKGKKEFEKHVGGHEVFYLHYGRYGKEGIKRNKTSPDGWVQMAFQLAYYMTHGKPCGTYEAAQVRRFQLGRTETVRICTSAALAFAQAMTTPSTTLSEKRSLFAQAVAQHGKDMKAASSGLGIDRHLFGLKHLFLNAEEASSPSAELFQDPLLKRSSTWTMSTSQIFIEHSPAYGWGRVDPDGYGIPYMVHKEHLQFSVTCERHMKGREFIANLGKAADMIMDMMEASAADAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M6R0</accession>
    <name>A0A2X0M6R0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C001g00429 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C001g00429</name>
        <name evidence="4" type="ORF">BQ5605_C001G00429</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY46414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M6R0"/>
    <dbReference type="STRING" id="796604.A0A2X0M6R0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000038">
        <property type="entry name" value="TBC1 domain family member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000031">
        <property type="entry name" value="TBC1 domain family member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF337">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="166"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="570"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="663"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="802"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="676"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="738"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY46414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="852" mass="91772" checksum="D118BAD71A63C2D3" modified="2018-09-12" version="1">MVSSPDISAKEPAYRGDDSTNTNDHERPSAATLLSQWHSFFSDPFLSPHTLKQSSLSGKITTLRSLHWRYLFFLLPTPAPLGPSSIPSSTWTSYERMLQHARSEYSSLRSTYLRSPDGKWCSDYLSLASIESPKPPVPPKFTANGHSSVASGRMTKVQVDQNNPLAIDEGNPWTSWFEDLELRRVIRQDVSRTFPEIPYFHSSQVQDQMTDLLFIFVKSFASDTGYRQGMHELVALVLWVVDCDALPPLASRDGKSERPHDSEGLARLVLSRDHIEHDVWSLFTTLMKSAKSFYDPTPSVSLPAAASKTPSPATAAASTVMVQPIVATSMRIHDSLLATIDPELHAKLDRLGIEPQLYTIRWLRLLFTREFPVEEALLVWDGIFAEDPNLRVTEFICLAMLMRIRSALLMADYSGCLSLLLRYPRPTSSPDSHQVTYLISQALLLRDSLSPSTAQMILRVNEQYGLQAGDSGLLRLERGEDDLPRNGGPGRGVNNGALAGKGLVGDLAKGVYGRAEALGWTGALQGGLATINDLVSVGLLFRGMTAQLAARPLARDPLSRIPDRAPWEVVQQPHHQPPETTRPLPPAPSSPSLSISKSLRLSRAIDACVSALQASATDGSSHSTRDIMDVLKHVRDVLGSNGSVLVDESILGRISAITMKMPKSPLVDNNGVQRPSISSASATSTSITETSSSSALVTPPSMHPSSPGVGLASRDTSSTPSPKLGPAFVETKPASSCLAHSTVPSSPLSATPSIQRKSSPVPQPHTQKSLGLGANARAAPLPLTGFSTRASGMTFGLADRGSRTGDGIGLELMSSTSPSSPPSMGGGKRSSTLDTVRDPLGAVGVEGVWRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M7J9</accession>
    <name>A0A2X0M7J9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00457 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00457</name>
        <name evidence="2" type="ORF">BQ5605_C001G00457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY46659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M7J9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY46659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="207" mass="21537" checksum="96E1B57B4E6E2683" modified="2018-09-12" version="1">MHAMTPFAAATPPAFSPPPGASPAPFRPSPAVRASLPLPHAPSGGAPGGGTAATAPNRSHRAPSIMSTSRMSGLPSSFDEPVLEARKVVALLNGVEGQSGSGMLARLEQECQVVFEMYGRAYEEGYKPDPTALQNMLSTMQHLLSTLQSSAVGGYPLAAASSADSSSMTPSALATRIEQASSTVRDLFKERMRVKEGAEIVRNVLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M7N2</accession>
    <name>A0A2X0M7N2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C007g04650 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C007g04650</name>
        <name evidence="6" type="ORF">BQ5605_C007G04650</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY62070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M7N2"/>
    <dbReference type="STRING" id="796604.A0A2X0M7N2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052113">
        <property type="entry name" value="FYVE-type_Zinc_Finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39490">
        <property type="entry name" value="ARRESTIN DOMAIN-CONTAINING PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39490:SF8">
        <property type="entry name" value="ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE zinc finger" evidence="5">
        <location>
            <begin position="112"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="263"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY62070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="304" mass="32187" checksum="C18A9BD07E7E2CE1" modified="2018-09-12" version="1">MSTTAYTQRNQRSTLHTTTPKVDTSCQLSFAPRNTRCQPLYRPAALRRNGSQTPVSAMPVSPPVSPHALAAELSQTSIKAISPQSWLGVLPWASDVNHYKSGDSSVAAGVALPRSAWRPDEEALICAASDCSLRFDLINRRHHCRKCGEVYCSSHSSRMVSLWPPTMSPGEHDISTPPTPRATPKSTPRSSYVDLSSLAFAASSSSKSTNPSNSSAFSVAASSESSNSSSTPTSSPPNGRPFLGKPMSCRVCDSCYFNAPASVPQALLTPPPTSSTRSFMGSPKGPMSQSPPNSTNQVAVSLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M7Q1</accession>
    <name>A0A2X0M7Q1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BQ5605_C001g00548 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C001g00548</name>
        <name evidence="11" type="ORF">BQ5605_C001G00548</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY47615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M7Q1"/>
    <dbReference type="STRING" id="796604.A0A2X0M7Q1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="83"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="227"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY47615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="328" mass="35770" checksum="05499850D1354AB6" modified="2018-09-12" version="1">MRSCCIAKTSVAPLDRVKILFQTRAPDYARYAGTWTGVFKASQDIYAETGIRGLLQGHSATLLRIFPYAAIKFMAYEKFHIAKTGARRFLAGSLAGVTSALFTYPLELIRVRLAFETHHSLAERSSLTRTIRQIYQASLIPPPPVASTANLKTASATSTPLPTTPGLTTTTIKHARVGEPSLTHFYRGIFPTLFGIVPYAGVSFLVWGFLKTDLVPTMFSPSTRERHRTWIDLAAGGIAGALGQTSAYPLDIIRRRMQVGPILPGGGDARHGFWDTARTIYKAHGWRGYFVGLSIGYLKVIPMNSVSFASWVALKNAFGLEGVSQGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M7R0</accession>
    <name>A0A2X0M7R0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BQ5605_C007g04680 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C007g04680</name>
        <name evidence="11" type="ORF">BQ5605_C007G04680</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="7">Homotrimer. Homotrimerization increases the affinity of HSF1 to DNA. Interacts with transcriptional coregulator SSA1 on chromatin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY62344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M7R0"/>
    <dbReference type="STRING" id="796604.A0A2X0M7R0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000027">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="10">
        <location>
            <begin position="95"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="234"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="449"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="554"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="316"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="340"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="460"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="564"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="584"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="608"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY62344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="624" mass="66960" checksum="3DC31EBDF96ED754" modified="2018-09-12" version="1">MIHRPARDLPPDSSPPDSPPVASTSRLPESLSPDGQLDGDTGDELFDDDYDDGAEMASGMVRGAEEDVDELETFGGEGAVPRAAKKSTSATSQKTQAAFIHKLYSMASLGRSNFDSLIDWTKDGKAFGVSRPNEFAKVVLPQYFKHSNFASFVRQCNMYGFHKVNDLLPNISQTPTTMDVSLAWEFQHPFFRRDEPDLLSRIKRKSVRPAAASGAQLTATRSSVASSSVVTCGSRTVSHTPQDAKEQLDVHVPAGRDDGDRPPCGNELSTDQSQGSGAKWKKEAQLHQCKLSVGEPRAISRREESPQRPIPDLRRTNSGSCVSSNRSPAPSFPWATFPPTNQPSRPPFPTPSHSPRPVTAGSADSSPLARQVASLEARVQSLTTALADSNAIASSTWSNAHTSMRLFLGVLEGFDLTRDQRNQLERCSSLLHGGEVDPSVVLPALAHSPSPPPWGSNWQSASPYAPRAPRASSSLNTPVTYGQPRPPANERHSRTLRRLTGSDPFPRPESDIPPGYGRIAPAISSYVSPYEAVSSAPPGITVLTHPPTYRAGINSANASFSGGPHPPSRPAYPVPTGQMRSAETLPSLASLLAGASPTGGVGRPRSLAAEHGDDRGDEKKKRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M7U5</accession>
    <name>A0A2X0M7U5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00588 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00588</name>
        <name evidence="2" type="ORF">BQ5605_C001G00588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY47900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M7U5"/>
    <dbReference type="STRING" id="796604.A0A2X0M7U5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012471">
        <property type="entry name" value="DUF1690"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07956">
        <property type="entry name" value="DUF1690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY47900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="202" mass="22307" checksum="C8C9D6846457ABB3" modified="2018-09-12" version="1">MGAGQSKTDSGAPEVDVSDDRSEQTFFAPRAQANVQLDENLINHLSSSSSSSSSSSSSSSSTNPPLPLSRQQHLDSHIQSRIRAEIERLQSQERSIRQQIEAALEKENLEKERSSSSSDEARPTSHSASLMDDLDRLEKTSQTIKGGKDLVAKDEWDKFEKRESGLLECLKNNKQTPLDCADEVDKFRQAVQNIETAFVAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M894</accession>
    <name>A0A2X0M894_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C004g02620 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C004g02620</name>
        <name evidence="7" type="ORF">BQ5605_C004G02620</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY66069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M894"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025423">
        <property type="entry name" value="TMEM205-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053009">
        <property type="entry name" value="Xanthocillin_Biosynth-Assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23241">
        <property type="entry name" value="LATE EMBRYOGENESIS ABUNDANT PLANTS LEA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23241:SF102">
        <property type="entry name" value="LD23009P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13664">
        <property type="entry name" value="DUF4149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM205-like" evidence="6">
        <location>
            <begin position="40"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY66069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="195" mass="21331" checksum="6FB9714729F7D5EB" modified="2018-09-12" version="1">MTPASHLGDLSPSLAHSVNDVTVRFGHRARRLQRKGPIRLGTVLGSTIWHSFLAGPLAYSHLPRQQFGNLQSKLFPPFFALQSAGSLALLGLYKRAGHVLSRHDSTSWVLGGMSVAALLNLLLVGPWTTAIMFRRHRVERLENTTYSAPDPSSKMKSLNRRFAIAHSVSSLLNLGFVFAVVGHAAWIAQNGLTMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M8B6</accession>
    <name>A0A2X0M8B6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C004g02640 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C004g02640</name>
        <name evidence="2" type="ORF">BQ5605_C004G02640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY66197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M8B6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY66197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="57" mass="6423" checksum="9531BD86C4333183" modified="2018-09-12" version="1">MDSECGGMNEIRDPGTVGRTSDLALGRNKRPFETHYQLPQGFLESVSILELEVIHYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M8H8</accession>
    <name>A0A2X0M8H8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C004g02710 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C004g02710</name>
        <name evidence="5" type="ORF">BQ5605_C004G02710</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY66823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M8H8"/>
    <dbReference type="STRING" id="796604.A0A2X0M8H8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040458">
        <property type="entry name" value="Vid27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013863">
        <property type="entry name" value="VID27_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040979">
        <property type="entry name" value="Vid27_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040768">
        <property type="entry name" value="Vid27_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913:SF0">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08553">
        <property type="entry name" value="VID27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17748">
        <property type="entry name" value="VID27_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17747">
        <property type="entry name" value="VID27_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vid27 N-terminal" evidence="4">
        <location>
            <begin position="2"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Vid27 PH-like" evidence="3">
        <location>
            <begin position="310"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar import/degradation Vid27 C-terminal" evidence="2">
        <location>
            <begin position="497"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY66823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="859" mass="95728" checksum="888950DA6A643DF8" modified="2018-09-12" version="1">MFLVNRLLGTNKPKVGAEELTVIDQGRLYLVRPDSLKAGRECIFIDASISIRRTTYEHTYQLVVTRTFQEGEEQLLEEDAENSDERAFLIDENLFLSVGPTLDPSAATPPPFSITWADPEGDGPEDEFEFVLAPAPDITALAHEFERLVWRCLWEDKTNRTWPTDAREVAMIEENELQQFMIERTAPQTLPASTKQPLFRSATPESDSDAEDFRPPPPSARKLTTADLDDSNDERYDDSDDERNQLAATLMKKATLTPSSTAKGKVKATSAPASAAPTPSRTKSKAKEPIETVTEQPPKRSTPGGVVKQALVSVEGDLYLYDRATGMFMMQEPLVQASIHRTMEAYWLIVEGKTGPWVSQGIDSETTFSEAEKSMVFNYRSEPEDGLGEGESSQVYTWLVRFPTSKPFEIIQQAVTTALFEDKFGSGTWQKLKEDEQAYQRRAYIDDAEMFDAVNEEEEGQGQSQEEVDELDEEEEEGEEGENDDERPKFGEGTQTKNSQLAVGYKDALSFVVQGDMIGVFKQQHDGGKKLKFVTSIVNISTPDGKKAFTPQKVMLHNQDTSMILQNPLAPGSLYRLDLTTGQVVDEYKVSDEVQVKSFLPDSKFAQTTQQQTFIGLSHNSVFRIDPRLSGSKLVNDEFKQYVTKNDFSVATTTESGRLAVASNKGDIRLFDKLGKNAKTALPALGDPILGIDVTADGRWVLATCRTYLLLIDTQIPEGAGRYGGSSGFDRSFPAGQKPMPKRLQLKPEHVAYMQEQSREGVSFTPAKFNAGLGADERTIVTSTGPYIVAWNFRQVKQGNVANYTLRRFSDTIVADSFKFGGDREIIAMLPNDVFVEDKKKLKAPNRDSISSVVKSYYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M8I2</accession>
    <name>A0A2X0M8I2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g03935 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g03935</name>
        <name evidence="1" type="ORF">BQ5605_C006G03935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY54941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M8I2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY54941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="52" mass="5834" checksum="041BF92163DDAF7F" modified="2018-09-12" version="1">MMQPAAAIHELWQKTSSTSRCFRDRANLQPGVLLAPLSVLSPMLFVVQCKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M8M7</accession>
    <name>A0A2X0M8M7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C004g02723 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C004g02723</name>
        <name evidence="2" type="ORF">BQ5605_C004G02723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY66926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M8M7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY66926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="102" mass="10943" checksum="B708CAB1CF72A1CB" modified="2018-09-12" version="1">MQVATTTTEIERSPLPAKSDAPSSPKAIDVAARSTAEQRRFFVHLNDIWDDGYEAGTQSQSTSSTFSSTAKFDGKGRTLSRDHGSRNTKDADANKAGCCTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MAI6</accession>
    <name>A0A2X0MAI6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C005g03395 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C005g03395</name>
        <name evidence="5" type="ORF">BQ5605_C005G03395</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY75024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MAI6"/>
    <dbReference type="STRING" id="796604.A0A2X0MAI6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05831">
        <property type="entry name" value="Ribosomal_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696:SF10">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="63"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY75024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="107" mass="10758" checksum="A7BC96F87374967D" modified="2018-09-12" version="1">MSSELATTYAALILADEGIEISSEKILALTTAAQVEVEPIWANLLAKALEGKDVKDLLSNVGGGGAAAPAAAAGGAAPAAAAAAEPEKPKEEEKEESDDDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MAM9</accession>
    <name>A0A2X0MAM9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BQ5605_C011g06615 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C011g06615</name>
        <name evidence="12" type="ORF">BQ5605_C011G06615</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MAM9"/>
    <dbReference type="STRING" id="796604.A0A2X0MAM9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF187">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0915">Sodium</keyword>
    <keyword evidence="8" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="11">
        <location>
            <begin position="73"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="11">
        <location>
            <begin position="326"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="527"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="571"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="615"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="730"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="820"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="528"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="615"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="664"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="820"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="839"/>
            <end position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY12818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="883" mass="95085" checksum="3F80D377FACED34F" modified="2018-09-12" version="1">MSSPNGGLAKVPTTPISIMPELDPETEELWSSRALLLVRSVFVLLSMPDLRLVPISPPPAPAPAQVLLLLILSFWVSYYLKIRRIRSIHETIVAMFAGMCVGLLVRLAPGNVIQTMISFKSTILLNVLLPPIILNSGYQLKQENFFRNFGVIITFAFAGTFISAVVLGVIVYIYSLLGLEGLSLNIIECLQFGSTLSATDPVTILAIFNALHVDPKLYSVIFGESILNDAVAIVMFETLSQFHGEKIHVLSFFHGVGIFLLTFCVSMLLGVVFGLACSLMLKHSELGRYTEIESCLVFLIAYTSYFFSNAVTMSGEFLRIRLITSLAMQAESVIHAAGIVSLLFCGITLKHYAYHNMSHRTQRTSRYMFGSLAQLSENFIFIYLGLSLFTQTQLVYKPMFILVTAVRAVSRVPITSRRRGLTLVACMLTQFAVCIARYCAVFPISKGINVFFKARGNRADELPHSYQMMLFWAGLRGAVGVALAEGMKGPNAIALRTTVLVSVVLTVVVFGGTIGRMIEILGIRTGVEDDDPESSDDEGGAGYAITNNGEGDIEGTRSAAGWNKAAGLATHKARRSLPNSRKFGGNGHAGRNEEEEGVVSAMDSPYSDRMALKSVVSTTPPSSVPKMGTLHPHGSFKGPSSPSHSSRDSGSDSEGDVLPSVSKAGTGAAATAGEGDNTRVWRDGQWFTVLDERYLLPVFSNATASRRQATKKAILREKRKSLVTLEGMDDYIEEGNGSPSQPGSPYLVSPSARSGGPLDKLRHQAPTDFTGSFSDILSSLVSPGSATFPVNQKRRASFSEAEGNEAEFYQGQSTYHSTITLGTTSSSRTSAPIRPRVTGSLSGASISEPSSMTATGRAPSPANGGGGTGACVPFFEGCEGYER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MB70</accession>
    <name>A0A2X0MB70_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C005g03655 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C005g03655</name>
        <name evidence="2" type="ORF">BQ5605_C005G03655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MB70"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY77507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="290" mass="31279" checksum="85652C08BC999B34" modified="2018-09-12" version="1">MSSASLHARTPSEARLFNLCWKDLQERRLGTSGTSRCSSSGSPSQSLHEYDSDSEEDQDPDFSMLTPSIIEEEEDAFVRAAAKALQQLQSGGVVPAGGAPRAILRPSLNSQSLFGPDYSFDYVHKHHDVDWCSQQDSPQASSYTNASASDGGYWSPASLSSSGSSSSGGSYSSISSREGEDGVDDYISSKPCSAESTTHSSVSSLAARRGRPMRIKLPPRPNSFGSISPPDPAAERPEATRNFNSLHRPVGVSNNFAGISLRCDKNEFESDLDRPLRFKSRSPSKHGFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MC76</accession>
    <name>A0A2X0MC76_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C008g05166 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C008g05166</name>
        <name evidence="2" type="ORF">BQ5605_C008G05166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MC76"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY79572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="383" mass="41168" checksum="54D767556672A171" modified="2018-09-12" version="1">MSKATPTSVQQFSQLGSTSSAHQDHSSHASTSASTSSSFRTSAVPHSQPSGLSNSDASTRARDGWTPYRGAGTDEDLGRFAAFSTTVVPGAEHQPSPGHDLGAETQNAMTVNFESSWNIAQTSPAWNDDDLYHQSHAKLNGEAGEGRNGWQDGDEIQALLRSGMLNAQLEEGWEQELASDQSRTYHADSTMPKDPTISAAQGQLSPVTQGLVQKVDALELEARLHLQSLLTLTNESGDDTLAIQAYLSQKSYADDVWGLPREIREVLTKVVEEQSQANDSDKNKALQRLNLVLKHLQETTISVSTGKDKNSAAFRGSYAASDDEGDSYGSALQHVAARRSSQLGPKHSSAMSTPPNGLVQDRAHDFTTLHERMAIGGSGHEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MDC4</accession>
    <name>A0A2X0MDC4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BQ5605_C005g03211 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C005g03211</name>
        <name evidence="11" type="ORF">BQ5605_C005G03211</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY72800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MDC4"/>
    <dbReference type="STRING" id="796604.A0A2X0MDC4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF9">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06390)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY72800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="148" mass="16197" checksum="4741DF9071181E1D" modified="2018-09-12" version="1">MKKGIPYEPRGTIQGFLNLYRAGGLRSLYTGFTLHAARDTVGTGFYFCFYDTARHLFVDNPSVPVPHVISTFACGSTAGILSWAVIYPVDLIKSKTQRNALAGSPYESPMSIFRRLSAGGVTKLYRGLGVSAFRSVFTHGLMCEFVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MEE9</accession>
    <name>A0A2X0MEE9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C005g03289 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C005g03289</name>
        <name evidence="1" type="ORF">BQ5605_C005G03289</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY73403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MEE9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY73403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="71" mass="7822" checksum="D1305FBC06971D81" modified="2018-09-12" version="1">MSHTRIFQQLPDTKRDQGYFSPLNPIGKVMVATHVSEPNAPSPNGPEPLSGLLCADRSWRVADALPLRLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MFG8</accession>
    <name>A0A2X0MFG8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C005g03490 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C005g03490</name>
        <name evidence="4" type="ORF">BQ5605_C005G03490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY76428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MFG8"/>
    <dbReference type="STRING" id="796604.A0A2X0MFG8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF152">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="416"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY76428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="438" mass="47731" checksum="9BD1A4D29E500F02" modified="2018-09-12" version="1">MVLEAVSHLVREVVDPNKAILAILASIVVFGLRNWARGFINQAERDLHGKTYLLVGCFSGPGLSLLQALAARGAQIVALHPDRTDAEVTQLILLLRSAARNERIYADQCDMLSIASVQQFAAQWSKNGKSGMVQDLEAKIDGVVFSDGLGSGLSAAPISHEIHQMQVRSRLAMIQFLLPVLLKSSRNSTSGVRIVSQVSPLYSAALDHSTILSLKCVLPDERASASATDNVFHGSSWRTQGRSALAAILLVQELHTRFATRNPNLLFISVCPGFTRSFLHASIGNIRRGGWPLRLLAYPFIWVFAKSASEASQILLTALLADVRKPEVIDPAAPPDEGAAVYRARKLEIPPVVILRGGTLVREGHEILTFRRVRPFGFGPWRRIIGLDSRNLLGSDLWAHETLAIDAELKLAEERKKPVGKEGAEGDPHPGVGRAKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MFJ6</accession>
    <name>A0A2X0MFJ6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C036g11475 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C036g11475</name>
        <name evidence="6" type="ORF">BQ5605_C036G11475</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000063">
        <property type="protein sequence ID" value="SGY95166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MFJ6"/>
    <dbReference type="SMR" id="A0A2X0MFJ6"/>
    <dbReference type="STRING" id="796604.A0A2X0MFJ6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF35">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="5">
        <location>
            <begin position="12"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY95166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="413" mass="47083" checksum="CC7624A71FAB99CB" modified="2018-09-12" version="1">MSSGLHTFIAPPRPFTVQFDSAEVDELDERLLRARWPLVDAVPDDRSLNDPAPFGMGPGPTIKLMKELAEEWRTKYQWKDTENHFNTFEHYKVEIENLNIHFLHHPSTHSNAKALILCHGWPGSFAEFLHMITLLTDPVSSTQQAYHVVVPSMPGFTFSDPPPTSKWCMDDTARVYDKLMTGLGYHEYGAQGGDWGSITARCLGALHDDHCKAVHLNFLPASPDGILSIIPPRLLLSYLPSFIMPDLRRQRLLRALDYVEKGSAYYAIQNLTPRTASFGLNDSPIGLLSWIAEKMIPFIDAAMTTQPRPTLTRWTLYETCTLYWLTHSIGTSFSPYSQNRHFKDFLTDPKYRLENMALSTFPNEIVISPVEWVKKTGDLKWNKEHTDGGHFVAVELPQVLTDHVREAFEKIWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MFU4</accession>
    <name>A0A2X0MFU4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C008g05202 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C008g05202</name>
        <name evidence="2" type="ORF">BQ5605_C008G05202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MFU4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="844"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="920"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1089"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1286"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1432"/>
            <end position="1640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1691"/>
            <end position="1711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1771"/>
            <end position="1792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="861"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="881"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="920"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="948"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1089"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1153"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1177"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1192"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1286"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1318"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1349"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1452"/>
            <end position="1464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1469"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1495"/>
            <end position="1520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1556"/>
            <end position="1566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1575"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1607"/>
            <end position="1640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1691"/>
            <end position="1701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY79697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1851" mass="195404" checksum="F045A800AED80557" modified="2018-09-12" version="1">MPHSRGASREPSAALATPATTTASTATTTNTTTALTSATTIDSSPTTRRNTRSLSQVPSSSNHAHPPAATTASRTASRSPSTSNSNSIPTSTRSRDPSPGTTRITRSRAASLAPADQPDPIQESDDEDGNDGHDETNEDGDETIKHEEQTQQTQDDQALTPEPSQPELDTRLIIEQVDPTIPEQNHPSLIDLPRATDLILEEEPVGPSAASIDPPSPPPPSAAAVKPEPEPEPEPESALVSSSDPSTLSTLTEPVPEPPTAEPASLADDLESQPKYETVGASEQVPAGEDAPIVEVLAGPEDASPYEPESSEALAPIPRASDVTSVEPAIEEEPPAAPRQTESEPKPERPVPSPKASPQVDEACTGAPPAPKPTLSTARSVKDEEPVPKPPAALEQAEFSLLTTATTTDTIPKATDDLTDPKQDKGNVAELDGVARQSAEDEPNQVGVKMLTPPISSVPTPFEGIVTKDPIPNTKVVEATKFPLTMDDDEGATTESIVADIIPEDEQPSAPATIPAMTPDASTDPAPESVPVSSADAEASRADATRTALKTSRTTLEAVSADQEKPSDHTADAIEPAGTNASSNIQIDAAASSEPAKSTKAGSPPAAANEAPPKSAEVIAGSGSAAGLESDSSGKPVKQSPPLPGPLVMPPNVQAMAPKEVRRRFNGHKVSCVLALNVELVKIACELQKSGPMDPIEHGALTQRLQSNIAYLSAMAEQASIRDGPLPIPPCPMLESPPTPKLGPRLAQLYSTLKAYFAAADRYEQQAQKNALIPSTAVASQPLPAPTLPNAALQPANGPVFTSNAMQGVVNLNGKRAIDTDAEESPPKRSGSAFTPAIKPELSSAAPFQTGSPARAPASLPTVSNTTSTSTIAPVGPSASPAGTATNLPPTTGMSPAVQARGPAAVNGSSIAFAGAQASPMGNQAPLQRHPSQSQPPFVGNAPPASLGNPNSIPSHLQMPPQVQAQHFAQLTPQQQSYLRQQHMANQQQQFQQYQAAAQAAAQAQAQQAQAQAQAQQSAVNAMQRQQQMQQQTQQAQQQAQQQQAQHQQAQQQQAQQQQAQQQQAQQQQAQQQQAQQQQAQQQQAQQQQAQQQQAQQQQAQQQQAQQQAIGSPAAQARRVPPIPNRQGSATPGPGFTRPMSALSQHAHVASPGSYSDLGNSTFSMPPPSSYLNAPTPGRPLPPPPPGPSQSPHPGQQQQQQQQQQQQQQQQQQQQQQQQTQNGFVMPGSANDHRPPAEQYASLQAIMSAASFRQLPPHVQEMIQRNAQALLYQLQATSMANARLAQQQQQQMQAGARPQGLMGAPGMGNNGPSALTLQQLQQQVAQQQQQQAAQQQQNNSLGRAGSPPFGQSPQLQHAQLRQTNNSPYAPSPPAGGPPGAETSGSAYFREQLAQQQQLQMRSGSPAVYAQSQNLLQQKQNAAMMAYQQAAASQGAGQPGTPSQFGYPPQRPAPGSAPASSPFTPGSLPLHQTPTPSAQSHSSPFATGTRPPTAPSPQHASPAAFSAAPSPAYSALASGSAIFPAQSPYASAPTPRNTGLAGGAVDSPSALTNKVSPAPPSTPAPTKPKPKRQTKKQREAEEKERKAKEEAEKKKKEDAEIAEKAKATAEAAAAVTAQQQQAQAAAQQQSQQQNLTQQQQQQFAIQQMQFQQQQQQQQQQQTFTHQQAMQLAQLEILTMQLQARQRLAQNGSPGMFQTQAPNQYLAGSPSQLLGQNQGMAGMAQQKNAQLAMVQQQQQMLLRQQQQQQQQQQQQQQQQRQQQQLQQQQQQQQQQQQQQGSPSPFIAGAGANAMLGRGSFNGNAMSSTLGGAWPSQSPLSAQNEWASASTTIAPAATTAIADEDDWSSYLNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MFU8</accession>
    <name>A0A2X0MFU8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C008g05212 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C008g05212</name>
        <name evidence="1" type="ORF">BQ5605_C008G05212</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MFU8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY79736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="56" mass="6041" checksum="A0E0380CBD15B757" modified="2018-09-12" version="1">MLLRTLDPARGAAITLTGDHAGQSVLLPRITLKTGPSAELPFTLHRTQFPSYLKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHD3</accession>
    <name>A0A2X0MHD3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C032g11042 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C032g11042</name>
        <name evidence="2" type="ORF">BQ5605_C032G11042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000067">
        <property type="protein sequence ID" value="SGZ04073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHD3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ04073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="410" mass="45501" checksum="CE62BD955700B240" modified="2018-09-12" version="1">MENYQAEIPFNTSSSNVNPRVVSSPPAGDTHTGRIDFVRLRIRVIGTPNLQRITQENRLWSRDLRLTIPWQVLNVSVRWGDHHVGRGSEAMSFRYSTARFGVVTVVLAGDPKQCLPGIRNNAFPLFHGSVRCSDRRVGRGSEAMPSRYSTARCGRVWTVVLAGACRSFKAKKSEAMPSRYSTARFGVVTVVLAGDPKQCHPVIPRLGAVECGPLCWQEIRSDAFPLFHGSVRWSDRRVGRGSEAMPSRYSTARFGGVTVVLAGDPKQCLPIIPKCCISLCSRQIGLELATPEGVVVEALPRIRDKFYQEMSAACSIDPVADPQQLGSGIRSNAFPLFSSHRLHKSSTLASWNADFWGEVGVLLDFVRLRIRVIGTLNARARAFRSGPTQFFAEPCLYRINIDGSFYFQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHE7</accession>
    <name>A0A2X0MHE7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein eL42</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">60S ribosomal protein L41</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">60S ribosomal protein L44</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C016g08247</name>
        <name evidence="8" type="ORF">BQ5605_C016G08247</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the eukaryotic ribosomal protein eL42 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY21519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHE7"/>
    <dbReference type="STRING" id="796604.A0A2X0MHE7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.80:FF:000001">
        <property type="entry name" value="60S ribosomal protein L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000552">
        <property type="entry name" value="Ribosomal_eL44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053708">
        <property type="entry name" value="Ribosomal_LSU_eL42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10369">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36A/L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00935">
        <property type="entry name" value="Ribosomal_L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01172">
        <property type="entry name" value="RIBOSOMAL_L44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY21519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="106" mass="12210" checksum="1619F86627D52C50" modified="2018-09-12" version="1">MVNVPKTRRTYCKGKQCRKHTPHKVTQYKTGKASLFAQGKRRYDRKQSGYGGQTKPVFHKKAKTTKKVVLRLECTVCKYKMQMALKRCKHFELGGDKKTKGAALVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MI08</accession>
    <name>A0A2X0MI08_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C039g11797 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C039g11797</name>
        <name evidence="4" type="ORF">BQ5605_C039G11797</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000060">
        <property type="protein sequence ID" value="SGY90295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MI08"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="234"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="453"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="453"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="493"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY90295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1106" mass="121795" checksum="2466C2F212573B84" modified="2018-09-12" version="1">MSQPARGDSDDIGGMASTPPPPPSSSTSNQPFDVAPATVVTLTKDQHDALVKNQRPAQAQEDDAISMRHLLPPVNPPAFPDDSKLTEDNYVDWDLAMSTTYAREVCAYLRKGQHDPSWPPAFHTRWEDYAARALASSLTVTTKATIGPLIQTGGSAHDCWLALAARYAPSDAQAYSTLIKDYFIPAQTLKKLAASGQVEGLDWTYSDLECVDFTCNACLASKAHRLPFPPSLFHASEPLALVHSDVLSFPEESFSHKRYLVTFVDDFSRKTWVYPIGHKSEVLPTVKTLRSDNGGEYVSTAFNGFCVARGIRRELTIPYTPEQNGRAERLNRSIVEGTLALLIDSGLPRTCWDKAAMFYIHTKNLSPHAALKGGVPNSFGCRAWATVPAHRRDKLDPKGIPLVFVGCDRHAKAWRLLDPSSMRVSLSRNVTFLETEFPFVAVPARVTPPSVPGFYPRPPPADAPATPLPPVLVEPTQPPSLDDDATSSIHLPQRPPEPAPPEPTPLAKVKPTWEYGDVAKVGLDPGKYGEIDARNIIAGPRTRRQLVPTLITREDLVGGPDGPTPAFQGMLRAFASTKAGFAEHDLSVVRDPANWGDVIRSGQQDTWGGPAHDEFDSLLNEYEVFEVIDSCELPVGEILLRSGWVFRTKHNQHGDIIDRKARLVAHGCAQRPGIDFEQNYAPVVKFTSIRALIALAAANGYHVHQADVNKAYLHGKLDKPLYMRVPQGIDMPGKILRLSKSIYGLRQAGTIWNAEIDSTLRSLGYVPTRSDICIYRRKHDGHSHYIALYVDDLLLVGPSTAEIDRVLDALELAYGIKRLRPAEYILGIQVKRGHNGSITLSQERYLRDILARFQFADAKPAGVPMQPGVVLDFENSSATPENRTRYLQAIGSLMYAAVGTRPDLAFVVSYLARFSQQPGPEHWTAIKHVLRYIKGTLDLGLTYRKTNQPLHGYSDANWGACLTTSRSTMGYAFILSGAAIAWCSKREHRVAKSTTDAEYLSLSYASGDAIHLSELLSELGAPVPGPVVLYGDNQGSLALAQHPTNHQGSRHVRISEHYVRERVAEKEIEVRYIATGDMFADIFTKALGPKPFIFHRTNLGLRGAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MI12</accession>
    <name>A0A2X0MI12_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C019g08979</name>
        <name evidence="8" type="ORF">BQ5605_C019G08979</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY23758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MI12"/>
    <dbReference type="STRING" id="796604.A0A2X0MI12"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03753">
        <property type="entry name" value="proteasome_alpha_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000015">
        <property type="entry name" value="Proteasome subunit alpha type-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033812">
        <property type="entry name" value="Proteasome_alpha_type_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY23758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="259" mass="28140" checksum="C455E7938307A5CB" modified="2018-09-12" version="1">MFSSKSDYSRNVNTFSPEGRLFQVEYAIEAIKLGSTTVGIQTAHGVVLAVEKRTQSALLDSDSVEKIMEIDAHIGCAMSGLTADARTMVEHARVTAQNHSFTYDEPIKVESITQTICDLALRFGEGADEEEATMSRPFGVALLIAGVDQHGPQLYHADPSGTFMRYDAKAIGSGSEGAQNELQDSYNKSLTLEEARSLALKILKQVMEEKLDHSNVQLAQVLPEKGFQILDEAELKPIIEKIEAAAKEAADAQMATSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIH1</accession>
    <name>A0A2X0MIH1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C011g06517 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C011g06517</name>
        <name evidence="1" type="ORF">BQ5605_C011G06517</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIH1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY12471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="275" mass="30152" checksum="8EFF03FCC3A360C3" modified="2018-09-12" version="1">MWTEQRTTLSSLNTNNFEIVKLPDGNYGHAVLAQDTTQVIVTMFGKIMLTDPSTGMPPVYLRDADMERVGRPELFSRQIGLELATPEAVVVDGLQHLREKFSQEMAPACSIATDSSIPFNTSSLNVNPRVVFLHHQLVTLHAHWTSVTGGDPVPEKGGHPPLPTWENDVDGSKYHNFYENAAEGIYNGRKVAKSYATPLPVNVDGHVDLAWKSKATGKYSGRIDFIPLRIRVHGTLNTSDSMNCGSPLRGSSQVKLATPVKRSTLDAGFDDILSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIW5</accession>
    <name>A0A2X0MIW5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C036g11544 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C036g11544</name>
        <name evidence="1" type="ORF">BQ5605_C036G11544</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000063">
        <property type="protein sequence ID" value="SGY96126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIW5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY96126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="77" mass="8500" checksum="94B7A5FBEB308A03" modified="2018-09-12" version="1">MEHQYSPSFWCQPDGEGTEEARCARSLFLIPVARSKARALHIIIPSSTKHSTLPARCELLASIDICGSQICGQESLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIY7</accession>
    <name>A0A2X0MIY7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Endo-1,3-beta-glucanase btgC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Laminarinase btgC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">BQ5605_C028g10582</name>
        <name evidence="17" type="ORF">BQ5605_C028G10582</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation. Active on laminarin and lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="4"/>
    <dbReference type="EMBL" id="FQNC01000080">
        <property type="protein sequence ID" value="SGZ13629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIY7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF17">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BTGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016017168" description="glucan endo-1,3-beta-D-glucosidase" evidence="16">
        <location>
            <begin position="23"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="169"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00043078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="SGZ13629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="486" mass="51821" checksum="A36610C8D40C9BEA" modified="2018-09-12" version="1">MSRMNTRAVLALVLVASLQALASPITGITFAAGPEQALAVRAPAPAAAATARSRVQQLGADRYVRLATLHTRDDEHLLEARLLNHVMIEPGLAIRAADESESEDTEEAETDDEAEFEETVEEVIERRGNSRVFATSARPILAGMRPPHVIPNPKDPDFGKLTATPVRTTTTTTSAKSTATTTPRATTAPSTTITTTTTTTTTTTSTRAVTTTRDAGAASIPTGLGCFPSNVRTIPTGVNYTAADLAVSWWCADSSEYAFMGFSYSVDECQSPSTLLADFTRMRKQFGARYVRLYGACDATWFNDALVDAAASANLGSRYSAFVKTMRTNPKAPFVFKNVAIGSEPLYDGVLSATNLATEILSMKSKMAPYGTKVTFSEMPYGLQINNGAPSTMAAADFVEGNVLPFFDSQATTGANAWGVVSWSLSYFASLAPGKIIRMTQTGWPSDQSVWKANTPTAVSSISSQASYYALLDSKCSWFNANGGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKG5</accession>
    <name>A0A2X0MKG5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C034g11309 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C034g11309</name>
        <name evidence="1" type="ORF">BQ5605_C034G11309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000065">
        <property type="protein sequence ID" value="SGY99857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MKG5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY99857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="103" mass="11559" checksum="AC3953A843398368" modified="2018-09-12" version="1">MRDASLEQRLERSAVDFLGQRDLVEPVLRDLTGRLSSMCGVRLFCTDLPECTVTVHDLRIRVLEPLVMLALQLYHDRKGEDGNKPAGGFFTTALRTPFTPTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLA3</accession>
    <name>A0A2X0MLA3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C030g10756 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C030g10756</name>
        <name evidence="1" type="ORF">BQ5605_C030G10756</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000069">
        <property type="protein sequence ID" value="SGZ07961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MLA3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ07961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="140" mass="15472" checksum="FB71614EF4078577" modified="2018-09-12" version="1">MAVAAGWLNVPPRIGTSAPLEAILPKPVARFAMEQRLPDPVLPQQASQYKLLNTARPYTIRCIRQVLNAKAFTNTLGLKGPPQPDNLRSFWKAVNLKAPYLTLGLHYVNFTSTSVNDLNKCTSRATSHVFLQSESILNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLH9</accession>
    <name>A0A2X0MLH9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C028g10571 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C028g10571</name>
        <name evidence="2" type="ORF">BQ5605_C028G10571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000080">
        <property type="protein sequence ID" value="SGZ13459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MLH9"/>
    <dbReference type="STRING" id="796604.A0A2X0MLH9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ13459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="178" mass="18476" checksum="B9919C5FA868C4E1" modified="2018-09-12" version="1">MPTARSIPKYRPAPTRLPPAKLPMFRSVVSHPPPPFAVAQAEARAQEGAGKGTQGVQQSGSTVPPSGSHQLFFSTAPRSLIPLTTSPSNHKLWNPPAADSKAGRAVERDESGRLAKFASRFAGLSMQDADGGTGGGKGGQFDVESDLSFLEGATVQSSGKALGKKEIVGVKSAKQGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLJ2</accession>
    <name>A0A2X0MLJ2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C028g10581 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C028g10581</name>
        <name evidence="2" type="ORF">BQ5605_C028G10581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000080">
        <property type="protein sequence ID" value="SGZ13617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MLJ2"/>
    <dbReference type="STRING" id="796604.A0A2X0MLJ2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="213"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ13617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1015" mass="113799" checksum="1BDB3485D25E2A2F" modified="2018-09-12" version="1">MARRLHRERTERMEYLVGRVQDLEAIPEWGEAETAEWTRTSEELKRAVEERARLLRIRAHVPEIASEERLSRPVHAKLAARNSDSKITALRLSNGELTHDIDVALDHTQAHFQRLYHIEPRDPDRVDRLRDEFLAPIRAARTCDDPRSDPLFLRRLSESQIDLLQRPITEDEVVAAIGTTHPGRSPGPSGVPYELYQTAPKAWAKVLTKAYNAMIERGSLSPKQGQGLVRLIFKRHKKNADRAELSSYRPITLRECDYKIFTKVYVARLNQILPDLLPPQQHGFVKDRRSADAALHLRLLIEEVGARRTEFPAAALLSLDQSSAYDLVEHDWIFAIFDALGAPATFLRVLRMLYSGDSTSARYIINGFLTAPVRLTCGLGQGDPASSSVWDIVFQPFLDALHRRNIALNLSIPALHPYPQSRAITSLAFADDVVVAVAGLGSLNLLDDLALDWRHATNGRLNTDKTVVLPIGRRWDPGQRPLVVKAAGESLEWIGLPFDPSGDTELAYANLIERLEATLEGVQHRWLTHHTRAFYVNRYAIPKILHFLAADIPPPEVVKKLDDMLVDFVRGGKGRTSYGRDIVFTAKLKGGLGVIRMQDVVDAVAARIWDVLLGGSGAIWQGLARAALQRAQPDLDLATDLWPHPSTPIPSDLHPRWRAALGVPKHHDAQVNPRTLTTANLLALPTLLGSLHTPIRGRQTIDAVHIPDYLRLQGYPKVADLYRRELYAGGGFPLWTPPADVLGDNSEYDRRGLPQRLAIAAWYRFTVDRHKNTPLAVAVAAGRLNVPLRIGTSAPLEAILPKPVARFAMEQRLPDPVLPQQASQYKLLNMARPYTIRRIRRVLNAKAFTNTLGLKGPPQPDDLRSFWKALILRFTPTRKLQHQQQHDTSPACLVCEAPVDDTDHYFFGCVDSRNVWIAARGVLCDALGCDTIEDAQYTTLQRLFGLPKLKAKLSEQEGAGWTIEIFTGMVLEMISSGRWRMQKHGTRMESVERRGVALEERMKLRTGGARGGRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLR3</accession>
    <name>A0A2X0MLR3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C024g09815 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C024g09815</name>
        <name evidence="9" type="ORF">BQ5605_C024G09815</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS37 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ25998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MLR3"/>
    <dbReference type="STRING" id="796604.A0A2X0MLR3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009851">
        <property type="entry name" value="Mod_r"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678:SF2">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07200">
        <property type="entry name" value="Mod_r"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51314">
        <property type="entry name" value="VPS37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS37 C-terminal" evidence="8">
        <location>
            <begin position="129"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGZ25998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="216" mass="24305" checksum="6452BBF8EDA1E284" modified="2018-09-12" version="1">MDPPPPLVDPTACSSLTAPASNVFSSSSGVTPTSTTSSPASSLPPDAILDALTASYPALATLSLEQVKELLQDPHLFDAYFNTTPQALQLHRSLEQALQENLEIAQKNEALRPRLQELRDQTMHHFQSANELKDRWQLLDRAQADHYQRFLPATQQARLSRATHAQEYTSEALVNAFLDGQIDDQVFVQQYRAVREVYHRRAIGLQKWQDGKVSWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MM89</accession>
    <name>A0A2X0MM89_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C020g09108 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C020g09108</name>
        <name evidence="1" type="ORF">BQ5605_C020G09108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000082">
        <property type="protein sequence ID" value="SGZ17267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MM89"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ17267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="53" mass="6034" checksum="00A4798801DACA30" modified="2018-09-12" version="1">MDTTNIGRFSANNAPFAGVTAVWYALKSRPSLATRPPPRLRPWLQGRWRTGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MMU4</accession>
    <name>A0A2X0MMU4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">BQ5605_C026g10200 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BQ5605_C026g10200</name>
        <name evidence="16" type="ORF">BQ5605_C026G10200</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ27826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MMU4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047496">
        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22705">
        <property type="entry name" value="FHA_KIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01365">
        <property type="entry name" value="KISc_KIF1A_KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01233">
        <property type="entry name" value="PH_KIFIA_KIFIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000047">
        <property type="entry name" value="Kinesin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022164">
        <property type="entry name" value="Kinesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022140">
        <property type="entry name" value="Kinesin-like_KIF1-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032405">
        <property type="entry name" value="Kinesin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049780">
        <property type="entry name" value="PH_KIFIA_KIFIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12473">
        <property type="entry name" value="DUF3694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12423">
        <property type="entry name" value="KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16183">
        <property type="entry name" value="Kinesin_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Kinesin motor" evidence="15">
        <location>
            <begin position="104"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="14">
        <location>
            <begin position="592"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="13">
        <location>
            <begin position="1606"/>
            <end position="1705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="23"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="691"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="763"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="887"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1233"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1569"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="845"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="805"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1582"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="202"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SGZ27826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1707" mass="188619" checksum="E7BC73DFAD036297" modified="2018-09-12" version="1">MKLATSWLTLVDTNGCVRPTSRCAPSWTPPPPHSGSDCSQASPSSPVLTPSGLCDLGRRGRRRLSAHRPSHRRRRRRGRTGAGGVVAQHSMSHPTANGGGGGGNIKVVVRCRPLNSRELARGAKPLVRMEGNNTYLDPPEATGTSRNADKETKSFAFDKSYWSAGPKDEPGYASQQTLYEDLGKDLLDHSFQGFNTCIFAYGQTGSGKSYSMMGYGSDRGIIPLICEALFERITSLSTDKLSFTVEVSYTEIYQEKVRDLLNPSNKGNLKVREHPSLGPYVEGLSKLAVQSFPDIEALMDEGTKARTVAATNMNETSSRSHAVFTLLLTQRRVDVETGMAGEKVSRISLVDLAGSERANSTGATGTRLKEGALINKSLTTLGRVIAALAAASGVGKHAGEKVPYRDSVLTWLLKDSLGGNSKTAMVAAISPADYDETLSTLRYADQAKKIKNKAVVNEDPNARLIRELKEELATLRTRMTGASNEATYDPDIPAEEQIVSYRTQAGEIKTITKAELQDQLEQSEKLMASVTETWEEKLVRTQEVQKEREQALEALGITIEKNQVGVHTPKKMPHLVNLNEDPLMSECLIYQIKLGKTTVGNLGSEVAADIRLSGSNILAEHCFFESSPDGKVVLHTLPGSLTMVNGRRISVDQPRELRSGFRIILGDFHVFRFNHPEEVRKARDAVHQLRSPLSNEFDDAGSKGSPAGTRPESPMSTAEADWSYARREAVVARLNGQHVNLDKLKDDELNRLYADILKVRHSRTASSATSGDRPESRMSFLDSVHEGDDDDEDEVGGRSGRHSGGTWTTGPASYSDSTLTLSQSPDFDDRVQAVKDEYETKLQTMANATVKVEEATAEKAQMEAKLKSLEAKMIAQRNKYDKKVKRLKSTNPSNGVPSDDDEFDTTPLTPREVRLARNAVQRWRRCQRVRMAEDTFSQAVLVKEANAISRELKKGTTFQFVVIGREIPSSVDGAIEGLAEFEASSDPTLATCQKPCIGVKVLDRRHRMISIWTLARLQQRMQLMRNLFKWVDNPEYSQHFAWEDPFYESEAERSNRFSYVGSATVSLAPLSRNLPATNVVQIHSPYTADPLGTCRVRIKPLSIETPEKPGVPLGRGAHPSIAAFVEGSKLTFEVVVDWVIGMSKSDFVAVHLQLSASSFLVKSPGEDDEIVAGDAVNLVSSEASEIRLRHTFSVVLDAERLHELSQGYAPVSFFAKITPAHLDKIERWDEARDSSTSSKIANAPSLRGDPRNSDVTRRHEDALIVEQTHDVLAKIEIRELGESGNYEPVVVVSSNPLDSGAFFLRQGLQRRIVIQLSHNSGRAWQWKRVAKVSLGDVRMLDARGRVHAATSAADVDLRGMGNPRAGFSSDGVATLNFAAAWDSSVHDSPHMNRSTPSGSRVLVRLHFQVSASNCSEPVPFSMDIGVTVQYRDARGPSKLMNFLGASRLSSSVTNVFSVRLTPCRTKNPTEIWRLNTAEMYVRGEELLANWRPRGLSLVRDFERGLKATIKAADVEAAKAVLAAFELTLPSPVEGRTSENRLTQAVELWQKRFGAVDEISFEREPVSTPSAVIDLTPPPMPSPNLSVTPSRSPRLRGTTTLVPRSDMFSKRGWVALLRDPTSNKWKKYWLVLRRPYLYLYEHSNELDETMVINVSSVRVEQSPEIGQMLERQFAFAIFTHQNSYFLSTSSMREMIDWIKIIDPSLAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MN83</accession>
    <name>A0A2X0MN83_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BQ5605_C029g10701 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C029g10701</name>
        <name evidence="12" type="ORF">BQ5605_C029G10701</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ15794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MN83"/>
    <dbReference type="STRING" id="796604.A0A2X0MN83"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051072">
        <property type="term" value="P:4,6-pyruvylated galactose residue biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF333">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 31 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="355"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="273"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="828"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1079"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="91"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="312"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="828"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="846"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1082"/>
            <end position="1094"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGZ15794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1105" mass="120074" checksum="67D1A38B06610FD2" modified="2018-09-12" version="1">MLPVNIVSTLPPTPTPTPSDSTFSSAPPSSTTSSPRSSCADSLPLEDNDLRQAPPLTLARRDSASPDAAASTSASVSTSSSSGFGFNYEGDSTASNSSDSYDSGNEATTLANSSSATARTSPSSRRYHHAPPSATSTAADHVASFAALSRQGSSSYMGSAQPSLETGTPRLGAPGYLYGSPNLNRAAALQHYAHAHWTDEGNYFSAVTSRAHSPGPDMDAFPSHRVISQNRSRGPSGATTPVHEDKESINYNTHHHQTSLLLSEWAGTIKADGSPVLGSQKKRRSGWWGRRSSDARRKNSVSARSSYSSVATPPSHSPNASLLPTSTSKANRNRTCLSAFGAALLRQTWVPTQPLTILFALVLIGCFVASLTAFLVTILRGDREPLPYRQYIQEARPFPHDLCDSLKPVSVFVGIFSVSAAADRRNIIRQTSARLTKPIDPRTGGPSTDVQVKFILGRPPKKWAKRIALEMEMYNDVVVLDIDENMNRGKTWKYFEWAAENATVPVYYRTGKGSKTQIGVGFKKVDYVAKSDDDAFINLSELERHLRVSPREKTYWGYLIRNLFMAGELYAVSQDLVQYVATYAPIRQHTFGAEDQRFAKWMRMHPNASTINWVSERVWIYDFPKAPTVYAHGFLFPDEFERIRLEGRRGISEEERIKRGGELSQAYSTVTKWRQEYVPPVKGLSMEEQVEALVEGGGRWSHQGWRSDNGRGPEAVRWDAVVFQKDDTRLVDSRMDRLGAAPDLNATGVKAGVPDATQVLPSVRTTKFAKDLFRDPEGVAAVQKSAKRSLVKRGLDVDDGAYSVDVEIHNSVIPDVDWIAETMVLSPPASQTSGGATAPSGSTVNTSSPSSPSAPSAPADADTTATVTSADPADDPRNEPTEQIRIGGHHYIIPSEHRLVPPPTHRFDAAAVSTRQKRMLGRAHGGTVAVHYIKYNEWFYETALALLGREKMWDHGYDTAAMASFGDVTSSEMSSVASVEVSRLPVWTGAGLVEQVESYWGGARMYGSPIVGDDGSIVEGRPAEPRREVVQNLPDSTMASFGGRRTTSAVSFAVALEEGVEAKIGGDVHEPSAVLEVKMSEEPTSSSPPTASSELVDNVLVLQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPL1</accession>
    <name>A0A2X0MPL1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C023g09720</name>
        <name evidence="9" type="ORF">BQ5605_C023G09720</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrion-specific ribosomal protein mL54 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ24389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MPL1"/>
    <dbReference type="STRING" id="796604.A0A2X0MPL1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013870">
        <property type="entry name" value="Ribosomal_mL54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L54, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08561">
        <property type="entry name" value="Ribosomal_L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGZ24389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="146" mass="14785" checksum="923D06D8AB1D5832" modified="2018-09-12" version="1">MSCTCLLQTSNRAISSTSSASRLVLKAGFSSQSIVRAAAKGTGAKAGTTAAASPATPTPAAAAGTASLSSCPAGTVLPGLNFSKTGSDPIAKEDSEYPSWLWTLLSPRKAPASISGSPKDVALFDQKRKIKISSKTAIRARNTLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPR6</accession>
    <name>A0A2X0MPR6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C049g12434 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C049g12434</name>
        <name evidence="4" type="ORF">BQ5605_C049G12434</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000111">
        <property type="protein sequence ID" value="SGZ30695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MPR6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050872">
        <property type="entry name" value="PPR_P_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46128">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR CCM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46128:SF342">
        <property type="entry name" value="PENTACOTRIPEPTIDE-REPEAT REGION OF PRORP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12854">
        <property type="entry name" value="PPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="808"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="917"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="985"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="79"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="179"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="86"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="201"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ30695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1411" mass="155959" checksum="AD3791E388DECC11" modified="2018-09-12" version="1">MSVRPRSRLPSSHVLLEWIRPDRAAAARPAIAVSTTSSWSSPSSTRLNSTQVSSAASSLTLDFLYPSFGFFSRTLPTASPSPCPSPSTSSSSSSSSSSSSSSSFSSSPSPLTSSSAPYSAPSVDLITGVRIPRGTARRVPVSSAPTSNSRRPSSNLLRACPCGRTTVCMRCRATSSSATTHETHAGEHMQHVRPDSSPIPVDRTSSTTSRSLVSDRSGQKDASLTEEGSALNGSGLPPAQNGYPKTQKQRRGELCPATARPREEDLVLHACLSIVDKRPISHDSPIDADAISVPWIRDFLRDSIYKFGREPISLRPVPVASYSRRGLRTRLVSRFESVTSRLDQLQALTTWLVEDPARLQELELEERLDLVKLTSSFVRALKLPILEPGGPASVEEEARRIVSLRHEAGRKMEEYFHRLVMEDPRHPRSKAMLWIDAIALQDRLPAALSFDPDVPVDRDDILSKTYLAHLQQIFAHGDERTEAHAKRRKTAEVVTPILLEAWSRNSSIGAEQALHLFCSWDMVSLLRLYDTVNPVPSNLRRQYGELLGQLGPSPPEYYSSLPSRRMRWVMGPHLVEYLSTTGSTLRALQIKTMIDEEKALDPLDDMTRLRMNATLLEGLLGMHYNLDAEVLAVEVLQLARRVAEAGAMNDRTKAVVVHAYKMVIRSAAELGSQNRVDALAKELGQLPQAGIALEMVARNVRAASRSTGLADARVAMTEAVHVVDPTTAKDRARVVSNLVEAYISCDDLEAAIKALDDYLLAHGDRPTIGTINSLMFGYATRHDIDSTYAIFRRLAAGEWGSRASLNPNAGSYEALLCAHANVRDFDAVIGIMSKMREEGFEITLSAWTTLMNLYVELGQYREAFDIFAFLENSPNPKFVPDTVTFNVMLKAAVFTETPVVIQLQWFQQALQRGLRPNMVTYHTLLQSVCNAGLVDVAEEMFKVMDETLARNLASFSETSTASTESPSSAESPTSLPVAMDDVRPDVFTFSILLNAYIKAKELVKAQACLQEMKSRGIEPTSVTFGIIVASMVAGAKRASPTIRARAKTFARNFLQLSPLDVHRKDIPKSAKRDRVLARGDELLHIFAPILQAEAKTANGHTVLDTFKLVLSSGARPSIELYTILMDAFRRDAIVHSAPDSSAMGVADVVTVWNGLHASVLDAYGYPVQTQRVVPSLPSIFSDHLRMRSPTRRISAAHCSDLCLPITILIDTLSSPPALEAGHGHDLSRIWGDLCAEGFRFDAGTYNALVRAFIRQGEMERAAWIIENLLLVRSDEASEDEVESRFRSAEQTFWDIWIARGLGNPRMAGRIASASRRHALFDFDQLTPDMLREYMSRPSNPAPMSNITFVEAMKVARIEKLRRLWKVSNKTWNELDEALMSGEMREEDLERRFPVAIDGLFRWRAGRVKPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQ04</accession>
    <name>A0A2X0MQ04_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">BQ5605_C016g08069 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C016g08069</name>
        <name evidence="14" type="ORF">BQ5605_C016G08069</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY20476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQ04"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0229">DNA integration</keyword>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Retroviral polymerase SH3-like" evidence="13">
        <location>
            <begin position="404"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="12">
        <location>
            <begin position="652"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF25597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGY20476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="828" mass="91617" checksum="9345EA1590459B40" modified="2018-09-12" version="1">MSSASEPDSHNRAGMNRLYLKDTKGYKSWASKAYLNLRGDALWDVVIHSVDSLVADYRSGSAPSADVLPTRTSVQTADKVAAFRDKANRRNELACKFLANALSEEQMGHCEHLDTAKDIWDTLKGIHSLGQSSRTMDLLSVLMQPYTGDIPFKGFRQQAMLVRSLPDQYDSIVGNFASDVDIHMDWNAFYPKLLMNVELAESRNRQKASLSDRIVDDSSLVARISTTAPKDYSKSYCSRCKVHGYERGWRLCTSRNNNANVSAPPSDSDSNSNSNVAAIGADEATLMIYTFPYSKAMPVFPWIIDSGAKVHGVGDKSATEIPSGSRVRESVGHQCSFVYTNGSNVRVRSMLLDSGLPMRFWSDALAVATFVLNRRPHPRISGKTAIEVLLGKKPNLTHLQPFGSTAFVHGPKERRTKLSPRSIQGVFIGYSGEYNYRVWVQSSNKVYVSRHVSFVDTSPRAPSVVTSTQDRVDAPIPVFDPRPPSPEMLPVTPVSPVVTPPIGADQPGGDLGVVPPMDEEDEDHDRLEDFHDAEVSLDGEAEVALAPRERCAIVRTGPNPGKFENVDRSNILHAGSRRRPQPPDKVLPIIAAIMVDVLDTPPLFHDKLFYDAYCAAVFAEEDIEIPKTFEEAMKSPYRNHWIEAMEITWHEGIRVLGTIWVYNIKRDANGKIIRFKARLVAQGFAQRPGIDYHDIYAPVARSSTTTTDSEILSASSVTREAIWLRRLAGDVGIPQSDPTIIQEDNAACIQIAKDPVDHMRTKHFDIAHLFVRERVASGEVEVEYCPTHVNAADLMTKPLGPQRFDQLRALLGMVSLGSLTGGSVRSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQT9</accession>
    <name>A0A2X0MQT9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C019g08871 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C019g08871</name>
        <name evidence="1" type="ORF">BQ5605_C019G08871</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY22909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQT9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY22909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="105" mass="11781" checksum="FFA1037E3B88DC8C" modified="2018-09-12" version="1">MLSRPDVDQLRATADRLDICLDVEDWTNSDCLLDEDSEGHFDVYYYDANFSPDSVPWARRIKLETGAAARINSITRPAHFDNCIHALRADTTPCAFVAMGRATVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MR01</accession>
    <name>A0A2X0MR01_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C025g10014 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C025g10014</name>
        <name evidence="2" type="ORF">BQ5605_C025G10014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000087">
        <property type="protein sequence ID" value="SGZ26975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MR01"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ26975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="71" mass="7695" checksum="C68EF094815E3CA9" modified="2018-09-12" version="1">MSTSSDDHGPGTSPGNASQLPKSGKDEAILLVRCLPTNHRRSNQKAKTQKHYVNESSCARRKLVHGVQVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MRT0</accession>
    <name>A0A2X0MRT0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C027g10316 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C027g10316</name>
        <name evidence="1" type="ORF">BQ5605_C027G10316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MRT0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ28339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="106" mass="11767" checksum="8DD0B9DC9C475EB1" modified="2018-09-12" version="1">MTVAWVLRSRLDDAIVLRRKLHAASRTDTDTKRPSLSAGIYCGEFRTALRHWHLTASDLKTIVEHLPSQVHLDKLSILYAVNATSGSLAAANETDETLTAPCFHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MSF2</accession>
    <name>A0A2X0MSF2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C048g12411 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C048g12411</name>
        <name evidence="3" type="ORF">BQ5605_C048G12411</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000110">
        <property type="protein sequence ID" value="SGZ30568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MSF2"/>
    <dbReference type="STRING" id="796604.A0A2X0MSF2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF118">
        <property type="entry name" value="BETA-1,2-XYLOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="2">
        <location>
            <begin position="317"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ30568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="595" mass="68536" checksum="E0CFC721609AA0B6" modified="2018-09-12" version="1">MNGIRPGEDPYETVRHIARMGRGRVLCCRPRFLITLMLVSILTLLLLPAKHRSAAHNVLTHAGRTTVRRILYTTPHLSPGPEDDDSTWTVTTPHEFNSNGHLIVEPVSTFGKAPPAPHPILTLIQRAEHEWNNRVQRQSKTLREAVYEYRKRYRRNPPKGFDEWWAYAKANRIVLTDEYDQIFKDLQPFWALEPHDLKHRVLVMQEREETFTIQVKDGEVFELGEQAQLKRAKDFRELIARVSKHVPNVNLTFTRHDQPACQLGWFHKERMLELAGEGERGSLSLRLWTSEFIAESDLPLTNWGKRVSPDSPLRKIETEVLEAAGQPADKASIQAKLRKAYATELSQKRSATCPLFTFAKTNIHSDILVTPLEQYSDTYIGYDPDWEKKEYNKLMWRGSTTGAEFAVGYDWRSSQRARLHFLTNDLKGQKNVLISEEEGPIKEEMMQMHNLNKAQCDVSFSGGPVQCDDETCAIMKEEIEFRPTMGLTDSYKYKYVFDVDGNGWSGRFHRLMSMKACVFKSTLFPEWYGDRIQPWVHYVPIKVDYSDLYDALTFFRGAPDGTGAHDELGKKIGLQGKEWARTIGGNKIWRRTCSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MSR3</accession>
    <name>A0A2X0MSR3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C049g12451 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C049g12451</name>
        <name evidence="2" type="ORF">BQ5605_C049G12451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000111">
        <property type="protein sequence ID" value="SGZ30748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MSR3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="548"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ30748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="577" mass="64661" checksum="019DE40A1BA7D810" modified="2018-09-12" version="1">MARGLAQHGGWCGLQHVHLSPGLTTFCSLPLSVVYLDSKPSDHTICCLSCLLPVTHASVQSTSSPEMGSVLSSSATVQTQQHHISASSIAEDGRSTTLASRPTTSNSSNSMSHRIEKVQDEIRALHDAVRALPSTSRLSSSQKETHVLYNLQRRLEKMQYCLRHGVRDDDLDSYTPPATRSNDRNDWNDFKTSRFFRCLLEKNGLEGKCSVCLPDSSRNRLLSITRRYSDRQIHHSEAYKVPKDFSALQAIGSRYWEQVKNSPELWEQWKEARASEARDRKETAQPLKRWRINSATISKLRRRYENAMNELVEQYAEGYGFDALVIVSSNKLENKNDRFIVSTLGGAAFMRRQGWDSDQQKDILVNFTDCVNGTRFNQEQNEQYKMRANHGDVDKASQRVLCAWYSIIIDDHYSEQPFHGSAPTFCSLVLNICGRADQALRRRHQRNRSTQPYVLSKLTSYNQATLAKDPIALIVEFGNGLQERDFRSPTNGKKPTVADLRRIIPLMRQGGLTFSPNEEIGQGSFDRTRAEGTVTTGQLETEPEDQVSGSDSASASDLGSDSNSNSDSDAHLGAATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MT98</accession>
    <name>A0A2X0MT98_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C045g12203 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C045g12203</name>
        <name evidence="2" type="ORF">BQ5605_C045G12203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000115">
        <property type="protein sequence ID" value="SGZ31563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MT98"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ31563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="460" mass="50246" checksum="41D4B669AF304338" modified="2018-09-12" version="1">MPVPQTPLSDSDSDEPNLGDSSQSSAGDSESESDSHSHSESEFEDVAIDHRRAIRLWTAIHGSHRNATGRMSQRKWTSLKRWAARRYYSELKMAAKLGIFHARLVQAVKKFNRLASKGNAWSRFLSDPVIKSKSQSITKLGAHLWNFLRDQGDLASAQLGEDDEEPVRAAFAAAEAGNNTTFTSIVPPTIITRSPSDIPSPTRMEQCKKYIAELRDLAQRMSKLYGSTVHSMGGLRFSAHCNDFKDPSGNSLLSNLASKMSWDETLKANEAADLKEGEPFIASYARMRPSYPKTRSMDSATRGVLGKWHGTLFRAQLNSALETIHRRSNTGSSTGDFTPQKKMIWSTQGLKALGVKLRIKPGTKSRYEMALHHSAETSLKQTVAQLKAIIDDLRHGRLAIVPSADPNDNTDAEASDDDSNGGEGPLSARFGGAGDEGGEVRGGEEDRERNSGGVAEETGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MTR6</accession>
    <name>A0A2X0MTR6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C040g11844 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C040g11844</name>
        <name evidence="7" type="ORF">BQ5605_C040G11844</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the actin-binding proteins ADF family. Coactosin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000118">
        <property type="protein sequence ID" value="SGZ32281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MTR6"/>
    <dbReference type="STRING" id="796604.A0A2X0MTR6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11282">
        <property type="entry name" value="ADF_coactosin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000018">
        <property type="entry name" value="Coactosin-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829:SF56">
        <property type="entry name" value="ADF-H DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829">
        <property type="entry name" value="CORTACTIN AND DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="6">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGZ32281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="144" mass="16033" checksum="D37692FE98DE84E0" modified="2018-09-12" version="1">MADVSSPDIAAAYEDVRNDKSETNWLLLDYEGDKSDKLNLTATGTGGLEELKTKFADERASFAYARITYSNDKESTRDKFIFITYIGSGVRVMRKAKISVHKSEVQKVLRAFSIEVPAENEDDLDEGPIVTRLRKAGGASYDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MUJ5</accession>
    <name>A0A2X0MUJ5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C064g12778 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C064g12778</name>
        <name evidence="4" type="ORF">BQ5605_C064G12778</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000132">
        <property type="protein sequence ID" value="SGZ35118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MUJ5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="GIY-YIG" evidence="3">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ35118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="116" mass="13623" checksum="4C17A9399B00525E" modified="2018-09-12" version="1">MHSHHFNQARSSSPTCRRRRRQTPPLPLLLLLLLLLLLLIELRPSLKQPNRTYIGSTPDPKRRLKQHNGLVKGFEWAWQNLIFQDIYTNKTFNSFVVVVVVVVVVVFCFFFGQSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MUV0</accession>
    <name>A0A2X0MUV0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C143g13440 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C143g13440</name>
        <name evidence="1" type="ORF">BQ5605_C143G13440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000140">
        <property type="protein sequence ID" value="SGZ35642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MUV0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ35642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="101" mass="11121" checksum="B4F0373276A48A6B" modified="2018-09-12" version="1">MFGTSEAQGQSAQSRRSGRTIEIFTGLVLEMISSGRWGMQKWGTRTGGCWEEEDHLGGEVEAEGGRSLGEERAVEAGFDFPPHHHTHTHQILVTSFSPTVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MXK3</accession>
    <name>A0A2X0MXK3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C005g03364 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C005g03364</name>
        <name evidence="8" type="ORF">BQ5605_C005G03364</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY74450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019783">
        <property type="term" value="F:ubiquitin-like protein peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="7">
        <location>
            <begin position="913"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="1218"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="16"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="62"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="997"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1122"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1496"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1612"/>
            <end position="1632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1649"/>
            <end position="1693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1001"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1052"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1509"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1612"/>
            <end position="1623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1657"/>
            <end position="1666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY74450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1707" mass="192093" checksum="6115C481F84F3945" modified="2018-09-12" version="1">MAPVALIMSTGEMSQLLQNKGGRPPIALQEQSSPEGYASEVDSEVDEDEDSLQVLAALVPVPSKSSISSPSAVSGLLISPKSRSRDSDEDSADEGYYGVDNDNSDEKLIDNIFSALLLARNDKKILDRHTYEPSRQDKELSNTTREAIFSNMILTTAEHNELRLRPLVLNCRKPRSGWEFVRKLPVLELPKFMATEKHDWAPRKYERCLAVVERPYGDAPSSTDHQHPSEVAVGIEWRPEVPITLREAWSQPGEGRPVAEVLRITHRCSGACKRVRVKDGKLVYKKRDNDKDPGKTCSTQLKILVQADDLSSALVYTLGNQEGRQPPPNVRRPAPFIRALAHQEVFRQANTPTLAFQSECVLQVCTRSFHFSRLTISSFLDDGLDHFTDMNQRMSFWEKQNEIILPQYRKVGAKQLRNMFRAKGRQNAQHGSSLYSLARTAELRPFTLQNATEPETRGVAYFQPFNEKTKQPLICVLASLHSIDVLISFATVGNDSGDWSRFVGLDSSWRYLNENRAPLTALVATGLKDKLALGPMLLSSDVKADTLVIYLDTVKRLVEERAAILVRTAFFGRSRSRPSVPSTICMRTSEARENGPNLPGSSPRLPNLLQNAEFILENQWQPPNFMIDKCRTELNALTLYCSHDFEFLMIIVFCIYVTIGKEKHNLNFHIRLCQFHVVQAIIRWSSDRNDGERGNTVKPSRIARKTLINIFYEFRSIIQRFRFIRTEHETDAEATARRSAEFEEKKRAFFEKSDAWIDKEFRSRRKPAANKSDVTKKSELGCNSREEEQLQAKKDNFRAYFNVNWFVQEWIDDGLPLGVSRETIKTNNVTERAFKTIQQEHLHGRANKRIDNLVVVLPDNALVYDIWKDVSNAKPDHVLRDTLANSMDIWELGQFRPTEKEGQWVLSLRSMDSSITLDTRAPYCPCRAFKQTGNKCAHLWACDLLVHNGDYHTAMNRIMAAAAAAKAMPDMRDGTKSSKLHDASVEALVDKVLDSKMPSALEDDNEPDEPLSEDELDERDEVDSDVEDEGQRAADIADVAEFQPNCSTVKGRSARNRPLQPHRSKKTAKPKLSKSKSNSGVTLEHSGRVDGKATAAIRRLIRDKLNPDQLRPKTSKHTIFENGTTQFGKTPGRPRETKFSNSLSSTKDHAAAKRMAAIPELAPLQERRLPLDIYDTVQPEERRSNVSAVKDIVERIPNEVQKVDWDVFLDIHAGDHAPGLNLSSLREMANANLWLRASHIDAFSSAINRFQGQLPFNGRSEEVHDFEPTCYAFYLEGGKCAKGIGGTRPTERQQGVSSDGSSRAYLSIIIDRRPASLFALPLYQIILSRTPVLLFPTHVTNHWILVEARLSDCTSRVYDSLFGRENMRKEANESLDSIITFLETRAEGPIERITGGIDRPTVPYRNWKRLIVKAAKAGDQPQPDRYPQQTDGNACGAFVCRAMETLVCAAVAKMEPDWSWGPQVEPERFYLELRDYMLDVTLHSRLRCDMSSSWFSGSPESPTVSCATRDPDNTMDSRKPPGNTQPGDCVGYSSDDAEEVSQHLSKFQDRESNSLALLVPLIPDYHSMILPLFVFALARNVASSADTVITQHPQPGGLSHVESVQGNNMSTARTRLASDQSDSPKNRPTLAFPSFSPVFATRDIEHLPKKCKHSAVPQESSPSAVVTPSKRRHSEAESETPSSSRRKACSQCRDRKLKCDLGHPCSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MYW4</accession>
    <name>A0A2X0MYW4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C008g05025 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C008g05025</name>
        <name evidence="8" type="ORF">BQ5605_C008G05025</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MYW4"/>
    <dbReference type="STRING" id="796604.A0A2X0MYW4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050838">
        <property type="entry name" value="Ketopantoate_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765:SF2">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016035845" evidence="5">
        <location>
            <begin position="21"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="6">
        <location>
            <begin position="102"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="7">
        <location>
            <begin position="290"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="7">
        <location>
            <begin position="447"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="538"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="540"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY79060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="563" mass="61818" checksum="59640B16B6EFBE52" modified="2018-09-12" version="1">MRIHCLGVGSIGSLLATSFAATPSPPTIRLIVRRKDLLANLVARPTPSESTSLRPSSASNTPPRVALTIERDGIPHRYAAFEIEHTLTPTDQLQIDPRSAHVVPSISSSKYPSTGGGLSRKDPISTLIVTTKASQALKAIKHLLPRLSSSSTIVLCHNGMGVLENLLERYWPDDQHEDPYSDYGHRRGRPSFVCVTTSHGVWRRSADHFVHAGLGNLQFGVVPNRSTLSSIQSHWPDEPSSNPLLNPRSLISPTLQHLPTSSSLHATLDLLLRTTHLNPIWLPLPQLQIAQLQKLAINCAVNSLTAIVGVHNGALVGSRAAKDICREVARECSSVFAAHVIDPKKDGEAEQPSALSDFASASYDDSTPTTIDPGPARTFAHNHALSEQSLLQAMMKVIFATSTNISSTLADLEAIEPIQDLTRIDPRPLPTGEKARPARLRSKFATKTEMDYINGYVSALGRKYHIPTPLIDGLATMVKLKEEMIVHGAVERLRTQAEEKKVLFLKEKTKLASSADQGIPKKTKGRRRLEKVLALRQKHMQVERERERDKILDRQGGSRGDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N5D7</accession>
    <name>A0A2X0N5D7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C005g03686 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C005g03686</name>
        <name evidence="3" type="ORF">BQ5605_C005G03686</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N5D7"/>
    <dbReference type="STRING" id="796604.A0A2X0N5D7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF3">
        <property type="entry name" value="N-TERMINAL KINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="38"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="708"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="869"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="709"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="727"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="750"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="922"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="939"/>
            <end position="949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY77641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1048" mass="111603" checksum="0C98C59AF6DADA40" modified="2018-09-12" version="1">MSWLSSLAGSVAHTVISASASALSGGNNVPGLPGYTLGDKLYHFDRRSIWTVWNATKKVRTRTTAPFTLMDDSSSVTVFSFDLNAPQQPNPGAAGYSNDRKAQLVLAKNALRKLRALRHPHILKFLDGVDTDTTVWIVTEPVRSLSLELDSAGTPLAEESKVYGLLHLVTALAFLNKDGASIHGNIRPESVWITQGGEWKLGGMELTTRKDDDSGVIWNYAGLLPDARSYTSPEVRRDGWTALKGHEASALDSYQLYLLIFVIFNGALPPIFSSSSSSPPTLPGTRGQTPQNIYTTWRRLGNPNPKARLRTDLFLELGIGSESGTPGWWPSNRLVKLSAALEGFSLASEAEKLELLKMLKTVSDANATVAAGSTKKRASNALPDEFLKYKVLSSLVRTFEFGGGGPALLPIILNLASGLSEQEYAQSIIQPLVRMFATPDRATRMALLEGLDKFADKLSNKDVTEKIWPHLLSGFGDVVPVIREATVKSVLLIAPKLSDRILNNDLLRLLARSQTDPEPGIRTNTCILLGRLSRHLQPTTNRKVLVPAFARALRDPFIHARIAGLMALMATADVYEKEDLAGKVIPAMSICLIDREKAVRDQGYKAIELFIKKCEQLTINMPETAATVDENGNPIIPGGVAGAGGASATSTTMAMKAANATQPGLATNAAGAAGALAGWAFASVSKKLSSAEAAAHMSAGPSIPASAPILPPVASPPKPAGRATNGHGPQSSIHRPFQSSSLALPGGANEADEDDEDDEDDEDDEDGSAGPEDWGQDLMDVNADEDDWDQFESGSSAPRKVDPLAARLSSTKPKPVKLGGSSANKASKMPMMDFDAAADAWDAEEASGFGGMNKSALLASVRKPPPSLMASAVPAGPKQVVSLAPRPTRTPIAVNTSPRKPIRPLVGTTAASRTPMSPPRPSNSSVESSPRTRQLSTPQSPPPPPPAPNPFADIISSPQPRVFSPPPPAPVLPELDSDPIPSPRVASPPLRTASPAISVVSTSNETIKSNEGEAVGTGATVWMTKEEKMAHAREQRRLRMVQAKVRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NB03</accession>
    <name>A0A2X0NB03_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C049g12416 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C049g12416</name>
        <name evidence="3" type="ORF">BQ5605_C049G12416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000111">
        <property type="protein sequence ID" value="SGZ30618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0NB03"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1265"/>
            <end position="1550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="561"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ30618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2083" mass="232132" checksum="7EF4A54EB20FA6E5" modified="2018-09-12" version="1">MSTGDPGSPPPAPPPPVSATSVQPPRDQIPISSKKTQATGPATAAPNYAAAASQMATQSPEQQQQQQQRAKALGSLLQAMGAVPGNRMDRWVQAIYFAELYPVATATSLKFSALNANRSVENIFDYALEVTLSHQSASRASHADKTDLVACVTRLLSPISPICFEPGVPLPDHLAAYRPQILGVQHSSILRNGAAHHRVTVGFVTGEARDAALTTPPALTWRSAKARFAKSHRFHHNMVELRINVGVQGVPSMDAIIKSFQLLVQDLSGKGHSCQLVQVLRIISVDNASAFAHVAGDYSAFLHFDDDSLFKRPNTTLKEILPSRIGLPTRGIPVTALRHDYEKEAACGRCHFVGHVGTCGLDQESKRKEAHNGNGNGNTNPNKNTITNDTNIVEAEAPIPVPVVNRIASQNRFAGLEVEEGQEEAVTGQSGQGPEESGEEDAGDKADDEDSEDSEMESEATAKTEVIKLKSEDESVLEDCGGSDGEVIDEDEVMADGRGETEGKVATEMEEREVATEMEEEEMATEVDDVDEAGGATKAENAEATDLGETNRLDNDDDSDATATAATASRESTPHEPTPPLSPETLAKSLREGEEWDRIRANWVEQARLERDQSIERRLDAETPLVRHNFATWDEDGEIRSINIRGTAAKFKKPVMKRSQTAADLSDPSDEPTDAKRVIIKGKSRVVVKDGTEGRRVTRSMSAAAAMPVGVTKVDRGKAKGVAEEKRWSDHEPEDDRFDLNYPLMIKHTIITWNVRRGMGVPEKRRDIYNYLSLFKASAILIQEHFIRPHLWQLIKDEYEGKLFINQHCLTLIPADSPLIDAELLRTHSALDGRLLVTSFRLRGDIKILEINNVYAPVDPKQRAKFFDKLLFHKTQKSHLRLLGGDLNDCPRPEVDRRNQSRRGHHWPILIGKLDSAYTDCIRYKHPITPSFTRPNPNRKRPNSFSRLDYFLLQRTHQKRLDQASTIYDYPKELSDHRPVLIVLALSDDPDATLPQLSLPTTSNQLHRINTTTFKTVEFQRMMEGWLEGASGEEPVGELEVILKACRDRGGEMARRLHRERTERMEYLVGRVQDMEAIPEWGEAETAEWTRTSEELKRAVEERARLLRIRAHVPEIASEERLSRPVYAKLAARNSDSKITALRLSNGELTHDIDVALDHTQAHFQRLYHIEPRDPDRVDRLRDEFLAPIRAARTCDDPRSDPLFLRRLSESQIDLLQRPITEDEVVAAIGTTHPGRSPGPSGVPYELYQTAPKAWAKVLTKAYNAMIERGSLSPKQGQGLVRLIFKRHKKNADRAELSSYRPITLRECDYKIFTKVYVARLNQILPDLLPPQQHGFVKDRRSADAALHLRLLIEELGARRTEFPAAALLSLDQSSAYDLVEHDWIFAIFDALGAPATFLRVLRMLYSGDSTSARYIINGFLTAPVRLTCGLGQGDPASSSVWDIVFQPFLDALHRRNIALNLSIPALHPYPQSRAITSLAFADDVVVAVAGLGSVNLLDDLALDWRHATNGRLNTDKTVVLPIGRRWDPGQRPLVVKAAGESLEWIGLPFDPSGDTELAYANLIERLEATLEGVQHRWLTHHTRAFYVNRYAIPKILHFLAADIPPPEVVKKLDDMLVDFVRGGNGRTSYGRDIVFTAKLKGGLGVIRMQDVVDAVAARIWDVLLGGSGAIWQGLARAALQRAQSDLDLATDLWPHPSTPIPSDLHPRWRAALGVPKQQDAQVNPRTLTTANLLALPTLLGSLHTPIRGRQTIDAIHIPDYLRLQGYPKVADLYRRELYAGGGFHLWTPPADVLGDNSEYDRRGLPQRLAIAAWYRFTVDRHKNTPLAVAVAAGRLNVPPRIGTSAPLEAILPKPVARFAMEQRLPDPVLPQQASQYKLLNMARPYTIRRIRRVLNAKAFTNTLGLKGPPQPDDLRSFWKAVNSKALTAREREVWFKLILRFTPTRKLQHQQQHDTSPACLVCEAPVDDTDHYFFGCVDSRNVWIAARGVLCDALGCDTIEDAQYTTLQRLFGLPKLKASLRDQEGAGRTIEIFTGLVLEMISSGRWGMQKWGTRMEGVGRRRIILEERLKLRAGGAWGRRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NCK4</accession>
    <name>A0A2X0NCK4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C041g11971 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C041g11971</name>
        <name evidence="25" type="ORF">BQ5605_C041G11971</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000119">
        <property type="protein sequence ID" value="SGZ33504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="416"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="655"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="759"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="665"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGZ33504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1303" mass="142107" checksum="B7D7F91C7F472328" modified="2018-09-12" version="1">MSNPAISTRHATCATREAGRNGSTTSKPNARTDLEHANFQAIALLRRSVSLNIKKQIKDGFDHTPTDVLKMIKKAVAAGTVTDIFIKLQALLDAGPPPSGVDAFEKYQANTIELFNTLSGYNLTFDQVISIRLIHFGKDLYKEYYTQALRQDLDKLPDPIEALQTLQTQAEPTPAHKPVAMVASLTATDRSSSTPSAPCRHCGGPHWNRKCPVKDKKSKASSAPSASLAAAPDISTLVDGPVRGYLTAAMSTLAKPSLILDSGATHHIVNDRACFTNFRKCKPAPLEGITGEAVNSIEGVGSAVVRSFDGSIGQLHHALFVPSAPVSLFSASRANAAGYDINLSRGKATVSVDGSICHTGEITNGLYHMHASLVDVTTLIEQPVNMEVALNADLKCDTCQAGKITHHPFPTVASNRSAQPLDRVHMDLLAFDGAVSLGGAKYALVIVDDYTRYLWAIPMSHKSDTFAAFKSWLAKVERSSSRKLLAVRSDNGGEFLSNEFSSFLEEQGITRQLSIPDTPQQNGVAERANRSITEGVRSMLHQSGLSHALWAEALATYVYVKNRSPHSANSGVTPHTRWHGSKPSAGHLRVFGCRAWKAATTEARSKLDPRGIPLVFVGYDLESKGYRLFDPATRQVFKSRSVTFFEDEFPARREGITAAPAPVAGDDDDDDDDDDEVVVLPDQHANQAPPDQAELPAALRFDAPGPAWQPPVGSRPRNPPARYGALASLRSTPSAFAFSLGKEVTELVADLEAAGIDTSTANRPLSEPEDPFSLPSSDPTTWNEAMRHPHAAAWKAGAIEEFRSMKDDLKVFSVVELSSVPKGATILPSRHVFRTKRDKAGKMVSLKNRIVAQGCAQGPNSFNNTFSPTAKYTSIRTLIAHSASKGHHIIQADVDKAYLHGVLEEEIYMRVPTGIEGYEGKCLRLHRSIYGLKQAGRVWNDTINATLASLGYRRLACDECIYRHEDAGGDHYIALYVDDLLFFGPDLGEIDRVLDQLDTLYGVKRLGPAEWVLGVQVVRHDDGGISLLQRQYLLDVLARFNMSDCNPCKSPMEANLQLSPEPDTDSADNAIYRSMIGSLMYAVVATRPDLAHSVGYLSRFVGKAGDTHLEAAKRVLRYIKGSLDLGIHYTRTSAPLLGYEGYSDSDWGSDIQTSRSTMGYLFKLAGGAISWSSRLQPRVACSSTEAEYLGLSHAAKEAVFLRSLLTELGLDTSSPLRLLGDNQGAIALTQNPVFHARTKHLRMLEHFVREHVRNGEISVTYIPTHDMVADIFTKPLPRVVFQRHCDAIGLRRISGQEQGGVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0ND57</accession>
    <name>A0A2X0ND57_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C021g09364 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C021g09364</name>
        <name evidence="7" type="ORF">BQ5605_C021G09364</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC45 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000083">
        <property type="protein sequence ID" value="SGZ21410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0ND57"/>
    <dbReference type="STRING" id="796604.A0A2X0ND57"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902977">
        <property type="term" value="P:mitotic DNA replication preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003874">
        <property type="entry name" value="CDC45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507">
        <property type="entry name" value="CDC45-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507:SF0">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 45 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02724">
        <property type="entry name" value="CDC45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="201"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="556"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="204"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="559"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="572"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGZ21410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="791" mass="88478" checksum="CC48386407A1B31C" modified="2018-09-12" version="1">MLLLMLTRLLPPPPTRRVSTLTIPPVYIPSTLYPTAYRSIVSRARGASSATTFLLVSPDVDALCAARLLSDLLKTDDVVNTIIPVGSWSDLEHVRERLLGETVRSLVLLNLGALVDLYDYFEEFLPDTCLVHVIDSHRPINLANLFRTTTYASALFDLRRSRGKARLDGNLPPPEFNIVVWSDAENDDSREGEKEAWEALLYEPESDSDSDDDDDSDDEYARNRRRNRSGTDSDEDQEEDEDGNRIGKRRRTSQEVSKIETTVVFRYMRLKWRFIPQPQALSKTQRRRFRARIDKYYTAGTFFGQSVAGQVFVLAVLLERADTDAVWLAILGLAHQFSTNAIDRDRYEGYVSLLADEVARLSTNVASLATRSGDALASTGPNDRSIRPSEEIRFCLFRHWNLYDSMYHSGYLGSRMKLWTEKGRKNLSGMLAKMGCPLSESSETYQHMATDLKASLFGKIENLAPEYGLHDLIVPSFVRKSGYRTDISAADAVEALGALLEVATGVRLNFGNAVGGRRGIVLGGHEAARENGGREEWSEGLKSWVGKGEAHGQVVRRMGAGDKENRRPDGAATEEEDEESEMDKKARMEKDWALRNFWLAWDALAVDTILLRSALPLSMALHRAVMDQGGYILEKQSIQSLRAFRFAVIKEGPDLAVFRHPSTLLRLAVWLVDAVRDLVASKTATGKRPKPLPFVLASLNEASDAFLVVGIVGAPEYGDVKKKWVPLVQNPGREHFAEYCRVFHSAFGMAFERAAHASGASTRHNAFEASVIEVRKDDLDKFFKDLAMAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NH86</accession>
    <name>A0A2X0NH86_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C048g12406 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C048g12406</name>
        <name evidence="7" type="ORF">BQ5605_C048G12406</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF5 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000110">
        <property type="protein sequence ID" value="SGZ30552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NH86"/>
    <dbReference type="STRING" id="796604.A0A2X0NH86"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006939">
        <property type="entry name" value="SNF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10019">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04855">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="66"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="119"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="130"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGZ30552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="456" mass="49477" checksum="E83C22F88B4AF6FD" modified="2018-09-12" version="1">MSRPPTSAPLMPQPSNRPVLPPRFTLSSSAAAVPPLTPLANPHEYGTRQALYTTYPARMRLGTSSLMQPSAAPSSNQNGNGNHPSSSSRAVSPPQAGIVLGKRTRAPVNYAEMTGFDLTAAGNGRPSLVASSSSNDLLRASSDGPDPAGASNLPSTTGNNTASTTTSTTNAKAVMWGDGKSYLGTLPPGNLVIVQPAKITRHGAFTEDQLEDQAEQQAVFVPIQIDLEVDTFRIRDSFVWNINEKLITPESFARIFCDDLDIPPSCASEVARQIKEQCGEQMGVAEIPVRAAEDELAEIEKDLRVILHLNVMVGTLHLVDRIEWDLSSSLTPELFASVLVRDISLPSSASPLIATAIYEELHRLKKDCLQMGLIGEEEGGVPRRRGPRPLEGVWRDWNETKDFGPNVEILTLDEMDKKEAERDRALRYVPFCSFLVTWVLGGGGGHEWRVLTSIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NM51</accession>
    <name>A0A2X0NM51_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA-guanosine(34) queuine transglycosylase</fullName>
            <ecNumber evidence="6">2.4.2.64</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C010g05901</name>
        <name evidence="8" type="ORF">BQ5605_C010G05901</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.4.2.64" evidence="6"/>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NM51"/>
    <dbReference type="STRING" id="796604.A0A2X0NM51"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:tRNA-guanosine(34) queuine transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004803">
        <property type="entry name" value="TGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00430">
        <property type="entry name" value="Q_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43530">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43530:SF1">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="tRNA-guanine transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="7">
        <location>
            <begin position="31"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY13587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="426" mass="46883" checksum="E28A3C52BA391775" modified="2018-09-12" version="1">MTEGRAPEAMLKPASASPALHFEILARCSTTRARVSRMTLPHGATLLPTFMPVATQASMKGVTPAQLMALDPPLTLMLNNTYHLSQRPTPEILDLIGGSHTYQGWDRNLLSDSGGFQMVSLVKLSKVEEEGVVFANPYDPTKSSLLTPERSMQIQHSIGTDIMMQLDDVVATLTTGARMEEAMWRSVRWLDRCIAEHERSGRRTKQNLFAIVQGGLDPVLRQKCLDAMLSPERQEKLPGYAIGGLSGGEEKTQFWRIVAQCAAALPKQKPRYLLVCAALGVDMADCVFPTRTARFGVALTFDGPVDVRRQVNATDFSVIDPECTCPTCDKGNGMTKAALSMIAGRETVGAHALTLHNLTYQSTLMHRAREAILEDRFPQYLIDFFARFFKTNDKYPAWAVEALLSVGVDLLSGVPSAGRKEISRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NNX2</accession>
    <name>A0A2X0NNX2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C013g07303 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C013g07303</name>
        <name evidence="10" type="ORF">BQ5605_C013G07303</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NNX2"/>
    <dbReference type="STRING" id="796604.A0A2X0NNX2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF16">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016180900" evidence="8">
        <location>
            <begin position="20"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="77"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY15252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="458" mass="49296" checksum="56B20770B03AD18C" modified="2018-09-12" version="1">MVNFKLLLASALPLTTVLAFPQYAAESRGLNLATFEKIVDDIIKRANIPQLHADARERRRNKRAPTFSESQLVDITGVHAFKAPGASDTRGPCPGLNVLSNHGYFARNGNTNLVESISALVEVFNMGVDTATVLVAYSIAIIGDPIALTWSIGRSPGKSTLLPGILSAPGGIDQSHNNYESDASVTRGDSFLTNGDVWSVQIDKFKALYNLQSDPATADYTRDILVQHRNFTIQQSISTNPNFYFAYVLHLYWLTSSQACTLTKSDPPFRRPWSGLVVATAAHNFVANFFANHSASRPEGYLDQSTLKSFFSIVGDTPETLTWVPGEERIPSNWYKPPTPYTLVDVVAEVVAVILAVPAAGKIGGNTGKVDSFVGVDVANVTGGVLNAQTLLEGNNLFCFAYATARAGIPTILGGLVCTLGQTLGFLDSKLAGILPQLGCPQLDKLNLDAFNQFPGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NSP3</accession>
    <name>A0A2X0NSP3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C010g05845 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C010g05845</name>
        <name evidence="5" type="ORF">BQ5605_C010G05845</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0NSP3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22408">
        <property type="entry name" value="KH-I_Vigilin_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054548">
        <property type="entry name" value="SCP160-like_KH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22952">
        <property type="entry name" value="KH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="298"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="391"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="488"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="641"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="721"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="811"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="903"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="986"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="1061"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="1142"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="1354"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="173"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="327"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="855"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="942"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1257"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="856"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1270"/>
            <end position="1284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY13363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1434" mass="150528" checksum="F970E3EA5F22106E" modified="2018-09-12" version="1">MSSALDGDAFPSLSTQANTNGTAADHGSSTGATATSASASRAQSAPLSAAQLMQQAHASGASSTAQAKPQNDILTEDPFPPEKLIREDPYPSLWVPSAGAGAGAVAGAASADASASSSASPAQTQAAKKALDVSDESAFPSLGGITAAPRAASAASWGGGVGGSVAQRLQAAAANNPLEASRSATTQQPNGGDDNRSAATGAPIATATVQLAQSEIHIQAPSGPGAGRGRGQTFSNAREVEPTTLGEVMKLLMKRNPTVTVEASTVRGTTTFIIKGKGSKADDDVAKVKRDLLARLAKKVSIEIKVPASTRGFIVGAKGRTLKSITDSTGANVQLPNRDTIQDASDANEDHTNDEPEGPDGPLISITISGDSSAVEEARQQVMAIVSERVSKVTTKLDSVPKEFWELLRGSKGSKINAIVESVGATGSVNVSIPRNFERRGVAASSGADADDKAEPAMEKAISINGEREAVAKVVAAIEAEVAELKRSTTTVSIKINKRQHRFLVGATADAILEEAQCSIDLPPAESPDDDITLRGTNENLIRAFGLVMQKANATPIESLDLLTAHAGTHDRKVYASHLARYVLRRSKFRALSDANRVQIFLPRQAAIERGDAQLEIVGQDKEGLAAARQAVIDIVRKLPPAAFAIVEVDSLIHRHIIGKGGKSIKALEEKRGVEVIFPPDGEDRSDILLVSATASSPAAAAEALGAAREEILGLAKDAADIKVETISIPASLHGAVIGKDGTTLNAVIGEDKLVNVRFGSTGLKYAGKANGSSQKEENAVVIRGPSEEVKRVKNELERIAEDARNQEIVNSHIVEFEMDTVHVRHIVGKAGAGVNKLREELGVRIDIEELGGAGAAATSSAAPKKKAGTGSSTRSKITIKGRKENAEEAKRRIQSLVTKIADEVTLTLTIPPSLDRGSLIGKQGAYLKRLEDKYEVRINFPRNNRGDEEDVSSGKSNEVTVRGPKKGADAAKGELVALIAYEQENGNVVTFTVSTKSLPRILGKAGASVNQIRDDTGVQSIDVDQQGDDAPTATISLRGTKSAIKAAQAAIVAIAKEVDDEARFTLEIPRAFHTTLIGSGGSSIRELIVKAGGPTDARASGNTVRFPSQGEADDKVTITAPRAVAEKIRASLEKEVANLKSRVVWGVVVPQSAHASIIGKGASALQEFQRKHGVKVVMPGWKDYAETGEIENAADVADAAQNDTVKIVGPKEAAVAAAAELSKLRPNASSAAVKLTISVPKRHHAQIAQGGRFFRSLPSGTRVTHDGVKPPSSSGKSKKFPTPTGNNTAASARIDDDESAAEAAVQFELLSLHNEEELDDKSEIPWVIESSSQENADKVAAEIRKLLDQSDKATHVGWVTVPRGSMPRIVGRGGSGLDQLRAFGVETEVVGKRDANQLTLVGTPATIEQAHQRIVELAAPRPPRQYRNREDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NTA1</accession>
    <name>A0A2X0NTA1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable cytosolic iron-sulfur protein assembly protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C010g06055</name>
        <name evidence="3" type="synonym">CIA1</name>
        <name evidence="6" type="ORF">BQ5605_C010G06055</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat CIA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NTA1"/>
    <dbReference type="STRING" id="796604.A0A2X0NTA1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03037">
        <property type="entry name" value="ciao1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028608">
        <property type="entry name" value="CIAO1/Cia1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR PROTEIN ASSEMBLY PROTEIN CIAO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920">
        <property type="entry name" value="WD40 PROTEIN CIAO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="9"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="72"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="126"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="242"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="413"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY14088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="466" mass="51001" checksum="A0D905EC5B619E4E" modified="2018-09-12" version="1">MSIQPIATLPGHTDRAWQVSWSPSTPLLASCSSDKSIRFYTYTPPPSTASSLYSSPSSSSSLPRFTFSSSIPSAHPRTIRSLSFSPTGQTLTTASFDSTVGVWSPSTDRDDNEQASTEWETAGDSLEGHESECKSAQWSSDGRLLASCSRDKSVWVWEAVSPTEFECLAVLMEHEQDVKSLAWHPQDEVRSLPREITGRNSPRLQFSASHRLQLLASASYDDTIKLYAADPYDDEWSCVYTLVGHTSTVWAITFSPCGTYLASAGDDRTLKIWQRTPKSSAVEVGQLGEAKREEGGRMGPWSAGGVRIGIKERWEWKLVASWEDGLHSRTIYSLDWNRSGVEETQGGLGRIVTGGGDGVINVLQMMKPSTPEGPPSYKLISSVESSHGVSDVNHVAWCKLSPAKAAATLKKLEGGQDEEDNEEDQEMEGENPSTEEDSRWKGVEDMFASAGDDGLVKVWSVRPTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NTF1</accession>
    <name>A0A2X0NTF1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C010g06105 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C010g06105</name>
        <name evidence="7" type="ORF">BQ5605_C010G06105</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BRX1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NTF1"/>
    <dbReference type="STRING" id="796604.A0A2X0NTF1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026532">
        <property type="entry name" value="BRX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13634">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13634:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BRX1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Brix" evidence="6">
        <location>
            <begin position="37"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="279"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY14215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="312" mass="35114" checksum="B372528E1E967852" modified="2018-09-12" version="1">MAPSAVTKDLKRKRSLAQDDDEAASASTTAAARPYKQRVLVLSSRGISQRQRHLMSDLTAMLPHAKKDAKLDTKHQLALVNELCDLSNCNNALFFEARRKHNDLYLWAAKAPNGPSIRFHVLNIHTMDEMKMTGNCLKGSRPLVVFDQQFDAPDAQPQWKIMKEMLTHARSTKPFVDHVINFSIVDGKIWFRQYQILDNPSADPTLPSTSSTPSTTKATKAAAANGPKMSLNEIGPRFVLTPVKIFEGSFNGACLYENKEFVPSQQAYLGQKLVRASKYRGRKDQEVQRRTRESDLLESRPEKPLETRSVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NU92</accession>
    <name>A0A2X0NU92_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C018g08571 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C018g08571</name>
        <name evidence="3" type="ORF">BQ5605_C018G08571</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY25025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NU92"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="792"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="799"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY25025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="811" mass="91841" checksum="CE7032DBC396AF0E" modified="2018-09-12" version="1">MMNVFYKKKNEPSLTLLLEKLRSLGTDVFPEGALLSLDQQSAYDRVDHAWIFDVFEAFGFGERFISLLRALYDPETLGVRYLINGFPTELVRLLCGLGQGDPLSCPVWNITFQPFLDALVRRGIALDLQKVWPGGPRAQLTHLAFADDAVVVVESPAALSKLETLSQTWYEATNGKTNTDKTLVLPLGPNWLRDETAQALPTVQEGESFKWCGYAFFRHGDSKLFWTHVLDRIKAKARAARDRTLSPSGRVFYANAHITSTVLHVLSFDIPPQWFIQAAETALTDFVWGGPRRNTVAREFVFQAREDGGLGLISIGDIVHSVALRFWDAVAGSDEAIWAPLARESWRSLVAATRDFSPWGFFSSTARVEKLYRDSARWGAVVAAARLTLPTIKSELLTLPELLSLPPRLPSLYAEGAKHAYDDADAVAKFAQIADLYWRDEGKGWALVGHRRGFWQHSKEPALRHEHVWARVGQKLKAKALLPKTAVRPARIPLKEDPHPRCFNFFGLTRPFTIRKLRRLVNTVRFPGKDGQDRALPGGQPQEPRVKRFPEGTSQSGRQRFWSWLHDRFASAAEQDTHWRLMYDVTPTRKKQHVQGHASSPSCLFCGNDAAVIETVSHYFFGCAYSASYWSGVLRILFDKLGIADTDVDPSTFTQEQLTMGLPLLRGRGRTTSKWMWVRLACAIGFQRLHLLRWHVHQRFEKDRVVAPPSIPSALRAFKRDFLSRAGFVPGARDWEWQSLFLDVGSASRPPSPFPSKPLDGSRRMEWSLRRGSGRRLVRFIGSFFARLPTAQQPALETQPRRDIRRCRGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NUT4</accession>
    <name>A0A2X0NUT4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C010g06196 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C010g06196</name>
        <name evidence="3" type="ORF">BQ5605_C010G06196</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0NUT4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035361">
        <property type="term" value="C:Cul8-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990683">
        <property type="term" value="P:DNA double-strand break attachment to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18436">
        <property type="entry name" value="BRCT_BRC1_like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18432">
        <property type="entry name" value="BRCT_PAXIP1_rpt6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053036">
        <property type="entry name" value="CellCycle_DNARepair_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47667">
        <property type="entry name" value="REGULATOR OF TY1 TRANSPOSITION PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47667:SF1">
        <property type="entry name" value="REGULATOR OF TY1 TRANSPOSITION PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16770">
        <property type="entry name" value="RTT107_BRCT_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="172"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="569"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="1163"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="699"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="936"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="703"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="748"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="836"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="884"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1001"/>
            <end position="1010"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY14476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1317" mass="143253" checksum="8D749A6BDA648167" modified="2018-09-12" version="1">MSHSTVETGATNATTSTSSGTSAPGVDTRLFSGVRFRLNSSLRKEVRKQVEYCVLSQLLVSNGATEVPAENELQDPTLDSDSREQAVDHSLTHWITDTLDIAEYAQLRPNEDSSNALALPAPRAAAVVNNASGGTGKMKNQVDEQVKIVTPYWVTRSYDLQQLQQPRHYSADPLLIFSGLCVCCDGLPETDAQSIAAGVQSLGGQSRRELTREVTHLLLMSPEGVKYEAWLKHGAAVGMVALLPHWFEDCFKLRQLIPHDIYAFPDPPYINLRTIDSAKSYDERLFDLVKTSASTNGRSQTISVEQMSATKRLELAFSRLSDNEPYQRTALIELDRSHVGGTIALSEPGVRARIGAATTVGSSSTLGGTTSRSTVATLNGSWPPVAGLATSTDASLFSGHRVYLASDLGLRPGLEEAIQNRIIEAGGRCWSFGLDGGKSGTGKNSLLTSTEERKGSIPEEGTNDASVAISKRDRTDEWDRRREAERELHSSTIVITRTRQGWEWWLAYEAGLSTFSSVDSSPKKVEQRRHKIIGNLAWVYHVLAVGKLDPPSSRILHFPLPSLEGVPELRGQLCTISNYSGSARDYVRAMIEALGATFDGAMCKQTKFVITASEFGNKVKHARQWGIPLVTHTWLEACLAKWAFINPALSTTYLVEGTSPAIAFPQMVGEARLSKANIEDWVQRDEVKVLREEALSSGLSMREEEEGMGMEGDEEGWGGKGERGDVVMEDGQTKSPSSPKSRKRIDTKSIVTKSKTTKGKQVVVTNNEDSSEEETTTKVAPKKKMNKTAVQAPAIKRKRSSSGLTSLSPEPEPKVVVVEEEEQAPASVTKATTSGKKGDAPAKSKNADPATPAAKVQAGRGRSDKSSTRKGKKKADSDEDDDGSSSSSSDSGPEPSFTKTFGQIDPANMIVGGSRRAAAGKAAQLLAQQMPDAIRFAKEQKSADKKKKVVTTPGPAGTATKRGSMGPLGSAKREDGESQDEDEVMKRRDDDEKDEAPAPKPKAKPAKKRKPNEVSEPKDDEDEEHVPNGGQAKKRAKTVAATAPKGGRLAATMATDATTSGQISSFDAPPRGKPALKNGGRKLMLMSTGLGLDAKSPEIKSLKPLGITWTDNPSLVTHLVVRAMQRTEKFLCCEDSSFSQSLYCVYFTHRIGVPCAGLGVAPKIVTKEWIDASLKANELVDEEPYLLKDTVREREYKDTLVEILKRARTKQLFEDYTVYITPGTQPEPKTMQRICQSGGATVSLARLTPPIINKIVENRERTIVVSCPGDRREWEALARKKLPIFSVEAVFNSVMHQTLVGFDTASNNRIDGLQLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NVD3</accession>
    <name>A0A2X0NVD3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C012g06900 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C012g06900</name>
        <name evidence="3" type="ORF">BQ5605_C012G06900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NVD3"/>
    <dbReference type="STRING" id="796604.A0A2X0NVD3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="749"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="818"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="903"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1039"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="950"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1039"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1061"/>
            <end position="1099"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY16543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1099" mass="114914" checksum="6436D8032228CF94" modified="2018-09-12" version="1">MLVVQRRAQGMGEPIASLSASPRAFTSAHAIKVVASQLTTRAAAVRSAHLRATTRATRPIATRAVRGQAVFTTKVASGPVKAVVSTSAKSDASAFPNPKAGGGHFVSAQPSIVRSAPRSRTTLAVKTRSVETGFSTPSKSPVKVVKPADAATSGEEASASTRAAATSAAATRPRAATATARNVDPQGNPVRPENSATTTERVFGSNASATKIAAVITTRATAQIQAIASSTAPATTQIANSPFANSPPVAVAQTQAAAQSNENTPSILYASLAATSSEHIFNGGPSTQIAAVSQAAATTAAVAGASSGAAQGSPVPISVVGGVSVSESAQASATVAGGSAPAASSSATGSGSSTGTNKVGSGVGLFRNLPRSTSLALTVLLVFALLGLLGCCCGCFIMRRRRRRSRGNQLGSESGSIREKWNEKYPSARELNDNEVGNPFGDGVRVEDDGEDDDSIQPEALWRRRLNRLNNSSGWDSANPQIQAPQSIATADMTERRGSFSTWTSFDGVGTFDEESEMRAGSLRQRQASHDMSISGYSIDPPSVVFAGEQAQQAQRYGQHFGLAAARHPLAMSFIPLTPSQYSEHSADMTPTGSPSSLHPFTPTSRTREALPDFDLVTLSSNSPPVPASSIRPPTTPGAWRSSLDKIMGSAIEFLTGEFDSRRGSYGSLDDRYTSFMAPRRAPPTPKMSGAGLARANTISVPPKAAATMGMFGPTDRSVHRRFSCDSIDSNPTDAVEVMTARHLGSAKGVRTSLQSVGAPRASSDTESIKPSRTGLGLPESIVPIDATSYKVSSTSSRPLAPTQILVTAPSPEMPVRPYAGFAPIDDPENVSPTSSPRVNASPKAFSPSSPNPAENPFAEHNAFILDPPSPPRERSNAFTPSATRPIFSLVSLFSTRAMVPPSPIVEEDEGSSTSGSPSSLLHGRAIESDGNESSNSEESHTPTIRARRSSASYRNVPQALTNKANRRHSLTGLPIDLLPSSEQRRSSASSQSTLRTGPTEPISKALSVRRLSLGVAAPSRPSSVAIRRSASVDITAARASVVADEESSAASSEGSDEGIDELRLTQQQKEKRFEQMERTRSLMAERRRRSEGELVPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-10-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NXH5</accession>
    <name>A0A2X0NXH5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C014g07590 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C014g07590</name>
        <name evidence="1" type="ORF">BQ5605_C014G07590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY19209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NXH5"/>
    <dbReference type="STRING" id="796604.A0A2X0NXH5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016857">
        <property type="term" value="F:racemase and epimerase activity, acting on carbohydrates and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008000">
        <property type="entry name" value="Rham/fucose_mutarotase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34389">
        <property type="entry name" value="L-RHAMNOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34389:SF2">
        <property type="entry name" value="L-RHAMNOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05336">
        <property type="entry name" value="rhaM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY19209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="119" mass="13808" checksum="C94A388B0B8131A7" modified="2018-09-12" version="1">MAPKRVCQIIRIKPDRLDEYVHLHANAWPGVLETLEQAHFKNYTIHHYAENNLLIAHFTYVGDDWEGDCQKIAENEETRRWWALTDGMQESLVEGATGSGGEKGWWVDLPEVFHFEGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NYD6</accession>
    <name>A0A2X0NYD6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C017g08472 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C017g08472</name>
        <name evidence="25" type="ORF">BQ5605_C017G08472</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY20109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="510"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="257"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="785"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="267"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGY20109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1473" mass="163632" checksum="F204FE2D02DC792A" modified="2018-09-12" version="1">MSPSETIAQESGEIKIAKLGKDNYELWSIRVEAYLESKGYASVLEHGHVRPSDVSLAEWRTMHGLDASVTDTQVVVNLQKKDRSARALIIQCIDDANLKMVKSKTLSAKDIWDKLRQHHEGNAKPFKIRTLLMELSNAKYDEDENMGEFLKSMIDKADQLDDLGQKFGDEAMIAYILQALPPSYEMLKQAIRLGENRSVDHVINRLTDEYTERKLSGKFDKLLKNAGALAVQSTQASRDPNCVCRGCKGKGHFAMDPECPKYDAKKNHGRARNRNKKKKQDSKESADSNELAEFVLTVKSLDESHSLQDNVANRVSQVNQGEIWILDTGASQHYVGDASLLSNRQSGNLKVQTASGQVVHCDTYGMVRFNLKSGASLSLANVYHLPGAPVNLISTRALFKSGAKCGWEDGKDVMTITYQGVILAKTLSGTGYALDFTRIVEDQAHVATRATVGAPLMEWHRRYGHVPVSSIMELVKSGAVEGLVLTDEKVHDCEPCISSKSRASKFSELATQVTDVLQRVFMDIGFVAEDQVDFQGRKAYLAIVDQYSTAKWTFSLKTKSAEEVTRVWIAFRQGVEKMTGRKIKRVRTDNGTEFTNKLIGADFQSQGILHETSAPYTPQQNGTVERFNGSLMAIVRAVLAASKLSWKYWSYALAYATFVANRILHAKLEGKTAYEVFYGKKPKVSHFRPFGSTVYAQVPKSKRSKLELTSVKGIFIGYDSEYNYRVLVDPDSDHKVIVTRDISVLEHKSEQVGVPEVTTLPVGPDEEKGPVDNDKIVVDELQDQVDGEQMPPARQNRPRWEYGDPAVKGRNPGRYEEIDANNEIPHRTRSQRRDAEQQVMYGSAMSVSLPPVPSNYEEAMASPEADKWIAAIKAELDAMARHQVLIDSDLPSGARALGSKWVFTRKENAQGEVTRYKARLVAQGFAQRPGIDYNETFAPVARPSTILSLVGTAAAQGLFLEQFDFDSAFLNGTMTEMVYMKYPKGWDRPQTGQALRLVKSMYGTKQAPREWNAAVNSLMVERGYKRSDADSCLYVKRVDEKFIYIALYVDDGMVASNDQEFLDSENEAFNKVYKLKRLGPVKLFLGLEFERTSDYIFVHQSKYIRDLVAMYGGGSVSKHPVKVPMEPRSDVEHSTDPFDDVALYQSAVGALQYAAHRARPDIVTSVRAAASKVSAPTQADWIAVKRIIRYLQGTVDWGLKFNHGGSTVFELYSDASWGDDMSTGKSIGAFVSILAGAAISWQSKQQSMVATSTTEAEILAASAAAKEAMWLRRLAADLELEQPKATLIWEDNQAVIAIALNPAHHGRTKHYNVHHFYIRERVTAGDIRIKYCKTGAMTADILTKPLARNLFELHREGMGMVGAGARVLCGGPAEAAGCLHEIASFWPSCFSLFSTTHSISHLAYVKLVKGQRSRGTCGIGKLARAWRGAGWRQMAHPSYVMPEDSLGTPQAAEETETSVGEVVIPFRTDLGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NYQ2</accession>
    <name>A0A2X0NYQ2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C016g08060 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C016g08060</name>
        <name evidence="2" type="ORF">BQ5605_C016G08060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY20460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NYQ2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016062795" evidence="1">
        <location>
            <begin position="21"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY20460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="223" mass="25109" checksum="1583BBA772E79AD5" modified="2018-09-12" version="1">MRASVILPLCLGLLSYCANAAPSLEPPFTYQIPSPERIAELAQPYLINPENYSKTVYYRHEPRDHISSYVMYAFQSMTNTSKWASAVVRHTYGHPKKDSNFEPTTTDIALSMPHIIPAPIPEGTPEGEGQPVQVEYVRNRNVYRKVFLWHQPRSAVRGTSDCCDVELRCVSSPAFERFSQVLGLEEKLQLGTLIDLGNIDPTTQPVMREYSEDMAKELGEGCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-05-29" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NYS4</accession>
    <name>A0A2X0NYS4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C003g02406 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C003g02406</name>
        <name evidence="3" type="ORF">BQ5605_C003G02406</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY40651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NYS4"/>
    <dbReference type="STRING" id="796604.A0A2X0NYS4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043904">
        <property type="entry name" value="PhoD_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689:SF1">
        <property type="entry name" value="PHOD-LIKE PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19050">
        <property type="entry name" value="PhoD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="218"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="494"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY40651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="682" mass="76770" checksum="2C7FA29504E3B3B3" modified="2018-09-12" version="1">MPVAKAKAAFLRGKLGGINAVQPMQDGQQNEQSALPAAHEYNEELHDQHPEASSAYAMPGYKPPTHATAAELPGPGTLAQPAPLPESNAKRRMLPHLQMMTGPMLRYDTVKDGIYHAFLMIVVAASNSDTAPIPPCLLLEWDASAQHIGFEHQFEHLTLSEQEKEEKVNRRAVAGLKIFTYYGLNGANDFWRFKIEVPLSDREEEIFYSINKGPENSFFVPARNQNMRWVGHSCNGFSSGVDTAAFNGPDPLWRDVLRKHEEKPLHVLIGGGDQLYCDPLTMEPEIAPWINEPDPEKKRKAPLTEDIRLALDRFFFNKYCSWFRSGAFGQAIARIPMLNICDDHDIIDGFGSYDDATQACPIFSTIGARGMFWFLLFQQFIVDEIDGLPTTFGQHPSKSTIIGGPGAWIPTPSHSFLSYLGPQVYICLLDCRSERKKDQICSRLTYDRVFAELRALPDEVDHLVMLLGVPILYPRMGLIEKTLESKWNPMTLAAKMGLMPSAVNKFNKDAELLDDLNDHWCASLHKNERNWFIEELQKSQLDRRMRVTFLSGDVHATCVSKLFTHSKKIEPRVDPRYMLQIVSSAIVNTPPPPPVITMVSTFGKKKHKTLHHADTDEELIPIFETDTDDSKLKQNTVMGRRNYVLVDHHLESGELGWLIQVEVKQGSGTTKAYGIQAPPPGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P0A6</accession>
    <name>A0A2X0P0A6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">H/ACA ribonucleoprotein complex subunit NOP10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Nucleolar protein 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Nucleolar protein family A member 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">snoRNP protein NOP10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C001g00521</name>
        <name evidence="11" type="ORF">BQ5605_C001G00521</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP10 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY47323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P0A6"/>
    <dbReference type="STRING" id="796604.A0A2X0P0A6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904874">
        <property type="term" value="P:positive regulation of telomerase RNA localization to Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.40:FF:000002">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.40">
        <property type="entry name" value="H/ACA ribonucleoprotein complex, subunit Nop10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007264">
        <property type="entry name" value="H/ACA_rnp_Nop10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036756">
        <property type="entry name" value="H/ACA_rnp_Nop10_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04135">
        <property type="entry name" value="Nop10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144210">
        <property type="entry name" value="Nop10-like SnoRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY47323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="61" mass="6934" checksum="D3A9FEA052D05A1D" modified="2018-09-12" version="1">MYSLNADGTRLYSLKKTTADGKMTKSAHPARFSPDDKFSRHRVTIKRRFGILLTQLPAKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P0M6</accession>
    <name>A0A2X0P0M6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C088g13030 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C088g13030</name>
        <name evidence="2" type="ORF">BQ5605_C088G13030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000031">
        <property type="protein sequence ID" value="SGY27957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P0M6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY27957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="482" mass="51369" checksum="D9812BF2A58A4A29" modified="2018-09-12" version="1">MQTGDPGSAPGARAPPPPASAPTSLPIAGTKETQATQVAGRTATYAAATNSSVVSNETPAQQQDRLARLQALPGILAAIQAVPKFPFFSALNATRNIINPFANALEVSLSHKSTGRASATDKGELVACVRTLLSPNTPICFDTGVPLSGDLEAFMPRITGLQHSSTFRTGVLHHRITVGFVSAEARDAALASAPMLVWNSANARFAKAHPFHRNMLEMRINVGVVRPPSKEQIVAAFQSIVQQLSTKGHSCQLVQVLRVIHVDTAKAYAHTVGDFSAFIHFDDASLFQHPTTTLKEILPSRMDLPTRGLDVTAVRHDYEKEAPCARCHFAGHVERCPLMQAANRKEAEDLARHAVMRGAGMVGGGEQTGVGRAATTTTNNIRPTANNNNTSEVVAPSRALGTDQLESRNRFAGLEERGEEKEQVKEGDEDTGAKADDEDSDSDGNAGAGIDKAGGDGKDDERRRRRQGRTGRQLGGKRTKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P131</accession>
    <name>A0A2X0P131_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C002g01069</name>
        <name evidence="7" type="ORF">BQ5605_C002G01069</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY29609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P131"/>
    <dbReference type="STRING" id="796604.A0A2X0P131"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001921">
        <property type="entry name" value="Ribosomal_eL8_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00882">
        <property type="entry name" value="RIBOSOMALL7A"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="6">
        <location>
            <begin position="150"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY29609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="288" mass="31695" checksum="905023491481C5F8" modified="2018-09-12" version="1">MEPPEMSVRPLGETRSSPFASRSPKATKSGKKPAPAPYPGAKAAVSKKNPLFERKPKNFGIGQSVKHTTDLTRFVKWPEYVRLQRQKVILNQRLKCPPAIAQFQNVLDKNTATQLFRLLNKYKGETKQEKKVRLEQKAADLADGKKSDESKKPFFVKSGLNHVVGLVEAKKASLVIIADDVDPIELIVFLPALCRKMGIPYVIVKGKARLGAVVGRKTSAVLAFGEVKSEDKAELAKLVSAIKANYTDKHEKTKHQWGGGIRGTKSYAKLQGRAKALGQDPSKVSKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P1V4</accession>
    <name>A0A2X0P1V4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C002g01538 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C002g01538</name>
        <name evidence="1" type="ORF">BQ5605_C002G01538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY33746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P1V4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY33746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="208" mass="21966" checksum="B5EB4DD4072BD219" modified="2018-09-12" version="1">MTHQGIQVLTFIPDGCTWSHRASVDVLYNGRGTSCYTAQSVACVAWAGGRGLGASAAAFSGQAEFQKAKRRRQRAGAGTRCPLSLVARTTGVTTSPDHVLVDPTSGRDCADVLTRSYDGRQQSLQRWRSGSVLAAGRAGACAGIDFVHCFSASRLIGNLARPRTTNKDGLESCLSLRASIDDTPTECKCSTPPAVTETLAPPPDVIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P2I5</accession>
    <name>A0A2X0P2I5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01798 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01798</name>
        <name evidence="2" type="ORF">BQ5605_C002G01798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY35750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P2I5"/>
    <dbReference type="STRING" id="796604.A0A2X0P2I5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004487">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF3">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="1">
        <location>
            <begin position="14"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY35750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="401" mass="43457" checksum="7210665D0600BDE7" modified="2018-09-12" version="1">MSIEVPTTLCATVTGEAVAKPFRAAIIATTSTSSPRPKLVGLLANSNAPSRAYAEWTAKACQAVGINYELREVGAIKKGQDHAVAEQGEVEEAILEANADDEVHGIMVYYPIFGPRQDGYLQQAVSPLKDVEGLNFTCPHLHYIRLFSLYHNTRFIDPRKIALAAQVVSPPAASTSGSGPAEPELVKAILPCTPLAIVKTLEHCQVYNPVLPYGSRAFGKTITVINRSEVVGRPLAALLANDGARVFSVDLDGIQEFTRRRTSAPAAEGEKPRPSFQPRHFVQSTPLKLEDCLAISDVVVSGVPSAAYKISTDALKEGVIAVNFSESKNFETNIKEKVRPATQLRILLSCRALMHNPQNFIAKASIYCPGIGKATIVLLQRNLLRLREYQDILKGIASSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P7R4</accession>
    <name>A0A2X0P7R4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lysophospholipase</fullName>
            <ecNumber evidence="6">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C006g03842</name>
        <name evidence="9" type="ORF">BQ5605_C006G03842</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the lysophospholipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="6"/>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY54112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P7R4"/>
    <dbReference type="STRING" id="796604.A0A2X0P7R4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF40">
        <property type="entry name" value="PATATIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 5 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLA2c" evidence="8">
        <location>
            <begin position="142"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY54112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="809" mass="89983" checksum="DAD7A7F61FAF5D83" modified="2018-09-12" version="1">MDPYLSLGGSTSSTGPTSTDLERTPHGFSVCKRLGSRVWLVWAFWVCKGNYYRGKKKKDGTREAETCGVRLMGEGRGSEEREVSLSFEEKGGSLPAEKGVSFPIEAMGYSPSNYASHKTRKASHGAKQMLQSDIEQDPSLSPHRNETAHLRRNSSLSAEEMTFLTERKRRSHRVRGWLSFWDWRKGKRSMNETSQYLEHYQIGLGGSGGGMRANLGFLSTILAFQELDLWPLLTYTAGASGSCWALASLYTLPIAHPLMSSLNAAAVIEHFMSVSGDHPLSTKSVIRVRDAHGGYQSLFGPLITKSKNGQKICMIDLYSALISSYFWMMPRKDGKDQVDPYVPCVGSASMKWSRAYDNAGLAHGHKPPWRSWKDPNVSPHTIDEEIAERKKRDAWWQWFEMNPVVVGCHELQGWVPTWSFGRKFEKGLSVQNLPEHSLALLLGSATAAPAAPLSSFLEMLWTKLPRDVFGSALIHTLLTLSRRMGDSIMAKLDNINPIHASNEANPFFDAPKRSGRGNGFEHSPRLHLVNSGMSNNCPTHVFLHPARDVDLIILSKGSALARINEYGAKKGLEFTPRQRLPPLMPPKMDKAGKVLPRSIDEIRFKFEGTYAQFLDGKALHVVEGAQSSLFRSNIAIQSLNSSLQILGREGVIYNEKHQPQAWRDVTLVYLPLLPNVCNPEHDPSTAPFSSSYNLIWTAENVQDIVKTATQNVSCTRVSHNIDVGLTRALIRQIRDGKVILNQAISEVYAKRKALRLAGESLPVERARCNIANEDEVGRVVITGKNPLEVALDASEMRGKRPWITPAGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P8V8</accession>
    <name>A0A2X0P8V8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g04211 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g04211</name>
        <name evidence="1" type="ORF">BQ5605_C006G04211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY57025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P8V8"/>
    <dbReference type="STRING" id="796604.A0A2X0P8V8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY57025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="614" mass="68571" checksum="A19F791B07BFA3C5" modified="2018-09-12" version="1">MQLLSRFFRKRSADNTDAKMKQLAKLSGARLQQAKTAVRILIDLWHFFDRIYVSKKHGAAKAFAHAFSDAVFIPNADDRLLMEARLAKLGMTWEEAVRSPVWNKKFWRRVFEKFGPLIDAKLKQPLFNKAAHEAAKRCPEAIRKGQVSDPVGIKLYTDLGPCGGPDGKADDGVRLYSCQRGTNSLEGGIHRNLCQRFPKSGVSPCHANACLADYVLVHNLMVSPTSPSRFEEAATFLTHYPLYSQVGTFNRTGKPFVGHYDLWLTVELHCLRRKTSAFLPRHSTTVSDIVNPLLYTPSTETFGIVPVQSPTAQMRFLIEPYHVERGTLRLEPVKWSPRNLLQNNTSAIQHMQSRLLTDRKLRHDWLAERQGTRFAVLHVHTPSERALYRYLSSKIRLGAPQNLRILEITELWNKYANGVDIFYNMPEHINTWASRWSSLANAQATMNMGGNGVRVIQALLTDPSRGRDVSMLVAKPLLGHKPPVLGRLTEIEVDAPDPPTSSIRPFVATASSDAGSSADLGTSSALTRAGTTKGARHCRFCGQTTCRLKGSKLSDDGSVTGCEGACLDCGKPFGLTDEMDPNDSQSQRFCRGLTRAEMNSRAWHQKKCHNFIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PAN0</accession>
    <name>A0A2X0PAN0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C004g02595 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C004g02595</name>
        <name evidence="5" type="ORF">BQ5605_C004G02595</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY65782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PAN0"/>
    <dbReference type="STRING" id="796604.A0A2X0PAN0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF8">
        <property type="entry name" value="BENZIL REDUCTASE ((S)-BENZOIN FORMING) IRC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY65782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="273" mass="29454" checksum="2D75AC19721C3B30" modified="2018-09-12" version="1">MLVRRWLQRPWTCCLARKTNKTSCIVPREILLKNGYNVVALQRSETPELVKLADTYSGSLVISKGDVAKDEDNKAAVDVAMQMFSRLDGLILNAGTLSPLGKISSMAGRLAEHKALFDTNYFSLVSLISHALPFLNERANKDLQEGEEISGRIVMVSSGASTGGVAGWGAYSASKAAMNSLARTLGNEELHISTLAVRPGVVDTEMQASLRATGEQHMSAKHFSKFTGLHERGELVPPEKPGAVLAGLAIKATKELSGSFVSWDAEEMKGYAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PC37</accession>
    <name>A0A2X0PC37_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C004g03135 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C004g03135</name>
        <name evidence="25" type="ORF">BQ5605_C004G03135</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY70301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="592"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="42"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="847"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="23">
        <location>
            <begin position="889"/>
            <end position="901"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGY70301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1499" mass="165355" checksum="4D3532050BFB5834" modified="2018-09-12" version="1">MTLGPFAFASRRASQCSRLYRSLVIFVTTLLVMSHTDLPANIALPDSDDENSMAGNNETGTPPPPPLPLSSQPNIVVPPMHVLLTREQFDDLVKKRRSVDDDDVSKRNLLPPTSPPAFPDESKLSDNNYVDWDLTMSLTVPREVCLYLRTGCHNKAWLPELHSRWEDYAARVLAGSLTTVAKGMIGPVAQKGGNAHACWVALTKRYAPSDAQSHSTLIRDFFNMPKLPSTWAGFNKWTNRAMVLINHLRMAQLDLEQVISARMIDDLPPLYNSWRTTFYLLQPNKSKLPVVEEIFASMELVARTLRNKSTPALVAQTPSLATKAGQNRKGRWDRSGPPPGNCPACQQGKHWVEKCPDITRRNKYLKLKAALEEFKGVSPPSAPALAANDDNAYMAFFAAPAFVNLSKSANLLLDSASAYHVFNDSSFFNGPISPASHVMQGLGGTVNASGIGSVKLITDSRTKLILNDAIYVPESPANLISVWAFDQKGVRITVQKGHIELSTAKGCIATATAIDKGAPPAYVTTASTRPPLLTLHCRYGHAPIQAIKRLVASGQVKGLDWTYSDSECVEFTCNACLASKAHRSPFPSSLSHTAEPLALVHSDVLSFPEESINHFHYLVTFIDDYSRKTWVYPISHKSDVLPTFKDWLLEIENATGHRLKTLRSDNGGEYISSAFNGYCAARGIHRKLTIPYTPEQNGRAECANRSIVEGTLALLSHSGLPRLCWDEAAVCYIHTKNLSSHAALKGGVPNHRWSGTAPLVTALRAFGCRAWATVPGHRRNKLDPKGIPLVFVGYDCHAKAYWLLDPTSMRVSLSRDIKFVETKFPFLSMPKRATAPSIPGYRPIAQPMLQPEGPRATPNQLLPPNDELPAPDDKAASVRSDATNAAEVLPPPEQVPEPPAKVKPAWEYSDLARVGPDPGKYGEVDPRNIIEGPRTRRQLVPTMIAKEQLDSGPNGPTNAFKNLILAFAATTEGFAEHDLAMVRDPANWGDVIRTGQEEVWHPPARNEFNSLLNKYEVFEIIESCDLPSGEILLRSGWVFRTKQNQHGDITDHKARLVAHGCSQRPGLDFEKNYAPVVKFTSICALIALAAANGYHVHQANVNKAYLHGKLDKPLYMRVPQGINLPGKILKLSKSIYGLCQAGTIWNAEIDSTLRSLGYIPTKSDICIYRRDHDGHSHYIALYVDDLLLVGPSVAEINRVLDALELIYRIKRLGPAEYILGIQVKRGQDGSITLSQERYLCDLLDKFRLGNAKPASIPMQPGVVLDFQDSSATPQDRTRYLQAIGSLMYAAVGTRPNIAYVVAYLARFSQQPSPAHWTAITQVLRYIKGTLDLGLTYRKNNVTFHGYSDANWGACLTTSRSTMGYAFIYSGAAIAWCSKREHRVAKSTTDAKYLSLSYASGDAIHFSELLAKLGHPVLGPVVIYGDNQGSLALAQHPTNHHGSRHVRISKHYVRKRVAEKEIDVVYIATADMFANIFTKALGPKPFLFHRENLGLRGTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PFI2</accession>
    <name>A0A2X0PFI2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C009g05820 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C009g05820</name>
        <name evidence="4" type="ORF">BQ5605_C009G05820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY86474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PFI2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016130642" evidence="2">
        <location>
            <begin position="23"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="287"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY86474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="413" mass="46288" checksum="063DCFE99A2DD646" modified="2018-09-12" version="1">MAPLWFLSCSSNFLVWSPLVLRSETYHCLSRPDLAYTVGYLARFSHSPSAAAWGAVKHTFRYLAGTLSHGLRYACGNPAPLLGYSDCNWGACVLSSKSTMGYTFVYAGAAVSWSSRLQSRVADSTCDAEYLALSHAGKEAIFLRQLFGELGLSSSKPVLIYGDNQGANALTKNPVFHARTRHIRLREHFVRDMVSMGDIVVQYINTGEMTADIFTKALSRDLFARHRGRLETYHRLRRCVTSNFLVWSPLVLRSETYHRLSRRDNITFNVFKTWLAEVELETGATLKVLRTDNGGEYCSRAFTEFCKARGTRRQYSIPRTPQQNGRAERVNCSIVEGILALLADAHLPKTFWEEAAAYFVYCKNLVQHSALDKATPNSVWQGRRTTASALHPFGCAAWLTVAPELCSKLDPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PHZ7</accession>
    <name>A0A2X0PHZ7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BQ5605_C033g11182 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C033g11182</name>
        <name evidence="11" type="ORF">BQ5605_C033G11182</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WHI5/NRM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000066">
        <property type="protein sequence ID" value="SGZ02046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PHZ7"/>
    <dbReference type="STRING" id="796604.A0A2X0PHZ7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013734">
        <property type="entry name" value="TF_Nrm1/Whi5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40468:SF1">
        <property type="entry name" value="TOPOISOMERASE I DAMAGE AFFECTED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40468">
        <property type="entry name" value="YALI0A15257P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08528">
        <property type="entry name" value="Whi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="385"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="469"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="583"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="676"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="201"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="73"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="398"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="429"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="489"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="527"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="597"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="704"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGZ02046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="729" mass="75741" checksum="086372616B4D75A8" modified="2018-09-12" version="1">MTTMATIATTTFTPFKSSSSDSNLSACQASPTTSLVQQHSHQQQHQQQLPPQPPASQAQHQQQLQQGADTFSSHHASSAASTSSASTSTTTTTTITTTAHTAATKSAKSTPRSSTASNRNRTPSSISSGSSSSAMKRSESAMSSASTSGKEERKRKDAIDKVLQRAEIARITRHFKTRLALAAFKAQRGWQDATLDQIEPHLEQEAQRHKQQQQLQQQQAQKSQQQLQQQQQQHMMAQQQFLAQQEAAAAQQQLQYHRSQPLQGGAAFQAQKPPAHYTNGNGMEYSQPYQQPMPMQQPPQQAWGRPGPFDNAGMGPPSFAGHKRARSINIYDQPQQSMAYPANLGAYGSPQPMASTSALQPPVQIGANGGPAMFGDASRPTKRRVLGQEHGGGRPSLHHSSSSSSSVGSVKALGAITELRSPRSRHSATRSSLSRGNSSASMVGRPVSSSDPNFSTFVDAASVLTGLSRGLSDQSDNSDEGMQGGAAGGPSSSSQSNPFGSSIPRPRTPTSANDKGKGAAMHHMSGVNGSAPPTTGGESSAEGAAELMLYLAYSPSPVQSRSSHVVNNIGGEGMMKGRRLFSGSGEDHPAPSAAFGNGAGMNGAGGGPNGTGLGSYDEALHPAKASRVVSAPPPGSPPSSMLGPGAFGGAIPSTPGRERQISSSWDAYINVSPSPQRVSIARSSEHSYASNGPPPTFLLPNGTPPGSNAPTSTASTTAGGVGAGAAASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PI64</accession>
    <name>A0A2X0PI64_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="23">BQ5605_C030g10765 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">BQ5605_C030g10765</name>
        <name evidence="23" type="ORF">BQ5605_C030G10765</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000069">
        <property type="protein sequence ID" value="SGZ08046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0229">DNA integration</keyword>
    <keyword evidence="18" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="16" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="15" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="16" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="17" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="22">
        <location>
            <begin position="832"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="335"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1092"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="21">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="1155"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="21">
        <location>
            <begin position="1190"/>
            <end position="1207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="SGZ08046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1655" mass="178732" checksum="FD54605A37FB4CB6" modified="2018-09-12" version="1">MDSSPAPPSPPRDPSPPESSISVQITTLQAQLAALQASQPPAVTATQANTATAAKVVFPKHARLDGPKLFTNWLRQLHLALPNQVHGYVLDGVVPATWTADQLAARDDAAREIIVGSINSADVSATLDTIPSDDLSAPRIFTALKACFAPDNATRTLELFARLQIRNAKTLLNDVLTMVPSCLDSFRLTFTDKQRNQRNLPKLTTLTDHICVQLRSAGLSTSHLAMLAVGVFSLPFWAGSVRLTQAAGPAARSPEPTGSALLFLLLKQLLGLVSLVRRSEPYHRLSSRRNFIGYKPIRPTSAATPVSALACRFFFFAPFARPSLARRSARLRMPAADDTDAAGDTNSVGPTTTLAVPPPRPPTQVAAFAASDLLRDANGYQDWVLTLCSRLPSDVLDYLESGVPHPSWPPSYVPLWDHYARASICAAVDPRMVLPGLARYFGDPHSGHKIWVALRTRYGAVSAVDLLPVVSRLFSSEPMPDTSDAFLQFRDRFENDSRLLNDSKVTTDSLLASHLLARMPPSLSAWRTTFVNSQGTSSTLPPAAEILDRIYREIKARPVDSPAVAVAASQQRAPRGPCPNPSCRKMHWLRDCPDTAWAAAFRARKASAVATSRGHKKGSQAVASPAVAEMPEPATFTACLLATPSAFPKLAWLLNSGANRHMANDSKLFSTLRPFTGPHVAGVAGSLPSTGCGSVRLSTPAGPVVATDVLLVPSLPCNLLSVRCLDCLGFSISFGSGCAKISNSSGTVVATAQAVANDLYALDVAPSPCMPNALLATPHRVPLLTLHRRFAHLPIAQLKNVVQNGLVTGVDWVYSGEEVRSFHCNACLASKAHALPFARSESVASGHLDLVHVDVAQMPRASFGGHRYILVIIDDYTRKQWCILLAYKSDVFHRLRDWILEVENATGDRVKTIRSDNGGEFTLCNFVDFCLAKGIRRELTIPYTPQQNGRVERANRTIKEGILALLYSAGADPRLWAEAARYFVHCKNLMPHAGIRGDIPDTCWHGVAPDISSLRAFGCRAWHCLPSVKRTDLDPKAMPLIFVGLDDHAKAYRLFDPVTRKIILSRNVVFRESEFPALQPVADTQTGATPLSVAGNIYPDQVDHSEPLPVAPPRSLAPRAELPGPVPAASDQGLRRPSPARDIPDQDSRAPPASDQGSPTSQAGDHFNQDSPTSCASDQGSSDSATSIPCPSPQPVAPCPLPAPPSPAQSVSADPINLLPRSGDVASICLAQDFPDDLDAALHSPSPVAYLASGAAALLSTSLADPRQAIGSLMYASTGTRPDLAYTVGYLARFSQSPSAAAWGAVKHTFRYLAGTLSHGLRYARGDPAPLVGYSDCNWGACVLSSKSTMGYTFVFAGAAVSWSSRLQSRVADSTCDAEYLALSHAGKEAIFLRQLFGELGLPSSQPVLIYGDNQGANALTKNPVFHARTRHIRLREHFVRDMVSLGDISFVSQPVCSASRSTWCLLSLILEVGGVSLPFWAGSVRLTQAAGPAARSPEPTGSALLFLLLKQLLGLVSLVRRSEPYHRLSSRRNFIVRFPRARLFNSRARAAPSTPGLSNTEHCPSMKYVAYHLKLTVTDCHLQQYQTSWISPPLVFVVQHNTSQPRWRTKSLALCASQCDWPACYNSPARLPDRTVSILCSLMPFFLFSTASHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PIU3</accession>
    <name>A0A2X0PIU3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C028g10508 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C028g10508</name>
        <name evidence="2" type="ORF">BQ5605_C028G10508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000080">
        <property type="protein sequence ID" value="SGZ12476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PIU3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ12476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="292" mass="32301" checksum="7894B72E18C5861A" modified="2018-09-12" version="1">MTMLICDSDTNTGDRGPQELIVQVRSHRCPDGRPKYQVVSSLHPSAMPLRYPTLFAAEENSSHLNTPLCGFHQAGPPIARNREQIDNGVQLREVLPVSVWMTNEEDKDRDDEDEDREEGDEEDGDGERQRSSKGVEVASLAFTILCALLAKGDEYFSIPHCTHGPFLESVIYGYTPSRDRSTLHIRLHQENLHLTTTQGINGLAPNPIGPIPGCDGVRCQTWKASAAHHDDVRPRLTGNQGCTGADKACNRPDLIARVFEAKSGNKRHAGCFGDECKMNGFCFFAVLRVVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PJ26</accession>
    <name>A0A2X0PJ26_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C029g10609 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C029g10609</name>
        <name evidence="1" type="ORF">BQ5605_C029G10609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ14660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PJ26"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ14660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="52" mass="5779" checksum="481ABA1B4410B771" modified="2018-09-12" version="1">MYQHTVVSAAPACGVHVPIRSHVQALWQLLFFSRQSNEATAFPVFSVTFSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PPI4</accession>
    <name>A0A2X0PPI4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C049g12449 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C049g12449</name>
        <name evidence="2" type="ORF">BQ5605_C049G12449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000111">
        <property type="protein sequence ID" value="SGZ30740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PPI4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ30740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="60" mass="6726" checksum="243B66F582DACAB3" modified="2018-09-12" version="1">MRRNSRFTESGDRPLPGPMLMSQVPKKGMALSCSRMHTAASEPARRASRTTKLLPGREQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LQK5</accession>
    <name>A0A2X0LQK5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C010g06140 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C010g06140</name>
        <name evidence="1" type="ORF">BQ5605_C010G06140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LQK5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY14321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="35" mass="3988" checksum="85B8E4350966A57F" modified="2018-09-12" version="1">MPQVVHLFKSFFSYAAGQRSALDPQQLQITKSILH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LSV8</accession>
    <name>A0A2X0LSV8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C090g13050 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C090g13050</name>
        <name evidence="2" type="ORF">BQ5605_C090G13050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000004">
        <property type="protein sequence ID" value="SGY11554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LSV8"/>
    <dbReference type="STRING" id="796604.A0A2X0LSV8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040108">
        <property type="entry name" value="Laa1/Sip1/HEATR5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663:SF0">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663">
        <property type="entry name" value="HYPOTHETICAL HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY11554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="427" mass="46032" checksum="5B6D9BB2378E980E" modified="2018-09-12" version="1">MVVQNALYDPLLRLVSHPSHSVQIAAAWALRTFCDNAPTRLSATIVQLVELLNKDLAVIAQKPNESSGAPGSNKEGGTPSPRRAVGHAHALAALINLIPHQPLYVSFDISAKCMSLAIQLLKQSANHELIVSGVEIHVAWILVSALMSLGPNFVRLHLPQLLILWRNALPKPTSKDASAAQVRGENEWAFLLHIRECTLGAILSFLRHNGGVGRRVSNVNNANGAAGEGSITATGLISDDVGRRLVLLLSNGLSFASSFQLTFEKTLLEQHNGAGDIVALVTVRSRPHAAQEVVAVLRRVGPSSRYRTVASYFVDADRAPLLGSGTLHRRVDASSRRQLTEFTSVWEETDGFGYGVTSLMKDGETLVASPRGGPRRRSKDRQTQSRFSSPSLASSTWEVPSAPPTAIGLVDAGIELFAIYFFDARAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LTZ1</accession>
    <name>A0A2X0LTZ1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C014g07438 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C014g07438</name>
        <name evidence="25" type="ORF">BQ5605_C014G07438</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY18679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="496"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="244"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="771"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGY18679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1765" mass="197922" checksum="EA5AB665D83EF740" modified="2018-09-12" version="1">MSPSETIAQESKEIRIAKLGKDNYELWSIRVEAYLESKGYASVLEHGHVRPSDVSLAEWRTMHGLDALVTDTQVVVNLQKKDRSARALIIQCIDDANLKMVKSKTLSAKDIWDKLRQHHEGNAKPFKIRTLLMELSNAKYDKDKNMGEFLKSMIDKADQLDDLGQKFGDEAMIAYILQALPPSYEMLKQAICLDEYTERKLLGKFDKLLKNAGALAVQSTQASRDPNCVCRGCKGKGHFAMDPECPKYNAKKNHGRVRNRNKKKKQDSKESADSNELAKFALTVKSLDESHSLQDNVTNRVSQVNQGEIWILDTGASQHYVGDTSLLSNCQSGNLKVQTASGQVVHCDTYGMVRFKLKSGASLSLANVYHLPGAPVNLISTRALFKSGAKCGWEDGNNVMTITYQGVILAKTLSGTSYALDFTRIVEDQAHVATRATVGASLMEWHCRYGHVPVSSIMDLIKSGAVEGLVLTDEKVHNCELCISSKSRASKFSELATQVTDVLQRVFMDIGFVAEDQVDFQGRKAYLAIVDQYSTAKWTFPLKTKSAEEVTRVWIAFRQGVEKMTGRKIKRVRTDNGTEFTNKLIGADFQSQGILHETSAPYTPQQNGTVERFNGSLMAIVCAVLAASKLSWKYWSYALAYATFVANRILRAKLEGKTAYEVFYGKKPKVSHFCPFGSTVYAQVPKSKQSKLESTSVKGIFIGYDSEYNYRVLVDPDSDHKVIVTRDISVLEHKSEQVGVPEVTTLPVGPDEEKGPVDNDEIVVDELQDQVDGEQMPPARQNRPRWEYGDPAVKGRNPGRYEEIDANNEIPHRTRSQRRDAEQQVMYGSAMSVSLPPVPSNYEEAMASPEADKWIAAIKAELDAMARHQVLIDSDLPSGAQALRSKWVFTRKENAQGKVTCYKARLVAQGFAQRPGIDYNEMFAPVARPSTILSLVGTATAQGLFLKQFDFDSAFLNGMMTEMVYMKYPKGWDHPQTGQALRLVKSMYGTKQAPQEWNAAVNSLMVERGYKRSDADSCLYVKRADEKFIYITLYVDDGMVASNGQEFLDAEIEVFNKVYKLKRLGPVKLFLGLEFERTSDYIFVHQSKYIRDLVAMYEGGSVSKHPVKVPMEPRSDVEHSTDPFDDVALYQSAVGALQYAAHRARPDIVTSLYSDASWGDDMLTGKSIGVFVSIMAGAANFWQSKQQSMVATLTKEAEILAASTAAKEAMWLWRLAADLELEQPKATLIWENNQAVITIALNPAHHGRTKHYSVHHFYIRERVTAGDIRIKYCKTGAMTADILTKPLARNLFELHREGMGMRRSYNNMMDTRLAMPTLFHPETDGRSERTNKTAIQALQAVVNKQQNNWVRHLVNIEFAINASVNASTNKSPFEVVLGRSPSLLPTSLNRPDLPNVPAAKDLIAEQKAVLAEVRDALATAKVRQAEQVNRHQRPEPDIAVGDFVMVDTRDRRLQFKTGHRKLAKLFDRFEGPYKVIAANVATSNYTLQLSKGDQSHPTFHVSKLHPYRANDPNLFPNQEPARPKPVIVDGHEEWVVREILEETTRGGKRYRVWWEGYPQHETTMELRENLVGTEALRCWELKKRMEGRVLVNYYCLILSIVLEHRYTRCFHSTTDTKYLALSHAGKEGIYLSQLLEELHVQPVTPAHIYTDNKAAAAVAHDPVRVSGTRHIRLREHFVWDMVNWGDTSLSHVGTSDMVADIFTKALGPKVFSTHCYALDLRTQHPRLGSASHLRGGVCVKSPLSARQGRLGCCARALARPPAVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LU14</accession>
    <name>A0A2X0LU14_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C014g07468 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C014g07468</name>
        <name evidence="6" type="ORF">BQ5605_C014G07468</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. TRA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY18766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0LU14"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05163">
        <property type="entry name" value="PIKK_TRRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046807">
        <property type="entry name" value="Tra1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046805">
        <property type="entry name" value="Tra1_ring"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF1">
        <property type="entry name" value="TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20175">
        <property type="entry name" value="Tra1_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20206">
        <property type="entry name" value="Tra1_ring"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAT" evidence="4">
        <location>
            <begin position="2665"/>
            <end position="3223"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="3">
        <location>
            <begin position="3449"/>
            <end position="3776"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="5">
        <location>
            <begin position="3787"/>
            <end position="3819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="576"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="628"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2095"/>
            <end position="2121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="576"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="628"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2108"/>
            <end position="2117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY18766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="3819" mass="426300" checksum="76710A411C477042" modified="2018-09-12" version="1">MASSTSATARRQSTASTSAVAGAAGASTASNLNNGAIPFSSTTITGTASASIHAPALGGSTFGPAAGAALAGQEFEQIAAKLSDPGLDSKHKINIATELRDSVDMYQRDMDVARFFDTLLPCFIDILSHGKPSFAGASTENRLRNLLIQILHRLPHVEPLRSHAPPLMILLLKLLRIENEDNAVLCMKVIIDLHRTYSRGPHPLASGAIPGQDSMPDPTAVKIEASVDEFLGIVADLFKGMGAVVDETFSSETAGSKEASSPAAAAPPTIEGPEGGGAGAVIHAPAMKSFKLLQDCPAAIVFIFQTYRSYVDKAITIFVPLVFDFLQLQAAPQARKHASMEPGKSWVGTCPEISKAKRGAFQDMVLAQTKTMSFLAYMLRVSQSALSSYLNILPDIAVRLMKDCPSEAVAMKRDLVVATRHILQSELRSAFLGQIDTLLDDHVLVGNSVTGYESLRPLAYSMLADLIHHVRSELSLSQLSRIVHTYSANIHDPTLAAAIQTMCSKLLLNLIEPIATKEPSEAIKILQRMLIAFVSKIEALAEVRDEWSKWSKPREPLPHLLARIEKLRDERKESIEASAVSKAAAPTALKGKGKSKGKSKGKEKEAAQIADATDAMNYDDDAAAARAKLEGGDDKEKDDDGAGEDVQIPELDDVDIERSKPMKKAMVMTDPGPDPIKDARFLFRNLLFGFKTITSALIKLEGKGPDAEMMCRFFRASVKCMVLFDSSRDQGREQKEVMEVFSSTLIQIELVILQEVIEHCIGFFFTELIRNHELLVIPQTLLSNEMVSQHFVAILFRFLASRLPDLGKAGKEYKDYMSVTLRLYKMSFMAVTIFPEKNEPVLLPHLSNLIMNSLKLASQAAEPHAYYLLLRALFRSIGGGRFEILYNEVLPLLQGLLEQLNALLKAADKSKKDLFAELILTVPVRLSVLLPYLSFLMRPLVHALRASSELVSQGLRTLELCVDNLTQEFLNPLMAPVIDEVMVGLWELLRPLPFNHQHAHTTMRILGKIGGRNRKGFGPPKLEWKPVGPEALLNVKFEGKDASLHIAPIVNVAVRMLGRGDPYYRRAAYSFLKYAVAIFLRNGLPAGQPEETFGQILKGLFDATRVEEFAVEANDYVFNLARHIFSLELGKELPENPAYAKQVLPLCSALLDGIIENICGVENADLPKAAEQTQLIVEDLIATRDPATTTAASAAAATASANPTTGPPPRLDPATALLHQLGSRLSSLCYDPSWQRKTGAAMGLSILTDKVGLETRWILDHEIEFTRALLFSLKDMPGEAPINHELVSDTLLHIVRVCSGPGARENTPASNNQLNYLVGLLLLELCSQISSVRETVKKALKILSELTSTPLTELLMPVRDRLITPIFTKPLRALGFMMQIGHIDAVTFCITLDPPLIDFDEQLSRLLHEALGIADAEDAALLGGKMTTKTTAPLTQLRVVCVELLSAALSNSEFNKPQHQPTRLKALSVYFKLLYAKAPEVVDAACESLRQVMAQQGKLPKDLLQSGLKPVLVNLADHKKLSVASLQVGLAKGLARLLQLLTNYFKVEIGHKLIDHFKALATPADLQRLSTKQSSDDGVLEIMAAIINIFHLLPHPAANIFIEALVTLVADAERQLKKLKTSVFTVPLTKYLRLYPGEAVQFFFTRLADARFVTTFRAVIASELSEPIRDQITLGVNQLFISSFESEGDVGYHAALVMRELIEIDRTWIVKCSGVLGQLITRWVSDIRRQRLAAEGDAHFQQLREDAVVLDIFIAYLEQAEHIDLLFHVVDAFTFWNSANLTVLTRFLNQHVALSHDVKFKRTILDRFIDIFENPAVAKAHKTAALRMLTNPILLVSSSRGAGENDLIDGDFINKVHAKVWQPLLATVPDLATFEDEALRVELCHMSTLLIKSYSHLVLDNKKDVIKFGWVTIKLEDITVKQAAYVLIASFLERYESPGKIVVQIYVALLKAHQPEARALVREALDILAPSLPKRMGPGVGAGPASVAADSTYWAKWTRKILVEDSGSMALLVNIYQLIVRHPDLFYPTRELFVPHMVASLAKLTLSSTTTSDTRVLTLDVIELILKWEKKRIEAAKLEEMTKMEVDADLTDVVAGSPKRTGKDRAGSTAPSTTSTSDRTGGYAVPAVLRDQVINNLLRFIANSPEAFLRNNYVARALVLLKELVSPNVWNDLHVKLAFFQRTFAGVQTEVPEPMLVTLCNSAEVLNVVSLHKSPDWYISNIATLQLIFDKGYSIVAVPSPSKSVPGQPLGAPSMVINEMRLQTALRPVLERTFDALPRGVGGEGTEATPEVVAFFEWARNMINKHLGTITQMPPTMLVLQAWAKASPECVDEFISLIARACAKYTKDHVVSTSTAPLPGDPTLRLLVSSLELLRQRVSHLGEHRRWLLSSIVQLVEKSNNVELCRFLLQMTRKWVTDHDEPFPTMREKAGILHKMMAYEARGNEPLHRDYLSLILDIYSNPALARSDLTMKLEPAFLMGCRARDPVMRSKFLATFDGSLATSLFSRLHYILGVQSWEPLGDTYWIHQALDLLLGSVDPDEPLFVSSSPKSVLNAMPDATMDTDDSSPPSFVEVLSCYTSGMLLGAARKILYADPQATHALWISTFKTSWACLNRREHLDLTRLIVSLITKEYHLKSIDRRPNAIQTLLAGVLACSPAPTLPPHVVRYLAKTFNVWHTGLELLQETLENPREEDSVREMTLDALAETYSELSEDDLLYGLWRRRASYNETNAAISWEQIGQWGQAQVLYESAQITARSGVQPFTESEMALWEDHWIVTAQKLQQWDVLMDLAKNEGNKELLLECSWRLTDWNVERDFIEQTLSSMSPITTPRRRVFEAYLALLRAYPKDVNNDGSAKKAFAKLCDEGIQLSLRKWYYLPEAVSQAHVPLLTIFQQFVELQEANAIFASLHATDAANLDQRSNELKTILGTWRDRLPNLWDDINVWSDLVAWRQHVFQAINATYLPLVPQAAPGQPQNASSFAYRGFHETAWIINRFAHVARKHHLNEVCVTSLTKIYTLPNIEIQEAFLKLREQAKCHYASVSELASGLEVINNTNLMYFNASQKAEFFTLKGMFLAKLHLHEEANQTFNLAVSMEMAFPKAWAEWGEYHDRMFKENPTDLGIASNAVSCYLQAAGLYKSAKVRKLLVRILWLLSLDDAQGTISKAFDSYKGEVPTWYWITFIPQLLLSLSQREARYSRVILLKIAKVFPQSLFFQLRTVREDLSMPKRQHMAAHIQAVQAQRMNEARAAGLDAEATAVLRNEPIPAPTPLPNGPRHPWEYVDEIMSILKTAFPLLALSMEMIVDQISTRFKPTPDEDIFRLISALLADGLQQFLARAGMPNDDGKLAAPTISNVTRFAENLHPPTIKESFVQDFLTSEPTLAQYVQRLQRWRDRYEGMLDKKAKKANLEAVSHWLVEFQYQKFDEIEVPGQYLMHEDNNGNFVRISHFANKFDVTRSHGIYFRRLTILGHDGSTHRFAIQVPSARTSRREERIMQLFRMLNCPLATRKESRKRNLAFNIPIVVPLAPNVRLVENDASITSLQDIFEQHCDLAGIKKEDPILAHTERVRALHHHDPPLSRTELWNARQEIAEEIALKMVPDDILKKYMIRSMASSSELWHIRREMTLQMAAFIFMTYVMSMGVRLPSRVHISRSSGKLLTSDMLPSIIPTKPEFFNNEAVPFRFTPNFQRFITPIGTEGLLTSSMMAIARCLTESEVSQEFDFEHRLSIFVREEILVWAQMAKSDPRGQLRELVLRNVDVVVQRAKVMSCKMEREKVRLCSVSPPSASVPVNQSILELLLSATSVQNLSKMEPTFAPWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LUR0</accession>
    <name>A0A2X0LUR0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C017g08350 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C017g08350</name>
        <name evidence="1" type="ORF">BQ5605_C017G08350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY19852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LUR0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY19852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="129" mass="14758" checksum="37DD98EC8F6A623A" modified="2018-09-12" version="1">MSTHPSAMSISPSSRVLVVPPDAESLRLIGQHLGAWLDKRRSLLPTWRMMIRCSLRQLVLSNVKLRLEQLQIVCQTHNLQGYSLRRSRARELFLRIMLSSCTESCPAYGIAYPATRSTGTKHWIRVKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LVD1</accession>
    <name>A0A2X0LVD1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C016g08058 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C016g08058</name>
        <name evidence="2" type="ORF">BQ5605_C016G08058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY20457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LVD1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY20457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="84" mass="8705" checksum="11E171BF95ECEE1A" modified="2018-09-12" version="1">MSDDGDDDTCADSGEGRCTVEDEEATAWCEDDSICVGFAMITISSWMVGAVTGTVQAQGAFLELDLGGTIVGPLRSAETGLSEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LVM3</accession>
    <name>A0A2X0LVM3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">DNA topoisomerase 2</fullName>
            <ecNumber evidence="5 16">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">BQ5605_C013g07129</name>
        <name evidence="20" type="ORF">BQ5605_C013G07129</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14 16">Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15 16">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="16">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the type II topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="5 16"/>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY14848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0LVM3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16930">
        <property type="entry name" value="HATPase_TopII-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03481">
        <property type="entry name" value="TopoIIA_Trans_ScTopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03365">
        <property type="entry name" value="TOPRIM_TopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.40:FF:000003">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.30:FF:000001">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000008">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000004">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.670:FF:000001">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.199.10:FF:000002">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="entry name" value="Topoisomerase II, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="entry name" value="Topoisomerase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050634">
        <property type="entry name" value="DNA_Topoisomerase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001154">
        <property type="entry name" value="TopoII_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031660">
        <property type="entry name" value="TOPRIM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034157">
        <property type="entry name" value="TOPRIM_TopoII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169:SF38">
        <property type="entry name" value="DNA TOPOISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169">
        <property type="entry name" value="DNA TOPOISOMERASE/GYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16898">
        <property type="entry name" value="TOPRIM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01158">
        <property type="entry name" value="TOPISMRASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00418">
        <property type="entry name" value="TPI2FAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="Type II DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52040">
        <property type="entry name" value="TOPO_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 15 16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13 15 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15 16" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="18">
        <location>
            <begin position="656"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IIA-type catalytic" evidence="19">
        <location>
            <begin position="902"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="118"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1506"/>
            <end position="1562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1567"/>
            <end position="1586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1592"/>
            <end position="1683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1506"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="1535"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="1592"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1638"/>
            <end position="1660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="1664"/>
            <end position="1677"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="15">
        <location>
            <position position="992"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00053943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS52040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="SGY14848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1683" mass="185735" checksum="03E2401115554F4D" modified="2018-09-12" version="1">MKMVDDGSDFSDAYVAGGASKTKKVGSLGLESGGGWRDERVSLNPSQRPAAPMDSVFCSVSLDSLDDLNITPPDWTGAYHGSIMSFRLIPPLPFLLRTCLIPQHPTRRLPLHSPFHQTAAPKAAPKPKAAAKPKTATAAAAAAGKKKKVLQEHDTNGASSADEAYGMEDDDHVPEMRIPSATKKTKAKSASETYVKLSQLEHVLKRPDTYIGSIEAVTQQMWVFDPDTTGGTGGTLVNRQTTFVPGLYKIFDEILVNAADNKAKNAEMSYIKVTINREDKKIVVENDGPGIPIEEHKTEKVWIPEMIFGTLLTSSNYDDEEEKVTGGRNGYGAKLANIYSTEFVVETATSNDMKTYKQTFKNNMGTKGKPIVKDITKAQDYTRVSMIGFRVITFYPDLARFGMTEFDDDTVALLTKRVYDMAGIIKGVNVYLNGKKLSLKNFKQYVEMYTAAIEAASKPSTKKSGENEDMVESLDLVGVDPLAAGKKNSVIYGQFGQWEVAFALSDGQFTQVSYCNSIATTKGGTHVNYIADQIVSGLVDLIKKKNKAAPVKAFQIKNHLSVFINCKIPNPSFDSQTKENMTLSVSKFGAKFKCVLDDDFLKKVARSGVIDNVLNWAKFKQDQMLKKTDGHKRSRITGLVKLEDANNAGTRNGSKCTLILTEGDSAKALAVSGLAVVGRDNYGVFPLRGKLLNVREAAGKALLDNAEIQAIKQILGLQQGKVYTDVDSLRYGKLMIMADQDHDGSHIKGLIINFLDYWFPSLLKLKGFLLEFITPIVKATKGNKELSFFTIPQYEHWKEETDDGRGWRIKYFKGLGTSDARDAVKYFGNMDKHRLPFRPSTQEERELIDMAFNKKKADNRKEWLRGFVPGTYLDHSIAEVPIEDFINKELILFSMADNVRSIPSVIDGFKPGQRKVLFGCFKRKLTQEIKVGQLGGYVAEHSAYHHGEMSLQGTIIGLAQQFVGSNNLNILDPNGQFGTRLQGGKDAASARYIFTNVSSITRSVFHPADDSVLEYLNDDGQSIEPSWYIPIIPMALVNGSEGIGTGWSSSVPNYNPTDIVANLRRKMRGEEMEPMHPWYRGFKVSNANRLCKSSSNIDLNINDWRPQGTIEKTEKDGYVSTGHIERLDDATVEITELPIRTWTQTYKEMLESWVVGTEKSPALIKDYKEYHTDTTVHFIITLTEKGKDAISKEGLEKCFKMQNKISISNMVMFDSQGKIKKYATPEEVLDDFYDVRLEYYHKRKAFLVDELTNIHDKLSNQARFISMMISKPKQLTLDNRSTADIVQELRAKGFRPFPKVQKAAVAGVQADAEEDADADAGMDSDYDYLLSMALRSLTKEKIQRLEAECKTKHDDLNTLLALSPKDLWSNDLETFAAQWEQLLEHDSVAHEKASRAAKAKGKGTKKGKKAAAYSEDEEDVYGDEEDFVYKPKPTKRAPVVKKLKTLPSDDGKDDFGVEAKELVVKKVSEESRSFLLHKRMLTHSASGAQSATPAPVAMDVDDLAAKPKPAAAVSKAGAKKRVVDASSEADDTPKKKAKPAPKPKKQVALSDDDDDIDASFAKPVKAPIAKKAAARLDDSDDDDDTPIIKKKVVVAKMKPKASPKAAAKSKPKAAVKSKQLTLSDDDSDAGSSIHIESAAKVAPKARAARAASTKAKAKAAYMELSDEDDGGDGDDASDFNGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LVV1</accession>
    <name>A0A2X0LVV1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C019g08857 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C019g08857</name>
        <name evidence="3" type="ORF">BQ5605_C019G08857</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY22790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LVV1"/>
    <dbReference type="STRING" id="796604.A0A2X0LVV1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025239">
        <property type="entry name" value="DUF4187"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039249">
        <property type="entry name" value="GPATCH11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032:SF0">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13821">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01173">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="82"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY22790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="390" mass="43697" checksum="F1D1B7D97FCCCB1B" modified="2018-09-12" version="1">MTPSLEDEEDIDFDDPRFLIDPAPSSSSSFELTYADRRRKMIGRGREKARASSFEQSKVGRAEREREVREEGLRRDLIREEVGNVGLRMMKNMGFEPGQALGKKRTVAQAELETDASRASSGSRSGLGEDDRPKGLGFRNEAGTANTGTGETTGLGQKGGHQPRLEPIAFEIRQKRTGLGIPQPSTRPNFSFLNLKNGSSTIDPRPLENVDSYLANVKATLDSRKAFGYLRSLRRTLETLDRGAGVEDSVMWKDPDEGEWDVDEGSALAKKRILGREKVWALGDWEEEEERGEVGRTKDGGSLGYARGLNNVVVELEEDEEAGQGEKPDPAAVEEARERAEWMALDTRTRLAYTLSYLRREYQYCFWCGCRYEGKEDLEANCPGENEEDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LWL5</accession>
    <name>A0A2X0LWL5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C018g08623 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C018g08623</name>
        <name evidence="10" type="ORF">BQ5605_C018G08623</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY25478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LWL5"/>
    <dbReference type="STRING" id="796604.A0A2X0LWL5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000120">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF176">
        <property type="entry name" value="HEAT SHOCK PROTEIN 78, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="142"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="536"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="9">
        <location>
            <begin position="707"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="354"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY25478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="828" mass="91229" checksum="50A692436C53946D" modified="2018-09-12" version="1">MLQRSSLRSLTSASTAPRLLRPAHRHGQLLWRPTIQVTTTQPTLRRSSLQARSFSHSSPPRAPAQHPPPPGGNNNNHNNAGGGGGGFPIGNIFNSQPKREPGAALKEHGVDLTELARQGKLDPVIARDDEVRRTIQILSRRTKNNPVLVGAAGVGKTAIIESLAQRLVAGEVPESLKGKKLISIDLASIMSGTAVRGSFEGKLKDLIADIEDAKGQIIVFIDEIHQLLGLGKAEGSLTGSNMLKPALARGLQLAGATTWNEFRELEKDAALLRRFQKVTIEEPSAEQAITMLRGGKSRMEVHHGVIVSDAAIIAAVTYSQRYITDRQLPDKAIDLIDEAAAALRLARESKPEQLEALEQHLTTLQIELSSLGKDQDEASRSRREVLVDEIARLKNKASKMEKEWRDERERGEKIRQAKEELERKRFELEEAVRTGQFDKASELRYSTIPKLEAQVPKDGQEAAQAGQARVTASDVARVVAKATGIPVSALMRGDRARLVDLESILRQRVVGQEPALHAVAEAVRLSRAGLHNPNRPVASFLFLGPTGVGKTELSKALAAELTGTDRLVTLNMSEYHDKHTAARLIGAPPGFVGYEDGGELSVVRRHPHSVILFDEFEKAHPSVANILLQILDEGALTDSHGRKLDFKNTTIILTSNIGSDILMRPESISPNGEVTPVARDLVLERVRSLYPPELLNRLDEQIVFNSLSPTHVASIIDMRLSEIQQMLNTSERKIHLSIDPEARDWLAKEAYQPRWGAREVNRLLNKVVRQQLASGILKGTIRDGDTARFRLKEEGGKKSVELVPVHEEEVFGDSKREDEELMRADELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LWT5</accession>
    <name>A0A2X0LWT5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C018g08720 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C018g08720</name>
        <name evidence="1" type="ORF">BQ5605_C018G08720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY26318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LWT5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY26318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="133" mass="14628" checksum="E858747C0D7F4F16" modified="2018-09-12" version="1">MLGNCNDPSLAYYYLPNIDSPAPTSNDSDGGASSRIASYVPIHIPPEDRSTQALIRVVREPLFLECNLVSLKLLYSLLSPYLPEVMAPNPETLATGSTSLNGNGQDASWIRQLSLEYSIDLQKTLDEEKEPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LWX8</accession>
    <name>A0A2X0LWX8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C015g07739 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C015g07739</name>
        <name evidence="1" type="ORF">BQ5605_C015G07739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LWX8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY17302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="201" mass="23164" checksum="1FCE6E07F7F95671" modified="2018-09-12" version="1">MVKLLMSTERINPFHLVQTGPNQHRRPWIWIWWAYFCHPPPTWDHAVRKTTKLLPARWVRYPEAWASVTTLNPPELSKSENLEQWATHVLYFPAGHGIQLSVNPTLFRGPDGEVMTPSSFVNASKRHQVFIFPPIFPKGHQKVFDLPEQRWNAWWKALRKVRRVHSGAEDTGHLLSLGSLYPGSQIASPTSPHPDNHLPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LX03</accession>
    <name>A0A2X0LX03_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C015g07858 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C015g07858</name>
        <name evidence="1" type="ORF">BQ5605_C015G07858</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LX03"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY17691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="318" mass="36650" checksum="1D6041B5DE301FF7" modified="2018-09-12" version="1">MLQSRTEVKRNGTCALSISNRPNPLQPLNSSEYGRWRVLSDLFKRWIWWAYFCHPPPQWERAVRKTKVLLPPRWIRYFEAWDLVTTLNPPELSKSPNLERWATHVLYFPAGHGIQLSVNPTLFRGPDGEVMTPSSFVNASKRHQAFLYPPILPVGHQRVFCLPEQRWNAWWKALRKVRRVHSDAEDTAHLLSLGSLHPGSQLASPNSPFLHNRSTACVMCLSEAPETLAHLAVGCPFARRLWSALTPFPHPDFVQFVCPVVSRSERRLVELCLLFFHAIWKLSRHRRFSSDPLEPIAETAFEELRASIQKSKGRLVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LY34</accession>
    <name>A0A2X0LY34_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgi apparatus membrane protein TVP38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Golgi apparatus membrane protein tvp38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C015g08027</name>
        <name evidence="13" type="ORF">BQ5605_C015G08027</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking and spindle migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY18278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LY34"/>
    <dbReference type="STRING" id="796604.A0A2X0LY34"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000022">
        <property type="term" value="P:mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051076">
        <property type="entry name" value="Golgi_membrane_TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549:SF1">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="76"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="12">
        <location>
            <begin position="95"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="273"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="319"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="278"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGY18278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="378" mass="42620" checksum="F5C099E138888A6F" modified="2018-09-12" version="1">MVPLFRNVQHRARETFDRARDYYDSLSSTSKLIFWTWVGLHVFTIALVIYLTPVQLFAWMADWAATLSDMGPSGRLVLLSLIILTSFPPLFGYGTTITLCGFAFGTFQGWIIAALGCVIGGCLSFVVTRKMIGSFAPMLAREPTFVALGRAVRVKGLGLCILIRLCPFPFPYSNAFFASIETVTLFQFFLSTLCITPKLLLHVWIGSRMFLFADPDSRNRMDPRAKFVNLVFVVMGSVMGMLTSWYLYRLTMTYVQIGAGRGVELEDEEAILGRGEHDEDDPDDDQDQDEEEQDRFPVSGGGLLHDVDQLLADQDFDHDSMPLKERSTNQFNHQRSSFDGHVYRQKGSIKLGSRGQNGWEEAMADFGEEHEGEEEHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LY43</accession>
    <name>A0A2X0LY43_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">BQ5605_C014g07412 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">BQ5605_C014g07412</name>
        <name evidence="17" type="ORF">BQ5605_C014G07412</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY18610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LY43"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015882126" evidence="15">
        <location>
            <begin position="23"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="16">
        <location>
            <begin position="192"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="SGY18610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="410" mass="45287" checksum="35B82B7C755630AD" modified="2018-09-12" version="1">MAPLWFLSCSSNFLVWSPLVLRSETYHCLSSDSIDITKDGQAIAHGTRVNDGLYLLDADHTKCQRLAFLSRSESTVPLLTLHRCLGHLAPSSIQKMIAAGLLDGFGAGYSDKDVEEFVCNACLGSKGHCLPFPDSESHSPERLGLVHSNVLSFPTPSLTGKRYLVTFLDDHSRKLLGIRNRSQKRQTDARLRILRTDNGGEYQSNAFTEFCQSRGIRRQYSIPYTPQQNGRAERVNLSIVEGVLALLADSHLPATFWDEAAAYFVYCKNRCSHSALAKQTPQFVWNGQRTTTTVLHPFGCAAWLTVAPDLRSKLDPKATRVSFTGYDLASKAFRFFDHSTNKVVLGQNATFLDDDFPGLPVNMPVNADDTERQFVIPADAPAPDPANTHAPAVKTRTPLVSDVVLAKSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M015</accession>
    <name>A0A2X0M015_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">triacylglycerol lipase</fullName>
            <ecNumber evidence="2">3.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C019g08905</name>
        <name evidence="7" type="synonym">BQ5605_C019g08899</name>
        <name evidence="7" type="ORF">BQ5605_C019G08899</name>
        <name evidence="8" type="ORF">BQ5605_C019G08905</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="2"/>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY23110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY23144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M015"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF1">
        <property type="entry name" value="LIPASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036522048" description="triacylglycerol lipase" evidence="6">
        <location>
            <begin position="26"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR029171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY23110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY23144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="426" mass="45334" checksum="E083562268EF4B24" modified="2018-09-12" version="1">MLSPRSSWFARVTSSILALTVLVSAAPILDLTSPATFLIPTPDVDPFYRPPSTFAKDAPGTVYRSRAALNPGFGRKGTQILFRTSDAFGKPTTSVTTILQTLNSSKNYLVAYNMYEDASAPQCAPSYCFNTIPQKSFCPDGDGQLVYFMTKGWIVIVTDFGGKTSSFSVGHQSGYQILDGYRAAIKFLKLSENVVLGGYGYSGGAIGTGWSAALQNNYAPELNIKALAFGGTPSNMTSTFYQLNAGAFAGFAVGGLAGQVASYPELNARFSQIATAKGKAAIITGHSQCGAADIVEFAYTDFLSTDFQSLGSQLLFDPIVSEYLTMSTMGSVASETPTKPSILMFHSTMDEVIPYTSALKTAQTWCSDGAKITFITELGGGGHLGTQISYGNMTIDWLDNSLRGTSAAISSCSFETQSTKALPVRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M071</accession>
    <name>A0A2X0M071_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C003g01895 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C003g01895</name>
        <name evidence="3" type="ORF">BQ5605_C003G01895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY37821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M071"/>
    <dbReference type="STRING" id="796604.A0A2X0M071"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050278">
        <property type="term" value="F:sedoheptulose-bisphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046390">
        <property type="term" value="P:ribose phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF15">
        <property type="entry name" value="SEDOHEPTULOSE 1,7-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="29"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="102"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY37821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="230" mass="26112" checksum="D8B6EE044FB9FD97" modified="2018-09-12" version="1">MGKHGHPTMPRLILIRHGETEWSLNGRHTGKTDIPLTSNGEELVRSLGQRIVGKGKMLDPDHIQGVLVSPRQRAQTTFNLLFRENLDEADVPKSETEQDVQEWDYGKYEGLVSKEIRERYKEDWDIWVDGCEGGESAEEMTARCDRVIAKIVNMTRDHHESNEEHRSGKGDVVVVSHGHFTRCLLTRWCELPLTDGRRFGADTGAITICGYQHGSFKERSLLGMNLFGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M0V6</accession>
    <name>A0A2X0M0V6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g02115 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g02115</name>
        <name evidence="2" type="ORF">BQ5605_C003G02115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY38976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M0V6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY38976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="300" mass="32086" checksum="C0BC9E481E791695" modified="2018-09-12" version="1">MRLLISDVEYKLTLVPKGHPDWQRATAPTLETRIPFVDETGAALDPGRLRHHTNDGIRPTSSMGIPSASSLAPPTPALNTRLVQPDEGSVHAMTTLVYRKTLDPVAVYYKIGKKTCVFLPVILRAQTQLVIGGAEEYPRWLQLGDLQPGAPLEQAVAALGKAQGEGRARRSLRSGNSAQNVDVEMAHTSDLGPSHTLDPRALPFLAPSHSSTSIDPGPSQPLLQHAQPTPSRSSAADDHRVRRPIDNDSDAIELASDDDAMGGNGNGKPKGKGKENERMDAEGKGKAKAAPPPTKRQRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M103</accession>
    <name>A0A2X0M103_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C008g05237 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">BQ5605_C129g13356 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C129g13356</name>
        <name evidence="5" type="synonym">BQ5605_C008g05237</name>
        <name evidence="5" type="ORF">BQ5605_C008G05237</name>
        <name evidence="4" type="ORF">BQ5605_C129G13356</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit p55 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000021">
        <property type="protein sequence ID" value="SGY27386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M103"/>
    <dbReference type="STRING" id="796604.A0A2X0M103"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000070">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040896">
        <property type="entry name" value="RPN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18098">
        <property type="entry name" value="RPN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="254"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY27386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY79857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="539" mass="61358" checksum="8434BFB6D9305E2C" modified="2018-09-12" version="1">MSQAPRKQEADHTKDCDETIPVAESLASSGQVQEALDKLLTLEKLTRNSADLASTTRVLIAIISILHQHKQYDLLNTHITLLSKKHGQLRQATQKMVDEAMTYLDNLDGKPKLDLIETLRDVTEGKVSLVRVFRTCMHQSNTVNSTQIYLEVPRARVTRMLATIREKEGDVAKANELMQDLQVETFGSMERREKVDFILEQMRLLKALEDWDKLGIVAKRINVKWLTEKEHEDLKLRYYSLMILWGLNAGKYLDVCKFYRQVYETPSIQDDEAKWSAVLRNIVYFVILAPYDNEQSDLLARVFKDEKLVKVTESYDLMKCFTAPELMRWPGIEGLYGASLRQTKVFGSTGVAGVAGDIEEDSKHSQGDKRYEVLHDRIIEHVRSLDSIEAQHSTAQHSTAQHSTARLTDLKTHGWRCTKQNIRTLSKYYTRMTITRLSQLLDLTPAKTEAFLSSLVSSKTVYAKIDRPAGIVSFQAPKSGDEVLNEWSSDVGKLMGLIEKSTHLIQKVSWKHLGSDGLEKPGTDRPSGFAPRNMRCMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M1F5</accession>
    <name>A0A2X0M1F5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C003g02355 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C003g02355</name>
        <name evidence="9" type="ORF">BQ5605_C003G02355</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY40331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M1F5"/>
    <dbReference type="STRING" id="796604.A0A2X0M1F5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF191">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="548"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="72"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY40331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="587" mass="63467" checksum="53D62FDBFD389C21" modified="2018-09-12" version="1">MPETSERTPLLQRGLPTARHGWESSPKPVRAFRTIRPLHPSGLSSSNNYDHPPIPDIVRLGIDLSRWHKLAILTGTFVAVFLSSVDTTITTALIQPIAIDLRDGPHHRAGWLGPSYLLSSLIVTPFYGRLCDIVGRRKAACSAVLLFLLGTLGCSMAPSMPHMLGARILAGCGYGGMMTTSAFLTADLFVLKERLLYGGISGVFWTLWSLSTYLDFSSPAVPVLVAVLVGSLCLIRYTSDVPPAHSSWSMLTRIDFGGCATQLLAFGTFLVSLGLRNNDLLPWSDSKVIFTSALVPVFLAAFFYIESNIAREPILPLDLLKPRTPFFALGVTFLVAITNSALLHHLPIYFMTVESRSEVNAAAHLLPVSISAAIGGLTSGIWMFRTGRYWGAGLTVSIVGEQRTKYDTSRVSYFAVIRSALATYSTLLLQPSQPELLKWILVIPLGIAPSVAKATSYAAMMAYIPPSQIPIISGALWAFRSAGQIIGLGISTTVFQSLLVSTLREDLPRTIADETIHRLREDYMFLNTLDPELKAIAKKAFANATKGAFGVAVAGVTLTVISFALIPVHSLTLEQEDVPPAAVAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M1K0</accession>
    <name>A0A2X0M1K0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C003g02438 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C003g02438</name>
        <name evidence="8" type="ORF">BQ5605_C003G02438</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY40896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M1K0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY40896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="372" mass="39860" checksum="C7222CD4EAC4F258" modified="2018-09-12" version="1">MPHEGDERLFESVDKSDGRNVEREQVDDPRSDIRVGVHRASPWGNTSIRRCLQSSLCSVECRAPEEREIAVDGNRIASPSHALTSAHSRDPAGPLVLSPAQAERESSGLGRVRASVCSQAPIDGEASREIECCRPRKRSGLTPLQATCPGVRSQMIVAVLASRIESESQTRPSCLYRAFQFPAMILGVLGADFIFACSIFYVSKVAGPGQQSLATGLFNLSTQLGTAIGLAIATIVQTKVVDKKVANVIVSTSSSAPPFCCGGGAEGGILDVCGFFVRGFGGRGTVLEGYWEGRDEDEEGYGGGGIGTECVHNHHGIVLLGHAFWPRGQGIWTSIGADDTELSYVSGRNGLEHQLFLGELHKLFDHQRQALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M1P0</accession>
    <name>A0A2X0M1P0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">BQ5605_C127g13345 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C127g13345</name>
        <name evidence="14" type="ORF">BQ5605_C127G13345</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000025">
        <property type="protein sequence ID" value="SGY27583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M1P0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="7" id="KW-0229">DNA integration</keyword>
    <keyword evidence="11" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="13">
        <location>
            <begin position="108"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="12">
        <location>
            <begin position="423"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGY27583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="486" mass="54566" checksum="15F5DB910D99D349" modified="2018-09-12" version="1">MADVSGDEEGRILRVHPDESLSLFVPRGLATGVVDSDKVPSLRELVLAEIHRSVGHAGHRITLAAIRPLYWWSSMSADCAKFCHSCEDCARGKASTQVPYGRLHPMPIPSGPWEQVAIDFMTGLPPVEFEGMMVAQIMVVTDTWGKMVRLIPLPADADSELVADRYYATIFRLHGTPSAIVSDRDPKFTSQFWRALQAKVGTVLRMSTAAHPETDGSSENRIKMVTQTLRIMVSSNHEAWASRLVEAEFALNSSVAVSTSLSAFEATYGYLPRRWPTDSWSVSDVPRAEAFARIRQLRNLDVTDAIIGARLDQTHQANKHRRPDDPAFRTGSYVYLSTKNLAVPEGMKSKLLPRYIGPFRIRAAIPATSSYDLELPPAMSRVHSRFHARLLRPYVENDAERFPGRDPAVLFVEDVADAADNSAIPEQIVRDRRNARGNRSFLVRWIGRKDIDDTWMSEQSLRFDHPSLLDTYLAQLDRSNRRLSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M1P1</accession>
    <name>A0A2X0M1P1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g02488 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g02488</name>
        <name evidence="2" type="ORF">BQ5605_C003G02488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY41253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M1P1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY41253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="62" mass="6820" checksum="92E86AE3E8AEA4BF" modified="2018-09-12" version="1">MALDANKPITPSTPQQRDNSSCGPAIINIVEKELLGTAAFDPGCPKMSRVRQFQRLLFDFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M1Q0</accession>
    <name>A0A2X0M1Q0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g02465 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g02465</name>
        <name evidence="2" type="ORF">BQ5605_C003G02465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY41063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M1Q0"/>
    <dbReference type="STRING" id="796604.A0A2X0M1Q0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY41063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1181" mass="132766" checksum="AB391A10C64658D8" modified="2018-09-12" version="1">MAGNTTSRPCPCSWCKGASVSKATFYRHHARQPNEPRATEKAAILEVPRQPSMLLAPPGPQSQLFQPPRPTPSWFATRSPQKYTQSAERIVSRKAFVGSSMGAQLNDSALSNDTQAYGSVSSNISHTDAPNSPSLPYESEEFSMNISPELPQIPEGDYDFERASWTGGSMDSFEGHALESDQDVLRQTQLFEMTSALETTCPALQPLDNYSSSSLPFDDDDPLVVEELWGADQRLDANGVYNTPTTSRLSSSQERAVAEEEVRQEIELAKALPYYDVDTLYDFSFRHMYNMTRQASKIWEVLGSRPSLQKFVDLGLKPVRIPCCVKTCVAFTGPREALTRCPVCSSPKLDQNGHPQNTFLYLSPDVYLNIYLRDRVYASLMRYRSDFERNRDPQEVVDLFDGDRYREKLDQNISWTNPPIAGASQPTVSTINVKYYENDVDVAFELFTDGIQLFNKTQSECWPIMMINYNLPPEIRYKKKHLMTVGIIPGPKGPKDIDSFLHPLYEDARASARNGHMVFDGVTETMVRQRWFIHVIGGDGPALSKMLGFKGPTAKWPCRVCLIQGVPCAAAHNHNYYPLKMPLDSSHANRSDLTALDLPMRSEATIREAASEKNPTFGLSKLSSAAHLPGFSLHQDGPSDFMHAVFENVARKLFNMWHGDLVAQKSKGYKTQAPQAQRGRSAQGKVTSAASAEATTSAAAVDEALGNDLPDWVIPNKIWEVIGQEITNGAKTIPSLFARKMPNIHLQTGAIAEDWSNWILYVGPCVLHDRLPAKYFAHFLALRRWVKDCMAMTINKEDVAKNGALRRDIASWCTEFESLYYSGKSAHLINLPHSVHAVLHIADFIEWHGPPAMTWCFAMERLNQTVKRVASKAHRLPYEAVNRYVCADAALQMACSRFPRFSYPITVPALMKHQQDKQMELEQMQQSRGLFMNATGDQMRALGLYGRRSDKLKQGPGINDVMRVAQFIARELFGQLAPVVFKRKVDAIRTSILSLSINSFEGYRMDSGRDRIAAAKRLSKHARVSADTRDASWISYDLLIDSSRRRARDNSQAFPREGEGADRVKHFGQLLAIYEFRYGEQVRSLGLSHLQPVDTVERAPIAKPTPKRQKRKALSVVGGHKHQNLFFTQGKRASGAVEIVDLRCILGSAGRIHRRVGREESREYIFDRMDDEARPNFLNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M392</accession>
    <name>A0A2X0M392_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01732 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01732</name>
        <name evidence="2" type="ORF">BQ5605_C002G01732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY35153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M392"/>
    <dbReference type="STRING" id="796604.A0A2X0M392"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050754">
        <property type="entry name" value="FKBP4/5/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512:SF9">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY35153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="187" mass="21008" checksum="A59F4EA58A819943" modified="2018-09-12" version="1">MADVERQRQLRETVSKAIQVRLQGNEKFKAGDLQGALQDYHTVLFSLRGLDGSIQEAMGATPKMHRPSQSGAEASLDDEAKAQRELTDKVKQAIVSTHINMAMIHFKKAKWQRSLDCALGARKIEADNPKARFREAQARIKLGLVTTGKKMIEDLQKANPDPAFVKALNDLQLEEKARAEKNNQQFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M3D8</accession>
    <name>A0A2X0M3D8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C002g01510 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C002g01510</name>
        <name evidence="5" type="ORF">BQ5605_C002G01510</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY33556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0M3D8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052007">
        <property type="entry name" value="Bud4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36100">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36100:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="1276"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="154"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="296"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="422"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="529"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="904"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1126"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="360"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="533"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="551"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="581"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1126"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1147"/>
            <end position="1160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY33556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1412" mass="150102" checksum="CD818CA8B6D8811F" modified="2018-09-12" version="1">MAAMTMMTASSSPMRTPGLYSSPASPSTLRSPQAPRPASSSTALPLGTSSSANANSTSWSCPDRRQPVSIVAGADGGAEAIAVRRRGSNSFRIMSTGSLVSNSPFAKRLGQVTSSPKLNDITPPTMSPTSTLGSRIPTTTITKYGGLSVGLGALNGSRRKVSGENEENRNVSAEYANLDEHEGKVIFDGTGEGLPRSRSASPTVPFRPIRSVNPSHSTALAGSTTTGSSNAAFKPSRPAFTSTNGSHHAKSASVGSGPVSNSLFLNRAKDNEISPPLQQAPYEIAPLSHESAPFSFHTTSSSFSQPRVAPIVPRPMSSTGTPISPFSLGHRPGQASLNGGERRFGGAAEPPPNTPPRARSATSANNGSPAPASAMSPHRRGAHSSTESETESTASRVIRRQPSAKTVTWAATEEVLEFEVDDRRASGVSYASSTSDDARYYGREQDDSTEVEEGNSSMGFEEGGSVEVHDYNSSEDEDDDGESAVSTVDELIDNIDQFMVEERGYNEFYSPSQITSDFDARPMAEALQVAAPSSTFSSSTTTTTSSGISTGEEEGEDASNYSNDDDAEGDVTQETIAAHGDSAPDASANASSSSSPWSLERPLPNFPSSDRDFLDSVLMMDSPKQSKVSISTFELPDIPGISPLMDFGDDGSAGSVVTLDMDPAVTTTITRASMSALPQASHPFSSSAYPVRSVAQSAPAQLSPAQPVRQELIGDSPILSAFNRTSAPVQPLQASPQLSRKGSVHSDAASSLSYYGSISSGSNGPIFMGRGRLDEKLSAHQAMLEALSPSSTSTGRFPDTNNSVPSIKARDFALDDDRSQTREIQAKAAIKPSSATLSTGMMPTIHGSSVVQGLNIGVGSLLTPQLAHAMSSPLDRLQKGVERAEGGSVWKTGDSLLLGVAEVPKEAEESEDEEDLKTSMKNSGGRPTRRRSLSTGDAKVSETTSSTDDTPKKLELRFERRLAGVPEVEAFGMSTQCSLDDIFNSRHHSYRVREHKVVINATDSNRLTAVNKAGDLAASPAVRRKRPSNMHEINRSLSTVSVTSTASRRSKAFRGQLFVHIREVQIDGVPMPRERTNVIFSLDNGKQRVEAGRRVLEPHIAVRKEFELICSPDLVFSIDLSVGPPPPSPVPVPQVRRTPPPPPSPTKTPGSRLRALLSSPKKKAASNAKAAAATSALPPPVAVAPDPFYSFVAPDGKLASATVRFVDEALRCRHKRARITIPFSKNPALPSNRRVSGSVTIDLFYLPSISGINKAALPKSMDESIEGMRLAETSIGVTHEGVLTQMGGDCSVWRRRNMKLRANRLVPYSEVTKMSHVEIDLSVVASIEDLNATVASGGKSAANFDADDVVSTMDNSFRLVFKDDTSIDFYADTAESKKRWMKEISQAISVTGNEPVPQWALLAKRQAAKKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M648</accession>
    <name>A0A2X0M648_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine-threonine kinase receptor-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C003g02492</name>
        <name evidence="9" type="ORF">BQ5605_C003G02492</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY41286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M648"/>
    <dbReference type="STRING" id="796604.A0A2X0M648"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF13">
        <property type="entry name" value="SERINE-THREONINE KINASE RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="94"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="135"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="200"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="337"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="23"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="25"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY41286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="384" mass="41006" checksum="0686FC1B716384F5" modified="2018-09-12" version="1">MSIPVRSTPLVCSGHTRPIPSLHFSCPSGSGSGSSSSSISNSSAPTPSSSEGPTSSTSTSTSTSDPSYLLISSCKDGKPQLRNWLGDWVGTFVEGGHKGAVWSSRLSQDGERAVTGSGDFTAKLWDTTTGSCLSTFNHNHIVRSVDINASSTSLLTGGAENKLRLWDLTRSSISSSEATEDLISPTQEGACVEFKDTGSDTAHEGTIKTVMFDDEARQVVVSMGEDQKVKWWDIRTLSCIHTLSLPNPITSLSHATPLGPLSPSPQLALTTTQALHLYSLSDPLVHSEPLTTHSLSYTPSTASVHPSPSKPLFVTGSTTDNWVHVHDLSTGEEKELGKGHHGPVHGVSFSPDGEMYASAGEDGTIRLWQTEPKDWGLWRYNDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-05-29" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M7H1</accession>
    <name>A0A2X0M7H1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C007g04580 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C007g04580</name>
        <name evidence="1" type="ORF">BQ5605_C007G04580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY61634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M7H1"/>
    <dbReference type="STRING" id="796604.A0A2X0M7H1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004113">
        <property type="term" value="F:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009187">
        <property type="term" value="P:cyclic nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012386">
        <property type="entry name" value="Cyclic-nucl_3Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28141">
        <property type="entry name" value="2',3'-CYCLIC-NUCLEOTIDE 3'-PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28141:SF1">
        <property type="entry name" value="2',3'-CYCLIC-NUCLEOTIDE 3'-PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07823">
        <property type="entry name" value="CPDase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY61634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="211" mass="23294" checksum="45162469FD3C3750" modified="2018-09-12" version="1">MAPSPLTGTFSGIALWLSPPWASSQNDYLSSLINSLSSSLNTPPFDPHITLLSGLPTSTPLELIISSLARSIKASDLKKCKVEFKGIGTHHRYFQYLFAIVNKGNEGLLRLRTIVQEGLEKDGLLHDDPQTGKKVERVEQYFPHASLVYGTDIEGERSVKEVMERMRKEGHAFEDGVSVGSAQGFQVEEVLVVVCEGKPEEWKVLGRVALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M7I7</accession>
    <name>A0A2X0M7I7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C007g04600 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C007g04600</name>
        <name evidence="5" type="ORF">BQ5605_C007G04600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY61778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M7I7"/>
    <dbReference type="STRING" id="796604.A0A2X0M7I7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049945">
        <property type="entry name" value="AAA_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF26">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="180"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="432"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="566"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="643"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="643"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY61778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="718" mass="77695" checksum="8DAAE564B5BDB3E7" modified="2018-09-12" version="1">MPSIIGTPTRSPNKRRRTKSKEEEHSSVEESPSAQEVCMMLLGTPRRTRTSPSQLVTPMKATAKRRSHSPVLKENVPVHSDSTESHSDQDELIFTPSKEIVKPEDTLPTPHSTPTKDRVTARPIKDIYTHALQLLSPSGSALPTILGRDSQRATLVTFLARRFPQVYRDHPTSASDNAIPPASLYVSGPPGIGKTALLSAVVNEFSALVEQQDLEDEIKVHMQTCQTSGATQSSIWDRLGRGLGLDMSLGTGHAKFTSKQAFERGLARGGSFLIILDEIDHLHTASASANLLQSLVTFAHTPNSSLTLIGIANTLDLMTRYDLASSASLVPSWKKGRGTLIDTPTMQQLHFKAYNASEIELILRQRLSMLADSYPRVPDLASPPAPSSRTTVPLLHPAALKLCAMKVAARSGDIRQAFRVVEMCVSSLKRKARGSLGDGPDAQTLLSSHTPETAPKASPSDINLSLKDVGLSVSAELASQLSTLQRNARFVLVSICIALSRESLAGFEAKALNRTVNVSSCYAVYQEMLELDEVFRRSANLSRGDWVDAQGLVEANAFVRSFSMQGAAKGRKPKGSPTRRSGADAADPMLGLSSYGLDEVVDALKTVPAAEGMSAGVLEDTLRISKMMLHWEEERVSRERNKKMFEQQRDRSRDQNAPSEGFHGLGLEKGPASVGAGKNGRKAQGASGLGKWIGKKRKVEDGDEADGNGLVVGESEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M829</accession>
    <name>A0A2X0M829_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="23">BQ5605_C001g00667 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">BQ5605_C001g00667</name>
        <name evidence="23" type="ORF">BQ5605_C001G00667</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY48589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M829"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0229">DNA integration</keyword>
    <keyword evidence="18" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="16" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="15" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="16" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="17" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="22">
        <location>
            <begin position="543"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="239"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="21">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="SGY48589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="718" mass="78100" checksum="8CDC49943A320422" modified="2018-09-12" version="1">MSSTGSVGGPGQKSESHRTTIGMDTDSPSTETSDRGLHVPILRASNYMDWRRRLIGRLGSKDLHLCASRPLSDAAKARLDFAAMDAKIAKELKKEVRTQAEIIQFLDEANLRLVRGCYTSYDILDSLNTFYLGTMSAQISALTTELYARKFSSGDRGQLLHHLITIQGILQDLEACGSGMPPAQQSTLMLDSVFDPQHESFTSSLRRPLALPSEIVSEARSYQFKVSLASRINGLSATTSGRAMAPSPVPALLSQGESQNAAPRAPLDLSSRAISCLSKRRLKKGNRDGQGNRRPTNSTCHACGAKGHWSCDAVCPEKRSKSSAAPALVAMNSHSVYLAGSSSRAPDADFVWIADTGAGHHFVGDRSLLSDFKESPIQVQMADNSLGQATGYGRMSVKTSQGHLLNFKEMYYLPGSKYGLISMSSLRAGGAKLVYGHGGDTQQVWLDGSLVAETVKTKAKQPSYVFDFEIVSPPSPVLVAATRASVGASLMEWHRNFGHMAPSSILQLVKSKAIVGIRLLDKEIEDCEPCIIAKARAGSHKHFSRKPGHVLQRVSIDLGFVNDDDTNGRSIYMVIVDQLSTYKWAFPLGSKSASEVLEVWRGFQAQVERQSGQKIKFVRSDNGGEFPTSAASRLPALSSQPCAAARVAAIAPVSDDEEQLRLAALDHRLRAEFADRFPADIPPVHLYQSPVRHRIELDTPSTVVNLRGYPLPKKYCEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M853</accession>
    <name>A0A2X0M853_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C007g04840 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C007g04840</name>
        <name evidence="8" type="ORF">BQ5605_C007G04840</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY63859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M853"/>
    <dbReference type="STRING" id="796604.A0A2X0M853"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050031">
        <property type="term" value="F:L-pipecolate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF46">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="13"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY63859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="440" mass="49113" checksum="CA268DD5657DAEB8" modified="2018-09-12" version="1">MSEGTPLQPPTSILIVGCGCFGASTALSLLRGRYSNFPQLITILDRSATPPEIDAASSDINKIVRQDYADPLYATLAIRAIDRWRKDRLYEPNFHECGVLVAARKGTKNEVYVRKSYELNKEEQRRSEAAEKKVWVLQGEGMWKEVYGRVPQIVRKKELESNTAYYNEAGGWADSRQAVVDVVSILRSSGVQFVQGEAQSLLYANDSRTVQGVKLIDGRTLTADLTILASGAWTSRLLPELGHELVPTGQVIGTIQLDEKEAELYRDAPVSLFLDTGFYSFPPTKTGLVKFAIHSAGFLNPTPTLPSTPRTTLSPGYETQQIPLSARTEMIEQLARVYPALQKRDWKGSRLCWYTDRRTGDWLIDYDPSREGLFVASGGSGHAFKFFPILGDLVVKRLEGSLEEEASKVWSWKGVEGRVDKSREGRETSQILEGEREAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M8R9</accession>
    <name>A0A2X0M8R9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C006g04045 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C006g04045</name>
        <name evidence="9" type="ORF">BQ5605_C006G04045</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY55566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0M8R9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024990">
        <property type="entry name" value="Apc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048971">
        <property type="entry name" value="Apc1_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041221">
        <property type="entry name" value="APC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827:SF3">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827">
        <property type="entry name" value="MEIOTIC CHECKPOINT REGULATOR TSG24 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21282">
        <property type="entry name" value="APC1_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18122">
        <property type="entry name" value="APC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 beta-sandwich" evidence="8">
        <location>
            <begin position="1675"/>
            <end position="1769"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 C-terminal" evidence="7">
        <location>
            <begin position="1816"/>
            <end position="1990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="125"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY55566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2042" mass="221757" checksum="44479DF10E9EC030" modified="2018-09-12" version="1">MLAFDVPRLDPDPFTLLGASPPLASTSTSHSRRDDGSTAATSTRSSYLDRLVQLSRRAEAPASSLSSSTHLFVASPQSSSTIEHLSWSGHRVVHSSGSSIARTYSFPHAVVRQAVFAQLPTRATNHEHSVNSSGASSSSSASRTTAAGPDRLAALFGPFQPAPPMPWTDDPLPLPLHPPEPTSENEQENFATQQVLERHLLVSLSTDELYVYPLAPTGAGPWIVPLTLAQHESSPPSSTHAPSAEENKMWSLPRDVLIETKGGHWHTLDDVKHSIKRIEDPELTTTTLRPHKIVQVLALNMDDHALLVTINTVESKLDVWSCTRSNLDRPKESSTKGKARVKSDLTARRSMILSGLEEMTHQDPAAIDRVGSKRKRNGSIAATAPRMSVGSSSLAAGASTSVNRRISFSAPPTSSYAAEANEEHLLMEVLAASGASGSVGMRRNATKASSAGLAHENRRTSLTRNELSVTMDRMALGQGGGSSQGHVLTTVNAITGDAGDRTWFNPVLGADVESLLEERETSEWVVEKKWGMAFSNSHGPYVSVFDDIQAFLFDTRRDKSMLAILLPQSQTLLYLSVDAHSVAPIRQTSATHACVVSHLRGNGVKDLLVKQPGAQGWRIAHVQGHDEPITFNGRIGEGPIRKLEGNGSGHVCVTTLDGNRSLVELPTNELLREDLTRTCLQALSLTLSTDQFVSLERKVRVTCQRDRSGAWAAFTAVLLRQGEVEVSGNHRDAATVIIQATNDAPNDPVLGVFRSLRSAKVAPSNARQIASPLDATEREDLKVVVATLHLVAEDLRLSTLKMDECKRLSQLVFSLAASLGLEEWVDVYRRSLGIPSDETAYSMFAARLFQNKFTTLISFMHTDVPLAGKLSPLPRSPPRVLDQLSILLRGTASSDSTLPLRRSWCTLSGIADQFGTDGAYFYNALKPHPVQTIDSLFQLFTTLVESHDPNKTPLLRSKPVVERMVELGIDAAALDRLALGVGMVLREAARACQSAAPAGMGEKAYELIRRPDLARQGRGPERDATDGHKELASLSGSTAIDQIAQTIKAGKATSLFLSSSQPSANRDDLAVSTSNAVRFNEDRRLEEVMRMLQFVEPVTIGGDRADRTLDQLTPQTQQLLLLYLSHRTLALPVGYAMFTYRTNSGPPTDAVTIPSINTSARILPLPSPVSLVEKEPRESGSPGHGERLEWPNFHAGVAAALQYQAASTTSSVGPMNDFGFDASHISFNKPAELDSKHAGFLFGLGLSGHLSKIAFNQVFEYLRMKHDPTSIGLLLGLAATYLGTCDPKVMSLLSVHLAALHPPNSSTLNVSGMTQAASLFGLGLLHLGSSKRTLADVMVRELCAIHVTTTEDAAACREAYALSAGFSFGLIMLASGTNAEATPGEVALLKTLRALVTGESHRPLPTPAGSTSKACHVTDINVTSSAATMALAFMYLRTERHDVASLLEIPDTPRRLDYVRADLLLVRTLARAMILWNRIQLSKTWVESHVPMFISQAVETAKQKGVAADADLEIARWSIIAGACFAIGLKFAGTAAAEAHGTLIHYLDRLTRAAYTKAPTVQAKIRRHAIRSCLSIVAVALSMVMAGTGEINVLRRLRVAHGHFGEGVTYGTHLASHMALGLLCAGSGQYTLGTSNTAIAALVISFFPAFPPTPGENRSHLQAYRHLWTIAVEPRCLVARDIDTGDSTFLPVRLRLVDPISTSTTGAQFEVRAKQLVAPTLIPELKLIQTIQVDTPRYWSFALNLTSPSSAHQREAFLSDHTTLWVKRRTGHLSYAQDPRGVRSIFTRSKSETGSAVLDFGRTVRLLSPSSAGLQEFVNSFSDDVEALAMVSYICDPSSTRYKPPTEFEAFASTVLLECLTRDKKDLVGVYHGLFHAKQLEKGHGKIWAQEQISFIVDLYGNEVFGTLFGDGKTSSTKRTTSKTGSTPSVKEKLFRSAFIDYLAQPPKPVASHVDDSSSSLRDYVLHGRWPSDPIQGQAFSLYLVHHRAPSVSVLKQLSQVVRTDRGNVELRLMTMRKILEERTGMPIWSDEFGKSLIEAWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M9P0</accession>
    <name>A0A2X0M9P0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g03944 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g03944</name>
        <name evidence="2" type="ORF">BQ5605_C006G03944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY54989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M9P0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY54989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="161" mass="16880" checksum="7C7F9090511DE430" modified="2018-09-12" version="1">MFSSNTISSSEQYDAYHPSPAPPSRPLDAPAVANIDYPTYSLESGSQASAFPYHLPVLGSTASTGYPSNRPSCPADSAANRLHHLHRLLPDPLQLPMDEANTSSGVLQSSPNFSSVDGSTPTMHASPLSAADQQFARVQVPVATVPTAVSPLTPAKRPMGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M9R2</accession>
    <name>A0A2X0M9R2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g03964 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g03964</name>
        <name evidence="2" type="ORF">BQ5605_C006G03964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY55094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M9R2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13975">
        <property type="entry name" value="gag-asp_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY55094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="360" mass="40757" checksum="9704203731794F2D" modified="2018-09-12" version="1">MTDCERAFLKSNRGCFKCQKINAGHLSDTCTTWATAACKVVSMTDIDEGVDDEGEQLHCLRNDEYDNGTDEERCEPIFLPVKLTNDDRPVLRALVDTGASASFITDREVEKLRLTRRKLQVPTSVSVAIQSHRVSHPVTEFVCVPLRTLNGRWSTQHVVLKIAPLMSLKLVLGRPFLKRHDMLVDCRRRQVLVPDPTLPDERIDLLTDRSASAVQAGVRACLARLEEQQAEGSYLRAMEAEFRREFSDRFPVDIPPVSQYESKVCHRILLKPGMKRPRQPTYGTPMRWRAAWRRLPDEHLAAGRLCASSSEYSSPAFIILKKGMDTDALIMPRWVNDYRILNAATVPDCTPLPCKDHSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MBS7</accession>
    <name>A0A2X0MBS7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">signal-recognition-particle GTPase</fullName>
            <ecNumber evidence="11">3.6.5.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Signal recognition particle 54 kDa protein homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">BQ5605_C010g06132</name>
        <name evidence="15" type="ORF">BQ5605_C010G06132</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.4" evidence="11"/>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MBS7"/>
    <dbReference type="STRING" id="796604.A0A2X0MBS7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17875">
        <property type="entry name" value="SRP54_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="entry name" value="Signal recognition particle, SRP54 subunit, M-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 54K PROTEIN SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF5">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="Signal peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="14">
        <location>
            <begin position="317"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="439"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="447"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="473"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SGY14295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="640" mass="69267" checksum="8AB7A89F2EBD35A8" modified="2018-09-12" version="1">MVLADLGRKLNQAISSLSGSSPIDETALDLTLKTVCTALLESDVNVQLVKRLRDKVKTIVLPPLVELQTRDGNQTDAVAGQKGKQLIHKTVFDELVALVGPGDDAPPAFNPKKGRTSVIMMVGLQGAGKTTTCTKARKQDLEILATHYTRRGFKTALVCADTFRAGAFDQLKQNAVKAKVPFFGSYVPGESSSLPFESSHLWESFPATHRYTETDPVSIALSGVTKFRSERFEVIIVDTSGRHRQESELFEEMVQISEAVEPDMTVLVLDGAIGQAAEPQSRAFKDASNFGAIIVTKLDGHAKGGGAISAVAATKTPIIFIGTGEHLHDLEKFSPRPFISKMLGMGDLTGLVEHAQEMANANPQRRENLMKKLEKGEFTIGDLKEQMATITGMGPLSKLTSMIPGMGDMMGGNADEAAKRMRRIAFIFDSMTQEELASDGSLFRPLKKGEKKKESTKTKPKSSNRATTSRSVKGKDKENASTVAKEEKKVEEKDLSEMEPREPNPRVLRIARGSGTTVDEVEELLAQHQMFSRMVKQAGGKTGWASRMRQQQMMAARRGGAGAGMRGMPPMGPDGMPDLSKLTPAQQERMTQMMGQMNPGMMSQMASMMGGGGMPRMDGAGGMPDMSKLMSMFGVGGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MDI2</accession>
    <name>A0A2X0MDI2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">BQ5605_C012g06817</name>
        <name evidence="19" type="ORF">BQ5605_C012G06817</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MDI2"/>
    <dbReference type="STRING" id="796604.A0A2X0MDI2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06609">
        <property type="entry name" value="STKc_MST3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000499">
        <property type="entry name" value="Serine/threonine-protein kinase KIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046409">
        <property type="entry name" value="PDC10_dimerisation_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048288">
        <property type="entry name" value="PDCD10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20929">
        <property type="entry name" value="PDCD10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="93"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="367"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="566"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="428"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="478"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="498"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="SGY16238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="659" mass="71870" checksum="25CC624F8DCD980C" modified="2018-09-12" version="1">MRRHSQQAPPPPPPPRDIRSSPYASRTMTSSLSSSSTSTSTNSSSPPSSIQSRSSLAFKQANGGRPAQESSIRSNQTGDSNAMIRTVDPLELFVKQQRIGKGSFGQVFKGFSRHTQRAVAIKIIDLEDAEDEIEDIQTEISMLSSLDSPFVTKYEGSWLRGTELWIVMEYLSGGSCGDLLKPGVFKEEYIAIVVKELLKGLEYLHGEGKLHRDIKAANILLSSSGEVKLADFGVSGQLTATMTKKNTFVGTPYWMSPEVIKQSGYDSKADIWSLGITAIEMAKGEPPHSQLHPMKVLFLIPKNPPPTLEGAFSKPFREFVSACLQRDPLLRPSAKTLLKHRFVKGAKKTSCLAELIERHRVWKLETSNGRDEEGDERGDSDEGDDGVSDDLWDFGTVRNGHSKAGGGGGTLRQTGPLPPRPPSFEQGRPSNAPQKQATQSAAVNSVKVHDYAQPSSRSLKSDEGAFETIRAGAGAGPSSLSERVLQSSPNGRGDKQKYSTVSSVSTYSTFAAEEEDPEAGFERERERMGRMSLQAGQVGGPNGEERWSGDGNGMGSMRLQAGMGTVRRSQQQVQQHQRDESGTEEESILYTVVLPVLDSIHDRITNDQARDSVLRLRMALEVAEKEAPGLINVLISEIVDSVEVCTGSQAIWGYGRRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MDM3</accession>
    <name>A0A2X0MDM3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C004g02898 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C004g02898</name>
        <name evidence="4" type="ORF">BQ5605_C004G02898</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY68562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MDM3"/>
    <dbReference type="STRING" id="796604.A0A2X0MDM3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000009">
        <property type="entry name" value="Carnitinyl-CoA dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000001">
        <property type="entry name" value="Probable enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF171">
        <property type="entry name" value="SD19268P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY68562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="302" mass="32179" checksum="4FC680F5D0DA81AF" modified="2018-09-12" version="1">MSTLITRIRPSLARGTVPSYRTTLVSRLPASWHAYSTAPNPDAEATLNKKNDGIALLTLNRPKAKNALSMQLLADMRSAIDEIRFDGKTRTLILNSSSSGIFCAGADLKQRKSMTQTQIARFLHDLRCMLSELSSLPCPVIAALDGAALGGGLELALAADLRVASHQATKIGLPETRLAIIPGAGGTQRLSRLIGLSNAKKLIFTARALNAQQALDMGIVNYLANEGQTATEKAEEVAKEILKAGPLAIRAAKLAIDVGSGLDLEAGLDFEATAYKTILTSTDRVEGLKAFAEKRVPVYKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0ME84</accession>
    <name>A0A2X0ME84_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C039g11771 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C039g11771</name>
        <name evidence="3" type="ORF">BQ5605_C039G11771</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000060">
        <property type="protein sequence ID" value="SGY89821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0ME84"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015862803" evidence="2">
        <location>
            <begin position="20"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY89821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="219" mass="24483" checksum="AF19E73FF7ACBEA2" modified="2018-09-12" version="1">MLTLPLLVASLGFCHSVVGSRHKNQDAHQVQGSTGKEPLIDADKMYLIRVNPQIPPRDLPHAYNFNEEIAVTGLQSACTFLSDRCEKYVKRGPNVKQLDVSCSSAGQAVTSTSPYLWASCFETGTNEKDGRARDVSFNAFAGSDHAIVFLRGDEVFREVEIDEDLLKTESKKWKPTVNHQPQNRSPRQAVHRQINHETTGPKTHSGHNGDRPKRHKQET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-11-27" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MGB8</accession>
    <name>A0A2X0MGB8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C034g11264 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C034g11264</name>
        <name evidence="2" type="ORF">BQ5605_C034G11264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000065">
        <property type="protein sequence ID" value="SGY99062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MGB8"/>
    <dbReference type="STRING" id="796604.A0A2X0MGB8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051924">
        <property type="entry name" value="GST_Kappa/NadH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943:SF2">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="1">
        <location>
            <begin position="16"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="1">
        <location>
            <begin position="264"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="1">
        <location>
            <begin position="400"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY99062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="541" mass="60716" checksum="62F6FD0C9AE8DCC2" modified="2018-09-12" version="1">MALATSPTTGFTVPEVVFYFDVVCPYAFIASERLPDVIRFTGANVTWKPVVLGALYGMTQAPQGKDGSATDVYAPAKRALAAVDFQRESKRYGLPIKFHPDHPVRSVDAGRLLCAFPNEHRGTLAREIFRAYFFDNANISSRATLLRIARNLKLTSVATPTHAGPFSLSPTLSFQLDESVFSDVNREDQLRANTQEAFERGAFGVPSFYIPSREKLFWGQDRMVLLEAELISIKLNKPVESIRQLERLHPRCLRTGRESRKRHLKFWFDFSSPWSYLAWSQFERIQRESGPGLTIELVPFLLGALFKGIGTPMVPMESMSEARRKYNMQDLQDWNRYWTAVNAQEYPPIEGPSMAWPDEFPIRSVTALRVALLEVKSSYTNLMTKNKVLILSIIIPLQPKTIPCLFRAAWRHNRRISDDQVVVEVLTAAGFDGKTLVARSLAAKDQLRHNTEQAQALGLCGAPTFQFKDQLVFGGDRINVVQDLVLGWSVTSLVLSPERSKLKASVAGFAHFDCKLPSPPCLGKVRAFKLTLDIFGPLGCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-02-22" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MGY6</accession>
    <name>A0A2X0MGY6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C033g11187 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C033g11187</name>
        <name evidence="2" type="ORF">BQ5605_C033G11187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000066">
        <property type="protein sequence ID" value="SGZ02098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MGY6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ02098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="189" mass="21305" checksum="C92364B48FBAF050" modified="2018-09-12" version="1">MSVQTPRPVRGPPRRHPLSSGRLPCDQLQGPVLRPQHRIIQPIRQPTFLPAGSFSVTEGHIEAIAALFELDQFGNRDRYDAVLVTAPTGSGKSVIFEAMYLIYGRRAVTIVAANLNRKGKDAVVSLEMHINNADWAKLISKDSFRERVKLPVYDEDRGWCASRIAKTEAKMRDQSSKRSIYLRFETGCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MH60</accession>
    <name>A0A2X0MH60_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C009g05431 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C009g05431</name>
        <name evidence="2" type="ORF">BQ5605_C009G05431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY80991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MH60"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY80991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="170" mass="19355" checksum="966AB0B87B3C0D47" modified="2018-09-12" version="1">MRDAHKPDLKLSWPPWSPCPWRLHEHVEKADPQRDGQVESIKVPENHVWGAEDDTTPLVSRPVREGGGGGGVKCDSSGLARSGVVCSKDHCADVVDLFPHANTPKTVETWKMDDATRKAWEAQHKRRIHDDRLMEDIHIVMELKVNELDQALADAQLYRRYYRMISTKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MI59</accession>
    <name>A0A2X0MI59_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C009g05582 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C009g05582</name>
        <name evidence="6" type="ORF">BQ5605_C009G05582</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY82605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MI59"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019441">
        <property type="entry name" value="FMP27/BLTP2/Hobbit_GFWDK_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019415">
        <property type="entry name" value="FMP27_SW_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019449">
        <property type="entry name" value="FMP27_WPPW_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045167">
        <property type="entry name" value="Hobbit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678">
        <property type="entry name" value="ANTIGEN MLAA-22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678:SF6">
        <property type="entry name" value="BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10344">
        <property type="entry name" value="Hobbit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01214">
        <property type="entry name" value="Fmp27_GFWDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01215">
        <property type="entry name" value="Fmp27_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01216">
        <property type="entry name" value="Fmp27_WPPW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27 SW motif-containing RBG unit" evidence="4">
        <location>
            <begin position="1419"/>
            <end position="1523"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27/BLTP2/Hobbit GFWDK motif-containing RBG unit" evidence="3">
        <location>
            <begin position="1541"/>
            <end position="1703"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27 WPPW motif-containing RBG unit" evidence="5">
        <location>
            <begin position="1995"/>
            <end position="2528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="711"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1140"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1881"/>
            <end position="1903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2131"/>
            <end position="2153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2244"/>
            <end position="2273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2342"/>
            <end position="2369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2387"/>
            <end position="2426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2848"/>
            <end position="2899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3078"/>
            <end position="3131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3173"/>
            <end position="3233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1154"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1164"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2137"/>
            <end position="2153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2252"/>
            <end position="2261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2408"/>
            <end position="2418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2848"/>
            <end position="2863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="3113"/>
            <end position="3127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="3183"/>
            <end position="3198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY82605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="3312" mass="370038" checksum="123DC650EA45A1FC" modified="2018-09-12" version="1">MQPGKDHLPLTLARSRPIARSHSSLTTLSKDTDETRSWSSLVVTVVAVLLTLRVLLHVLLALFVPRLRIRTVSALGLGGFEWHDPSGVVITVERFAWSIVGTNTSKKGWFILRCVGVEVRIPKRIVIEPPPPRPPRNTSGTPRRKARFEHPRDGPSSRQHPLNLNGSPARKDSVFDPSYSPPQTPRLDEDSDDVQQRSARRARKPRLSRLALRLVRHMLALVLAPIHLIVRRLTSLLTLFAVEIDLAVELEDVARVKCLVDVGGEIARPFVVRRTVDKHPRSSRHDIDREAHIGVWIAISGLKIHEVLPPKSTIPQTPTPLPAVEIQSLLLLSASTPFGPTGGLISLIKCRGKQWNAGRATVRVSLTIEKPRRARKDLDTGVHIRVYEGKALLAKVEDLLHERKQFLRRHPRPDRAVVGAAEELSKAQNSAKPKPTPLFFLRSFDAEIPLVVVSAHYHTPHHTLAACPKRQLPQAVAFALTIRKISARLRMSGSTDMVKREHAEWLGKDRVLGLGGTIGWGEIEGRVKVDGSAEDILPNSAKAFSIGRSSVTTTTTWLPPRLFESFAAHTPELVTYTSPRYFNDETVIIEGYIGEVRGHAKYETIDSALRIFMARPRSQYGKYTRTDLSSNSEAKVVRGAPRVVGHIAMAGIELRVQAPTSSSEDDIADDRDQFFREWACPDLFCLSIPNGTFSFGGEYEDRSLRRTEADRRLARRNEKYRSKRPGEPHDREASYKSVELRDKGMLTESKIPIKQHYADAPESTLSDVHDLRSLPMMYTARAHVAAETLNIYIIATDPIRGEGGTGSSECFLDQQSTLPSNTRRLDILAAGPVEITLTQQIKCSVKDDAQLGAIAEFNLHTLAGEHNILVEHVGIDLWRPIVMSCLRDFVSSWASASATKTTRAKTTDELGLPEPKPLVRSLPHNQCFYAAIGTFDVRLAGSDPKNDGQACRGIAVHCGPVVFEYLLQPKLRQEGAVNYGNRASLELAEDIRQEANALAMSHRDQALVKVAVHDWSIDPVVDARETLGHTRKYSMWPGMEQDGHEDASWELRNRAHITDLTKRRKTIMVHRPDKTVKRIAHVPILALRARIVEVKGRTPNGPLDEVIVSVKGRTGTFRLELFSIYLCLVAFSALRSLSPKHNPELSPRPPAVDPDVDEDVGSDEVEHAEGESSKADSAKRPKPLISLRGDVDDLNLFITLPHNVPLYLNLKRPCVQYTKQIGLLVEWDTGLLAGDSPTVLGKWDDLLRLRVTSLAVRPEPGNDGHRPFVISLSSETARMRIPFRYVYSRIIDNVANLIKATKQLVHQHVKGGMNFVLEPEAEAAKKLPRIELNIKMFAIEIQDDPFETRLNIIWRAGYEEQSARIERQHAFQAKLEAIRKAHEESGVPLKDDIHIDGCAQETPMARHGPNGHHTVSPKQALHDLLAYNSSHWVKRMRNAVAEQARREEALTRRLYGGKHNSKRPDSVLPVPLLPTSKSVPLARATLHNLQFTISRTSFADEKLPDFLHDVGKGLPRDTQFTLLVPMHVNVQMSEATIRLRDYPLPLLHIPIAPDAPDVAKTQTPKASWIMDMDLVIGEEIGSEESIRRVPVVIVPAHAAKSSTNLYSIVVPRTAMTTKTYAVPTIRVRSPYATRIGWGNSISPAIQDVAKVLDTITKQSPDPSDRIGFWDKIRLQFHWRVSVLFEGEGPVHFHLKGSRDPYSITGFGAGFVKSWHGSVKFLVGHQNPDREFFQILSDRYILGVPNLRDYVDNAATGLAQTNRDNAEYTDNNTTLNGLETGQYKFGADTEFVKVCARLVHGVRWGMGCVVERACTDKTCEKVECKGRTPFHRACRIWDFIPHWEVHTKTDRAIKPDGEVEDSFAGFRSDFIHFSISLTSPSTLDLPSCGTSPNPDDASSDHEAESFVEDVDKSNSLHFTPHAMAHFARWWKLFDGTMSLPIRQGKLFPSSQAPSKKFGKHCATIKYRFSLAPLFISHTYRQDAPEEWAKGETTALGIKAKIGRFNVDLHQREQESLVTHSDTMVTKQVIHKAFYLAEVDLDDVDLRAISATFSEPEKAQLAPLEEMNEGEQELPPLPLPNISDEDLAWVDRDDYVDISYSFEDEAPRVRMFPFITCPRLTYDRQIDVARWTPEEAEEEQRRHDQEGHKSGAGDHARYQTLELTHDERSEQAYPKSKFGREPSHTCLVGQAKSAIDIQIDAANARLEELQSQQKTPAIAHTGRELESRIAAITAIIARLKKVREAEVSAKRSPTGCNDDSSSTHPHEPAEDEGEELSHITSHFYSQWGDWENRYMFHNPSMHLTNASRQILLKYYHSSQDRKAFVYHLSATAIKFIRDLAAPAEDSKSKKSTVRQKGAKDTNDLTVRGASSSDVSASARRLLDDLLKSHVEEGKTPGSSRANSWAEGEDQGSRARQHQDDDHGDMELDPDAASLLLPERYTSKRAHFCMFIKPQIALTSDVDDKSTVILTAFRAQFKSFAVNDSEYPDDPINADVLHSTFATLEGLQAFCPQVSTRTKGLTKLTVPLETLIDLRVEPWGFDRIVPRTWASMRYDKFNKLRLGSSKAVHEQEAPHLWAPSMSHFRTDRIALKNDKLSVSANPTHFTAVYNVVTDLLLYSDPAHKRRNTKLEALVFTHDFTHLDGAIGVVSDLQYKVRSLAAMVLQYRIHLDEIDGEGRLEMFTYMTEAIRQASELTLLVESISRARSLSGALKPATSHAGLLFEAKAPELTWHMHDNADIPFAKFSVTGAEFAWTSKSDSSVSNRLVIKDLKALNSSPEHLFAEIIAKYHGDRDNNMAKVDVFAAVLWNALPPVGGISIVEQFELHLHPIRLQLEHHVGRRIMDYVFSQRRKSDEDGGDSRDHSEAESDADSISSGSQKQAQRSLKSKLSNNSLRPPSIAVHGNHSVDSLQLRRQNELAVNGSVSQLMSSSASSIHTGQRQLRHVSSMDVLSLATSEQVLDAEEMRARARLNRTFVLVDISPTTLCLTYKSEKSDHSRMFDLFDIVYKTPSMQYRSKTWSFLDLITVMRKDTMKSIWSQRSSLLGQYLSRAHRKLPLTEQRSAMSQGLKSKIKMPFRHKITAPSNHSMPVTRGPTSPLGRVRTASPNSQSHNGDYAAGDAEAAAEAVAEAQEVRGRGQQPEAIVAELELAEATAALVPFPQAQQHHILSDDRFIAEPEPMVPTPSSPGSTSSLSARSSRSSNLDRVRQLTHSMSEGRSSSHHSDSSSSSYPTHRPLRASISGISDQEKAHLLLGTCCGKLVKGQRSRGTCGIGKLARAWRGAGWRQMAALVSFTLSFFFNTHSISISPIRLLQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIE0</accession>
    <name>A0A2X0MIE0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C009g05662 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C009g05662</name>
        <name evidence="2" type="ORF">BQ5605_C009G05662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY83898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIE0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY83898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="274" mass="30605" checksum="D4BBCF0A22028492" modified="2018-09-12" version="1">MYPSISALRVGSRFELHLPFDKVQRHQGDFITIVPQSGKGHCPYNLLSLHLQTNPPQDQPLFSYQSKGRWAADRPPVSGHSFRIGGATLYLLEGIPPETVKVIGRWKSNSFERYWRQVNLIAARAMSGDVSQLSTPGGALLVQAYDQLEEFEIAFDELASAEGDFDLHCEMWDIEITYELAWFGLGGELSLQPPVFPPLLGLARGGAICAGWVAGFFAGPCREGIRPQAQTKAIYYILFMFINRDRHKRRSVGDCSSYYLADTRRSTSDQAPAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJB7</accession>
    <name>A0A2X0MJB7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C010g05934 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C010g05934</name>
        <name evidence="9" type="ORF">BQ5605_C010G05934</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERCC1/RAD10/SWI10 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJB7"/>
    <dbReference type="STRING" id="796604.A0A2X0MJB7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070522">
        <property type="term" value="C:ERCC4-ERCC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22325">
        <property type="entry name" value="ERCC1_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000001">
        <property type="entry name" value="DNA excision repair protein ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047260">
        <property type="entry name" value="ERCC1-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004579">
        <property type="entry name" value="ERCC1/RAD10/SWI10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00597">
        <property type="entry name" value="rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749:SF0">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749">
        <property type="entry name" value="EXCISION REPAIR CROSS-COMPLEMENTING 1 ERCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03834">
        <property type="entry name" value="Rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC1-like central" evidence="8">
        <location>
            <begin position="107"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="15"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY13657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="362" mass="38873" checksum="A5FE90B4B2BCDEAA" modified="2018-09-12" version="1">MRMPALVPLASALSESAPLDAMQPQARSHASTSGSGSGSSPAQAREAERNGGPAARAGSVANVRRGWPGGAGASASASASALTSATASSSSVNEGGRVVQRKSLNAILVNTCQKGNPVVTSIRNTPWEYGDIKADYQVGATTGVLYLSYVCHLIGGTVSLRYHLLHPEYIHQRIKGLAQSYSLRLVLMLCDVDNHQAATKELTKICIVNNLTVIVAWSTQECSRYLELYKQFERKAPDLIKERVDDSYMSHLTSALTSVKGVNKTDVTTLASNCLVSSQLKSHHTRILDADARLDGRGQTFRNIVTASPDALAALPGLGDKKVRRLRDAFEGSFVVTKKKRVDLMEKKSIADRMAEKGHALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-11-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJQ7</accession>
    <name>A0A2X0MJQ7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C002g01125 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C002g01125</name>
        <name evidence="6" type="ORF">BQ5605_C002G01125</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUP186/NUP192/NUP205 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY30172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MJQ7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021827">
        <property type="entry name" value="Nup186/Nup192/Nup205"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11894">
        <property type="entry name" value="Nup192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="464"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY30172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2181" mass="238943" checksum="B778A74855F3CCDA" modified="2018-09-12" version="1">MDRFVRLSSFLENCLANPDPSLVSKLQLKLERARPALLDLLDLVPKSSTERKQLEKGTFVTFFILARMNVPELRSFTYVATGTNYPAGPALVKDILFLADQLSISEHLAASLVSYAINAKPRAGRGRAESGLVVFLDERAALIASLHAIWRGALSADERLAASGLQRVFERETEELVRGKGASVNVDANDKNKRGTWVQKVVETIEHLRVQAAALRSKLEQPLAAGGAGFSSALVPAQGSTSAPSGNFADEVVEMRIQRYDDERRGLAQLLFFLGAARQINKDELLALARRVSTTEANDPAAVYLLVALLAALDCSDESSTEFFYPLFTDSAFVNSFNQLLQGKWAVPQLKAAVQLQWTIFLDAAARAVPNFETDGGEFVDALTWQALDAGVFGFLGRSVLAFKMDSESGEIWSTVGSDATTLSSGSTVEPWFQEHVTQQIEVLVLDILTNKISILRKLRNREEDVESTSHRGGGFRSSQRSRAAGGDHDEHPIVARHDLEAFFLLIATLYRGEPDSGLKFWEEVLEDGSMHAMTSRLSAFLRWGSECRPPAMMRAFYEMVASLASGPISATYAFEFLGASDNGTKNAMQASPTFSWSALFGALEFYHTNLPDRPMEAGANAEGVLGEMPPEEVPILRSFVRLLRQVVSYSDVARATLYDNQRHRPIATLFALLGRPIPIELKASLISAIAAFSRPGGTFGVDVARRTWTALEQSQILPTLAPSEGRDARGGAGLAMGRTGGCLRGPGPLSIEGGLFTELEEVEAPNKVYPESTAFVQLLNTLIHTPSTLEPLRRGVEIDSHTIPDNLGAPHRAPGIDPYLKFVIDDVLLKTGAREFADQRERWKVTDACLLFVEKCLASYDLGPFLAWISAGGQKASGNNASALTPLAHLTVHPGFEILTRLLSSGPLLDQILTIIIAGQDAIQNNLAGTPLFTSCMLRCMRIVKRSLELQAPFLEVVVPSIAETLLPLPQDKLNRLKTLSPIDQLLLYQSEAVVQIALLINCEEEDEIALLAVQVLATIAESPFFDVVQKFPEQSRVKLNRLVGLLQASPETLRILDGVIMRLEADIPESDLELGEPDGFGAGSIRQAIRSALLDLMLQNTQPGKTAPNIAHLLLGFNVRGRLEEMQIDDPDAADTQRTSLHVVLDLLAQNVSKETDVQMSILFRHPTFAAKCYRLIRQLCLHPYTSSAVSRYLRNREQFFFRQTQALPFGIPAASGGALGGVQYVDGKQLVTSSSAVCAILQSQAWLLESTALELNMLANSQDTRRQVELVGTLFENPTSGDAEISDAFDQDAFDQALPRMLEIFHALDFSWHDSIAPNEYRLNFFAELRFDACLKTDSTGCEVYDFGAVLSLLSAARRELQNRGMLSSSTQQEEAKRESKVILETLVIENHRREIQFARYHALRAWRSLLDITLTKSFHLLPSEGRHSLLLDLMSAILPPLAASETEQAISELLAGAAVLLMTKLSEEGIRVVFFESAEAVQSVSPERLHAVLRLILQAILQPGVSPIVRGNLYAVLLNYIQYSSKMASLSPSLAKTLGNGSVADDASILGSLAAGPHDDLISLDGLSSIGGGLSSRAKRNLLEAGNFSILHSAIERLLPVICRDAAAGHEVWRTVAFTALDALMNVAEEARASSRALSILSKQGYLQNFVAALKGAEVDLQEALKPDPESLNALYVYEAQMSFLIRLASTREGAEKLMDAEVLAKLADCDYLGARPVADTNSMGGSRSLRSVEYIARSLTRSRCRNFTDFEGFLPPASERHHQLLLPALQLVVGTLVSFGADTQIATRQALAFVRGQRENLLVALKDCANLQTVSSLREAHLIVTLLSIVLPSVSDEDLTTLSSFGGLHAALLNLSAKTCGPQDWVAGVLPSNETERDEDQTLVLGEFPYWADAFSIRLAKAASTGFRHDATIFSDKVETLVESLEAAILTYQSVATRKKPGTNAFRPVWAPSLSATEATLGSAGAFLRDTAMVLKTRLDDVTRLVGYLDGFDTTSLEEIEEVFSFPEEEGIDGSERRQRVLQELQALHATLRVKVTSSLRKSPRGSCLPLKPWRTHQTDFLVFLDLLELGLLLYWRHIAFFLDPERLASEAQSSRPEFGVGLAETLRTRSSTTSISPFDLPTLRDGVAKEFNERLSPLLAALEFNQKNVGSSWRNREQYVGVVARRLQSVLLLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJR6</accession>
    <name>A0A2X0MJR6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C010g06094 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C010g06094</name>
        <name evidence="2" type="ORF">BQ5605_C010G06094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJR6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY14185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="745" mass="81043" checksum="DF2873FAB4553F80" modified="2018-09-12" version="1">MATFADLLSFVFPSTRFMVDNTAEPEAPPPLTQRGPGEYFPPGLDLISACHDSSLVDRVLSALGRGFDKNGKLDLALPWTIDSAVVWGGYVIDSVEIALGRLYLTAIRGVSMLKAIGHERLSFDVSTENEKHHPLSVASCEYYLFRVPPDDGAPPRSPGPEDDEVSFTPVVVHGYMASDLKTYYDGITNASGVERPGLGAHLLDIRIVNATGELVRLEGARAIAAKVGLTFMGEAARLRCSRWVLSFLIISPFASQIALHATERGDRRFAIILALPYFVVIELGWYNFLRAFAGQAKLADVVASLTLLPLVVVIDGKRHLLISDLCSAVVEPEHSTAKSRSLMGVLLGTLMNDFDDYRVDGHSSEVEQQIRDYVKQLDELTVVNEVQSTDDVSPRDSMLNNSPPAQTSTAPSDEAAASTSIRRPDDTSDSSEDLKAFVNQGNQTVMARHFPKQAIVCDVKELPHSRMVAIPIELEMDTAPALSPQQPPAKKIRLDSDAHRPKLTEALSLAIQELFSPDAFFSKAEGTFSSPLASTLTSRLNLVRRVDRGASSSVWQAKCCITARAVHSSSITSANPSTPTPPPETPPHTSPRSLLDVRSTPDASPTPDLPSAMNGLSSAGIGGRGKLVAKVVRERFTPSIAREYFVYTSIVPLLSVKAQEYFPAFHGLYRSGNEGQAYIFVMKDAGSPITHKQLEADAELKAKVDFALKLIADEGLHHNDEGARNVLLRPDGRICLIDWGEAQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJU2</accession>
    <name>A0A2X0MJU2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BQ5605_C020g09132 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C020g09132</name>
        <name evidence="11" type="ORF">BQ5605_C020G09132</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000082">
        <property type="protein sequence ID" value="SGZ17598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJU2"/>
    <dbReference type="STRING" id="796604.A0A2X0MJU2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043337">
        <property type="term" value="F:cardiolipin synthase (CMP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF60">
        <property type="entry name" value="CARDIOLIPIN SYNTHASE (CMP-FORMING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGZ17598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="276" mass="30247" checksum="20B2F39A93EADC56" modified="2018-09-12" version="1">MLLTRSQIPLLQTSRTTGFQATTTRLYPCIRLFHTTALLKQPPIQISTPPKRNPSPTPPAKKDLYENIYTIPNALTLARIAATPVIGHFVLQGQFAQATALLFVAGVSDVVRRVDGYLARRYNMGSVLGSILDPAADKFLMTTMVVTLAMKSMLPPDLLVLSFSQVPLAILIIGRDVALTISAFYFRYKSLPPPKSFSRFWDFSIPSAEVKPTTLSKYNTLLQLILVGTTTIQPLLPFELGIGLVGLQSVLQRFVVAGTTIGSGLSYVFGRGVKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKP9</accession>
    <name>A0A2X0MKP9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C033g11165 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C033g11165</name>
        <name evidence="8" type="ORF">BQ5605_C033G11165</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000066">
        <property type="protein sequence ID" value="SGZ01798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MKP9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF6">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="97"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="688"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="787"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="948"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="693"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="787"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="819"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGZ01798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="971" mass="105594" checksum="F9C85F77E5865AC9" modified="2018-09-12" version="1">MSTAQSIRPAAISGDVVFIHDERRTTNKSCFLCRERRVRCDRTWPACKRCSNRREDCHYGPGVSVETKTDPGESVRVAELEAKLAAVQAQLYATQKGASSYTGPGHLQGTPSSVSSLNNGPGGQRHSGLFGTRSFSGSVSGSGSGVGSYSGNAPSSSSGRSGSDTGAAYANLNQPISMGHPEKLPSTILQTILPQASTQDKEVLMSFLFGQNRLGTASLDSRLAAPQLAQSLTLHLLDASQYCCCSKLSSFRALTDKLPHLKANLSSLSPVNQAAVAILCAIGARGSPHSALLGIDIPGLANGTAPPSVYLTVGARREDACRALADRAIDLCWYGRLIKEGSRENLEVLVGLSALLILDEVQPRKSRFILRNATGMFEDLQRSDNLDQRETLDMRQTLASALFRDDAVHAAQLNQPPLISSFELEEYFTCTDQRMPDFGGPQLSAILEQQLRTPDGEPLSLEALERAVNTVSVWVCFCQRTFARITTGRWFRRPRAPSALGDLATLWRKIDTVHSSVQRLQQFIVALTEPPPGSEGDPYVLDHYVLLAVRADTRLIDLVNLMHKFLMRPDLLDGWGGPPGANPVEIIQRMRIESVMRVRKVLKLSAFYAQLYLQSQDKHVVHHLFTQLELLPSWTLLALQRVGSPGGPTSEEFEVTPEELEWFAMGLRLAVYYTPRAAVRLHELTTGRHRKSSAVSSTGSSATPALDHSPNSELVSPFDSYPNVSNNNAQYAPNLQNGGAALGSIPPFPILPQADEVPSQLQFSLDDLQHFDIAPPPDLLHLEQQQYIQQPQQQQQQQHQQHQQNQRRHSQQESQRMQTSRPSPSSYFGTAATMASAQSGAPFTSQEPQQAPPAPHHAQQHGFACEPFPFASLRIANTHAGAGNGDGSSNPSGMRVDLPPSPFVFDAYGYPKKSPGLAADTPIAGSPGAQNAFKGQSWMDAAFTRHFEELEMPSRAGNGGNGRNGGRPSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0ML58</accession>
    <name>A0A2X0ML58_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C031g10972 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C031g10972</name>
        <name evidence="10" type="ORF">BQ5605_C031G10972</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000068">
        <property type="protein sequence ID" value="SGZ06820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0ML58"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018823">
        <property type="entry name" value="ArAE_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018820">
        <property type="entry name" value="BRE4-related_DUF2421"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994">
        <property type="entry name" value="ARAE_2_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994:SF1">
        <property type="entry name" value="ER TRANSPORTER 6TM N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10337">
        <property type="entry name" value="ArAE_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10334">
        <property type="entry name" value="BRE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="845"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="876"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="899"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="925"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="989"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1020"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="domain" description="Putative ER transporter 6TM N-terminal" evidence="8">
        <location>
            <begin position="122"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="9">
        <location>
            <begin position="869"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2421" evidence="7">
        <location>
            <begin position="1008"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="464"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1257"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="515"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="542"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="559"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1257"/>
            <end position="1269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGZ06820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1281" mass="142930" checksum="E3DE1FB99B5F29B0" modified="2018-09-12" version="1">MRSGSHARFNLGEDEEQHSGSEIDHPQPGMNAPQIVVEAVGDERGRPGVDRMKGEDPSEHTSGETMHEAQTGQGNDEKYPPAKAEADAAQGTGAEAATKPEEKPHHTLLHVVQKAIDPYIGWAKPKMNWKSWRPVFRASIASWAGLTLMLASRSQVMLGQASFLVLIVSVISPAAYPIATMLELTFFQFAIVSASWAYSAFGLYIAHISRRKYRCSQAQFQATVGQEFAAQGVAGYDISNRVLLEIFHGRYLEPTSSVVCGIFLGVGVGFLLWLRQRLGPGPALFGIIFGIILMIICFTIAVLFPYYYASVGLVFFLPFTCQQAIQLATSFLILPETLGHQFADRLVTTLTPLQGVIKTQKDMLATDPRSLDWLKFKTIKSGVQGAMGALALLGASEANLTREVSYGRVSGKDLIKLLKGVRTLVARSTGFISFYEIVEKHLHRDLSQAKGGAIADELVIHLGHSRPATPSSSRPPSPKPGKPQEQNQQHEIETSDDPDQLSRALAKATNETHSRRASAYRSHSHPGFTTSSRNSSSASIGDLHEGIVDNHQSHSRPSSSKRRSKSRTRLHAQHHKNKSSASLLHEILHPNVEIPRPVGMFESQRYMDLEDYLHNPRDEEHLREIMELLAVASIDLLDALKDLVSVLIEMIHAFKLSSHIVWRLLKDLGMRKTDQKTQEQLMEELGACIERVEMAHSHHRDVRRLDVIRPFAGLFDPISHLGPDGTIADDTFQAPSHRGLFWALSYQFSLISWGEALLDLSKECHTIGKKRQTVRLWTPEWAKFHFATSHPEATFEEESPDSVEVINRSVFRAPRDPDHRPPRTALALFGVKLNHFLQFFVRKEFLFAVKLAIVIGVCAMPAFFRTSCYFFYRERGIWPLVMIALTSTLYIGDTTFGFIIRLVGTVAGAIFGLLLWSIAAQTAGGNPFAAGAVMAVAMPLIFFFRLYYTPVPTAIIPTVTTMLVFGYSWQGAHHPSGSSVGSGWPVTWRRMVCVALGVIIAFLVAFIPPKVTQKKAIRKTYASVINSMGGVFCQIVSFAACKEDGSGARPTIILQNLAALRTKVSKTTASKMMVRFEWSWAGKWPEQHYASLQSLQMEMLDSFGQLLSVLASLDKKWTKAMLHRSQLSNPQFLGDMLTTFQLISSALMDGTQLPMIYNPLLERFLKSPETREAHRQYGFDIALNEEDEVEGIPSHVTLETICSIEYLRFSCGISQVYAIVNRLDRLMFITKDLVGEHYLMYGLDSLNYKPRQHEGDEERRWLRGHHDMPSGRSSFDAGEMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLC3</accession>
    <name>A0A2X0MLC3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C030g10776 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C030g10776</name>
        <name evidence="2" type="ORF">BQ5605_C030G10776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000069">
        <property type="protein sequence ID" value="SGZ08177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MLC3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ08177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="124" mass="13635" checksum="14BB9EFBCEAB93BF" modified="2018-09-12" version="1">MVRVRRQAGGVTYGTYPAPGRLSEPGVRGLGCTHHPRVSSRKINHLPHPNTSKHTERYTRKVAIPFPRSRTPLASDRDIGGEKRVRREGTRAKDSARLSRKFDESGREKAKIGASSAPGTSCCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MM09</accession>
    <name>A0A2X0MM09_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C012g06959 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C012g06959</name>
        <name evidence="7" type="ORF">BQ5605_C012G06959</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MM09"/>
    <dbReference type="STRING" id="796604.A0A2X0MM09"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF37">
        <property type="entry name" value="BB IN A BOXCAR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY16711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="494" mass="54497" checksum="099C5E4569EEDD92" modified="2018-09-12" version="1">MGIYIRNPTALLKYKYSSTDKSLTSKYVLNPYWSWLVTLFPESMAPNAITLLVRIRTFAAFPPGLGLVFANFLSLVYFNPTLSCGAKPLHVSLGGAWDPLLAPAKLTEQHHFRGWASWLGLGGSVVDKADELAGNCAPRWLYWTFAAGLFMYQSLDAIDGKQARRTGTSGPLGELFDHGCDAINTTLGVILTASALNLGLDWWTVAALIATSANFYLTTWEEFHTGNLFLSAFSGPVEGILLVVGVFIATGFVGPSYWDQGILTVTGLKSSAIIKAIPFKLKDLPMNDCFIVFSLVGLIFNIASAARNVYASLPKKGRTPASMLKPLSRLSPYIIHTSIMIFWLTGRKADILHSTLLVPFMFLWGISFAHHVQLLILSHLTASAFPATWKHPLIFIALVGAVDANASWLTNGRYTTYLQTTHERTKWTVLGGLVLAIMVYAHFVWEVIGDICAFYDMNCLTIKKKEKIKAVEYGKTVMKNKPSPAEIAKQKQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MME7</accession>
    <name>A0A2X0MME7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C029g10630 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C029g10630</name>
        <name evidence="1" type="ORF">BQ5605_C029G10630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ14953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MME7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ14953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="62" mass="7325" checksum="037AE0DCE65E2A1F" modified="2018-09-12" version="1">MLRIDWNRPNWARQSRSRTKEFGAWACAAFSSESGVETVHPELYWLVRRLDGFDRPSDLQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MMV6</accession>
    <name>A0A2X0MMV6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">BQ5605_C026g10210 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BQ5605_C026g10210</name>
        <name evidence="16" type="ORF">BQ5605_C026G10210</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ27870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MMV6"/>
    <dbReference type="STRING" id="796604.A0A2X0MMV6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="15">
        <location>
            <begin position="54"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SGZ27870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="291" mass="32851" checksum="24966DF4036A6A0F" modified="2018-09-12" version="1">MLAIAFASLYSWHLFFNHISQLSLLALHRAGAVTGLRLTDTTVVDCESCILTQMTATPHNQQSRGADHVLYRISMDLGFVNYEDFQGRSIYLVIVNQFSNTKFTYPLVSKTAAVVLEAWNSFITYAERLTGQKVKFVRSDNGTEFVNRLLGDEFRRLGITHETTARYTPQHNGKAERANRTLFDSFVQCSSTLRKTPYEPYTGHKPDVSHLRTFGSTAYALVLPRVLRKKLSNHSQKGIFLGYSGEYVNTTISSFLILAISSSNIFTSTKWFLSFDLIKSLSNLRTISTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MMY9</accession>
    <name>A0A2X0MMY9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g02157 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g02157</name>
        <name evidence="2" type="ORF">BQ5605_C003G02157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MMY9"/>
    <dbReference type="STRING" id="796604.A0A2X0MMY9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052925">
        <property type="entry name" value="Phage_Integrase-like_Recomb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34605:SF3">
        <property type="entry name" value="P CELL-TYPE AGGLUTINATION PROTEIN MAP4-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34605">
        <property type="entry name" value="PHAGE_INTEGRASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY39151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="167" mass="18657" checksum="30AD454991CA1B0C" modified="2018-09-12" version="1">MYPSISALHVGPRIELHLPFNKVQRPCPYNLLSLHLQTNPPQDQPLLSYQSKGRWVPLTRSRFLLRVNQTLKAADCPPVSGHSFRIGGATHYLLEGIPSETVKVIGRWKSNSFEQYWRQVNLIAARAMSGDVSQLSSPGGALLVQAYDQLEEFEIAFDELASAEGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNF3</accession>
    <name>A0A2X0MNF3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA replication licensing factor MCM3</fullName>
            <ecNumber evidence="11">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C027g10388</name>
        <name evidence="14" type="ORF">BQ5605_C027G10388</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="11"/>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MNF3"/>
    <dbReference type="STRING" id="796604.A0A2X0MNF3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008046">
        <property type="entry name" value="Mcm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF46">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01659">
        <property type="entry name" value="MCMPROTEIN3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="311"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="686"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="700"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="745"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="759"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGZ28614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="871" mass="95328" checksum="0C0CABCE3CAF1BCA" modified="2018-09-12" version="1">MADTPYNFELQDDQLAARVRIFVNFLDLDRNDPLARKMTIDYRQAIIKMTQKKERRLIVNLDDLRDYDRDFCNGLLNEPAAWQPAADQALKDCAINAGSASLRSETFYVGFSGSFGDNHATPRTLRADKLGRMVCLEGIVTRCNLVRPKMQQSVHFCPETKVFHSRVYVDRLSAAAAVGAPISATTYPSTDSEGNALEIEHGLSSFMDQQMIMVQEMPERAPAGQLPRSVEIVLEDDLVDRCKPGDRLQIVGTYRSLGGGAQGSATFKTLIIANHLVLLSAKAGAGAGIAQTIITDTDVRNINKISQKKNVFDLLSQSLAPSIYGSDYIKKAILLLLLGGMEKNLVNGTHIRGDINILMVGDPSTAKSQMLRFVLNTAPLAIATTGRGSSGVGLTAAVTTDKETGERRLEAGAMVLADRGVVCIDEFDKMSEVDRVAIHEVMEQQTVTIAKAGIHTSLNARCSVVAAANPIYGQYDVHKDPHKNIALPDSLLSRFDLLFVVTDDVDEQRDRLISEHVLRMHQYMQPGLEEGAPALDSLEQNLSVGAGASTNTEHVQDTPVFEKFNRLLHGGVTTTTGKGSKKRKEVLTMAFVKKYIQHAKNNIRPTLTKGAQDWIVRVYTDLRNDDLASNQKRTSPLTARTLETLIRLSTAHAKARLSATVDQTDAVAAEEILRFALFKEVVKPQSKSKRRKLVNRGSGDEDSSSGEEEDEEEEEEGDGAGQQRMEMPRRGTPARRQPGRKASTAPANSPRATSVSAPEYDDTQMDDDDDDTQTQPLSQTGPSAEAAPPVVEDGGRDAARARLFRTRFAATRKQHYNGVDEVVLATFLQTLNQGLTIDEVFSSGEAHTIMAEMANAANAPLMVDGGVIFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNF4</accession>
    <name>A0A2X0MNF4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C014g07489 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C014g07489</name>
        <name evidence="1" type="ORF">BQ5605_C014G07489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY18839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MNF4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY18839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="35" mass="3867" checksum="732AD69D5DA208FA" modified="2018-09-12" version="1">MVSPAKPVTLRSTLRLTSQDVLQGRFPSTPAVLWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNT7</accession>
    <name>A0A2X0MNT7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C022g09418 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C022g09418</name>
        <name evidence="2" type="ORF">BQ5605_C022G09418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MNT7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ22035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="121" mass="13026" checksum="918D084B25B72632" modified="2018-09-12" version="1">MVMRCRARARPRATERGPASDGRSRGECDGSVQRLVPAACTSEPGVRLRCGPLFGQSSAGAELCFAGLAMKVAEALMASERTDDVGLGRGPKGRRRVMIRVGARVWIEIARVEGGKIRQRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNV0</accession>
    <name>A0A2X0MNV0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C051g12520 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C051g12520</name>
        <name evidence="2" type="ORF">BQ5605_C051G12520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000096">
        <property type="protein sequence ID" value="SGZ29497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MNV0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ29497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="528" mass="58587" checksum="998B40E7AC5CB49C" modified="2018-09-12" version="1">MAYRRSQHYFRDNWVLLATVCYSPSARSLFPILYSVGNHDDRASTADILRTYSRFLTMPIIRGGHCQRSHICCRLFSAQIRSSPSHSDWYVARKTGRCGTLERHTQSGVTVDCRGYSDWREGGKRRERFAMLVNTMRNAKSHASIESIAKRTIDEFPVSENWIKWWTRPAIRNVVFKELNGSAERCVATTTNAVESSHLLLIHSCGGERFGPVEGSSTYHEQGNVRAHIKEIKSRNWVPSSYVSDANMPEPSISFAAPARLAGIGFSESPQGPSDLSKGPATPPLSESTKLPPSTSNRSRQQPKNRSRQGNGPTAQSMASKKGSTRVDYPHKRKIPDPPSDEHSSSESSDDVGLTPSIHCNSSEAIPPTDRSIKLHQTSNSKSKGSPPHSDFSGPSRRVPVVPMAVRALNEETSCPKYFCVAQCTKLEAPSGRKYRIPRNRLAFLLSEPESQSEAKRTFTSVEIATPKPASTLTSLERTSAKLPEDSRSAPRVKFAPPKTSTSTSLGSTIVQLHADFLLWIWTWSTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNX4</accession>
    <name>A0A2X0MNX4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">BQ5605_C022g09458 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">BQ5605_C022g09458</name>
        <name evidence="18" type="ORF">BQ5605_C022G09458</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">RNA-dependent helicase required for nonsense-mediated decay (NMD) of aberrant mRNAs containing premature stop codons and modulates the expression level of normal mRNAs. Also capable of unwinding double-stranded DNA and translocating on single-stranded DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MNX4"/>
    <dbReference type="STRING" id="796604.A0A2X0MNX4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21407">
        <property type="entry name" value="1B_UPF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18039">
        <property type="entry name" value="DEXXQc_UPF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21400">
        <property type="entry name" value="ZBD_UPF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.230:FF:000003">
        <property type="entry name" value="Regulator of nonsense transcripts 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000097">
        <property type="entry name" value="Regulator of nonsense transcripts 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040812">
        <property type="entry name" value="UPF1_1B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018999">
        <property type="entry name" value="UPF1_CH/ZBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF364">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18141">
        <property type="entry name" value="UPF1_1B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09416">
        <property type="entry name" value="UPF1_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51997">
        <property type="entry name" value="UPF1_CH_RICH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Upf1" evidence="17">
        <location>
            <begin position="134"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="19"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="C3H" evidence="15">
        <location>
            <begin position="142"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="CC/SHH/C" evidence="15">
        <location>
            <begin position="156"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="C4" evidence="15">
        <location>
            <begin position="202"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="945"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1092"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="955"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1105"/>
            <end position="1118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="SGZ22232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1118" mass="123681" checksum="5CCF060E52CFE7BE" modified="2018-09-12" version="1">MSAYGFSHLDGASAYSFNPNDDTTSVHSSALTEHTAQSQAQQQQQQQQQQHLSASSEAVASGANTAQNHGHHHPGSNGHHQQLELDFHSLTLDDLNGRPTGEASSSGGDTNDLDPNAVANLYDDDFAGMLDDLNRELPPHACSYCGIHNPACVVKCLICNKWFCNSRGSTSGSHIVNHLVRAKHREVTLHAESPLGETTPECYACGAKNVFILGFIPAKSDTVVVLLCRQPCAAMQSSKNIVWDTTQWSPLIEDRSFLSWLVKIPSEQEQLRARQITFHQINKLEELWRDNAEATLEDLEKPGVDDEPQPILLKYEDAYLYQNIFGPLVKIEADYDKRLKESQTQEGLVVRWDMGLNQKRIAWFNLPKLESGEVRLAVGDELRLKYHGELHKAWEGVGHVIKVPNNVSDEIALELRRNDGVPIDCTHNFSADFVWKSTSFDRMQLAMKTFAVDEQSVSGYIYHKLMGHEAAPPQVLRAQMPKRVSAPTLPDLNHSQIFAVKSVLQKPLSLIQGPPGTGKTVTSASIVYHLSKMNPGQVLVCAPSNVAVDQLTEKIHQTGLKVVRVTAKSREALESSVSFLTLHAQVANSDTHVELQKLIQLKESQGELSSSDERKFKALTRACEKEILGSADVICCTCVGCGDPRLAKFKFRTVLIDEATQATEPECMIPLTFGVKQLVMVGDHSQLGPTIMNKKAARAGLAQSLFERLVLLGNRPIRLQVQYRMHPCLSEFPSNMFYEGTLQNGVTAPERLRKNVDFPWPQPSTPMYFHQNLGQEEISSSGTSFLNRTEASNVEKIVTRFFKSGVLPSQIGVITPYEGQRSYVVSYMQFNGSLKKELYKDVEVASVDAFQGREKDYIIVSCVRSNEHQGIGFLDDPRRLNVALTRAKYGCVILGNPKVLSKADPESLFLPQHALWHYLLTHYKEKGCLVEGPLNNLQPSMIQFSKPRRPYKASENSKRFEHSARDMLDGDRNGLGVPSRFDSSFFRTHDALSSIPSDAQSVRSQATYSSGMPTFSQAGSAYPGSIKRGASSYASSTLSQDLHSHASDTASVRDDVSSINGGTAGSLAFSQADRLRRDEEFEASSAYKSLGERAWSSHGDDDDASSQYTVSAAGTTEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNZ5</accession>
    <name>A0A2X0MNZ5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C051g12547 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C051g12547</name>
        <name evidence="2" type="ORF">BQ5605_C051G12547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000096">
        <property type="protein sequence ID" value="SGZ29589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MNZ5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="1">
        <location>
            <begin position="285"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ29589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="399" mass="44396" checksum="F4A33E18137B7B49" modified="2018-09-12" version="1">MPRSQGRQGGPSQPRQVLGARVAPYHGLPWACSSARCWAPRGSTLLFPHVSIRNDLGPQTAVCTHCKARHWELGPPVFRVFGRLYHRLGALIPAVNQCPAFAQTWLIDPAEATDTRLGPDGADSRMQRSTLTKLESILRTGNRFPGPTHPQPSYVEHGNDDAYLRFRHQHGRSWTSRPYSLARSIRLPCLSGSHYYFLQGKMGPTPTFLFAGFAKLGCQSPETESRSAKVSNRGRYMPVSVLLTKAKRRTKTDNEDEDGGGQRECVPSWKNLHLTTTQGINGLTPNQIGRSMTLGSTFKNRPRDIAWQRYQDAMACVVKHGKPPLLITMMYDPKAPEIKAALGLNDKACNRPDLIAQVFEAKSGNKRHAGCFSDECRMNGFVSLLYFVGCFLNLCAEIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MSE7</accession>
    <name>A0A2X0MSE7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C110g13211 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C110g13211</name>
        <name evidence="5" type="ORF">BQ5605_C110G13211</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000104">
        <property type="protein sequence ID" value="SGZ30183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MSE7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="230"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGZ30183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="296" mass="32441" checksum="37A87F0F61A3F953" modified="2018-09-12" version="1">MPSGTRDGPPHTDNVARRVKLELPTLNAGFKSRDNYGGKIAAVHLIREAGCKMEGEGADWYIDCRNKVKALKSWPEFAQEVKARFINEKTGLEAKHAFYNAHQTGTLSDFVATLIAARGQAGSIGGTQVISDELFKDHLLHRCDELLYLCATASPSFDVTKFTMNQLVAYLQSLWEAITLERATTGVRRMGLRNDQVRQEQNNSAAHQTSGRPMAGLDRTPRDKALHEGRCFHCDVHGHIAADCPSKPGTSLTPAPSRPTPGPRMVAAIRVPGDDARWLAFQTDKEDACSFGLEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MTA8</accession>
    <name>A0A2X0MTA8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C002g01357 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C002g01357</name>
        <name evidence="1" type="ORF">BQ5605_C002G01357</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY32384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MTA8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY32384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="321" mass="35446" checksum="5BB974B9A4F2BD50" modified="2018-09-12" version="1">MTTMQPILALRHVYEPAVQLCRTDSVVSAMANSTLGSPHHHLLRKGECAGLESRSNPSSPTHFSACCSQGKVRLPPPPQPNLEYRQLLQGSDSDAKAFRENARSYNNALSFTSLAAHWDQTQVGTLGPPVFRVFGRLYHRLGALIPAVNQRPAFAQTWLIDPAEATDTRLQGPDSAETRIQRSTLTKLESMLRTGNRFVREFASAKARAGWDTAKEWVLRLCLPPGRDRCTHNLPTSSTEMAMLICGSDTNTGDRGPQDLILQVHGDRCPDGRPKYQIVSSLHPSAMPLRYPLLFPAGEDGFHPNIPLCGFHQARPPIARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MTK2</accession>
    <name>A0A2X0MTK2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C002g01457 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C002g01457</name>
        <name evidence="3" type="ORF">BQ5605_C002G01457</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY33158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MTK2"/>
    <dbReference type="STRING" id="796604.A0A2X0MTK2"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
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    </dbReference>
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        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="22"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY33158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="196" mass="21764" checksum="9F47B2B27D4B6B00" modified="2018-09-12" version="1">MMTTNEAAPSTVTPTSSGSKQFSVRLARTPEDLAKATALRYNVFCVEQGYPLLIERDGKDDVSDQLLLIDQETEEVAGVARWIATTCKLGRVAVSKAYRGTGGGEFSRIRKTCCRVEWPYLSGRILVLGLEDHLKSREGRAGVENRDKSECTINVSSQLPAISFYTRLGYEIEGQPYEEAGTPHVYCKKVVRLPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MUQ2</accession>
    <name>A0A2X0MUQ2_9BASI</name>
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        <submittedName>
            <fullName evidence="23">BQ5605_C068g12847 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="22">BQ5605_C127g13341 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">BQ5605_C068g12847</name>
        <name evidence="22" type="synonym">BQ5605_C127g13341</name>
        <name evidence="23" type="ORF">BQ5605_C068G12847</name>
        <name evidence="22" type="ORF">BQ5605_C127G13341</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000025">
        <property type="protein sequence ID" value="SGY27571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="SGZ35025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0015074">
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0006310">
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
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    </dbReference>
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        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
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        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR050951">
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    </dbReference>
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        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
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        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0229">DNA integration</keyword>
    <keyword evidence="15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="12" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="16" id="KW-0862">Zinc</keyword>
    <keyword evidence="16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="20">
        <location>
            <begin position="422"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="21">
        <location>
            <begin position="1542"/>
            <end position="1714"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="19">
        <location>
            <begin position="1857"/>
            <end position="1918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="483"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1292"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="42"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="484"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="512"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1299"/>
            <end position="1313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="SGY27571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="SGZ35025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1920" mass="213241" checksum="EEE2EF75B5368FC8" modified="2018-09-12" version="1">MAEPTDTSRDTTAPVREDPSRANPPKSPPTHSPHPLQAAAVITSLESRLAESEALRRDSETRIRKLEQMVERLMRESTAPAGAQVGEALPVRPVPLDVPPHTFLGRPGAAADPLARTPGGESHSGIRDGPSSAVISSRWRGTLPDREGLWTGDHPERLVIFTAFGESYLSLLCDISTSDLFDTSRVIQLVATLFSRTTTRQRRQSPLDWAVEAMRDALGEGRPHCWTSLMKAVGRRWPDPGFADRVAQDFHGCRQSSSRAYDHVGEWRARYRAFVHDNDSFTLSPLQLATTFYQSLSDSSKREVRAGMLREYHDNSLVTIGRFGLKVPSIDEITEWAAIADDISPPPSVPTPPSRTATYGAIVKAPRVSPPATNTPTVDERFQIRRARWVDRATKWQQSHLWKDRSTWFSPAPSGVPTSMACFNCGRGGHFSQHCTAERQSPVAVQLSAVAVADLDDEDWSSVAGGDEDPEVRVPISLERVQTRPLSSVSASMTRPSCPPADPVGRMKEGASSSVDVEVSSSNPQPTAPASDADLRRLADDSTDSAFDAVEDVPSYADAASRMRRYWGPEVVSSRKAERTASVSSVRVPVPLGVSLLESDTPLIDVDDFARPAEPAIVRARNIIAWTLPSGRTLRCLVDSGSEVDLVDQDVVRTDPSFTTSRLTAPLHLRLGTRDKSDRCAVFANALFTSGSLDLGLRAFFICRVTAYDAILGLPFLKDTGMLVGWGVFTVARPGPSQPVAKGTHEWDRAVTVAPICSGSAIGYDHPGLLPDDEIIGLEPHNPLLDVVDDPALEDLSESEARTRLAALLEKYSDVFVDSLPMDRLPPYRPVNHEIPLIDPNEKVKPRVYPLADKYRSQWAEHSAKYTRGRFWVSGPIDSAAPVFAIPKKNSQTARFVIDLRARNSNTAKRFSPIPDMTSVRYEVARSRYRSKFDVAAAFEQVRVIPEHVDRTGFATVTGTYTSRVMQFGDTNAPNTLNLLTSAMFQPCLSFAKIFFDDVHVHSDTRRAHLRHIEILLMTLRHYRFYLGSNKSEWFSKSLDSLGAIISDDGIEVDPAKWERIRQWPTPHNKTDVQRFLGTVNWMRDHLPHLSITLEPITALLAQSTSWRWNEHEQQAFDTVKSLVPATLRPIDGAKVTSGEHKIYLFTDASRVGIGACLASGPTRSQAVPTRFFSAKFNGAQLNYHVTDKEFLAVVSACRAFEQHLIGYPFVIVTDHQALRTIKTQKLRQTPRHIRMCLELSRFDFEFEFIAGKNNSLADSLSRLWEVKEGSPEDQVKENELEDMFFDGERHGFTTHGESLPEERPYTSPSHDRLPPVDCAFGPWDHGYDAGSPGSHRLAENIMDTVDSSTGPLSPPIAVNRVQAIAAAPANDAPIPVDADADELDLLGAAADEVNDAPVVHRPPDPLPQPFLDAVIRAYAHDSQAQVIVDDPLSWPMFRVTEEGRILRVHPDESLSLFVPRGLATGVVDSDKVPSLRELVLAEIHRSVGHAGHRITLAAIRPLYWWSSMSADCAKFCHSCEDCARGKASTQVPYGRLHPMPIPSGPWEQVAIDFMTGLPPVEFEGMMVAQIMVVTDTWGKMVRLIPLPADADSELVADRYYATIFRLHGTPSAIVSDRDPKFTSQFWRALQAKVGTVLRMSTAAHPETDGSSENRIKMVTQTLRIMVSSNHEAWASRLVEAEFALNSSVAVSTSLSAFEATYGYLPRRWPTDSWSVSDVPRAEAFARIRQLRNLDVTDAIIGARLDQTHQANKHRRPDDPAFRTGSYVYLSTKNLAVPEGMKSKLLPRYIGPFRIRAAIPATSSYDLELPPAMSRVHSRFHARLLRPYVENDAERFPGRDPAVLFVEDVADAADNSAIPEQIVRDRRNARGNRSFLVRWIGRKDIDDTWMSEQSLRFDHPSLLDTYLAQLDRSNRRLSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MW17</accession>
    <name>A0A2X0MW17_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C003g02399 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C003g02399</name>
        <name evidence="5" type="ORF">BQ5605_C003G02399</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY40606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MW17"/>
    <dbReference type="STRING" id="796604.A0A2X0MW17"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052735">
        <property type="term" value="F:tRNA (cytidine-3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026113">
        <property type="entry name" value="METTL2/6/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809:SF11">
        <property type="entry name" value="TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="393"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY40606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="482" mass="54204" checksum="D446C633B9563CE2" modified="2018-09-12" version="1">MSFSQGRITRQLGHLTPLTRRTTTLSTPGMASSIVASSSNSIASSSASRKEQPPRVRRIGPQLLADELVAEELIAGAPTVKGGRELTTDRDPWTHNAWYVLNISNMPTCSYQLNHFPFIRDKIPWDREQQEQAQAAIERQKFDAVPVELQEQYNADPAAYWDGFYKNVKDNFFSDRAWLRNEFPELSDAIRADAGPRTIVEIGCGPGNTLFPLYSFNENPQLSLHGYDFSKQAVDLVLVRSVDAPSHFICRPHPNLLPRTFQANPSFNPQHLTSAVWDLASPLGLPLTLTAGSVDIAILIFCFSALQPLEWAQAFSNLFTMLKPGGLILFRDYGRNDMAQLRFKKGRLMDDFGGLYVRGDGTRVYFFERDELLAIFGGLKGGETAATMTEVKAEEEQEANGGEAKEEEPKANGSEAMPSEAMALNPNPIMAPEAIAMRTMDKRFELLQLGVDRRLLLNRKKMIKMYRVWLQGRWRKPLENEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MWE9</accession>
    <name>A0A2X0MWE9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">nicotinamidase</fullName>
            <ecNumber evidence="6">3.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Nicotinamide deamidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C004g02952</name>
        <name evidence="9" type="ORF">BQ5605_C004G02952</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; nicotinate biosynthesis; nicotinate from nicotinamide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.19" evidence="6"/>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY69079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MWE9"/>
    <dbReference type="STRING" id="796604.A0A2X0MWE9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008936">
        <property type="term" value="F:nicotinamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019363">
        <property type="term" value="P:pyridine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052347">
        <property type="entry name" value="Isochorismatase_Nicotinamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080:SF2">
        <property type="entry name" value="LD05707P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080">
        <property type="entry name" value="PYRAZINAMIDASE/NICOTINAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="8">
        <location>
            <begin position="4"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY69079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="234" mass="26001" checksum="A73E61C94BA9893C" modified="2018-09-12" version="1">MTRAALLLVDVQYDFLDQPTPGSLAVPGGHEILPHVHHLLDTGDWQLVVASQDLHPSNHISFASRHHREPFTKLVVPRPPSQEAHQQELWPDHCVQGTHGGEIERGVQQRLEAWQGPKLVVQKGTDEDLDAYSAFAIPLTAQDQQLSPLTRVLMEHNIDIVVVVGLATDYCIKASALAAIEEGRKRGWKVLIVQEAVKGIDTEQSQRALEELERKGARVVNMADVELNALAKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MXG1</accession>
    <name>A0A2X0MXG1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C001g00334 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C001g00334</name>
        <name evidence="1" type="ORF">BQ5605_C001G00334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY45755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MXG1"/>
    <dbReference type="STRING" id="796604.A0A2X0MXG1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY45755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="53" mass="5896" checksum="38E2938886225404" modified="2018-09-12" version="1">MQPLGHDNALITLWVSSPDTHSERRFALDLTIADLKVSQLEPEAQHASRRVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MZ14</accession>
    <name>A0A2X0MZ14_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C008g05075 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C008g05075</name>
        <name evidence="2" type="ORF">BQ5605_C008G05075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MZ14"/>
    <dbReference type="STRING" id="796604.A0A2X0MZ14"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY79212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="192" mass="20975" checksum="55D657D8FC8EE18D" modified="2018-09-12" version="1">MSVNPPRFEPQGSYFDQYPDRRTRLNSYAAPIPTHSKTPAESTITTPRRAGLSSRGPVNLASELSQTSFAHRFSSSPQAPPADLALLQRARRGSANGASSFNSDPSASPLSLSSLERPKPPITSPSEASIYRAFTSESSRRRLSIPSCILGEAISTAEQVDQQSGPRFDESYPRERHPDDDFDVNIPSFHAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MZK3</accession>
    <name>A0A2X0MZK3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C008g05245 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C008g05245</name>
        <name evidence="1" type="ORF">BQ5605_C008G05245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MZK3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY79889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="89" mass="9712" checksum="653CE4FF2036F77E" modified="2018-09-12" version="1">MARGLAQHGGWCGLQHVHLSEPERERAIALPLDAPLSISPGLTIFCSLTLSVVYLDSKPSDHTICCLSCLLPVTRQRLPLPTVRRVLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N2S9</accession>
    <name>A0A2X0N2S9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C004g02764 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C004g02764</name>
        <name evidence="3" type="ORF">BQ5605_C004G02764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY67302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N2S9"/>
    <dbReference type="STRING" id="796604.A0A2X0N2S9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048337">
        <property type="entry name" value="FAM50A/XAP5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007005">
        <property type="entry name" value="XAP5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12722:SF0">
        <property type="entry name" value="PROTEIN FAM50A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12722">
        <property type="entry name" value="XAP-5 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04921">
        <property type="entry name" value="XAP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM50A/XAP5 C-terminal" evidence="2">
        <location>
            <begin position="193"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY67302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="333" mass="38540" checksum="185FDDE7796AE297" modified="2018-09-12" version="1">MSAQDEKRKLAILEKKRKDMMDQFAAQKNELVNETNKNRTGSDRFASASDGVDEQLKKSTYGLVQLSDFKVGPLPRLSPRATDRARNAEEEKKKKKKKKEGKVKLSFAFDDGEEDESTSKKGTKAGGDDDEEGTGDEEPPTRSDRPSKKAKLGKNPSIDTSFLPDREREESERKVRDELRREWLTKQETMKAEDIEITYSYWDGSGHRKVVTCKKGDTIAQFLDKCRLQFPELRAVSVDNLMYIKEDLIIPHHYTFYDFIVNRYRGKSGPMFNFDVHEDVRLISDASVEKDESHAGKVVERSWYNRSKHIFPASRWEVFNPEVKRDRYTIHGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N371</accession>
    <name>A0A2X0N371_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C033g11239 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C033g11239</name>
        <name evidence="1" type="ORF">BQ5605_C033G11239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000066">
        <property type="protein sequence ID" value="SGZ02978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N371"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ02978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="287" mass="32002" checksum="3D36C2DB6D53DD05" modified="2018-09-12" version="1">MKSFSSYNVTTSHSRASLVLAYTDSPITVSSELFDIASSAARPEAILMNLFTPGASIKAKLGQAISFATTKDRSSTLQLGYQLDHLLTFDEWQPASFLYAALMAVIFKTTNAGEAFLQHFSRVAMRATSKSWPLWLEYDIVVRANFWAHLARSCSDTASNSITIVDVSHFSPKAMVTAEHRCHRPTGDHLNYTASTGFLSTKFWTLSKVKIEAIVASMEGKRKEIFSAVLRYPHRCRSWRLLPGLIQVFLGECRKVVVVEIVFHPMLRVCSDSRRVLGDVDVRSSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N3Z3</accession>
    <name>A0A2X0N3Z3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C030g10771 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C030g10771</name>
        <name evidence="1" type="ORF">BQ5605_C030G10771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000069">
        <property type="protein sequence ID" value="SGZ08112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N3Z3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ08112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="47" mass="5125" checksum="F1EE7CE257632A0C" modified="2018-09-12" version="1">MCALVNTSTSWSIRPAPLPACLHASAAFRPRQPVQLTLARRRLHAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N452</accession>
    <name>A0A2X0N452_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C005g03236 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C005g03236</name>
        <name evidence="2" type="ORF">BQ5605_C005G03236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY72935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N452"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY72935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="155" mass="17309" checksum="EDB846A4E148AF9A" modified="2018-09-12" version="1">MNMTIAELLAFDVAPADASLHIELSKDEHTQYSTLSSTQCPHKLETSASSCRCSRLISTSAHAEQRLPPFGACPACEMPPAEPLQAAQMPPRKQGAQLQQKGSLRTKQRASQQSKEGLFEAWSHAQHQPKRRAPQATFDRPPRARKRSERVFEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N9A2</accession>
    <name>A0A2X0N9A2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C035g11400 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C035g11400</name>
        <name evidence="2" type="ORF">BQ5605_C035G11400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000064">
        <property type="protein sequence ID" value="SGY97382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N9A2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY97382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="66" mass="7362" checksum="5F05B6F3D274C76E" modified="2018-09-12" version="1">MINKRRRTAGPGVEPGARSTNTFNKAQRRVNVRAQAPPSLPIALRAFERDFLSRAGFVPGARDWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NB13</accession>
    <name>A0A2X0NB13_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C049g12426 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C049g12426</name>
        <name evidence="6" type="ORF">BQ5605_C049G12426</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sel-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000111">
        <property type="protein sequence ID" value="SGZ30667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NB13"/>
    <dbReference type="STRING" id="796604.A0A2X0NB13"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF147">
        <property type="entry name" value="SEL1L ADAPTOR SUBUNIT OF ERAD E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016148566" evidence="5">
        <location>
            <begin position="25"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1003"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="610"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="910"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1031"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="916"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1049"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1082"/>
            <end position="1095"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGZ30667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1102" mass="119416" checksum="C0EF89742CD3FF69" modified="2018-09-12" version="1">MRSILWRSFASVLLLVALARGGVCDRIVFTNHRRHFWDPQADHSNSLTTVVNAQDIEQIPFEAADAATELPISEPDHETYPPITQNLIVSAADKYAIADKYLSQITLHSSAVASTPYAPLLQPSSYTPFLDLLESHLGTTTGRGVRALRKAFGAISGKTKATASNLTSPDWSVRGAIGRLGSAVTSLIRLSASSKSDQGVKKLTNEQGETVVVGTAWKHRLASFQHRSAANSGRPRQSLTVDEVTEGLQEVVKLAREAAEMGHAQAWLLLGDLYLTGHLTLKPNTHLAIQAFTKASQDHGLAEAQYKLGFIYGSNYGAALGGTPGEGQQGDALLYYTFAGLSGHVPASMTVGYRHWVGIGTKQSSMVTFNAGPPGGRLLPSQKIRLSDLEGGSYGPGASASVKSPSGALNIRTQQEWQDLLEFHHFHAERGDVTYQFKLGRLYYQGFGGNGLGGTRGGRGRLQVGMPGLKDNLWEGGRNFRAASQWFLRVTSTVWATDGKEATRNPETKVRDAPQLIYDATKDPKKSTADDHTAMVGGLAAGYLGRMYLRGEGATANYAKAFLWFSRGASRGDRESNNGLGIMYRDGLGVKRDLKKATLYFGAAAQQDLAEAQVNLGKYHFGMGEFVIATTYFEHAIRQDGNRVPDTFQSYYYLAELSARSPDRAEQCLTAVQFYKLVAERGDWGHEVWWEAERAWERGDEHQALLGYWIMAERGYEPAQNNVAWILDRDKQNLRMPFLDVGHADNASDRLALAYWTRSAAQDNVDALVKMGDYYYKGIGNEAGSNVEKAAACYLSAVNTRTSAMAMWNLGWMHEHGHGVNKDYVMAKRYYDMALENSYDAYFPSVLSLLSLYARAAYDAFFVDASEDETKAKALFATDPPTSIVGSSITANRAWSFSQAWRDIQQRWGFEPTPQPAQQGAGGAAAPAAGGDAAAAGGQQVLGAAQVGQQVAPAPAAGTPAHNDLTDAQRALEANEEPADWRRGVRNENQGEDDFFIDGDDDLTGTIAIVGLCVLLGWLLYVRQGQQIRPPPPEGMPQVAVRNGPVPAPAAAAPPQAPAAATPTPTPAPRTATEATPGSSEADARSERDREREGEDLGAPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NBJ8</accession>
    <name>A0A2X0NBJ8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">BQ5605_C044g12136 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C044g12136</name>
        <name evidence="14" type="ORF">BQ5605_C044G12136</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000114">
        <property type="protein sequence ID" value="SGZ31306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF28">
        <property type="entry name" value="TRANSPOSON-ENCODED PROTEIN WITH RIBONUCLEASE H-LIKE AND RETROVIRUS ZINC FINGER-LIKE DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="12">
        <location>
            <begin position="298"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="13">
        <location>
            <begin position="501"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="309"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="758"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="815"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="870"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1451"/>
            <end position="1537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="317"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="762"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="815"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="832"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1512"/>
            <end position="1527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGZ31306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1537" mass="167350" checksum="98A32D1400735BA5" modified="2018-09-12" version="1">MDSSPNTPLPHRDSSPLASSISNQIATLQAQLAALQASQPPAAAASQPTAAAVVANPATVATASKVVFPKHARLDGPKSFTNWLRQLRLALPNQLRAYVLDGVAPATWTADQLAARDDTAREIIVGSIDSADVSATLDAIPSDDLSAPRIFAALKARFAPDDATRTLELFARLWDFRKMPASVDAYDTWLREYMSIAQEIRDAKTSLNDVLATHVLAMVPSCLDSFRLTFTDEQRNQRDLPELTTLTDRIRIQLRSAGLSTSHSAMIATTSPCPACHAPGHRLRDCTSRAQYPPAGPCRRCNKKGHWALDCKPRGGQQRTGDDNQSGMPSSAVHQPNVGYFASGLFARRQLPTDAFVVDSGATTHMVADRSLFTAYRQTAHTKIGGIAGGITAIGMGDVAFVAKTGHPITLRGVLHTLGLHVNLLSVSRLCDTDRVRLAFTSDGIDIAKDGQAIAHGTRKMIAAGLLHGFGAGYSDKDVEEFVCNACLGSKGHRLPFPDSESHSPERLGLVHSDVLSFPTPSLTGKRYLVTFLDDHSRKLWAYAIDHKSDVFPTFQTWLAEVELQTDARLRILRTDNGGEYRSNAFTEFCKSRGIRRQYSIPYTPQQNGRAERVNLSIVEGVLALLADSHLPATFWDEAAAYFVYCKNRCSHSALAKQTPELAWDGQRTTATALHPFGCAAWLTVAPDLRSKLDPKATRVIFTGYDLASKAFRFFDHSANKIVLGRNATFLDDDFPGLPANTPVDADNTEREFTIPADTCVPTSTPAPASTPAPAVKTRTPLVRSAHMDVSSSIDDSTMSAVDVAPGYTGGSLLNSTDTSLSSSPSLPPFSSPATSSAGGPSIDDSDDPLDLLNSNTAVRLNLMDVHRSDDDTLVTPTPAVASAGQPSDDDSPDEIDFLSCHHRAFIATDDDDPALEAIEPVKSITSDPQTWREAMSSDEHDLWAQAAADEFTAMRDDFKVFTIEPRSSVPPGATIVTSKFVWKTKRNARGDITGRKARLVAQGNRQRDGIDFSETFAPVARFSSIRCLLALAAAYGYHVHQADIDKAYLHGELDHDIWMTTPRGFDFPSDKVLRLRRSIYGLKQAGRIWNRHIDTSLRSLGYRATGTDHCIYSRIDDQQQTHYIALYVDDLLIVSPALDEIERVISGLERRYGVKRLGPAEYILGIQIRRLEDGSIALSQERYIMDVLARFHFDTTTQGATVPMTPGLSLTAVPGQGTERIRSWYLQAIGSLLYISLGTRPDIAFAVSYLSRFANNPGRRHWIAVKHVLRYLRATYRDELLYASGSPKITGVVGYSDANWGACVDTSISTMGFVFYLAGSAVSWSSKRQTRVADSTTDAEYLALSHAGKEAIYLTQLLSELHVRPIEAAHIFTDNEAAAAVAHDPVRTSGTRHIRLREHFVRDMVNRGDISLSHVGTANMVADVFTKALGPKIFGTHCYALGLRTRHPRIKSTSHSRGGGCEESTLRSVQDLGARSEPGASRTDLCARSEPGASARDLGARSEPGASGRDLGARSEPGEMARDLGARNEPGLLGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NDY7</accession>
    <name>A0A2X0NDY7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C023g09677 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C023g09677</name>
        <name evidence="2" type="ORF">BQ5605_C023G09677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ23994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NDY7"/>
    <dbReference type="STRING" id="796604.A0A2X0NDY7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="659"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="725"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="836"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="676"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="761"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ23994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="866" mass="96081" checksum="9D5297E7D14D6113" modified="2018-09-12" version="1">MSRSKGSATELLQAIVDDVGDADDLKGVTASLRSAVRDLLRHNASYLPQAAAFFPSSEGAIVLLVARPASTLRFFAALLDHTNTQIRKCLDSNQEPGRRFVEDKVALGQAWDLVMESILLSLKAFLDPTEARAKPLTALDEDLLGKLCYPSLARLLTTDHVISAVQRLILDIFEDSTHLCVENKNRLIRPEALGPKRLAGLFSVAEDHGVTSRALELAFRLRSHLARAPSSAGVSVSSWEAALFPSDVWGPEESQKLRGMFHRIKAREWDEELSTLAATNFKLIFAVTFHANGRAFLCTDVEKPTEDYQDYVSFNRRSISANVLSYLADDDGAQRTIEAPLSGIKSVELFDFSEDHMTCRIILSHSPTLESTPLELPHNEADPSLVLGIHLSDAQRLQQVLMMRKIRYTTRAAEQADVMGRDMANAERRKAAEEPPRTEEPSLHPIKYSASSLRGKSGIPTSSSDRYTPQGNRAGSKRVPRKAREMGAGMKANGQTLGEAADSDTSSDLPRVVRPKTPSTRRDVAPPKQTRHSKPPQPAPKRKSSSRQKRPWDDDTPEERTRNAPPEYRNRSESVLQVSAHEDWDIGGIEPNFDTGPRLERQGTEMEDDRELFQEVTSHGALKVDQPAPRWTAQSREEAPPLEEKELIRDAHWQSPSVKEPVHNIPFKKNLRTPPSLLTSSKASSPTIIPRPDPIAASQLDGRASRSPLAPLAFAFRHHNAARVTSGIREHSRTQTRGRTPAGFGQTPPAKRARVETASAPREHPEAMQRDEQQSEDVLVDLARIVLRKHQLRTNEQTSSLSRSRPAITAAARHAAGEMQEMTVSIASAAHQLSRGSAHRFRDFDSQTRSSRSKALRAVEMIKKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NMS4</accession>
    <name>A0A2X0NMS4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="8">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C010g06091</name>
        <name evidence="10" type="ORF">BQ5605_C010G06091</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="8"/>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NMS4"/>
    <dbReference type="STRING" id="796604.A0A2X0NMS4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1150:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016325">
        <property type="entry name" value="Phstyr_phstse_ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0697">Rotamase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY14178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="406" mass="45611" checksum="C7E021C1CCB4619E" modified="2018-09-12" version="1">MASITTLLPEHMPTTAGPHSQSPPSPSSSPAKRIISRAHLQRFLDSPTHQHVIDYIQRLNEAVVDAVDALLSVLQRIENIVEETPPIDNGKSRFGNPAFRTFYDKVVEQSAELHRSIPNLPTEHVTELSGYFTESWGNRTRVDYGSGMELNFICWLLCLDQLKILTPDDDRAVVIKLFWRYMTVARLLQTEYWLEPAGSHGAQGLDDYHFAVFSRSHKVHSAKHRFLDLIELCLSCLCATVFGSAQLRNHKHLRPKAIHDPEILDEFAKDYMYFSYIRYINSIKTASLRWHSPMLDDISGVKTWAKVNSGMLKMYTAEVLAKLPVAQHFLFGTLLTFPLPPDGEELEGNGEGEEGVHLDAHGHVHVRGEGFGDCCGIAIPSAFAAAEAIRRKEEGSGGKLRRIPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NQF5</accession>
    <name>A0A2X0NQF5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C015g07741 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C015g07741</name>
        <name evidence="1" type="ORF">BQ5605_C015G07741</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NQF5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY17310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="89" mass="9913" checksum="D857B0670E6BAD90" modified="2018-09-12" version="1">MPNLTAKPQVVFIHHQLIIPKGLFTGRKCAEGSPLPVTVHGHPGRFAHTILREADLCALVCTVEARSWRDRSSGKPFVHIAWAWCSFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NS98</accession>
    <name>A0A2X0NS98_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BQ5605_C017g08398 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C017g08398</name>
        <name evidence="11" type="ORF">BQ5605_C017G08398</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY19945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NS98"/>
    <dbReference type="STRING" id="796604.A0A2X0NS98"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000021">
        <property type="entry name" value="40S ribosomal protein S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_uS4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005710">
        <property type="entry name" value="Ribosomal_uS4_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01018">
        <property type="entry name" value="uS4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF5">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="10">
        <location>
            <begin position="134"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="9">
        <location>
            <begin position="273"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="330"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY19945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="361" mass="40109" checksum="E06681665E4B3961" modified="2018-09-12" version="1">MTAGAPSQYKLARRYARSVLTLFHPGGHCTQSSLARSTRCVESRRSIFPPVVSFAVRASFRFCSPALPLAGPSALVGPPDFASCPGAKAAASSRRRTPWTVSRCVTAADLTCSLPSLLLSFTRSCAAPRLRCNRHADLARAHLCTPTPAVPRRPFESARLDAELKLAGEYGLRNKREIWRISYLLSNIRRAARDLLKLDEKDPKRLFEGTSVGSGRMRQDRHHGLLSDTLPLVLCWSTGNALIRRLVRVGVLDETRLRLDYVLALKVEDFLERRLQTQVFKSGLAKSIHHARVLIRQRHIRVGKQIVNVPSFVVRLDSQKHIDFSLTSPYGGGRDGRVKRKRAKAAAAGSGEAEEEEEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NSZ2</accession>
    <name>A0A2X0NSZ2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C011g06439 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C011g06439</name>
        <name evidence="7" type="ORF">BQ5605_C011G06439</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MT-A70-like family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NSZ2"/>
    <dbReference type="STRING" id="796604.A0A2X0NSZ2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036396">
        <property type="term" value="C:RNA N6-methyladenosine methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045123">
        <property type="entry name" value="METTL14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13107">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13107:SF0">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51592">
        <property type="entry name" value="SAM_MTA70L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="6">
        <location>
            <begin position="24"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="401"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="929"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1128"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="434"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="535"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="941"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1155"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1181"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1196"/>
            <end position="1211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY12244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1225" mass="134624" checksum="ECD0309D965DB431" modified="2018-09-12" version="1">MVAPVPPNPQEKGQKGWTIDFEQKTIVVTGGNRGLGKGLTEALAQANANVAIIYNSAKDAEDVAAELSKKWSAKIKAYQCNVGDAARVKEVFSQVESEMSPIVGVVANSGISIVKPIFDLTPDDFKKVFDVNVLGVFNTIQAAGALWIPRKSPGSIVIVSSMSSQIVNSPLTQCFYNSSKGAVSNLGRCIAAEWAEHNIRVNMLSPGFINTDQTAHMPAELREGQAKQVPMGRFSQPFEQAAQALLFLSSHSSYQTGSEAFVDGGFLIWPKKSKLCQVIIGVNSLASSRMPNSAPNVRRADRIGFPSLSLSASPGSQSPTLDCARIRDIRYTELTSSLLERLRSFAFARLHPSSVLLKRATLPLKTSTPYALHTTIFFFNDPLLVTQVDHRLYRLEGNYSPRHNRAKRMGSSPPPPIYSGLPPSNPTSTSSDEPSQPTSTISSTIQANTLHPTPPSPTNLIAPRPTSPSHHQPPQPQPQPQHRSSTASRQGSPASNQNFDQSSSGGSIRASVMQPDKVDEWSLNLGQVKDGGEVGNEDLDLDGEEQSLEKRKRLAWGRGYLHEHDSIRNDYSHHYVSTGQRPQNYIRGAKVEERFSEYPKLSRLLDLKHTLLSSPSNSLPPTFLNLPSSQIPLRKTLFTTLDPTTNKFDVILLTPPPSTTFDELKALDLGKWSHSPGFVWLWVGDGRSGAGEGVGLERGRDLLGLWGYRRCEDIVWLKTNTTQPDSQDNSSPSLFTPSIEHCLMGIRGTVRRSTDPWFVHCNVDTDVMVWEGDELGTYLSIDIPHATKTSSAELRFVTSDPLLKPPELQSLIENFCQGTRRLHLYGSPRSLRRGWLTVGIPITSTSSITSDKEVSKVFSEKSFVRPIERESQEWTPTAFDSSIYASSIQSTSASPTLLTSLSQLNLQDAVHDSPLPPYLPYHIELDTLRPKSPPARAGQASSGGLGRGRGAGLGVTKSLVAKGEGLKQRGGGMEMRGAVFLPPSSAAPTLTTMIRSDYGSIHPDAMLDPIEVPTTMEDGRMGWISPRFAIAQGQGQGRGQGASFELPLHRHYQYQLPYPVFQQQQQQQQQQQQSHYATNVSHVVRPPISSFAPLHPHFLPSASSIAYFTPHDQAHNYLTPHYQHPLLRDSSYPTLDPHQHQHQQQQHLVPPTGFSQSQSQSQYYAELHYQPQQQLQQQQAHHPHHQLHPRHPSVPAPSSFPSSRSVASAASGDGDWIYPIGGPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NT93</accession>
    <name>A0A2X0NT93_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C011g06539 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C011g06539</name>
        <name evidence="1" type="ORF">BQ5605_C011G06539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NT93"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY12549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="118" mass="13449" checksum="622901793E5A92F8" modified="2018-09-12" version="1">MDNSKNTDSSKGRITQKNRFRELRLTICGRSSTAPFAGVTVVLAGDKFSQDAFLLFSSHRLHRSSTLASWNADFWGEMDNSKNTDSCTTAFRSGPTQFFTEPCLYRINIDELFYFQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NTB1</accession>
    <name>A0A2X0NTB1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C010g06065 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C010g06065</name>
        <name evidence="2" type="ORF">BQ5605_C010G06065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NTB1"/>
    <dbReference type="STRING" id="796604.A0A2X0NTB1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018554">
        <property type="entry name" value="FRQ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09421">
        <property type="entry name" value="FRQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="744"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="808"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="894"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1097"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1192"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="438"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="559"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="744"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="808"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="830"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="844"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="894"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1246"/>
            <end position="1257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY14108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1257" mass="135269" checksum="8E0B2B1E26366911" modified="2018-09-12" version="1">MSSNNDLSGHSTTTTTTGESSRGGHRADTEASSSVDPGASTSTTPSGAEPTAPWPAAADDRCTAGSGALGLPSSSSSSSSTWPLHPSHPKVDSQLDLIREDEQHTMHPAGSSSQHHHHHHPLTQDGHSHGHAPSHASHRYPLSRQESSASDFDGPKVKYGPTTSTSTGLTAGFTHAPWTHLNKPLPDTLGRAHVIPRSNKGKGRAIDGVGGVDDKDSLENASLRPSVSASLPPDTSDDETDESDENDDDDEEDDVEEGASKVLKKEGHRDRGWKSTNLLKGLVQSRRDPLIRIRRVGALGISVSSNDSDGDENMEEAVTSEEKGISDDREDAGITAGTSSLDSASELEARKAKGTRRTPQAVGARNEEFRTIVDDLALENQVLKAKLRRYEAARVPATLKRDRLFEIRYFEGLSEEKREDLETFLTRYVQGISQLHDTSTPTSAVASAATTPTTAEHRPQVLLHSSHPIASTVLPSLPPPKIPDRKFHRSRKSASSERDVLAGPSDFGFEPTSTTGTGAGIKIDSWSDSDRKKRKEKKHKKTRKHRRADDIEGPSKAVEAATTSGDTGETTPTKEDEPTAMWATRENTQRPSVTIDDKSMSTAQAVVNSIEKLFRSSFEARCKGVKGTQSNEEYLSELLEQDFLSNGWVYLKLVCTMAMTYRFSVTMPFIESAIRTLSTRLEVSSSGAKVRWKGTDLFKPQTGGSIKEDRPTPMVVTGPFSDAMVPSYADRRRALDQRRLSWHAPSSTGLDSSISDMTGDRERSWNCGSGPVASTAATSLYPDSVVHKLEGADAATDARSQITRHTPTTAAVQSLDLSPGSQIHPLGSESKVPSVKAAAASSVGRRTQNSPGSHATKSSLPPPIKVSTHTPYLPFFSRCDHVLVRSSGAALSRGAASTAGGNSSAQASGSEPKRVVATDEDEVGITGTMLFYANAKFCSDLSKEPLSEVWPSDLNAPLPLGYRPREEVSVKRSPSPDGATILGKAVRVVLPIDDDEAMDVDGKGSLHFDDGVAMQPSQNTWANEPLSFGQLQGLKTSGMSDVSPADAFTIVVTLRFDDLPEPTIEKRTRPDAAITGETSKKRPRFERYQIVDTRMIPHPPTSLVRPRLRKGLSHVSSSSSSNGGATSDETDADLPLRGIPLLVRQSSPADGASLIESTFSGPISQVHMPSPDYLASLNVPIYTWSPHASSSRFHWSQSSRGPSTGTNHRPRSHRSTTNAPLLRLGDSVLPIQGTDGGDMMTTSSEEDIRAIDLDESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NVW2</accession>
    <name>A0A2X0NVW2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C015g07715 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C015g07715</name>
        <name evidence="3" type="ORF">BQ5605_C015G07715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0NVW2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1205"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="649"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1784"/>
            <end position="1809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="650"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY17225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2028" mass="226034" checksum="A835B6A197663E99" modified="2018-09-12" version="1">MGNEDSKPLNYSTLRNTLGILAAIQAVPGNRADRFVQAIFATPDFPSTVATALKFSALNATRNIINPFANALEVSLSHKSTGRASATDKGELVACVRTLLSPNTPICFDTGVPLSGDLEAFMPRITGLQHSSTFRTGVLHHRITVGFVSAEARDAALASAPMLVWNSANARFAKAHPFHRNMLEMRINVGVVRPPSKEQIVAAFQSIVQQLSTKGHSCQLVQVLRVIHVDTAKAYAHTVGDFSAFIHFDDASLFQHPTTTLKEILPSRMDLPTRGLDVTAVRHDYEKEAPCARCHFAGHVERCPLMQAANRKEAEDLARHAVMRGAGMVGGGEQTGVGRAATTTTNNIRPTANNNNTSEVVAPSRALGTDQLESRNRFAGLEVEGGQEDDIEEEVAGKEGEEKEQVEEGDEDTGAKADDEDSDSDGNAGAGIDKAGGDNKDDDKDEQDDSSEGSERRGDDVMKDGAEEEDEEMETEVEEEVEQEQGVQDDSIMIIDDGQTTITTVSRESTPRSPSWPPLSPETLAKSLREGAEWDRANAEAAARVQAENEAIINAQLDAQEPLVRHQFAEWGQEDGQLRFINIRGTGSRSNKKMKRSQTVADLSDPSDDPVDVKRVLNRVKGRAGKEVAGQGKRVTRSMSAAAAMQVEGAKAKAEKGKGVEEEKRWSDHEPEDDILPEFPLFEDNITAKSTWNVRRCMGIPEKRRDIYTYLSTFKASAILLQEHFIKPELWQCIKDEYEGKAFISKHCLTLIPADSPLIDAEILRTHSALDGRILVTSFRLRGDIRILEINNLYAPVDTKQRLTFFDKLHFHRTQSTHLRLLGGDLNDCPLPAIDRRNQGRHGHHWPILIGKLDSPYTDCIRFKHPLTPSFTRPNIVRKRPKSFSRLDYFLLQRTHQKRLVQASTIYDHPKDLSDHRPVSIVLVLSDERGDAAQPNNSLPTTSNQLHRINAATFKTAAFQGMLEGWLEGASGEEPVGELEVVLGNCEKEGRELARREHRERVERMAVLVGRVQDLEALPVMGDEETAEWTRTTEELRRAVNERARQLRIRAHVPEIATEERLSRPVHAKLAARSSDSKITALRLPNGELTHDIDVALDHTQAHFQRLYNLEPRDRDHVERLRDDFLAPIRAARTCDDPSSDPLFLRRLSEAHIELLQQPITEDEVVAAIATTHPGRSPGPSGVPYELYHTAPRAWAKALSRAFNAMTERGSLSPKQGQGLVRLLFKHHKIGADRAELSSYRPITLRECDYKLFTKVYVARLNHVLPDLLPPQQHGFVKGRRSADASFHLRLLIEELGARGTEFPDAALLSLDQSSAYDLVEHEWIFAIFDALGAPATFQRVLRMLYSGDSTTARYIINGFLTPPVRLTCGLGQGDPASSSVWDVVFQPFLDALHRRGIALNLSLPTIHPYPQSRAITSLAFADDVVVAVAGSESLTLLDDLALDWRLATNGRLNTDKTVVLPIGCRWEAGDRPLVVKAEGESLEWIGLSFDPTGNTELANVNLVARLEAVLDSARDRGLTHHTRAFYVNRYAIPKILHILSADIPPLEVVKELDRILVDFVRGGKRRACYGKDVVFTPRFKGGLGVMRMQDVVDSVAARVWDVLLGGSDAIWQGLARAAIVRAHPAPDFDLATDAWPCDYTPIRTDLHPRWQAVLKVPSTHNAQVKPRTLTLANLLALPIKLHTLHYLPGAPAVSRSPYDADYAAFANYAKVADLFRRELYPGGGFHLWTPPTDVVVSNSEYDQRGRPQREHIVAWYRHAINRLRFTPIAQPVAAVRINGPPRVRPRSEVRPTTPLESILPHPIDPPQRLPRPALPDQSTQYNLLSMDRPYTIRRVRRVLNAKAFTDTIGFRDSLQPDDLKGFWKGVNSKALTAREREVWFKLVRNFTPTRSLQFHQKHDDSPACLVCGAPKDDREHYFFDCVDSGNVWIAARSVLCDALGLDTIDNTHYTAVQRMFGLPKLKASLRDQEGAGRTIEIFTGLVLEMISSGRWGMQKWGTRMEGVVRRRIILEERLKLRAGGAWGRRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NW07</accession>
    <name>A0A2X0NW07_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C002g01314 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C002g01314</name>
        <name evidence="1" type="ORF">BQ5605_C002G01314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY32067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NW07"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY32067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="77" mass="8511" checksum="8FC8D540C39D5F95" modified="2018-09-12" version="1">MAQTQEAKSMTAIAEQLLNTCLIRVQADSIIIQAHVISIPVPELIEFEKCSNGLHLHRPGGRILVKTFAQNNFDLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NWD2</accession>
    <name>A0A2X0NWD2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C015g07905</name>
        <name evidence="9" type="ORF">BQ5605_C015G07905</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NWD2"/>
    <dbReference type="STRING" id="796604.A0A2X0NWD2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000026">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051370">
        <property type="entry name" value="PPIase_Pin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023058">
        <property type="entry name" value="PPIase_PpiC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657:SF4">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00639">
        <property type="entry name" value="Rotamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01096">
        <property type="entry name" value="PPIC_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="WW" evidence="7">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="8">
        <location>
            <begin position="115"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="31"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="105"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY17824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="229" mass="24214" checksum="E45A88487166FDD1" modified="2018-09-12" version="1">MSDTRQWEIRFSATRKRPYFYCPTTSESVWEAPPALTPEKISTLPGAHHLAYEPPPPAGAASPSTNASASASASASAAPTSATAVHAPTAAAAAAAPAAAAASKQPAPVDPSAAPTKVRASHLLIKSEKSRRPSSWRQLHITRTVGQAREILQTHQQNLQAAEDLPKQFARVAKAESDCSSAREGGDLGFFGRQQMQKPFEEAAFALKVGEMSPIIQTDSGLHLILRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NXZ8</accession>
    <name>A0A2X0NXZ8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C003g02086</name>
        <name evidence="4" type="ORF">BQ5605_C003G02086</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY38845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NXZ8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="129"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="257"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY38845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="303" mass="33525" checksum="72D1A6CB538C3341" modified="2018-09-12" version="1">MSPVQTEAQASPSFSLLLFTPCPSHLIPSPPRARDIRSGRRGSSATNTGSRNACRMQHSYAFELWSRELRLTIPWQILNVLARDHRVGSNAFPSPSTARFGGVTVVLAGDPKQCLPVILKRSPTQIVDFVDAPGGTRKTFLEKAVLARIRSEGTYALAVASSSIVALLLPKGRTAHSRFKVPIIIFDDFTCNVPKQGQFAELSRMCDLIVRDEAPMQHRRCFQLVDTMLQDVRSSTARFGGLTVVLAGDPRLDFMDNSKNTDSCTTSRRSEGQQQHCQWERPERERSEDLGHIKCGDSGKGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NYR6</accession>
    <name>A0A2X0NYR6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C003g02396 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C003g02396</name>
        <name evidence="8" type="ORF">BQ5605_C003G02396</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY40564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NYR6"/>
    <dbReference type="STRING" id="796604.A0A2X0NYR6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013946">
        <property type="entry name" value="NCA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234:SF1">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08637">
        <property type="entry name" value="NCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="619"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY40564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="767" mass="84364" checksum="CDC3193B56E618FB" modified="2018-09-12" version="1">MTYASDLAASLGSSLSSLTPLLLEAADESELDSSSSPTPPVASQPTAVDGIASRAQVIHDRASSLRSVLSKLHPSHPASSFELASLLDQAFPSSSSSPSLSTSSNDRPSLQAQAQSSNQLQSIEYVTLAHMTISAYGLVLKQLMQQASDLAQEDEWWAGRETDAWDQGWYLLQSELSRAEQLAKHSPTDALPPPTATPSRLVSLSMTLVTRLRDLTTTALHSSRPAPSYLSWSTYRDALPPSLLVTAIFPHLATSTGVASPTDVLGPFENDDSTLAVTSSGGVSFSHATRLAKKTTRSLFFLTLSPLALTRQEIFHRRKTIRQTRQSLAISIGELTLAPQPLIDGDHQEQQKANDDDGKNRSERTLPAVLTMTDQEPATLNALKDACWTTLVHLTSAIATSPNSSSNLPSPPEASKPSSAQECARVLHTLLTRTMVAQAKTLETQLEQVSRPPFLTRAWPYLLAVPLVSYGIGRTIYNSRHDLLHYARDAVDTVQRFVMDWVLEPVKGIFETVRGEGGMSLTGKETLKSDLDSLERMVIDFGRDEYKLSEAQLVDLRDKVRAGDLTPVLKAFEHDLKSPLRSAISGSLIRTLLIQVQKVKVDVALAMDGIEKMLRSQQLTFGFVGVAPSILVLFAFGNWIKGFTRRDGSSKKRRKEWGKRCWLSTRQLDLLLAPPRDIEAPTKISKGDRIGEKEKLTQGLVLLCLANLRNYAKRGIFPSRDTQLRQAFLEDVRAIEDEGARAKPEKRAKMVERMWRWGTALGWQGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NZC5</accession>
    <name>A0A2X0NZC5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C019g08842 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C019g08842</name>
        <name evidence="1" type="ORF">BQ5605_C019G08842</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY22684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NZC5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY22684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="298" mass="33321" checksum="ECB00715E88143A5" modified="2018-09-12" version="1">MATTSNKAPPEPERLRLDLAPAVEIAILRDGQCNPPAAVASIKPARSSSPSTAFNPVMPIVEALREGSWKRADQAVLRNEIMPRVLLSSTTDLIEEVFDIPRTHFELMWHRAGLSGVAQDAQGSHLVRFRKDLRFCKARPRTCRLRAGLRVLRDMWCHAHHKRPHEFRLSAAVAQRPYRIGVHDELNDYDEYTDVKDLPSLTTPFLTCARDAPSSPSGATIWNRVMAMVAVDRSPYDAGDEVHAPELVRLVFDVIEHVLAQPSWLYAPGLAINENVAYLVVLDLETHHGSCVSTFILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NZN1</accession>
    <name>A0A2X0NZN1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C019g08982 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C019g08982</name>
        <name evidence="2" type="ORF">BQ5605_C019G08982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY23790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NZN1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY23790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="162" mass="18154" checksum="78530DFBB0353F49" modified="2018-09-12" version="1">MTKTNRRTKTATMRMKTARKGTKRMVMANVRVFGSFSEAPFFSRSQFFAHYLPNATSTSQSRIATNVLSWTIPGCDGVRCQTWKASAAHHDDVRPRLTGNQGCTGADKACNRPDLIARMFEAKSGNKRHAGCFGNECKMNGFCFFATVRLSCYFLNFILTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P0W3</accession>
    <name>A0A2X0P0W3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C084g12997 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C084g12997</name>
        <name evidence="25" type="ORF">BQ5605_C084G12997</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000039">
        <property type="protein sequence ID" value="SGY28623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="515"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="262"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="791"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGY28623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1365" mass="151736" checksum="16F8C28E13AB0ACF" modified="2018-09-12" version="1">MRLRYEPNELPAAQESGEIKIAKLGKDNYELWSIRVEAYLESKGYASVLEHGHVRPSDVSLAEWRTMHGLDASVTDTQVVVNLQKKDRSARALIIQCIDDANLKMVKSKTLSAKDIWDKLRQHHEGNAKPFKIRTLLMELSNAKYDEDENMGEFLKSMIDKADQLDDLGQKFGDEAMIAYILQALPPSYEMLKQAIRLGENRSVDHVINRLTDEYTERKLSGKFDKLLKNAGALAVQSTQASRDPNCVCRGCKGKGHFAMDPECPKYDAKKNHGRARNRNKKKKQDSKESADSNELAEFVLTVKSLDESHSLQDNVANRVSQLNQGEIWILDTGASQHYVGDASLLSNRQSGNLKVQTASGQVVHCDTYGMVRFKLKSGASLSLANVYHLPGAPVNLISTRALFKSGAKCGWEDGKDVMTITYQGVILAKTLSGTGYALDFTRIVEDQAHVATRATVGAPLMEWHRRYGHVPVSSIMELVKSGAVEGLVLTDEKVHDCEPCISSKSRASKFSELATQVTDVLQRVFMDIGFVAEDQVDFQGRKAYLAIVDQYSTAKWTFPLKTKSAEEVTRVWIAFRQGVEKMTGRKIKRVRTDNGTEFTNKLIGADFQSQGILHETSAPYTPQQNGTVERFNGSLMAIVRAVLAASKLSWKYWSYALAYATFVANRILHAKLEGKTAYEVFYGKKPKVSHFRPFGSTVYAQVPKSKRSKLESTSVKGIFIGYNSEYNYRVLVDPDSDHKVIVTRDISVLEHKSEQVGVPEVTTLPVGPDEEKGPVDNDEIVVDKLQDQVDGEQMPPARQNRPRWEYGDPAVKGRNPGRYEEIDANNKIPHRTRSQRRDAEQQVMYGSAMSVSLPPVPSNYEEAMASPEADKWIAAIKAELDAMARHQVLIDSDLPSGARALGSKWVFTRKENAQGEVTRYKARLVAQGFAQRPGIDYNETFAPVARPSTILSLVGTAAAQGLFLEQFDFDSAFLNGTMTEMVYMNRYEKFIYITLYVDDGMVASNDQEFLDSEIEAFNKVYKLKRLGPVKLFLGLEFERTSDYIFVHQSKYIRDLVAMYGGGSVSKHPVKVPMEPRSDVEHSTDPFDDVALYQSAVGALQYAAHRARPDIVTSVRAAASKVSAPTQADWIAVKRIIRYLQGTVDWGLKFNHGGSTVFELYSDASWGDDMSTGKSIGAFVSILAGAAISWQSKQQSMVATSTTEAEILAASAAAKEAMWLRRLATDLELEQPKATLIWEDNQAVIAIALNPAHHGRTKHYNVHHFYIRERVTAGDIRIKYCKTGAMTADILTKPLARNLFELHREGMGMVSLGALTRTYGLSSGAGARVLCGGPAEAAGCLHEIASFWPSCFSLFSTTHSISHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P110</accession>
    <name>A0A2X0P110_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C001g00901 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C001g00901</name>
        <name evidence="1" type="ORF">BQ5605_C001G00901</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY50590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P110"/>
    <dbReference type="STRING" id="796604.A0A2X0P110"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY50590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="66" mass="7539" checksum="C0243F2B5B5E2AD6" modified="2018-09-12" version="1">MVRSFALVKIYGMAREGRSLVSGQYPRVNARLVSLYWIAFLSAPTAQQPALEIQPREDIRRCRGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P1G4</accession>
    <name>A0A2X0P1G4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">BQ5605_C006g03927 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BQ5605_C006g03927</name>
        <name evidence="16" type="ORF">BQ5605_C006G03927</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY54902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P1G4"/>
    <dbReference type="STRING" id="796604.A0A2X0P1G4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="15">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SGY54902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="191" mass="21933" checksum="992195705DF17694" modified="2018-09-12" version="1">MRRKRSGALQLVTDRGGEFVNRQLDDWLASRGIVHELSAPYKHGQMGLQERLWHTIFDKVCTALAQSGLPLFLWEEAAHAAVYALNLTATSALDDSTPDLVFHASDDPVANHRRLRGSRLRVWGYCALVPLLPEQRGHKLAPWSHHCFFVGYLQTSKAWRFYDPARRKVFELSQATFYEREFGRTHNAKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P463</accession>
    <name>A0A2X0P463_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C004g02721 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C004g02721</name>
        <name evidence="1" type="ORF">BQ5605_C004G02721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY66915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P463"/>
    <dbReference type="STRING" id="796604.A0A2X0P463"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY66915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="215" mass="23788" checksum="8ED5E16CBE7F3DCF" modified="2018-09-12" version="1">MSHGKERSSQTVPTALLPLPERPVPWHNLGSMTLQCPICSALHWEFEKSPTPGGATPFKICCADGKFRVPAELLALLTGDGPDYKGHGIISGSGPPSFYLSGMAFHRIGTLAPAPANDPVFAQILFLAPTERIEARRRFNGPPEEVRRLDSAYQQIHKNIMDSDASHMYQLCLLAPRNRDPRTYNLPTQDEVAVILPGRQSLFLKIGNRSHLRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P5N6</accession>
    <name>A0A2X0P5N6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable methionine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="2">6.1.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C005g03273</name>
        <name evidence="13" type="ORF">BQ5605_C005G03273</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="2"/>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY73202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P5N6"/>
    <dbReference type="STRING" id="796604.A0A2X0P5N6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.220.10:FF:000001">
        <property type="entry name" value="methionine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="METHIONYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="11">
        <location>
            <begin position="67"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl-tRNA synthetase anticodon-binding" evidence="12">
        <location>
            <begin position="456"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGY73202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="613" mass="68969" checksum="800DC1AE5C7C2667" modified="2018-09-12" version="1">MFRLPTRHAPLPIELITLTRSCAGAWTWYACAAPRSRLALGPPLRLGLGAKRSFSAASASQDKKQFFVTTPIYYVNADPHIGHLHSTLLADVLARYNTLRHSTHGNPCISLLCTGTDEHGLKVQRVAEAQRIAPLELCDRVSQTFRDLANLAGIQPHTFIRTTEPRHRQAVQHLWRELKNKGYIYKSSYAGWYAVSDEAYYSENQVTDTVDPKTGEQIKISIETGSRVEWMQEDNYKFRLSAFRKPLLEWLASEPNRTSIGHTSFHSLKDLQDLSISRPSSRLTWGIPVPDDADHTIYVWIDALVNYMTVTGYPWTPAGANMNLAWPPDRMIVGKDIIRFHALYLPAVLLALDLPLPKHLLAHGHWTMDKFKMSKSRGNVASPFTAIEKWGSDAMRCYLMKVGGNSAVDADYSDEAIEVFYKKSLKGQMGNLISRIGNRKMVQRVEEGGRKSWDVPEGVEDVDEEVRKALIELRDTFESHMNKFELHRAINALFDALTLANKNIQQLEPWAETSSSETVHRALFYSSETLRIIAILIRPVMPQKSKQLLDMLGVAEEKRGWEDAVLGQGGERTLDVLGRDQLFPSLAVKKPKGGDGRDIVSPLSTDLSNAVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P6L1</accession>
    <name>A0A2X0P6L1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C001g00626 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C001g00626</name>
        <name evidence="6" type="ORF">BQ5605_C001G00626</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY48200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P6L1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF153">
        <property type="entry name" value="RECQ-LIKE DNA HELICASE BLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY48200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="413" mass="45954" checksum="F16A16F9DEBA5275" modified="2018-09-12" version="1">MSVQTPSPVRGPPRRHPSIEFRASPLRSASRASPTTPAPNHSTNPTTVLGHWRPRLTHEDRRDSSELRKKIKVILGESLDEDSTPRPVQIEAIAALFELDQFGSRDRYDAVFVTAPTGSGKSVIFEAMYLMYGRRAVTIVAANLNRKGKKAVVVSEETWRDGSCTGMKCTCVDFSSCLLRVKSPEMHINNADWAKLISNESFRERVKLLVYDEAIKIAEWGLAGGADRAGSMSHTIEGSMAFRPVYGQVAERRLTLGCQRLFLTAGAPPHKIDRILKVSSLARSRTFFAKADLSRPNLRNIVVEMKPRTKGAMGSIRDLLDKRPDPSTFPQSILYFNSRIEMANALLALHEQFGLPITVDSPLARKFNAVRGELDTSEDIKDFEKGSFPFFSTTSALTVRGERVGRWPSQFGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P6X3</accession>
    <name>A0A2X0P6X3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="13">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">BQ5605_C001g00805</name>
        <name evidence="18" type="ORF">BQ5605_C001G00805</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20 21">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="13"/>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY49697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P6X3"/>
    <dbReference type="STRING" id="796604.A0A2X0P6X3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17960">
        <property type="entry name" value="DEADc_DDX55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056330">
        <property type="entry name" value="CTT_SPB4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23681">
        <property type="entry name" value="CTT_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="17"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="48"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="292"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="551"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="17"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="605"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="615"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="649"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="SGY49697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="684" mass="75936" checksum="7122D13E2EA734BE" modified="2018-09-12" version="1">MSTIDRLASAPSFAGSWSSLQPSLTPWIADVLRDMGFSNMTPVQAATIPLFMQHKDTVVEAVTGSGKTLAFVIPVLEKIIRREKPLGKREIGAIIISPTRELATQIHSVFSSFISAQPSTSSTPLPPPLLLIGGIPLASDVKSFYESGADIIVGTPGRLEEFLLGNSSVSSGPQHGKRKTSSGNSLGVGSTKELEVLVMDEADRLLDLGFTPTLNRLLSHLPKQRRTGLFSATMSDGLSQLVRVGLRNPVKVVVKVEAKKQYDDKGAEVKGADRKTPASLSNVYVVCTPSSKFVTLSRILSSETTATSTARKFIIYFSTCACVDYFYKLLSALPEAFPYSIHSLHGQMSPTRRSATFEAFSSLPSETTGILLCTDVAARGLDLPDVDVVVQFDPPQDPKVFSHRAGRTARAGREGKAIVLITQGREEEYIEFLRVRKVPLTRLNYSEPTSKKDLTDEIALVEQFRRIVLTDRDLHERGMKAFVSFVKSYSKHEASFIFRIKDLDLVRIARMYGLLQLPKMPEIKGKEVEWEKVQVDWDAYGYLDKVREKQRRSQLAAQNEARKRTKRPIDDQDAENDARPSEDADGEPSTKKKKPGKPIATKAWSNKDDAEARAKLRREKKLRKLKALHAKQEAGRPTNDEGDLEEGEGDWKEELARKKMAQREAKKKDRGTTSNGMAQVEFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P6Y6</accession>
    <name>A0A2X0P6Y6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C005g03613 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C005g03613</name>
        <name evidence="8" type="ORF">BQ5605_C005G03613</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Lipase family. Class 3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P6Y6"/>
    <dbReference type="STRING" id="796604.A0A2X0P6Y6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051218">
        <property type="entry name" value="Sec_MonoDiacylglyc_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856:SF24">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="7">
        <location>
            <begin position="272"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="580"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="582"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY77350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="599" mass="64619" checksum="11EC5A4125C719C0" modified="2018-09-12" version="1">MSQSGHNEQTLAEGRDAATGGQPQRLAVHVEELVSVLSCRGDSFIQHSRSSLFYAFFHYVAGNTLAFLTTLVVAPASILFDPLSTIATLISYPGIYTILFVAIFGLYLASSMGGSALINYISRKYADGYSAVNWASPALINSAQSANTIRSARATLGGLKTTFPDAVAPGALPSSPPKTNRIFDLDVAKACLSMCALVYERDDKLVEKAVAKAARGDVQGAEVLLLDSETTIREQAAKWDLNYEGISDLSSTSGPFASAFYTQSGEEKPFIVLVFKGTTPSNYAEFLTNATITRINATSWFGDGTVHEGFATSLFPMFDERTDGFGQILFQLKHIAETLSPDPESSPVPLFVTGHSLGSALASLLYTRLLRVPCDLGKGIVLRDCYLYGTPRLGDAQFAAKFEESTITPINRPNIMWRVKNNRDIVTRIPAGFAHPQAAGMVGTSTSVLNYAHIGVEIYLRPHKAPYYEADTTQLHHATRVVIVKDGSQHPPMSSRLVAYNSSYTNALRWALCFLLPDFAWDHLPASYAQVSRTEARLTETCQILGFLITFTGTLSQHLDQITATGVGGSARGKRQEALTVGAAARPNAAGPLASSSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P9B6</accession>
    <name>A0A2X0P9B6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C007g04493</name>
        <name evidence="6" type="ORF">BQ5605_C007G04493</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY60843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P9B6"/>
    <dbReference type="STRING" id="796604.A0A2X0P9B6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11380">
        <property type="entry name" value="Ribosomal_S8e_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.168.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.168.20">
        <property type="entry name" value="Ribosomal protein S8e, subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001047">
        <property type="entry name" value="Ribosomal_eS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018283">
        <property type="entry name" value="Ribosomal_eS8_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042563">
        <property type="entry name" value="Ribosomal_protein_eS8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00307">
        <property type="entry name" value="eS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10394">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01193">
        <property type="entry name" value="RIBOSOMAL_S8E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY60843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="213" mass="23916" checksum="E01545A598DDA420" modified="2018-09-12" version="1">MGITRDSRHKRSHTGAQRAQYRKKRKFELGRQPAMTKLGAKRIHTVRTRGGNTKHRALRLESGNFAWASEHATRKTRIIGVVYNASNNELVRTNTIVKSAIVQIDAAPFRQWYEAHYAQPVTKKGLKKDASGAAVVEGEAKTQSSHVKRDLAERQKQAKIDPLLESQFQAGRLYASISSRPGQSGRADGYILEGKELEFYLRRLRAGKAKHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PDP6</accession>
    <name>A0A2X0PDP6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="26">Folic acid synthesis protein FOL1</fullName>
            <ecNumber evidence="11">2.5.1.15</ecNumber>
            <ecNumber evidence="13">2.7.6.3</ecNumber>
            <ecNumber evidence="12">4.1.2.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="27">Folic acid synthesis protein fol1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="33" type="primary">BQ5605_C008g05049</name>
        <name evidence="33" type="ORF">BQ5605_C008G05049</name>
    </gene>
    <organism evidence="33 34">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="33 34" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="24">Catalyzes three sequential steps of tetrahydrofolate biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19949"/>
            <dbReference type="ChEBI" id="CHEBI:17836"/>
            <dbReference type="ChEBI" id="CHEBI:17839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="EC" id="2.5.1.15"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11412"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde</text>
            <dbReference type="Rhea" id="RHEA:10540"/>
            <dbReference type="ChEBI" id="CHEBI:17001"/>
            <dbReference type="ChEBI" id="CHEBI:17071"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="EC" id="4.1.2.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DeSI family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">In the C-terminal section; belongs to the DHPS family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the DHNA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="25">In the central section; belongs to the HPPK family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.15" evidence="11"/>
    <dbReference type="EC" id="2.7.6.3" evidence="13"/>
    <dbReference type="EC" id="4.1.2.25" evidence="12"/>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0PDP6"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.20:FF:000006">
        <property type="entry name" value="Dihydropteroate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="entry name" value="7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="entry name" value="Dihydropteroate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006157">
        <property type="entry name" value="FolB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="FOLATE SYNTHESIS PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941:SF1">
        <property type="entry name" value="FOLIC ACID SYNTHESIS PROTEIN FOL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02152">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00905">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="Dihydropteroate synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00794">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="22" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-0418">Kinase</keyword>
    <keyword evidence="21" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0645">Protease</keyword>
    <keyword evidence="34" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="29">
        <location>
            <begin position="548"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="domain" description="PPPDE" evidence="32">
        <location>
            <begin position="929"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="30">
        <location>
            <begin position="1078"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="31">
        <location>
            <begin position="1225"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="1075"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="28">
        <location>
            <begin position="1084"/>
            <end position="1110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00009640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00009951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00012458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00013043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00013253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00058009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00061548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00067568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00068111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="EMBL" id="SGY79121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1530" mass="166467" checksum="683CE1E09988C845" modified="2018-09-12" version="1">MMQHPSASLPSRDLIQITSLALRTSSLEQDLWQRPSKAQPLFLSLWIHTDVQDEASTDSLLGSSLNYGTVTKAIEKAVAELAPLPPSPSSSDELNLDLDSFGGHPLEAIAELLAKVVLFRSNAPCVRLELIRPRALLTAESLGVDIFRTRADYTAPADTDPSVSIEALTLDPSSPNLAHDKLFVRGLRRFIIIGINACERLEEQEVIVDLDFLANQEVFMVAHRLKNGARREWRAWRQVVKKVEEPLTIEHITTSLAQLIVTPPTCSTTSLPLSWNVPRTSVRVSKPSALMFAKYPSVQVTRDRKDFFDANGALRASSARGLTTDAWSAGTSATAESSSSQSTAATEIVEEGGEPHRVVLGVGTNMGQRVHNISEALKELGVIGSQNGHKTRVVGTSFLYESEAMYVEEQAKFLNAAVEIETTLEPLPLLHALKSVEDRLGRQKTIRNGPRIIDLDVLFYDDLVFDSRQTTTTVVTPEDRWLQIPHASIAEREFVLRPLVDLNPHFRHPKMGQTTSGLLYALSIGPSTLKRVMPLSASLAPTLPLRRTWVMSIINTTPDSFSDGGDNVDLEASVATALGHLAAGADILDIGGMSTRPGAADVTPEEEEARVVPLIKALRERGVTNPLSIDTFRPSVAKAAVIAGADIINDVMGGASEGMLEVMAAADVPVVLMHSRGTPATMSKMTDYEAGDVVAGVRRELAQRIQEALDAGVKRWNIIVDPGIGFAKTGADNLALLRRLPEVLGRQEVGDSAEYDDHDSTLLRQFPSLVGLSRKRFIGTLTGKDVAKDRVLGTAAGVTASIAGGAEIVRVHDVEAMVDVAKHAREAPVPFREWPIASICFDVTRRPVPWALGGLVRFASPSPLVPSAPSLRPFPLWLLGLQITSSDWTELLSKELCIHQHRQLLDPTSKSSTPHVIREQTTGIMVAAEPVSLYVYDLSNGMAKQWGRMLTGRDVEGIWHTSLVLHGMEVFYGQGIDIVSPPGTTHHGRPVKQLSMGSTQIDRDTFLEYIQGMREVYSADRYHLLDFNCNTFTNDVLGFLNGNQIPEDIRNLPSEIMSTPFGRNMRPMIDQMFRGGNARPDASNAVQSLLPPTTGSNSSTATPSQQSMGSNLQICTSPASMQTALSENPAVAVMFTSNSCPPCNAVKPYFEELARTHGAGPKRIVFVLVEMGLGGGAQVASDPAFGGPIRATPTFVFFARGEKLGQCQGADRQELKTQVQLLEMEVYPAHAHTKLSLPAFTKLSKSLAPVTYPSFPPLPVLAKKLDASLNNHQDKIDSTTRDVLTKRVIAYLAALPAPPVAPTTPLPADAWIPATEKALEALAPQEWFPLLDTYRIALARDISRLSASTAFTSLIPRLLERTCTDLESSEKALILTLVRLVSNMLPSPTLVNLLLERSSFDTVTRIIVRALLDPDQSVRSAGSGLAWSIISRVYDRRVGLASIDADEEWQVEMASALFEALSKEEESVEVVHRLAATLGLLMFQSSHADPVKELLGVLGLEEVVNGKAKLLEGNAEVAQLFKELDVLCQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PI65</accession>
    <name>A0A2X0PI65_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="26">BQ5605_C032g11027 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">BQ5605_C032g11027</name>
        <name evidence="26" type="ORF">BQ5605_C032G11027</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000067">
        <property type="protein sequence ID" value="SGZ03881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0229">DNA integration</keyword>
    <keyword evidence="20" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="18" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="21" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="17" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="18" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="19" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="25">
        <location>
            <begin position="544"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="25">
        <location>
            <begin position="1752"/>
            <end position="1918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="843"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="899"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1482"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="843"/>
            <end position="875"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="SGZ03881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2224" mass="245375" checksum="28420E9EC9A449A8" modified="2018-09-12" version="1">MDSSPASPLAPRDPSSPESSIGEQIATLQAQLAALQASQPAAAAAATPAVTAVPGNAATASKVVFPKHARLDGPKSFTNWLRQLRLALPNQVRGYVLDGVMPPTWTADQLAARDDAAREIIVGSIDSADVSATLDAIPSDDLSAPRIFAALKARFAPDDATRTLELFARLWDFRKMPASVEAYDTWLREYMSIAQEIRDAKTLLNDVLATHVLAMVPSCLDSFRLTFTDEQRNRRDLPELTTLTDRIRIQLRSAGLSTSHSAMLATSSPCPACRAPGHRLRDCTSRAKHPPTGPCRQCHKKGHWALDCKNRGEQARRSDDTQDDTSSSAALQPNVGYFASCLFARRQLPTDAFVVDSGATTHMVADRSLFTTYRQTAHTKIGGIAGGITAIGMGDVAFVAQTGHPITLRGVLHTPGLHVNLLSVARLCNTDRVRLAFTSDGIDIAKDGQAIAHGTRVNDGLYLLDADHTKCQHLAFLSRSESPVPLLTLHRCLGHLAPSSIQKMIAAGLLDGFGAGYSDKDVEEFVCNACLGSKGHRLPFPDSESHSPERLGLVHSDVLSFPTPSLTGKRYLVTFLDDHSRKLWAYAIDHKSDVFPIFQTWLAEVELATNARLRILRTDNGGEYRSNAFTEFCKSKGIRRQYSIPYTPQQNGRAERVNLSIVEGVLALLADTRLPATFWDEAAAYFVYCKNRCSHSALAKQTPEFVWNGQRTTATALHPFGCTAWLTVAPDLRSKLDPKAARVIFTGYDLASKAFRFFDHSINKIVLGRNATFLDNDFPGLPVTTPVDADDTDRQFVVPADTPAPAVKTRTPLVRSAHMDVSSSLDDSAMSAVDVAPGYTGGSLLNSTDTRSSSSPSLSPFSSPATSSARDPSLNDSDDPLDLLSSNTAVRLNLMDVHRSDDDTPETQAPAVDPVGQPSDDDSPDEIDFLSRHHRAFIATDDDDPTLDAIEPVKSITSDPQTWREAMSSDKHNIWAEAAAAEFTAMRDDFKVFTIEPRSSVPPGATIVTSKFVWKTKRNASGEVTGRKARLVAQGNRQRNGIDFSETFAPVARFSSIRCLLALAAANGYHVHQADIDKAYLHGELDHDIWMTTPRGFDFPSDKVLRLRRSIYGLKQAGRIWNRHIDTSLRNLGYKATGTDHCIYSRIDDQQRPHYIALYVDDLLIVSPHLDEIERVICGLEQRYGVKRLGPAEYILGIQIRRLDDGSIALSQERYIMDVLARFHFDTTTRGTTVPMTPGLSLTAIPGQGTERIRSWYLQAIGSLLYISLGTRPDIAFAVSYLSRFANNPGRRHWIAVKHVLRYLRATYRDELLYAHGPAKVTGVVGYSDANWGACVDTSISTMGYVFYLAGAAVSWSSKRQTRVADSTTDAEYLALSHAGKEAIYLTQLLSELHVSPIAAAHIFTDNEAAAAVAHDPVRTSGTRHIRLREHFVRDMVNRGDISLSHVGTADMVADVFTKALGPKIFGTHCFALGLRMRHPRLKSTSRSRGGGSGRPGPGLRRTERGWDLGARSEPGPLAQPRGSLAVDLARAALLLVDRIVDRIYISLGTRPDIAFAVSYLARFANNPGHRHWIAVKHILRYLRATYRDELVYTRGQARITGVVGYSDANWGACVDTSISTMGYVFYIAGSAVSWSSKRQSRVADSTTDAEYLALSHAGKEGIYLSQLLEELHVQPVAPAHIFTDNEAAAAVARDPVRVSGTRHIRLREHFVRDMVNRGDISLSHVGTSDMVADIFTKALGPKVFLTHCYALGLRTRHPRLGGDCLISLTGKQYLVTFLDDYSRKLWAYAIGSSPLWASEVFGVFKTWLAKVELETGATLKVLRTDNGGEYRSKTFTDFCKARGTRRQYSIPRTPQQNGRAERVNRSIVEGVLALLADAHLPKTFWEEAAAYFVYCKNLCQHSALDKETPNSVWQGERANALALHPFGCTAWLTVALELRSKLDPKAVRVLFTGYDLASKAFRFYDTTTKKVTLGRNATFLDTEFPGLRGDSAEQDDDTHFASAPFADPQTTVKSWTPLPQVRLDPPDVHRPDFGRYREPALAEESPDELDLIGRHSRDESPDEIDFPTRHHRTFIATDDDTSDAEAIQPVKSITSDPQTWREAMSSDKSEVWARAADDKFNSMRDDFKVFTIEDRSTVPTGATIVTSKFVWKTKRNALGKITGHKARLVAQGNQQRDGIDFNETFAPVAQFSSRWRPPTACTDKVLRLRRSIYGLKQAGRIWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LPH6</accession>
    <name>A0A2X0LPH6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C011g06566 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C011g06566</name>
        <name evidence="2" type="ORF">BQ5605_C011G06566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LPH6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY12636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="224" mass="24039" checksum="F46B44F683F2AC7C" modified="2018-09-12" version="1">MNMTIAELLAFDVAPADASLHIEFFSRTIVYQAQLSKFWSKLTPTSSCSTQGRPMDSSDSTRGEAGVGVSNTEEGRSTTHSSVLKGLVQSMGPSRCEDTAGTTRSLNEIQKNAYIEDGRIQRQAVWSASTTLSSFGSLDGAVTATTPLEIGSLICFGLKCGMHSLSCEQTVSGEEALSIGIGTRIQSDTKPLQPRHARLVGSTLKCRRTGASPHQENMLFHTPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LTA1</accession>
    <name>A0A2X0LTA1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C010g05888 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C010g05888</name>
        <name evidence="2" type="ORF">BQ5605_C010G05888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LTA1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY13542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="79" mass="8162" checksum="6457EC688BE1D617" modified="2018-09-12" version="1">MPDGRLEPEAEATEDASSYVGAGFGVSVANRHQRASGTVGGNLVTHDSRGGMRSVVATDEGGPEGGVSFLIVMTVWKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LTQ4</accession>
    <name>A0A2X0LTQ4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C011g06510 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C011g06510</name>
        <name evidence="4" type="ORF">BQ5605_C011G06510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0LTQ4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635:SF196">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="444"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="925"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="384"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY12445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1598" mass="175765" checksum="FA95B036AE1D8F82" modified="2018-09-12" version="1">MRQTNSLLAWTGIHMSACKDEGAATVSYPSESRAHSLESQQGNSYWMDNNNNTNNASHAAIPPLRPDPPDPPGQAPATTTKSYSAAVGARSAAKHGNATANASTAVAAHPLMHNIENCVIINTPPSTSVEQVLLALDKYYPGLTGAMPCVIKGQRGLRFPKAADLDTLVANGLTDVDVLPPASLSIARDGVTERIPLRITGGMRHCVFCRSAAHVRKDCPVAPACKSCASTSHATQHCPARHGSSPQGPPTSRAPQASTVTTAAPAAVSKSISPTSAHDRTTKKRRVEQDLAAQTEDLSNRAQPDSLSKNARPEFSFNFPCKTATPPAPQPASNQGIAYSLVEKSSKSPSSETTSPSPSPPPATPKSIITRSKLIAALSKPATREAPPTAPALEASEPSPEPSSPTPLPSAAPKARPDDADTDDEADEEAEDQEAPPKDSINEDRKRASLFSNLRSHNAEVFLLSETGRPSPERVAQWTQECQDLKLSALFTPFNNTAILWKSDSVVITFDPESPPNTLRASFSFPDRVTDATFCVGDSKVRVVSIYAPSSDKPDKKRFLSHLSTALRQVVRDEPSPPALLVGGDWNCVESQPLDSENQNGTNYGGQEMRDLATANNLFDAYRLHHPKGRATTNHSAPGTCRRLDRIYVSPDWVDLFHDHKIWAVVLKSTHSMVVARFQVPGAIDIGPGKFKLGLHVIKGDATCEYLTSIVRTLYNKALLQTPNDPPAAWTSTKHRLLPELQALARTFARFRRGGSEQERADHSRYGAALRSRLDPSLAGPSSIFIRLRKVRASDLIPSLTVNDVVHSDPDSMLGAASDYFERVYEDRPIDDAALKAIIDGLASTRLSPADSLKLEEAYPLEEMTKAQAACKSNSSPGPDGLPVEFYRATWPATGPILRDVINSIPTKACQPGPLPRNTAHIHLIHKRGERDQLSNKRPILLINADKRIISQAHNQRLAPLLESLIGPTQRGFVPNRWIGTNIAEVQCLMDPGLPGSTPVSGMLAVMDFEKAYDRLSHPYLDAVLCAVGLGPKARQWYRATYTNQSASIFLNGWLSATFDILLGVRQGDPLAPSLFVLAIEGFACQIRLRVKGIDIAGLQNVRELLFADDACCALHNLSDLDHLNRAIELYERASASKLSNVKSFLYPLGAFRDRSIAPDLGTWRLSDSQFRYLGIQVGVEIAEDAGWEDVKASTIARIRSIPMYDLPYAAKCSIINIYCYTKILYYSRFLPAPKSVVKEIEEAAMLAIHGRASDGTQRRPKVSRSRLCTPLDHGGFGLIDLPRRLAIDHAKWVFQLRAPDGCFTCHLFDIRIRLQAPNEPTPFTLSRPAPNQHRCPWIWIWWAYFCHPPPKWDHAVRKTTKLLPARWVRYFEAWALVTTLNPPELSKSQNLEQWATHVLYFPAGHGIQLSVNPTLFRGPDGEVMTPSSFVNASKRHQVFIFPPIFPKGHQKVFDLPEQRWNAWWKALRKVRRVHSDAEDTGHLLSLGSLHPGSQVASPTSPHPNNRSTSCVMCLSEAPECLVHLAVSCPFARRLWSALSPTPHPVFVDFVCPVVSRSERRLVELRVLFFHSIWKLCRRRRFSSDLLEPITGTEFEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LUY0</accession>
    <name>A0A2X0LUY0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C017g08440 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C017g08440</name>
        <name evidence="7" type="ORF">BQ5605_C017G08440</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY20026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LUY0"/>
    <dbReference type="STRING" id="796604.A0A2X0LUY0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF13">
        <property type="entry name" value="MFS GENERAL SUBSTRATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY20026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="319" mass="33813" checksum="B2E71EF2E08B75CD" modified="2018-09-12" version="1">MFGAPAPFEMTFGLLILSTLLSVFFLPYIPPDAQSPKVNGEGVLAPLKIFWPRHVQVEGTSRSVRYWGMTWLAIGSFLGVFATAFVPLALQLTATNMFGFGPKKNGYLLSLTAVSRAAFLTFAFPRAIARGRIWLSGPKVEPTSPSAPTRPPQAPTQAKDLEPLSLNPDELTESAPVPEPTDQVHGSRFDLFFLRMSMLVDACLTACVTSTTLGWHVYLAALILPLASGTAPAAKGVIMELVEPSQQSLALQAIALVESLAMVSTVSVLGIAFAMLSEVGKGPWIFVVNGSIALVAAGTLMLVRFPPRGVVGTAVGGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LV29</accession>
    <name>A0A2X0LV29_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C013g07091 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C013g07091</name>
        <name evidence="3" type="ORF">BQ5605_C013G07091</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY14761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LV29"/>
    <dbReference type="STRING" id="796604.A0A2X0LV29"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000001">
        <property type="entry name" value="Tropomyosin alpha-1 chain isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19269">
        <property type="entry name" value="TROPOMYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00261">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY14761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="186" mass="21504" checksum="50388FA45653667B" modified="2018-09-12" version="1">MDKIKEKLASLRAEADAAYARAEAAEAKNKQLDHELMTKDQEIVSLTHKIQNLEADLDKLETKLGEHKSVSEDSEQHKSSVESLSRKVALLEGELDNAEKQLKETTDKLSAFSQIATHRWMQMTDRKFSLTSRLRQVDVKAEHFERQVARVEQERDHMEKKAEEALEKYNQAKRELDEVVQQMESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LW28</accession>
    <name>A0A2X0LW28_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C019g08870 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C019g08870</name>
        <name evidence="1" type="ORF">BQ5605_C019G08870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY22902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LW28"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY22902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="124" mass="13939" checksum="74AB1FEBA4A0FED2" modified="2018-09-12" version="1">MKPLSLVNRKFSALAGCALHLGLVSPRVVHAHHDLGDSLFFYNDLLAQYGQYVLKAYYFDPSSAFLTQPQMEIAEFKKELREGYDVPYDPTFHSLLSVVKLEKTLDAIEPARLCKGRPDHTAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LWJ5</accession>
    <name>A0A2X0LWJ5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C012g06782 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C012g06782</name>
        <name evidence="1" type="ORF">BQ5605_C012G06782</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LWJ5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY16161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="88" mass="10162" checksum="A8E77111088AD8E4" modified="2018-09-12" version="1">MTYCEITPLISHNKRLFGLPKLKAKLSKQEGAGRTIEIFTRMVLEMISSGRWRMQKRGTRMESVERRRVVLEERMKLRAGGARGGRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LWM3</accession>
    <name>A0A2X0LWM3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C012g06964 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C012g06964</name>
        <name evidence="3" type="ORF">BQ5605_C012G06964</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LWM3"/>
    <dbReference type="STRING" id="796604.A0A2X0LWM3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037473">
        <property type="entry name" value="Lcp-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37539:SF1">
        <property type="entry name" value="ER-BOUND OXYGENASE MPAB_MPAB'_RUBBER OXYGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37539">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="495"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic" evidence="2">
        <location>
            <begin position="168"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY16722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="526" mass="59815" checksum="3E563F3B6844F011" modified="2018-09-12" version="1">MSITSETIFFGDAQRITTKASQVKVIHTPHDLTTCEPGQLLQRWDFISRYNDDCLPFSFTDPLRHRSDPLTDDVVDLLDLKPGQDGLKAVEGYFQREGKAVSAEDEKIPEPIRKFWKEVHRKPPNSISGFVEGGAEDNPRQLVEAMKNHDRSGKGRVPSLAEGQAVFWRYSAPIFVALMHFTLAGGFSAPHLSATMKETNYLTSKLRDASYRRLLETSLMVLDCMSDMTIDQGIGWKSAIRVRLLHAQVRRRIRLGQGRLNAYSVEEHGIPINQYDLAIVLGGFMIAPLWSLRRVGLYLTSFESAAYVRAWTHVGFYLGIDESLLERMYGRTFATAETSFAWLAFPAFPSEVPEDGYSTPAHRILSAVSGRPPAARTVGHHRELSRMLLGTRLADQLALPRGTTKDCFTSRYETSLSTAFILFGRYWPRKEWEEERQAWFREVMYLITLYHLGEKRTTFAWREEGRHEHKLGEGEGEEAGRRMGPAVGREIRRRWMWLLGEMVGGTVLVLGTVLVGGWKVWSRNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LWT0</accession>
    <name>A0A2X0LWT0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C012g06872 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C012g06872</name>
        <name evidence="6" type="ORF">BQ5605_C012G06872</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LWT0"/>
    <dbReference type="STRING" id="796604.A0A2X0LWT0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050891">
        <property type="entry name" value="TatD-type_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060:SF15">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060">
        <property type="entry name" value="TATD FAMILY DEOXYRIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01090">
        <property type="entry name" value="TATD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY16441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="380" mass="41950" checksum="EAE933AC9830386F" modified="2018-09-12" version="1">MSTAPETTAAAVTASSQNVSPPPPVLVGQSRQASASSETANMKLRPLSNFTDIGSNLGDPVFQGSYHGKQHHPSDFLAILSRARLAGVKAQLLTGDCVKGAQEVIELTKKYDGLYATVGCHPCRAYEFDQHKEGPEAYLETLSRLIESNRDEVKAVGECGLDYDRLNLCPRDVQLRHFPPQLTLARKFDLPLFLHSRAAHEDFIRILKEDGQGLRGVVHSHSGSLQEALDCIELGYFIGINGYASSHILDARRSIMTTWAETSSFLPSRCSLKTEENVECVRALPLDKLMVESDCPWCEIRPSHASHPYLSSLPPKLKTLYIPQQTKKERWVEGKGVKGRSEPSSTGQVAWVVAQLKGISLEEVARITTENTRRLFGDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LYE2</accession>
    <name>A0A2X0LYE2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">guanosine-diphosphatase</fullName>
            <ecNumber evidence="5">3.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C014g07522</name>
        <name evidence="9" type="ORF">BQ5605_C014G07522</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">After transfer of sugars to endogenous macromolecular acceptors, the enzyme converts nucleoside diphosphates to nucleoside monophosphates which in turn exit the Golgi lumen in a coupled antiporter reaction, allowing entry of additional nucleotide sugar from the cytosol.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.42" evidence="5"/>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY18969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LYE2"/>
    <dbReference type="STRING" id="796604.A0A2X0LYE2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009134">
        <property type="term" value="P:nucleoside diphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24040">
        <property type="entry name" value="ASKHA_NBD_GDA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF83">
        <property type="entry name" value="GUANOSINE-DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="163"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="371"/>
            <end position="375"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY18969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="643" mass="69351" checksum="1757D15564A728AA" modified="2018-09-12" version="1">MVSYPPHSTSTTTPSTPTISITSPGQSTAASLASTSRSQTRHDASPIRTRTKGDYQATGTEEDHEGDGNEHDHEHDHAGAGQEDDFDLEMNLARGALNGRHNNGRLGHPGASSSPGSHPFRALTPKRIAIIAGSLLLLIFWFGKGTGTGSFPGVDEAAHNHASTDLITTPNGDDDNKVDDIEPNLPPESPQKQPSKGSSRCTPPPGKKATSYALMIDAGSTGSRMHVYTFSLCDPSPHAVPKLEHEGFYTTKPGLSSYAGRPQDAAESLRGLMDHAVAEVPPSERSCTPVAVKATAGLRLLGERESNEILREVERWMRKEFPFSVVDDGVVIMDGRDEGVYAWITINSLLGLIGPKTVNPAGSAAIMDLGGASTQIVFEPTFGPASKQKLAPGDHVYDLDFAGQPHTLYQHSHLGYGLMQARRAVHNLVAFSYVWLSAPTGRAIEWDDLTEKTRIPNPCMFKGETKVVKLDPPGRKEVHVTMVGTGAGFEACRRVVDVMIAKDAACVEPPCAFAGVYQPALREVFAAGKVWALSYFYDRIAPLGLASPFAISDLRKLTSDVCSGRESPTWSRFKGNPEAKSELDGRPEYCLDLTFMYSLLSLGYELEDERQVWIGKKVGEIELGWALGAALAMAQGSLKCRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LYP0</accession>
    <name>A0A2X0LYP0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">BQ5605_C002g01426 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BQ5605_C002g01426</name>
        <name evidence="16" type="ORF">BQ5605_C002G01426</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY32957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LYP0"/>
    <dbReference type="STRING" id="796604.A0A2X0LYP0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005745">
        <property type="term" value="C:m-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000019">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000003">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050928">
        <property type="entry name" value="ATP-dep_Zn_Metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655:SF2">
        <property type="entry name" value="AFG3 LIKE MATRIX AAA PEPTIDASE SUBUNIT 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AAA ATPase AAA+ lid" evidence="15">
        <location>
            <begin position="151"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M41" evidence="14">
        <location>
            <begin position="204"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="35"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="82"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="395"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="83"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="419"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SGY32957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="447" mass="48325" checksum="3452997D2C69A6E1" modified="2018-09-12" version="1">MRPGRFDRHIAVSNPDVSGRRQIFKVHLKNLVLETPAEGKEAQDTSPLEEGHIEHSSGNSPSPILTALGSNIQWSHSTSIDLASAAPTPSGTPSRSPKKSSTSATKKASPTSSAASNPNAKPTKEGSNFQSMYTFKDDADDNTAPSRLARKLAALTPGFSGADIANVCNEAALVAARLGADFVTEQHFEMAIERVIAGMERKSRVLSPEEKETVAYHEAGHAVCGWFLEYADPLLKVSIVPRGVGALGYAQYLPKERYLYTTGQLMDRMCMTLGGRVSEEIFFGRITTGAQDDLQKITRMAFEVCANYGMNLAVGPLSYRQDNDSFQKPFSEKTAQLLDDEVRKMVNDAHKRTTDLLTEKREQVEQVAQLLLRKEVLSRDDMINLLGRRPFEKADPYDEAMGGVPPSGGALADKPSGDGPLGGGIEGGHGVPVPEPKGIEAGSEKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LYV9</accession>
    <name>A0A2X0LYV9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C017g08496 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C017g08496</name>
        <name evidence="4" type="ORF">BQ5605_C017G08496</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY20154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LYV9"/>
    <dbReference type="STRING" id="796604.A0A2X0LYV9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016287">
        <property type="term" value="F:glycerone-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052744">
        <property type="entry name" value="GPAT/DAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605:SF0">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="509"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="3">
        <location>
            <begin position="39"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY20154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="669" mass="74811" checksum="2FF830567AE63A92" modified="2018-09-12" version="1">MPFGVAHPLLRYIAQFATTSFYSRIEVINGDQVPEHGPVIVLSNHHNSAVDDPRWCSVPNAPRRRAGPASWSRWGSPRSPRPEYTEHGSSTFQDRMGIPYIVPSIHQATSVLSIKFPHGRMLHYWAKSTLFTNKIAGSILRSAGNLSVDRKTRVSSFTLEAPPRFVSHSLILIARQDNSLLFASTFDVLKQGECVALFPEGTSATLPGLLPQLKDGASWAALEYHKNVREKGRLLSNGIDSVDEDPQELTICLAGISYTDKSKYRSAVLMEFGPSFNVGPFLDEFEVDPKAAAKRMTKHIAEALTKLTVNAPDWDSLNAATMARKMLWVDERSIPLRHLVQIGQTLVDLFATRTPSPELRQLTNLLLAYHKALKDTSFTHHSLSGVPLPDKLDPNNKHDLPTRMRVLGHLLLSTGKAMLRLPFFAAPLIVHMPIYLMGKYSLRFSDLQEDHAQNKVGCRIGEMSRRCDELTVSRFRRNCPQIAVCLILSMATYVTLFFLAWAFLFIAPFGFILAAIFVWLFAVYHNSLVDDNYLGAKKVVASWRVLVGIWSAHAKHETLHQIHSLQRRFPSTSISNGFSSETTSTTQQRTSTEVMSMPLLHEDNVSDESNPIRRVLSLRVEASAALGEFLLGDEEGKRVARRLEEWGAKVRKVRKEVSAGQGAGSVRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZU7</accession>
    <name>A0A2X0LZU7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01816 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01816</name>
        <name evidence="2" type="ORF">BQ5605_C002G01816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY35917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LZU7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="370"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY35917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="396" mass="45987" checksum="15CE07C79C404572" modified="2018-09-12" version="1">MAPRATEGERAWLDIDSHLIDLIRDESGQWRVRCELCNKHYKLPGGYRSLDGPTVAPEHAHEAKRNLKKNHSYRRQLQAKLDMLEAPGKADRARHDEWAAERARRLVMEPKDIMTQDPIPEDVENFDYEVREEIDYVMWPDEWAGYKGNGRLPRSLLTVLIHWRNVLFDAYDNQKRKRGGGSARVLKEYRTRIQDFDDILARIFTVPVDIAAEHEELRLFSEILSPLYQECQRPLPEDDVRTDEDQEGSDRLLRWIRKAYRPFLGKRVPDDYRDQLESEHRTWQAALRPFATTVLVHVPEPPKPPTDADLEPERKKIWDSWIVECAHMWLALSSKQRDAYCWMRKKEEDAISEHSSATGQHSDHGSAAGSEAESNLSTLSELTSLSELERGLDTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M0V4</accession>
    <name>A0A2X0M0V4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g02168 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C003g02168</name>
        <name evidence="1" type="ORF">BQ5605_C003G02168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M0V4"/>
    <dbReference type="STRING" id="796604.A0A2X0M0V4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY39205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="303" mass="34179" checksum="7BB528E90A48BFC9" modified="2018-09-12" version="1">MLFASSQHRAYLKMTRNRRRYDSTTRQDRRRQADLFRLHKLSLCQYLSWYFSPSTQHDIVHNHRPKLFNSNWTQLKHLIIQLAREDGRDARGRINNWISNQMKRTKPAFVSSHDMAPEVLASDQIDARLDATVESNSFISGRIRNLLSHCGDPPPVEESNCDKLSSDFTDVDMEDAQEDSSGSDAERGCFKEQHVSFLCRSIMGQIAFACNRRNNAMQHRNGLMALASDRKGNSLNSIDGDRRGAPLTGGGVCTGMVDPEGGSDVVDWRCGPKVGPVRRSWLIHVGAKNRPSGSVREPAPSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M1J6</accession>
    <name>A0A2X0M1J6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C018g08777 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C018g08777</name>
        <name evidence="1" type="ORF">BQ5605_C018G08777</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY26764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M1J6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY26764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="119" mass="13120" checksum="94A46800AA67A476" modified="2018-09-12" version="1">MQLRARQYTVFAKIPPFGSIDRNVTSAMPLKIGSLVCFGLKQGIIPVSCDASNIGEEQLSIGLVRYMDAKATSNHCDRAETDSLTLLSNVVLQEFRVMSKGRYSTHMIDGTTRFFGLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M1N3</accession>
    <name>A0A2X0M1N3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">triacylglycerol lipase</fullName>
            <ecNumber evidence="2">3.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C003g02478</name>
        <name evidence="6" type="ORF">BQ5605_C003G02478</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="2"/>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY41167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M1N3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF1">
        <property type="entry name" value="LIPASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY41167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="187" mass="19728" checksum="4A40A6C525DE9197" modified="2018-09-12" version="1">MFGHTGSSRNGSSRLLTGAWIAFVAASIFASLSAVAAAPVPVVGKAAIATAQSQCAIADFGSFAGVSLLTTNFTSLGPNLLKDPIVAKYMNMGNLATNPKETPTRPQLYMFHTSTDETVPYGPALKTAQTWCDEGARIEFTTRNGGTTHAQTQSLYSPQAIAWLDSTLKDSHVVVRQCAFLTKGLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M2X2</accession>
    <name>A0A2X0M2X2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C002g01531 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C002g01531</name>
        <name evidence="4" type="ORF">BQ5605_C002G01531</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY33710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0M2X2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051412">
        <property type="entry name" value="Formin_Homology_Diaphanous_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691">
        <property type="entry name" value="PROTEIN DIAPHANOUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691:SF6">
        <property type="entry name" value="PROTEIN DIAPHANOUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="2">
        <location>
            <begin position="353"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="3">
        <location>
            <begin position="1138"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="922"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="961"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1043"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1581"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="278"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="926"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="964"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1048"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1077"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1581"/>
            <end position="1600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY33710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1784" mass="193982" checksum="A0504CACACCE4DDB" modified="2018-09-12" version="1">MELLHILLPGKPISTSHSLITFISPSCSLGDLVRQVLNEREAGTVRRSIVDDDDEATEESSDDSLWGLQGVDLQHSTANSHLPVLGEHGLLLSTMLLQDLFPNLGVEVSSSSSPPIAASTRAQEPRLRLVHRLHFVDVETPLSKRRIFINKHTTMRDAFDMLLEDDPSLVGLDLLEKASDGTLSRSSLDVPVQSWRMTYPASRLVMTPQASKESQYKRPDSLWRPASIFGELWASATATSSHARDPGGSVQSQVGEAEDPEPREGGSTIKRESKPTFSSTPDETSSQSESSSQSLLARTRLSTMFAEWISPTEVVATPKSERPKTFVSEPIPATQLMSLRGVPRQSFSDDDLELPMADEDVDREIEKLMGDLGIKDAQRATMQALPIDQKCYLISQHHSTSTPLRSSKTGPDRPAPSQAGAFESFKRLSLASVVGWSETTATPIEARPVGRSMFDASGAAAPTGGTSWTSWWTVASNPTGVSTTSVSGMKDTPAFYVDQLKSTKVSERSLVKHLIALRVRLSTAKVSWAEEFLQECRGLEALQRLLEKIVKKRKTRSAQFHNRRRGGVLTRSSEWPRSSEAATDEEETVQTECIKCLRVLMNTDIGFSSVFASPDSIKLLVCSLHISPSSYKLRSHIVDILAALCVLSCENGHTIVLEAFDHAAADVAHRFECLVEGVKLMGEEETGGDGPAGIWEWRTSAMSLVNALVNSPDLLEVRIKLRAEFARLGLNEILVALRYMGPPDYLLTQLNVWAEVRDEDTEHGQTLRRQDGLKLSASTEGALSVELLQLMQGRADLWPQVVEATRRVVDEASAGIYQPQQGSEALQGQITTLLRQGEIQEAEVKKLRDALAEKEEEIAARSCVRPVPSTDASIQTSIDESLSVPYSTDVTLELSRKIEETARLRMELDEAKRRLKLLTAFGRRAPAPPPPTDPATPPVPPDAPLLEPSNQTLFDVLTSTPVEIIPPPPPPPPAPPSPPVQSVRTCAASIPLIARLQAARGAEALLGFPMPAVQISDSPKEISQDKTRLDRKLQATLASRQPLMSELGPPPPPPPPPPPPPLGQPGKIALSGSAGPSPSPAKGPTPPEAPSPPPLPPPIITSKPQGLSAAPFAPPIGPSWIQAGGGNALPSSAEAKPRTAPDSPPKKTRPFFWTKVAPHQLASSNVWSHIDTAVTVPELPDLIEVFQLAPNARPGGATANAAVTEGKKKAGVTTLLGMTRAQNVSIMLARIRISHQEIREAVFSMDDGKLSIETLKQIAHFAPTADEVRSCALNDQYSLLMGLVLQTTLLRSYGGDKKLLSPADRYFYEVSLRKPYCALTPSKLIIFQLSQMITIPRIPSRLKAMIYRRQLEMEMEELKPELSILRCATTELREGMKLKRLLAMVLQFGNTLNANTSRGNAAGFRIGALLQVCHELQLKDIKSSSSTTPTLLHYLVRAINLSDPDLMTWAEDEAPHVEAASRATRAVSFVTVMASVKSLIDGMAQVQEELVLAHENTAPVQGDQFIPLMETFVSHASDAIIALEQTSHKLQGDLVSLLEYYGEDSKTFKPEGLFETFNAFSHSLLHGENELKDIDARTKPANRGEHLKMPEVEQGKEKHPPSASPPKAGRRSIGRGGFDAAVRDLRSGIIPRRQGSSATIRPASKIFLDGAARVAAATAGRLHFVIVFDHASARPALKALSPDNFQRRSSDRNTDPTTEWVTNFGAQGELALAGHVLDMSSEVTVVISAHEADPLIAANTRLGVIGGVRVQGDRTVGQQGFGLLADDRKRTESSPVRKEGLLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M6C6</accession>
    <name>A0A2X0M6C6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g04219 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g04219</name>
        <name evidence="2" type="ORF">BQ5605_C006G04219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY57086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M6C6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY57086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="379" mass="41949" checksum="D13C5928E29D0FAB" modified="2018-09-12" version="1">MNMTIAELLAFDVAPADASLHIELSKDEHTQYSTLSSTRCPPGHKLETSASSCRCSRYQFLAQLANLIAHQAAHKCSHLKLFYSREADGIEQPNSRRGRRSRGLVQSMGPYRCEDMAGTTRSFRWTGGDQMDRALTTHEDPEESNGALAQRYPHFGALDGGAVTTTTTSKIGSLICFGLKCGMHSLSCDQTVYGEEALSIGIGTLFNQDTLASLVLLSNVVVQELRLLKKTCYSTHLIDGTMPFRMIDGRQVIESLGPSTTTYRSTTDLTSCYPDERLISTSAHAEQRFAALRSVQCTACEMPPAEPLQAAQMPSRKQGAQLQQKGSLKTKQRASQQSKEGLFEAWSHAQHQPKRRAPQATSDRPPRARKRSERVFEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M8S4</accession>
    <name>A0A2X0M8S4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C001g00957 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C001g00957</name>
        <name evidence="9" type="ORF">BQ5605_C001G00957</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY51076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M8S4"/>
    <dbReference type="STRING" id="796604.A0A2X0M8S4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035075">
        <property type="entry name" value="PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035248">
        <property type="entry name" value="PRMT5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035247">
        <property type="entry name" value="PRMT5_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738:SF0">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05185">
        <property type="entry name" value="PRMT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17286">
        <property type="entry name" value="PRMT5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17285">
        <property type="entry name" value="PRMT5_TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRMT5 TIM barrel" evidence="7">
        <location>
            <begin position="86"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 arginine-N-methyltransferase" evidence="6">
        <location>
            <begin position="384"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 oligomerisation" evidence="8">
        <location>
            <begin position="548"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="740"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="782"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="745"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY51076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="855" mass="94267" checksum="4123362E28055058" modified="2018-09-12" version="1">MPMTDRLVVALHLPQELLPLSGSHAVVTGNNPSKAYSTSTTPRGYGPPMPVDGTPLTRLVSATLYDHSPISSNDHPNSHGSSNRTEYDLVALPLTNRNWQERWESMCVSMTSQSQFDLQTQTGNKLQSQQAQSVAEEAESWRGGGAFHRHQVNVTRSEETASLIAFASDWLELDSPDEGLRFDSELALRQEVTYASYLSLTTIIVAPPRAEFADFLPDYARAINGALASSWHINISIQLPLSLHPPPHLGGRSSTPVGSWASAQDDCQTWEWWNTIRSMCGYSPRLSICLDLSNALPATQFLGRWAAEPVKHIFLPCSTFIPNAKAYPVLTKSLQAFLKRCFRFNPTVILSGTQKGLHAMGGPLAYVQYVRHLHRKAAPLDPVEQYAQGYMDHLQLPLQPLMDNLEGETYEGFEKDPVKYRQYEEAVYQALLDRPERMPVTIFVVGAGRGPLVAGCLRASERSRRKIIITAVEKNPSAYVILQERAALEWGSSVKLVFSDMRSFHPREQADIIVSELLGSFGDNELSPECLDGVMRCLKPDGVSIPSSYTSYLAPITTSKLHAEVTRPVPLGTSSTSADYKPAESPYVVMFSAFHILSASTGQEGGERVQECWSFVHPNPRIIFGQDGQFSQGLPLTNSHNTRSAHLSFHIPYSGVCHGFAGYFEATLYKNVGLSIHPERAAGDMLSWFPIFFPLVDPIYLPASSSIDVQMWRMTDTSKRKVWFEWAASAYMTIPSPIITPSPNPNTTTVTTASATGGGARTSYDPQTTWMAMPSPLMDDGIFHSAPSPMIGSTPHLKNGTSPTDRRNSGRMPNAPDEEGSNQQSHTSMSMVMNRVLINQSKLHNPGGRTSHIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M923</accession>
    <name>A0A2X0M923_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C004g02853 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C004g02853</name>
        <name evidence="2" type="ORF">BQ5605_C004G02853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY68127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M923"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY68127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="289" mass="30005" checksum="6BD2E901498B5D30" modified="2018-09-12" version="1">MSTPATATIAEDELMDLFASDTFSLESARDRDLMALSKVLQTSLPSSPPLAHAIVPTSVTTGPGASSGSSSRQFGASGAQAQWITSHQGYGNGYGSDYPHEASSNNGWRPDASISASAYLHQGAPTCTPSSSFNPPQAGLGAVGAGSHFGQVPPPPTPQGTPMSYYAHLPSFNLDSSSRNLSASPMNGMAVNAAPSPGYRAPAVSRERAPADIPANEWSSRLRSASSAGEYAIRPPSYEDATSVTRMSRSCAAPNGRGRQVNDDNDDAMMGERESGDGSSTSQGWPARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MAT2</accession>
    <name>A0A2X0MAT2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C011g06665 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C011g06665</name>
        <name evidence="1" type="ORF">BQ5605_C011G06665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MAT2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY12956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="190" mass="22043" checksum="50D6DDB7FD708F70" modified="2018-09-12" version="1">MSVELLPLKLNRHREDRLIKTELEETSALYRQNTRRALTLAMADERSDYIGHVSRGKIAEAIQLMRLKPMFSVQLNKTSSDQIKKQRDPLSLMITFLNNSLAFCDKHIMFRCLGVTFVRIRNAEQRDAKDKTCRAYKQFLSGVADIIVQGYLDSPLGGTFDWRAYIWNTYVEPLRKESLSRSPTLRNTII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MB02</accession>
    <name>A0A2X0MB02_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C010g05872 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C010g05872</name>
        <name evidence="2" type="ORF">BQ5605_C010G05872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MB02"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="502"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY13470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="637" mass="69206" checksum="2E66761C508BAE46" modified="2018-09-12" version="1">MTTRAGATTATTYQPYALPPRPAAPIILSAMASPFEPSSPMGIAPTSATMDQPTAQDWYILRSLHQQIYAYQHALFRPHDGPPAIAPVPMHVAIPPPPNPSSSSFPFALPSGSPPSPLPSGPLPTNLDSPHFAPGLTPGMEMGMQASPEQRQPQLQPTRTRKISKSKKRLEKQLKQGLLRRKQLQQENILLNYDSDSAPTANKILPVSSTTIVPPAISETANRASGSTPAPGLGLPSTDSTPVVPLAEEVLPVGGATLTTASEDQVRSEEILRAMLKGGLARSKVPSTKQSATTSNSATSSLPPNSTTTQAGNENVAIANGAKDKGKGKASPQEIEVITLDDDDDEIEEGEIPVDPVERRKSLNTQSPTTKKTTAVPIPIPFPPPRPKKRRKSFEVEIEDMDESPPRGDFEYDQVPRGPRGYDPATSPSSHVIMASPPPLLAPPWPARMYDRWADQEPGEVVRPSYESSQSLSNPVPRYPPQPLAPPSPPSRQHNRIERPPHFQQSSLQQLLPPQRPPPSHPPPPPHDDLAHSEFERESYPQYRAPSDEQKRTRSPPNVPPLAFAYDPRLSKMGSVPLEHTPPPHPYHGYEPPPPQGSSHLHPQQYYPGQAGPPPSSYLLDPRPPPGFYGTNSRPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MC19</accession>
    <name>A0A2X0MC19_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C004g02779 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C004g02779</name>
        <name evidence="1" type="ORF">BQ5605_C004G02779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY67483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MC19"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY67483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="204" mass="22328" checksum="4F2900A688E732B4" modified="2018-09-12" version="1">MSPSQGLFYYPGRLRIPEASIITELVTLYPHELVLLSISDAGIHPTLQGQVVRRRAIQEQEHAIQAASLVINILSDVEASVVDQVKSSLYSGAGCMHSLVDPPPGPMIISAVISFYHALDAFPYTTQSKGYLPLSKPPPSSTKTQSSTSLDSAPIEIAELHLLPGVLPPDQSENAGVDLCKEKDPNVMRFREMIERRVERLRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MDD0</accession>
    <name>A0A2X0MDD0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C004g02937 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C004g02937</name>
        <name evidence="6" type="ORF">BQ5605_C004G02937</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 14-3-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY68987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MDD0"/>
    <dbReference type="STRING" id="796604.A0A2X0MDD0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.190.20:FF:000002">
        <property type="entry name" value="14-3-3 protein epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023409">
        <property type="entry name" value="14-3-3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000868">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00796">
        <property type="entry name" value="1433_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00797">
        <property type="entry name" value="1433_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="5">
        <location>
            <begin position="5"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="247"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000868-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY68987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="263" mass="28994" checksum="4C4ED2F86DD27AB7" modified="2018-09-12" version="1">MSDDRSENVYMAKLAEQAERYDEMVQQMKSIASLDSELSIEERNLLSVAYKNVIGSRRASWRIVSSIEGKEEAKGNTTQVAAIMAYRKKIEGELANICEDILKVLDDHLIKSAESGESKVFYHKMKGDYHRYLAEFAQGSTRSSSSEASLEAYKTASSIASTELPPTHPIRLGLALNFSVFYYEILNSPDKACALAKLAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDLQDAPAEKEEAAPAAAGEEAAPTGEEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MDR9</accession>
    <name>A0A2X0MDR9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C004g03067 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C004g03067</name>
        <name evidence="2" type="ORF">BQ5605_C004G03067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY69826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MDR9"/>
    <dbReference type="STRING" id="796604.A0A2X0MDR9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY69826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="65" mass="7219" checksum="A9FD1004123C6F31" modified="2018-09-12" version="1">MNCKRCRRRELESSKNERTDQLDALGRAKRVMYGRFGAPEDKEEKKQGAVGGAIANGNANADRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0ME62</accession>
    <name>A0A2X0ME62_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C005g03501 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C005g03501</name>
        <name evidence="2" type="ORF">BQ5605_C005G03501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY76577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0ME62"/>
    <dbReference type="STRING" id="796604.A0A2X0ME62"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY76577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="261" mass="29075" checksum="28E1554A3E9ACDE4" modified="2018-09-12" version="1">MLTEYLPTARLVLSWLIIVSALLDSGFSAWLIGFQALRTHGYQKPVPAILVISFFALCFQPFFLYSKAFNTSRAWTTKLALFVKSIACELIVTGALGGMMLVSVADLSSDTPGLLSSCGGYLMCRLLTAVFALAWLPPYNPNFSNVLFLGLSFTLLLISFLYFTIKRRRAIPALTVPFGGVNWAEYSIRRRRAQQTPIPLRASPRTDEYKEPLDSGRGQVDEVFVVVDTTDSEKAEQASTGLGLHERRKSRDIDVRMSVQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0ME77</accession>
    <name>A0A2X0ME77_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C009g05714 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C009g05714</name>
        <name evidence="2" type="ORF">BQ5605_C009G05714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY84700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0ME77"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY84700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="38" mass="4333" checksum="736C462F189A8BD7" modified="2018-09-12" version="1">MRARNSWSPYGKTPPFPTGLHSQKSQQFQAMRNQKGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MF16</accession>
    <name>A0A2X0MF16_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C008g04942 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C008g04942</name>
        <name evidence="1" type="ORF">BQ5605_C008G04942</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY78764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MF16"/>
    <dbReference type="STRING" id="796604.A0A2X0MF16"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY78764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="144" mass="16097" checksum="76CD1E84D728DFAC" modified="2018-09-12" version="1">MHHCFLLPSHHNPLHLHPHYALTSTPSPRNMSGKSLLVVLTSCDKLINDRGATGWYLPELAHPYYVFKKAGLKLTFASPKGGEAPLDPASVKAFSEDKECQEFLKDEEAQKLVKNTHKLSEFKEKDFDAIFYVGGVSPIPQARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MF62</accession>
    <name>A0A2X0MF62_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C008g04982 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C008g04982</name>
        <name evidence="2" type="ORF">BQ5605_C008G04982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY78883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MF62"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY78883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="87" mass="10166" checksum="73D2A512B1D9D317" modified="2018-09-12" version="1">MHPSYVMPEDSLGTHQAAEESGTSVGEVIIPFRTVLGFELIGCWRKMRCHYTGIFLFGFGMQWWTSGQRFFRHVNRFDAYALWSEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MFA1</accession>
    <name>A0A2X0MFA1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C014g07477 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C014g07477</name>
        <name evidence="1" type="ORF">BQ5605_C014G07477</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY18805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MFA1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY18805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="726" mass="82024" checksum="A43E3DB6B2914D8C" modified="2018-09-12" version="1">MTPSSFVNAFKRHQVFIFPPIFPKGHQKVFDLPEQRWNAWWKALRKVRRVHSDAEDTGHLLSLGSLHPGSQVASPTSPHPNNRSTSCVMCLSEAPECLVHLAVGCPFARRLWSALSPTPHPVFVGFVCPVVSRSDRLVELRVLFFHSIWKLCRRRRFSSDLLEPITETEFEGLRASIQESKGRLVSLLTRATRHRPRSWHPITGTLYSTNVSTKVFKMPVIINIEPNFALTSEEFAILSPVADLRLVDLLVYDLPAPDASLRLALSKDDPRHFDALPRPSKQSIGKFSDQSFISLACLDGYRSIVVSGSSMRLPLDASALWAHLDKAEKIRYIIHNIQEQVSQLANADAIREHELASARHHLTRIRWTAVDRVYLRGRSTRLQDFLQVLSVAPNVNEAGLNQVLDRLRLVGSEPLPCVMRREECDALLSVTALDIDQEALIDAVDAGFDQADAEEENRQFQTILAEACHEHEQSTRVPNQWEAPPYPRDLLEKGALYSVPTLDLDSLLARRRAHQCRHLEKIKFKGGAQNVASDQPFAQNRTEHRGNKTLHEQATTAIITEGRSHDKMKGRQEVYGQIMSNHVLVRAVDGDVSALRSLKVDILVVYGIPEEPMGLPSGEQCGERLAIGIGMPNYYLLRNIYKKSSTTYEKLRVIAPGVYSNLSHQGNTRIRQVDGRCIINSLKPDLSSINYEVKDSTRSNWRDEGEIHITVNQEKRYRLLQNIKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MG36</accession>
    <name>A0A2X0MG36_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Uricase</fullName>
            <ecNumber evidence="5 8">1.7.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Urate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C017g08319</name>
        <name evidence="9" type="ORF">BQ5605_C017G08319</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5 8">Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 5 8">
            <text>urate + O2 + H2O = 5-hydroxyisourate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:21368"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="EC" id="1.7.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Purine metabolism; urate degradation; (S)-allantoin from urate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 8">Belongs to the uricase family.</text>
    </comment>
    <dbReference type="EC" id="1.7.3.3" evidence="5 8"/>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY19798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MG36"/>
    <dbReference type="STRING" id="796604.A0A2X0MG36"/>
    <dbReference type="UniPathway" id="UPA00394">
        <property type="reaction ID" value="UER00650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004846">
        <property type="term" value="F:urate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019628">
        <property type="term" value="P:urate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.270.10">
        <property type="entry name" value="Urate Oxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002042">
        <property type="entry name" value="Uricase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019842">
        <property type="entry name" value="Uricase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03383">
        <property type="entry name" value="urate_oxi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874:SF1">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01014">
        <property type="entry name" value="Uricase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000241">
        <property type="entry name" value="Urate_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00093">
        <property type="entry name" value="URICASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00366">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="3 5 8" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000241-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000241-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY19798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="334" mass="37183" checksum="DE66B64FF48A737F" modified="2018-09-12" version="1">MPYLKHAKYGKDKVRTFRIVRNKDGIHDIAEYIVQALLEGSVCSRSCLPHQYVGNSPDKTFCIRSDIETSYTKSDNSVIVATDSIKNTTYLFAKQSPHVLQPESFALDLASHFVETYSHIHKAHVNVIQLKWSRIPVAGKAHKHSFVRNGDEKRFTNVTVDATKGKNAATATVTSGISELLVLKTTESSFENYVFDKFTTLKPVDDRIFSTSVDCSYSIPIPTSALTSASIPKLGIDFERIFKSVETTTLEIFATHNSASVQATLYQMCEKILADHKQVAEVSYKLPNKHYFAVDMAFFGLKNTDPKDAEVFMPVDAPSGLIIANVTRDATSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MGF3</accession>
    <name>A0A2X0MGF3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C009g05433 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C009g05433</name>
        <name evidence="2" type="ORF">BQ5605_C009G05433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY80996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MGF3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY80996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="192" mass="21246" checksum="7C0231917B15D662" modified="2018-09-12" version="1">MYSATEREPTGRSKAVVSRTAGGSDDPPLQRGAHLDDLRLELVTPLAFPLQLFHSGGLFLCQACTFLQKRCLDKFDPLFSLGLASIHHLDQALHPGHLEDERTLIRLSLLLDLTQLDGQLGIAFLQSHMGGLQGRMRVPQRGFVLLQGRELVVQAGDLHVRRASCGGVFDSNAIEFFGKERFVGFERGDVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHZ2</accession>
    <name>A0A2X0MHZ2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C009g05671 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C009g05671</name>
        <name evidence="5" type="ORF">BQ5605_C009G05671</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY84030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHZ2"/>
    <dbReference type="STRING" id="796604.A0A2X0MHZ2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045717">
        <property type="term" value="P:negative regulation of fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045151">
        <property type="entry name" value="DCAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574:SF40">
        <property type="entry name" value="WD AND TETRATRICOPEPTIDE REPEATS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="53"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="100"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="537"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="542"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY84030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="604" mass="66834" checksum="E7AF0E0C44E88D05" modified="2018-09-12" version="1">MSITLSSPTAAPRSTTKRSSTLADLALQDPTSSRIRLLPPHALSAKYTHSTPLSAHHSCVNALAVSNLGGQWLASGGDDKRVLLWRATADLTQEQPRASYIGSGSNIFSIAFSCDDRKLFCAGNDHNVRMYDLEAHPPSRSNETERGHRASRMWEAHDDAVHRVRCHPMNPDLFMSASDDGILNSYDLRVPGGRVNVGVVNVLGDPTAELCDVAYHPQQPDTLFATANSRGALLLHDTRMTTSPTYLLTKTFAVQEFHSNLIRYSSGSNTTASVETASPSISSISFSPNGSLLSATLTGYLPTFYEISSPLPLFTVSSPPPPATEVTSSSRTLEDTIPMYRNGVTVKHGGFGGDESGGGALRYAEGSDDFRVYVWDLPKSYEDLKAQRKKWQEGEQMPEGVDDAQARVAFRGSNPDSSRTIVPSISIPSSILDPHRSIVNSCLFHPTLPLLFTSGVEKTIWAHSPYPFSESIYPVPRTRRKPNPVVSWLAMMSPVFERVVENESQEEKERRLRAEDREVLEYFDAIAIGDREIWRSAKLGSNEEEEEEEEDDDDEEEDEEEEEEDSEEEFADELAHSEEDADEDLEEQLVVQDSDSGVDPDEYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIP2</accession>
    <name>A0A2X0MIP2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C028g10495 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C028g10495</name>
        <name evidence="3" type="ORF">BQ5605_C028G10495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000080">
        <property type="protein sequence ID" value="SGZ12321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIP2"/>
    <dbReference type="STRING" id="796604.A0A2X0MIP2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025444">
        <property type="entry name" value="Monooxy_af470"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13826">
        <property type="entry name" value="Monooxy_af470-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ12321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="313" mass="35455" checksum="EB2D29427A917A3D" modified="2018-09-12" version="1">MANSSAHLISPDHPYQKTYASRPKATYGTSRRPSPQMGLAMLKDTIPLTTFLGLGALLQYLVTLVSPPTWWWTKWVLPLLLILAPWVKPTMIHYGLSSSPDHDRVMPGKWMARMPGGEEDPTTGRVQSPEFVIFMIGARFHGPFGRFSSSSKKLGKAFNEMWAQLSADPDSGLLNVDMYLGTSEWRNNKLKTVAVFRSKEDLWKFARGPLHSKVWTDYYNLGGYEDRGYEIWHEMFVVKEGGFDGIYVNHDPSGNTMANIFRQLNEIDPEGTRSEEGDRWKSILVPINSAKTKTSAGRMGQEEYKSEKEVVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIW9</accession>
    <name>A0A2X0MIW9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C028g10562 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C028g10562</name>
        <name evidence="3" type="ORF">BQ5605_C028G10562</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000080">
        <property type="protein sequence ID" value="SGZ13324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIW9"/>
    <dbReference type="STRING" id="796604.A0A2X0MIW9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF24">
        <property type="entry name" value="3-PHYTASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ13324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="514" mass="57561" checksum="748302E8013820A3" modified="2018-09-12" version="1">MTRRRLTQRGAERTSTDPRSHPNLHRLNTAGPPTRAIAAAVIICAAQAQAQAATSTSYLNGLTHFGQYSPYQPSATYGSGSPEWVGKILQVNILQSNGASEPTAKLSAAMQASVKKVAGRPKYSLKEMEFLSYAAGVLASTRYGCKKDDDCEPFIRSSASARVKESSEQWLKGFMSEAGYGVSGSVTFPETKGSNNTLFDNCPNLVDSLPSAQEEWRAVWTPPIIERLQRDEDFGLDSLVRCSSQLVFSDGTRDLLTIVCFAQDIVHFSYMCAFESLAINATFPFCGLFRRSELQYIEYDADLDKYYEHSYGARLARSQAVGYLSEVLARLESDRDYVNADRIQVNHTVDSNPKTFPLRVKFMHADFTHDDQLLAVLTLLGFFQDSALSTTLPCPMRTFVASKTVPFAGRLVIEQVYTPIWEHMSWFRHETVRILVNDKRMDLSKICTKVSNPQPHRQGLKRRVDRSLTRFLRVQDALTYGGTLCEYRRFAATLKKTIEIATKEFEGCGFVPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJ59</accession>
    <name>A0A2X0MJ59_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C035g11445 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C035g11445</name>
        <name evidence="5" type="ORF">BQ5605_C035G11445</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000064">
        <property type="protein sequence ID" value="SGY98140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJ59"/>
    <dbReference type="STRING" id="796604.A0A2X0MJ59"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009880">
        <property type="entry name" value="Glyoxal_oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208:SF21">
        <property type="entry name" value="LOW QUALITY PROTEIN: ALDEHYDE OXIDASE GLOX-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07250">
        <property type="entry name" value="Glyoxal_oxid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="GO-like_E_set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glyoxal oxidase N-terminal" evidence="3">
        <location>
            <begin position="78"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose oxidase-like Early set" evidence="4">
        <location>
            <begin position="467"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="595"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="639"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="601"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="659"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY98140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="696" mass="74047" checksum="13218C26261889EE" modified="2018-09-12" version="1">MLQPFVAWKASIGLGAVVTLVGVLTPFQASSSSMHVVAAASSGRGTGKANTFEIVGETGRLYVIDKTENNTARILGRAAWATEYNLENNTYRPMKVHTNTFCAGGGVLGDGTWISVGGTQAVDKKGKSTGTKEGSYHEEAGGRSVRLLKPTDDGTDEWIEDEYGMPINRWYPSVEILGNGTAAIFGGELWGGFVDAKKEKQNASSYEFWPSRGSLKFSSFLANSGPANLYPLTYLLPDGRVFMQADWKAQILNLETDEEVALENVPAAQRTYPASGATAVLPMTPANNYTVTILMCGGMNPKRDDWDVTQWDIADTPTSNSCVSITPKDGAKWVEDDDLPQPRAMGNFIIMPTGQLLLFNGVGRGSSGYGNLPWAIGQSFAQDPVLQPVMYNPFAPKGSRITTEGLPLSTIPRMYHSSATLLADGAVFIAGSNPNADVTTEENNPTVPFKTEYRGEIFYPSWYDMLRPEASVMPSSFSYGGELFQFSLAASTFTDAAGPDSIRVVLIRTGFSTHAMNMGMRFIELRSTYTVQDDNSVTVNVAQLPPNPNLFQPGPALFFVVVNEVPSIGRLVMVGNGKLGQQPVAKDTVLPASSGKFTLTNSGAGSGPSPNASARPGTNPNPHTLVGAVGQVGSSLSLVESVGPANGSSSMPGMDMSKNKGSMTTSTNTRSSAPKKTLATLSLQGLIVGLGAWLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJF1</accession>
    <name>A0A2X0MJF1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01035 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01035</name>
        <name evidence="2" type="ORF">BQ5605_C002G01035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY29279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJF1"/>
    <dbReference type="STRING" id="796604.A0A2X0MJF1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015968630" evidence="1">
        <location>
            <begin position="21"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY29279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="397" mass="42437" checksum="D8FC4443FCE828D1" modified="2018-09-12" version="1">MQLFTFLIAAAPALTSFVSASALTADEMAVEKRNLFKYCCNGKLWKRDDIESLEKRTFCLRKRTFWIQKCPTTPPCNPLNCPKPSYSLPLCTNDQCDFQCLSGTIKIGSSCVKPCKPLLCPAVANATPVCKDDQSCDFNCKSGFSKVNGKCVPACNATKCPVVANATPVCKDDQSCDFNCNSGFNKVDGKCVPVCDPTKCPVVANSQSICTSSGDCDFNCNSGFSEVDGECVADTPTCDVTKCPSCPNGNGTPICTDNKCDLECNTDFSKKDGQCVPDVPVPTCTKKSVAFYDDFQSTADGEAAVTVASIDACAAYCLSKNCASFDFWDGNQCGIQIGGGGFDGFQYSPGVVHGVAGQCSDFTDKCPEKVAVKACYNKSVCPATSARLRRSHSKRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MK64</accession>
    <name>A0A2X0MK64_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Checkpoint protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C021g09290</name>
        <name evidence="6" type="ORF">BQ5605_C021G09290</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the HUS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000083">
        <property type="protein sequence ID" value="SGZ20634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MK64"/>
    <dbReference type="STRING" id="796604.A0A2X0MK64"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044778">
        <property type="term" value="P:meiotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016580">
        <property type="entry name" value="HUS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007150">
        <property type="entry name" value="HUS1/Mec3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900:SF0">
        <property type="entry name" value="CHECKPOINT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900">
        <property type="entry name" value="MITOTIC AND DNA DAMAGE CHECKPOINT PROTEIN HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04005">
        <property type="entry name" value="Hus1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011312">
        <property type="entry name" value="Cell_cycle_HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR011312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGZ20634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="301" mass="32370" checksum="6D2ADA0A98C0D8C4" modified="2018-09-12" version="1">MRFRATLASPVQFGRLVTSLSPLSKQATIKLKPDSVHLVCLSDTTANGVQVWSQIAVSSIFKIDHDFRLESNSNNEIYLEVSTEALAKALRSAHGATEVTIKLAKKGGQGPDGSGKGARPVLTLSIKTISKGMNPTDISQDVGVRVRKAAEMDLLKEPLCPTPDINIMLPPLATLKTICERLKTISPLVTISANHQGELKLRAESEDANVTTEWRGLLHPRPGEEDPAPTAEPNPSQFFSVTVDSKNLLKFLAAYPISSSTIASLCEGHCAIFYLYLASKGESQGGVLTYFVPAVSTGVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKE1</accession>
    <name>A0A2X0MKE1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C034g11279 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C034g11279</name>
        <name evidence="3" type="ORF">BQ5605_C034G11279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000065">
        <property type="protein sequence ID" value="SGY99320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MKE1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY99320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="264" mass="28497" checksum="F3FF6B4F0D345EAC" modified="2018-09-12" version="1">MGIFASPSPVPSKSDDLLQWLSFDPPLPVQLALVPSICRFIAFLLFLPVIALALTDVFGWVIFKLVLRPLGYASTTRFKDPEPEAAIKLTNPRSRSTSKQRSSSRPRISPTDSDYIDATIDGDSERNGHSKPSNESTAEGDTSSSSDAQDETRSPSRSPQLPHHLTLADREDSYSSSGTSRLNHFRARSVGFDGPLFAVGEELASPGRSDDEPLPEMEEGPVTQMGMSDGSDNEGSGTGGARRRVGPRRGTPSLSFTSLGTEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLM1</accession>
    <name>A0A2X0MLM1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C012g06819 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C012g06819</name>
        <name evidence="1" type="ORF">BQ5605_C012G06819</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MLM1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY16244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="78" mass="9101" checksum="6D93726CB61B88E6" modified="2018-09-12" version="1">MRAINMRLITSFSDIRKSDMRRECSVWTIIVFNEAHSHRSLLHTGDSKSRLTRHRSNLFHLGPNGSCIVFLVSVMRSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLR6</accession>
    <name>A0A2X0MLR6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C024g09838 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C024g09838</name>
        <name evidence="6" type="ORF">BQ5605_C024G09838</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ26117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MLR6"/>
    <dbReference type="STRING" id="796604.A0A2X0MLR6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000051">
        <property type="entry name" value="ubiquitin-conjugating enzyme E2 R2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="11"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGZ26117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="221" mass="24662" checksum="1BC19E7DE77E4059" modified="2018-09-12" version="1">MNSNNRSAMNTALKRLMTEAKNEDSMFTAGNRVPRPHPTTAAHVSVCLTHHPSLGDRTGPISENDFFIWSALIQGPSETPFEGGVFEAELTFPRDYPLSPPKMKFTPPLFHPNIYASGDVCISILHSPGDDPNAYESSSERWSPVQSVEKILLSVISMLAEPNIESGANIDACASSLLLTYSVTRYDTNSPSFFPLQKLYRDNREAYDDMIRQHVRQQLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLT1</accession>
    <name>A0A2X0MLT1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C106g13185 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C106g13185</name>
        <name evidence="3" type="ORF">BQ5605_C106G13185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000077">
        <property type="protein sequence ID" value="SGZ11285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1094"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="992"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="497"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ11285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1872" mass="205568" checksum="893F5947B5CFE5B9" modified="2018-09-12" version="1">MVVTAWIGKKARSFYWIVFCRLPTAQQPALETQPRRDIRRCRGQHEQAMPDPPGAQAPPPDNPLGGNRASDDESLNTLTREPVTGGTANPPAWSTEATQARLDCEKVMQNTFRVLGIVPSGKSTRRLMVLMHDASTPPSQAPLLARAAQRAVRNDAAPASNVIRVIMDGPGSPRGPVQIALRKHFGLAETPFMFARPEGVVLDPEVEKLFSKCVKLNPIVTKATKRFPIARHMYELVFESDQACLEAAAAGPFSHHGKEMVTELPSASPLNHVVQVRFTLPSSSSATPASVLRQSLDDALTLSFGRAGRTQGYTLMQLQRGLAVDPNGDPMAMTEDGFHCAYLRLHADLFQGSTETQKAALNAALPQEIEILGAKYGLRHEFETHYCAVCDRAGHQWGACRKPVSTPATAAPVPGASTSTSTTGFRVAGKNGKHGGPAALNSRASGTNMIQLGPRANPAGAATGNKDDANDDDGGGESVASTEPEGGDTGKETLTRATTGPTKETQTTTAAPVSTPTSPSPSASAPASPLSGGTSESSATSTTSIASTSPRRLRSSSAPGNRRVTRAGSAMILGASGGDGSGGNSSGVNQVKIIRYLKTLRPAPAAILLQEHHLGYNASREGFESAWPGACIRFTPHVLTLIPDGSPLAGHLLSSTPVVFAGAPRLDGRILRSVFRLEELDVEIINMYAPVQEDDRRDFFGLLHFNAPRPKTLRILAGDLNDCPDVSVDRVSITDRAWTPVSHWQTLLSKIAFKALDTVRHVHSCTPAFTRPHYRGRGEERKICSWSRIDYILVQCSWANRLLSASTLFDAPCSDHRPVVATFALPTDFISRLNPTVFDDQDFVASIPGVVDEVYRRLEGTAPLGDVYDAALRAVAVAGHARYRSTRADMRRLRAESQSVMEALEARGEHMNEAERDAYAFAKSRLDQLAVKEAQWLRIRAHVPSVDSREGQSASIRTRLNRRSRQTSIVSLEDVDGTETVDMQEALGIASRHAQSLFTPDPARGDPTNPRRSLLDPIRAAKCYDDDRSDPTFGRRLPRQARVALDEPFTLLEVEAALKKTDSGRSPGPSGIPYELFKALPTYFAPKLLDLFNSIWEGGKMTASLAEGLVRLLPKNKPGANLKSLGAYRPITLRETTYKVLSKVLVARLNGVLGELLPPAQHGFMPSRRSADAGSHLTLLLEKLKSLGTEVFPEGALLSLDQQSAYDRVDHAWIFDVFEAFGFGERFISLLRALYDPETLGVRYLINGFPTELVRLLCGLGQGDPLSCPVWNITFQPFLDALVRRGIALDLQKVWPGGPRAQLTHLAFADDAVVVVESPAGLSKLETLSQTWYEATNGKTNTDKTLVLPLGPNWLRDETAQALPTVQEGRASSGAAMPSFAMAKARAARDRTLSPSGRVFYANAHITSTVLHVLSFDIPPQWFIQAAETALTDFVWGGPRRNTVAREFVFQAREDGGLGLISIGDIVHSVALRFWDAVAGSDEAIWAPLARESWRSLVAATRDFSPWGFFSSTARVEKLYRDSARWGAVVAAARVTLPTIKSELLTLPELLSLPPRLPSLYAEGAKHAYDDADAVAKFAQIADLYWRDEGKGWALVGHRRGFWQHSKEPALQHEHVWSRVGQLLKAKALLPKTALRPARIPLKEAPRPRCFNFFGLTRPFTIRKLRRFVNVVRFPGREDRVKRFRDGTSQSDRKRFWRWLHDRFASAVEQDTHWRLMYDVTPTRKRQHTQGHASSPTCLFCGNDAAVIETVSHYFFECAYSTSFWGGVLRILFDKLGIEDTDVDPSTFTPEQLTMGLPLLRGRGRTTSRWMWVRLACAIGFQRLHLLRWRVHQRFELDKVVAPPSLPSALRAFERDFLSRAGFVPGARDWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MMG7</accession>
    <name>A0A2X0MMG7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C020g09188 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C020g09188</name>
        <name evidence="3" type="ORF">BQ5605_C020G09188</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP4R2 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000082">
        <property type="protein sequence ID" value="SGZ18522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MMG7"/>
    <dbReference type="STRING" id="796604.A0A2X0MMG7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015267">
        <property type="entry name" value="PPP4R2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16487">
        <property type="entry name" value="PPP4R2-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16487:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09184">
        <property type="entry name" value="PPP4R2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="163"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="211"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="235"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="266"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ18522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="357" mass="37889" checksum="AFB49890DA773805" modified="2018-09-12" version="1">MAGGSASNGFTAPSINHSPGFEYIAAYDELLEQIAITNVVDADWRILRDMLKHKLAENINVFLTLGPPWPLSPEDAFKARGGAYDALDQFTGPPFTIQRLCELILYPQKHYNSLPKYLRALMRVVSVASTRSAFNEDETFVEPFASTSATTLDGAPIVTAHHTTASASPLPSPTMPTRRPSVPRSPSSSPGALPVVVPLLSPIPWLIKTSADGDGDESVEEMDLSNTSTAHDFHSSSSPSRSSDGGRSPIRGLGTARRSHSPPSPSQLNNHPGNHTTPTGGVVDEVDPGSGGSEVVDPVALSSATEIAPRPADSLLGAHGSSESLRERFVRASSPRVDLPEENADEGDVEAKAGEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MND6</accession>
    <name>A0A2X0MND6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g02287 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g02287</name>
        <name evidence="2" type="ORF">BQ5605_C003G02287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MND6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY39863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="101" mass="11404" checksum="C9FA4A5DD940E950" modified="2018-09-12" version="1">MPSKGLPPFGACPACEMPPAEPLQVVQMPPRKQGAQLQQKGSLTTKQRASQQSKEGLFEAWSHAQHQPKRRAPQATFDRPRRRPHTLGTRFRGLLSDFWSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNX6</accession>
    <name>A0A2X0MNX6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C014g07649 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C014g07649</name>
        <name evidence="2" type="ORF">BQ5605_C014G07649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY19441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MNX6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="617"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="441"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY19441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="721" mass="78182" checksum="0C0CA01699CF2170" modified="2018-09-12" version="1">MAFQQQRSRPRVQRDSHEDHHHQQALSQTAPHRAPLGVGGHHSDHATSSISAGAASGTDTGAGTGHGAAESTFHASSRAPYTTWNEDDEVLLFGGASASASAADSSSWYAHGNGSTPQAPLAASDDWTLLSAPAHHHRHHHPYQRTLSPAATRSSRSTSASATSSSELGAREGGDLSVSLFPAHDGNGRFLSLSSDSLVNSTLYDRAESSTHASSDANSSSFVRTRRHGPRPIASDGSQWSDVADPDPAEYMRRPPTSVSASAAAPTHASSSLSASWALTEAALSTIPDGSIGRRIVLRRLEDRVVQEEVEHEDDDRQSAGFTSDSSVEDENLPPRERRRRAASRRAATPTARLIPIAPLQSREDAEEDMLCRTPGAESAGLHLNSRRHLRVVPSTYEEHRTHGGLHSSQRSREAYPSPPPEDRLSASKSSVKRRHRQSGRSESSQKRSSTSGSIRHASVRHASVASTMPTIAQLLEEKQMAEARREEVQNQIWLGSLVMGKTMGIDAETLEMVAAAEPLTPEATPTPSRAASPRLRNRTPELENAHGFAALMRHAEQELGTEASKIFRLHEAEDESEEEEDETDTEQSSSKYPTVAWHRMTEPLVFAPRHATIPNEADSSIEASRENPSRSLSTSSLPMYLVGHSLKVSSGRLGPLTSTSPANSEDPVSDSIRLRRRTTSFTNSLNSNSDESPWGGEFDGLEAAIVYWRSLWRRIRGLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MP83</accession>
    <name>A0A2X0MP83_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g02577 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g02577</name>
        <name evidence="2" type="ORF">BQ5605_C003G02577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY41865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MP83"/>
    <dbReference type="STRING" id="796604.A0A2X0MP83"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY41865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="761" mass="82782" checksum="1C37BD4DC724BB7D" modified="2018-09-12" version="1">MASSNETTPIVSSNSRPPTLTRLLATCAPSSWFLPPPYHDGVCHSTATRVQAEAGTTAYDCVARLGGLKWDSPASPGARVLGSFFDILEQHPSLLDLFREELDAINNAPRSRMPRKSERNVEISFHRLLFGGLESATAALLNHYAAITEAVGASSASASTSATRPRYSVRLDQPESALRTQGDAVVYIELEAGNVVSSISIEYKRDNVHHSLAKVRQEGLSHIPILDHGAPVPLQKLEEEESKGADAVATKAIIQCVSSKSRFFLLLSVPFFQIGELVQHQSTHAATASDPVASTSAASALISAATAYSPAPPLKARYSLVLQELARWVEPSPTTMNSDAAETLGADLPRRSLIVSFIALAFTAVIEVPKPDQAVIDTLLNPQFQPPNLPRRRSDPDLDPNYEPSPRVQKASKTSIEATGARRSGRLAGQPPRAQTKDSNRPVTPPISVGLQSDPSFDPLTPVTRIFSSPPASTDWSPATSPLSGSGLPSKSITIVQDRGFVIKASLSSAYWSTMSYTGTSRVELVEIGFDIVSSVPSDSPLASRLPSKPSPASDFIRGLHLSDVVLRWLSENPREELKDDRIPLELLDRFEPTADLRLEKEVGSGSTAGGWLAKVVQVNRPLCSSAKAEAPLVDHPAPNTTYFLKLVTCRYVGSVIRETLFYQHVLPHLPEHLRKHIPQYHGTYRRTNGNGYAMVLENVGKTMNELDFYGSPGELWEIEAAFRELGIIHNDVRAGNVLVRPNNGPLCFVDWGRSYLKLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPC8</accession>
    <name>A0A2X0MPC8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C113g13231 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C113g13231</name>
        <name evidence="3" type="ORF">BQ5605_C113G13231</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000107">
        <property type="protein sequence ID" value="SGZ30293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MPC8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="770"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ30293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1564" mass="175351" checksum="F5B318D91E8F646E" modified="2018-09-12" version="1">MSPVASKRSKKNASPTRATNNSPRVYPARSQSSTPTASALCGFIVAANPFASLAGDVAEEAQGEPAQALEDDEDAMSVVEAQLEPQQEVPPLEPSDLSDLQDRGAEGNQEEHTETSDAEEGESQSAETGSMPEVVSTTPELTRFRSASHHQLDMDGLPDDWMNRVSDRERKQDAGLYDEITELDRTPSVTGWMPSPSPGPVCDPEPEPKQEVEEGTSQGLRRSERIQRLTSVARTSDWNESTAADPLPSPTFGPMLSIKGAAAATKARSGFNTPERRRLLLSYLTSLTPPPSAILLQEHNVPKARQSHIRHEYAQSHQGEAYFSQHCLTLIPSSSPLLGGHRRTRQSLGGRLLVTTFDVRGSTDVVELNNIYAPVQPAERLLFFTSLHFRATVSSHIRFIAGDLNDCPIPAVDRAQQVDRPNTHHWPVLMSRLDGAYTDAIRLMHPLSPATTRPHLSKDGQLISRARIDFVLVQRRHERRIVSASTLYNISRPMSDHRPVMVTFRLRASGAEVEEELCLPQAAHFLTRINSSTFKHAEFKEFVTPLLEQAPSGDPVADLQRVLSESRVQALELSRRLFRERNALEMMLVSRLQDIESRRVLSPFDIIDWTNTHDALSKLVNERARQSRIRAHVPEIASEERLSRPVHAKLAARSRDVKFQSIRLADGELTTDMERTLEHTHSHFQQHYLVEAKDPEQVVTMRDELLGPIRSARPCDDPLSDARFLRRFSNSHVDILAEPISEAEVLAAIRTTHEGRSPGPSGSPMRSYNELITRGSLTPQQSQANVRLLFKHNKPGAARCDLKSYRPITLRECDYKIFTKVYVARLNRILPDVLPAGQHGFVKGRRPADAALHLRLLIDEIRGRGAEFPTAALLSLDQSSAYDMVEHDWVFAVFEALGAPEPFQRVLRMLYNGETSTARYIVNGFLTETVRLLCGLGQGDPLSSSVWDVVFQPFLDSLSRRNIALTITLPELAHRPQTRCITNLAFADDAVVAVAGPEAIASLEALARDWRLATNGRLNTDKTVVMPLGATLWDRADLSKLSFVAPDESLPWIGLQFAPDGNNRLGFHDLERRVDRVILSVRDRWMTHHTRAFYLNRYGISKVLHSLSADIPPSDVIKSIERKLADFVKGGPRRSDYKQSVVFTARARGGLSVVSIQDVVDSVSVRIWDVLAGGSTAIWGDLARSSIRRALPTFDFAADLWTWRNADAPRELHPRWRAVLSVAERYPAVVDPAKLSDKRLAKHFSFERTIADIYARAQYPAAPTVPWTPEKHPQGDGSELSNLWQWKRDQVQAWIQVAGDRFIPPLPPPVPVLARRPPVIRVVGAPGARAGGPLEHILPRATPVGMPDQRLPLPSAPLLANQWRMLSLDRPYTIARLRRVINHRRFDDTQRPGSLATPKERRLFWGWFHTGPATAREREVHFKLAYHFTPTRKRQFVQRHGDSACCLVQACSLAGVEDDFTHFWHDCPDSSQFWQAARSIICDALGVVSILDLDYTALQIEHGLPRLRARLPTSKKRPIRAFIALALDTLSNRRWDLHRHARAMSSMDKEMAGLKERLELRLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQ66</accession>
    <name>A0A2X0MQ66_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C024g09922 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C024g09922</name>
        <name evidence="4" type="ORF">BQ5605_C024G09922</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ26474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQ66"/>
    <dbReference type="STRING" id="796604.A0A2X0MQ66"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054293">
        <property type="entry name" value="DUF7029"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055647">
        <property type="entry name" value="DUF7223"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22974">
        <property type="entry name" value="DUF7029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23865">
        <property type="entry name" value="DUF7223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016143163" evidence="1">
        <location>
            <begin position="19"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7029" evidence="2">
        <location>
            <begin position="89"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7223" evidence="3">
        <location>
            <begin position="288"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ26474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="627" mass="68470" checksum="BCE7C36A819CBE9B" modified="2018-09-12" version="1">MLISIWIAAMCLAAVARTDKLTPYPLYDTEHEPPDDTFYPMAVEHTGTPDLAALSSALDLQDQEIFVWAGEKGRTGESMMAVMELDTHGTEKQVLNMQRFASLVAHVECGSIETRIEFKSREVFSYAATSWSWVNSHPDHIFVLFTHWQGCLTDEGNFKPFHFHTLVTDAASSTITLQGATKIWKEAAHTFTLEVGDPSPSPKLISDFKLARSVRRRSAAGRMDRGGKVDFRQFSNPVPSFQPESWSFKKNIWNPLRNIWDYLIGRKRLAVSFGSAGLSAHPVAAQPGISASSHCKGCSIHGSLGVHFVLRVSGSTPIRVGVSMTAHNVGAKAKLDFNVKGRTPASFAWGRTLATLAIPGFTFEIPNIFWAGAQLKTGYGFATSKLDGEFELGTGVDIEIPDGAMVYFDFLGPNDASTGSWSPQLIKQPIDFVGNGHGVLAGGISSGIGFSVSLFKMSFTLAAVQFKFPSLSFHIGLNSPGTKPCGQIVHSETTEVDSYLSIGVSVKTGYSGGDFSIGGSSRLKRHDHLDEANSFNASLLEGFLDEAFPIDDPKTWLGALPALEDNKEGIDVTEEQASMDKRAFKGVGVSYSKNLWSHRWPWLQPKCFASRAVSVRSHPRELLGLNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQI9</accession>
    <name>A0A2X0MQI9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C026g10196 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C026g10196</name>
        <name evidence="2" type="ORF">BQ5605_C026G10196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ27817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQI9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ27817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="86" mass="9384" checksum="678CCA391C4576B1" modified="2018-09-12" version="1">MPATLSEFRGLHQRLNATGRSVKKAKHHQLPAHNQSGTRSVETSGVDDSARPPPLARDVQRVRVIQAQMVMSDEAQLAKEVGPFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MRP9</accession>
    <name>A0A2X0MRP9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C050g12471 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C050g12471</name>
        <name evidence="2" type="ORF">BQ5605_C050G12471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000097">
        <property type="protein sequence ID" value="SGZ29665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MRP9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016116051" evidence="1">
        <location>
            <begin position="21"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ29665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="209" mass="22920" checksum="294B89B7007BEB55" modified="2018-09-12" version="1">MLLLWSHLAALTLVASLATCSPLTAPPLKALDNGRSFDPAPGSEAVADFTKQNISGSHTPDFRHPSTLTRDVSHVAPLALRPRSLPRPRFPLLTPPAIVYPRGGETYRPGDTVTYRWKPTHSPEKADLWLTCRGSEAQEIRFIDRDIPLNTGGNTTTIPNDISWNVLNGEEGANANVSAFIYFGVSRTSYTQDQGVFGKHTHSFTIKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MSF8</accession>
    <name>A0A2X0MSF8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C050g12470 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C050g12470</name>
        <name evidence="2" type="ORF">BQ5605_C050G12470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000097">
        <property type="protein sequence ID" value="SGZ29662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MSF8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ29662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="198" mass="22151" checksum="958D9563DF15C271" modified="2018-09-12" version="1">MDRAISLQTLSHRDHVTQSSHRSGELLQNDTDHYFFGCFDSRNVWIATRGVLCNALGCDTIDDADYTTLQRLLFGLPKLKAKLSDQEGAGRTIKIFTGMGLEMISSGRGRMQKHGTRMESMERKRVHQATKAVERQEGQRHTLLEKRRNASKVEQEGSAAERYPKRVMYGHFGAPEDEEKKKQGTVGGAIANGNANAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MST6</accession>
    <name>A0A2X0MST6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C118g13266 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C118g13266</name>
        <name evidence="3" type="ORF">BQ5605_C118G13266</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000108">
        <property type="protein sequence ID" value="SGZ30320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="980"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="897"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1577"/>
            <end position="1603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="366"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ30320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1828" mass="201036" checksum="0915F11F65375DFF" modified="2018-09-12" version="1">MVLLYDPSSPPSQAPALARAAQRAVRNDAMPASNVIRVIMDGTGSPRGPVQIALRKHFGLAETPFMFARPEGAELDPEVEKLFSKCVKLNPIVTKATKRFPIARHMYELVFESDQACLEAAAAGPFPYHGKEMVTELPSVSPLNHIVQVRFTLPSSSSAIPASVLRKSLDAALTSSFGHAGCTQGYTLMQLQRGLAVDPNGDPMAMTEDGFHCAYLRLHADLFQGSTETQKAALNAALPQEIEILGAKYGLRHEFETHYCAPVSTPATAAPVPGASTSTSTSTSTTGFRVAGKNGKHGGPAALNSRASGTNMIQLGPRANPAGSATGNKDDANDGDGDDDDDDDGESVASTEPEGGDTGKETLTRATTGPTKETQTTTAAPVSTPTSPSPSTSAPASPLSGGTSESSATSTTSIASTSPRRLRSSSAPGNRRVTRAGSAMIHGASGGDDSGGNSSGGYRSESLTVLTFNVRSIKNAVNQVKIIRYLKTLRPAPAAILLQEHHLSYNALREGFESAWPGACIRFAPHVLTLIPDGSPLAGRLLSSTPVVFAEAPQFDGRILRSVFRLEELDIEIINMYAPVKGEERRDFYGLLHFTAPGPKTLRILAGDLNDCPDVSVDRVAITDRAWTPVSHWQTLLSKIAFNPLDTIRQLHPITPAFTRPHYLGRGDKREICSWSRIDYILVQRSWANRLLSASTLFDAPCSDHRPVVATFALPTSNAADAEPPPALPTTSEFISRLNPTVFNDQDFVDSIPGVVDEVYRRLEGTAPLGDVYDAALRAVAAAGHARYRSTRADMRRLRAENQSVMEALEARGEHMNEAERDAYALAKSQLDQLAVKEAQWLRIRAHVPSVDSREGQSASIRTRLNRRSRQTSIVSLEDVDGTETVDMQEALGIASRHAQSLFTPDPARGDPTNARRSLLDPIRAAKCYDDDRSDPTFGRQAALKKTDSGRSPGPSGIPYELFKALPTYFAPKLLDLFNSIWEGGKMTASLAEGLVRLLPKNKPGANLKSLGAYRPITLRETTYKVLSKVLVARLNGVLGELLPPAQHGFMPSRRSADAGSHLTLLLEKLRSLGTDVFPEGALLSLDQQSAYDRVDHAWIFDVFEAFGFGERFISLLRALYDPETLGVRYLINGFPTELVRLLCGLGQGDPLSCPVWNITFQPFLDALVRRGIALDLQKVWPGGPRAQLTHLAFADDAVVVVESPAALSKLETLSQTWYEATNGKTNTDKTLVLPLGPNWLRDETAQALPTVQEGESFKWCGYAFFRHGDSKLFWTHVLDRIKAKARAARDRTLSPSGRVFYANAHITSTVLHVLSFDIPPQWFIQAAETALTDFVWGGPRRNTVAREFVFQAREDGGLGLISIGDIVHSVALRFWDAVAGSDEAIWAPLARESWRSLVAATRDFSPWGFFSSTARVEKLYRDSTRWGAVVAAARVTLPTIKSELLTLPELLSLPPRLPSLYAEGAKHAYDDADAVAKFAQIADLYWRDEGKGWALVGHRRGFWQHSKEPALRHEHVWARVGQKLKAKALLPKTAVRPARIPLKEDPHPRCFNFFGLTRPFTIRKLRRLVNTVRFPGKDGQDRALPGGQPQEPRVKRFPEGTSQSGRQRFWSWLHDRFASAAEQDTHWRLMYDVTPTRKKQHVQGHASSPSCLFCGNDAAVIETVSHYFFGCAYSASYWSGVLRILFDKLGIEDTDVDPSTFTQEQLTMGLPLLRGRGRTTSKWMWVRLACAIGFQRLHLLRWHVHQRFEKDRVVAPPSIPSALRAFNRDYLSRAGFVPGARDWELQSLFLDKARSFYWIVFCRLPTAQQPALETQPRRDIRRCRGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MTP1</accession>
    <name>A0A2X0MTP1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="19">BQ5605_C045g12214 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">BQ5605_C045g12214</name>
        <name evidence="19" type="ORF">BQ5605_C045G12214</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000115">
        <property type="protein sequence ID" value="SGZ31613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MTP1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="18">
        <location>
            <begin position="212"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="444"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1133"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1139"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1164"/>
            <end position="1181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="SGZ31613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1181" mass="131428" checksum="8381029FFD8EA0B7" modified="2018-09-12" version="1">MGRELKKLVKGTRSLSSLTDSEFKQKGSNGVIAGEDKLLKRLSKARALHPAVGRGTLTAEFALADGTTSKMTIADVLHVPNFVVNLISGPSLCKQGVRIEMEEGRCEFSKDGQTFAIAQLIGSKYIFQARLSNLNPTEAQSLTVSVRSNSADREIWHQRFGHLNMPYLLEMEGKETVMGLNIKGEDFDVAKCHGCMQGRGVHTNISRGRASRADKPLHTIHADLWGPVRHESFAGEVMVLGLVDDYSRFRWSFPIGKKSSVTALVVEFIQRVERSRDCNVAIFHSDNGGEFVNNSLKAFFRERGIEHRTTVPYAHYQNGVIERGWRTMFETVRIWLLVSGLPLSFWAFAATAFTYVSNRRPTAALPGSTPFEMYHLRKPNVSRFRVWGCVAYVRIAPERRASKIEPPRVKARFIGYAEQGWMFWRPDTNTVFVSDDANFDESSFELHRGNSDDADLREDSPTTLFGNPPTGSLDIDGDDAVEQDFSLDGAGRAQAPGTDDRAMAPIAARRAFAPDGDSRDNTPPVGRARAPDQFNTAMVKSLLPLFPPVEHRRGGAEQQAMFVDLGTILGDVIPLNELPEWEQVLSVVVNLEECNGWTNLSSIVQGSTEGICGIEELEAYQVWTGSPDEPTYKQAMAGEDREDWSISLMTEYSILNGMNTWDKEATDPPPGVRAIPTKVVLVRKRNDKGDIIKYKARIVARGDLQNHHGETFSPTARIASIRMINVIAHVKGYRRLQFDVNSAYLHGHITEPLWIKLPDGSTHRLRKSLYGLKQSGREWNKVLHAALVDRGFKRMEEDFGVYRRVRNIGGVDRTTLLAIYVDDGLLAGDDDLEGFLSEFDQQFKLKRGEVELFLGMKIATDDASGIMTIDQCHQIETILNNHGFANASAVATPTSDSDQHSDGGTAHLKLNYRQVVGELLWVSGCTRPDISYAVTQLSRHCADPKPEHFRQMRRVLRYLRGTINRRLEYNRHLGIDVTLYCDSDHAAEKSERRSISGYTVIMAGAAITWASKRQVSVATSSVQAEYQALSAAARETLWIRSLLFSLGFPPSSPTIIHGDSTGAIALADHPTSHATTKHIATHYHFTRELVSNGIIELRWIGTKEMVADGFTKGLSRAPHESFVRMLGMVDAPRQGASAEHAERDRNDVYEGRVEEGLGSRSEHEVEEEDDAELGDGDGESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MUE0</accession>
    <name>A0A2X0MUE0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="4">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">BQ5605_C002g01737</name>
        <name evidence="15" type="ORF">BQ5605_C002G01737</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="4"/>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY35191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MUE0"/>
    <dbReference type="STRING" id="796604.A0A2X0MUE0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
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    <sequence length="389" mass="41943" checksum="8A040DC0008D7CE0" modified="2018-09-12" version="1">MRDGSSIKLLTGNSHPELAQQIAKRLGIPLTKCTVKKFSDNETSVSIGESVREEDVFIVQTGFNPSPYPFGSKARHYGDSSLEASRPGTPNGSRPTTPLPTSASTSSLHVPNSKSQPGPEPFNDPNDLLMELLILISACKTASAKRITAVIPCFPYSRMDRKDKSRAPITAKLVANMLQIAGCNHVITMDLHASQIQGFFEVPVDNLWTEPSMIHWVKENIPDWRNAIIVSPDAGGAKRATMLADRLDVDFALINRNRVKGAAPNAEARMEILVGDVKGKVAVLIDDMCDTGGTIKLATNALLASGARKVYAVVSHGLLSGESMSELARLPLEKLVVSNTICQTEHLKQAHGKLEVMDISPVVAESIRRTHNGESISLLFSEGGASLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MWT2</accession>
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                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <source>
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    </evidence>
    <sequence length="90" mass="10135" checksum="9C535BB47A1EB9B1" modified="2018-09-12" version="1">MLKQGRISSSFGRFVQETALLQTPFNILLQYILGEYTHLLVPDVAIRISTCRVQTRDLNSSGELSHPSYIRSLPAVRALKVVPTREVFSC</sequence>
</entry>
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    <accession>A0A2X0MX99</accession>
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                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <keyword evidence="9" id="KW-0157">Chromophore</keyword>
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    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0600">Photoreceptor protein</keyword>
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    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PAS" evidence="17">
        <location>
            <begin position="385"/>
            <end position="442"/>
        </location>
    </feature>
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        </location>
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            <begin position="1010"/>
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        </location>
    </feature>
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            <begin position="34"/>
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        </location>
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        </location>
    </feature>
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        <location>
            <begin position="1052"/>
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        <location>
            <begin position="1109"/>
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            <begin position="34"/>
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        </location>
    </feature>
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        <location>
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        </location>
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        </location>
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        </location>
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            <begin position="1052"/>
            <end position="1083"/>
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    </evidence>
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    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="SGY45329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1145" mass="122798" checksum="9CE435B85B75B500" modified="2018-09-12" version="1">MSSSYHNSHGDGSNGSAEYSAYTHNIYPHDMTGQLQSHPMTFSTSNGSNHGLDDPTPAHDTYSHLLDGSSPHTHYDPSVPVALSGIFDSASYPNEDRKDLVRAQQQQQQQQPAQEEPNLGATASMSNYFGPNSSQLNQSHSQSQKDMMAQMICFANAYEFASPAPATSSCASPNTLALVPDSPSRVQRTPLFSVPTTFIKELAVRPSAQGRSKSHSVAETFGMMGPPPRPLVRSQTMTNSQFGRMSAPASPQQHSSPNGTSSDSYSASAFVPAPVPQQAPQTTIQRPVKQQAQTGASPQKVDRRPSLPNSLASTFSMNPTRPSSPFDAASRGLPTVPAQFGPSASGTWTSPYATNGFDMVKILSRVASRPNPQLALGPVDLGCSFLVVDARKFDQPIIYASETFARLTGYSSEETLGRNCRFLQAPDAQVVQGEKRKYTDGNAAYHIRRHIVQGKESQASMINYCKGGRPFINLITVIPISWDSDEIAFYVGFQVDLVEQPSAIMDKMKNGSYAIDYRISNIPREMSAPSTETISVDHLEELTGGIHDQPLALASPGISSDPSVSAIADMMDPSKVLDQVDGRGPAGLANESGRKLFNRMLLENCDDFVHVLSLKGALLYVSPSSKQLLEYEPQALVGKSLGSYCHPSDIVSVLRELKEAGSSQNASVDLVFRFRRKNSGYTWIEAHGKLHLEQGKGRKCVILVGRVRHVYKMSWSDLERAGGFGKQEYWSKLTTSGMMLYATPTIGQVLGYRSEDVVGKTLAELSPGEGVAAVMDALAQAAKGVPATARHRLLNMEGVAIDVVTHFYPPRSQTGEESTSAPMFQGSEDSLTVVAQTNSVPSEMAKPAKPSLPSAPSSVARALANFSAHGQRRPSLLVLQPSSGNGSAASSTESSTVSSSSSILSLPSFNMSARGSQDSASTSGTSAGKSTTSFSAITSTYKTLEINSNLSDNIFDELDSVRGTSWQFELHQMRLTNKKLREEKEALVVLQSKKRRREAGQRSDPGKSAKSEIKSCLNCGKTQSAEWRSGPTGPKTLCNACGLRWSKARSQSVSGSKGNEFSPKSLQGSPSCSYPTPDSSGRPSVSPHGTGFSTLSAEEVAKKVKLSAGNELTVPPVPSPSLAPTTAAGHQRPAFNTYHSAYSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MY49</accession>
    <name>A0A2X0MY49_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C005g03564 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C005g03564</name>
        <name evidence="3" type="ORF">BQ5605_C005G03564</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MY49"/>
    <dbReference type="STRING" id="796604.A0A2X0MY49"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050592">
        <property type="entry name" value="GDSL_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45642">
        <property type="entry name" value="GDSL ESTERASE/LIPASE EXL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45642:SF139">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016068031" evidence="2">
        <location>
            <begin position="29"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY77138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="361" mass="38972" checksum="C5743193C8287D7D" modified="2018-09-12" version="1">MGKNKSFWTPFLLTALLCVAMQSPVVEADVVPVRASDAHAHAQYHVQSRAPAPTGYSALVAFGASYVDNAHPRADAYKSSMRNYYPYSSAGGRYSNGPVGVEYMVASGTSPTLKQYGKSAVKLFDYAYGGSVIRNGLGGASSSYPATRDQVAAYITDLKRSRIDIGKGRVLHFFNTGINPVTQIWLKVLDGNMSAASVNTARSNIKSNSAALAEFITSTSQSVTGSVAAADFLIAGIPPLEIVPTFGYQIPSTYTAKQRSQALSILRDLSARFNSDVQRFVSSFKPTSSKVFYYDLAALWRDLTASPSKYGIKVTNKTCYDSTSGAVCMKPTEYIYFDTLHPVTSVHKIWAGKMNALVNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MZG5</accession>
    <name>A0A2X0MZG5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C006g03840</name>
        <name evidence="3" type="ORF">BQ5605_C006G03840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY54105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MZG5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="405"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY54105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="693" mass="77361" checksum="565D54141722E753" modified="2018-09-12" version="1">MVSTFRAFIAHRYRSVTAVHQTLSGLAHWFGPLMGSEWEEVRSNRLVRAAIVGGQKLWRHAPVRAKPLPFDVLSTTLRRARSDPLLDYDRLCFLAMLALAFGACARSGKLTLPDTIRFRDADKLPSCNSVIVSKTGFRVRLPYHKADQRWRGSFLQVVTRATRPHFIDVLSLFLAACDFRFRTMGVGAKLFLTSSGVPPTRNWFITRLHAEFGRKYSGHLLHSGGATHYAILGFLPAKIQRIGCWKSAAWEEYFRTFWEACVKRGLLRNDKEADRCLTKAAVFCTGHKLRHLFAMLLTANDVVTNAAQLWTKHYDNLTQDVEYQLRNQRQQPIITPEHVASWGLLQLSNILQQLDSSLSDHGLPLPTIQFDDEASTNWLIMEESATAAELNKLEGLWRNNFESCNTKQCVVVETVLDLILNSRGKVFFIDAPGGTGKTFLEKMILARICSEGKYALAVASLGIAALVLPKGRTAHSRFKIPIDIFDNSTCNVPKQGQLAELFRMCDLIVWDEAPMQHCRGFQLVDRMLQDVRSSTARFGGLTVVLAGDPKQCLPVIPKSSSTQIVNFVDAPGGTGKTFLEETVLARIRSEGTYTLAVASSGIAALLLPKGSMAHSRFKIPIDIFDDSMCNVPKQEQLAELWDEVPMQHRQSFQLVDRMLQHVRSSTAQFGGLTVVLAGACQSFNSTAQGSMTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MZJ4</accession>
    <name>A0A2X0MZJ4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C008g05235 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C008g05235</name>
        <name evidence="25" type="ORF">BQ5605_C008G05235</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MZJ4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="236"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="579"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="485"/>
            <end position="496"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022695"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SGY79846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1123" mass="122388" checksum="FA315F0544CA7786" modified="2018-09-12" version="1">MVASLTATDRSSSTPSAPCRHCGGPHWNRKCPVKDKKSKASSAPSASLAAAPDISTLVDGPVRGYLTAAMSTLAKPSLILDSGATHHIVNDRACFTNFRKCKPAPLEGITGEAVNSIEGVGSAVVRSFDGSIGQLHHALFVPSAPVSLFSASRANAAGYDINLSRGKATVSVDGSICHTGEITNGLYHMHASLVDVTTLIEQPVNMEVALNEDLKCDTCQAGKITHHPFPTVASNRSAQPLDRVHMDLLAFDGAVSLGGAKYALVIVDDYTRYLWAIPMSHKSDTFAAFKSWLAKVERSSSRKLLAVRSDNGGEFLSNEFSSFLEEQGITRQLSIPDTPQQNGVAERANRSITEGVRSMLHQSGLSHALWAEALATYVYVKNRSPHSANSGVTPHTRWHGSKPSAGHLRVFGCRAWKAATTEARSKLDPRGIPLVFVGYDLESKGYRLFDPATRQVFKSRSVTFFEDEFPARREGITAAHAPVAGDDDDDDDDDDEVVVLPDQHANQAPPDQAELPAALRFDAPGPAWQPPVGSRPRNPPARYGALASLRSTPSAFAFSLGKEVTELVADLEAAGIDTSTANRPLSEPEDPFSLPSSDPTTWNEAMRHPHAAAWKAGAIEEFRSMKDDLKVFSVVELSSVPKGATILPSRHVFRTKRDKAGKMVSLKNRIVAQGCAQGPNSFNNTFSPTAKYTSIRTLIAHSASKGHHIIQADVDKAYLHGVLEEEIYMRVPTGIEGYEGKCLRLHRSIYGLKQAGRVWNDTINATLASLGYRRLACDECIYRHEDAGGDHYIALYVDDLLFFGPDLGEIDRVLDQLDTLYGVKRLGPAEWVLGVQVVRHDDGGISLLQRQYLLDVLARFNMSDCNPCKSPMEANLQLSPEPDTDSADNAIYRSMIGSLMYAVVATRPDLAHSVGYLSRFVGKAGNTHLEAAKRVLRYIKGSLDLGIHYTRTSAPLLGYEGYSDSDWGSDIQTSRSTMGYLFKLAGGAISWSSRLQPRIACSSTEAEYLGLSHAAKEAVFLRSLLTELGLDTSSPLRLLGDNQGAIALTQNPVFHARTKHLRMLEHFVREHVRNGEISVTYIPTHDMVADIFTKPLPRVVFQRHCDAIGLRRISGQEQGGVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N0W8</accession>
    <name>A0A2X0N0W8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C009g05726 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C009g05726</name>
        <name evidence="2" type="ORF">BQ5605_C009G05726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY84910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N0W8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY84910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="124" mass="13562" checksum="22B982F1FC8CD8D6" modified="2018-09-12" version="1">MNWSVEGLGSAIVKIFKQPSFTRTPHPRHHGTLSECHLSSRDITVPPSDATSHPRHHGTLSGCHLSSEPLIRDIMVPSPDANYLPGTLRLPPDANNVRTNHSTYVPARQIEDRYPVAGVVSPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N108</accession>
    <name>A0A2X0N108_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C009g05766 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C009g05766</name>
        <name evidence="2" type="ORF">BQ5605_C009G05766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY85628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N108"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY85628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="321" mass="34194" checksum="46F4F7AD2BEA65F6" modified="2018-09-12" version="1">MEAENLRNAARMSSQRRKLDIAGEVTPISSRSAPAPFMPGHPLTDDDSEWTALIQDLVLSGVEPHYLSTLGCSQLVVDIAAALSGSRLGSQPDSGPSVLQPLSPPISPHGLSTPSAPALNLEPSQAESIHKDKLLSQKAALALRNQARARSFEHELDSLLFPPVDPSAAEEAVPASDPTQKNPTRGVVLSSQEEDSLTSSHERPLDNLTTSPPLAVALGNSTPSGRRTPAQDLFVTAAPAALVIDLSDSEGESEQNAFPTFGGRVRSNPSLGPEHPGPFLAHSTQVENLVRAEQLAQQEVAILRTKLELAQLQRRRQVARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N1P8</accession>
    <name>A0A2X0N1P8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C007g04641 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C007g04641</name>
        <name evidence="3" type="ORF">BQ5605_C007G04641</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY62018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N1P8"/>
    <dbReference type="STRING" id="796604.A0A2X0N1P8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047134">
        <property type="term" value="F:protein-disulfide reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045108">
        <property type="entry name" value="TXNDC17-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010357">
        <property type="entry name" value="TXNDC17_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452">
        <property type="entry name" value="42-9-9 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452:SF0">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06110">
        <property type="entry name" value="TXD17-like_Trx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="13"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY62018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="136" mass="15390" checksum="834A03600005BA08" modified="2018-09-12" version="1">MSLFPPPTQDAASVLASLPRDSKRHMLVFLASHEERGRPWCRDCEAAEPLIVKYLDEKNSTVIWVGSREEWTKPDNVWRQKPWNVQRLPTLIKVEASTSDNVTVQESPSIEDKISNAPHLVEADILEGSKLRGFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N3R3</accession>
    <name>A0A2X0N3R3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C031g10957 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C031g10957</name>
        <name evidence="4" type="ORF">BQ5605_C031G10957</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000068">
        <property type="protein sequence ID" value="SGZ06626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0N3R3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216:SF65">
        <property type="entry name" value="PAXILLIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="513"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="539"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="572"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="640"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="214"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="984"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1175"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1222"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1065"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ06626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1285" mass="138859" checksum="DA6547A20245C8F5" modified="2018-09-12" version="1">MVLSSAVLMPPSRAGSPEQESRPSAVPRSSFSAPRGIAIGTMTHEDGRINDPALVPLPPSPEEAGSSPLLPSNGPFRSRRPSRPGPIVIPPRAILKEPYYVTPSPIPSVSTSSSIWPPPLPASQPRGPRLDVPVSSVPFNPGWTTPFPSVQLEASPPRPKRPARPDEALMFASPLPFPGYKHLLQSPTSDTTAVHGGIRERVDLFTFLHETTHAASPSAAARSPISPISSTNSFDRISPSKRRKPVPKYEASPVRRGPASPRGAPPPTSPARSAKALLARGVPPVSSCVGAGRKRGLGDVDEEDLAAQRLRSAFATDESSKGGKRRATFHGDGIEFEMDPDDTSNTRTSGLVRSRKAHNKTFSWSEKLRQSPWIPRWMARKDTTGRRASREIGFRNVGIAPVLATSDNPGSIQVISHITWKEQAPSTAAKVNRNFVLLPLHNTSQQSGGIRRRSSAVQQEDKEANKGLGEVIVMPSSWENECIYAPERQGELILHPLRINLSALDYRNRLMRLVYLLYSLLIVFPIPTTLFLDYNVIYALVQIALSPSLPTASVLARRNLVGVPTLRSSTPWWIATGLYAGCTTLWILVVCTWLGFVRGYVRHWHRGDVAITKVYQNLTVLSKSVVGNRRSDWFIETCHYYRQAGLSLALLLLFGTTAYGSASSVASSRDSAYFNRDGTLTLFSVGLLMALFPSSSHPFRAASDSSLLDLTRTVSSDSGQPSGWRSRRDRRLRAAILLCLPRSSRSYSSLSGRHTSEFKGGHFHAKSISSPELLQAPSRPAPLGLAPQSVLVAKRDKRAGSTAGKEKENRTMHMDATQMQKMADLDYERRKLARDHAAATLSGQRPMASSPPGVRFPYVLPTLRISEMPFMSREMNMFSDEAVRVPLPETSPEPTTRGVSSPLGLVSPSTRQRRFAARSPAAPELRLDLSAVADESNLLRPPLKSHFSLASDLTGVAKTSSPMTPGGVDFFTGPPATMRLAESEATRPSAGLVPPSPFEMKSPPSLPSSATEPATSPIDVSRTPNNRGVGEGEDWIAAAATTMHVRELQATRNLTDTVIERRSISERLLLEVQRLSEAEEAVRREERRLASLRRIGEVSSAGILQTGLGVTIQSPFIASIRAASSPVQQERSPALPFIPQLGSLEVTPRMSEMASNNDPSQALLPPFRFSYSSPNTTQAGLAIDTDSDPGPATGDDSRSLNPAAALLTTATISEAGVDRYNVGSSVAPRPSPPSLVGRSPYALPRASTSTGTFGIAKSRESRINPDGGVGEPIPEVPETGPSSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N4K4</accession>
    <name>A0A2X0N4K4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C005g03396 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C005g03396</name>
        <name evidence="9" type="ORF">BQ5605_C005G03396</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="7">PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY75033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N4K4"/>
    <dbReference type="STRING" id="796604.A0A2X0N4K4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901991">
        <property type="term" value="P:negative regulation of mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098813">
        <property type="term" value="P:nuclear chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000016">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="525"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="646"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="25"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="553"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00064351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY75033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="666" mass="74798" checksum="416114215DA91EC6" modified="2018-09-12" version="1">MAGTPFATIGGPGSSSSPPPPGAPPLTGLSPAGTPPKAGSAGLLAGAGKLRPAAAAGPKDTIPTSKTPRKQRSSRFHVTERIELERLPGFMRQFALSMTSRDSITTSLTLFPHSSMYPEVPPSERHDLFLQKLHQCSVVFDFNDASTEIEGKQIKSATLSEMLDWISSQRGVITESVYPEVVAMFASNLFRSIPPPVNPTGDAYDPEEDEPVLELAWPHLQIVYEFFLRFVESPDFNTNIAKRFIDQQFVLQLLELFDSEDPRERDFLKTTLHRIYGKFLNLRAFIRRSINNVFFQFIFETERHNGIAELLEILGSIINGFALPLKEEHKTFLTRVLIPLHKVKGLALYHPQLAYCVVQFLEKDSSLTQEVVEGLLKYWPKVNSPKEVMFLNEVEEILDVIEPIEFHRIMVKLFSQLSRCLSSQHFQVAERALYYWNNEYIVNLIGANIQTILPLVFTSLYTNSNGHWNRQIHNLAYNALKLLMEINADVFEQCSAEYKKSRQAEKARQKVREQKWQMLRDDALKNKNDTTPLPASLLSDDLVPQGTYNPMQDLEDEGDGSFGDMEDDGQQMSMRSGGGGYNDDADRSSGRLYQGEDAMESDDGHGDLPNAFPETARKQLPGSNGPQAPHVRRKSVIPVDASILKELASHKPLDDAPLIGSRLPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N6X0</accession>
    <name>A0A2X0N6X0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C009g05418 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C009g05418</name>
        <name evidence="2" type="ORF">BQ5605_C009G05418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY80952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N6X0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY80952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="110" mass="12530" checksum="72E229408B569F68" modified="2018-09-12" version="1">MEKASASDRDLVARGGSNAIVPTSSGQVGSNDHCADVVPLFPHVNTPKKVEAWKMDNATRKSWEAQHKRRIHDDRLMEDIYIVMELKANELDQALADAQPYRRYYRMTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N972</accession>
    <name>A0A2X0N972_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C026g10259 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C026g10259</name>
        <name evidence="2" type="ORF">BQ5605_C026G10259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ28040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N972"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="678"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="375"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ28040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="723" mass="80373" checksum="1B585379C33BA4EB" modified="2018-09-12" version="1">MYGCQQQAKMLRSLHEEMTQFISLRKARGDPHAGGYSNVSSGQALARAFEAGVFDDKQNGFFGLLTDGALVKENREGSFWIWTVTLYNIPIESGRYRRNNTYVLVIAPCATTTTDFDSFAFIILKRFKEAARGIWIFDSIDHTWFLWRGYILFFLAELMGQAKQSGFVMSRGTFPCNNCEMPSATKPNGAGHYIVEDGQATYRGDRCVGRKKAAEEDTGEDDGGDNSDGDGDNDDHDGDGDGNERPQKRQKAVPPSTARKQVNAHRAIRGYYPYNGAPRPRLRTLARYKAQISKAFNLTLSERASKKILEGLKTVGPLLRLCSASYKALVWLGDILENLRAQYRTELVAFLKANPGFKVHGKRISFTRRAKPKENNSGGRNGGARSSQGEQVRLVFVFRAADTDACTPVQQGRFDPEETEMCEEEQGSEGEKERAGTDYDDEYSATARLAEQTYPTLPNARLCWLGDTGANDLSCDLQRLLNSATELCRYDKTFLSTQKHVHPHIKKFAQDLAKLQLSAETNGLNQHDLDNGGAQIGHGKLGLTELAETREDLANWPNWSIWDVVTRLWNCIAAIARDEFAHVRRKGKATGRNGDNGQTLTKVKVGYIFRAAMVPTVQDLMKMVEQALDEHKKETRGEVESELATTSSNVITDDATLQQLASATPDQINKTIATPLAKKHGRGNLPKHAKHASPKTVATQPVSKTLGRLRVPTSDTEYYGQSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N9R4</accession>
    <name>A0A2X0N9R4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C027g10440 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C027g10440</name>
        <name evidence="8" type="ORF">BQ5605_C027G10440</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N9R4"/>
    <dbReference type="STRING" id="796604.A0A2X0N9R4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="22"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="58"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="136"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGZ28758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="817" mass="88151" checksum="FE67A48F857C2F3A" modified="2018-09-12" version="1">MSSRHGSPAPGKAGRLARSRAACEACHRVKQRCDGPSICPCHRCKTWGIECIFPSSAGPVPSQPPPPQAKAPKHTATGTGKIKGKGKAVATPTSVAHPRPIASITPIELTQQLRAMAARLESIEGALARAEVSFPASSSSHSHHPSYHRPWHSHSGQTVSDETPLSGPYAHEHHQHQPNTSNPVEATGEAIEAMAVEGLVGLSDSHQQSRSRATLNGIGNASAANPDVYFVHLHPWVLSLSSTLDRNPLTVRNRSPLLFHSILLISIYYRERTTENLALYQAISAIIDSILAPNILCPQPDQLSSDFIRSIHLLTLYKPLPIATFHARGIKDLTAIEHASKMNVRASWLLRLIASRVAMFIGLPSITTTFARAFANQHEAPIPQSIINEQRLYFGCVFHEAHGALQSGKPSNFVPQDALKSTRLFASLKNQPEDVRLAASVELAATAASVLATRKEGDFFDREDLHRFEDEMSQWTEYWQPILAANEQRDRLAWTAAIPYQAFIRVVVHGYSFARWKAHKTELQASLQPAPLLTEHEYESLEAAVEASAAILLAVSVEGKRTVPGKGIETSWENVKGSLTVDPNVADKVRWASDSLTCVLFSYPLIFLAKLANEGLLLSSFSVLAASTQPIPLAPLSPSDKLCLLLQLGANLLQAIAPHPSHPAIKQAAFLRKIREAGISGRKQTLSVPTSPKLSATTSVPVPMTTNLSLSEHSTLTQPPSNLLPLSNGSYHDFLSTTWNPSPIGSPRHVDHVIEDPFGALLSGVEPGMMFASGQRDLFGFETGLTSADWGGLDAGAAAAGTQNGGGGNGRMFNGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NC74</accession>
    <name>A0A2X0NC74_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C040g11839 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">BQ5605_C064g12782 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C040g11839</name>
        <name evidence="5" type="synonym">BQ5605_C064g12782</name>
        <name evidence="4" type="ORF">BQ5605_C040G11839</name>
        <name evidence="5" type="ORF">BQ5605_C064G12782</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000118">
        <property type="protein sequence ID" value="SGZ32264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000132">
        <property type="protein sequence ID" value="SGZ35133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NC74"/>
    <dbReference type="STRING" id="796604.A0A2X0NC74"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="212"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ32264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGZ35133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="299" mass="32687" checksum="26F91642904506CC" modified="2018-09-12" version="1">MLVHLHDLTNPTVPKSLPTQGAILDVTWSPDSNTKIYYAGLAGQVRSVDFETGLDQLVCTHQQPVKCVEYSDQLNAVISASWDKTLRITSPTASIVLPIADKAYCLALSPTKLVIAMAGRRVWIYELNTLKEALLKGTNGEQVEVWQKRESSLKFMTRALKCMPNDEGYVTTSIEGRVAVEFFDPSPNVQAKKYAFKCHRQVIDGVDTVYPVQGLAFNSVHGTFVTGGGDGTVSIWDPVAKKRLRQWPKFRAGVIGCEFSSDGRKLAVGWSSDDLVDVGGVHGVSVREVGEDAKGKGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NFK1</accession>
    <name>A0A2X0NFK1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">BQ5605_C026g10191 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C026g10191</name>
        <name evidence="14" type="ORF">BQ5605_C026G10191</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ27798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000007">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="12">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="13">
        <location>
            <begin position="545"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="11">
        <location>
            <begin position="857"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="13">
        <location>
            <begin position="1418"/>
            <end position="1587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1663"/>
            <end position="1746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1764"/>
            <end position="1784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1673"/>
            <end position="1683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1684"/>
            <end position="1696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1697"/>
            <end position="1706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGZ27798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1784" mass="198867" checksum="D70AFD6EA7FA0BEE" modified="2018-09-12" version="1">MIRSNYARQTAGQESCACGGNLLEKGCDVDPTIAPRWVNDYRELNKHTIKDRTPLPLPDDILSTCSNAQFWAKIDMTNSFFQTKMAEEDIHKTAVSTPWGLYEWTVMPMGLCNAPATHQRRVNEALQGLLGTICFVYLDDITIFADTLEEHEARVRQVLDALRRAKLYCSPTKTNLATAECLFLGHIINRAGVHADPKKIQHIEDWSLPKTVKELRGFLGLVQYLCKFIPGLAEHTAALTPLTRQGLSSIATLWIPNEVRHFKAIKAIVTSLDCLRPPDHSANAAPFWVMTDASNQGIGGVLLQGQEWKVARPIAYWSRQYIPAERNYPTHEQELLAIVEALKEWRIDLLGGHFHILTDHSTLEHFQTQRTVLSRRQARWLDTLAEFDYDLRYLPGEDNIIADAMSRYSFTNPLPTLVAGVSHVKLSDAVKQQILDAYETDPFCQQAMSNIGSVTSDFKIVDALLYLRGRLIIPSLAPLRESILHDAHDAQGHLGDMKTYQTVQQAYFWPNMSRDVKHYVQQCDSCQRTKACTTRIAGKLHSLPVPTRPMADIAINFVGPLPANKGFDRVLTITDRLSGYVRLLPARKADTAAEVAARFHEGWHRLFGLPQSIVSDRDKLFTSKFWTALHKRLNIKLQLSSVFHPETDGCSEKTNKTAFQILRALVNKEQSNWAECLAVCEYAINSSLNVATGETPFELVLGYTPSLAPLAHVDGDDDLPSVEELLALRFQACEDARDQLAISKVRQAAQSNKKRQDEPSWAVGDLVLLDSSDRRKRLHTRKRRAAKLMDRFDGPYCIVKAQPEILSYTLQLNGDDAAVPFFHTGKLKTYHKNNTALFPNHEPARLGPVDVGGEPEYIMEDIVDERIRAGKQQYLVSWLLWPSDSNSWEPAEALEDTEALDRWERWNEEESGGSGSAHSDASPRLTSVQVADKVAEYREQAIRRNNLACKYIANSISEEQMSHLIHLTSAYEMWDTLRGLHSHGRPSRTMDLLNTLAQPYSGDIPFKEFINKVKIAMADFQNLGAPLPHWLFAGMLVRSLPAHRTMDLLNTLAQPYSGDIPFKEFVNKVKIAMTDFQNLGAPLPHWLFAGMLVRSLPAQYDSIVGNLASDIDIHMDWNMFYPKLLMNVEMADSRNKQKESLSARIVDNTSLVARISTTAQKDYSKSDCSRCKALGHERGWRLCPSRNKDASAPASSDSNSNVAAIGVDESALMTYTFPYSRTMPRFPWIIDSGAKVHCVGDKSVLSDVVSEPLKISVADQSQIKSPGHGSVTFLTSYGARITIKRVYYMPGAQCGFISIDRLLESMTYAVGPQSNLIFSIRGKLILRSLPGRGFVMDAAPVQPIMSSSPPSMVGANRLTGTCTLMEAHLKLGHQSPAAIVLAVKSGAITGITLKDEKVTPCFSCIQAKSKRSPFSNKSTEAPHALYRVFIDLGFVEHPNRNGDTIYLAIVDQYSTAKWTIVLKDKRAETIIEAWSKFQAESERQTGQKIKRVRSDDGREFNNSLFRALLEKQGTIVEFTAPYTPEQNGQVERLNGSLMGLVRSMLLDSGLPMRFWSDALAVATFVLNHRPHPRIQGKTAIEVLLGKKPSLAHLQPFGSTAFVHVPKERRSKLAPRSIQGVFIGYSGEYNYRVWVQSSKQVYVSHHVTFLETPSVVTLSQDCADASDPVHHSQPPHPPHPPPDVLPSTPTSPVVDPTLPDPQPPPVVPIGVGQQGGYLAVVPRKDDDNDDNNGPDNYHDAEEPLDGEAEVALAPREGYAIVCTGPNPGQFENVDPSNILPAGSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NHX4</accession>
    <name>A0A2X0NHX4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C045g12200 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C045g12200</name>
        <name evidence="3" type="ORF">BQ5605_C045G12200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000115">
        <property type="protein sequence ID" value="SGZ31543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NHX4"/>
    <dbReference type="STRING" id="796604.A0A2X0NHX4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="2">
        <location>
            <begin position="76"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ31543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="124" mass="14546" checksum="74B270D4EB39C174" modified="2018-09-12" version="1">MFEFEESLSWFLFEISVLVLGSGFWFGFISSFAAAELVCPGRSLTSGWDGVVHPSCRFQKKSERHEIALEPHWFRVQTERIKRSGKQQYLVSWLSWPSDSNSWEPAEALEDTEALDRWERRNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NIJ1</accession>
    <name>A0A2X0NIJ1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="10">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C040g11901</name>
        <name evidence="11" type="ORF">BQ5605_C040G11901</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the tannase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="10"/>
    <dbReference type="EMBL" id="FQNC01000118">
        <property type="protein sequence ID" value="SGZ32675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NIJ1"/>
    <dbReference type="STRING" id="796604.A0A2X0NIJ1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF15">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015800606" description="Carboxylic ester hydrolase" evidence="10">
        <location>
            <begin position="27"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGZ32675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="576" mass="61896" checksum="9E4517520EABEBE9" modified="2018-09-12" version="1">MVGFGTSPSFLTAAAVVALCLTGVNARTRRHGRSAHVGDADFSTRCANMAIVQMTDMTINVTEYHGANTPVSPAGPGSAAFCRFGAEIKTSSQSKVYFEVWMPDDWSRRFAMVGNGGDAGSVNYPDMSVPLTKYHFAVASTNTGHNGAPFDGTFAISNPQSQIDFGHRAVHLTATYSKKLIRTYYGGDGAKYNYWIGCSAGGRQGLKEIQLNADTFDGSLIGAAPHWWSHYNGYVYRSNAFVNKVGSTGFLTAANYKTIGIEVLEQCDVLGQDKLKDGIITDPVSYLASSCLRKSKPLSSFLSFLLSQQTKCSPKLEGLLCSAKGANKATCLSQAQIETMYTIWADWKSSTGLATGPGGTNYFPGVLAGADGPPGVPYGPSPDYFTYQVLNKTSPQPLTVNSEAEFEKLLKTADDTDPGQTNAINPDISEFLSRGKLMTYVGLADSLVPARLSLLYHERVNAKLGNVDESYRLFAIPGMSHCGGGNSAFNLGQASQSDISLGGNLQSANFTAKYDMILALIAWVEKNQAPDSLVGVNYVNGDKRQGVAFERLMCPWPQLGYYRDGDTTKASSFACK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NQY9</accession>
    <name>A0A2X0NQY9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C015g07961 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C015g07961</name>
        <name evidence="2" type="ORF">BQ5605_C015G07961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY18041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NQY9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="644"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY18041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="721" mass="78472" checksum="5694D9E02BFAFAC5" modified="2018-09-12" version="1">MVKRNSAQRHYLIGNGLAPDTQQASTSRLGAYSIPHPRSTSSTLTPMPSSDIVGLGVAGGAVVADAALQLLAGGATSSHSRVAAKRRRTNGQAGQGSHRFSRHPSDSLHQDDDGQDDGASFSPSSSLSLRSLATTHALKSSHVQSLAHLPADILLRIADLLQPILSPFRADGDTDGLTVSGDGDGGPSLSSQWIDPGTDVINLRSTCRAIYLAVEPLRGTVSGVRLQQGEHPGGVRVLTNFPLGKGAIDPSGDGSELLIARTRHLWIHSTLPRNATDSSIFAASTICALIEGMPRLRTFALVQATEDEVVFGSPYTALPLHRNIFYSLSRLERLHSLYFCGVKLQARAPVFPHVTTLVLNACHDCPLELISTCPKLEIVKAWRDFASRAQLEMAGKWWPEQRWMTVKHAELRGFSGVTGSAFRLSWLRNLMVRRVKFPLPVCGLTSYTSLPTTPTQTLRALSTPPVIPLISLRLCEAYDYTDLCHLILPAIAHLPHLTSFTCMVWKDRNFSPTLLGRIAGDLPNLVHLGLLLENEGTNWWPGDMGNYGHELMRFKKLETFTWNFTAYVGLDWAATRETSLSVIQSLLCHVGPKFKSLHWLQQSEYVLRSSRTSKWVWSDDVIERRLLEEGGILDDVDAVGHGGNSRDGKENRVDDGTAGVGVGVPKRKRGIGGTARKKLFDVASKGIVGGGGGRRRAPSQWALGIDWEQDEEGSSDADPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NUS6</accession>
    <name>A0A2X0NUS6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C018g08771 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C018g08771</name>
        <name evidence="1" type="ORF">BQ5605_C018G08771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY26752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NUS6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY26752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="117" mass="13037" checksum="D9709AE2C9374CC0" modified="2018-09-12" version="1">MALCQLYNNVLSFTSLTAHWDQTHLGTLGPPVFRMFGCLYHRLGALIPAVNQRPAFVQTWLIDPAKATNTRLGPDGADSCMQQSTLSRISASESRQFNMLERSVNYCNDTVNTTDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NV82</accession>
    <name>A0A2X0NV82_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]</fullName>
            <ecNumber evidence="10">1.5.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Saccharopine reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BQ5605_C002g01004</name>
        <name evidence="16" type="ORF">BQ5605_C002G01004</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-saccharopine + NADP(+) + H2O = (S)-2-amino-6-oxohexanoate + L-glutamate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57951"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 14">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.10" evidence="10"/>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY29041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NV82"/>
    <dbReference type="STRING" id="796604.A0A2X0NV82"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004755">
        <property type="term" value="F:saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000008">
        <property type="entry name" value="Alpha-aminoadipic semialdehyde synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000072">
        <property type="entry name" value="Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1870.10:FF:000002">
        <property type="entry name" value="Saccharopine dehydrogenase Lys9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.140.10:FF:000001">
        <property type="entry name" value="SPE3p Spermidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000013">
        <property type="entry name" value="Spermidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1870.10">
        <property type="entry name" value="Domain 3, Saccharopine reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.140.10">
        <property type="entry name" value="Spermidine synthase, tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030373">
        <property type="entry name" value="PABS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035246">
        <property type="entry name" value="Spermidine_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037163">
        <property type="entry name" value="Spermidine_synt_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002010">
        <property type="entry name" value="PRK00811.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00417">
        <property type="entry name" value="speE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF22">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17284">
        <property type="entry name" value="Spermine_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01330">
        <property type="entry name" value="PABS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="15">
        <location>
            <begin position="12"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00066976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00083134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SGY29041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="781" mass="85822" checksum="3AC56880AB776B63" modified="2018-09-12" version="1">MSAELSHKTIVDGWFREISDEQWPGQAMTLRVKKILHVEQSLYQDVLVFESTDHGNVLVLDGAIQCVERDEFSYQEMIAHLPLASHPNPQNVLVIGGGDGGVLREVLKHPSVTSATLCDIDEAVPRVSKKYLPHMAAGFNDPRVTVHIGDGFKWLDTHKGEFDVIITDSSDPVGPANSLFQKPYFQLLKEALKPGGSISTQGECIWLHLPLIDDLMSMTRTLFPVAEFAYTSIPTYPSGTIGFVVCTLDENRDLRTPLRDIENTRYWSKAVHKQAFTLPTFAQKVADKSKTKKAVTTGSSSAKSSSPKKVLLLGSGFVAAPAAEYILRRPENSLTIACRNVETAKALASELSREAQAISVDVADEASLDAAVKEHDLVISLIPYTYHTAVIKSAIKFKKNVVTTSYVSDAMKALEAEAIEAGIVVMNEIGVDPGVDHVWAIDMFDRVKQDGGKIKSFISYCGGLPAPESADNPLGYKFSWSSRGVLLALLNSARLYSKGELVEVDGKELMKHAQPYFISPAFAFVAYPNRDSTSFREKYDIPDAETVIRGTLRYQGFPAFIKALVDIKFLNESPVEYLAKGSTPLAWNEVTAKALGTSDKSEKALVEKIKSLTTFPNQAEEERIVSGLRWIGLFGEEKVTPRDNLLDTLCATLEAKMQYQKGERDMVMLQHKFEIENKDGSRETRTSTLLDFGAPVGSGGYSSMAKLVGVPCGVATQLVLDGVINKPGILAPCKSHSPCKDMKCETDLCGVFVWIADTRDIVDPLLVELRKEGIDMVEKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NWG1</accession>
    <name>A0A2X0NWG1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C015g07935 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C015g07935</name>
        <name evidence="4" type="ORF">BQ5605_C015G07935</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NWG1"/>
    <dbReference type="STRING" id="796604.A0A2X0NWG1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02022">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00152">
        <property type="entry name" value="dephospho-CoA kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="32"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="288"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY17948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="322" mass="36253" checksum="FFEBB3E40DA63A9F" modified="2018-09-12" version="1">MLGHRWSNGWDCLGYVTHGPSACRYRRHRHRHRHRHRHRHRHPALHSSHPTVSSPTNAPVPSHSPGKSTVSSILKSHSLPLIDLDVLAREVVLPGTSSLSSLVSHFGPQILLPDRTLDRDKLGSIVFGNEKERKVLNGILHPAIRKLLVKKLVGHWLKGQKVVVVDAPLLIEAGLWKFCGAIVVVYCSESLQLQRLQSRNSLTSDQARSRLSSQLALSKKLLYADYVLDNSGPLADLTPQVERVIKKLDARAGWSWRLNWWIPPLGLVRGLWRVFWRLYIQGVGKERRAGHKTKGERSPHGGGEEIEMLDRKGKGNRGGSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NZ05</accession>
    <name>A0A2X0NZ05_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g02506 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C003g02506</name>
        <name evidence="1" type="ORF">BQ5605_C003G02506</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY41395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NZ05"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY41395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="141" mass="16149" checksum="BDF213E579B73E03" modified="2018-09-12" version="1">MNGIWAKRADNSARRLWSALSPTPHPVFVDFVCPVVSRSERRLVELRVLFFHSIWKLCRRRRFSSDLLEPITETEFEGLRASIQESKGRLVSLVNESYTTGFCQCCGPEARLWWMYQHTVVSAAPACGVGVPIRSHVQALW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NZH6</accession>
    <name>A0A2X0NZH6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">BQ5605_C019g08912 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BQ5605_C019g08912</name>
        <name evidence="16" type="ORF">BQ5605_C019G08912</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY23189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NZH6"/>
    <dbReference type="STRING" id="796604.A0A2X0NZH6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16449">
        <property type="entry name" value="RING-HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014905">
        <property type="entry name" value="HIRAN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF17">
        <property type="entry name" value="HELICASE-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08797">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00910">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="429"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="800"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="880"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="53"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="540"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SGY23189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1065" mass="118810" checksum="5A882C90369A1451" modified="2018-09-12" version="1">MVAAMSSSSPTRSSSPDRMKIDLNNAAGEEDEVLVVASSSKFKIEDQLVLKAKPTNKRVLDLTQKSSPSNKGKELASHDGNDDDVHQNDDNDDDEERADPVDANELGEDEKHIGRVEDGLDEDEDIVIGQIPLANVNGTKHYGGVKTLKPGMKLEFKRDRTNLVDPQNAIAVSHARRGAKIGMVAKGLAARLAPLLDENLIELEGVAGEVDPKGTHMITSITCCISIWGKRSVGRDPRLDWLFPSRAKRATMLARATKSVLANHNNQSNDLKMSRGGSMASSNGGPMMSDQEKVSNFCAGSELTLQVILLILIALSSSQLKQEVLMMHALMIEKDRRAVGGDPLSELFKEGGLDPSRLPMHPCPPGKKDKTMRTDLMPFQKQGLAWMIRMEHPRLPRKVDDPPVQLWQRKIDPNGEPFFYNVATELMQREKPLLKRGGVLADEMGLGKTLTTIALITTDDTGDGVLDQPEDPDDRFDDMTLIVCPLSVASNWTSQLHTHVGSKRLKWHLYHGDGRSLTKKQLRNFDVVIATYQTLAAEISDPNSSRATTAEADEENGGPDKKKAKVPAKKHDTLHQIKWRRVVLDEGHVIKNPKAKMTIACTTLIAERRWVLTGTPIVNSSDDLGAIMSFLRMCKPLDNREEWLKYVGDGKNATESSAKILRAIVASTTLCRTKDMKDSTGKLLVTLPKILFYELRVELDPDTRALYDEIQAQLKDIVRTYMKKDTINSHYQDVLVMLLRLRQLACDPSLCPESFLEAVRERQLARSLEKSIAFDRKLDRAELSELQMELRQQLAHGGTCLICGEMPNDPRLTLCKHLYCSPCIEGDERRRRDCPMCRTTIDYDQLIEMDGAVSETASLVDEAEVLERQKKEGARATSPKIARLITLLRADPTAKSLVFSQWTTHLNCLEAALEQAGITSCRFDGSMTQAKREDMIKAFSKAPPAASIRLKKGEKPPPTVMLISLKAGALGLNLTCANQVFLMDPWWQASIETQAIDRCYRIGQTREVKVFQLIAENTVEDRVLEIQNRKNERISEAFSGNKDGFKARQKVQVRKLDDILHVLDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NZR7</accession>
    <name>A0A2X0NZR7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C019g09032 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C019g09032</name>
        <name evidence="5" type="ORF">BQ5605_C019G09032</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY24293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NZR7"/>
    <dbReference type="STRING" id="796604.A0A2X0NZR7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF90">
        <property type="entry name" value="CENTROMERE DNA-BINDING PROTEIN COMPLEX CBF3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="100"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="795"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="795"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="816"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY24293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="928" mass="103018" checksum="FAA2D5DC95D45985" modified="2018-09-12" version="1">MSSNASPASTTAGERASGRGAKRVSAAAALVKAREQTIDTNTNTSDDSDDDDDDDDGHDHDNSAGPSAQATHNSIGNGGTGVGAKKPDRKKRKRNRQALSCSECQRRKIKCDRHIPCEACIKRGEADTCQWEEKKIVVPPQPFALASEHDALKARVAELEAYIYKRRSSPKPNVPLPTPAPLVAMQVSAVEPPRGPHHPVVAGSLTSKRDAATEDAALVLTSTSKQSLLIVAFVLIFELDVTSTAGFRAPEAIIRPGHAIPLLLSRATESLLVPLAEGARRTMLDLIWRTVPSSKHLVDWLVHNYFANYDWSWHLHHIPLFQAEYESFQSLCQQGRRDEIDPLWLAVFFQTLCLSVHFLEEPVTSPTVTISKQDLMTLPQKYFEAAEAMLQVAEWKVIPRYRTLQTISLFSPYLLWMGNPSSVLDSTCYLPSVSLTCVWSDRTGERLRTYVQAGVRMARSLGLHKLGEDPTTMPVEDPGLPSGAHTLRREMALRLLRNLLFVEWVSTNKLPPEMTPNLIDSALPGNFEDVDLLREGIVQPRPYYDATDVSYDLIKWRIALVQRAFNDIVHGEGPLSYSSVLDLDRSYREIIDSFPTRYLPSYVAPFGEPLTTLWSRSMALQTINSRLVRLHRPFMYRGYTDFKYRISTDNAIVGARTVLMCQQSLDRAPPVKGAFQPLAVQMAVTVLFLAIWQDFTRTVVEGEDYRFIQGVVGYFERLRTSREASIRHVATQTHSVITRLSQEVEQRRSAAEFRVAAGGHWDDLGTVESFGQLLERLGAPKEMIAAMGLSNPRDAADHIFSDRPHDWSRNVKLEPGTSSRGDRTSSTNNTPMGSTTPISVNAVATSSAPASSLLVQHKNGTGVNSWDGEVPSAILSDSANEQLATSWSPTDLALNFDLQGLMVPEYADVAFGFDAFTTQDLFPLDNYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NZX1</accession>
    <name>A0A2X0NZX1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C019g08873 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C019g08873</name>
        <name evidence="2" type="ORF">BQ5605_C019G08873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY22928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NZX1"/>
    <dbReference type="STRING" id="796604.A0A2X0NZX1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="632"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY22928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="661" mass="74194" checksum="0DA84D3D5E5A6E8C" modified="2018-09-12" version="1">MSNLECSAGASTSSPTKRPKPSLGTLPPELKAIIVAMVHEVDCEAALADEEDDDDDDDDDPVEEVVVEEEKENVKQVSKNNTSSKGKSVEMPPKAIIPERKPVDDDDDDDDDYDEDDADDDDDDDSSFDGRYARVPVHRTMCQLSLVNREFAALAQPFIWSAVHMDTKTLPDIYYFYTTIIPRHGQHIEGLSFSINEFCTQGPDDEGDDTNWEDTELDDDDDDDDDDELEADHHDPSTDAKVVHRKRNAVPAKKKSSMPADYIKVLDALAAAGICPRSKDTLYWHQYATARALLFEEILRKLPKLTTLDFDLLAHFPRNDGPSDPRRVPVVDSFPGSLLEEGGVGPQIIDLTLYGDSNSMIPFNELEVMLGAFPNLKRLHLGFEPTSEDDEDDGPECVYKALAELKYLESFTLDNAYWLDTRFANHEFKGPLKLIALSDATEITWDALRRAVEKLSATLEVLDLDSFALEFADLLDSAQTEGDAEGGFGPRERLLRPWKLPKLDTLVLETDHDPAVLTVFNDCPIKQLELGMCELFGYSTVEDFITMHESTLKSLIVIQDSFLTPAQMESLELLAFHKGIDLVVRDPDSDSEDEDDTYRQEDLDAQLYYAERGHDEDDLYRYQGFDHWGYGDDLDGDDSEDGYDSEDEFGPGGSSRFALVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P0H3</accession>
    <name>A0A2X0P0H3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C018g08716 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C018g08716</name>
        <name evidence="2" type="ORF">BQ5605_C018G08716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY26282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P0H3"/>
    <dbReference type="STRING" id="796604.A0A2X0P0H3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039730">
        <property type="entry name" value="Jlp2/Ccd25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13049:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13049">
        <property type="entry name" value="DUF814-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY26282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="239" mass="28076" checksum="60D52D661447ED9C" modified="2018-09-12" version="1">MVYFYNCTAFGEGKTVTIYAGKDKNETLIDCSQTKILYVMRYRRPLTGLLLPADVWVHVDKLSSPHIYIRLPTWIPSQGNKKDNITVIYTPASNLLKTVEMDVGTVVVIVFFVEKAKTLYHRTLTSVSFKNDRLVRRVYVAEHINAIVNRLNKTRVERVVDHEAEKIEREQKEAKERRLESNERRNRELELSRLRKAESESRDYSRLHETKAALSYEEEEAEWNSRQKDGEFDPDEDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P1F3</accession>
    <name>A0A2X0P1F3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA (guanine(37)-N1)-methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA methyltransferase 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C002g01259</name>
        <name evidence="10" type="synonym">TRM5</name>
        <name evidence="13" type="ORF">BQ5605_C002G01259</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="10">Predominantly in the mitochondria and in the nucleus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRM5 / TYW2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="10"/>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY31762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P1F3"/>
    <dbReference type="STRING" id="796604.A0A2X0P1F3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070901">
        <property type="term" value="P:mitochondrial tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.110:FF:000001">
        <property type="entry name" value="tRNA (guanine(37)-N1)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.110">
        <property type="entry name" value="Met-10+ protein-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03152">
        <property type="entry name" value="TRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056743">
        <property type="entry name" value="TRM5-TYW2-like_MTfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056744">
        <property type="entry name" value="TRM5/TYW2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025792">
        <property type="entry name" value="tRNA_Gua_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245:SF36">
        <property type="entry name" value="TRNA (GUANINE(37)-N1)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245">
        <property type="entry name" value="TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="TRM5-TYW2_MTfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25133">
        <property type="entry name" value="TYW2_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="12">
        <location>
            <begin position="202"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="394"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="408"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="329"/>
            <end position="330"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="366"/>
            <end position="367"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGY31762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="541" mass="60298" checksum="FBB8087CE94F52DC" modified="2018-09-12" version="1">MPPTLHRFLLRTMSSCSISQGTTRPSKSTGMGTGTGTGSRFNREVAPPIHRGMTELDRSRFSTRLRFVAAKIPANETGRFRDGVAKSYVIRSTRRLSLSGKARTDQVSSRSLTCGALNSSLLRIPRLPAVVNDPDTQTHRRVILQLPREEITKDSPLQRVLDELGGSWVDHDITLDYEYWSADQILQSILPEDLLDESPTSFTQVGHIAHLNLRDEYLPHRHLIGQIILDKNKAVRTVVNKLDTIDNEFRNFAMEVLAGPAEFVVTTSESGCTFTFDFSQVYWNSRLQMEHLRLVESFDPKDVLVDAFAGVGPFAIPAGKKGCGVSASDLNPASASALKENATANKASPARFCLKVDHIVRTGNADGRDWIRQSVLNIWNTPFPAYTPPLSAKARGKLARRANDPKASPSTTSSPQKPTSVAPMDLGPPRRLVDHFVMNLPELAITMLDAYKGLYHELYKLPGARQAIEKRGEEGLPMVHCYCFTKNMDDQEGDILARASQALGMPVTKEARDYKLRFVRDVAPKKEMYCLEFRLSKEMVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P420</accession>
    <name>A0A2X0P420_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C004g02671 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C004g02671</name>
        <name evidence="1" type="ORF">BQ5605_C004G02671</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY66418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P420"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY66418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="71" mass="8023" checksum="6D5C553269D06542" modified="2018-09-12" version="1">MYLKPLFLTRLRPSGPLVVDVPAYCCVCNRPDLIARVFEAKSGNKRHAGCFGNECKMNGFCFFAVFRIVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P4K1</accession>
    <name>A0A2X0P4K1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g02560 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g02560</name>
        <name evidence="2" type="ORF">BQ5605_C003G02560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY41799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P4K1"/>
    <dbReference type="STRING" id="796604.A0A2X0P4K1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY41799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="412" mass="45880" checksum="32B779D0B8D07091" modified="2018-09-12" version="1">MQLNLQSGPQYLGPKGHNIGTEKALDEVIKGVVNMFIPSRAESPFKSRFSLLVFSSRVAPDREETAETTADVVLLTRAVVAHDPTLPNVWAFPSHPVPQAEKPDADADLDTNVNFNANENGSGQHQNDEAEAEDAEDNGCDQYDEDVAKVDLLWAKRYFTHVVPMCETKAEKSSGPWTVNPIACSRIGVARGADNRLNKWPSALELPALVSSTAATCVKERERLARFTSPRPPRRTCRASRFFTQVAAVSETKAAKKSRAKDVSFGRLSALLATPIREHAIGFTLQYNLLKNGHQREWRAADLLYHLIKHNFRWGATTISDVELEKFVFRRLGECGRATLMYEISAGEGTSCKTRAMTITSRRLGPLVLGVFCTDYRTLPAFLPSDESFKGIVPWAEEAALWRERELVQILH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P7N7</accession>
    <name>A0A2X0P7N7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C008g05064 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C008g05064</name>
        <name evidence="1" type="ORF">BQ5605_C008G05064</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P7N7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY79171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="205" mass="21551" checksum="6730D2C23B3FA622" modified="2018-09-12" version="1">MVLYMHENITARNFGDLGPSINDSAVALMLEAIAEVGSSRAGGEVDEARPVVDEALAGPRPPIGGLLEALAAWAALVARSIRARYAAMMNWPGCSFTIEESNAINSRRTKGDPSVELLSVAIATPNSMSFASSGDRPHAGPVAAIERPNFLFGSLDPVVPNNVPNAYSTDALTSGIGSLFNKLQKSSCTRVRTPRPLASSKSSQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P8N5</accession>
    <name>A0A2X0P8N5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C009g05515 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C009g05515</name>
        <name evidence="2" type="ORF">BQ5605_C009G05515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY81682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P8N5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY81682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="178" mass="18403" checksum="C6B840EC305FCC45" modified="2018-09-12" version="1">MTLSPHWPGPHPRSHESAGGGAAATTTTATSSATTTGKRMMASMSHHAHRPHDASTDPAHSPNPSLGTKLSYEIRLEGKGVVTGSLYDPVRYEANPRRALLSAPSAGGVVGSSATPHARAPAIGSTTATKRRAHSPARQEHQLPGKRNCIVAATAAHGRCESSCTCPGVVPSRVRPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P8T9</accession>
    <name>A0A2X0P8T9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C009g05575 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C009g05575</name>
        <name evidence="9" type="ORF">BQ5605_C009G05575</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SOS response-associated peptidase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY82523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P8T9"/>
    <dbReference type="STRING" id="796604.A0A2X0P8T9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106300">
        <property type="term" value="P:protein-DNA covalent cross-linking repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1680.10">
        <property type="entry name" value="SOS response associated peptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003738">
        <property type="entry name" value="SRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036590">
        <property type="entry name" value="SRAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604:SF0">
        <property type="entry name" value="ABASIC SITE PROCESSING PROTEIN HMCES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604">
        <property type="entry name" value="DC12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02586">
        <property type="entry name" value="SRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143081">
        <property type="entry name" value="BB1717-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="53"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="377"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY82523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="453" mass="49680" checksum="E220537BBCE7D962" modified="2018-09-12" version="1">MLSPEPPSLHADFATGPRPPPPAPPPILLPGPARTSVLFCSYDADDLQQELVRQYFIPQRPRGRRRGGAPPRGDDDDNDDDGDDAGGNDEAQEDQEQQLDQGECSRVHERITDGQQEGTIASGQASGSGFLEERSSSTARASGSSGVIEWASDTAKKRYRPRYNVPPKSNSAVLIRDKTMSARSGAEHYSLDLLQWGLIPAWSKEPPEGGPLHTINCTYENLSQGTPLWRSVRDSKRCIVVADGFYEWLTKGKDKLPHFIKPADGRLLCMAGLYDHATFGDSFDPVTTFTIITVPANQQMSTLHHRMPAILQNPEEIRLWLSEEKWTKPIENLIRPYERELTIYQVPKGVGKVGNESPTFIEPIKGAPGTLETMFAKQNSQGSPNMPKSASASSASPKWKSSSPATLKKEPATHKRKKGSFIEVIDLLDDSDGAAEGESNADAKPAKKLREAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P8V0</accession>
    <name>A0A2X0P8V0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g04201 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g04201</name>
        <name evidence="1" type="ORF">BQ5605_C006G04201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY56956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P8V0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY56956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="126" mass="14001" checksum="A4864FA52839078D" modified="2018-09-12" version="1">MTHCSLASTVVGLPILQSSTEKPDAKSLEDQLGQIRRDLQALRAMLESVVKFIDTPSIDHLKSRLPPFVLVWTNLHLRPSRMCDLVEPVRYPCVCHMARPYRAIGRSLSLPYGYTTAAVGLSNPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P9I4</accession>
    <name>A0A2X0P9I4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C007g04472 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C007g04472</name>
        <name evidence="2" type="ORF">BQ5605_C007G04472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY60718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P9I4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY60718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="286" mass="31417" checksum="DB295E2DE8116305" modified="2018-09-12" version="1">MVTSPAPTRSHYLPTPLPPLALLPPFPINAHANRRSSTSTTRSNRTTSASTSKSRSPTPDLLPRSTDVMMTCIDGRARLLFRHTTVAKGAIGPVVRLDSAETTTARELDEPHGPINRFSWSSSSSRTTTEPSTRSSSRSRSTTASGDDENDQITPRKRTDLHPNETGLDLSSDPIYFSPSPSPSPQSSRIGKKARVARSISESLLGREEAKSFHLDSRKSKIGNPFPSTNKTLSDLSFLLYHSDRLPEAWLTMLDVLVEEGKMHLQAAEREEEKRGTEDGLGIRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PBA0</accession>
    <name>A0A2X0PBA0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C004g02936 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C004g02936</name>
        <name evidence="2" type="ORF">BQ5605_C004G02936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY68982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PBA0"/>
    <dbReference type="STRING" id="796604.A0A2X0PBA0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016073888" evidence="1">
        <location>
            <begin position="19"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY68982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="175" mass="18698" checksum="F191E439AD4F1A46" modified="2018-09-12" version="1">MSWTSLSALSLFLLSTPSDEPFKLQQTDYLRHVTDAPSSRPPPHSDDDVTSLHRFALRRSAPTTLRTVFRTQQRNFVGSAYLSKTLTDSVKDAAAKVNRVVSDAALGAVEGGEKATDAVKDSTSPITDTLKSAFGNAQAEAKKGGSEIEKNASKAYADVKSGLDKAAAEAEKKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PBN6</accession>
    <name>A0A2X0PBN6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C004g03076 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C004g03076</name>
        <name evidence="3" type="ORF">BQ5605_C004G03076</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY69898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PBN6"/>
    <dbReference type="STRING" id="796604.A0A2X0PBN6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016171060" evidence="2">
        <location>
            <begin position="23"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY69898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="431" mass="47169" checksum="7D6C58B522E499B9" modified="2018-09-12" version="1">MKTFFLRSSLLALATCALGASAIVTNPSEQHEPLDLDKRTFGLIPLSPCGIFKGGMSGISTYSSLSLNLGLTARVRCPLTFRCDGSGTDGHLYDINGLPVPSCFPSTWRYFGIERGWQPPASFSCGSSWTVPTAWCPSVHLAPWFRPGPGVALSYSSGLNIPSWWLPSAGWSCSGNLGIGGYAFDPYGQGPPIGASGFLYFGLGRGWLPPAGLRIDVNFIFPSGCGDLHLATWWSPPIEWVPPPKFGCPIWWKCKRCQSPTTSVTLSLPAPTTTTSAATIAQTTAAQSPTTSPHDGEHDHCSGHYIVVYLGFNDESSDHLDCCGDDIQHRELRNGHIIFDIHVSPPPTSHDRTQPPLHAEHHPHSPPPSLGPYYSTHHHVDRSIVDEYFVCFETYFDFRFDFDSDRDFEFDAFELRGSANDETSSQASPAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PCD9</accession>
    <name>A0A2X0PCD9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C030g10840 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C030g10840</name>
        <name evidence="3" type="ORF">BQ5605_C030G10840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000069">
        <property type="protein sequence ID" value="SGZ09094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PCD9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016046458" evidence="2">
        <location>
            <begin position="19"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ09094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="91" mass="9920" checksum="2245C4D64FA85757" modified="2018-09-12" version="1">MGHHPLLTLFVFPSAVLRLDLLVEFVRDETDDADGHAPDEKVDVEHALVACTVTAAGRGVRDTRLPTEKDRVGQRKGGKGVERNAFNDGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PD90</accession>
    <name>A0A2X0PD90_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C005g03718 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C005g03718</name>
        <name evidence="2" type="ORF">BQ5605_C005G03718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PD90"/>
    <dbReference type="STRING" id="796604.A0A2X0PD90"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY77753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="236" mass="25216" checksum="0CBE25FB40061E5D" modified="2018-09-12" version="1">MSGEVEVVRGKLRNRKGARTGIGPAAGEITRALRQLRAFKSPPQGGGLAGARPKWTLYTAVSWSSKRQTRVADSTTDAEYLALSHAGKEAIYLTQLLSELHVRPVDAAHIFTDNEAAAAVAHDPVHTSGTRHIRLREHFVRDMVHQGNISLSHVGTANMVADIFTKALGPKIFGVHCYALGLRTRHPRLKSTSRSRGGGCEESTLRSAQDLGARSEPGASAQDLGARSEPGASAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PDG8</accession>
    <name>A0A2X0PDG8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C029g10734 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C029g10734</name>
        <name evidence="25" type="ORF">BQ5605_C029G10734</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ16163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PDG8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="293"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="580"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1180"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGZ16163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1246" mass="136763" checksum="24E0015FD4EE76B8" modified="2018-09-12" version="1">MRVQLRSTNVPSTQSALLASSSSRPTRPKCLACHSPSHRVAECPVRAKHPPPGPCRSCKQNHWSFDCKKALENGKKADTANSTANSQHHVGCIATGFLARRRQLRTNSFVVDSGATSHMVSDKSLFTTYRHIAPTKIGGIAGGINAIGTGNIAFVAASGHPITLTGVLHTPGLFVNLLSVSRLCDTDDVCVAFTKHGIDIDKNGHNIAEGTRLDEGLYLLDADHSRCQHLALLSRSQSSVPLLTLHRCLGHLAPSSIQKMVAAGLLEGLGAGYSDEEVDKFVCNACLSAKGHRLPFPDSDSHSSERLGLVHSDVLSLPERSLTGKRYLVTFLDDYSRKLWAYAIGHKSEVFSVFKTWLAEVELETGATLKVLRTDNGGEYCSRAFTDFCKVRGTRRQYSIPRTPQQNGRAERVNRSIVEGILALLADAHLPKTFWEEAAAYFVYCKNLVQHSALDKATPNSVWQGGRTTASALHPFGCAAWLTVAPKLRSKLDPKAVRVLFTGYDLASKAFRFYDTTTKKVTLGRNATFLDTEFPGLCGDSAEPDDDTHFASAPFADPQTTVKSWTPLYSADPLDLIGSQPQAALDPMDTQPSDFSTYREPASAEESPDELDLIGRHSRDESPDEIDFLTRHHRAFIATDDDTSDTEAIEPVKSITSDPQTWREAMSGDKREVWAKAAADEFNSMRDDFKVFTIDDRSTVPAGATIVSSKFVWKTKRNALGEITGHKARLVAQGNRQRDGIDFTETFAPVARFSSIRSLLALAATNGLHVHQADIDKAYLHGDLDHDIWMTAPRGFDLPGDKVLRLRRSIYGLKQAGRIWNRHIDASLRDLGYTATGTDHCVYSRLDDRQRPHYIALYVDDLLMISPDLAEIERVISGLEQRYGVKRLGPAEYILGIQIRRLDDGSIALSQERYIMDVLARFHFDTTTRGTTVPMTPGLSLTAIPGQATERIRSWYLQAIGSLLYISLGTRPDIAFAVSYLARFANNPGHRHWIAVKHIFRYLRATYRDELVYTRGQARITGVVGYSDANWGACVDTSISTMGYVFYIAGSAVSWSSKRQSRVADSTTDAEYLALSHAGKEGIYLSQLLEELHVQPVAPAHIFTDNEAAAAVARDPVRVSGTRHIRLREHFVRDMVNRGDISLSHVGTSDMVADIFTKALGPKVFSTHCYALGLRTRHPRLGSASHSRGGGCEESTLSSTEAPRSSRAPASPPPCGGDLGARDCLSEQAPADSGARPLGRPLEVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PHF3</accession>
    <name>A0A2X0PHF3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C052g12565 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C052g12565</name>
        <name evidence="2" type="ORF">BQ5605_C052G12565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000099">
        <property type="protein sequence ID" value="SGZ29924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PHF3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ29924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="264" mass="29384" checksum="DD60BABAD7486DCB" modified="2018-09-12" version="1">MHTPKKQRTPTHPASKNSPKPTRGKAKPPAEDKQATGFQQKTFPLRKTADPANSTYKLALPQRYTSRGIRSTFHASQLNVFKFSDESRFPKRLVGSVPVYLIDSPMVIAYVPNHCMDSTTSRSASFNKLIAAGLHLGLAAQEYLAKNKVTTIWDLKPGKKEISIADPDYDFHLQRKPISRYTKASAASRNEPRGDRLNKGTQLHQRPRGNGRQADRITSAMEKTQQSQALLADSTAQPITITGRTRSRPYSRTPPALRPAAPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PHP0</accession>
    <name>A0A2X0PHP0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C032g11098 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C032g11098</name>
        <name evidence="6" type="ORF">BQ5605_C032G11098</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000067">
        <property type="protein sequence ID" value="SGZ04920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0PHP0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019783">
        <property type="term" value="F:ubiquitin-like protein peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="5">
        <location>
            <begin position="183"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="409"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="441"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="471"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGZ04920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1517" mass="167314" checksum="701F4EF0F690BDA7" modified="2018-09-12" version="1">MALGPFAFASKRASRCSRLNKSLAIFANHFSSVAHDEMIPCLFLDEDQDYYLHDDDFDRLSPLTNMTVAELLAFDVAPADASLHIELSKDEPTQYSTLPYPTLQTRDAFLATDALINARKKGYRSLAVGSTCLPLGADRLWSEYDRAKDVQSWALRAQRWMDKIIVINEIDRNQQDGLLPLPLLASGTSLVYLLRFLSHDWLGEAAVNLSIESVLRAGRVQNPDFETSCGLIPSTVISLVMARPPDSDPHSIFKACFFGPPNQYRNLIELSDCMRNTPSPKSIWFLPLCSDSHWVLARINMHKRTWSVINSLSATPITAATRTAVLTLFKFLKLDIKNEFSHTPKAEQQEDSYSCGPATINAVETEVLGIGSFNAARAHMSRLRQFCRLSSLVGAVEDPKEIESIVATGAKSKAKSGRGSAAGTLSSKSTSAESGKAATIKPTNQRVASSSKNPPTSRLQTTFTKASKPTKARELTPEEHTTWARDHPPLFRRLAEKVEDLCPGSNVDVNNPKDVRCGRCYVLVPMAALLCKAQFELHLGNKKCVNLQPISNFFRPIACGSTAPSPSLGPCPGLTSETAIHCLSSTAAQGGGAPPRRTLYLRLYPKIGKRPMTELERKEVDKLEANEWKWRNDHRAPRIISVNCRKYSARDSINKDGPSLPCEECAKLPKNSSCRAALRRQYAAGATRKYTNKKYVAGNTLLSAIYRRHHGLEEILDDNSQGTVYLRFAQGVASGEFDGANILEGLVKAATVKHDRMVKGKSMRGFVRSEALRDFEQAMALASPMALRVLQATIDASTSRKLQMDRATSGRMRLGLDKSNMDRVCAKLEADNLTFNLHVDDTKCRSRMRTTPYYSEDLSLERELRTKGIFRHELIGSIGPPRIYETPGELPDMFSGPDPPVAGTKIRAYMIAPNDVGSPAQVFAAFVIGETTNAEDATEQLHSVIQELIKRCVAHLLVSISADGAASEAVLQRHVAVLLRDQGGAVAQTGSRNASSYTLPSPDPDGVFPEIIISTVNVAGTPIVFCRDEKHLAKCLRNAIDSGARLLFGGLGCIAYQDMLTILGGLESRRTLSRRDVTKNSTPMRSYISSYVASYTMPSRTGRFSPLNVSGCCSLSGIRSRRGMTLSEVAPDLALTRSSPKKRLMGSGRWLTQRLLSSATTEIFGQRNRSFPGGMAQKWWSTSSGVYARLIRQATGKVTALLELMRKFKTEAAGSRQGYHHTYNDLDDLDLVAMRTYPSDGDISLTSFAAANTARELLSGLRMWEPVQRIASNRRNQGPQPDILVEEVLARGTTVQDLEDHHPTKEGQGLLRTELLDSALDGMRRSTCQGVVKPDPNEREAVDRAIRSLAALDFDVEAALFDVQIAYDEADRQAEERYVLETIEKANSPLRPIFLAELASLIAHRAAHECSHLRAVLLKGRPINTEQGRSAVHSRVLKGLVQSMGPSRFEDIAGTARSFRWTGGGQVARALTTNEIQKNAYIEDGRIQEKLPERDKQYGALAQRCPVWPSCPPKFWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PLK3</accession>
    <name>A0A2X0PLK3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C023g09638 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C023g09638</name>
        <name evidence="7" type="ORF">BQ5605_C023G09638</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ23810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PLK3"/>
    <dbReference type="STRING" id="796604.A0A2X0PLK3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="171"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGZ23810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="664" mass="73228" checksum="979302697638770F" modified="2018-09-12" version="1">MVDAESSTHTSPTAGSSTSNHVKRAAIACTRCQLNRKKCMRDARKQSACVACILADDGEACVVRDRARPNRGRRKAQAISASASPDSRHVSVNVHPLGPEGVVKNNAQALVPPRGLVQSVQEEVERIYTARTGLSLDLSLPVADLHSQNQSLLSSASFDALNIVNTTSLVNIFVKDMNHALVFLNKNHLWGIHAKLVASTASGESTLTPDEAALLDMVCCLGAFRALTFDDQSKKYVHPLSGERLDELWYRRSCAILDSWEGASLTALQALFLQYIYISSTGNSAKARRLLGKAVRMAHDDLKLNRIESTETFAPQDKAHLLYFFIYFADWYVEADRAALPSCCTHLDDRLHSHSYSYQSAICGLTPLVSLNDFDSAVLKPHLLFPKRAQTRPGGRSLPFVGDLVKLVLIQGDTLSALASNDDPDLATFRKIERKLTEWVQGRAPESASASWGEKTLATFCTIHFNWTRLMLYNGYMGRNPLLADGTLTTLLARSAVQIIEAYHEALQGNLNFPFHQLQRVITTAYVLLLLFVKGEMRMTETNRALSLVCDILKVLHTRWHSADQAHEALALVVASLANIFFPTLGLSPLVPLIKPNNALQPFNLALGPQALSDLDRTCIDASTLLPQPLGNNVFAPWTFSPDFAWDMMDFPLGFERGDKVGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PM07</accession>
    <name>A0A2X0PM07_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BQ5605_C024g09820 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C024g09820</name>
        <name evidence="11" type="ORF">BQ5605_C024G09820</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ26033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PM07"/>
    <dbReference type="STRING" id="796604.A0A2X0PM07"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000024">
        <property type="entry name" value="Calcium/proton exchanger, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF20">
        <property type="entry name" value="CA(2+)_H(+) EXCHANGER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="356"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="529"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="558"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="586"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="212"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="461"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="102"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGZ26033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="611" mass="65072" checksum="29F47BEA6CDB99D0" modified="2018-09-12" version="1">MNIPATTTFHTTSSEQQLSPVALADSSADVDEPPIKGSLPQFNTPKSSPPNQDHFHNEHPSAAPTTLIGTVDGDDEQQQQPLYARLRGRLLQSHATPERSASVPNLRTVSSDGSDPQVTPGVLRSNTSLSAAVANSTAPLYKSATSAQAQAQAAAAGRPIPFTEVLLTPKKPVGAPPGWKLSFINTLRYSYLNILLVFIPIAWAMNFSHQTAAVCFFTSFAAIVPLAALLGFATEELALRVGDALGGLLNASFGNATELIISILALVKGELRVVQSSMLGSILSNCLLVLGMCFFAGGLRFHEQGYESRSANLNINLLGVAISSIIIPVGFVAFVTDDNLLDAATTARDVMSISRGVAILLLITYIGYMLFQLWTHSYLFVPVVLEPGEKRRPIAAYIEGPQPPTEGGVFRIPSLPSWGGSSSSASSVLSRVDTNRSDHDAEAQSMQDKDHHTPRLSVVYAFVLLLIVTGLTGYTAEILVGSIDGLVSTTSLNREFVALILLPLVGNAAEHITAVTVASKGKLDLAMSVAVGSSIQIALFVIPLLVLIGWMIGQPLTLAFDPFETLILFLSICAVNFAIQDGRSNWLEGGTLMMAYVVIAIVAFYYPGTPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PN91</accession>
    <name>A0A2X0PN91_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C113g13234 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C113g13234</name>
        <name evidence="2" type="ORF">BQ5605_C113G13234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000107">
        <property type="protein sequence ID" value="SGZ30306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PN91"/>
    <dbReference type="STRING" id="796604.A0A2X0PN91"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031355">
        <property type="entry name" value="YBL010C/LAA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38698">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38698:SF1">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17104">
        <property type="entry name" value="YBL010C_LAA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ30306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="408" mass="44197" checksum="46563EE7A8F5DDD4" modified="2018-09-12" version="1">MSRRRSSMCRLGNKSHQQRPQSQETSSTRGPRIRAASPDEDGKDSEGYSSPPPAMPTTTRTTLTISARPQRQVAMPTDAGFGDFGHFGDTHEGDVHASKALTSSHRRPSSLPRPEVTPIASSSFAAFQSTGHPPLLLELTNPSKAAIEEQLHDFFEGVYPGARGMVSDEPERQVEGVGQVLASESDVSRRTLLAGLSSLPALKPLDWRRSRIRREHLITLGVPINLDDVRWARHPPFHVVQTNTSLLLQTAPVKQLASLTLPPQRSHSPHTTRSPTSAFAAGGSISRSTTHFADRERARALHQVPILDRKLADSLLALREHDLVGLSLADLQRKVAEMDRVTEEASAALTHALVTRDKESGDAETYNGMIQDLVAAAAKTKTTSAAGGRSSPALRTASGGRWGRSVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PNF2</accession>
    <name>A0A2X0PNF2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA sliding clamp PCNA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C027g10383</name>
        <name evidence="8" type="ORF">BQ5605_C027G10383</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processivity during elongation of the leading strand.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the PCNA family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PNF2"/>
    <dbReference type="STRING" id="796604.A0A2X0PNF2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043626">
        <property type="term" value="C:PCNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019985">
        <property type="term" value="P:translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00577">
        <property type="entry name" value="PCNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.150.10">
        <property type="entry name" value="DNA Polymerase III, subunit A, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00317">
        <property type="entry name" value="DNApol_clamp_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022649">
        <property type="entry name" value="Pr_cel_nuc_antig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022659">
        <property type="entry name" value="Pr_cel_nuc_antig_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022648">
        <property type="entry name" value="Pr_cel_nuc_antig_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00590">
        <property type="entry name" value="pcna"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352:SF0">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02747">
        <property type="entry name" value="PCNA_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00705">
        <property type="entry name" value="PCNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00339">
        <property type="entry name" value="PCNACYCLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01251">
        <property type="entry name" value="PCNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA N-terminal" evidence="6">
        <location>
            <begin position="38"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA C-terminal" evidence="7">
        <location>
            <begin position="179"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA C-terminal" evidence="7">
        <location>
            <begin position="370"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="234"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="247"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="301"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="350"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGZ28593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="435" mass="48423" checksum="DAAD6C7511141255" modified="2018-09-12" version="1">MFVSACFRLDTKEECHVDVRRALSQAIDRIDALARPQEARLEQAEVLKKVLDAIKELVTDANFDCSDEGLKLQAMDNSHVALVSLQLDATGFQRYRCDRNMYVPGELVGPRKATRRVPTDCDGSSSLQKIIKCASNDDIVTLRADESQDVLGLLFENGKHDRMGEYEMKLMDIDQEHLGIPETVYDAEISLPSAEFARIIRDLKELGESVKIEVSKDGVRFSCEGDIGTAAVTLKQSDGAKDGERMEQDEEEDEEEDAEEEEEEVAEEEPKEEEDAVVIDDEDEEEADVKPKKSKKKAVIVDDEDEEADEKPEVDADEEDEEEEEVVASKSSKGKKAAANGKDKSKKRKAPEANGKKGKKAKGDVDAAAARKVTINLSQAVNLTFSIKYLSNFAKSTPLSDTVRLHMSNEVPLLVEYPFEGGHIRYYLAPKIADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PPZ9</accession>
    <name>A0A2X0PPZ9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C042g12018</name>
        <name evidence="12" type="ORF">BQ5605_C042G12018</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000116">
        <property type="protein sequence ID" value="SGZ31846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PPZ9"/>
    <dbReference type="STRING" id="796604.A0A2X0PPZ9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038:SF16">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="11">
        <location>
            <begin position="24"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGZ31846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="96" mass="10263" checksum="C6211251CE62853A" modified="2018-09-12" version="1">MSFFGTGARSAPAAGQLDQQRLGEAAMELEAVSDLFNRIVSSCHAKCISTRYTETELNKGEGVCVDRCVSKYFAANEKVQERLQNAQKAGGGVAGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LQI2</accession>
    <name>A0A2X0LQI2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C010g06063 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C010g06063</name>
        <name evidence="10" type="ORF">BQ5605_C010G06063</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LQI2"/>
    <dbReference type="STRING" id="796604.A0A2X0LQI2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08044">
        <property type="entry name" value="TAF5_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.500">
        <property type="entry name" value="TFIID subunit TAF5, NTD2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007582">
        <property type="entry name" value="TFIID_NTD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037264">
        <property type="entry name" value="TFIID_NTD2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF1">
        <property type="entry name" value="CANNONBALL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04494">
        <property type="entry name" value="TFIID_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160897">
        <property type="entry name" value="Taf5 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="TFIID subunit TAF5 NTD2" evidence="9">
        <location>
            <begin position="136"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="460"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="530"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="578"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="620"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="662"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="704"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="45"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="330"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="45"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY14104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="873" mass="91717" checksum="C261DA0C04188874" modified="2018-09-12" version="1">MSSLPASSSALGQTDQSYKAIVDYLTKRGHLKAVAELQTDLANSNTSAAAGNTSGSATGNASTSTAGGGAAAASSSSSHPASPAAALNGGGKAVGLDDFAHRNAPSQPTSRAQTGGAAGERRGPDQAVAAGQMLADPPSWEKGYEGLTAFVHNSLDIHRPELQPILLPLFVHAYLDLVLVGYRDAADQFMNRFGPHHTPSDPHVVRMLSSIRNADHVKESEEATRWRKESYNIRLSERGWGLLLGWLQGGGLALSLEGTESRGRDRVLAIINERVKVDAMPGPPSKTPTGYGLLSDFAGKEPSSKALDPLKLGPAPVDPNLEREVARQVKDDAAQDAMDTSTPSANGINGSTSTSEAKVGAGSTPHAIDFADASPHAENLPLINPVPSDMLPMPQTLRTIDVMREVEKVREARKRIKLSAEAYVAVPATTTMNGANGDKVGVPLGQVTEAAKPSVCIFTIHDAGDSLTTTAFSDDSTMMAAAFSDSYIRLWSLKGGKLQAFKNDLNPDEVKEVNDLKKIREKAAPTSRKLIGHSGPVYAVSFDPVPGPSGPPRYLLSASQDATVRLWSLETFTNLVAYRGHREPVWDVEWGPRGIYFATASRDRTARLWSSDKTHALRIFAGHLSDVNCVRFHPNSLYIATGSSDRTCRLWDVQKGTCVRVFVGHRDAVTCLAMSPDGRYLASAADDLTINLWDLASGRLIKSMTGHTSSIYSLSFSAESTVLVSGSADATVRVWDVLSNPYAAEMNGELIPGSGRRAGMGGSLGSVTRMSFEQVKGSARRASLVASGLGGGGGGGGGAGGNAGSAAAGGMGSGGVLGEGGKGQWVKGTLAEKEAKESPDLLATLATKRTPVLAVKFTPRNLCMAAGPMQDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LQM8</accession>
    <name>A0A2X0LQM8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sulfate adenylyltransferase</fullName>
            <ecNumber evidence="9">2.7.7.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP-sulfurylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Sulfate adenylate transferase</fullName>
            <shortName evidence="9">SAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C010g06113</name>
        <name evidence="9" type="synonym">MET3</name>
        <name evidence="13" type="ORF">BQ5605_C010G06113</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>sulfate + ATP + H(+) = adenosine 5'-phosphosulfate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18133"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="EC" id="2.7.7.4"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Allosterically inhibited by 3'-phosphoadenosine 5'-phosphosulfate (PAPS).</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 9">Homohexamer. Dimer of trimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The adenylyl-sulfate kinase (APS kinase) is non-functional. It is involved in allosteric regulation by PAPS. PAPS binding induces a large rotational rearrangement of domains lowering the substrate affinity of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the APS kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the sulfate adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="9"/>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LQM8"/>
    <dbReference type="STRING" id="796604.A0A2X0LQM8"/>
    <dbReference type="UniPathway" id="UPA00097"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010134">
        <property type="term" value="P:sulfate assimilation via adenylyl sulfate reduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00517">
        <property type="entry name" value="ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.400.10:FF:000003">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000802">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000052">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.10">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03106">
        <property type="entry name" value="Sulf_adenylyltr_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059117">
        <property type="entry name" value="APS_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025980">
        <property type="entry name" value="ATP-Sase_PUA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027535">
        <property type="entry name" value="Sulf_adenylyltr_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050512">
        <property type="entry name" value="Sulf_AdTrans/APS_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024951">
        <property type="entry name" value="Sulfurylase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002650">
        <property type="entry name" value="Sulphate_adenylyltransferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004040">
        <property type="entry name" value="PRK05537.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00339">
        <property type="entry name" value="sopT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42700">
        <property type="entry name" value="SULFATE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42700:SF1">
        <property type="entry name" value="SULFATE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01583">
        <property type="entry name" value="APS_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01747">
        <property type="entry name" value="ATP-sulfurylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14306">
        <property type="entry name" value="PUA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-sulfurylase PUA-like" evidence="12">
        <location>
            <begin position="4"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Sulphate adenylyltransferase catalytic" evidence="11">
        <location>
            <begin position="175"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="APS kinase" evidence="10">
        <location>
            <begin position="396"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Allosteric regulation domain; adenylyl-sulfate kinase-like" evidence="9">
        <location>
            <begin position="396"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="198"/>
            <end position="201"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="292"/>
            <end position="295"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="435"/>
            <end position="438"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="521"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="9">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="9">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="site" description="Induces change in substrate recognition on ATP binding" evidence="9">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00062002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGY14238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="576" mass="63647" checksum="1E0EE2F598C024A3" modified="2018-09-12" version="1">MANAPHGGVLKDLHVRDAPLQQQLLAEADALPDLLLTERQLCDLELILNGGFSPLEGFMDQQDYESVVQTLRLSDGNLFPIPITLDVSDENIKALNIVQNARIALRDPRDERALAILTVSSIYKPDKVKEAELVYGANDATHPSVKYLQASTKDNYIGGNVQAIQAPQHFDYVALRYTPAELRAYFDKLSWRRVVAFQTRNPMHRAHRELTVRAARQQRANVLIHPVVGLTKPGDVDAFTRVRVYEAIIRTYPNGMAALALLPLAMRMGGPREAVWHALIRKNFGATHFVVGRDHAGPGKNLHGVDWYDPYGAQDLVRKYAGELAIEMVPFKMMSYVPATDDYHPIDEIAKGTQTLDISGTELRRRLKTGAPIPDWFSYDAVVKILRESYPPRNRQGFVILLSGFVNSGKDTIAKALQVTFNQQAGRTVSLLLGDQVRSELSSELGYAPEERHKNLQRIAFVAAELSRAGAAVIASPIAPFEHSRAAAKQYILQNGGAGGGTFFLVHVATPLEYCEATDRRGVYKKARAGTITGFTGVDSPYEVPNNADLVVDLSKQTPLEVVHSIVLMLESEGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LR00</accession>
    <name>A0A2X0LR00_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar protein sorting-associated protein 28</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ESCRT-I complex subunit VPS28</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C013g07055</name>
        <name evidence="10" type="synonym">BQ5605_C057g12682</name>
        <name evidence="9" type="ORF">BQ5605_C013G07055</name>
        <name evidence="10" type="ORF">BQ5605_C057G12682</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the VPS28 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY14722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000094">
        <property type="protein sequence ID" value="SGZ29404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LR00"/>
    <dbReference type="STRING" id="796604.A0A2X0LR00"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1130:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 28 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007143">
        <property type="entry name" value="Vps28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017899">
        <property type="entry name" value="VPS28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037206">
        <property type="entry name" value="VPS28_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017898">
        <property type="entry name" value="VPS28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038358">
        <property type="entry name" value="VPS28_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 28, ISOFORM 2 VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03997">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017535">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140427">
        <property type="entry name" value="VPS28 C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51310">
        <property type="entry name" value="VPS28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51313">
        <property type="entry name" value="VPS28_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0967">Endosome</keyword>
    <keyword evidence="4 5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS28 N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="VPS28 C-terminal" evidence="7">
        <location>
            <begin position="114"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY14722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGZ29404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="219" mass="24597" checksum="A5D9E6AC4E193C04" modified="2018-09-12" version="1">MAATATTRFNLDEAATTNADRERIDELATLYGIIVQLDYLEKAYVRDSITQAQYTPACSRLMAQYKTILKLVGDAVPTIEAFMLDYRMDCTAAAHRLRVGVPATIEHASEEGVETAQHVAEVTGAFITLMDGVKLNLRSKDQIHPLLTDLMSGYTRFKNSSQWEGRPKLLNWLISLNQMRASETITEEQARDLMFDVEQAYSELVLSRLLASMAEIAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LS32</accession>
    <name>A0A2X0LS32_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C011g06311 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C011g06311</name>
        <name evidence="2" type="ORF">BQ5605_C011G06311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY11899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LS32"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="400"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY11899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="793" mass="83774" checksum="44A44B4199B47F49" modified="2018-09-12" version="1">MPDPPGAQAPPPNTPLGGNRASDDKSLNTLTHEPVTGGTANPPAVLGIVPSGKSTRQLMVLMHNALTPPSQAPVLARAAQRAVQNDAAPASNVIQVIMDGPVQIALRKHFGLAETPFMFAPPEGVVLDPEVEKLFSKCVKLNPIVTKATKRFPIAPGPFSHHGKEMVTELPSASPLNHVVQVRFTLPSSSSAIPASVLRKSLDDALTLSFGRAGRTQGYTLMQLQRGLAVDPNGDPMAMTKDGFHCAYLRLHADLFQGSTETQKAALNTALPQEIEILGAKYGLRHEFETHYCAVCDRAGHQWGACRKPVSTPAAAAPVPGASTSTSTTGFRVAGKNGKHGGPAALNSRASGTNMIQLGPRANPAGAATGNKDDANDGGKSVASTKPEGGDTGKETLTRATTGSTKETQTTTAAPVSTPTSPSPSASAPASPLSGGTSGSSATLTTSIASTSPRRLRSSSAPGNRRVTRAGSVMILGASGGDGSGGNSSGVNQVKIIRYLKTLRPAPAAILLQEHHLSYNASREVFESAWPGACILFTPHVLTLIPDGSPLAGHLLSSTPVVFAGPPRFDGRILRSVFRLEELDVEIINMYAPTLLSKIAFKALDTVRHVHSCTPAFTRPHYRGRGEERKIRSWSRIDYILVQCSWANRLLSASTLFDAPCSDHRPVVATFALPTSNADAEPPLSLLSTSDFISRLNPTVFDDQDFVASIPGVVDEVYRRLKGTAPLGDVYDAALRAVAVAGHARYRSTRADMRRLRAESQSVMEALEARGEHMNEAERDAYAFATSATLPLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LT21</accession>
    <name>A0A2X0LT21_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C015g07870</name>
        <name evidence="13" type="ORF">BQ5605_C015G07870</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ubiquitin conjugation factor E4 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LT21"/>
    <dbReference type="STRING" id="796604.A0A2X0LT21"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000055">
        <property type="entry name" value="Ubiquitin conjugation factor e4 a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF2">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="12">
        <location>
            <begin position="1041"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="8"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGY17721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1124" mass="125209" checksum="2BCBFAD0DF1F682F" modified="2018-09-12" version="1">MKRLAKLQQSQPAQSSSSSEASTSTTSTSRASATVPAPAPARAPSQSPSQSRGSIVLPAAPVQASLSNKSTPIPTPTPTPSTSKAVGASTPQATLPRSTSIESFEDWQHTILQTVLRVTLDREQAEAFNWSITYLKDVAEEIAAETAPDRATPLKLDAESIDRLLLARLSLSPSVMTDDPEIITVVAALPENQTSFGYLGGCWKRERAERQKLLSRKNLSAADLSARVEVLNKAKALIVSYTGLVLIDPSMFPQEHTTPTSPGPLELAGLLLPMSNTGPKTSTLQSTDLPALLQDLAGRFTPSPANDEEGGLEEVIGPLISYLGTQLIAHKVDIGGSTSANGASWRDVLGAVQTLSEIKGVASTLPQCHNWVVTGTPQAQAPLIEMLSLLGPFLRLSAFPDSFPAIAKVYFPEPSTQGRGNLDSAAQSLRGTLSGVQHILFQILNNVVRSGPVAREAVLSYFGNVARANVKRSAMRVDARTVSSHGFIINLHTALLAFAQPFTDAQFSKIDKIDSLYYRKSRRIDIADETKMSATQSESEEYYLQAADEAQLEPVNFISEVFFLCCTYFRLGIMHAIKEHKGFSQQIRHMTRELADMETDQTYRGTPGEARALAEIERYKKRAEMFKSHLEAYQVQLFDTTYLSNCLGFANLVIAWLVRQVDPKKQHPQVRVQLPMPDETPLGFRMLPEFLIEDITEFLSFASKAAPLVLAEQSQDELVTFMLVFLSTPYMKNPYLKGQFVEIMYYLTRPMPRYPTGCLGDVLNFNPLALKHLMPCLIHAYIEIEITGSHTQFYDKFNTRYYITQLFKLVWSNQSHREALKLESQLIQLPCRNLDRYVRFANLLMNDTTYLLDDALSHLAKIADIQKQMDDRAAWDARPVAERQEQEKLLRQYEGQVRGDLDLGTESLRLLKLFAGEAQEPFLTPEIVDRLAAMLDMNLSMLAGPRCQELKVREPEKLNFRPKELLSDVLAIFLELGPRSEFQYAVAKDGRSYSKDLFDRATRIARKTAIKTDVELREIVQLVEKVEVIKAAEEEDDAMGEIPDDFLDPLTYEIMRDPVRLPSSKTVVDRSTIKQHYLSDATDPFNRVPLKWENIVDAADVKEQIEAFLAERKAKRLAAKGAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LTU9</accession>
    <name>A0A2X0LTU9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">rRNA methyltransferase 2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C010g06098</name>
        <name evidence="9" type="ORF">BQ5605_C010G06098</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LTU9"/>
    <dbReference type="STRING" id="796604.A0A2X0LTU9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF18">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="8">
        <location>
            <begin position="83"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="302"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY14200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="337" mass="36789" checksum="D47581946AA4730E" modified="2018-09-12" version="1">MPSSRILFPARIPPRQRLLNPSHPCPGSWRLSPPGSALPTQHRSTSSKSSSSSQWLSRQRRDPFVRSRTNTLLDPSSSSAQSYVARSAFKLLELHQSSIGGGRRPLVRKGMTIVDLGASPGGWIQACRTLVGSSRSSGRATSGAQAPRTRIIGLDLLPLDRSLDSDPDLEFLQGDFLDPYIQAQLSELLGQDHVDLVLSDMLNNQSGSTLRDSQSSIDLCRSAWEFARKHLSVDKVRQTEKEGDAAKSWPSIQLVIKCLQSDLAIELGNELRGDFQKVRWEKPKSSRADSREGYWVCLGFKGRGGAGAGKESKEGKGKTGAGKVDEGVEESSDGLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LUC5</accession>
    <name>A0A2X0LUC5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C010g05979 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C010g05979</name>
        <name evidence="8" type="ORF">BQ5605_C010G05979</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LUC5"/>
    <dbReference type="STRING" id="796604.A0A2X0LUC5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040107">
        <property type="entry name" value="Snu23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986:SF1">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="39"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="97"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="241"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY13794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="293" mass="33007" checksum="9DE9192E80C93CDB" modified="2018-09-12" version="1">MLEPSSTHQLVAMPNRAKSEVDNGVVFASAGGLATVHRSAARPFAPTNRQKRRTPQQQILCSVDQQSPIMSKTGAYGSSTVKDTAFRKEWNDEEYTNKAKEKDKELHDRAVENEEYLKQGKKPPRRAKEDLPKPTQLMQARDAPLELDKNLNKTIIINAGAGQGAGQPGFHCDVCRRTLKDSVAYLDHINGRSHLRRLGQTTKVKKSTLNDVRQKIAELRAKTAQSAESKKYDFDQRLKEIRELEKQSKVEAAEKKRLMKLEVEKEREKERMQGVDQNMMAAMGFAGFGTTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LUK4</accession>
    <name>A0A2X0LUK4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C010g06049 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C010g06049</name>
        <name evidence="2" type="ORF">BQ5605_C010G06049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LUK4"/>
    <dbReference type="STRING" id="796604.A0A2X0LUK4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040144">
        <property type="entry name" value="RAP1GDS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10957">
        <property type="entry name" value="RAP1 GTPASE-GDP DISSOCIATION STIMULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="603"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="704"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="537"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="614"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="706"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY14068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="855" mass="91095" checksum="7830460739B58305" modified="2018-09-12" version="1">MSTENEPEMTEIGTAIDQLERLADPTASSTTTTQWSDVANHAKAIADSLKTPELRTTLGNTSLVKSATSLLKTSVDAPNGEDVLAARTELLRLIGNMCFDNDPNRAQTHSGAGPESILELLANLFEIAPPTSSTSSSKVTQVSAGKTRPLSTAELKFVRAAIGALLNASLRYDPIRKALSSPAAVTTLLAIIDTRNTPDRAIAPIYVVGSWMLNPGQTDEDEWTERIELGSTIAGWVMSILEDVLADDKNSFPPEATAALFSIVNSLPPTDSKVPPYYIWEAEESSDFVDSDIELLTHVAALLEAISIDLVAVKKQLAFADYVPEQRLLPLTFDFIESARLPDAWLTIAGTERVNVEKAFAMVKAAVVRAVVEAPNDDEVMLDFMRQEWLVKRLIGWLDLGQTGERDDLLVCASHMLAAIGRKDEHCVALVQTYGLAAPLAQIARRKAMQQFQKESSKPGGEVTQVLFGVISLLRHLSIPVSNKSIIGETGIITIVSMLLVPTLDFVAPLQNAVVGLLKHLTASNVYNSLRLLGAPASSTPSSVPSPSNGGEAVSQPALPTPPSALDLLVASIRRTDNVRLRSEATRVLANVVRSLFSTRVNSDPSNLAAASPITPSMNQSNHSGLPSSGGNAGGVDTEESLKRRGRPRVLRKDVVEALTEMVRLSEKYPMLINEAVVALTLVAGSGGAGAKLVLESLTTVHAPPAQTSADPSAVVSPTSPLSPSRKQSLALTDAGDPFSAALMAAGWLSLYSNPDKYEALSAPLKPTSSADVLASTVRPEMIGNLCALLITTLRGSEVARIESDKIDKLKLVVVGPLKGVQEALSSEPVKESLKGGVWDALRRTVARANEVVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LUR1</accession>
    <name>A0A2X0LUR1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C010g06037 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C010g06037</name>
        <name evidence="1" type="ORF">BQ5605_C010G06037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LUR1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY14040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="715" mass="80415" checksum="1DD855DDBA3902DB" modified="2018-09-12" version="1">MQLLSRFFRKRSADNTDAKMKQLAKLSGARLQQAKVTDYGLAPVLAPGLELIRYRSFARAFSDAIFIPNADDRLLMEARLAKLGMTWEEAVRSPVWNKKLWRRVRRWIPPPGILEPLVREVFEKLAKRCLEAIRKGQVSDPVGIELYTDLGPCGGPDGKADDGVRLYSCQRGTNSLEGGIHRNLRQRFPKSGVSPCHANACLADYVLVHNLTVSPTPPSQFEEAATILTHYPLYSQVGTSNRTGKPFVGHYGLWLTVELHRLRRKTSAFFPRHSTTVSDIVNLLLYTPSTETFGIVLVVQSPTAQMRFLIEPYQVERGTLRLEPVKWSPRNLLQNNTPAIQHMQSRLPTDRKLRHDWPAKRQGTRFAVLYVHTPSERALYRYLSSKVRLGAPQNLRIFEITEPWNKYANGLDIFYKMPEHINTWAPRWSSLANAQATMITATLCQGSVSHHLRILIQAIRCSREAPLAQDLQQPLPPENPRRPQALPRARVSAQAFATSAETALSASIIIDTRATPRKAPRYTSDGLFGFCCKDLTRRFRLARTDPLPPVNAIAVLPTHAGSRAVLATHVPFWAFTVLSRFPTVDAIAVLPTRELTGGTRNACSLSGLHCVVDVSLPASMAAFTTCRDRCVPHSQDYFPADEVADREFHLAGRSQLLAARYETLDVARLEQLGLPIVIPPTIPVYHQEFRTLLRLDQFLAVFPRRPGFSPLEVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LWR6</accession>
    <name>A0A2X0LWR6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C018g08700 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C018g08700</name>
        <name evidence="8" type="ORF">BQ5605_C018G08700</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY26105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LWR6"/>
    <dbReference type="STRING" id="796604.A0A2X0LWR6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016143155" evidence="6">
        <location>
            <begin position="21"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="103"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY26105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="461" mass="49980" checksum="72CCE3E8DA26D89E" modified="2018-09-12" version="1">MMLRFLACLVVVDLASIVSAVPVNSSRQAGTFLSCLSSQPSLNLATWHKDRREFTNLTAAFNQRLYSSASVAVSPKDANAVAAAVTCAQKFNRPVTARGGGHSNLQNIELKEDNFTVVVGGGALLGDIALQLNEWGLAMAHGTGPMVGVGGHAGFGGFGFISRKWGLTLDAISAFDIVLANGTYVQGLTREQDPDLFWALSGAAPNYGIVTAYHFVAHQKPTNVVQFDYGFRGLSPAAMTQAFLAFQAWGKNSSPPELGIQAVIGANGSLDLSGLYYGSGENFTNLMAPDCFYARSLMTPDSDQLITEEAANAFFSYLQNTETTTQWFVEIDLYGGAGSYINSVPLNQSSFAHRSSLLTFQLYASSPTLNNPFPDYGFSYVDGMYNALVDPMKAAWSTTYGSYVNYIDPMLSPSEVKALYWSSQYDRLSQLRAKYDPDQTLWNPQAIQPTAVASRRSVREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LY73</accession>
    <name>A0A2X0LY73_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C014g07683 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C014g07683</name>
        <name evidence="2" type="ORF">BQ5605_C014G07683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY19556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LY73"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="769"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="835"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="942"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="942"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="958"/>
            <end position="968"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY19556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="985" mass="107228" checksum="6E752C5BCA052DF0" modified="2018-09-12" version="1">MDMLDTGAGTGASMIDNKTQSTSSPAAPASSQTPSSTQTTTTTTSHTLPAPWILPQPFGPIIDLQPFTLPEPPRRKTTPPPSPDHRLESKFSSETLGVAASSNPNSLISAGFRLHRLFTRDSMQFSPTSEGSSRSYTRGHTASRSCDRIESAHGHGHGHGHGHGHGHGHGHGRRRSRSRSGDSACKEEIVEGSSRSTDGRWGVGGIAKEVVETLKKRRQGSKSNESGRASPVDNREQVPRSESPALSMQNGSLDLLRVKLPGSESSPHRTPQSSPTRRPPEATGHRFSKSASDIVLPPPRSDSRLQNPDPAAQAAVNNPSSSQLTPRRPPPKASCRKPTAPPTRPLPARPISPPSIPFGVRPLFVPKRFPSPQPLPGTPSTFDVFTPLPSTPLAPMNVGENSYEQPTFSALILERPEPFDIEDKTPETLLIKLNIGAEVHLTTLSTLTTRNRAGKLADFVQAAVNDIRRHSPDAGLAQPEPSCIRSPSAYASSSDDGESIILNASHFATSRSPSPFPYEEHCGTTAQSHETIAVCVDSFKNDPDEVLDDDCEVIDPFILSYGELAKKVRTRLGQHYLEPNDSRRRTEMRTGSSHSQLAEKKAKLFLPLPTFTSPPLAVQHHPKLCKTPSPRNRIHSIHPQIVRPESTLEFGTDSDDEIESQSTSITLPSLGTRDTNLFERRLKGHLITETPLSPLPMPSEGTSSEKAHAMAMARREVKSVPVDVLADENDDDEAVPRLPQRMECVVPRLNIINQVAESVETTDVKQTVPSTVKDTTPLRGSLVSGPHSFHETTKLPSPPLVSSKQQQATIQVLTIFLDRPSLPYVAIMSYLRSAASSPSGKGILPPSLTFPTSSAETQPQAQPNPHPHPHPYSTSTASPNHLDRTHLDLLHLSPSILMHRISSLRELAREAHYLGMSELLELIENERSTIVQAVRVLKAEREVEKRKERERRGGGGSTTSSPKGTPPVLRKVESVLRERKAAGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LYT3</accession>
    <name>A0A2X0LYT3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C002g01466 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C002g01466</name>
        <name evidence="7" type="ORF">BQ5605_C002G01466</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY33212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LYT3"/>
    <dbReference type="STRING" id="796604.A0A2X0LYT3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF85">
        <property type="entry name" value="DUF803 DOMAIN MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G15880)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="388"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="388"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY33212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="415" mass="44110" checksum="FDCF2A8E4843C040" modified="2018-09-12" version="1">MDDASLVQTPDGTRDKYIGLALAISSSIAIGTSFIITKKGLISAADRHDGLSSSATYSYLKNGLWWAGMITMVAGEVANFAAYCFAPPILVTPLGAGSVLVGAVLASFFLGEQLGRIGISGCSLCLVGSLIIVLHAPEDKAIETVDEVLAYALQPGFLFYCFFVIVFSVYMICRVAPVSGSSNPLVYISICSLVGSVSVMAVKGFGVALKLTIAGNNQLWRPGTWVFAITVVGCIAVQMNYFNKALDLFPTTVVNPSYFVGFSTSTLIASIILFHGLNTSGGKDTLSLLCGLYVISLGVYLLNLSRSENENSSGGLTRLNRHSHSMLDNGILGRTSLASNRYSMNSEVDGNPDARKSTNFFRGGGAVVGGVEPMNHANDLHLPMEEFEEEFEEDDADDGQGTAYPHKGKALNGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZB0</accession>
    <name>A0A2X0LZB0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BQ5605_C016g08133 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C016g08133</name>
        <name evidence="11" type="ORF">BQ5605_C016G08133</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY20722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LZB0"/>
    <dbReference type="STRING" id="796604.A0A2X0LZB0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="404"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="489"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="518"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="551"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="584"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="167"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="75"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY20722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="615" mass="67339" checksum="ED8F55EB492E6E26" modified="2018-09-12" version="1">MILGTLPGRPRQSGELLIPSFGAAEICRKGPAVDGINQSVGPSADHAVWSCTTGYRPIPVVDLRQDMKEYEAFGDAEKALSSRSSTPSPAPLKDAPPQVTPSAMAAVGSSGAASGTAAAPAPRFTSLTGWISHASRHEPPRVMITDQEWERRTENPRNWIQSRRIKNTVIISLTGFLATLASSILVASSSILREQFGRSREVVTLTTSIYVAGLGCGPFLFAPISELYGRQIAYSSSMILFMILNLVLCFAPSFSSILVLRLLTGIFGSSGPSLGVATLSDLFAPKERGKPLSYYALGPMAGPTLGGVMGIYLALVDASPMFPEFWRWCFRLLAILVGLNTLAIIFLMDETYAPVLRKTLEEEDGVAISRLARLRQLFRPKPEAKAIMIRTFTRPPRMLVNPACGLFVVYYAYVYSIIYVFLVSLPLLYSRHNPPDALFTYNWKPKITGLSYLGLGCGFFSSAFTAASLQDRIYGYCSRRYKNDGQPEYRLCITQVGMIIFPIGLLIWGWTAQAQTHWMGPITGSFILAYGLMLCFNSIQNWIVDAFSPYSAAAMAGATIVRSISGAILPVFSDSLFINLGYGWGGTLLALPAVPAPFVLFMYGQRLRERYKFQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZN6</accession>
    <name>A0A2X0LZN6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C002g01713 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C002g01713</name>
        <name evidence="1" type="ORF">BQ5605_C002G01713</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY34998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LZN6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY34998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="676" mass="75040" checksum="E271B7FCC29F8E04" modified="2018-09-12" version="1">MYLDSPDIELLDDDFERMAPLLDVRVSELLAFRFDNPETQIQLSWSTDEPLEFETPPRPFDAWRDKFKDRGAIIAARNQGYRSIAIAGLYLYDLAPRSLPLASTCFHEFLSLSLGFPATINRASVIWRHIDYAERMRSIVISSQEWMKTYLGVNIEDQPLIVKALEVLPSLIVEEQYTPSMILGCSTSLRTLLDFVGTTWLGETAMDVAIASVLASSRVEASTAPDKSASKVTALLGLMRKLKTETAGSRQGYHHTYDRLDDLDLVAMRTYPNDEEIRSTSLVAAGLAKELLLGLRMWDTTHYQKSNQVKEEIPVNASEPSHFEPEDTEPVSHVADLDRTLNGIRTKTCQGLVVLDPKERKSVENAAYDEADAQAEERFLLDAIETANESLPGRAQILRLPSLLRHDPRQLALDLKSLIEHRRAHQCAHLKAVLLKGRHGAPTSTAQDFDPTSKAQLSEHGEVHSSVLRGLVQSMGAARLEAVSGVARSIRWTGQGTFSRFSTANETDNIGYIEDGRKEVRMQLRARQYTVFAKIPMFGSIDGNVTSAMPLKIGSLVCFGLKRGIIPVSCDASNIGEEQLSIGLVRYMYAKATSNHCDRAETDPLALLSNVVLQELRVVSKGRYSTHMIDGTTRFFGLDARQSIQSLESSSTPGLTRTPGFSCIPRGACLRLWPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M0S8</accession>
    <name>A0A2X0M0S8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C018g08719 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C018g08719</name>
        <name evidence="8" type="ORF">BQ5605_C018G08719</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY26314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M0S8"/>
    <dbReference type="STRING" id="796604.A0A2X0M0S8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF97">
        <property type="entry name" value="ADIPOR-LIKE RECEPTOR IZH3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="481"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="511"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="554"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="580"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="613"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="642"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="682"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="535"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="680"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="684"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY26314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="728" mass="80086" checksum="181A48EE2C8B0D6C" modified="2018-09-12" version="1">MSRRRSSRVSTSGPSASASSSGPALSSPFCAPAQPAISLSPPSSPNSAETPVDALSDIDQSKRPTLRPRAKSMHHTMCPPLSSSASSLDYGSALLTSLDLSGSIWTLREYVLGRVDQVEHNIQLLKVYVAESESEDCRSGDSSCVEPETETETENERDNEALETYDDEIESLAKLSESECDVIVNAVRSRRRRAAVDPALTAKGQPTWEQVKQEISALELFITKASRFLNAVRSGWPSLSTLNSPTYVDGTTLPALVQFQLSPEARQALDHFLEDHPIPSLPRLNFRARFDNGRQRASDSASALLSRVSSELAALQHVLNSHSTTERVSSFMPTLPTLPSTPAVVLTEMRDYFAAESTRLGGALQRYRPGAATFDKVSNNLRTLRNEASDSLQAGVAHLQDGANELTALLSSSSSAALDEAAKFYHAALSRGKERLLRYEELPFPWRNNEHIITGYRFYPIERWGVLLRSAFEIHNETINIQSHFVGFLSLVYLLVYVMPGSPHWLPNSHWADTAIALVFVGAAMKCLLCSTAWHLMAGCATDHWHRGAACVDYVGISGLIAASVMGIEYYGFYCRPQLATVYIVFSGALGVMGMVFPWQAWFNEREYKSVRIAFFLSLGGSAIMPVLHMAVLYGLFDTVKYLMPVGLSVSAYLVGLSFYGYQFPECTAPGRWDIFFASHQVWHVAIVFAVWAHWWALSGWADLASQGMDLSCSATNLLNSCSYSPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M5Y6</accession>
    <name>A0A2X0M5Y6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C003g02432 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C003g02432</name>
        <name evidence="7" type="ORF">BQ5605_C003G02432</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY40855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M5Y6"/>
    <dbReference type="STRING" id="796604.A0A2X0M5Y6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15535">
        <property type="entry name" value="PHD1_Rco1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15534">
        <property type="entry name" value="PHD2_PHF12_Rco1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052819">
        <property type="entry name" value="Chromatin_regulatory_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47636">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47636:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="323"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="472"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="97"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="645"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="97"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY40855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="742" mass="78514" checksum="AF11AE47703138CE" modified="2018-09-12" version="1">MEGFADNVLAYHDVLPPGPHRAAPSSGGGGSALAPQPSAAPPSAQTGAAHVTANGARPLTGLGLGQGESHAEAEDTGRTPRGDGALRAAVASIANYDSSTARASSMDRSAASSSTSNSNSTSTDGDGGSSSVASGHLPPSSDHHSGVPVAQERVRSRLVASTSSSSMLLHHNGDMEVDDDASSSAPPTPFLAGLTETASGDATGDDAVVSSSGTATPVLNPTRELEEQEIALFGAASVEDSLPPPPRELAGKGKVGGWGSTGASAGLGLGDGIIKPGSKRAQKSIKISAGSATSVKGPKILARRAAVSAHKAFSGEEAQLPNNDYCDACLGKGHFLCCDGGCLRSFHFTCLDPPLDVDQVPDEAWYCKACRAAKRRCGPSRATHTKESRDGDVWKESSTRFFRELIHKIDCENPKVFSLGPDIKSLYKNIATGAVGEYIDTTEHRPPSKITGRAVGQEERDGYKLRDKTGKTLICYHCNETASIAKQRRIISCDFCDQHWHLDCLDPPLVGMPPPTRKWMCPAHTQHVLVSRVVTFHLVESVTDALIHYILTYQPKKRIPRSTTTIPVQSRDSTNNGDILVIPKREPRLLDDDRYEEITVNRVRYQVPEETIILDFWGKAGALQASLKASLALKALDKSPAEHGLLATNRHSSPDMDVLSNESDDDALDRRHTSHGPRSSSSLSALDGLALLAEVRFADLQASKEEDAAMGDGVQNWVGSTKEKINGSGGDITHTIAGSETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M7S0</accession>
    <name>A0A2X0M7S0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C007g04690 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C007g04690</name>
        <name evidence="2" type="ORF">BQ5605_C007G04690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY62439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M7S0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY62439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="298" mass="32275" checksum="87D78775C4C17A21" modified="2018-09-12" version="1">MAPVALIMSTGEMSQLLQNKGGRPPIALQEQSSPEGYASEVDSEVDEDEDSLQVLAALVPVPSKSSISSPSAVSGLLISPKSRSRDSDEDSADEGYYGVDDDNSDEKLIDNIFSALLLARNDKKILDRHTYEPSRQDKELSNTTREAIFSNMILTTAEHNELRLRPLVLNCRKCCNRSLSARIVDDTSLVARISTTAQKDYSKSNKDASAPASSDSNSNVAAIGVDESALMTYTFPYSRTMPRFPWIIDSGAKVHCVGVVNQSIDSLVADYRSTLVIAHATASVAPVEPEPPPGLLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M859</accession>
    <name>A0A2X0M859_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C007g04887 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C007g04887</name>
        <name evidence="4" type="ORF">BQ5605_C007G04887</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY64241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M859"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retroviral polymerase SH3-like" evidence="3">
        <location>
            <begin position="2"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="240"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY64241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="712" mass="77597" checksum="BC4B55E0D254BF4C" modified="2018-09-12" version="1">MAIPLIFVGLDDHSKAYRLFHPTTRKVLLSRNVLFRESEFPASTPTPALFSPANPLPDVVASRPDQADPPQPLLPAPPRSPVPRAEQLIPAPDASDQGSPALARNVPDQALPAPFASDQGGAPDQGSPDSAFSTPCPSPRLRPSSYDFSALCLAPEFSDDVDDALHSPAPVCYLADAAAALLDTSTVDPAELVAPARDPPHWRAAMASPQADEWRLAARDEFDSLSRDFSAFTPIDQSLVPADAKIIGSRFVFRTKRDQFGKVKSYKGRLVARGDSQRSGIDFDETFAPVAKFTSIRALLALSAARGYHVHQADIDKAYLHGKLDKPLYMRVPEGIALPGQVLQLHRSLYGLRQAGRIWNDEIDSTLLGLGYIATESDHCVYVKTVGDVHHYIVLYVDDLLMIGPSLPEIERTLQGLERCYGVKRLGEAEYVLGIQIRRSSDGSITLSQEQYLKDILARFGMSNAHPVATPMISDLHLEIETNPTPFADRTRYLQAVGSLMYASTGTRPDLAYAVGYLARFSRSPSEAAWGAIKHVFRYLAGTLSHGLCYSHGDSAPVIGYSDCNWGACVLSSKSTMGYAFLYAGGAISWSSRLQSRVADSTCDAEYLALSHAGKEAVFLRQLFGELGLPSSAPTLVLGDNQGANALTRNPVFHARTRHIRLREHFVRDMVALGDVAVQYINTADMTADIFTKALARDLFARHRGRLGICSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M940</accession>
    <name>A0A2X0M940_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C001g00968 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C001g00968</name>
        <name evidence="4" type="ORF">BQ5605_C001G00968</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY51134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M940"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF515">
        <property type="entry name" value="GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="46"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY51134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="703" mass="77194" checksum="DC47FA6B8AC5679C" modified="2018-09-12" version="1">MRPARSARLSPEPSGEWIPHKSDSSAVLQDFVAMSKTQYGGQGITTLRTDRGGEFVNHRLRDWLAARGIFHELSTAYEHGQMGVQERSWQTIFNSVCAWLHRLGLPPALWDEAVHAAIYVINLLPLSPLQQCTPDSVLHEPSDPVTDTRRPRLDRVKTWGCAAHVPLAPKQRPNKLAPRSRLCYFVFESSQARFFEDRFFPAAVSPAMPAIPVAVGLSYPPAPLGIGSAAAPPVAEAPAVAPAAAAPPPVPPALAFLNPGPANAPPDGWLEVVVRRKRSGTLHRRPPDYLGFAHAAQHWEFADHAAIQFDDFDKGDPDTQMYSFEEVSALLAKINSDDTPLVQAALAGPFRDYWLAAMSVEEGALAAKNAFSKLVRPPPGAIVIGSMWVLLVKRNAEGQIVKYKARLVARGDMQRRRGGKTGAAIVNQGHFVDAILEEHHMANASPRPTPLAAPSTLRNRADSSFDPALIPYRAIVGKLLYLSGTTRPDIAFAVSKAARFCNDFTAEHWEALKHILRYLVGTRNFGIRYQKSFQPMSAILEGFVDADHGADPVTRRSVSGYVFMCAGGAISWIAKRQTLVTLSSTKAEYVAMSYAACEGIWLRRLLADLGFEQTTPTRLRGDITLAKHPAFHARTKHIGIHFHFIRDHIAEGTIEMVWVPTGTMAADVLTKGLGTQKHYQFVHAMGLIDSSREGASWRVVNED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M9H2</accession>
    <name>A0A2X0M9H2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C011g06345</name>
        <name evidence="12" type="ORF">BQ5605_C011G06345</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY11981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M9H2"/>
    <dbReference type="STRING" id="796604.A0A2X0M9H2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16104">
        <property type="entry name" value="Ubl_USP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044635">
        <property type="entry name" value="UBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982:SF1">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="9">
        <location>
            <begin position="5"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="10">
        <location>
            <begin position="106"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="11">
        <location>
            <begin position="799"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="383"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1023"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="383"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1037"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1055"/>
            <end position="1074"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY11981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1264" mass="139526" checksum="4C3D3360E02692C9" modified="2018-09-12" version="1">MPSPLDITIKHAGKSYPITLDLDQPGSHFKQQIFERTGVEPSKVKVVVKGGMLKDDADLKKLGLKAGQTIMVIGAASPLPPPPTEKIVFMEDMTDIELAQAVATPIGLQNLGNTCYLNSTVQVLRAIPELQTALDAHPGSSSSAASESSLTASLRDLYKNMSSTQEDFPPVVFLQMLRQFAPQFAETSRLGGGGFAQQDAQEAWASIVQAVKTSLGSSGSGFVDQYMMGEMTKTLKSPEALGEEPTVSKERFLEIKCPISASTTYMMTGINDSLNQDIEKTSPTLSRQAVYHETSRISRLPSYLTINFVRFYWRREIGKKTKIMKRVSFPHDLDVINLLTDDLKSKVKGMNVKLKEVDKDRRERAKVRRRAKKVEEAIKAPMPSTTTAAVAAPANPSDDPPEAMAVDDATPSTTKAGELVDETSKRHEEAQLLNSLVDPSLKVDKGANVSGLYELVGIVSHKGASADGGHYVGWTRADAMDRSKNPDHKGKGKEVDVADVEDPDKVEWYKFDDEKVTTVKREKITLLEGGREDHCAYILIYRSKSLETPESPAGGAFFFFDILRTQNPENRRGASQKIDILGRNTPYGIALGPFAFASKRASRCSRLNKSLAIFANHFSSVAHDEMIPCLFLDENQDYYLHDDDFDRLSPLTNMTVAELLAFDVAPADASLHIELSKDEPTQYSILPYPTLQTRDAFLATDALINARKQGYRSLAVGSTCLPLGADRLWSEYDRATDVQSWALRAQRWMDKIIVINEIDRNRIAVARRIPNGLQWQEQDGLLPLPLLASGTSLVYLLRLLSQQLAYSRLYPGHDWLGEAAVNLSIESVLRAGRVQNPDFETSYGLIPSTVISLVMARPPDSDPHSVFKACFFGPPNQYRNLIELGDCMRNTPTSKSIWFLPLFSDSHWVLARINMHKRTWSVINSLSATPITAATRTAVLTLFKFLKLDIRNEFPHTPKAEQQEDSYSCGPATINAVETEVLGIGSFNAARAHMSRLRQFCRLSSLVGAVEDPKEIESIVATGAKSKAKSGRGSAAGTLSSKSTSAESGKAATIKPTNQRVASSSKNPPTSRLQTTFTKHTTWARDHPPLFRRFAEKVEDLCPGSNVDVNNPKYVRCGCCCVLVPMAALLCKARFQLHLGNKKCVNLQPISNFFRPIASGSTATSPSLGPCPGLTSETAMHYLSPTAAQGGGAPPRRTLCLRLYPKIGKRPMTELERKEVDRLEANEWKWRNNHRAPRIISVNCRKYSARDLCCCRSVSSYVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MBK2</accession>
    <name>A0A2X0MBK2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">dihydroxy-acid dehydratase</fullName>
            <ecNumber evidence="14">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">BQ5605_C004g02609</name>
        <name evidence="20" type="ORF">BQ5605_C004G02609</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:27695"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IlvD/Edd family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14"/>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY65962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MBK2"/>
    <dbReference type="STRING" id="796604.A0A2X0MBK2"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.80:FF:000001">
        <property type="entry name" value="Dihydroxy-acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050165">
        <property type="entry name" value="DHAD_IlvD/Edd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002068">
        <property type="entry name" value="PRK00911.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000:SF5">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="18">
        <location>
            <begin position="62"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="19">
        <location>
            <begin position="414"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="SGY65962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="606" mass="64604" checksum="0382D8D1E0976E26" modified="2018-09-12" version="1">MVGNGPQSPMDSSATKNIKPCHRARSANLNKYSRLFTQDVTNGGAKAMLYATGMTDEQMKLPQIGISSIWFEGNPCNAHLRGLGDKVAKGCELEGLVGLQHSTIGVSDGQTQGNPGMSFSLPSRDLIADAIEMIVTAQSYDGNISIPGCDKNLTILPSAEKPIQMPGCLMAAARHNKPTLIIYGGTIAAGKRTIDCPSMSFKKGEDITIGDAFESYGAWATGRISDAERDDVVKHSCPGAGACGGMFTANTMSTVLEVLGMSLPYSSSIPAEYPEKQQECLRAAKFMRILLEKDLKPRDIMTRQSFLNAITMCMIIGGSTNSVLHLLAIARSADIPLTTDDFVAIANKTPVLCDLKPSGAYVMEDLHKIGGIPSILKYLIKETDLIDGSQMTVTGQTLGQNVEDAQDLDFEKQDVVRPLNKPIKATGHLVILKGNLAPKSAVSKVTGKEGLSFRGPAKCFDDEPSFYPALSKGEIKPGMAVVLRYLGPKGGPGMPEMLGPTGALMGAGLGGSVCLLTDGRFSGASRGFIIGHITPEAAIGGPIALVQDGDMIHIDAVTREITAEVDDKTLEERKKGWKAPAHKHRRGVLYRYARDVKGADEGAYTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MBW5</accession>
    <name>A0A2X0MBW5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C010g06172 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C010g06172</name>
        <name evidence="3" type="ORF">BQ5605_C010G06172</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MBW5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016174771" evidence="2">
        <location>
            <begin position="21"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY14402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="186" mass="20368" checksum="726BB714F573EAE9" modified="2018-09-12" version="1">MLFKVSAALVLAGLSLGASALPSMSTESRAQPSPSSNDKSPYGRTGYIDSPADRKTTTYKVGDKIHFVYNSAPATYFVDVSLMLANGNQSFELANRLTGSSMISNDANARAYFRMPENLKSIATKLLEASQDEHSVKMKSNNCILAYRFEALRSSIWYQLIAKETQNGEYGLVGDLETRQAITISM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MD67</accession>
    <name>A0A2X0MD67_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C004g02877 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C004g02877</name>
        <name evidence="1" type="ORF">BQ5605_C004G02877</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY68316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MD67"/>
    <dbReference type="STRING" id="796604.A0A2X0MD67"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01571">
        <property type="entry name" value="A_thal_Cys_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15907">
        <property type="entry name" value="DUF614 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY68316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="169" mass="19081" checksum="5CB3AB4BCA9D5741" modified="2018-09-12" version="1">MSVGGNRNSRSVEIGLDGYRHWNNDICRCHERPWLACAAYCCPCVIWSLIHSKTEHLVAHGTPHPNPRKVGSWCCIIAFSPICVALPEVLLDYASRAETRKRYGIRGNWAEDFAIALCLPCCSIVQASFSFALRPFAARCEYREIEDEEIALGVEPAPRPTWLRPHNID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MD94</accession>
    <name>A0A2X0MD94_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoserine transaminase</fullName>
            <ecNumber evidence="4">2.6.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C005g03181</name>
        <name evidence="14" type="ORF">BQ5605_C005G03181</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>4-(phosphooxy)-L-threonine + 2-oxoglutarate = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16573"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58452"/>
            <dbReference type="ChEBI" id="CHEBI:58538"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-serine + 2-oxoglutarate = 3-phosphooxypyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:14329"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.52" evidence="4"/>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY72555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MD94"/>
    <dbReference type="STRING" id="796604.A0A2X0MD94"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00197"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004648">
        <property type="term" value="F:O-phospho-L-serine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000010">
        <property type="entry name" value="Phosphoserine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000006">
        <property type="entry name" value="Phosphoserine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00160">
        <property type="entry name" value="SerC_aminotrans_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022278">
        <property type="entry name" value="Pser_aminoTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003764">
        <property type="entry name" value="PRK05355.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247">
        <property type="entry name" value="PHOSPHOSERINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247:SF1">
        <property type="entry name" value="PHOSPHOSERINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000525">
        <property type="entry name" value="SerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0718">Serine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="13">
        <location>
            <begin position="2"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGY72555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="403" mass="43743" checksum="7010AE096A2949DB" modified="2018-09-12" version="1">MNAGPSPLPQSALLQAAQSLLSYSETPGMGIAEISHRSKAFEKVLASANADLKQLLQIPDNYKILWMQGGGLTQFAATVVNLAAWYRIKHQLKSEDPVHGWYAVTGSWSAKALQEAERMGLTTTKIVDGKKNGAGKFKGVPASPDEWTIPAQSDPKTAFVYYCDNETVDGVEFPSAGTPAAFPFDKFDKDIPIVCDMSSNFLSRPVDVSKYGIIYAGAQKNLGPSGATVVIVRDDLIVDLDEAVKYGGGRVPSMLSYKQMAANDSMYNTPPTFTIYVCSLVLRSLLESPPYPLKSETAAPLSPLAQLADAKSSLVYSLLDDETRFYLGTAHAASRSRMNPTFRIKGGEQVEKDFVKLASEKGIMGVGGHRSVGGIRTSIYNAVTLAQVETLVEFMKQFRAERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MDR7</accession>
    <name>A0A2X0MDR7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C009g05554 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C009g05554</name>
        <name evidence="5" type="ORF">BQ5605_C009G05554</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY82232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MDR7"/>
    <dbReference type="STRING" id="796604.A0A2X0MDR7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904868">
        <property type="term" value="P:telomerase catalytic core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014886">
        <property type="entry name" value="La_xRRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045537">
        <property type="entry name" value="Lar7_xRRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19977">
        <property type="entry name" value="xRRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51939">
        <property type="entry name" value="XRRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="XRRM" evidence="4">
        <location>
            <begin position="473"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="215"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="390"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="627"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="395"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="410"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="427"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="637"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="649"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="685"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY82232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="696" mass="77689" checksum="B469A58E7396EE08" modified="2018-09-12" version="1">MFKPRQVANKTGPSTTPNVVPPPTASASLSASSSTSHAPISVDNPPPPPAPIASTSTAPPTVAPRLDPKLSTKEKDRLQTLLSTIESSFSDWGLSTYQRQNGMLQRLRQDPNQNVHLQYVVRLDPIIALTNNQADLQNALRHKTSSVVELDPNDPFQLHVKRTLHYDRLEHLTPSHWDPCILYLEHVPSPTHHSLPLVDLLTQLLRTTIQRIILPPAYDPSHPPSSSDALYSSSSDRPTQSELFDQSRSVAKDKDNEKGKGKGLRLPKSGGTFKGFVFVIVENAEDAQRVLSEWDWDWDAQADKVEQDEVEALEKELESEIEREMGMEVDDQERAGDEQVDLVKVAKKGGMRAITYSRWLEFQAEYLIYQQALEGLKKEGYRSSSRSYYNEYDDREPIPSKDLPPHLRVPSSSSASSTNPNSKTKRPSTNELASSTPHKKPRTSDVPPSAPAPRAGKPLPALDSRAALKLHGAYPLDCVLWVRNLHEKSTKGALRTLFCKLLDRLEEGSGKGCEFVDYEKGLESAKVRFSTPHHAQLVRTHFEQNPTRHTRRDYFSFEKEPMTPPEGMEEQELQDGGVGGLAEGRRLVVAELLKGDLEREYWDKIPEEKRRDARKSAKVEVGIVGKKKVATTGDGVPQSQSQGQGPSEGEEKAREAVGNGDRNDEPGVEGSERNDEESKEEGKEKSKKRKRPSARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MEC2</accession>
    <name>A0A2X0MEC2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C009g05754 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C009g05754</name>
        <name evidence="6" type="ORF">BQ5605_C009G05754</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY85388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MEC2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35371:SF1">
        <property type="entry name" value="BLR7753 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35371">
        <property type="entry name" value="INNER MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY85388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="153" mass="17096" checksum="E622E7D005E6C934" modified="2018-09-12" version="1">MTYNYSYLVGFPGAWLMHMSAHWYAAALTKQSKDMKFFDNRSPRAYLAKVTALEKQTPDQQKYIRAEAANANGAEAIPLFGLAIIAGNMARLPAETMNRFVFTWLGLRALYNVLYIGTNGHKLSFLRSLTFVGAIFSTFNIFIKAGRVLNGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MEJ8</accession>
    <name>A0A2X0MEJ8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C009g05824 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C009g05824</name>
        <name evidence="5" type="ORF">BQ5605_C009G05824</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY86518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="506"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="267"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="773"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1518"/>
            <end position="1623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="780"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="801"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="828"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1573"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1610"/>
            <end position="1621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY86518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2017" mass="219426" checksum="F01410DE487F17B9" modified="2018-09-12" version="1">MSDSDVPKPTTLTVPPPRPPTQITAFAASDLLRDADGYQDWVLTLCSRMPSDVIDYLKSGVPPTSWPPAYVPLWDHYARASICAAVDPRLVLPGLSQYFGDTHSGHKIWAALRTRYGAVSAVDLLPVISRLFSPDLMPDTADAFLQFRDRFENDSRLLNDSDVTTDSLLASHLLARMPPSLSAWRTTFVNSQGTSRTLPHAAEILDRIYREIKARPIDPLAAATVTATSPQRTPPSPCPNPTCRKMHWLRDCPDTTWAAAFRARKAASGTTSRAHKKGSRTIASPAVTSPTDTERPEPTTFTACLLATPSAFPKSAWLLDSGANRHMANDSTLFSSLRPFTGPHVAGVAGSLPSTGCGSVRLSTSAGPVVATDVLLVPSLPCNLLSVRRLDRLGFTVSFGSGHAAIRNSSGTVVATARAIANDLYALNVAPSTCMPNALLATPHRVSLLTLHRRLAHLPVAQLKNVVQKGLVTGVDWVYSEEEFRSFHCNACLASKAHALPFARSKSIAPGRLALIHVDVAQMPRASFGGHRYMLVIVDDYSRKQWCLLLTYKSDVFHRLRDWILEVENATGDRVKTIRSDNGGEFTLRTFVDFCVAKGIRRELTIPYTPQQNGRVERTNRTIKEGILALLYSAGADTRLWAEAAKYFVHCKNLLPHAGIHGEVPDTRWYGMAPDVSSLRTFGCRAWHCLPSVKRTDLDPKAVPLIFVGLDDHAKAYRLFDPATRKILLSRNVVFRESEFPALQPAANTTTGATPLPVAAEVYPDQVDHSEPLLVASPRSPAPRAAPPAAPPGPAPVASDQGPSPASDQGSPTASDQGSSDSAISTPCPSPRPVVPRPLPAPPSPARSESPDPIDLLPRSSDLASFCLAPEFPDDLDDALHSPPPVAYLASGAAALLNNAPPDSTELIAPARDPPHWRAAMATPQADEWRLAAQAEFDSLSRDFSAFTPIDESLVPADAKILGSRFVFRTKRDQHGQVKSYKGRLVARGDSQRSGIDFDETFAPVAKFTSIRALLALAAAHGYHVHQADIDKAYLHGKLDKPLYIRVPDGIYMPGKVLQLHRSLYGLRQAGRIWNDEIDSALSALGYAATESDHCVYVRTAGDERHYIALYVDDLLMISPSLPEIERTLQGLEQRYGVKRLGEAEYILGIQIRRSDDGSITLSQEQYLKDVLARFGMSDAHPVATPMQPDLRLEVELQPTPFPDRTRYLQAIGSLMYASTGTRPDLAYTVGYLARFSRAPSTAAWGAIKHAFRYVAGTLSHGLRFAHGASPPLVGYSDCNWGACLSSSKSTMGYNFIYAGAAVSWSSRLQSRVADSTCDAEYLGLSHAGKEAIFLRQLFGELGLSSSEPVLIYGDNQGANALTKNPVFHARTRHIRLREHFVRDMVSLGDIVIQYITTSEMTADIFTKALSRDLFARHRGRLGAGQLAPRFSLSCSSNFIGLVSLVCAKQLHWSGLLGPLIRDSPPLEQVRNVVFRESEFPALRPATDVRAEPIPLPVTVDAYPDQVDPLEPSLVASPRSLAPRAEPPRPVPAAPDQGPHRPAPAREVPDQDSLAPPAPDQGSPARELPDPESPASSASDQGSSDSAISTPCPSPRPVASRALPAPPSPARSDSPDPIDLLPRPRDVASLCQAQGFPDDVDDALHSPSAVAYLASGAAALIETSPVDPAELIAPARDPPHWRAAMATPQADEWRLAARDEFDSLLRDFSAFTPIDESLVPADAKVLGSRFVFRTKRDQHGQVKSYKGRLVARGDSQRSGIDFDETFAPVAKFTSIRALLALAAAHGYHVHQADIDKAYLHGKLDAPLYICVPDGIYMPGKVLQLHRSLYGLRQAGRIWNDEIDSALSALGYVATGSDHCVYVRTTGDVHHYIALYVDDLLMISPSLPEIERTLQGLEQRYGVKRLGEAEYVLGIQIRRSPDGSISLSQEQYLKDVLARFGMSDAHPVATPMPPDLRLEVELQPTPFPDRTRYLQAIGSLMYASTGTRPDLAYTVGYLARFSHSPSAAAWGAVKHAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MEP4</accession>
    <name>A0A2X0MEP4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Adenylyl cyclase-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C005g03220</name>
        <name evidence="7" type="ORF">BQ5605_C005G03220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">The N-terminal domain binds to adenylyl cyclase, thereby enabling adenylyl cyclase to be activated by upstream regulatory signals, such as Ras. The C-terminal domain is required for normal cellular morphology and growth control.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the CAP family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY72854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MEP4"/>
    <dbReference type="STRING" id="796604.A0A2X0MEP4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008179">
        <property type="term" value="F:adenylate cyclase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019933">
        <property type="term" value="P:cAMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.330:FF:000001">
        <property type="entry name" value="Adenylyl cyclase-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.330">
        <property type="entry name" value="Adenylate cyclase-associated CAP, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001837">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013912">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013992">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036223">
        <property type="entry name" value="CAP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018106">
        <property type="entry name" value="CAP_CS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053950">
        <property type="entry name" value="CAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036222">
        <property type="entry name" value="CAP_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652:SF0">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08603">
        <property type="entry name" value="CAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21938">
        <property type="entry name" value="CAP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01213">
        <property type="entry name" value="CAP_N-CM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69340">
        <property type="entry name" value="C-terminal domain of adenylylcyclase associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101278">
        <property type="entry name" value="N-terminal domain of adenylylcyclase associated protein, CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01088">
        <property type="entry name" value="CAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="6">
        <location>
            <begin position="369"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="281"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="287"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00054756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00072052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY72854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="539" mass="55203" checksum="4A85095213E94C64" modified="2018-09-12" version="1">MNTASAQGTHAGIPATGVGSLNTLLRRLEAATARLEDIAVTSAASGGPHFNVASGASAVVPSTLAGAGAGTIAGGVAAPGGSSLAAAAGPAVEVPRSVAAFDEEVLRGALAKYLELSKELGGLIADQSKHVQAAFNAQRAFILMASACTKIQASDPSYMSLLKPTQQALMSTIEIKDKNRASPDANQLTVVAEGIPALGWVTLDSKPGPHVGEYKDSADFWVNRIVKAFKDTNPKQVEWARSFSATLDALRKYVMANHTTGLTWNPKGIDPAKYLASPAASAAVGGAPPPPPPPPAPPAAPPALKAPAQAAAAASGDMSGVFAALNKGENITSSLKKVDKSEMTHKNPELRAGGVVSAVGAAGKGPTKPPKPSAIAQKKPPILALEGNKWLVENYESDPHITVTETSIQQTVNVFNCKASVLQVKGKVNAISIVNSPKLSVLLESTVSALSISSSPGFTVQILGKVPTILIDGTDGGMIYLSKESLGTEIITAKTSALNISLPVEGEDDGVFEERAVPEQLKTVVVGGKLVTTVVEHSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MF73</accession>
    <name>A0A2X0MF73_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C008g04992 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C008g04992</name>
        <name evidence="1" type="ORF">BQ5605_C008G04992</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY78928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MF73"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY78928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="109" mass="12564" checksum="C9A9128425FAE3C0" modified="2018-09-12" version="1">MHPSYVMPEDSLGTHQAAEESGTSVGEVIIPFRTVLGFELIGCWRKMRCHYTGIFLFGFGMQWWTSGQRFFRVSPTLKRSRDSSGLRVVLFGLEHVNRFDAYALWSEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIA3</accession>
    <name>A0A2X0MIA3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C009g05781 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C009g05781</name>
        <name evidence="3" type="ORF">BQ5605_C009G05781</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY85820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIA3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="18"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY85820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="392" mass="44445" checksum="0E058DE17D4FBEDF" modified="2018-09-12" version="1">MRYPLRTISTQSNTPTASSTNVRRKWKADHHIILTRLVKGYQKAGQEVDWEEVGRQIGRSATATISKWKRLVQTKSVPKENAKLRGVASKFAPAVLDPTLPSAASSGATGSRKKARRRTEKERQTSLKETKRTIKSITSDQNTSSKTTTSKRIKKREEVQDQGGEDEEREQKSVAIKTPVLSAESEERKPVHEPFEAESANFFKEPFVPMSSPTFRPWTPSEDFSLVYSVILRGEHSWDVVMNERAPETQHHPPYASDQARLLPSLRECGRSVDEVVARWFESWRARVAEHGSEWSQVTDNHKDYRLMSREQSIEPSLAPRRSFQSYESCVFSNTPTLSQAPVVLYHTAQAQLPAREEAMYPSPRPIDMYPLSSASYYPISRSPLSLPPQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIK0</accession>
    <name>A0A2X0MIK0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C009g05732 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C009g05732</name>
        <name evidence="2" type="ORF">BQ5605_C009G05732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY84997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIK0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY84997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="280" mass="30631" checksum="CA5B8C1CAE132167" modified="2018-09-12" version="1">MMPAGDETATSAAAILQQRLAALRFSNPSSSSPFPSGTLSTIKTGDGLAKNDEEEDENLSQLLASLDVPDDTGDDESDDDTDFLNDGIDVPIQVKNVDEQVTHYLKTASQLPSTATLPPLSSSTSQTKLEATLSSYETLAPNFVSPIEVSFFTPPSTNLSGPSGGIRGDEEEALMARLRDELSVERAVQSREGNVEDVWERRLSKMKEFRPITDPDKERECLERAKGLGEGPALEGVEELQRRRKSRENKGRRKRGSGSEEDTDSEEDTESESDEDSDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIX7</accession>
    <name>A0A2X0MIX7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C028g10572 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C028g10572</name>
        <name evidence="1" type="ORF">BQ5605_C028G10572</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000080">
        <property type="protein sequence ID" value="SGZ13478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIX7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ13478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="47" mass="4985" checksum="9CFAFB211E4015CA" modified="2018-09-12" version="1">MGCGGSKAAEQDYHTAVQATKKEEEKAVAKRIYGAGRGDVQFEVGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJS4</accession>
    <name>A0A2X0MJS4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C010g06104 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C010g06104</name>
        <name evidence="4" type="ORF">BQ5605_C010G06104</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJS4"/>
    <dbReference type="STRING" id="796604.A0A2X0MJS4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051498">
        <property type="entry name" value="Phosducin-like_chap/apop_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024253">
        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809:SF3">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02114">
        <property type="entry name" value="Phosducin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosducin" evidence="3">
        <location>
            <begin position="54"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="16"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="251"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="284"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY14214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="332" mass="36550" checksum="5AC5FE105B1C182C" modified="2018-09-12" version="1">MPAINYEEDTEFNEALRKHGIIPPKATDGTSSRSPSPPPAPTSPSLSDVDDLDELDIDRDDSLSRDVVEKYRAERMAKMKVAEQRRKFGRVYPIGKVDYTREVTEASKAIIEGEPEGYGTGVVCVLYKDSLPACKILLPLLDQLSLLYPSSKFVKIVSDHCIENYPDKNCPTMIVYRNGEMMGQIVGLGAMGNEKCKLVGEGSASTAIEHLNYLWGSDSHRTIHLTDVERILFAFRGIDFHLKIGNEARGSQFSSKTSSAAAPLEKKTANTSSNKSRTGRDEVGSDEDGQADEDSDEDDQTFVGGGRRSGIRNGTRGRKKGEKSDDDDDFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKH5</accession>
    <name>A0A2X0MKH5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C021g09383 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C021g09383</name>
        <name evidence="3" type="ORF">BQ5605_C021G09383</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000083">
        <property type="protein sequence ID" value="SGZ21576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MKH5"/>
    <dbReference type="STRING" id="796604.A0A2X0MKH5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018822">
        <property type="entry name" value="UPF0646"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10336">
        <property type="entry name" value="DUF2420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="67"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="188"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="304"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="386"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="617"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="803"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="853"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="560"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="649"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="314"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="386"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="404"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="625"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ21576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="880" mass="93307" checksum="40D8B49C4BAC6FF3" modified="2018-09-12" version="1">MNLDDAMLDAAVEVPEAEMKIDYGEDDDGVVEGGEDDALMQDEAQTVAVGTAAGGAAATGGDGMLMLLDDSLAPTPTPAMDADDEPEAANDNGLEPISLPPNTLFHSPPPSSSPVSTSTSTSTSSSSSSGPSYTSIAPPTLPFHPGFSSPPLINVSSNELQLSALGHSAAAVTPSRLSSAPFSLGMDHPAPIVSPTPGFDPAQLTANDHETSDARSLLTPLADGTQQSLLVPQRALASQHQHSSDDVQTQDQAIEALGPGTTRIVQEQQLRQQSEDDPDVDGVAKQENEVIIRQGLDGHIIVETEQRNSVPPRSASASASNASGSTSEGDDEQQQQRNGGQVRQINSVKVVEAVGASSGLLKRPLIDKAVLEFFGLGDEAALQISEDDDAEEESVADGETADAPPRPAPPPLAPTVLLQFGEDRYTIFRAAPVVEDGQDAEDLPILFGERKEHHLYYEQIEALFEALHASLPGLESTQAEYSLEIDGLGIVLQEDNVYTREVSLYDFHRLHSGCGLPGRMLVKLAECEGPRFPTGFNALMQHIMRVADGREDSLAAGGEEEEKEEAYEEAVEEVEAGEAEVEVEAEAEAEAEAEAEAEAEAEAVAVAVAEVVSKEAEAAAEGSSYDEREWHETTEGGEEYGEAEERSEVYEAAEDEEAEEEAYEELNAEDLAAVVEGAQEDYVLAQDQVEEANGEAMTATGEEINGHSVNGHKAVAAEKRIPKSIKALRSEPLELSYDTPESTGFESPAIPLDKREAVVEAATAPTEQNGNGTTEASVVGKEVLNTEGTFNVCSEVVIDYDETPDAPTLQDGAKRSRSSLTEGDDVEAVEEKDTSGSSFTMFYHGFGANRSAISHLDDSKRQRRSTSPSNQVVEAPKGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKM0</accession>
    <name>A0A2X0MKM0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C022g09434 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C022g09434</name>
        <name evidence="6" type="ORF">BQ5605_C022G09434</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MKM0"/>
    <dbReference type="STRING" id="796604.A0A2X0MKM0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF160">
        <property type="entry name" value="NODULIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGZ22134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="491" mass="51920" checksum="A945F1041DA7F3C5" modified="2018-09-12" version="1">MMSANSGGYLAGPFTGLLVDARGPRLTLLLGSVGVFLGYYTLKAFYDSGADGLYLQFGLIPLVLCQGLVGAGSSSSYAGFTNGCAKAFSHQRRATVLSICIACLGLSAFVYSTLAASYIGTHLIPGIDATSSFLCLLAFGTGGSIFLASFAIQPRSFVHNYAEVPSSIDAVETLSGADALGASESRLSVPELRPGSPDESSITLLPRDIVFTIDGTEVDRARSELPLASIRVPETNLSGKALLCSINFWALFLYLGVLCGCGLMYINNVGTILFSLPSTSFASSAVPLKEAQHRLVALLSITNCLGRLCYGPVTDYVTRNYRIDRTWFTIPIAATFVLANLWVGSKSSRDGFLGLEGPTALVGFAYGSMAGSTPVLCIDWFGLASFSTNLGLLGTSPAIFGNILNLLFGAIYDSHSHPAPIFPHTIEHGAPSAEALPEATGPLCSLGQACFHEAFQVTTALSCFALGLAVWMGMRRVRLVREERKALGEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKU4</accession>
    <name>A0A2X0MKU4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BQ5605_C033g11215 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C033g11215</name>
        <name evidence="11" type="ORF">BQ5605_C033G11215</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000066">
        <property type="protein sequence ID" value="SGZ02538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MKU4"/>
    <dbReference type="STRING" id="796604.A0A2X0MKU4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019185">
        <property type="entry name" value="Integral_membrane_SYS1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952:SF0">
        <property type="entry name" value="PROTEIN SYS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09801">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="240"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="368"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="278"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGZ02538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="402" mass="42971" checksum="B4F53F3ECC752F21" modified="2018-09-12" version="1">MAPAARLTLPAGTRLPTFHIAPPHFRVRGWDPLLIIAQIVTLQTLHYLTLALLLPPLLSRFASSSLLGYEGGPSSVSVVMDWREFIGRPTTSLTTRRSLPAGLVGLDVFQAVSTSGAWGLKALIAKGDGKAVHVGVKEITEGLVRVLEYDQFRGWVVAFAWCITAMIDVFYLYHFVRRPTHILDSSLTLLFNHLILTTYYSSQFPTSFFFYFILIGSSVVQIVLAEQMCVRREMKEGFSFDENGSNGSASPDVNMNGGGGGAKLGNNNVNGGSNGKGSTDSATTPLLRNNFSPNPAEPSRRTSSPNSITKLSDEQHEMSVFSSPSSKTPQSHSHTKSFGAGVGTGTGTGKKLHSKHLSLTTAVQSILGAGSGGGGGGMVSSPISMKGGNNYDRVSSKDRDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-03-27" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLE4</accession>
    <name>A0A2X0MLE4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C030g10796 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C030g10796</name>
        <name evidence="7" type="ORF">BQ5605_C030G10796</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GILT family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000069">
        <property type="protein sequence ID" value="SGZ08472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MLE4"/>
    <dbReference type="STRING" id="796604.A0A2X0MLE4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016671">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004911">
        <property type="entry name" value="Interferon-induced_GILT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234">
        <property type="entry name" value="GAMMA-INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234:SF8">
        <property type="entry name" value="GAMMA-INTERFERON-INDUCIBLE LYSOSOMAL THIOL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03227">
        <property type="entry name" value="GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016176511" evidence="6">
        <location>
            <begin position="26"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGZ08472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="265" mass="29270" checksum="996E76A69D4B38F7" modified="2018-09-12" version="1">MVLRPHSPHAALSLLVLLLVSLALATPIVEREGHATSIAVAASHGASQTAFKAQIDPKKDKKVPIRLAVMSRCPDAELCESVFDRVLDKVGPLVDIKLLYIGELDTKDGKVTCKHGPSECTGNIQQLCAEKHWKVVNGSDNPWATWWNFVQCQNYNGLSRIGTDRLAQTCASVVGKRWSGDVEHCAISSEGRQLLRDSVQVTKTLQLVKSCSIVIDGKLVCVRDARWIDCDEGHEVGDFVNLVNKAWKRLNEREESSDSALEDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MM12</accession>
    <name>A0A2X0MM12_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C012g06689 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">BQ5605_C020g09038 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C020g09038</name>
        <name evidence="2" type="synonym">BQ5605_C012g06689</name>
        <name evidence="2" type="ORF">BQ5605_C012G06689</name>
        <name evidence="3" type="ORF">BQ5605_C020G09038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY15882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000082">
        <property type="protein sequence ID" value="SGZ16581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MM12"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY15882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ16581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="72" mass="7474" checksum="4D41AC1AFB9B285C" modified="2018-09-12" version="1">MDGPPAEDVAGDEIGASDGDDEGLVSVELSKDPPVYPGATSTALMAESSRGDETSMCADLTSVMLSRLLKQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MM21</accession>
    <name>A0A2X0MM21_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="26">BQ5605_C020g09048 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">BQ5605_C020g09048</name>
        <name evidence="26" type="ORF">BQ5605_C020G09048</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000082">
        <property type="protein sequence ID" value="SGZ16642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MM21"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <keyword evidence="22" id="KW-0862">Zinc</keyword>
    <keyword evidence="22" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="24">
        <location>
            <begin position="296"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="25">
        <location>
            <begin position="545"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="802"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="310"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="802"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="SGZ16642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="895" mass="97884" checksum="93E077EA56CBE19D" modified="2018-09-12" version="1">MDSSPASPLAPRDPSSPESSIGEQIATLQAQLAALQASQPAAAAAAATPAVTAVPGNAATASKVVFPKHARLDGPKSFTNWLRQLRLALPNQVRGYVLDGVMPLTWTADQLAARDDAAREIIVGSINSANVSATLDAIPSDDLSAPRIFAALKARFAPDDATRTLELFARLWDFRKMPASVEAYDTWLREYMSIAQEIRDTKTSLNDVLATHVLAMVPSCLDSFRLTFTDEQRHRRDLPELTTLTDRIHIQLRSAGLSTSHSAMLATSSPCPACRAPGHRLRDCTSRAKHPPTGPCRRCHKKGHWALDCKNRGEQARRSDDTQDDTSSSAALQPNVGYFASCLFARRQLPTDAFVVDSGATTHMVADRSLFTTYRQTAHTKIGGIAGGITAIGMGDVAFVAKTGHPITLRGVLHTPGLHVNLLSVARLCDTDRVRLAFTSDGIDIAKDGQAIAHGTRVNDGLYLLDADHTKCQQLAFLSRSESTVPLITLHRCLGHLAPSSIQKMIAAGLLDGFGAGYSDKDVEEFVCNACLGSKGHRLPFPDSESHSPERLGLVHSDVLSFPTPSLTGKRYLVTFLDDHSRKLWAYAIDHKSDVFPTFQTWLAEVELETDARLRILRTDNGGEYRSNAFTEFCQSRGIRRQYSIPYTPQQNGRAERVNLSIVEGVLALLADSHLPATFWDEAAAYFVYCKNRCSHSALAKQTPQFVWNGQRTTTTVLHPFGCAAWLTVAPDLCSKLDPKAARVIFTGYDLASKAFRFFDHSTNKVVLGRNATFLDDDFPGLPVNMPVDADDTERQFVIPADAPAPDTADTHAPAATPAPAVKTRTPLPQAPPDPLDAQPPDFSTYREPASAEESPDELDLIGRHSRNESPDEIDFLARHHRAFIVMLSRLLKRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MMS2</accession>
    <name>A0A2X0MMS2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C003g02097 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C003g02097</name>
        <name evidence="8" type="ORF">BQ5605_C003G02097</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY38882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MMS2"/>
    <dbReference type="STRING" id="796604.A0A2X0MMS2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000721">
        <property type="term" value="F:(R,R)-butanediol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034079">
        <property type="term" value="P:butanediol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08233">
        <property type="entry name" value="butanediol_DH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF23">
        <property type="entry name" value="(R,R)-BUTANEDIOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="14"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY38882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="380" mass="40176" checksum="BF6B9362E85C2FCD" modified="2018-09-12" version="1">MSNEATNKVVNYYGKRDIRVEENPMPVPGEGQVLIKLAWCGICGTDLHEYTGKSSTSFAYGPILCPTAGTAHGITGEKLPICLGHEFSGVISKVGPGVKGEWRKGDRVIVEPTISCFKCYACKHNFRNACSSLGFVGLSGYGGGLAEYTVAGEGFLHKLPDNVSLQHGAMVEPLAVAMHAVQMSGATKGCTALVCGAGPIGCFVTKVLIAMGASTCSKVIVSEPSGSRRKMATHAGAHHAISPREDDVVSKCRELTGGDDVGVDVSFECAGVEASLTAAIAALRPRGTCLNVAIWSTKPQIDMNALVLGEKTLRAVICYESNHKPAIETLSSGKISLDGFVTGTASLDDILEKGFHELINNNEQREFISLQPRTQMVEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNX8</accession>
    <name>A0A2X0MNX8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">S-methyl-5'-thioadenosine phosphorylase</fullName>
            <ecNumber evidence="5">2.4.2.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">5'-methylthioadenosine phosphorylase</fullName>
            <shortName evidence="5">MTA phosphorylase</shortName>
            <shortName evidence="5">MTAP</shortName>
            <shortName evidence="5">MTAPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C021g09248</name>
        <name evidence="7" type="ORF">BQ5605_C021G09248</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>S-methyl-5'-thioadenosine + phosphate = 5-(methylsulfanyl)-alpha-D-ribose 1-phosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.28" evidence="5"/>
    <dbReference type="EMBL" id="FQNC01000083">
        <property type="protein sequence ID" value="SGZ20126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MNX8"/>
    <dbReference type="STRING" id="796604.A0A2X0MNX8"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1580:FF:000008">
        <property type="entry name" value="S-methyl-5'-thioadenosine phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01963">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018099">
        <property type="entry name" value="Purine_phosphorylase-2_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679:SF2">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01240">
        <property type="entry name" value="PNP_MTAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="6">
        <location>
            <begin position="16"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="71"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="104"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="240"/>
            <end position="242"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="5">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="5">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGZ20126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="329" mass="36147" checksum="D3D44FF4B9732A80" modified="2018-09-12" version="1">MVYANYPKLMENPPLVGVIGGSGLYKLDNFTIQQTIDVDTPWGKPSSPITIATLSRPDQPGQDVSVAFIARHSPTHSIMPSHVPARANIAALKHLGVQAIVAFSAVGSLREEVRPGDLVVPDQIIDRTKGIRPSTFFDSSLVGHAMFGEPFSVALSQFLIPHIEAAIDSFSSNVQDGDSRPRLHSEKTLIVMEGPQFSTRAESNVYRMWGGDIINMSTIPEAKLAREAELNYALVCTSTDYDAWRVGHAPVTVEEVMKILSSNASLSKHITAEILGKVHDALSNGEIESARGGMKWSLMTRHDFVKQEDLDKYRYILPEYFGEEGEAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQ36</accession>
    <name>A0A2X0MQ36_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C025g10035 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C025g10035</name>
        <name evidence="8" type="ORF">BQ5605_C025G10035</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000087">
        <property type="protein sequence ID" value="SGZ27041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQ36"/>
    <dbReference type="STRING" id="796604.A0A2X0MQ36"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002307">
        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000002">
        <property type="entry name" value="guanine nucleotide-binding protein G(Q) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF302">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-5 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="40"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="147"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="172"/>
            <end position="178"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="197"/>
            <end position="201"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="270"/>
            <end position="273"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGZ27041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="354" mass="40152" checksum="FACB4AD7E944DDE5" modified="2018-09-12" version="1">MGCGGSKEDSSAKQRNEAIDAQLKKDRMMMSKMLLLGAGESGKSTILKQMKLIHQGTYSDKERESYKEIIYSNTVQSMHVILDAMDAMGIPLSSSSSARYSEVIMTQPHQIEADYLDTAVTEAIMELWKDAGVQECFGRSREYQLNDSAQYYFDSIARIGSRNYMPSDQDVLRSRVKTTGITETNFEIGELKYRMFDVGGQRSERKKWIHCFENVTAIVFLVAISEYDQMLYEDVVVAESINRMQEALVLFDSICNSRWFVRTSIILFLNKIDLFREKLPRSPVASFFPDYTGGADLQAACDYFSSRFVGLNQSSAKQIYTHFTCATDTNQIKFVLSAVNDIVIQVNLRDCGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQD1</accession>
    <name>A0A2X0MQD1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C042g12006 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C042g12006</name>
        <name evidence="2" type="ORF">BQ5605_C042G12006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000116">
        <property type="protein sequence ID" value="SGZ31802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQD1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="1">
        <location>
            <begin position="6"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ31802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="356" mass="38621" checksum="2A2F5A6626637049" modified="2018-09-12" version="1">MQRAEVGVGRAHDGSVDVTARSDGVEQHLVDLLHRGLKVGFDDAVELECLARRKLERVVTSAVGDLVNGKPLRRGAHASGQAHADHERVGGLEAGGLAFVADISVVLLVDAVELGQLTIGFGERTRRRVLETFLDRASEVVGRNLDVLVCDGLELGFVRLEAINAKRLPHGRLPDLVSGLRSIRVLVVSETEGHDLLRVQLEQGFVQILARLVVVVRILFSRPVVRVTETEDGELHLGEVGDLTRLEGLPQLTAVLREFTLSGDRGEEGNVFLKRDILDRHVVEGKGASSDTALSGATDELPRKLLGVTTIGREENEQRRTLERVGKGVKGLSCLPFLQSDQLGASAALERLTEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQM7</accession>
    <name>A0A2X0MQM7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C024g09893 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C024g09893</name>
        <name evidence="2" type="ORF">BQ5605_C024G09893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ26348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQM7"/>
    <dbReference type="STRING" id="796604.A0A2X0MQM7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ26348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="100" mass="11458" checksum="B98530F855DB0B59" modified="2018-09-12" version="1">MSTSWRDPVCSLDLPSSTRTQPDLYPHLLKHIDYHFTRFHRGPYLHSTETSGIGSDAFVRIRPRLLDCPDQELGPSRHDATIHRIMRTSPAHRSTSSTHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQY4</accession>
    <name>A0A2X0MQY4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C041g11932 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C041g11932</name>
        <name evidence="2" type="ORF">BQ5605_C041G11932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000119">
        <property type="protein sequence ID" value="SGZ33123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQY4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ33123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="322" mass="35024" checksum="10968FAD5D10786C" modified="2018-09-12" version="1">MDVLARFHFDTTTRGATVPMTPGLSLTAVPGQGTERIWSWYLQAIGSLLYISLGTCPDIAFAVSYLSRFANNPGRRHWVAVKHVLCYLRATYRDELLYACGPTKITGVVGYSDANWGACVDTSISTMGFVFYLAGSAVSWSSKRQTRVADSTTDAEYLALSHAGKEAIYLTQLLSELHVRPVDAAHIFTDNEAAAAVAHDPVHTSGTRHIRLREHFVRDMVHQGDISLSHVGTANMVADIFTKALGPKIFGVHCYALGLRTRHPRLKSTSRLRGGGGARGASQAHRPRARRAERAWDLGALAQDLGARSEPGKLGGARLSHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MRT1</accession>
    <name>A0A2X0MRT1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C066g12824 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C066g12824</name>
        <name evidence="2" type="ORF">BQ5605_C066G12824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000134">
        <property type="protein sequence ID" value="SGZ35287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MRT1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ35287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="221" mass="24292" checksum="71CCA65E8B611E28" modified="2018-09-12" version="1">MIVTRSQSIAVLSTPATPAPKADPMPPTPTKMPTKKPKTKKHPQRTWTTLWSNMMSTTKIPNVSFVAANVQSINEDRKRASLFSNLCSHNADVFLLSETGQPSPERVAQWTQECQDLKLSALFTPLNNTAILWKSDSVVITIDPESPPNTLHASFSFPDRVTDATFRVGDSKIRVVSIYAPSSDKPDKKCFLSHLSTALRQVVRDDPSPPALLVGGGLELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MRY0</accession>
    <name>A0A2X0MRY0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C018g08774 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C018g08774</name>
        <name evidence="2" type="ORF">BQ5605_C018G08774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY26756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MRY0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="115"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY26756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="505" mass="55625" checksum="C4BF509A65A1FFD9" modified="2018-09-12" version="1">MDAALYSPPPVAYLTSGVAALLNTSLADPLELIAPARDPPHWRAAMATPQADEWRLTAQAEFDSLSRDFSAFTPIDESLVPVDSKVLGSRFVFRTKRDQHGRIKSYKGRLVARAAHGYHVYQADIDKAYLHGKLDTPLYIRVPEGIYMPGKVLQLHRSLYGLRQAGRIWNDEIDSALSALGYRHYIALYVDDLLMISPSLPEIERTLQGLEQRYGVKHLGEAEYVLGIQIQRSADGAISLSQKQYLKDVLARFGMSNAHPVATPMQADLRLEVKLQPTPFPDRTRYLQAIGCLMYASTGTRPDLAYTVGYLARFSQSPSAAAWGAVKHAFCYLAGTLSHGLRYACGDPAPLVGYSDCNWGACVLSSKSTMGYTFVFAGAAVSWSSRLQSRVADSTCNTEYLALSHAGKEAIFLRQLFGELGLPSSRPVLIYGDNQGANALTKNPVFHAHTRHIRLCEHFVRDMVSLGDISVQYIATGEMTADIFTKALSRNLFARHCGQLGVCSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MS80</accession>
    <name>A0A2X0MS80_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C050g12509 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C050g12509</name>
        <name evidence="2" type="ORF">BQ5605_C050G12509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000097">
        <property type="protein sequence ID" value="SGZ29810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MS80"/>
    <dbReference type="STRING" id="796604.A0A2X0MS80"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="686"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="687"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ29810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1025" mass="111551" checksum="D1ED9A145418463D" modified="2018-09-12" version="1">MELGAEMKARPSGLVLYASGTVKDACVSFDALHARLVALPHQKLPSTFWQALHRFHIILKALEPPFTTTIPSASAPRPSISVTAGPTPTRLVVRIPAATVPQIKRSRLSSDDDDDDSDLETNSSSSSSSAQLWTPRSRSTTASKSSEGNYARKRPRMVTAETTNMTSPLARYRGSTVETSKSPRALGQPRTSSGRVDWRAVAQLETIANISPATPGEQLARALHLFGDPAFLNKFGSFVCDVINPSRLEQLSAARDDDLTSVGGQAGESGGRPSLDAWTDREQAAKSELIRLCRRVHSLQDREMSIRYQRCLEGMRLVQTQDDFQKGLGLPTEGRTVSGELDDREWVRGHLQTRCRLRCRVGFRQVSSVSPHMLPYPVSDTSFATHPFPLPPSRTGCPYVSLVLFFVTDGFTIDNTISLGSAMEGLVAGSTPPKDGRAGNAATKKWSTDYAYLQNGLRYLQATVLTLRTLAPPIPVTWQGEDVLLSDDSYGKWKSQQTIYSVGGSCLSGHWAAKKHISNPDVLFSSLRTEKMAMSLADAARCLGKPRGLGVVPLVNETTDDALLPRIEATDLGMQLLSTSSGANEARNNGTAITTLTNSRSRQDFLRFSQGIVDGAISSAPFDHFASIDAAMDCVRRLDVADPDTLCESLNIEALQCTDTSLGPSSKRGALRQVCMALGAPAEDWETDSKAAELESHGPQHGASVPSASRLDIDIDGETLRRGQDRLRLLLAEEEAMGNIEDISTLRDFEAMHGRLGRSGGKKFRIKREFIEQYGAIIRDPLNPKEPLIVLHPAKVFPEAVKRSVESSIRDDLFFPPGPMRMERELRLERGEQAQASCMIGLQLRYAKAPYVIKSAKDLGPVGGAVLAALHPVISYLDDSLKATSPEAHATLETTQALARASLDNVPRFQTNVAINWESVIGAHIDPDVSRAMCSLFVGGSFEGKPFARGELCFHELGLIIECGDGLAVHFQSSRLIHSSFPFSGSRYSVVFFTSQEFASKVAAGRSADAWNGLRVDFDGDSFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MTR5</accession>
    <name>A0A2X0MTR5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C002g01517 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C002g01517</name>
        <name evidence="3" type="ORF">BQ5605_C002G01517</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY33626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MTR5"/>
    <dbReference type="STRING" id="796604.A0A2X0MTR5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF7">
        <property type="entry name" value="REDUCTASE (YAKC), PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="223"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY33626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="370" mass="41025" checksum="295A5BF0F3B29770" modified="2018-09-12" version="1">MPNDTFTIDGQTWPRPGFGAMGLSAFYGKTNFEEAQHTLRAAIKSCGTPRMSGTDLGSSADSSYGFGKNEELISSILASDPELRKKVFLVSKWGLRWGSSIPGGFKVDGSPEYFEQAIEASIKRLGFTPDAYLLHRVDSQTDIEESIRAMDKARKAGKFKYLGVSECSAATLRKISKITKIDFIEVECELGRTSADDRPFLASGADQILHLAVHLADSLWTLDMERNGVLETCKELGVLVNAYSPLGRGFLTGRYKTAADFKNDEDWRASLPRLQEEVFEQNYKIVEEIEKIAQRKGCTKGQLALAWLLAQGDNIIPIPGTKSEKYLLENFASRKIELTDEEVKELRTIAEKHAPVGTRYQESGMGTLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MUP3</accession>
    <name>A0A2X0MUP3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C011g06675 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">BQ5605_C074g12910 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C074g12910</name>
        <name evidence="1" type="synonym">BQ5605_C011g06675</name>
        <name evidence="1" type="ORF">BQ5605_C011G06675</name>
        <name evidence="2" type="ORF">BQ5605_C074G12910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000129">
        <property type="protein sequence ID" value="SGZ34964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MUP3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY12998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ34964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="174" mass="19227" checksum="54B8F8897167E9BF" modified="2018-09-12" version="1">MGRRLGNKWICAPGTSARPEIWICAPRRTLLRARDSSSLVFCATHASSRATLARTHAAAFFRTHTPPQRQPCPVIPRFHNDSVSLKSQKLSIAIMRKLDGIISTWERELAAKGAVLGTATFTLHQHRSLRHLNGTSSLDGAYTIWTCSMYNQVLKLYDKAGQGAIQDTLPSKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MVE3</accession>
    <name>A0A2X0MVE3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C004g02602 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C004g02602</name>
        <name evidence="3" type="ORF">BQ5605_C004G02602</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY65866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MVE3"/>
    <dbReference type="STRING" id="796604.A0A2X0MVE3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF10">
        <property type="entry name" value="TRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G02040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY65866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="498" mass="57045" checksum="C573E3A535B5B112" modified="2018-09-12" version="1">MLPFARTAAPPRPGTHEKSRSIDQRPSFRPCHHVPSPSRARRLVSSFARYISLMLVALVVFCMTIMVLDYVSLFDARPYTVAGRLNTDWSRHIYAPSITRSQVTFSNVWPEEPIQAWDTIERVHTPEGRPRASLDANGRMVYVYPDGSRITPLTPLGTAADGAFKNLIYDRLEYMTTLENFLRHNFPQEDSDEQATRSLINDMRVFFPLVKSLLNQWGSPKPRIPPKVYQNAPMKSEMLRPDYVDTRAEWRDLIGWTMKAFVYGRSKMGEWVKERFDLNAGTDHGTEYEADDDYEEPGMDDLPYERMLKRVVPDPTRNVVTTYEALTADQAKSDLWQILIILTSGGVYTPFNYRPTRKPTEWGLWPTTGKACIARSSTSCKDPGLIAGVSFVAQDRSWRKRASRPIMLTPNYLGARRGHPVLVDTVRRVQLAILNNEAGPKSPISVASHFTDAMINWMLVRHRLAWSELLEMSEKGWRYRGEREWGDVKLVPVEGFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MXE3</accession>
    <name>A0A2X0MXE3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C001g00314 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C001g00314</name>
        <name evidence="3" type="ORF">BQ5605_C001G00314</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY45650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MXE3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1256"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="650"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1831"/>
            <end position="1868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1854"/>
            <end position="1865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY45650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2079" mass="230984" checksum="1B9592879C02FCE9" modified="2018-09-12" version="1">MQTGDPGSAPGARAPPPPASAPTSLPIAGTKETQATQVAGRTATYAAATNSSVVSNETPAQQQDRLARLQALPGILAAIQAVPGNRADRFVQAIFATPDFPSTVATALKFSALNATRNIINPFANALEVSLSHKSTGRASATDKGELVACVRTLLSPNTPICFDTGVPLSGDLEAFMPRITGLQHSSTFRTGVLHHRITVGFVSAEARDAALASAPMLVWNSANARFAKAHPFHRNMLEMRINVGVVRPPSKEQIVAAFQSIVQQLSTKGHSCQLVQVLRVIHVDTAKAYAHTVGDFSAFIHFDDASLFQHPTTTLKEILPSRMDLPTRGLDVTAVRHDYEKEAPCARCHFAGHVERCPLMQAANRKEAEDLARHAVMRGAGMVGGGEQTGVGRAATTTTNNIRPTANNNNTSEVVAPSRALGTDQLESRNRFAGLEVEGGQEDDIEEEVAGKEGEEKEQVEEGDEDTGAKADDEDSDSDGNTGAGIDKAGGDGKDDDKDNDEHDDKDEQDDSSEGSERRGDDVMKDGAEEEDEEMETEVEEEVEQEQGVQDDSIMIIDDGQTTITTVSRESTPRSPSWPPLSPETLAKSLREGAEWDRANAEAAARVQAENEAIINAQLDAQEPLVRHQFAEWGQEDGQLRFINIRGTGSRSNKKMKRSQTVADLSDPSDDPVDVKRVLNRVKGRAGKEVAGQGKRVTRSMSAAAAMQVEGAKAKAEKGQHYRQEHVYIVYPIMIKHLITSWNVRRCMGIPEKRRDIYTYLSTFKASAILLQEHFIKPELWQCIKDEYEGKAFISKHCLTLIPADSPLIDAEILRTHSALDGRILVTSFRLRGDIRILEINNLYAPVDTKQRLTFFDKLHFHRTQSTHLRLLGGDLNDCPLPAIDRRNQGRHGHHWPILIGKLDSPYTDCIRFKHPLTPSFTRPNIVRKRPKSFSRLDYFLLQRTHQKRLVQASTIYDHPKDLSDHRPVSIVLVLSDERGDAAEPNNSLPTTSNQLHRINAATFKTAAFQGMLEGWLEGASGEEPVGELEVVLGNCEKEGRELARREHRERVERMAVLVGRVQDLEALPVMGDEETAEWTRTTEELRRAVNERARQLRIRAHVPEIATEERLSRPVHAKLAARSSDSKITALRLPNGELTHDIDVALDHTQAHFQRLYNLEPRDRDHVERLRDDFLAPIRSARTCDDPSSDPLFLRRLSEAHIELLQQPITEDEVVAAIATTHPGRSPGPSGVPYELYHTAPRAWAKALSRAFNAMTERGSLSPRQGQGLVRLLFKHHKIGADRAELSSYRPITLRECDYKLFTKVYVARLNHVLPDLLPPQQHGFVKGRRSADASFHLRLLIEELGARGTEFPDAALLSLDQSSAYDLVEHEWIFAIFDALGAPATFQRVLRMLYSGDSTTARYIINGFLTPPVRLTCGLGQGDPASSSVWDVVFQPFLDALHRRGIALNLSLPTIHPYPQSRAITSLAFADDVVVAVAGSESLTLLDDLALDWRLATNGRLNTDKTVVLPIGCRWEAGDRPLVVKAEGESLEWIGLSFDPTGNTELANVNLVARLEAVLDSARDRGLTHHTRAFYVNRYAIPKILHILSADIPPLEVVKELDRILVDFVRGGKRRSCYGKDVVFTPRFKGGLGVMRMQDVVDSVAARVWDVLLGGSDAIWQGLARAAIVRAHPAPDFDLATDAWPCDYTPIRTDLHPRWQAVLKVPSTHNAQVKPRTLTLANLLALPIKLHTLHYLPGAPAVSRPPYDADYAAFAIYAKVADLFRRELYPGGGFHLWTPPTDVVVSNSEYDQRGRPQREHIVAWYRHAINRLRFTPIAQPVAAVRINGPPRVRPRSEGRPTTPLESILPHPIDPPQRLPRPALPDQSTQYNLLSMDRPYTIRRVRRVLNAKAFTDTIGFRDSLQPDDIKGFWKGVNSKALTAREREVWFKLVRNFTPTRSLQFHQKHDDSPACLVCGAPKDDREHYFFDCVDSGNVWIAARGVLCDALGLDTIDNTHYTAVQRMFGLPKLKASLRDQEGAGRTIEIFTGLVLEMISSGRWGMQKWGTRMEGVVRRRIILEERLKLRAGGAWGRRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MY08</accession>
    <name>A0A2X0MY08_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C001g00534 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C001g00534</name>
        <name evidence="7" type="ORF">BQ5605_C001G00534</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY47466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MY08"/>
    <dbReference type="STRING" id="796604.A0A2X0MY08"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096:SF1">
        <property type="entry name" value="AROMATIC RING-OPENING DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G00640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006157">
        <property type="entry name" value="Doxgns_DODA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53213">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Extradiol ring-cleavage dioxygenase class III enzyme subunit B" evidence="6">
        <location>
            <begin position="8"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY47466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="310" mass="34362" checksum="319AC9ABFA399A6F" modified="2018-09-12" version="1">MKSTPTPVIFCSHGSTMMLGEDSSAGRYWQKVGEEAMARKIEGVVFMGAHWEVNGNGFEIASNASEPVKQPVAWVSPDKYIDYNINVSPKLAERVHDSLTAAGIESKLNPNVEWSESVKSPRGPYSSRNCQLTLWLGLASLVHDVFLVLTWMFPKKSPPVTLISTNAYYDPYSHVAVGAALRHLRHENILLIGTGGTVHNLYRNAWSNIILHQDNFAQTKPPEPWAIAFRNEACDALTLNSGPALRKAAMRLMRNPLYRDAHGTDDHFAPVLFCAGAAGDAEDEGTKNTATAEVWELEQMCNTQFQFGEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MZ65</accession>
    <name>A0A2X0MZ65_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">BQ5605_C008g05125 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C008g05125</name>
        <name evidence="13" type="ORF">BQ5605_C008G05125</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MZ65"/>
    <dbReference type="STRING" id="796604.A0A2X0MZ65"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000004">
        <property type="entry name" value="AdoMet-dependent rRNA methyltransferase SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03163">
        <property type="entry name" value="RNA_methyltr_E_SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012920">
        <property type="entry name" value="rRNA_MeTfrase_SPB1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024576">
        <property type="entry name" value="rRNA_MeTfrase_Spb1_DUF3381"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028589">
        <property type="entry name" value="SPB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF13">
        <property type="entry name" value="PRE-RRNA 2'-O-RIBOSE RNA METHYLTRANSFERASE FTSJ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11861">
        <property type="entry name" value="DUF3381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07780">
        <property type="entry name" value="Spb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 8" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="10">
        <location>
            <begin position="26"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3381" evidence="12">
        <location>
            <begin position="261"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA methyltransferase SPB1-like C-terminal" evidence="11">
        <location>
            <begin position="716"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="387"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="901"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="469"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="500"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
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            <begin position="514"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
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            <begin position="530"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="567"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="586"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="626"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="659"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="689"/>
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        <location>
            <begin position="712"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="902"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="914"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="927"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
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        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="78"/>
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        <ligand>
            <name>S-adenosyl-L-methionine</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="94"/>
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        <ligand>
            <name>S-adenosyl-L-methionine</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF11861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGY79409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="945" mass="106205" checksum="62A12A89F2AB22BB" modified="2018-09-12" version="1">MGKGPQKKTGKGRLDKWYQLAKEQGYRARSAFKLIQLNKKYDFLSSARCVIDLCAAPGGWLQVAAKNMPPNSIIIGVDLVPIKPIPRCITLVDDITTEKCRRDIRAEVKDWKADVVLHDGAPNVGSAWVQDAFTQVELVLASLKLATEFLSAGGTFVTKVFRSKDYNSLIWVFNQLFNKVEATKPPSSRNVSAEIFVVCSGYLAPSKIDPKLLNAKHVFSDIDITTSTGVNPLSAVAALGQDGKISSKDTLTPTSLNVFQPDKKRRNRDGYADGDLTLHKECGVSEFIRSVDPIGVLGLVNEMKWRTDEDKKLFKHPLTTLEIKALVQDLKVLGKKDFKTLLKYRLAVREDYGLENKGGDGQGGTEGPDATEEVEVEPLDEDEQIAQELSRLSAEEQLRRKREKRRANEKKAREIQRMQLNMVTPMDMGLERQDGVDDADVFDLGEVEGNEKAGRSGVQGRTMAEDVIDEDEEGDEEDQGINAARAKLLRMAEQSAVPMDENDEDNDELDEEEIKMRRLERSLDTAYDMYHQHKMERDAKHKAKEERRKRDAKEGGEWHGIQAKGSDDEDDEDDEEDFDPAPQPSSDEEESDDEDMKVEGTLVPTTSKNGKPKSKALLTKLQPVVSEEKKTAEKSRAAQMWFDQPVFKGMPGLDKLLNGDDDEAADLEDEASVEASDDEDGETWNGLDSADEEEDDEELESEEDEYSDDDFTGARETHFEDSDMEEEADLKAQEEAEELKRQRIEEIGLTTAEAMTLAQQLVNREKTKTQLIDEGFNRYTSNVGGDGLPSWFLDDEQRHFRNNIPITKEAVLALREKMRELNARPIKKIAEAKARKKMRTIRRAEKMRAKAQGINDDEENGLTEKEKAASIAKVLSKAKSSAKPTKKREIKVVVAKGANRGIKGRPKGVKGRYKMVDPRDRKEARALKRIAKRDKKGGGRRKKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MZ67</accession>
    <name>A0A2X0MZ67_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C001g00954 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C001g00954</name>
        <name evidence="8" type="ORF">BQ5605_C001G00954</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY51047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A2X0MZ67"/>
    <dbReference type="STRING" id="796604.A0A2X0MZ67"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF26">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="511"/>
            <end position="587"/>
        </location>
    </feature>
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        <location>
            <begin position="41"/>
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        </location>
    </feature>
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            <begin position="244"/>
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    </feature>
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            <begin position="849"/>
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        </location>
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            <begin position="50"/>
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            <begin position="854"/>
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        </location>
    </feature>
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            <begin position="908"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY51047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1082" mass="115565" checksum="A4534E96E5CFAA27" modified="2018-09-12" version="1">MYSLANAIASGSGNGSAHGMPPLRASSASLGGGSIADYGIHSTLPPPNLPRMYPNPNSALSSSSNSGQNGMNNSSTNYGLPSPSALLMRANAANVANAANVANAANAASGSSPSSSSIPMLPLPPPANSLPGSLAHYDSMSRHPSGAPPLTTAQDRSPYGSSSSSTGKRRISASGSTMDVAETPDAAGSQDEQDDEDSASARKKRSKTPRACDALPDTEPPICVHCHSHHTACTWFLPIAETRNKRSKPKQADDPSSAVAASQLAALSQAHHRASSAGSQSMASPHTSSSIGQYHYEAHPSSANRPSFSSTKPLAGHLPTQMQTQGNQDSDPFRRNREMRIVGSTSISHLMHSTSTFPAERLNSVDSKYSQSLTVDETGDGFIRINGGGDYTGEAGGPDAHPQAIQGLDSPVAEQLLNHYFTTHSRHFPVVTRADFAANKKTSILLFNTLCGISGLSHHVAPGILRTIKGTIRATLREQDFLDDSSMSNIQALLVYTFSLELEKKTPASKTWNLLGVAIRMAQDLGLHRKFGTEKKLQSEADHCELRRRVWGGCLIADRWIAAIYGCPMMIDLADCDCLLPSVFDIRPGTEFDAERKPYLFNGALISLSILLGRIIKAIYSPTGIMTLSAADATSLFDDLEHWVSGLPSELRFNGPNKSTAEQGFLRLLYLPAKFLVTRPFMSISFQLPKRFAHLSVGVVEWGQLETESREAIEWVDKNEAVLEGWFVGIYAFFIASLIQYHSHIRRRDAEPLVTLKLARDIMKRVVVPDGETHLRYKISEILHLLYQTALSVQKWAPEAAEGMSPAFGSNTTAITTLNPTPGVRQREQDWHLKYVDKKGTNGVSYFRSERRTPSATSSPASAVGPSGAQAGSSVAGGSVISPLEPAESNGLLRHSPPLGNESSVRSMHQEGEENARPMDETPAQSVTGSTAVESPGQTDRMREDGAPTDGDDRPADEPTSTPMPTPGDFATMNFNPMLNFSAAATNANDPSNNADGAGSTSANASINPGAQGNPSATSNMFLGGIAGHHFDPFGFNTHPEMMNGGFAGAGGNMMLPPENIFDVDSWSSFFQNVPGMPAPKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N2C4</accession>
    <name>A0A2X0N2C4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetylglucosamine diphosphorylase</fullName>
            <ecNumber evidence="3">2.7.7.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C007g04891</name>
        <name evidence="8" type="ORF">BQ5605_C007G04891</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate + UTP + H(+) = UDP-N-acetyl-alpha-D-glucosamine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="3"/>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY64275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N2C4"/>
    <dbReference type="STRING" id="796604.A0A2X0N2C4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04193">
        <property type="entry name" value="UDPGlcNAc_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000075">
        <property type="entry name" value="Probable UDP-N-acetylglucosamine pyrophosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039741">
        <property type="entry name" value="UDP-sugar_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952:SF2">
        <property type="entry name" value="LD24639P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952">
        <property type="entry name" value="UDP- GLUCOSE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="59"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY64275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="511" mass="55497" checksum="AEE2B5D4D4551C4B" modified="2018-09-12" version="1">MSSPSAATLDSIRARYAAANQSHVLHFYDTLSPTQQDSLLSQLSTIDPERVNRIYAKAREVDASSSSSSSPSESESESNTFSPPPRDRVGVITPDSSNSPQVQNWTSQGLSSIRLGQVAILLLAGGQGTRLGSSAPKGCYDIGLPSHKSLFQLQAERIKRLQIVAQEAGGGEGVGEGKNLVWYIMTSGPTRGPTEQFFRENRYFGLEEGQVVFFEQGVLPCLSNDGKILLDTPSSVAVAPDGNGGLYSALDSPLSSTSSTTVLSDLQARGIKYLHAYCVDNCLVRVSDPTFLGYCISQNASCGAKVVTKTQPTESVGVVALKNNRYTVIEYSELPTSLSELRDDKGDLAYRAANIANHFYSLDFLTSIHTFSDQLTYHIATKKIPHISIPSGNLIKPTTPNGIKLELFIFDIFPFVEPTSFALLQVSRTTDFSPLKNAPGTGNDDPFTSRRDLLNEHRRWLIEAGAEVDEGVQVELSALVSYAGEGLEWVKGCKVKRRGRVEKRGDLEGLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N2D1</accession>
    <name>A0A2X0N2D1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C035g11398 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C035g11398</name>
        <name evidence="2" type="ORF">BQ5605_C035G11398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000064">
        <property type="protein sequence ID" value="SGY97356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N2D1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY97356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="124" mass="13172" checksum="AF4308C62E380169" modified="2018-09-12" version="1">MMVVVLQTSRAWGDGTAEITNENGSDSLPGSAQGSVRLQSERQKSGKDGGRKYNCGDISTSFFFFLTGAHKLQSFGLAGTATKRAKGGYKATTASSWVKVKPLRAKSAAQIKTRRAPNADSNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-07-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N4S7</accession>
    <name>A0A2X0N4S7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C028g10524 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C028g10524</name>
        <name evidence="1" type="ORF">BQ5605_C028G10524</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000080">
        <property type="protein sequence ID" value="SGZ12765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N4S7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF54">
        <property type="entry name" value="PHOSPHATASE SPAC5H10.03-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ12765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="219" mass="24684" checksum="233890E36AAF1C06" modified="2018-09-12" version="1">MPPRVFLLRHGEAMHNVVPEDHSIPDPVLTKTGELQALSVPSTYSTFFESLSLSSAVIVTSPFRRTMQTTMSAFASVLAPVSSSPIPLIILPQVQECGDQPCDTGGELSRVQAMFPHEWLDWSECTEGWNSNQGFYQATEEKQMERAKWVRRWIRSRTEDNVVIVSHHGFLRRITKTPAYDDCGVRAAWANVELREYGFKEGTGETEEADVERIPNSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N4T2</accession>
    <name>A0A2X0N4T2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C005g03476 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C005g03476</name>
        <name evidence="2" type="ORF">BQ5605_C005G03476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY76227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N4T2"/>
    <dbReference type="STRING" id="796604.A0A2X0N4T2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007145">
        <property type="entry name" value="MAP65_Ase1_PRC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321:SF41">
        <property type="entry name" value="FASCETTO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321">
        <property type="entry name" value="PROTEIN REGULATOR OF CYTOKINESIS 1 PRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03999">
        <property type="entry name" value="MAP65_ASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="522"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY76227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="638" mass="71526" checksum="AEEEB4B6311BE8A7" modified="2018-09-12" version="1">MSSLEVLVAQHRQKLTELYTLISPQPTELVSAQLDALQALLGATIDQQRLCAENERDQIQASLNKSWEKVGLWRTALGEDASIGKRRGTGPLKTLAQEVEEVLQSMRGRMEERGKQILGLNSRIATFVPSLGKEWLQVSLDDVEQGWEALDLRLERMSALEREVMRCETEMARRRDAINANVNEIFALRSELGIHQGDGTTTDDFDEAILAHLGIGDGRERKQLEPTSENIARAEAKRKWLEDEKNQRNMTIQTTYDKLYPLWTMLGVSEYEMEQFVNTHMGSTQDVVMAYQDELARMLTLKRSNLSTFIQRERVALSNLWDALYLSMPQRIASFPPLQVCIDSTRVWNEVTGAEEEIINNNVSEELLVAHERERERVEAEVERCQPVLERLGKYFSVVEEMAQLEASASDPSRLLGKSTRGDPGRLLREEKARKRVVKEKPRLEAELRHFIPAWEQQNQRPFLVNGVRFLDDLEKKMGAEMAEKENKKREKMGTKPITTTRPLQSQMTGASSVGPLKRQMTGRSATGTSTTGGPTAKRQTPMATGGVPRAVAVVDHAPQHYQQAAAHPMVLGGPTKLVPQMTGMKLPSGWGAPAAVAAPEQYGYQSTAQYGMAPQTQYSMPPLRAQPTGGFRPGPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N7P2</accession>
    <name>A0A2X0N7P2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C023g09755 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C023g09755</name>
        <name evidence="2" type="ORF">BQ5605_C023G09755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ24953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N7P2"/>
    <dbReference type="STRING" id="796604.A0A2X0N7P2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021861">
        <property type="entry name" value="THO_THOC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13265:SF0">
        <property type="entry name" value="HPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13265">
        <property type="entry name" value="THO COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11957">
        <property type="entry name" value="efThoc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="642"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="708"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="730"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ24953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="748" mass="84620" checksum="7A517748A26DDF90" modified="2018-09-12" version="1">MAIMSIMSIYTSLRTSLESHLSSALSTLERIRHEPTRTVDPITDPIDEQTMGRLVDGVVDGLQGLIAEDEKAQDGERLRRRNEVVRQALERSLEERLHETAWSSVDSVVGSPAMQFDLLDLMQTFSERGHTDVVSPLNAISALLDMQTISQCESTWLYIESRSKRLTKDMVPGKGKGLIILRMLNELLRRLPRSKQEHVIFSGRILVFLSSVFPLSEKSGVNLRGNFNTGKKTLYDEDAGRKGEEEGKKEGRENGEKTDAEQEEDGQDHEKAADQEKETEPTAEVKEDKVDSFYPIFWSLQRIFTDPVALVASPPVRGPDALDTLRLQLSKTLDMFAVETKKEKDLTGAATDPTKVVANGKALTLAMVTDGLVDEEALGDYFFPRFLTSRNLLKLELADPTFRRQILVQFLILFQFLISLTPPERIRTLSQGVTNTLVYGPHEVGAKHEKWLRDLRERSVRELDAMQHGRRFRDAIEVMLKREQHWINWKLQSCKPFELSPLPIDQVSKTARSKLVTLSRKPKNYPYKLGNPVLSGLWERNLTTLKDYEPDLPRNDFNSLLVEWQRCEKMIKSKKAVMEDESTDRVKKEEVKGEVEQHELRLSSLHWRATRAASLQHLNLFNKIKAGDFDLLLKAIEDANRAPEEPISPEPTQEVGEKAKEGTAAEGQKEMEGVEVEMALRLGSTREAPPLEGEGWIRKPSRVVLIETDDEKSVHGSPKRSIADAAIAGVDERSATSEAKRAKTDEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N8G2</accession>
    <name>A0A2X0N8G2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C025g09988 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C025g09988</name>
        <name evidence="6" type="ORF">BQ5605_C025G09988</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000087">
        <property type="protein sequence ID" value="SGZ26893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N8G2"/>
    <dbReference type="STRING" id="796604.A0A2X0N8G2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF69">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 11-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="534"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="792"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="534"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="548"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="567"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="617"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="640"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="663"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="699"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="752"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="792"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="803"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="849"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="874"/>
            <end position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGZ26893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="886" mass="94438" checksum="63899ECA6D743954" modified="2018-09-12" version="1">MTSTGATSSPVHADTVQGGSYITELASFVRRHESKLADFGRRPTPSSSSLPAWSSILSLGIIASSDASSPVASHQRKAPLVLEFDPHHLYFLLLKFDELGIANLGDLDVRIQGGVHRPMMIDYGLSGVPEEQASGWWAGAFGGGGSGSASTTTTRKKDSDTASFRSGISSFSIGSGWWGSTKAPVDESVDVKYLYASCTKLPALKLSPFITRSRSSSPKAAGPLPGHHASPLLSKAVQDFQDCPPDQTTVPLYAFKNLQSLILEDLDPRGFLGWDVMSAQLRSLQIHRSGIEDIGELICDVVVEDVERRKKGAGQVGQERIKRQKGPLSAEIAVEGDEEPEHPAHDTSFGRTDDGVPPSPSTASYPIPPRYAWSQLRHLSLSHNSLTFVPTPPLHHLASSLTSLDLSSNLLISVPTGLSALHSLRSLNLSDNMIDSLVGISKILGAVQVLNLSHNRLSNLAGLDRLLALERIDVRSNRLQEALEISRLQELPLLREVWVQSNPFTRSVHDGGEEGWKNKCMAYFEGGQVTFDDFSSSEGQNGSKSDSRGSSTLRRSASAAAGLGMADRARTEEARTAGEAKIVSRRVVTTPHQQGKHHRMALSPPPSPLPNASMGLTSTSAMESSASPTSSPSLGPTKVVKSSQPAPTSTDSAHRKPRRIVNLDGPSPRPGGDSSGLSDVDHHHHHHQSPKLNPGSRTVKSLSSVTGSSLTSPSKPSARRQRLSASTFEPPISYLSTSPPNRDHSPSRGGDLKSASSGSGSGPENSGEAFRKKIEQLRNEVGESWLSVLGERQEREAREAARAEGSANASASASASGGEANKVVKRPTVEDAQVNSSPVTTKEDDPVAEEAVTTATVTKVVKAHNEGDPTSTAKKGKKKKKSGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N993</accession>
    <name>A0A2X0N993_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C035g11390 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C035g11390</name>
        <name evidence="2" type="ORF">BQ5605_C035G11390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000064">
        <property type="protein sequence ID" value="SGY97244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N993"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23274">
        <property type="entry name" value="DNA HELICASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23274:SF51">
        <property type="entry name" value="OS03G0423850 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY97244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="257" mass="28862" checksum="E68124F70AF5E617" modified="2018-09-12" version="1">MCQSIWVDRLLRDLRETKELFGVVTTILAGFNLQGTIAIAFSRSLGTPGQRVAYASLIKADFRRDVRLRTSCVLARTLMRWTRLNWLGRPTLWNSYSKWVMELPAYTRTTRSPADEVVELGETGGVMPVKRPAPHLRLEEGIPVILGNLDTDTGLCNGYLSLACDLRRMRQLGFTMRRLQFPSRVVLAMTINKAQRKSLDCVGIDLPASRLRSWAVVCGIASSHECWPSPTCLSPLACYPVDDDDDQQAVDRLPQPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N9P2</accession>
    <name>A0A2X0N9P2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C034g11315 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C034g11315</name>
        <name evidence="2" type="ORF">BQ5605_C034G11315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000065">
        <property type="protein sequence ID" value="SGY99949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N9P2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="466"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY99949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="718" mass="75892" checksum="DA0AC8A550889FA3" modified="2018-09-12" version="1">MTRRLHSPQSPPTSSIAATATKVERAQTHYASRALPRIASQISDSTPTRPSRRAVQPQDSPNSYENCGYIDFGTVTNCRRSFNSDASLRKSTRRAAPARSFNPKSRALPISTVSATARPSSPPTAWASDALAPPSPILASSSPLSLGMHPVLDGSASLSRDRAPSPSSSTPSHFADALAAGELCLSPQRATEEQGRYSSVEAFEHDFEDESHPFFDNEVSQFLQQLQANEDGESQFRDDCFAAATEESTSTCAASTSGSVGRMALPQVARKQLALAQSTWSPLESSSTALPLPVRLHHTHFPASPQTRPLALQPSVGTLHAHSPSSAMPFDGGSDPNASFFETPFFDFDIDAILTAYEAVSSDDEDQDEQNDYNIDLNFTPRMSSVKSTVRPDSSKRSVARIRKPIFPSPAQRANPDPRGSQAVFPSTVTSFKPHNFSKLSLQTANLSPDSIVGASPPLPLPAPPAHHASANASASRLSPATAPSRQSTFSSIGSSSNVSSPISTRSSGFSSNGNGSFRWSSASGSTAHTIADGEGLDVFGRCFPSPVKRGSDASVYSTASSVAAVLPTTGPPRRVLLEGANSGGAIVDRRAMACTEDDAMMNWQQFAEEIGASEEDALDTTTPSVAKSSPLSPPPFAFARTAAVAADRPSPASSTSTLPLPGVVPAIDVGPRSLVKKMSSLSLKRFKRSVVGPSPANPPPMPQYASNLVMMHSLHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NCM0</accession>
    <name>A0A2X0NCM0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C020g09193 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C020g09193</name>
        <name evidence="3" type="ORF">BQ5605_C020G09193</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000082">
        <property type="protein sequence ID" value="SGZ18619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NCM0"/>
    <dbReference type="STRING" id="796604.A0A2X0NCM0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050659">
        <property type="entry name" value="Peptidase_M24B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46112">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46112:SF2">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="2">
        <location>
            <begin position="340"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ18619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="575" mass="63486" checksum="0010041CB9562982" modified="2018-09-12" version="1">MGSAPPEADDYDLPLYSVHEDHHKPFLLTDEEAQIGELDQEGPSTPSSSSSPSPSSSSSKRVPPRYSISLVIGPSHFTLRIHGGTLILFLLASLFVSRVVFQTLSCFSPKSASSVGQSGKSFTLHPSTAKIHQGIDWSGISPEKVCEKEEGKGIDLEEFAKRRDTLARLLGSGEKDNWAVWVSEPSPNTLYYVNLSTRDWYLSERPWLVVITPSISTSSPKAHLSILTPSFELSRTKRLPFALSSSDLSQISWVTWEEAENPYAVLSQHLEHLYASYLSSIKESKAKWTIHLEENMRQLVADGIGKAVKTVEGRGLEVRVGLVGESIREQRMRKTKKERELLRCVSKVTMHALRKVQTHLQIGMSEKQGEALIYNALTSAGLTDLSIIVLFGANAALPHASASADKWLEEGEFALFDVGGTLKGYISDFTRTMLPNPRSSPNPSIEPSWPSRRSQTIWNLVHDAQSTALQTLDKHINITAAKVDLSARLIITEAGYGDHFTHRLGHGIGLQGHEGPYLNAGNAKTWLKEGEVFSIEPGVYLENQLGVRLEDLVIKTDEGYELVWSAGLAKSPWLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0ND94</accession>
    <name>A0A2X0ND94_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C063g12773 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C063g12773</name>
        <name evidence="1" type="ORF">BQ5605_C063G12773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000139">
        <property type="protein sequence ID" value="SGZ35616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0ND94"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ35616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="97" mass="11027" checksum="6BE46CD335C7D6B8" modified="2018-09-12" version="1">MGSYNRRARKSLPDRIRTAKKHIPDACRNRVDDVLHPHDPKTPLEPRCEDDVLAITRPPLAAADKVDENAIKLLDDLERWDVGGEDVQNLGMAYRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NMP7</accession>
    <name>A0A2X0NMP7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C010g06071 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C010g06071</name>
        <name evidence="1" type="ORF">BQ5605_C010G06071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NMP7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY14124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="187" mass="19737" checksum="A57562C5597B3677" modified="2018-09-12" version="1">MAIVIASSHKCLSAPVSEFDGLARTLLLRLSLLMQHDVHRGLISRFRFSLFTPTTIHLSAVDVGANLVDSKSAAAASRTTRQGILAIATSRNLPGSEALSAQPRPSPSADQYINVTTYSAFRPLSTSLGSSLARGSLSDSCTHLFPHILSLHRVPTPADVALAVQRAFSAADGLSFVGPGRETLSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NP74</accession>
    <name>A0A2X0NP74_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C013g07403 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C013g07403</name>
        <name evidence="2" type="ORF">BQ5605_C013G07403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NP74"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY15559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="581" mass="60743" checksum="FCFC5FBCE267F193" modified="2018-09-12" version="1">MLERREAFASVLRQSLDDALTLSFGRAGRTQGYTLMQLQRGLAVNPNGDPMAMTEDGFHCAYLRLHADLFQGSTETQKAALNAALPQEIEILGAKYGLRHEFETHYCAVCDRAGHQWGACRKPVSTPATAAPVPGASTSTSTTGFRVAGKNGKHGGPAALNSRASGTNMIQLGPRAIPAGAATGNKDDANDDDGGGESVASTEPEGGDTGKETLTRATTGPTKETQTTTAAPVSTPTSPSPSASAPASPLSGGTSESSATSTTSIASTSPRRLRSCEESTLRSVQDLGARSEPGASRTDLCARSEPGASARDLGARNEPGLLGYQPTSYQPATRVFFLEPQPLEPHTSITHRTMDSSPNTPSPHRDSSPLASSISDQIATLQAQLAALQASQPPAAAASQPTAAAVVANPATVATASKVVFPKHARLDGPKSFTNWLRQLRLALPNQLRAYVLDGVAPATWTADQLAARDDTAREIIVGSIDSADVSATLDTIPSDDLSAPRIFAALKARFAPDDATRTLDGRQRPLQKTLTTRGGGDQAEGRSTGRRQATEGQPRRGRGCEARSKSSISDFIANEIENEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NRV2</accession>
    <name>A0A2X0NRV2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C014g07656 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C014g07656</name>
        <name evidence="3" type="ORF">BQ5605_C014G07656</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY19472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0NRV2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1264"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="652"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="560"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY19472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2082" mass="232082" checksum="743136CDDC5262F3" modified="2018-09-12" version="1">MSTGDPGSPPPAPPPPVSATSVQPPRDQIPISSKKTQVTGPATAAPNYAAAASQATQSPEQQQQQQQRAKALGSLLQAMGAVPGNRMDRWVQAIYFAELYPVATATSLKFSALNANRSVENIFDYALEVTLSHQSASRASHADKTDLVACVTRLLSPISPICFEPGVPLPDHLAAYRPQILGVQHSSILRNGAAHHRVTVGFVTGEARDAALTTPPALTWRSAKARFAKSHRFHHNMVELRINVGVQGVPSMDAIIKSFQLLVQDLSGKGHSCQLVQVLRIISVDNASAFAHVAGDYSAFLHFDDDSLFKRPNTTLKEILPSRIGLPTRGIPVTALRHDYEKEAACGRCHFVGHVGTCGLDQESKRKEAHNGNGNGNTNANKNTITNDTNIVEAEAPIPVPVVNRIASQNRFAGLEVEEGQEEAVTGQSGQGPEESGEEDAGDKADDEDSEDSEMESEATAKTEVIKLKSEDESVLEDCGGSDGEVIDEDEVMADGRGETEGKVATEMEEREVATEMEEEEVATEVDDVDEAGGATKAENAEATDLGETNRLDNDDDSDATATAATASRESTPHEPTPPLSPETLAKSLREGEEWDRIRANWVEQARLERDQSIERRLDAETPLVRHNFATWDEDGEIRSINIRGTAAKFKKPVMKRSQTAADLSDPSDEPTDAKRVIIKGKSRVVVKDGTEGRRVTRSMSAAAAMPVGVTKVDRGKAKGVAEEKRWSDHEPEDDRFDLNYPLMIKHTIITWNVRRGMGVPEKRRDIYNYLSLFKASAILIQEHFIRPHLWQLIKDEYEGKLFINQHCLTLIPADSPLIDAELLRTHSALDGRLLVTSFRLRGDIKILEINNVYAPVDPKQRAKFFDKLLFHKTQKSHLRLLGGDLNDCPRPEVDRRNQSRRGHHWPILIGKLDSAYTDCIRYKHPITPSFTRPNPNRKRPNSFSRLDYFLLQRTHQKRLDQASTIYDYPKELSDHRPVLIVLALSDDPDATLPQLSLPTTSNQLHRINTTTFKTVEFQRMMEGWLEGASGEEPVGELEVILKACRDRGGEMARRLHRERTERMEYLVGRVQDLEAIPEWGEAETAEWTRTSEELKRAVEERARLLRIRAHVPEIASEERLSRPVHAKLAARNSDSKITALRLSNGELTHDIDVALDHTQAHFQRLYHIEPRDPDRVDRLRDEFLAPIRAARTCDDPRSDPLFLRRLSESQIDLLQRPITEDEVVAAIGTTHPGRSPGPSGVPYELYQTAPKAWAKVLTKAYNAMIERGSLSPKQGQGLVRLIFKRHKKNADRAELSSYRPITLRECDYKIFTKVYVARLNQILPDLLPPQQHGFVKDRRSADAALHLRLLIEELGARRTEFPAAALLSLDQSSAYDLVEHDWIFAIFDALGAPATFLRVLRMLYSGDSTSARYIINGFLTAPVRLTCGLGQGDPASSSVWDIVFQPFLDALHRRNIALNLSIPALHPYPQSRAMTSLAFADDVVVAVAGLESLNLLDDVALDWRHATNGRLNTDKTVVLPIGRRWDPGQRPLVVKAAGESLEWIGLPFDPSGDTELAYANLIERLEATLEGVQHRWLTHHTRAFYVNRYAIPKILHFLAADIPPPEVVKKLDDMLVDFVRGGNGRTSYGRDIVFTAKLKGGLGVIRMQDVVDAVAARIWDVLLGGSGAIWQGLARAALQRAQSDLDLATDLWPHPSTPIPSDLHPRWRAALGVPKQQDAQANPRTLTTANLLALPTLLGSLHTPIRGRQTIDAVHIPDYLRLQGYPKVADLYRRELYAGGGFHLWTPPADVLGDNSEYDRRGLPQRLAIAAWYRFTVDRHKNTPLAVAVAAGRLNVPPRIGTSAPLEAILPKPVARFAMEQRLPDPVLPQQASQYKLLNMARPYTIRRIRRVLNAKAFTNTLGLKGPPQPDDLRSFWKAVNSKALTAREREVWFKLILRFTPTRKLQHQQQHDTSPACLVCEAPVDDTDHYFFGCVDSRNVWIAARGVLCDALGCDTIEDAQYTTLQRLFGLPKLKAKLSEQEGEGRTIEIFTGMVLEMISSGRYRMQKHGKRMESVERRRVVLEERMKLRVGGARGGRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NS00</accession>
    <name>A0A2X0NS00_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BQ5605_C011g06468 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C011g06468</name>
        <name evidence="11" type="ORF">BQ5605_C011G06468</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NS00"/>
    <dbReference type="STRING" id="796604.A0A2X0NS00"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="8">
        <location>
            <begin position="587"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase RNase H-like" evidence="9">
        <location>
            <begin position="804"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase zinc-binding" evidence="10">
        <location>
            <begin position="973"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="330"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY12327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1213" mass="135423" checksum="C68CE9F27B58F081" modified="2018-09-12" version="1">MPTPTAPSHSPTYKPNDPPQLHSTSMEALREYFMRLDFYNRRIARTPITSDYNKIEGAGMGLQVFALKTWFAQGLSKHLAKPYTQFKSELIRRAVPADFVWTQLAKLHRLRQAPGHDIDAFQEFSDQMRSLQMEIGFQVVSDQEVAKLVLLGTDPELCRILRTHMVSSLAGWSDLPLEKLALDTPVVPTSPEAAEVFSDAHTDQPLEFDYQVFERIGREEWSRPTYSRPAAASAAPHVTTAATGHSPITGGPRPVARLTVDERTYLDQNHGCYRCRTLNADHISRNCPRYLSPMGASATPSTPTSTALRLAPGPVWWRPFGPSKKLAIQPCSSASPATRRTNNDPSYAPHPFPPLPVSLAGAHGTLLASALVDSGLPQTFLSEELVQRLGLERRALEQHSKYTLAMQNQVPHCLHLHALCSSPLELAMALAQTTYAEVAERHEMLSSLTGSESKLKGSNVAPLGKDLAIILGGNFIYRHKMELGLFPQPHLTCKANPIHAIDLLALSSQPAPPCALDHRLRAEFADRFPADIPPKYREAWYLLLQEHLAAGRLRPSRSAYSSPSFIIPKKGCDVDPTIAPRWVNDYRELNKHTIKDRSLCPCRTHSLDTSIRRRVHTLGLYEWTVMPMGLCNAPATHQRRVNEALQGLLGTICFVYLDDITIFADTLEEHEARVCQVLDALRRAELYCSPTKTNLATAECSFLGHIINRAGVHADPKKIQRIEYWSLPKTVKELRGFLGLVQYLRKFIPGLAEHTAALTPLTRQGLSSIATLWTPNEVRHFKAIKAIVTSLDCLRPPDHSANAAPFWVMTDASNQGIGGVLLQGQEWKVARPIAYWSRQYIPAERNYPTHEQELLAIVEALKEWRIDLLGGHFHILTDHSTLEHFQTQRTVLSRRQARWLDTLAEFDYDLRYLPGEDNILSDAVKQQILDAYETDPFCQQAMSNIGSVTSDFKIVDALLYLRGRLIIPSLAPLRESILHDAHDAQGHLGDMKTYRTVQQAYFWPNMSRDVKHYVQQCDSCQRTKARTTRIAGKLHSLPVPTRPMADIAIDFVGPLPANKGFDRVLTITDRLLDTSVCSCPAEADTAAEVAARFHEGWHRLLASLKAFVSPETDGRSEKTNKTAFQILRALVNKEQSNWAECLGCLSCLATRLPAPCPVDSDDDLPSVDELLAASIPACKDARTRLAIPRFGRQHSPTRSARMNPLGPLGILFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NU26</accession>
    <name>A0A2X0NU26_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BQ5605_C013g07197 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C013g07197</name>
        <name evidence="12" type="ORF">BQ5605_C013G07197</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY14990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NU26"/>
    <dbReference type="STRING" id="796604.A0A2X0NU26"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03448">
        <property type="entry name" value="HDE_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05353">
        <property type="entry name" value="hydroxyacyl-CoA-like_DH_SDR_c-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054357">
        <property type="entry name" value="MFE-2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051687">
        <property type="entry name" value="Peroxisomal_Beta-Oxidation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024:SF2">
        <property type="entry name" value="SCP2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22622">
        <property type="entry name" value="MFE-2_hydrat-2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="11">
        <location>
            <begin position="311"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="592"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="759"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="597"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="614"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY14990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="892" mass="97064" checksum="82A5029C53949062" modified="2018-09-12" version="1">MSELQYKDKVVIVTGAGGGLGKAYSVFFASRGANILVNDLSRENADKAVKEINDAGKGQAIANYNSATEGNAIVKQAVDKWGRVDILINNAGILRDKSFVSMTDKEWDIIHDVHVRGAYACTKAAWPLMRKQKYGRIIMASHLDQSAGIYGNFGQANYSSAKLALVAFAKTLAREGAKYNIHANAIAPVAASQMTETVMPPEMLANLSPEMIVPLVAYLCHDQTEDNGKLFEAGAGWYGRVRWERSKGVVFKTDDTFTPAAVKAKWEQINDFSSGSTFPENITDANYLEYLEEAKSIKKNETDGEVRFDGKTILITGAGAGLGRAYALMYAKLGGSVVVNDMNKEAADSVVKECEKLGGKALAVVCSAEEGEKLVNAAVEKFGSLHVVVCNAGILRDKSFAALTDEEWDLVYKVHVRGTYSVCKAAWPIFRKQKYGRIVNTSSSVGVHGNFGQANYSTAKSAILGLTKTLAIEGKKYGIIANTLVPNAGTNMTRTIWPEEMVQAFSPAFIAPVVGYLTSEANESTLGLYEVSGGWCAAYRWQRSYGYAFPIKTKVTVEKLKAKWDVVNKFDNKATNPNSTAESLESIIDNFSNESESSSDESGDDDYSDPEDPEIVKKAKESAKETGEYTFTERDVALYNLGIGATEKEVEFTFEGDSDFRPIPTFGVIPQFATSSGLPMDWLPNFSPMMLLHGEQYLQIKGKIPTSGTLTSEARLSEVLDKGKAAAVTSITTTKDSEGNVIFENQSTVFIRGAGGFGGKKTGKDRGAATAANKPPSRKPDHVEEEKTLPIQAALYRLSGDYNPLHIDPDFAKVGGFEQPILHGLCFFGISGKHIYKKFGEFKDIKVRFVGSVYPGETVVTEMWKENDKVIFQTKCKERGTVVLGAAAVTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NUG5</accession>
    <name>A0A2X0NUG5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C013g07337 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C013g07337</name>
        <name evidence="3" type="ORF">BQ5605_C013G07337</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1061"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="449"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY15343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1854" mass="203337" checksum="CF3AA2D6FCB29B96" modified="2018-09-12" version="1">MPDPPGAQAPPPDNPLGGNRASDDESLNTLTREPVTGGTANPPAWSTEATQARLDCEKVMQNTFRVLGIVPSGKSTRRLMVLMHDASTPPSQAPLLARAAQRAVRNDAAPASNVIRVIMDGPGSPRGPVQIALRKHFGLAETPFMFARPEGVVLDPEVEKLFSKCVKLNPIVTKATKRFPIARHMYELVFESDQACLEAAAAGPFSHHGKEMVTELPSASPLNHVVQVRFTLPSSSSATPASVLRQSLDDALTLSFGRAGRTQGYTLMQLQRGLAVDPNGDPMAMTEDGFHCAYLRLHADLFQGSTETQKAALNAALPQEIEILGAKYGLRHEFETHYCAVCDRAGHQWGACRKPVSTPATAAPVPGASTSTSTTGFRVAGKNGKHGGPAALNSRASGTNMIQLGPRANPAGAATGNKDDANDDDGGGESVASTEPEGGDTGKETLTRATTGPTKETQTTTAAPVSTPTSPSPSASAPASPLSGGTSESSATSTTSIASTSPRRLRSSSAPGNRRVTRAGSAMILGASGGDGSGGNSSGVNQVKIIRYLKTLRPAPAAILLQEHHLGYNASREGFESAWPGACIRFTPHVLTLIPDGSPLAGHLLSSTPVVFAGAPRFDGRILRSVFRLEELDVEIINMYAPVQEDDRRDFFGLLHFNAPRPKTLRILAGDLNDCPDVSVDRVSITDRAWTPVSHWQTLLSKIAFKALDTVRHVHSCTPAFTRPHYRGRGEERKICSWSRIDYILVQCSWANRLLSASTLFDAPCSDHRPVVATFALPTSNADAEPPLSLPSTSDFISRLNPTVFDDQDFVASIPGVVDEVYRRLEGTAPLGDVYDAALRAVAVAGHARYRSTRADMRRLRAESQSVMEALEARGEHMNEAERDAYAFAKSRLDQLAVKEAQWLRIRAHVPSVDSREGQSASIRTRLNRRSRQTSIVSLEDVDGTETVDMQEALGIASRHAQSLFTPDPARGDPTNARRSLLDPIRAAKCYDDDRSDPTFGRRLPRQARVALDEPFTLLEVEAALKKTDSGRSPGPSGIPYELFKALPTYFAPKLLDLFNSIWEGGKMTASLAEGLVRLLPKNKPGANLKSLGAYRPITLRETTYKVLSKVLVARLNGVLGELLPPAQHGFMPSRRSADAGSHLTLLLEKLKSLGTEVFPEGALLSLDQQSAYDRVDHAWIFDVFEAFGFGERFISLLRALYDPETLGVRYLINGFPTELVRLLCGLGQGDPLSCPVWNITFQPFLDALVRRGIALDLQKVWPGGPRAQLTHLAFADDAVVVVESPAALSKLETLSQTWYEATNGKTNTDKTLVLPLGPNWLRDETAQALPTVQEGESFKWCGYAFFRHGDSKLFWTHVLDRIKAKTRAAGDRTLSPSGKVFYANAHIISTVLHVLSFDIPPQWFIKAAETALTDFVWGGAGRNTVARDFVFQAREDGGLGLISIGDIVHSVALRFWDAVAGSNEAIWAPLARESWRSLVAATRDFSPWGFFSSTARVEKLYRDSTRWGAVVAAARVTVPTIKSELLTLPELLSLPPRLPSLYAEGAKHAYDDADAVAKFAQIAELYWRDEGKGWALVGHRRGFWQHSKEPALQHEHVWSRVGQLLKAKALLPKTALRPARIPLKEAPRPRCFNFFGLTRPFTIRKLRRLVNVVRFPGREDRVKRFRDGTSQSDRKRFWRWLHDRFASAVEQDTHWRLMYDVTPTRKRQHTQGHASSPTCLFCGNDAAVIETVSHYFFECAYSTSFWGGVLRILFDKLGIEDTDVDPSTFTPEQLTMGLPLLRGRGRTTSRWMWVRLACAIGFQRLHLLRWRVHQRFELDKVVAPPSLPSALRAFERDFLSRAGFVPGARDWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NUN2</accession>
    <name>A0A2X0NUN2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C013g07397 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C013g07397</name>
        <name evidence="3" type="ORF">BQ5605_C013G07397</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0NUN2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1268"/>
            <end position="1553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="651"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="712"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1840"/>
            <end position="1912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="480"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="713"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY15542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1912" mass="211416" checksum="9E4A62271CFE40C5" modified="2018-09-12" version="1">MQTGDPGSAPGARAPPPPASAPTSLPIAGTKETQATQVAGRTATYAAATNSSVVSNETPAQQQDRLARLQALPGILAAIQAVPGNRADRFVQAIFATPDFPSTVATALKFSALNATRNIINPFANALEVSLSHKSTGRASATDKGELVACVRTLLSPNTPICFDTGVPLSGDLEAFMPRITGLQHSSTFRTGVLHHRITVGFVSAEARDAALASAPMLVWNSANARFAKAHPFHRNMLEMRINVGVVRPPSKEQIVAAFHSIVQQLSTKGHSCQLVQVLRVIHVDTAKAYAHTVGDFSAFIHFDDASLFQHPTTTLKEILPSRMDLPTRGLDVTAVRHDYEKEAPCARCHFAGHVERCPLMQAANRKEAEDLARHAVMRGAGMVGGGEQTGVGRAATTTTNNIRPTANNNNTSEVVAPSRALGTDQLESRNRFAGLEVEGGQEDDIEEEVAGKEGEEKEQVEEGDEDTGAKADDEDSDSDGNAGAGINKAGGDGKDNDKDNDEHDDKDEQDDSSEGSERRGDDVMKDGAEEEDEEMETEVEEEVEQEQGVQDDSIMIIDDGQTTITTVSRESTPRSPSWPPLSPETLAKSLREGAEWDRANAEAAARVQAENEAIINAQLDAQEPLVRHQFAEWGQEDGQLRFINIRGTGSRSNKKMKRSQTVADLSDPSDDPVDVKRVLNRVKGRAGKEVAGQGKRVTRSMSAAAAMQVEGAKAKAEKGKGVEEEKRWSDHEPEDDILPEFPLFEDNITAKSTWNVRRCMGIPEKRRDIYTYLSTFKASAILLQEHFIKPELWQCIKDEYEGKAFISKHCLTLIPADSPLIDAEILRTHSALDGRILVTSFRLRGDIRILEINNLYAPVDTKQRLTFFDKLHFHRTQSTHLRLLGGDLNDCPLPAIDRRNQGRHGHHWPILIGKLDSPYTDCIRFKHPLTPSFTRPNIVRKRPKSFSRLDYFLLQRTHQKRLVQASTIYDHPKDLSDHRPVSIVLVLSDERGDAAQPNNSLPTTSNQLHRINAATFKTAGFQGMLEGWLEGASGEEPVGELEVVLGNCEKEGRELARREHRERVERMAVLVGRVQDLEALPVMGDEETAEWTRTTEELRRAVNERARQLRIRAHVPEIATEERLSRPVHAKLAARSSDSKITALRLPNGELTHDIDVALDHTQAHFQRLYNLEPRDRDHVERLRDDFLAPIRSARTCDDPSSDPLFLRRLSEAHIELLQQPITEDEVVAAIATTHPGRSPGPSGVPYELYHTAPRAWAKALSRAFNAMTERGSLSPRQGQGLVRLLFKHHKIGADRAELSSYRPITLRECDYKLFTKVYVARLNHVLPDLLPPQQHGFVKGRRSADASFHLRLLIEELGARGTEFPDAALLSLDQSSAYDLVEHEWIFAIFDALGAPATFQRVLRMLYSGDSTTARYIINGFLTPPVRLTCGLGQGDPASSSVWDVVFQPFLDALHRRGVALNLSLPTIHPYPQSRAITSLAFADDVVVAVAGSESLTLLDDLALDWRLATNGRLNTDKTVVLPIGCRWEAGDRPLVVKAEGESLEWIGLSFDPTGNTELANVNLVARLEAVLDSARDRGLTHHTRAFYVNRYAIPKILHILSADIPPLEVVKELDRILVDFVRGGKRRSCYGKDVVFTPRFKGGLGVMRMQDVVDSVAARVWDVLLGGSDAIWQGLARAAIVRAHPAPDFDLATDAWPCDYTPIRTDLHPRWQAVLKVPSTHNAQVKPRTLTLANLLALPIKLHTLHYLPGAPAVSRSPYDADYAAFANYAKVADLFRRELYPGGGFHLWTPPTDVVVSNSEYDQRGRPQREHIVAWYRHAINRLRFTPIAQPVAAVRINGPPRVRPRSDGRQRPLQKTLTTRGGGDQAEGRSTGRRQATEGQPRRGRGCEARSKSSISDFIANEIENEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NWK4</accession>
    <name>A0A2X0NWK4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CDP-diacylglycerol--serine O-phosphatidyltransferase</fullName>
            <ecNumber evidence="4">2.7.8.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phosphatidylserine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">BQ5605_C012g06901</name>
        <name evidence="19" type="ORF">BQ5605_C012G06901</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16913"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="16">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.8" evidence="4"/>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NWK4"/>
    <dbReference type="STRING" id="796604.A0A2X0NWK4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003882">
        <property type="term" value="F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006659">
        <property type="term" value="P:phosphatidylserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000022">
        <property type="entry name" value="CDP-diacylglycerol--serine O-phosphatidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF61">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="10"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00060701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="SGY16544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="316" mass="33131" checksum="2DEF72E636BACBD9" modified="2018-09-12" version="1">MPGTNPELTSPPVTGSSTSVSSKVAAPIPAAGGRAATHALASRRESVTVQDSLANSGSGSGSGSGSGSGSGAASFSSSPEEKKHALKEFAEDGRHFSLVRNFRLADIVTLGNGFCGALSIFSSAKYLLTADRTYLWSVHRKASAIMHALWYPVGGFIFDAFDGKVARWRNESSMLGQELDSLADSISFGVAPAVAAFCIGLRTPADTFVLTTFICAGIARLARFNATVALVPKDDTGKSKYFEGLPIPSSLFLVGVMAYLVKNGMIDGPGGRGAGLPGGIIMPLREAFGIDLHYAAIVWFVWAMMMVSKTLRIPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NWZ7</accession>
    <name>A0A2X0NWZ7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C002g01714 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C002g01714</name>
        <name evidence="4" type="ORF">BQ5605_C002G01714</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY35010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NWZ7"/>
    <dbReference type="STRING" id="796604.A0A2X0NWZ7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015997754" evidence="3">
        <location>
            <begin position="19"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY35010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="442" mass="46427" checksum="5C1536C36E9CA8F5" modified="2018-09-12" version="1">MTRVTYFALATVVAATLAASMKLPLCAYPCPESVYKTLSDSYRDGLAQCYDTQKCNVIDKSHANTFQDALCSLGRAAKGQTHASEPSTPVSKKGESKAPGGGQGHEGGSTFNTFSSKKSKEQHEVNKLPQNPERRPSDEKHIANEHPSISQNGTARPSSQTGNSVEHAVQSSLVNATTHPHHSPSSTGHEGQHSKVGDPHEHPLSALEHVQKLTPPETPIPLRKTDKQHQTSGHTSPTHQSPPIENPSSKKRPTEAKPTPKSEQRHNTDKPPSETKKIDALPPTGKMETSSGKETTKAPAQTHENAPAQPGKEKTKAPTQIHKNAPAQTSKKAPVGDGPTTGKNGTGSSDPTKKPVQALPGSSAPQNQSAGSKPRPTSNPAGNSESLQVQTPNNTNGGPGTTGGQSSPSPPPPSRGAPAYILGSWTCLITLGTVIGAAWTMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NZI2</accession>
    <name>A0A2X0NZI2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C016g08171 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C016g08171</name>
        <name evidence="2" type="ORF">BQ5605_C016G08171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY20936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NZI2"/>
    <dbReference type="STRING" id="796604.A0A2X0NZI2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635:SF196">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="68"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY20936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="279" mass="30911" checksum="A2F2096551FE2467" modified="2018-09-12" version="1">MLLTSTRRQSEPCWRARLLADGLHGDRADPTPTAGVRPALIFRGIGTNITEVQCLMDPGLPGSTPVSGMLAVMDFEKAYDRLSHPYLDAVLCAVGLGPKARQWYRATYTNQSASIFLNGWLSATFDILSGVRQGDPLAPSLFVLAIEVFACQIRLRVKGIDIAGLQNVRELLFADDACCALHNLSDLDHLNRAIELYERASASKLSNVKSFLYPLGAFRDRSIAPDLGTWRLSDSQFRYLGIQVGVEIAEDAGWEDVKALTIARIRSIPMYYCKNVLMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P023</accession>
    <name>A0A2X0P023_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Altered inheritance of mitochondria protein 41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C019g08953</name>
        <name evidence="1" type="synonym">AIM41</name>
        <name evidence="2" type="ORF">BQ5605_C019G08953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM41 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY23591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P023"/>
    <dbReference type="STRING" id="796604.A0A2X0P023"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016884">
        <property type="term" value="F:carbon-nitrogen ligase activity, with glutamine as amido-N-donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.10">
        <property type="entry name" value="Uncharacterised protein YqeY/AIM41 PF09424, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019004">
        <property type="entry name" value="YqeY/Aim41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042184">
        <property type="entry name" value="YqeY/Aim41_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 41, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 41, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09424">
        <property type="entry name" value="YqeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="GatB/YqeY motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY23591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="208" mass="22531" checksum="5EFA065AC4FC8372" modified="2018-09-12" version="1">MLNPTRAFRSTTLNCTPTRTTRLSPILLLTLRSQSTSSAAATPGAAPTLDVTLRQALKGYMKSRQTFESGVIKSILADLQTTSHLASPPNPQKVLLKSIKTRLEAASQFTTSIPPRQDLADQYTREAQLLQKFVQNTEDALSGMGEEELKGVIKSALEEIKVEKGGEEVGVKDLGRVIKVVLAKTKGKMGGKGVSEAVKKYFDAQVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P0C2</accession>
    <name>A0A2X0P0C2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C001g00541</name>
        <name evidence="11" type="ORF">BQ5605_C001G00541</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY47543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0P0C2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967:SF57">
        <property type="entry name" value="AUXILIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="69"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="364"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="452"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="471"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="512"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="544"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="600"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="658"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="705"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="733"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="746"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="789"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="841"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="899"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="912"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="949"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1050"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1113"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1128"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1159"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1174"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1202"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1216"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1254"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1276"/>
            <end position="1287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY47543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1287" mass="136016" checksum="76E7323836865CFC" modified="2018-09-12" version="1">MAAYQPPSLFASTSNRSSYVPRAVVAPATSAHPHAGGGLPQFVPPTQASNVPPGTLPPGTIVRVGEYEVKVDRFLSEGGFAHVYLATSASPIPAGSSNATTKHVLKRMAVPDTKGVHEVGKEVQVMKLVRNHPKIVNIIEASVADLPGGTNGSKGYEIYILMEWCAGGGIIDLMNTRLQNRLTETEILKIFSDTVEAVAHMHYQNPPLIHRDLKVENILLSPPQTFKLCDFGSTTKPLPKDKVPTAVEGLQALELEINTTTTLQYRAPELVDVWSRKGFDEKIDIWALGVFLYKLCYYTTPFEEHGPLAILSAQYKIPHYPAYSNSIKGLIGGLLQENVAARPNIYQVHEQVCRLRGTAVRLENKYAKSSRPPSTKPSANLGFASVMSSSPPAPNPSGPNLAETISPMRRGRPTKTGGTVAALAKNAEERSTPPSASPAPKNLGREWDPVGITSNGDKASSSGDANGFGDSFTSIEANGSSSGFGDSFQPTSPSAAEMSPALTPSFSSTAFSKPSEASSAKSPTSPPPIGLKSPLLASAEAVLNDQSWRTRPVSSTSARNLPTSPASTVTGTKAVEAPVAAVDERERFESTYPDLDGLESFTSSGTKVASLSKNGAYSSASPAGSVTSPPPTATSAQLTGEGDTGPPLPRRPPTSSTQNAPTTSLKPSGSIRMQNRPDFTSRSSQTFLHLGNDQPLSGPKAMMNKPKEATNDLGRDPIALPGMARVSGPRPMSFSTGGSGSSFSSRWTPTAQSSTPVVASPNQAPVDLLGDDEDNDDAFAPKPLHRPSATATLTPNATESLNLPPTSSSTGTNRTSIIASSDFNFEASREKFRPVKPADSPSASRPTFSSQASPNQRAETVAPTSKPKAATKDDLSTVEQRFPEAEAIGSTGPHSVANEPKEEETWQKIEEKEDESSDDEVEQVEDITIRPRLSGPRMPNERTYSSQSFKKEEEKKVVNDIEPAADQVVSPTSGYPVLPPITRMDSTSTDGGGDIDLAPALASIRKFAPVAPPKPNIPKPDFNEKEGRSAASSSSSATRSGPPILAPRPQSVNKQDQINNLVSRYEGLSSSSDPSNRKPLPPVPAGKPTTLRQTSASSGKGRPAFGAKKTSQAAVPTTTEETAPPHWSSKQASIGNFSSRFPNAEGLHKHLTGETTLNPATTATRPSTPPRSYASPSSAVNISTPSSPAFSNGTTTASGSTRPPPFKPVPPTSGPSTPQRSYALPPSSQTTAPNKPSDGEEEEERFAGVSSMKSRWESITREQSRDGGGAGSKGPGKVEKRKSWAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P137</accession>
    <name>A0A2X0P137_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C001g00951 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C001g00951</name>
        <name evidence="1" type="ORF">BQ5605_C001G00951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY51021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P137"/>
    <dbReference type="STRING" id="796604.A0A2X0P137"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY51021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="226" mass="25631" checksum="7CA4444F4ABB7D60" modified="2018-09-12" version="1">MADLKALAKKHGKYRMISPTIEFPLGELISDSWKIAEWLDINYPDAPSLFLPSSPNPVQLDSPEMDVAKAYAFVFSSGFGSSDAQWSTFFEISAEPLAALHPGDAEDTNTERGWFKSDAKLDMKDGWKFLTSTPQESLVSRAKASLLPLEALLTDRGHSYLASKDQPGFVDYVAYGRYMMMRVAVPKLCEEIWDEKKAVKEWRIRLEKKFWQGEEGFEKTLARIYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P1Y9</accession>
    <name>A0A2X0P1Y9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01578 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01578</name>
        <name evidence="2" type="ORF">BQ5605_C002G01578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY34009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P1Y9"/>
    <dbReference type="STRING" id="796604.A0A2X0P1Y9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd24163">
        <property type="entry name" value="RWDD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017359">
        <property type="entry name" value="Phi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010541">
        <property type="entry name" value="Prp3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059181">
        <property type="entry name" value="RWDD2A-B_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955">
        <property type="entry name" value="RWD DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955:SF8">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06544">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small nuclear ribonucleoprotein Prp3 C-terminal" evidence="1">
        <location>
            <begin position="188"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY34009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="320" mass="36214" checksum="6513D518700BC4D0" modified="2018-09-12" version="1">MRYSRSELEPIIDELRLVIASVIKNEEFEWDLLDEQDERDWENALGGEDAYGSSMNVSAARDGVSDGPPYDDVVLVLPEYSLCLAPEAHLRIQHASSLSSNFKPTLYAPSVSRTDHDRLSHELTSRLDELNRQGEEYPVFNLFTSLREYLALNPLTEPTRPSRPGQGVDGHHEDKFVAMRELRIKCTLLWSHHLLATGKRKKIVQWSTELGLWGISKPGYPGVIIVEGLEADADEFVHRIKQLNWKALQVRCEHISDILPTPPPEVSAPGRHEWLLRHHASLAPVLTDEIRVKEVAGMNEVAELMKQAGLEHVFKSALKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P2J6</accession>
    <name>A0A2X0P2J6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cx9C motif-containing protein 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C002g01808</name>
        <name evidence="7" type="synonym">BQ5605_C049g12460</name>
        <name evidence="6" type="ORF">BQ5605_C002G01808</name>
        <name evidence="7" type="ORF">BQ5605_C049G12460</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CMC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY35843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000111">
        <property type="protein sequence ID" value="SGZ30774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P2J6"/>
    <dbReference type="STRING" id="796604.A0A2X0P2J6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027179">
        <property type="entry name" value="CMC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15590">
        <property type="entry name" value="CX9C MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15590:SF0">
        <property type="entry name" value="CX9C MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08991">
        <property type="entry name" value="CMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY35843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGZ30774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="61" mass="7072" checksum="8393B97F9341F5BF" modified="2018-09-12" version="1">MSTCAIQDCLMAKNYQETQCQDVIDRLYQCCEKMIKQNGTSTACPKPSVVDRKLREIKERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P7D4</accession>
    <name>A0A2X0P7D4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BQ5605_C001g00916 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C001g00916</name>
        <name evidence="12" type="ORF">BQ5605_C001G00916</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY50696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P7D4"/>
    <dbReference type="STRING" id="796604.A0A2X0P7D4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051508">
        <property type="entry name" value="Mito_Carrier_Antiporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45928">
        <property type="entry name" value="RE38146P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45928:SF1">
        <property type="entry name" value="RE38146P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="10"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="155"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="255"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY50696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="364" mass="38898" checksum="4B5D28509F9DEB21" modified="2018-09-12" version="1">MASSSADIKLNPFEGFISGALAACTAVTVTNPAEVMKTRLQLDGELGGKASALGAVSASSTQAGSTTKAGIPDLKALPQDVLNPSGPKAAKAAKVYSGPIDAFQKTWKYEGIRGVQRGLGAAYTYQIALNGSRLGFYEPIRTSINSVVGYRPDQVVTWTSLMSGASSGVIGAIFGNPLFLVKARMQAYSAFNPVGAQHHYPSVAYAFRKIIRDEGPKGLVRGMDAAMLRTAMGSSVQLPAYNFAKVNLAEHGVKDGWLMYLLASTFSGSCVCAVMQPADTALTRMYNQSPNSLGPDGKPRGLLYKNPIDCLFKTWKAEGIRGLYKGTTAHLMRVAPHTIVTLVANEQFSRRWIAYKKSSIIARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P7K6</accession>
    <name>A0A2X0P7K6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C008g05034 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C008g05034</name>
        <name evidence="1" type="ORF">BQ5605_C008G05034</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P7K6"/>
    <dbReference type="STRING" id="796604.A0A2X0P7K6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY79083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="94" mass="10435" checksum="9FC55D862012D116" modified="2018-09-12" version="1">MTNLTRDLSLEHKKSAVIIDEVGNRKLGNSESKHVPQGTSTHIVAAFDDKILESNGGYLEDCQLANDVAKEYALSEENAAKLWELNEKMVGEQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P9P5</accession>
    <name>A0A2X0P9P5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C007g04552 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C007g04552</name>
        <name evidence="7" type="ORF">BQ5605_C007G04552</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY61355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P9P5"/>
    <dbReference type="STRING" id="796604.A0A2X0P9P5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="114"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="43"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="464"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="558"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="613"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="678"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="743"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="852"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="574"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="678"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="777"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY61355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="910" mass="99707" checksum="56594A29C9DAFB60" modified="2018-09-12" version="1">MASKSEEGAWSFPDDGVCDYSLDSEAAAAFLDASLSPMINFSHPTQQQRVPTTCSRASNTSGSDLARSTNVAPVPSPRDGAEPDATSMRSSQLGAYSRPPTVPEDQDHLELGQWIVGPAIGSGESGKVRLVRHRFRSDELGALKMVRKFWPDDHKPRDIFREIEILRIVHHPHIIALKDVMESTNHLYMVTDYCECGSLFDHMRDNGILDRTEIRRYFSQLISALENLFLFEDMWGVTSLKLGDLGMSTFVPSGTMLETSCGSPHYAAPEVIAVHARRIDCGDQYDGSAADVWSSGVVLYGLIARTLPFDNDNIPTLLNLIKLGDYKMHDSIQGEARDLIRQMVMKDTSRRISVSTSNLAIKEPQRLLVEEIQRHPFVDQSLLSKDLQDTQFAPSRAELNIEVIGSMISLLRLSTMQEVEKAILDPRVPNPARYIYLSLLNMKRNLQERGRASMLSFSTTSTTFSSLRRSPSAPGSLGKSTPASSKRLRHVVSMIDSSSGSPPESFRQDTSLSSYSTDREYSLIGDAGDLPSSKTARPVLKKRSISLLARRFSLGLRSSIDRSPRQPSSSYRNSGHSSFQTSSSTSATQPGSDTPLRPGVFQRSLRYSSLGRAMAGKAPPGSPTTVVTASPLLSPEGWNHSADVDPTDISARGKGLLPRKRSWLLGSGTRRLSSLFSGSGFQTSSSSPDLKATAMSAMSRGDETEMSPSLSPQLDAANPVRQPTPLSLAHSSNAAIFRASPSALSPRGTTLTPPSCAPPVTPRIPFAPVGRSIRANGPAPSAGSHSAPSAFSPAIIGIPPNPKASSYNWVDSQNRQSTFQSEEPYLFPSRTRSKEWLGLGIDTLDLTSLDINDRLQDENRGLKLENALLKREVEFKDVELEKALKESRMYRAKMMQASNLQDRRRPALPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PA03</accession>
    <name>A0A2X0PA03_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C038g11697 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C038g11697</name>
        <name evidence="1" type="ORF">BQ5605_C038G11697</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000061">
        <property type="protein sequence ID" value="SGY91792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PA03"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY91792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="81" mass="9459" checksum="B564F944F5B5F5E7" modified="2018-09-12" version="1">MLGRAALWSRARYSFLSSSYRERLFAMIRDVDRELGEALDQMTLMFPIKLSSVEMQQTMEAIWKGFRQLSTRGSTEQMTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PAW1</accession>
    <name>A0A2X0PAW1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="4 14">1.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BQ5605_C004g02685</name>
        <name evidence="16" type="ORF">BQ5605_C004G02685</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32271"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 14">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="4 14"/>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY66554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PAW1"/>
    <dbReference type="STRING" id="796604.A0A2X0PAW1"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000006">
        <property type="entry name" value="3-isopropylmalate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004429">
        <property type="entry name" value="Isopropylmalate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00169">
        <property type="entry name" value="leuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979:SF1">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12 14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5 14" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0520">NAD</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="13"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SGY66554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="387" mass="41215" checksum="4505EE548742AB53" modified="2018-09-12" version="1">MLEISVLVQPSYNIVSLPGDGIGPEVVAQAERVLETLSTHTDNQFTVKAHDFGGIAIDNHQNPLPESTLQACKDADAILLGAVGGPKWGTHPTLRPEVGLLALRKELGLYANIRPALFPAPSLVSYSPLKEHIAQGTSIVVVRELIGGIYFGDRKEAVAGATEGEDAVARDECSYSVPEIVRITRLAGYLAGLSNPPLAVHSVDKANVLATSRLWRRVVAETMEKEFPNVKVDHQLVDSAAMVICSNPRKLNGIVLTENLFGDILSDETSVIPGSLGLLPSASLGGIPDGTNKIPGMYEPIHGSAPDIAGQEIANPIGTILSVALMCRYSLGLEREAQAIEEAVRIVLDDEDKGGFGYRTKDLGGDKSTPQVGDKVVEVLKGLLQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PBJ7</accession>
    <name>A0A2X0PBJ7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-rRNA-processing protein RIX1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C004g02935</name>
        <name evidence="8" type="ORF">BQ5605_C004G02935</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RIX1/PELP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY68975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PBJ7"/>
    <dbReference type="STRING" id="796604.A0A2X0PBJ7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012583">
        <property type="entry name" value="RIX1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105:SF1">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08167">
        <property type="entry name" value="RIX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-rRNA-processing protein RIX1 N-terminal" evidence="7">
        <location>
            <begin position="66"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="814"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="739"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="838"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY68975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="862" mass="93548" checksum="32E59A0BD61CEE84" modified="2018-09-12" version="1">MDTINHILAHQLAHNDQILANHRHVTDTLTRQRAVILCEAQDGQDGPVMHRSVQRKATPYRTEHNQSDNLSVRSPGDRWNLRMASLIAPSTSSPIRAIAFELLQLTYTASTASMLHQGKHCLAIALNILASPKSDHALFVAALGLVQLVLAKSQWHPEWARDVVGAPVVQRTLNALVAAASNQLHPIIAIASLEAIITLIPLFPTALRPVAPSIHSLAIDCIGSPSELVPLGSQLFASLYLLAPKGREGLREAWRKSVESLVGTIDALIPSVTSDIFAEDEARLNHTLPSLALPPLASSSSSSSSTPLVTLDRIEILAEVLRTVLRTPTTDRVGSVPIPLGALCELSVRLLSLHAETPVKERIDPTLVQSVNSYLPRLQLVGAQLVAQTAACVGIRLAPHSHEILTTVVSTLATYAPRSPMRAMLTSTFSVLLQHLGASIDPEEGKRSLARVWRVVLEDIGAVAVEPTLVTGDVVKNGTPNTANSGRKNKKQRTYDPSEALALSGKRPHLDGMDLEIALQSLNSKSPASDAHLAMLLLIPCFLCAALNELLSHPHSHFLPPKLQLSTSRLLLYILLTYSSVTSTSFPSTSSTLPLYSSSFKTVSNTLELAFQSPDFIPSTLTCLLTLLRTTQGGGAQGTIDLASLILAQFIRAGSSTDDRIVALARQGLAWLDGVTHPLLPPTRTDTRFVRRVREERGGDVGDVHEEVVRGVEEFGLKIPVEGGEGDEMEEEGEEEEEVRLRREEKRRLQKERIEEEERQRVEKRKMEAARPKDPIFSTKAFGFNSLSTAGEGTTTTTMMTVATTMVQQDVEEEEMHVDSTPALVSATIASVRHGSDNDGDDGDSSDDDGAMPTINMESDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PCP5</accession>
    <name>A0A2X0PCP5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C105g13170 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C105g13170</name>
        <name evidence="2" type="ORF">BQ5605_C105G13170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000078">
        <property type="protein sequence ID" value="SGZ11372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="499"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ11372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1292" mass="145112" checksum="BA36DA21A9453FFE" modified="2018-09-12" version="1">MIESLTVLTFNVRSIKNAVNKSKSSVSQNPSAGPCGHLLQEHHLATTRRAKASRVLGQGLVFVSLLMSSSFDGRILRSVFRLEELDVEIINMYAPVQEDDRRDFFGLLHFNAPRPKTLRILAGDLNDCPDVSVDRVSITDRAWTPVSHWQTLLSKIAFNALDTVRHVHSCTPAFTRPHYRGRGEERKICSWSRIDYILVQCSWANRLLSASTLFDAPCSDHRPVVATFALPTDFISRLNPTVFDDQDFVASIPGVVDEVYRRLEGTAPLGDVYDAALRAVAVAGHARYRSTRADMRRLRAESQSVMEALEARGEHMNEAERDAYAFAKSRLDQLAVKEAQWLRIRAHVPSVDSREGQSASIRTRLNRRSRQTSIVSLEDVDGTETVDMQEALGIASRHAQSLFTPDPARGDPTNARRSLLDPIRAAKCYDDDRSDPTFGRRLPRQARVALDEPFTLLEVEAALKKTDSGRSPGPSGIPYELFKALPTYFAPKLLDLFNSIWEGGKMTASLAEGLVRLLPKNKPGANLKSLGAYRPITLRETTYKVLSKVLVARLNGVLGELLPPAQHGFMPSRRSADAGSHLTLLLEKLKSLGTEVFPEGALLSLDQQSAYDRVDHAWIFDVFEAFGFGERFISLLRALYDPETLGVRYLINGFPTELVRLLCGLGQGDPLSCPVWNITFQPFLDALVRRGIALDLQKVWPGGPRAQLTHLAFADDAVVVVESPAALSKLETLSQTWYEATNGKTNTDKTLVLPLGPNWLRDETAQALPTVQEGESFKWCGYAFFRHGDSKLFWTHVLDRIKAKTRAAGDRTLSPSGKVFYANAHIISTVLHVLSFDIPPQWFIKAAETALTDFVWGGAGRNTVARDFVFQAREDGGLGLISIGDIVHSVALRFWDAVAGSNEAIWAPLARESWRSLVAATRDFSPWGFFSSTARVEKLYRDSTRWGAVVAAARVTVPTIKSELLTLPELLSLPPRLPSLYAEGAKHAYDDADAVAKFAQIADLYWRDEGKGWALVGHRRGFWQHSKEPALQHEHVWSRVGQLLKAKALLPKTALRPARIPLKEAPRPRCFNFFGLTRPFTIRKLRRLVNVVRFPGREDRVKRFRDGTSQSDRKRFWRWLHDRFASAVEQDTHWRLMYDVTPTRKRQHTQGHASSPTCLFCGNDAAVIETVSHYFFECAYSTSFWGGVLRILFDKLGIEDTDVDPSTFTPEQLTMGLPLLRGRGRTTSRWMWVRLACAIGFQRLHLLRWRVHQRFELDKVVAPPSLPSALRAFERDFLSRAGFVPGARDWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PCU4</accession>
    <name>A0A2X0PCU4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C005g03437 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C005g03437</name>
        <name evidence="1" type="ORF">BQ5605_C005G03437</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY75679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PCU4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY75679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="54" mass="6320" checksum="834266A43275C4FC" modified="2018-09-12" version="1">MMILHTKLLRIWQELKADECDPLTRLPGRPGPARWPIECWGRQVSDVGVFYLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PD09</accession>
    <name>A0A2X0PD09_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C005g03618 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C005g03618</name>
        <name evidence="9" type="ORF">BQ5605_C005G03618</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PD09"/>
    <dbReference type="STRING" id="796604.A0A2X0PD09"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000014">
        <property type="entry name" value="DNA mismatch repair protein Mlh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000109">
        <property type="entry name" value="Related to MLH1-DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032189">
        <property type="entry name" value="Mlh1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF12">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16413">
        <property type="entry name" value="Mlh1_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016144161" evidence="7">
        <location>
            <begin position="27"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="8">
        <location>
            <begin position="256"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="385"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="755"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="451"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="497"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="516"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY77374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="847" mass="93120" checksum="70EFF0FFCD646AB7" modified="2018-09-12" version="1">MSSAKAGALVSCSGAVLCILLSVADAGRWLAGAPPPPKVITKLAEDVVNRIAAGEIIQRPANALKELIENALDAGSTSIRITVKDGGIKLFQIQDNGSGIRKADLPILCERFTTSKLKAFDDLSRLGTYGFRGEALASISHVAHISVTTKTRDDACAWKASYSDGVMIPVKAGATSNEPVPCAGNDGTLIVVEDLFYNVPMRLKALRSSSDEYMHIVAVVLQYSIHNAGVAMVCKKASSANPEVNTPVGATVLDNIGLHYGEHVKRELVELDLKDEELGIKVKGWLSGPNYGVKKGTFLFFINHRLVKCSSLKQALEAFYAALLAKGSHPFVYLSLEISPSRVDVNVHPTKSEVGFEDEDEVVKIICDAVADKFAASNESRSFQIQTLLPGASRPSDGPSTSTRDQGGSNNAGHSSPSTSIRKVAPKSMIRTDYKTRTLDSMFEPVPSPLHDQDKGSGKGRAMEVDDNGDQVIDPGRGDENEDQPPVSSKRKRMMGAEEDETEDDDDIVIEEEPRSISTTRPELQKATSVKIPQSQTTLRSIRELRQEVLDRADKDLDAIVKGHIFVGVADLKLHLSLIQHRTKLYSVNHAALSEELFYQLALRQFGQFARIDLQPPVPLRDMIKLAVESDEGREAAQMPAEEIVERLYDTIHQRRAMLEEYFALSISVEGMIESLPLIIPGFLPNLVKLPLCESSCSQYEPDPSTDLILLFLSDKVLLRSGVVVDWEDEKPCFESFLRELAFFYIPGPSAPEFDDNVAASESDPSTADEHRPAPSGRTEAQEKEEKRALQHIVWPVAKQYLVAPDHLKKRDVVQLTSMENLFKVREVLILVALMMQSSKKCDRKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PDR8</accession>
    <name>A0A2X0PDR8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C005g03727 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C005g03727</name>
        <name evidence="2" type="ORF">BQ5605_C005G03727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PDR8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY77793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="101" mass="10555" checksum="21E5E4A17F0EB3EC" modified="2018-09-12" version="1">MVADVFTKALGPKIFGTHCYALGLRTRHPRIKSTSHSRGGGPGASRTDLCARSEPGASARDLGARSEPGASGRDLGARSEPGEMARDLGARNEPGLLELIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PFD7</accession>
    <name>A0A2X0PFD7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C009g05459 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C009g05459</name>
        <name evidence="1" type="ORF">BQ5605_C009G05459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY81104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PFD7"/>
    <dbReference type="STRING" id="796604.A0A2X0PFD7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY81104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="178" mass="19700" checksum="3801694D253C83A2" modified="2018-09-12" version="1">MVRAHRVIGALIIGEPAPRDLSLCQHPSCYFSPSTRFEGVQTHRPKLFNSNWSSLKRVLDIILRLAREDGAESSSRINDWIAEQLLNTCLVRVQADSIIIKEMKRTKCAFVVSHDLAPEVLASDYIDARLDAIAEDSSQSVHTLGPEYIACTRVGVSRQTRLVIGSSYATDCALSSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PHU2</accession>
    <name>A0A2X0PHU2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C034g11356 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C034g11356</name>
        <name evidence="3" type="ORF">BQ5605_C034G11356</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000065">
        <property type="protein sequence ID" value="SGZ00551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1096"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1693"/>
            <end position="1719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="356"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="463"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ00551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1902" mass="208641" checksum="38C855F3140CF50F" modified="2018-09-12" version="1">MPDPPGPHPHPPNAPWAGDVLRDESLNTETRETVTGGTVNPPAWSAQASQARLDHEKSMQKAFKALGIVPSSKSTRRLMVLLYDPSSPPSQAPALARAAQRAVRNDAMPASNVIRVIMDGTGSPRGPVQIALRKHFGLAETPFMFARPEGAELDPEVEKLFSKCVKLNPIVTKATKRFPIARHMYELVFESDQACLEAAAAGPFPYHGKEMVTELPSVSPLNHIVQVRFTLPSSSSAIPASVLRKSLDAALTSSFGHAGCTQGYTLMQLQRGLAVDPNGDPMAMTEDGFHCAYLRLHADLFQGSTETQKAALNAALPQEIEILGAKYGLRHEFETHYCAVCDRAGHRWGACRKPVSTPATAAPVPGASTSTSTSTSTSTSTSTTGFRVAGKNGKHGGPAALNSRASGTNMIQLGPRANPAGSATGNKDDANDGDGDDDDDDGESVASTEPEGGDTGKETLTRATTGPTKETQTTTAAPVSTPTSPSPSTSAPASPLSGGTSESSATSTTSIASTSPRRLRSSSAPGNRRVTRAGSAMIHGASGGDDSGGNSSGGYRSESLTVLTFNVRSIKNAVNQVKIIRYLKTLRPAPAAILLQEHHLSYNALRERFESAWPGACIRFAPHVLTLIPDGSPLAGRLLSSTPVVFAEAPQFDGRILRSVFRLEELDIEIINMYAPVKGEERRDFYGLLHFTAPGPKTLRILAGDLNDCPDVSVDRVAITDRAWTPVSHWQTLLSKIAFNPLDTIRQLHPITPAFTRPHYLGRGDKREICSWSRIDYILVQRSWANRLLSASTLFDAPCSDHRPVVATFALPTSNAADAEPPPALPTTSEFISRLNPTVFNDQDFVDSIPGVVDEVYRRLEGTAPLGDVYDAALRAVAAAGHARYRSTRADMRRLRAENQSVMEALEARGEHMNEAERDAYALAKSQLDQLAVKEAQWLRIRAHVPSVDSREGQSASIRTRLNRRSRQTSIVSLEDVDGTETVDMQEALGIASRHAQSLFTPDPARGDPTNARRSRLDPIRAAKCYDDDRSDPTFGRRLPLQARVALDEPFNLSEVKAALKKTDSGRSPGPSGIPYELFKALPTYFAPKLLDLFNSIWEGGKMTASLAEGLVRLLPKNKPGANLKSLGAYRPITLRETTYKVLSKVLVARLNGVLGELLPPAQHGFMPSRRSADAGSHLTLLLEKLRSLGTDVFPEGALLSLDQQSAYDRVDHAWIFDVFEAFGFGERFISLLRALYDPETLGVRYLVNGFPTDLVRLLCGLGQGDPLSCPVWNITFQPFLDALVRRGIALDLQKGWPGGPRAQLTHLAFADDAVVVVESPAALSKLETLSQTWYEATNGKTNTDKTLVLPLGPNWLRDETAQALPTVQEGESFKWCGYAFFRHGDSKLFWTHVLDRIKAKARAARDRTLSPSGRVFYANAHITSTVLHVLSFDIPPQWFIQAAETALTDFVWGGPRRNTVAREFVFQAREDGGLGLISIGDIVHSVALRFWDAVAGSDEAIWAPLARESWRSLVAATRDFSPWGFFSSTARVEKLYRDSARWGAVVAAARVTLPTIKSELLTLPELLSLPPRLPSLYAEGAKHAYDDADAVAKFAQIADLYWRDEGKGWALVGHRRGFWQHSKEPALRHEHVWARVGQKLKAKALLPKTAVRPARIPLKEDPHPRCFNFFGLTRPFTIRKLRRLVNTVRFPGKDGQDRALPGGQPQEPRVRRFPEGTSQSGRQRFWSWLHDRFASAAEQDTHWRLMYDVTPTRKKQHVQGHASSPSCLFCGNDAAVIETVSHYFFGCAYSASYWSGVLRILFDKLGIEDTDVDPSTFTQEQLTMGLPLLRGRGRTTSKWMWVRLACAIGFQRLHLLRWHVHQRFEKDRVVAPPSIPSALRAFNRDYLSRAGFVPGARDWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PHY1</accession>
    <name>A0A2X0PHY1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C031g10951 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C031g10951</name>
        <name evidence="2" type="ORF">BQ5605_C031G10951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000068">
        <property type="protein sequence ID" value="SGZ06544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0PHY1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1169"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1286"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1410"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1696"/>
            <end position="1729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="530"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="723"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="757"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="810"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="827"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="844"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="867"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="900"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="956"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1175"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1195"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1222"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1256"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1410"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1696"/>
            <end position="1718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ06544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1825" mass="191254" checksum="39C5665EA7D91E5F" modified="2018-09-12" version="1">MQDDETLARSELVILEELSSKHSLITSSTKEKEGLVSRGEKGDLVIGLKKEEEVVGKVLHESRDDDDDDDTTVVRAQRGTTSGIEDAGEQQMESTTFVPTATTSTGTETTEGITATPPPPPTAAVAAESSPASSSHPTPTTTITPVPSQPLPPPLSKSPAPGSSTTTTKKFQSSLLVNKKFLEKAGDKTKPTSSTGSASPELKPNQIRPSPSTLNATTSSATATSAGLPRLLSGKISLTMGSASNSSSNSSPLGNKNSSSSSSAAGGTGSGGAATQPTTTWTKTPVPAQPLPTPTSAPGGLTSEDRAFGRRPPSAFSSTSGGRTDQPWVRGAPRSLDFGATEFPTAAEAANAKALRAQQILEQMQSRDRAIQARAAAAAKANAHLLEGLDAFRGVHLDPNASHWDEMGDEDDNFLDDTIEFADGTQYKISEVAAANNNTNELKEPSPEEMGKLEAPLAPGEKMEEPSRQERFKDDFDRSYGGSRAANDSSSRREPTHTSTVSNANGPSGAPPTRTLFNAKEGRMEPTAPSSSSRSSGPSTRRLSNDVVSIARRGDITSPRLEKASLPPAPATNPWGRVPPTNAVPISTTARRLSMNAGGERQLPPHMMQANQHPSVAQTRNSVLSPPRAREPSLPSTSPSAPAPAPAPVQAPALKEAIAPPPVLEPVEDLEARQAREMHAAAERARVRRQEEERERVAQAERAKKKAQELEERMKAAEEAKKAPVVVQKEVPPSQAAPKVDTWRRTLDPTAPAGTLTAPSKTTATPPVVTSPPSVRTEPIRILSREPKESAPPPHVAITKASSVPPVNESKPTSSATNSTARAPLEPQDRAWRRADVSNGRGNVPPPPTTGYRQPPPHLLAQAANANKHEARVSERERRVSGNAASSSATMEANLEIKLASSNKTTPPQASPSSATGVETITSPRRGNRGQQQQQQQQRENAQFDDLMSRVKNAMASPSSKDGSAEASPTTTMTGQDAPETVVTGSSPPRVKMPVIKLPSSGQNKQAAFASVANSTTIPAATPSGRYNQASVRLPAQPAATPAAPPKPAFELREPRSMFERTARARSPSPGPAWRLYPVKLASYPTARRPVSRYKLRDFNDAMKPLRVALLTWNPPIQGLGTRRLSRDDYLHPKKFTRGIPQAAVQMPKQRIERRTEIEIVIVDRSKPKPAAVNGSRSMGESSRSATPSAFERGWGSGSPAGAGAGRVRPSDAEHWKRATPSKVNGVSSVDTTTAPSTAALFDPATPQRLTPPPSSAQSASQSDSLPSTSKPFLSQVSAAVSAVAASDRTRAVTGDLDGEEVQKTPRASLSAPGAERMEPTSLDKAKASFDATSSRVMPAATSSPWPVGKAPLSLSALDPTASSLWAAPPSEPGSHVRSMSLPRTRIENSLKGLGDDDYPSSIPMSLAELKSEDEGSPERTKGAQLPESSTPVPNNEPKLRAAAPSFSSFHTEHFAAHQSPGSQNPSTLRFSSIQRSVATPSHGVEAYAYSPQLSAATLVGHSYSPAHYATGAPQHYASYSPVQQHQQLSQAQQAHYQGRTTYVPTSAASLYASGVAASEYASVPTTTAHQQQQAYYRAQAAASAQQQQQSQQYLVNPALVAAGYGTSSYGSDAVGAYGAVGGGASRHVSSHGGVSAASTAGGIYAAHPAYGVSPVSRSSMYSPIPSSNRVYVSSNASSHYSHDLPRNDVISSSSYYGSTATPSSTTTTSSTSPYSHSRTIDSALSSGTPATGSSFISGPISPVIMPQHLQPHAVHLVPSGSIGSAFPSTAGAGNRGANAGAAQGGRGGYGGISSSGARAVSANVGGVHGGYQGHQQAGTYRSQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PIW2</accession>
    <name>A0A2X0PIW2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C030g10784 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C030g10784</name>
        <name evidence="3" type="ORF">BQ5605_C030G10784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIX23 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000069">
        <property type="protein sequence ID" value="SGZ08308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PIW2"/>
    <dbReference type="STRING" id="796604.A0A2X0PIW2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019171">
        <property type="entry name" value="MIX23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31905">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31905:SF2">
        <property type="entry name" value="PROTEIN MIX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09774">
        <property type="entry name" value="MIX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ08308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="213" mass="23640" checksum="A7A48E5087EB4349" modified="2018-09-12" version="1">MSSSSSSPPSPLLGTPYILAQSTPTSSQTHLTQITPSLCSNLSAFKALLRSSRALDDSIALRLNRVSALHRSFSNPDGDSCDSFWNELTTRWNERTRVLAFCDQVHLDQARTLPIPTADSTRIEKGLDHDRLTTQGRGETEVEVKRRQLRTETNVEAIIRARSLDLFLSRCPYHPQQPAPMPLPGYTTDNSLTPGDAVARRGRDGRGRVNWNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PJN5</accession>
    <name>A0A2X0PJN5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C061g12739 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C061g12739</name>
        <name evidence="3" type="ORF">BQ5605_C061G12739</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000137">
        <property type="protein sequence ID" value="SGZ35470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0PJN5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="766"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ35470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1581" mass="177718" checksum="44DA8242E5E1CE67" modified="2018-09-12" version="1">MSPVASKRSKKNASPTRATNNSPRVYPARSQSSTPTASALCGFIVAANPIRKSGRPTWPKRRRGARSGSRGRRGRDERSRGTAGTTAGGAAVGGLRICRICRTAERRGTRREHTETSDAEEGESQSAETGSMPEVVSTTPELTRFRSASHHQLDMDGLPDDWMNRVSDRERKQDAGLYDEITELDRTPSVTGWMPSPSPGPVCDPEPEPKQEVEEGTSQGLRRSERIQRLTSVARTSDWNESTAADPSFGPMLSIKGAAAARSAIVMIHHHDLNRGFNTPERRRLLLSYLTSLTPPSSFSRNIMFLKHRQSHIATMYAQSPQGEAYFSQHCLTLIPSSSFLFRWSIVPARVQVSWRAAYFRDHLRCAGFDGRRRTQQYYAPVQPAERLLFFTSPSLRATVDRPNTHHWLCLCLGLDGAYTDPFGSCTHCRPATTRPASQQGWPAHFAARIDFVGAAATRATDRSASTLYNISRPMSDHRPVMVTFRLRASGAEVEEELCLPQAAHFLTRINSSTFKHAEFKEFVTPLLEQAPSGDPVADLQRVLSESRVQALELSRRLFRERNALEMMLVSRLQDIESRRVLSPFDIIDWTNTHDALSKLVNERARQSRIRAHVPEIASEERLSRPVHAKLAARSRDVKFQSIRLADGELTTDMERTLEHTHSHFQQHYLVEAKDPEQVVTMRDELLGPIRSARPCDDPLSDARFLRRFSNSHVDILAEPISEAEVLAAIRTTHEGRSPGPSGVPYEMYRACPLLWAPLLTRAYNELITRGSLTPQQSQANVRLLFKHNKPGAARCDLKSYRPITLRECDYKIFTKVYVARLNRILPDVLPAGQHGFVKGRRPADAALHLRLLIDEIRGRGAEFPTAALLSLDQSSAYDMVEHDWVFAVFEALGAPEPFQRVLRMLYNGETSTARYIVNGFLTETVRLLCGLGQGDPLSSSVWDVVFQPFLDSLSRRNIALTITLPELAHRPQTRCITNLAFADDAVVAVAGPEAIASLEALARDWRLATNGRLNTDKTVVMPLGATLWDRADLSKLSFVAPDESLPWIGLQFAPDGNNRLGFHDLERRVDRVILSVRDRWMTHHTRAFYLNRYGISKVLHSLSADIPPSDVIKSIERKLADFVKGGPRRSDYKQSVVFTARARGGLSVVSIQDVVDSVSVRIWDVLAGGSTAIWGDLARSSIRRALPTFDFAADLWTWRNADAPRELHPRWRAVLSVAERYPAVVDPAKLSVSNLLSLSPLQPGLHDSRAFSEQDKRLAKHFSFERTIADIYARAQYPAAPTVPWTPEKHPQGDGSELSNLWQWKRDQVQAWIQVAGDRFIPPLPPPVLARRPPVIRVVGAPGARAGGPLEHILPRATPVGMPDQRLPLPSAPLLANQWRMLSLDRPYTIARLRRVINHRRFDDTQRPGSLATPKERRLFWGWFHTGPATAREREVHFKLAYHFTPTRKRQFVQRHGDSACCLVQACSLAGVEDDFTHFWHDCPDSSQFWQAARSIICDALGVVSILDLDYTALQIEHGLPRLRARLPTSKKRPIRAFIALALDTLSNRRWDLHRHARAMSSMDKEMAGLKERLELRLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PK31</accession>
    <name>A0A2X0PK31_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C029g10668 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C029g10668</name>
        <name evidence="1" type="ORF">BQ5605_C029G10668</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ15404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PK31"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ15404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="438" mass="48980" checksum="33B5596550C2C7E4" modified="2018-09-12" version="1">MNVFRAMGAPERFLGLLDVICRSVSLRYIINGYLTEAVRMVCGLGQGDPAAILTHLAFADDAIVLVSSPAALDLLTGLAVDWRLATNGRSNTAKTTALPLGLGWTQDERASRDRYCARSTTLNRAKARLDAAANRRVPPRARAMYANSYVTSRVIHLLSFDIPPVTFVDAFEQALISFVWHNDSFRPVTKEAVFLRRDLGGLGLLSIEDIVCFMTIRFWDCVAHGSESIWATLARISWERTYPEETSIWSTLIASPRRATHARWTKVINVARMMLPHVFPELLRSTEVLVIPPTLPSLHPQGLSDDARKRLKKFGAIIDLYRRPQTTGDPVNPGLQPESLLEKLWADVSASSLIASVLPQPAAVRTAIGECHFLRPCTYTFLGATRPFTIKALRHFINEARHPSLDDGSRLKWPTDLTKSQKQQVWIWLNSQWATAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PL88</accession>
    <name>A0A2X0PL88_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C022g09476 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C022g09476</name>
        <name evidence="2" type="ORF">BQ5605_C022G09476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PL88"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ22341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="369" mass="40034" checksum="EA702AFF9AA0F81A" modified="2018-09-12" version="1">MAGSASEKDKENQRRNGKGTGSGSGSGSGSGSGLGSAGSGSSAQASGGLKLGPSLVRAKKYIDADGMYARKDKGNMGLRDYTCKRGKIDKIYYNWVRSVVRDALVVAGIRTPTPVQLYGPLAEINQEWSPNHDLPENYDLKDAFRLISAKTSTNTVLWGNLSPLKQREIVKYIRERAGFLAVTSGDWLYEELVIDVLANIRSAWKLAYDREVCRLAGIKGQLSKADIATLCSRHGEGPSRKSQDGVYSASDTGTSDLEEEEVLATRNRTLVPKKRGARQGAGSPQLSQETQQTSPHVGSSGQRSTPAASGVRGPGPPRNKKTKTEHNPNRSQQTKPKRDLGNGRAEEEEDEDQGQDEEEVEELERSLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PLZ1</accession>
    <name>A0A2X0PLZ1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C026g10153 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C026g10153</name>
        <name evidence="2" type="ORF">BQ5605_C026G10153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ27643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PLZ1"/>
    <dbReference type="STRING" id="796604.A0A2X0PLZ1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006994">
        <property type="entry name" value="TCF25/Rqc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684">
        <property type="entry name" value="NULP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684:SF0">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT TCF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04910">
        <property type="entry name" value="Tcf25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="739"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ27643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="761" mass="81726" checksum="5AD102F48D576FD8" modified="2018-09-12" version="1">MPPRLSKRQQREQAELDDLAASAAANTDLGDDGERASSSEKDEVGQEKHDDDTGAAAIANSGALGRTTAGFAALDLGDGDDDPDDDDDANDEPFTAIAAGTAKKGKNKKKKKKSKLSAAAAPSTTGMNDTDDSTAPVTPTVSVSTPKMASTKKKNGAKSAAGTPKGHADDLDEIDRALAELASKGGPSLAAIQAQQQNSQLDKRFETIKGVFSFDTKLLDGDAELRKFFGSKIASSRCDCTLRIQHTAPAPRSQHHARFANNPHHSTSIKRTASYLANPEPGWLPAAGVLKLETYVGSEAKNDRSRDWWTYVHTPEYKIAQMGFLEVLQQADGNRLYSILQSQPYHIDTHLQLAEMLNQQGDLTGSSQHLARALYAMSAPLPPSFTSGSFRLSYNRIENRAFFIALARNVAIQTKRGTWRTATEWAKIALGCSGGMDPMGMLCFLDFLAPKSGQNEWLLSLLEELPKVYPNQPECQVDLYPGLAYAKALCLRQLHPKETSSDSVATKALASAILRFPAVVPLLLSTLGGNVPPALISHPRAQISGSYTTDPSYLTSLLASLYAHRSSPLWKDPSLLSWLTSTASSIVSSLSDLSNPNVVFGEKAWSAQHAWKTNQAPEGIIRALYLADVPSLRPYLPPSVTSNGEAMYSYDPLPPKGPNVTYYSDDYFQVLHSTSVGKRIRQQNATRTQAQRGGAAARGFAAQLAALLGIGQAGGAIDMNDELRRELMDELAMLQGGGEVGQGGLPGGFAGFGEDTDDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PP20</accession>
    <name>A0A2X0PP20_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C045g12232 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C045g12232</name>
        <name evidence="2" type="ORF">BQ5605_C045G12232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000115">
        <property type="protein sequence ID" value="SGZ31692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PP20"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ31692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="155" mass="17348" checksum="5557A60E04E93468" modified="2018-09-12" version="1">MDPSPVNAAISQRSQGQQRRRQRERLERERSVPVPHSFPPDPAFAKSRRISPAPGDPKMIALDNPLHPSQRPMPTLSRSDDLQSGSSGSAFTYPRHDLGATDLLCRKCSAFHWDFERLGGRDTPVFRASCNDGKVELPMIKARNFCPVLQESPKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PQK6</accession>
    <name>A0A2X0PQK6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C068g12844 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C068g12844</name>
        <name evidence="25" type="ORF">BQ5605_C068G12844</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000130">
        <property type="protein sequence ID" value="SGZ35012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="567"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="834"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="23">
        <location>
            <begin position="841"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="882"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="23">
        <location>
            <begin position="909"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGZ35012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1528" mass="166592" checksum="AF4E897820E00A9F" modified="2018-09-12" version="1">MLCLAPSIFRLGPQLAPRFSLSCSSNFIGLVSLRGHLRARPRHFFFRASHGSAPPTLRTPGMSDSDVPKPTTLTVPPPRPPTQITAFAASDLLRDADGYQDWVLTLCSRMPSDVIDYLKSGVPPTSWPPAYVPLWDHYARASICAAVDPRLVLPGLSQYFGDTHSGHKIWAALRTRYGAVSAVDLLPVISRLFSPDLMPDTADAFLQFRDRFENDSRLLNDSDVTTDSLLASHLLARMPPSLSAWRTTFVNSQGTSRTLPHAAEILDRIYREIKARPIDPLAAATVTATSPQRTPPSPCPNPTCRKMHWLRDCPDTTWAAAFRARKAASGTTSRAHKKGFRTIASPAVTSPTDTERPEPTTFTACLLATPSAFPKSAWLLDSGANRHMANDSTLFSSLRPFTGPHVAGVAGSLPSTGCGSVRLSTSAGPVVATDVLLVPSLPCNLLSVRRLDRLGFTVSFGSGHAAIRNSSGTVVATARAIANDLYALNVAPSTCMPNALLATPHRVSLLTLHRRLAHLPVAQLKNVVQKGLVTGVDWVYSEEEFRSFHCNACLASKAHALPFARSKSIAPGRLALIHVDVAQMPRASFGGHRYMLVIVDDYSRKQWCLLLTYKSDVFHRLRDWILEVENATGDRVKTIRSDNGGEFTLRTFVDFCVAKGIRRELTIPYTPQQNGRVERTNRTIKEGILALLYSAGADTRLWAEAAKYFVHCKNLLPHAGIHGEVPDTRWYGMAPDVSSLRTFGCRAWHCLPSVKRTDLDPKAVPLIFVGLDDHAKAYRLFDPATRKILLSRNVVFRESEFPALQPAANTTTGATPLPVAAEVYPDQVDHSEPLLVASPRSPAPRAAPPGPAPVASDQGLRRPSPGRAVPDQDSHAPPASDQGPSPASDQGSPTASDQGSSDSAISTPCPSPRPVVPRPLPAPPSPARSESPDPIDLLPRSSDLASFCLAPEFPDDLDDALHSPPPVAYLASGAAALLNNAPPDSTELIAPARDPPHWRAAMATPQADEWRLAAQAEFDSLSRDFSAFTPIDESLVPADAKILGSRFVFRTKRDQHGQVKSYKGRLVARGDSQRSGIDFDETFAPVAKFTSIRALLALAAAHGYHVHQADIDKAYLHGKLDKPLYIRVPDGIYMPGKVLQLHRSLYGLRQAGRIWNDEIDSALSALGYAATESDHCVYVRTAGDERHYIALYVDDLLMISPSLPEIERTLQGLEQRYGVKRLGEAEYILGIQIRRSDDGSITLSQEQYLKDVLARFGMSDAHPVATPMQPDLRLEVELQPTPFPDRTRYLQAIGSLMYASTGTRPDLAYTVGYLARFSRAPSTAAWGAIKHAFRYVAGTLSHGLRFAHGASPPLVGYSDCNWGACLSSSKSTMGYNFIYAGAAVSWSSRLQSRVADSTCDAEYLGLSHAGKEAIFLRQLFGELGLSSSEPVLIYGDNQGANALTKNPVFHARTRHIRLREHFVRDMVSLGDIVIQYITTSEMTADIFTKALSRDLFARHRGRLGAGQLAPRFSLSCSSNFIGLVSLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LPB8</accession>
    <name>A0A2X0LPB8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C011g06513 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">BQ5605_C011g06629 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C011g06513</name>
        <name evidence="2" type="synonym">BQ5605_C011g06629</name>
        <name evidence="1" type="ORF">BQ5605_C011G06513</name>
        <name evidence="2" type="ORF">BQ5605_C011G06629</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LPB8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY12454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY12859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="124" mass="13813" checksum="A98D3297235908AD" modified="2018-09-12" version="1">MQRDGWIDDKIWYKPRAHHGVDVESYFTHFIAHEPSINLKEPCAGCSSANQSPTSNNWHGSYRDSDARRQLTRCLFCPVACGIKPKDDSQRMVKHSLTGDIVGAAAEVVVDAAAGFPIRLLPLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LS61</accession>
    <name>A0A2X0LS61_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitinase</fullName>
            <ecNumber evidence="4">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C012g06865</name>
        <name evidence="13" type="ORF">BQ5605_C012G06865</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="4"/>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LS61"/>
    <dbReference type="STRING" id="796604.A0A2X0LS61"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06548">
        <property type="entry name" value="GH18_chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000005">
        <property type="entry name" value="Endochitinase B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000075">
        <property type="entry name" value="Sporulation-specific chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="GH18" evidence="12">
        <location>
            <begin position="9"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGY16395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="419" mass="47363" checksum="74F81F5F891339FE" modified="2018-09-12" version="1">MSIPRPNGKVNVGYFTAWGIYARGYKPFPTVVPVESLTHILYAFAKIDSDGSVTLSDPWADEQASRRACLMLLWSLKLIGRLTLNDQIHFDGDDWNEPGNNLYGNLKQLYLLKKKNRHLKLLLSIGGWTYSPSFAEPCSTPHGRKKFVETSVKLLEDYGLDGLDIDWEYPKDDSQARDYVALLRELRLALDAHAQRKRLQQHQGYELSIAAPCGPEHFEKLRIREMDLYLSFWNLMAYDYSGSWDTNVAHQANLFNRDPQGLSTDRALRHYTSQGVSVDKLVIGIPLYGRSFCNTDGPGCPYNGVGEGSWEKGTYDYKSLPLHSSSETFDPHLVTAHCYSPSKREFVTYDNAASAQAKAEFINTNGLAGAMYWELSGDRDKGSPGNLVELVGRTMGRLDTRQNCLLYSESKWDNVRKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LS75</accession>
    <name>A0A2X0LS75_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dolichol-phosphate mannosyltransferase subunit 1</fullName>
            <ecNumber evidence="13">2.4.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BQ5605_C012g06748</name>
        <name evidence="16" type="ORF">BQ5605_C012G06748</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a di-trans,poly-cis-dolichyl phosphate + GDP-alpha-D-mannose = a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + GDP</text>
            <dbReference type="Rhea" id="RHEA:21184"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 13">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 13">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 13">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.83" evidence="13"/>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LS75"/>
    <dbReference type="STRING" id="796604.A0A2X0LS75"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006720">
        <property type="term" value="P:isoprenoid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000036">
        <property type="entry name" value="Dolichol-phosphate mannosyltransferase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398:SF1">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="15">
        <location>
            <begin position="23"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SGY16061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="245" mass="27353" checksum="CB46234BB9A37105" modified="2018-09-12" version="1">MARSLTASTSTSTSSSSSPHQYSVILPTYQERRNLPVIVYLLAKTFKQHDWAWEIIIVDDASPDGTLEVAQQLQKLYGEQHIILRPRAGKLGLGSAYVHGLKFCSGDFVPKFLPQFIAKQKIRDADVVTGTRYISGGGVYGWDLQRKVISRGANLLAKIVLWPGVSDVTGSFRLYKRPVLERLINETVSRGYVFQMEIIVRAKATGLIVDEVPITFVDRVFGESKLGGSEIVQYAQGIWMLFRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LT65</accession>
    <name>A0A2X0LT65_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C015g07753 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C015g07753</name>
        <name evidence="3" type="ORF">BQ5605_C015G07753</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LT65"/>
    <dbReference type="STRING" id="796604.A0A2X0LT65"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="524"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="525"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY17337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="630" mass="70867" checksum="CD068A6B6B6316BD" modified="2018-09-12" version="1">MLLELLRQRYLEMLRSVPSRWKVLIVDEYTRPMLKSVLSTYDILEEGVQQVDVITAPRSPQPRLAAIYLVMPTAQNVDLILRDFAPHSSPNSTSAQRSSKKREPAHLNAQAEPPRYASAYLQFLEELYLNLHALESRVFSLKSPHAFLSLFSPPGPKVDDSVARWNYEISRMSHILVNALATLGEYPVIRYYSPPSSFHGLLGPAAAAGEPMCKRLAERVQAEIDAYARDNSDFPPISDPPRPRGVLLITDRSMDLYAPFVHEFTYQAMCNDLLDIEDGRTYRYTFRNAANDVEDKEAILTEEDSVWTEVRHMHMKDALDKLIADFKAYAGEHDGKFGQSGGTSLNDMKDMLASLPQLREAKEKLSLHLTMAEKCMHLFEKKKLPSAAFVEQCCATGVTPEGKIPKTLVEEMVPLLDDRSVSSTDKLRIIALYIMHRDGVPEGDRRRLYQHARLALHEMDAVDNLSQMGINVSKDSGKKRKALFKQRPEEDSYDISRFQPALKYMLEEHIAGSLDQTTFPYVRDAPPSGGPSSSRAASVAPTQAGSLRSARPQWTATRGRRTIAELRQRVVVFVAGGMTFSEVRAVYKLSESANKDIIIGRQANDVYIARPSGERRIPNTARCTLGIPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LU24</accession>
    <name>A0A2X0LU24_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C014g07478 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C014g07478</name>
        <name evidence="4" type="ORF">BQ5605_C014G07478</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY18808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0LU24"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635:SF196">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="472"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="953"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="412"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY18808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1422" mass="156476" checksum="B46F9C355D29D43A" modified="2018-09-12" version="1">MRSYSSPFQFSDLIFKPHRRNEETPIGWTTNNNTNNASHAAIPPLRPDPPDPPGQAPATTTKSYSAAVGARSAAKHGNATANASTAVAAHPLMHNIENCVIINTPPSTSVEQVLLALDKYYPGLTGAMPCVIKGQRGLRFPKAADLDTLVANGLTVGKTLCKVEKLYSSTRGGVVQCTLTGFFSDPEGLCLFDEQIAAYGTVLRRRIQYIGKTKHISGVYDFILALKDVDVLPPASLSIARDGVTERIPLRITGGMRHCVFCRSAAHVRKDCPVAPACKSCASTSHATQHCPARHASSPQGPPTSRAPQASTATTAAPAAVSKSISPASAHDRMTKKCRVEQDLAAQTEDLPNRAQPDSLSKNARPEFSFNFPCKTATPPAPQPASNQGIAYSLSIITRSKSIDALSKPATREAPPTAPALEASEPSPEPSSPTPLPSAAPKARPDDADTDDEADEEAEDQEAPPKDSINEDRKRASLFSNLRSHNADVFLLSETGRPSPERVAQWTQECQDLKLSALFTPFNSTAILWKSDSVVITFDPESPPNTLRASFSFPDRVTDATFCVGDSKVRVVSIYAPSSDKPDKKRYLSHLSTALRQVVRDEPSPPALLVGGDWNCVESQPLDSENQNGTNYGGQEMRDLATANNLFDAYRLHHPKGRATTNRSAPGTCRRLDRIYVSPDWVDLFHDHKIWAPVLKSTHSMVVAPFQVPGAIDIGPGKFKLGLHVIEGDATCEYLTSIVRTLYNKALLQTPNDPPAAWTSTKHRLLPELQALARTFARFRRGGSEQERADHSRYGAALRSRLDPSLAGPSSIFIRLRKVRASDLIPSLTVNDVVHSDPDSMLGAASDYFERVYEDRPIDDAVLKAIIDGLASTRLSPADSLKLEEAYPLEEMTKAQAACKSNSSPGPDGLPVEFYRATWPATGPILRDVINSIPTEARQPGPLPRNTAHIHLIHKRGERDQLSNKRPISLINADERIISQAHNQRLAPLLESLIGPTQRGFVPNRWIGTNIAEVQCLMDRRLPGSTPVSGMLAVMDFEKAYDRLSHPYLDAVLCAVGLGPKARQWYRATYTNQSASIFLNGWLSATFDILSGVRQGDPLAPSLFVLAIEGFACQIRLRVKGIDIAGLQNVRELLFADDACCALHNLSDLDHLNRAIELYERASASKLSNVKSFLYPLGAFRDRSIAPDLGTWRLSDSQFRYLGIQVGVEIAEDAGWEDVKALTIARIRSIPMYDLPYAAKCSIINIYCYTKILYYSRFLPAPKSVVKEIEEAAMLAIHGRASDGTQRHPRVSRSRLCTPLDHGGFGLIDLPRRLAIDHAKWVFQLRAPDGCFTRHLFDIRIRLQAPNEPTPFTLSRPAPNQHRCPWIWIWWAYFCHPPPKWDHAVRKTTKLLPARWVRYFEAWASVTTLNPPELSKSQNLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LV54</accession>
    <name>A0A2X0LV54_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C013g07340 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C013g07340</name>
        <name evidence="3" type="ORF">BQ5605_C013G07340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0LV54"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1245"/>
            <end position="1530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="560"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY15347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2050" mass="228571" checksum="364E647C02F52A4D" modified="2018-09-12" version="1">MSTGDPGSPPPAPPPPVSATSVQPPRDQIPISSKKTQVTGPATAAPNYAAAASQATQSPEQQQQQQQRAKALGSLLQAMGAVPGNRMDRWVQAIYFAELYPVATATSLKFSALNANRSVENIFDYALEVTLSHQSASRASHADKTDLVACVTRLLSPISPICFEPGVPLPDHLAAYRPQILGVQHSSILRNGAAHHRVTVGFVTGEARDAALTTPPALTWRSAKARFAKSHRFHHNMVELRINVGVQGVPSMDAIIKSFQLLVQDLSGKGHSCQLVQVLRIISVDNASAFAHVAGDYSAFLHFDDDSLFKRPNTTLKEILPSRIGLPTRGIPVTALRHDYEKEAACGRCHFVGHVGTCGLDQESKRKEAHNGNANGNTNANKNTITNDTNIVEAEAPIPVPVVNRIASQNRFAGLEVEEGQEEAVTGQSGQGPEESGEEDAGDKADDEDSEDSEMESEATAKTEVIKLKSEDESVLEDCGGSDGEVIDEDEVMADGRGETEGKVATEMEEREVATEMEEEEVATEVDDVDEAGGATKAENAEATDLGETNRLDNDDDSDATATAATASRESTPHEPTPPLSPETLAKSLREGEEWDRIRANWVEQARLERDQSIERRLDAETPLVRHNFATWDEDGEIRSINIRGTAANDEPTDAKRVIIKGKSRVVVKDGTEGRRVTRSMSAAAAMPVGVTKVDRGKAKGVAEEKRWSDHEPEDDRFDLNYPLMIKHTIITWNVRRGMGVPEKRRDIYNYLSLFKASAILIQEHFIRPHLWQLIKDEYEGKLFINQHCLTLIPADSPLIDAELLRTHSALDGRLLVTSFRLRGDIKILEINNVYAPVDAKQRAKFFDKLLFHKTQKSHLRLLGGDLNDCPRPEVDRRNQSRRGHHWPILIGKLDSAYTDCIRYKHPITPSFTRPNPNRKRPNSFSRLDYFLLQRTHQKRLDQASTIYDYPKELSDHRPVLIVLALSDDPDATLPQLSLPTTSNQLHRINTTTFKTVEFQRMMEGWLEGASGEEPVGELEVILKACRDRGGEMARRLHRERTERMEYLVGRVQDLEAIPEWGEAETAEWTRTSEELKRAVEERARLLRIRAHVPEIASEERLSRPVHAKLAARNSDSKITALRLSNGELTHDIDVALDHTQAHFQRLYHIEPRDPDRVDRLRDEFLAPIRAARTCDDPRSDPLFLRRLSESQIDLLQRPITEDEVVAAIGTTHPGRSPGPSGVPYELYQTAPKAWAKVLTKAYNAMIERGSLSPKQGQGLVRLIFKRHKKNADRAELSSYRPITLRECDYKIFTKVYVARLNQILPDLLPPQQHGFVKDRRSADAALHLRLLIEELGARRTEFPAAALLSLDQSSAYDLVEHDWIFAIFDALGAPATFLRVLRMLYSGDSTSARYIINGFLTAPVRLTCGLGQGDPASSSVWDIVFQPFLDALHRRNIALNLSIPALHPYPQSRAMTSLAFADDVVVAVAGLESLNLLDDVALDWRHATNGRLNTDKTVVLPIGRRWDPGQRPLVVKAAGESLEWIGLPFDPSGDTELAYANLIERLEATLEGVQHRWLTHHTRAFYVNRYAIPKILHFLAADIPPPEVVKKLDDMLVDFVRGGNGRTSYGRDIVFTAKLKGGLGVIRMQDVVDAVAARIWDVLLGTPPSSARPRPGHRSLATSIHSIPNDLHPRWRAALGVPKQQDAQVNPRTLTTANLLALPTLLGSLHTPIRGRQTIDAVHIPDYLRLQGYPKVADLYRRELYAGGGFHLWTPPADVLGDNREYDRRGLPHRLAIAAWYRFTVDRHKNTPLAVAVAAGRLNVPPRIGTSAPLEAILPKPVARFAMEQRLPDPVLPQQASQYKLLNMARPYTIRRIRRVLNAKAFTNTLGLKGPPQPDDLRSFWKAVNSKALTAREREVWFKLILRFTPTRKLQHQQQHDTSPACLVCEAPVDDTDHYFFGCVDSRNVWIAARGVLCDALGCDTIEDAQYTTLQRLFGLPKLKAKLSEQEGAGRTIEMFTGMVLEMISSGRWSMQKHGTRMESVERRRVVLEERMKLRAGGARGGRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LWZ0</accession>
    <name>A0A2X0LWZ0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">BQ5605_C018g08773 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">BQ5605_C018g08773</name>
        <name evidence="17" type="ORF">BQ5605_C018G08773</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY26754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LWZ0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="16">
        <location>
            <begin position="423"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="726"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="765"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="807"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="SGY26754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="818" mass="88855" checksum="059C0ABD7F34416E" modified="2018-09-12" version="1">MPAADDTDAAGDTKSVGPATTLAVPPPCPPTQVAAFAPSDLLRDANGYQDWVLTPCSRLPSDVIDYLQSGVPHPSWPPSYVPLWDHYARASICAAVDPRMVLPGLSRYFSDAHSGHKIWMALRMRYGAVSAVDLLPVVARLFSPEPMPDSPDVFLQFRNRFDNNSRLLADSNVTTDSLLASHLLARMPPSLSAWRTTFVNSQGTSGTLPPTADILDRIYREIKARPSEAPAVAVATPQQRAPPGPCPNPKCRQLHWLADCPDTAWAAAFCARRASTGASSRGRKKGSPAVASPAVVEMPEPMTFTACLLATPSLFHKLAWLLDSSANRHMANNTGPVVATDVLLVPSLPCNLLSVWRLDRLGFSISFGSGCAKIRNSSGTVVATAQAVANDLYALDVAPSPCMPNALLATPHRVPLLTLHRRFAHLPIAQLKNIVQNGLVTGVDWVYSEEKVRSFNCNACLASKAHTLPFARSESIAFGGHCYMLVIIDDYTRKQWCILLTYKSDVFHRLRDWILAVENATGDRVKTIRSDNGGKFTLRNFVDFCLVKGIRRELTIPYTPQQNGRVERANWTIKEGIFALLYSAGADPRLWAKAARYFVHCKNLMPHAGIRGDIPDTCWHGVAPDISSLRAFGCRAWHCLPSVKRTDLDPKAMPLIFVGLDDHAKAYRLFDPVTRKIILSRNIAFRKSEFPALQPVADTPLPVAADIYPDQVDHSEPLLVAPPRSLAPRAELPGPVPAASDQGLCRPSPARDIPDQDSRAPPASDQGSPTSQAGDHFDQNSPTSCASDQGSSDSATSMPCPSLRPVAPCPLPAPPLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M054</accession>
    <name>A0A2X0M054_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C019g08945 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C019g08945</name>
        <name evidence="2" type="ORF">BQ5605_C019G08945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY23510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M054"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY23510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="125" mass="14056" checksum="D1BB15D8AE6542AE" modified="2018-09-12" version="1">MLNPPRTTRHEKRLLSATPLPPTERTSLKQFQDQLEQAHQKEAMARVQAHHHHLHSQSTVQHKLAKLSLGGTGQVNVGADAATPLADSYHLMEQTDNNAEVVDDDDEDPRPLRVSQDPETPYTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M149</accession>
    <name>A0A2X0M149_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C089g13035 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C089g13035</name>
        <name evidence="3" type="ORF">BQ5605_C089G13035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000032">
        <property type="protein sequence ID" value="SGY28038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1087"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="455"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY28038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1866" mass="204848" checksum="EC587187D1BAE56A" modified="2018-09-12" version="1">MPDPPGAQAPPPDNPLGGNRASDDESLNTLTREPVTGGTANPPAWSTEATQARLDCEKVMQNTFRVLGIVPSGKSTRRLMVLMHDASTPPSQAPLLARAAQRAVRNDAAPASNVIRVIMDGPGSPRGPVQIALRKHFGLAETPFMFARPEGVVLDPEVEKLFSKCVKLNPIVTKATKRFPIARHMYELVFESDQACLEAAAAGPFSHHGKEMVTELPSASPLNHVVQVRFTLPSSSSATPASVLRQSLDDALTLSFGRAGRTQGYTLMQLQRGLAVDPNGDPMAMTEDGFHCAYLRLHADLFQGSTETQKAALNAALPQEIEILGAKYGLRHEFETHYCAVCDRAGHQWGACRKPVSTPATAAPVPGASTSTSTTGFRVAGKNGKHGGPAALNSRASGTNMIQLGPRANPAGAATGNKDDANDDDGDDDDDGGGESVASTEPEGGDTGKETLTRATTGPTKETQTTTAAPVSTPTSPSPSTSAPASPLSGGTSESSATSTTSIASTSPRRLRSSSAPGNRRVTRAGSAMIHGASGGDDSGGNSSGGYRSESLTVLTFNVRSIKNAVNQVKIIRYLKTLRPAPAAILLQEHHLSYNASREGFESAWPGACIRFTPHVLTLIPDGSPLAGHLLSSTPVVFAGAPRLDGRILRSVFRLEELDVEIINMYAPVQEDDRRDFFGLLHFNAPRPKTLRILAGDLNDCPDVSVDRVSITDRAWTPVSHWQTLLSKIAFNALDTVRHVHSCTPAFTRPHYRGRGEERKICSWSRIDYILVQCSWANRLLSASTLFDAPCSDHRPVVATFALPTSNADAEPPLSLPSTSDFISRLNPTVFDDQDFVASIPGVVDEVYRRLEGTAPLGDVYDAALRAVAVAGHARYRSTRADMRRLRAESQSVMEALEARGEHMNEAERDAYAFAKSRLDQLAVKEAQWLRIRAHVPSVDSREGQSASIRTRLNRRSRQTSIVSLEDVDGTETVDMQEALGIASRHAQSLFTPDPARGDPTNARRSLLDPIRAAKCYDDDRSDPTFGRRLPRQARVALDEPFTLLEVEAALKKTDSGRSPGPSGIPYELFKALPTYFAPKLLDLFNSIWEGGKMTASLAEGLVRLLPKNKPGANLKSLGAYRPITLRETTYKVLSKVLVARLNGVLGELLPPAQHGFMPSRRSADAGSHLTLLLEKLKSLGTEVFPEGALLSLDQQSAYDRVDHAWIFDVFEAFGFGERFISLLRALYDPETLGVRYLINGFPTELVRLLCGLGQGDPLSCPVWNITFQPFLDALVRRGIALDLQKVWPGGPRAQLTHLAFADDAVVVVESPAALSKLETLSQTWYEATNGKTNTDKTLVLPLGPNWLRDETAQALPTVQEGESFKWCGYAFFRHGDSKLFWTHVLDRIKAKTRAAGDRTLSPSGKVFYANAHIISTVLHVLSFDIPPQWFIKAAETALTDFVWGGAGRNTVARDFVFQAREDGGLGLISIGDIVHSVALRFWDAVAGSNEAIWAPLARESWRSLVAATRDFSPWGFFSSTARVEKLYRDSTRWGAVVAAARVTVPTIKSELLTLPNCSRFRLASLHSMLKFAQIADLYWRDEGKGWALVGHRRGFWQHSKEPALQHEHVWSRVGQLLKAKALLPKTALRPARIPLKEAPRPRCFNFFGLTRPFTIRKLRRLVNVVRFPGREDRVKRFRDGTPQSDRKRFWRWLHDRFASAAEQDTHWRLMYDVTPTRKKQHVQGHASSPSCLFCGNDAAVIETVSHYFFGCAYSASYWSGVLRILFDKLGIEDTDVDPSTFTQEQLTMGLPLLRGRGRTTSKWMWVRLACAIGFQRLHLLRWHVHQRFEKDRVVAPPSIPSALRAFNRDYLSRAGFVPGARDWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M223</accession>
    <name>A0A2X0M223_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C002g01010</name>
        <name evidence="11" type="ORF">BQ5605_C002G01010</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY29080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M223"/>
    <dbReference type="STRING" id="796604.A0A2X0M223"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072354">
        <property type="term" value="F:histone H3T3 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024604">
        <property type="entry name" value="GSG2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419">
        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419:SF18">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE HASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12330">
        <property type="entry name" value="Haspin_kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01331">
        <property type="entry name" value="DUF3635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine/threonine-protein kinase haspin C-terminal" evidence="10">
        <location>
            <begin position="576"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="128"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY29080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="716" mass="79028" checksum="BC4F7E5BC714123E" modified="2018-09-12" version="1">MPLPGASTRTFKAYGKRKTHTINRTSQSLWDDEEAITNKESVPQTKMPSITLSSSGESNDDDSDTDTDYDQPPKPVDMPLLKSKSNVRYQSQGKRDLATSVALRRAGTAPPATDKENVVPTVITASKNTTARKPSSQALHIVSGPRKPIRPLQVRPTTPLGSPRKKNLSVRPDPSVPAKSSKLAQSSLQFDGVHVPVRRAPKASSSKIAPTPRASTRDLSPRSPIALFSSELDGSVEIYNSFNSLSINKSRTLILEDEDCEEDLTRTDTSSRSPASISRRPEINKTTSTYPSFLKELMSITATPVPYDFTSFVSSPPSPFSISAGTKWTKIGEASYSEVFASEGEEGEQMVIKIIPVSNVEAAAGVLDPNIGNHLPFVSDWTAVQREIWASALFGEGIHGIEGFVEYKGAFIVQGPYPSRLLSEWDLYRRRLQRERRADCDAQIRPSVLHDTQVYAIICLAHAGTDLESFKLKSWKDAASVLWQAAQACARGEEKVEFEHRDLHWGNLLVKPIQKSTPPLLALDFAALSLTGLTPDSVAAPLDSQHTGLQVTLIDFTLSRAKSSDGFVIFDAFDDEEVFDGQGTDCPPPHAQQSGFNPHISSSCAGDPQFDVYRTMRDLIKDDWEGFHPITNLYWLHYLSLKLLHAKKLRRPVSGKSMSIARAAEEIKWYETLVGMEARLKSQVLEQAPKGKKGKSVPRWTSAQDLVRVWKGDVYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M2E9</accession>
    <name>A0A2X0M2E9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00153 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00153</name>
        <name evidence="2" type="ORF">BQ5605_C001G00153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY44409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M2E9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY44409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="575" mass="64869" checksum="3E8797025A15B2E3" modified="2018-09-12" version="1">MLKIGRRRGAGSRSARCGNERYGPVEGVMRLLDFANLTDNIDMHAADGYVKSSTYHERGNTRAHMKEIKERREVPSSYISDANMPEASVAFASPARYPGTGVSKSSNAPPSSLSRPMPVSPIEIDDLITIVLARSRQQPVDPRSKSKLRGAQSRPAKAVFKNGPIMTSQALSDSDDSDDSDDPDDSDEMSSSTPLELQNSTIATLHEDFWLRSEQQCSKRMAIVQALLGLLSVATELKEWLMHMDCLFITNPSMCAKLEMEETIALQAYDYDPKPVLKDASEAYFKLRKRIIRSVIVLIKERRSDYTTPLKRGEYSDPSSWLVSLYTFTVDYIPIPIPRDHLPTSTARVQIETHFQPAGYCSACQCVQIEILPRRHFIVDWPVLLSSLNLSQPTLSEVSAHLLATSNGGPRETKYWASLSQERLHRTLLHPADRSITSLPRVLVFNINNQYPRHEQTPRELRLAVSGQMELVWSLRSEVRYILSGEHFATDAIVGYEEEAARYHFDAMRGHLAYPTGNRTTNGLVTMLFYELTCYLRSMRCWTLDGSFDEGKGVWKMQDASVLFEGFKSVKLENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M2Q6</accession>
    <name>A0A2X0M2Q6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C002g01512 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C002g01512</name>
        <name evidence="5" type="ORF">BQ5605_C002G01512</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY33581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M2Q6"/>
    <dbReference type="STRING" id="796604.A0A2X0M2Q6"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00219">
        <property type="entry name" value="PyrC_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004721">
        <property type="entry name" value="DHOdimr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43137">
        <property type="entry name" value="DIHYDROOROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43137:SF1">
        <property type="entry name" value="DIHYDROOROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001237">
        <property type="entry name" value="DHOdimr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00482">
        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY33581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="399" mass="43949" checksum="29B72120A2BD542F" modified="2018-09-12" version="1">MSASPSTLKLSSPFDAHVHLRQGALMKLVAPHVERGGVRACFVMVSSSPWLLFRFVGSIVPLFPLLQPNLIPPLTEPSQTMDYLTQLQAQAPRTDFLMSLYLTRSLTPSVIREAHSKGIVGVKSYPRGVTTNSEGGVGMEGYSVFDEVFAEMERCDMVLNLHGEVPSDVDGDGTCVLNAEERFLPHLREIHTKFPKLRIVLEHCTTAAAVECVKTLPSNVCATITPHHLALTIDQAVNSSLHFCKPLAKYPSDRSALRSVIASGNPQFFLGSDSAPHPSGAKLPTLKYTRTNLNAVQGEEIVLPSPCAAGIYTQADLIPLIATIFERFEIPLDKLEGYVSEFGRRFYRIPAREGEEVELRRVQEGGRKVEKAFGFEGEKGREFVVPFMAGEELGWELVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M311</accession>
    <name>A0A2X0M311_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C002g01632 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C002g01632</name>
        <name evidence="8" type="ORF">BQ5605_C002G01632</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY34447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M311"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF6">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016127396" evidence="6">
        <location>
            <begin position="24"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="7">
        <location>
            <begin position="102"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="434"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="437"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY34447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="483" mass="49349" checksum="3C8F8FBCB483D544" modified="2018-09-12" version="1">MKLITFELASTLVLLLLPSLTDARPAAAAASIAAVKTAPGIIELPLQRLSKRTRTRDEFLAKANFMRTKYGFDTTSTTESRSKRRRRAAGTVAMTAFQDAEYVGTISIGTPAESHSVILDTGSADLIMAADDCKGCASTTNGYSAAGSSSSASTSTSFSITYGSGDASGTLVKDNVTISGYTIASQTFASCTTMDNIVAGNISGLLGLGWQGLATSGAVPLVQALANSGDLPSKVFGFRFKSYAYDKLTSDYMTGGKMTIGGTDTSAYSGDINWVNIDASKTYWQIPLDTITVRGNDLGISADNVVIDTGTTLIGAPAAAVAAIYAQISGAAAVSLSGSSGYYSIPCSGTYNVAFTFGNVSYAIPADAFNTGQYDSSGNCLGAIFALTSSSSIGTSSSSLQWIIGDAFLTGVYSAYRFSSPAAVGFATLGSGGSAGSGSSSSSSSTDTSSNKSMTSGSTRSASSLTVYPFAFTLGLLSLILST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M3R4</accession>
    <name>A0A2X0M3R4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00570 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00570</name>
        <name evidence="2" type="ORF">BQ5605_C001G00570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY47762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M3R4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY47762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="188" mass="20844" checksum="C22A6BA5BD22612D" modified="2018-09-12" version="1">MCQHTVVSAAPACGVGVPIRSHVQALCAPTHPTTTSSCAKARKGERAGLKSRSNPSSPTFSQGKVQLPPPLRHNPECRQLREGSDSEAIALRENARSYNNALSLTLLAAHFDQTRLGILGPRVFRVLDRLYSSTRRPDPCRQSTLSLCSNVADRPSRHRHSTWTQRRRQSHTKAYFDQARVRVPETAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M523</accession>
    <name>A0A2X0M523_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-(apurinic or apyrimidinic site) endonuclease</fullName>
            <ecNumber evidence="8">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C003g02394</name>
        <name evidence="11" type="ORF">BQ5605_C003G02394</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6 8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6 8">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="8"/>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY40548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M523"/>
    <dbReference type="STRING" id="796604.A0A2X0M523"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09087">
        <property type="entry name" value="Ape1-like_AP-endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF6">
        <property type="entry name" value="DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 6 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="10">
        <location>
            <begin position="120"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="7">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA substrate" evidence="7">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY40548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="402" mass="44780" checksum="1A93B2EBC82038B5" modified="2018-09-12" version="1">MAPRKRKSLPVPVNASPTRPEPPLVPEHSPLSALGEATVDSPSSSAEEQGAAPSKKKSKKTVKEPKPPKEPKAPKEPKAPKPKPGPVQPLDPTLPTNKTLPDPIPPYPQRPEGQVRISAWNVCGIKAAENKGMERYIRAEAADILVLTETKMADPNFAFLNDNYPAIDPSKKGYSGTAILSKIEPKSITFGLPTSSDQAAEAGRCITLEFNSHFLIGTYVPNAGQDLKSLPRKSQWNHDFSLYLHQLDAIKPIIWCGDLNVVPAPEDIRNWKTNHNKSAGCTDEEIHAFERQLRGEEGGKGERLVDVWREKHPDKVGWYTYFSMRFDCRTKGIGWRLDHFVVHFFFLFSIRLQSSGTEEASLSHNMQVSERILDKVKACEIRLEAYGPSDHVPIILDFEGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-11-27" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M5Q9</accession>
    <name>A0A2X0M5Q9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C003g02453 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C003g02453</name>
        <name evidence="3" type="ORF">BQ5605_C003G02453</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY40973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M5Q9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="2">
        <location>
            <begin position="483"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY40973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="576" mass="63535" checksum="6FC5D45D083F7E5C" modified="2018-09-12" version="1">MARSVFGFVFSSPWTKDRLAPKFNLVASDQFNRELKLWCTIIENTTGQQTGKAQPTMSRKAESLESIGLLTRINWPAWAPAMRLALQSISAFRVATGEQKKPPALQPPNQSLKDYTSLCNDYDAKDAKGRTLIRSHVDEDTWFKLKGSAVDASLHQVWTGLVRAYETNSVPFVGTKTLRAYWNLRYEPGTSVTSFMTEVERLGELCNRQKMSFWKQQLGIGTEELQGFYAQIVDILGEERGKALLSMVLHVDDFAIKTVLMEQLPEKYTFAFREEKDVDLFLEKVRTAYDEDVIMNGANDKEQTEAPASALAAARQEADPGQAPPCNGNCACGQQPHAFATAGQHRGHAGPTRNSYRSGGHGRTGTRMGAKTRAEHYANSDKWGKIVDGKFMCANNQCVNCFGFGHRRAACDSRNPTGDRIAFLQSLDINVPVASHGTYFVEDPVPMSLANPMGASFHFTNYAAEVREQTIFRAATAEAPELIFDTGATTSLVNDKCMLSDYATLDCPIFMIDAAGTRTPALGRGTLTAEFALADGTTSKMTIADVLHVPNFVVNLISGPSLCKQGVRIEMEDREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M5U5</accession>
    <name>A0A2X0M5U5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C003g02392 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C003g02392</name>
        <name evidence="9" type="ORF">BQ5605_C003G02392</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-histidine(out) + L-arginine(in) = L-histidine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71063"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the laat-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY40530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M5U5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034488">
        <property type="term" value="P:basic amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000009">
        <property type="entry name" value="PQ loop repeat family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF34">
        <property type="entry name" value="LYSOSOMAL AMINO ACID TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="566"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="607"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="117"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="339"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="639"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="765"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="219"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="382"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="395"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="678"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="771"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY40530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="832" mass="91943" checksum="18770E68537AAE74" modified="2018-09-12" version="1">MWPLLPGMTWEGQEQLSTWFGYASILAWLCAQAPQVLENHRNKSVEAIALPFLVSWFFGDFTNLIGCILTHQLPFQTYLATYFVMIDAMLMAQFFHYSRANPSTSIPPLSIDYPYAQTPHTHHHHHSHPHHHHRESQSSVRRSKSFYRSSSQQHSATPSRRRVKALTSEDGPEFGETEGEDPMMTSWMFQSSNATTPARSLKNGRTSTSTSEVMVPRASRTSTTHSIVTNPTTPQTLSVSTSQVLSAPSTITPPSGPSSPPFETPTTMTSSLGSIASTSEARGRTMTRNLNPHHHYLHHYHHPSNLETISGSPASGSPAPLMRSLMELEQQARDRALEMGHDGGRGECDEEDDETERGRSIHRVNDLPSNVLPQYVRETTPRHHHSSSHHHHHQQSGSGRSSSRSRPPPPARRTSSMLFLSVGLFFTFTTLGRRAEKGLGSFAGGSTRAWEMGLPKLNWVQESTVRLSKREMVTSSPLTASIGEKRDNDVVMSDAVYLVDPKVASGRDWERFIGRMSAWTCTTLYLTSRLPQIWQNVSSPSLVPNIPVGLNSQRPLSLSQFRRRSVAGLSMILFIMAFVGNSLYVISILLNPLATESVGYLLESTPYLLGSGGTLCFDITIVFQSWLYSEKRKRNRAMMRMGLSRGDSTGARGRGEEEGLLGTTTDEEEGVEGGRTRSSSRRIGRKRSTSSKRGWGGTSRSLDRHDPAFKMSRSVSSHRTSRAPSVRTFTTDGGAEGAHTTILAESGGPRLSRAERVVLDDLEYEFDHTRSNTSSRGPSPNQLRKEPSQAGSGLPSRSGSTSRTRSRTTSDDRTSSLGVVPETGESNLTLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M6C2</accession>
    <name>A0A2X0M6C2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C001g00289 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C001g00289</name>
        <name evidence="1" type="ORF">BQ5605_C001G00289</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY45480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M6C2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY45480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="595" mass="66522" checksum="3B3B5185B3EEC86A" modified="2018-09-12" version="1">MQLLSRFFRKRSADNTDDRMKQLAKLSRARLQQAKVIPSSDDTAVRILIDFWYFFDRIYVSKKHGAAKAFARAFSDAVFIPNADDRLLIKARLAKLGMTWEEAVRSPSKQPLFNKAAHEAAKRCLEAIRKGQGQLYTDLGPCGGPDGKADDGVRLYSCQRDTNSLEGGIHRNLRQRFPKSGVSPCHVNACTADYVPVHNLTVSPTPPSQFEEAATILTHSPLYSQVGTFNRTGKPFVGHYDLWLTVELHRLRRKTPAFFPRHSATVSDIVNPLLYTPSTETFGIVLVVQSPTAQMRFLIEPYQVERGTLRLEPVKWSPWNLLQNNTPAIQHMQSRLAIDRKLRPDWPAERQGTRFAVLYVHTPSERALYRYLSSKVRLGAPQNLRIFEITEPWNKYANGLDIFYKMPEHINTWAPRWSSLANAQATMNMGGNDVIVIQALLTDLSRGRDVSMLAANPLLGHKLPVLGRLTEVEVDFSDPSTSSIRAFVATASSAGSSADLGTSSALTRAGTTKGARHCRLCGQTTCRRKGTKLSDDGSVNECDGACLDCGKPFGLTDEMDPNDPQSRRFCRGLTRAEMNGRAWQQKKCHNYVAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M6S9</accession>
    <name>A0A2X0M6S9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">S-adenosylmethionine synthase</fullName>
            <ecNumber evidence="10">2.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">BQ5605_C001g00147</name>
        <name evidence="15" type="ORF">BQ5605_C001G00147</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the formation of S-adenosylmethionine from methionine and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-methionine + ATP + H2O = S-adenosyl-L-methionine + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="10">Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the AdoMet synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="10"/>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY44360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M6S9"/>
    <dbReference type="STRING" id="796604.A0A2X0M6S9"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18079">
        <property type="entry name" value="S-AdoMet_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000003">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000004">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="S-adenosylmethionine synthetase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 10" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-adenosylmethionine synthetase N-terminal" evidence="12">
        <location>
            <begin position="4"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase central" evidence="13">
        <location>
            <begin position="130"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase C-terminal" evidence="14">
        <location>
            <begin position="253"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SGY44360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="400" mass="43880" checksum="E3B6F71495466248" modified="2018-09-12" version="1">MSSKFLFTSESVGEGHPDKICDQISDAILDACLKDDPWSKVACETAAKTGLVSDFDTTTSQTPARIMVFGEITTKSPLDYQKIIRDTIKRIGYDDSEKGFDYKTCNVLVAIEQQSPDIAQGLDHGNLENHGAGDQGIMFGYATNETEEMMPLTLMLSHKLNKKMADLRRSGELGWLRPDSKTQVTIEYEKLPNGAVKPLRVDTVVISTQHAEEISTEDLRKELIEKVVKTVIDPKLLTDKTVYHIQPSGRFVIGGPQGDAGLTGRKIIVDSYGGWGAHGGGAFSGKDWSKVDRSSAYSARWIAKSLIAAGLAERALVQLSYAIGVAEPLSIFVDSYGTVKEGYTDADLTKIILKNWDLRPGVIVKELGLQAPIYAQTACYGHFGNPAYPWEKPKKLDLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M7D2</accession>
    <name>A0A2X0M7D2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C001g00387 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C001g00387</name>
        <name evidence="3" type="ORF">BQ5605_C001G00387</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY46133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M7D2"/>
    <dbReference type="STRING" id="796604.A0A2X0M7D2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.120">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036533">
        <property type="entry name" value="BAG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003103">
        <property type="entry name" value="BAG_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02179">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51035">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAG" evidence="2">
        <location>
            <begin position="186"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY46133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="287" mass="32712" checksum="2723B605F2BFF119" modified="2018-09-12" version="1">MLQSMLRDRLGSTQAQRQRELYHEQRRRAFAMEAQRRERQRLAYEQQLREQEWARRMSYSPSWDPRQRDHYVHHDDDGDEREDEYDSAEESDFVIQAACLSDQVWHLNPHHRACNVWSNQRRRRHDLAETLPSSTLPSPGLGCAGGPCRHFAQRSKVEIATKLHACNGKLAYDSHNAAFHAYEDALVKLLTQLDEISTKGDDKIKAASKALVRKIEKELNRLDQIKEASLAQVALSTPSSEAEDLGNQDAGSEGEQIAGAEEEEEWHGIPSDTESEAESTGDIEPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M7H5</accession>
    <name>A0A2X0M7H5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GrpE protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C007g04637</name>
        <name evidence="7" type="ORF">BQ5605_C007G04637</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the GrpE family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY61999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M7H5"/>
    <dbReference type="STRING" id="796604.A0A2X0M7H5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.22.10:FF:000002">
        <property type="entry name" value="GrpE protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="GRPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237:SF23">
        <property type="entry name" value="GRPE PROTEIN HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="Coiled-coil domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="36"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY61999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="259" mass="27853" checksum="89919B81A795C6E7" modified="2018-09-12" version="1">MFQSAGRTLLRSAPSSASSSMNVAARPAFRSVVLGATIPTPTPTPTPASSFPSPYLRSFFTTRPSRSETPKAETSEAEEGAASATATAAPTDKTAELTQQLEEKNKIIAELKDARLRTLADYENLQKISTREKAQAKDFALQSFAKDLISSIDILVLALRSLPPTKLDPSQGASKDLIDLHQGVSLTKDSILKTLERNGVKAFDPTGEIFDPNRHEALYQAPVPGKEPGTVLECQEIGYMIKDRLLRPAKVGVVAGKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M7K0</accession>
    <name>A0A2X0M7K0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C007g04667 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C007g04667</name>
        <name evidence="2" type="ORF">BQ5605_C007G04667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY62222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M7K0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="677"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="695"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY62222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="704" mass="76081" checksum="0DC80B7F8281A15E" modified="2018-09-12" version="1">MALLPAPPPPTFPTRFQATDDDLGHVVAASTGADPAVVPVAWPAEITASVSGEVLTGSHRSRDREAVIAWKLKTEREQYLEALETKLTKLAQPAKLGTSKTDSGYGGSHTSPQVGLDRLLLMHDDLLDDIDINQPVLATMPEQPEGFTDEDDEDEDDEETIQGRSLLSRAAKPGVTDGLRRSEPSPGQKIPREEETPSASPRKDDNIFVIPPTPSHEDVEEARQREHSAEAVTDDPEEENGDGQDDEEMPPLELNRRPSTLDNDPNSAHYPSEDSSEQPRRISFSSSVRISGGIRSKGRSSRTRQRPAIPNDLFSPAPSTSSALTVEDVARMGYMAHPLPRNASLNQSRGSSRTNSPSRGATTAGISILRTVSSSSSLGIHNSYREAAILNGGASSIYSSSVPSRSSSPCSSIYAPLKRPSETCPNPMSVKPPAKRVRSAPRTSVSGLSFREFLRLNGLSRSGDADGAGAEDEESMAERGYRELVEEQRRRKERLDKRKKQHTGRASSVLNGDLGQDPTASRGFWNRVWGMLGNGSGRSGIGRTSSGALLGATPTFPVYGMTGTTPLTTDGSRRVERNRSSLSISSSVAGDQGSSDEGEADDPRTNVNALSSRTRPISNASGDTKERIKSEVDVRFGPAPGRWFSSGWILWKLRAMGGACLGVRKKIRSKRRALVSSSAIDTSDEESDSAMARNNDLRRAYQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M7M0</accession>
    <name>A0A2X0M7M0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00789 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00789</name>
        <name evidence="2" type="ORF">BQ5605_C001G00789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY49543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M7M0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY49543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="83" mass="9581" checksum="8DE5DC1379AADF01" modified="2018-09-12" version="1">MCIARLVVIQNFCVLTAPPVSLPHPRILTCVNMCKDTPARARDMRKDTPARARDMRKDTPARARDMRKDTLARKEHWLLLVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M7M4</accession>
    <name>A0A2X0M7M4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C007g04697 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C007g04697</name>
        <name evidence="2" type="ORF">BQ5605_C007G04697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY62477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M7M4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY62477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="135" mass="14698" checksum="1253B112B9ADB0FD" modified="2018-09-12" version="1">MTHREDDRRVVEDLRTEGEDLEPDAWSSECAGLIDDVDDDRERWALGDALRGDECPMRLLKRAGVGEAGGWTVVAPVLRPDPNVGEIRGAEVAEVARCLRVELEIAHVGGCRRSGTSESSSVKTNMLLSKVGGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M822</accession>
    <name>A0A2X0M822_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C001g00648 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00655 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C001g00648</name>
        <name evidence="2" type="synonym">BQ5605_C001g00655</name>
        <name evidence="1" type="ORF">BQ5605_C001G00648</name>
        <name evidence="2" type="ORF">BQ5605_C001G00655</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY48395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY48490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M822"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY48395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY48490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="42" mass="4849" checksum="748F11147AAB3B3A" modified="2018-09-12" version="1">MAVRREVRTKSYRCVATGVEFQVAVRQSITRARRWKGVANNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M8A5</accession>
    <name>A0A2X0M8A5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C006g03845 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C006g03845</name>
        <name evidence="5" type="ORF">BQ5605_C006G03845</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY54146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M8A5"/>
    <dbReference type="STRING" id="796604.A0A2X0M8A5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11398">
        <property type="entry name" value="bHLHzip_scCBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047206">
        <property type="entry name" value="bHLHzip_scCBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47787">
        <property type="entry name" value="CENTROMERE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47787:SF1">
        <property type="entry name" value="CENTROMERE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="4">
        <location>
            <begin position="224"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="317"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="91"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="176"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY54146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="347" mass="36496" checksum="6969A4FB0D1275BD" modified="2018-09-12" version="1">MAQQQPLPKKRGSNAAGARSSERTAAAPSSKKGGKKNADETPAAADKNVDSSATAKGKADGNKTNGTGPSTRNLSASIASQPHQQAPQPPTCNGRTGSAAQASTTIDPSATGGTTNASANPAERNDSRASSENGSDADYSEDNDESYMANATAPATTNGKSKGKKNQARAAKKEASTTGASTGNANASTSAAGAAANGNGAAATNGDDEEGGEKLHTEQEWNRTRKDNHKEVERRRRETINEGINELKNIVPGCEKNKGSILSRTVQYIQQLKDREATLKDKEATLIEKWTLEKLLSDQTTSDLKREVEKLREELSIARMQNGKRGEVDGGGQYGGSEPKRSRLEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M9D6</accession>
    <name>A0A2X0M9D6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C004g02953 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C004g02953</name>
        <name evidence="3" type="ORF">BQ5605_C004G02953</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY69081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M9D6"/>
    <dbReference type="STRING" id="796604.A0A2X0M9D6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.550">
        <property type="entry name" value="ASAP complex, SAP18 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010516">
        <property type="entry name" value="SAP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042534">
        <property type="entry name" value="SAP18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082:SF0">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06487">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="201"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="318"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="369"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY69081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="384" mass="41594" checksum="C1380B1A8DC35232" modified="2018-09-12" version="1">MNQRPRSGGPSGYASSSSRGRGGYHPSGPSSYPNRPPSAPSRGPPPPRQRSPSPPPKVKRSTTVPSLLRVFVSRTPQHHDEALFSSPDGTGPARSILQDEYQLYVWRDSTLKELVHALASSFTLPTTPPNIRYSFKLVYYDAQSSRHRSKPIGLLTNRDIFHSTKSTTGTAPGDKTIHQTSWVVGDYLSIALQPTFNAGGAPSFGANKPQNAYPNRGPPSSSGFQVRGAPTRGPAGDRFNAGAPAAPSFGIRGTATSRASANDDRWASNSNDSRLPPSSVPSAFGFGDSNRAMAQERWKTNSEMSASAREGTQDAHSAPRRRLSISSKRSRSRSPGPRSPPRKEGKGGDTWEKGTEWDTKKASSPQSTSRREENSPMRDVRRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MAE5</accession>
    <name>A0A2X0MAE5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g04203 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g04203</name>
        <name evidence="1" type="ORF">BQ5605_C006G04203</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY56969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MAE5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY56969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="71" mass="7914" checksum="0BB0A9A5E9081BEB" modified="2018-09-12" version="1">MGITFLDLTGIVAVGFFMEDLVGGKGNRTLKLPLPVVSRVSRYLQRNIKHSSEVCFDCIDSSKYEGTLKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MAF0</accession>
    <name>A0A2X0MAF0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C006g04204 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C006g04204</name>
        <name evidence="3" type="ORF">BQ5605_C006G04204</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY56976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MAF0"/>
    <dbReference type="STRING" id="796604.A0A2X0MAF0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY56976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="251" mass="26697" checksum="E431C65E3482D068" modified="2018-09-12" version="1">MKVDSMKKRRTLKESDYDERGSLGDRSQPSNPRRSSSHKLGSTTTKDDPQAPSKTDGPGSASSGLDSGSGSPSQAVPTAYVNVNSSVPLANGTTIVQEPVTIVVVVNNTPTLPTTLSPNPTSSDPTTFTSSNSPLVAPNSLSSSSSKHLSHCDIAGIVVGSLVGLGLLVLLVLWAWKKCTGSRRGGVYEDSELCTRRCPSSNRRRKKLTLPPLFIKNPLHPDTELAPKQELKGLLLPSGIQSDQARLIRDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MB09</accession>
    <name>A0A2X0MB09_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C007g04394 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C007g04394</name>
        <name evidence="1" type="ORF">BQ5605_C007G04394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY60214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MB09"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY60214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="470" mass="52663" checksum="7082E077905833E5" modified="2018-09-12" version="1">MYLDDPDIELLDDNLERMAPFLNVRVSRASRLPLRQPIADTQIQLSWSTDEPLEFDTLPRPLAAWTDKFKDRGAITAARKQGYRSIAIAGHRLPFGVERIWRHIDYAERMRSIVISSQNAFLHTRLDFVVEHAVRSLAALGLNNDTAPLAVQQAYDEADAQAEERFLLDVIVTANESLPGRAQILRLPSLLRHDTRQLALDPKSLIEHRRAHQCAHLKAVLLKGRHGAPTSTAQDFDPTSKAKLSKHGEMYSSVLRGLVHSMGAARLEAVSGVARSIRWTGQTAFSRFSTANETENIGYIEDRRKDVSCNCALHIWPRECSSIISILAQIRMQLRARQYTAFANARSIRWTGQGTFSRFSTANETENIEYIEDRRKDVSCNCALHIWPRECSSIISILAQIRMQLRARQYTAFAKIPPFGSIDGNVTSATPLKIGSLVCFVLKRGIIPASCASNIGEEQLSIGLGSYTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MD32</accession>
    <name>A0A2X0MD32_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="22">BQ5605_C013g07404 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">BQ5605_C013g07404</name>
        <name evidence="22" type="ORF">BQ5605_C013G07404</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0229">DNA integration</keyword>
    <keyword evidence="15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="12" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="16" id="KW-0862">Zinc</keyword>
    <keyword evidence="16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="20">
        <location>
            <begin position="422"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="21">
        <location>
            <begin position="1579"/>
            <end position="1751"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="19">
        <location>
            <begin position="1894"/>
            <end position="1955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="483"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1291"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="42"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="484"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="512"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="SGY15560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1957" mass="217397" checksum="FDFF06B55155F0B6" modified="2018-09-12" version="1">MAEPTDTSRDTTAPVREDPSRANPPKSPPTHSPHPLQAAAVITSLESRLAESEALRRDSETRIRKLEQMVERLMRESTAPAGAQVGEALPVRPVPLDVPPHTFLGRPGAAADPLARTPGGESHSGIRDGPSSAVISSRWRGTLPDREGLWTGDHPERLVIFTAFGESYLSLLCDISTSDLFDTSRVIQLVATLFSRTTTRQRRQSPLDWAVEAMRDALGEGRPHCWTSLMKAVGRRWPDPGFADRVAQDFHGCRQSSSRAYDHVGEWRARYRAFVHDNDSFTLSPLQLATTFYQSLSDSSKREVRAGMLREYHDNSLVTIGRFGLKVPSIDEITEWAAIADDISPPPSVPTPPSRTATYGAIVKAPRVSPPATNTPTVDERFQIRRARWVDRATKWQQSHLWKDRSTWFSPAPSGVPTSMACFNCGRGGHFSQHCTAERQSPVAVQLSAVAVADLDDEDWSSVAGGDEDPEVRVPISLERVQTRPLSSVSASMTRPSCPPADPVGRMKEGASSSVDVEVSSSNPQPTAPASDADLRRLADDSTDSAFDAVEDVPSYADAASRMRRYWGPEVVSSRKAERTASVSSVRVPVPLGVSLLESDTPLIDVDDFARPAEPAIVRARNIIAWTLPSGRTLRCLVDSGSEVDLVDQDVVRTDPSFTTSRLTAPLHLRLGTRDKSDRCAVFANALFTSGSLDLGLRAFFICRVTAYDAILGLPFLKDTGMLVGWGVFTVARPGPSQPVAKGTHEWDRAVTVAPICSGSAIGYDHPGLLPDDEIIGLEPHNPLLDVVDDPALEDLSESEARTRLAALLEKYSDVFVDSLPMDRLPPYRPVNHEIPLIDPNEKVKPRVYPLADKYRSQWAEHSAKYTRGRFWVSGPIDSAAPVFAIPKKNSQTARFVIDLRARNSNTAKRFSPIPDMTSVRYEVARSRYRSKFDVAAAFEQVRVIPEHVDRTGFATVTGTYTSRVMQFGDTNAPNTLNLLTSAMFQPCLSFAKIFFDDVHVHSDTRRAHLRHIEILLMTLRHYRFYLGSNKSEWFSKSLDSLGAIISDDGIEVDPAKWERIRQWPTPHNKTDVQRFLGTVNWMRDHLPHLSITLEPITALLAQSTSWRWNEHEQQAFDTVKSLVPATLRPIDGAKVTSGEHKIYLFTDASRVGIGACLASGPTRSQAVPTRFFSAKFNGAQLNYHVTDKEFLAVVSACRAFEQHLIGYPFVIVTDHQALRTIKTQKLRQTPRHIRMCLELSRFDFEFEFIAGKNNSLADSLSRLWEVKEESPEDQVKENELEDMFFDGERHGFTTHGESLPEERPYTSPSPDRLPPVDFAFGPQRDDCEAGSPGYSALKDESQDEDVNGRDLGNLFLKEECHEFTTPGSPGSHRLAENIMDTVDSSTGPLSPPIAVNRVQAIAAAPANDAPIPVDADADELDLLGAAADEVNDAPVVHRPPDPLPQPFLDAVIRAYAHDSQAQVIVDDPLSWPMFRVTEEGRILRVHPDESLSLFVPRGLATGVVDSDKVPSLRELVLSEIHRSVGHAGHRITLAAIRPLYWWSSMSADCAKFCHSCEDCARGKASTQVPYGRLHPMPIPSGPWEQVAIDFMTGLPPVEFEGMMVAQIMVVTDTWGKMVHLIPLPADADSELVADRYYATIFRLHGTPSAIVSDRDPKFTSQFWRALQAKVGTVLRMSTAAHPETDGSSENRIKMVTQTLRIMVSSNHEAWASRLVEAEFALNSSVAVSTSLSAFEATYGYLPRRWPTDSWSVSDVPRAEAFARIRQLRNLDVTDAIIGARLDQTHQANKHRRPDDPAFRTGSYVYLSTKNLAVPEGMKSKLLPRYIGPFRIRAAIPATSSYDLELPPAMSRVHSRFHARLLRPYVENDAERFPGRDPAVLFVEDVADAADNSAIPERIVRDRRNARGNRSFLVRWIGRKDIDDTWMSEQSLRFDHPSLLDTYLAQLDRSNRRLSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MDF6</accession>
    <name>A0A2X0MDF6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C004g02838 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C004g02838</name>
        <name evidence="3" type="ORF">BQ5605_C004G02838</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY68012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MDF6"/>
    <dbReference type="STRING" id="796604.A0A2X0MDF6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF33">
        <property type="entry name" value="KYNURENINE FORMAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="46"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY68012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="294" mass="32441" checksum="21089B76E59201F7" modified="2018-09-12" version="1">MVGYTTYKDLPYTSTSCKRQAFDLYLPSASTTKPSSSSGSPPPLCVFIHGGAWRTESKEQWAESLMPHIVRSLGIPAACLDYRLAPNDPHPAQILDVISGLTRLTSTTPLPGIETSEHLLWDRQRLILLGHSAGAFMIAEVLLSPPSSMPSDSSSESFVVDPSLRRAIKGAIFLDGIYDIPDLIREYPDYVDFVEMAFGKDPQVWAKESPAKWEIPSEQLGALRAKLLVLHSAQDELLNLVQPRLFVQALEKLGIEQGKQLEVDYETITGGHDEALKNNDSALLGTVKKWIARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MDW3</accession>
    <name>A0A2X0MDW3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Galactose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="4 15">2.7.7.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">BQ5605_C009g05777</name>
        <name evidence="18" type="ORF">BQ5605_C009G05777</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="4 15"/>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY85786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MDW3"/>
    <dbReference type="STRING" id="796604.A0A2X0MDW3"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00608">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000002">
        <property type="entry name" value="Galactose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019779">
        <property type="entry name" value="GalP_UDPtransf1_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943:SF1">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00117">
        <property type="entry name" value="GAL_P_UDP_TRANSF_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10 15" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="8 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase N-terminal" evidence="16">
        <location>
            <begin position="14"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase C-terminal" evidence="17">
        <location>
            <begin position="229"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="12">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="37"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13">
        <location>
            <begin position="86"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13">
        <location>
            <begin position="178"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="355"/>
            <end position="356"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="360"/>
            <end position="361"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="SGY85786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="391" mass="44130" checksum="D912E64084F878D3" modified="2018-09-12" version="1">MSTTTSDPEAVSFDRSSHSHRRFNPLTRTWVLCSPHRTKRPWQGAVEPPQLDSRPAYDPKCYLCPGNERAGRVRTEKYEGTFIFENDFAALVEDSVLPPPPIPEADESVKSLFRQESARGKCHVICFSPRHDLTVAEMKDQEIEGVIEAWTKLYKHVSKEYPWIKYIQIFENKGSMMGCSNPHPHGQSWSLSYIPTIPSQILESQLAFASSPTPSNSLAPLSQNGTPNLLLTYVTQELAFYAENPEESRVIFKGDDFVALVPFWAGWPFEAMILPYKRQIASLSHLTPSEISDLATSIGHLTRRFDNLFSTSFAYSMGVYQTPTDNSTNSSAYLSTTQLHLLFLPPLLRSASVRKFLVGFELMAETQRDITPEQAAARLRGVEGETHYKLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0ME74</accession>
    <name>A0A2X0ME74_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glycerol kinase</fullName>
            <ecNumber evidence="3">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C039g11761</name>
        <name evidence="13" type="ORF">BQ5605_C039G11761</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="3"/>
    <dbReference type="EMBL" id="FQNC01000060">
        <property type="protein sequence ID" value="SGY89646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0ME74"/>
    <dbReference type="STRING" id="796604.A0A2X0ME74"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07792">
        <property type="entry name" value="ASKHA_NBD_FGGY_GK1-3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000086">
        <property type="entry name" value="Glycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042018">
        <property type="entry name" value="GK1-3_metazoan-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF69">
        <property type="entry name" value="GLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="12">
        <location>
            <begin position="735"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="492"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGY89646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="989" mass="107487" checksum="2C867E6ABA984986" modified="2018-09-12" version="1">MSSVFALTMTPTSSPPTSRVTSRRGSAVSINRPPLANRGSTSIPGSRASSPQRPVNPESEFIGSIDCGTSSCRFYIFDQYANVICWHQKEFEQLYTEPGWHEHDPLTYTKCIDACIVQTLKEFQGLGYKQSMIKGVGIAVQRETTVVWDRTTGKPLHNAIAWPDARNAATVRALKERAASVTFNTPDGDMKGEDAVRVITGLPFSTYFSATKYAWLLENCKEVQEAKENGNLMIGTVDAWLLWNYTGGVKTGKHITDLTNASRTLLLSLHTQQWDDQLLEFFDLPRSALPTLASNAEKYGQFFKGHILEGIPIAGLVGDQQAALVGNKCLERGSAKQTYGTGCFMLYNTGRDIVGYKAGPNAQIAYALEGSVAVGGSSVQWYVTQEPAWYSLVRAKVASRLADCGASSFSRLRDNLGLIKDAKEAGELAEEVEDTGGVYFVTGFSGLFAPYWDMAATGMLIGLSTYTTKHHICRATLEATCFQTRAILEAMTKDTQGHASPEGSVSNGRDDGDSDDEADFKPKAVGAGGMKALKVDGGMTSSDVTMQLQADILGIRVERPTMRESTALGAALLAGSALNLFGWDLEDPSTLRKVNEFGMDIFMPSIDAQEREWKFAGWNRAVNRAMAWKNHPPTMANAALRTSMRRASATIRTSCSTPTRVPTYRSFWSSASSTATGAASAAASSSTSSLPFLFPLTSTFSEIPSIAPDVFPLLLAVLLTTLDEDDPSSSSSLTPPWTVLPTSSGSGYGAFASSSLTLGQLLIAERPLCIWPQGLSEQEAQKLFDRLTDDKKKVYLSLAGEVSKEGDGDGPRDRVRAVRTTNGFGIELPESGGIVVGMVFPKIASCRPNAAQAMNFRTLRMEVYPLTSISPSSEITIEYLPLITQSRAQRQKTLQSSFGFSSCLCPLCTSSPQETEASDLRRAELSRLAKEVKQGGRTGDRKGTIKRLERMSVVLLEEGYEGMPEFEDEVVSNAYAAYRTMSIRQGKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MF43</accession>
    <name>A0A2X0MF43_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BQ5605_C008g04962 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C008g04962</name>
        <name evidence="12" type="ORF">BQ5605_C008G04962</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY78818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MF43"/>
    <dbReference type="STRING" id="796604.A0A2X0MF43"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000039">
        <property type="entry name" value="Protein translocation complex component (Npl1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075">
        <property type="entry name" value="SEC63 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075:SF0">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="11">
        <location>
            <begin position="101"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="599"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="599"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="637"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY78818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="665" mass="73757" checksum="A8B1F6E122724B87" modified="2018-09-12" version="1">MAGQYTYDEVGNSYFFLLTVMLLLLIPLTWITIRGGAEAAAKRVPYPCEGWNKKSVELQRSSASINALISIKHVMLAAGWVAFAVVVQKATTVKAESVAFDPFKILGVAMGSSEKVIKKHYRKMSLKYHPDKVGLLVNQTKEEVDNIFVELTKAYKALTDQVSRHNWEMFGHPDGKQEFSQGIALPSWVVDSKSRWYVMAAYALVLGGLLPYSVGQWWYGTRKLTKDNVLNSTAVTFFRALKEETSFPVLVDILAAADEFAVDPELVSGRKKLGKADIDEYARLTSTIREGVDGKSGWEGYGMWSTAQKRARVFIAAHLLRVPIKSPALIKEKHRIVTLALPLCNGLSSIVLAHNWLSTYIAVQHLQQFLLQAVHPSSSPLLQLPNLTPEIAQEANKVGAHTITDFGRLNAGQVEKLLPGIPEQHKKEVFEVAKHWPVVSFVDAKFKVVGETIVTPGAIISFTVKLRITPPGQFMPEITSVTVGKQEEEGEEESIDELIGRRKAGEDGDEPTPLAHAPHYPKNRKPTWSVFIGDHKLNRIFVAPHKFTDMGPHRVRTIRVSFQAPPGPGLYTFQVYAMSDSFVGTDAQKDMKMKVDEAADDEDVLGEEDDISEPDEDTIAGQMALMKGQSVKRAARDDDEDDEDEDTSGTDDDEDDDDTSDSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MF90</accession>
    <name>A0A2X0MF90_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BQ5605_C037g11626 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C037g11626</name>
        <name evidence="12" type="ORF">BQ5605_C037G11626</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKN1/KRE6 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000062">
        <property type="protein sequence ID" value="SGY94081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MF90"/>
    <dbReference type="STRING" id="796604.A0A2X0MF90"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000135">
        <property type="entry name" value="Related to KRE6-glucan synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF15">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="11">
        <location>
            <begin position="325"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY94081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="736" mass="79644" checksum="ECCE60C698924D3A" modified="2018-09-12" version="1">MPSFNPLPLDSPPASPSLDQMSSFQTQPNLRRPQHSPLNPSSNGHGGGGDGRTERQGSAGSGSASSSAESAHHPMHNSGNLARMSRSSTAPINSMGVRRGDSSTLDHASLGVLSGTIGGSFGPFPRSSTFSTYADGKAPFSRRDSMASSDVAIDLVGGEQAYVPTSGYHYSQSDNSLAQRAGAQTPPWHDNSPLIDGPVAQNGAFARHNGDLLWTKENAADDDYLHEPDPAVEAMMDKQWGAPSWRGLFNVGVLTIVIVVIVGLFAGWPIYQYVLTGRFPNSASGTGMAWGWGPGGINGSGQVPKITGLPSLIDKDTPHSVYTRKGHDGNTYNLVFSDEFNVPGRTFWEGDDPWWEAVDLWYWGTVDYEWYDPDAIVTKNGKLEITLTREPIHGLNFRSGMLQSWNKFCFSGGGIIEVSMSMPGTSKAMGFWPGVWTMGNLGRPGYGASNHGMWPYTYNSCDVGTLPNQTWPNGTSPVAAKTSGSKDYGGELSYLPGQRASACTCPGEDHPGPNVGVGRGAPEIDINEMQVDYRGTGSTSQSIQFAPMDAGYLWKNTTPETVIYNASKTFQNQWQGAVYQESASVITLTDDTSYNDAGYTRFSYEYTTGPDGFITWAVNDTATWTINAAAIGPNAEAGIGQRLISEEPMSIMLNLAISDKFQPPEWNKIVFPGVLRIDFVRVWQQGKGDVGCDPSHHPTADYINRHPDIYTNANLTLYTHTNYTWPKNRLSATGCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MFX8</accession>
    <name>A0A2X0MFX8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C008g04970 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C008g04970</name>
        <name evidence="2" type="ORF">BQ5605_C008G04970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY78841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MFX8"/>
    <dbReference type="STRING" id="796604.A0A2X0MFX8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY78841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="215" mass="23169" checksum="D6452B14444EBE95" modified="2018-09-12" version="1">MASTQVTDATSACSPSTTSPERERLEARTMPAPPPFLFDLPTQGSDVLNRLHAFLPQIRDANMRLEQQQKDGTSLSARDGDERAGLVDGDEDHEEQEEVVVLEEIESSDSSDSDDGDSDDNDSGDDDDDDDDDEDDDEDDSEGHPEVGQNSKRGVEQAGDEDPAMAQPRRSAASGLSHLLDIQGNSSSADSPDRPTKALPSSKGKITLIQEIDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MG85</accession>
    <name>A0A2X0MG85_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C017g08369 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C017g08369</name>
        <name evidence="6" type="ORF">BQ5605_C017G08369</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY19888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MG85"/>
    <dbReference type="STRING" id="796604.A0A2X0MG85"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019150">
        <property type="term" value="F:D-ribulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019321">
        <property type="term" value="P:pentose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07782">
        <property type="entry name" value="ASKHA_NBD_FGGY_D-RBK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006003">
        <property type="entry name" value="FGGY_RbtK-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01315">
        <property type="entry name" value="5C_CHO_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43435:SF4">
        <property type="entry name" value="FGGY CARBOHYDRATE KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43435">
        <property type="entry name" value="RIBULOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="4">
        <location>
            <begin position="3"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="5">
        <location>
            <begin position="307"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY19888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="609" mass="65514" checksum="E58931E4986882D6" modified="2018-09-12" version="1">MSYYIGVDVGTGSARAALVDEQGAVVAESAYNTTSFRDAKDANIFEQSTDEIWSCVSKACQDVLKSSKVSNATVKGIGFDATCSLAVCNLEDGSPVPVNPSAWSGEHHSGGPEGEPVHDIILWADHRAYKEAKDINATGSMVLKFVGGTISLEMELPKILWLKRHMPAALFQQCMFFDLPDFLTYRATGDLARSNCSLACKCSYVPPGVEGSKGWNDELFQAIGLDDFVKNEFKQIGGTPGKSGLILTAGQPVGRGLSAKAAAELGLLEGTAVGSGVIDAYAGWIGTVAAPMEGQKYTSLDDSKYRLAAIAGTSTCHIVQSLEAVFVPGVWGPYKHAIFPGYWINEGGQSSTGQLLDFMIDTHPASEKLKALAKEQGTNHFSLLTELLDAMAKDKGVPFISALTQNVQLYPDLHGNRSPLADNEMRGMLIGMALDKNISDLALRYYATGEAIALQTRQIIDEMNQHGHEIRSIFMSGGLVKNRFLMSLIADVCNIPVQLPHSHSASVVIGSAMLGAAAAAEAKTAESGLTTQEEAETGSHGMKERLWDIMLNSHPLGLQVRMSKPGTTVKPSASNQELRLLKVKYEIFKECIVLQRKWRSVTAEAMASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MGH5</accession>
    <name>A0A2X0MGH5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C017g08439 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C017g08439</name>
        <name evidence="7" type="ORF">BQ5605_C017G08439</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY20025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MGH5"/>
    <dbReference type="STRING" id="796604.A0A2X0MGH5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF13">
        <property type="entry name" value="MFS GENERAL SUBSTRATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY20025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="227" mass="24694" checksum="8104B85EE48DCB23" modified="2018-09-12" version="1">MSTPYATERTPLLSNPQHGESNPSAPPTSTTPPNPIASSSLLPPFRRLLLAALLQALSFVATATPIIFAFRTMSCEIYYERNPPYQGNGDRCARKEIDSTTASAISLMVTLTTFSGLLNLFTTGWIIRRRGVKLAMTLQTLVPCVRNVCQIYGIFHGGLLGIRLIQWTQLLTIFGGGGGYMLTANSYAAALVTPEERTASFGILQGFLMLGTALGYTRESDRKFFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHF9</accession>
    <name>A0A2X0MHF9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C011g06247 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C011g06247</name>
        <name evidence="2" type="ORF">BQ5605_C011G06247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY11717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHF9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY11717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="438" mass="48916" checksum="EA51D6B1100F6C42" modified="2018-09-12" version="1">MSSNRPTSSDHASFDELPPPSTASVHPPGQPPLARAVMSSSSAAPTAEEIKALIQQALDTASVPRVPAATSITFEAVNRLKDEATYPRWHRALKALVPTPIFSYLQTGNFPAEWSIATQDQWKDYVRSVLFNSLHPSIQDVYQEDDTPSQVYITLKERYSPRDAQAYAKLIQRFWSMPQIPLSSKNDFDKHLNHDLDLAREIRQGNLDIEQVLVAARLFSTNFNDGLDPWRETFLQLHQGKDRLPSLEETMKSMRVAAHNIIDKRPSAYVSNSDKSGTPPGPCPACKTGPLHWLRECTDEDAKKRFFSRPRPNRSKQNANAKPPAQARLAVASDDPGEISETAPSVSFAATSFLSVTSDSPSLLLDSAASHHMVNDSTAFVELHNTPPRRFNRQSHSPVQRLLHSGLSRESHLRIRAHQRRHHGFIHRRRTSLAGQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHH2</accession>
    <name>A0A2X0MHH2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C032g11085 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C032g11085</name>
        <name evidence="2" type="ORF">BQ5605_C032G11085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000067">
        <property type="protein sequence ID" value="SGZ04741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHH2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ04741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="227" mass="25266" checksum="184502E6A4740DAC" modified="2018-09-12" version="1">MVNSEVSLKPLLATNVPMIFTLLVSINFTETGHCFVYLRDILEEVAELTGLALQEDSCFDYWVVDDAATSSTHSTLCLASCLYDQLAAFTAATDSSDKVLGLTGFGLDIDSLPAEATITLRVYEHIKARLPFVNITTRPQRRVDAPVSSGAPSASKHDLLVREKREASPSNRISGNLRPNTEPDSRDDKCCNKDSEVLHDSAPRYTSEMMRIAWRRNPEGKKMQRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHQ8</accession>
    <name>A0A2X0MHQ8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C009g05412 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C009g05412</name>
        <name evidence="2" type="ORF">BQ5605_C009G05412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY80940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHQ8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="1">
        <location>
            <begin position="199"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal-type protein kinase" evidence="1">
        <location>
            <begin position="396"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY80940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="620" mass="69500" checksum="6AF4F4B28D905043" modified="2018-09-12" version="1">MYSTQKLPLPPRHSVMSHVQLGETRCSDEQRLAPLRCSASSTSQLVSRVSRLRSLGFSSGESNDGDREIEWAGLKDFFLAPLTDDIDTTVVPEIVWEDGKPTLKSRGRLLSFQEDNKNDLYDPEALPDVFLFTHEVIKANSNIEATWTSTDDDQWGGLCSGTQLAAVAEIGIRPIDASPHCDVVYPQDRLRHSLCTLVSHSCRSHVFGFAMYKHELKIVLHTPSGRFCAPIFKCTEANGHLSTFLARLLSLSDRDLGIITSLCEDAKPTSFRFPSSDLPPRPTSFDKRRRGDPRLDTIQILEPLYWSDSMFGRRTSAYRVSTGGEGPTAHTEYAMPVSFVEEARCDEHDRIRLAIANVSPDDRKGLTHIVDVYRESDFVVVPRFLPKMLDAKAWGLKPRAMEVVFHEHCFEPISVVESTEALAQVMLGAVQGLRSLYRLRILHRDVSAANVMIASDEKGLLIDYDTAVFMDGPKGEAERRKSVPWHEIESLVYVAIFVVFILPKGASDPAEMSNAARGLWEHWKAPITGVLTGNVLLTSTEALQSLFEPYVEHWKHVPELVAALTKYCGLGVQRAWNERVDERAPVEPRWATGELSHDRLASDLYALIERIVQNNTSESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJ66</accession>
    <name>A0A2X0MJ66_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C035g11455 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">BQ5605_C039g11749 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C035g11455</name>
        <name evidence="2" type="synonym">BQ5605_C039g11749</name>
        <name evidence="3" type="ORF">BQ5605_C035G11455</name>
        <name evidence="2" type="ORF">BQ5605_C039G11749</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000060">
        <property type="protein sequence ID" value="SGY89436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000064">
        <property type="protein sequence ID" value="SGY98289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJ66"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY89436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY98289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="169" mass="18363" checksum="83DDEA0346A9A9A3" modified="2018-09-12" version="1">MQAQQPQSTSIGAVGKSRGQKRPRESPSSQAPKRPRVRYERDDDEGEDVRGDLAVRGLPMTNNFVLVSTALRHSAMIDDPLCIVLGAFMAGMFARSAGEDAGSGSMSSEGTAKLRWRRSQADPTRLTRWLGLKSRASRALVSLPSSSIFHPQSCARTQPLESGSSPPYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJ70</accession>
    <name>A0A2X0MJ70_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C010g05894 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C010g05894</name>
        <name evidence="6" type="ORF">BQ5605_C010G05894</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJ70"/>
    <dbReference type="STRING" id="796604.A0A2X0MJ70"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03367">
        <property type="entry name" value="Ribosomal_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000007">
        <property type="entry name" value="40S ribosomal protein S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005680">
        <property type="entry name" value="Ribosomal_uS12_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003254">
        <property type="entry name" value="PRK04211.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00982">
        <property type="entry name" value="uS12_E_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY13566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="145" mass="15861" checksum="8A19D2B090FF758E" modified="2018-09-12" version="1">MGSCKPRGLLAGRKLRNSRRENRWADNNYKKRALGTAYRSSPTGGASHAKGIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKVTAFVPNDGCLNFTDENDEVLISGFGRKGKAKGDIPGVRFKVVKVSGVGLLALWKEKKEKPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJB3</accession>
    <name>A0A2X0MJB3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01005 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01005</name>
        <name evidence="2" type="ORF">BQ5605_C002G01005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY29047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJB3"/>
    <dbReference type="STRING" id="796604.A0A2X0MJB3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY29047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="914" mass="97880" checksum="687BB2D230C3B24F" modified="2018-09-12" version="1">MTTSTTPRLQNGPSVTRTVPSPALAGQGHVDFAESGGAAPPRTTTSSSAGEREQEVAQSAATAAQWLHASTSQLSDQTHVASTSRVAPQDAPDDLPTYAQIEKAEPSNPRFGRWAGWIEKRTRERSQDRMLSTQKSWGSQIGNADESHRHHTFNPCPDTTTRASADQSTMRRNPTQLPVRAHSRHSWAPTTPSSPIRSVSLSGAPAHSLTPSSAIQSLGSRFTQQFGEPPTCSVSLRNIIVAASGARATDESARLLLVGATSGLWLVDLASPRNEGQMEVFPMWDGMGIVQMELFDPNVQQESGVLLALVRRPTGGELELRMWSLTSLINLVRWRLTNTASTKLSLVAPTVSSPTQSTYNEKRRSRIVFKDLFLNKNAGFDRNGASEVASTNVAAPIRAPDDDFSSAGSRPNAPPSLDTPSSQSQLLALPLEWANASLVLPIPKSGGSLSFFKLCQVPVLTASSSSPPRKPRICLYLIIATSKSIFILNSAPPSSSSGSSRKWTACREFYSPATPRFVDLVKTNSFLPSFRAGFPTGTFPPRSARMVEDDLSLLLGMSSNIVLIRLVDSSVHEITIPIIRTRIHSRRSSFSVSHDSLGQASSTLKMGRSVSLQRKARAGVERAASMLMNYGKPSSSMTLRNSIPAGLSRDEARTLATGVKVDEVGAARFGEGLGRGGDDGWVGYTPVEGKVRAEQAQLFTRGRVTYLVTARKSPGSALSSPQPDLAPMPATVQAGGEATCATMNVLHTFVWPQIVRHVTISYIPAPTSGSTRAAEGRHLVLLGFSATGVHAQEGHLCLPRIAHYPSDDEISRPVWTPVSSAADILGTEGEVEAEATLDFGRDVIYLGSRRSAAAPSSRVDGRPSEEGASWWGNSSIRASNVGGTKSRLACSEAEKAGSFFAVQGVGDWSLKVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJC6</accession>
    <name>A0A2X0MJC6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="26">BQ5605_C029g10713 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">BQ5605_C029g10713</name>
        <name evidence="26" type="ORF">BQ5605_C029G10713</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ15942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0229">DNA integration</keyword>
    <keyword evidence="20" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="18" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="21" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="17" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="18" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="19" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="25">
        <location>
            <begin position="543"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="308"/>
            <end position="328"/>
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    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="801"/>
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    <feature type="region of interest" description="Disordered" evidence="24">
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            <begin position="856"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="915"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="801"/>
            <end position="819"/>
        </location>
    </feature>
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            <begin position="856"/>
            <end position="886"/>
        </location>
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            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
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    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
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    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
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    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="SGZ15942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1562" mass="170338" checksum="79E5383CE63B6592" modified="2018-09-12" version="1">MDSSDPTTPSFPRDPSPLASSITDQLATLQAQLAALQASQPPAATASAAAASQPTAAAAAATTASKVVFPKHARLDGSKSFTNWLRQLRLTLPNQIRGYVLDGVVPPTWTADQLAARDDAAREIIVGSIDSADVSATLDAIPSDDLSAPRIFAALKARFAPNDATRTLELFARLWDFRKMPASVEAYDTWLREYMAIAQEICDAKTSLNDVLAMVPSCLDSFRLTFTDEQRAQRELPELTTLTDRIRVQLRSAGLSASHSAMLADAPSCPACRAPGHRLRDCTSRAKHPPTGPCRRCQKRGHWALDCKNRGQQTRTSDDTQDDLSSSTAHRPNVGYFASCLFARRQLPTDAFVVDSGATTHMVADRSLFTTYRPTAHTKIGGIAGGITAIGMGDVPFVANTGHPITLRGVLHAPGLHVNLLSVSRLCDTDRVRLAFTSDSIDITKDGQAIAHGTRVNDGLYLLDADHTKCQQLAFLSRSESTVPLLTLHRCLGHLAPSSIQKMIAAGLLDGFGAGYSDKDVEEFVCNACLGSKGHRLPFPDSESHSPERLGLVHSDVLSFPTPSLTGKRYLVTFLDDHSRKLWAYAIDHKSDVFPTFQTWLAEVELETNARLRILRTDNGGKYRSNAFTEFCQSRGIRRQYSIPYTPQQNGHAERVNLSIVEGVLALLADSHLPATFWDEAAAYFVYCKNRCSHSALAKQTPQFVWNGQRTTATALHPFNCAAWLTVAPDLRSKLDPKAARMIFTGYDLASKAFRFFDHSTNKVVLGRNATFLDDNFPGLPVNMPVDADNAERQFVIPADAPAPDTADTHAPAATPAPAVKTRTPLVRSAHMDVSSPLDDSAMSAVDVAPGYTGGSLLNSTDTSPSSSPSLAPISSPATSSAGGPSIEDSDDPLDLLHSDTAVCLRLMDVHRSDDDTLVTPTPAVGPGQPSDDDSPDEIDLLSRHHRAFIATDDDDPTLEAIEPVKSITSDPQTWREAMSSNEHDLWAQAASDEFTAMRDDFKVFTIEPRSSVPPGATIITSKFVWKTKRNAQGDITGRKARLVAQGNRQRDGIDFSETFAPVARFSSIRCLLALAAANGYHVHQADIDKAYLHGELNHDIWMTTPRGFDFPSDQVLRLRRSIYGLKQAGRIWNRHIDTSLRSLGYTATGTDHCIYSRIDDQKQPHYIALYVDDLLIVSPALDEIERVISGLEQRYGVKRLGPAEYILGIQIRRLEDGSIALSQERYIMDVLARFHFDTTTRGATVPMTPGLSLTAVPGQGTERIRSWYLQAIGSLLYISLGTRPDIAFAVSYLSRFANNPGRRHWVAVKHVLRYLRATYRDELLYACGPAKITGVVGYSDANWGACVDTSISTMGFVFYLAGSAVSLSSKRQTRVADSTTDAEYLALSHAGKEAIYLTQLLSELHVRPVEAAHIFTDNEAAAAVAHDPVHTSGTRHIRLREHFVRDMVHQGDISLSHVGTANMVADIFTKALGPKIFGVHCYALGLRTRHPWLKSTSRSRGGGVRTGPGLRRAERAGRIGSGLRRAERARRIGPGLGARSEPGKLGACGSHTVSFLFITLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJG4</accession>
    <name>A0A2X0MJG4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">BQ5605_C020g09049 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">BQ5605_C020g09049</name>
        <name evidence="18" type="ORF">BQ5605_C020G09049</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000082">
        <property type="protein sequence ID" value="SGZ16644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="17">
        <location>
            <begin position="349"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="630"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="685"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="722"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="SGZ16644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1303" mass="143160" checksum="366C1FAE4161EE2B" modified="2018-09-12" version="1">MSDAGPSAPEAKLREPKPDAPPLRPPTHSAAFATTELLRNSSGYRDWVLAIRSRLPSGVVRYLNTGVPLESWPASYVPLWDHYACSSICASVDSQTVLPGLSPYLDESLAAPKVWQALRERYGTVSAVDLLPVIQRLFSSDPVPVTPDLFLQFRDSFENDTRLLQDSQVTVNALLASHLLARLPSSFDAWRTTFVADQGDSTAMPSATEIFTRLYRDVKARPVDTPVAAVATPQARHGCSRPCPNPSCRKLHWLRDCPDTAWAAAYRARRTAEKKASQPVASPTPCTPKALLAIPANVSLLTLHRRLAHLPVAQIKNIVQSGLVTGVDWVYKDQELRDFYCNACLASKAHALPFARSKSIASGRLDLLHVDVAQMPRPTFGGHRYMLVIIDDFSRKHWCILLALKSDVFPRLCDWILEVENATGHKVKTIRSDNGGEFTLRNFVDFCASKGIRRELTIPYTPQQNGRVERSNRTIKEGILALLYSSGADSRLWGEAALYYVHCKNLMPHAGIGGEIPDTRWHGFAPDISTLRAFGCRAWHHLPSAKRTDLDPKAVPLLFVGFDQHAKAFRLFEPSTRRIQLSRNVVFRESEFPALRPATDVRAEPIPLPVTVDAYPDQVDPLEPSLVASPRSLAPRAEPPRPVPAAPDQGPHRPAPAREVPDQDSLAPPAPDQGSLARELPDPESPASSASDQGSSNSAISTPCPSPRPVASRALPAPPSPARSDSPDPIDLLPRPRDVASLCQAQEFPDDVDDALHSPSAVAYLASGAAALIETSPADPAELIAPARDPPHWRAAMATPQADEWRLAARDEFDSLLRDFSAFTPIDESLVPADAKVLGSRFVFRTKRDQHGQVKSYKGRLVARGDSQRSGIDFDETFAPVAKFTSICALLALAAAHGYHVHQADIDKAYLHGKLDAPLYICVPDGIYMPGRVLQLHRSLYGLRQAGRIWNDEIDSALSALGYVATESDHCVYVRTMGDVHHYVALYVDDLLMISPSLPEIERTLQGLEQRYGVKRLGEAEYVLGIQIRRSPDGSISLSQEQYLKDVLARFGMSDAHPVATPMQPDLRLEVELQPTPFPDRTRYLQAIGSLMYASTGTRPDLAYTVGYLARFSHSPSAAAWGAVKHAFRYLAGTLSHGLRYARGNPAPLLGYSDCNWGACVLSSKSTMGYTFVYAGAAVSWSSRLQSRVADSTCDAEYLALSHAGKEAIFLRQLFGELGLSSSKPVLIYGDNQGANALTKNPVFHARTRHIRLRKHFVRDMVSMGDIVVQYINTGEMTADIFTKALSRDLFARHRGRLGICAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKP3</accession>
    <name>A0A2X0MKP3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">BQ5605_C022g09451 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BQ5605_C022g09451</name>
        <name evidence="16" type="ORF">BQ5605_C022G09451</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MKP3"/>
    <dbReference type="STRING" id="796604.A0A2X0MKP3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="15">
        <location>
            <begin position="47"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SGZ22201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="224" mass="25688" checksum="DEEF633FED9546A9" modified="2018-09-12" version="1">MQGRGFHANIPKGPASRADKPLHAIHVDLWGPVRHESFSGEVMALGLVDDYSRFRWSVPIAKKSDVTTIVIEFIRRMERSRDGTFFFKDRGIEHRTTVPYAHYQNGVVEPGWRTMFETVRIWLLVSGLPLSRSFWAFASNAFTYVSNRRTTAALPGSTPFEMYHLRKLNVLRVPVWGCVAYVRIAPERRPSKIEPPRVKARFIGYADQGWMFCISNGTGREQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MM52</accession>
    <name>A0A2X0MM52_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C020g09088 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C020g09088</name>
        <name evidence="5" type="ORF">BQ5605_C020G09088</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000082">
        <property type="protein sequence ID" value="SGZ17028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MM52"/>
    <dbReference type="STRING" id="796604.A0A2X0MM52"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US17M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="35"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGZ17028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="172" mass="18593" checksum="EC8138BAF92EA3F3" modified="2018-09-12" version="1">MSLLIRRAVTTTLPSCTCSTTILARRTTLLSSALHTSSSSSSSSTASTSTSTSANPAPSSTSPPPPPSRYALPKGLVLNGLVTQAGVAAQTTTVTVERQQTHHKTLKAFKTHKKYLIHDPLSQCVIGDRVEIRNCKPVSKRKRFELIKVLKASRQRESAARVIAQQEREEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MMA7</accession>
    <name>A0A2X0MMA7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="10">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C012g07029</name>
        <name evidence="12" type="ORF">BQ5605_C012G07029</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="10"/>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MMA7"/>
    <dbReference type="STRING" id="796604.A0A2X0MMA7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF3">
        <property type="entry name" value="HOLOCYTOCHROME-C SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="16"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY16922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="306" mass="33907" checksum="B291803DAE5DCE85" modified="2018-09-12" version="1">MHEPFKVSVAVDELVATKDSPQPTSCPVDHASLQRLSGTTPRTRPQGEFNPTNNIPELAQARSPGQKMALPLERTMSSIPKPSAGAGSAAGPSACPVAHGSGDSAPAPTKPGQWEYPSPQQFYNALVRKGWETPEESVEIMVDIHNWINEEAWAQVRRWEEKHDGGSRSMLARFQGRPQDLSPKARYHLMMGKLFPNYYGSVKPFDRHDWLVHRPIPRDSSSGFTAPSSTQNYTEHRYVIDYYSLPEDAQGNPVFSLDVRPAVDSIEAVQDRLAEWWKVKKEAWMSGSAASVSTPDSSPGVRVQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MN16</accession>
    <name>A0A2X0MN16_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">BQ5605_C026g10267 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">BQ5605_C026g10267</name>
        <name evidence="18" type="ORF">BQ5605_C026G10267</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ28063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="17">
        <location>
            <begin position="384"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="665"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="720"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="757"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="SGZ28063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1320" mass="144646" checksum="14F383718557CDCD" modified="2018-09-12" version="1">MSDAGASAPEAKLRGPTPDAPPLRPPTHSAAFATTELLRNSSGYRDWVLAIRSRLPSGVVRYLNTGVPLESWPASYVPLWDHYACSSICASVDSQTVLPGLSPYLDESLAAPKVWQALRERYGTVSAVDLLPVIQRLFSSDPVPVTPDLFLHFRDSFENDARLLQDSQVTVNALLASHLLARLPSSFDAWRTTFVADQGDSTAMPSATEIFTRLYRDVKARPVDTPVAAVATPQARHGCSRPCPNPSCRKLHWLRECPDTAWAAAYRARRTAEKKASQPVASPAAVDTPNSVIARPSGAVVATAQAIGNNLYALALGPTPCTPKALLAIPTKVSLLTLHRRLAHLPVVQIKNIVQKGLVTGVDWVYKDQELRDFYCNACLASKAHALPFARSKSIASGRLDLLHVDVAQMPRPTFGGHRYMLVIIDDFSRKHWCLLLALKSDVFPRLRDWILEVENATGNKVKTIRSDNGGEFTLRNFVDFCASKGIRRELTIPYTPQQNGRVERSNRTIKEGILALLYSSGADSRLWGEAALYYVHCKNLMPHAGIGGEIPDTRWHGFAPDISTLRAFGCRAWHHLPSAKRTDLDPKAVPLLFVGFDHHAKAFRLFEPSTRRIQLSRNVVFRESEFPALRPATDVRAEPIPLPVTVDAYPDQVDPLEPSLVASPRSLAPRAEPPRPVPAAPDQGPHRPAPARVVPDQDSLAPPAPDQGSPARELPDPESPASSASDQGSSDSAISTPCPSPRPVASRALPAPPSPARSDSPDPIDLLPRPRDVASLCQAQEFPDDVDDALHSPSAVAYLASGAAALIETSPADPAELIAPARDPPHWRAAMATPQADEWRLAARDEFDSLLRDFSAFTPIDESLVPADAKVLGSRFVFRTKRDQHGQVKSYKGRLVARGDSQRSGIDFDETFAPVAKFTSIRALLALAAAHGYHIHQADIDKAYLHGKLDAPLYIRVPDGIYMPGKVLQLHRSLYGLRQAGRIWNNEIDSALSALGYVATESDHCVYVRTTGDVHHYIALYVDDLLMISPSLPEIERTLQGLEQRYGVKRLGEAEYVLGIQIRRSPDGSISLSQEQYLKDPDLRLEVELQPTPFPDRTRYLQAIGSLMYASTGTRPDLAYTVGYLARFSHSPSAAAWGAVKHAFRYLAGTLSHGLRYARGNPAPLLGYSDCNWGACVLSSKSTMGYTFVYAGAAVSWSSRLQSRVADSTCDAEYLALSHAGKEAIFLRQLFGELGLSSSKPVLIYGDNQGANALTKNPVFHARTRHIRLREHFVRDMVSMGDIVVQYINTGEMTADIFTKALSRDLFARHRGRLGICAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNB4</accession>
    <name>A0A2X0MNB4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C014g07449 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C014g07449</name>
        <name evidence="2" type="ORF">BQ5605_C014G07449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY18707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MNB4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY18707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="885" mass="97920" checksum="BB07BD1BA4B7560F" modified="2018-09-12" version="1">MIGCLQHYKASVNRHSTLRLLRNDTGTDTEALQDLQNEFATMAWSLTKARTPRAAAAIAESITKRWPMLRHWCAFWTLPRILPMISRALSKMTPEERRLYPTTTNAVESAHKCLLHASASSNNKPAKGVHRVLDSVQFFIGLQVVAKTGNFTGSRLRSKGSDEDEKRVTAAARAVEKRKQVPRSYVPSGRPLDPFEAENRRPISHKAFMDKALLDSDDVMIVEVAVNSEYQNPPLLELVNDIVVEAAAEVERSSAPLENAAIPDPPSTKPTVEEEPRGTAAPPLAKAKGFVRTAPRRARNYLIKPVDPAAVVSGVRSSPNAPLASSTVMSQVHSMVNTSLLLVSRVTGTPFGTFAPDAVGVLQTSNNQNSCWLDSTLMAMMASWDALKGFLVSLEEPLRSHTNEGSTAGSPIVEVYNALRDFFRTYAGTIDDKASMTTAATRIDPSRDELRRLIKASLLAPGHGDHKTTGYANAVEWWQHLASLLFKLSKTTLPPQSTRMAETDWVLDVSLSNTVRWTPDDRSSDLVFRDDTGLEHRWSLRAVTQLRHQHISTKGGVAIGPDGELQWHQFDGLNPMGKPECAAITQCLSNKAMDGLAGIDDYRPRAICCANGRLLPIVAMVRQRYEVMGLELGVVEEGAQAGRQTCKKIREAGSARKYQIDKLRILEKAIGLHPGHSLFDEYRAHKPVMVKLRCPTCAAGGLCGTPVAFTQDLIRCNLCGLYLHKLRAEISKEEQRTTRCIICVNVVSTKDLRADELKKLSGTVNLQLVPGNKLAWSFSNAKQLAGIKNREIYLSLQVPTEAILKKTWGTNASLVKTFIKDTKKTFKHLNKLAAERYADNYSDEDGPVRHHYFPMLQKWYLFAMPLVQIIPLGGHTASCRTMTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQ54</accession>
    <name>A0A2X0MQ54_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nitrate reductase [NADPH]</fullName>
            <ecNumber evidence="7">1.7.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">BQ5605_C016g08109</name>
        <name evidence="22" type="ORF">BQ5605_C016G08109</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>nitrite + NADP(+) + H2O = nitrate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19061"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the nitrate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.7.1.3" evidence="7"/>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY20627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQ54"/>
    <dbReference type="STRING" id="796604.A0A2X0MQ54"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050464">
        <property type="term" value="F:nitrate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.420.10:FF:000005">
        <property type="entry name" value="Nitrate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022407">
        <property type="entry name" value="OxRdtase_Mopterin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF7">
        <property type="entry name" value="SULFITE OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00559">
        <property type="entry name" value="MOLYBDOPTERIN_EUK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0274">FAD</keyword>
    <keyword evidence="11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0349">Heme</keyword>
    <keyword evidence="16" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="14" id="KW-0521">NADP</keyword>
    <keyword evidence="17" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="20">
        <location>
            <begin position="600"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="21">
        <location>
            <begin position="699"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00015499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="SGY20627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="971" mass="107663" checksum="C0B19BAAC69D962A" modified="2018-09-12" version="1">MSSASLSSLTSSDSEDLQSQGSAASTAPTSLAATPAPSSPKQSSNALSFTECRTSAPKEPDHFNSLPSPFYPASLLSAEEKQEHLLPALPLEYPALPATTRPEQPCDADRGTPDEWIVRDEKLVRLTGKWPFNCEPPLPDLWKSGFLTPTRLFYVRNHGVVPKVSRQDAEAWTFDIGGLVKRPCTLSLADLLDPSRFNAVTLPVTLVCAGNRRKEQNVVRKSLGFSWGAAGLSTALFTGVYLADVLDYVCPQNEGKIGQPGFKRAEHVIFEGAEDLPNGKYGTSQRLRWARLREKGMMLAWAMNGEALEPDHGYPLRLVVPGQIGGRSVKWLKKIIVSDKESDHHLHYWDNKVLPTTLMPEQARSERQWWYDPRYIINDLNTNSAVACPAHDEQLVVPVPTEANPSPTYTVQGYAYAGGGRRVTRMEITLDDGDTWSLCDIRYPEDDYRQMPFSAPVWGTLDITDRDECFCWAFWKIEIPIEKLKDATSIAIRGMDEGLNLQGKTMYWNPTGMMNNCWFRVVIHSSMSETGETVLRFEHPTMPGSQPGGWMERMKDNGEDILRPQFGVVPTGEESEILLQSKESAKLKKSTVVMTKEGVTRKITMTEVQAHNKESEPWFVVKGEVYDGTGFLAKHPGGAESITLVAGEDATEDFTAIHSIDAKAQLADYHIGTLVVEEAPSAVVPSTPTLPDPIFLNKSKWKAATLISIEKLNHDSRNYRFALEYPEQQLGLPTGQHVYARLRRKVSPGDAEDKGGVPIVEGELVQRAYTPVSSNTAQGFLDLLIKVYFRTPDFPEGGRMTLGFDELQIGDKVEFKGPLGSFRWLGKGMCNWKGVKRRARNIGMICGGSGITPIIQVMRGIIHDSEDIDTNVWVLNANKTEADILLRAELEELGKLVGPSRCRQHLVLSKGPADWAHSKGRINKQMLIDHLPPPGPDSLVLICGPDPMINEIIKPGLAELGWDVPNTLVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQQ7</accession>
    <name>A0A2X0MQQ7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C026g10266 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C026g10266</name>
        <name evidence="5" type="ORF">BQ5605_C026G10266</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ28062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQQ7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF463">
        <property type="entry name" value="REVERSE TRANSCRIPTASE TY1_COPIA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="222"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="408"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="438"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="451"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGZ28062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1218" mass="134749" checksum="5F2D19DBEE4D8C82" modified="2018-09-12" version="1">MPRFPWIIDSGAKVHCVGDKSVLSDVVSEPLKISVANQSQIESPGHGSVTFLTSYGARITIKRVYYMPGAQCGFISIDRLLELMTYAVGPQSNLIFSIRGKSILRSLPGRGFVMDAAPVQPIMSSSPPSMVGANRLTGTCTLMEAHRKLGHQSPAAIVLAVKSGAITGITLKDEKVTPCFSCIQAKSKRSPFSNKSTEAPHALYRVFIDLGFVEHPNHHGDTIYLAIVDQYSTAKWTIPSPSVKRVRSDNGREFDNSLFRALLEKQGIIVEFTAPYPPEQNGQVERLNGSLMGLVRSMLLDSGLPMRFWSDALAVATFVLNRRPHPRIQGKTAIEVLLGKKPSLAHLQPFGSTVFVHVPKERRSKLAPRSIQGVFIGCSGEYNYRVWVQSSKQVYVSRHVTFLETPSVVTSSQDRADASDPVHHSRPPHPPHPPPDVLPSTPTSPVVDPTLPDPQPPPVVPIGVGQQGRYLAVVPQEPLDGEAEVALAPREGYAIVRTGPNPGQFENVDPSNILPAGSRRRPQPLENILLIISAIMVDVLDTPPMFHDKLSYDAYCAAVFAEEDIEIPKTFEEAMKSPYRNHWSAAMVSELLQFDHHGVFQEVKWHEGIWVLGTIWVYSIKRDANGKIIRFKARLVAQGFAQRPGIDYHDTYAPVARSSTILFLIALAAAQGLYLEQFDFDCAFLNGKMTEDVYVRYPKGWNRPQSPGKCLKLVGSMYGTKQAPHEWATADACLYIKHSGTSFAIITLYVDDGLIASNNQSFLDSELGSLHKAFQLKHLGPVSYFLGFEIHRTKDYILVHQSKYVRTMLEKFDFASPSKRCAITPMDDRPSLQINATPFADVSLYQSAVGSLQYASTRCRPDIAIAVRAVAQKNSCPTVDDWAAVKRIFRYLNSTIDLGILYRNSSTTRLMVYSDASFADDPESRRLVGAYASMLAGGVISWQSKQQSMIATSTTEAEILCASSATREAIWLRRLAGDVGIPQAQPTIIQEDNAACIQIAKDPVELEYCPTHVNAADIMTKPLGFQRFDQLRALLGMVSLVSLTGGSVRKHHLSYNALREGFESAWPGACIRFAPHVLTLIPDGSPLAGRLLSSTPVVFAEAPQFDGRILRSVFRLEELNIEIINMYAPVKGEERRDFYGLLHFTAPGPKTLRILAGDLNDCPDVSVDRVAITDRAWTPVLHWQTLLSKIAFNPLDTIRQLHPITPAFVMLSRLLKQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MR12</accession>
    <name>A0A2X0MR12_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C026g10214 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C026g10214</name>
        <name evidence="2" type="ORF">BQ5605_C026G10214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ27886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MR12"/>
    <dbReference type="STRING" id="796604.A0A2X0MR12"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="1">
        <location>
            <begin position="1181"/>
            <end position="1267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ27886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1267" mass="139246" checksum="D958DD7F3487E80D" modified="2018-09-12" version="1">MSLPPLEKDNPIPCSLKRTVDAIKLVDAALSADMLTEDARRDLITKLSLEACSTRNHPSGDIKLVFWLGQLRAIPTDTLLAINNLSELHPVIAHALVSGDGYYRKRATLAALTTPDAPLAEGAFHVAQAVPAAAAVPRPPSIVMIEGVGEVPSYHLNALPRGTDGIVIVEKRLFVFSTQFDATQFPVGCLAQLVTSPRGMLVSTQDAIDDEEHNWADVESERMEQLMRLAGSPAPAPAPARPPIHRAQMAPLQAHLAPPTQQYPSVYQPTSPAIHVPTAEPADDEDRRYRLERLNAAHAAPAYSADPKTAAGIIRLKLQRQGEIKMDVIEVMKIMCGAYIDVCDIVHPQEAELFDSYTDENGIEFTGIQARAQRKASKVKTPVTDFPEYLRALKEIQAVENEVFGTWAGADWSHYLKFLDDMHAGVHSGMKGSKLPIAFDEHFRTLRSEPSATVTSLLEANASHSVYVNIIIKVATLASQLSTQPALEERTFRKHHLPSASGPAKKRSTLSKIDWICMRFNRGQAHPVETCRLEHICWDCETEGHRSGDRICSNLKAGIGGRLAQMAANSEDQVPLLPHTLPPPGHPPPSLLTGIGPAPRIQHQFHFEAPTSDPPSTPLLTSSATGLAGPLARATFTPAQLHSIQRAQRMYPSQFNFVRTIKDDLFETLLCSHPDQDLVQSFVLGFRSEGFEPEHDGSVASGDDPSTINFPCSETHQSFIQSTIDEEVGKGWLSAGMSFPIPGATYSSVFVVESTNHRMCVVADHTRSGLNDGISRAALLWKLDVSSAFKVLVMSKNWQARQGIAIKRRLPDGDLVTWYHIEWHGVFGCRAMPYLWTRFMLLVVWIAQQSYGIKYPLAYMDDAFGVDVSGTLVPFVHNGVQYIIPSQQAQMADLWQSLGLPFKLSPGKAPFGWQVTITGINCDLDDFSISLTPKAIDDLATVIQAFLDFPGRCPPLRQWRQMTGWLSWALNVAPQAHPHVTPLYNKTGSKTWANTGVPLNLKVRELLASIARLLAATPRLDLNATSLTRWSIDDADLVIYTDACLQNDDHTGAGLGFWFTLPGGCHYFATHPGRTFERIQFAEALTVVIALDIATSGAFGSFQRVLVRTDSAPAVCALDSGACSDTPFLPLRTLTLRAFTISASHRFDLNVQHVVGDAVMTTYRPGGGRGVSFASRPLPGPSLRGLVHPLSDDLEFSDELVLRALEPRTRSDYQRSLRQWLTYVQVQNDMGFNISCHPTVSTLRAFIAHRYRSVTAVHQTLSGLAHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-11-27" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MRC6</accession>
    <name>A0A2X0MRC6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C055g12644 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C055g12644</name>
        <name evidence="1" type="ORF">BQ5605_C055G12644</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000092">
        <property type="protein sequence ID" value="SGZ29199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MRC6"/>
    <dbReference type="STRING" id="796604.A0A2X0MRC6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053228">
        <property type="entry name" value="Stereospecific_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37574">
        <property type="entry name" value="LIPASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37574:SF1">
        <property type="entry name" value="LIPASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ29199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="314" mass="33249" checksum="DE68A247370E7A00" modified="2018-09-12" version="1">MMRVLRGRTRSGELPFVTDRAFGYLLLLVHGTGSKGSESWAFGPYVRILSITGKQYNPCYIDLPDRSLGDAQVTAKYVVAAIKLLAPRSTTKKVAVIGHSQGAGLNIPWALQFWPSTQALVSSFIALAVNFHGTGRSKLLCGAAVSYCGPSVTQQTTGSRYLAAQNSPAMGSARSALVPTTSIFTRYDDVIQPEGPTNAQATSFLLGASNFALQDAQVCGPGHAASHITMLTDSAAFGLAKAALENPTMPAFDQSYCFQIRENPAGRSAGFGSLLSGGMSDRMAISRSRFGEIGAEPALKSYVCKRGFATQCAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MRE0</accession>
    <name>A0A2X0MRE0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C001g00642 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C001g00642</name>
        <name evidence="3" type="ORF">BQ5605_C001G00642</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY48329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MRE0"/>
    <dbReference type="STRING" id="796604.A0A2X0MRE0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11524">
        <property type="entry name" value="SYLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF40">
        <property type="entry name" value="YSC84 ACTIN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ysc84 actin-binding" evidence="2">
        <location>
            <begin position="371"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY48329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="532" mass="57608" checksum="A32E429118737B58" modified="2018-09-12" version="1">MTMDSRGEAKGSVASRPAVRLVPTPPSSSSSSSSSPNLDSHSNPTSLNLHLAPIPPPPKRLVRDPPKAYTPYSDAMPPTKEGLSGWFSRHGKQKGTVALEKGIAWSDWLGVKMNGWAEAVSFWCITPLQSRAVLRGTCLLPWAPSAPRADRARQRVSADARCLDPYAGAETRLCGYWWQQACGKSREHWQPPPPPPSTPLPRSVSTLPQTGSERFYPVTGDFTAELEKVTRILQSFTVDGVEGAVDVESKTASGAPRKVQKKVIRKIPAKVIREAKGVAIFTSMRSGIAPLGGAGGAGMVIARLEDGSWSAPSSMSPNNLSFGLMLGVDIYDAVLILRTAEVLDAFMGRRFTKSMPHTRTRQNADRSLATSPDTVTLGAELGVAAGPYGAGAVAETGKSRVPILSYLRSRGMYAGVEAVAQIYVTRSEENENAYFWPGITPRDILTGKVRAPREAEALHQALEAAETGEAQRANGDEFEFEQPFFESENLAVSLGEGEVLRLPPTPAQVEEEEAEESRDEAIKVRSEKRYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MS51</accession>
    <name>A0A2X0MS51_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C001g00932 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C001g00932</name>
        <name evidence="4" type="ORF">BQ5605_C001G00932</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY50847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MS51"/>
    <dbReference type="STRING" id="796604.A0A2X0MS51"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033934">
        <property type="term" value="F:glucan 1,4-alpha-maltotriohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004574">
        <property type="term" value="F:oligo-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000025">
        <property type="term" value="P:maltose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11333">
        <property type="entry name" value="AmyAc_SI_OligoGlu_DGase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000004">
        <property type="entry name" value="Oligo-1,6-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF179">
        <property type="entry name" value="NEUTRAL AND BASIC AMINO ACID TRANSPORT PROTEIN RBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="3">
        <location>
            <begin position="16"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY50847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="542" mass="62711" checksum="075C18252F900D5A" modified="2018-09-12" version="1">MIVHDKRWWKEAVVYQIFPRTFKDSKGQGDYGDIQGIISKLDYIKKLGVDVVWVSPFFKSPQIDLGYDISDYQDVHEPYGKVSDVEELIAGCHERGMKVLFDLVVNHTSDLHPWFKESRSSKDNPKRDWYMWRPARCIDGVRQPPCNWKAAFGGSVWEWDEPSQEYYLHYFAVEQPDLNWENSEVREAIYSEVCRFWLDKGCGGFRIDTANLYSKHLDFPDAPIVDPYQPAWKLVCNGPKIHEFLRELRKETWGRYDAMTIGECGETFEIEDILKYVSKEAAQLDMIIQFDLVNIDHGSRRFQFLPQEWKLSQFKKITRRAQELTDPKNEAWAAIYLENHDQGRSVPRFANASPAHRVNSAKLLATYLLSLSGTPIIYQGQEIGMINCPESWEIEKEYKDVLTVKMWEEIKHAAEAENDPELLAQGRKGEINVAAQEGVAESPLEHYRRLITFRKQHPDATVYGGIEILDLEGDETMLYLKRAKHGQALFFALNFTADEQAFELPIVDDIEFEIVQELKYGKGQAGKILGPYEAQVFVGRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MS96</accession>
    <name>A0A2X0MS96_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C052g12561 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C052g12561</name>
        <name evidence="25" type="ORF">BQ5605_C052G12561</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000099">
        <property type="protein sequence ID" value="SGZ29911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="416"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="655"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="757"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="664"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGZ29911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1301" mass="141966" checksum="BE5342138AA9D255" modified="2018-09-12" version="1">MSNPAISTRHATCATREAGRNGSTTSKPNARTDLEHANFQAIALLRRSVSLNIKKQIKDGFDHTPTDVLKMIKKAVAAGTVTDIFIKLQALLDAGPPPSGVDAFEKYQANTIELFNTLSGYNLTFDQVISIRLIHFGKDLYKEYYTQTLRQDLDKLPDPIEALQTLQTQAESTPAHKPVAMVASLTATDRSSSTPSAPCRHCGGPHWNRKCPVKDKKSKASSAPSASLAAAPDISTLVNGPVRGYLTAAMSTLAKPSLILDSGATHHIVNDRACFTNFRKCKPAPLEGITGEAVNSIEGVGSAVVRSFDGSIGQLHHALFVPSAPVSLFSASRANAAGYDINLSRGKATVSVDGSICHTGEITNGLYHMHASLVDVTTLIEQPVNMEVALNADLKCDTCQAGKITHHPFPTVASNRSAQPLDRVHMDLLAFDGAVSLGGAKYALVIVDDYTRYLWAIPMSHKSDTFAAFKSWLAKVERSSSRKLLAVRSDNGGEFLSNEFSSFLEEQGITRQLSIPDTPQQNGVAERANRSITEGVRSMLHQSGLSHALWAEALATYVYVKNRSPHSANSGVTPHTRWHGSKPSAGHLRVFGCRAWKAATTEARSKLDPRGIPLVFVGYDLESKGYRLFDPATRQVFKSRSVTFFEDEFPARREGITAAHAPVDDDDDDDDDDEVVVLPDQHANQAPPDQAELPAALRFDAPGPAWQPPVGSRPRNPPARYGALASLRSTPSAFAFSLGKEVTELVADLEAAGIDTSTANRPLSEPEDPFSLPSSDPTTWNEAMRHPHAAAWKAGAIEEFRSMKDDLKVFSVVGLSSVPKGATILPSRHVFRTKRDKAGKMVSLKNRIVAQGCAQGPNSFNNTFSPTAKYTSIRTLIAHSASKGHHIIQADVDKAYLHGVLEEEIYMRVPTGIEGYEGKCLRLHRSIYGLKQAGRVWNDTINATLASLGYRRLACDECIYRHEDAGGDHYIALYVDDLLFFGPDLGEIDRVLDQLDTLYGVKRLGPAEWVLGVQVVRHDDGGISLLQRQYLLDVLARFNMSDCNPCKSPMEANLQLSPEPDTDSADNAIYRSMIGSLMYAVVATRPDLAHSVGYLSRFVGKAGDTHLEAAKRVLRYIKGSLDLGIHYTRTSAPLLGYEGYSDSDWGSDIQTSRSTMGYLFKLAGGAISWSSRLQPRVACSSTEAEYLGLSHAAKEAVFLRSLLTELGLDTSSPLRLLGDNQGAIALTQNPVFHARTKHLRMLEHFVREHVRNGEISVTYIPTHDMVADIFTKPLPRVVFQRHCDAIGLRRISGQEQGGVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MSJ0</accession>
    <name>A0A2X0MSJ0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C002g01057 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C002g01057</name>
        <name evidence="4" type="ORF">BQ5605_C002G01057</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY29480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MSJ0"/>
    <dbReference type="STRING" id="796604.A0A2X0MSJ0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="210"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="342"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY29480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="414" mass="45949" checksum="B68E4053BFA04920" modified="2018-09-12" version="1">MSSATWLQPPQATLDATRAFKPFLDTLVIAYFTQVFILGMITAKAVTYFSRGSRDPTIVKSARAPRWFFRGRFPLLVADSSTPCFWRLYRVCVAFSVLILWCKSGLDIKTIWNSAFFLPYRHLNPALPWSILTSLSISQIPVALSQVYLCYRLWSISKNHFLSNAIAMAGTLCSTILFIIYVILRVKYPVRRDIQDRAHAWIPPWAFCTCFTDIYLSLASTYYLLQTRKKAVGYQLDYMLLRLASLSITTCLPPALMSAIMAILEIVKSTGEAWAFFTIIIASVYVLCILHSLNSRQEIREEARSRSTMKNPSPLTPGPSRIEAPVQTLTNSKAVELTQPYSPKSKPSSQLPNQPLGRNDGPKTSESPHGNGGSVGRKLLSDRVRGPSPSVAAGCATPEIEGWLSGSESGQCGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MTI3</accession>
    <name>A0A2X0MTI3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="28">BQ5605_C044g12142 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="28" type="primary">BQ5605_C044g12142</name>
        <name evidence="28" type="ORF">BQ5605_C044G12142</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000114">
        <property type="protein sequence ID" value="SGZ31315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0229">DNA integration</keyword>
    <keyword evidence="20" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="18" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="21" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="17" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="18" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="19" id="KW-0917">Virion maturation</keyword>
    <keyword evidence="24" id="KW-0862">Zinc</keyword>
    <keyword evidence="24" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="26">
        <location>
            <begin position="295"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="27">
        <location>
            <begin position="544"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="857"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="915"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1485"/>
            <end position="1532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="857"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="SGZ31315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1532" mass="167058" checksum="BD01538A4B66E4D0" modified="2018-09-12" version="1">MDSSPASPLAPRDPSSPESSIGEQIATLQAQLAALQASQPAAAAAATPAVTAVPGNAATASKVVFPKHARLDGPKSFTNWLRQLRLALPNQVCGYVLDGVMPLTWTADQLAARDDAAREIIVGSIDSADVSATLDAIPSNDLSAPRIFAALKARFAPDDATRTLELFARLWDFRKMPASVEAYDTWLREYMSIAQEIRDAKTSLNDVLATHVLAMVPSCLDSFRLTFTDEQRHRRDLPELTTLTDRIRIQLRSAGLSTSHSAMLATSSPCPACRAPGHRLRDCTSRAKHPPTGPCRRCHKKGHWALDCKNRGEQARRSDDTQDDTSSSAALQPNVGYFASCLFARRQLPTDAFVVDSGATTHMVADRSLFTTYRQTAHTKIGGIAGGITAIGMGDVAFVAKTGHPITLRGVLHTPGLHVNLLSVARLCDTDRVCLAFTSDGIDIAKDGQTIAHGTRVNDGLYLLDADHTKCQQLAFLSRSESTVPLITLHRCLGHLAPSSIQKMIAAGLLDGFGAGYSDKDVEEFVCNACLGSKGHCLPFPDSESHSPERLGLVHSDVLSFPTPSLTGKRYLVTFLDDHSRKLWAYAIDHKSDVFPTFQTWLAEVELETDARLRILRTDNGGEYRSNAFTEFCQSRGIRRQYSIPYTPQQNGRAERVNLSIVEGVLALLADSHLPATFWDEAAAYFVYCKNRCSHSALAKQTPQFVWNGQRTTTTVLHPFGCAAWLTVAPDLRSKLDPKAVRVIFTGYDLASKAFRFFDHSTNKVVLGRNATFLDNDFPGLPVNMPVDADDTERQFVIPADAPAPDTADTHAPAATPAPAVKTRTPLVRSAHMDVSSPLDDSAMSAVDVAPGYTGGSLLNSTDTSPSSSPLLAPISSPATSSGGVPSIEDSDDPLDLLHSDTAIRLRLMDVHRSDDDTLVTPTPAVGPGQPSDDDSPDEIDFLSRHHRAFIATDDDNPTLEAIEPVKSITSDPQTWREAMSSDEHDLWAQAASDEFTAMRDDFKVFTIKPRSSVPPGATIVTSKFVWKTKRNAQGDITGRKARLVAQGNRQRDGIDFSETFAPVARFSSICCLLALAAANGYHVHQADIDKAYLHGELDHDIWMTTPRGFDFPSDQVLRLRRSIYGLKQAGRIWNRHIDTSLRSLGYTATGTDHCIYSRIDDQKQPHYIALYVDDLLIVSPALEQRYGVKRLGPAEYILGIQIRRLEDGSIALSQERYIMDVLARFHFDTTTRGATVPMTPGLSLTAVPGQGTERIRSWYLQAIGSLLYISLGTRPDIAFAVSYLSRFANNPGRRHWVAVKHVLRYLRATYRDELLYACGPTKITGVVGYSDANWGACVDTSISTMGFVFYLAGSAVSWSSKRQTRVADSTTDAKYLALSHAGKEAIYLTQLLSELHVRPVDAAHIFTDNEAAAAVAHDPVHTSGTRHIRLREHFVRDMVHQGDISLSHVGTANMVADIFTKALGPKIFGVHCYALGLRTRHPRLKSTSRSRGGGCEESTLRSAQDLGARSEPGASAQDLGARSEPGASAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MTY1</accession>
    <name>A0A2X0MTY1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C002g01587 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C002g01587</name>
        <name evidence="4" type="ORF">BQ5605_C002G01587</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KRI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY34082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MTY1"/>
    <dbReference type="STRING" id="796604.A0A2X0MTY1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018034">
        <property type="entry name" value="Kri1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024626">
        <property type="entry name" value="Kri1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490:SF5">
        <property type="entry name" value="PROTEIN KRI1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490">
        <property type="entry name" value="ZINC FINGER, ZZ TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05178">
        <property type="entry name" value="Kri1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12936">
        <property type="entry name" value="Kri1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kri1-like C-terminal" evidence="3">
        <location>
            <begin position="637"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="380"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="437"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="522"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="694"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="23"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="437"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="457"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="528"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="545"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="568"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="595"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="716"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="759"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY34082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="785" mass="86993" checksum="04199F5DB97CD3E0" modified="2018-09-12" version="1">MARKPKSTEAASTSKLDKPTPAPSTATATAGLLSDSGSDSDSGSDSDSGAGSSSSASSASSKGKKKKENKSKDRLSLNQSFATSYKLKKQTEELSKLQDKYGTKLDQLSSNDEEDSEASTVYSDDDSCAELVTPQVDVAIFKTLAKIRNKDPEVYEPQKMVFAEEEKGLASTSGTASTKPKTSSSKPVLLKDYQLQRMLADPTHSQIDDESIPDASFQPPTYAQQEQALKEQVKQAFFQANGSDDQDDGDDDDAFLVKRTQTKDEAQKEQDEYTQFLKTNLGAKAVKEALHEEEEFLNESVCTDSLSGKHLEADPETRSLLSYLLHRGWIDPKAKKNRIPSYKEITGGNDDFDDEIEHVQSLAKDGKKARQLLAESIKAGALKAERAEGEEEEEDETRLDPGLHDSSDSEFEEQAEEFEHKYNFRFEEAQGADLVTHSRTAMSSLRKPTTATTARQRAREAAKAKKEQEKLERKEEVRRLKALKRKEVEAKLAKLIEAAGEGTKGLDAIDLEGDWDEAEHDRKMQEIYGEEYDQGDDEGFKPTWDDDIDIGDIEEVGDDELGFAHDGEDGDEAMEGDCDEGEDEDGEDGEGSGNKKSKRQARREARKKRKGRDEEGLPVELLEAARQGGDEARKRVVDAMVDDYYALDYEDKVGDIATRFKYAKVEPTGYNLTAEEILLATDAELNQFMSLKKLAPYRRSDEEKVKASKQKKRLKELRDSIKARKWGDELPADGAEPPRKRKKHSQETGGSTSKEGGAPKKKRAGKSERKRKGKSAGTSEAGDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MV00</accession>
    <name>A0A2X0MV00_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g01959 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g01959</name>
        <name evidence="2" type="ORF">BQ5605_C003G01959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY38108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MV00"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY38108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="289" mass="32042" checksum="5AFE77BD341B620D" modified="2018-09-12" version="1">MSWKAAERRGVKPEAEGHVPGCFDGKWNLGERGRNGLSPREDGRIQEKLPERDKQYGALAHHYPHFGSLDGAVTAATPLEIGSLICFGLKCGMHSLSCDQTVYGEEALSIGIVTTNHSNQDTLASLVLLSNVVVQELRLIKKTCYSTHLIDGTMPFRMIDGRQVIESSGPSMTTYRSTTDLTSCYPDERLISTSAHAEQRFAALRACPACEMPPAEPLQAAQMPPRKQGAQRQQKGSLTTKQRASQQSKEGLFEAWSHAQHQPKRRAPQATSDRPPRARKRSERVFEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MYN2</accession>
    <name>A0A2X0MYN2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00714 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00714</name>
        <name evidence="2" type="ORF">BQ5605_C001G00714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY48922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MYN2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY48922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="133" mass="14400" checksum="D66947DA8736F009" modified="2018-09-12" version="1">MASTPSSPASSYLGQDSNPGYRASSPSSSTTSLSSASLKLTSPPPPRSSASTSPYASLPFQYIPLNLSRIKTPERIDERRSRYAELDSLPTSIAMNADIDSPGFRLTPEAIQARREAEIARAMDWLSSHPDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N198</accession>
    <name>A0A2X0N198_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C007g04471 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C007g04471</name>
        <name evidence="2" type="ORF">BQ5605_C007G04471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY60714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N198"/>
    <dbReference type="STRING" id="796604.A0A2X0N198"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY60714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="395" mass="43574" checksum="12D01B588096DCDA" modified="2018-09-12" version="1">MSGINNPFAPTPASVVQSTANRFPDISNDPAFQPQQQQQSQYGQQQQGYYPQQQQAPQQQQQLGYLQTQQTGYVSQPPSGGAYPTSSMPASPFGGASSQGAYNNQAQAQYGGYPSQQQQPQQQQQYSSAPPVSFSVSDLDPYSHLGTLHQSQLSQPPSSYSSQQQQQGGMMGQDGSQALPSHLVNVQQVQTHPRQYVQENKAIWAQLLARFDWCRLCLQTLREAWEARKSAVKQVALQGADPSAVERLTKDADTNIDSIHASKFQLAEVKDTWRHSADAASQVLPRKARVREALNAGLNSLPEYPAPLSPEQVGGAFYRRAAEEYRKQNIMSGYQQPQMTGHPQQQMQPQQYGIQAQPTGYYPPQQQQQQGGYLQTQQTGFYGGGGGGGYQQGYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N5P2</accession>
    <name>A0A2X0N5P2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C008g04967 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C008g04967</name>
        <name evidence="2" type="ORF">BQ5605_C008G04967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY78833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N5P2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="315"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY78833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="613" mass="66083" checksum="580650C2D6694FE3" modified="2018-09-12" version="1">MVNDEDTDYETLPAGPSQHRNPTTKTYSKKARQRATRSAPAAVEVKVPTVVPGSNEGGATTSSEEMDTALTSKGKRVKGNRRQRIASDGGQRRREGHAEMNAVRATEKAREREPMEQEMQNAKTVTSTQAHKSTEEAETAKAPLRGADPIWPSTAGTRDTRVPRTERLIEAKIPSQFSSTVPSKEHSTSSTSTSNRVGLPDPFVDSARTVMRPRSKKASALSDKSNLPKRSRVTSSKLKESTETLSLESMSLHGGEKPSEAEVIRSNAPGKTGSHSKLTKPTKKVPTQSTMGIFHDPSPAEANAKNDKKPHARASRTSSKSKAQAYAATVVPVSSVETPSLSSAGRAHSVHHSLGSQNSGYGQLPPPNVPFAAGATESSHSYHPSEEDLSRHSSIVIETYEMAEREASESDEEGDETIQAAINPLIANPTVSGQEVLDLVESEEVVLAPGEVDVHPTGWGSSPEEASTSTGIQMPDAHTTMAEPVLATKGPEQLPESEFLSPGRALPPRHRQLPLAQPRPGGPGSDEDDLAYYLAITATSSSGDEEQQDARDREEWLKGEAEVGKGAEPGWTMEQAQARRRRYILKKLPGPQGEEDSDDELNLRGEVSTRDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N6A5</accession>
    <name>A0A2X0N6A5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Galactokinase</fullName>
            <ecNumber evidence="3">2.7.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Galactose kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">BQ5605_C008g05167</name>
        <name evidence="15" type="ORF">BQ5605_C008G05167</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>alpha-D-galactose + ATP = alpha-D-galactose 1-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13553"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28061"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13554"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.6" evidence="3"/>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N6A5"/>
    <dbReference type="STRING" id="796604.A0A2X0N6A5"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019741">
        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00131">
        <property type="entry name" value="gal_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF7">
        <property type="entry name" value="GALACTOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457">
        <property type="entry name" value="MEVALONATE KINASE/GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Galactokinase N-terminal" evidence="14">
        <location>
            <begin position="45"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="12">
        <location>
            <begin position="177"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="13">
        <location>
            <begin position="483"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="337"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="350"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SGY79574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="585" mass="62989" checksum="222F66D9F1650840" modified="2018-09-12" version="1">MSGNSEAQQPADSSASIPVSSSLEHVYTPSSLPQQQQRWAQLQQLFEKQYGVKAQAVARAPGRVNIIGEHIDYCGFSVLPAAVERDVLIALSTSPKDTSNYPQPSQPDHTVIILRNVDDKFSPTHFEVDLNSSAWDVQMPKQHHWSSYFIAGTKGVLGHLYSRTAYLPSTGPYPSHVVMLVTGSVPEGSGLSSSSAFTIASSIAILHVVGRISGSDAIDRKAMTEVAIASERLVGVNSGGMDQAASVFSQPLHLLHIDFVPSLHAALVPLPRTKPGFAFVIANSLVTSNKAVTAKYCYNLRVAETRVGALLLAKHLGFAPTPGITFKTILDQYCSSPPYQPGPKSRKNKSSPLARQSVSPNGPTMAAKPTSPLPPDNANCIYEIKTMLGLAIDALGGPGMEAGMTWDEIAEKLGRDVDELEKEVACGQQVEPVGGRLKVWKRARHVLEEAKRVYEFVEILSESSTDDISKEASGSTKTGTQLLQEMGDLMNESMRSCQEDYECSCPGLDELVDLARKNGAIGSRLTGAGWGGATVSLVEEDKVAGFIKALKEGYYRKNFPKLDEQELDQVIFATKAEAGAGVVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-11-27" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NDA2</accession>
    <name>A0A2X0NDA2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C142g13435 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C142g13435</name>
        <name evidence="3" type="ORF">BQ5605_C142G13435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000141">
        <property type="protein sequence ID" value="SGZ35664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NDA2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="2">
        <location>
            <begin position="307"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ35664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="393" mass="42767" checksum="41A333A0C8ADF0D8" modified="2018-09-12" version="1">MDDTSPPLATGHHPPAFPKHARLDGPKTFANWTRQLRLCLADDIRSYILDGIVPVDWTPSQRSARDVVARELLANSIDSAEVSAVLDAIPTADLTAPKIYLTLKSWYAPDDATRTLELFSRLWSFRPMPGTVGEFDGWIMEFKAIAQEIIDTKTTINDVLATLLLAIAHPSLESFKASFTDEQRTQRSLPAIDSLADRMRVQLRSTNVPSTQSALLASSSSRPTRPKCLACHSPSHRVAECPVRAKHPPPGPCRSCKQNHWSFDCKKALENGKKADTANSTANSQHHVGCIATGFLARRRQLRTNSFVVDSGATSHMVSDKSLFTTYRHIAPTKIGGIAGGINAIGTGNIAFVAASGHPITLTGVLHTPGLFVNLLSVSRLCDTDDVRVAFTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NHV1</accession>
    <name>A0A2X0NHV1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C033g11131 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">BQ5605_C044g12178 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C044g12178</name>
        <name evidence="4" type="synonym">BQ5605_C033g11131</name>
        <name evidence="4" type="ORF">BQ5605_C033G11131</name>
        <name evidence="5" type="ORF">BQ5605_C044G12178</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ACBP family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000066">
        <property type="protein sequence ID" value="SGZ01176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000114">
        <property type="protein sequence ID" value="SGZ31449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NHV1"/>
    <dbReference type="STRING" id="796604.A0A2X0NHV1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF62">
        <property type="entry name" value="ACYL-COA BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="3">
        <location>
            <begin position="4"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ01176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGZ31449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="241" mass="26416" checksum="362E7F40F9398798" modified="2018-09-12" version="1">MRYTSAQFDKAVATVGQLPKDGPVKPSQPDQLVGLTLRRTLVWMDSGMPRACALVLVPNGCLPSAGDVLSSDKARVRTRLARNRIMKLDSTDFIGPLRWSGSLDTNVIAGSNSSYQFYGLYKQATVGDVNTSRPGMMDFVGKAKWDAWKNNEGLSSDDAKSKYVEAFLDILAKNDNEEGAKYKAEVSSSEKGSILRKAGVVNALDPMRYCDATMSCCTDYCRAGDRAHHRELTVTPQIEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NIX3</accession>
    <name>A0A2X0NIX3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C051g12525 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">BQ5605_C076g12941 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C076g12941</name>
        <name evidence="1" type="synonym">BQ5605_C051g12525</name>
        <name evidence="1" type="ORF">BQ5605_C051G12525</name>
        <name evidence="2" type="ORF">BQ5605_C076G12941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000096">
        <property type="protein sequence ID" value="SGZ29516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000127">
        <property type="protein sequence ID" value="SGZ34698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NIX3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ29516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ34698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="145" mass="16284" checksum="450ED2385FF587BB" modified="2018-09-12" version="1">MVRRCGWGPRPVGFSGQIGTHFGHVRLGKPKFADPQEQRERAQNIPGLRASLAFPATSRQRRLCHHRQYPTFSARLALTKRRGPDIDLFDDDFERMAPLLDVRVSELFASSFDKPANAPGFSLNSFHGRQTSLSSLNPLLGRSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NPF2</accession>
    <name>A0A2X0NPF2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BQ5605_C012g06756 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C012g06756</name>
        <name evidence="11" type="ORF">BQ5605_C012G06756</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0NPF2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="9">
        <location>
            <begin position="519"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="10">
        <location>
            <begin position="1005"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="201"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY16095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1429" mass="160181" checksum="5C05C64B51BBCCE2" modified="2018-09-12" version="1">MSKPHEDAPPRWKLHAPSYLCHTDRTLSGLRLFWSCNDRYFKKEKIETDVAKIDIIGQLLLDPELKYGVFQRNLTRRALPSDYMWQHYQRLDNLRQTGDYREFSTAARDLQLELGVSLVSDTQLVRMLLLHMDEELSQRLRLSEVIKGTGLSPDELDASIVKADSTTSSAVFDYQTFDAEARRLWQVISATRASVKATAQASARTVRSTPTLRTTASPSTLPPLSSKTRAPPMTDRERAFLRSNQGCFKCRKINAGHFKDTCTTWATSACKVPAGWRQGPVSPEQVASLSDAVDEIDDKGEELHCLCDDEYDNGTDDERCEPISLSVKLTTEDGPALRALVDTGASASFIADREVEKLRLTRRKLQVPTSHVVLKIAPLTSLKVVLGQPFLKRHDILVDCKRRRVLAPDPTLPGKRIDLMHRGEKGEWSESAVQASIRACLAHLEEQQAEESQLRALEVAFRKEFSDRFPADIPPVSQYESKVRHCIALKPGMKTPWQPTYGTPMRWRAAWRRLLDEHLVAGRLRPSSSEYSLPAFIIPKKGMDTDPSIMPRWVNNYRILNAATVPDRTPLPLPDEILAVAARARFWSKIDMTNSFFQTKMAEEDIPKTAVATPWGLFEWVVMPMGLLNAPAAHQRRVNEALSSLIGKSCFAYLDNITIFLDTMEDHQTHIKEVLEALRRADLYCSPKKTELFRTSCDFLGHVILRNGIAADQSKVEQIVGWLRLESNLVPFRWPRPRTVTELRGFLGLVQYLRKFINGLAQHTKPLADLMSKNANVRLMWGAEQERHFNAIKAIVTSLSCLKPIDHTDSADPLWVMTDASNVGIGAVLLQGQDWRKAHPVAYWSCQYISAEVNYPTHEQELLAVVDALRQWRVNLMGVHFHVLSDHELLKYLKTQENLSKRQARWVERLADYDFDITYIPGGENTVADAMSRYSFPQGEPDSVQAVSEMDVDTQLRGRLVEGYDSDPFCQQVKCNLDSSPGFSCVDGVLYFEATTTGALGVSHALAVPDGLMQEVALDFVGPLPKSQGFDMLLTITDRLSGYTRLIPSLAADTAKDIAERFHVGWHRFFGPPTRIVSDRDKLFTSHFWRAYHNLMGTRLAMSTSFHPETDGRSERTNKTAIQALRAVVNKQQNNWVRHLVNIEFAINASVNASTNKSSFEVVLGRSPSLLPTSLNRPDLPDVPAAKDLIAERKAVLAEVRDALAAAKVRQAEQVNRHRRPEPVIAVSRAPSFFSSLPIGLTPEARAISCLSGDFVMVDTRDRRLRFKTGHRKSAKLFDRFEGPYKVIAANVPTSNYTLQLSKGDRSHPTFHVSKLRPYRANDPNLFPNREPARPKPVIVDENEEWVVRDIGGDNKGGGEALSCLVGGLSAARSHHGTAWKLGGDRGASVLGVEEEDGGEGLVQEGEGARPEAFARGTMEGDRTFGLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NRQ4</accession>
    <name>A0A2X0NRQ4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C011g06388 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C011g06388</name>
        <name evidence="1" type="ORF">BQ5605_C011G06388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NRQ4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY12104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="62" mass="6811" checksum="30A29B406E08F257" modified="2018-09-12" version="1">MRKVDGIIPTWERELAVKGASWSRCRDSSSADVRCSIYDSAAAYQDSWPGAPAQDLSAHPDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NSE1</accession>
    <name>A0A2X0NSE1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C011g06249 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C011g06249</name>
        <name evidence="1" type="ORF">BQ5605_C011G06249</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY11722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NSE1"/>
    <dbReference type="STRING" id="796604.A0A2X0NSE1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY11722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="302" mass="33282" checksum="7B82E411BCE92FF6" modified="2018-09-12" version="1">MYQHSVVSAAPACGVGVPIRSHVQALWSPGTQGGPSQPRQVLGARVAPYHGLPWACSSARCWAPRGSTLLFVPLRSTESAPRRVMTTIQPILALRHVYEPAPHVSIRDDLGPQTAVCTHCKAQHWELGATVFRVFGRLYHRLGALIPAVNQSPAFAQTWLINPAEATDTRLEPDGADSHMQRSTLTKLESMLRTKNHFVREFASAKPRAGWDTAKDWVLRLCLPPGRDRRTHNPPTSSTEMAMLICDSDTNTGDRGPQDLILQVHGDRCPDGRPKYQIGKMASTPTFLFAGFHQARPPIARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NSH2</accession>
    <name>A0A2X0NSH2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C011g06638 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C011g06638</name>
        <name evidence="2" type="ORF">BQ5605_C011G06638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NSH2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY12875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="302" mass="32235" checksum="EA0C2771E523FEA1" modified="2018-09-12" version="1">MNMTIAELLAFDVAPADASLHIELSKDELTHYSTLSSTRGPTSSCPTQGRPMESSDPTRGEAGVGVSNTEEGRSTAHSCVLKGLVQSMGPSRCEDMAGTTRSFCWTGGDQMARALTTHEDPEQYGALAQRYPHFGLLDGGAVTTATTLEIGSLVCFGLKRGMHSLSCDQTAYGEEALSIGIGLVCYSAIHLQQSDNGALASLVKACSSINLIDGTMPFRMIDGRQVIESLGPPKITYSSTTDLTSLYPDERIISTSAHAEQRFASLRSVPGLRDAAGRTSTSRKCHGGYKKLKFSKPILTMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NTD3</accession>
    <name>A0A2X0NTD3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C010g06085 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C010g06085</name>
        <name evidence="2" type="ORF">BQ5605_C010G06085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NTD3"/>
    <dbReference type="STRING" id="796604.A0A2X0NTD3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013933">
        <property type="entry name" value="CRC_Rsc7/Swp82"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08624">
        <property type="entry name" value="CRC_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY14167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="396" mass="44072" checksum="DEB74713E641CFC7" modified="2018-09-12" version="1">MLDDDPRGDAKVDALGNLLGGRQYKTKAFTSSMRPNPKKLYMFSIDTARAAGFRDSLYFFRRHPTVHKITIGQAEKDKLIAEGKLSLSMKSRIVTMVTARNVFKVLGAEFIKNGKYVFDDYYEDKALAEGHQPGEQASNDPVEPTDAETAAASASASAAAPATTTTSTSTSTKRSAPRDEYISIAGGGTTFGGIGLQPFAKTWDPTAKKARPPAHLNMEIWMLEYAKAVRRRDVELSNIRRANVGQVHLNPSGLIGDREEDAWLEVEEDVPSDEETGEERMDAGPERRRRVRVYNPLRGIYEPETNIPHVWKQTQATRSQTVVVDEVPHLWENEAERQEPKRRRIESKAAKLGIATIETVVEEEGTLGRIGEDLLPGMWVFRTAELANVELSRATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NUI6</accession>
    <name>A0A2X0NUI6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C013g07357 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C013g07357</name>
        <name evidence="3" type="ORF">BQ5605_C013G07357</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NUI6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY15391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="327" mass="35863" checksum="862840178FB7525B" modified="2018-09-12" version="1">MSASGSSFPVPPPPDYGPSHPIHSNNPNPNATSSPLPSDPPPPPPPSSEPLTDAQLTAQLNASTLKFYKHTYLTFLSYYVPRLTLLSGGSFVLKLYLLPWLFVGIRWLGRWVLYAFEKLLFGLVWIASWGALYSIGIGILGGLLAGAAMWLWFEWPSLSSAYPRGSKLALYGTCSLVVGWIASSSFKIGIPLGIVVAGVCIRSRFATRNKFGARGFKKGSLNQGRNEDLDKVDEATQRRLQKLREVSEARRRNQQTTSTLNGATTTEEGEGEDDDLMDREAERWARKAREEMLREELTRRARGAGGVLSGTTTRSEDVEVGAGDALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NXB8</accession>
    <name>A0A2X0NXB8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenine DNA glycosylase</fullName>
            <ecNumber evidence="4">3.2.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BQ5605_C014g07530</name>
        <name evidence="16" type="ORF">BQ5605_C014G07530</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.</text>
            <dbReference type="EC" id="3.2.2.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.31" evidence="4"/>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY18991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NXB8"/>
    <dbReference type="STRING" id="796604.A0A2X0NXB8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035485">
        <property type="term" value="F:adenine/guanine mispair binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032357">
        <property type="term" value="F:oxidized purine DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000701">
        <property type="term" value="F:purine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000002">
        <property type="entry name" value="Adenine DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044298">
        <property type="entry name" value="MIG/MutY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944">
        <property type="entry name" value="ADENINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944:SF1">
        <property type="entry name" value="ADENINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="15">
        <location>
            <begin position="126"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="527"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="604"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="532"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="549"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="604"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="620"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="630"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="657"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SGY18991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="704" mass="78025" checksum="793236C27768B641" modified="2018-09-12" version="1">MVERRPSASTSSSHPISPLLPAILGSKTRAHPSSYHCFIDSPYAAASSSTSQSSQKVSKKGKQSASTPAPLRDAIPVRTLHQNLLTWFDTVREKRQMPWRKDLIIETMSTSEKTQRAYEVWVSEIMLQQTQVATVIPYFNRWLLAFPTVGDLAKADIEKVNEIWKGLGYYSRASRLLAGAKTVMRQFEGRIPATAEGLERIDGIGPYSAGAISSIAFGKRAAMVDGNVTRVLSRLTAFHGPSTAKATTTYIWALAATLVPPQTSQLPQDYEPLSVGGPNKSGSWNQALMELGATICTPKQPKCTECPLKGQCSAFAEVRYAQSQRLQQPKSPRREDVGDIEDLCQLCSPIENFSPRTHDVIQYPMAKERKKPREEETAVCILEWQPEDPEKEKEVLMCKRPEKGEGRARFVRMPAPFIRVLMLECLHLFLIGLLAGLFEFPSIDLSPSSEASTSTLRCKLLQRLLQTLIIDSLPFNASSSSTSTSPLTIKQNDPLPPAVQVYSHMIRTYHPIRIVITSAHRPRLVEVESKSKMTKKLPRRKKKGASCSSDDDDDEEEEDSKKTELMQSIPGRSKWIVASEVENANTGGASDKIWGMRMNVEKGLKALKGSEKGKGGGGKGKGKGKGKGTGKKEKEVVGEGSKREQGLMRNWLVKPTEGNKRRGATKEEEEEVVVVDEEIKVVESSPGKVYKKRRIVIDSDEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NYF5</accession>
    <name>A0A2X0NYF5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C017g08492 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C017g08492</name>
        <name evidence="2" type="ORF">BQ5605_C017G08492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY20148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NYF5"/>
    <dbReference type="STRING" id="796604.A0A2X0NYF5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY20148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="859" mass="93751" checksum="ACAABA2A06B03B91" modified="2018-09-12" version="1">MAVPNLSTPNSTSASTNACPAAADDSSASASASASTSPSTLSLFLRRTAPWPPPIPSTSTCDPVPVSSQHENTTPGTGTAKTTLTSNGKGKPTLRSRSGKSKSTRRPKTTLNSVPSRTEHTTGDQVHDHSADLHHGGGAAKEPYDPFSVHRTPPTKHHLVPSDPSIKTCQAIDRWQEQCTEVVVGGHKGKVNRDWCHVHEIEQAQVKHEFIRCIAALPAVSKQVPLPDASDITRCDDLDDLETWEKIARQHAALSDKALACRDYYAVHFAASGLDLASLMGRMSLEELALRSRAADGVIRLVTRRSHLLILTSEDALWLLEPQSHSPNPPTTLPNGEPAPPVPNCLSGTTPNSTSIPLRPPCAPSLQTEAEEPDPVVALERVKRAELLELLSLTGSHASFIKNSTKSVQRVRVIECLFRRLISRDEELLVKAYRSGHDHVLRFFEDVTCCSLAALTRLHAALKRTSSLSLKEAIMDAFRAIAWEESGAGETEPGEEGLGLQLLGGWSYKIQLSRSMSPVEWSHLYDLCGCPGCALRCCLRFSDWTYIRRLSIVSPSTNPTLSPPFEHWADSINETDAVKIFKAFSVVKCAESGPGASEPEIRRIAGGFVGAKGKGMWLERIERNWIMIKLGFGDTKADARQSLRLIDALQARHPLIIRIFPDGLFGGERYPTPPSNQLWYSRYRSASSKALLRHQPWSIDQNAFGKDNATALITFDTLDSPEKAQGMGSFKYTFEVVVLDGHGRDGPGSGRTANENQNRSFEQFEAELGQLFCEALGVEDVKGAIRYARERGIERGEFVDWGISSTQLAAMEQMGVGTNATNLTMVKKKAKGGGNGGNAALENLRDDALALKLSRNLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NZD0</accession>
    <name>A0A2X0NZD0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Large ribosomal subunit protein mL46</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C016g08101</name>
        <name evidence="11" type="ORF">BQ5605_C016G08101</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL46 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY20589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NZD0"/>
    <dbReference type="STRING" id="796604.A0A2X0NZD0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04661">
        <property type="entry name" value="NUDIX_MRP_L46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040008">
        <property type="entry name" value="Ribosomal_mL46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021757">
        <property type="entry name" value="Ribosomal_mL46_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033650">
        <property type="entry name" value="Ribosomal_mL46_NUDIX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L46, MITOCHONDRIAL PRECURSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11788">
        <property type="entry name" value="MRP-L46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="10">
        <location>
            <begin position="136"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="28"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY20589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="314" mass="34511" checksum="EF9A0D923B8D364B" modified="2018-09-12" version="1">MSRPAASRTLHQITCSCIRPVQLQTRLASTSSKTSSASETSTSDSTGTASTSSSASTPSSSSSSTSSSSSSSPRIVAAALISRPPLLLPSLTAFERTYYAYQRRIARALAKPVSVSTSWFFKPNSTTEKSFSAYDQATTAVDTGLENPMRDFELAGEQVEGAAELVQRQTEADEKGDLKSLERKGDRTLYMLLKKDRNTHAWQFPQGGVEGDESLLEAAQRELIEETGPNMDVWPIGKVPAGAYSYPFPKEHLEKKPEHTEARVFFLPMRIVRGQAVPNKKEGLVDFAWLTKEEIREKVSQGYWEAVEPMLSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NZD8</accession>
    <name>A0A2X0NZD8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C019g08862 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C019g08862</name>
        <name evidence="2" type="ORF">BQ5605_C019G08862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY22828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NZD8"/>
    <dbReference type="STRING" id="796604.A0A2X0NZD8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY22828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="410" mass="42707" checksum="B50DA025502307A2" modified="2018-09-12" version="1">MPHDLHHNRRFLIHRRALPVLSDGAVVQGATPAVELTAPTFAADSGIVVASASGVDASSAVVGAADSVASTTFLTTTTTTTAPASPSATDGSFAISIIQDEPSVTSASTTTTTAAAASVFSAGPALISVSQDAPTGLSTVARDGLIVAIGLMLMAWVIYRGCRRRRARAALTASITSDSSSSLDGMSEKSRKVLFLSPPSQAKTTRDFKSSFDNYTATSPGLTTPAGWATFSNTSIPETMHTGVSTIPPLPQPQPSRWSASTYGDSRIPIRPTTPSAAPLSPTLSTPSTPPMGIPITIDPFDDRHIPPTPSTPSPSARGHSIKRKSPPMLPEIRVSVSDSESEEGDMGFTGTGFRPDYAMGTAAPVKAAEETLESPKSGSKIMRGTQTVLRVHNKGDVLDDEYGSPRCRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NZS4</accession>
    <name>A0A2X0NZS4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="7">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C001g00271</name>
        <name evidence="11" type="ORF">BQ5605_C001G00271</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="7"/>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY45300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NZS4"/>
    <dbReference type="STRING" id="796604.A0A2X0NZS4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="192"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="401"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="48"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="650"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="653"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY45300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="718" mass="75465" checksum="5FE6596C29570223" modified="2018-09-12" version="1">MTSQLLSSSRKLKFQDLRRRVFRFQFDSFATTSLGRVIRGACTPASSIDPIHSFHPAMSQPRNPPPTNDGRPHKRRRPQKKTTSSAPKLASASGPATPSTAGGPGLSLLSRLSTVAASAGPGTGTSTPALSSQAPTPTGTMTPVAGDSSKAFTQLKFEDLYHQGKISQRTAQGIAALSPPHIYCTPVQEATLPVILTGVDVLAQAKTGTGKTLAFLIPSIELLLRSNPQPKADGISILIMSPTRELAIQIEEAARILLSSTPFGVQHVVGGTNMKSETTRLNNQRCDILVATPGRMLDHLENSNLKLKLSECRALIFDEADRLLEQGFRREIEKILQFLPRRDVQPRQTLLFSATIPAQVHQIASLALLPTHRFVTTLTEEDQNTHEHVPQFSVVADLHDSFAATLVAIRAEIATHGPATKIMAFFPTARATGLAAALFTRLNLGLPVLEIHSRKSQSQRNAAAEAYKAAPSAILFSSDVTARGMDFPGVTTVLQVGLPSAPEQYIHRLGRTARAGASGSGVLILSPFETFFLNKREIKALPIQDHPLASTELKPDSAAFRTAKTQVAAAMRTIDDDLKSQFYGATLGFYKTYLKDSFRGSAENMVATFNAFATAQDGLAFDGASGAVPGISAKTIGKMGLKGTKGLNVLPGDGKGGQGGRNSGFNGGGVGGGSGNGAEGGFSGDRGGGSGGRGGSRGGGGGGGRGRGGGRGGMRGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P115</accession>
    <name>A0A2X0P115_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00911 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00911</name>
        <name evidence="2" type="ORF">BQ5605_C001G00911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY50652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P115"/>
    <dbReference type="STRING" id="796604.A0A2X0P115"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="575"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="590"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY50652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="764" mass="85711" checksum="334617689DCA9969" modified="2018-09-12" version="1">MDILPHTPPPLQPSSASPVGTEKGKRTDKTKRKKSTTVRRRRKKVTSSNKDTFENGATTSVGTEEEAKTKKMKRRKLWTKRVRKREPSLSPDSELFDKAFGFNFGIFRSPTKRRPKRQPGPPLSPSVQRSTRRRKEHSEKSIAGLHKSSSEAWTDIADGATAWPLDTETGGFEHNFKPNSAPDFEPDYDFGRDFGGGYSSGPEHSPFHPDGASQDQAPSSLKRSQIERNAKKQRNRRRNARAEAKTRASKRAELLQAYLLMKKKAKEVLRQSGFVPSPDDEGWCDACHERRVTRKVRVVDLFFAGMRELRYCPCYPEIQTLAAHGLLPTSSSSIRKREGITAFTFRTIEYLNTYWGVDPFGIYDMSEALILFWSSELSSEDPFNKGPTVRQHLQAAMDEYRFMQQLQATLTAEFIGLSPRERLADVCPACFGPRIDEAGKSENDLDVIIAVDGNFQHRRFVRATADPLKSRPALFLSPDKIRNEQALIDGSTEAGEQVPWCCWCRDECTTNWKAADGGVTSASSNVVADTGLVAAVCRHDHCLRLCNLHQSGEKLVYPVSLLKWILEEVEVGETDCTTGPARTSDATNVGSSSGSGSHQSSRQDRSRVGVAYDIACNLSSHLRRLISPRYAQRNLLADHLPRLEFALSSMHAYAHKWSCQVDFDPRFLPSFGLTDAEGAERLWSQLRGMIPMNRSSSASHRLENINRRASAYNKQHLAELGSPKLTKLNSRLKNAIKLKAEADRVIAEVVNRSAEWTVATLLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P203</accession>
    <name>A0A2X0P203_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g04167 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g04167</name>
        <name evidence="2" type="ORF">BQ5605_C006G04167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY56755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P203"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY56755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="305" mass="33520" checksum="E2F0DF3F886FCA81" modified="2018-09-12" version="1">MNMTIAELLAFDVAPADASLHIELSKDELTHYSTLSSTRGPHTIETSASSCRCSRYQFLAELANLIQLPIKVLISVATSSCSTQGRPMEASDPTRGEAGVGVSNTEEGRSTAHSCVLKGLVQSMGPSRCEDMAGTTRSFCWIGGDQMARALTTHEDPEEYKQYGALAQRYPHFGSLDGAVTAATPLEIGSLICFGLKCGMHSLSCDQTVYGEEALSIGIGTRQSDTKPLQPRHARLVGSTLKYRRAQFQQKGSLRTKQRASHQSKEGLFEAWSHAQHQPKRRAPQAIFDWPPRARKRSERVFEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-10-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P2Z7</accession>
    <name>A0A2X0P2Z7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g01901 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g01901</name>
        <name evidence="2" type="ORF">BQ5605_C003G01901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EFR3 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY37853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P2Z7"/>
    <dbReference type="STRING" id="796604.A0A2X0P2Z7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039786">
        <property type="entry name" value="EFR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049150">
        <property type="entry name" value="EFR3_HEAT-like_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766:SF1">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21072">
        <property type="entry name" value="EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY37853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="920" mass="97647" checksum="34A3F18FDF8E0EB4" modified="2018-09-12" version="1">MPPFFKSNHLKLIDACYAVDLGSGTTTELPGAVSNSLGKLTFYASGRPKKIPKVTSVLLERAEKIARAAQSGGVNSKARGGLAVTLDVMRAIVVECRDELSCFVAHALRCVELGLTRNKMQQRDVPLEAKAASLFIAVSIYSTAPFQSLNDEAGKLYLRCVALISSLAQLTGDQTSGSRLVALQAIKGTVTSELLYSASSDYDSLVEEIAPALLQNIIDLPSDQFTKHISADDDPDSAFSTVNVGPLADRKVREIEPFNEPSSDQVGKEALDILRSLAHLSHGAQLSSMLTAMGNYLDRARGGALWKERTLVTWLGKTIIAACPVQYRATVVGWWLDMIVEIDDTDATPKSEALLYTLAQILRGPTSLVGLGIGGVLNQLTSLVVKRCPWGDKDPLTKPLLATISSLASSHVYYVDQVNDIVSDLIETIRSVRDGAGVAARLNERERFRALRQLSGALKQVLLEAAKSSDSIKIAVPVIANGVNGHDARSRTFSTTGQKDDFGRPKMRVAEAGKRNRISPEVFMGSLFLLTQNDAIARTDYERALLLYVANELAIPEDEEDVATDSTSSFAKFCRALFTSIQELALSPILRPAVNNYGRALSRRTSGAASVRSGRSRRQRTSSAAADSLSSVASAADYAALVEILRSFIARRSATAVVNVVPMLIALQKSAARWGSTADTDGQVVPQTDERTQACRELVAQTFHTIGEVWGATETQRLAAQAVHALSPSVLPRLGASTSGEFAARASRASSQIDLAGVIDGLASSLNLQQAAGQGLGNALVLPWQPEILVDVLLNIGRSLGSGPYGHGNRSVTNLSNVGLNRGGSMAERRSLRAPSLVDLQSSLGSRAASARGSAAASIASTNAYSLANSANAPGTGTCAPSGRRTSKAKASAVLDRLSVSAAKKTSVVLPQALRGNGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P315</accession>
    <name>A0A2X0P315_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sorting nexin-4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Autophagy-related protein 24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C003g01921</name>
        <name evidence="14" type="ORF">BQ5605_C003G01921</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY37934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P315"/>
    <dbReference type="STRING" id="796604.A0A2X0P315"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06863">
        <property type="entry name" value="PX_Atg24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000042">
        <property type="entry name" value="Vacuolar targeting protein Atg24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949:SF2">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="13">
        <location>
            <begin position="151"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="30"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGY37934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="546" mass="60928" checksum="1C33E3030A10C3D5" modified="2018-09-12" version="1">MGQTLPDSATGSAEARSALGSFTRFHSPYIDLAHHSSPAPQAARDRPPPSCTPPDTNTSEDRSFRCTASDRPSQHRHRPMQADDDFGSVAWDRGTTTTTSASTQDALPNSHQHDGQSTEPSSSSYHSPDSVIAQSTQHEQHVAATTSSHVVHSCCVSEGKVELKDTKEAFVSYLVSAKTELPSFTSKSPSARRRYTDFVFMRDLLTKDYPAAIVPPLPEKHRMEYVVGDRFSPEFIERRRVDLQRFVERLSRHPKLSQTDTFRAFLESSEWNVFKHKQLARHSTDAEPLGGLLDTVSDTLLNAFVKVKKPDERFIEMRHQIEQFGEGLVSIERLSARNRTRLNDLTGDYEDLAMGVQGLGYLESGMTDVLMRFERALVDFGTSVREYGEKSSEPFLEHVHSLLAYSSSFKGVLKLRDQKQLDFEELSQYLSNVVSERDRLAGGFGYGMGIGSYLKDKVDSLRGAADDTTREAKLAKLDTKVKALQEAVLNSQDTSQAFNEEVIREAAIFRSIKRAEMKELLGAFADGQIAMCKATASAWDKTIPQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P3J3</accession>
    <name>A0A2X0P3J3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C007g04788 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C007g04788</name>
        <name evidence="3" type="ORF">BQ5605_C007G04788</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY63271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P3J3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015975110" evidence="2">
        <location>
            <begin position="21"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY63271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="258" mass="25737" checksum="56479471BA9E1B7A" modified="2018-09-12" version="1">MRPASIVFALGAFAPTSILGAPRPQGQSFAQAGSLLKRLADGARLQPRQDISGGIGMFSLTELPALTELAQDVARSASTGKCRSECRGWTEALTVCTDTNSDTEAIGRCGCTSSTLSEMSPCARCFDSAEGYTSFENLCEYLNTGTVPSSLAAASSISSASSATVSASATPASQTADEATSSAATSSVATTPTSSVATTPTEPILTSALTTTAGTDPAVTSAAGAATSSRAASSANGRVDLVAGSVIGSFAFLFALLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P3Q6</accession>
    <name>A0A2X0P3Q6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C003g02181 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C003g02181</name>
        <name evidence="7" type="ORF">BQ5605_C003G02181</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P3Q6"/>
    <dbReference type="STRING" id="796604.A0A2X0P3Q6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000153">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="8"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY39240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="362" mass="40497" checksum="B3B013AC17CE5756" modified="2018-09-12" version="1">MATVPCQYKTGRTLGQGTYAVVKEAVHIKTGQYYACKVINKRLMEGREHMIRNEIAVLKTISQGHKNIVTLWDYFETQNNLYLVTDLCQGGELFDRICAKQYFHEHDAAKLVQTVVSAVAYLHGHGIVHRDLKPENLLFRTKDDDSDLLIADFGLSKIVDEGTFSALTTTCGTPGYMAPEIFKKQGHGKPVDLWAVGVITYFLLCGYTPFDRDSQVDEIQAICAADYAFEPAEYWEGVSQTAREFIGKCLTIDQAKRITAVDALAHPWLQISDAAPAPDADQQQNHDLLPTLRRQFDPAKTFRKAIFTVRAAAALQDGGRRQRQMTMRGAQTEEQKAFAASVEKMREDAETESSNVIEVLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P4P6</accession>
    <name>A0A2X0P4P6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C001g00025 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00028 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">BQ5605_C001g00031 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C001g00025</name>
        <name evidence="2" type="synonym">BQ5605_C001g00028</name>
        <name evidence="3" type="synonym">BQ5605_C001g00031</name>
        <name evidence="1" type="ORF">BQ5605_C001G00025</name>
        <name evidence="2" type="ORF">BQ5605_C001G00028</name>
        <name evidence="3" type="ORF">BQ5605_C001G00031</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY43465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY43500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY43536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P4P6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY43465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY43500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY43536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="65" mass="7624" checksum="0F2FF5C32DA50B96" modified="2018-09-12" version="1">MLEKAGLLHRPCRHPHPGALPPKCEVRSHLKFRLRRLPDGELLEFWTRRCELTFSLELLAHGMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P763</accession>
    <name>A0A2X0P763_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C005g03713 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C005g03713</name>
        <name evidence="3" type="ORF">BQ5605_C005G03713</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P763"/>
    <dbReference type="STRING" id="796604.A0A2X0P763"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase zinc-binding" evidence="2">
        <location>
            <begin position="36"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY77740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="150" mass="16565" checksum="2B938948B83AAADD" modified="2018-09-12" version="1">MRPARSARLNSTPGYSYKDGIARFEGRIFLPKTGDFRKNAIHDAHDATGHFGLHKTYEQLRRDFIWSGMKELCKEYVESCSVCQTMKMHGTGFAGRIHNLNLRNRKGARTGIGPAAGEITRALRQLRAFKSPPQGGGLAGARPSPLAPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PB49</accession>
    <name>A0A2X0PB49_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C034g11322 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C034g11322</name>
        <name evidence="4" type="ORF">BQ5605_C034G11322</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000065">
        <property type="protein sequence ID" value="SGZ00045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PB49"/>
    <dbReference type="STRING" id="796604.A0A2X0PB49"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="3">
        <location>
            <begin position="90"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="137"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="274"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="335"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="487"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="536"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="673"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="806"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="996"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="949"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="382"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="503"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="536"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="563"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="593"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="607"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="679"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="809"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="996"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1008"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1034"/>
            <end position="1048"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ00045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1095" mass="117775" checksum="3367D49562D534DA" modified="2018-09-12" version="1">MSSSSPEDQDDSLRVHPATQAIASGATLIDPTPSDEAEPELHAGASATAPSTLTEQVVVDDEDNEENEDTEDDEDNEEEDEDVTPSQKLWPVKAIIGERRGQYLLAWDGTDEHGRSYEPTWEAKSNATLGLIKHWEATKAPQATNKHARATCPSMNKKGKQRMSSEPVIEIEQRQRTREKSSSVEARATGRPVKKGRKVAFQIRPDSDSSESNESDNDDTRGAGSSDGCDRDVVIIEETMPVIVDSQGDEIFLPSSLLPPPYLPDRKPLAELSVSSSSTQSIRASSSSSSNNHSLRSSISVVGSTPTASAVSARPMRPVPIPTATDFYPLSQVEIDPIENPDSSPVRPSMSRLPATRPSTSVPLRRTGSKPQLELVLQTPASSGSSSSSNRTCSDENSSLSLPMMPNVLAHAVVGPFSVQVAAQAIIAPNKINMMRPPPTFLSEDGDGDMGFLNARVAVRRTLECLHPLASPAHPFTSSFSTRSSFGNYAAADGSEGEPSAPQPYQQPVQNTAPIHGLSAPESYVASTNDSNGSIGSSIIPSSTNGASSLRNASSSVPAGSAAPPPPPAPNTTPAPTPNPTKRDFPESNEEEQQSKKAKMVEFADNPLTSIETPPSTTTESERNHVESTGGSLARIMDASTRITLPPHMTPFTVPTQPLSPALARVQAVEGLAAESNDRQGSPGPSGTGQTAAVSRNASPAPGGGSHVDGLIQLVHASTYITDTDSTKAEIERFLRDPKAYASNPEGPLCRVAHWAFELRHVTQENIEKIDFIIVHSQVGTYQLKRVAAAHAQFDFARSLAHASTRTRGLTPGTPAAVPAPSAAVEPAAPLPKPIEMMSRDELERELGELRAQTSTMSAELETLPPLALEVTKLRTEIATLLKQNCSLAASKESAQSDFAYMQAQYSQASTAAVMRARETVVAEAETLRLRSVLDRGLKQNAMLFKAENKKLKFMVKRLEGEMALLKAERRRVAESEVIKKAALWDDFQAELKHHEEIENDLERNDSSDEEDERDDDEESAPPQEESAHVAPADTTTSEEVNLSSSIGETVPLPPLVCQWKSSGEDGRVCDATLQTREELEQHMATHQTTQSYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PC90</accession>
    <name>A0A2X0PC90_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C005g03197 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C005g03197</name>
        <name evidence="2" type="ORF">BQ5605_C005G03197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY72688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PC90"/>
    <dbReference type="STRING" id="796604.A0A2X0PC90"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY72688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="452" mass="49011" checksum="20302DF3587D0046" modified="2018-09-12" version="1">MFGEEPCESPRLASPWRNLSSSASSLSHSPLSLSSRSTSAPGTPNDRALERSPPHIRRSDSIETLLSNGLEEDFDGLSLGHGLIMQARKELPDGVRTIGPESDKTGHIEYKFVLKTPTTPHRLARLVTQLKWRLIEGGGCAVYELGVLDAGTLVGLSRVDMQETLDTLGLMLSHLGRGHVRISRVVLLGGAGGGSEISSTTPPHEADTTPSSSTLGFTSFDVGSTAIQPVYPGTSPITIKQPNPPNPEREPEERAALKRNKRDARRVKQRDYGGDIVATGHPRPNMESMESSTFNKARATRQYEAGAVRQPRNFRPSTGQVPGSTPEETYAPTRRPPNSTKQQAPTRPKVILTESIPSHRPRILSEDENEERFVVEAVVMKRPSSAMTPCKGESSDEGLEGMLARTPNDGSSLDAGPGSDEMFGSVDDEEGWSYLAFDSLPKVRRESSSVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PD42</accession>
    <name>A0A2X0PD42_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C005g03658 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C005g03658</name>
        <name evidence="2" type="ORF">BQ5605_C005G03658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PD42"/>
    <dbReference type="STRING" id="796604.A0A2X0PD42"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1200">
        <property type="entry name" value="NADH-ubiquinone/plastoquinone oxidoreductase chain 6, subunit NuoJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001457">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042106">
        <property type="entry name" value="Nuo/plastoQ_OxRdtase_6_NuoJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33269">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33269:SF17">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00499">
        <property type="entry name" value="Oxidored_q3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY77520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="180" mass="19447" checksum="A22A96C199363EBE" modified="2018-09-12" version="1">MNNFLIDLLALGAILSGIMVITAKNPVISVLFLIAVFINVAGYLVLLGVAYLGLVYLIVYVGAIAILFLFVIMMLNLRLVELVDTGQEYTKSLPMSAFLVSLFFFEILSILPASYHEGGSGGKYLFNVLNKSLLGLSSDTDLLNSEGVNNAFNPNIADSTLTTFTQIESIGQGLYTYASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PEV1</accession>
    <name>A0A2X0PEV1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C008g05318 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C008g05318</name>
        <name evidence="2" type="ORF">BQ5605_C008G05318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY80167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PEV1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY80167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="121" mass="11677" checksum="37E1F017F8766837" modified="2018-09-12" version="1">MSDPAAQDAAATLSQVANSGGPIASTSTTSAAAAAGSTSSSAVLAAAALMAGSNPSASTSNNTSQDAETSDVAILDPTLTAVASPNAQMPANYNKDLPMCANCLTQTPSTEFGSGKSFGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PEZ2</accession>
    <name>A0A2X0PEZ2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">BQ5605_C009g05580 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">BQ5605_C009g05580</name>
        <name evidence="18" type="ORF">BQ5605_C009G05580</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY82585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PEZ2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0229">DNA integration</keyword>
    <keyword evidence="14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="17">
        <location>
            <begin position="229"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="GAG-pre-integrase" evidence="16">
        <location>
            <begin position="337"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="159"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF13976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="SGY82585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="595" mass="66631" checksum="4A1EA5B160D2773D" modified="2018-09-12" version="1">MVKSKSLSAKNIWEKLKQHHEGNADPSKIRTLLYEISNASYDEDTNLGEFLQGITDKVDQLEDLGQKFKDEAIVAFMLQALPPSYEMLKQAIKLSDKCSVDYAVNRLTDEYSERKLTGKYDKLLKNAGALAVREGTQVKRDPNCICRGCKGTGHYQIDPECPKYDPNAKRGRNKNHSNKKKKQHKHSKGSADSEESASFALVVKSLEESHSLHINVANRVSQNDQSEIWILDTGASQHYVGNASLLTDRQHGSLNVQTASGQVVHCDTYGTVRFKLRSGASLSLSNVYHLPGAPVNLVSTRALYRSGASCGWEDGRDVMTIKIKGLTVAKTLNGTGYTLDFTRIVEDQAHVATRATVGAPLMEWHRRYGHIAVSSLKELVKSGAVDGLVLTDEKVHDCEPCISSKFRVSKFSESVTHVTDVLQRVFMDIGFVAEDQVDFQGRKAYLAIVDQYSTAKWTFPLKTKSAEEVTRVWIAFRQGVEKMTGRKIKRVRDERGVLHRIRPVLPGQLGGCKDRTNDRHQRAIEAFDRSILFLLVNSLPLSVRTRLILRPVIFSTPCRNAIHTRVTSSADLVFNGNVHLAVEYWSTIARYAFRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PFZ1</accession>
    <name>A0A2X0PFZ1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C025g10067 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C025g10067</name>
        <name evidence="1" type="ORF">BQ5605_C025G10067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000087">
        <property type="protein sequence ID" value="SGZ27153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PFZ1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ27153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="172" mass="19858" checksum="80532122BCCFCEA2" modified="2018-09-12" version="1">MTFIAFSKAYMLKGRKNFVEWDSFLNMFLPDDVYNYLTGGRDKVKWTDAYYARGQEYASRVLIASIDPICSSDIIPIRQMKGTAHECWLELASRYRPSDAQAAATLVGDFWNLPPIPTTEFGFNQWAGHVRIIVNSMRNLNIDFERNMLRNIVAVIWTRAFLERGVCERSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PG62</accession>
    <name>A0A2X0PG62_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C009g05809 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C009g05809</name>
        <name evidence="1" type="ORF">BQ5605_C009G05809</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY86282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PG62"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY86282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="571" mass="63807" checksum="043F0405A4DC8BC6" modified="2018-09-12" version="1">MYQHTVVSAAPACGVHVPIRSHVQALWSPGTQGGPSQPRQVLGARVAPYHGLPLATMGLLERPLLGAPRLDPPLRPAPINRISPRRVMTTIQPILALRHVYEPAPHVSIRDDLGPQTAVCTHCKAWHWECERSKSTRHFSACCSQGKVRLPPPPQPNLEYRQLLQGSDSEAKAFRENARSYNNALSFTSLAAHWDQTQVGTLGPPLFHVFGRLYHRLGALIPAVNQCPAFAQTWLINPAEATDTRLEPDGADSHMQRSTLTKLESMLRTKNHFVREFASAKPRAGWDTAKEWILRLCLRPGRDQRTHNLPTSSTEMAMLICDSDTNTGDRGRQDLILQVHGDRCPEGRPKYLPLARSIRPRCLSVTHYFFLQGKMASTPTFLFAGSTKPGRQLPETESRSTMVSNCASYLPVSVWMTKRMVMVNVRVFGSLSDDEGQVKGSRSRWRVSRSTFFTTCQRRRVLLNPALHPTSLPGVCDLRIEPTPHRDPRHQRLDPEPNRDITQRYQDAMACVVNHGKPPLLITMTYDSDSPETKAALGPIQHATVRISLHECLKPSPATSDMQAVSAMNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-11-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PJ61</accession>
    <name>A0A2X0PJ61_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C103g13162 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C103g13162</name>
        <name evidence="2" type="ORF">BQ5605_C103G13162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000072">
        <property type="protein sequence ID" value="SGZ10558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PJ61"/>
    <dbReference type="STRING" id="796604.A0A2X0PJ61"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="43"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ10558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="150" mass="16411" checksum="084B4885FD2DCE43" modified="2018-09-12" version="1">MVIIFHSRQPYLLAHVSAAAKESYRSLPSTPSLNLDSDASAEHKGHSDAIWCTKWARLENGESLVITAGADHEIRTWNSSNGAKPTTVIKPKQSLGIVGLDVERDSSRGRSSSYFITNTLDSVLTRWTLEGEQQARKELGPGQCSSELNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PMB3</accession>
    <name>A0A2X0PMB3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C024g09930 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C024g09930</name>
        <name evidence="2" type="ORF">BQ5605_C024G09930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ26514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PMB3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF5">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE CMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ26514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="622" mass="70044" checksum="F7D166D2E7CF1EF5" modified="2018-09-12" version="1">MPGLEKDEEQGHGLHDAGVDPELGMIPGPIPTSTTTTASTTPPPSNKRPFGWGVSSRPASGATSLLPQTRSPTRASFPGSRLSWLDGAGKKSFKARFLFVCTAAWVLWQLVVGIPDSASRRARTRAITKRALIGFESIERRRQVLPKDIAGERTWWPIEDLLEHSLLAKHPSPNCNLNIYQKDRYAPLLSRYRYRGPHFYHNNTDWTVVPHYLPRKKNTYFIAINLINSDYVLPALIRVFYTVLSALGPSRFHVSIYENGSTDTTPAQLYLFAMVLDRLGAGYTLHSDAAKAGFPAGARIKSLANLRNKALQPLLDAPKGTFDRVLFINDVHLCESDLFELMLQHEVQGADMSCGMDYKSLEIKEFAPNYPVIFYDVWVARDMLGLPFYNISYPSGAWDLPGGARPMPLSPDRFRLYDLQPVQVFSCWNGVTIIDADLFVNPKHALRFRDDGDTDRQSECYLFCSDLWKTYSPFSSDGNPQDGGRGARIQVVPRTVAAYQHYEYGQVRQDKNTTAFEQEGWLRDKNNLDELIEWKRYPPRLINTYEYAVWSNMNMSVLLQHVVTLSAAPTPFHEKNGLLSTPSPRRMSILLQKTTASDPGSDGRSTTLSAPERRLFSIEGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PNH1</accession>
    <name>A0A2X0PNH1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C027g10403 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C027g10403</name>
        <name evidence="2" type="ORF">BQ5605_C027G10403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PNH1"/>
    <dbReference type="STRING" id="796604.A0A2X0PNH1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ28669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="360" mass="40433" checksum="379E09151555316E" modified="2018-09-12" version="1">MYQHTVVSAAPACGDHVPIRSHIQALCAPMTLIQEQTFATMPRSQGCQGGPSQPRQVLGARVARRVRRARIALKPLKPHVSIRDEIGPQTAVCTHCKARHWECERSKSTRHFGACCSQGKVRLPPPPQPNLEYRQLLQGSDSEAKAFRENARSYNNALSFTSLAAHWDQTQVGTLGPPVFRVFGRLYHRLAHLPGRGHRHSTWTRRRRQSHTKIYFDQAQFYVAYRQSLGEGTCIGQSSRRLGQRVGPAPLPAGRDRRTHNLPTSSTEMAMIICDSDINTGDRGPQDLILQVHGDRCPGVQPKYQIVSSLHPSAMPLRYPLLFPAEEDSSHLNIPLCAFNQFGPLFAKRPRRGGRGRREW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PNS2</accession>
    <name>A0A2X0PNS2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C047g12330 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C047g12330</name>
        <name evidence="2" type="ORF">BQ5605_C047G12330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000113">
        <property type="protein sequence ID" value="SGZ31193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PNS2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ31193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="88" mass="9381" checksum="A858B28D85618C66" modified="2018-09-12" version="1">MLHDCSGGKVSPVTLLPAPSDGSSFGTSGDSCNGSWEVVRVKIRVSKIARIAVANSAPTKKKTARNVPEEMKDFSPKEAVVVDLVIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LP31</accession>
    <name>A0A2X0LP31_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C011g06443 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C011g06443</name>
        <name evidence="2" type="ORF">BQ5605_C011G06443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LP31"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY12254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="544" mass="60163" checksum="C80B9080497D7D1C" modified="2018-09-12" version="1">MRDRDTPADRRERAQAHQKRTAANTKAANNKRRRLDVAVGASQINAAKKQDAWQRHKAAKEQKEKYVQTSVEPYSDEDSYIDPAIKYLVLGGQAEDPCDFSDNGQDEADSDEGEDLVGPTVVDGADGAAPVAIVNMVATSIMDDDDESVIPGVTPQPKAKALQSSIAGQATRRNPPQGRVASRTPGSSSSFARSSPLVKGNLNVNAPYDGAHNRKPIDQETLDSKPTRRQASDLTLEQKMVAGAWFPTIFMQNILDGQGLWRTKKSLYAQSQLVAEVYNENAERPIEWSSKIADLIVSKNLGVLNLIKRTALKYTCKAYKLDPDRQREASTAKAVLYLQPTKWAAKELRCGAGTRCGHMFWHQAAYNIFLPQGGVDMSDSSFEAEDDFQNDLLYEIFVQIVAGIRKEKSAAFQWPKEGLDPNDNDHRELVFALLTHAYAGVWYAMQVLTPPPSLPESSDAGRNVNVAKQTVALWHEFSATHCQGPVMAILPMQVRVTNRVQNSVEVALLEEYRLRGPGVSGRGTSDEMRITAQRACDFEESHFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LPJ5</accession>
    <name>A0A2X0LPJ5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C011g06586 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C011g06586</name>
        <name evidence="8" type="ORF">BQ5605_C011G06586</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LPJ5"/>
    <dbReference type="STRING" id="796604.A0A2X0LPJ5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032435">
        <property type="term" value="P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903094">
        <property type="term" value="P:negative regulation of protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22562">
        <property type="entry name" value="UBA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="6">
        <location>
            <begin position="5"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="7">
        <location>
            <begin position="250"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="43"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="134"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY12714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="327" mass="35269" checksum="006D17F5A1E2970E" modified="2018-09-12" version="1">MSDKETLLSMGFFEAQVIKALSATKNAGLSQALDYIDEHANEPSGFWDVPFEKPAKTTTGVGEHEEGDEEGAPGGAAEAKSLTCTDCGKRFRNHALASYHGEKSGHENFEESTEEIAPLTEEERKAKLAELQERMLAKKKLQQAKDREEALKNDAIRRKAGKDQAQIKADLQLKAAQQEAAQRAKDKLEDAKARATIKAQIEVDKKARLEKAKREKALREGGIVDVGEEAAEIAAGTSAGGLKSASAPVKTYDQTRLQIRVPDGPPLVHAVASTETLGAVVEWIQGQTGLDEPGLSSAFPRKTYSPSEYGKTMSELGLAPSAVLMVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LR68</accession>
    <name>A0A2X0LR68_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C013g07212 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C013g07212</name>
        <name evidence="5" type="ORF">BQ5605_C013G07212</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LR68"/>
    <dbReference type="STRING" id="796604.A0A2X0LR68"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017984">
        <property type="entry name" value="Chromo_dom_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00504">
        <property type="entry name" value="CHROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="4">
        <location>
            <begin position="22"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="77"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="170"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY15021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="310" mass="34696" checksum="7C7BF2EA33A97E80" modified="2018-09-12" version="1">MAKRAVAIPESDEEEEEEEEIFEVSKILDHKHAPKVGLQYLIRWKGYEDPSEDTWEPESNVNETASAKVKAYWRTVSADRRGDQKLSKLAPSPSAALAKKRRSSEQSARGKGKAQAHNSDSETDEDEDRRHPPKKARATTPTADGNRAPNSASTRKKPVVPVEPKAEEEEGKKPKENIKDKKDDKIRNGTKSPEKADDKKTSVAGEQDAGSNGDDTVDGYEAEGEETDYHLTKYADRATFDDIVDHIETIVAGDKKDGHRMMAVWKIDGTHSYLPEAIWRRKCPQAALDFFVKHLKFKPTNSENDVGDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LRU4</accession>
    <name>A0A2X0LRU4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C012g06735 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C012g06735</name>
        <name evidence="2" type="ORF">BQ5605_C012G06735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LRU4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY16018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="125" mass="14003" checksum="6E7D136F0C7017B8" modified="2018-09-12" version="1">MPQCGEQSFFACACVAVLLGRVGCWWVVLCRPEEACSDSAAAFTARALEQWSRETRAIDSAEEMRLQDLTATDISRRCRLLGGDADVGVMARRGSRVERRCRAPNREPGRSSLHQSTRSRRTKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LT83</accession>
    <name>A0A2X0LT83_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C015g07773 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C015g07773</name>
        <name evidence="2" type="ORF">BQ5605_C015G07773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LT83"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015953384" evidence="1">
        <location>
            <begin position="24"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY17402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="155" mass="17706" checksum="C794A2905B2F15FF" modified="2018-09-12" version="1">MGFFQTVVTVVATLSSLGNFLAAMPLLRGEHPVVSSVESKAIELQGSRNELPYRVYSDYWPSFTYPTGGEQWEDGSEHIVRWNQKLPPYATYSQVPQTADLVLGHWDKKGMQSGENIELKHPLVKNVSLYIHGQNFVKFRLPCMRHLKENLSERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LTC5</accession>
    <name>A0A2X0LTC5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C011g06452 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C011g06452</name>
        <name evidence="2" type="ORF">BQ5605_C011G06452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LTC5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY12276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="354" mass="39898" checksum="67922CD9E49A6853" modified="2018-09-12" version="1">MALEIQKADILPGGKLRGEINEWYLESERLYYNGRPAHLKISPYSSHAVLHIADFILWHGPPCSTWCFVIERYNQHVKALTSTRKLPYSAIMRGIMVDNAMKSIAARYPAVFYPASKRKVPSGNRLEQPGPQVEQSLGDGQAEPEAMEGCELIGAKTIQQEKLSVHVKKLLITYINCTYALEPNKRTVCTKILSEGLLIRKLLPKELTIAYTAILNGSRIVGSSQPSPRGPSRREAFTYTLFVDEDARRSRNRSRPFVGVEHKFYGEALEFYRFNLAHPHTVVVVRQADGLVAVGPENAQHFHNIYRYKKQGPLEAVPVQQVLTVAGQLHRKLDSSFMTGADVGPANVWYFCFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LTL2</accession>
    <name>A0A2X0LTL2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C011g06542</name>
        <name evidence="4" type="ORF">BQ5605_C011G06542</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LTL2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="3">
        <location>
            <begin position="150"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="748"/>
            <end position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY12569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1054" mass="118384" checksum="4B5A8E8AAE325CD0" modified="2018-09-12" version="1">MGYLFKLAGGVILWSSRLQPQVACSSTEAEYLGLLHAAKEAVFLCLLLTELGLDTLSPLRLLGDNQGAIALTQNPVFHARTKHLRMLEHFVWEHIQNGEISVTYIPTHDMVADIFTKPLPRAIFQRNCDAIGVWRISGQEQGGVLKYFQLFLGGRLFQKFVADTWALTEQERLYWMRINQKKLRAKEYLSLQASLAEGLDPAQIGKRVILPLSHAGLPRQMVQLYQATMAIVRVFGAPDMFITMTCNPAWSEIVNALLPGQTASDRPNIVARVFHGKLKALFGGVLGVGRAPGVFGKVIAYVYVVEFQKRGLPHAHILLIMDPEDKPKTNDNYDKIVTAEMPDRNRFPALFETITNSMLHQQCDCPGKHTCHDDHGKCTKRFPKRLQPRTTSEDGGYPHYRHCGIHQYVKFPGTAQEEVYTDANVVPTNPFLASKYNCHVNVEIASGVAAIKYLYKYVYKGHDRTSFTIDKPRAQDEINNFLDARYVCAPKAIHRIFRFRMHDWDPAVAILALHLPDEQQLWFDPDHGAPDLSAPPETTLTAFIKLCAKTPPDHNAQDLLYVDVPTRWNNKDCAWVPRKVPSPTSFADLKIFNGVEFRTFREASVERGLIHNNAEADRCLTEAAVFCTGHELRHLFAMLLTADDGVTNAAQLWTKHYDNLTQDVEYQLRNQRRQPNITPEHVASWGLLQLSNILQQLDSSLSDHGLPLLTIQFDDKASTNCLIMEESATAAELDEVEGLWRNNFESCNAEQRVVVETVLDSILNSRGEVFFVDAPGGTGKTFLEETVFARIRSEGTYALAVASLGIAALLLPKGRTAHSRFKIPIDIFDDATCNVPKQGQLAELWDEAPMQHRRCFQLVDRMLQNVQSSTARFGGLTLVLAVFSRCLPLFPSNRLRKSSTLASWNADFWGEVEVLHLSVSSSPCLTFRPYTNNGTVRAQTNMPLLAAADRMIETERAKAQGSADWLLGVGDGSANKTEDSIALPRNLLLQATKRNIRVDQTRLSRKKVEYFRERAKLVPKNSQVDHINNMVLDLLPGDAQTFFSASKTKTNHCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LU13</accession>
    <name>A0A2X0LU13_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C011g06620 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C011g06620</name>
        <name evidence="2" type="ORF">BQ5605_C011G06620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LU13"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY12828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="366" mass="40993" checksum="50DD464A4241131F" modified="2018-09-12" version="1">MSVQLRDLEQVMEKGTPCGTRTPAQPPARSRYTSVPDSSHPRYPFPSQNMMIIVVFLRSHKRRVGVQELDDMLAFAKAFGVQGLPAASSVKKFLASLEKEIPLFKPRQYTEEDSRTLPSRGVASRLHRCGSILQRLHWPLSCEARRRIKDALEWMKEDRKELPGVGNELGHKRLVNLLTAVSNEWVGETLINFLIGGIIHTQQLEHTTTILVYGLVASHTLLRDADDSSDVQRLLGQYHFELWLADLARHDCIGIASSGTAEFIRAHPDSEIDVKHGAWSIHNSLSSRTLTVAAALNALEALFKVLNLIIDVNHGTTTRAPQQQDTFSCGPAIVNVVEHKLVHEKPFDPTHAALSRIRQFCRAIDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LUD6</accession>
    <name>A0A2X0LUD6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C014g07608 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C014g07608</name>
        <name evidence="8" type="ORF">BQ5605_C014G07608</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY19297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0LUD6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140567">
        <property type="term" value="F:membrane protein dislocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140570">
        <property type="term" value="P:extraction of mislocalized protein from mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19520">
        <property type="entry name" value="RecA-like_ATAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000538">
        <property type="entry name" value="ATPase family AAA domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051701">
        <property type="entry name" value="Mito_OM_Translocase_MSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644:SF3">
        <property type="entry name" value="FI08533P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="1290"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1505"/>
            <end position="1528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY19297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1528" mass="170960" checksum="C31C96E5D1D87E70" modified="2018-09-12" version="1">MMSTTKIPNVSFVAANVQSINEDRKRASLFSNLRSHNADVFLLSETGRPSPERVAQWTQECQDLKLSALFTPFNNTAILWKSDSVVITFDPESPPNTLRASFSFPDRVTDATFCVGDSKVRVVSIYAPSSDKPDKKRFLSHLSTALRQVVRDEPSPPALLVGRDWNCVESQPLDSENQNGTNYGGQEMRDLATANNLFDAYRLHHPKGRATTNRSAPGTCRRLDRIYVSPDWVDLFHDHKIWAPVLKSTHSMVVARFQVPGAIDIGPGKFKLGLHVIEGDATCEYLTSIVRTLYNKALLQTPNDPPAAWTSTKHRLLPELQALARTFARFRRGGSEQERADHSRYGAALRSRLDPSLAGPSSIFIRLRKVRASDLIPSLTVNDVVHSDPDSMLGAAGDYFERVYEDRPIDDAVLKAIIDGLASTRLSPADSLKLEEAYPLEEMTKAQAACKSNSSPGPDGLPVEFYRATWPATGPILRDVINSIPTEARQPGPLPRNTAHIHLIHKRGERDQLSNKRPISLINADERIISQAHNQRLAPLLESLIGPTQRGFVPNRWIGTNIAEVQCLMDPGLPGSTPVSGMLAVMDFEKAYDRLSHPYLDAVLCAVGLGPKARQWYRATYTNQSASIFLNGWLSATFDILSGVRQGDPLAPSLFVLAIEGFACQIRLRVKGIDIAGLQNVRELLFADDACCALHNLSDLDHLNRAIELYERASASKLSNVKSFLYPLGAFRDRSIAPDLGTWRLSDSQFRYLGIQVGVEIAEDAGWEDVKASTIARIRSVPMYDLPYASKCSIINIYCYTKILYYSRFLPAPKSVVKEIEEAAMLAIHGRASDGTQRHPRVSRSRLCTPLDHGGFGLIDLPRRLAIDHAKWVFQLRAPDGCFTRHLFDIRIRLQAPSEPTPFTLSRPAPNQHRCPWIWIWWAYFCHPPPKWDHAVRKTTKLLPARWVRYFEAWALVTTLNPPELSKSQNLEQWATHVLYFPAGHGIQLSVNPTLFRGPDGEVMTPSSFVNASKRHQVFIFPLIFPKGHQKVFDLPEQRWNAWWKALRKVRWVHSDAEDTGHLLSLGSLHPGSQVCLAHLAVGCPFARRLWSALSPTPLPVFVDFVCPVVSRSERRLVELRVLFFHSIWKLCRRRRFSSDLLEPITETDFEGLRASIQESKGRLVSLTRKIVQDVALFAVSQVLFYAAFKVPRAYAQAVMSSMDPQSTKRKEAKDKSKKALSKLGLDLSTLDLTEHEEIIAGEVVHPSEINVTFKDIGGLEPIISQLREAVIFPLCYPQVFESAAGLFGPPKGVLLYGPPGCGKTMLAKALAKESGATFINMHVSTLTDKWFGESNKLVAALFSLAKKLQPSIIFIDEIDSFMRERRSSDHEVTGMMKAEFMSMWDGLATGNDTRILVLGATNRPNDIDAAILRRMPKRFSIKLPDSQQRRNILTLMLRDIKLDPSFSMDSLVRRTDGLSGSDLKEACRNAAMVPVRDHMRSHSVGGQVDLEKIKQGNFKIRPLLNGDFLQPDQPANGRYATEPEGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LUJ4</accession>
    <name>A0A2X0LUJ4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C014g07678 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C014g07678</name>
        <name evidence="2" type="ORF">BQ5605_C014G07678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY19546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LUJ4"/>
    <dbReference type="STRING" id="796604.A0A2X0LUJ4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY19546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="478" mass="54776" checksum="333CA8C789F40656" modified="2018-09-12" version="1">MLSESLNGRGVSSGSDKYGNPRCKRHFPREQNPHTRMHPEGYPLYRRRFRHAVVKGGVIYNDGDCVPYSPYLCAKYNAHINVEAVTTIGAIKYLFKYVYKGPDRAVARVERAANGEGAREDEPVRDEINEFVEGRYISAPEAVHRLFGFSVGRVWPPVNRLPVHLENQQSVQINPNEPLPLDTPPTRSKLTGFFDLCAAAPDGELTTTLLYTNVPRYYSWNKEKLRWKRRVHDRNVIGRIYTVPLRSGERFYLRLLLEVVMGPTSFADLLMFEDVVYPSYRAACAARGLLADDGEHHICLREAAQIETGNQRRRLFVFMLIHATVANPPALLERHFASLSDDARYHIERYEDVPVNDQTIRLWTLNKIRLLLAANDRTLAFFDLPELTEDEVRLFDRLEERLPRFDRQQCAQDAEAAHARLNHDQRIAFDECLCAVELDVVDQMRDNNLGPQHVFFLLAPGGTGKTFVENALPAYLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LVH6</accession>
    <name>A0A2X0LVH6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C013g07251 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C013g07251</name>
        <name evidence="5" type="ORF">BQ5605_C013G07251</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LVH6"/>
    <dbReference type="STRING" id="796604.A0A2X0LVH6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03357">
        <property type="entry name" value="LbH_MAT_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051159">
        <property type="entry name" value="Hexapeptide_acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416:SF23">
        <property type="entry name" value="ACETYLTRANSFERASE C18B11.09C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416">
        <property type="entry name" value="SIALIC ACID SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Maltose/galactoside acetyltransferase" evidence="4">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY15116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="284" mass="30533" checksum="FA56CF0DD9C04E9B" modified="2018-09-12" version="1">MLPQTLQPHTQIPAASNSSAGASSDSAKDVAAAERALIERKKMLAGEAYDSMQDQGLLEGRLKARHLLHPAPPGREHRGRMLMGPHLGHWTSPLAQAYNHHPPATYVKGMNGAEYFGEDCGITLLSFPFLCRGPDSRWSILAELFQIPLEKMKKIAIEPPFYCDYGCNIKFKGEFYSNFGLTILDCAEVTWGERVIVAPNVQVYAATHSVDVAERQAGLERAYPVTVGDDCWIGGSAVLIGPCTIGSGCTVAAGAVVRGTFPDNCVIGGTPARILKKLDPPAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LVT8</accession>
    <name>A0A2X0LVT8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C016g08248 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C016g08248</name>
        <name evidence="1" type="ORF">BQ5605_C016G08248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY21522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LVT8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY21522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="54" mass="5916" checksum="CE74413A39C4B395" modified="2018-09-12" version="1">MIEVVDRPGELGDKARLGAVAATGVDMKYLLVYEICCGRAKKGKERCKDLASMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LWL3</accession>
    <name>A0A2X0LWL3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C012g06954 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C012g06954</name>
        <name evidence="1" type="ORF">BQ5605_C012G06954</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LWL3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY16696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="145" mass="16388" checksum="29DC9B23FE8DFEFC" modified="2018-09-12" version="1">MVRRCGWGPRPVGFSGQIGTHFGHVRLGKPKFADPQEQRERARNIPGLRASLAFPTTSRRRRLCHHRQYPTFSARLALTKRRGPDIDLFDDDFERMAPLLDVRVSELFASSFDKPANAPGFSLNSFHGRQTSLSSLNPLLGRSML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LXC2</accession>
    <name>A0A2X0LXC2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C015g07929 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C015g07929</name>
        <name evidence="3" type="ORF">BQ5605_C015G07929</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LXC2"/>
    <dbReference type="STRING" id="796604.A0A2X0LXC2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="158"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="286"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="347"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="642"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1029"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="508"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="238"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="354"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="485"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="642"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1034"/>
            <end position="1046"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY17923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1053" mass="113668" checksum="F531903902D80FA4" modified="2018-09-12" version="1">MSHPSDPRCDDDSGRLGFDFMSAALQCGSSQASPRQDDMRYQVQAHRAQQYLQANVYAGASGSWGAQIESGYDASNFIDQSYASYPASDLSAVADPRCSAVTTQPGHDRSLASTSRLSESIPSYSQSVGTAYQDVTSSSSYSDGTPGPYQLLAYDAHHRPNSTSDSYPSADAYSYQPDPFRTQHPLEHSFDNSHTQFALHDNHHGPDWSALQQSQQQEPPFPRPHKQQRQEQWPGAMHSQSSSTPRHSVNSAPFEAPMHTVVSDLGPYAPYQSEWRYHEYPALAGSVSRSSSTSRTSTHSSRHPSYPASGEWASVANPAQLQAQQQPHLQHTGHYYLPHEYDAPAAASMDHGYHSSSPSALDQSWNGQSNAALRPNGTSHPVPLEEAYDSSRNPSAPLSAAPQGGPIPLRYASPVSLSRGVLGTSNTSDPSWHGPPTGNLNPAIYSSSHAFTFAHNALSTNTAGTHSSKSGFYDSRLIATPPMTPGSAPGSSGSATTSEAASSPSAVVLVAAAERRKIREELAAAEEASKNLAGSPGNLVPSMIPGIKAIAVKKSTQPGSARPCLELPVSCQMCAEPVGKLSLRGTSIDKAKDQVVPRGVYYCLGCVPVSTRDKPSSANREPEATYADTLSAAVDRLESLTLGRSPNHGASPTGSAQHRSAPHAAPTSASKKRVKGEENLLTCDICRRDIGSGELTCVLKDVPLGTEVEYTPEVACASCLDKYRRCSDCGGGGGTKGVGRWRARELFPGGRRTCQLSHARQGSLSEMSYDVWPITSLPPDQLPDLVAMCRELYMLHVLGTLAVPDMMESAAPLASTFEQVLLLATDSWPSFEKAIRENIEPTTSTRRYLALRWMTARKPRSKGEKSRGANTPSLTANGRTPAGFVLAEQDLLLGSCYITVTMPTGTGESYDATSRLMHSLFRHIQNDIASINIVRGRQNEPLLPLLKHAWTLHFEKRESRVMNRPEAKRGFVTLEEYLATYPDVDEKHFSPYRQVWLSNDLLKYWTCYVKRITDNDDWLVTNTRRITSTSAGSSAGGNASGGGGGAPPRSSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LXF5</accession>
    <name>A0A2X0LXF5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C015g07969 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C015g07969</name>
        <name evidence="2" type="ORF">BQ5605_C015G07969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY18071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LXF5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY18071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="402" mass="44305" checksum="EEB492570A0449AF" modified="2018-09-12" version="1">MASIYRSSSISSFDSTASTSSYASSSCSPNDVIASDSCRCSRKSSSSPIHSLPFELIHYIIDLTLPSDHSSRTRVLLSYALVSRFFLLPSQSLLNASIKLSTSSAANRWLSSKRPSTTSSSHLITHALSMAGIVAGHGISANTARKCLLKAERVSTVELFDFKSLPVKALQGPSLSNLHTLYLSTSFVPLPRSSFPLLLREPLYLPFRSTLRTLTLSGTPSIPSPLLFALLQCPYLTSLTLSLVPRSSCYPNLIEALPLALGNGLKELAIHHPPDERFLQDAFGPNSPHERRTSASIGASNLTHLSLHPKVPLDILLEKLSASRHTHLQHLDLTISYNVQGMNAILRQHFLVGGGGSFHRLKTLVLRGTREREWDRFAKEEGRWLTQVGSEERRFKVEWIPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LXI4</accession>
    <name>A0A2X0LXI4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C014g07423 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C014g07423</name>
        <name evidence="2" type="ORF">BQ5605_C014G07423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY18643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LXI4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY18643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="79" mass="8282" checksum="9280CF130BF514F5" modified="2018-09-12" version="1">MRRKLRNRKGARTGIGPAAGEIVGALRQLRASKPSPQGGGLAGARNTRGAPVELRVDSSQPFVSRPLTQAAKPPPSNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LXV1</accession>
    <name>A0A2X0LXV1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C014g07524 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C014g07524</name>
        <name evidence="1" type="ORF">BQ5605_C014G07524</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY18975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LXV1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY18975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="57" mass="6297" checksum="690C6C14327B789B" modified="2018-09-12" version="1">MDTPLNYCQKWSLPCPSKVISSASESDFPIGSGNRLYLKDTQGYKSLVTMCVHQPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LYA6</accession>
    <name>A0A2X0LYA6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C014g07704 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C014g07704</name>
        <name evidence="2" type="ORF">BQ5605_C014G07704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY19618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LYA6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY19618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="61" mass="6527" checksum="8E5C83960981821A" modified="2018-09-12" version="1">MTGPHCPVAFSCLSGASSHPVGQIKPSLQSSLFTDCSLMMTTTQSNEQGREQSDEIPKELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZU4</accession>
    <name>A0A2X0LZU4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C019g08826 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C019g08826</name>
        <name evidence="8" type="ORF">BQ5605_C019G08826</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY22605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LZU4"/>
    <dbReference type="STRING" id="796604.A0A2X0LZU4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205">
        <property type="entry name" value="FOUR AND A HALF LIM DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205:SF16">
        <property type="entry name" value="GH01042P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="266"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="90"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY22605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="478" mass="52468" checksum="8A68A5261861504A" modified="2018-09-12" version="1">MHTPSLPLGNDYRHPAAPSSIETTPQPGRPFVSNTDATAVHHAQLVAHYWHFAQQGVVAPVIEGDLYQWRAREEALEWAQRHGIVLSHPENSPIPATVHGGAASVSTPTHHMPTSPAAPLPDGPRSGRPLPTPKPNPPVPLAPSVFSLPDSNRPAPSSTSSVLPAVFVEGNECVSTPSAALLTAFPVDEASPSQADDTSEVPTFTMILEDERPELRSAVNLATTVDSKTLTSPLPPLHPRFDPSHPSHYLYHPSSSAPALFDNDNVTCHGCDATILGRKLLAMGKQWHPECFVCSLEGCGQRLEHVEFDGKDDRVYCILHFEELFADICYHCKTPITIDQVITIDDPRLLPPTRRTYHALHLFCSSCGDPFIEPKLLLPDKDEATPDPYTIHEGFVYCENCDLRLWKPKCASAKCGHSGIANGWIEIGDQKWHEECFCCKEYFTDSVYFQMCDTPLTGSYMVPEGGQNEVLCLACFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZW3</accession>
    <name>A0A2X0LZW3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">deoxyhypusine synthase</fullName>
            <ecNumber evidence="7">2.5.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C016g08092</name>
        <name evidence="11" type="ORF">BQ5605_C016G08092</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine</text>
            <dbReference type="Rhea" id="RHEA:33299"/>
            <dbReference type="Rhea" id="RHEA-COMP:10143"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57484"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="EC" id="2.5.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.46" evidence="7"/>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY20557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LZW3"/>
    <dbReference type="STRING" id="796604.A0A2X0LZW3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034038">
        <property type="term" value="F:deoxyhypusine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.910.10:FF:000001">
        <property type="entry name" value="Probable deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00321">
        <property type="entry name" value="dhys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703:SF0">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY20557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="361" mass="39816" checksum="98A28786953C5CB9" modified="2018-09-12" version="1">MADASAKAAVFVASEAYDGTRIQGPDFNQAHDLEQLLRSYQTIGFQAHGLSRAIELINKMRAWRLSDEKMDPDAQTEELDPEIRAATKCQIFLGYTSNLVSSGLREIIRFLVQHKMVTCLVTTAGGIEEDLIKCLGPTFVTPGGEFNLDGAGLRKRGLNRIGNLLVPNDNYCKFEDWVVPILDTMVTEQQAGQTWTPSKVINRLGKEIDDESSILYWAYKNDIPVFCPALTDGSLGDMMYFHSYKTETALVIDIVGDIRRLNDLSVKSKKAGMIILGGGVCKHQIANSMLFRNGADYSVYINTGQEFDGSDSGARPDEAVSWGKIKIDGESVKVYADATLVFPLIVAATFGKAHWDAQRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M0E0</accession>
    <name>A0A2X0M0E0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g02008 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C003g02008</name>
        <name evidence="1" type="ORF">BQ5605_C003G02008</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY38362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M0E0"/>
    <dbReference type="STRING" id="796604.A0A2X0M0E0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY38362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="213" mass="22438" checksum="C24836C579CA7014" modified="2018-09-12" version="1">MRLVCAACLSPKPMRPACSACLSPGPSGEWIPHTQAKFFEDRFFPAAANPVPTVVAPAVLSYPSVPRRVPPPDLPPDNDDTLNPAGVAPAVAAPPAAGLVDIVAPPVPPSLVFSNPGPANAPPVGDRSTRARRPPDYLGFARAAHDLEFAAHASVSIEDFDEDDPDVQLYSYEEATAFLAKVDRDNTPSVRAALAATAEATGGVMLSRLLKRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M266</accession>
    <name>A0A2X0M266_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00068 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">BQ5605_C001g00073 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C001g00073</name>
        <name evidence="2" type="synonym">BQ5605_C001g00068</name>
        <name evidence="2" type="ORF">BQ5605_C001G00068</name>
        <name evidence="3" type="ORF">BQ5605_C001G00073</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY43835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY43870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M266"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY43835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY43870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="95" mass="10666" checksum="5C031D37F454B3CA" modified="2018-09-12" version="1">MRGWGIPSRACLKWVATLSNASKTWESRHLQELASMMHVTSLPLLARLVRTKRQEEFGEPGLVSSDSGAESEDDDDEEPLDQATRAALLDEMMYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M3L7</accession>
    <name>A0A2X0M3L7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g01874 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C003g01874</name>
        <name evidence="1" type="ORF">BQ5605_C003G01874</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY37726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M3L7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY37726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="281" mass="31202" checksum="009756EC53D641AE" modified="2018-09-12" version="1">MTRTSRHHTSATCQNNRRETDPYSLNFVAAISRYVNTCRDTSAHPHNLKAFKHTDQSCSTATGPALSVYTFSFYDLHARMAQSQELEADSINDWIAGGQHFADSIIINEMKPLPQLYRSVMGQIAVACNRKNSAMQHRNGLMTLACGANDRLTTFLYDCGLTTDISLGDSPGSCELDEGELKEIGSNKYFHVTVDNLLHGTFGYAHIQNGDIAGAYNLRAYSAHQASLPLVISSISSQLPNPTRYLQPGSMFRYIERLLDWFFILASVFTVLNAHHPLSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M3M2</accession>
    <name>A0A2X0M3M2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C001g00530 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C001g00530</name>
        <name evidence="7" type="ORF">BQ5605_C001G00530</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY47415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M3M2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06179">
        <property type="entry name" value="MFS_TRI12_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053791">
        <property type="entry name" value="MFS_Tri12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF195">
        <property type="entry name" value="PEP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="397"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="40"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY47415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="586" mass="62174" checksum="A445FFE0DF1DBA28" modified="2018-09-12" version="1">MSAPTLEKHEDQHIDRIEGFTHPAECETLDTLITWRSWAYAAIGCMFYFTISWHLATTSIFRSSMGAALGNSAQSIWLINIVSTFQACVGPPLMYASDLFDRRWILVVVSFIAVVGSVVASRATSFGMGLVGQGIVSIGMSAVGAGYAIPAEVFPRQHRGKVQGATNFAASLGGGLGVITSARLVANNPLNGWRTCFYIAIGLFSMMFLLLLIVYRPPPRPTEERSLPFGQKLARLDWIGYVLVIASLCLFLVGCTQGGTNVWKAGKTLGTLVSGIALMVVFGVYEWKGTEVGLFHHAMFSHRNFPLALVAAFVEGTIFFSILAFLPVAAAGLWAPQDAFKANIYLAPFYLTSVPLFFVNGWYVDRFKEFRLPLVIGYLLYLGACIGLALSDRNDSAIGWAMSSLAGIGFAAPIALLFAVAQLAVPGKFIGSASALMVAARAVGGAVGVAVYSAVLGDKLSVAIPARITAGAFKGGLSPAQASTVLPKLIPLIASQNPAIIAKAFMIPGIQQGIVLGAIEGVQSALAYGLSFVWYIAVAFSALGIITVLTFASSKDQMTSKVDAPAERASAAVYSDSKSQQSSQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M3S3</accession>
    <name>A0A2X0M3S3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01660 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01660</name>
        <name evidence="2" type="ORF">BQ5605_C002G01660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY34622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M3S3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY34622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="58" mass="6885" checksum="C1970FB4F148972C" modified="2018-09-12" version="1">MRSKIGDFPGFYLRASGWAFMGPLTARLRLLARFVCIRKAVRKRSYARMRPYAHLMHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M4U8</accession>
    <name>A0A2X0M4U8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g02143 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g02143</name>
        <name evidence="2" type="ORF">BQ5605_C003G02143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M4U8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY39101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="210" mass="23236" checksum="E2B32ADF38ED6234" modified="2018-09-12" version="1">MPHTIPPNFVETAAVHPVGTTVDHHTAYPTGEAVVPATYNDASPAHTPLDERSRSKSRDPFWKRTSRSQSRDPEYQKSQQISATFGQIHAAQASTEAGEIDRATRHSLRDGEHGSKSRSVSHIRQMVKAIAHDPFFHRASAHQTEEERAVELHQVILGEIQAAKASSAAGRVDREKRHASRSRSRVREAVHGLLQKPDHETKGIEASKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M5D7</accession>
    <name>A0A2X0M5D7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C003g02232 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C003g02232</name>
        <name evidence="6" type="ORF">BQ5605_C003G02232</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M5D7"/>
    <dbReference type="STRING" id="796604.A0A2X0M5D7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045152">
        <property type="entry name" value="EDC4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15598">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15598:SF5">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="88"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="586"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="648"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="679"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="938"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="947"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="980"/>
            <end position="994"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY39533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1145" mass="122606" checksum="2D993319324F2F5A" modified="2018-09-12" version="1">MEVERAALQTKGPEQIISNGSTPQTRKSSSQNIVKEEKKQERAATPGSVPKFGAFVSPFDILAQAHAFELQHEKNEAVDPKTKVSIVTSEAEDLPTPRPASAAPPSVPSNSTHPASQEHINVSDKAGNDAEEGQALTATKAAPLDLLVKKYLSDSPSHAPKWAPRGLQLPPRRGSIAPPMAQHLTIDISAPNLDSLDSAALVETTPVVLFEVPYEWSPGRCSAITSHVFVWSTSKGRIRVVDRRSGAKILLKGHKSAIADLSIAPAPEADASRMITSIGVDGRLIVYSVPDSFSQDNAPTHKVLELEGSALVEGARFRSARFHPQFPTVPRLALVLGSSSVLIMHLERARMPDVSIESAVRTANCGEGLASACFSPDGTAFAALTVGSEVTIRKTSAPEKILWSRSLTPADGAEATEIAFLTTSNGRPAGLVLAAREGSHLQLLSLSRGGHAPPDPNSIEFTLSAKVEEAQSCTNFAHLFYHQPSTTLFVSSSARGSLFAFRIGVDESESSRSAPDCDLFAHQSELTEPRVEHVAEIATAEPLIEISVDEAFSGARSSDTPSLSTLIAHPGGLHAVTFDFPGLAVGKGRGHDSDDDDEPYGGPGRRMSLEGSIRVESEVEVVVDVDEVSTSSPYSRLAAKLKLEDPIQEEPGSVAAEVPQVSSRDGPNGLEGNIPGWKATHNQVEDPVSHPSTPARGQKGAKQASVTPDVSRELRRVEDRITKAIQKEMQMQAHHAAEERVNDRAADVARQETLLKLVSSALSKKLDTTVREQMRAQVIPSMSKLVTASINEQVARGIEEAMSESVSGGQTLPRELRKLLSRPEMSNHIAQSVSAAIVPSISEAVERQLLSVVATGVIPGFNSSLASAVEGVMQSVRDTVLAEMTDVRKEIVQEQASAIVELETLVGDLKGEVSELKTSLVRMEQLVLSLCNRSSASPVAAAPNCQPGASTSRRQASVSQAQPHPPTQQVVHAPIQRQPSSSSALSTFTHSQSSDGDYADEDYEELFTDALQPQHAPEFAELLSIIGSSSPATADRVLPPTSLPPRISPPVILSLAYQLAGRLSGQPGPFNAEARQYLLWVQKCLSAMDRKAEEVREFVPKVIETVIVCLHAKADTIAASHDRRGLDEIRAVERLAHSQLRQFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M698</accession>
    <name>A0A2X0M698_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C001g00078 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C001g00078</name>
        <name evidence="6" type="ORF">BQ5605_C001G00078</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY43897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M698"/>
    <dbReference type="STRING" id="796604.A0A2X0M698"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="5">
        <location>
            <begin position="56"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="9"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY43897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="334" mass="34943" checksum="DA9786C2CFE88CC6" modified="2018-09-12" version="1">MSSIYNFFAGPAMTNEGPEPPLPPPAPTPSGSSGTTGQSGWSSTTSMGPPSSLRGRTYIVTGAASGIGRATAIHLASLGAHLALTDIDAELGSETCQLIQATGSKIDVVFATMDVTAWRDQNLPKTHSPPIARNGSETDHEAVVKLVRKFYGTFKRLDGLVNCAGVQLPSPLAHEAPADLMTKMLDVNVKGAYSFCQAFIAPIMQQGEDWQAPVGGYAIVNVGSTASLRGTVQSTAYCASKHALLGFSRSLALEYAAYNIRTNVVAPGFVSTPSFHDHFSSDIVDQTEAEATASVPMKRIAEAREVAHVIAFLLSVESSYVTGAVIPVDGGASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M6M6</accession>
    <name>A0A2X0M6M6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g04319 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g04319</name>
        <name evidence="1" type="ORF">BQ5605_C006G04319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY57895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M6M6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY57895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="300" mass="33757" checksum="1C4277C9D3E5E422" modified="2018-09-12" version="1">MTTTRGESGRTVSFASRPLMAPARPAQPFPSLDQLVIGTAEMSLRALEPKTRSDYARAFCQWNLFVLYYRYPALPTVVSLCQFVYWWYRLVSTVYQTLSCLAHYFKPIMGDEWNRIRSCRAVKLVIIGGIKTWRRAAKRATPLPFASVDYSLKAGVSDAAVSYDHLVFLTMVALGFGACARCAELCAPNTVAYWDYNKLPCHDTVKIEKDSFIVHLPYHKADQRWQGLHFIVVRILLHETNNSRTQTSSSLRAMVTLPHVHGSSVVFEASSDRIAAGNPSDPAVQPTTLYEATQRIRSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M701</accession>
    <name>A0A2X0M701_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C007g04467 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C007g04467</name>
        <name evidence="2" type="ORF">BQ5605_C007G04467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY60685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M701"/>
    <dbReference type="STRING" id="796604.A0A2X0M701"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016147732" evidence="1">
        <location>
            <begin position="25"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY60685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="421" mass="45194" checksum="A5F016D0FD707850" modified="2018-09-12" version="1">MMPVMTSVPALLVLALQFSRLVEATPSRLEPRRGTKFAALMTDRMKQCEPSMIEFANSGDARPLTVAIILYDKVPEKLRTDKLLPPVQTTLETIQKLGPLQTFTVKKHDYDPFTFTAVAKRGDKIEVFAFFPNGTGQNMWLDRTIGSGSSSSCLASVCSSTEYLNPKTKKCASCSSLFVNSTSCTAETPKTCSYGVVKDRKCVAKTCSSRQWPGPKGAACIACPDASARSCDAKGKSTSCSVGDVVNGVCKKLTCQDGAYLSSNGRRCLPCADPFAHKCSSANNTTECDWGYALKTNRTASFCVGPYAARFGKSSFMYTTTLTINKTLNATSVVDCAVGANYASVEFPWVWMWSDDGVDGVHCRLVPGGDPGLVRGKPGTGFDVGIVGTCKQNSDWPWSPSPASCAEIFLGPVTVTNKTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M7G0</accession>
    <name>A0A2X0M7G0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C001g00719 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C001g00719</name>
        <name evidence="6" type="ORF">BQ5605_C001G00719</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY48952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M7G0"/>
    <dbReference type="STRING" id="796604.A0A2X0M7G0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45418">
        <property type="entry name" value="CANCER/TESTIS ANTIGEN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45418:SF1">
        <property type="entry name" value="CANCER_TESTIS ANTIGEN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="4">
        <location>
            <begin position="545"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="5">
        <location>
            <begin position="802"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="313"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY48952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1090" mass="120857" checksum="4F36B8D55BA97E22" modified="2018-09-12" version="1">MSRKKGVPNNRHQAQQVPARSQHDGTQQQVGAAATAPVTTPPPLQSPRGHAKLQQQPQQCTSSAAAAGTHASLRTVTEPTPLWAVPSPPRPPPSYDVGPHNNTHKISNMAYNMPRSMMMPLPMAMPMHAVLRPPQPVPTAYNPHVNSLPGAHPVPPPHHQSPYVLSPTTSTSSRPHPAATAATTMLYATSPPPPQVAATQVRPPLKAPLFPPGLDRYAQCYVPQWQKDVNEATQVYFIPQLPPDSHRNLYNWDELFPRKLLADLDALEAKHRAGIISSLPPINFGGTPPPLDAPFVVQSSRIVPVRPGAPRQPVAPPPPPPPPPRVPLTVPAISLEEELRNKIPKLALDTYAQYWIPLQHAEVEARIKQLHDARMYAVPITRAPLPPSGSVAPQSPRLYVLQAPSIREGWPPVELGDSLELRQLRPQQRFVDGQTTSSGTWQGFVFEATIASVYRAKGEVLLRCDGLANHEESMIFNVVWRVQARVFEHWRRATERISMAMISSKHTKDKARSVAQSWLFPEVDDYRQEDDNTEPVVFRGIDGSLNKEQRDAVTSILWAKHKVPFLISGPPGTGKTKTLVEAVLQLLRKHPTTHILVCGASGPSADTLCMRLRSLKPTELFRMNAPSRLFAEVRGELLPFCHVEDGNFALPPLPELLAKRVIVCSLIDAAMLLYARCSNYDLNELLLYTNKTVRPLQPVENPSPHFGFLLVDEAAQASEPDLACALSVVVVDPLRSNGRPHVTICGDSKQLGPVIVSQEARSHGLDVSLLERLAQRDLYAQHPFARKRRQENPHAAWTLGTPFVDLVKNYRSAVPILMLPSTLYYNETLEPCAAPTVQNSPLHKWIGLPRRGWPIVFLGIVGRDEPIDEGASFYNQEEVDQVVFYITALVRSDANSDHGPVHAREISVISPYREQVWKIRLALRSLGLHDVDVGNVEALQGAENRIVIISSVRSDRRWMAADRAHARGLIHEPKRFNVAMTRAKELLIVIGNPNTLLVDSDWAAFYQFCRRNDAYVGVPIEGHSRIDDIAASAQAVSKLEQQWHATHQNGSTPVRNGSYADANGEKVEEDQFRHIDLLVGRMASVTLERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M7Q2</accession>
    <name>A0A2X0M7Q2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C007g04670 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C007g04670</name>
        <name evidence="6" type="ORF">BQ5605_C007G04670</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY62254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M7Q2"/>
    <dbReference type="STRING" id="796604.A0A2X0M7Q2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000328">
        <property type="entry name" value="Septin spn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="10"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="310"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY62254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="379" mass="43376" checksum="2BAAE59CC29651F2" modified="2018-09-12" version="1">MAPRRKSVKKGLQFTIAVCGQSGTGRTTFVNTLCESEVLVHKDLPSPELAHQEDGIRIKPVSVELEEDGVRISLTIVDTPGFGDQINNEFAFQEIAGYLERQYDDILAEQSRIKRNPRFRDNRVHALLYFIPPTGHSLRELDIELMRRLSPRVNVIPVIGKADTLTPSEIRAFKKRVMQDIDYYSIPIYNFPYDADEDDEETIADNRDLRALLPFAVIGSEEATEMDGEVIRSRHYPWGIVEIDNPEHSDFAALRSALLGTHLTDLKEITEDFLYENYRTEKLSRSVEGGVEYHNPDSSILPEDLATQSVRLKEEQLRREEEKLREVELKSQREISEKRQELLAKEESLRNLESRLAQAQAMVQQQSAIYAPSNGQGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M8W2</accession>
    <name>A0A2X0M8W2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C004g02793 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C004g02793</name>
        <name evidence="2" type="ORF">BQ5605_C004G02793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY67644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M8W2"/>
    <dbReference type="STRING" id="796604.A0A2X0M8W2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY67644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="110" mass="12161" checksum="1972FAB8BFA3D445" modified="2018-09-12" version="1">MSSGLEKSLFQLKFTTKQLQKQSRKAAKDETAEKAKLKKALQQGNTEGARIYASNAIRKKNEALNLLRLSSRIDAVSSRVETAVTMRQVSTGRGRGRGRGRSMGMCESKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M996</accession>
    <name>A0A2X0M996_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C004g02940 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C004g02940</name>
        <name evidence="10" type="ORF">BQ5605_C004G02940</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endomembrane system</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY69006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M996"/>
    <dbReference type="STRING" id="796604.A0A2X0M996"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052606">
        <property type="entry name" value="DnaJ_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44653">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44653:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016023989" evidence="8">
        <location>
            <begin position="23"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="9">
        <location>
            <begin position="46"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="270"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="288"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY69006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="340" mass="37959" checksum="C7FF9685B57411C9" modified="2018-09-12" version="1">MKLLRLLPTLLLGVAFSQGVLAWDNEDHEIFDIVSALEQAEGKGTTFYSFVNVTKSATEKDITKAYRKLSLEMHPDKVGDDKVVADRFARLGTIVGILRDAEKRKRYDFFYDHGVPKWRGTGYYYSRWRPGFGTVVASLLVFSCFVHYFILVVSYYVSKMRIKVFHQQALEHAWGAGKKPLAGRKRLHLKTGEQGDPLGVPGINGGRPTAPGAIIQMVVEGTSVYVVEDGEEHLFSEANAKWPSASQTWVPRIIKNRSEWYAWATGNGPVANSSSNGQGEYETTTETRVNEKTGKKETVVVKKPKGPMRGVELQGKVGGRRRVVKPSKPVAPAKEEKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MAD1</accession>
    <name>A0A2X0MAD1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyl-protein thioesterase 1</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Palmitoyl-protein hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C005g03335</name>
        <name evidence="13" type="ORF">BQ5605_C005G03335</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY74025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MAD1"/>
    <dbReference type="STRING" id="796604.A0A2X0MAD1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF17">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="647"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="676"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="735"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="12">
        <location>
            <begin position="554"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="231"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="423"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="467"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGY74025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="761" mass="84313" checksum="DC81B580A6CF9D25" modified="2018-09-12" version="1">MSVMTVLPKGKHTATIIFSHGLGDSAAGWYPFAQALAPRFKHVKWVLPTAPTQPVTLNGGMPMNSWFDIRSLTPTNSSQEDERGLLASVRTISDWVASEVDAGIPANRIVVGGFSQGAVVSLAVGATLERKLAGLISLSGFLMLADKLKSMQVDHAPSYPVFWGHGTGDPVVRYQWGEMSVQKLRELGWKNIQFESYPGMQHTLGAKEQQDVEAWLKKILPEHVASCPGAKLTSVGHRDPSTISFPPAHPSTTKPAVPIKNRSPASQNRRTRVLEVTVRPRFGSAEPDGAKHAARAEDHYRWELQATWTNDGDLNLVKMTTTTPKKSTPAPRNRLPALAEVLRRNTRPPVDLYCYYLFLQREGSEDTLDFWLDVQQHENLCTVNSAPFGGRAYFKDLRKSGRTVREDWPRYHELARTRGSIYGGVTGIRRGDDGREGGEEVPGNTAPASPRPSVSGRPQAFSGSDYGETRVTNEKADGDRRGPSLGGEREDALRTPSPRPRTPASASYPLSPTLQALYPHDSEDRPRNGRLAAPAQPYIMRDTAISRTDLIASAERIYSRYLMPGADKEVYLPPALRITEFTLSSSNLPTVTHPDYDREADAQAQVPDMFHAQKEYVYRAMEQDTFPRFLRAKAFGNLTPISALVRLAFGLLALWVGLATGFAFIFLDKKPKVSRLWVIIPFTFAIINLVAHAYDLDPLLVFMGLSETEDIAAQTPFRTIGIREPYVRKLLFGRALWVTFLSAVVVAILTIIFVLVPGHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MCA5</accession>
    <name>A0A2X0MCA5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C013g07144 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C013g07144</name>
        <name evidence="5" type="ORF">BQ5605_C013G07144</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY14877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MCA5"/>
    <dbReference type="STRING" id="796604.A0A2X0MCA5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051317">
        <property type="entry name" value="Gfo/Idh/MocA_oxidoreduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708">
        <property type="entry name" value="CONSERVED EXPRESSED OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708:SF5">
        <property type="entry name" value="CONSERVED EXPRESSED OXIDOREDUCTASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="6"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="4">
        <location>
            <begin position="136"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY14877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="391" mass="43214" checksum="BE27B6E540EF71E4" modified="2018-09-12" version="1">MSSPPIKVAVLGFGMSAQVFHIPFIQSLSQHFHLTTILERSATADSSKARDAFPEVKVVAHLQHVLDDDELELVFVSTINDTHYEYTKAILNAGKHVVCEKPLTPTSAEAYELAELASQKNLVLAVYQNRRWDSDFLTLKQVLAENRLGEVSEFTSHFDRYKNEAATTKLWKEKDLPGKGAAYDLGSHLVDQILALFGKPQAVTGFVRNSRLIGNPDVPASFLIHLHYPSTSEAGRRLPLIATARGSVLSLVSPQMRFTVKGTKGAFIKHGLDVQEDQLKKGAKSAVDQADFGVEPKELQGTLYEVEGPHKIETKTGNYKAWFENVAEVSILFPIFAPCHELTKEPDTPSTQAIRSKDRSKLIVTPEAAALTIEIIEKATQSSKEGRTIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MCN0</accession>
    <name>A0A2X0MCN0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C008g05316 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C008g05316</name>
        <name evidence="2" type="ORF">BQ5605_C008G05316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY80163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MCN0"/>
    <dbReference type="STRING" id="796604.A0A2X0MCN0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="601"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY80163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="625" mass="67795" checksum="968B35E7F6D65D90" modified="2018-09-12" version="1">MDRASGPVAHNPASNSGHSSDQPPPPSYASLVAPVPGSPSSPSLGTANATAQSSISAHSIFPNHAAFDHSQAALGFPSGYFILRNRGAGGRVLDLLGHKTNEGALIGLHPLKQPQVDVDQLQCRANNQLWFIGWDGLLYNGALTLAYPHPVMSIPSHRSHPNPQFVFDPVTSTLRVQYATDPTFPGPRCEDRSDWNDYDYIVESVPQRRKRPNEQGLWDVVSSGPGNLFEGLSEKIFGTKSPSSEASNPLAGPGPSSPVRPPSTTSQAPIRPAYEPYRRRSSSNTNTNPPLLPARLRTVEDDSDSDSEPSASRSVRVVAVPRALRYGTPSQSEPSTKPKPGRSYQGGLDPSHAAGDVSQSSGQTLEIFRRERAREARRSKRRQWELISVVVRPVPTESYSRRNSFSETERAMAGSPSPSSVMRRVSSTVGLSSTPRFIPLPTSPSLDRTEPVRTRRAVSNAQQPTQSSIPVSSSLNSIASPGFSLPRILKANIYGKYPDESEASGDTTNTEGPDLFDDEPEDARVLQLDEIGQEMARSTSNLSSSERIGSERQRAGRMVEGLQVEQQVEATSSSLRAMQMDRPLPKFPSMEGLSVLATDTKEEEAAHTEVIDAKAAEEPRERIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MCP5</accession>
    <name>A0A2X0MCP5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C004g02697 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C004g02697</name>
        <name evidence="8" type="ORF">BQ5605_C004G02697</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nitroreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY66703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MCP5"/>
    <dbReference type="STRING" id="796604.A0A2X0MCP5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02140">
        <property type="entry name" value="Frm2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.109.10:FF:000001">
        <property type="entry name" value="Nitroreductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="entry name" value="NADH Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033877">
        <property type="entry name" value="Frm2/Hbn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43035">
        <property type="entry name" value="FATTY ACID REPRESSION MUTANT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43035:SF1">
        <property type="entry name" value="FATTY ACID REPRESSION MUTANT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="FMN-dependent nitroreductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="7">
        <location>
            <begin position="10"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY66703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="200" mass="22278" checksum="D8D6B45385A14316" modified="2018-09-12" version="1">MSSKFISSLTARRTVYALSASSPVPNSKIVEILNEVVKHSPTSFNSQSSRAVVVFGDEHKKVWQFTKKALKAIVPAEAWPQSEQRLSGFENAHGTVLLYEDKNVVKSLQENMPMYADKFPQWADHAHGILASNLWVALELEGLGANLQHYNPLLDTDVQKEFDIPEGWELKAQLVFGKVEAPAGEKTFQPLESRVKVFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MDB5</accession>
    <name>A0A2X0MDB5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C005g03201 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C005g03201</name>
        <name evidence="1" type="ORF">BQ5605_C005G03201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY72725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MDB5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY72725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="143" mass="15959" checksum="C182D785BAF198DD" modified="2018-09-12" version="1">MLPIEVELESDRKLTRDELVEKEEEVLPWVKEDGLVAKGFHAARSIAQEHFTYFKVLPSLTPAARAHFPEFHSLYPSGLDGGFYVFVWEEVGKVVSEAGCNLEMELNDKISGAFETIAENGIHHEDEEAPERGGPSRSANLCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MDD1</accession>
    <name>A0A2X0MDD1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C009g05424 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C009g05424</name>
        <name evidence="1" type="ORF">BQ5605_C009G05424</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY80967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MDD1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY80967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="33" mass="3599" checksum="A31F4AECBF5F1035" modified="2018-09-12" version="1">MTKHATVRISLHKCLKPSPATSDMQAVSAMNIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MFB9</accession>
    <name>A0A2X0MFB9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C037g11646 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C037g11646</name>
        <name evidence="7" type="ORF">BQ5605_C037G11646</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000062">
        <property type="protein sequence ID" value="SGY94372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MFB9"/>
    <dbReference type="STRING" id="796604.A0A2X0MFB9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015033">
        <property type="entry name" value="HBS1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08938">
        <property type="entry name" value="HBS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HBS1-like protein N-terminal" evidence="6">
        <location>
            <begin position="17"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="131"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY94372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="164" mass="18515" checksum="F1E88AEFFD1D238D" modified="2018-09-12" version="1">MQSRHRAVKQLDLAEQLDDDAIDSEGDDAYDMDDEQYAHMESGLSAVQNLLGPNTPISDKEIRDSLWDSYFDIDGTVAYLLGEREHRAIAPRNTKVFFPQHRFLFSADAQHKREAAKARAEGELTSAMAVETAEPPTSSLANLDISSSFIPPTRARRQRRRNRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MG13</accession>
    <name>A0A2X0MG13_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C014g07707 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C014g07707</name>
        <name evidence="3" type="ORF">BQ5605_C014G07707</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY19622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MG13"/>
    <dbReference type="STRING" id="796604.A0A2X0MG13"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="474"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY19622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="679" mass="75857" checksum="D58224FEB56EE813" modified="2018-09-12" version="1">MDRLDPMAIAVPSQDARTSPSRATRSRGRDPKQRATDADAQRRAPRPSGIDARAHQRCINHDKTRPGRTSRARGAVDLSGMSDLVDALPRSIPMKSSPVVSMTATAEAREQQLFAYIGKPRLSEAMDKYFLDTPSKHEANILQPTKKLGTEAAMKEIANAFKDVTGDRRLVVDNHINLAPDCEEQKRPDAVILTHAAVTASPDLSFVWAQSEDPTLVEGTPPSPQRAYSQIAVAIEVKESNTKSAEARNQVLRRLHMICTTALRAHAIGVTLCGDVLQVYLCGQEAVLLRRVLSHLIELDDNGLGMLASTNEVDDGFGNFVVSDKFLPPRAHDFEHAPVDPTSITSPTPAAEYAMTVAWVEQSRLDDAIALRRKMHAASRIDTEGLSLSAGIYRDDFRTLPTFFGDDESFDDIEPRALEVVFHRQCYQPLNTATTTKELAQAVLGVVKGEHEDQLGSLAFALPSRHARSHDNAGHRNLYKLGYIHRDISYSNVVIDRDSFGVLIDYHLAVPHDRPYTELHHRMRFGTWPYLACSILAQPEQPLGVVHERWHDIESLFYVVMESLFREPYQGDEEVLVMTPKGETIWRRWKSPDADLVYALKLTLRMDMIYESSLDGCAHRFPSIQLILSILRRNCGLDSRFLGLEVAEEEAQLGELWGPSKAMSHESIISDIEQLLPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHL5</accession>
    <name>A0A2X0MHL5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C009g05783 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C009g05783</name>
        <name evidence="2" type="ORF">BQ5605_C009G05783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY85848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHL5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY85848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="325" mass="36258" checksum="659B1FBB6A4DC9B2" modified="2018-09-12" version="1">MFAPTGKRVLSSATTPWLTTRAPLLPSCPYSSARPSHPSLQRVFSTTVPYRNAPNPHLTALLRLGPKPTPSSTAPSVRRVRSPYKLSMYSTPNHTMITLSTQASTISQFLDRSHEPTREEVNQSLTVLTLTTRMHATSRLPKGSRKSDLGRKLGPEGVGEQAQEITVLMLHKIKSMLKVEVQEVQEKKPDPTGELAAAWGLDPRIIGSTRYPWPRPTSIKMEYRGKGPGKKAFYAVFSGPEGQGLRELVEGVEDDLPKGEKGLFPKKRIDLLREQEARRIKEQKEDDEAMAMAMAMEKNSNRVDREESRTKEGSMGRSERSGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJK6</accession>
    <name>A0A2X0MJK6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="22">BQ5605_C029g10736 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">BQ5605_C029g10736</name>
        <name evidence="22" type="ORF">BQ5605_C029G10736</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ16176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0229">DNA integration</keyword>
    <keyword evidence="15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="12" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="16" id="KW-0862">Zinc</keyword>
    <keyword evidence="16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="20">
        <location>
            <begin position="422"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="21">
        <location>
            <begin position="1579"/>
            <end position="1751"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="19">
        <location>
            <begin position="1894"/>
            <end position="1955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="483"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1292"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="42"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="484"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="512"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="SGZ16176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1957" mass="217394" checksum="3F13D81A37F14C19" modified="2018-09-12" version="1">MAEPTDTSRDTTAPVREDPSRANPPKSPPTHSPHPLQAAAVITSLESRLAESEALRRDSETRIRKLEQMVERLMRESTAPAGAQVGEALPVRPVPLDVPPHTFLGRPGAAADPLARTPGGESHSGIRDGPSSAVISSRWRGTLPDREGLWTGDHPERLVIFTAFGESYLSLLCDISTSDLFDTSRVIQLVATLFSRTTTRQRRQSPLDWAVEAMRDALGEGRPHCWTSLMKAVGRRWPDPGFADRVAQDFHGCRQSSSRAYDHVGEWRARYRAFVHDNDSFTLSPLQLATTFYQSLSDSSKREVRAGMLREYHDNSLVTIGRFGLKVPSIDEITEWAAIADDISPPPSVPTPPSRTATYGAIVKAPRVSPPATNTPTVDERFQIRRARWVDRATKWQQSHLWKDRSTWFSPAPSGVPTSMACFNCGRGGHFSQHCTAERQSPVAVQLSAVAVADLDDEDWSSVAGGDEDPEVRVPISLERVQTRPLSSVSASMTRPSCPPADPVGRMKEGASSSVDVEVSSSNPQPTAPASDADLRRLADDSTDSAFDAVEDVPSYADAASRMRRYWGPEVVSSRKAERTASVSSVRVPVPLGVSLLESDTPLIDVDDFARPAEPAIVRARNIIAWTLPSGRTLRCLVDSGSEVDLVDQDVVRTDPSFTTSRLTAPLHLRLGTRDKSDRCAVFANALFTSGSLDLGLRAFFICRVTAYDAILGLPFLKDTGMLVGWGVFTVARPGPSQPVAKGTHEWDRAVTVAPICSGSAIGYDHPGLLPDDEIIGLEPHNPLLDVVDDPALEDLSESEARTRLAALLEKYSDVFVDSLPMDRLPPYRPVNHEIPLIDPNEKVKPRVYPLADKYRSQWAEHSAKYTRGRFWVSGPIDSAAPVFAIPKKNSQTARFVIDLRARNSNTAKRFSPIPDMTSVRYEVARSRYRSKFDVAAAFEQVRVIPEHVDRTGFATVTGTYTSRVMQFGDTNAPNTLNLLTSAMFQPCLSFAKIFFDDVHVHSDTRRAHLRHIEILLMTLRHYRFYLGSNKSEWFSKSLDSLGAIISDDGIEVDPAKWERIRQWPTPHNKTDVQRFLGTVNWMRDHLPHLSITLEPITALLAQSTSWRWNEHEQQAFDTVKSLVPATLRPIDGAKVTSGEHKIYLFTDASRVGIGACLASGPTRSQAVPTRFFSAKFNGAQLNYHVTDKEFLAVVSACRAFEQHLIGYPFVIVTDHQALRTIKTQKLRQTPRHIRMCLELSRFDFEFEFIAGKNNSLADSLSRLWEVKEGSPEDQVKENELEDMFFDGERHGFTTHGESLPEERPYTSPSPDRLPPVDFAFGPQRDDCEAGSPGYYALKDESQDEDVNGRDLGNLFLKEECHEFTTPGSPGSHRLAENIMDTVDSSTGPLSPPIAVNRVQAIAAAPANDAPIPVDADADELDLLGAAADEVNDAPVVHRPPDPLPQPFLDAVIRAYAHDSQAQVIVDDPLSWPMFRVTEEGRILRVHPDESLSLFVPRGLATGVVDSDKVPSLRELVLAEIHRSVGHAGHRITLAAIRPLYWWSSMSADCAKFCHSCEDCARGKASTQVPYGRLHPMPIPSGPWEQVAIDFMTGLPPVEFEGMMVAHIMVVTDTWGKMVHLIPLPADADSELVADRYYATIFRLHGTPSAIVSDRDPKFTSQFWRALQAKVGTVLRMSTAAHPETDGSSENRIKMVTQTLRIMVSSNHEAWASRLVEAEFALNSSVAVSTSLSAFEATYGYLPRRWPTDSWSVSDVPRAEAFARIRQLRNLDVTDAIIGARLDQTHQANKHRRPDDPAFRTGSYVYLSTKNLAVPEGMKSKLLPRYIGPFRIRAAIPATSSYDLELPPAMSRVHSRFHARLLRPYVENDAERFPGRDPAVLFVEDVADAADNSAIPERIVRDRRNARGNRSFLVRWIGRKDIDDTWMSEQSLRFDHPSLLDTYLAQLDRSNRRLSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJW7</accession>
    <name>A0A2X0MJW7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C032g11031 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C032g11031</name>
        <name evidence="25" type="ORF">BQ5605_C032G11031</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000067">
        <property type="protein sequence ID" value="SGZ03926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="490"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="772"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="826"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="863"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGZ03926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1444" mass="157573" checksum="536FEC93D4FECD1E" modified="2018-09-12" version="1">MSDAGASAPEAKLREPTPDAPPLRPPTHSAAFATTELLRNSSGYRDWVLAIRSRLPSGVVRYLNTGVPLESWPASYVPLWDHYACSSICASVNSQTVLPGLSPYLDESLAAPKVWQALCERYGTVSAVDLLPVIQRLFSSDPVPVTPDLFLQFRDSFENDARLLQDSQVTVNALLASHLLARLPSSFDAWRTTFVADQGDSTAMPSATEIFTRLYRDVKARPVDTPVAAVATPQARHGCSRPCPNPSCRKLHWLRECPDTAWAAAYRARRTAEKKASQPVASPAAVDTPNSVSFTACLLATPSPFRKSAWLLDSGANRHMTNDRGLFSELRTVAGPRVGGVAGSLPSTGCGTICIQTSTGPITVSNVLLVPDLPCNLLSVFQLDQLGYRVSFASRCASIARPSGAVVATAQAIGNNLYALALGPTPCTPKALLAIPTKVSLLTLHRRLAHLPVAQIKNIVQKGLVTGVDWVYKDQELRDFYCNACLASKAHALPFARSKSIASGRLDLLHVDVVQMPRPTFGGHRYMLVIIDDFSRKHWCILLALKSDVFPRLRDWILEVENATGNKVKTIRSDNGGEFTLRNFVDFCASKGIRRELTIPYTPQQNGCVERSNRTIKEGILALLYSSGADSRLWGEAALYYVHCKNLMPHAGIGGEIPDTRWHGFAPDISTLRAFGCRAWHHLPSAKRTDLDPKAVPLLFVGFDQHAKAFRLFEPSTRRIQLSRNVVFRESEFPALRPATDVRAEPIPLPVTVDAYPDQVDPLEPSLVASSRSLAPRAEPPRPVPAAPDQGPHRPAPAREVPDQDSLAPPAPDQGSPARELPDPESPASSASDQGSSDSAISTPCPSPRPVASRALPAPPSPARSDSPDPIDLLPRPRDVASLCQAQEFPDDVDDALHSPSAVAYLASGAAALIETSPADPAELIAPARDPPHWRAAMATPQADEWRLAARDEFDSLLQDFSAFTPIDESLVPADAKVLGSRFVFRTKRDQHGQVKSYKGRLVARGDSQRSGIDFDETFAPVAKFTSIRALLALAAAHGYHVHQADIDKAYLHGKLDAPLYIRVPDGIYMPGKVLQLHRSLYGLRQAGRIWNDEIDSALSALGYVATESDHCVYVRTTGDVRHYIALYVDNLLMISPSLPEIERTLQGLEQRYGVKRLGEAEYVLGIQIRRSPDGSISLSQEQYLKDVLARFGMSDAHPVATPMQPNLRLEVELQPTPFPDRTRYLQAIGSLMYASTGTRPDLAYTVSYLARFSHSPSAAAWGAVKHAFCYLAGTLSHGLRYARGNPAPLLGYSDCNWGACVLSSKSTMGYTFVYAGAAVSWSSRLQSRVADSTCDAEYLALSHAGKEAIFLRQLFGELGLSSSKPVLIYGDNQGANALTKNPVFHARTRHIRLRKHFVRDMVSMGDIVVQYINTGEMTADIFTKALSRNLFARHRGRLGICAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKH4</accession>
    <name>A0A2X0MKH4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C034g11319 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C034g11319</name>
        <name evidence="2" type="ORF">BQ5605_C034G11319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000065">
        <property type="protein sequence ID" value="SGY99985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MKH4"/>
    <dbReference type="STRING" id="796604.A0A2X0MKH4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004860">
        <property type="term" value="F:protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009548">
        <property type="entry name" value="Prkrip1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13507">
        <property type="entry name" value="PRKR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13507:SF0">
        <property type="entry name" value="PRKR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06658">
        <property type="entry name" value="DUF1168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY99985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="266" mass="29100" checksum="19FA2FA975B5F2F8" modified="2018-09-12" version="1">MASPSRSTSTPSTTTITTTTTTTSIPSSKELRHATPAQLQAAALQRLLKDTSKPVHIPSAPKEGVKQLRAPREMMRNVQGSSAGAGSGEFELIFFCMFSSQHVYKESRRREYERLKLMDEEEAYNKAKKAALDRQATYESQAEAKTAKNRLKRQKKKHAQRTTSASGAGEKADQVEEEKDDGAILGDKKRKLGSSTAASGGAFTFKSAKERQDEDQDEDEEAGPKDDDTQRIETINTGAFVQDAITVPQVAPAIEAGVKIVDDDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLG7</accession>
    <name>A0A2X0MLG7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C023g09736 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C023g09736</name>
        <name evidence="2" type="ORF">BQ5605_C023G09736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ24647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MLG7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ24647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="53" mass="5409" checksum="D323E7D2A8130AD3" modified="2018-09-12" version="1">MQRDWLSRPGSTDTVASARSDGQRPGVAGLCAGYWLALCTPNGGDNSSVAPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLL0</accession>
    <name>A0A2X0MLL0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C024g09778 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C024g09778</name>
        <name evidence="3" type="ORF">BQ5605_C024G09778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ25830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MLL0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1268"/>
            <end position="1553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="651"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="711"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1847"/>
            <end position="1872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="713"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ25830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2091" mass="232354" checksum="39704830B67024E3" modified="2018-09-12" version="1">MQTGDPGSAPGARAPPPPASAPTSLPIAGTKETQATQVAGRTATYAAATNSSVVSNETPAQQQDRLARLQALPGILAAIQAVPGNRADRFVQAIFATPDFPSTVATALKFSALNATRNIINPFANALEVSLSHKSTGRASATDKGELVACVRTLLSPNTPICFDTGVPLSGDLEAFMPRITGLQHSSTFRTGVLHHRITVGFVSAEARDAALASAPMLVWNSANARFAKAHPFHRNMLEMRINVGVVRPPSKEQIVAAFQSIVQQLSTKGHSCQLVQVLRVIHVDTAKAYAHTVGDFSAFIHFDDASLFQHPTTTLKEILPSRMDLPTRGLDVTAVRHDYEKEAPCARCHFAGHVERCPLMQAANRKEAEDLARHAVMRGAGMVGGGEQTGVGRAATTTTNNIRPTANNNNTSEVVAPSRALGTDQLESRNRFAGLEVEGGQEDDIEEEVAGKEGEEKEQVEEGDEDTGAKADDEDSDSDGNAGAGIDKAGGDGKDDDKDNDEHDDKDEQDDSSEGSERRGDDVMKDGAEEEDEEMETEVEEEVEQEQGVQDDSIMIIDDGQTTITTVSRESTPRSPLWPPLSPETLAKSLREGAEWDRANAEAAARVQAENEAIINAQLDAEEPLVRHQFAEWGQEDGQLRFINIRGTGSRSNKKMKRSQTVADLSDPSDGPVDVKRVLNRVKGRAGKEVAGQGKRVTRSMSAAAAMQVEGAKAKAEKGKGVEEEKRWSDHEPEDNILPEFPLFEDNITTKSTWNVRRCMGIPEKRRDIYTYLSTFKASAILLQEHFIKPELWQCIKDEYEGKAFISKHCLTLIPADSPLIDAEILRTHSALDGRILVTSFRLRGDIRILEINNLYAPVDTKQRLTFFDKLHFHRTQSTHLRLLGGDLNDCPLPAIDRRNQGRHGHHWPILIGKLDSPYTDCIRFKHPLTPSFTRPNIVRKRPKSFSRLDYFLLQRTHQKRLVQASTIYDHPKDLSDHRPVSIVLVLSDERGDAAQPNNSLPTTSNQLHRINAATFKTAAFQGMLEGWLEGASGEEPVGELEVVLGNCEKEGRELARREHRERVERMAVLVGRVQDLEALPVMGDEETAEWTRTTEELRRAVNERARQLRIRAHVPEIAIEERLSRPVHAKLAARSSDSKITALRLPNGELTHDIDVALDHTQAHFQRLYDLEPRDRDHVERLRDDFLAPIRAARTCDDPSSDPLFLRRLSKAHIELLQQPITEDEVVAAIATTHPDRSPGPSGVPYELYHTAPRAWAKALSRAFNAMTERGSLSPRQGQGLVRLLFKHHKIGADRAELSSYRPITLRECDYKLFTKVYVARLNHVLPDLLPPQQHGFVKGRRSADASFHLRLLIEELGARGTEFPDAALLSLDQSSAYDLVEHEWIFAIFDALGAPAAFQRVLRMLYSGDSTSARYIINGFLTAPVRLTCGLGQGDPASSSVWDVVFQPFLDALHRRGIALNLSLPTIHPYPQSRAITSLAFADDVVVAVAGSESLTLLDDLALDWRLATNGRLNTDKTVVLPIGCRWEAGDRPLVVKAEGESLEWIGLSFDPTGNTELANVNLVARLEAVLDSARDRGLTHHTRAFYVNRYAIPKILHILSADIPPLEVVKELDRILVDFVRGGKRRSCYGKDVVFTPRFKGGLGVMRMQDVVDSVAARVWDVLLGGSDAIWQGLARAAIVRAHPAPDFDLATDAWPCDYTPIRTDLHPRWQAVLKVPSTHNAQVKPRTLTLANLLALPIKLHTLHYLPGAPAVSRPPYDADYAAFAIYAKVADLFRRELYPGGGFHLWTPPTDVVVSNSEYDQRGRPQREHIVAWYRHAINRLRFTPIAQPVAAVRINGPPRVRPRSEVRPTTPLESILPHPIDPPQRLPRPALPDQSTQYNLLSMDRPYTIRRVRRVLNAKAFTDTIGFRDSLQPDDIKGFWKGVNSKALTAREREVWFKLVRNFTPTRSLQFHQKHDDSPACLVCGAPKDVREHYFFDCVDSGNVWIAARSVLCDALGLDTIDNTHYTAVQRMFGLPKLKASLRDREGAGRTIEIFTGLILEMISSGRWGMQKWGTRMEGVWRRRIILEERLKLRAGGAWGRRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MN24</accession>
    <name>A0A2X0MN24_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C020g09146 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C020g09146</name>
        <name evidence="1" type="ORF">BQ5605_C020G09146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000082">
        <property type="protein sequence ID" value="SGZ17833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MN24"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ17833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="932" mass="104970" checksum="497FAA6B977FD48B" modified="2018-09-12" version="1">MYNMTRQASKIWEVLGSRPSLQKFVDLGLKPVRIPCCVKTCVAFTGPREALTRCPVCNSPKLDQNGHPQNTFLYLSPDVYLNIYLRDRVYASLSLYEHFLQYSLMRYRSDFERNRDPQEVVDLFDGDRYREKLDQNISWTNPPIAGASQPTVSTINVKYYENDVDVAFGLFTDGIQLFNKTQSECWPIMMINNNLPPEIRYKKKHLMTVGIIPGPKGPKDIDSFLHPLYEDARASARNGHMVFDGVTETMVRQRWFIHVIGGDGPALSKMLGFKGPIAKWPCRVCLIQGVPCAAAHNHNYYPLKMPLDSSHANRSDLTALDLPMRSEATIREAASEKNPTFGLSKLSSAAHLPGFSLHQDGPSDFMHAVFENVARKLFNMWHGDLAAQKSKGYKTQAAQAQRGRSAQGKVTSAASAEATTSAAAVDEALGTDLPDWVIPNKIWEVIGQEITNGAKTIPSLFARKMPNIHLQTGAMTAEDWSNWILYVGPCVLHDRLPAKYFAHFLALRRWVKDCMAMTINKEDVAKDGALRRDIASWCTEFESLYYSGKSAQLINLPHSVHAVLHIADFIEWHGPPAMTWCFAMERLNQTVKRVASKAHRLPYEAVNRYVCADAALQMACSRFPRFSYPITVPALMKHQQDKQMELEQMQQSRGLFMNATGDQMRGSSVAASRQVSSENGDSGAEALGLYGRRSDKLKQGPGINDVMRVAQFIARELFGQLAPVVFKRKVDAIRTSILSLSINFFEGYRMDSGRDRMAAAERLSKHARVSADTRDASWISYDLLIDSSRRRARDNSQAFPREGKGADRVKHFGQLLAIYEFRYGEQNFLLGKVRSLGLSHLQPVDTVERAPIAKPTPKRQKRKALSVVGGHKHQNLFFTQGKRASGAVEIVDLRCILGSAGRIHRRVGREESREYIFDRMDDEARPNFLNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNE0</accession>
    <name>A0A2X0MNE0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C022g09500 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C022g09500</name>
        <name evidence="6" type="ORF">BQ5605_C022G09500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MNE0"/>
    <dbReference type="STRING" id="796604.A0A2X0MNE0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3250:FF:000001">
        <property type="entry name" value="60S ribosomal protein L13a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1180.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_uL13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005755">
        <property type="entry name" value="Ribosomal_uL13_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01077">
        <property type="entry name" value="L13_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGZ22520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="200" mass="22514" checksum="642CD0F01E3C5D94" modified="2018-09-12" version="1">MATISAAPIVIDGKGHLLGRLASIVAKQILTGQKVVVVRAELINVSGSFFRAKLRYHEFLNKRHLVNPKKSGPFHHRAPSRIFYRTVRGMVPHKTARGAASLERLKIFEGVPPPYDRKKKMVVPSALRVLRLKPGRKYCTIKRLSHEVGWSYRDVVDRLEEKRKVKAAAFHERKVQGVKAKAEALKSAGSINEKLAVYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNE8</accession>
    <name>A0A2X0MNE8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C003g02297 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C003g02297</name>
        <name evidence="3" type="ORF">BQ5605_C003G02297</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MNE8"/>
    <dbReference type="STRING" id="796604.A0A2X0MNE8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF4">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY39937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="186" mass="19308" checksum="DA70CE629555CEEE" modified="2018-09-12" version="1">MANQVLEIPQSFPPGSFKGRIALITGGSSGIGLSTTQTLLSLGCNVVIGDLSPPPSSLSDVASKSGAKLTFQKCNVADYSSLLALFKHSKSHFRAYPSLVFANAGIAERGKLFTFDSPETDPSIEVEPDYSVIDIDLKAVVSTVRIGMWGIKQNSDEGAGPDVGKDASIVITASMAGYAGQGGLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPG7</accession>
    <name>A0A2X0MPG7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C022g09459 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C022g09459</name>
        <name evidence="1" type="ORF">BQ5605_C022G09459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MPG7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ22243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="55" mass="5872" checksum="46F65DBFAD5B6655" modified="2018-09-12" version="1">MYATPSVGTSPSSLFVSSYRVEVDHASPCPSTLCTTSEALVHRRLSFGGQAARRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPK2</accession>
    <name>A0A2X0MPK2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glycine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Diadenosine tetraphosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BQ5605_C022g09499</name>
        <name evidence="16" type="ORF">BQ5605_C022G09499</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 ATP + H(+) = P(1),P(4)-bis(5'-adenosyl) tetraphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:34935"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58141"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="4"/>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MPK2"/>
    <dbReference type="STRING" id="796604.A0A2X0MPK2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070150">
        <property type="term" value="P:mitochondrial glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00858">
        <property type="entry name" value="GlyRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.200:FF:000001">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000004">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000158">
        <property type="entry name" value="Glycyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000010">
        <property type="entry name" value="Glycyl-tRNA synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003211">
        <property type="entry name" value="PRK04173.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745:SF0">
        <property type="entry name" value="GLYCINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="GLYCYL-TRNA SYNTHETASE/DNA POLYMERASE SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="15">
        <location>
            <begin position="283"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="27"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SGZ22512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="720" mass="80787" checksum="BEB930A2590BB684" modified="2018-09-12" version="1">MPLLIRHLPFLQPTVFCTCQALQLPRAAPGNPPAPRRGPSPISSYSTRRSSPVKQPNSAQKMASVSHPDQVNKTTHPFERQAIETLLLRRFFFCPAFEIYGGVKGLYDYGPPGAALQANILDLWRKHFIIEEEMLEVDTTIMTLSDVLKTSGHVDRFTDWMVRDLKTNEVYRADHLVEGVLQARIKADAEARGHALKPVVEDPTQKKKKKVVQTVTQILPDGKAEEYGTVLAQIDNFGGKELSELIRKEGIMAPDTGNEVSEPVEFNLMFETQIGPTGQIHGYLRPETAQGHFVNFNRLLEFNNGRVPFASAQIGRSFRNEISPKQGLLRVREFTMAEIEHYVDPQDKAHDRFDSVKHVEMQFLPKGVQESGKTDLTTTTIGQAVEEGMVDNMTLGYFIARIYLFLTKIGIDPKRLRFRQHMANEMAHYAADCWDAEILNSYGWIECVGCADRSAYDLTVHANRTQQKMVVRKALDEVHVYDKLVINLEKKTFGPMFKKDAKALEEGLLKLTQEKTSEAQKALTEKGEYLFQGPNGQEFKIPSSVMSIKSVTVREQVREFVPNVIEPSFGIGRILYSLLEHSYWARAEDVNRGVLSLPPSVAPVKVLIVPLSNNAELKPLSKQVSNQLRSLGIASRVDDSGASIGKRYARNDELGTPYGVTIDFASVKNGTITLRERDTTFQVIGKVEQVVTLLVELCSGRLEWAEAATRLPAYTGEQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPP8</accession>
    <name>A0A2X0MPP8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C049g12447 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C049g12447</name>
        <name evidence="7" type="ORF">BQ5605_C049G12447</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000111">
        <property type="protein sequence ID" value="SGZ30730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MPP8"/>
    <dbReference type="STRING" id="796604.A0A2X0MPP8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007203">
        <property type="entry name" value="ORMDL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12665">
        <property type="entry name" value="ORMDL PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04061">
        <property type="entry name" value="ORMDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGZ30730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="283" mass="30194" checksum="CDCF73D5AD69CE66" modified="2018-09-12" version="1">MSANPALLSPTGRSSALPSQPPFRRARSASTGPPSASSSGAATALTIDTSGAAATSAASALGLGSSNPGSAASPMRRPRSASVLSVQEVPINYDDSLDQAALTNVNAEWVNYKETVVVIGAWLIHVIGIIAGIVILDIIPGTTPDLIWTIVNLGYLFISYIMFHYVQGVPFDMNNSGAYDSLTLWEQIDSGAQHTPAKKWLTTLPIALFLVSTHYTRYDSHPAFFTLNLVSLILVGLAPKLPMFHRLRFRFFDSGATPEPSAPATPNEDSITELGERSFGTFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MR49</accession>
    <name>A0A2X0MR49_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C027g10407 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C027g10407</name>
        <name evidence="3" type="ORF">BQ5605_C027G10407</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MR49"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="750"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="652"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="560"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ28676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1046" mass="115662" checksum="80397EA61B026A73" modified="2018-09-12" version="1">MSTGDPGSPPPAPPPPVSATSVQPPRDQIPISSKKTQATGPATAAPNYAAAASQATQSPEQQQQQQQRAKALGSLLQAMGAVPGNRMDRWVQAIYFAELYPVATATSLKFSALNANRSVENIFDYALEVTLFHQSASRASHADKTDLVACVTRLLSPISPICFEPGVPLPDHLAAYRPQILGVQHSSILRNGAAHHRVTVGFVTGEARDAALTTPPALTWRSAKARFAKSHRFHHNMVELRINVGVQGVPSMDAIIKSFQLLVQDLSGKGHSCQLVQVLRIISVDNASAFAHVAGDYSAFLHFDDDSLFKRPNTTLKEILPSRIGLPTQGIPVTALRHDYEKEAACGRCHFVGHVGTCGLDQESKRKEAHNGNGNANTNANKNTITNDTNIVEAEAPIPVPVVNRIASQNRFAGLEVEEGQEEAVTGQSGQGPEESGEEDAGDKADDEDLEDSEMESEATAKTEVIKLKSEDESVLEDCGGSDGEVIDEDEVMADRRGETEGKVATEMEEREVATEMEEEEVATEVDNVDEAGGATKAENAEATDLGETNRLDNDDDSDATATAATASRESTPHEPTPPLSPETLAKSLREGEEWDRIRANWVEQARLERDQSIERRLDAETPLVRHNFATWDEDGEIRSINIRGTAAKFKKPVMKRSQTAADLSDPSDEPTDAKRVIIKGKSRVVVKDGTEGRRVTRSMSAAAAMPVGVTKVDRGKAKGVAEEKRWSDHEPEDDRFDLNYPLMIKHTIITWNVRRGMGVPEKRRDIYNYLSLFKASAILIQEHFIRPHLWQLIKDEYEGKLFINQHCLTLIPADSPLIDAELLRTHSALDGRLLVTSFRLRGDIKILEINNVYAPVDPKQRAKFFDKLLFHKTQKSHLRLLGGDLNDCPRPEVDRRNQSRRGHHWPILIGKLDSAYTDCIRYKHPITPSFTRPNPNRKRPNSFSLLDYFLLQRTHQKRLDQASTIYDYPKELSDHRPVLIVLALSDDPDATLPQLSLPTTSNQLHRINTTTFKTVELMEGWLEGASGEEPVGELEVILKACRDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-07-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MR97</accession>
    <name>A0A2X0MR97_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C027g10305 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C027g10305</name>
        <name evidence="5" type="ORF">BQ5605_C027G10305</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MR97"/>
    <dbReference type="STRING" id="796604.A0A2X0MR97"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_7G04540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGZ28296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="304" mass="32960" checksum="837A2DFF1424E78B" modified="2018-09-12" version="1">MTTPTFAIPELFCVKGLVALITGGGTGIGLMCARALAENGAKVYIVGRRREVLEAAVEGFRKLRATSECGGGAMVPIVGDTSEKETIVRIMKEMEGREKWLDLLINNAGVSGPRCTVIDQEGAEAIGNAMFACDTEEAIKLFKINSLGYYYMSAAFLPMLNRSPNGGQIINITSNLSFGREPVAGVLYAMSKAATTHLTKLLATILKDTNVRCNEIAPGLFPSEMTEPLLDQRRSNVLQNSENVNGSERPINWLKPNAARTMQFGTPDDIASTVLYFASKRQRYLSGSVVMLDGGMLNRMPSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MRL9</accession>
    <name>A0A2X0MRL9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C026g10255 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C026g10255</name>
        <name evidence="2" type="ORF">BQ5605_C026G10255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ28026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MRL9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ28026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="95" mass="11372" checksum="532E4780AE9E1F6E" modified="2018-09-12" version="1">MDKHNLSSRDNLPPQARSPIDRLGESIHRGPIRRDLAKGRVGQRTVQFRNGTLSLKTFLLTTSLLILRSSRDRNVHRWWIHWMKLIFQQWKQCNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MRV2</accession>
    <name>A0A2X0MRV2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C055g12662 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C055g12662</name>
        <name evidence="3" type="ORF">BQ5605_C055G12662</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000092">
        <property type="protein sequence ID" value="SGZ29284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MRV2"/>
    <dbReference type="STRING" id="796604.A0A2X0MRV2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="275"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="512"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ29284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="737" mass="80764" checksum="F9031AE195BD5663" modified="2018-09-12" version="1">MRALLRIGPVDAPALGRARFVSARAVTATAPIGAWASGALASTSTSPSPSPSTSPSTSISAAANSAPTSSATANAYDLAELRDAVSPLVSSTQSTPLRSRREAASHERASDRAERISEAVQMDQKHCAALEAYFFGHPTAEELANKIWPKEFKMGTEEALGEVIAGVINTVNRRLVACQNSPQYISVAPDRVETTEKTADVVLLTHAAVAHDPTLPNVWALPSHADPAKKLDADAGPATNVNSNANENGKGQPHDEDNNAEEDSTNTAKVKDKDKVDLNQAKRSFTQVAAVGETKAGTSNAERQLFRRLSALLATPIREHAIGFTLRGERLKVYVMSACGVFSTKSRTVTEENGELSTFLYRLVQHSDRLNGILATTTSLDDRYGPFTLCPDFFPPAASEFSGGATTMSNVKIKELIFRRQRECGRATSTYEVTLAEGANIRTFAMTIIWVEESRNSDLAEIRNLIQEKRPRGLAPLVGVFRTEYRTLPMFLPGNESLAGCTPRAREVVIHEERYYPLATLKTTKQLACALEGAIEGHRQLWEHGFIHRDVSYGNVMVDQNGKGVLIDYNLAVKKVRTVDEECRLSRSGTLPYISRLLLSPATEGVVHERWHDIESFLYVACRTAFQSESESADARLFEKPDAARIWNAWNAKDLKDAAIRKGWMSTRSGFRELLNACASRWSGVEKVLSVLQQNCSLELSFSALEDLETEPELASLWRSGQMSYEHVQAAFTALCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MRZ1</accession>
    <name>A0A2X0MRZ1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C018g08784 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C018g08784</name>
        <name evidence="1" type="ORF">BQ5605_C018G08784</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY26776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MRZ1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY26776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="100" mass="11406" checksum="1DBBBD25BA7A5E2F" modified="2018-09-12" version="1">MVKSKSPSAKNIWEKLKQHHEGNTDPFKIRTLLYEISNSSYNEDTNLGEFLQGITDKVDQLEDLGQKFKDEAIVAFMLQALPPSYEMLKQAIKLSDKCSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MRZ3</accession>
    <name>A0A2X0MRZ3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C027g10386 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C027g10386</name>
        <name evidence="8" type="ORF">BQ5605_C027G10386</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MRZ3"/>
    <dbReference type="STRING" id="796604.A0A2X0MRZ3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="7">
        <location>
            <begin position="190"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="44"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="345"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="360"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGZ28609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="379" mass="42384" checksum="B35D0876E8498B04" modified="2018-09-12" version="1">MKAAPPDTEIPYDGSESQYMLDLVSCLADSAICPVWQSPARNINGHSRGRRVSTERSSAPCPTYSSSASRSGSCNQSTFGHEASKALNRSFSPYTINLWGTFIITSVVYWIGGLIFMAFDLYEPLHNVLKPYKLQPDKRVSVADYKKVCWIVLRNQVLVALPMTWAMATYRPLSTTAPLPGAFETIYTYIFCTLCMEAGFFYVHRLFHHPKLYKHVHKLHHRESVGLMVQESVSHCGTEFTAPVALSSTYCTLPEHLFSNLLPIVLGIMILGAHWSLMIMFFCSLELGTLNTHSGYNFVGGFSALQHDWHHYAYTENFGPTGILDKIYGTNTAFTSWIEELTRRESGQTGSSKGDVVSQARKELARKEDAGETFVSSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MSA9</accession>
    <name>A0A2X0MSA9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C048g12351 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C048g12351</name>
        <name evidence="2" type="ORF">BQ5605_C048G12351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000110">
        <property type="protein sequence ID" value="SGZ30407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MSA9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ30407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="76" mass="8590" checksum="D04583356E468A92" modified="2018-09-12" version="1">MLGSISFSSVGGFLVLQISDEFHTKKKKKKKKKKKKKKKKKDKVVAPPSLPSALRAFERDFLSRAGFVPGARDWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MSD7</accession>
    <name>A0A2X0MSD7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g03818 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g03818</name>
        <name evidence="1" type="ORF">BQ5605_C006G03818</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY53926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MSD7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY53926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="193" mass="21168" checksum="E6C3263507EEE5B1" modified="2018-09-12" version="1">MGCRDGRLPTRALIASNAVLCSPVQPSSTCAPFRLPHCCRSGPLLDSLHFVGIHLDAFARDLVAEEEALGSEQFRLLWGHVQIGSSQRVQDQSYSSFVFLQCVGENCDVIEVHKAHVPDKVAERLVDSALMRCRPHGVITAVFGMSSSAILVWKKEFVMSIFPQNRAFEQIDRISSGSGNGVRSQTVPSLSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MSP3</accession>
    <name>A0A2X0MSP3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g03948 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g03948</name>
        <name evidence="2" type="ORF">BQ5605_C006G03948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY55014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MSP3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY55014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="195" mass="21475" checksum="FBEEAF0040ABD6C3" modified="2018-09-12" version="1">MIRERAGFLAVTSGDWLYEELVIDVLANIRSAWKLAYDREVCRLAGIKGQLSKVDIATLRSRHGEGPSRKDGVYSASDTGTSDLEEEEVLATRNRTLVPKKRGARQGAGSPQLSQETQQTSPHVGSSGQRSTPAASGVRGPGPPRNKKKTEHNPNRSQQTNPKRDLGNGRAEEEEDEDQGQDEEEVEELERSPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MT72</accession>
    <name>A0A2X0MT72_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C044g12171 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C044g12171</name>
        <name evidence="3" type="ORF">BQ5605_C044G12171</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000114">
        <property type="protein sequence ID" value="SGZ31425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MT72"/>
    <dbReference type="STRING" id="796604.A0A2X0MT72"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016049630" evidence="2">
        <location>
            <begin position="26"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ31425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="324" mass="33167" checksum="ACF7C17E1782181B" modified="2018-09-12" version="1">MRNTRSTPLMGLMALAFASPTLVAGQTNSQVNSLNDFCLFAPPRAGVAIGDSEAYEVAYCTAPNRGTRSMPAGTIKSAHFLETPHYTQITGTGDFTKIGGELDPHGATGQGNPVGGVVYSGGTQVYEWHEFISDTEFCIRVCKPSVPDAWLWCQHIYDLQGCGWNDPGQYGSGFDTCEGDGTDYPPGIYPVSGGRFTTYEQGDGSTPAPPAHAAGASSNCVAQNTINGNAGPVTFASAVSLLSGAVVTTSVATTAALSTTTTTSTTLAVVTVFSTASTASTSAIAATSSAAVRTTSGAVSMNPKVLLGVGASILSVLFTLAIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MUM6</accession>
    <name>A0A2X0MUM6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C031g10935 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">BQ5605_C075g12917 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C075g12917</name>
        <name evidence="1" type="synonym">BQ5605_C031g10935</name>
        <name evidence="1" type="ORF">BQ5605_C031G10935</name>
        <name evidence="2" type="ORF">BQ5605_C075G12917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000068">
        <property type="protein sequence ID" value="SGZ06354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000128">
        <property type="protein sequence ID" value="SGZ34771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MUM6"/>
    <dbReference type="STRING" id="796604.A0A2X0MUM6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ06354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ34771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="498" mass="55772" checksum="84B5BF71145D587C" modified="2018-09-12" version="1">MTKCSSWQSYLGQGCNKQRSSLPLAKLGMTWKEAVRSPVWNKKLWRRVRRWIPPPSILEPLVREVFEKFGPLIDAKSKQPLFNKAAHEAAKRCLEAIRKGQLYTDLGPCGGPDGKADDGVRLYSCQRDTNSLEGGIHRNLRQRFPKSGVSPSHVNACMADYVLVHNLTVSPTPLSQFEEAATILTHYPLYSQVGTFNRTGKPFVGHYDLWLNYISPTAQMRFLIEPYQVERGTLRLEPVKWSPRNLLQNNTPAIQHMQSRLPTDRKLRHDWLAERQGTRFAVLHVHTPSERALYRYLSSKVRLGAPQNLRILEITELWNKYANGVDIFYKMPEHINTWASRWSSLANAQATMNLGGNDVRVIQALLTDPSSGRDVSMLAAKPLLGHKPPVVGRLTEVEVDASDPPTSSIRPFVATASSDAGSSAHLGTRGYHKRGKALDDGSVTGCDGACLDCGKPFGLTDEMDPNDPQSRRFCRGLTRAEMNGRARHQKKCHSFVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MVZ9</accession>
    <name>A0A2X0MVZ9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C004g02812 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C004g02812</name>
        <name evidence="3" type="ORF">BQ5605_C004G02812</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY67829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MVZ9"/>
    <dbReference type="STRING" id="796604.A0A2X0MVZ9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTLH" evidence="2">
        <location>
            <begin position="65"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY67829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="291" mass="31768" checksum="9C85ABB6596CAD74" modified="2018-09-12" version="1">MAFSSSSKRLATTPEEWNNRLAAIDVSKDDLNSIISDYLFTEGYLDAAAHFSREANISPPIDLDSIESRMEIRRAVQRGDVREATELVNNLDPELLDTNPALHFHLLQLQLIELIRQGEIEEALTFAQSELAPRGEESPQFLKELERTMALLAFEMPSLLAATEPSTNLALAASAPRASSGGAGKKSRKSGAGGEGSGLTTEDTSIAMPSSISSLLDQSQRLETASELNAAILTSQSHSKDPKLPGLMKMLVWGETLLNERNVDYPKWSFHDLLREQGEGAEGRDADAMDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MWL5</accession>
    <name>A0A2X0MWL5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C001g00044 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C001g00044</name>
        <name evidence="8" type="ORF">BQ5605_C001G00044</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY43664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MWL5"/>
    <dbReference type="STRING" id="796604.A0A2X0MWL5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="7">
        <location>
            <begin position="282"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="20"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY43664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="430" mass="49677" checksum="09E875D45FA0B312" modified="2018-09-12" version="1">MNVLQAASLNVHEVSESSSAIGGAQAPSASAVQSGNPLALSRRADRESSTDSSSSEEFISYGDKTAAEEPVIAGNIIHGVRTTRQKVDRRPLSDWHLKPFREMTWAERLCKLAAAPEQVHELVPETVDRGPMPTNPWWNDNIFIISRAMIAPVIQRTTQSYFNITWNPVAAYFFYVFIFIEFSRMVLDRLNGFSIRFGSLDEKNCGRDRTPNASVNNLALGVVCESQQSGSKNIDFGRSCRPLLPAAYMFIRPLFTFLLAYDKTQQPLDIIRWSYPLRLMAWQLTLDYLFYCYHRLTHEVDGLWWVHKHHHSTRHPTAILSILAEDYQEVLEIFVLPFLTSLLWRQTFTEQWITLCYTLMVEMQGHSGVRMLWHHPTLFWLKYFNCGLVLEDHDLHHRMGRSGRNYGKQSRVWDRLFGTSTERIETYGMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N4B3</accession>
    <name>A0A2X0N4B3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C005g03296 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C005g03296</name>
        <name evidence="7" type="ORF">BQ5605_C005G03296</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP12 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY73477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N4B3"/>
    <dbReference type="STRING" id="796604.A0A2X0N4B3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3580.10">
        <property type="entry name" value="ATP12 ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2180.10">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011419">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042272">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023335">
        <property type="entry name" value="ATP12_ortho_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013:SF10">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2/ATP12 PROTEIN, MITOCHONDRIAL PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07542">
        <property type="entry name" value="ATP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160909">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY73477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="334" mass="36952" checksum="B4DB1CDF9BD30C33" modified="2018-09-12" version="1">MFRSTARSFVRTTASTSTPTAATPSRIFVRSAGSLQTQHVRGPFAADADADAAATAPGNPAEPQTSRAEKMMRRFWKTVSVLPQPDSQPIRNLLKPLGFLTQRLRLAPRLTGTYAVMLDKRTLKTPGGTKISLPKQQLAVAVLIAEEWENQLAVLKPHTLPMTSIISRAIDGLSTPDVRAEVVANLLRYLDTDTVCFHEEEPDHLVTLQDAHWNPLLDWVRKTYDVELIKYEGILNTKQPDPTIVKLGGVVADYDEYKLAAFERAVLASKSYLIALGLVEGHLSVDEAAKCAHVEVQSQINRWGEVEDTHDVDHQDVRVRLGSAALLCSAMKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N545</accession>
    <name>A0A2X0N545_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endopeptidase S2P</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C005g03596</name>
        <name evidence="8" type="ORF">BQ5605_C005G03596</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N545"/>
    <dbReference type="STRING" id="796604.A0A2X0N545"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031293">
        <property type="term" value="P:membrane protein intracellular domain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905897">
        <property type="term" value="P:regulation of response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001193">
        <property type="entry name" value="MBTPS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13325:SF3">
        <property type="entry name" value="MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE-2 PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13325">
        <property type="entry name" value="PROTEASE M50 MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE 2 PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="489"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="582"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M50" evidence="7">
        <location>
            <begin position="162"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY77287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="602" mass="66096" checksum="AFB5E0E37676DA12" modified="2018-09-12" version="1">MPVPTSLLLAFATFWVVINYVRLTRRPRSASASSAVELQPLSLHASTTTFNDVPRLLLKTFRRRPEGGSRVLALYWDLATLVVVFGLVVVQLVLATAACKGVYALLQLYATSQPDPITSLGVVQGLIKRATQQLQPPPSESLLLQPIIPGLTHSYDSLPLVLVALFSSQVFHELGHALAAASESIPLLSIGFRLNLIVPTFYVELPSSTTSHSSVTSSTTDLRIAAAGVWHNLLLVGITWLISFNGLGWGSLFTRVFYESVEGGVLVTEVDLVGLFFFSGHLSNRPVPGHPDLSFLPSGQTSPLYELLQPRIKITHLDDLELDSSSSPSALWADYLSSEPSTSTSSSYNSLGWCLDATLFNPSDQALPSCCTPASTQTDQLCFQHGASAVSYACLEPSSIFSPPSKKQGPTRCLDDRGCSLTAQKCTSLESDQHILRIGVEDTLSPDGITKILIYQGPRMAVLHQVSVTTDLPRTRLIPLLYLRTIERFYSHLLGLSLALAFFNLLPLPYLDGQVLWSTVWTLMRGFEEVGDRMEVGEMGKKEGVMRGRGILDRSIEGMRKFGWLRKLAEREERVERLLRRWTMVMGGLTMGTGVWVVFIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N5Q6</accession>
    <name>A0A2X0N5Q6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C008g04977 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C008g04977</name>
        <name evidence="2" type="ORF">BQ5605_C008G04977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY78867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N5Q6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013640">
        <property type="entry name" value="Vfa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28218">
        <property type="entry name" value="VPS4-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28218:SF1">
        <property type="entry name" value="VPS4-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08432">
        <property type="entry name" value="Vfa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY78867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="212" mass="22258" checksum="18E38D8312DA7AB9" modified="2018-09-12" version="1">MAATRPGPPQLTNLYHLRTVGTEKTCSMCSKATFACLATPDVGDFIYVCTSHLADPGFAKPATSSNTPSTPSSISSPAPPSPANLQSEIEKVKAEYEAKLAAKDKTLADAAVAKSSSSSSWLHSGLKTGYSAVSSLATTTMATITTPLAPPPAPVPSPHEVNKAIALNSKVFTLHRSIFAMRQDAVKKKWQAQDARERAKGLGLPSVPISRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N7Q3</accession>
    <name>A0A2X0N7Q3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C009g05728 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C009g05728</name>
        <name evidence="3" type="ORF">BQ5605_C009G05728</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY84945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N7Q3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="63"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY84945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="309" mass="33601" checksum="73098EA270CF250E" modified="2018-09-12" version="1">MVSTTTIRRSNIGASSQASTSASTSDFPAASSPASQATSAVTSHQPRAITEDRESIDQERARASGTASSSTSRANGRVEPTPTTTSILTSTSSGIFPATPNATRFAPSQQPPSSKALGKRRQSSPDASSLPSPTSLSLSLGTSTSQPPRPDRKGGRKRIKPSRDQTHSINGPKLAPGAGIRSKKRNVVLAEEQASKDGSKPSAMVLKDRRKEFLKKIREAKGVEEEEKEEENWSVEKIRSVKASLLEQIQTELDQIQQEYKILTDELVKAQIEESVWNNVKKETLAERTHLRYLNKGQLMNLLTNPRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NBH4</accession>
    <name>A0A2X0NBH4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C028g10536 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C028g10536</name>
        <name evidence="2" type="ORF">BQ5605_C028G10536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000080">
        <property type="protein sequence ID" value="SGZ12939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NBH4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ12939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="63" mass="6956" checksum="0E09CAE14DC8D5BF" modified="2018-09-12" version="1">MAYHNWGKGLASCATPRRSSKRSEGRTVLLQRCGSRVVSRKYSTLGCRLQSQVGPPPAPRIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NLJ0</accession>
    <name>A0A2X0NLJ0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C011g06504</name>
        <name evidence="14" type="ORF">BQ5605_C011G06504</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000007">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="12">
        <location>
            <begin position="594"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="13">
        <location>
            <begin position="1136"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="11">
        <location>
            <begin position="1448"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGY12429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2012" mass="224907" checksum="FDBEBCC3FB6D85B2" modified="2018-09-12" version="1">MPTPTAPSHSPTYKPNDPPQLHSTLMEALREYFMRLDFYNRRIARTPITSDYDKIEGAGMGLQVFALKTWFTQGLSKHLAKPYAQFKSELICRAVPADFVWTQLAELHRLRQAPGHNIDAFQEFSDQMRSLQMEIGFQVVSDQEVAKLVLLGTDPELCRILRTHMVSSLAGWSDLSLEKLALDAPVVPTSPEAAEVFSDAHTDQPLEFDYQVFERIGREEWSVIAQRRQAIATQVGALQQRPTYSRPAAASAAPHVATAATGHSPITGGPRPVARLTVDERAYLDQNHGCYRCRTLNADHISRNCPRYLSPMGASATPSTPTSTAPAPRPGPRMVAAIRTFQETGDSTVFAGLSSDSEDDNDPSYAPHPFPPLPVSLAGVHGTLLASALVDSGSPQTFLSEELVQRLGLERRALEQHSKYTLAMQNQVPTVFTCTHFVRVPLELANGLWAAGPTYAEVAPLGKDLAIILGGNFIYRHKMELGLFPQPHLTCKANPIHAIDLLVLSSQPCAAARVAAIAPVSDDEEQLRLAALDHRLRAEFADRFPADIPPVHLYQSPVRHRIELDTPSTVVNLRGYPLPKKYREAWYLLLQEHLAAGRLRPSRSAYSSPSFIIPKKGCDVDPTIAPRWVNDYRELNKHTIKDRTPLPLPDDILSTCSNAQFWAKIDMTNSFFQTKMAEEDIHKTAVSTPWGLYEWTVMPMGLCNAPATHQRCVNEALQGLLGTICFVYLDDITIFADTLEEHEARVCQVLDALRRAELYCSPTKTNLATAECSFLGHIINRAGVHTDPKKIQRIEYWSLPKTVKELRGFLGLVQYLRKFIPGLAEHTAALTPLTRQGLSSIATLWTPNEVRHFKAIKAIVTSLDCLRPPDHSANAAPFWVMTDASNQGIGGVLLQGQEWKVARPIAYWSRQYIPAERNYPTHEQELLAIVEALKEWRIDLLGGHFHILTDHSTLEHFQTQRTVLSRRQARWLDTLAEFDYDLRYLPGEDNIVADAMSRYSFTDPLPTLVAAVSHVKLSDAVKQQILDAYKTDPFCQQAMSNIGSVTSDFKIVDALLYLRGRLIIPSLAPLRESILHDAHDAQGHLGDMKTYRTVQQAYFWPNMSRDVKHYVQQCDSCQRTKACTTRIAGKLHSLPVPMRPMADIAINFIGPLPANKGFDRVLTITDRLLGYIRLLPAREADTAAEVAARFHEGWHRLFGLPQSIVSDRDKLFTSKFWTALHKRLNIKLQLSSAFHPETDGRSEKTNKTAFQILRALVNKEQSNWAECLAVCEYAINSSLNVATGKTPFELVLGYTPSLAPLARVDGDDDLPSVEELLALRFQACEDARDQLAISKVRQAAQSNKKRQDKPFWAVGDLVLLDSSDRQKRLHTRKRRAAKLMDCFDGPYRIVKAQPEISSHTLQLNGDDAAVPFFHTGKLKTCRKNDTALFPNREPARLGPVDVGGEPEYIIEDIVDERIRAGKQQYLVSWLSWPSDSNSWEPAEALEDTEALDRWERRNEEAISCLSHNLSVVRDPANWGDVIRSGQQDTWGGPAHDKFNSLLNKYEVFEVIDSCELPRHGDIIDRKARLVAHGCAQRPGIDFEQNYAPVVKFMSIRALIALVAANGYHVHQANVNKAYLHGKLDKPLYMRVPQGIDRPGKILRLSKSIYRLCQAGTIWNAEIDSTLRSLGYVPTQLDICIYRCKHNGHSHYIALYVDDLLLVGPSTAEIDRVLDALELAYGIKCLGPAEYILGIQVKHGHNGSITLSQERYLRDILARFQFADAKPAGVPMQPGVVLNFENSSATPEDCTRYLQAIGSLMYAVVGTRPDLAFVVSYLARFSQQPGPEHWTAIKHVLRYIKGTLDLGLTYRKTNQPLHGYSDANWGACLTTSRSTMDYAFILSGAAIAWCSKREHRVAKSTTDAEYLSLSYASGDTIHLSELLSELGAPVPGPIVLYGDNQGSLALAQHPTNHQGSRHTRISEHYVRERVAEKEIEVRYIATGDMFANIFTKALGPKPFIFHRTNLGLRGAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NNB9</accession>
    <name>A0A2X0NNB9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C013g07103 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C013g07103</name>
        <name evidence="2" type="ORF">BQ5605_C013G07103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY14789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NNB9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY14789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="111" mass="12346" checksum="351F2E396B7C6197" modified="2018-09-12" version="1">MNASRMRRTPIIRGPQGVFRSPCSGQSTSSQAPLILRSTFDSARTKHRLTSCILNTNEGGKVEYPLPVGNELRLGRVIWKPSRAVPLLTGDEFDLLPVLEVNRAPGRQIRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NNL3</accession>
    <name>A0A2X0NNL3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C013g07193 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C013g07193</name>
        <name evidence="4" type="ORF">BQ5605_C013G07193</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY14980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NNL3"/>
    <dbReference type="STRING" id="796604.A0A2X0NNL3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015927059" evidence="2">
        <location>
            <begin position="22"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="164"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY14980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="328" mass="36623" checksum="AE882CC5D58F0EF7" modified="2018-09-12" version="1">MRFLTSQITLCLLVLVTSTLAFHVANLFPDLSVDAHRTVPSSNRRHHRCLAHSVRHNHHKKCRHSRKTGLKHFDQEKSAHTHGHLAHRNRRKKPAIKRLGKKRPVSHVDPNHKRPEHDQSNPPTILTGPTLQQPEPSGVHVSKTPAGKTAPERQIPDGKDQVSEIQALALEEINAFRALHNAPPLQTSPELVQNAVVWTSKCHYGHTRGAFTGEYGEIIARTSGSWGNNMSKAIELWTVDEENDFNPRKPQTTHFTQAVWKSSRLLGCASSDKCNDPADNSTTVTGDDIPPDEHNSVLYICRFLPAGNLNDKDTINANVQPAKSPHHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NPH0</accession>
    <name>A0A2X0NPH0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C012g06776 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C012g06776</name>
        <name evidence="6" type="ORF">BQ5605_C012G06776</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NPH0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="5">
        <location>
            <begin position="241"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="4">
        <location>
            <begin position="534"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="561"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="576"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY16152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="586" mass="65558" checksum="4CA40062F54D6E97" modified="2018-09-12" version="1">MSPDSRDTPLHMETPAQRVKLDMPLLKAGSKSRDVARWLAGCEDAVESAEWNYGKIATVHLICEAGSRMEGEGGDWYIDSRDKLKALKTWDDFAAEVKAQFVSEKTGLAAEHAFFNAQQSGMFNKFIALLTQERSQAGLASDGTQVIPDELFKRQLLHRCDELLYLRATASPSFALDKFSVNALVAYLQTMWDAITLERATTGMRRLNLRHERGEPTQAVGPRTPRLEGAAKEKAMFEGHCFVCDTVGHISSNCPSKPNTASPRRDPPGSTPGPRMVAAIRAYEDTGDSTAFVGISSDSEDENERLFAWHRLFGLPQSIVSDRDKLFTSKFWTALHKRLNIKLQLSSAFHPETDALVNKEQSNWAECLAVCEYAINSSLNVATRKTPFELVLGYTPSLASLAHVDGDDDLPSVEELLALRFQACKDARDQLAISKVWQAAQSNKKRQDEPSWAVGGLVLLDSTKLMDRFNGPYRIVKAQPEILSYTLQLNGDDAAVPFFHTGKLKTYRKNNTTLFPNREPARLGPVDVGGEPEYIIEDIVDKRIRAGKQQYLVSWLSWPSDSNSWEPAEALEDTEALDRWERRNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NPK7</accession>
    <name>A0A2X0NPK7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">BQ5605_C012g06806</name>
        <name evidence="20" type="ORF">BQ5605_C012G06806</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0NPK7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14879">
        <property type="entry name" value="MYSc_Myo17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036037">
        <property type="entry name" value="MYSc_Myo17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF45">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 15" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 15" id="KW-0505">Motor protein</keyword>
    <keyword evidence="10 15" id="KW-0518">Myosin</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="927"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="967"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1241"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1629"/>
            <end position="1653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1665"/>
            <end position="1683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1690"/>
            <end position="1713"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="18">
        <location>
            <begin position="14"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="17">
        <location>
            <begin position="990"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="domain" description="DEK-C" evidence="19">
        <location>
            <begin position="1904"/>
            <end position="1959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="15">
        <location>
            <begin position="666"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="116"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="SGY16215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1961" mass="216466" checksum="2775D36FD70BDC39" modified="2018-09-12" version="1">MPEAEVVIDPLELGDITNYSGTTPLGPNELVPILRARFLEGIPYTAISPRVLVAVNPHQPIHANSDATLLDWAAEYADCGSEGVRGRLGPHIWALSGRAYYHMRRTGQDQVVILSGETGSGKTEMARLMIKSFIDLSLPPVGKKGSKLATSIPSAFFILDSFGHASAIYNTNASRFGRYTELQFSEKGRVVGLKGLEYYLEKSRVTSPVVGERNFHAFYYLLSGARPEERAHLKLDEATSFKYLSHNRISTSGSSADATRFNQLKDAFKAVGFPRKAVASVLQILAAILHLGNIEFYFDKNRNADSAVVKNVRVLETAAEFLGVEASELEFALTNKATMVSGERCAIFLDADGAASNRDDLAQSLYSLLFSWISEFLNEKLCRDDFSTFISLVDLPGPVQSSSAAHREGAGLDAFTFNLAAERMYSFTMEQLFEGQKAEYVAEGLEKSLPGLRTAYRSNSETTRLLTTHPGGLVHIIDDQSRRRGKTEATMLSAMSKRWGKHDGFEVKESNAAAGRAGSFTVAHWDGPVTYSAENLLGDNSAGLSPNFVTLLAGSQPKIGVHRRTTPSSRDQLWTGGSTFSFVRQLFTSGALETVAHPQNENTIVEVTQKVTPRRAPSTRRPRGRVNPFADPSVEVDEVDAAAATTRTELKPSASRSIVRDVKDSLSLLLTTIASTKSWHVYCLRPNDAQLPNQVDARLLKHQVRALGLAELAQRLRGEWLVNLEIKEWWDRYSGTPALMQATQVLAPLMYRDKAAKAREILGFSDSDMAIGETKVFLNDGAFRYLEDFTRATDPEEQARNREKLDRDPSQVPVDTFSPYLMADAAPHASIGNFGQYDSDAALPLVHPGGLGYYAESDLDYDPKGYFDEGDGRASAWDDDRSMDPSSAFTNGNALFEGKNALDTEVRDGENHETVEEVRTSASRKRWIALTWMFTWWIPSFCLSRVGGMKRRDVRMAWREKLLINMIIWFICGCAIFVIVVLGNLICPREYVFSTGELSSRSYSNDPDNMLVAIRGEVFDLTSFAPKHQPGTSVIPIRSIQKYGGTDATSIFPVQVSALCNGVTGTVSPWVTLSSTNQTSNTVAQYHDFRASTTDSRPDWYTETKFHMDPFSTAMIYLRYNFRKGFKGYTPKMLKSQASSGNNIAVIDGLVYDLTTYVTSGGGGVSVPTGQVAPNNTDRAFMSGQVVELFTTNAGTDITTLINRLNLDATVLARQKICLRNLFLVGKVDNRQSVQCKFSEYILIALSCFMVAIIGFKFLAALQFGRARKPENYDKFVICQVPCYTEGEDSLRACIDSLTKLKYDDKRKLLCIICDGMIVGSGNDRSTPQIVLDILGADPLIDPEPLSFKSIGEGAKQHNMAKVYSGLYEASGHIVPYVVLVKVGKPTEQSRPGNRGKRDSQMMLLRFLNRVHFDAPMAPAELELYHQIKNVIGVNPSFYEYLLMVDADTVVEPYSLNYLVGAFVEDKKVIGLCGETSLSNAKASWTTMMQVYEYFISHHMAKAFESLFGTVTCLPGCFSVYRIRSVEHKPLIIADNVVTEYGENKVETLHVKNLLSLGEDRYLTTVMLKSFPAFKMKFCREAHAQTIAPDDWKVLMSQRRRWINSTVHNLSELMFIDKLCGFCCFSMRFIVFIDLLSTIIAPVTVAYIVYLIYSVAGEHKVIPTFALIMLAAIYGCQAVIYILHRKFEHIVWMIIYIIAIPFFSFLLPIVSFWQMDDFSWGSTREIVGEKGKRLIIHDEGVFDPASIPLKTWQDFENELWEQGSNESIGEMIAKREGAAYDGENQGQSQVYGHIGGGGGGEYYESNPFLGSGSQFGGSQAPPAFSSRGSLLDAMTGASPYVGATTTGMGARHMSGFDLDAMSEGPGGFAGSSRGVGLPSDEKIVADTQVSELEERLGVALGSFALTLTPVVSRLCAVLASADLSTLTKKGVRQELEKLYGCGLGARKALVNQTISEALGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NX87</accession>
    <name>A0A2X0NX87_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C014g07500 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C014g07500</name>
        <name evidence="9" type="ORF">BQ5605_C014G07500</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY18889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NX87"/>
    <dbReference type="STRING" id="796604.A0A2X0NX87"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF19">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="176"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="104"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="261"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="843"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="953"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="298"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="329"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="856"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="885"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="896"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="985"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1004"/>
            <end position="1021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY18889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1021" mass="109033" checksum="F11B81B38E920C9B" modified="2018-09-12" version="1">MAGGSTSSLVSSGVLHHKLTGGGTGGHHHHHHYSSAAVVPGGHSPRAMDWNALTVATSNAAANGWNSNNNSNSNEAAPASSSSVATPTTTFGTSNRVAAVVAAGGSASTSRGRSSSIQVVASAADEDDLDDEEDEEDDDDEDGANGGGGAGGGGDGDGDAANTPLEKKKSTRGSRACTVCRKLKMRCVGAENGPPCKRCKNGKHECIFEESQRGRRSNRKTDMMAKSLKKMEATLETVLKSISNPSMLTSSGLMQMSTSDLSAMNRGSGQGATPRDPGSVGAAGASSGDIPTGASPHNFHNSSISSGSPNFGPGGENKPRTTIEWSGIRGDRNGQTRDGSPRLHSLPDNTLNPLGLLAEASLQNTRKRTAVSVADVLEPSYGKEESANEPPAKREKLGMGNPQYFMPGPMNILPVRRIVIEQRGPPAILEEKIVTVEEVVELFAIFFTHCHRSAPFLDADIHTPAATGSRSPFLFTCICTVAARYYTKRKDDLYRKCHRVAMRVAFDVTTKGFKSTEICQGFLLLCNWNQPAERFEEERTYQFSGIAIRMATDLNLHRKTLTNLPADVSEETKALYQRELMNRERAWMYTYIADRSISTQMGKPFSIPKEDYLIRNARTWFLQPGAQPSDSGLSAMVEMHRIVGRMLDTLYSDTRSVSGLNPSLDYPLLMRSFLGQLDQWRSDWTEGVSTLPESAYTPDSIRHSMRDFYHSYSHVPSYRLFLLSFAIQHALDNPQSTIDLPSYTVMVFESASIMIGIARDVLEPTGILRYAIDSTFVYLSYAATFLLKLVSPSFTHIIDEESAIRLVRNVAETFERAAIDDTHTPALYASFLRALIDNKLNTGRTAPGSRAATRPSSPAHGAASMSGGAGVGMESYLKSRANSPGGEGLEGAAGGSEHHSSTNNEHFDSLAMDSMLSNGGFWDNMLMPGFGGPLQGLSGGTGTMLGTMGDHWSITPMHSRPGSPNPFGHSFPHFDFANPPSSSSGGQGGSASGGQGHQHQEHGAGQGGTGGSTGGGGTAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NYV0</accession>
    <name>A0A2X0NYV0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C003g02436 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C003g02436</name>
        <name evidence="3" type="ORF">BQ5605_C003G02436</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY40881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NYV0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="469"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="593"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY40881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="628" mass="68944" checksum="965F638D253DAD09" modified="2018-09-12" version="1">MSLSGLSASPPVSGLSRMFEFDFTAHDDAVITGQAFASLLEAIQKVLLARPSPGFIVRLNVLFALEGLTPLNPCEHYSCIASGLAYLVIIFIDYQRRGKKFWLWRFVHRPRGRFIVGNQHVLFTLLGTIGCLVLVGYTYDARITLGAARREEDNAFYWRTMLYSVVSPKCFVPIIIHGWVSSFANLQASLLSSQKVLNKHTLPPRWLNAIYTGGLTLLLVVSITLNVHASRAWAGVWRSGLIISNTLLLGEQEVAVGDLDPSLVELARTEVYNLNSHITFFDRAEKAVGGCYIVTMACLVAINVIGLSLVLTLRRQISFNTQRFAAEVKTNVRMSAAHTGDTAGAMEMGVTTTNNIQGQGIRTFQRSRSDVRQQASGEPSGIHSEDPSKGPESAERTDWADDTTRPATSQMNDVKPAGELPMYNRPQPVSHMSATKIKEASTKKTVASSKVLQEQAQNLLALKKIESDVIVLIGAITILAFILLAVGVWIVIGPSHVYRHWISIEFSLFLFPWAYVVTLALAHSALLYTAVKHLTPPSEASMTCRQALHPANWKRLARETVSGLTSTTGDNIDVPSPGNTVAQIAVRTTVEVHEDRNEDHNERTQEGGAPVVPGSGQSSATHRCLKHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P178</accession>
    <name>A0A2X0P178_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01139 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01139</name>
        <name evidence="2" type="ORF">BQ5605_C002G01139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY30289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P178"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY30289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="524" mass="54611" checksum="E2A39D2E21E05F2F" modified="2018-09-12" version="1">MTFTHHVNMHATPTASTSSSPPLVSLSASPRGTRRTSMSSTRLAGAAGSDERRHIRQQLSTSPSGGTSSPLLASNGRTTAPSFLYLPPGISLARNGCGDHSSHQFIGSGSHTDRPGSNAPLTSNGARSIDYFGAPSLHPNAAPTPPLRTTIGFEPLLEAKPAASSSSSTSISRKLSSSSCSSSASSSCCASTSSTSNGPISSLASSVAASDDISTSPPSSSSSTTTKRPSSASRPAVPGEDPQLAAARRALWEDVNPPMMKKTTMSTHSNSGSDDSGSMTPSAQACPVFDEDEKEVDNQAQEGSDTEDEPNPDTVPPHEPSHATLTPLASCLRSETPSRTPSTNSLSNGSPSGSFVRISREPPRAFTTYSAIDYERRGQGPVEKLSIKEWMELQGVREAVGVWSGRITANDWSEEPSSINGMSTNGPGTESSEGSEPIIAIGKGHPSVATGVRRVASLPNSPMPLTLKDLPPPKRAISGPLLNDEDDHESTTTPQALKPGYYKGVRTVAHNVEPVEAPSSLWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P1X1</accession>
    <name>A0A2X0P1X1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C002g01558 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C002g01558</name>
        <name evidence="7" type="ORF">BQ5605_C002G01558</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY33832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P1X1"/>
    <dbReference type="STRING" id="796604.A0A2X0P1X1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042285">
        <property type="term" value="F:xylosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051292">
        <property type="entry name" value="Xyl/GlcA_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12270:SF25">
        <property type="entry name" value="GLYCOSYLTRANSFERASE-LIKE PROTEIN LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12270">
        <property type="entry name" value="GLYCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13896">
        <property type="entry name" value="Glyco_transf_49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY33832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="602" mass="67335" checksum="C63706AFE0B85E4A" modified="2018-09-12" version="1">MLRRNAGKPKSTSSRLGRLAKFCLTVYLLAALGYTAYHFVVDPAVRAVLGSDAKVEQERLRLAEDQTAAVRAAGAAGAPAGGADGTASATLISQIAAHMPGDIMTAVDADGKTKTKNRHAALETAGVRASDIRQEDSHDKVWAAAEMAAKAGKKIKATYVKPKELIDGRELVRTRVGGLENVEWDADLMVWHPPSHPHAYSGPSPDASHWNLDTGPRSQLALSEDQFLSLSFSSSLQPSKVIPYYYRATDPDRPDFNKEDITITTLITSNRLEVFKRLVERYQGGLQRVTREPAPWIEALTYLYPRSLGPISATVHLPDSSAHAETLQVLDEAYNGSSLMRKYVDIHLVYDSFDRQFNMWRNVAKFFARTEYVMMLDVDFWLCTDFRSRILGSEEIMARLRGGLAAFVVPAFEFAKQSDGVDPSTFPTTKEELVKLVEAEKIGMFHKSWAPGHGSTNYTKYYAAKPGEVYRVTGYTHSYEPYAIFKKEGTPWCDERFIGYGGNKAACLYELYLSGVSFYVLPDDMLIHQSHAYAEKARQHERRYNRKLYIDFREETCFRYLNMFIDQIGSPRAKNLAQECKKLKGFPSTAARYIAAASGNSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P2K5</accession>
    <name>A0A2X0P2K5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01818 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01818</name>
        <name evidence="2" type="ORF">BQ5605_C002G01818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY35930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P2K5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="548"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY35930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="577" mass="64681" checksum="D810D932904DE417" modified="2018-09-12" version="1">MARGLAQHGGWCGLQHVHLSPGLTTFCSLPLSVVYLDSKPSDHTICCLSCLLPVTHASVQSTSSPEMGSVLTSSATVQTQQHHISASSIAEDGRSTTLASRPTTSNSSNSMSHRIEEVQDEIRALHDAVRALPSTSRLSSSQKEIHVLYNLQRRLEKMQYCLRHGVRDDDLDSYTPPATRSNDRNDWNDFKTSRFFRCLLEKNGLEGKCSVCLPDSSQNRLLSITRRYSDRQIHHSDPYKVPKDFSALQAIGSRYWEQVKNSPELWEQWKEARASEARDRKETAQPLKRWRIDSATISKLRRRYENAMNELVEQYAEGYGFDALVIVSSNKLENKNDRFIVSTLGGAAFMRRQGWDSDQQKDILVNFTDCVNGTRFNQEQNEQYKMRANHGDVDKASQRVLCAWYSIIIDDHYSEQPFHGSAPTFCSLVLNICGRADQALRRRHQRNRSTQPYVLSKLTSYNQATLAKDPIALIVEFGNGLQERDFRSPTNGKKPTVADLRRIIPLMRQGGLTFSLKEEIGQGSFDRTRAEGTVTTGQLETEPEDQVSGSDSASASDLGSDSNSNSDSDADLGAATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P352</accession>
    <name>A0A2X0P352_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g01971 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C003g01971</name>
        <name evidence="1" type="ORF">BQ5605_C003G01971</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY38172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P352"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY38172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="89" mass="10324" checksum="BAA62E82433ADFD5" modified="2018-09-12" version="1">MKYVTYHLKLTITDCHLQQYQTLWISPPLVFIVQHDTSQPRWPTKSLALCALQCDWPACYNSPARLPDRTVSIPCSLMPFFLFSTASQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P3I2</accession>
    <name>A0A2X0P3I2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C003g02170 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C003g02170</name>
        <name evidence="4" type="ORF">BQ5605_C003G02170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P3I2"/>
    <dbReference type="STRING" id="796604.A0A2X0P3I2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF236">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY39212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="247" mass="27036" checksum="E1D110B9D63A5875" modified="2018-09-12" version="1">MPDLSGKVIIVTESGYDLQWGTNVLGPYYFTKLLMSIRRGAPWRFATTSRPCVLQLPALKASKSASGTPSRVINTSSLAHGYAPTSAPNKVWEVDTFVGGGKRDALIKKWREYGARSTLYGQSKAGNIAHANYLRREHAGDIVACSLHPGMINSELQRHLPGFVASIVRWMSYPLTMGALTQLNTGTILTPEEINGKYYQPWGRVGHPTPQSIDPARADEAHQSCEAEFAKGKFRSPAGPIPLMPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P3U0</accession>
    <name>A0A2X0P3U0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g02211 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">BQ5605_C003g02284 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g02211</name>
        <name evidence="3" type="synonym">BQ5605_C003g02284</name>
        <name evidence="2" type="ORF">BQ5605_C003G02211</name>
        <name evidence="3" type="ORF">BQ5605_C003G02284</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P3U0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY39402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY39841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="80" mass="9024" checksum="B376A730DA952F15" modified="2018-09-12" version="1">MSQPPKIDLPFQPSNIEGPFPLNVYADPTKVVRFPTHPDPTRIPAPTSTATPSPIQQQRHAIPRVQRPRPVRQRPQDDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P6I8</accession>
    <name>A0A2X0P6I8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferroxidase</fullName>
            <ecNumber evidence="3">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C005g03493</name>
        <name evidence="13" type="ORF">BQ5605_C005G03493</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the frataxin family.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="3"/>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY76479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P6I8"/>
    <dbReference type="STRING" id="796604.A0A2X0P6I8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034986">
        <property type="term" value="F:iron chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.10">
        <property type="entry name" value="Frataxin/CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017789">
        <property type="entry name" value="Frataxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002908">
        <property type="entry name" value="Frataxin/CyaY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036524">
        <property type="entry name" value="Frataxin/CyaY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020895">
        <property type="entry name" value="Frataxin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03421">
        <property type="entry name" value="FeS_CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03422">
        <property type="entry name" value="mito_frataxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821">
        <property type="entry name" value="FRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821:SF2">
        <property type="entry name" value="FRATAXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01491">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00904">
        <property type="entry name" value="FRATAXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01219">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55387">
        <property type="entry name" value="Frataxin/Nqo15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01344">
        <property type="entry name" value="FRATAXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50810">
        <property type="entry name" value="FRATAXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0409">Iron storage</keyword>
    <keyword evidence="6" id="KW-0410">Iron transport</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGY76479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="198" mass="21929" checksum="49C0E4E7A1B5B150" modified="2018-09-12" version="1">MNRLCPSTVATWRAFVPRSSTSIPVARCQRSALLLTSVDRRTKPRSRADVGCQTCRCFGSMAKASSAAASATSRAYATGPLTVQAYQKAADEAMDRLTDYLEELVEAAPPELKYDVEYSSGVLTLHVGDKGTYVINKQPPNQQIWLSSPSSGPKRYDYDPRHGVWFYHRDGTLLEDLLTEELRNAMDDPSIHVTLSNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P6U9</accession>
    <name>A0A2X0P6U9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00776 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00776</name>
        <name evidence="2" type="ORF">BQ5605_C001G00776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY49391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P6U9"/>
    <dbReference type="STRING" id="796604.A0A2X0P6U9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="773"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="846"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="422"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="790"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY49391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="937" mass="102139" checksum="D9CEF57BC529F06A" modified="2018-09-12" version="1">MESEPRPNLNKERDSDSSTHNEVGSNTNAQNGTRTVDGTTSTTAAKKKKKRKTPAQKKAAAAAREQELQQDKAASAPHVLKISRNKHMKYISSYHGPWLQLPHEVLDTLLTVNCDESALPTVRGLVEPPSSTPTMDRARFHAIAAGPHERRRSPSPSPIPQMNRGGGEKEAGNSHLPSPIDPAVFRGVSQIRKLVDDASDLAVRAAVGMSAAALGSFGSGGGAPPLSACPEGGGRNAGMSAVRQHRLRVLAVSKLAEAYRIDEIAASVAIMQGATGLDDLAQRVLKQEPDNLDALYVHFHHEKIPSRTLASSTDTTQLDHLIACDPHRLEYYRTRGVVHGFKQDYVSAVRNFTQALTEAKAIRKEKEHRAEVQVGGGNLKKKKGGKNGKMGGKKGKTSLAPMGDRNEVDMAPILGSNGNAVPTTPTSDPSSTVGKEPGDDLERQMYFHRAMAHFHHACRLMEDAALDVEGVQKPKGGLSNEGGELTLRNVGIVLADEIGGLYGNASPEKQARYRVGMGEASLRERVTTLLRKSVRDHERFLAYFKVWEAPPGNALEEEDRQRPTLGAKQTDRPLTFRGRRLIHHRALAQRTRDADPRRLERQRRHQDVPMPAPTLLTTYHPLIIESHFTVLLIHLLLGDFKTLVQAHARTVRLMDHLEGYPIFLPARSLTMSEYAEVLERLSATWRIVRESSGIAAPDLDMTEVELARGEDELACLHQVCGFFSTEFVEALVRQAERERLAFVAKKEGAVGERRKGLGLENGLGMGKAKEIMDGEEGEEAKGKRNVTGSWKEERDKADAERRKIDPSYATYNTARAEVALAWLQAVILPEKEAEQLAKTHVQWHNPTTSHHDDAQTPLGATNSIGKGKEKAVSALSSSSSSSSSASAFTQQQEAFFGSGSGEFSNSSFFAMSGSGSTSGITMAEAAEAGGSKTEKVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P8P5</accession>
    <name>A0A2X0P8P5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">BQ5605_C006g04232</name>
        <name evidence="20" type="ORF">BQ5605_C006G04232</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY57170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13650">
        <property type="entry name" value="Asp_protease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0229">DNA integration</keyword>
    <keyword evidence="16" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="18">
        <location>
            <begin position="550"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="19">
        <location>
            <begin position="1086"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="SGY57170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2043" mass="231741" checksum="711D8E87BE9EA555" modified="2018-09-12" version="1">MSEPHEDAPPRWKLHAPSYLCRTDRTLSGLRLFWSRNDRYFKKEKIETDVDKIDMIGQLLLDPELKVWYSSDAASHVNKKYGVFQRDLTLRALPSDYMWQHYRRLDNLRQTGDYREFSTAARDLQLELGVSLVSDTQLVRMLLLHMDEELSQRLRLSEVIKGTGLSPDKLDASIVKADSTTSSAVFDYQTFDAEARRLWQVISATRASVKATAQASAKTVRSTPTLRTTASPSTLPPLSSKTRAPPMTDRERAFLRSNQGCFKCRKINAGHFKDTCTTWATSACKVPAGWRQDKIDDKGEELHCLCDDEYDNGTDDERCEPISLSVKLTTEDGPALRALVDTGASASFIADREVEKLRLTRRKLQVPTSVSVAIQSHRVSHPVTEFVCVPLRTLNGRWSTQHVVLKIAPLTSLKVVLGRPFLKRHDILVDWKRRRVLAPDPTLPGKRIDLMHRGEKGEWSESAVQASIRACLAHLEEQQAEESQLRALEVAFRKEFSDRFPADIPPVSQYESKVRHRIALKPGMKTPRQPTYGTPMRWRAAWRRLLDEHLAAGRLRPSSSEYSSSAFIIPKKGMDTDPSIMPRWVNDYRILNAATVPDRTPLPLPDEILAVAARARFWSKIDMTNSFFQTKMAEEDIPKTAVATPWGLFEWVVMPMGLSNAPATHQRRVNEALSSLIGKSCFAYLDDITIFSDTMEDHQIHVKEVLEALRRADLYCSPKKTELFRTSCDFLGHVISRNGIAADQSKVERIVGWPRPRTVTELRGFLGLVQYLRKFINGLAQHTKPLADLTSKNANVRLMWGAEQERHFNAIKAIVTSLPCLKPIDHTDSADPLWVMTDASNVGIGAVLLQGQDWRKAHPVAYWSRQYISAEVNYPTHEQEFLAVVDALRQWRVNLMGVHFHVLSDHESLKYLKTQENLSKRQARWVERLADYDFDITYIPGGENTVADTMSRYSFPQGEPDSVQAVSEMDIDTQLRGRLVEGYDSDPFCQQVKRNLDSSPGFSCVDGVLYFEGRMVVPAVPQLREDILHDAHNALGHFSPCKTFHQMSRTFFWPRLQTSCNAYVSTCDVCQRTKATTTGALGVLHALAVPDGLMQEVALDFVGPLPKSQGFDMLLTITDRLSGYTRLIPSLAADTAKDIAERFHEGWHRFFGPPTRIVSDRDKLFTSHFWRAYHNLMGTRLAMSTSFHPETDGRSERTNKTAIQALRAVVNKQQNNWVRHLVNIEFAINASVNASTKIADLIAERKAVLAEVRDALAAAKVRQAEQVNRHRRPEPDIAVGDFVMVDTRDRRLRFKTGHRKSAKLFDRFEGPYKVIAANVATSNYTLQLSEGDRSHPTFHVSKLRPYRANDPNLFPNREPARPKPVIVDGHEEWVVREILEETTRGGKRYRVWWEGYLQHEATMEPRENLVGTEALRCWELKKRMEGRVLVNYYCLILSFHFNPPSKDYPTTPLLSSTTSVGRLPGPLPRAYFTPERLAIIEDTQRLYPCQFNFTRTINDLYLGKLLAEHPNAILVNSFLSAFRSEGFESPHDGSNARGDDPASVRFPKNKHHREFIQTTVDEEVKKQWVSPGSAFPLPGVTYNSIFVVESTNHRIRVVADHTSSGLNDGIQRTDCPTIYDTIIDFIRLLRWHRFALGLLTDTSVLWKLDVSSAFKILIMSKRWQARQGIAIKRKLSDGTLRTWYHIEWRGVFGCRAMPFLWTRFMSLLMWAAHNVYGIEHPLAYMDDAFGIDLAGSMVAYNHNGTTHTIPAQQAAMAALWTGLGMPFKLSPDKAPHGRRITITGIDCDLDSFSVSLPHKAIEDLLREIDVFLLKPSRHPTLRKWRQMTGWLSWSLNVAPQARPYLTPLYEKLAGKKRSDVGVPINTSTAQVSLAGACLKDADVVIYTDACLQNATGTGAGLGFWFEWKGTVHHYYCRPQQTYKRIQFAETLTVVLALGIVTHPSSPFKPLSRVLVRTDSAPAVYAVDSGAAKDGDFMPLRTLTLRSYVMAQHRKFDLKVIHVHGKDNTLADDLLRQHEVQLHRRFSPLTHFDPFIPGLEGVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P978</accession>
    <name>A0A2X0P978_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C009g05665 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C009g05665</name>
        <name evidence="8" type="ORF">BQ5605_C009G05665</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY83941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P978"/>
    <dbReference type="STRING" id="796604.A0A2X0P978"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098852">
        <property type="term" value="C:lytic vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04159">
        <property type="entry name" value="Arl10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001120">
        <property type="entry name" value="ADP-ribosylation factor family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044154">
        <property type="entry name" value="Arl8a/8b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732:SF7">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015908866" evidence="7">
        <location>
            <begin position="21"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY83941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="177" mass="19522" checksum="C9C88501F1254A1C" modified="2018-09-12" version="1">MFQAFLNWLRSLFFSKLCDIALIGLQNSGKTSLVNVLAAGEFSSSMIPTVGFNLRRVQKGNVIIQPDIGGQPRFRSMWERYCRGVNAIVFIVDSADQDSFPSAKAELHALLEKPQLGGIPLLVLGNKNDLEGYAKVEEVISALALSTITNREVSCYSISAKSKKNIDITLSWLIKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PDS1</accession>
    <name>A0A2X0PDS1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Geranylgeranyl transferase type-2 subunit beta</fullName>
            <ecNumber evidence="3 11">2.5.1.60</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C008g05079</name>
        <name evidence="13" type="ORF">BQ5605_C008G05079</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="3 11"/>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PDS1"/>
    <dbReference type="STRING" id="796604.A0A2X0PDS1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02894">
        <property type="entry name" value="GGTase-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000012">
        <property type="entry name" value="Geranylgeranyl transferase type-2 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026873">
        <property type="entry name" value="Ptb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF11">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="12">
        <location>
            <begin position="13"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGY79223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="339" mass="37773" checksum="15C0EAFF16B52A9B" modified="2018-09-12" version="1">MTSSTLNAPPEELLVDLHVKYIQSLDEKRDHLYYHTTQHLRMNGIYWGLTALSLMRRKDALPRQEMLDWVMSCYDPVIGELGRDCGGELGGFAPHPDHEPHLHPTLSAIQILATHDALHLLDTDKLVQYVLSLQSPSGAFAGDQWGEQASRFTYCAVSCLSLLDRLDDLDTDRTVSWIEACTNFDGGFGMCPGAESHAAYVWTCLGTLAILGRLDLVDKDTLCWWLCERQLPCGGLNGRPEKLEDVCYSWWALASLAIMGREHWIDAQKLKSFILSAQDPDEGGIADRPEDLADVWHTVFGIAGLSLLSYPGLEPVDPIYCMPAEATKRLVGMRRGDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PEJ3</accession>
    <name>A0A2X0PEJ3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C008g05389 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C008g05389</name>
        <name evidence="2" type="ORF">BQ5605_C008G05389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY80450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PEJ3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY80450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="767" mass="84821" checksum="30130874A9D72250" modified="2018-09-12" version="1">MMNKQRARSPPSPPLNKPLASKRQTRSATRASLKLEHCDVKSPSPLVYLPLSVTAYPLNAFPFNEHTPVKHKSLVCNCHLACEANVKDPSFTRAVGLVSGFIGPELAALSSSLKLTLPELDKDVDRFFIEDEIVPRVVICSASDLVRSALGFDATQFKRQAQEALARPGRSEVQVLFDKDCRRSPDQRVADWVVPLADFASCGSHRQNNLKLAHAERQARLTFGDATRGHDHVERHHFLTCCDELGSGNGGTGTHSMLVPLAFGTAPPTEFSFLTTARMYAPGLAILDNKAHLVVLDHEGCRIAIIPDCWGEGFGELALVLSVLLGLEVYSAGLSPLFRYALHPKTGIAPVAFRTLYLRPAELEADAPLFGRTVEFVAEEPIELVDCRVAGDSSIFGRCTIIFELTRPSLVQGFSSTSDLTPSFVLKVQHINQKSKGGEAEVLDKIAQCCTSHAPSASSLLIERHVSLSEKANSLGLHRSQMDDSALPVLMDPEYPERQLRESSRRTLDLLVVRNPTPLPIRVDAGRGSQHKLSQACEVFDQLLTLLPALWNLGIHHRDLLLGNILHYEGHLVLVDWDTGIVAQPGSRVPIAADVAGSFRITDATASYEALGYPRGLVNGCYEVPTHDLRHDFESSVYWFLHVLDWYIYESVSAELWETLQLRALANEPTVSPALIRMDLWEGAANFPKLRQAFLEDLATVDTEVHDLVDVMTCVRPGSHPTIFTSDSCVKQKMVEVQAELRRMLERAQQPDYGGILGRYHRLLKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PFS6</accession>
    <name>A0A2X0PFS6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C009g05649 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C009g05649</name>
        <name evidence="1" type="ORF">BQ5605_C009G05649</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY83675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PFS6"/>
    <dbReference type="STRING" id="796604.A0A2X0PFS6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY83675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="98" mass="10657" checksum="2B0C9D11984B92D0" modified="2018-09-12" version="1">MRTFVASKLVPFTGRLVVERLRCSGSYENGFFSFLGGDSDYVRILVNDRAMDLSSVCGKGETLTSGTVCRLPAFLKAMEKATATATKEFAQCGFTTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PG44</accession>
    <name>A0A2X0PG44_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C037g11579 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C037g11579</name>
        <name evidence="8" type="ORF">BQ5605_C037G11579</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000062">
        <property type="protein sequence ID" value="SGY93246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PG44"/>
    <dbReference type="STRING" id="796604.A0A2X0PG44"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018866">
        <property type="entry name" value="Znf-4CXXC_R1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10497">
        <property type="entry name" value="zf-4CXXC_R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zinc-finger" evidence="7">
        <location>
            <begin position="289"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="374"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="572"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="752"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="189"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="374"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="421"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY93246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="981" mass="107709" checksum="34BB15EDAF287FC2" modified="2018-09-12" version="1">MSSPPIITSSSRSTLDSSSQHGPTASASASAAAAQPTAPAVISRDELGSEDGASSDDPLDVLPPSSSSPIALHKPSACASRHSNSQDPSPSLALNSGRGRSRTRSRSRRSSMSSLSSLDSEPDEMETRRIDHEGALEGAHPGSAKTNGARRNIFANGHGSSSKKRASSPSHFGFVSPKRRTTEAITIDDSQDEIDELEDDDDDNNTGRQADDEEIDELDQIQDTTSISHGKSKTKGKLVAVASSSKFKAKATTTAVKGQQNASDDGGKRVYCHQDPNHFVQDHQAHDSLKETMWRCSAIKTSAKGSHRACGLSYCEKCLKSRYEPEASGMNAPGARKNWSCPLCRGICEFASARRRSELVKQNLAPVGYLKSKTEKAVAEETEKAGKPKKEKSVKGKAKPRVEKKNEAGQQPGSKKLGASTNGKPTKGTAKAAKTKEPKASQSRKGVRGPFSMNVDTESSLSSLSSDEDKPSATTAGAAVVVPVKRRNPPPRAPKFVRPPKTYPLTRSTVIPSNGLLIARLHLRSFILRFSGFAPVLTTESAKIRSVLGALADDRDGWVWSREGDVVQRFMLQALCELLDQEEENIATEEGSAKLLRRLAREAVGSQIEKDRAWDTLREIVEQENVWDDGGWGEEVVKWEAEREEADRVQFGGQRETRGRRGETGPDERLALMLALVELAYAAECVRKDFTDGVEAEKTAMVTHNRSKFQHRHDCEDRRKAIFAEKPEKPKLHIDDMLTDKDQAKPNHDRELAEWAAKCADIDDRLKEEEKKWQKELNEIHRDVYLVTAENRLRFAPTGTDVHDNQYWLMCPSTASKFPTEADPATDDYPLSWSILVHGSPFSEIDPVAAAANGNKGKTIAAPPPSPPPTPGTVASINASRVDHKDSWFVVTDPEEMIQLVSHLEWQHKWAEYEVRLARHEKSDAGTRSLTPLGGEDDESTVKSISDLVAELRIFADYVAAEKEDAVNGNRKARKNKKRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PHX7</accession>
    <name>A0A2X0PHX7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BQ5605_C049g12445 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C049g12445</name>
        <name evidence="11" type="ORF">BQ5605_C049G12445</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000111">
        <property type="protein sequence ID" value="SGZ30725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PHX7"/>
    <dbReference type="STRING" id="796604.A0A2X0PHX7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051644">
        <property type="entry name" value="TRAMP_AT-DNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543:SF1">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="10">
        <location>
            <begin position="311"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="10">
        <location>
            <begin position="350"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="206"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="252"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="456"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="78"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="481"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="530"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="544"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="601"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGZ30725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="687" mass="74703" checksum="865763CC3883A604" modified="2018-09-12" version="1">MGRLQPPKKPTTSSQRTLSLPSPPPQSKTAISSSLLSPSSRPLLIGPATRIEPTATADETQAATTSPFISFRLPSPKPTSFSTTSTATTQASTSTAPPTLSIRSSATATATATATATANLAAETSHSTTTQDQDQDQDQDQDQDPTPPHKRGRGRSRANKKKNPSGATTNRSKEHSPDVEEGEVQGDFDGLFVVDLQPSVVPEELLETPTVSEAHEHKNETAYERRRRQQAEDLEREEQAMRDFAHDVLATDDEHDHDDDHDDEEEESSEQEEEWHDEASLAKAIQGRIVDDSQAKVTGRYYKEADPSKSCVLCGEQGHSSRDCTHSQCFICAQVDADHEARNCPVSLVCSACGSRGHMARDCTAAHPVRGNYGARCTHCSSTLHLPTNCPSLWRIYDTRGAKPTKRRVILACANCGSNKDHFIDECPIPRGHPMKYVDNSAFNREALGDWAIGLPNRVGQRGGPTGSEAAAKRRGQPMAGDKRRTHERFDPADDDDWFASRRTDSGRRNGYHDSRDRNHGRSSLTDRLSYGDDRSSRSDSIDTRPSASSSSSKKHQQSQSGSESTPRGRRGSSQGGGGHIRFKNSTYDRFGGTPISGPESGRKDLRSTYDDDDRLQGGRDSGRDRGRDSGRDSGRDNSRRSTPNGNGRSGKRKSDPTGGGGSSGTPSLASRLGGLPTKPRYEGGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PI14</accession>
    <name>A0A2X0PI14_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C033g11202 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C033g11202</name>
        <name evidence="2" type="ORF">BQ5605_C033G11202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000066">
        <property type="protein sequence ID" value="SGZ02344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PI14"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016083625" evidence="1">
        <location>
            <begin position="21"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ02344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="141" mass="16298" checksum="DAEA77E002B9D809" modified="2018-09-12" version="1">MVYFHHRLLVLISGLSLLSTSFIAKPVKRLSCLPWTPSYYNDCHKTCHENAVNTDIKCSGLHPISNPYERWKYFQCLCDDYAGFDIEFSQCVDFGIDNTAVCKNPNDIYQQELDWCNVYPSGKTKPKLRFCRKNTTVEGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PJB3</accession>
    <name>A0A2X0PJB3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C029g10709 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C029g10709</name>
        <name evidence="4" type="ORF">BQ5605_C029G10709</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ15887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PJB3"/>
    <dbReference type="STRING" id="796604.A0A2X0PJB3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF444">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13650">
        <property type="entry name" value="Asp_protease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="572"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="187"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ15887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="711" mass="80139" checksum="082B9613F4D697D5" modified="2018-09-12" version="1">MIKTHQHSRRHSRRCQKIKTDVDKINIIGQLLLDPELKVWYSSDAASHVNKKYGVFQRDLTLRALPSDYMWQHYRHLNNLQQTGDYREFSTAACNLQLELGVSLVSDTQLVRMLLLHMDEELSQRLRLSEVIKGTGLSPDKLDTSIVKANSTTSSAVFDYQTFDAEARRLWQVISATRASVKATAQASARTVRSTPTLRTTASPSTLPPLSSKTRAPPMTDRERAFLRSNQGCFKCRKINAGHFKDTCTTWATSACKVPAGWRQGPVSPEQVASLSDAVDEIDNKGEELHCLCDDEYNNGTDDKRCEPISLSVKLTTEDGPALRALVDTGASASFIADREVEKLRLTRRKLQVPTSVSVAIQSHRVLHPVTEFVCVPLRTLNGRWSTQHVVLKIAPLTSLKVVLGRPFLKRHDILVDCKRHRVLAPDPTLPGKRIDLMHRGEKGEWSESAVQASIWACLAHLEQQQAEESQLRALEVAFCKEFSDQFPADIPPVSQYKSKVHHRIALKPGMKTPRQPTYGTPMRWRAAWQHLLDEHLAAGRLCPSLSEYSSPAFIIPKKGMDTDPSIMPHWVNDYRILNAATVPDRTPLPLPDEILAVAARARFWSKIDMTNSFFQTKMAKEDIPKTAVATPWGLFEWVIMPMGLLNAPATHQHRVNEALSSLIGKSCFAYLDDITIFLDTMEDHQTHVKEVLEALRRADLYCLPKKTKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PJB4</accession>
    <name>A0A2X0PJB4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C011g06471 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">BQ5605_C072g12891 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C072g12891</name>
        <name evidence="2" type="synonym">BQ5605_C011g06471</name>
        <name evidence="2" type="ORF">BQ5605_C011G06471</name>
        <name evidence="3" type="ORF">BQ5605_C072G12891</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000123">
        <property type="protein sequence ID" value="SGZ34329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PJB4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY12333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ34329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="281" mass="31644" checksum="AE7D5CE9B2FE1E6C" modified="2018-09-12" version="1">MPTPTAPSHSPTYKPNDPPQLHSTSMEALREYFMRLDFYNRRIARTPITSDYNKIEGAGMGLQVFALKTWFAQGLSKHLAKPYTQFKSELIRRAVPADFVWTQLAKLHRLRQAPGHDIDAFQEFSDQMRSLQMEIGFQVVSDQEVAKLVLLGTDPELCRILRTHMVSSLAGWSDLPLEKLALDTPVVPTSPEAAEVFSDAHTDQPLEFDYQVFERIGREEWSRPTYSRPAAASAAPHVTTAATGHSPITGGPRPVARLTVDERTYLDQNHGCYCRNRTAMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PLK4</accession>
    <name>A0A2X0PLK4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">BQ5605_C025g09972 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C025g09972</name>
        <name evidence="13" type="ORF">BQ5605_C025G09972</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal/bacterial/fungal opsin family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000087">
        <property type="protein sequence ID" value="SGZ26844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PLK4"/>
    <dbReference type="STRING" id="796604.A0A2X0PLK4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15239">
        <property type="entry name" value="7tm_YRO2_fungal-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000160">
        <property type="entry name" value="Related to Opsin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001425">
        <property type="entry name" value="Arc/bac/fun_rhodopsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018229">
        <property type="entry name" value="Rhodopsin_retinal_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043476">
        <property type="entry name" value="Yro2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286:SF1">
        <property type="entry name" value="30 KDA HEAT SHOCK PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01036">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00251">
        <property type="entry name" value="BACTRLOPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01021">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00950">
        <property type="entry name" value="BACTERIAL_OPSIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="295"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGZ26844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="338" mass="36757" checksum="18470D5207B31FDE" modified="2018-09-12" version="1">MGNNALALNPLSSNIDITTHASDFLWAIFSIMAASGLGLLALGSTRPLGQRAFHHLAAAICFTASIAYFCMASDLGSTPIAVEFIRSGSLGANWVALGVDRPTRSIWYARYIDWVITTPLLLLELLLATGLPLTEIFTTIFLDEVMIVTGLLGALVSSKYKWGLFTFGCVAEFYIWWMLLLPARKSANNLGGGFPKMYALSASILSTLWILYPVAWGLADGGNVITPTSEMVFYGVLDVLAKPLKRSSFTPPQPGFCFYHCIAMSTCDYNRLGFVSGKYSQAATAEERYYNTQHLNHDEHTNEHRSSTATRVEESSLNAAAHHGSTAHPGSKPTQAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PN99</accession>
    <name>A0A2X0PN99_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C119g13275 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C119g13275</name>
        <name evidence="3" type="ORF">BQ5605_C119G13275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000109">
        <property type="protein sequence ID" value="SGZ30353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1008"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1590"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ30353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1799" mass="197721" checksum="D0FAC9629825C38C" modified="2018-09-12" version="1">MVLLYDPSSPPSQAPALARAAQRAVRNDAMPASNVIRVIMDGTGSPRGPVQIALRKHFGLAETPFMFARPEGAELDPEVEKLFSKCVKLNPIVTKATKRFPIARHMYELVFESDQACLEAAAAGPFPYHGKEMVTELPSVSPLNHIVQVRFTLPSSSSAIPASVLRKSLDAALTSSFGHAGCTQGYTLLQLQRGLAVDPNGDPMAMTEDGFHCAYLRLHADLFQGSTETQKAALNAALPQEIEILGAKYGLRHEFETHYCAVCDRAGHRWGACRKPVSTPATAAPVPGASTSTSTSTSTTGFRVAGKNGKHGGPAALNSRASGTNMIQLGPRANPAGSATGNKDDANDGDGDDDDDDDGESVASTEPEGGDTGKETLTRATTGPTKETQTTTAAPVSTPTSPSPSTSAPASPLSGGTSESSATSTTSIASTSPRRLRSSSAPGNRRVTRAGSAMIHGASGVTTQGATVPGSLTVLTFNVRSIKNAVNQVKIIRYLKTLRPAPAAILLQEHHLSYNALRERFESAWPGACIRFAPHVLTLIPDGSPLAGRLLSSTPVVFAEAPQFDGRILRSVFRLEELDIEIINMYAPVKGEERRDFYGLLHFTAPGPKTLRILAGDLNDCPDVSVDRVAITDRAWTPVSHWQTLLSKIAFNPLDTIRQLHPITPAFTRPHYLGRGDKREICSWSRIDYILVQRSWANRLLSASTLFDAPCSDHRPVVATFALPTSNAADAEPPPALPTTSEFISRLNPTVFNDQDFVDSIPGVVDEVYRRLEGTAPLGDVYDAALRAVAAAGHARYRSTRADMRRLRAENQSVMEALEARGEHMNEAERDAYALAKSQLDQLAVKEAQWLRIRAHVPSVDSREGQSASIRTRLNRRNRQTSIVSLEDVDGTETVDMQEALGIASRHAQSLFTPDPARGDPTNARRSLLDPIRAAKCYDDDRSDPTFGRRLPLQARVALDEPFNLSEVKAALKKTDSGRSPGPSGIPYELFKALPTYFAPKLLDLFNSIWEGGKMTASLAEGLVRLLPKNKPGANLKSLGAYRPITLRETTYKVLSKVLVARLNGVLGELLPPAQHGFMPSRRSADAGSHLTLLLEKLRSLGTDVFPEGALLSLDQQSAYDRVDHAWIFDVFEAFGFGERFISLLRALYDPETLGVRYLVNGFPTELVRLLCGLGQGDPLSCPVWNITFQPFLDALVRRGIALDLQKVWPGGPRAQLTHLAFADDAVVVVESPAALSKLETLSQTWYEATNGKTNTDKTLVLPLGPNWLRDETAQALPTVQEGESFKWCGYAFFRHGDSKLFWTHVLDRIKAKARAARDRTLSPSGRVFYANAHITSTVLHVLSFDIPPQWFIQAAETALTDFVWGGPRRNTVAREFVFQTREDGGLGLISIGDIVHSVALRFWDAVAGSDEAIWAPLARESWRSLVATTRDFSPWGFFSSTARVEKLVTLPTIKSELLALPELLSLPPRLPSLYAEGAKHAYDDADAVAKFAQIADLYWRDEGKGWALVGHRRGFWQHSKEPALRHEHVWARVGQKLKAKALLPKTAVRPARIPLKEDPHPRCFNFFGLTRPFTIRKLRRLVNKVRFPGKDGQDRALPGGQPQEPRVRRFPEGTSQSGRQRFWSWLHDRFASAAEQDTHWRLMYDVTPTRKKQHVQGHASSPSCLFCGNDAAVIETVSHYFFGCAYSASYWSGVLRILFDKLGIEDTDVDPSTFTQEQLTMGLPLLRGRGRTTSKWMWVRLACAIGFQRLHLLRWHVHQRFEKDRVVAPPSIPSALRAFNRDYLSRAGFVPGARDWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PQ61</accession>
    <name>A0A2X0PQ61_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C040g11852 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C040g11852</name>
        <name evidence="6" type="ORF">BQ5605_C040G11852</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alkylbase DNA glycosidase AlkA family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000118">
        <property type="protein sequence ID" value="SGZ32311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PQ61"/>
    <dbReference type="STRING" id="796604.A0A2X0PQ61"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032131">
        <property type="term" value="F:alkylated DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043916">
        <property type="term" value="F:DNA-7-methylguanine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000004">
        <property type="entry name" value="DNA-3-methyladenine glycosylase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051912">
        <property type="entry name" value="Alkylbase_DNA_Glycosylase/TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003:SF5">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="5">
        <location>
            <begin position="130"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGZ32311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="445" mass="49299" checksum="31E0F8DD6C5C99B1" modified="2018-09-12" version="1">MLTRARNQPLVAPLTPPKAIRSGSKRVSLSTNVITPLATPRTPPPSARKRRKTEDPPTAAPNNTMGSVPAAREEVSTVLLHPPLAFSFEEATAHLHSIDQRWGPVIESLRCKPFQPSEAEDLFDPFRSLVSSIIGQQVSWLAARSILHKFQRVFYPTLPEKLERPQAGLEIEEELRQRTSPFPTPQQVIDLPNRTETLRAAGLSGRKVEYVVELSERFVDGRLNAKELWSMDDEEEVERTLVACRGIGVWTAHMFQIFSMKRPNVIPVGDLGIQKALCKWYSSDPFTPPLLHPKKLSGPDPSTPKPELEAESTAALLSLPVTPTSPSISAGRVPADASTPFETPKKQPVKLEEAYPSPGATPLRVWAAPITAPFVFPPTTSGLTPSILKTRLAGKKSIVRDMLMPRLGPRRGAYLTPQEVRELCQPWEPYCSVAMWYLWAVLSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LSP2</accession>
    <name>A0A2X0LSP2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C015g07720 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C015g07720</name>
        <name evidence="3" type="ORF">BQ5605_C015G07720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LSP2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY17245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="348" mass="39691" checksum="768C50C9C290BC8C" modified="2018-09-12" version="1">MQEVALDFVGPLPKSQGFDMLLTITDRLSGYTRLIPSLAADTAKDIAERFHEGWHRFFGPPTRIVSDRDKLFTSHFWRAYHNLMGTRLAMSTSFHPETDGRSERTNKTAIQALRAVVNKQQNNWVQHLVNIEFAINASVNASTNKSPFEVVLGRSPSLLPTSLNRPDLPDVPAAKDLIAERKAVLAEVRDALAAAKVRQAEQVNRHRRPEPDIAVGDFVMSAKLFNRFEGPYKVIAANVATSNYTLQLSKGDRSHPTFHISKLRPYRANDPNLFPNREPARPKPVIVDGHEEWVVREILEETTRGGKRYHVWWEGYLQHEATMEPRENLVGTEALWCWELRKRMEGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LT96</accession>
    <name>A0A2X0LT96_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C011g06422 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C011g06422</name>
        <name evidence="1" type="ORF">BQ5605_C011G06422</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LT96"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY12194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="43" mass="4960" checksum="FE16D3BD5049A934" modified="2018-09-12" version="1">MVWWKGVSRASRVEQVLCGLDAIRQVACTIGDRKFSCWSRGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LU28</accession>
    <name>A0A2X0LU28_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C011g06640 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C011g06640</name>
        <name evidence="1" type="ORF">BQ5605_C011G06640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LU28"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY12883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="224" mass="25426" checksum="7119432105393DD9" modified="2018-09-12" version="1">MPSDSRLLDAVRIQLSRSQSQGASLIVDASRRASSRIDVGHLPHSRLDIEVTTDFRQWNMFSVRGKVSMKRRSSQMRAINMRLITSFSSTFASLTRVVSKSVQDPPCSFSATAISKGECSVWTIIVFNEAHSHRSLLHTGDSKSRLTRHRFNLFPLGPNGSCIVFLVSVMRSWRRRGYHYHSVASLQAYTTSDQTQVPGCGREVQARHDLWSLQRPRTQPSYMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LUU4</accession>
    <name>A0A2X0LUU4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C017g08400 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C017g08400</name>
        <name evidence="25" type="ORF">BQ5605_C017G08400</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY19947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="510"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="257"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="787"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="267"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGY19947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1360" mass="150959" checksum="E526DE376C3FE662" modified="2018-09-12" version="1">MSPSETIAQESGEIKIAKLGKDNYELWSIRVEAYLESKGYASVLEHGHVRPSDVSLAEWRTMHGLDASVTDTQVVVNLQKKDRSARALIIQCIDDANLKMVKSKTLSAKDIWDKLRQHHEGNAKPFKIRTLLMELSNAKYDEDENMGEFLKSMIDKADQLDDLGQKFGDEAMIAYILQALPPSYEMLKQAIRLGENRSVDHVINRLTDEYTERKLSGKFDKLLKNAGALAVQSTQASRDPNCVCRGCKGKGHFAMDPECPKYDAKKNHGRARNRNKKKKQDSKESADSNELAEFVLTVKSLDESHSLQDNVANRVSQVNQGEIWILDTGASQHYVGDASLLSNRQSGNLKVQTASGQVVHCDTYGMVRFKLKSGASLSLANVYHLPGAPVNLISTRALFKSGAKCGWEDGKDVMTITYQGVILAKTLSGTGYALDFTRIVEDQAHVATRATVGAPLMEWHRRYGHVPVSSIMELVKSGAVEGLVLTDEKVHDCEPCISSKSRASKFSELATQVTDVLQRVFMDIGFVAEDQVDFQGRKAYLAIVDQYSTAKWTFPLKTKSAEEVTRVWIAFRQGVEKMTGRKIKRVRTDNGTEFTNKLIGADFQSQGILHETSAPYTPQQNGTVERFNGSLMAIVRAVLAASKLSWKYWSYALAYATFVANRILHAKLEGKTAYEVFYGKKPKVSHFRPFGSTVYAQVPKSKRSKLESTSVKGIFIGYDSEYNYRVLVDPDSDHKVIVTRDISVLEHKSEQVGVPEVTTLPVGPDEEKGPVDNDEIVVDELQDQVDGEQMPPAHQNRRRWEYGDPAVKGRNPGRYEEIDANNEIPHRTRSQHRDAEQQVMYGSAMSVSLPPVPSNYEEAMASPEADKWIAAIKAELDAMARHQVLIDSDLPSGARALGSKWVFTRKENAQGEVTRYKARLVAQGFAQRPGIDYNETFAPVARPSTILSLVGTAAAQGLFLEQFDFDSAFLNGTMTEMVYMNQYEKFIYIALYVDDGMVASNDQEFLDSENEAFNKVYKLKRLGPVKLFLGLEFERTSDYIFVHQSKYIRDLVAMYGGGSVSKHPVKVPMEPRSDVEHSTDPFDDVALYQSAVGALQYAAHRARPDIVTSVRAAASKVSAPTQADWIAVKRIIRYLQGTVDWGLKFNHGGSTVFELYSDALWGDDMSTGKSIGAFVSILAGAAISWQSKQQSMVATSTTEAEILAASAAAKEAMWLRRLAADLELEQPKATLIWEDNQAVIAIALNPAHHGRTKHYNVHHFYIRERVTAGNIRIKYCKTGAMTADILTKPLARNLFELHREGMGMVSLGALTRTYGLSSGAGARVLCGGPAEAAGCLHEIASFWPSCFSLFSTTHSISHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LW95</accession>
    <name>A0A2X0LW95_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C012g06834 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C012g06834</name>
        <name evidence="4" type="ORF">BQ5605_C012G06834</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LW95"/>
    <dbReference type="STRING" id="796604.A0A2X0LW95"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027193">
        <property type="entry name" value="Noc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455:SF0">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="3">
        <location>
            <begin position="441"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="325"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY16295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="692" mass="77220" checksum="6771E11EC69840D5" modified="2018-09-12" version="1">MAPPQSSSLPSKGRSTSSINQPNASSSSTQEPDEVLHRITSLSSSLPPIAPTHADLNPLIDLISLFQHLPLQPPPNTTSTSSWYQLNRQAVHTSLHALKATFEALINHGRLHGVLKRKIAPGQGASSSSSKEQAALEMASVQKVKEWLQERWADYLKQTATVVQGHWDMGVRVRQLITIPSVDSIPADPPTHARVHQISALNALMSLLRTESTFLTSLHHSRQAQFPSSTLVHILRAILLPQDDEGLIVPEIKDEWQKWWNVCDDIRYHFLKGSATLLSSYASSNQDVPTHLVSNMITLFESLTSMPTVPKELNEWWCSTPTALKSKGDKSNKKRKTETGKSKDDGSTGIFDSSSSSESDENAPKMSARDSKKLLPPLLSLSAHRRVFQDCVLALLSLPLDEAQSKRVLSILHRQVLPHMTDPKRLMDWLVDCTTQGGTIAILALNGLFTLMQKHNLEYPNFYSTLYSLLTRSLLHTRYRPRFFRLLIIFLSSTHISASLVASFIKRLSRLALSAPPSAIVTIVPLVYNLLKLHPGCMTLIHNPSPTDETIHTDPFDPEEKDPNLTRALESSLWEIQSLMQHYLASVAGLAKVFKEVMNKERYGMEDFLDHSFATMFETEATRLIRNAPALAPVPQRQPIGDSFFPSTPAAERPTKVVKKVVKRSLLEDEGDEEEVEVEQGPVDTVARLWVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LWD4</accession>
    <name>A0A2X0LWD4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C012g07043 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C012g07043</name>
        <name evidence="5" type="ORF">BQ5605_C012G07043</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ADIP family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LWD4"/>
    <dbReference type="STRING" id="796604.A0A2X0LWD4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021622">
        <property type="entry name" value="Afadin/alpha-actinin-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11559">
        <property type="entry name" value="ADIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="114"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="217"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="495"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="340"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="495"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="510"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="533"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY16958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="542" mass="58801" checksum="7C643249C76BDBE0" modified="2018-09-12" version="1">MDEPTTMDAASLSHLSSQLQSLGFLSRPLDVASLFSAAAPTPTTAKGGTHDDPASILAHQATMQQQYRAREQVLRCLWSLLTARNDAAEGLEAVSARERVLAYEVERTKAMLKREREAREASERDKQNEKAKAQSATAAFTTEQTRHRHAREELVRARSALQLVRTQAQLDQKRRDATVSTMMARLQRLTADPAQTKFVIANAKLANVNSVVASAVAGGPSGRMASSARSAPPSSRAEDRSSEEVVYWQSALEDCESERSRLALENEKLRELVGEVAEWAELMLDTDTVNNKEAREIGEGFAADISLSVPSPHLALTVAELATPLHNKLYQIRCGVAALVAGVEDRLEAARTELANQLEREHAELQEAKKVQVDVEHELAAAREAIAQSDKLMQDFAARQLSSAAGPVVELKDAVEEETAPVVVSPPRRTAVSQAEPAPRPSIATADRFEAQRAQDVAAFLSDLGLDSPAPTGAPLESLAAKVAKLQRAPLASTQAITATTSTSASASDRLQKVLERTRVEMSQNGQRKENTKTASRPSRQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LWH6</accession>
    <name>A0A2X0LWH6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C015g07748 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C015g07748</name>
        <name evidence="2" type="ORF">BQ5605_C015G07748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LWH6"/>
    <dbReference type="STRING" id="796604.A0A2X0LWH6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="662"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY17324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="714" mass="77756" checksum="C10D485BEA7C3CE3" modified="2018-09-12" version="1">MPVRFCTLFVSLERQCLLPLHSRNFSTLLLPAMTTASSSTNDHAALSSTESPAATIGGAAGVHVALLLPPMQLSGALDTTAGTTYDGALFDISAETIKWAKDRKDPPMSCLSQHPQVKIRQDARYSYVLLIKEAVDPMTASIIVGGAQSPSEMFDRHFESVAMRTCDSNWFIMRKYDSTVRSLWWSGFKVSKIKVFGPFDQSIMAQVSAALNVAMKWAELAAEHQSSCARVMERPVDDLIEARGRIQAMEEATLGGEDWKPILPLLKPVVVAPAVVVVTSVVPLSAVPRAAACTNYNSRRVCITNLSPLSCRAATSASRPRRYLSGIASSASVLWFRGCYLSGIASRASVFWFRGRIPHRSRFVTSAYPRADVLDSNLRFSLPGRIPTVRASSRPCTCRCLVPTGSVVLSKVVTFQASRRVPPFSNLGVKSPTARAFSRPRTCRCPVPTDRLGASRRVPSFSGSGVESPTVRASLRPHPLSAAPADPPSITELPIHGVGRAPLEPVAAGSKGDVLFVSSMPALGSSPAPKTSARMRIMAREVDLFRDARYKIVTPLDAEGFDFGIKDPPSERHIAKNAPLTKKQQLVMDGEMERLLDLGYIAGPYDKDELQAAVGPFCTNPISYVPKSVAPGMPPKWKQIENLSYPTAKLIDRTTDPDKANHPSQRSGSSSRLKLVSINDDLKSADSPCRWTTLPMLYRKFRKLPSTAEVCGWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LWY8</accession>
    <name>A0A2X0LWY8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C018g08770 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C018g08770</name>
        <name evidence="4" type="ORF">BQ5605_C018G08770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY26749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LWY8"/>
    <dbReference type="STRING" id="796604.A0A2X0LWY8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015959530" evidence="2">
        <location>
            <begin position="23"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="3">
        <location>
            <begin position="2"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY26749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="361" mass="40170" checksum="ECFDA242B12CA0F5" modified="2018-09-12" version="1">MFAPTAKFVSICTLIALAAARGYHIIQADIDKAYLHGELEEELYMRVPEGIRLPDNVCLKLHRSIYGLKQAGRVWNKTIHKTLVKLDNYYIAVYVNDLLFIGPDLSEIDCVLNELDQLYGLIHQVDGIALSQQQYLLDVLARFGMADANKSVLPMQPGLQLKPCDTPDPLLQTQYRSAIGLLMYAVVATWPDLAYLVLYLARFMNKVGSNHWAAVLKILRYIKGTLKLGSVYKAKRDLLVGYVGYSDSDWGSCINTSQSTMGHAFKLADRPILGVLGSRAEWRQCQFLRNLLAELGITICGLIKLKGNNQGAIALTKNPVQEGDIVVKYLPTAEMLADMFTNALPRPALEQHRAAIGMGIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZP8</accession>
    <name>A0A2X0LZP8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C017g08564 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C017g08564</name>
        <name evidence="5" type="ORF">BQ5605_C017G08564</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY20279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF463">
        <property type="entry name" value="REVERSE TRANSCRIPTASE TY1_COPIA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="385"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="616"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="619"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="640"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="653"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="683"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY20279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1311" mass="144681" checksum="40E506D160CC155E" modified="2018-09-12" version="1">MADHITQMRADYNAIEDLSDEAALRPLAFKEFVNKVKIAMTDFQNLGAPLPHWLFAGMLVRSLPAQYDSIVGNLASDIDIHMVWNTFYPKLLMNVEMADSRNKQKESLSARIVDDTSLVARISTTAQKDYSKSYCSRFKALGHERGWRLCPSRNKDASAPASSDSISNVAAIGVDESALMTYTFPYSRTMPRFPWIIDSGAKVHCVGDKSVLSDVISEPLKISVADQSQIESPGHGSVTFLTSYGARIIIKRVYYIPGAQCGFISIDRLLESMTYAVGPQSNLIFSIRGKSILRSLPGRGFVMDAAPVQPIMSSSLPSMVGANRLTGTCTLMEAHLKLGHQSPAAIVLAVKSGAITGITLKDEKVTPCFSCIQAKSKRSPFSNKSTEAPHALYRVFIDLGFVEHPNRNGDTIYLAIVDQYSTAKWTIVLKDKRAETIIEAWSKFQAESERQTGQKIKRVRSDDGREFNNSLFRALLEKQGTIVEFTAPYTPEQNGQVERLNGSLMGLVRSMLLDSGLPMRFWSDALAVATFVLNRRPHPRIQGKTAIEVLLGKKPSLAHLQPFGSTAFVHLAPRSIQGVFIGYSGEYNYRVWVQLSKQVYVSRHITFLETPSVVTSSQDHADASDPVHHSQPPHPPPDVLPSTPTSPVVDPALPDPQPPPVVPIEFGQQGGGDLAVVPRKDDDNDDNDGLDDGPDNYHDAEEPLDGEAEVVLAPREGYAVVRTVPNPGQFENVDPSNILPAGSRRRPQPPENILPIISAIMVDVLDTPPMFHNKLSYDAYCAAVFAEEDIEIPKTFEEAMKSPYRNHWSAAMVSELLQFDHHGVFQEVKWHEGIRVLGTIWVYSIKRNANGKIIRFKARLVAQGFAQRPGIDYHDTYAPVAHSSTILFLIALAAAQGLYLEQTEDVYDRYPKGWNRPQPPGKCLKLVGSMYGTKQAPRYMRATADACLYIKHSSTSFAIITLYVDDGLIASNNQSFLDSELGSLHKAFQLKRLGPVSYFLGFEIHRTKDYILVHQSNYVRTMLEKFDFASSSNCRAVTPMDNRPSLRTDATPFADVSLYQSAVGSLQYASTRFRPDIAIAVRAVAQKNSCPTVDDWAAVKRIFRYLNSTIDLGILYRNSSTTQLMVYSNASFADDPESRRSVGAYASMLAGGVISRQSKQQSTSTTEAEILSASSATREAIWLHHLAGDAGIPQAQPTIIQEDNAACIQIAKDPVDHMRTKHFDIAHLFVQERVASGEVELEYCPTHVNAADIMTKPLGFQRFDQLRALLGMVSLVSLTGGSSCRGVPLSPCCNSTGESDHSCTVEPSSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M0Z0</accession>
    <name>A0A2X0M0Z0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C018g08789 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C018g08789</name>
        <name evidence="2" type="ORF">BQ5605_C018G08789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY26786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M0Z0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY26786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="508" mass="56261" checksum="77AD7758252A1483" modified="2018-09-12" version="1">MPTPTAPSHSPTYKPNDPPQLHSTLMEALRKYFMRLDFYNRRIARTPITSDYDKIEGAGMGLQVFALKTWFTQGLSKHLAKPYAQFKSELTHRAVPADFVWTQLAKLHRLRQAPGHNIDAFQEFSNQMRSLQMEISFQVVSDQEVAKLVLLGTNPELCRILRTHMVLLLAGWSDLSLEKLALDAPVVPTSPEAAEVFSDAHTDQPLEFDYQVFERIGREEWSVIAQRRQAIATQLLPAIPRSRVPPPPVARLTVNECAYLDQNHGCYRCHTLNADHISRNCPRYLSPMGASATPSTPTSTAPAPRPGPRMVVAIRTFQETGDSTVFAGLSSDSEDDNDPSYTPHPFPPLPISLAGAHGILLASALVDSGSPQTFLSEELVQRLGLERRALEQHSKYTLAMQNQVPTVFTCTHFVRVPLELANGLWAAGPTYTKVAPLGKDLAIILGGNFIYRHKMELGLFPQPHLTCKANPIHAIDLLALSSCEAMMPAQAVVSLKSKDQGRPDQEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M147</accession>
    <name>A0A2X0M147_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C003g02278 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C003g02278</name>
        <name evidence="8" type="ORF">BQ5605_C003G02278</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M147"/>
    <dbReference type="STRING" id="796604.A0A2X0M147"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF683">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="495"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="139"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY39800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="537" mass="59589" checksum="1199B965E14AAA13" modified="2018-09-12" version="1">MWWEGFGMSTAVLTCQVDLSACSFSFFHKFNPGPIEVRSRFPTGKRHKASCQNRDQLHFLKPRQLIHGGSERTELLRRKTIKRNCWIICKWILQLRWMTSRSKACARKTLSMFLRCQVRTQTPKRMLSSVSHRNRAFILPRVFSKVGLVPSVLMLILVSTMTTWSAYVVGTFKLRHPEVHSIADAGYILGGHIGQEVLGVVYTFYMLSVCAGGLLGFSTALNAVSNHSACTVWFVLVSAVITYIFAIIRTIGKLSFLGCIGVTSSLIAVTTTAIVIALQNKQPSASRHTDYGLATFHFLGRPSLVDATHALGSIVFAYGGVPAFFTVVAEMREPKKFHRVVLCCQGFTTGTYLLVGLVIYIFCGDVVLSPALKSAGPVFKKVCYSLASPAIIIGSIIYLHLAAKYIFVRVLRGGPHLTTNSVKHWITWISSVTACLVVAFFVAQAVSVSEHLVDFVGAVFGSLMSINIMGMMWLYDNFHRRHCEQTWRFRGLVAWNIFMIVGGLFICIAGTYVSVALMIVAHRGKALPIFRCSDNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M283</accession>
    <name>A0A2X0M283_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C001g00093 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C001g00093</name>
        <name evidence="1" type="ORF">BQ5605_C001G00093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY43960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M283"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY43960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="589" mass="65223" checksum="75EABED4F4ECAF79" modified="2018-09-12" version="1">MYQHTVVSAAPACGVGVSIRSHVQALWSPGTQGGPSQPRQVLGARVAPYHGLPWACSSARCWAPHGSTLFFVPHRSTESAPAHVMTTMQPILALRHVYEPAVQLCRTDSVVSAMANSTLGSPHHHLRKGECAGAKILRRELAPRARIALKPLKPHVSIRDDLGPQTAVCTHCKARHWECERSKSTRHFSACCSQGKVRLPPPPQPNLEYRQLLQGSDSGHIPRKRPVAQQRAVFHFDQTRIGTLGLPVFRVFGRLYHRLGALIPAVNQRPAFAQTWLIDPAEATNTRLQGPDSAETRIQRSTLTKLESMLRTGNCFVREFASAKGRAGWDTAKEWVLRLCLPPGRDRRTHNLPTTLFSRCTVIDVPMVGPSTKSLARSIRPRCLSVTHYFFLQGKMASTPTFLFAGSTKPGRQSPETESRSTMVSNCARYLPVLVWMTKTNRRTKTATMRMKTARKGTKRMVMANVCVFGSFSEAPFFSRSQFFAHYLPNAASTSQSRIATNVPSWTIPGCDGVRCQTWKTSAAHHDDVRPRLTGNQGCTGADKACNRPDLIARVFEAKSGNKRHAGCFGDECKMNGFCFFAAFRIVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M2D1</accession>
    <name>A0A2X0M2D1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C002g01120 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C002g01120</name>
        <name evidence="9" type="ORF">BQ5605_C002G01120</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY30126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M2D1"/>
    <dbReference type="STRING" id="796604.A0A2X0M2D1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1710">
        <property type="entry name" value="Subtilisin-like superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010435">
        <property type="entry name" value="C5a/SBT2-like_Fn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF66">
        <property type="entry name" value="SERIN ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06280">
        <property type="entry name" value="fn3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016114603" evidence="6">
        <location>
            <begin position="23"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="7">
        <location>
            <begin position="231"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="C5a peptidase/Subtilisin-like protease SBT2-like Fn3-like" evidence="8">
        <location>
            <begin position="635"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY30126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="958" mass="103479" checksum="EA127D5B0B7A395E" modified="2018-09-12" version="1">MRVGNSLAVLAAVAAIVPAAFAQKTQVFGRYIIVYPESNKEGKALHARDHLSNLRARSGVESLEVVQEYHMSGVLVGHSVNALGVTKEQLEKMPGVKAVYPVFDYSFAAVQQQKGEPPSQSFQQHHNHRKVKESGAAPPHLELRDQQFLGQKNMPNTTGGFSPHRMTSIDILHKRGFFGQGVKSCFIEGHTQYTHPLLGKRGCFGSKNCAIQFGADLVGTDPNHPQPGPDPHADCDVRSTHILGQMVAPENRFDFVGAIPQAEIGWYSIFPCGGGGATGDIIIGAFLKAADDGCKVISNSLISSVGWNDNDLGPITLNKLAEEKGVFAVSAWGVSRDEGLFYPAGPATGTEGVGAAYVDLNQYPFAYTLTFENGEATLPYISVYPIPYDDSFEVYFLSTSSTDTAATGCDDLPHDTPDLSNRAVVVQRASCGFETQMANVRKFGARVLLVVNYPASVGWPAPYFDGIAPSVPFPVGMIHSDGAKLLEYYRKNSNGLKLNFKDRTLIHPVNADTGGKISFYSSYGPDNSLTTGPTFGVPANQIAGIRPNGSVGTIDATSSPITNAIATLVLGARKNDNLKPDELRSLLATTAKPISIHPRADGEPLETTTLAGSGLVNALRAVEAQTLVTPFSFKINDTAHVQKEQQLTLKNVGRASITYTFDSTAAQTKMTYDGGAKQDIVPSSLPTVLQEAEAKVSFDKTSITIEAGQTATVKVTITPPQLTAREKDYFPVYSGFINIHASNKQEFHVSYFGLAADIVDMPIIDVSTSFASAFRSGLPQGLTYPYLLDNSPNSVKVPTQLTTFDRSIGVGVFIRFAQATRHVTVDVIAGNSTFKGTLPSHEGRNHRRSLNAADENHLVARRLARQSRADPNQLYTDVQVLGRIYEKKNQARDDKGSPDALVVFKGSMQKDLSMDGQASDLPDGMPYRVLVRALKTTADPSLEASWESWVSPPVQFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M3A9</accession>
    <name>A0A2X0M3A9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C002g01601 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C002g01601</name>
        <name evidence="3" type="ORF">BQ5605_C002G01601</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY34238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M3A9"/>
    <dbReference type="STRING" id="796604.A0A2X0M3A9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051654">
        <property type="entry name" value="Meroterpenoid_MTases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897:SF1">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY34238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="290" mass="32100" checksum="079F21C096B47145" modified="2018-09-12" version="1">MDPVYYNDPLDVPVNLEDEELRRNSIDPSTSLTDHLHRLQAEAYNVHPYPCVRKWNFARYKIKRNHLGYDRALAHGHQDRSVILIDAGCCMGTDVRSLVAEGFPADQLLGTDLDDRELNLPVRFLALGYKLFMDEPSSPSTPAFLAGDLFSTSFLAAPVADPSTSTSALPAPALKSLTSLTPLLVRVQHIHCGSLFHLFGEAKQAQLAHKLFALLSRTAGSTIFGSQLGSSIASLCDRWKKLWADLSEESGVKLRVMTALEDRAGSKAMPIIDDIHKYKINNLVWCVTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M433</accession>
    <name>A0A2X0M433_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol-4-phosphate 5-kinase</fullName>
            <ecNumber evidence="2">2.7.1.68</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1-phosphatidylinositol 4-phosphate kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Diphosphoinositide kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">PIP5K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C001g00700</name>
        <name evidence="14" type="ORF">BQ5605_C001G00700</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14425"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.68"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.1.68" evidence="2"/>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY48829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M433"/>
    <dbReference type="STRING" id="796604.A0A2X0M433"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17303">
        <property type="entry name" value="PIPKc_PIP5K_yeast_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.800.10:FF:000009">
        <property type="entry name" value="Phosphatidylinositol 4-phosphate 5-kinase its3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="13">
        <location>
            <begin position="605"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="122"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="191"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="284"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="467"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="547"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1010"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="229"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="301"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="467"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="498"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1010"/>
            <end position="1020"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00078403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00080374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGY48829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1033" mass="114352" checksum="9F182F0E257B980F" modified="2018-09-12" version="1">MLVQRDHASELPRSSSLNLDVHHPVHPAPPFESPPSLAVATPLDTSLARQTRTGSASHGIELGPLNVGNSNSSNSKKRNDDDDDETDDEEAQVNPLFAISQRVQAGSLESVHVIDDRSVVSGHPTPSLLHPSTWSAPSIPRHHKNNHNTNNDSNQNSGKDSPAAMVHLNGAPTSSEYGKGAIARTTSALSTSSSSAGASFTNGKSHVSKLNQREKERERAMSGSSQHSGHSERFVMHGEGNDDPAPDEHTVCHLREYDVHSSKREAWKMKASDWKIGMRERMHSGDSSSYHQADHHHCDDPSISSQLSRSLHSQPSHLDSHERPVIISLNEFTNEPVSMVLPESDTPTRSELPVSMIASTSSPPGLNGTPSNTIAGPSGALVLQGAPILSPISQVTSSPRSAIPVLNAPGYLVTNSRIPPVPTVANGASTSDPSMNGHGSPAQRLVPIDSLTRPLLPGDIALTTVTSAFSGDPSSVSSSSRNRRSHSSAETTCPGYVSPPTATTSLLPPLQVSHRTMNASMVTSPESTAAPYDEVESSIAAQAEVIRKKRQEKRAEKETGGDNYGTSSNEDRSGRPGAPMIKRRSTRLGSGDGPGTGVLVGNLIGQDHANYVLMYNMLTGIRIGVSRCQAKLKRPLTDADYTARHKFSFDIVGNELTPSVKYDFKFKDYAPWVFRELREYFYLDPSDYLVSLTAKYILSELGSPGKSGSFFYFSRDYRFIIKTIRHAEHKFLRSILKQYHEYIKENPHTLLSRFYGLHRVKLPRGRKIHFVIMNNLFPPHRDIHETYDLKGSAIGRKTPDEKVQENSHAILKDLNWIERGRQLDLGPEKKALFEEQLRRDTELMQKLRIMDYSLLTGIHNVRRGNQDNLRDNMLTVFQPDTFKTPRRKLTDAKRDFDAAAVRKAVQQSDPKALSETNKLPDQDTSERRMFLFYQDEGGIRATGDCNEDLGVIYYLGIIDILTPYTFVKKVEHYWKSFKHNGHMISAVPPEEYGDRFMAFIYSLIRGNDTSKRPKMYEHDPPPPSTAATKPKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M5C6</accession>
    <name>A0A2X0M5C6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C003g02514 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C003g02514</name>
        <name evidence="4" type="ORF">BQ5605_C003G02514</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY41458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M5C6"/>
    <dbReference type="STRING" id="796604.A0A2X0M5C6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="525"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="555"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="312"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="472"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="582"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="483"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="496"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="582"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY41458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="620" mass="67161" checksum="42F2EA504E3BD0BB" modified="2018-09-12" version="1">MSLLSSFDRVYPSSSCLPLSELQLPSEAPDLDHQCLPFSPLSAAAAAFFGSHDYHSLQHSTQVDPNLGSNASSPPFSDSCSGYSSSSASDASSFPDSPPRFSFDADAAAGVFSASAPSAAAVNVTASTARARAQNQAAHAHVHAQAHPGLSSAAGNAASLTTPIATTTDGSSYYSTYDSDYCPSTRSTSPASSFVHASPKLDQQAFAALNGFDLPQARHAQNAQAESDSTFASRNQSAPMLYYTDAQQQQLQQGAPMYQQASALPFAYANSSSPAYLQQTPAVQQQQQYYYNQAIQRQQQQQQQQAQRHMYAQQQQVQMSHMQHQQQQQQPHQVPQQTPVAVAPAFETASGTYYFIPSTAINPSVAHAAEPWSAMPEQMQQPRQMISQAPPQQQQHDVIQQARQLPAHQISPVMSSPVASLSRADSPLAAPLARVPVRDYTISGLTKAASTISTSRSQSNSPVMHSEVDELLPTQSDAPPSPKAKTAKATTTTRRAAPKTRTAKRGGRRGAFYGESTGKSETKRFVCLYEDCGRAFSRNFNMQSHLKSHLNIRDFNCPCCPKKFSRRHDRARHCAAVHNMHDLADNPDHQSESTSSHRRSALASSGGDEFEDDKDSTYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M658</accession>
    <name>A0A2X0M658_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C003g02502</name>
        <name evidence="10" type="ORF">BQ5605_C003G02502</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY41366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M658"/>
    <dbReference type="STRING" id="796604.A0A2X0M658"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057254">
        <property type="entry name" value="UCH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF17">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00140">
        <property type="entry name" value="UCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="9">
        <location>
            <begin position="8"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="7">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY41366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="221" mass="24863" checksum="6F349076D177BF01" modified="2018-09-12" version="1">MASKERQRWLPLEFTAESFNTWSHSASTRPLQDCYGLDAEVLGWVKQPFKVDLRKGPTRGRRSLEEDGVEHVADIIYFKQTIANACGTFGLLHALANAGVPLEPGYLTKLFEQCKDKTPLERAQLLTARPTSSSGCTSKLLRAVKRLQTPDLDTQVDLHFCTFVEHKGNLIELDGRRNSPINRGRTTRNLLQDTAVRVKEIIELSNSLEFSLITLNPTPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M6G4</accession>
    <name>A0A2X0M6G4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g04259 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g04259</name>
        <name evidence="2" type="ORF">BQ5605_C006G04259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY57340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M6G4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY57340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="320" mass="36606" checksum="CF4C0866BFB08786" modified="2018-09-12" version="1">MDQLHQVVNLLENRAPNHLQLEYDTMQAKRQAIMSSNLLWSAEEKADYGQWPLILGDRRKADEWTLKDTIPILKLPLYMATEEAKLTKFFLTDPPPILHWRNQPEQEHEWIGCKYERCLAVLVEARLSDHTFRFHDSLRRSKESVDDPNISSPEQNFANCLKNIVPFLTARAEGPIPRVTGGSDRPTIPYAEWEGVIVKPRVLKKGDLMPRTEFTRQPDGNACGVFVCRTMETLVAAVAFQSELDWSWSPVKPLQDNFYANQREYMLDVVKHARLRCDTELEANSDPPPLDLREGSGAPPPVPVRRSSMEAPHAAVLQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M6V9</accession>
    <name>A0A2X0M6V9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C001g00489 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C001g00489</name>
        <name evidence="1" type="ORF">BQ5605_C001G00489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY47042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M6V9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY47042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="532" mass="59871" checksum="ED77C3CCF8204A05" modified="2018-09-12" version="1">MAFPAPSPQPSLPGQLPDKEPQPAVFPILQLPPEILLCVIKSVDVGTRAISPTFPCGPSRELLCLSETSVYLHTLCRPLIWRSVNWEPQSIRPPSRRPRQVIEDVEAAREYAARVTRWKVRGMRSLLELMQEAKESTRGPIKIKALSYTGYDDGEFGDDSIAAEPDVQALCDILNDHGRQIQVIFLKAVVVGQELGRSLILDILYLPKLSALRLHSVTIHNQSRALDFFDQMMGPLPPLRTLQIMHGSPKLVSSKHRGLGGLTGSLPDPSLFCANQLQLVGCMTDLHSLLLWPGSRQFGSLTPFIVRLLPQLRLLSLDSVGEPGVFDALAEAFEDMSEYQTLPLEELFLEGRQSLPRRQILLESLSHLPKLQRLALFHLREAKPRLIADIAHYTPQLRALTLIHGDASSSVYWPSALQDYVDELKKLKRIEFFAWDRRSPPAPRIARTSDEGEEEERPNQLRLEYSTLHSLGKGLPTLKEAVCVTQDTSEASSGYFAEYSFTPQGARRVDVKKKLVRDFLVDFERWCIIVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M7W4</accession>
    <name>A0A2X0M7W4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">BQ5605_C001g00587 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C001g00587</name>
        <name evidence="14" type="ORF">BQ5605_C001G00587</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY47890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M7W4"/>
    <dbReference type="STRING" id="796604.A0A2X0M7W4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048476">
        <property type="term" value="C:Holliday junction resolvase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033310">
        <property type="entry name" value="Mms4/EME1/EME2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21077:SF5">
        <property type="entry name" value="CROSSOVER JUNCTION ENDONUCLEASE MMS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21077">
        <property type="entry name" value="EME1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21292">
        <property type="entry name" value="EME1-MUS81_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="147"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="234"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="285"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="357"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="468"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="244"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="285"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="470"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="487"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGY47890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="822" mass="90954" checksum="476338FC855B0048" modified="2018-09-12" version="1">MNDSYTYSSDVEVHVIPQPSKPATWHRNVDIEDNDDDDDDDDASPRVPLATIDHDSTPRRQPRTTSGIGIGTPLFLLSSPAASPVQFGTWEGVGMDRGKGKGKGKGKEVVQIDLLDESSDEDQGITQGAMKVLSSESSSDDGVAIVVQGSSRRPLQRTAPLPVRPPTSDEDGELPDPATLGFAPSRSTYLGPTVGPSRAGPAASTSSVSPSFILRSRLGMHPTDANYLDNLHQQIKTKKKARRPPVPNPFRDAPPLPPALAARRSGSGSAILSMLDHLPVYHKAKSSTTTKRKGKRVGIYDDDDDEDGSATTTDSSEIDETCASFRGPPRQFIMNSEGGPVVELDWREETRVWEKEMREEMAGKKKRKKERERRKSEEGKRERAQAKEREKAVAVAVAGNAKRKASTLSLDERETIKANKAAEKERKAVEKARLAKEKAALVKANNLRAGDKATTVMELTIHLSGTDFDQFSDTEDEEEEDGGEGGKKKKKAKKGKKSEQPQWMNITKLLQTRMNPQGCVVEAPETPRRDIGCEGTIRWTRWCDRRWNMEKNIFEPLGEGNELVVEEDSRLIYISCLLFECVPSSALQLSTQIADKTLLRNLQKIQERIGAHSQIILMHYGLNSLYREMENAKQAAYREDTRLRLDNVPLAGPSAPRSVGIGEKQPEKEVIQMELLRVQSQSRCFMIAVNSVEEAVDWIEQLTYDVSQKPYQRQKNMHIAALGTGEEKFASGSNLEDTYVKMLATLKSVTEPVAKAIVGHYPTIKELYDGWAKLPSGERKNMLVGIGRGSNVTGVATNRTIGAKLSETIYKIFSSEDPSMFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M864</accession>
    <name>A0A2X0M864_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">60S ribosomal export protein NMD3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C001g00698</name>
        <name evidence="12" type="ORF">BQ5605_C001G00698</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NMD3 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY48822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M864"/>
    <dbReference type="STRING" id="796604.A0A2X0M864"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048899">
        <property type="entry name" value="NMD_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048898">
        <property type="entry name" value="OB_NMD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746:SF2">
        <property type="entry name" value="60S RIBOSOMAL EXPORT PROTEIN NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21193">
        <property type="entry name" value="NMD_SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21192">
        <property type="entry name" value="OB_NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nmd3 N-terminal" evidence="9">
        <location>
            <begin position="22"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Nmd3 N-terminal" evidence="9">
        <location>
            <begin position="146"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 SH3" evidence="11">
        <location>
            <begin position="276"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 OB-fold" evidence="10">
        <location>
            <begin position="341"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="512"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="523"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY48822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="567" mass="63165" checksum="3DD18C8F015421FE" modified="2018-09-12" version="1">MSTNAAGVVYVAPAQQTAYVLCADCGTPIEPNNANLCVNCLRNAVDITEGIPKQTSINFCKGCDRYLSPPTTWTICQLESRELLAICLRKLKGLSKVRLIDAGFIWTEPHSRRLRVKLTIQKEVINISAFSSPYEPPADLMAISPQVFTSTILQQIFEVEYVVQGAQCPECTRLAAKNTWRALVQVRQKVDHKRTFLYLEQLILKHNADKDTISVQEVKDGLNFFYSTKQHALKMVDFLGAIAPVRAKTSEQLISQDIQNSTTNSKLTYSVEIIPICKDDVVCLPRKVALAMSNISQLVVCHRVGNQIYLIDPLTLTLGDISSSVYWRAPFSPLADITQATEFIVLDIEPTSHPPKTAKGGRFLLADAQVSPVGGSMNSDVIFHTRTHLGAVLKPGDTVLGYMLGSSNFNNDAWETMDQSRAPEVILVRKTYPNRRKKSKARGWKLKSMVKEVGGASLEGADTIGLGREKSEGRKSRGAGAAEHAKAEADYERFLRDIEEDEEMRQTLRLFKDPKAVQQQENEMIEESDFEDAEDDFPEINVDDLLDDMEGLNIEPDEEDDAGMESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M879</accession>
    <name>A0A2X0M879_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C001g00737 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C001g00737</name>
        <name evidence="8" type="ORF">BQ5605_C001G00737</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY49096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M879"/>
    <dbReference type="STRING" id="796604.A0A2X0M879"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328:SF3">
        <property type="entry name" value="PROTEIN MAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328">
        <property type="entry name" value="PROTEIN MAX MYC-ASSOCIATED FACTOR X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="60"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="176"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY49096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="370" mass="39475" checksum="4F5568B7FF96EC44" modified="2018-09-12" version="1">MGIASDITTYGHSPDEDDVSASLYDDGDGDGDDDLSNLVALPTKRKSSSAASRKGPQGADKRASHNAIERARRESLNGRFMTLAEALPSMAKVKRPSKSVIVNKALDFVFEAQVKESALTKENAELRREVNELRQQLGLPPLPPSNASVNKKHSVISRHSSSASVTFGSPLDLTNSASQFDNRTGSSIGGSPATSSRPDSPAIKSEQSMAAFQTSSLTYPMAMPITTSMFANAGSPTNSLVDPSDSFSASSVSASSQMSSSAPVHAVATSPFALHQQQMATMSNVHAQNMLPAAFGYLSPEMLQAQQQQQQHAHAQQQQQHQQQLLFAAALQQQQQQLQQQHPHAGSFDLYGINSALLNNTWAAGYAGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M8Z2</accession>
    <name>A0A2X0M8Z2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g04095 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g04095</name>
        <name evidence="2" type="ORF">BQ5605_C006G04095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY55938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M8Z2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY55938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="316" mass="33922" checksum="F17EBED629F6E435" modified="2018-09-12" version="1">MNMTIAELLAFDVDPADASLHIELSKDEPTQYSTLSSTRGPTSSCSTRGRPMESSDPSRGEAGVGVSNTEEGRSTAHSCVLKGLVQSMGPSRCEDMAGTTRSFCWTGGDQMARALTTHEDPEQYGALAQRYPHFGLLDGGAVTTATTLEIGSLVCFSLKRGMHSLSCDQTVYGEEALSIGIGLVCYSAIHLQQSDNSALASLVVLSNIVVQELCLIKKACSSIHLIDGTMPFRMIDGRQVIESLGPPKITYSSTTDLTSLYPDERIISTSAHAEQRFASLRSVPGLRDAAGRTSTSRKCHGGYKKLKFSKPILTMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M906</accession>
    <name>A0A2X0M906_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="23">BQ5605_C006g03813 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">BQ5605_C006g03813</name>
        <name evidence="23" type="ORF">BQ5605_C006G03813</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY53887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0229">DNA integration</keyword>
    <keyword evidence="18" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="16" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="15" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="16" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="17" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="22">
        <location>
            <begin position="504"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="761"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1123"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1308"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="1123"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="1312"/>
            <end position="1325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="SGY53887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1353" mass="150116" checksum="19D3C8B4012293AB" modified="2018-09-12" version="1">MSSTGESDFPNGSGNRLYLKDTQGYKSWSQRPFINLRANKVWDVPPPALAGLGGGSGSAHSDASPRLTSVRVADKVAEYRERAIRRNDLACKYIANSIFEEQMSHLIHLTSAYKMWDTLRGLHSHGRPSRTMDLLNTLAQPYSGDIPFKEFVNKVKIAMTDFQNLGAPLPHWLFAGMLVRSLPAQYDSIVGNLASDIDIHMDWNTFYPKLLMNVEMADSRNKQKESLSARIVDNTSLVARISTTAQKDYSKSCCSRCKALGHERGWRLCPSRNKDASAPASSDSNLNVAAIGVDESALMTYTFPYSRTMPRFPWIIDSGAKVHCVGDKSVLSDVVSEPLKISVANQSQIESPDHGSVMFLTSYGARITIKRVYYMPGAQCGFISIDRLLESMTYAVGPQSNLIFSIRGKSILRSLPGRGFVMDAAPVQPIMSSSPPSMVGANCLTGTCTLMEAHRKLGHQSPAAIVLAVKSGAITGITLKDKKVTPCFSCIQAKSKQSPFSNKSTEAPHALYRVFIDLGFVKHPNHHGNTIYLAIVDQYSTAKWTIVLKDKRAETIIEAWSKVQAESERQTGQKIKRVRSDNGREFDNSLFRALLEKQGIIVEFTAPYTPEQNGQVERLNGSLMGLVRSMLLDSGLPMRFWSDALAVATFVLNRRPHPRIQGKTAIEVLLGKKPSLAHLQPFGSTAFVHVPKERRSKLAPRSIQGVFIGYSGEYNYRVWVQSSKQVYVSRHVTFLETPSVVTLSQDHADASDPYLAVVPCKDDDKDDNNGLNDGPDNYHDAEEPLDGEAEVALAPREGYAIIRTGPNPGQFENVDPSNILPASSRRRPQPPENILPIILAIMVDVLDTPPRFHDKLSARPEAFARGTMEGDRTFGLVLVNYYCLILSIVLEHRCTRCFQFFFDNDQDTMSEPHKDAPPRWKLHAPSYLCRTDRTLSGLRLFWSRNDQYFKKEKIETDVDKIDIIGQLLLDPELKVWYSSDAASHVKKKYGVFQRDLTLRALPSDYMWQHYRRLDNLQQTGDYREFSTAARDLQLELGVSLVSDTQLVRMLLLHMDEELSQRLRLSEVIKGTGLSPDELDASIVKADSTASSAVFDYQTFDAEARRLWQVISATRASVKATAQASARTVRSTPTLPPLSSKTRAPPMTDRERAFLRSNQGCFKCRKINAGHFKDTCTTWATSACKVPAGWRQGPVSPEQVASLSDAVDEIDDKGEELHCLCDDEYDNGTDDERCEPISLSVKLTIEDGPALRALVDTGASAIRRSPQLSGEVESQTEVIYFSVPIRRSPRLSGEVESQTEVMRRKLRNKKGARAGIGPAAGEIAGALRQSRASKSPPQGGGLAGVHPNPPAPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M9C2</accession>
    <name>A0A2X0M9C2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C004g02960 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C004g02960</name>
        <name evidence="8" type="ORF">BQ5605_C004G02960</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY69108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0M9C2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000102">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000001">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF13">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039073">
        <property type="entry name" value="BRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="369"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="598"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="1230"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="218"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY69108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1826" mass="201034" checksum="4E843589D25A519C" modified="2018-09-12" version="1">MSSAPEALLASLQDVLTLQRSCSPSMTFDTALALAQSASTSFTSSRSNGATHNATAKVEPQIPSLQELDHDPWSEIHALELIHLSTSNGEHAQSASTSISSSSGAEAGARSLDWLRASLPTQQDYVSALDILLSPSGDQDVATSLLEIYGFEGIDSVGQAIENRKTIQQQANIFAVNDSGIPACSVTTIPAHHHQPPFPTQSQFSVPKERTPQAQITFQSKSDLEQAKRERKLRHKLARGQHGPDGGEPNGGIDLEKWERLRQETLARGPGPLASSDREWEEPIRYPNVYLAPGAQAAAHGLGGQKLILPVGTTRNDRGEYEEIMIPAPDPVPFRFNENPVPISAMDAWGKRTFHAYASLNRLQSIVFPVAYGTNENMLVCAPTGAGKTDVALLAILRCLSGLANTPLVGNAKPTLPPASSYKIIYVAPLKALAAEITLKFAKRLGWAGVKVRELTGDMKLTKKEVDETGVIVTTPEKWDVVTRKGAGAGDGDVADKVKLLIIDEVHLLHEDRGAVVESIVARTLRQVESSQSLIRIVGLSATLPNYVDVADFLRVNRHTGLFYFDASFRPVPLEQHFLGVRGKAGTPASRAGLDNAAFEKVAELLKQGHQVMVFVHARKDTVKTAQTFQEKAQGEGIRDLLDPNENEKWPGFKRDLAASRNREMKELAAQGFGIHHAGMLRSDRNIAERMFEANVTKVLCCTATLAWGVNLPAYAVVIKGTQIYDAGKGSFVDLGILDVLQIFGRAGRPQYESQGVGYICTSYDKLDHYVSAITQQHPIESKFVEGLVDSLNAEISLGTVTNMDEGVRWLGYSYLFVRMRKNPLVYGMLATEVADDPLLGSKRLTLISNSAKRLVETQMVRWDKDLGQLEPTDLGRIASKYYIRNASIEIFNTLFRPKMSEADVLALIASSVEFNQIQVRENEIEELTRLMETVAPCQVKGGTQSSSGKVNILLQAYVSRAFIEDFALVSDSGYVSQNAGRIVRALLEIAMAKRWAPVTLVLMSMSKAIEKRLWPFSHPLAQFDLPSDLLYNIERWADDVLLSEVASMSDADFGTLIHQNERLGGLATKAAKQFPSLGISYSLRPVAHDLLRVRLELRRSFEWSDKHHGTVEAFWVWIEDEEGLSILGLARVVVRPTTNVLVQEFVVPVSSVPKALHARVVSDRWIGSEEVQTIALKHLSMPPSPPPHLPLLDLPLLSCRDAFGKDDKALQAYANDTPVFDPVQTQSFHSFHHSASNALLCAPSAHSRGVVLEMAIWRAFRVNPQARIIFLTPRKALARQVSIRIRHLFSHLSDVSTVLLMHSKDFGTLPQAGGLIAITSPTPLLSHLTNDKSLFQSLDLVVAHDLHALDGPYELVLTRLRWENSTTRVVGSTSSLADATSLAHWLGVPEHAIYNFSPSTRTSSLTTSFQSFTTPHSIGLIRSMVRPAYAAMRTSTGSTICFVPSRAMCRSVAADLITQTASDIEQTFVRHDAMEMIEAYASSFADPTLHEALNHGIAVYHPGLTIDEQRLALMLFSQGAVKVLISPHDACWTLPLQANLVLVLGAQYAVPRPSEPTERDIRDYPLEEIVQMQSLAVANRSTTSAEFIILCQAEQAKLYGRYLDQGLPLESALLDQDDTKGNSLIQMMWSDLAQRQLISNRQDVVDALSWTFMARRIEDNPSYYNDRGQEAESLLSRIADQQIVDRLERAGLVHAKGKSEIGITEMGKLLAGALVAQVESLQQIELDRLVDIAMAMKHLSGDISKDAEAVRTFQQRLARPIRDMIGPEPSDAETQDTSDAMLHYRRRVLLAAFIAGKAPRYDDTLVSEQARLVQSLLGAHKRHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M9Y7</accession>
    <name>A0A2X0M9Y7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C004g03140 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C004g03140</name>
        <name evidence="3" type="ORF">BQ5605_C004G03140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY70330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M9Y7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF463">
        <property type="entry name" value="REVERSE TRANSCRIPTASE TY1_COPIA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="488"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY70330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1008" mass="109923" checksum="A9E49ECE25139D80" modified="2018-09-12" version="1">MDSSPASPSAPRDPSSPESSIGEQIATLQAQLTALQASQPAAAAATPAVTATASKVVFPKHARLDGPKSFTNWLRQLRLALPNQVRGYVLDSVIPPTWTANQLATRDDAAREIIVGSIDSADVLATLDAIPSDDLSAPRIFAALKARFAPDDATRTLELFACLWDFRKMPASVEAYDTWLREYMSIAQEIRDTKTSLNDVLATHVLAMVPSCLDSFRLTFTDEQRNRRDLPKLTTLTDRICIQLCLAGLSTSHSAMNATFLDDNFPGLPVTTPVDADNTDRQFVIPADTPAPAVKTRTPLVRSAHMDVSSSLDDSAMSAVDVAPGYTGGSLLNSTGTRSSSSPSLSPFSSPATSSAREPSLNDSDDPLDLLSSNTAVCLNLLDVHRSDDDTLETQAPAVDPVEQPSDDDSPDEIDFLSRHHRTFIATENDNPTLEAIEPVKSITSDPQTWHEAMSSDERDIWAQAAAAEFTAMRDDFKVFTIEPCSALPPGATIITSKFVWKTKRDARGDVTGQKARLVAQGNRQRDGIDFSETFAPVARFSSIRCLLALAAANGYHLDHDIWMTTPQGFDFPSNKVLRLRRSIYGLKQAGRIWNCHIDTSLRNLGYKATGTDHCIYSRIDDQQRPHYIALYVDDLLIVSPGLDEIKCVISGLEQRYGIKRLGSAEYILGIQIRHLDDGSIALSQEHYIMDVLARFHFDTTTRGTTVPMTPGLSLTAIPGQGTERIRSWYLQAIGSLLCISLGTRPDIAFAVSYLSWFANNPGRRHWIAVKHVLRYLCTMYHNELLYARGPAKVTGVVGYSDANWGACVDTSISTMGYVFYLAGAAVSWSSKRQTRVADSTTDAEYLALSHAGKEAIYLTQLLSELHVSPIAAAHIFTDNKATAAVAHDPVRTSGTRHIRLRKHFVRDMVNRGDISLSHVGTANMVADVFTKALGPKIFGTHCYALGLRTRHPRLKSTWRSRGGGGGAIGSAPRLAGCGLGARVSGLRLLSRRQQAIARMTGRDAGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MAG6</accession>
    <name>A0A2X0MAG6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">serine C-palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">BQ5605_C005g03322</name>
        <name evidence="20" type="ORF">BQ5605_C005G03322</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-serine + hexadecanoyl-CoA + H(+) = 3-oxosphinganine + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:14761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:58299"/>
            <dbReference type="EC" id="2.3.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="7"/>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY73855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MAG6"/>
    <dbReference type="STRING" id="796604.A0A2X0MAG6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017059">
        <property type="term" value="C:serine palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000047">
        <property type="entry name" value="serine palmitoyltransferase 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF3">
        <property type="entry name" value="LD36009P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="19">
        <location>
            <begin position="289"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="SGY73855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="705" mass="77707" checksum="E869C90BE09A19F7" modified="2018-09-12" version="1">MPVRGAAASPPSHYPRKPTPTTGIDGNRMDAASYLTQVQSRASVRTRSSSNGSSSLISYASTLPQFDHHGRKRSSSDSAGSDDSNESTRSLTWRGLNTSMPLSSAVSATRPVTRAFDVDFVPNPQDPYSLRHSEYGYDIDPAHRTISQYTPGDDLSASEEEPSVLVYLFTYVSCQSLAYRNPLNREFQLTQIDSCLVATDALLILIGHLRDFIGKRLFPREYAHLKPSNGYAPLYSDFDSFYTRRLKLRIEDCFARPITGVAARTATILDRTPSEFFHDFTFTGETTQALNISSYNYLGFAQTRGPCADQAEEMVKTLGVTAAGGRNDVGTSDFHVQAERLVAAFLGTEDAMIVSMGFATNSTSLPALLTKGCLVISDELNHSSIRFGARLSGAMVRQYKHNNMKDLEQLLRECVSQGQPRTHRPWKKIMVIVEGLYSMEGTLVDLPVILQLKEKYKFYFYIDEAHSIGALGPRGRGVCDYFGVDPKRIDILMGTFTKSFGASGGYIAGSHALINALRLTSHSQNYAEAMAPPVLSQIVTSMGSIMGPAALAYVPALAKLPPHLMDGREGQDRLRRLAFNCRYLSGGLKKLGFIVYGHRDSPIVPLLLFSPGKMGSFSRMMLERHKIVVVVVAYPATPLVASRVRFCLSSAHTKEDLDRILRATDEVGGILGLKLSPKGPRMDVEDVIRTGVQMVRDSELEPYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MAR4</accession>
    <name>A0A2X0MAR4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C005g03485 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C005g03485</name>
        <name evidence="2" type="ORF">BQ5605_C005G03485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY76368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MAR4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY76368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="198" mass="20908" checksum="0493D3544EBC2CDD" modified="2018-09-12" version="1">MGQKELKNRICLGQTPRQQNTRSTICSPLATQSSGRACGSPNTSVAIKTSLEAASGPTAGRRCSTLSPIKEYTDQGSIVLEPKVGQSCTSPHAVSDASSPSPSPPSANTSRTTSPSPSLRSEDGVAKVRLPSTRPSVIHSRSAPNTVEMIRRCTEVLAPKCESHPQQPADNDREILGKSTTPPKPINLRRSTSSSALH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MBX7</accession>
    <name>A0A2X0MBX7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Succinate dehydrogenase assembly factor 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C004g02739</name>
        <name evidence="4" type="ORF">BQ5605_C004G02739</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SDHAF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY67061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MBX7"/>
    <dbReference type="STRING" id="796604.A0A2X0MBX7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012875">
        <property type="entry name" value="SDHF4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28524">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28524:SF3">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07896">
        <property type="entry name" value="DUF1674"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="39"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY67061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="150" mass="16483" checksum="78C182843D98F15F" modified="2018-09-12" version="1">MTLRSSAVSLARGLASSSSSSSSLPFRWTSIQNVTFQPRHFSTSHAPPNSFSRPSPPLLPRADQKEFEDLQRRVNAPASQQAQQDLEAQAELAKTVTGTEEDLTMHPDYRKTPEPTFQGDTNPETGEVGGPKREPLVHGDWSYGGRATDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MD16</accession>
    <name>A0A2X0MD16_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C004g03089 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C004g03089</name>
        <name evidence="2" type="ORF">BQ5605_C004G03089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY70001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MD16"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="269"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY70001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="335" mass="37523" checksum="703694A27936CDB1" modified="2018-09-12" version="1">MDYQWAKKRGQVAGNKSKLHRLRRKTSALFPRHSTTVSDIVNPLLYTPSTETFGIVPVVQSRTAQMCFLIEPYHVERGTLRLEPVKWSPRNLLQNNPPAIQHMQSRLPTDRKLRHDWLAERRVLDSLYSPQNFRMFEITELWNKYANGLDIFYKMPEHINTWAPRWSSQANAPATMNMGGNDVRVIQALLTDPSRGRDVSMLAAKSHYSVTKFDRPDPARGKLGLFLTFGSASDQSIVQLHKPPVLGRLTEVEVDSSDPPTSSIRPFVASASSDAGSSADLGTSSALTRAGTTKGARHCRLCGKTACRRKGSKLSDDGSTRWIRTTHNHEGSVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MDQ9</accession>
    <name>A0A2X0MDQ9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C004g03057 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C004g03057</name>
        <name evidence="1" type="ORF">BQ5605_C004G03057</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY69759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MDQ9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY69759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="61" mass="6438" checksum="4668DB20BA64ECA0" modified="2018-09-12" version="1">MADYPVFQCLHPCRSAFAFPLAMAPPTAPCFFLLVLGRAEAAVHNPLGVFSNALASGLFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MDZ0</accession>
    <name>A0A2X0MDZ0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="9">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">BQ5605_C009g05624</name>
        <name evidence="15" type="ORF">BQ5605_C009G05624</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 17">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="9"/>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY83222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MDZ0"/>
    <dbReference type="STRING" id="796604.A0A2X0MDZ0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17932">
        <property type="entry name" value="DEXQc_UvrD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18807">
        <property type="entry name" value="SF1_C_UvrD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.486.10">
        <property type="entry name" value="PCRA, domain 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070:SF2">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE SRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="13">
        <location>
            <begin position="117"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="14">
        <location>
            <begin position="452"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="40"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="761"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1022"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1120"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="771"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1022"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1048"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1133"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="138"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SGY83222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1155" mass="125242" checksum="FBDAFC3928BEA5E9" modified="2018-09-12" version="1">MLSVRMPSISPRVSLSLNATTLQSFSFGECDTIPMPTAIDDEDEAALIAAAEQEGDSDSDQEQAQDEPPWDQVGDVLDPRGDDSTATTTPTQSKSNRTSLKQSTLTFQQRQPQEYLVGLNTTQLAAVTADLGSLQILAGPGSGKTKVLTSRVAYLLQHYKIQPQHLVVSVLASALATHLAAVSQLNQSPRGHHRVTFTNKAANEMKTRLALLVDKETVDSIIMGTFVCVRYLRRYGRRIGIRNDFTVADRDDCLAIAKRAVVTAKCPEDLRKELNPKYLLDVITKCKATGLSPRAYRAQGDSTDYFKAREKTDAIANIYQVYEDELAKDNALDFDDLLVRGLELVRKHKSIVSDIQSVLIDEFQDTNAIQYDFVTTIARGCQSLTIVGDPDQSIYGWRNAEVGNLERMVNDFKPVKQIFLEENYRSTGAILGAALAVVRQGTKTPFNRGMTGVTKLMGYVWEFSDSNRIQKGLKATHGAGSSVVLHCASNAYEEATFIAAQIKHLVAHTGNLVDYGDVAVLLRYGALSRNIEVALQKTGIPSRMVGGHKFFDRAEVKDMISYLQLVDNPSYTAAFVRVVNTPLRGIGDKTIRDIIAQARLKNLSAFELCNKLANGSGQVSLTSKQKDGIKFFVGLILELQRKAHEGATVSDLIDALTVSLNYQAHLEKSQGPDAKDRWENVEELKAFATVVAEEHPEGVDDLVLPEDEDFEEVAIPAKGKAEDADDDASTSTRLAPVLTGTKTDNPLRTFLAVSMLATDSETNEVKENSKQRAGSTSEPEQKVTLSTCHAAKGLEWPIIFVPACEDGIYPFYRCRKDEEIAEERRLLYVAITRAQGFCTLTHCQQRMAGADMAQRDLTPFLKSVAKTYPTLFVPKLQKIGADTRQAMAKVLGREPPDEAETARLIEEHNKTLPIDAPSESNHFGNRGLASKMSQHSANMAAYNHVRASYSSTGPAPIPAGANAGFSSALSTFQNGPNGVGSSSVTKFGMISSVGYRTSTEPAMAKSSISKPLPATNIIRVSSAGSSSSSTSSSVINSAAFKPPRPTAGRSSSAQGPISSRSAAASAHRNGPLEPPETRSSIISNAVLVGSDAEWKIKSVPTNLAERFAKGEGERLAQLRSLGLVSDETQPSKSASRTGTARAGAGEVSPKRRKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0ME40</accession>
    <name>A0A2X0ME40_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C009g05674 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C009g05674</name>
        <name evidence="2" type="ORF">BQ5605_C009G05674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY84071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0ME40"/>
    <dbReference type="STRING" id="796604.A0A2X0ME40"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090730">
        <property type="term" value="C:Las1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007174">
        <property type="entry name" value="Las1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002:SF0">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04031">
        <property type="entry name" value="Las1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY84071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="482" mass="53562" checksum="0B55A23B7CD49967" modified="2018-09-12" version="1">MIGVPRRVPWSSPDELHQVFSWLFAGDGDAAVQRYAIGRIKVWMSRGNCPHAIESTASLLELVLRDTANVGPSQRPSQHELRLAYSMALIRFVNSLVDPLQTTYYARSMASLAAQLGLPLWFVELRHAATHEDLPGIAVLRDAARQVSPDPAQALDWLYSNYWIPTLTPSSSSQTINTIPPIPIDSLQPLLTSYKTLMKRALRDASKSKQIRPDLARSYRAIQSWVAEAESMGRGRERAIEGLVEALLEVGCLVPEAKKGRQFDVRFLYRKRVTPRAPTLSAELVAIWSPLLERLDEMFEGLQDALLTRIVELLGTCSAPERVDGTTQVNPFDRSYYSTLSAWVFQLVSLTDDTSSIENLIKSLLIQANPISLTLVETLSNVNENLSKIVKPLIEVMRQSETKVASSIEVDGVEDQLAEMERRLKQMEEKVKLSETARSPGQASSLATSGHSTMKNGWTLVQSWKPCPIGASGSLDLPPFQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MEQ0</accession>
    <name>A0A2X0MEQ0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C039g11748 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C039g11748</name>
        <name evidence="1" type="ORF">BQ5605_C039G11748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000060">
        <property type="protein sequence ID" value="SGY89419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MEQ0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY89419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="113" mass="13414" checksum="68058FF13DECA763" modified="2018-09-12" version="1">MRWTLHRPLRAWRGHEQHKNFFLSTIHHLSYDNVDLFAPIPILAQETDDFINDNQNNMARMDRGQLLEGVDRQRRSTTAARKGRQSEATRTIRVLWYRRPGYYDSIPLLLPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MEQ4</accession>
    <name>A0A2X0MEQ4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C005g03389 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C005g03389</name>
        <name evidence="4" type="ORF">BQ5605_C005G03389</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY74940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MEQ4"/>
    <dbReference type="STRING" id="796604.A0A2X0MEQ4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="184"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY74940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="442" mass="49129" checksum="110235AF3325060A" modified="2018-09-12" version="1">MDTPPVRSTLAPLLFGSWLNTGHSLTSTFDNSLFTLELLWMLEHFWKHPFSRGPRWISVTLLVLLLNDSISTISNYAAIWLYTIVHFGDYAYLALQDWTVVVFLITTGVSAMVVQFFLLERAWTLCRSGLKLNAAMAIMIALVALGILVSFSNCFWTAAYVVIYKNYTERYRLVTPVTVWLTISAGCDVTIAGILLFKLNQARKEVANRAHSNLLVPLQKLMIMALESGAVTSFVAIVGLGLYLGFKTTNLPLAPGYCLGRIYALTMLFNLRVRDRLQAEAISSQAVGVSTFALRADAPTDLSKDPHEFDVERHGVMSSVVGVSTIRPDPRRGQTSRSHTVQTQTAQSQTVQTISLETAYIMHCPTTPRIGGSGIGEESDGFDADSSSIEDREPRTRRPRRVARREFASSRRSSVSIPSVDDPMLATLRYVPRQDVSPHDLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MEU1</accession>
    <name>A0A2X0MEU1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C005g03721 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C005g03721</name>
        <name evidence="3" type="ORF">BQ5605_C005G03721</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MEU1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="53"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY77768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="532" mass="58611" checksum="5EE4B3474592556E" modified="2018-09-12" version="1">MRQSPLLSGEGARTGIGPAAGEIARALRQLRASKSPPQGGGLAGARPKWTLYNGIDFTETFAPVARFSSIRSLLALAATNGLHVHQADIDKAYLHGDLDHDICMTAPRGFDLPGDKVLRLRRSIYGLKQAGRIWNRHIDASLRDLGYTATGTDHCVYSRLDDRQRPHYIALYVDDLLMISPDLAEIERVISGLEQRYGVKRLGPAEYILGIQIRRLDDGSIALSQERYIMDVLARFHFDTTTRGTTVPMTPGLSLTAIPGQATERIRSWYLQAIGSLLYISLGTRPDIAFAVSYLARFANNPGHRHWIAVKHIFRYLRATYRDELVYARGEARITGVVGYSDANWGACVDTSISTMGYVFYIAGSAVSWSSKRQSRVADSTTDAEYLALSHAGKEGIYLSQLLEELHVQPVAPAHIFTDNEAAAAVARDPVRVTGTRHIRLREHFVRDMVNRGDISLSHVGTSDMVADIFTKALGPKVFSTHCYALGLRTRHPRLGSASHSRGGGVKSPLSARQRRLGRRAHPLARPLAVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MF22</accession>
    <name>A0A2X0MF22_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C005g03340 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C005g03340</name>
        <name evidence="1" type="ORF">BQ5605_C005G03340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY74089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MF22"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY74089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="56" mass="6122" checksum="EF00F6EFD9601AB4" modified="2018-09-12" version="1">MILKPYAQIQMAYLSIACNSVVTGAFAEITDRVALGPLVRTPEPAFDRTSYTLGEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MFE1</accession>
    <name>A0A2X0MFE1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C036g11478 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C036g11478</name>
        <name evidence="2" type="ORF">BQ5605_C036G11478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000063">
        <property type="protein sequence ID" value="SGY95203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MFE1"/>
    <dbReference type="STRING" id="796604.A0A2X0MFE1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY95203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="373" mass="40981" checksum="EDCCAD006E20F0C2" modified="2018-09-12" version="1">MRVRNGAFIGNLFRSARLFSEAWRCAPTVVFSPLSTPLSLQSTHGWITRSSISYLVASVLPQGTDPHAEKTQRISKMATTTVNSGSATHRGLMGDLYGNVDATNWGTAKDRLQRVLEGDGRFKHVTTELSVGPEPEQSEFTRTLGGSTVADVATFRTQLRNYRHDVDDLDQALAQARNILFVCLGEATFARIADQPTHELWAALDKDLGAASHDFERSAKLDALFQYQAYVDGDPLDPWLSRFNRLFIDLNAAHVSRDKAYQRAKIDGVKYTQAEFDKWVPPPALSEGIRMDLLKARMPRPIVTVIDALGPIPSLSDVEGAIRRAAMSRSSGTDVAEALAAKTQGRRRRPARSSGKPKSSFVSASKVPGLVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MFL2</accession>
    <name>A0A2X0MFL2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C014g07577 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C014g07577</name>
        <name evidence="3" type="ORF">BQ5605_C014G07577</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY19163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MFL2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF3">
        <property type="entry name" value="GERMINAL-CENTER ASSOCIATED NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC3/GANP/THP3 conserved" evidence="2">
        <location>
            <begin position="206"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="607"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="670"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="676"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="726"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY19163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1398" mass="152614" checksum="9687F3C6D23FDEC4" modified="2018-09-12" version="1">MTSPFGGGAFGAGASGGDGGAFGGGSNHVTNPFGASSTGVFGAAAPSSGVFGTAASTSTSPWAWGASTLASDNNRNESASNISGAPLSVFGSFATPASTSAAPPASAFAKLPPPRQLDRPPPPSSVATPPPPRDPNQISTLEVLGEDSDARKQRFESSLANNRYLELKPLREAQRLRDIKNGLIPDPLKPMRLDQATDFLGTCQDMCPAWEREEREYQNNVDALERYPGTTRIDPARAVKAFHRPAAGNEQPLPSDVRPPPVLKKTLDYLFHHLLPTAPLHVTHPFLRDRTRSIRQDLTMQNIRGEAAIECNERIARYHVLALGTLREQSSFSESQELEQLRKVLKSLNEFYDDARLANPPIPAPNEAEFRAYNILTHLRDPDIIWSCELLPPRVFDEPRLQIALRLHALVQRSNIPRGERASLNAASRFFKLLANQEVPYLFACILSTHFDQIRKNALETMKNAYMQQHSGFPARTLVKVLGCDDEEEVESICSQLGIGAKKEESGELVVMLHKAAVIKNVTLQQRVSQRLVEAKRGTTTYQAVIDGTAYISAAVQPLPSAFSPAVFRAPAAPAPKRPAPTPAAPPTLLTSVPQVSPFDIIKPAPVEPKMPSFQTSTPLAFSSAQASPSTTPPTPSLNPVAPSFVPNFAANPKLATTAPNPFASASTASATSAFAPPPQPNAFFAPPPQRTALKQGSGQLPAPKAFSFESAPQPAPVVEPRKAAEPSPASKPSPEVVKSVPTKKPKSVQAPALLPKSPSPPKLAKVDQGPLIASLSKIFVDELLTSAARSCAQHAAEQALEDYWDMIAHDEQRTMEYVAAKLAADLLEDHARRVTASELVRAKRQRRMTRKVWNSWRLRTMLSLDAKERDRERRKRFEENVREITASVGVGNMAWDQEEDYSFDGALDLSTLSLGLPDLDAPSASSVQADRAFADQIYTAQARRDKLWRSGTMLHTLAQHVDSLVPTQQTTRQAWAALVSTTSTTSTFATWLARKFDLSDLELTSTIDMPHVDLLVEMVADENDPRQETLDDVGLILLDCTEELAASDLYAAFQRVHRLVEAANEVSRFKPSLLITCCPSTTPALEEQVELKQKLLDELKINSLRDGLQGVDVWIARLDDAEEDFDKLTRTALPTLAIRVDRAKRPLVDFVAPLLRSWSDARAFAFSQRCSTDNPIIACNILLSSLSLILSSAKKTATANSPFHPIESLPLLPTTFSTSFRSRIQSYLSDKRLEVVGPSPLLNSALSEFPPVTDATLARLLFDHLENRVLSSVEGYFIQQDTYDYELRRTRARLAERVFTLPRDDDEISSEPIKENIAIASTTLTSKQKGKRKASTSLELALSKNKKTVLEPNGTTPSTTVDRLSALEKIMKEAKGLLTMGGGTLDTGSNSSRVSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MG05</accession>
    <name>A0A2X0MG05_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C035g11406 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C035g11406</name>
        <name evidence="8" type="ORF">BQ5605_C035G11406</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000064">
        <property type="protein sequence ID" value="SGY97477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MG05"/>
    <dbReference type="STRING" id="796604.A0A2X0MG05"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071074">
        <property type="term" value="F:eukaryotic initiation factor eIF2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11561">
        <property type="entry name" value="W2_eIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000031">
        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.350:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.170:FF:000002">
        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF7">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="7">
        <location>
            <begin position="244"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="145"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY97477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="400" mass="44638" checksum="C4ACB13508662EB3" modified="2018-09-12" version="1">MAAIVNIRRDVDDKFYRYKMPSLLTKIEGRGNGIKTVFPNMADVARALNRPSSYPTKFFGCELGAQATFNDETERYIVNGAHETNRLRDLLDVFIDKFVLCASCKNPETELIITKDEFILRDCKACGKRGNVDMRHKLTTFILKNPPKSKKAGGRSNKKAVAGADSIAGQPGDDVGDGESDDELTKKIEAGAAEMLSDEQAKALIAQREKEDKWSIDTSKEAVAARVNQLDSKLQNSLVIDDDDDEAGGPYDTFGDWVRENRGSVSDAEVYKKAEEMSIAKKHKTLLVLIQALFTDKIVEEIDAHLPLFFKMTTSEKHQKSLLGGVERLVGETYPDHIPDVPKILMKFYQADVLEEEVVTHWGTHASGKYVDKKISKKVRKAAGPFVEWLAEAESDEESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MG38</accession>
    <name>A0A2X0MG38_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C005g03720 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C005g03720</name>
        <name evidence="7" type="ORF">BQ5605_C005G03720</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MG38"/>
    <dbReference type="STRING" id="796604.A0A2X0MG38"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF28">
        <property type="entry name" value="TRANSPOSON-ENCODED PROTEIN WITH RIBONUCLEASE H-LIKE AND RETROVIRUS ZINC FINGER-LIKE DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="6">
        <location>
            <begin position="221"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="677"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY77761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="701" mass="76772" checksum="29A46F19492B0620" modified="2018-09-12" version="1">MDDTSPPLATGVHPTFPADQLAALTSLLSGLTAAASGTVTTTTSSSTTRPAFPKHARLDGPKTFANWTRQLRLCLADDIRSYVLDGIVPVDWTPSQRSARDVVARELLANSIDSAEVSAVLDAIPTADLTAPKIYSTLKSRYAPDDATRTLELFSRLWSFRPMPGTVGEFDGWIMEFKAIAQEIIDTKTTINDVLATLLLAIAHPSLESFKASFTDEQRTQRSLPAIDSLADRMRVQLRSTNVPSTQSALLASSSSRRKLWAYAIGHKSEVFSVFKTWLAEVELETGATLKVLRTDNGGEYCSRAFTDFCKVRGTRRQYSIPRTPQQNGRAERVNRSIVEGILALLADAHLPKTFWEEAAAYFVYCKNLVQHSALDKATPNSVWQGGRTTASALHPFGCAAWLTVAPELRSKLDPKAVRVLFTGYDLASKAFRFYDTTTKKVTLGRNATFVDTEFPGLCGDSAEPDDDTHFASAPFADPQTTVKSWTPLPQAALDPMDTQPPDFSTYREPASAEESPDELDLIGRHSRNESPDEIDFLTRHHRAFIATDDDTSDTEAIEPVKSITSDPQTWREAMSGDKREVWAKAAADEFNSMRDNFKVFTIDDRSTVPAGATIVSSKFVWKTKRNALGEITGHKARLVAQGNRQQVVRGKLRNRKGARTGIGPAAGEIARALRQLRASKSPPQGGGLAGARPSPLAPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHE8</accession>
    <name>A0A2X0MHE8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C011g06237 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C011g06237</name>
        <name evidence="1" type="ORF">BQ5605_C011G06237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY11692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHE8"/>
    <dbReference type="STRING" id="796604.A0A2X0MHE8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY11692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="166" mass="17942" checksum="5AA04AFB698A4AD7" modified="2018-09-12" version="1">MVYSDASFADDPESRRSVGAYASMLAGGVISWQSKQQSMIATSTTEAEILSASSATREAIWLRRLAGDVGIPQAQPTIIQEDNAACIQIAKDPVNHMRTKHFDIAHLFVRERVASGEVELEYCPTHVNAADIMTKPLGFQRFDQLCALLGMVSLVSLTGGSVRSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHM0</accession>
    <name>A0A2X0MHM0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C031g10898 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C031g10898</name>
        <name evidence="1" type="ORF">BQ5605_C031G10898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000068">
        <property type="protein sequence ID" value="SGZ05880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHM0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ05880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="62" mass="7206" checksum="98EF59EA81774836" modified="2018-09-12" version="1">MLGHNKTGWRPLKTVYLSSPWPSKPTFCPPFFFFFFCMKLIANLQDERTPYGTKGDAAQYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHR6</accession>
    <name>A0A2X0MHR6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C009g05601 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C009g05601</name>
        <name evidence="8" type="ORF">BQ5605_C009G05601</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY82865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHR6"/>
    <dbReference type="STRING" id="796604.A0A2X0MHR6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039182">
        <property type="entry name" value="Pop1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055079">
        <property type="entry name" value="POP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009723">
        <property type="entry name" value="Pop1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012590">
        <property type="entry name" value="POPLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731:SF3">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22770">
        <property type="entry name" value="POP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06978">
        <property type="entry name" value="POP1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08170">
        <property type="entry name" value="POPLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pop1 N-terminal" evidence="5">
        <location>
            <begin position="84"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Pop1 N-terminal" evidence="5">
        <location>
            <begin position="168"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="POPLD" evidence="6">
        <location>
            <begin position="525"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="POP1 C-terminal" evidence="7">
        <location>
            <begin position="785"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="662"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="758"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="35"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="769"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY82865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="857" mass="94643" checksum="19A4B1108B6BC91E" modified="2018-09-12" version="1">MASKRPNDESSDSVAPRRDYKRQRLQQQRTINVQRAPTSASRSGAPAAAATTVRPPRTTAAPRAGGSAARGNDQLPPTIDVDKFAQARSFEIEAMRRAIKSAKEANTQRAFQSLPRHLRRRAASHNVRRLPTRLRKRALAEVPKDAAKPKKVTRKMLGPRRRLRGRSKAAALLKRQRGKLWLETHVWHAKRTHMTTRWGHRLAIRPTEKAFRPSYRASVHGALVHDASYLQYIELTGPQDQLEHLVRLMCPLTPAGPASKRSTSGIRECSANVYPPRPHPDSLAPPPVLIGPACFIWDVAPPEATAMASSSASTSKAPIPGPPLRRLLVRLHPTFNKAVLDVVQTHLKQDPVTLSGIGARPLEQELLTFELTGQRSTEIIKACLKPTLANAPSKLDAWKRLDDKAGPAGVPTSMVLGLSVYDPRLSFPPKLAKASTNPSKPQNAKATTLLQPGTELAHVHDFWSPRVRAALRKPHYTKHDLDQRRAELLVPGTTLTAQAQDDRIPVLLVQRSLAAAPNAPEAMYGWTLIVPAGWGMAFWTSLVHTQSRVGGLQQVRQQSFEAGLATWPQDFVGTRAFDEYELAREVEDKGYWDRRPPAKRPSWEKLGTEAPWRAEVGQIVERRWKGQGFAAGARPGGSQKKLLWLVEATIARGVEHVLMERERTEGRSKTTTKQAKGKRKASASVTTTKPTGASALVDEYVKRLVEEYDSASATNEAELLLETALVQCRVTPLGRGAPEELGLVYSLDQECRDKVATGLERKQASGGSDESDDGEDEEEEDAALLCEIPSKEDVMGRITSGGFSLARGRGHAIAVVPLFLYLDLVKRDVNTSGRRRRMVVVRNRDGEVYRPCSLTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHT5</accession>
    <name>A0A2X0MHT5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C009g05442 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C009g05442</name>
        <name evidence="1" type="ORF">BQ5605_C009G05442</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY81027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHT5"/>
    <dbReference type="STRING" id="796604.A0A2X0MHT5"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY81027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="336" mass="38905" checksum="C1A35D2D82C5C0CA" modified="2018-09-12" version="1">MKQQYTYRRLAIDHAKWVFQLRAPDGCFTRHLFDIRIRLQAPNEPTPFTLSRPAPNQHRCPWIWIWWAYFCHPPPKWDHAVRKTTKLLPARWVRYFEAWALVTTLNPPELSKSQNLEQWATHVLYFPAGHGIQLSVNPTLFRGPDGEVMTPSSFVNASKRHQVFIFPLIFPKGHQKVFDLPEQRWNAWWKALRKVRRVHSDAEDTGHLLSLGSLHPGSQVASPTSPHPNNRSTSCVMCLSEAPECLVHLAVGCPFARRLCSALSPTPHPVFVDFVCPVVSRSERRLVELRVLFFHSIWKLCRRRRFSSDLLEPITETEFEGLRASIQESKGRLVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MI55</accession>
    <name>A0A2X0MI55_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C030g10809 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C030g10809</name>
        <name evidence="2" type="ORF">BQ5605_C030G10809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000069">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016023992" evidence="1">
        <location>
            <begin position="21"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ08673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="142" mass="15598" checksum="005740A0F91DEE07" modified="2018-09-12" version="1">MLLLWSRLAALALLASLASCSPVSPSPLKDVDTALSREPAHRNEQIINLTKQGISVSPTLDFNSTSILSRRFSHEVLPAIALCSPGATYSPGDKFLIKWNKSLFYTQADIWIQYSGKKASAQSELLQMHPRKGRKAAATLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MII4</accession>
    <name>A0A2X0MII4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C009g05712 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C009g05712</name>
        <name evidence="1" type="ORF">BQ5605_C009G05712</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY84684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MII4"/>
    <dbReference type="Proteomes" id="UP000249464">
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY84684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="111" mass="12860" checksum="B0305E4B2AAD4998" modified="2018-09-12" version="1">MRHSRSQWTDAATIWAGDVYDKKLKFRDLSIWYRQLVQQAFGECCLSPGALQTQRDQEGVGMPSNLKTWFNRPKLLSQYKMIVYVNGGFAPWRFPLSDRLAQDESSSRPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJU7</accession>
    <name>A0A2X0MJU7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C035g11413 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C035g11413</name>
        <name evidence="2" type="ORF">BQ5605_C035G11413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000064">
        <property type="protein sequence ID" value="SGY97559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="796604.A0A2X0MJU7"/>
    <dbReference type="Proteomes" id="UP000249464">
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR039131">
        <property type="entry name" value="NDUFAF1"/>
    </dbReference>
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        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194:SF19">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08547">
        <property type="entry name" value="CIA30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase intermediate-associated protein 30" evidence="1">
        <location>
            <begin position="16"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY97559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="253" mass="28670" checksum="FA5206B813BFF7D9" modified="2018-09-12" version="1">MAPVDLTSLGHQTLFRAPNHPWPKFDAVDDRVRGGVSTSNFTIRKEPHSHTIGVFSGHLDIMALKDVGFASQSTVFNNTKPLLLPRLCYSGLLLTILRPSDEVSVTTTPITTKKPSKPKSFVLTLKSSPPVTRPDGTRVAGISYEYAFTLGDFDGKEKQIQMEWDGFTATYRGRPDKKFAKLDPNKLYELSFMCRSNFGEQAGDFELKILELAALKNKYDKRQSRKCFDRAKQLVTRRYEAGWYRRDQGVRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MK62</accession>
    <name>A0A2X0MK62_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C021g09263 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C021g09263</name>
        <name evidence="4" type="ORF">BQ5605_C021G09263</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000083">
        <property type="protein sequence ID" value="SGZ20332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MK62"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23807">
        <property type="entry name" value="UEV_UBE2V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000026">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040206">
        <property type="entry name" value="Zds1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013941">
        <property type="entry name" value="ZDS1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28089">
        <property type="entry name" value="PROTEIN ZDS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28089:SF1">
        <property type="entry name" value="PROTEIN ZDS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08632">
        <property type="entry name" value="Zds_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01327">
        <property type="entry name" value="Zds_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
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        <location>
            <begin position="1284"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="277"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="441"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="654"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="894"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="983"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1022"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1153"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
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        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
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            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
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            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
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            <end position="520"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="680"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="736"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="894"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
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            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
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            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1093"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
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            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1157"/>
            <end position="1173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ20332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1417" mass="150185" checksum="1E440ED701ABA525" modified="2018-09-12" version="1">MHSIPSSTPPTSPPPVPTNLGRARSASRSFSEAQADLDQQRQQDSLRARAMDHLDEMPGLLTRPGVGKGIDQGGEGITPGEFRAEMETLLLRRRSLSQPANVDPDLPPPTSPTGAVHPYMHSPPGSPTSPTFSSTSKPSLSIQITKANQLGPSGHPVSPTAPTAAETGTLVRRRSSAAGTRPMLPLPSDHPLPPPISSVSSSGTPSMLTPLAAVGMPSSSAPTSSSPPPSPTALYDGRSAAHASQELFWLPASLHPELAPQEFKAFIREQTRPDNLARRTSLNSAGRGIRTGARTSSLGATLGDSVGRLDRRKSMLRGEYKPRTDDGVGEESSEGSTSEPKRLSRGKSEGAFGSFQGSRRTSGRINFDELTISDLQRLEELAARAEAEAATEGEGEGERLGRVLRRSLSLNPSNLVAQAYGSAAHSSTDLDFDGLASLSSAGGASGVSDERSASPVPGLDDDASAADSPLLVHSPGQILRRSARTKIRKAGLIGDGNGHRFGPSRRQRVTSNEWATNPSDDAQRELSFESSESLDEKGSVEWSEAASGGTTMGGPSFEGSLEGVSSSSGHQSVVSTASMAEPQYVAGLPAVPRTEVEAVELPVASVTSKPLDAPLPPTPPKFDVSLAPIASGATAVDPSSADFDWATHASNLQQAKRPPLVATPSIQAPGIPSIVRTDTSSPQQQRYSQPPAKATPPPTATKEKKSGWARLGLSVRSGAATMSSSLEEKKRGKGAQPTNSALQQPQREAFHVQDGASFASQQQQQQQEKDSGFFGGLFGKKKHDHETGNGANSGVSGMLSKPSGPPTPPLLSEVSNRMAPPPPPPTATAVQLPTGEYVNFYRLPIHVERAVYRLSHIKLANPRRPLYEQVLISNLMFWYLSIINRPTPPPVPVPVPVPLPPPGPARGASVNGVHTPDESDGSSTSGSANESPSASSVVQASTAQPTPKRGALTKSGAGNRSSPREVAIKPARYEQQNRQIDQEYLQKQQQQHQQHQQQHAPARQSQTQPVGFAPIVVDSSQVENFGSSNDGPPRSPQRSPDRSSAPADMYSFSNGTAATAAQNVSWSSHSDDHSSQGNSARRSSPPVSPSPSPNLSTSSSSTRTFPTTSTSPKPLNSGFQVTSRVQKLKNRSNSSEEIVKLSSGSHLGLGMMKNHACNPSNAEGNRRTSNISDKSFDEESLIDAYGVPSPVLATKASVGTTGLLEGVVVGGGQRMDVERSELTVLGTGGTRGTAVVTILCSVTPCLALFAIIRLYMSIGWDKFSGRRILFYLSPLHLDTHIYITLRQQLWQKLEKGEKGIGDGTCSYGLADGDDLMMEKWNGTIIGPGHSVHENRIYSLSIVCGASYPDQPPVITFLTRINLPCVHPTSGKVDPSKLNVLASWKHNYTLETVLVELRRDMASPTNRKLPQPAEGATF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNY7</accession>
    <name>A0A2X0MNY7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Kynurenine 3-monooxygenase</fullName>
            <ecNumber evidence="9">1.14.13.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Biosynthesis of nicotinic acid protein 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Kynurenine 3-hydroxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C021g09258</name>
        <name evidence="9" type="synonym">BNA4</name>
        <name evidence="12" type="ORF">BQ5605_C021G09258</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>L-kynurenine + NADPH + O2 + H(+) = 3-hydroxy-L-kynurenine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:20545"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the aromatic-ring hydroxylase family. KMO subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.9" evidence="9"/>
    <dbReference type="EMBL" id="FQNC01000083">
        <property type="protein sequence ID" value="SGZ20283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MNY7"/>
    <dbReference type="STRING" id="796604.A0A2X0MNY7"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00328"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004502">
        <property type="term" value="F:kynurenine 3-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070189">
        <property type="term" value="P:kynurenine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:L-tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01971">
        <property type="entry name" value="Kynurenine_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027545">
        <property type="entry name" value="Kynurenine_monooxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46028">
        <property type="entry name" value="KYNURENINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46028:SF2">
        <property type="entry name" value="KYNURENINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0274">FAD</keyword>
    <keyword evidence="2 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0521">NADP</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 9" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="11">
        <location>
            <begin position="35"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="11">
        <location>
            <begin position="399"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGZ20283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="603" mass="67413" checksum="F6CF698F5A0C9202" modified="2018-09-12" version="1">MERLATSSSSSSAKSSLAADREPDHRSSSESVRPKVLIAGAGLVGSLCASMLAQRGYDVLLVESRSDPRDAKTPASGVRARSINLALSPRGIEALRSVDENLADRVIQQGLEMRGRLLHKRSEANQSRVKKEAQDYGLYSEGEVIRSISRTLLGIYLLDHIDSLQHRNDLKGTVEVRFETKLLELDLRAEQGVKVKLSSKHKGEQELKVDWVVGGDGAYSRVRREMMRGAKTRYAHELTTPRPSWDSSGSCGHVSAPTLTTPPSWVHRFDFKQTYARHAYLELSILPSGKDNKWTMENNYLHIWPRGEFMMIALPNQDGSFTLTLFAPHSTFESLDKKLDEYNSSSVSARTGPNPVVEKFKAEFPDALELMGEDELMKAWTENPKDGLVTVECSPYHYKDKALLIGDAAHAMVPFYGQGMNCAFEDVRVLSTLIDHYQAAPFPSTKISSLPYSSSHPDFPSSNPAFTSLENALSAYTVVRTPSIGAIQTLAHRNYTEMAASVLSPIYLLRLYIDSFLSKLFRSVPLSSKTTYREGSVWESLYRMTTFRYEISYEEVLKRRAWQQRVLSWSVAGSVVSLLGVGLELARRSGALKSLGRLRWERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MP01</accession>
    <name>A0A2X0MP01_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C022g09488 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C022g09488</name>
        <name evidence="10" type="ORF">BQ5605_C022G09488</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Su(H) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MP01"/>
    <dbReference type="STRING" id="796604.A0A2X0MP01"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1450">
        <property type="entry name" value="LAG1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015350">
        <property type="entry name" value="Beta-trefoil_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036358">
        <property type="entry name" value="BTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040159">
        <property type="entry name" value="CLS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015351">
        <property type="entry name" value="RBP-J/Cbf11/Cbf12_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037095">
        <property type="entry name" value="RBP-J/Cbf11_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10665">
        <property type="entry name" value="RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09270">
        <property type="entry name" value="BTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09271">
        <property type="entry name" value="LAG1-DNAbind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01268">
        <property type="entry name" value="BTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01267">
        <property type="entry name" value="LAG1_DNAbind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110217">
        <property type="entry name" value="DNA-binding protein LAG-1 (CSL)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RBP-J/Cbf11/Cbf12 DNA binding" evidence="8">
        <location>
            <begin position="414"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-trefoil DNA-binding" evidence="9">
        <location>
            <begin position="570"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="161"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="228"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="331"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="710"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="710"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGZ22443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1021" mass="109005" checksum="E6B905F237F84368" modified="2018-09-12" version="1">MVSPATASGANSGRHPSTSTSSSPSMAAAYGFDPAPAPPLGILMHCVSGTSAAHASPLPPSPSSPYSAFLKPGHMSHSSMPAPLSFSPLASAFGGSEGIAPLAGTRPHLSLPPPQLLPEPAAFSTSHLIACAPNCLGHVSYPAPDSSVAASRDTAFLAPTLNPKPARDTMAHQPASSSLSSSMPPIHASRSGFDSPTLPVHQAWKTFDTALGAIRGAAGRNIDFSSAAYPKSTEHSRRNSASSTTGGAQGSPRCAQAASTTTQTSLPPIDPYKYKTSPVLGAFPMSTDSLAYPTERSYPLNPCSSSELNGYQPHPIPNFATDVRQSEVYSASSAQRTHSDIPHSLSQGFDAALPGHAPASPTLCQKRKRTSLLGEDVARHHRTREYPEVLLLESMRCSSSTVALTPPSRFPLTTITCLHASVGQKSYGNEKRFLNPPPMVRVTGPLHRLSGYPRLVVEVVSDNGIYCSREHSAIESEDGTTADPDARYYLRSLHIGKAGKAKTFRLELSLHPCDRPAPPKPLSQNGSVRKAEPMETMETLNEALASFSSAEMQIISKPSKKTVRARNTGSCLFTESTVALFNRINAQTVRTTFAVTEEGRLSSRAYQWTAFKIHVTKRAEGGKDADQDVGEAFLRNQADGGPEAVTYGSEIVLTDLMTGVTSEPMIVRKVEKGHVFLGARGPVAQLQKLALARVNDCGYSIYLSPSSDGINKDGLSQHSESYTYGTEHDPDGYPSDDDSAGAKKFLSYQTPVGSLPADDQDNLGYHIVTDFMTWTVVGIDSFSYSYFDTSPEANSPLRLSSLRPITPFPLVQSRPAYDPHTHTCSFAVSDFFNNEVDRSPMELWLGPLGPLATKIIQAGEFAAQPPHLEPGFPNIATGTKAERTKIPSNPLITRQIKSSLISFELPSIEAILAISGLPLAGSRESPATAGTSGTSLLVPMSTQAVHRNVQALYEQLRARSVSEAAEVSNASQTASLSRSTISLPFLFIRKDGIGYQSERSIVLEPNPYAASRADAWSISFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MP06</accession>
    <name>A0A2X0MP06_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C014g07679 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C014g07679</name>
        <name evidence="2" type="ORF">BQ5605_C014G07679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY19548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MP06"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY19548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="445" mass="50327" checksum="3C5D00C323D73A03" modified="2018-09-12" version="1">MVAILPAELLNAILPASLPAATRAGVRPRNAQLCTLAQLDRTWQRFAQAQLEECLGLRGEHFRKLELEHPDRSPSPTAERRRVDSSLGRHAAERARDAGERGRGSPFRSSSSACHMDTDRDDGQAQERGRSLLRRTTSYHKRIPIVLPGGARERASKVKTLVIDKCLDQQRYSVVKRSLAAFDQVEKVYLAGTGEWYALTSLNELPKLTSLHLARVYHALPPSQPFSSLTTLSISFGLPKHVDWALLRARLLPALKTFILHPVDWDFIQEQGATFYPAFEEIAPQLEAVLFAGQDHHLDEPVDWARMMRRLNKVKVLELRLTSGEALKSVEGLWNTEDEGEQVQGELRLGSKMITNGRLRELLFPKEEAAVEQDEVMVPRTRLRGLQKLCLPEVSGGEVWRRTKTSIDFDREDREAAKKWCALYGVELSWTGEEDECALVEEWKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MP85</accession>
    <name>A0A2X0MP85_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C021g09358 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C021g09358</name>
        <name evidence="4" type="ORF">BQ5605_C021G09358</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000083">
        <property type="protein sequence ID" value="SGZ21353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MP85"/>
    <dbReference type="STRING" id="796604.A0A2X0MP85"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044695">
        <property type="term" value="C:Dsc E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038967">
        <property type="entry name" value="Dsc4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013715">
        <property type="entry name" value="DUF1746"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39405">
        <property type="entry name" value="DSC E3 UBIQUITIN LIGASE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39405:SF1">
        <property type="entry name" value="DSC E3 UBIQUITIN LIGASE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08508">
        <property type="entry name" value="DUF1746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="374"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="419"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1746" evidence="3">
        <location>
            <begin position="371"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ21353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="621" mass="68879" checksum="8CC0C0B39FA1E6ED" modified="2018-09-12" version="1">MARVDVLEDLIPSKVRLEALFHSRPFLFGIIVESATGHGLGLRSPGIEFGAMEFEQGLAFVHAASFLGKVFVARLGGEVVHASELPFVIVIRRIGGTNLIIGFVLDFEVGLVYPTQPRFQGKGAILYPPQHAPILHDLHRFQIDNVVVFLWDRSTGADVGVVERRNGGTGRMRVGVVGRSGSGEGGVTVFDVEPCLAHATNDVLVRLFVQVRFDLFPITERMSRDVDGWVPLCVRLSLVYTAALLRLYRHGPGAIEIQRRRGVQKWSAYEPIHRWLGPSRASCLDQDPASVFELASAAWSVALARGCVFEFAFCSPIVASPPLPSSRATTSNSVSSSTHPNIRLGLSSPSPSSPSFSASSASTSRLELLASLDAIIWILFVHSYLLSPSHLLTFLLRLFSHVQFSSSRKIHPARSLRHLLSVWFFVNASSVIVHAWQGSRGTKGTKRWSSTGLIVDFVGQAITPSKSHLVLLDLLIALSQFVLIVLVFADPNSASAVERTEENEEIGRDYTALLGEEWAENVQADGERLDEEEQGQDLTSSTIRRRRKRRRKRRTHHSSDSSKYSSLPTTLPHSRPTPRTFDSPMFEIKLQNLVEELRRSNKVDREEEEEDDLVDLEEGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPF0</accession>
    <name>A0A2X0MPF0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C017g08411 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C017g08411</name>
        <name evidence="2" type="ORF">BQ5605_C017G08411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY19968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MPF0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY19968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="65" mass="7152" checksum="A5D27DF692978BCD" modified="2018-09-12" version="1">MSAEHTTLVKGDKVLEKVGDQIVAEKDYVRVLSGYKATAHKQNLPEETRKVHSASLSDMGRSHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPN9</accession>
    <name>A0A2X0MPN9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C001g00092 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C001g00092</name>
        <name evidence="3" type="ORF">BQ5605_C001G00092</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY43959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MPN9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY43959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="142" mass="15698" checksum="08CEEE5972002864" modified="2018-09-12" version="1">MSQLSEQLLTADLAPFSSSRFAEQQPQISANAAAAPVLTPRSPSPSTDVTPRPSVRQSYLRSAFDNTVAWATSSARHLWYMFVHDHHVLFDIFLALGGFATLTVYYLRVKSYLRFGAGLGFFLSAMGVTTFIPRPSLRPTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MRK8</accession>
    <name>A0A2X0MRK8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BQ5605_C051g12526 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C051g12526</name>
        <name evidence="12" type="ORF">BQ5605_C051G12526</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000096">
        <property type="protein sequence ID" value="SGZ29524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MRK8"/>
    <dbReference type="STRING" id="796604.A0A2X0MRK8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11042">
        <property type="entry name" value="CYP51-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000033">
        <property type="entry name" value="14-alpha sterol demethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="7 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="584"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGZ29524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="637" mass="69485" checksum="7C4622DAED47AB2A" modified="2018-09-12" version="1">MRSKIGDFHEFYLRASGWAFMGPVPLRAPVAANRSQSPDLVRSTTASICLARPLLPSIHSLALALALALPAVRSRVPSSMPTALVSDVLSVAGKGATAFVGAALLVVALNVVQQLVLPRDPTKPPVVFHFVPVIGCAITYGMDPIGFLNRCRDQSVTCSNPLPLLGRSQYGPVFTFPLLGRKVTAALGPLGSNFVLNGKLAHVNAEQAYTHLTTPVFGTEVVYDVPNAVLMEQKKFVKFGLTTENFRQYVGLIRTEVLGYMNKEVFKASKVSMVRPIDAFSTSADAFTTSSEITILTASATLQGKEVRQSLDKSFAQLYHDLDGGFTPLNFVFPNLPLPSYRRRDVAQRKMREFYVAILEKRRNSAEAPDMDMLTALQNQEYKSGAPLTDKQIAHIMIALLMAGQHTSAATGAWAILRLGQHPGILKALWDEQVENHGDGKGGLKPLEYDTLLTPLLSAVIKEVLRLHPPIHSIMRKVIADCPVPSTLATPAGEPTASSSFKKVNEGREYVIPQGHFVLAAPGVSQVDESIWGTDANEFRPARWLEDAKVPGEEEEGEEDYGFGKISKGGKSAYLPFGAGRHRCIGEQFANVQLGTIIATLVREYSWTLDADFPTNDYTTMIVMPSKPRNVIFTPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MUC1</accession>
    <name>A0A2X0MUC1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C067g12834 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">BQ5605_C101g13144 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C067g12834</name>
        <name evidence="2" type="synonym">BQ5605_C101g13144</name>
        <name evidence="3" type="ORF">BQ5605_C067G12834</name>
        <name evidence="2" type="ORF">BQ5605_C101G13144</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000074">
        <property type="protein sequence ID" value="SGZ10945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000135">
        <property type="protein sequence ID" value="SGZ35336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MUC1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ10945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ35336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="463" mass="51366" checksum="FB6153A5FFF0A099" modified="2018-09-12" version="1">MEARPRYRHQSSPRDLHEFDALQEWERLLVRCHPVEVASTPSTPPAGHMSASMLLRDSGDATCASSLISGRISPFRDQRHGGTGPWKRRRLNSASVVIGIVFGLVVSCLLDRVTKDTSLSFPSIKEGVIFPWKSASKLPKIGKTPRLWIRTEANEEGIGSALQRIKGGIILAAFFDATFIVGETLSQHGYYHDEVLNPHAFGPDGVDAWQVPSGRVCRISDYLPRYRRDMVIRGACSRLGKGYELGLRVKEQLDERGCTIILEDIVHEVVEDLNACYRNFVRQRIGGIEGRRLDRPSVEGSAVSPDRTALSCGVHIRWGDAEMFEGTMEKPRGSMQLVHINDIISKLRARFVKLDIRVVMENVNATVLGLLDFDDYTVIDSGDSFADLFALADNDVTLLGGSSYSALSHIIAPSKGLSIVEGMDLPNKYLDSTYRAVVLNSGRAVDYVQKIVELFPEVETKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MUC4</accession>
    <name>A0A2X0MUC4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C007g04509 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C007g04509</name>
        <name evidence="2" type="ORF">BQ5605_C007G04509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY60971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MUC4"/>
    <dbReference type="STRING" id="796604.A0A2X0MUC4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021487">
        <property type="entry name" value="DUF3140"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40630:SF1">
        <property type="entry name" value="DNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40630">
        <property type="entry name" value="POSSIBLE DNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11338">
        <property type="entry name" value="DUF3140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY60971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="131" mass="14742" checksum="AA79BF449E0B0E44" modified="2018-09-12" version="1">MGKSDEQVIEEFQKYVNMTPEELEEWLETDESKGSGWTGDDGAGGESVGHDSGRKIVKILRSDPQNPSEDELAHMRKTLADCLSIHAQVCAYCARHLAQEGKMKESKDENELTETKAYRSLKNWGHDMLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MUL0</accession>
    <name>A0A2X0MUL0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C002g01807 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C002g01807</name>
        <name evidence="7" type="ORF">BQ5605_C002G01807</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY35836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MUL0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="56"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY35836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="362" mass="39540" checksum="82E41937A9B30FBA" modified="2018-09-12" version="1">MSSQTEIKLPMFIEHQDPMSSKSMMDTGLSESKLSMQAPPQHVVSKTEPTKIWPGYIIMIWICLSSGVIIQNAWILRTLKFNYPIFLTTWHLVFATIGTRLLLHFTHLLDGIDALQMSWDRWFRNIVPIGVLFSASLIFSNLAYLTLSVSFIQMLKAFTSVAVLGLSVVAGLEKMNPRTFMIVIAISSGVALASFGEIDFVLSGFICQTLGIMFEAARLVSIQKLLTGLKMGPLQSLYFFAPVCAGLNALLIPFFEGWAPFENALSQVGAPILLGNAMTAFSLNIAVVFLIGCASSLVLTLSGVVKDILLVGGSVLLMGSTVTFTQMLGYSIALVGLFVFKTKQEVLDHTILRVRGLLSGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MVE5</accession>
    <name>A0A2X0MVE5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g02139 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g02139</name>
        <name evidence="2" type="ORF">BQ5605_C003G02139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MVE5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="524"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY39086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="555" mass="63149" checksum="CB393811F5FDD920" modified="2018-09-12" version="1">MPVQTPTPVKVPTCQGHTSSVSIEDHHSTKTTPELPTRRSRAAHWRSQLTQKDRVDPIDLRKKLRLLLVDKFGEDFHERFKTRNQYDTVFVIAPTGSGKSLIFQAMYLVYGRRAVTIVVSPLTALSQHQPYMLPACNPGCWMAPGLGQLANEIDLLLGSYFEGHPDYKPRGLRSDARLRTNIPGTRHMVTYTARQIQQRTFDEHARGEASSPSPRPPMAPLIHADFDEAANPSRMDWDDERHSEYGGGHERDFSPAPYFPDRTAHMPIAPDYIATAERLSLADLRQVESFEPATRGQSKQETYKQFVFNEARLRSLERPALLRQYIAARVLKEYRTRIQDFDDILARIFTVPVDIAAEYEESRLFREILSPLYQECQRPLPEDEIRTDEDQEGSDRLLRWIQKVYRPFLGKRVPDEYWDQLESEHRTRQAALRPFATTVLVHVPEPPKPPTDADLEPERKKIWDSWIVECAHRWLALSSKQRDAYRWMRKKGSGGEGAASTSGAREEDAISEHSSATGQHSEHGAAAGSEAESNLSALSELTSLSELERGLDTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MVP5</accession>
    <name>A0A2X0MVP5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C004g02712 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C004g02712</name>
        <name evidence="3" type="ORF">BQ5605_C004G02712</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY66849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MVP5"/>
    <dbReference type="STRING" id="796604.A0A2X0MVP5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="77"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY66849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="462" mass="52233" checksum="2EA2A4C825F40E3A" modified="2018-09-12" version="1">MPYVTLPGSIELYWEAYGPRRDKLDPSEPGTKWAEPESPSTSTSTSYRSIELKPDGSLDLRTDVPTLIVLAPIWLDLSYCQSLFDRFAPQYQIVALENRSHGRSTRSPVMPSFDFFVSAADVAFAMEALSIPPSHVFCSGALAFQVGLKLCLLFPNQVLSLALVGAGQLFAPPDHVEVFEELDQCWFFPVDEGDYYETLEVISEIFLSDYNHREDSASIELKDRIVNTFIRRYNPYRLPSALEVTRPNHRHPCLGTEDLSGVKQPVMLLHGGLDKCYSPDTVRGEVPAWLQSSKEVDWHVIEGAPHLLALTHPELVNDYWAKFLARHSVLNSTWIPLDRDYALQVLAGLARHTNGEIAPEDILQRSGDDPHDFSLVTPLEVDLTRAQIVKFSQYGAEVCRLQFPGRYTADPWDVSVRTKKGRSFSQEEWTISRRHVLDDRFQAPRKPMNPQGISVSVLADRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MYP8</accession>
    <name>A0A2X0MYP8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Inorganic pyrophosphatase</fullName>
            <ecNumber evidence="4">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Pyrophosphate phospho-hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C001g00734</name>
        <name evidence="12" type="ORF">BQ5605_C001G00734</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>diphosphate + H2O = 2 phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="4"/>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY49066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MYP8"/>
    <dbReference type="STRING" id="796604.A0A2X0MYP8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.80.10:FF:000004">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="INORGANIC PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00387">
        <property type="entry name" value="PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY49066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="287" mass="32275" checksum="B53006C274C41642" modified="2018-09-12" version="1">MSEYNIRQIGSANTLEYRVFTEKDGKVISPFHDIPLFANDTKTVFNMIVEIPRWTNAKLEISKEETFNPIRQDTKKDRLRFVRNCFPHHGYMLNYGALPQTWEDPNQMHSETKANGDDDPLDVCEIGEAIGYTGQVKQVKVLGIMALLDEGETDWKVIAIDVNDPLAGKLNDIEDVERHLPGLIRATNEWFRIYKIPDGKPENQFAFSGEAKNKRYAIEIILECHEAWKRLVSGQTKSDIAVTNLTQDGTPGKVSTSDAAYSSLPADSRAAPAPIDPSINKTFFISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MYX4</accession>
    <name>A0A2X0MYX4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">18S rRNA aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="6">2.5.1.157</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C001g00834</name>
        <name evidence="6" type="synonym">TSR3</name>
        <name evidence="10" type="ORF">BQ5605_C001G00834</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1191 (Psi1191) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1191) in yeast 18S rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63300"/>
            <dbReference type="Rhea" id="RHEA-COMP:13852"/>
            <dbReference type="Rhea" id="RHEA-COMP:16309"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an N(1)-methylpseudouridine in rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine in rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63296"/>
            <dbReference type="Rhea" id="RHEA-COMP:11634"/>
            <dbReference type="Rhea" id="RHEA-COMP:16310"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
            <dbReference type="EC" id="2.5.1.157"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TDD superfamily. TSR3 family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.157" evidence="6"/>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY49906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MYX4"/>
    <dbReference type="STRING" id="796604.A0A2X0MYX4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106388">
        <property type="term" value="F:rRNA small subunit aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01116">
        <property type="entry name" value="TSR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022968">
        <property type="entry name" value="Tsr3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007177">
        <property type="entry name" value="Tsr3_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002621">
        <property type="entry name" value="PRK02287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426:SF0">
        <property type="entry name" value="18S RRNA AMINOCARBOXYPROPYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN TSR3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04034">
        <property type="entry name" value="Ribo_biogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNase L inhibitor RLI-like possible metal-binding" evidence="9">
        <location>
            <begin position="78"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="16S/18S rRNA aminocarboxypropyltransferase Tsr3 C-terminal" evidence="8">
        <location>
            <begin position="132"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="261"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY49906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="331" mass="36539" checksum="E016E09A6339C7AC" modified="2018-09-12" version="1">MAPPKSRYRGSTSKGSTTHRHSTRGGGSSSTGSRTDRNVYGGVSGIEVPASAVDQEGNSEEDEGNDVDGLTREGKRLPVAMWDFDHCDPRKCSGKKLARLGLMKELRVGQKFQGVVMRLFSLVNVVPTSSSISPKGTQVVSPSDRDIVASSGVAVVECSWARLEEIPFHKIKSPHERLLPYMIAANPVNYGKPYKLTCLEAVAAALYICSFPTQAEELLSKFSWGHSFWEINGPIISRYQTCSTPESVLEMQEVIIEEMKKEEEERRREKERVEEEGDLLVLNPNHMRGAWRPHHSDEEEGSGEEDDGGGSEDGEDKVDTVTTAVGRTRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N673</accession>
    <name>A0A2X0N673_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C008g05137 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C008g05137</name>
        <name evidence="3" type="ORF">BQ5605_C008G05137</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0N673"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051114">
        <property type="entry name" value="Mito_RNA_Proc_CCM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47934:SF6">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR CCM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47934">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN PET309, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="1348"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="1383"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="1536"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="205"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="371"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1605"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="205"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="414"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="434"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY79460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1689" mass="182336" checksum="1C8049CEB29E370F" modified="2018-09-12" version="1">MPSAVGSSATLSEGGRIAPCGFASNQAHVPSLPVRPSTFASRVASNPISRVSNHDPGFTGHWDTQSASPSTPKPSIPRPRRPTLRVWSRIKTTGLCALPFSPHFKTQHNQTRCKDTKTVLLSHLAQSFRPQHHFNTLRNAFPSSASAHGGSTTGFFDPANVFQHAANNTLGAATGQAAGAGPGSSAGGAGGAKWHAGRNAYNWGSSNSGRMMSQATSQDPSTRLDEEAEDSSITRGRRNVLLTPHRAGRAAPAPFKSATRERSSSIPSSTERPAPPTELLRVSEMGLQAPRLSSTEMQSRYRFAFAQGTKTVEMVAMEREADEMDLGPQASSVRVSRRRASISSVTTPSFIRIPRPLLLAGSSSSAAAPLLSARGVHTTTKSSPSSRRTPFPSTSPPLATVARVRRNSTSAIEPSSPSPLDSADAALQVPPPRQSSSRPPASSPNDPASMMLRQRSPAFTEKMEAPTIETIRNLSYRSPEAANDAVRHYLAVESAYSVEGHNAAMEALLRTRLPNTPITTIVHLYNQLFEHEALRPTRRSYELVLKTFCTRDQEVLNNISFLTKRIERKKGATLARGPYHRASSSEELMMNPAEQRTLETLQKEDYLSPALEIYKTLGPLGDKLEDGVMSGLIAGAARRGRIDLALTLFGRVEKSPFQKALPGTYIALIQMFGREKDKESLMAVFEGYLQARAAGQLRPTNSAIKRPFHQQVPVKHAYSTAPEFTFRANSGFFVGGDDAVWRNTIAALFEVGDSAEAVALLERMLLAQNSSEPLPAGYPTKFAPAMLATIVAGFASLGDESSARKWFDQASAVASSGVPVELHGIAFHAALRADLPALLRHIYAASLDRAGPNFPLSISDFVTFIDTQIASLYSSTTSAEDARAAIDAIVSARPKFEQAARKGWTLGNPQREVALSTGLLSRIVSAFAHCGDWTNAANTFVEMGRTILRAQVSKDSVRSPEKWILVGRDSAMTALGFVPQDAKEWTRNADAPRLPIAEVTKVVAMLNRFSLQAGTNETTPSAVQVLVVECFLSAKAENKGDVEALKLSGDQWYAIIDAFASVQSQIRRGLEPAFEFPGFEPIIDDFAASQVKIPSTFANNFPALVESLLAGGMPSDRARAVLAVLDLNLAQSLEAKEAPAPVEAPAAAAQVDSPSVAQSARTYAAEPAPVVIPTPPATPPPHVLKQLSAPLPTVNAIDINLSNQLDTLIYGHSYDDAFKTALQAADQGRYAHPEALGRLLEALGRAGKTEAARQTYILAYASLPALAAHPTDQSMAWSALEDHMIITLAVAGDLEEVGQHRDRLIQAGSAPSADGYAAMILHMQETTNDAAVALTLFEESQRLGVKPNIYLFNTLISKLSRARRAKDALEYFELMKSYGLKPTAITYGAIINACCKTGDDASADYLFQEMIASPNFKPRVPPYNTMIQFYTSTKPDRARALHYYRALLNARVQPTGHTYKLLLDCYGSIAEPDFASMEDVFATLLQDPNVIVTGAHWASLIHSYGSVGNDLDKAVEIFDSIQGHASTLQSRSDLPDAVVYEALLNAFIANGRADLCENYLVEMKDRGVKMTAYVANTLIKGHAAQNNMSSARAVFDAMQDPPAGFAASGNHAVNRHPKQQQQQSSDPAASGPVYREPSTWETMIKVELEAGEAQRALGLMKRVEERAFPEAVVARIRKHLDDAGLVSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-11-27" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N727</accession>
    <name>A0A2X0N727_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein ROT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C009g05478</name>
        <name evidence="3" type="ORF">BQ5605_C009G05478</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Required for normal levels of the cell wall 1,6-beta-glucan. Involved in a protein folding machinery chaperoning proteins acting in various physiological processes including cell wall synthesis and lysis of autophagic bodies.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY81172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N727"/>
    <dbReference type="STRING" id="796604.A0A2X0N727"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006458">
        <property type="term" value="P:'de novo' protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019623">
        <property type="entry name" value="Rot1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28090">
        <property type="entry name" value="PROTEIN ROT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28090:SF2">
        <property type="entry name" value="PROTEIN ROT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10681">
        <property type="entry name" value="Rot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017290">
        <property type="entry name" value="ROT1_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016002166" description="Protein ROT1" evidence="2">
        <location>
            <begin position="44"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR017290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY81172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="218" mass="23982" checksum="97C8B193BEF024BC" modified="2018-09-12" version="1">MGRPTPRPSSSSSSSSSLPTLAAWTTLTVSTLLLLLTATPCEAAQDFTSNLTNWEGTWSTGTGAVVTGPGFADPMNNNKPFKYPTNTGISYSFTNDGYFEESQYRFLGNGSKPTCSKAVAIWQHGRYYFHDNGSVTMDPSIFSADGRVLVQDPCAAQTEILTYYNQPELFNGWTITIDNHHQAYMLQLIRFDGSYFPRLFLTVRPPTMLPTADLTAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N744</accession>
    <name>A0A2X0N744_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C022g09563 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C022g09563</name>
        <name evidence="3" type="ORF">BQ5605_C022G09563</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N744"/>
    <dbReference type="STRING" id="796604.A0A2X0N744"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000003">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="197"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ22940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="416" mass="46341" checksum="79188E659C2591DA" modified="2018-09-12" version="1">MDGQSPPLIRARPSAEQGTTRGVRGRGTSICTTSKTHIQDLECQIFCTTFESQFGVRRLCFPHARAHGRYSQRTFPFGLSGLHCVVDVSLPASAAAFTTCRDRCVPHSQDYLPADDRDPAHSYLFSTSEEGFPSVFPVGPPDSAEYLDDLRSALPSEYHHLLQAVSKAQADTPASSTASTSFRPSLPSVRKGASGTLMNSIFRDLLDVTALVYLDDILIFSDSPSDHVVHVQEVLRRLIDNRLYCNPNKCEFHQSSTEYLGFLISPDGVSMSPSKVDSITSWPAPTTLKELQQFLGFPNFYRRFIQGYSRIISPLTRLLKKGAVFDFDSLALAAFNRLKSLFASDIVLFSRFSDSSCCVLLLQWTPAEQNYEIHDKELLAIVACMKLCDIISKEFTTQSRSSPTTTRFNTSRRPKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N8H6</accession>
    <name>A0A2X0N8H6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C025g10008 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C025g10008</name>
        <name evidence="10" type="ORF">BQ5605_C025G10008</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000087">
        <property type="protein sequence ID" value="SGZ26956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N8H6"/>
    <dbReference type="STRING" id="796604.A0A2X0N8H6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000743">
        <property type="term" value="P:nuclear migration involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF6">
        <property type="entry name" value="DYNACTIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0243">Dynein</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="9">
        <location>
            <begin position="207"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="66"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="286"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="683"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="877"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1067"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1122"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="721"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="795"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="964"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="315"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="361"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="402"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="450"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="877"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1067"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1098"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1148"/>
            <end position="1160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGZ26956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1187" mass="127549" checksum="FB29B01B6EE3BB6C" modified="2018-09-12" version="1">MALRPPTTPRASTLLSHNSVAAAGSTPSSLPTPSRRRVSSNVASSSRSNLGGAADELDSLQQALRSHDPSQYDPPHLLGNSYASIDSPTPNKLSHTVTHRKALRRPSILNLKSNLAVSGGGSGASRPTTPSGRTSGMGVSTPRHHAMGGSMTRSKTPTSIATRPLSRSTMRNSLDSSIAGFKGLQVGDQVKFEVAGNAMEGVIRFLGAVDGKEGQWGGVELDAEWSGLGKNDGSVKGVQYFACNPLCGLFLPLQKITKKPPAPPAITAGSRASKYVGLKASELASNKRQMEQNRASMGPPASPTKGQPRRSLALPSPIKLGSISSSSASASSTPRAIRSGRPSYGGGPFGATPRKSLGGISASSTTPRANLSSSAAGMKRPPSSLRSNSIPDVPALPHSYALNRSITPSSSRDGRATPSTPSLVSSRMQRRESEISTTSSSTGLGGGLGHSTSRPTTPSVRSFSRQSFTSSSVSRNSLRSTTREEDDIADYKQQVVEAREREASVRELLEGSEKVGREMEALVGELRDRLKERDVQVEEMERKVKEREMNRLAEVEDDDAGSKKELQRVLKEIEEMREEGKVKQEQWDKLQREWMTKSAAKEGEIASLRERLDIATQGVDEEKAELQRQLEQLRSAGQSLCLTYEERIAEIEIARLESVDLAETLAAHLEALQLGGRGGVIEKGMTTNDDGEEVHRSGSPDSPTRRLGASTNASVADIINAESAQADLDHLRTKVGSLEEQLEEARMHLEAEVNDSRRRRTKHQEAEAVLKKDLKGLRDALDRSAKHETRLTSRIAELEVALQESQATLEDERSELEGLRSDVVGGASAGIADELKRANKLVGKLQEELDEVKQSKAQQVERVSELQTQLDEALLSISQRSSIPTQAPTQDTGSASSQLSPTSVSMNRRESSLASSGGRRSVGSQADEIADAHEQIVGLKIIIKSLEDDNSVLSERNIALGNEVQDLKDAQQALETTVENLMGQMTNADSSSVAVKVISSPTMDAKGTRAVREVEELKLKLREVEKKAEREIKVLHQEVNELESLVESKIYREDELETELEKYKALAAKAPSSSSTSGGASSSTATTKGNGLTRSSKEEDDDEDNGECEMCGDLHDLESCPVFAGSSSPSKVGRPRASVSGGQRHAKSTSLASVSSEGVKTSTEAYCDDCEEYGHALEDCPLANDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N9C9</accession>
    <name>A0A2X0N9C9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C027g10320 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C027g10320</name>
        <name evidence="9" type="ORF">BQ5605_C027G10320</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N9C9"/>
    <dbReference type="STRING" id="796604.A0A2X0N9C9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF34">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR OF PROTEASES PRTT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="133"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="731"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="845"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="750"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="852"/>
            <end position="872"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGZ28355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="872" mass="94430" checksum="9DA1393490393B59" modified="2018-09-12" version="1">MGSARLAPPANALAPVPKPLAASFGTDLEQFAFSASSAPGTSRSQFIRRDREIDPASPLLIANHTVPCRRCELYGLECKFPPSAGVVATTITSSSGVLDGSAPVAIKKFDEIAARLRNIEAALNITSTYPAEGYSPMNATDSRSPSRRSASPASSDGLATADELDKEKANPIHEINDSIDMIVGKVQARAGDGGIAESGLDDYGAPDVVNRGTLTQHECQELFDFFFCSIHPWVMMLSLDEDRDAMGVRSRSSLLFHTILCLATSFSSPFPSALHATLVCYVNAILAPQILNPQPHELTTDFLRAMDLLNLYKPTQFSTRRAEGKDVAESMRASKVNGLASWMLQGILARSAERLDLASSLSRFSRAYSASASGIAIPKRLLRDLRLYYWLLSNDVHGNVQSGRRCNMEGAAALTTTRLFSSLQLQPYDVRLAASVEMFEVARPILRSFSYERTRRIAQVDLDRYNSGMAAWEEFWLPMLQQQLAVDPLAMSVMCPFAWFITLQFNAAAYVSWKEKRFSSTDSTDGAFPDLKQEPGLMGGGGGGPGGPKAKRARIEPKGLTQCEHEGLERCVRAAEGLLFTLCEESRVVGAWRTVQWGGAERADGWSKLTLDQSIVEMSKWGMDAITCVAYIFPAVFLCKLVNEGILTPNLELSRNPSVQIPWRYSQKLPRLLELGASFLDSIALNPHHPARAQAHVLRTLLELGIKGVPLSPQSRPTENGHLAVPESMGHYNLGAQSMPGADGRMAGAYTTSPQQQGPRWPTSLDSSSADRSQRRYPPAAMPASGNQVLETYAALGPGRSAGSLANSPGGKQPGSINIDMALTNVLDGFDPMWTESGGWGWGNDLDGIGAGSSSRPSSNTGATPQPNMYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NBI7</accession>
    <name>A0A2X0NBI7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="24">BQ5605_C044g12126 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">BQ5605_C044g12126</name>
        <name evidence="24" type="ORF">BQ5605_C044G12126</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000114">
        <property type="protein sequence ID" value="SGZ31285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NBI7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="23">
        <location>
            <begin position="325"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="SGZ31285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1224" mass="135203" checksum="459EDD2FD12D02C2" modified="2018-09-12" version="1">MISTYLFDQLYYFTNEQRTQRALPAINSLADRMRVQLRSTNVPSTQLALLASSSSRPTRPKCLACRSPSHRVAECPVRAKHPPPGPCRSCKQNHWSFDCKKALENGKKADTANSTANSQHHVGCIATGLLARRRQLRTNSFVVDLGATSHMVSDKSLFTTYRHIAPTKIGGIAGGINAIGTGNIAFVAASGHPITLTGVLHTPGLFVNLLSVSRLCDTDDVRVAFTKHGIDIDKNGHNIAEGTRLDEGLYLLDADHSKCQHLALLSRSQSSVPLLTLHRCLGHLAPSSIQKMVAAGLLEGLGAGYSDEEVEKFVCNACLSAKGHRLPFPDSDSHSSERLGLVHSDVLSLPERSLTGKQYLVTFLDDYSRKLWAYAIGHKSEVFSVFKTWLAEVELETGATLKVLRTDNGGEYCSRAFTDFCKVRGTRRQYSIPRTPQQNGRAERVNCSIVEGILALLADAHLPKTFWEEAAAYFVYCKNLVQHSALDKATPNSVWQGGRTTASALHPFGCAAWLTVAPKLRSKLDPKAVRVLFTGYDLASKAFRFYDTTTKKVTLGRNATFLDTEFPGLCGDSAEPDDDTHFASAPFADPQTTVKSWTPLYSADPLDLIGSQPQAPLDPMDTQPPDFSTYREPASAEELPDELDLIGRHSRDESPDKIDFLTRHHRAFIATDDDTSDTEAIEPVKSITSDPQTWREAMSGDKREVWAKAAADEFNSMRDDFKVFTIDDHSTVPAGATIVSSKFVWKTKRNALGEITGHKARLVAQGNRQRDGIDFTETFAPVARFSSIRSLLALAATNGLHVHQADIDKAYLHGDLDHNIWMTAPRGFDLPGDKVLRLRRSIYGLKQAGRIWNRHIDALLRDLGYTATGTDHCVYSRLDDRQRPHYIALYVDDLLMISPDLAEIERVISGLEQRYGVKRLGPAEYILGIQIRRLDDGSIALSQERYIMDVLARFHFDTTTCGTTVPMTPGLSLTAIPGQATERIRSWYLQAIGSLLYISLGTRPDIAFAVSYLARFANNPGHRHWIAVKHIFRYLRATYRNELVYARGEARITGVVGYSDANWGACVDTSISTMGYVFYIAGSAVSWSSKRQSRVADSTTDAEYLALSHAGKEGIYLSQLLEELHVQPVAPAHIFTDNEAAAAVARDPVRVTGTRHIRLREHFVRDMVNWGDISLSHVGTSDMVADIFTKALGPKVFSTHCYALGLRTRHPRLGSASHSRGGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NDF1</accession>
    <name>A0A2X0NDF1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C022g09465 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C022g09465</name>
        <name evidence="2" type="ORF">BQ5605_C022G09465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NDF1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ22271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="284" mass="32264" checksum="CD1A68FE85922858" modified="2018-09-12" version="1">MDEFADLDISDYEDDSATLARRARIEAARLQARDYSAKLEEPEWYLTSETQSSSPSTIPLQEDHGSTSQLKDLHRRKIFAIQHHYLQRSYLTSLNLALILSNGNSYIRGDGSEDVEVLDLILRSFLKLWEKDPEGLVGAGAWKEQGPMIVEIARKWPNYRGVPTFSFTASKVLILLSTNPSPPVAVENPQETLSPILNALKLHLTQSRYLAQLERVLQFLDRPVLAKALTNPNGPEVTMEDKRKAFEGLILTEEERWTLEKVTGLRGEVQDEPQEDHLRDVRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NDI3</accession>
    <name>A0A2X0NDI3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C022g09495 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C022g09495</name>
        <name evidence="7" type="ORF">BQ5605_C022G09495</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NDI3"/>
    <dbReference type="STRING" id="796604.A0A2X0NDI3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000002">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF203">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="6">
        <location>
            <begin position="41"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="376"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="397"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGZ22494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="487" mass="53391" checksum="E40D99615628A6D3" modified="2018-09-12" version="1">MLRTDLADTCMHITGLQLPDLSVEQVLSQTIQPPEQARIHAAMDSLHMVGAIDRDEKLTSLGRVLLHIPVEVAIGKMCILGSFFRCLDPVLTLAAILTNRDPFMSPIAVKDQADLRKNTFTPKDFRSDPLTVLAAYNEWEHIISRQGTNRAYDFTRENFLSFPTLLLIQKIKQHLLQALDKAGVLELGTAGQAGGMNNRFRRRGRNVTLPPSLNVNADSMPLLSSLIAAATAPNFAIRTSEKTFRTSQDKVCAIHPSSVNSRKNEKVAAQELDVAINEIVSSDQLYAFGEKSKTGSLANPSGGGQMFLRQTTMLDPLGYMLFGAHKLAVTDRGLECDDWLPIVGNVAVLDDVERLKDVLDLSLLRVFEGLGVQISGSGGRGPAARRTLGAGGARDDDRDDDEDSEGEPEQDPYDSQKQELSTAEVADLDKLTRHVVKVLNRYVSSNRALSPPGTTADWGPSLWPRIDSPRLVWNARPLQPVRGLTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NEM1</accession>
    <name>A0A2X0NEM1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C024g09909 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C024g09909</name>
        <name evidence="1" type="ORF">BQ5605_C024G09909</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ26412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NEM1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ26412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="200" mass="22287" checksum="D7C660CF9E831FE5" modified="2018-09-12" version="1">MKIERCTVPECARGEQWYTIPLPSSPRAKKQKSCLIARARTSSFGWLNGPADLSAPSLPHPSIAHSWWRFLDVDSYIMVSFMSWSVPMCVLEWAAREPSPYPYPPRQGTTHDASRHLALDQECHDVSRRCSDPACLDALSHDAVVVGAGTRLGEAAHGHALFFLPPCVRNVFGPFRARMLPSLSFVCPLESKDRFFASTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NG94</accession>
    <name>A0A2X0NG94_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C055g12639 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">BQ5605_C105g13177 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C055g12639</name>
        <name evidence="1" type="synonym">BQ5605_C105g13177</name>
        <name evidence="2" type="ORF">BQ5605_C055G12639</name>
        <name evidence="1" type="ORF">BQ5605_C105G13177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000078">
        <property type="protein sequence ID" value="SGZ11458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000092">
        <property type="protein sequence ID" value="SGZ29172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NG94"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ11458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ29172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="58" mass="6721" checksum="A2CDEFA31C33D330" modified="2018-09-12" version="1">MVVTAWIGKKARSFSSSSSRYGKARSFYWIVFARLPTAQQPALETQPRRDIRRCRGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NLH2</accession>
    <name>A0A2X0NLH2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C011g06484 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C011g06484</name>
        <name evidence="2" type="ORF">BQ5605_C011G06484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NLH2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY12367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="277" mass="30080" checksum="569766D74927F4DF" modified="2018-09-12" version="1">MSLTGSAEAPSQQSDSHRTATIGMEPESRSTKTSDRGLHVPILRASNYVDWRQRLVGRLGSKDLRLCASTRMSPAAEARLDFAAMDAKIAKELKKEVRTQAEVIQFLDEANLRLVRGCYTSYNILDSLNTFYLGKMSAQIYALTTELYARASSRLAIACGSGMPPAQQSTLMLNSVFDSQHESFTSSLHRPLALPSEIVSEARSYQFKVSLASQINGLSAATSGRAIAQSPVPALVAQGESQKGPRRKRGHKKGNRDGQGNRRPPDSTCHACGAKGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NVM3</accession>
    <name>A0A2X0NVM3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01154 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01154</name>
        <name evidence="2" type="ORF">BQ5605_C002G01154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY30431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NVM3"/>
    <dbReference type="STRING" id="796604.A0A2X0NVM3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY30431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="230" mass="24319" checksum="631EC11A3F2BAA79" modified="2018-09-12" version="1">MDNNNNTNNASHAAIPPLRPDPPDPPGQAPATTTKSYSAAVGARSATKHGNATANASTAVAAHPLMHNIENCVIINTPPSTSVEQVLLALDKYYPGLTGAMPCVIKGQRGLRFPKAADLDTLVANGLTVGKTLCKVEKLYSSTRGGVVQCTLTGFFSDPEGLCLFDEQIAAYGTVLRRRIQYIGKTKHISGVYDFILALKDVDVLPPASLVEIEQRCAERVGGSGKPMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NWF0</accession>
    <name>A0A2X0NWF0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C012g06841 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C012g06841</name>
        <name evidence="2" type="ORF">BQ5605_C012G06841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NWF0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY16313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="185" mass="19229" checksum="116816B290C1AE3B" modified="2018-09-12" version="1">MVVVSSTTATQRLLVRSLTTSTRILNPVAGASPSSAPSPSSSSSTSPSIHERQSRQRQPQSILHVADAGGATMAATLRAIELTKARKESASPSSTTTQPARGARQPPAFIGEGGLGSLLSRRRRAQGVVYDQDAQEIGALASSAPSPTARQSNTGASPRFPRATTPLPSSNERRSERLQSSSGDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P1P1</accession>
    <name>A0A2X0P1P1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C002g01389 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C002g01389</name>
        <name evidence="4" type="ORF">BQ5605_C002G01389</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY32633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P1P1"/>
    <dbReference type="STRING" id="796604.A0A2X0P1P1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061685">
        <property type="term" value="F:diphthine methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052415">
        <property type="entry name" value="Diphthine_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042:SF1">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY32633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="72" mass="8128" checksum="99DB74AE801F357D" modified="2018-09-12" version="1">MHDGFKIIEFGEGMGEGKGECVLKTRFDGHESLAYGVDWARSFNRKGEEEEAGDVVASCSFYDHMLHVWEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P205</accession>
    <name>A0A2X0P205_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01598 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01598</name>
        <name evidence="2" type="ORF">BQ5605_C002G01598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY34210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P205"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY34210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="631" mass="71024" checksum="42041637B0C98D89" modified="2018-09-12" version="1">MTLQSYNSTCKRDHSLSRDAWTELFILLRIYTCHDADLSECPSTKWSERYDISPASELWRSGSAPKVTSPMAPNDSKTLRSVQRPGAARNVSRWARMPYPRQSSRATRWSTHKASGGSGSYPVVRQWVDGLHAPTFYANGDLKPDNIPLATFSNGTEVLAHSNANRKVNAHISWVISMTLPPGASSPWKPLYLPFCVPHAKAFENDEGVIVLVLDHPEWAGLVDTATTFQTPGGQEVRLDDERNYNHYRRVVEAMERHPTKLESLRRRGTGISIEQLRLYELDERGEVSITYTYLYVLLLEQTLLLREKLLYDRDPEFLHLFPATNHRLMHGPDVMKKMGPLRDYSACGTETMMSYSKGRTRSKSNPVESGMNSAEMRFMMIILRLKKDIPTMNELRDTSPRDHALHAQLLGYKLHRLKKTAPALRKNFVDLTEEVAVFHGGSVTSIPLWGRKQTTTPRTIYAMDFGSSLDEGWRRLEGADASAVTLLGSGNEMRNTQGTVNCKTARFMSMEADNSQRAGEVVCFQVELGVTTLKEKQLLSLVDVFPVAMDVRGLYEIFDVDGPRTLSLIGVERLRHWQLVSIIPKTMRSPPTAVELAQGAGSAVTAPDTYAISVFPHSTVTPLRRVDAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P298</accession>
    <name>A0A2X0P298_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C002g01708 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C002g01708</name>
        <name evidence="3" type="ORF">BQ5605_C002G01708</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY34967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P298"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="502"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="717"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="790"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="563"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="731"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="755"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="793"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="827"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="877"/>
            <end position="890"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY34967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="911" mass="95062" checksum="F9E1784D4835F406" modified="2018-09-12" version="1">MPFVTSLYKTPNAPLNLLHHVKQTTSRSAGLPKLCESSHHLDFDGAAPRAPRPQLLRGMRRRVAQKGEGAARPRNTPFIAADIDDPFLSSFIKATSASAYSSGTLFGATAAVQRPPRLQHAPEAKAIASDDTNTSSSSTLPTFRALASNSASRLQRAHIVRSTPHAKRVPLSPIKRRVVPARRKRGDEGDEDESGPRRRRKMNDDDDGGEVGELEPYARTFEFELEEDTHFAPFEEGESSLRLAGETDGNEDQHTLDDDILPWNEHESTDQLTPDEPGILGTHAERRAQADVVIVASTEDGDRIGQPLGKRATTTTRDRRPSRATITAVSTRRIRATPPQITSSVDDAFSRAAAALSSRRAANSAASSSIRSLVFASFSQAAASVESRSRVEASISASRSRAQAASVASLFSAAADSISVRDAGGTTAAATSALSSTLAASASAASSALASTATQTSFSITSTSLATSLSKTGVLETSSTASATSGPTTAASTSSNHRLRDILLPALLVPLGLILLAIALFLCTKRRNSKYKAGTAGNESSWGGSGNDGAMTGAPPAAALMAAAAAGTSNSRSGSSSNNPSQDSFGTSPSAIGVAYSGVEPRSKWGRRSLTDVIAGGVRAAEVGGSSRGRGQVTSTTSSFGGGRQASMTGISDYAGTAIDYQPGQMRPVATPSIFSASMSESNPGTPVFQQRYDSPQHYDPFAPTIIPVAGAFAHDSSSANQEDYEEDYGDDRGSFTSRDSRDEFDPFARQDPNIGGIAAQGAQPAVPWTEQAGLGYLSTPVLQPPAFERAETAQTAHTAVTARTHQTGDSADVYQTDTAPSGAESGIDDTSDEELLGTPTVIQQPVHFGSSGSSNGESGNGSGSSRGSVARANMDNRPSSSHSDRSTGTPRLGMGHGNVGGVRRGDGSWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P4R5</accession>
    <name>A0A2X0P4R5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C004g02931 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C004g02931</name>
        <name evidence="5" type="ORF">BQ5605_C004G02931</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG16 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY68930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P4R5"/>
    <dbReference type="STRING" id="796604.A0A2X0P4R5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22887">
        <property type="entry name" value="Atg16_CCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045160">
        <property type="entry name" value="ATG16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013923">
        <property type="entry name" value="Autophagy-rel_prot_16_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19878">
        <property type="entry name" value="AUTOPHAGY PROTEIN 16-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19878:SF8">
        <property type="entry name" value="AUTOPHAGY-RELATED 16, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08614">
        <property type="entry name" value="ATG16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autophagy-related protein 16" evidence="4">
        <location>
            <begin position="8"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="219"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="122"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="220"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY68930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="261" mass="28984" checksum="D409D50D27EC782A" modified="2018-09-12" version="1">MSPWLEAIRSQLIERDERESSHRTLIAHSQRLAQHAAMLHRRNQALLNASLGQNSGGTGAGTVGGPGGTSGGQTTSGAVRGTAGTNDAVRQAMITSLESQLASTRHELSEQYKIQSTNAQRLLSLTDQLREFEDKGREEKDELRRLRTEVEGLRDRAKWHKEVVQEKERQLVILQDDLSALELELNQVTKQNQDLKTDNAGLLQRWLEAKNDEARRMNELFSTETTRAKGMSSSPIPQPTSDEPPPDITVSTEAEEPAIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P557</accession>
    <name>A0A2X0P557_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C004g03071 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C004g03071</name>
        <name evidence="2" type="ORF">BQ5605_C004G03071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY69860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P557"/>
    <dbReference type="STRING" id="796604.A0A2X0P557"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY69860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="118" mass="14048" checksum="FD59B1A9F604BD99" modified="2018-09-12" version="1">MREKGARHLHLCHLASPPHSVSAPRHRNTTRFIEAGSSSKKRRLSKVITLEDDEDEDEDEDEDEWRKKMRMSTCRHVEVFMCQIRQFHVSDQIDLLRSDQDQINQVRIRKIQIRSDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P5C1</accession>
    <name>A0A2X0P5C1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C001g00255 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C001g00255</name>
        <name evidence="3" type="ORF">BQ5605_C001G00255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY45161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY45161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1284" mass="144303" checksum="81B7F553AF6DFDE5" modified="2018-09-12" version="1">MSPVKQKKTSAYDLVEHEWIFAIFDALGAPAAFQRVLRMLYSGDSTTARYIINGFLTPPVRLTCGLGQGDPASSSVWDVVFQPFLDALHRRGIALNLSLPTIHPYPQSRAITSLAFADDVVVAVAGSESLTLLDDLALDWRLATNGRLNTDKTVVLPIGCRWEAGDRPLVVKAEGESLEWIGLSFDPTGNTELANVNLVARLEAVLDSARDRGLTHHTRAFYVNRYAIPKILHILSADIPPLEVVKELDRILVDFVRGGKRRSCYGKDVVFTPRFKGGLGVMRMQDVVDSVAARVWDVLLGGSDAIWQGLARAAIVRTHPAPDFDLATDAWPCDYTPIRTDLHPRWQAVLKIPSTHNAQVKPRTLTLANLLALPIKLHTLHYLPGAPAVSRSPYDADYAAFAIYAKVADLFRRELYPGGGFHLWTPPTDVVVSNSEYDQRGRPQREHIVAWYRHAINRLRFTPIAQPVAAVRINGPPRVRPRSEVRPTTPLESILPHPIDPPQRLPRPALPDQSTQYNLLSMDRPYTIRRVRRVLNAKAFTDTIGFRDSLQPDDLKGFWKGVNSKALTAREREVWFKLVRNFTPTRSLQFHQKHDDSPACLVCGAPKDDREHYFFDCVDSGNVWIAARSVLCDALGLDTIDNTHYTAVQRMFGLPKLKASLRDQEGAGRTIEIFTGLILEMISSGRWGMQKWGTRMEGVGRRRIILEERGNRNWGQYDERFLQKKGRWDPGQRPLVVKAAGESLEWIGLPFDPSGDTELAYANLIERLEATLEGVQHRWLTHHTRAFYVNRYAIPKILHFLAADIPPPEVVKKLDDMLVDFVRGGNGRTSYGRDIVFTAKLKGGLGVIRMQDVVDAVAARIWDVLLGGSGAIWQGLVRAALQRAQSDLDLATNLWPHPSTPIPSDLHPRWRAALGVPKQQDAQVNPRTLTTANLLALPTLLGSLHTPIRGRQTIDAVHLPDYLRLQGYPKVADLYRRELYAGGGFHLWTPPADVLGDNSEYDRRGLPQRLAIAAWYRFTVDRHKNTPLAVAVAVGRLNVPPRIGTSAPLEAILPKPVARFAMEQRLLDPVLPQQASQYKLLNMARPYTIRRIRRVLNAKAFTNTLGLKGPPQPDDLRSFWKAVNSKALTAREREVWFKLILRFTPTRKLQHQQKHDTSPACLVCEAPVDDTDHYFFGCVDSRNVWIAARGVLCDALGCDTIEDAQYTTLQRLFGLPKLKAKLSEQEGAGWTIEIFTGMVLEMISSGRWRMQKHGTRMENVERRRVVLEERMKLRAGGARGGRWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P639</accession>
    <name>A0A2X0P639_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BQ5605_C001g00545 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C001g00545</name>
        <name evidence="12" type="ORF">BQ5605_C001G00545</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY47586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P639"/>
    <dbReference type="STRING" id="796604.A0A2X0P639"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF15">
        <property type="entry name" value="MIR1-PHOSPHATE TRANSPORTER OF THE MITOCHONDRIAL CARRIER (MCF) FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="32"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="139"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="240"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY47586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="345" mass="36305" checksum="63D6F3781D3ED2CD" modified="2018-09-12" version="1">MASVPSSNETPNLTGIDYAKYFSAGGLCAMLTHGAVTPMGTSLTETTARPALQAPNVVKTRIQLDPKLGKLGMVGTARGIIAEESVKGLFTGFGATAVGYLVQGGAKFAGYEFWKKKFVDAQGGYEAATPNRTTIYLGSAAIAEFFADVSCDQFRHILLTPLEAVRIRTVSDRTYASGLATGFLRMAREGGVSEMYAGFVPILFKQIPFALGQFVTNEWAHETVYKQLSAEKRKNLSVLEETGITLGCGVVAGISAAVLSHPADTLLSQINKGKGGKGGIFKRLGTLAAEAGPAGLFSGLGPRVVCLTGHINVMTAGLVSAQFFLYGTIKKSLGARPGIEIHKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P6R3</accession>
    <name>A0A2X0P6R3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C005g03513 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C005g03513</name>
        <name evidence="3" type="ORF">BQ5605_C005G03513</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GID4/VID24 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY76740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P6R3"/>
    <dbReference type="STRING" id="796604.A0A2X0P6R3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045721">
        <property type="term" value="P:negative regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018618">
        <property type="entry name" value="GID4/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534:SF3">
        <property type="entry name" value="GID COMPLEX SUBUNIT 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09783">
        <property type="entry name" value="Vac_ImportDeg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="217"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="402"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="300"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00061469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY76740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="492" mass="52808" checksum="AF7FF5E5D30D41F5" modified="2018-09-12" version="1">MTIGGDDLHYEPLLASPVFDAPPTSVHRGPLHPGACWEGVQKSGRNVYKVKVDISTVDLNEGKLSGMLQIRHLTPELESLVTFFEGEIIGDGTGFLTSKWGATDKTLRSTLIKPTLTFKHSNRPFLFMRWKEQFVVPSSHAQNIHGASFAGFYYLCLGFDMPADGAHVCPDSVRTSSPPLRGAARTRSMSSEISPAALGSVRSPVLVNSTDHEMVFEDESADGLRPPRPQEARAPLSRPAQPRRASNSGFSYASAVRGSLSSSQPFRTSTDPGRSSSLSSDVAMPKEVESTSEAGAISASHGSSNLGATGNISRFNGPSDSIPLLLSNVPLPISIPTPIGTTADDFPPPSSPPLGSHVSFGSLPTARHNSMNSSFMSSSPPAGGAAWGGRGIRNTINAAVLGSEAREGHSTRQRSRSFNTGSNRPHGPHERSSSINNQMSGSGKASTNWGYQSWMNCEIKGFYFFRHSEPYQELSLRYVPKARGTTQAFAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P6T0</accession>
    <name>A0A2X0P6T0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Spliceosomal protein DIB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C001g00745</name>
        <name evidence="8" type="ORF">BQ5605_C001G00745</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DIM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY49164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P6T0"/>
    <dbReference type="STRING" id="796604.A0A2X0P6T0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02954">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004123">
        <property type="entry name" value="Dim1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052:SF5">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEN 4A, 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02966">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017199">
        <property type="entry name" value="mRNA_splic_U5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01410">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="38"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR017199-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY49164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="167" mass="19210" checksum="7812877B58CB6CE8" modified="2018-09-12" version="1">MSYFLPKLESGWHVDQAIMAEENRVVIIRFGHDWDPACMTMDETLLGVSEKVKNFAVICTSDTETWPYVTGSTGKQISIFSLVDTCDITKVPDFTKMYELYDPCTTMFFFRNKHIMIDLGTGNNNKINWAMENKQELIDIIETVYRGASKGRGLVVSPKDYSTRYKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P7C5</accession>
    <name>A0A2X0P7C5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C006g03771 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C006g03771</name>
        <name evidence="8" type="ORF">BQ5605_C006G03771</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY53537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P7C5"/>
    <dbReference type="STRING" id="796604.A0A2X0P7C5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044986">
        <property type="entry name" value="KIF15/KIN-12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37739:SF16">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37739">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIN-12D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="65"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="361"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="817"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1149"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="683"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="911"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="992"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="172"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="826"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="847"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="857"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1172"/>
            <end position="1184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY53537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1212" mass="131370" checksum="2EE526D2D3E7F833" modified="2018-09-12" version="1">MCTRQMKAEGAPAHTPPNHGGPTANTSVNSDEWQLSVTEETSLIFEEIDSSLCDVEEQSARLIEISESLPKQSPTPICLASSQQRSTSGPGRSPRPPQVQFSPLSLAPSPLLGLPPPPLPALLDPTSANSDATESPTSYRTRQASAPSVRTILKVPGTPGTGRSVRFTSSARRIEDHSPSARPDRSTSLTSDGGSGEQESVLRVEKEEDREEEISSSEEEVSSHLVASFLSRLQAVIPSPDSSLASSVSRLASPGDQSVVEATSHRPAVAVTSPTSSDYAIDLSKHLPVVGLGIARSVRETRDLFDESNPFAGTSISVLAASTNQDLGFTSRPTVARLESEGARFAPGLAALSQVDEAAGVNRLSRPSASDPPRLPPRIKSLQPSNPGASPPMPADKAPDMLAMGRDQEASKPLGCAAAHITVSDSCSNEENVTPPSAISRASCIGSSLYRIFMQKRSEGSRIAADEWGRLVHGGQAGDKEPARLMESAQANTPLGRPPNLSPDLRPRDQYALEELKHSGEFGTPSCTSIEGCSSDLANDAGDHQLDDFYFAAMPLTYLSPIPELSEPNTTVESVRLPLCDEAASRIGRAAPFRGKSGSLYITSTTSSLASVTPEEHPSFALSLPPTSMNDTSSIDFQESFDAFASLVATYDVWRGHTTAQKSDIASLLAIIRTECQRKDAVLAKLAGRNETLERQLQHITATLDETNHTLLDRDGGPEGVLKRLLRKNEALVRLVSKLTEELEARIQQQLSNKNKREMDLRDSRAELLKAQDAARDREIRLRVVQATQADLSETHSRMQQQVLQLVRENEALRQERDDARANWRQDVNTIGGQSDKTVPGNEGQHSRASNEQAQKTSAANAAHSASTNMGAHKNAEEMASVRGSPHPGMRSTDELCTAPNTERGNMAITYEHANDRMEWMERELRQAENTSQDLQARLLEATVLLEEQDVRSERFEAELKVKDDQIALHTKAWKEHQAEITRLMDSISLIEQEAVNKVHLAESELSRVQNELGAVIESKEQQLETVKNDISSHAARVVKLDNECKTNAIMVGMLRNRLAVRDGRYTALKNLKAELESDILGLNIALEAKQQEASAWKRQLQSSRLSQMSITTSKTAQNQHQASDIPRVAVFVGQPPLALTDGGLCEATPSQKGRIRKPSLGFGSSSRRDATSLPTLSSTPKSSIHLARNAGSKENVAPAFVRKRAASLILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P7T7</accession>
    <name>A0A2X0P7T7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C008g05124 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C008g05124</name>
        <name evidence="10" type="ORF">BQ5605_C008G05124</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P7T7"/>
    <dbReference type="STRING" id="796604.A0A2X0P7T7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF2">
        <property type="entry name" value="CHITIN DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="NodB homology" evidence="9">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY79405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="237" mass="26771" checksum="94E9076B85E44ABD" modified="2018-09-12" version="1">MVHQSLISDFVSQYTYSKDIGKLFKRKGVEGKATFFINGYNYGCIYNKENVNALRARHHEGFEFGLSSLCMLCHADLVNLSSVQIVKQVELLETAVERILGVRLGMFIAPYDSIDEKAAKVIRDKGYKIVRWSLDSGDTTFYLGRPQSSVNLIRKWIKKASGKSGIGLFDETKADTVYKVLPHSIDLLKKSGYKLVTLSECLGVEPYQKGHFHRSEPDKTWTCGEFLDRLKRSGSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P8W5</accession>
    <name>A0A2X0P8W5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g04302 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g04302</name>
        <name evidence="2" type="ORF">BQ5605_C006G04302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY57746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P8W5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY57746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="124" mass="13579" checksum="4905365FC04DC8A1" modified="2018-09-12" version="1">MEGCVALRLWCTDDAEQTTADGLPDLTSFARSPGDTIDETDDNTNEGVDFDMSDHSSDDLSHYSIDATDNGAFVLEEWEFNAEDDGSDDETWEIFNGCLESKALVPKASIQTDDASARVLLPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PAE3</accession>
    <name>A0A2X0PAE3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C007g04812 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C007g04812</name>
        <name evidence="3" type="ORF">BQ5605_C007G04812</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY63626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PAE3"/>
    <dbReference type="STRING" id="796604.A0A2X0PAE3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="76"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY63626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="347" mass="38274" checksum="52384C0669F6FF69" modified="2018-09-12" version="1">MTTSKTSSAPQPGPNEAPPSYNLATTSPGHQDRSHLSVPDREEDDLSTDDDEEDHLGRTTGVDEKTRRSMETELMELPKGWVREFDASSQHVYYVDTTKDPPRSIWVHPYEVSEINTFDRERLKKYVQCTYETCKLPTGREFAVNSPQKAVATVFSGTPSLTSDISHFHQPEYLASIPDTERSRLFNESDPQYEQGSHSAHASTSTGSSSHPQKQPEKRSFGRKLKDKMTNSTHEERQAERKRQAEEEMKRHQAYIRRRKAMLEASQNGTYAPTYAAPQTMYVRSGGYGPYGGGFGGYGRPMYGGGYGRPMCGGGYGYGSPYGGRGLGGAGMGAGLLGGVLLGGLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PAP0</accession>
    <name>A0A2X0PAP0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C004g02605</name>
        <name evidence="9" type="ORF">BQ5605_C004G02605</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY65916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PAP0"/>
    <dbReference type="STRING" id="796604.A0A2X0PAP0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043323">
        <property type="entry name" value="PIN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45995">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13616">
        <property type="entry name" value="Rotamase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PpiC" evidence="8">
        <location>
            <begin position="36"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY65916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="146" mass="15669" checksum="32B0391139A2C168" modified="2018-09-12" version="1">MAPSKPSGNKGASKGKGKSTSDDADRPSSGGDLKIANSLKLRHILCEKQTKSLEALVKIKAGTSFDAVATAYSEDKARHGGSLGWMTRAQMMGAFQDVCFTIPVSTCASPIYREIKTKHGYQSVFSPGGYHCLFKKLVSTRLTHPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PBK9</accession>
    <name>A0A2X0PBK9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C004g03056 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C004g03056</name>
        <name evidence="3" type="ORF">BQ5605_C004G03056</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY69750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PBK9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026960">
        <property type="entry name" value="RVT-Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13966">
        <property type="entry name" value="zf-RVT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase zinc-binding" evidence="2">
        <location>
            <begin position="67"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY69750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="188" mass="22026" checksum="62CA747DF1D97E6D" modified="2018-09-12" version="1">MMNKFYQKKKKKKKKKKKKKSQSQYKLLNMARPYTIRRIRRVLNAKAFTNTLGLKGPPQPDDLRSFWKAVNSKALTGREREVWFRLILRFTPTRKLQHQQNHDTSPACLVCEAPVDDTDHYFFGCVDSRNVWIAARGVLCDALGCDTIEDDQYTTLQRLFGLPKLKAKLSEQEGAGRRSRSSRGWFWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PEE2</accession>
    <name>A0A2X0PEE2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C022g09422 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C022g09422</name>
        <name evidence="2" type="ORF">BQ5605_C022G09422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PEE2"/>
    <dbReference type="STRING" id="796604.A0A2X0PEE2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="621"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="724"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="791"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="752"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="791"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ22057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="850" mass="90353" checksum="86507119920FBFF1" modified="2018-09-12" version="1">MERTLLVLFGPQAPLDAIQSLLNNHGFRRVAHQSCVGEELEEAGLELGLGTGEANGQALNAADGATLHEVLVLECENAVRRMKELAGEGSGALNKNALSYTYPDLKLHCSPTVSAAQLTIEALFPKLDAIYTPSPADKTTPIPASPSFGATAASAVNATPKPFALSNAAYQIPERIVRSGTIKLSPRIERALREVDQREALQKQQQHQRAAAGSSLGSIETATNGFEDSSSEKTSFDGSSASSLASEFQQDELEAETDGPESEDRFEATSQDGTIEEDYATHEEEVDEADLILQEGAVEDYADEVIEAEQQQFDDNADVDHAQVDCDLNDAESVIAPESIFDGEYPMSPVSIGSDFGDENSPVRVRREDTTYSLESLTSPSRVFRAQPVASTTHQAPKIQPRMTKAAALRLGIELPAPAPRASLVANLSTPQPARVVEMPKSLGAPSITPRATKSSVLRVGSTSVSGRPSLGASFVAPTSIRREAVGTAERAAMSRRESLSAQPTVASLINKPKFEVRLSKTAALRTGVVPAPPSTPGSTARRRSNLVGSPESPSTSRDRAIVILGDLQEEAGAITRPASSLGGDRPRPSVSVSSTAPPKIVPRMTKTAALRTGVDLAPVPRRDRSSSVVSDDSRLRDGGLGRMRRESVAVASTARPAIEPKMTKAARLRAGLGIEPSPSAMRRQSMSSSDHVGLVGPHRRQSIVVQAVVRPPSITPRLNRSAMLRANPDGAMSPIRPRSSLGISGMPRPGSSLSNTSSLARSSHKPSTTRSGVRMACARSPIIAPHMNKSAALRASSQSQRSPPRVENVNRAGWNSTPKTVARHVPSRPSTVMSFVNDGKRALSEMNAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PFU4</accession>
    <name>A0A2X0PFU4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C039g11824 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C039g11824</name>
        <name evidence="1" type="ORF">BQ5605_C039G11824</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000060">
        <property type="protein sequence ID" value="SGY90727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PFU4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY90727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="111" mass="11499" checksum="1835815E2DA268C9" modified="2018-09-12" version="1">MAASTASTVDLPRSLSSIDLLTVNAHSTIASFSTHLPSSPIDTRVWDKNPGWVGVARRPVSLFDGRAVQTTLQVNGVSIGSDNADAIVNSGTVYMVLVDAVTAADFASIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PFU9</accession>
    <name>A0A2X0PFU9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C039g11834 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C039g11834</name>
        <name evidence="2" type="ORF">BQ5605_C039G11834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000060">
        <property type="protein sequence ID" value="SGY90871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PFU9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35317">
        <property type="entry name" value="OS04G0629600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35317:SF23">
        <property type="entry name" value="OS04G0629600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY90871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="287" mass="32424" checksum="DAF3D9720071191A" modified="2018-09-12" version="1">MSPSETIAQESGEIKIAKLGKDNYELWSIRVEAYLESKGYASVLEHGHVRPSDVSLAEWRTMHGLDASVTDTQVVVNLQKKDRSARALIIQCIDDANLKMVKSKTLSAKDIWDKLRQHHEGNAKPFKIRTLLMELSNAKYDEDENMGEFLKSMIDKADQLDDLGQKFGDEAMIAYILQALPPSYEMLKQAIRLGENRSVDHVINRLTDEYTERKLLGKFDKLLKNAGALAVQSTQASRDPNCVCRGCKGKGHFAMDPECPKYDAKKNHGRARNRNKKKKQDSKESAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PGW0</accession>
    <name>A0A2X0PGW0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C027g10439 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C027g10439</name>
        <name evidence="1" type="ORF">BQ5605_C027G10439</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PGW0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ28756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="47" mass="5283" checksum="1856684A93DFF445" modified="2018-09-12" version="1">MPQVDRFRVSHRTFPSDHRRTRISLCQTAGTTALCTILITQRASVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PJX2</accession>
    <name>A0A2X0PJX2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C021g09286 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C021g09286</name>
        <name evidence="10" type="ORF">BQ5605_C021G09286</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M43B family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000083">
        <property type="protein sequence ID" value="SGZ20554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PJX2"/>
    <dbReference type="STRING" id="796604.A0A2X0PJX2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008754">
        <property type="entry name" value="Peptidase_M43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47466">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47466:SF1">
        <property type="entry name" value="METALLOPROTEASE MEP1 (AFU_ORTHOLOGUE AFUA_1G07730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05572">
        <property type="entry name" value="Peptidase_M43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M43 pregnancy-associated plasma-A" evidence="9">
        <location>
            <begin position="140"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGZ20554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="247" mass="26693" checksum="2A5F4ED07A76208E" modified="2018-09-12" version="1">MPDATFAGSAAQEGFLSTELIHQQIAVVNSIFTASGLPMNINLAQTTYTNNPTWFNYGGDFDSQTEREVIKSLRVGGAADINVFTVRKPRDGQVPIMGYGTMPQQVKDFFYLDAIFLAFDALPGFNSEGGEVLQGKALAQHSLDSELGHHILGLPHTFEGGCSPINDGIADTPPQRYQTLGCEYNAATQCQAGVPYVAHGNDPKAKLSFNLMDYSNEACRGGLTPGQVAAGLENWYRYRAQNASMKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PKF7</accession>
    <name>A0A2X0PKF7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C022g09527 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C022g09527</name>
        <name evidence="3" type="ORF">BQ5605_C022G09527</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PKF7"/>
    <dbReference type="STRING" id="796604.A0A2X0PKF7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013955">
        <property type="entry name" value="Rep_factor-A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08646">
        <property type="entry name" value="Rep_fac-A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Replication factor A C-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ22697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="114" mass="13171" checksum="A9AFB7F429678A6B" modified="2018-09-12" version="1">MRSSYIVSFAVYDFTNQIWLSGFNDSDSEMSLPLFGRTANEMQQLREENEDEFPIVTNKALGTMYDFSVKAKADSFNDQVNFRYQLQKAAPINWVEDAKPRSSPSRSRPCPRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PLL2</accession>
    <name>A0A2X0PLL2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C023g09648 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C023g09648</name>
        <name evidence="2" type="ORF">BQ5605_C023G09648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ23862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PLL2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053203">
        <property type="entry name" value="Cisplatin_resist-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022024">
        <property type="entry name" value="DUF3602"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693:SF1">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12223">
        <property type="entry name" value="DUF3602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ23862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="146" mass="15574" checksum="38F7EDD34A4B73D6" modified="2018-09-12" version="1">MGLLDKVKEKLGDGHAHSTPTADDTQERGRFMASTGRGGAGNMSRSRARQADESPEVIAAARSRSQSRSRAAHHGHDPHVTAGRGGTGNVRSTSKNAESRERQAALDAEERVVEKKYAAEHAGEEPVHGRGGIGNIPHHTHHNEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PMD4</accession>
    <name>A0A2X0PMD4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="23">BQ5605_C025g09948 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="24">BQ5605_C025g09951 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">BQ5605_C025g09951</name>
        <name evidence="23" type="synonym">BQ5605_C025g09948</name>
        <name evidence="23" type="ORF">BQ5605_C025G09948</name>
        <name evidence="24" type="ORF">BQ5605_C025G09951</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000087">
        <property type="protein sequence ID" value="SGZ26773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000087">
        <property type="protein sequence ID" value="SGZ26781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PMD4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0229">DNA integration</keyword>
    <keyword evidence="18" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="16" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="15" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="16" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="17" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="22">
        <location>
            <begin position="525"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="788"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="951"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="21">
        <location>
            <begin position="798"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="SGZ26773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="SGZ26781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="973" mass="106262" checksum="3FE601A94C5D2690" modified="2018-09-12" version="1">MDDTSPPLATGVHPTFPADQLAALTSLLSGLTTAASGTVTTTTSSSTTRPAFPKHARLDGPKTFANWTRQLRLCLADDIRSYVLDGIVPVDWTPSQRSARDVVARELLANSIDSAEVSAVLDAIPTADLTAPKMYSTLKSRYAPDDATRTLELFSRLWSFRPMPGTVGEFDGWIMEFKAIAQEIIDTKPTINDVLATLLLAIAHPSLESFKASFTNEQRTQRALPAIDSLADRMRVQLRSTNVPSTKSALLASSSCPTRPKCLACRSPSHRVAECPVRAKHPPPGPCRSCKQNHWSFDCQQALENGKKADTANSIADSQHHVGCIATSLLARRRQLRTNSFVVDSGATSHMVSDKSLFTTYRHIAPTKIGGIAGGIHAIGTGNIAFVAASGHPITLTGMLHTPGLFVNLLSVSRLCDTDDVRVAFTKHGIDIDKDGNNIAEGTRLEEGLYLLDADHSKCQHLALLSRSQSSVPLLTLHRCLGHLAPSSIQKMVAAGLLEGLGAGYSDEEVEKFVCNACLSAKGHRLPFPDSDSHASERLGLVHSDVLSLPERSLTGKRYLVTFLDDYSRKLWAYAIGHKSEVFSVFKTWLAEVELETGATLKVLRTDNGGEYCSRAFTEFCKARGTRRQYSIPRTPQQNGRAERVNRSIVEGILALLADAHLPKTFWEEAAAYFVYCKNLVQHSALDKATPNSVWQGGRTTASALHPFGCAAWLTVAPELRSKLDPKAVRVLFTGYDLASKAFRFYNTATKKVTLGRNATFLDTEFPGLRCDSAEQDDDTHFASAPFADPHTTVKPWTPLPQAPPDPLDAQPPDFSTYREPASAEESPDELDLIGRHSCDESPDEIDFLARHHRAFIATDNDNPEAEAIQPVKSITSDPQTWREAMSSDKREVWAKAATAEFNSMRDDFKVFTIDDRSTVPAGATVVTSKFVWKTKRNALGEITGHKCEESTLRSAQDLGARSEPGADLGARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PPV9</accession>
    <name>A0A2X0PPV9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C045g12191 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C045g12191</name>
        <name evidence="1" type="ORF">BQ5605_C045G12191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000115">
        <property type="protein sequence ID" value="SGZ31515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PPV9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ31515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="57" mass="6458" checksum="E5EB694BEA5FEAFA" modified="2018-09-12" version="1">MDILYNLLAAPLLDVRVSELFASSFDKPDTRIQLSWSTDKPLEFECLVLRAVPEHGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LNH1</accession>
    <name>A0A2X0LNH1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C011g06236 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C011g06236</name>
        <name evidence="1" type="ORF">BQ5605_C011G06236</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY11691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LNH1"/>
    <dbReference type="STRING" id="796604.A0A2X0LNH1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY11691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="42" mass="4428" checksum="155F7408137BC4E9" modified="2018-09-12" version="1">MSSPQQRLAQVSGAISGSYPQGLLKDEVVIIVATRTKSVALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LNZ1</accession>
    <name>A0A2X0LNZ1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C011g06403 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C011g06403</name>
        <name evidence="1" type="ORF">BQ5605_C011G06403</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LNZ1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY12146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="162" mass="17969" checksum="7501D92FC2D4505B" modified="2018-09-12" version="1">MPSDTTSSALTVLQADYAALLAKITHLEALQSAASTPAKQEKPTDGMPSTIVVPEAYMLKGRKNFVEWDGFLNMFLPDNVYNYLTGGRDKVKWTNAYYAHGQEYASRVLIASIDPICSSDIIPIRQMKGTAHKCWLKLASRYHPVTACKLPIQERHASKSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LPM0</accession>
    <name>A0A2X0LPM0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C011g06623 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C011g06623</name>
        <name evidence="9" type="ORF">BQ5605_C011G06623</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LPM0"/>
    <dbReference type="STRING" id="796604.A0A2X0LPM0"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008841">
        <property type="term" value="F:dihydrofolate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF0">
        <property type="entry name" value="DIHYDROFOLATE SYNTHETASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur ligase central" evidence="8">
        <location>
            <begin position="58"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY12836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="508" mass="54486" checksum="4A2EA91476BD3F51" modified="2018-09-12" version="1">MSSSNQESNGPSTSALSSPNSPSASDMSSSGILLGLARIHRLLSCLHSPHLSTPIIHISGTNGKGSVSSYLSSVLTVAGLRVGRFNSPHLVDEWDCLTVPHDRTVPRKIYESTKAQVMHTNKLEQVGATPFEILTATAYSVFASTEPKLDLAVIEVGMGGATDATNVVPADKTLMSIITSIELDHQKFLGNTIAEIAEVKAGIIKQGTEVVLAQQSHQEVQDVVKRIAKQQEARLYIAGEALPHHAITNASTGNSSSPTSSLVSIPLTPISFHPPSLPSTRSTTLPDSIRANLPLPGSYQYQNSAVALLAVELLRTSSRPLSLVPALSNVSPLAYRKGIEVTRCAGRLDWVNLPSELSRTEHPILIDGAHNPSAAEQLHQYLHTLAEDSAPTTLIIAISAPRPPTVLLEPLLRPRGSIRKVVCVGFSRPDGMPWIEPTPPEEIRELLLRDPAFEHVQEVQVFGDVEQALKSLGEADRVVVAGSLYLAADVYRLIRRGREGAAEAEADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LT67</accession>
    <name>A0A2X0LT67_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C011g06310 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C011g06310</name>
        <name evidence="2" type="ORF">BQ5605_C011G06310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY11895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LT67"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY11895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="55" mass="6153" checksum="8BF1B038D1A23FB8" modified="2018-09-12" version="1">MAEALQAAGKDTANDRRDQCEVNRTRSRLRRTSHLGNADHLRRGSWNFALATSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LTJ3</accession>
    <name>A0A2X0LTJ3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BQ5605_C010g05978 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C010g05978</name>
        <name evidence="12" type="ORF">BQ5605_C010G05978</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LTJ3"/>
    <dbReference type="STRING" id="796604.A0A2X0LTJ3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF17">
        <property type="entry name" value="HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="451"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="22"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="542"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="552"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY13792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="564" mass="60618" checksum="78E979C459820D8C" modified="2018-09-12" version="1">MVAVSMPVAEGPRPAGKIAVAMTVFAAFGGFLYGYDTGYISGVKEMPVFARLMGVPNTDPATIATAPYVLTSATNALITSILSAGTFFGALSAYPAGDLLGRRFGIIAFLGLFCIGVALQTAATTIGPFTAGRVFAGLGVGGTSCLVPLYQSECAPKSIRGGIVSCYQWMITIGLLIASIVVERTKNINSEASYRIPIGLQFIWAFILGGGLLILPESPRWLLMRNREEDAQRSLARVLGTDVDSAAVNEEFAEIAAALHHERSLGGSSYLDCFRNGEGKNGLRTWTGIAIQALQQLTGINFIFYYGTAFFQNSGIENPFTITIATNVVNVGMTVPGILLVDRAGRRNMLLYGAIGMFVCQFIVAAVGISVSQDNLAGQRVLIAFVCIYIAHFAATWGPLAWGRFLPPASSSSGVLKGHSDSRPLRISPPVVTSEIYPQQIRGKCMSMSTASNWLLNFAIGYSTPYLVDKRPGSAGLGSNVFWIWGGCCVLCTIFTFLCIPETRGLSLEQVDILYRNSTPVRSNAFRKRIIAENIHDDDKEAYAAPKNTGTVEHKEEEAGMRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LU51</accession>
    <name>A0A2X0LU51_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C014g07665 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C014g07665</name>
        <name evidence="4" type="ORF">BQ5605_C014G07665</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY19503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LU51"/>
    <dbReference type="STRING" id="796604.A0A2X0LU51"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054491">
        <property type="entry name" value="MGH1-like_GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF10">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 63 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22422">
        <property type="entry name" value="MGH1-like_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannosylglycerate hydrolase MGH1-like glycoside hydrolase" evidence="3">
        <location>
            <begin position="765"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="2">
        <location>
            <begin position="1042"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY19503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1275" mass="144125" checksum="858077F541DA2E19" modified="2018-09-12" version="1">MAPVKLDPVVKVSGAPSSSLSERRKSDAARTSPPSMIMLNSSSNSSAASAHVVPREACSPSLNATGTKVALESTNTSAVSTPSAGPAVSGRPTRSGTVKKSSKGSSSKQPSRRQDTVTDTGFEGDVEQHGQANDFVDPDDTDEEATTGTSARGSRPPLANAGRGAGSERVSEQIHASFPANFPDEESVARSTFRNRNPSMSSHQHPGRLPLNQRMSSSRSASTGRPRASSISSTRSHEATSHPFPTPGHKAHGGAPFDGWKSVEEKRLDEDEAKEKHWKRWGPYVSERQWATVREDYSANGDAWSHFPHEHARSRAYRWGEDGLAGISDNHGRMCFSVGLWNGVDSILKERMFGVTGHQGNHGEDVKELYYYLDSTPTHSYMKMLYKYPQREYPYEQLVRESSNRGRDVGEFEITDTDAFEDNRYWDIFVEYAKDEDCAEGISIRITAYNRGPDPATLHILPQLWFRNTWSWPKDKPEGDKMPSLQQVGEGVVEAKEPHLGRYYLHANSSPAPVNPRQKGEDETVFTDEIVVPELLFTENDTNFKRLYGGHNVTPYVKDAFHDHVIRKHRPALPKVAKARASAPDESEYDSDKTTGEATPRTEDGSRTSYVESDTEEEQEDDREFVNPEKKGTKCAAHYVFRDVPGNGGCAVVRLKLTPKTAEEDASIQDEESFDWVVEERRMDSDEFYSRFNSGALSDDLRNIMRQALSGMLWTKQFYMFIQKQWIEGDPGQPAPPAERKWIRNNDWKHMHIEDVLSMPDKWEYPFFAIWDSAFHCIPLAMIDPAYAKKQLDIMTREWYMKPDGALPAYEWNFSDVNPPVHAWATFRVFKIERKMHGKEDLHFLERVFQKLLINFTWWVNRKDEGGNNVFEGGFLGLDNISPFNRSERLPTGGTMRQADGTGWMGFYCLSMLNIALELAKHNPVYEDIASKFFEHFLFISDAMTFEDGQNEMSLWNDEEGFYFDAITWGPGAVKQLPVRSLVGLIPLYATLTLEPATIKKFPGFKKRMEWFIENRSSMARRNMANMSLGGKGDRRLLALANEDRLRRILERMLDEQEFLSDYGIRSLSRHHKEHPWAMDVNGEEFSVHYWPGDSHSAMFGGNSNWRGPIWLATTFLLIESLQRFYQYHGTAFKIECPTGSGDEMNLANVADEIQHRIIHIFARDHEGNRACNGGSEMLNKDPHFRDYVPFHEFFHADSGKGLGASHQTGWTGLVAYMIWMTGSTARLPRTPRTPKSAASHYFDEIPATPGATDVEYSDAWSGFMSASDMSPSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LUM0</accession>
    <name>A0A2X0LUM0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Autophagy-related protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C010g05977</name>
        <name evidence="10" type="ORF">BQ5605_C010G05977</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LUM0"/>
    <dbReference type="STRING" id="796604.A0A2X0LUM0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14009">
        <property type="entry name" value="STKc_ATG1_ULK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048941">
        <property type="entry name" value="ATG1-like_MIT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022708">
        <property type="entry name" value="Atg1-like_tMIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12063">
        <property type="entry name" value="ATG1-like_MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21127">
        <property type="entry name" value="ATG1-like_MIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="46"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="359"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="467"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="553"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="611"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="766"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="359"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="390"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="402"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="484"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="571"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="581"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="625"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="779"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY13789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="993" mass="107963" checksum="99BCDAAC46AFBC56" modified="2018-09-12" version="1">MAPSAAPPSTQRPHADGSSSSRRRQSAARQQQQHQHDDDDDRIGPYLIGEEIGRGSFATVFKGERYDNRAEVAIKSVIRSKLTIKLLENLESEISILKEITHRNVVELKDCLKTETHIYLIMAFCSAGDLSVYIRKRGEVVALSASNQGLLPAQSRSLKDSELHRVLYPHPKEGGLNETIMRCFLIDALRFLRSKNVIHRDIKPQNLLLKPADAEDLAMGHPPGIPVLKVADFGFARWLPQQSLAETLCGSPLYMAPEILRYEKYDAKADLWSVGAVLYEMCVGRPPFRAQNHVDLLRKIERGEDKIKFPDEQRVEEGSNKTPTQVAPDLKALIRRLLKRNPPERMSFEDFFREAASVGTSGTASGLTTYSTDPSARRGVVPEVPSANLAAQSSTVAQSAVPVPPATSPSPPSARNPAYADTEPPPFARRPSSATPPLRPSTPGTMGSGQHKRVPSSFVAKYVVGGPSQANSGATTAVGDDNSKPSPTMTKVQEASPVFVPSAIQRSSAKNEASSTNASMTDSNDSIVGRDFVVVDKRTVEINALADELATQPKREGTVARRPSRGFLSRPLSSLGNNISPSPPSPVAPYPPTAPPSTDHIATAYPNAATPFAVPQQRPGPTPHPYSLSSSPRPLSFLSSSPRSLSHPIERFPGSPLALVGSPTAAIAKALNMASLKLFGSPTDGILVRRSSARKPLHRTAQISDPDEERILGVLEDIAQKALVLFDFADSKILQLLPPTPQTSSSTSLGTPSYFSHVAAREQQTAASNSAMNPFSAIPTPTSLPMRRTSSSSSSEPRPMGLASSAKADVVAAEALMLYLKSLAFLHKGIERARLYWTVRSPDQAPSSDFNDGELDADPRFCPNDRCLLRIPTVIFTAVQWFRQRFNECFDKADFAKSRCQDEIPESATYAEKLVYDRALEISRAAAVHELKGESPTDCETAYETALWMLYAILDETMSGSAQSAVEDEDRAVVNKFVASITARLQALRRKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LUT8</accession>
    <name>A0A2X0LUT8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C017g08390</name>
        <name evidence="3" type="ORF">BQ5605_C017G08390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY19930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LUT8"/>
    <dbReference type="STRING" id="796604.A0A2X0LUT8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY19930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="199" mass="21819" checksum="B699490540220634" modified="2018-09-12" version="1">MLQDVRSSTARFGGVTVVLAGDPKQCLPVIPKASPAQIVDACIMNADFWGEVQVLRLSTNMRLLAAADRMTETERTKAQGFANWLLGVGDGSANKTEDSIALPRELLLPATTTNSSGRKVEYFRERAKLAPKNSQVDHINDMVLDLLPGDAQTFYSADSVETKTNHCSRSTKYITLQVTGYGVRWRAEPAAEPSLKDKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LV32</accession>
    <name>A0A2X0LV32_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C016g08045 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C016g08045</name>
        <name evidence="2" type="ORF">BQ5605_C016G08045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY20431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LV32"/>
    <dbReference type="STRING" id="796604.A0A2X0LV32"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016029259" evidence="1">
        <location>
            <begin position="30"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY20431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="255" mass="27602" checksum="B6143291AF7A35C9" modified="2018-09-12" version="1">MALNSRFRAIPLLSALVALVSLSPLSVNAAPPPPTAALSDSEPKGYQGLGFYDVKDGGGRWLTYAAHNGSLGEPINIVVSGNSDSYILTESGFQDWCLSIQYAIQPDDITLGGKQRADLGDGNGPQNQTDLLRYDYNQPKLGTGLEIIYGGSHFRYWQQNGPKANSNAWFLAASVEKSLDEGHNIVHNGYDRGRDEFVGNATSHNGTVSPASQIRFFATSQNLTFLPPHKKHGINHSIRTDGNVSIVTVNVFRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LV83</accession>
    <name>A0A2X0LV83_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C013g07370 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C013g07370</name>
        <name evidence="2" type="ORF">BQ5605_C013G07370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LV83"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY15450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="82" mass="8868" checksum="E8E1BFB6C5C098EA" modified="2018-09-12" version="1">MLTPPAALAQTNKNTMSPSIPSTQSRVILINRPTGDINPDITSGKGTFKLEKDVPVEQPKEGQALIKVEWSSIDPAMRVVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LVY9</accession>
    <name>A0A2X0LVY9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C012g06714 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C012g06714</name>
        <name evidence="1" type="ORF">BQ5605_C012G06714</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY15962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LVY9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY15962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="112" mass="11717" checksum="CDF08287BA3DB35F" modified="2018-09-12" version="1">MGYTFVYAGAAVSWSSHLQSRIADSTCDAKYLVLSHTGKEASFLCQLFGELGLPSLKPVLSACRVAICTLNEGSGELGALGGKGGAGELSMLQGTCAVRVCGLEKTLKRQSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LW55</accession>
    <name>A0A2X0LW55_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C013g07359 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C013g07359</name>
        <name evidence="8" type="ORF">BQ5605_C013G07359</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0LW55"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052583">
        <property type="entry name" value="ATP-helicase/E3_Ub-Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059033">
        <property type="entry name" value="C144_05_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26021">
        <property type="entry name" value="Ferritin_C144_05"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="439"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="1309"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1622"/>
            <end position="1644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1622"/>
            <end position="1632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY15401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1722" mass="193209" checksum="FD8CAB46FFB35D51" modified="2018-09-12" version="1">MDEDFVEVIDKVELGSVAIDEMEQVNQAHQIDEVPLTSTKKQAPLLHLFNLRIELDLMRHVADHASLPTKPFSTPIVFSATRNRQAQGNMGDLSLLIAAPISTSIYSQMHFLSLNALDLQHPICVAWAQRTSGRNVTKVVLRGQASLLDALVQLEGQGLLKLESTLSLLGRSIQSSGDADHLMVQVRLTEQWYQATYATPAKQLVVHALFPAHPRTNHLESEAMDREGSVTSVDTFYAALQRAPKTQDGLIVQDQKLGNPVQETEEERAVHERRIAKGKGRAIDVDDDGLNGLSSEEEDELLTPRGLNATLMPFQSRSVRWLLRLEGVYAPPRSRTYRSRAEVLTNGDGDHMHVDPVDDEELEKDLGRIAPLPMDQLCQVARSPLWCKFRLPGVMQDLWVNRINSSIVVKDPALSRIVDDTLLAVAHPNGATASGATMCGPSLASGSGLLAEEVGLGKTVEVISLILMHRRMERNLLPPYHNPSTETDVYPSSLSLIICPPVLTGQWVKELERHAPSLRVLRYEGINKVPVNKAIEDVIRSHDIILTTYDVLRREINVARKPHQRSLRSGPQGRPKYRRSLLVQIEFLRIILDEAQMLGDTALTASETAGLLPRLFSFAVTSTPLKARLEDLQGLLTFLKIDPFGPGSSKGYLARLLEEKATFKTLWNDIGARTMKAQVEKELVIPPQERFVVPCDFSAVEAYYYNTRYSEMLESLQLDLDGTLKDPTIPWEPDASDLSRWLVSLRQLAIHPQVGIQNKRGLGHVLKSVDEVLTTMRANTVSALHTDQRVLLHARMTRAQYGMHDAEDCERFEKSLLLFDEVVRDLEPVIKEVIEQIRQAWMDRPKVAAVGLAAGSVAIPEDRQSEEEEAVDDEVAEALGLGLEDEYDSSDNDVDELAYQDHNTGLVKIRAKTDKEKLAIKTLGSLRSRLRDLLFVKHSAWFFSGNAYFNMGKLAVQEAEMYQKAEELRSSILRPWEKQVERATTRLQRRIEARVDLKVEDLEFKFAKVGPGISAQTAFEKIAVTTDIMNGWAELIWEWRAIILKLMERRVSVAGQDATGEEYAQRAEDQEKADCYLEQYTIILEQWRSAITGERSALGDQLELEIAGKQNRNRKIESQGANRAKRVKVKQFVPIKDRRVPTLEQGDTPRDILTFELTVERLQAKGDDMEAHEVVGLKRMIGRLKDTRDAEYVSAKERELLIIEIDRLTAAIKPKEKVADRLRLELGEITRAMNVRIRYFTQLQALSDAVADPDTYRRAWRGYLGEMEALREQELKVEADIRLQLASRRYLDSLNETSRLKADVNETTCVICSEPYTRGALPADMKVLTTCAHVFCAVCFARWRTRSRQCAVCKRDLSSGQWQTVHYRSKVVEQPAAKPNGEHANGTVAPKKRAIDQVTEDDDTALDTLNKIDGFNAINDLCSIPHELAQAIEAVDTYQPLSTKSDLLVKHVKYIRNENPNAKVVIFSAWQESLMILMQAFVRNGIEFVSIDSNKGKKEALVKRFVEDPHIAAFFLVSCPRPRNPVVTLLTLQAACGQQNTKSQSAGLTLTCARYVFLVEPVLHPSLEIQAVARVHRIGQTARTAVYQYYVSDSVDQRVAELRGRQGTSLFLKSSYSNSAAKESKLNQKDLSTRGTNGTKGVDESVEDQDDLIRCLFAPEHYLNLQRSLLPPLLRNDADRATPVANDAEIERMGNSAQGRAGQAALKRARMIEPLVNGGDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LW76</accession>
    <name>A0A2X0LW76_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">triacylglycerol lipase</fullName>
            <ecNumber evidence="2">3.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C019g08930</name>
        <name evidence="7" type="ORF">BQ5605_C019G08930</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="2"/>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY23372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LW76"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF1">
        <property type="entry name" value="LIPASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015802284" description="triacylglycerol lipase" evidence="6">
        <location>
            <begin position="28"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR029171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY23372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="448" mass="48817" checksum="C83E183B67A5CDFF" modified="2018-09-12" version="1">MLSRQKWSFARYLVFLALLIALPPVRAKSLTSLLGGLWPTNAGSTSDFPYPNADSFYTPPSTFADDTPGTFYQYRYAINPGHSDLTATQVLFRTVDAEGKPATTVTTILQANPPTGEKQYLVAWNMYEDAAAPQCAPSYCFNTDLGKSFCPDLLSYIQKGWIVIVTDYEGTNSGFSVGHLAGYHILDGYRAAINFLSLPPKIILGGFGYSGGALATGWAASLHNTYAPELNIKAITLGGTPTNVTSTLMHLNGGLYAGFGMTGLAGQLAVFPDLNSRFNQIATRFGHSKISAAQSHCANYALLKFAFSDIFSTRFQSLGEDLLYDPVVSKYLKKSIMGTKSSETPTKPSICMYHSNMDEVIPYEAAQKTAHAWCRRGAKINFVTLKGISGHMGTQMAYGDTALAWLDGELRGDIAPLTKCSFTSGFSLSLPIRKRSRMHTLRSHSRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LWU3</accession>
    <name>A0A2X0LWU3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C018g08723 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C018g08723</name>
        <name evidence="1" type="ORF">BQ5605_C018G08723</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY26337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LWU3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY26337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="62" mass="6566" checksum="279DC674533011DD" modified="2018-09-12" version="1">MAGTIEGISLLVLRQATSRTQYSILAGSHFLVSQVSFIIVLQSPASAFQVSSPLSSLSPWVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZ27</accession>
    <name>A0A2X0LZ27_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C017g08354 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C017g08354</name>
        <name evidence="2" type="ORF">BQ5605_C017G08354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY19859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LZ27"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY19859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="62" mass="6723" checksum="52ADFC521D6F1B8C" modified="2018-09-12" version="1">MRCQTWKASAAHHDDVQPRLTGNQGCTGADKACNRPDLIARVFEAKSGNKRHAGCFGNHSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZQ7</accession>
    <name>A0A2X0LZQ7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C002g01733 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C002g01733</name>
        <name evidence="1" type="ORF">BQ5605_C002G01733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY35157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LZQ7"/>
    <dbReference type="STRING" id="796604.A0A2X0LZQ7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015038">
        <property type="term" value="F:glutathione disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF18">
        <property type="entry name" value="GLUTAREDOXIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY35157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="124" mass="13600" checksum="9E2DF67E92BE70AC" modified="2018-09-12" version="1">MNFIRSLLNGWMPQTTEQDFAQAKSTVEDLISSAPIAIFSKSYCPHCQSLSSSAIGCCCRPIADDKQSIELDQENNGVAIQRYLAERNHVSRVTIYIKGQLIGGCSDLRSLHSGGKLEPLLKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZY6</accession>
    <name>A0A2X0LZY6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01813 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01813</name>
        <name evidence="2" type="ORF">BQ5605_C002G01813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY35891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LZY6"/>
    <dbReference type="STRING" id="796604.A0A2X0LZY6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY35891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="982" mass="110806" checksum="868E34CE59C935D0" modified="2018-09-12" version="1">MLPPCNPGCWMARGLAQLANEIDLLLGILRRAPTIVTHSNTFSDLHQTMGRHKWNRFKFRPDYFEGHPDYKPRRLRSDPQLRTNIPGTRHMVTYTARQIQQRTFNEHARGEASSPGMDWDDERHSEYGGGYERDFSPAPYFPDRTSHIPIAPDYSATAERLSLADLRQDESFEPATRGQSKQETYKQFVFNDSRLRRLERPALLRQYIAFCAGVKGHLRPLIDVDEELCQGSVASEVPPPCSCESPHYCLTLVEVPIAFCPRSSSDSPCLTYAERLAQIGLIGSTAAAPRSAFTFRLVQFLDSWWSTAPFPVDGAARGLDIFYEQTGWGRPGLSQHKFDKELRKQLQRALDEFRALTTSERELGDLVLGVAGSLSDKCPACYGSTRLNQAHHRVEVQHLVALDGNFQHSRDTSAKYDFQESTPALFIGEGELESMKEICDGGDSKKSEKACADSWKAANGGATQISRGKSDTGLVACVCRHDIALKMVNLYQSGEKRYYGLSLLQHISNQLPSNDTLGVLYDVACNLDGYMQSRSILPDLFPRLKFATSVFHAFAHQWPCQLEYNPRLIQHFGLTDGEGCERVWSQLRSLIPINRPASASHRRVNISRRIDLMNKNGVDSLGMLCHPHFHAVRLSNAQDQLGRAQTDLSDVSAIWSESDLLAQWDLQRAAQAATTAGQRRENEDKERLELFNIVQRLHHVEERLFDPMASDEAKARLQQQLRAYQQEYDRTKELAASDFQHLCNCVVKLRALHKATVQLQCCQERIDSMGRGRSGATIGQVEASKLVSVSQTHSKKVKVAIDMYNKAVGDYRNAATEQSAQILDNLPLATTIKSLVTLSPTDAFWQDGFFVHDTAPWAIDTDVQKGIKAVLLKARAEEEILRIGAEVRQLLAWLEDEDTRFVRVSQAWAEDRVPEETIEAAKKLLGTDGAGEVGTAVWHVLQRRQISFKERLDRLAERDDLSVVWLERVHPQFMNRGPRHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M093</accession>
    <name>A0A2X0M093_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g01915 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C003g01915</name>
        <name evidence="1" type="ORF">BQ5605_C003G01915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY37915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M093"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY37915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="73" mass="7923" checksum="A6AB9D0117C5D694" modified="2018-09-12" version="1">MSLLSDLVHLRTIKSWAARVQQHQLPHGPPDGAFSPGAPRAVEGYSRRNPLAKELSLQALWSCDPNCNACSNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M0J1</accession>
    <name>A0A2X0M0J1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C018g08638 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C018g08638</name>
        <name evidence="4" type="ORF">BQ5605_C018G08638</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TEL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY25543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M0J1"/>
    <dbReference type="STRING" id="796604.A0A2X0M0J1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.720">
        <property type="entry name" value="Telomere length regulation protein 2, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038528">
        <property type="entry name" value="TEL2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051970">
        <property type="entry name" value="TEL2_Regulation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019337">
        <property type="entry name" value="Telomere_length_regulation_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830:SF10">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10193">
        <property type="entry name" value="Telomere_reg-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Telomere length regulation protein conserved" evidence="3">
        <location>
            <begin position="688"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY25543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1094" mass="119190" checksum="CB74F9E8F3C25F82" modified="2018-09-12" version="1">MAIIFSTDVVSSSTKQLGATQVSVDPSSSSSSHSNSGAPTLSAPPLHTRLAAPITSTDQLLELLVPPLVQLGALPQELVSSLLSSTGSSSSVAAPPQDPAKFIKRQLALVQRVILERIWPDWEHALSTELQGSPIIARQLLSSWFIPDPNLAYTDASSLSNEIALSALQVLCSCLSTHKSSSAQTTLHTRSIHLVVQLLSEWVDQFSLERIYRIIFAKEGVSMQVREDRWERILKTLMGMPILVANRMGELTFGKGTLGQNVPQNLHLSYQTKHWARSFSDLLHTLSKTTDERSYSIISLSTTLSTLLPYPDAIPTLLNSTVYHLLPPTTFPVAADLLLSRQRLAGSWQEVILDMSDRHIARSLRLTLSEVQKRLFDVPDPSTTTIARCHAASWLLSELFGPLGPEREETWNLAFELITDRTKVWNGKEVEMARIVLGFLGTEEKTRIAALDLVMKVWCDASSIQNAGASNRIFLSTLLILLISSLPPAHPSLISLSRCTTFIQAISTHLTLLQSTVRLLGMLIAEIVSAKALPEGSGMKALSFGEEIWEGDGEGKGLCRFLRGVEKGNAEDTKGWQEVLGIAFFDDREEALKAQLDRVPTRSSPAPVVPVEKDKKLPLISVISTISSDSSSESDPSELPRYPIAPGPSLSTLAALSSPDPSLYATAIPSSSLPSTSTRKRGGRLRPPVYVAELTAYLKGLDPEGKKEEVDQEVERVEVGLREGEGLVRRKKGWGGELEENAVDLAFALMGLQDQYDIEGFEHSKRKIIIALVAACPTKVAPCIIEQYFTPSYSVAQRYTMLTTLALGARELAGLSAEIKDGSLALAQPAVIPDLATFPSKQLSPTMHKRLLEASRPTALDVLTEDVTRITLSSVREEAESTIPEASKEKLVRVRRFASAKSLHSGTSSTTSSFTLLASDYFVMPLINRFWLYLREVASMPITQQGPYAGGSGSAILLDPLILTQYLSTLALLLHAARLTPNFSDVLAPEVLHLVLALRTTGGSEDHPQVLEKEMTLLLVVFDAIVSFDGGRALMSRVEGGSNLIGESQGWATEVFERLDGGEVGLDEGKAGRAAAGVLLRIEVLTRFRGRLGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M0S6</accession>
    <name>A0A2X0M0S6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C019g08924 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C019g08924</name>
        <name evidence="3" type="ORF">BQ5605_C019G08924</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY23292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M0S6"/>
    <dbReference type="STRING" id="796604.A0A2X0M0S6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706">
        <property type="entry name" value="SLR1338 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706:SF1">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="144"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY23292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="352" mass="38882" checksum="1E83703004DA8400" modified="2018-09-12" version="1">MGLFSKLSSSSSSNKSSASHTHYAPPPGAPPPQQASSGGAQPHHHQQQAYPQPPQQHQQYQQQQQQQQQPAQQHTYAAPSQPPPQQYYQPPAAASGREDPLQGQRSALQQQSTVETSLAPGQDEPYLTHTPSSVPTTPALKKYDTVFLVDDSGSMEMFWEDQLAPALAAVIQTAIRYDDDGVDIYFFNSRHHATSRSAPELLQLFQKVWPSKSTPTASALRRVLDPYVSNLENWVVEGKPSGYPRPKPMNLIVLTDGAPDRGEAAEPVIVEIAQRLDKMRMPPFQLGIQFVQIGTDDEAAQSLRSLDDDLREKHGIRDIVDTTLFDVQGGQLNVEYLMKALLGGMNRSIDNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M0Z6</accession>
    <name>A0A2X0M0Z6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C018g08799 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C018g08799</name>
        <name evidence="8" type="ORF">BQ5605_C018G08799</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY26809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF463">
        <property type="entry name" value="REVERSE TRANSCRIPTASE TY1_COPIA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="276"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="7">
        <location>
            <begin position="542"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="779"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="298"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY26809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1426" mass="156320" checksum="D06CAF626FC4ABB1" modified="2018-09-12" version="1">MDSSPASPSAPRDPSSPESSIGEQIATLQAQLTALQASQPAAAAAAATPAVTATASKVVFPKHARLDGPKSFTNWLRQLRLALPNQTADQLAARDDAAREIIVGSITSANVSATLDAIPSDDLSAPRIFAALKARFALDDATRTLELFARLWDFRKMPASVEAYNTWLRKYMLIAQEIRDTKTSLNDVLATHVLAIVPSCLDSFRLTFTDEQQNRRNLPELTTLTDRIHIQLCSAGLSTSHLAMLATTSSCPACRAPGHRLRDCTSRAKHPPTGPCRRCHKKGHWALDCKNRGEQTRSSDNTQDDASSSAAPQPNVGYFASCVFARRQLPTDNFVVNLGATTHMIGGIAGGITAIGMGDVAFVAKTGHPITLRGVLHTPGLHVNLLSVSRLCDTDCDGQAIAHGTRVNEGLYLLDADHAKCQQLAFLSRSESTVPLLTLHRCLGHLAPSSIQKMIAAGLLDGFGAGYSDKDVEEFVCIACLGSKGHRLPFPDSELHSPERLGLVHSNVLSFPTPSLTGKRYLVTFLDDHSRKLWAYVIDHKSDVFPTFQTWLADVELETNARLRFCKSKGIRRQYSIPYTPQQNGRAKRVNLSIVEGVLALLADARLPATFWDEAAAYFVYCKNRCSHSALAKQTPEFVWNGQVTTATALHPFGCTTWLTVAPDLRSKLDPKAARVIFTGYDLASKAFRFFDHSINKIVLGRNATFLDDDFLGLPVTTPVDADDTDRQFAIPMDTPAPAVKTRTPLVRSAHMDISSSLDDSAMSAVDVAPGYTGGSLLNSTGTRSSSSPSLSPFLSPATSSAREPSLNNSDDPLDLLSSNTAVCLNLMDVHRSDNDTLETQAPAVDPIEQPSDDDSTDEINFLSRHHRAFIATENDDPTLEAIKPVKSITSDPQTWREAMSSNERDIWAQAAAAEFTAMRDNFKVFTIEPRSTLPPGATIVTSKFVWKTKRDARGDVTGRKARLVAQGNRQRDGINFSETFAPVARFSSICCLLALAAANGYHVHQADIDKAYLHGELDHDIWMTTPRGFDFPSNKVLWLRRSIYGLQQAGRIWNRHIDTSLRNLGYKATGTDHCIYSRIDDQQRPHYIALYVDDLLIVSPGLDEIERVISGLEQRYGVKRLGPAEYILGIQIRRLDDGSIALSQERYIMDVLVRFHFDTTTRGTTVPMTPGLSLTAIPGQGTERIRSWYLQAIGSLLYISLGTRPDIAFAVSYLSRFANNPGRRHWIAVKHVLRYLCATYRDELLYARGPAKVTGVVGYSDANWGACVDTSILTMGYVFYLAGAAVSWSSKRQTRVADSTTDAEYLALSHAGKEAIYLTQLLSELHVSPIAAAHIFTDNEAAAAVTHDPVRTSGTRHIRLREHFVHDMVNRGDISLSHVGTANMVADLFTKALGPKIFGMHCYALGLRTRHPRLKSTSRLRGGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M137</accession>
    <name>A0A2X0M137_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g02215 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g02215</name>
        <name evidence="2" type="ORF">BQ5605_C003G02215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M137"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY39422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="365" mass="39826" checksum="51AA0D46A8184368" modified="2018-09-12" version="1">MAGSASEKDKENQRRNGKGTGSGSGSGSGLGSAGSGSSAQASGGLKLGPSLVRAKKYIDADGMYTRKDKGNMGLRDYTCKRGQIDKIYYNWVRSVVRDALVVAGIRTPTPVQLYGPLAEINQEWSPNHDLPENYDLKDAFRLISAKTSTNTVLWGNLSPLKQREIVKYIRERAGFLAVTSGDWLYEELVIDVLANIRSAWKLAYDREVCRLAGIKGQLSKADIATLRSRHGEGPSRKSQDGVYSASDTGTSDLEEEEVLATRNRTLVPKKRGARQGAGSPQLSQETQQTSPHVGSSGQRSTPAASGVRGPGPPRNKKKKTEHNPNRSQQTNPKRDLGNGRAEEEEDEDQGQDEEEVEELERSPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M1W1</accession>
    <name>A0A2X0M1W1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01171 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01171</name>
        <name evidence="2" type="ORF">BQ5605_C002G01171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY30631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M1W1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY30631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="454" mass="50625" checksum="955DFF241CF0DD27" modified="2018-09-12" version="1">MPSLARSPSFLPFAASQTMSAEGDEYYATFNCCENVSFLEDAEHAPPLPSSFRFAPTPHQDSNPTSITTFSSPAPSQGDEFDDVIHLWSDFNITQSPLEHGLGTAPLRIDSTRRSSHARTVSASLPRCVSVPIFSRPASFHAQPARRPLSLAFPSQPRMPQRGGTIKTETVPLKVRVTNFLRVARDRTIGGISKRKPKRSLIATSRRKKETFDMVEARQARLSEPELMHRVRTPRSIRRQPAPSLDEPMWDSLKSVDSRIRPRCSTSMGEPKLAVPNLSRHRSLPTLFENFTSRSQEKSETSSFVTLRRHQSSFFSPSTAPESAKSFTSGRAPLRERNMEGFPPSRYYLPSRKMSPLPLSEVVEEVPKFDSSIGDPPLGIDWCDEDGSGDEGTAGEGTVGEEFLFDSWEERLLECYQRDSLPTPEKKKRAWARAVDLGSDDEDSTTGNSMGSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M347</accession>
    <name>A0A2X0M347_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00085 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">BQ5605_C001g00373 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C001g00373</name>
        <name evidence="2" type="synonym">BQ5605_C001g00085</name>
        <name evidence="2" type="ORF">BQ5605_C001G00085</name>
        <name evidence="3" type="ORF">BQ5605_C001G00373</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY43932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY46026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M347"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY43932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY46026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="111" mass="12742" checksum="932EF8E1689F24E7" modified="2018-09-12" version="1">MSHRSSKTAINLASRAHRRQAPEVRRPPRSIVVNRLQRPKAFLKTTRPIKKQVAKLGIPAEQYLQLSQVQESLIRIRSEPTLVDHDHWTTQEVQVNGNSSNTKDRLGDIRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M445</accession>
    <name>A0A2X0M445_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C003g02054</name>
        <name evidence="3" type="ORF">BQ5605_C003G02054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY38624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M445"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="83"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY38624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="239" mass="26815" checksum="B6C7C7E00773CF0A" modified="2018-09-12" version="1">MVLGERHEIALEPHWFRVQTERIKRNSLQHVFFECQPSSCFFTISCGRIDFVRLRIRVIGTRNSNHARKQALCNSPSRGRSSTARFGGVTIALAGDPKQCLPVILKSSPTQMLTLASWNADLWGDVEVLHLSVSSSPSLTFRPYTNRGTVQAQTNMHFLAAADRMTETEREQAQDFANWLLGVGDGSANKTEDSIALPRELFLPATTRNRSGLIRHVYPVPALELDNMSLGANIEYFRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M479</accession>
    <name>A0A2X0M479_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C003g01913 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C003g01913</name>
        <name evidence="10" type="ORF">BQ5605_C003G01913</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY37907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M479"/>
    <dbReference type="STRING" id="796604.A0A2X0M479"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010435">
        <property type="entry name" value="C5a/SBT2-like_Fn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF66">
        <property type="entry name" value="SERIN ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06280">
        <property type="entry name" value="fn3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016051875" evidence="7">
        <location>
            <begin position="20"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="8">
        <location>
            <begin position="189"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="C5a peptidase/Subtilisin-like protease SBT2-like Fn3-like" evidence="9">
        <location>
            <begin position="650"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY37907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="982" mass="105173" checksum="E8B04C68F735C52F" modified="2018-09-12" version="1">MLVGKVSLVILWTATMALASPSRRGNHKSTTGKRSSFGSGRYLVKLSTQTDMKGSKVPVEQHRQDCNDQIKNLSSDFFGAIKVHNTFNFAYQCSMSVEAMEGFSPIDLADYLGVTGVDVIKVVVHGRGLSFPMPPPVSKLQPKVGFATPWRKNHHPLLLSPSVYRNNSFAPHVESEVHLMHNLGLLGDSNVSVCLVDTGGSEANGVDYTNRRLGEGFGKGFKIVLGHDFVGNDGKHPGPSPYTNCTDHGTHVTGIVGANFDPDFKFSGAAPEVTLGHYRAFACTGQSTEDTIAAALLRAHADGCKVITLSLGGPSAWEDGLVADAASHVTNQGSLVVSSAGNFGTQGLFYGDVPGELPEVLGTAATDLREYPVGYLLDFVDHSFQPIPYFAVYPVKINETLDVCYIPPSITDDPKCNLSTIVLPKGDLKNSLLVLELGQCPHSLVAKWAVANKLRVAMVSFKPEDAQSPLNYYSNHFARGIDYFLIVPHSWVETLIRYYTASRGKLQVSFAAGKRAPVEALANHESGGNMAFYSSYGPTATLEGFGNTLAAPGTNILSTVTVAQGGVGVMSGTSMACPLAAGIAALLFSHRKADNLTPRQVKSLMATTAQPVRISQKPKDAFATVVQQGAGIVSAYRAYIAKTLIEPHSIALGDLEHFKNSHSITLKNTNKFAVTYTLSSTSSQTVTTYDKSASIDINPSGIPRPGIAGAATVAFTPRSLTIPPGQSATFTATFTLPNFSKIDFFRVPVVSGWLLIDSAGDPVPTYRIAYAGVAAGLQIMPVLDSTDVASQSYGIKGLRHPFIMVGNSLDPDALPSTAADVLSDPNKVTSVSRKDGIFVFLRFAMATPYVQVDLVDANTTFIPTIPSNNNLHLAENNSLTGDLRKRPHNPPLFDSVSIVGTAATANELTRDPTDFSHGSGADTSFINFNGMVAVKHPDDPATTSVDKGRPYRLLIRARRMNSNPEFSASYDSWLSPPFQFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M564</accession>
    <name>A0A2X0M564_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C003g02162 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C003g02162</name>
        <name evidence="3" type="ORF">BQ5605_C003G02162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M564"/>
    <dbReference type="STRING" id="796604.A0A2X0M564"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102:SF2">
        <property type="entry name" value="GAF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102">
        <property type="entry name" value="SLR1143 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="237"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="417"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="533"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY39173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="696" mass="75536" checksum="5362C12F5A6AD12E" modified="2018-09-12" version="1">MQDMRSRQERSSSKKKSGGELKSIRRMFSSFGLQNSPAKNSRIATRDISEPFTATYAEGTFSLQQKKRVTIAEQVIYASRKIVHVIRRKLSSKTPANELPKTWEEYSKAYAKYEIDIEDPPLPPVREATDAADPTPFEAKSYMAPKPYNESERQAVVDKLDLFGTKNKQANASTSTLAISMPASTSTSVTSSLPVSAGPDSLLRRHSYGNTSVTSAATSFMPPDIGSECAAAVTSLQNYPAFRDIVQKCQKLFGVRVGMLTVLDEEQQLFLATGGLPEAVEQGGALPRAVTFCSHAILNEERGMVVLDSLNDWSFANSLPTSALGARFYAGVPLLAPTFGDPDAPNVAIGTLCAVDDRPRADFSENERTELQKLAVEASTHIETWVNERMGMKLKRLESSFARSTATMPAPAEAENPVETAPEPEAGEPAVVRQVETESESEIAFEDALAEPSMPVEQAHFENSAPNPAPAEPAHLAAPARLVARPPRAEHRPRPTAVFQPSPQVSLPLTPPDSLKGSRNHGYTQAHARKGSDSSSSMSSFTSDRPVARRPSGFNTLSLAVTSKDPVTAVPKDLQKVFDQATRMLALALDLVYLVSLDVAALNSGTNTHSALRVLWPAVLKPRYSPEEAGPGYSGGILIPVLEVRLTGYVLSGYSKDATRNFEQKDLTYFVRFSEQLETYVTKLGRVSGSQIAVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M582</accession>
    <name>A0A2X0M582_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g02273 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g02273</name>
        <name evidence="2" type="ORF">BQ5605_C003G02273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M582"/>
    <dbReference type="STRING" id="796604.A0A2X0M582"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="928"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY39764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="950" mass="105415" checksum="A753A850CDCDE593" modified="2018-09-12" version="1">MSTEVPAPHARASARTVSPTLNSSHFHRSPSVQISNSSAAGSSWPNAPSSTSIAPGASNGLHIDSVSPTTTTIETLPGRLAGTSDVHQLQHHQQHHQHSSTSVNDPHSSSHAQSHAPPHTRSNPTTADHEPASSFQKWGQRINKVWSNVAGQNEQDVNARRFSTSTSAMASTTTAHLRTPTLGRPTIADQLRLSSARSRRSIPRDPSSSRHWILSRTYDRIKPLLATLYVTDADSDSSAASTWIPFFTPGSGYPLGFSRRRSSFGSVSHVPPLSRSGWLIVGVLFLLGLREIVGRSSFSGDRRRNVKVSGRSPYSVIHDLSPAEKMSSYFDSPSSSATPAILAGQDRIWKREHITTTDDRFDDATGPRGDTTAIVLHWKRTENVIVIVSHLCRYTFFDSITVWNNNPAVQLQRSDFDSAKCPSSKLRIYNSPRNQLFVARYLACAQSRTAYCYFQDDDWLVWPLRALYSQFSRDPEGPVVVHTNPQVASLYTLEWCFYAAPPAKGNDDFMESKPPAQIHTCFAWMGTGAFVSKSRVIHYLANLTDVAYPSVELAHADNSFTTFLNQPPYVLSSELTQLPQPFGHSDGKGIARNKAYIHQGIQHLYKYLDIPTTPSKPGEKFKLPAKPLLLDTHAHHHTSRSSKLPPHPYAHHVRSPCHTDTCNFMTSVALLPPPDSVPYPGPEKVGDLETWENHLGWTARGWIEGNELFREEETFANKWAYAHAVDGSDETAFRSPDVIKMDDYVGLALLTPAELTWTPALTFVFVLEHWAVISKSVVFEVSRDGYKWVEPLSPPSAPSCQGIATQSSLPDHSFPPSTYLSSRGQAILEAEVALFSGNKVMTWFHRRRRRSEPLKRCRIRIGTKFEGGNSEEGWRFVRMRSLGELEIGWGVYEMGRPPQLVVAQHLAMAPQRHQKTGTASIAISDWPGPYDTSTTTQSAARAYAPKGLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M8K5</accession>
    <name>A0A2X0M8K5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C004g02740 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C004g02740</name>
        <name evidence="2" type="ORF">BQ5605_C004G02740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY67065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M8K5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="441"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY67065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="665" mass="72161" checksum="FD148B60392164FD" modified="2018-09-12" version="1">MAMPAVDLRPPPSANSEASLLQPEPQLRSPASPRPAPRPRPAMPTVSAFASALFDDNGNANLAESGSLPRLPEMSPTTGAVSRISETSHAFALEPTYTPGTEPSSSRWSGPRMRTLETPSLRPLHLDARPLRSLSSQIASSTDADETIDPRVARSSSMHPSGRSSDGPAIYPSISGNNVFTNEEPNAIPSSVTLLRRAPTPALPMATTSTGDELLFNLGNTAATPSTHYDSSELLMSTVTPWREFSAFRSSVHSAREAVEPLTTIGRPANTSDPFSARLAGHNETGTSTMDTSRLSDTQRVLRGAQQALRTAVAFAERLEQVTQSISSADQHGYIGGPELPTTRTDRWTPARRLSDGAPTTTTSLRSSSIMAPSAMLSLQRSIVQLRVASLRIDILLQEFPDFVRAAAHDEASPSPSDAFNVGAEVSPEEHRARFYHHYNTSPSTSSTSVSSLAPTGDTRTLASSSSDNIDSRLELARSRLRHAQMTLDSMSRIRDQQDRYVQQQMQPGSSSGDAPTLMPASASQEFPSWEEARRARPEWQFVPTTSTLAQEQNPPRTATEIAAITPGPAPAPMNPSLLTRWRMSSQRSPLTRGTQASNTGRATRRAFPIKLDRNGVEIQDESGDEQSDQEDDVGPRQFIGGLFGGREERRPPLRRKWSRELCGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MA02</accession>
    <name>A0A2X0MA02_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C005g03175 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C005g03175</name>
        <name evidence="8" type="ORF">BQ5605_C005G03175</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY72470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MA02"/>
    <dbReference type="STRING" id="796604.A0A2X0MA02"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000034">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="255"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY72470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="502" mass="54744" checksum="E251EB5423643A5B" modified="2018-09-12" version="1">MSAPSETPAASSSTAAEPTAAAAAAAQAPAPAPEPSPKDKAIEAYRKKLKEHETLTENLKKSRSSPAHHSRAASPTPETEALTTTTAVDVDAVRASLKDLDRDFDKSEDDIKALQSVGQIVGEVLKQLDEERCGFESGEAIHQHTVRETHASTSSSTVIVKASSGPRYVVGCRSAVPKHKLKNGVRVSLDMTTLTIMRILPREVDPLVYNMSMEDPGEVTFAGIGGLGDQIRELREVIELPLMNPELFMRVGIKPPKGVLLYGPPGTGKTLLARAVAATLSTNFLKVVSSAIVDKYIGESARLIREMFGYAREHEPCIIFMDEVDAIGGRRFSEGTSADREIQRTLMELLNQLDGFDYLGKTKVIFATNRPDTLDPALLRPGRIDRKIEIPLPNEVARMEILKIHAGPIRKTGEIGASVMSELDAVECATDDANLTIKIDYEAIVKLSEGFNGADLRNVCTEAGMFAIRDDRDYCIQDDFMKGARKLQEAKKHESSSDYEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MA89</accession>
    <name>A0A2X0MA89_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C007g04536 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C007g04536</name>
        <name evidence="8" type="ORF">BQ5605_C007G04536</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY61218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MA89"/>
    <dbReference type="STRING" id="796604.A0A2X0MA89"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038753">
        <property type="entry name" value="NFKBIL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263">
        <property type="entry name" value="I-KAPPA-B-LIKE PROTEIN IKBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263:SF1">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="181"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY61218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="343" mass="40144" checksum="7366DEFEA8FD5B0F" modified="2018-09-12" version="1">MKDSSLSSTEQAVRDATRRASKQSHKRRHHHRSSTQGAAPPRDRSESLTPPRSRPSTSKHTLEHDLPDVGDDFDQSSLPPSQAYKRSRSYDQDDDDEERRFQDKLRSAEQEDQGVGYYEQLLYERELVRNAASFHYGSSVRAAMGQPEAQKGATLIMDEEEYAEYIRAGMWRIQNKEEILRRERLDKAKKAQKEKDRIEREAFQKKEKERIRKLEERTIKKDQQMEKDQREAYAAKWSKITASSTETNLRFSDIPWPIFPHVPFPPLSWPSTTDITPLQVNRFLLSHIKDKDVRKSTLRSAVLAYHPDRFYRLTARIKDEDTRARATELGLRISQTINDMLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MAI2</accession>
    <name>A0A2X0MAI2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g04234 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g04234</name>
        <name evidence="1" type="ORF">BQ5605_C006G04234</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY57187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MAI2"/>
    <dbReference type="STRING" id="796604.A0A2X0MAI2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY57187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="156" mass="17708" checksum="0FC41E6ECD8517AC" modified="2018-09-12" version="1">MVSLGFASCARSAELTVPSTIRFRDPAKLPQRSTVKMDSNGFSVHLPYHKADRRWQGLFLYFTPCTTDPAFLRILHRYLQARDSRNKSSDLLFLTRGGLPPTRTWFIGRLPGGATHYALQGLSADIIKRLGRWRSSAWEEYVRVSPQLQQALLNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MBR2</accession>
    <name>A0A2X0MBR2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="28">BQ5605_C005g03722 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="28" type="primary">BQ5605_C005g03722</name>
        <name evidence="28" type="ORF">BQ5605_C005G03722</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
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        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
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        <property type="entry name" value="RVT_2"/>
    </dbReference>
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        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
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        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="20" id="KW-0233">DNA recombination</keyword>
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    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
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    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="19" id="KW-0917">Virion maturation</keyword>
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</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MCZ5</accession>
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                <person name="Wedrychowicz H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <begin position="1"/>
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</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
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            <begin position="944"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY67049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1153" mass="123361" checksum="54F6B60C1D435DD3" modified="2018-09-12" version="1">MSETNGGGRVVVGGGQALNGGGKQQAIDVYDDPAIPLDPMLTADLSTAFSLASVVHPCQQTSPGSPASASSASRESLVSITKSHLLRVGALGIPLSDDEDFADDDAELHSRPSTRSDLGSVLVNPASPGLPPRVTPDHGHDGTMRLQEVNHLTPGSAYSGKQAMSAIGKEQERLSHAGANSALSEGSFRDIVDDLTIENRKLKGRLRRFEASSVPASMEQDRLFEVRFFDGFPPSRRQEIESFLTHYVQQIQSEDGEGFQGPPPMTSGAKPSRAPRADQESATLGTDTTSSIGVTLRSLRSSEKEELSKRLNAGGPEEGSGSGSGSGSADRLSRESGPPPLSTENVERVKSESVIAGPPSLPAKVREGSHERTMVEAPQGEPSAEAQDVVHPYDGEQNWLAAPSFSGIEPQSASGTGTGMRISNPQRREARNRPVAKIPFPSISRRQSHSAIAAANAAEEVKGESSAEESEESPPPHNVGTAGSDDSGSDEMTTSLTTAEPLAKIVVELVERLFAGAWSSSPVDDPLLNPLLSEPSPLPPTSSSNTRYLRTMLDSDETKRGGGWVYLNLILTMAGVHRLNLSIDFLRWSLKRRSHRVEVSKDGSKVRWRGEARKRNEVESAIARAEGVDANDATMDDGAVEAVEQRRQTNNLAVSTSLRAPASDSNIYLPREADTASSDSRLRRVAATEDDMQSGSVPPTLSSIKNSNTNSKNSNSTGATSIPTGGSGSGRSKNDSNSLRDESGRSTRSGVSRASISGTATNSLTNSQPSDALRKALQKELLDARGVPDYTLHDGTISVAPLGGDDDSTGTDTEDITRRNPSVAPYRPMFAKRQFEDDESDYFARSDDESSSGHGEDSILHSTEGGAHSTEARGRAPARKRRRRHGALDGGLVFFRSDVFCSDLAGNAHVRHRLERSPSADSDAVDRARISRSDGEDDGDVHSPNASIFVSTPSPPSEASGQVVELSDTTWKALVWPAWETETFSQMDVESETSGLPSLSLSGMTNVVPMDHFTIRIKSELVCDPSVTPRPQLRHARAVIASLASLLPSRPTSSAPPKPLHTTRVLEERIATHLPSSQVRFPRFRMRRQGSDSDGDSSGEEVFWRRALVEPPADYLLSLGIPFHGWAPETRHDGGSEAVASSLDPDNEPISLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MDI0</accession>
    <name>A0A2X0MDI0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein ARV</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C009g05647</name>
        <name evidence="12" type="ORF">BQ5605_C009G05647</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Regulates also the sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Golgi apparatus membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ARV1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY83642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MDI0"/>
    <dbReference type="STRING" id="796604.A0A2X0MDI0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097036">
        <property type="term" value="P:regulation of plasma membrane sterol distribution"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007290">
        <property type="entry name" value="Arv1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467">
        <property type="entry name" value="ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467:SF0">
        <property type="entry name" value="PROTEIN ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04161">
        <property type="entry name" value="Arv1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY83642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="352" mass="38227" checksum="1C78D141A116D9AD" modified="2018-09-12" version="1">MGSTTHVSAQDKGKGKARTTSTSSSSSSSSSSSSSSSSSPSSCSSPSLERGSYVCVHCNRRVLSLYVTYSDPSNTSLLQCASCGHLLDVYMTLAFPVLLVDLLLSKPRVYRHLLTNRGSNDPKERECQRTESTFRIGAIVVGLDALIRCTNVGPPESLHPVSLYLRVLGYCLFETFSLYACIALSAVFFRTFSRTSKSAPLSRLRLLPLTLFYTSLPTLFLLFIVSLIWREEYSVPSSPLSPAAHLDLPTLLAPIFIPLLGGLPSGDDGFVKRVSWLSRENLKSGVSTFGNVRGWANEALLRKGVGGSSAVVGVAVRFSVLFNASQSRTVLILVVAWLLHLFTLHLMDPYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0ME70</accession>
    <name>A0A2X0ME70_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BQ5605_C005g03511 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C005g03511</name>
        <name evidence="11" type="ORF">BQ5605_C005G03511</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY76725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0ME70"/>
    <dbReference type="STRING" id="796604.A0A2X0ME70"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000029">
        <property type="entry name" value="GLI family zinc finger 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000275">
        <property type="entry name" value="zinc finger protein 90 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226:SF416">
        <property type="entry name" value="FI01424P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226">
        <property type="entry name" value="ZINC FINGER AND SCAN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="288"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="317"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="347"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="47"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="114"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="370"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="421"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="630"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="430"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="455"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY76725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="806" mass="86701" checksum="680F08D325920A0B" modified="2018-09-12" version="1">MSRAEGAVSDGNAPVDAADAAAAKADVARPVSKRCVADLPSNGVNFFERVDQMAPPPRSSVHGDATRDQPSSPPFASMKVVDCAGADVVFEQARETAGTSTLNHFTPSLQAMEANTEAHPGPENMMCVDSGAERRSSSANGAASSPTPSASSSRLTSLDDGSVPSPRLAAYDISKPPGPTTTSEQDAFPGEAEPQAPEQRRGMQLRSFQQFQVPNPPDLPQHPSHADWIAANHDRSTTSSIKGDVPDKLFECDDCGKAFARKSDLLRHSHIHSNIRQVSAREIALRAFMLGARCEKDFIQRSALTVHFRVHTGERPHVCTHLACGKAFSDSSSLARHRRTHTGAKPFQCEVPECGKKFCRKITLTKHVRREHVPGGRLPRYRGATTRRKLRSGPYSEHQNFEETTNTIQNAERLLGWASRSATHGEPQDHGGGSLGRGDSGIGSGAHTTQHPKGRSTEARDQGRSRESAYAFDGSSRRSQGLPKFPDQCLSPYDPPSVGTSRDDSLSHQLQSSAAVATSCAIKPVHPQLASLQAFYMESLGAYPQQAQASISYEARTAVSYPSTNRGTSSSSSFASSCDTMSGAIQDRQDCHEPQLQWAQPPQNLRYHGDVDGSEYANFNAALPMYPSTSSLPHIPNPEVSRGPTDSFEAGSDPVPNFRRYPSTWAPPGNAKAQHQPDPRSSTHFYGDNAAGHTPVWPTLGSSTDESRNEVAAQSNVLDDHPNPCYSLNRGLWAANASARRVSQIPLPEAEFSLVMDDGRLGGELRQENAPPAGAVYATSSVMGGVSIDDRANLANCGFTRGRVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MF58</accession>
    <name>A0A2X0MF58_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphingolipid C(9)-methyltransferase</fullName>
            <ecNumber evidence="14">2.1.1.317</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BQ5605_C037g11596</name>
        <name evidence="16" type="ORF">BQ5605_C037G11596</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CFA/CMAS family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.317" evidence="14"/>
    <dbReference type="EMBL" id="FQNC01000062">
        <property type="protein sequence ID" value="SGY93562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MF58"/>
    <dbReference type="STRING" id="796604.A0A2X0MF58"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052290">
        <property type="entry name" value="Sphingo_C9-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197:SF1">
        <property type="entry name" value="SPHINGOLIPID C9-METHYLTRANSFERASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197">
        <property type="entry name" value="SYNTHASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SGY93562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="540" mass="61145" checksum="22C94344336128F1" modified="2018-09-12" version="1">MSVPLFWPAPSFDANAGFKITSRPAIANAPFPIESNGSFSNLTLAAIVLFAPYLVARWVPLLPTKWSYYLLFLPVGLASVLGYWMLMSRIGGKKRDYGTRLPGKPLEYYVEIKDAKLAQKYSGGRAKIPVQTFYDAYFAGKIDLKGDMLELLEQRHDWASFEFTWDLLKYVLTVLIPDVVWHSPSQDEEQVRDHYDRGDDFYSWFLGPRMIYTSGVINDIDRKETLEELQDNKLALVCHKLELKPTDTLLDIGCGWGTLVTYAAKNFGCDATGVTLGKNQTKFGNKRIADNGCHASRARILCKDYREIGVDKKFSKIVSLEMAEHVGIRNYNSFLRQVYNLLEDDGILVFQVAGIRPHWQYEDLIWGLFMNKYVFPGADASCALNWVIGRLEGAGFEIKSVDVLGVHYSATLHRWYENWMQNRDAVTAKYGDRWYRIWLYFLASAVITSRQGGASVFQISAHKNLNSYHRVEVRTISPGSDFALSPRESPPSPDIRAGWLTISRLCHVATASTHVTPESQAIPSHTSLFFKPAKEPSLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MFS0</accession>
    <name>A0A2X0MFS0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C036g11558 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C036g11558</name>
        <name evidence="2" type="ORF">BQ5605_C036G11558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000063">
        <property type="protein sequence ID" value="SGY96313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MFS0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="357"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY96313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="487" mass="51582" checksum="D2C5FDF961EA8E28" modified="2018-09-12" version="1">MPDPPGPPPHPPNAPWAGDVLRDESLNTETRETVTGGTVNPPAWSAQASQARLDHEKSMHKAFKALGIVPSSKSTRRLMVLLYDPSSPPSQAPALARAAQRAVQNDAMPASNVIRVSMDGTGSPRGPVQIALRKHFGLAETPFMFARPEGAKLDPEVEKLFSKCVKLNPIVTKATKRFPIARHMYELVFESDQACLEAAAAGPFPYHGKEMVTKLPSVSPLNHIVQVRFTLPSSSSAIPASVLRKSLDAALTSSFGHAGCTQGYTLMQLQRGLAFDPNSDPMAMTKDGFHCAYLRLHADLFQGSTETQKAALNTALSQEIEILGAKYGLRHEFETHYCAVCDCAGHQWGACRKPVSTPATAAPVPGASTSTTGFRVAGKNGKHGGPAALNSRASGTNMIQLGPRANPAGSATGNKDDANDGDGDDDDDDGESVASTEPEGGDTGKETLTRATTGPTKETQTTTAAPVSTPTSPLSKGYYCFLPLRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MGA4</accession>
    <name>A0A2X0MGA4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="22">BQ5605_C017g08379 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">BQ5605_C017g08379</name>
        <name evidence="22" type="ORF">BQ5605_C017G08379</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY19913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MGA4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0229">DNA integration</keyword>
    <keyword evidence="18" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="16" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="15" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="16" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="17" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="21">
        <location>
            <begin position="669"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="SGY19913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="788" mass="86765" checksum="91F4A6CDE71D6CCB" modified="2018-09-12" version="1">MRISRKAAIGYLIRSARLFSEAWRCAPTHYGYYHMQLTDGWITRSSVSYLVASVLPQGTDPHAEKTQRISKMATPTADHVSLMGDLYGKVDATNWGVARERLQNVLKGEGRLKHVTGVLDVGPEPLQSEFTRLEGDNRVDDVATYRNQLRLYRQDVGALDQALAQARNTLIVCLGESTFARVKANATHDLWAALDKDLGRASDDFMRSAKLDALFLCEPFVDGEALDPWLANFNRLFEDLVAAHVSRDKAYQCARIDGTSFTQSDFDKWVPPPTLSEGVRMDLLKARMPRNLVTVIDSIGTLPSLEQVEGAIRRAALSSSRQIEPIAEALAARVQSWSQPASGRPSGPSAPPFLQASRVPGLKERWPHGISHAGRLKLGRMQCRRCYEQGHLGDECTVPSAEVSRRRIAVLAKHNITIGAADVMALVAVDRAPEAQLEDKAYKGYFVVGVPIGDDDTALYLSDIPRYLLDSGATRHMTTRRDLLIDFKPFTTERVRVVGAFNSSAMATGTGTLRFGVNEASIELHDVLLVPGLSAELVSLAGLMKDGYELSNECDTAGKHTGIAISSATSRLSFTLNRNHYVLQASSHPPPRADHLALTATTLPTDVVLWHQRLGHPSWGRLVELVRPGQIPLDVAAVTPDQIRLLDQYDACCAGKTISSPNREPASHPADAPFSRVFADVWGPSPVPALSGARCLCGITDEFSRSRWARSIRLKSDSSAILQDFVAMSKTQYGGQGVTTLRMDRGGEFVNHRLRDWLAARGIFHKLSTVQVIWIATSFWCQPDIREC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MH30</accession>
    <name>A0A2X0MH30_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C008g05191 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C008g05191</name>
        <name evidence="7" type="ORF">BQ5605_C008G05191</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MH30"/>
    <dbReference type="STRING" id="796604.A0A2X0MH30"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13532">
        <property type="entry name" value="PBP2_PDT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21022">
        <property type="entry name" value="PREPHENATE DEHYDRATASE P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21022:SF19">
        <property type="entry name" value="PREPHENATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate dehydratase" evidence="6">
        <location>
            <begin position="9"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY79665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="227" mass="24682" checksum="B36D0109437DE38E" modified="2018-09-12" version="1">MTLTSTAPRIAFLGPLGTYSHQATTDFFGNDCKLAPQERIIDVFSNVASTSASFGVVPIENSSIGIVHETMQALRTTELSVRGMIGLKVGHALLSRPFANDEDSKSRNLSGDEEKRKRYKRVYSHEQGIGQCVSYLQTNYPRAQIIPVNSTALAAQKVLQDPPEESLAICSIKCAEVYGLRVVDRDIQDGGSANTTRFIVLSLGSTPLPEPYPIAPHLRGYTGDAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHF8</accession>
    <name>A0A2X0MHF8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C016g08257 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C016g08257</name>
        <name evidence="1" type="ORF">BQ5605_C016G08257</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY21617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHF8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY21617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="91" mass="10580" checksum="D63CA498D326705C" modified="2018-09-12" version="1">MVEGTTLRRGKHAKQVVWEAESHMSGRFDGKWNLDERWNLGEGRRSGLADAETALANWDALDRELPMTSRHVVCLVLECSLSRRRFLFFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHR5</accession>
    <name>A0A2X0MHR5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C019g08869 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C019g08869</name>
        <name evidence="1" type="ORF">BQ5605_C019G08869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY22896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHR5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY22896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="50" mass="5403" checksum="94B7F4864076E246" modified="2018-09-12" version="1">MIIDDTRGESSGCWNGLVQQKTISSVSTMGANWVEAVIASESEARDSWAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHU5</accession>
    <name>A0A2X0MHU5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C130g13363 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C130g13363</name>
        <name evidence="25" type="ORF">BQ5605_C130G13363</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000058">
        <property type="protein sequence ID" value="SGY89164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="456"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1317"/>
            <end position="1383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGY89164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1383" mass="152550" checksum="01F1393B52B01ECD" modified="2018-09-12" version="1">MDDTLPPLRRCCRHHPPRFPKHARLDGPKTFANWTRQLRLCLADDIRSYVLDGIVPLLANSIDSAEVSAVLDAIPTADLTAPKIYLTLKSRYAPDDATRTLELFSRLWSFRPMPGTVGEFDGWIMEFKAIAQEIIDTKTTINDVLATLLLAIAHPSLESFKASFTDEQRTQRSLPAIDSLADRMRVQLRSTNCLACHSPSHRVAECPVRAKHPPPGPCRSCKQNHWSFDCKKALENGKKADTANSTANSQHHVGCIATGFLARRRQLRTNSFVVDSGATSHMVSDKSLFTTYRHIAPTKIGGIAGGINAIGTGNIAFVAASGHPITLTGVLHTPGLFVNLLSVSRLCDTDDVRVAFTKHGIDIDKNGHNIAEGTRLDEGLYLLDADHSKCQHIALLSRSQSSVPLLTLHRCLGHLAPSSIQKMVAAGLLEGLRAGYSDEEVEKFVCNACLSAKGHRLPFPDSDSHSSERLGLVHSDVLSLPERSLTGKRYLVTFLDDYSRKLWAYAIGHKSEVFSVFKTWLAEVELETGATLKVLRTDNGGEYCSRAFTDFCKVRGTRRQYSIPRTPQQNGRAERVNRSIVEGILALLADAHLPKTFWEEAAAYFVYCKNLVQHSALDKATPNSVWQGGRTTASALHPFGCAAWLTVAPELRSKLDPKAVRVLFTGYDLASKAFRFYDTTTKKVTLGRNATFVDTEFPGLCGDSAEPDDDTHFASAPFADPQTTVKSWTPLVSTYREPASAEESPDELDLIGRHSRDESPDEIDFLTRHHRAFIATDDDTSDTEAIEPVKSITSDPQTWREAMSGDKREVWAKAAADEFNSMRDNFKVFTIDDRSTVPAGATIVSSKFVWKTKRNALGEITGHKARLVAQGNRQRDGIDFTETFAPVARFSSIRSLLALAATNGLHVHQADIDKAYLHGDLDHDIWMTAPRGFDLPGDKVLRLRHSIYGLKQAGRIWNRHIDASLRDLGYTATGTDHCVYSRLDDRQHPHYIALYVDDLLMISPDLAEIERVISGLEQRYGVKRLGPAEYILGIQIRRLDDGSIALSQERYIMDVLARFHFDTTTRGTTVPMTPGLSLTAIPGQATERIRSWYLQAIGSLLYISLGTRPDIAFAVSYLARFANNPGHRHWIAVKHIFRYLRATYRDELVYARGEARITGVVGYSDANWGACVDTSISTMGYVFYIAGSAVSWSSKRQSRVADSTTDAEYLALSHAGKEGIYLSQLLEELHVQPVAPAHIFTDNEAAAAVARDPVRVTGTRHIRLREHFVRDMVNRGDISLSHVGTSDMVADIFTKALGPKVFSTHCYALGLRTRHPRLGSASHSRGGGCKESTLSSTEAPRSSRAPASPPPCGGDLGARDCLSEQAPADSGARPLGRPLEVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHV8</accession>
    <name>A0A2X0MHV8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C131g13375 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C131g13375</name>
        <name evidence="3" type="ORF">BQ5605_C131G13375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000059">
        <property type="protein sequence ID" value="SGY89344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHV8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010286">
        <property type="entry name" value="METTL16/RlmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393:SF0">
        <property type="entry name" value="RNA N6-ADENOSINE-METHYLTRANSFERASE METTL16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05971">
        <property type="entry name" value="Methyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY89344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="230" mass="25120" checksum="E6375D94FEBBA576" modified="2018-09-12" version="1">MCNPPFYESEVEIRALATEKDGQPSAVCTGASNEMVTKGGEIEFVGRMIEESVRLGSHIRLSQLIAKLKTHKISNYIVHALSSGRTTRHILVWSLGAWRIPQSLAQITPFTTKFSPPVNSVTFRAPSEMDAPTLYNLVCTILYSLDGVKTSHSAPGVIQMRAACNSWSRSARRMARTPLRQVSPAKTPLEQVAIRSEATFTALQDDGEDAGCSLRGEWTQGLGASQSRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIC7</accession>
    <name>A0A2X0MIC7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C030g10879 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C030g10879</name>
        <name evidence="2" type="ORF">BQ5605_C030G10879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000069">
        <property type="protein sequence ID" value="SGZ09515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIC7"/>
    <dbReference type="STRING" id="796604.A0A2X0MIC7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="479"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ09515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="763" mass="82305" checksum="4758F9F1725A95CB" modified="2018-09-12" version="1">MSATTLNLPMRHLFSCTPHTWFEPPPPGNAPDYSTAPRLQANAGTAFDCAARSGGLRWGDYSSPGDRIVDSFLSLLDLHPSLLELFEAKIAVIEATSLTSDGCMPRITEEEVRDAFTSIFAGGLRGATRELLDHYASISEANFTSSTSGYWVKLRSVQGLSYRTRGDAILEIGRGVEDSAVVVSSIAIEFKRGPVHHTAAKGPPPTGSNSAIPVLDHASPVPLQNLETQVSVGPDAIATKAIIQCASQGCRFFLLFSVPFFQIGELVEHQPSDAARASDAAASTASASTSTAPMPGTPHSSTPTPPTTTEASAPPAVRRQYSLLLQELVRWVERYPGTSLQPAETLGVDLPARSFIVSFIALAFTAVMKVPEPGKASVKELLDAIPNTSNQSRPRADSDSDREDPSYEPANKAPKTSAIGPGTRSSRRLAGDPPLTQAKGSNRPVTPPVSEEAGSDLSSGALTPEALCFSSPPASTDRSPTTSPASGSVPSSKSITIAHDRNFVIQASLSNAHWSMMSYTGTSRVNLVEIDFDIVSLDRSDSPLSSLLSSNPSPATDFIRSLHLSDAIVQWLTEDPKDELEDDRIPLELLGYFEATADLRLEKQVGTGSTADGYLANVVRVNPRWSSPANREVPLVGHPAPNTRYFLKLVTCNHVGSVVRETLFYQHVFPHLPDGLQKHLPQYHGTYRGINGNGYAMVLENVGTHMNYSEFYERSGQWQEIEKAFVELGIVHNDIRQGNVLVRPDGGGFCFVDWGRSYLKLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIP6</accession>
    <name>A0A2X0MIP6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="6">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C011g06587</name>
        <name evidence="10" type="ORF">BQ5605_C011G06587</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="6">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="6"/>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIP6"/>
    <dbReference type="STRING" id="796604.A0A2X0MIP6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17956">
        <property type="entry name" value="DEADc_DDX51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="575"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="845"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="40"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="248"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="359"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="469"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="189"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="263"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="312"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="397"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY12726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1038" mass="114373" checksum="B815BC46015FD3F6" modified="2018-09-12" version="1">MFNIKRFDPNSSTVPNGIPTVLPLEERALDDVALKIQQRKNKRKALLVEDDEEDPILDPLASTSSLISASSLNTKGGRGLESKGMDEDGKGEWKPAPGESPAEREKSLKREKRAAKFGFDPYARSQPIETNQDPTLNYQAPSTTPILPIDTTAITGEWKPAPGESPAEREKRIKREKRAAKLGLPNPSLGESNSSHLGQSINSHFVPPPSSSAFPKSYHTEEGAPQTEGAGLSTIHPDRLAAPALARELKVKQPQATTPARLRYLKKKKLRAKGRKRRMASGASKKDGSASTVGGTSVAGTEVGSDEEEGEENVKEDGKTMERKMEKDEEKLRIIAEKKAERKAKRDAKKAEIRKLKAEGGVVPPTKPRVIAAKPSLPMASPVKTGSVTLNAVPEVVEDKSAEPTEEELEKRKEKEARLTRKEAKRQKRATRHAVEEPTQGEDVELEGPPTLIPTAHKVELDVPITVSDKPIPMEADPVPQRAVEEEPSPLLRLPSATRPAPPSKKTLSELNVHESVRSKRIVDPDRKVRFDDETLGLAERGRKRLAEMGLTEAFAVQTEVLPLLLPPGEPNSLYSPFRPPRDVCVSAPTGSGKTLSYVIPIVETLAPRIVTCLRALIVLPTRDLVGQVRETFEAFSKGLGLKIGTATGQHSFTHEQTSLVGEKASTISLQGGSSSVDILIVTPGRLMDHLRSTPGFSLQHLRYLVVDEADRLLTQSFNEWSPAMLAALHPTPSTTRASIERCPRSDRADVQAPAWWDAETGRTSSELDVRSVSSCQKLLFSATLSRDPAKIDSLQLHRPLYISVEDALDPHAEDEAIDQELKFTFPASLKEQMIISPSTHKPLYLLHLLHGIKVEVALCFTKSVEAANRLAKLVEFFEQARKSRGIGEEEGEEKLPVVKPYSSDLAPVERMKLLTAFKKGDIQMLICSDLISRGIDLPHVNHVISYDIPADMRKYVHRVGRTARAGKAGNAWSLIEDSEVAPFKAIMKAAQHWERIKRVRLKDSDVEHFVEDYQVALEKLKRYFATGQAARKEVVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJM2</accession>
    <name>A0A2X0MJM2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C033g11176 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C033g11176</name>
        <name evidence="2" type="ORF">BQ5605_C033G11176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000066">
        <property type="protein sequence ID" value="SGZ01954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJM2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016046925" evidence="1">
        <location>
            <begin position="23"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ01954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="165" mass="17877" checksum="E216F3AE7C890949" modified="2018-09-12" version="1">MLLLWLRVAALALAATGGPVSASPLKALDNALSSLNSTGPASKLTPIPTPPTISLLWKSKTYYPGDTVPFKWDRAAPTMQSADLFIAYSGPLATVPICVTRDMLLQPDRGSMVLHSAYVIPWKELLGQKGATVEGFIYFVYSPTHYRRDVGVAGVKSDSFTIQHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJQ0</accession>
    <name>A0A2X0MJQ0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C020g09082 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C020g09082</name>
        <name evidence="2" type="ORF">BQ5605_C020G09082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000082">
        <property type="protein sequence ID" value="SGZ16942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJQ0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ16942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="461" mass="52391" checksum="EEE9FEAC707DF09E" modified="2018-09-12" version="1">MSVQTPRPVRGPPCRHPSIEFRASPLRSASRASPTTPAPNHSTKPTTVLGYWRPRLTQEDRRDSSELCKKIKIEAIAALFDLDHIGNRDRYDAMFVTAPTGSGKSVIFEAMYLIYGRRAVTIVAADPNRKGKKAVVVSEETWRDDELYRQLDDPNHTISFILIRKGRGGRSRQRSIGITFLEPRKDARKKDAASNPEQDDTTPDEISTSGMHGDRPRLELLTENELSIRFFYESKACLHALAIVLYTQGELPLNADDPLIVAEMERQGNITGRSCQCSRCDCKARGFLPGSRKKVMEFWGLVLDLNYDCLILSIILGARLHAVLPIVQGLNDSQGAKYIIEHLRYTTEESYHEFSSYDGATIEADKMSQPTQNSQVENAEDDLEDFADERATQSVNRQTRGHNPWRMKSHQRDGFVEKLLLEYRQYTRGLNYGPTENCLRRLHRAGRRCNRMRGLREPSHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKB9</accession>
    <name>A0A2X0MKB9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C021g09323 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C021g09323</name>
        <name evidence="1" type="ORF">BQ5605_C021G09323</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000083">
        <property type="protein sequence ID" value="SGZ21030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MKB9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ21030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="92" mass="10471" checksum="6896BEE041F02FFA" modified="2018-09-12" version="1">MCFGTAAGRNGDRCQPLRSEHKEDADWLHDLPSSVPSLRATNDLSIEALKKKDWHEMCSDGYERNKTVLKKGDSDSRLVGSLDWPRRIRDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKK2</accession>
    <name>A0A2X0MKK2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01395 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01395</name>
        <name evidence="2" type="ORF">BQ5605_C002G01395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY32659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MKK2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY32659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="407" mass="44788" checksum="B879CD3BD5F24826" modified="2018-09-12" version="1">MTVKHGHDCVGNALEVVPDAVLSRETNLSSALVSLVGKIDGKSLPQSPFTALAIIDGATAFARQRKAATDRAKHNEPKRGRLFLNAIIRHLEEIIAATARRIQVVVVFDHPILRPKLNQDTVLDRQDRQKLQEPSDKSTPVTHPIPFITNDTLAACIHGQSSKEWEVSFRHGDEPTRVATFVRWSEQGLLVVAAHEADPLVGVDQTATFSCFSAPTKPVVVPCYRARTETLAWWTLRCDAHPAVWKSRQRFVASLIFGCDYFGGITGIGPTGLRDLPGQWLDAATWQSGWDGAAGALIRNVDSEPAPTEKRIKEVKSLCDEIDPIQDLLHHYKDERFAKATTASITAVSQGYRVRFEGTPHEDPSKVSRYAYAPIRRNPPLVHQPGVSSTGPLPSLSSLSTVQDPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKK9</accession>
    <name>A0A2X0MKK9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C030g10768 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C030g10768</name>
        <name evidence="1" type="ORF">BQ5605_C030G10768</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000069">
        <property type="protein sequence ID" value="SGZ08087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MKK9"/>
    <dbReference type="STRING" id="796604.A0A2X0MKK9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ08087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="152" mass="16591" checksum="34E791BE285EE4E3" modified="2018-09-12" version="1">MGYVFYLAGSAVSWSSKRQTRVADSTTDAEYLALSHAGKEAIYLTQLLSELHVRPINASHIFTDNEAAAAVAHDPVRTSGTRHTRLREHFVRDMVNRGDISLSHVGTANMVADLFTKALGPKIFGTHCYALGLRTRHPRLKSTSRSRGGGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLH2</accession>
    <name>A0A2X0MLH2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C023g09723 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C023g09723</name>
        <name evidence="2" type="ORF">BQ5605_C023G09723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ24439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MLH2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ24439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="137" mass="13830" checksum="B66BDD8772FF271E" modified="2018-09-12" version="1">MSDSGPILSVELDRDRRFFALALAMMSSVGARGRLEWGRDGEDYGCGSDVEDLELQLVGGGGGRRGGGGGGGRGRGGRGGEGRGEGGGAVDRGAAGGSERRRFRGMSPARASCCGGASGCGRRCRARGLHRAGSVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQ70</accession>
    <name>A0A2X0MQ70_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00262 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00262</name>
        <name evidence="2" type="ORF">BQ5605_C001G00262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY45205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQ70"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY45205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="267" mass="29495" checksum="2CD87C760F29F7D3" modified="2018-09-12" version="1">MANASPRPTPLAAPSTLRNRADSGFDPASIPYRAIVGKLLYLSGTTRPDIAFAVSKAARFCNDFTAEHWEALKHILRYLVGTRNFGIRYQKSFQPMSAILEGFVDADHGADPVTRRSVSGYVFMCAGGAISWIAKRQTLVTLSSTEAEYVAMSYAAREGIWLRRLLADLGFEQTASTRLRGDNQSAITLAKHPAFHARTKHIGIHFHFIRDHIAEGTIEMVWVPTGTMAADVLTKGLGTQKHYQFVHAMGLIDSSREGASWRVVNED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQM3</accession>
    <name>A0A2X0MQM3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C001g00402 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C001g00402</name>
        <name evidence="8" type="ORF">BQ5605_C001G00402</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY46244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQM3"/>
    <dbReference type="STRING" id="796604.A0A2X0MQM3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15849">
        <property type="entry name" value="SNARE_Sso1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF307">
        <property type="entry name" value="PROTEIN SSO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="7">
        <location>
            <begin position="165"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY46244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="263" mass="29606" checksum="DBD6883388E19099" modified="2018-09-12" version="1">MQSFFAEVEEIQDDIKQLHQYVNQISDLHSRRLATTDDAQQSESSAHLQELTQATSSLINSIRDRITRLNNLNKQSPPGDAEFNTRKLQVGGLQNAFRRGLEEYNLVEKKSREKYRQRVERQIKIVKPDATQAEIKAAFDDQQAGQQIFSQALVSSRQSGARAAFAEVQSRNQDLRKIEETITQLAQMMQDMATLVLEQDDSVKQIEATAVQANTDVEQGLQQTQKAVKSARAARKKKIFCAGIVVAIIVVVVVVVVVEVRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MRA4</accession>
    <name>A0A2X0MRA4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C019g09031 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C019g09031</name>
        <name evidence="1" type="ORF">BQ5605_C019G09031</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY24288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MRA4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY24288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="131" mass="13836" checksum="450F4D9281E92DB0" modified="2018-09-12" version="1">MAAGPLDVVRWGTASVARTEFATVPGRGSSTTVRGEEVERELLPVGEAAPARELIEDEIGDGMPGRALTIQDAIDVRPEGSSEGDEAVDECEFPTVAAATAAGPGGDDLFRLLPINRYKSCHCQPFLAEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MSH4</accession>
    <name>A0A2X0MSH4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C006g03868 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C006g03868</name>
        <name evidence="25" type="ORF">BQ5605_C006G03868</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY54348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="363"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="46"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="598"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="640"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGY54348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1389" mass="152336" checksum="2E21FEEF78646017" modified="2018-09-12" version="1">MNGANDKEQTEAPASALAAARQEADPGQAPPCNSNCACGQQPHTFATAGQPRGHAGPTRNSYRSGGHGRTGTRVGAKTRAEHYANSNKWGKIVDGKFMCANNQCVNCFGFGHRRAACDSRNPTGDRIAFLQSLDINVPVASHETYFVEDPVPMSLANHMGASFHFTNYAAEVREQTIFRAATAEAPELIFDTGATTSLVNDKCMLSDYATLDCPIFMIDAAGTRTPAVGRGTLTAEFTLADGTTSKMTIADVLHVPNFVVNLISGPSLCKQGVRIEMEEGRCEFSKYGQTFAIAQLVGSKYIFQARLSNLNPTEAQSLTVSMERKETVMGLNIKGEDFDVAKCHGCMQGRGVHANISRGPASRANKPLHAIHADLWGPVRHESFAGEVMVLGLVDDYSRFRWSFPIGKKSSVTALVVGFIQRVERSRDCNVAIFHSDNGGEFVNNSLKAFFWERGIEHRTTVPYAHYQNGVIERGWCTMFETVRIWLLVSGLPLSFWAFAATAFTYVSNRRPTAALPGSTPFEMYHLRKPNVSRFRVWGCVAYVRIAPERRASKIEPPRVKARFIGYAEQGWMFWRPDTNTVFVSDDANFDESSFKLHRGNSDDADLREDSPTTLFGDPPTGSLNIDGDDAAPGTDDRATAPIAARRAFAPDGDSRDNTPPVGRARAPDREYTPAAPGCERAPGNRVQHSNGQELTPIVPTRRAPAPVVSNGRAPAPVAPNGRAPAPVVPNGRAPAPVAGDGGAPPPVASRRPSPFLDNDADNDPPDPNPIPDGYEPVVPTTERTSELAERWGAPAGSRRRGGAEQQAMFVDLGTILGDIIPLNKLPEWEQVLSVVVNLEECNGWTNLSSIVQGSTEGICGIEELEAYQVWTGSPDEPTYKQAMAGKDHEDWSISLMTEYLILNGMNTWDKEATDPPPGVRAIPTKVVLVRKRNDKGDIIKYKAGIVARGDLQNHHGETFSPTARIASIRMINVIAHVKGYRWLQFDVNSAYLHGHITKPLWIKLPDGSTHRLRKSLYGLKQSGREWNKVLHAALVDRGFKRMEEDFGVYQRVRNIGGVDRTTLLAIYVDDGLLAGDDDLEGFLSEFDQQFKLKRGEVELFLGMKIATDDASGIMTIDQCHQIETILNNHGFANASAVATPTSDSDQHSDGGTAHLKLNYRQVVGELLWVSGCTRPDISYAVTQLSRHCADPKPEHFRQMRRVLRYLRGTINRRLEYNRHLGIDVTLYCDLDHAAEKSGRRSISGYTVIMAGAAITWASKRQVSVATSSVQAKYQALSAAARETLWIRSLLFSLGFPPSSPTGDSTGAIALADHPTSHATTKHIATHYHFTRELVSNGIIELRWIGTKEMVADGFTKGLSRAPHESFVRMLGMVDAPRQGACWKGLREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MT46</accession>
    <name>A0A2X0MT46_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C042g12002 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C042g12002</name>
        <name evidence="3" type="ORF">BQ5605_C042G12002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000116">
        <property type="protein sequence ID" value="SGZ31795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MT46"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1173"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="617"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1752"/>
            <end position="1777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ31795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1996" mass="223471" checksum="546CAF3482F95EFA" modified="2018-09-12" version="1">MMNVFYKKKNPDRPEITALEIQPREDIRRCRGDEIAIYEPQSKKKKTDKGELVACVRTLLSPNTPICFDTGVPLSGDLEAFMPRITGLQHSSTFRTGVLHHRITVGFVSAEARDAALASAPMLVWNSANARFAKAHPFHRNMLEMRINVGVVRPPSKEQIVAAFQSIVQQLSTKGHSCQLVQVLRVIHVDTAKAYAHTVGDFSAFIHFDDASLFQHPTTTLKEILPSRMDLPTRGLDVTAVRHDYEKEAPCARCHFAGHVERCPLMQAANRKEAEDLARHAVMRGAGMVGGGEQTGVGRAATTTTNNIRPTANNNNTSEVVAPSRALGTDQLESRNRFAGLEVEGGQEDDIEEEDAGKEGEEKEQVKEGDEDTGAKADDEDSDSDGNAGAGIDKAGGDGKDDDKDDDEDDDKDEQDDSSEGSERRGDDVMKDGAEEEDEGMETEVEEEVEQEQGVQDDRIMIIDDGQTTITTVSRESTPRSPSWPPLSPETLAKSLREGAEWDRANAEAAARVQAENEAIINAQLDAQEPLVRHQFAEWGQEDGQLRFINIRGTGSRSNKKMKRSQTVADLSDPSDGPVDVKRVLNRVKGRAGKEVAGQGKRVTRSMSAAAAMQVEGAKAKAEKGKGVEEEKRWSDHEPEDDILPEFPLFEDNITAKSTWNVRRCMGIPEKRRDIYTYLSTFKASAILLQEHFIKPELWQCIKDEYEGKAFISKHCLTLIPADSPLIDAEILRTHSALDGRILVTSFRLRGDIRILEINNLYAPVDTKQRLTFFDKLHFHRTQSTHLRLLGGDLNDCPLPAIDRRNQGRHGHHWPILIGKLDSPYTDCIRFKHPLTPSFTRPNIVRKRPKSFSRLDYFLLQRTHQKRLVQASTIYDHPKDLSDHRPVSIVLVLSDERGDAAEPNNSLPTTSNQLHRINAATFKTAAFQGMLEGWLEGASGEEPVGELEVVLGNCEKEGRELARREHRERVERMAVLVGRVQDLEALPVMGDEETAEWTRTTEELRRAVNERARQLRIRAHVPEIATEERLSRPVHAKLAARSSDSKITALRLPNGELTHDIDVALDHTQAHFQRLYNLEPRDRDHVERLRDDFLAPIRAARTCDDPSSDPLFLRRLSEAHIELLQQPITEDEVVAAIATTHPGRSPGPSGVPYELYHTAPRAWAKALSRAFNAMTERGSLSPRQGQGLVRLLFKHHKIGADRAELSSYRPITLRECDYKLFTKVYVARLNHVLPDLLPPQQHGFVKGRRSADASFHLRLLIEELGARGTEFPDAALLSLDQSSAYDLVEHEWIFAIFDALGAPATFQRVLRMLYSGDSTTARYIINGFLTPPVRLTCGLGQGDPASSSVWDVVFQPFLDALHRRGIALNLSLPTIHPYPQSRAMTSLAFADDVVVAVADSESLTLLDDLALDWRLATNGRLNTDKTVVLPIGCRWEAGDRPLVVKAEGESLEWIGLSFDPTGNTELANVNLVARLEAVLDSARDRGLTHHTRAFYVNRYAIPKILHILSADIPPLEVVKELDRILVDFVRGGKRRACYGKDVVFTPRFKGGLGVMRMQDVVDSVAARVWDVLLGGSDAIWQGLARAAIVRAHPAPDFDLTTDAWPCDYTPIRTDLHPRWQAVLKVPSTHNAQVKPRTLTLANLLALPIKLHTLHYLPGAPAVSRSPYDVDYAAFAIYAKVADLFRRELYPGGGFHLWTPPTDVVVSNSEYDQRGRPQREHIVAWYRHAINRLRFTPIAQPVAAVRINGPPRVRPRSEVRPTTPLESILPHPIDPPQRLPRPALPDQSTQYNLLSMDRPYTIRRVRRVLNAKAFTDTIGFRDSLQPDDIKGFWKGVNSKALTAREREVWFKLVRNFTPTRSLQFHQKHDDSPACLVCGAPKDDREHYFFDCVDSGNVWIAARGVLCDALGLDTIDNTHYTAVQRMFGLPKLKASLRDQEGAGRTIEIFTGLVLEMISSGRWGMQKWGTRMEGVVRRRIILEERLKLRAGGAWGRRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MTQ3</accession>
    <name>A0A2X0MTQ3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C041g11938 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C041g11938</name>
        <name evidence="3" type="ORF">BQ5605_C041G11938</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000119">
        <property type="protein sequence ID" value="SGZ33160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MTQ3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="201"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ33160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="792" mass="86483" checksum="79637F13D752A19A" modified="2018-09-12" version="1">MSAVDVAPGYTGGTLLNSTDAESPSSPSPAPSSSPSPEPASSPSPAPSPASSPSSAASSSPSVSPADSEYSADPLDLIGSQPQAPPDPLDAQPPDFSTYREPASAEESPDELDLIGRHSRDESPDEIDFLARHHRAFIATDDDNPEAEAIQPVKSITSDPQTWREAMSSDKREVWAKAATAEFNSMRDDFKVFTIDDRSTVPAGATVVTSKFVWKTKRNALGEITGHKARLVAQGNRQRDGIDFTDTFAPVARFSSIRSLLALAATNGLHVHQADIDKAYLHGDLDHDIWMTAPRGFDLPGDKVLRLRRSIYGLKQAGRIWNRHIDALLRDLGYTATGTDHCVYSRLDDRQHPHYIALYVDDLLMISPDLAEIERVISGLEQRYSVKRLGPAEYILGIQIRRLDDGSVALSQERYIMDVLARFHFDTTTRGTTVPMTPGLSLTAVPGQATERIRSWYLQAIGSLLYISLGTRPNIAFAVSYLARFANNPGHRHWIAVKHILRYLRATYRDELVYTRGQARITGVVGYSDANWGACVDTSISTMGYVFYIAGSAVSWSSKRQSRVADSTTDAEYLALSHAGKEGIYLSQLLEELHVQPVAPAHIFTDNEAAAAIARDPVRVSGTQHIRLREHFVRDMVNRGDISLSHVGTSDMVADIFTKALGPKVFSTHCYALGLRTRHPRLGSASHSRGGGVGDCLIAAHIFTDNEAAAAVAHDPVHTSGTRHIRLREHFVRDMVHQGDISLSHVGTANMVADIFTKALGPKIFGVHCYALGLRTRHPRLKSTSRSRGGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MTX2</accession>
    <name>A0A2X0MTX2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C040g11894 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C040g11894</name>
        <name evidence="7" type="ORF">BQ5605_C040G11894</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000118">
        <property type="protein sequence ID" value="SGZ32606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MTX2"/>
    <dbReference type="STRING" id="796604.A0A2X0MTX2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057683">
        <property type="entry name" value="DUF7923"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057654">
        <property type="entry name" value="Znf-CCCH_tandem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543:SF1">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25540">
        <property type="entry name" value="DUF7923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25543">
        <property type="entry name" value="zf-CCCH_tandem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="363"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="363"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="284"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="302"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="460"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGZ32606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="471" mass="50679" checksum="499EF5803528D473" modified="2018-09-12" version="1">MATPTGGPADAFASYVALQTQALDIVREACSGREELVQRIADLELELNVWKDAQRKEVALRENALRALRALEDSESLAVCLIDGDACLFSRQLIARGRDGGRDAAQALQKHIAELASKTSTGNGKPTVICQVWFNKQGLSRVFQEMGIASDATFSAFIQGFNQAHPLFLMTDVGGLKEACDAKFRETLRMYARMMACKLLVLGCSSDGGYAHQLQSLKTEALDWKVHLIRSSEMAFAIKQLAIQEVEFEDLFERKKLIVSMPHTSSSSSSSSLMPTVAAGPSELKSSASTFGSAPKTPKKGTTAAASNATPSASTANNAGTGFIPVTTTKRVKDKASISDKENGFIKITGKLRAIDPKKPLSRQNPPPCNIFYLIGECTRGDSCPYAHDYHLSAQNIATLRIDAKKSACYTVTKGRPCTDPLCVAGHACPAGLACKFGSTCKFPASMHPNGKFIKKGTRSPESSGYDTESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MUB1</accession>
    <name>A0A2X0MUB1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C066g12823 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C066g12823</name>
        <name evidence="3" type="ORF">BQ5605_C066G12823</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000134">
        <property type="protein sequence ID" value="SGZ35286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MUB1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="332"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ35286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="441" mass="48565" checksum="52E458CC4EAEC949" modified="2018-09-12" version="1">MFVALRFGYWDADRESKKHPDIATSKWCNYQLRARVYPRSLTHLPRKVCSSWACPPASQDVRAISLPARYVSGAILSQALLDLIFHTRGIAYWPRRPCLTPRMNNRNNNDTSNATPGAIALIVLPTPPASPPPPKPGRTPRPSPPVPMRRPTPPPPPRPLVASHPMIHNIANCVIIKTPPATTSEKVLSALDHHYPSLAGAMPCVIKGQHGIRFPKDADIVGRVANGLTVGKTLCQVEKLFSATTGVIQCTLSGFFSDVEGLRLFDEQIAEYGKVLLRRTHYIGKTRHISGVYDFRIPLRITGGMRHCVFCRSAAHVRKDCPVAPACKSCASTSHASQHCPGRRLASRPPGHSRVTSSASLHRDQKPPGLQVDPCTTRARPRVETKKRRVDPDQDLAAQPQIHPTGLSPNPCRRLLARVLLQFPPNSAPLPPPTRELPLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MV05</accession>
    <name>A0A2X0MV05_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C005g03160 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">BQ5605_C063g12769 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">BQ5605_C070g12869 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">BQ5605_C104g13165 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C063g12769</name>
        <name evidence="3" type="synonym">BQ5605_C005g03160</name>
        <name evidence="5" type="synonym">BQ5605_C070g12869</name>
        <name evidence="4" type="synonym">BQ5605_C104g13165</name>
        <name evidence="3" type="ORF">BQ5605_C005G03160</name>
        <name evidence="6" type="ORF">BQ5605_C063G12769</name>
        <name evidence="5" type="ORF">BQ5605_C070G12869</name>
        <name evidence="4" type="ORF">BQ5605_C104G13165</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY72334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000079">
        <property type="protein sequence ID" value="SGZ11564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000125">
        <property type="protein sequence ID" value="SGZ34472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000139">
        <property type="protein sequence ID" value="SGZ35603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MV05"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1268"/>
            <end position="1553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="650"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="712"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1847"/>
            <end position="1872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="713"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY72334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ11564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGZ34472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGZ35603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2091" mass="232155" checksum="739EB38084F64A7D" modified="2018-09-12" version="1">MQTGDPGSAPGARAPPPPASAPTSLPIAGTKETQATQVAGRTATYAAATNSSVVSNETPAQQQDRLARLQALPGILAAIQAVPGNRADRFVQAIFATPDFPSTVATALKFSALNATRNIINPFANALEVSLSHKSTGRASATDKGELVACVRTLLSPNTPICFDTGVPLSGDLEAFMPRITGLQHSSTFRTGVLHHRITVGFVSAEARDAALASAPMLVWNSANARFAKAHPFHRNMLEMRINVGVVRPPSKEQIVAAFQSIVQQLSTKGHSCQLVQVLRVIHVDTAKAYAHTVGDFSAFIHFDDASLFQHPTTTLKEILPSRMDLPTRGLDVTAVRHDYEKEAPCARCHFAGHVERCPLMQAANRKEAEDLARHAVMRGAGMVGGGEQTGVGRAATTTTNNIRPTANNNNTSEVVAPSRALGTDQLESRNRFAGLEVEGGQEDDIEEEVAGKEGEEKEQVKEGDEDTGAKADDEDSDSDGNAGAGIDKAGGDGKDDDKDDDEDDDKDEQDDSSEGSERRGDDVMKDGAEEEDEGMETEVEEEVEQEQGVQDDSIMIIDDGQTTITTVSRESTPRSPSWPPLSPETLAKSLREGAEWDRANAEAAARVQAENEAIINAQLDAQEPLVRHQFAEWGQEDGQLRFINIRGTGSRSNKKMKRSQTVADLSDPSDDPVDVKRVLNRVKGRAGKEVAGQGKRVTRSMSAAAAMQVEGAKAKAEKGKGVEEEKRWSDHEPEDDILPEFPLFEDNITAKSTWNVRRCMGIPEKRRDIYTYLSTFKASAILLQEHFIKPELWQCIKDEYEGKAFISKHCLTLIPADSPLIDAEILRTHSALDGRILVTSFRLRGDIRILEINNLYAPVDTKQRLTFFDKLHFHRTQSTHLRLLGGDLNDCPLPAIDRRNQGRHGHHWPILIGKLDSPYTDCIRFKHPLTPSFTRPNIVRKRPKSFSRLDYFLLQRTHQKRLVQASTIYDHPKDLSDHRPVSIVLVLSDERGDAAQPNNSLPTTSNQLHRINAATFKTAAFQGMLEGWLEGASGEEPVGELEVVLGNCEKEGRELARREHRERVERMAVLVGRVQDLEALPVMGDEETAEWTRTTEELRRAVNERARQLRIRAHVPEIATEERLSRPVHAKLAARSSDSKITALRLPNGELTHDIDVALDHTQAHFQRLYNLEPRDRDHVERLRDDFLAPIRSARTCDDPSSDPLFLRRLSEAHIELLQQPITEDEVVAAIATTHPGRSPGPSGVPYELYHTAPRAWAKALSRAFNAMTERGSLSPRQGQGLVRLLFKHHKIGADRAELSSYRPITLRECDYKLFTKVYVARLNHVLPDLLPPQQHGFVKGRRSADASFHLRLLIEELGARGTEFPDAALLSLDQSSAYDLVEHEWIFAIFDALGAPATFQRVLRMLYSGDSTTARYIINGFLTPPVRLTCGLGQGDPASSSVWDVVFQPFLDALHRRGIALNLSLPTIHPYPQSRAITSLAFADDVVVAVAGSESLTLLDDLALDWRLATNGRLNTDKTVVLPIGCRWEAGDRPLVVKAEGESLEWIGLSFDPTGNTELANVNLVARLEAVLDSARDRGLTHHTRAFYVNRYAIPKILHILSADIPPLEVVKELDRILVDFVRGGKRRSCYGKDVVFTPRFKGGLGVMRMQDVVDSVAARVWDVLLGGSDAIWQGLARAAIVRAHPAPDFDLATDAWPCDYTPIRTDLHPRWQAVLKVPSTHNAQVKPRTLTLANLLALPIKLHTLHYLPGAPAVSRSPYDADYAAFANYAKVADLFRRELYPGGGFHLWTPPTDVVVSNSEYDQRGRPQREHIVAWYRHAINRLRFTPIAQPVAAVRINGPPRVRPRSEVRPTTPLESILPHPIDPPQRLPRPALPDQSTQYNLLSMDRPYTIRRVRRVLNAKAFTDTIGFRDSLQPDDLKGFWKGVNSKALTAREREVWFKLVRNFTPTRSLQFHQKHDDSPACLVCGAPKDDREHYFFDCVDSGNVWIAARSVLCDALGLDTIDNTHYTAVQRMFGLPKLKASLRDQEGAGRTIEIFTGLVLEMISSGRWGMQKWGTRMEGVVRRRIILEERLKLRAGGAWGRRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MV43</accession>
    <name>A0A2X0MV43_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="22">BQ5605_C003g02009 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">BQ5605_C003g02009</name>
        <name evidence="22" type="ORF">BQ5605_C003G02009</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY38363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MV43"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0229">DNA integration</keyword>
    <keyword evidence="18" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="16" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="15" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="16" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="17" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="21">
        <location>
            <begin position="658"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="SGY38363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="823" mass="90054" checksum="478D7945B846A42B" modified="2018-09-12" version="1">MRARNVAFIGNLFRSACLFTSQPLSLQLIDGWTTRSSVSLFEKTQRISKMATTTVDSGSATHCGLMGDMYGNVDATNWGTAKDRLQRVLEGDGRFKHVTTELSVGPKPKQSEFTRTLDGSTVAYVATFRTQHRNYRHDVNDLDQALAQARNILFAALDKDLGAASHDFARSAKLDALFQYQAYVDGDPLDPWLLRFNRLFIDLNTAHVSRDKAYQRAKIDGVNYTQAEFDKRIPPPALSEGIRMDLLKARMPRPIVTVIDTLGPIPLLSDVEGVIRCAAISRSSGTDVAEALTAKTQGRRRRPACSSGKLKSSFLLASKVPGLVDKWPHGVAQNGRLRLGPSQCRKCYEQGHLGDKSKHNISIGAADAMALVAEYGPDPLVDNKSYDNYSVDVALDTKVSALYLHDGPCYLLDSGAMCHMTTRWDLLIDFQPFTTEQVRVVGAFKSSAMAVGKGTLCFDTNGAPLELRNVLLVPGLSAKLVSLASLMKDGYQLSGICDAASEHSGLTVSGLALSLTFALDRDHYILQASPDSPPLADHQALTATSLPTDSSDISLDISAVTRDQLRLLDQCNACCSGKAVSAPSREAAHHPADAPFARVFADVWGPSPVPALSGIRYLCGITDEHSRFRWARGIWLKSEASSVLKGFVGDLAHGEGGFVNNALRDWLADRGIFHELSTAYEHGQMGIQERSWRTIFNSVWAWLHRSGLPSLLWEEAAQAAIYVINLLPSSPLQQRTPDAVLHAAASPVTSTRRPRIDHVKIWGCAAQVPFAPKQCSNKLAPRSCLCYFVGYSLRSKAWRFYDPVGNKVFESSQYSINSTTSAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MZR9</accession>
    <name>A0A2X0MZR9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C008g05315 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C008g05315</name>
        <name evidence="1" type="ORF">BQ5605_C008G05315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY80161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MZR9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY80161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="52" mass="5725" checksum="219F2D3DDA5E919C" modified="2018-09-12" version="1">MLHFRVEAASKTRGPLNLVQSIEHVAVAVTRSPIGKVARPNREMMSLKPSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N0I1</accession>
    <name>A0A2X0N0I1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g04200 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g04200</name>
        <name evidence="2" type="ORF">BQ5605_C006G04200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY56942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N0I1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY56942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="249" mass="27862" checksum="F2D30B816C6385C9" modified="2018-09-12" version="1">MAVSRVRIHVKAHKSAPRTCRRIFVATSFFYKQSTSAESFALVLTKSGLVPTEAYNKNLPFRHNLLSNIPALLVQGRGDLLRHIHKSQQDKATLGRTIKQWYKGQQVAVTEGHVTWWSILWQAMKAPNISNPSDSKANSFANKLKRYGDSLAEDAADAHHAGRYKRNGGFDHQAFLFDTVTAKMKRHSGIRTGPQSTLSDHALQAVCSEVVEDPVNNLSFASRVADAVQEMGENSGKARRKKRTEDHQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N1N5</accession>
    <name>A0A2X0N1N5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-rRNA-processing protein PNO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pre-rRNA-processing protein pno1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C038g11718</name>
        <name evidence="11" type="ORF">BQ5605_C038G11718</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Required for small ribosomal subunit (SSU) synthesis. Has a role in the processing of early nucleolar and late cytoplasmic pre-RNA species.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the small ribosomal subunit, ribosomal RNA processing complex (SSU RRP complex).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000061">
        <property type="protein sequence ID" value="SGY92140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N1N5"/>
    <dbReference type="STRING" id="796604.A0A2X0N1N5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22391">
        <property type="entry name" value="KH-I_PNO1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22392">
        <property type="entry name" value="KH-I_PNO1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000009">
        <property type="entry name" value="RNA-binding protein PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055212">
        <property type="entry name" value="KH-I_PNO1_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055211">
        <property type="entry name" value="KH_PNO1_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826">
        <property type="entry name" value="RIBONUCLEASE Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="RNA-BINDING PROTEIN PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22891">
        <property type="entry name" value="KH_PNO1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="10">
        <location>
            <begin position="243"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="99"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY92140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="338" mass="36473" checksum="D41159EADCD94B3D" modified="2018-09-12" version="1">MSNTDFLPASASSSKSRKQALKASSSSSASNKSNKNVSTFLPTQPNLSSDLNAVPSASAIASDSILAEFSERLPLYDTKVAPVKVNARSKNTRAQEADAAMAVDSDPEADAEEDDSSVLIDPSSLSLPTPVTRTPISQIPGSDALSFPAVSHQTKAGLTQRRKIGIPPHRMTPLKRDWIKIYTPLVEECGLQVRMNVGKKCVEMKTSKHTPSASSLTRASDFLSAYALGFAVEDAIALLRLEELYVESFEIKDVKTLHGDHLSRAIGRIAGHEGKTRFVIENASRTRVVLADTKIHILGTYSNIKIARDAICALILGSPPGKIYAGLRIVASRSRERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N372</accession>
    <name>A0A2X0N372_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C004g02904 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C004g02904</name>
        <name evidence="9" type="ORF">BQ5605_C004G02904</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY68622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0N372"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000196">
        <property type="term" value="P:cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000182">
        <property type="entry name" value="MAP kinase kinase kinase mkh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000387">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF48">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE BCK1_SLK1_SSP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="1351"/>
            <end position="1627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="261"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="994"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1208"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="348"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="427"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="451"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="525"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="536"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="549"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="644"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="678"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="769"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="805"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="841"/>
            <end position="853"/>
        </location>
    </feature>
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        <location>
            <begin position="858"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1095"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1134"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1229"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="1380"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY68622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1661" mass="177434" checksum="D95C6C21ADE10207" modified="2018-09-12" version="1">MQQDDRRRAGGGGGGGGGGSRPSATSYTGNNQLSSTQPRNDYSQPSPSSRAHSGLMSPISGSSSSSSSSSSRIPQQPSSNDGTRRPSASDPRYRRDDSMLHSPYGPPSGNNMYPPQHGQGSSSASARSPRLPPLQYPHQHSGWSGDALGRTRANSNSPQSPSSRTFNSPTLLPGTSLWATKDLDEDLKRVNLDKCTSGEAIRETIFSRLEIADSDASRYEVRLTTVDGDAGRPISTDEIWDLWSSGRGKGRAIYLREYVPDRRGDDDDEIPVGMSAERLNQATRSKGGRENSHSGHPPGRASSPVATRPPHVSPAREHSPRGGQNEADHAQGSTSLRSDRPSWTWGPSQRSGHQRSSSSGNQLDTVSHAHNAPLDPRHDRSGDATPTPDEFGRANNSSSSAWAHSPPLGSSGSRFETFGGGGGGSGNHNAPSSRNPVPQVLSPAGGAPNAPSETLSSWSRTNTNTGGGSARAYQFQQSSHPPPPLHPMHPADARAVLPQYQPYVKAGRAPPSAPVFHNLALQQSNPPPPVHPTRPTPQSSQSSSTLLSPNQRQMMSKSVDNLRGQFNSSAPPGYPGAYGSMRSPAPVPPAPPILTSQPYRSSSSQPVPAQSPMPFNPRIMAQNSTPTPAASYYRSGLGSYTNSMPPPPLPPRGPYTTSSSIPPIGQVWPTPTRRMDRPSNSSANPTSPASNLPDLTRRLDLQPGQTLQAAGTRQRGASDAAPPSAVHMMSHDPSAPDPAQLAHRRASSSGLDLVDRDRYGSVPTPHRNSGSSSTTDSGASGRGNAPLKALKAKGQFQQLQHGRDSSSSSFASSTSSASNTSSSRWRGSNASPTHAMAGQDDGSRFGSNDDERPPFASPPSSARSSTSASVNGPLTPAQDNPPLDSGGVRTPSIPTVVLHSGQSPPLLDAFGDPVDEESATWFPVNQPAPKAPATKLTSEVASALRKQASAPSVRPAEMIDEQSETMREGEWAKEARKALLERLNIEDADAAGTMVRTDQNAASTGKDEFGDDVDEEGGTFMPGFGPARTATVDEQPARISPPGQVSYTLRDEPASRLSSPTVGTPTRRPNLRLEMPSEPASSCGVETATRLNQWSSGTSVSASVMSAAPPSSARRSAGPGSDGSGDVSTMLSSRRAERSEKLRHTSNKADRTISLNAPSPGMGSRRGSFRDRADDENLSWAVRPAVETVLENLDVYFPNVDLDKPAFAMPAPAPGTPSPGKETAPPAPATVSSSSSSSQASSQVTTASTAATSVASTAFSPAVRRALNNSGLMQRKSIRYVAQDRKRAMQKAGRTMATVVHGLGSSLLRRKSTKLFGARIEEVTGADLGRLSNTIREDVGEENPDNFSYKWIKGDLIGRGSYGHVYIGFSVTTGETIAVKQVELPKTQSDASNERTKSMVASLRGEIELLQDLDHPNIVLYLGMEQTPLHLSIFLEYVPGGSIGRIVRTHGKFEEDVIKFFTMQILEGLSYLHGLGILHRDMKADNILTDHDGMCKISDFGTSKKSSEFDLACVADIYNNDENMSMMQGSLFWMAPEVIYNMKTGYSAKADIWSFGCILIEMFAGRRPWSEDEQLQAMFKIATERRRPPIPSDVTLSSEADEFINNCLAINPDERPKAYELLRHPFLTLPETWSFTQSSLYSVMADEEQRRHAAATNASNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N3S9</accession>
    <name>A0A2X0N3S9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C004g03104 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C004g03104</name>
        <name evidence="2" type="ORF">BQ5605_C004G03104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY70106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N3S9"/>
    <dbReference type="STRING" id="796604.A0A2X0N3S9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY70106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="264" mass="29267" checksum="8A0DEBE26E7DF01D" modified="2018-09-12" version="1">MLPACNPGCWMARGLAQHGGWCGLQQVHLIPGLTIFCSLTLSVVYLDSKPTDHTICCLSCLLPATRQRLPLPSAGEVGTAVWHVLQRRQISFKERLDRLAERDDLSVVWFRTRSPAVHESRPSAFGLIGGLFAGRAKQVLRRSRGSPRHFGRRFSTLNNTQMQSLVAESSRRSSGPSAVDVRHTIIDLDAFRRELGLTPDPAAEQAERDRDDVYERRMEEVLGSRSEQEVEEEDDAELGEGGGESGSTRGEDSDDLEILDEPMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N6E3</accession>
    <name>A0A2X0N6E3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C008g05207 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C008g05207</name>
        <name evidence="3" type="ORF">BQ5605_C008G05207</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N6E3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY79709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="294" mass="32464" checksum="0C7AA0FD30FBC73D" modified="2018-09-12" version="1">MSSIHPYARLTIYYLVHTTIVLVSLLSLALTLTRAFLELLNGGLGILQVTLRYASKHLEDHECATEAWRDIGREELKVRKTGWKWPSNGAEVMGAFKGAGSVVRVVDDGMEQVMAREIMKNREVKSGPQRQAREEMLTLRKAVGAEPPGKGGLGSYAGESITCRVLAASTDHSHGASENTTPRRHSREGSVPPYTQPYIAPKIQQPLEYVMPIRSRTVEETDLFQLSSIANPEPLLSLVHATVRSATRRSVAGSLSSNGFFSEPFTDSAPLEHRREVVREGGCIWTAAGQWERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N6I9</accession>
    <name>A0A2X0N6I9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C008g05247 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C008g05247</name>
        <name evidence="8" type="ORF">BQ5605_C008G05247</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N6I9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008506">
        <property type="term" value="F:sucrose:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432:SF91">
        <property type="entry name" value="GENERAL ALPHA-GLUCOSIDE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="469"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="912"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="619"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="678"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="942"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="722"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="769"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY79902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="967" mass="103962" checksum="F6454C1103312C10" modified="2018-09-12" version="1">MTGGGGGLSFGRPRPSGNRATVLSSTSSPSAAPSPPSPSGTGAPTRRTRSRWVGRAAVLPTSPFASQTLKLIVVSLSMLGLQLVWSCEMAQASPYLLSLGVSKAMMSVVFVAGPLSGLIVQPVVGVLSDGCRSSLGRRRPFIIAGCAVSSLGVVLLGWSGQVAGWFTTHESAIQSHLTIALAVLSIYLIDFSINVVQAMDRALLVDVLPPNLQEAANAWASRMVGFGAVFGYWFGGLDLVYWSNGYLGDNQLKVSRSRAFFLCGSHAITITCVQERVLISRETVDEATGEGSKKPVAMLKALQEIWTTIKTLPRPIQEVVNIQTKSSQFTLSLAWYPIMFFSTTWVAEAYLRSLEGGGPIDLGNVSVKVRDDATRAGTRAMLFHSIVALATSILLPPFVASSAASFSSPPPRLRHPPNVSSFLDRLTKTWRRFAPTLPLPWLSLPLLWTLSNGLFGILLLSTYLSSSVFGASLIIAAVGFCGAITQWAPFALLGELILSLGATSTSSNPLHFDYASAGGIPTSTWNESRASLDDNYQAPYDDTLKASYGFQSNPTTTENEDDDNVQIARFRSTATSTVTSSIGSPNSATSAYFEAVMDTPMVADTPSLPLPPFHPSTSKIEVPFLNKTPTPPPRHDPPSELRIVTSPVARLPSHIDVDLFSSHPYNYPLHADEASSQLTLLPGDSRSATPMRRGSASSPLQILQVRHSDDENSENSSDSGDADGKKRDRRGVQDGGDEEMYGGRRGTIKASLADGAPTIMIDEDQDGLDQERAGEDSRDRLGEEDDEDLDGAADQAGAILGRPALFCRIHNIYVVMPQFLVTALSSIIFALFAPHQPIIHHGGSTTHPIIPADPGTVSPDDPLSGEGGELGERLIRRAVWATLNHLVPLLTRASDETPTGDDPPLERQYDPLGMIFQFGGFMALISAYLAWKMTRHWNEREREARSHHGALRGQGGPGGTMMRSDRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N8T3</accession>
    <name>A0A2X0N8T3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="5">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BQ5605_C037g11627</name>
        <name evidence="16" type="ORF">BQ5605_C037G11627</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the TOP6A family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="5"/>
    <dbReference type="EMBL" id="FQNC01000062">
        <property type="protein sequence ID" value="SGY94091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N8T3"/>
    <dbReference type="STRING" id="796604.A0A2X0N8T3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000706">
        <property type="term" value="P:meiotic DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00223">
        <property type="entry name" value="TOPRIM_TopoIIB_SPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013048">
        <property type="entry name" value="Meiotic_Spo11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002815">
        <property type="entry name" value="Spo11/TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013049">
        <property type="entry name" value="Spo11/TopoVI_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036078">
        <property type="entry name" value="Spo11/TopoVI_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034136">
        <property type="entry name" value="TOPRIM_Topo6A/Spo11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848:SF0">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21180">
        <property type="entry name" value="TOP6A-Spo11_Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04406">
        <property type="entry name" value="TP6A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01551">
        <property type="entry name" value="SPO11HOMOLOG"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01550">
        <property type="entry name" value="TOP6AFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56726">
        <property type="entry name" value="DNA topoisomerase IV, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52041">
        <property type="entry name" value="TOPO_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Spo11/DNA topoisomerase VI subunit A N-terminal" evidence="14">
        <location>
            <begin position="258"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Topoisomerase 6 subunit A/Spo11 TOPRIM" evidence="15">
        <location>
            <begin position="373"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="12">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SGY94091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="557" mass="61243" checksum="F288EEAFD59811CE" modified="2018-09-12" version="1">MELNEGNVLLDFDTEMPDSEDLAVIEAVGDVDRAAAWSYDIVGAPGRNLGSPPMESSFQQAGTLSSGLHHLEKNLAWTLKAPRVAADEAAVPPIVSLVTTNRLGSMAGNDTALCPQAELLLMDDLHDSNFSDGLHTQSSSDATSSFTSQSSRSSITSGPIELELLHCVHRFAPFEVELEPAGLVSTVASQPIQLQEVNQRRNNFAPRKVPRPEDFDPGGTICGSKRMCGTNDGKVNDYNPRCCTHQSTVAYMVRPEASVLKVIEYILDGFHRSVLASKRDYYYRAVELFGRQKVVDEIVDDIAATLCIRRSELGVGSSPKGLVSGQISLLMSNATVMQGSTSRTGTLIPPIDQIIGIRYPADGAEDYPGRIRWVLVVEKEAIFSALSSSSLLLDSILGRGVLITGKGYPDMATRHLLKKLSVDMPHTPIMALVDADPHGIEILATYACGSRSLRHEKEELVIDRMEYIGVKHDDLHNSNIDRDNLIELSVRDRKKALNLLKRADLKDDWRRELQHTLHRGYKAEIEIIASSSSDANNDQGLLNYVVDRVNSMLRHYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NBF5</accession>
    <name>A0A2X0NBF5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C028g10516 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C028g10516</name>
        <name evidence="2" type="ORF">BQ5605_C028G10516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000080">
        <property type="protein sequence ID" value="SGZ12612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NBF5"/>
    <dbReference type="STRING" id="796604.A0A2X0NBF5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ12612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="907" mass="101055" checksum="B1DC454105B482CA" modified="2018-09-12" version="1">MLPRRTIFEAKAWAVSPSLLAALSSSCCTGIATTEVRSSGRPQRRTSISSSKAIPAATPATPATPSRYSSSLCSSCHSESRPATSGSTVSATFATSSETANALPRPHWTSSPTNDPSSWDDLNSVPILATAAHRVQEVSASPPRPPTSEASSSTNPKHDDQVSQLEPLQATAALLEHIRRHRRSQRELPSTLPILEYTTSSSDLNPSPESHAHNHSEGKSTPIPPPPIAYLPHSSTDHSNLLTAFLLQAIFLGASAVGLLLRKKSTVQRVDDNIKSTPSPTFVAKRAEANLEAQKQRRTEEIDHVPALNLLLSSYVEFPSEQQPEAKVTLSSKETVVLNFVKHKMERLPHVAEVLSRFSEARARPDTWTTLAAMAFVEVPSAVLQACQLGSTETKDRFRELNAFSDKLVEWSWQAFLGAEKSGMSSEVKATLVSSFLQWAARTETIEEGDQNALAHRIIDYGSTSMSELTAVQRALLGQAALYHSRTGLVAQWLAADSMIDPRTRLDLAASTLKVLADHEEWHRRGDVVLYTAEALVTSLEQLCAPSSGDAIDPTLRVMLDECLTLLIHHFRIDAPLEPLYTRIIESLMTKDPTSFPSSCLRSFLESLITARQAKLATKVFLLIASPSRTLRQYEAMLRSHRAMTSDRVWSELFLHPTLEPTVSSLSARLSSHLLTCRHDLALQDFNLVRGRLRTKTLQAVSEQGRTLWTICYTKLYTLYVRTKHDVSLSRLRQRMKDDLGNEVVRLDKAMATGYLLREVLGRPWDVELRRGRVKGRKQVEKVRQRWKWIQNGERGTVGNEQERMISRGILNNVGLKGLVKWNTVVDASKILSIAEKVLGTEQEMGVERVGKMGNEEFEKVRKVAYKILMRALEERGAKDQCRMLRKRLEEEVGERRRVGRRDVMGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NCG3</accession>
    <name>A0A2X0NCG3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="19">BQ5605_C041g11931 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">BQ5605_C041g11931</name>
        <name evidence="19" type="ORF">BQ5605_C041G11931</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000119">
        <property type="protein sequence ID" value="SGZ33111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NCG3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016166020" evidence="17">
        <location>
            <begin position="28"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="18">
        <location>
            <begin position="91"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="346"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="404"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="462"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="404"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="SGZ33111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="760" mass="83726" checksum="7B10D1B9503B36FD" modified="2018-09-12" version="1">MVAGSKRAERNLLSVFCLFRLAFLSRSESTVPLLTLHRCLGHLAPSSIQKMIAAGLLDGFGAGYSDKDVEEFVCNACLGSKGHRLPFPDSESHSPERLGLVHSDVLSFPTPSLTGKRYLVTFLDDHSRKLWAYAINHKSDVFPTFQTWLAEVELETDARLRILRTDNGGEYRSNAFTEFCQSRGIRRQYSIPYTPQQNGRAERVNFSIVEGVLALLADSHLPATFWDEAAAYFVYCKNRCSHSALAKQTPQFVWNGQRTTTTVLHPFGCAAWLTVAPDLRSKLDPKAARVIFTGYDLASKAFRFFDHSTNKVVLGRNATFLDDDFPGLPVNMPVDADDTERQFVIPADAPAPDPADTHAPAATPAPAVKTRTPLVRSAHMDVSSPLDDSAMSAVDVAPGYTGGSLLNSTDTSPSSSPSLAPISSPATSSAGGPSIEDSDDPLDLLHSDTAVRLSLMDVHRSDDDTLVTPTPAVGPGQPSDDDSPDEIDFLSRHHRAFIATDDDNPTLEAIEPVKSITSDPQTWREAMSSDEHDLWAQAASDKFTAMRDDFKVFTIEPRSSVPPGATIVTSKFVWKTKRNAQGDITGRKARLVAQGNRQRNGIDFSETFTPVARFSSIHCLLALAAANGYHVHQADIDKAYLHGELDHDIWMTTPRGFDFPSDQVLRLRRSIYGLKQAGRIWNRHIDTSLRSLGYTATGTDHCIYSRIDDQKQPHYIALYVDDLLIVSPALDEIERVISGLEQRYGVKRLGPAEYILGIQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NI23</accession>
    <name>A0A2X0NI23_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C042g11997 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C042g11997</name>
        <name evidence="2" type="ORF">BQ5605_C042G11997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000116">
        <property type="protein sequence ID" value="SGZ31783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NI23"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ31783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="609" mass="69121" checksum="E6B526534CE0DCE8" modified="2018-09-12" version="1">MSPVKQKKKTRILVDFVRGGKRRSCHGKDVVFTPRFKGGLGGLARAAIVRAHPAPDFDLATDAWPCDYTPIRTDLHPRWQAVLKVPSTHNAQVKPRTLTLANLLALPIKLHTLHYLPGAPAVSRSPYDADYAAFANYAKVADLLRRELYPGGGFHLWTPPTDVVVSNSEYDQRGRPQREHIVAWYRHAINRLRFTPIAQPVAAVRINGPPRVRPRSEVRPTTPLESILPHPIDPPQRLPRPALPDQSTQYNLLSMDRPYTIRRVRRVLNAKAFTDTIGFRDSLQPDDLKGFWKGVNSKALTAREREVWFKLVRNFTPSRSLQFHQKHDDSPACLVCGAPKDDREHYFFDCVDSGNVWIAARSVLCDALGLDTIDNTHYTAVQRMFGLPKLKASLRDQEGAGRTIEIFTGLVLEMISSGRWGMQKWGTRMEGVVRRRIILEERSFWKAVNSKALTAREREVWFKLILRFTPTRKLQHQQNHDTSPACLVCEAPVDDTDHYFFGCVDSRNVWIAARGVLCDALGCDTIEDAQYTTLQRLFGLPKLKAKLSEQEGAGRTIEIFPGMVLEMISSGRWRIQKHGTRMESVERRRVVLEERMKLRAGGARGGRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NLE0</accession>
    <name>A0A2X0NLE0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C011g06454 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C011g06454</name>
        <name evidence="2" type="ORF">BQ5605_C011G06454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NLE0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY12282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="206" mass="22395" checksum="7E9ABD5E0AB18390" modified="2018-09-12" version="1">MSQPARGDSDDIGGMASTPPPPPSSSTSNQPFDVAPATVVTLTKEQYDALVKNQRPAQAQEDDAISMRHLLPPVNPPAFPDDSKLTEDNYVDWDLAMSTTYAREVCAYLCKGQHDPSWPPAFHTRWEDYAARALASSLTVTTKATIGPLIQTGGSAHDCWLALAARYAPSDAQAYSTLIKDYFSMPPCPHTWSGFHACVRVEVAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NSJ2</accession>
    <name>A0A2X0NSJ2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">BQ5605_C011g06299</name>
        <name evidence="17" type="ORF">BQ5605_C011G06299</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="2"/>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY11864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000007">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08284">
        <property type="entry name" value="RVP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="11" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="15">
        <location>
            <begin position="265"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="16">
        <location>
            <begin position="809"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="14">
        <location>
            <begin position="1122"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1212"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1228"/>
            <end position="1248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="SGY11864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1917" mass="215892" checksum="2FC76F0E52314E65" modified="2018-09-12" version="1">MAEQSEDDLSTDEENEYAPQFISTIPITLHNGKGSQMLHALADSGASSSFIADKVVEKLGLAVHRLPVPTMVKTAIKGQKRAFHVTSYVKILIALENGTWEAGDTILKVAKLQEPLEVVLGFNFLAKHKFNIDFARHEILVPHPSMPNVMIDLLAPVFGPQPQRAVPRSPKRSDKARINWGAVIAYIDGVQQKESELAELRAREARLRVEFADRFPGDIPPVLMYESPVQHRIELKPGAKKPNLKGYRAPHRYRAPWKRLIDQHVTAGRLRKSSSEFASPAFVIPKKGMDKDPSIQPQMVCDYRVLNEGTVCNRTPLPLPDEILSICSKARFWGKIDMTNSFFQTKMAEEDIPKTAVITPWGLFEWTVMPMGLCNAPATHQRRVNEALGDLIGNVCFVYLDDITIFADTLEEHERRVRLVLDALRRANLYVSPKKTELFAAECFFLGHQITRKGIKVDPDKVQRIQQWPRPTTVRQLRGFLGLVQYLRKFIDKLADLTAVLVPLTRKGAHVNDSWTGEHNTAFEAIKALVGSLPSLHPIDHSEQGDPLWLMTDGSNRGIGAALSQGKVWQTAMPAGYWSRQYNPAEGNYAAHEMELLAIVEALHHWRADLLGVRFKILTDHHSLAGFMKQPSLSRRQARWTERLADYDFEIVYVRGPENTVADALSCYSFPEDCATRGASDNVNMLAEATLDPAFLKALKDGYLNDTNCQQAIKNIDSTPGYSYKDGIARFEGRILLPKTGDFRENAIHDAHDATGHFGLHKTYKRLRRDFIWLGMKESCKEYVESCSVCQTMKMHGTGFAGRIHNLNVPDRPMREVGLDFVGPLIPSNGNDALLTVTDRLSGYVRIIPCRTTDDATTTADRFFDGWHQYFGMPRVLVSDRDKLFTSEFWRAYTGRMGTKLAMSTAFHPQTDGRSERTNRTVIQVLRTMVNRRQNDWSKHLATVEFVINSSVNRSTGKTPFEVVLGFTPELTPIAPVYDSTVSQAVESIMEQRETAVAEARDTLAIAKIRQADQSNKVRKLEPEFAVGNRVLVDSRDRRLRYKADGEARSAKFFPRFDGPYEVLAARPETLNYKLKLNAGDKSHNIFHASKLQHWTDNDGAAFPGREATEPASVVVQGNEEWEVDRIVDEKGKGKRKRYLVKWKGWADSDNTWEPQAHLEETIVLEEEFGSGGGECKARAPGPYEKGARAWTLLVSPQRLTRVSRLLSQIEQERSPTWTRSNKKRTQQLRPNPEDSQAFQRQTTTNDPLHQKLEEGIDSRREQSCAFQFCSEGFEPEHDGSVASGDDPSTIDFSRSETHRSFIQSTIKEEVGKGWLSAGTSFPIPGATYSSVFVVKSTNHRMRVVADHTRSGLNDGISRAACPTVYDTIIDLIQLLRWHRFASKLLTPNLVLWKLNVSSAFKVLVMSKNWQARQGIAIKRWLPDGELVTWYHIKWRGSYGIKYPLAYMDDTFGVYISNTLVPFVHNGVQHMIPLQQAQMADLWQSLGLPFKLSPGKAPFGRRVTITGIDCDLDDFSISLTPKAINDLATVIQAFLDFPGRCPPLRQWRQMTGWLSWALNVAPQARPHVTPLYNKIDSKTQANAGVPLNLEVRELLTSITRLLAATPRLDLNTTSLTRWSIDDAHLVIYTDACLQNDDHTGAGLGFWLTLPRGCHYFATCPGRMFERIQFVEALTVVIALDIATLGAFGSFWRVLVRTDSAPAVYALDLGACSDTPFLPLRAFTISAARRFDLKFSDELVLRVLKPCTRSDYQRSLCQWLTYVQVQNDIGFDISGHPTVSTLRAFIAHHYCSVTAVHQTLSGLAHFLGPIMGSTWEEVRSDCLVWAAIVGGQKLWRHALVQAKPLPFEMVNSLLDRALSDPLLDYNRLCFLAMLALGFCHEPVILQFLARFTGGWPYIVPSCPLLSEWILYLFEVSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NU11</accession>
    <name>A0A2X0NU11_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C010g05936 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C010g05936</name>
        <name evidence="3" type="ORF">BQ5605_C010G05936</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NU11"/>
    <dbReference type="STRING" id="796604.A0A2X0NU11"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904802">
        <property type="term" value="P:RITS complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013243">
        <property type="entry name" value="SCA7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037804">
        <property type="entry name" value="SGF73"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47805">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47805:SF1">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08313">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51505">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCA7" evidence="2">
        <location>
            <begin position="223"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY13664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="442" mass="45505" checksum="71CFD957C304B852" modified="2018-09-12" version="1">MKLKLRDIGDVPASASASHLHDNNTNNTPIKNNAAATSGAGHHSQQNVAPDGTGAADPNQGDQWAKIRQALRADPNSNGDTTQLSAQLLPLLDANNIIACPDCAKPILQSALEHHKVNCAEIRRRETMKRAAEDAPTSSSSSSAKKPKAGGLVIVLGGGSAGGAGPSASTTPEDPKSAAPNPKKKTSFVLKGNEARSPSVGPSSNNNGASTAAAAAAAAKAKASRAGGPVDVDRQCGVINDKGLQCLRSLTCKTHSMGAKRSVPHRSQPYDVLLHEWQRANKPNFKNDKPVQARVGPGAEGSVEAATGTSATGEPEVVAVAVANPKKKKKKGSGEGKEKKNREGSSKKGAVQMVGEYLDESEGEQIAAAMGTNHDEAVMIDSDEEVEGVFKVLGRVPRGRPLTMVSGGGAGFSAASMFVGRNSKLAKLGDVLGSVFSFTPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NUY5</accession>
    <name>A0A2X0NUY5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C012g06760 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C012g06760</name>
        <name evidence="9" type="ORF">BQ5605_C012G06760</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NUY5"/>
    <dbReference type="STRING" id="796604.A0A2X0NUY5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000013">
        <property type="entry name" value="pre-mRNA-processing protein 40A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039726">
        <property type="entry name" value="Prp40-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864">
        <property type="entry name" value="PRE-MRNA-PROCESSING PROTEIN PRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864:SF0">
        <property type="entry name" value="PRP40 PRE-MRNA PROCESSING FACTOR 40 HOMOLOG A (YEAST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01846">
        <property type="entry name" value="FF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25432">
        <property type="entry name" value="FF_PRPF40A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00441">
        <property type="entry name" value="FF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51676">
        <property type="entry name" value="FF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WW" evidence="7">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="7">
        <location>
            <begin position="77"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="8">
        <location>
            <begin position="475"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="8">
        <location>
            <begin position="605"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="193"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="671"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="225"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="671"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="733"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY16103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="827" mass="95017" checksum="CE92FE17DB9F4A7E" modified="2018-09-12" version="1">MSVPPTPQSPVAALASPAPGAASPLQGQQPAGAAPAAGGGFWTKAISPDGRPFYNHSITKESVWEKPSELKTPAELEAEKTPWKEYEANGRPYWVHAETKETTWTIPAVIQDILNRYSTNSPIPPLPHSPLPPQPALSSMSPRHLGNPNFQPGQMPMRPPMNQMSPPHPQVSGPPLVGGGALVGPGGFVPSGANAMSPDPTHRNNHHNNHNHHNNHNHHNHNQNHRGDRHDERDRSHDRFGHDGIPRFRHFHDAEAAFMDMLSAFKVDASWTWEQVMKETIIDPYYKALKTLTERKAAFEKYLVKTVEREKEEREASLERCRKEWGRVLEKLNGGTMMENGVKSWWSFERAKKELENKASDVWGMPRNDEERKALFKEFIEALKEKEETMRKEVRTKNLEKLTSILRSLNLELAGPLRWQDARSTIVRTPEWHRDPELQKVDPIDILQVFEEQVKIAEKEAIEGRARQVNDKKRRARKARDGFKELLYELKESGHIVSGTTWHSIHPVIENDPRYLELVGQTGSSPLELFWDLIDELDQVIEEHQRMIETILSERKSKIEEPTTYEQFRSMIDGDERVHKIDQEIVRVTYEKLHTRVVRQNKEERRKAERKVRILADDLKYAYKKLDPPVELGATYEELLPRIQNTPEFIALTDEAQRRLAYEKFMRRLKEKMQEREGSGETSRHEGERARGGHESRERERDRERDHGSRSSRHERTRRESSARDTSEGPPLQASSTTTRTFSANKRIAGAEHDGEDARKAKQVKLEKSSCGKRMDAVMVSPRRQKRCVGVPDARWAADFGAIHNTTLKMRRHSIISFWLPTDGRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NWC1</accession>
    <name>A0A2X0NWC1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C002g01454 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C002g01454</name>
        <name evidence="3" type="ORF">BQ5605_C002G01454</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY33132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NWC1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019412">
        <property type="entry name" value="IML2/TPR_39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10300">
        <property type="entry name" value="Iml2-TPR_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="794"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="10"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY33132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="859" mass="94167" checksum="E9858A7E4360A1E9" modified="2018-09-12" version="1">MPLLKRNKSRSVSSSSSVGGTSDTSSATSASLLSASSRGGKVKASDLTASFAGSASPNSRLLSLENDRSGGGASLSRSLSNKSNGGAGAARLPKPAVTSESEEEDSASEHNSEESEDDAPKRGAALRGKTTFGSAKSNNIKRSTSKAGNENDDEYAEEVSTDDEYAHPVKGAPVAAGTNSYDSDDSDAPPKRAAEPQKRGPSQRNKVNSSEAKNPAKRQNMSRAAKLATEAMEKDVKLRPKLGKPLSSLTSDDVALQESDVKEDIATVWKAMHLFMSSRMIEAEDICLAACDNRLYYAVGYALIQSIKSLATFEPEDLEAAISCCKDSILIAQLLRKKDHGLFENVGRLAKGSTSVSSIKAMTPVQRHAELVFSECTLLKGSIAVLGIIYSGDFVAFLKEALNMRNAYAIYRTLAAYVEAMDQSAGGHDDSIDEDFRSGVYLGNGLISLILSLLPSAVLKIMTVFGFTGDREYALKTLMLGGRWKPRTAEPGMPPEQEGIRRPICDMVLLMHHLVIANYLPVGGVDVPTAAHILHYNLDRYPNGIFFLYFAGRLHSTETQLESAVKSFHLAIAAQREYIQLGHICYWDLGLVSLASGDWIKGYECFNILDKESNWSKAIYAYAKATSIYEQGQDIAKANKIMKGVPDLMQRIAGKSIPLEKFVARRSRKYVAQGNRLCLPGIELAYVLNCLGLSPRFNLFEVHLDQISTVLSDLHQVKDPSRYGNGDEFWDDYCLAHLLRGIVLHFIAHPQPHVDPRPRKSQIPVKEADEQALISFNNVLKHGRDLQHDHHLVWFTHYELGRLYDSMGQFSKAREHFEKVMSGKNLELSLKKTKGKVSLQNMAVLRSNSALSLLKERGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P005</accession>
    <name>A0A2X0P005_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00371 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00371</name>
        <name evidence="2" type="ORF">BQ5605_C001G00371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY46016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P005"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY46016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="88" mass="9848" checksum="FC46B20E474D90D9" modified="2018-09-12" version="1">MPLVDCRNDTDTAGAPHHVTNASPRLARQAELCCRSNIMQSHALAAGAADTTVCCERHEIALEPHWFRVQTERIKRCNSQAKKDYSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P042</accession>
    <name>A0A2X0P042_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C019g08983 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C019g08983</name>
        <name evidence="1" type="ORF">BQ5605_C019G08983</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY23797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P042"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY23797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="389" mass="43187" checksum="E22FD9086A8069E4" modified="2018-09-12" version="1">MYQHTVVSAAPACGVHVPIRSHVQALWSPGTQGGPSQPRQVLGARIAPYHGLPWACSSARCWAPRGSTLLFVPHRSTESAPRRVMTTMQPILALRHVYEPAAQLRVHRARIALKPLKPHVSIRDDLGPQTAVCTHCKARHWECERSKSTRHFGACCSQGKVRLPPPPQPNLEYRQLLQGSDSAVAFRENARSYNNALSFTSLAALWDQTQVGTLGPPVFRVFGRLYHRLGALIPAVNQCPAFAQTWLINPAEATDTRLEPDGADSHMQRSTLTKLESMLRTKNHFVREFASAKPRAGWDTAKEWILRLCLPPGRDRRAHNPPTSSTEMAMLICDSDTNTGDRGPQDLILQVHGDRCPDGRPKYQIGKMASTPTFLFAGFHQARPPIARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P189</accession>
    <name>A0A2X0P189_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g03797 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g03797</name>
        <name evidence="1" type="ORF">BQ5605_C006G03797</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY53747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P189"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY53747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="307" mass="33965" checksum="3D884B7839FDFD4D" modified="2018-09-12" version="1">MLMLQYQDEQIWFALSTSVRYKVARSHYRSKFDVAAAFEQVCVIPEHVDRTWFATVTGTYTSRASLGWGLRRRARVLPLCEKSTLHSAQDLGARNELGALAQDLGAWSEPGALAQPRGSLAEDLGRAALLLDEGEAKNRQEARAGIGPVAGEIASALSQLRASKSPAQGGRLAGARNDRGVTLRQLLKRCCLIMLNFILLQAFQHFNLGRPFSPRRFSRLGRLSQLPPPTSWTTGNTEHCPSMNPPPVFVVQHDTSQPRWPTKSSVLCASQCDWPACYNSPAHLPDRTVSIPCLLMPFFLFSTASQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P1V2</accession>
    <name>A0A2X0P1V2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01469 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01469</name>
        <name evidence="2" type="ORF">BQ5605_C002G01469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY33239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P1V2"/>
    <dbReference type="STRING" id="796604.A0A2X0P1V2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="985"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1041"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="985"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1002"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1052"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1075"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1099"/>
            <end position="1111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY33239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1111" mass="124378" checksum="89F793549E9A2BA0" modified="2018-09-12" version="1">MARGLGQLANEIDLLLGILRRAPTIVTHSNTFSDLHQTMGRHKWNRFKFRPDYFEGHPDYKPRRLRSDPQLRTNIPGTRHMVTYTARQIQQRTFNEHARGEASSPSPRPPMAPPIQADFDEAANPSGMDWDDERHSEYGGGYERDFSPAPYFPDRTSHIPIAPDYSATAERLSLADLRQDESFEPATRGQSKQETYKQFVFNDSRLRRLERPALLRQYIAFCAGVKGHLRPLIDVDEELCQGSVASEVPPPCSCESPLTLLLDVSSSDSPCLTYAERLAQIGLIGSTAAAPRSAFTFRLVQFLDSWWSTAPFPVDGAARGLDIFYEQTGWGRPGLSQHKFDKELRKQLQRALDEFRALTTSERELGDLVLGVAGSLSDKCPACYGSTRLNQAHHRVEVQHLVALDGNFQHSRDTSAKYDFQESTPALFIGEGELESMKEICDGGDSKKSEKACADSWKAANGGATQISRGKSDTGLVACVCRHDIALKMVNLYQSGEKRYYGLSLLQHISNQLPSNDTLGVLYDVACNLDGYMQSRSILPDLFPRLKFATSVFHAFAHQWPCQLEYNPRLIQHFGLTDGEGCERVWSQLRSLIPINCPASASHRRVNSSRRIDLMNKNGVDSLGMLCHPHFHAVAQTDLSDVSAIWSESDLLAQWDLQRAAQAATTAGQRRENEDKERLELFNIVQRLHHVEERLFDPMASDEAKARLQQQLRAYQQEYDRTKELAASDFQHLCNCVVKLRALHKATVQLQCCQERIDSMGRGRSGATIGQVEASKLVSVSQTHSKKVKVAIDMYNKAVGDYRNAATEQSAQILDNLPLATTIKSLVTLSPTDAFWQDGFFVHDTAPWAIDTDVQKGIKAVLLKARAEEEILRIGAEVRQLLAWLEDEDTRFVRVSQAWAEDRVPEETIKAAKKLLGTDGAGEVGTAVWHVLQRRQISFKERLDRLAERDDLSVVWLRTRSPAVHESRPSAFGLIGGLFAGRAKQVSRRSRGSPRHFGRRLSTLNNTQMQSPIAESSRSLSGPSAVDVRHTPIDLDAFRRELGLTPDPAAEQAERDRDDVYERRMEEILGSLSEQEVEEEDDAELGEGGGESGSTRGEDSDDLEILDEPMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P344</accession>
    <name>A0A2X0P344_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C007g04618 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C007g04618</name>
        <name evidence="3" type="ORF">BQ5605_C007G04618</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY61887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P344"/>
    <dbReference type="STRING" id="796604.A0A2X0P344"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14944">
        <property type="entry name" value="TRAPPC6A_Trs33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037992">
        <property type="entry name" value="TRAPPC6/Trs33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817:SF0">
        <property type="entry name" value="GEO08327P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY61887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="290" mass="31447" checksum="077BABDBD06EC35D" modified="2018-09-12" version="1">MASRSRALGSLQHNTSSTTNVNLSSTSLITPQLTALADPPPTMVDQHLFEYMMQEVIRTIITSESVARERRIAYERQVEHDLKLARATSSITLNTSNGNGKTSAAMAPSVPSKSSTFPPPNQDEADEAVRSRLDKMGFKVGWAMAEKLARDRPRFPSTPATTSTTTNPVGASVLSLAPIPDPLEAVKFICKDLWIALYDKQIDNLRTNHRGVYVLHDNGLKPLLRLSGNPGPGQAHELNRRVKFFLAFPNGIIRGALSNLGVPCAVSAESAGIPQCTSSTFQIKTVRPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PCS6</accession>
    <name>A0A2X0PCS6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="8">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C005g03528</name>
        <name evidence="10" type="ORF">BQ5605_C005G03528</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="8"/>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY76894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PCS6"/>
    <dbReference type="STRING" id="796604.A0A2X0PCS6"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000050">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF35">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="9">
        <location>
            <begin position="32"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY76894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="512" mass="56130" checksum="DB9581F0C8086311" modified="2018-09-12" version="1">MAAVQKGDFVTSLTGTLCVPLHQQNVDLYTPLAEFDPEVQKLVDRETFRQFRGLELIASENLTSLAVMEANGSMFTNKYSEGLPGARYYGGNEVVDELEILCQKRALTAFHLDEKTWGVNVQPYSGSTANFATFTALIQPQDRIMGLGLADGGHLTHGAFTPKRNISASSIYFQSMPYRVDPETGLIDYDELEKNATEFKPRILICGASAYPRDFDFARLRKIADINGSYLMMDMAHVSGLVAAQVLNDPFEYCDVVTTTTHKTLRGPRAGLIFFRKDKESDMEKRINDAVFPACQGGPHNNTIAGIAVTLKQVASPEFLAYAKQIVANTKAIAAKLLEHDYKLQTNGSDNHLVLWDLRPIGLTGSKIEKICDLAHITLNKNSVPGDKSATVPGGVRVGTNALTSRSMKEPEMEVVAEFLHRAVQIAVSTIPRSFVSNVLRLTHSNHGGSAQLSAQKECGSKLLKDFVKTVTEGEGESRKALQQLAKDVNEFAEKFPLPGVPDSSSIKRVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PCV5</accession>
    <name>A0A2X0PCV5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C005g03558 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C005g03558</name>
        <name evidence="2" type="ORF">BQ5605_C005G03558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PCV5"/>
    <dbReference type="STRING" id="796604.A0A2X0PCV5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF19">
        <property type="entry name" value="MITOCHONDRIAL AMIDOXIME REDUCING COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141673">
        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="138"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY77110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="352" mass="40273" checksum="11D6D6F5D5402D0B" modified="2018-09-12" version="1">MVEKRIVVTDLWIFPIKSCKGTQLKESGYSETGLDASRRRFHYFYDRQWMIVEERSHRFLTARNIPRVSLWEMVLIHPKINSTTLQVDVPAWGDSPSSSHWIPLDLPSSITDEDLLTDVQIWGSSNTAYSVGTPELNAALSGFMGKPVLLVRKGDEPRLTAGGEIVETLSEVKMDYEGGSTIKWSDQFPVLLVSEASRRDVEKHVLKQGYGKENQRWSERGIQEQPLEILRWRGNVIVDGADAWEEDGWNEIRFEGREQSETMNVATRCARCMLPNVDPETGVRDKSVPDKPLRLFREGIWPIFAQKTFFGVNLVPRTARGTLRVGDQVVVVKAFSPKDDHEHQYERPEDQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PD34</accession>
    <name>A0A2X0PD34_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C005g03648 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C005g03648</name>
        <name evidence="3" type="ORF">BQ5605_C005G03648</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0PD34"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015981471" evidence="2">
        <location>
            <begin position="28"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1337"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1533"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1580"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="671"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="707"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="728"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="764"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="785"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="821"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="842"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="878"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="899"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="935"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="956"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="981"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1011"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1042"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1069"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1108"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1174"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1206"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1348"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1547"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1588"/>
            <end position="1605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY77479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1614" mass="167937" checksum="55D7A6353739FBE5" modified="2018-09-12" version="1">MKLIRSARGAFLGAIGLSCLAVRLVRAQAGDEGNSYYADDTNSWIKFDGSWKEVVSDQFHQYTSMLTSDKGATATFKFIGESFKILGISDQANFSVTVDGQDADVPSVSSDPDKTSALFSQTQLRPGTQHTVILEVISSGNLSFDAVVIGGGPASKAALCPVKGHQPCTSVNFQSIPKAHQSKPSTDRGGLFTTSLLHAGIKLKLRKPDPDPSTPKDNSGDKSGNPLRHPKGAVGRKQKVDNTDKQDEKMGKDDVDQDGGKHQHQNEGKGAPKDQPTNDSADKEYDPGMKIGKTSEHHSKEDPAGADTTKSEKAGLEGHELKPSKQNKPDSPKTENPAPDDPKEPKETSAPHNQTDGAGGDSGLLEGLLGGAVGSSGSNEHESHHGGDHREGDSGSQTPKKSSLIPAIVKLVGSDGGHKPSKSKASSKPTDAGTLGNSSDPHKPSSSDHSTTLVGLSRPLGDGTGEEHHSNSKDSGIEQPEPKTLVDIKGGGDKHPDDPAADKPPPTPKKLVSIKGGPTDTGLQAGIDLPKIVLPGSPATKLPDGQDVLGKKNVTGPSKDPGGKDHDQDHPIVPVVIKFSDSHDDPGSVATVVTVSQEPVPKPSPGDSSASSASSNKTSGGTHGNPTKMIPDPTKDIDPKDTNPKDADPKDADPKDTLDPQKPMKGEHLGKNTSIVALEGPTSTGKDLGQNPGLERNSSSGALNTPKDTDPKDTLDPQKPMKGEHLGKNTSIVALEGPTSTGKDLGQNPGLERNSSSGALNTPKDTDPKDTLDPQKPMKGEHLGKNTSIVALEGPTSTGKDLGQNPGLERNSSSGALNTPKDTDPKDTLDPQKPMKGEHLGKNTSIVALEGPTSTGKDLGQNPGLERNSSSGALNTPKDTDPKDTLDPQKPMKGEHLGKNTSIVALEGPTSTGKDLGQNPGLERNSSSGALNTPKDTDPKDTLDPQKPMKGEHLGKNTSIVALEGPTSTGKDLGQNPGLERNSSSAASNITVGGITFSRLASKPDKDASTKVPDSKVPVVVKDLPTAVNKPNTTTNTPLPFDGRKPLVDHQPDAKSPEKTGQQGDKSAKSSVVSKSGMNSSNVVSTSGKNSSTVLVGAAGHRAGTKKPTPSTGPDPTLQQAGTEGQPLSTEDSTSHTTKPVLSLKSQDPPQPKTQEPTPVAATTEPSPAPVNQPSPITTPISDGEPGNSSASNPWSGVVQQVKNDGGNGGDGGGGGGGGGGGGGGGSSVDPKPDTETAPTPSGGDNKSDAPPVETKKGSWLNPTQPPSSLPLSKSHSKSSETGSPKHKFVLPETTTTTTTNHPGAIAGGLCGAMAGAGILFALLRYHSNRLHQKSILDEANRNARSPTPGPSRPSPPTFIAPSDITVQIASTHPYARTPTPPPIRPHPQVLNIKPNVGQPRPLPPTMTAEEMREIDRVIGRATGHVAQGSNASQATIRSTREIARPASDFKAPRSPPAPPVDTMPTTFPTDIDAAEEAADEEAAAALAASHIIRFDETADVAAPRASLPPVLPHIRPLSPDDVTLDIAFQSTHTTHPDSAIDVPTDASRDDPDDTPRDEVEREARERTVVVEIPIDSPLITRSQDATGWHKRELYPKYEPSRGDPRLWAAPSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PDG5</accession>
    <name>A0A2X0PDG5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C008g04959</name>
        <name evidence="10" type="ORF">BQ5605_C008G04959</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG7 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY78813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PDG5"/>
    <dbReference type="STRING" id="796604.A0A2X0PDG5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019335">
        <property type="entry name" value="COG7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21443">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21443:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10191">
        <property type="entry name" value="COG7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="401"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="401"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="447"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY78813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="997" mass="108130" checksum="9F9BFFED14D2E806" modified="2018-09-12" version="1">MSGDVAPAVPLASSSSLPALDLCRLADLDDAPTEAEWLNHLLKATMNHDRASQSSSQANLGSLEASLGKALAALEVATHDTSALVDRTIDDISRSVPRLAFDLQLMRENALLLRFTLDGIRKRSGTGSGFGENPEVSCVMEKLRVLDLAKARMEAARDVLREAESWSTLESEVAGLLGEQAFAKAAERLEEAARSMVVFQNTIEYEARRALMVSLQNQLEASLSSSLVSAINTRDVKTCKSYYAIFGQIQREAEFTAYYFGSRRSALVDAWVNAKLIDIPNVTIELDAASTATSTASASIMSASTPIKLTSFLIKFYGDLHALLAEERTYVPAIFPDPAPTISSFVSTTLEGLSPSLPQRLSAIADTYGPLILPELIQAYRATEDFALSVDQIISKLDPSSATPLATHGSSGSVSGAPFVSSPGLEGSAPATPSKRDRRLSKRMSTSRRMSSRSLSFGGSAVSNTDGAGVPTTANHAAVRAWETAMFEPFLDWQVEYPELERQYLAYEVARVTGPPGTNVMGNLVEEGAGASSGSRDQKGGEKGARALWDLTSSVFSLMEDAISRSSAMTHGYAAAGIVEVIDGQLVDFLDQRKNELNRAKSMVGHARRRQGLRSENEDEAAFEGLEYSTEDWGTFQLGLRLLDTCRSITDRLTSFENKLQTRLMILAQTIREAREDPLHYSIPGTTRGAITLLRQSALNSVELAQLLEPLERLQDALTGPPAPPLSLALMPKARFATVEFTRATQLFLHETILAPLLAHLNDYAVLPTWTTSQDQRPGAKGAFDLAIPTFSLSPTETISRVGEGLFNLPRLFEVYAGDDALAFSIETLPYVDAQALRALQPPSLASPISPAHRSSLSHSRMSESVSLSPPATSAFSRRVASVSLVSMPSSHSHLSAETVISTWLSSLTLSILHHLTSVVLPTMHRLSKHGARQLVSDLDYIVNVARALDVEASDELEAWRDAAALREKPGNEEELGMDKRVYERVAKMRGWRKTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PDY1</accession>
    <name>A0A2X0PDY1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C008g05149 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C008g05149</name>
        <name evidence="8" type="ORF">BQ5605_C008G05149</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PDY1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015882135" evidence="6">
        <location>
            <begin position="22"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="7">
        <location>
            <begin position="3"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="144"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="180"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="223"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY79497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="260" mass="25005" checksum="BD86C54BB1EA7FB3" modified="2018-09-12" version="1">MYASLHSLFFVALSAATMIAADGTPNGDGSNASIPLCGITCAQQVAPQTECKNLTNIPCQCSDSAYRSLILTCLDTQCSLSQDKQDAIDSGKKFCLDQGQCANGHPRMGRFGRWKAAIKLETEQWSCCFPSLYHIMASGFGTGQASNGSGPSVGGGPGQASNGSGPSVGGGPTHGNNITSGGGSASGSGGSGGSGASGSGGSGASGSGASGASGSSNGGSSMGGSSSDNGGKSSAGPSSKGAIRLVASLGAVAVAFAVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PE23</accession>
    <name>A0A2X0PE23_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C008g05199 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C008g05199</name>
        <name evidence="7" type="ORF">BQ5605_C008G05199</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PE23"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039868">
        <property type="entry name" value="ARMD3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013636">
        <property type="entry name" value="ARMH3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13608">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13608:SF3">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08427">
        <property type="entry name" value="ARMH3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01158">
        <property type="entry name" value="DUF1741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Armadillo-like helical" evidence="6">
        <location>
            <begin position="549"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="358"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="751"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="375"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="763"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY79688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="924" mass="100054" checksum="B142BB9A39BF4868" modified="2018-09-12" version="1">MSVPTLNLTLSSSSEAAATRTTPTPLGADTIIPPAASTSASTTPGTKGTPVPISPLKQVNAQQDAPPIRPKLESCWEQLTTNPTLFSERSIPQLHRYFNELFCLTPNPDTIEQALEALSVQDLLGEYKDNITYLFTHATRTLRETQTDHIIRSNITETLIPFLRNLLSRRYHNFSYDTINLLAGSLAHSDTVFTNLVSAIDHTLQDRNLATPLRHRTLQLALVLVASIDQGSINAYFLRRDLFSTLVQFMTEDATCQFSFESALLLGLLANYRQHEARNPYRVRIEDMVEETVMARVIEVVQVVCQQARDSYTHIADDAPASFVASITSLIFSFKVPDFFKQGLVFSLPPPPLLNRATSKASLRSESSATPAAKPKADGKVPVEAEGESKPTDVATKNSRTTPAATPDLVVSSAPSTAISKEKKEENQFKAMPNEVLVILLPFFDLIHLNKSFCAFVLADSPSGKRKALSVFFPCSLLTMRSFTAPALPSTLISLCSYVLCHASVSSRARSYARLCLLLIMVLVEEGEGKLSKATDEIWICRQRIPMLSRSTGKRPALAAMLDCCVIFLRHNLRQKLDVETFIVCLRLIQRILQQLKTERIRLAYDWVTVWRSILSLAGFVVSQIEILRLVSTQTDDLISQIFILLSYAAYWGETLFPTSEDAALLFYELLHADETLKALSDLLGVSSIPLPPSSFSASSDDAGSRRSSSSVFANPRTLAAIQATPLMRPSPLMLDPTTFFGGYVTGDSGSGNGSGLKPPGPSNNASTTASGTSGSSSTASSAEPTDASQSHLAKGFIATECVSNLHLARAHFINSLEAFKQGPLSPLGKGEDPTLDPETIVAVIEDNLGGLELIESSAMGDMRKGIANMGGVVRTIPSVGAVAKGTGTTGVGANEEAGLSGAVGWERSMMIVVCKDALSILCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PE80</accession>
    <name>A0A2X0PE80_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C008g05259 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C008g05259</name>
        <name evidence="1" type="ORF">BQ5605_C008G05259</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PE80"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY79962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="135" mass="14903" checksum="F0D67568D9E76701" modified="2018-09-12" version="1">MCCLSCLLPATRQLLPLPPAGEVGTAVWYVLQRRQILVKELHESRPTAFGLIGGVFAGRAKQVLRRSRGSPRHFGRRLSTLNNTQIQSLVTESSRRSSGPSAVDVRHTTIDLDAFRRELGLTPESSRGACRAKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PEA7</accession>
    <name>A0A2X0PEA7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C008g05289 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C008g05289</name>
        <name evidence="4" type="ORF">BQ5605_C008G05289</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY80034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PEA7"/>
    <dbReference type="STRING" id="796604.A0A2X0PEA7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF10">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="3">
        <location>
            <begin position="8"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="235"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY80034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="275" mass="31579" checksum="5D2D3D07CA785866" modified="2018-09-12" version="1">MSTPLSFLETNRALEAFLEVAIHALLYTRNVYPTNIFKQHHKYNIPVWQSRSPLVNEYVSKMCRCVGEELDKRSLRKIILVIKDDGPAETPFERFVFDVEWLIHDDMLGKDARDFMSVRSTPASTKPAAGGITRTEMDETLRGFIVRVEAAKNYLPKLPKNVTFSVVLEMRDDVEPQSLQAKRGIEPSEWYRAEARHSAEEAQGLVSRLVPHQTTNLGMVQVQFLAEVLEKDPWASFESGEAETSTNESNEAPRRNREEDEQEKRRREKGKARAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PEW0</accession>
    <name>A0A2X0PEW0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C008g05338 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C008g05338</name>
        <name evidence="1" type="ORF">BQ5605_C008G05338</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY80253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PEW0"/>
    <dbReference type="STRING" id="796604.A0A2X0PEW0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY80253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="85" mass="9717" checksum="2600FDEF3B1DEB34" modified="2018-09-12" version="1">MMPRRHRTGSREVPGDLPLLEDLRSHSLDIGQRRNWDILEGMTLGRLGPDKKEEMLLAASYRGGGTETPNVDRYQPIIAMETCYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PFU8</accession>
    <name>A0A2X0PFU8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C009g05679 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C009g05679</name>
        <name evidence="4" type="ORF">BQ5605_C009G05679</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY84148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PFU8"/>
    <dbReference type="STRING" id="796604.A0A2X0PFU8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00027">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13561">
        <property type="entry name" value="DNA REPLICATION REGULATOR DPB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13561:SF20">
        <property type="entry name" value="DNA TOPOISOMERASE 2-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="84"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="196"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="541"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="784"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="327"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="436"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="487"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="730"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="899"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1042"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1118"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="439"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="918"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="972"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1053"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1066"/>
            <end position="1075"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY84148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1181" mass="128774" checksum="B509E427417C025F" modified="2018-09-12" version="1">MAFGFPSKKGVRTGMRQNNGAKRNTVKLRPPPAKAPTASSSRSAAEDDDNRTPYYQRDSTHQQYDQSDEQGDEEEFTYQDQLRGEKRPLEGATVTVSGCGADKRMLMTVAAELGAKDCTSLTSQTTHLIADGFGSAKCDMALKCNMKIMDPKWLLAVRDAWRDAENVDFAELEKKYRLPALTGTVVTLTQFPPGRSPAAPFSTLELSLEALTQLLHRSIGARESELMTILKGAGAEITKRLTRRTTHLIVSSTSSSHLPHTSKLEFAISDRGRTELPKMIIVWEGWLEDAIRRGGRTVARDIKWKYEPGGEAPIMLDDDDIDPIASTSHSRTRNVSTVPPTSQFQTSKSHWGPSSMAGGADHGTTAKKTGEETEDGNTVVIRKKKSRIDNDPLLGPMAIKLRTQGSSIRPGSGAMYRDEEADGELVAPHEMATQPLRGRGSEAKVDGPVERPSEQVTSATNDDNPYALGRDRGGSIIKALSSTRLRRFDEVEPSRPRTALVSKRSMEGHAPNPLAADDSAFFEGNEEAQMGAENEHGEDSSDPPIFEGLTFSLMDLQDKNRDIIKRAVEERRGKVLIDRIEPTTDHIVVDFFGAPREYLGPDADPRVITGCWIESCIHEDRLVPFDDRLLERPLPYEIPIQGADQLRIHLSGFSDIGKIHTKRFLKEIGAGTSKVFNRSCTHLIHVDAGKEVGGPGGLKIDKAREWGIPIEGPDWLRSWAAQRGVIPSASSAESATSRITRDKKGKGKATVAPRDITNESQPRLARARATPHVDTTVVDENQAITSGALSGCVIFVSNKLASVEKKKVIGSVTKLGATVATSFDPFVATHLVYASNRSNDPSSEYKKAKAAQTCIVHPQWAVECELLDERVNEHEYPHTFDPKRGGQLAIVAISSPAKSQERAQLVASPGGRRAGRPLNSQPLWMERSNSSPSKPATPKRHNVDMDDSFGPLAAAQPVHSDRADEPSSPRLSQAAEEAGAGARVESGSSSDPAPVPAGEDESFQETGRKKSGSTQQFDELTRTTSELLVHFADLGGELANPARALSRKRSHVSNASTKSSMSMSREGSKSSEVPRKVPGQAMFEPSQFTQAGEDTYAVEYDDPAEVAARAALAFALGEGKDPTTTTEAIEPAPVDQGSEDKEPYTRTSTRSSARKRKIDNDLTEEESFEFGKVGKRIRRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PG74</accession>
    <name>A0A2X0PG74_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">TBP-associated factor 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C026g10158</name>
        <name evidence="11" type="ORF">BQ5605_C026G10158</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ27661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PG74"/>
    <dbReference type="STRING" id="796604.A0A2X0PG74"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007900">
        <property type="entry name" value="TAF4_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05236">
        <property type="entry name" value="TAF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID component TAF4 C-terminal" evidence="10">
        <location>
            <begin position="98"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="115"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="297"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="415"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="304"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="445"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGZ27661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="525" mass="57091" checksum="5D7D41D23F098823" modified="2018-09-12" version="1">MPSASSAPPPSQSPATVSTPTASASVSTPKPGGGRTGGGLQLPGALGNKGKTKANPSAETSRNTTRDTLKEPHETTTNTNTTTGKFEHEPSTNVQHLMDAVGASGVDINAEEDSLRQHQPVGSHFNTTSTSQQPNPSTTHTHTHTHTHTATTAASSAPSTSTLTDLDLRIHSQSFIDPQVLADVVRKIAAEYSLKSLEGQTIPLIALACRTRLMDLISNSIRVRDHRLNANHLRKPPFDNQLKRRRRDQALGEEYRVHEEDDMLQEGKKEPVWDAVVYDEPEKALWVLEKVDREEERKRRRERVLRDEKEQEEKELREAVEASERAREEQERDDIGISTHGVDGTDQTTTNTLALTGNMETPKSNPLLKKKKKRDLGQAAIAKNLSGDVQKRLTDQIAMRSLGGRSFSWLSGAGGAAAGGSSMLTPNRPHNQSAIGTPTLGTTPSARSSSLNPFPSSLNRLTTIPSLHDANRQKLDAEETWRQGTHVVELKDILFALDNQRGMGLGKGAGKVASLKARAGVVRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PHN0</accession>
    <name>A0A2X0PHN0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C032g11088</name>
        <name evidence="13" type="ORF">BQ5605_C032G11088</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="FQNC01000067">
        <property type="protein sequence ID" value="SGZ04772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045358">
        <property type="entry name" value="Ty3_capsid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19259">
        <property type="entry name" value="Ty3_capsid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="11">
        <location>
            <begin position="715"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="12">
        <location>
            <begin position="1280"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="395"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1111"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1506"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="112"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="425"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1116"/>
            <end position="1129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGZ04772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1526" mass="172820" checksum="F6C365CB87F55932" modified="2018-09-12" version="1">MCIARLVVIQNFCVLTAPSYPYMCRHVAGNFLGASSYLYDLAPRSLPLASTCFHEFLSLSLGFPSTINRASYSYKNNYINPASRPVILAIACCLRLSNLNPDSRSKFTIDLVDLTQASLDSLIDQLRTLQARNQALEAECRSHLSDKENYQITVTALANQQQTLSDFAKAVVDQQKESIDVIKSGLANLNVTAPANTTITPVKSQLAKPDKYDGKEKVKFKTFITQIKFCIFGNPSSFPTDESKIAFIISHLTGDAFQHFEHAINAKDDSKPEWLTNYQKFLDQAELVLGDPDYRNNLTRQLMSLVQSGPASVYASKFTQISSQLDWNQAALIAHFHKGLKLDLQAQLALHNDPQDLQSLIELAIKVDNKLHLARHRTNASTQFRQTNWQYSHSVNSPLRTSPVSQLQANPSTANTSGPAPMDLDATRSRRGPLSEEEKLRRRTNRLCMWCASDQHLRAQCPTAPPMIPRHTALNASPRMSCTGTLFPQVSSPPSPRYSQQNSTRFPKTTLFCPSYSISSPHPDLATSFVHDNHLQLIAHPTPIPLYVIDGRPIQSGNIIHFVHLEVQFNGHTQSLRADVTQLGTYPLVLGMPWLRLHNPIIDWKRNTLVYSCQSCALGHTQPINVSIEGAPLVPLDHKHLDISFASSFAFERLVNNSDNHHGLLFYDPASHRLSSSIPAPSQSLSDDNQDSLEYLESLKNLVPPEYHHLLAAFSKVKADQLPPHRKFDLSIDLEDNTTPPFGPLYPLSETELQTLSSWLKENLTKNFIPCLHVARRCPRLVSLDRIRGANIYTKLDLRSGYNLVRIKEGDEWKTAFRTRYGHFECLVMPFGLTNAPAAFQHLMNSIFRDLLDVSVLVYLDDILIFSGDECQHTRHVQEVLQRLINNKLYCNPKKCEFNRASTEYLGFIISLSGVSMSQDKVKAITSWPTPTSLKELQQFFGFCNFYQRFIKGYSRVIAPLTRLLKKNTPFLLDSAALSSLDRLKQLFTSGAILCHFNPLLPSIIETDASDFAISGILSQVTDGHLRPVAFMSRKMLPAKQNYEIHDKELLAIVECIKIWRHYLESSQHPFKIYTDHAALQYFQTKRVLTRRQARWSETVNHHKYTIEYRSGPKNNKADTLSRRPDFSEGGKASEQPGQILLRPHTLAASLVKFSPPSDIADLIKFHLSQDPVSNQIVNDLNHDSTLHPYFKLQDNLLLHHDKIYIPNAEPLKVKLLAQAHDSLLSGHPGQVKTFELLNRNYTWPGMRQFVNNYVKTCDSCQRNKPTHHRKHGHLQPLPIPSKPGSSLSMDHIVDLPPSSGFDCVLVVVDRLTKEAHFIPTHKTDSSRDLARTFLTHVFKLHGLPTDIVSDRGATFTSNWWSEFLAMLKIKPNLSTAFHPESDGQTERTNQTLEHYLRHFCDYLQTNWSELLPLADFAYNNSFHSSIGASPFYVTRGYHPRLEVSLRDSFVTDVPKYLQHLRSVQETARKQILQAQETQARFANLKRKPSPPFKIGDQVLLNRKNIQTSRPSSKLDSHKLGPFRIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PJ84</accession>
    <name>A0A2X0PJ84_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C041g11980 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C041g11980</name>
        <name evidence="2" type="ORF">BQ5605_C041G11980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000119">
        <property type="protein sequence ID" value="SGZ33627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PJ84"/>
    <dbReference type="STRING" id="796604.A0A2X0PJ84"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF4">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="9"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ33627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="306" mass="35018" checksum="5C42A3F2A21026DC" modified="2018-09-12" version="1">MNPSPSPFPLFHIAPTPNSHLGAFASSPILKGTTVLLDTPLFTLDAPFQAYLYQRVQSGASGPTPIEGEEEEEGNVFPTLEEWFEKQIQRSLIDKTPTEINQFYTLSNMHPSQPRAYAIFLTNAVSLSESTTGGLFPLLSRFNSSCRPNLSRPHWSSKTRKMELIAVRDIEKGEELVWPYLGIPFEFDSPESRREQLKQIFGFDCACRACTEWTQPSIHNHADTTLAEPSPKLKASEARLRQLRRLKQMIDMGGERVLRKMQKISKEEGLWEMSDRLGFEANRVARGEERRGWDHDNLHEDEEKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PKQ1</accession>
    <name>A0A2X0PKQ1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C023g09629 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C023g09629</name>
        <name evidence="3" type="ORF">BQ5605_C023G09629</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ23747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PKQ1"/>
    <dbReference type="STRING" id="796604.A0A2X0PKQ1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016287">
        <property type="term" value="F:glycerone-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052744">
        <property type="entry name" value="GPAT/DAPAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605:SF0">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="784"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="838"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="871"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="954"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1002"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1057"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1002"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1078"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1096"/>
            <end position="1107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ23747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1107" mass="120121" checksum="99013867B2ADE4CD" modified="2018-09-12" version="1">MAKSKGKGTRAKSEPTPTPTSPPPNKLHTPTAAAVAAAPREDAERVGGDDGNMPTPTSTPTPGPTIGDARVSAVVDAVPTLEATNSAASQVEKNAMRGFKVPSGMTVPLDREQEQEKEQEQASVVEDEPSAAKLDPTTTSTTSSSSSATELAAAPPQAHADVEPEPSAVTATAVAAAPSTTITTTTTPTPTPTSFSSSPSTTRTLKHLTFDDSVTFAPASRQLPTSSSNLSTSPERTSRSAARRGSSSLSSPSKTNHPVASTSPAPHPNTSASTSTSTSPRRSSSSSPPPPTSPNKKRASLTHTRQDLRQVLKVLIVVVPSSLRRLLRLLVPPPLRRFASFLLSRIAMVLHRRGALASSMFYDLMVLFWKTLINIFFREIRSRGAWKVPKAGEGAVIFVVGPHHNQFLDPLLLMSEVRREAGRRISFLVAAKSMDRKFIGQVARLMQSSEHIVTFSELALLYRDLRRTFPNLATVPVARAQDLATPGKGTITLSPDDPTVVIGHGATEFMKSFAQARSQIMLPRSLGSVSVEIAEVMDDHKLRLKKEFNKKVRDGWMDKGAEGVAYKVLPYVDQSKMYSSVYQKLTEGGCIGIFPEGGSHDRTDLLPLKAGVSIMALGALSADPNLRLQIVPVGLSYFHPHKFRSRAVVEFGTPIDIPSDSVRAFERGGDDKKKAIGDVMDLVVDGLKSVTVRAPDFETLMLIQATRRLYRPPGQHLTLGQIVELNKRFIAGYEAYRDDPRLKQLMIRVKEYNTLLRYMGLKDHQIERVVRPFWRSLVLLCYRLGLFGAWSILALPGVILNAPIFIAAKIISHRKAKEALAASTVKIKGKDVLATWKVLVALTGAPTLYTFYAIGAAVLARRLNLGYKYQLYAPLATLVGLPLIGISALKFGEVGMDVYKSIRPLLLSVLPGNHKQLDKLRAMRSSLQIEINQLVEELAPKIFEDFQTNRVVQPSAKPAPVSEHATKRRSSYGPQGQGTFLTHPLSWVDEYLFGWSAGGRGGEGRDMGHESDEGAKSGNEDEGGRRSGYASGYASGYTTEDPDYDEVINILSREQGHVSTVDGAASDAGTAISASSGMRKRRGSRSRSRSQLDLTALDKIEERGKHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PLI6</accession>
    <name>A0A2X0PLI6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C023g09618</name>
        <name evidence="9" type="ORF">BQ5605_C023G09618</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ23670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PLI6"/>
    <dbReference type="STRING" id="796604.A0A2X0PLI6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1900:FF:000011">
        <property type="entry name" value="Spindle pole body component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF13">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="256"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="362"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="653"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="94"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="191"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGZ23670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1000" mass="112560" checksum="ADD40458915294A8" modified="2018-09-12" version="1">MDGPALPRRSDSRQSSRSQSQSQLHASSKPLHPAPHTRVGSSSARASSVVSGAYASASTTLFPKTPKSSAAKYGGLGEKELQQITSSIRTAVKTTGSYKSRTMPVPEEFDASLAQDPIRDPTPSGSFVAETSFSRAPLNSRLPPMSPHRVALASASRRKSSKTTTTGAKRHSSTAARETIESNAPPATADYSDEDSLNEDSEGLDEFEPADELETRQREGLDPEPLQGLSPELQEALIVEDLFFVLTVGPTRQDSLGIEGQYIEYDPTYTPEDEFERLYGSRFVLAPSLELWMAATVTRFLDIAKHYTSIHAFIEQYSILEYGVINHALCAAIREMLKVKALQLNCLRPNVHRLTNIPLRFRLQEYLILLAQLEHQFLNSPGFTLQRFWFYLHPTLHTLSLINSLTLDLVALSIPPEEVSSSEESGDSDSFVGNAALRDVLADMEGAVKSAAKADRASRGEGIAKGGEVLFVLSEKLDRTAGDPAARELYTTLLLRASQPYATILLGWISTGHLSDPWDEFIVREDKKQTRESIETDFTNDYWEKRYKLRDNLSSDGPAEPVVNRNIPPRERGLSGGQIVPRFLEPWKEKVLLAGKYLNVLRECGIDIESASGDWAKGQLLTLNDESFFRRINEAYTYANKALLKLLLEQEHLLTRLRSLKQYFFIDHGDAFTHFLDLASLELHKSRHSASDEKLQSLFELALRNPCSASAADPFKDDLIVVLAKKTLTEMLVKILKEDGKLVDASEGKKNARDKEDDKKDKNFLAHQAITLEYHAKFPLSLVISRNTITHYQFLFRHLLQLKHTERVLAEMWTELAKSPSWRVRSPYPELEQWKQRVFGLRARMFAFVQQMYSFTVSEVLDVNWAVLERKLAKVETVDQLLSDHVDFLATCLKECSMTNEKLLVIHSKLLEVCTRFPPYVAKFTDAIEMSLASAERHSKDWSQVGFKKQWDTLASFEQHFNHHTKANLDRLSFHATKENPALLPLVVRLSNLKVPSLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PPJ4</accession>
    <name>A0A2X0PPJ4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C041g11965 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C041g11965</name>
        <name evidence="2" type="ORF">BQ5605_C041G11965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000119">
        <property type="protein sequence ID" value="SGZ33439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PPJ4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ33439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="96" mass="10304" checksum="418220CFEBB98CC8" modified="2018-09-12" version="1">MRLRVRANESRSNRDAQASCIGGDPTLSKVYPSSSTEVYPSLSSEVLPHPVSSVKKSTASTVPHCSRRLTQSTPSQLPPWKGTTSPPHPKQSSSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LQI6</accession>
    <name>A0A2X0LQI6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FK506-binding protein</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C010g06120</name>
        <name evidence="10" type="ORF">BQ5605_C010G06120</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FKBP-type PPIase family. FKBP3/4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LQI6"/>
    <dbReference type="STRING" id="796604.A0A2X0LQI6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.340">
        <property type="entry name" value="Nucleoplasmin core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041232">
        <property type="entry name" value="NPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023566">
        <property type="entry name" value="PPIase_Fpr3/Fpr4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811:SF19">
        <property type="entry name" value="39 KDA FK506-BINDING NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811">
        <property type="entry name" value="FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17800">
        <property type="entry name" value="NPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001473">
        <property type="entry name" value="FK506-bp_FPR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0697">Rotamase</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016033310" description="FK506-binding protein" evidence="8">
        <location>
            <begin position="21"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="9">
        <location>
            <begin position="311"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="54"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="143"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="182"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="262"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY14254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="397" mass="42730" checksum="F0387AB88D33DBA8" modified="2018-09-12" version="1">MSLILGLCLVPFSTFRSVTLEPGKTYSQNTTPAIQITNISFGAEVKGDARTVVSMKYPDWDPEDSDEEEEEEDKDEDEDDENPVELPKLITKETVLAVLKPNGTEQVQVNINLVEDVEVVEFSITGPNPVHLLGHYIRQEDFDQDPYSDSEYDSNDESIPSDLEDDENEDDESDLEGLSGLIDDDSGDEDSEDEEMDESRFEEIAQPKAKSNKRAAEAAPDAGDESVSSTLSKNQKKKLAKKLKGADGAAAPAPAPAAPAVKEVKPATTVEKKEASKKRCSSVEQSATQILAGGLQITDAKKGDGPVAKNGKKVGMRYIGKLENGKIFDSNTKGAPLVFTLGRGEVIKGWDQGVLGMAVGGERKLVIPAALAYGKKGTQGIPGNATLIFDVKLVSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LSN3</accession>
    <name>A0A2X0LSN3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C012g07045 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C012g07045</name>
        <name evidence="2" type="ORF">BQ5605_C012G07045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LSN3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33116:SF78">
        <property type="entry name" value="OS12G0587133 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33116">
        <property type="entry name" value="REVERSE TRANSCRIPTASE ZINC-BINDING DOMAIN-CONTAINING PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY16964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="599" mass="68085" checksum="DB20C8B7DE226BFF" modified="2018-09-12" version="1">MYRLNKKKNDAVVVVESPAALSKLETLSQTWYEATNGKTNTDKTLVLPLGPNWLRDETAQALPTVQEGESFKWCGYAFFRHGDSKLFWTHVLDRIKAKARAARDRTLSPSGRVFYANAHITSTVLHVLSFDIPPQWFIQAAETALTDFVWGGPRRNTVAREFVFQTREDGGLGLISIGDIVHSVALRFWDAVAGSDEAIWAPLARESWRSLVATTRDFSPWGFFSSTARVEKLYRDSTRWGAVVAAARVTVPTIKSELLTLPELLSLPPRLPSLYAEGAKHAYDDADAVAKFAQIADLYWRDEGKGWALVGHRRGFWQHSKEPALRHEHVWARVGQKLKAKALLPKTAVRPARIPLKEDPHPRCFNFFGLTRPFTIRKLRRLVNKVRFPGKDGQDRALPGGQPQEPRVRRFPEGTSQSGRQRFWSWLHDRFASAAEQDTHWRLMYDVTPTRKKQHVQGHASSPSCLFCGNDAAVIETVSHYFFGCAYSASYWSGVLRILFDKLGIEDTDVDPSTFTQEQLTMGLPLLRGRGRTTSKWMWVRLACAIGFQRLHLLRWHVHQRFEKDRVVAPPSIPSALRAFNRDYLSRAGFVPGARDWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LSW3</accession>
    <name>A0A2X0LSW3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C011g06282 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C011g06282</name>
        <name evidence="1" type="ORF">BQ5605_C011G06282</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY11820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LSW3"/>
    <dbReference type="STRING" id="796604.A0A2X0LSW3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY11820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="995" mass="111546" checksum="3086D6E24079C518" modified="2018-09-12" version="1">MSCARLSETRIAHIEPPRSLRALRRSQPPLRLDLPLGSSYLEDGEELVVPTDTSLPIALLDESIIPSDGHPPPSFLAGVGPAPRIQRQFHFGVPSFDPPNLSLFTSSSSCKHPTGPLPRATFSPGRLLLIDETQRQHPSQFNFTQTINDKYLEELLAEHPDQPLVHSVVQALRHNGFEPEHDSSVPRGNTKLHNLRFSHDEFHRDFIQRTVNEEVQKRWISSGTGTPLPGVTYSPVFVVESENHRRRVVADHSASRLNNGIDRSSCPATYDTIIDFIRLLRWHCFLNAKGSLLGQDAVLWKLNISSAFKILVMSKRWQAMQNITIKRHLEDGSTVTWYHIEWRGVFGCRAMPFLWTRFMSLLMWAAHRWYGIEHPLAYMDNTFGIDLVGDLVPFAHNGVTYEIPAQQAAMARLWGDLWIPFKLAADKAPFGCRVTIMGIDCDLDEFTVSLLHSTVMKLAAAIESFLQTPGRHPTLRRWQQMAGWLSWALNVAPQARPYITPLYHKIRGKVNSNTGVPINKDVTEALTQVAVLIARGPALNLVSPSLTRWSLADADLVIYTDACLRNADNTGAGLGFWLATAGGTRRHFYCRPRRTYLRIQFAELLTIIRALDIATDPTRGYGPFHHVLVWTDSAPAVYALDSGAAHNTDFMPLCMLTLAAYKIASTRNFDLKVAHVAGDHNTIANDLSQGGRTVNFASRPLMAPARPAQPFPSLDQLVIGTAEMSLRALEPKTRSDYARAFRQWNLFVSYYRYPALPMVVSLCQFVYWQYRLVSTVYQTLSGLAHYFKPIMGDEWNRIRSCCAVKLVIIGGIKTWRRAAKRATPLPFALVDYSLKAGVSDAAVSYDPLVFLAMVALEFGACACCAELCTPNTVAYRDYNKLPRCDTVKIKKDSFIVHLPYHKANRRWQGSHFIIVCQATSTRSLIFFRGILLHETNNSRTQTSSSLRATVTLPHVHGSSVVFKASSDRITAGTPSDPAVQPTTLYEATQRIRSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LU70</accession>
    <name>A0A2X0LU70_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C010g05837 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C010g05837</name>
        <name evidence="1" type="ORF">BQ5605_C010G05837</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LU70"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY13336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="536" mass="58271" checksum="82C13C323E7927EE" modified="2018-09-12" version="1">MAPKRKLRPPPINYSSFETAAAASLDSEQWLQDGVQQESQGDRYQHGAKAARHYHNAIVSYRLAASRSTSPAFDPVYNAARVMFTLTSDHLEASDCVDMMQRAIATFRMAQTAATSTDEVIDSSFNLAQALVALQDLYDDGISIFSSPSKASSSAATGSDHARLLAAKRIFSEVEQLQRSALDPIFREGSTDTPLEVDMQDATAADPGSIHTAAATEGRIVVPRQVIDTLLEAIELDLRLLDLVSTSDPTTSATLAESAVSALSRAAELSRFGPSSSSSAELELVLAQISVNTSCRGAVPTNHALYLAPEQVLSTINALASSRQDDPSLLCAAADHLLENSAPSAGSIPRLEFIVTTYQRAHALLSSRLSPPKDVPAHRIPSLVASNLVSQVETLLLLFHLSPPERSSAYLHRARDQAIEAIKASSFGYTVELAPTVRILKLPGDGRRDWTTVKAFRQGWFWLVRVLVHAASGPAGSNGWMGLLRAWDKVALPTECTPGWMSQLRWYLDVQEWPSDRVWEASHGKEQEQWAKVLMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LUC2</accession>
    <name>A0A2X0LUC2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C010g05887 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C010g05887</name>
        <name evidence="2" type="ORF">BQ5605_C010G05887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LUC2"/>
    <dbReference type="STRING" id="796604.A0A2X0LUC2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="1">
        <location>
            <begin position="10"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="1">
        <location>
            <begin position="180"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY13539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="319" mass="35082" checksum="DA4F2E5147D38010" modified="2018-09-12" version="1">MSASTSTSSLWTPLKVGLITLSHRIVMAPLTRIRADQDHVPQQVAAEYYEQRSNTSGTLLISEATLISPQAGGMGNAPGIWSEAQIQGWKKIVDAVHSKGGFIFLQLWALGRAAGADNLKQEGGFDVVSASDVAFEGGYKPRPLTEDEIKQYVADYATDAKNFVERAGGDGVESELLTAKAVGADRTGIRLSPYTTFQGMKMPEHQDIIDTYTYYVKQIKERQPELAFVHAVESRIAGNVTEDADERETLDFLYDIWTPSPFLVAGGFKREDAEPVTAARKNTAIRVRKGVKFADYDRATFYIPGPQNTKGYTDYPKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LUG2</accession>
    <name>A0A2X0LUG2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C010g05927 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C010g05927</name>
        <name evidence="8" type="ORF">BQ5605_C010G05927</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LUG2"/>
    <dbReference type="STRING" id="796604.A0A2X0LUG2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF51">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="479"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="503"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY13646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="560" mass="60720" checksum="1DF682A08FC31B59" modified="2018-09-12" version="1">MALNHAVGGTHVDYDDAPILSLDSPSMRVPGSPSASDGGHTPVTEVAAAVPVDHDNDPRVDQIATSVTLTPTLIEDYTIWSKIKVRLICITVAFAGLFSPLSSNSYFPALPTIAAPTLWAAVGDVMGRRPVYIATTTLYLYSNVGLSFTYHYWLLLLLRCVQLTGSASVVALGSGTIGDLIPPARRGGRMSIYNIFTMIGPSIGPVIGGLLANSFDWHAIFYFLAVFSAVVLVLLVVVLPETLRSLVGNGSIPARGINRSWLSTMQERKIRAITNDSSSTLDHNAARTHAKPKTWRDIDLLASVKIIANVDVLCLLTFNSIVYGVFYMVITSTSTIFELNYGLSEAQIGLCYLANGRGMVAGTMINGPALNRAYAATKRAHDERLRASGIKVPDVIDRSDLGVFPIERARLKSLPGSVAIFVVCSISYGWSLQRIWPLAVPLVLQFFIGTAAMIQFNAITTLLVDLYPLASASATASNNLIRCLVGAAATAIVNPLIQAIGSGWAFTAAGLVIVSVTPLLWVEWEYGQRFRSRRRARLNDKIMAREEQKRKEPEERKAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-11-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LV26</accession>
    <name>A0A2X0LV26_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C010g06097 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C010g06097</name>
        <name evidence="4" type="ORF">BQ5605_C010G06097</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S11 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LV26"/>
    <dbReference type="STRING" id="796604.A0A2X0LV26"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054179">
        <property type="entry name" value="PSD13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035298">
        <property type="entry name" value="PSMD13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22037">
        <property type="entry name" value="PSD13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="197"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY14197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="428" mass="47877" checksum="081BEB9827F78DD3" modified="2018-09-12" version="1">MAPKMDVDQSDASVYLTRQLSSPSLPHELKPFYQAFERFYNNKLWYQLTSTIENFLQVPSSGPYQIELWESFVSTFAQRINQLKLITIGISTARQFSGVVEHGTQGLHFLTRLAGKVDTPETREAYVLATMEAAYFKLLLGDNEGTKIAIDTCAKVLDAMDSVDLVVHASYYRVAGDYYKLTTPSRHFAQAKAEYADYYKNSLLYLACVTVDKDLTLPERVQRAHDLAISALLGKIYNFGELVRLGHVGEMVGGLGTDDRSLSAYIQLMHPILDSLNGTEYAPIKNLLFAFNAGDIGQFESLSHAIAQEPILQENYSTLRQKICLMALIEAVFRRPTSERVLPFSVIAADTRLPIDEVEHLVMKALSLKLIRGTLDQVSSTTSISWVQPRVLDKVQIAGLRDRLAGWTDQVTSVGEFTQSQAPELFAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-11-27" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LV55</accession>
    <name>A0A2X0LV55_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="5">5.3.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Phosphohexomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phosphomannose isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">BQ5605_C013g07121</name>
        <name evidence="18" type="ORF">BQ5605_C013G07121</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="5"/>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY14835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LV55"/>
    <dbReference type="STRING" id="796604.A0A2X0LV55"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07011">
        <property type="entry name" value="cupin_PMI_type_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.441.10:FF:000001">
        <property type="entry name" value="Mannose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.441.10">
        <property type="entry name" value="Phosphomannose Isomerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016305">
        <property type="entry name" value="Mannose-6-P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018050">
        <property type="entry name" value="Pmannose_isomerase-type1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046456">
        <property type="entry name" value="PMI_typeI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046457">
        <property type="entry name" value="PMI_typeI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046458">
        <property type="entry name" value="PMI_typeI_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00218">
        <property type="entry name" value="manA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309:SF0">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01238">
        <property type="entry name" value="PMI_typeI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20511">
        <property type="entry name" value="PMI_typeI_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20512">
        <property type="entry name" value="PMI_typeI_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001480">
        <property type="entry name" value="Mannose-6-phosphate_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00714">
        <property type="entry name" value="MAN6PISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00965">
        <property type="entry name" value="PMI_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phosphomannose isomerase type I catalytic" evidence="16">
        <location>
            <begin position="6"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphomannose isomerase type I helical insertion" evidence="17">
        <location>
            <begin position="183"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphomannose isomerase type I C-terminal" evidence="15">
        <location>
            <begin position="347"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF20512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="SGY14835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="436" mass="47972" checksum="9628BA4F8989735A" modified="2018-09-12" version="1">MTVSPVFELVCGAQSYDWGKLGKDGSKVSQFAQGLPDFKYDEDKPYAEVRHGTSLWMGTHPSCPSTLLETKENLKQYLKQHPELLGEKVVKHFGDDLPFLFKVLAIRKALSIQAHPDKKLAKKLYDERPDIYKDPNHKPEMAVALTPFSGFCGFRRPSEIASFLSSIPEFASVVGDKVAESFRSKFGDNASPSEEDKKAGLKDLFSALMKADEANVKTQVEKLVERLAKEKNQTEETRLVATLNRDFPGDIGIFCTFCLNIVHLKPGEAVFLKANEPHAYLDGGVLTAQLAASGFCMATSDNVVRAGLTPKLRDVPTLTTMLTYTSSPPSEQILPPVKFRSTQHTTLYDPPIEEFSVLLTVLEQGQTEKFEPIDGPSILIFTELQGDASAELKVGQEKGSEVTRTGQVFFIGASVEAEIEATGGKVVAYRAFVEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LVJ9</accession>
    <name>A0A2X0LVJ9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C012g06753 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C012g06753</name>
        <name evidence="2" type="ORF">BQ5605_C012G06753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0LVJ9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1348"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1350"/>
            <end position="1368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY16077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1375" mass="153888" checksum="9AE2B830DE13C369" modified="2018-09-12" version="1">MARVDVEQRTWSVFNSLSNVRIDEITRNSALALFDYLELRILNTEPKQGRMVQQADSFSCGPAAINVVETELLLVPPFSAGRAHISRIRQFHRLATFAIKSQDLTHDLPAPIAGIDKNDLDVGVFEEMAEMEVDEETWSEICFSSDSETDDDCTTDDETPKPGESITARRARLAKEHLKDIEYSKARPAAFAEFKAKVKQLCPGSDVKIANPRTVQCGRCRTYHKMKTRHGVNRFMRHINQNPPCTNMRKVDHYFAVRPPAETARVERYLSKSSARGGGAPSRLKLIKRRFPRLGKRVLTPSERREINNLEANEWKWVNDHSAPRVNSIDCTKIGVESQCGTKSQPCAKCKALLRTKAFPPALYRPRAVGPTIKFTNKRLASVDALMSKVFKEHQGLEELLGTKDGKIYHRYAQGLIVGELAGANILKGMAKVAVIKHRRNAQGKDMRGYVRDEALLDFEHALALASPTALRVVQKTIGGISMRTLQQHRATFEKPRFGLDEPHMQRVVQKILSDGKTFNLHVEDTKLRQVIRTTRIYSKDKEAEARLRGQKIFRHELIGMVGPPIVYETTRELEGIFRGPNPPIAGTKVRVYMLAPNDVSCPAQYLAAFVIGDSTSSSEAADELESVIQFLVNAELGHLLASISADGAASEGVLQRVMAKRLGGDEGYTGEGNRRRELAHVIPSPGPDKVFPAIRLASVQVGNTPTCFNRDEKHLSKNLRSACDSGARAIYGGTGCIGYRDLLTLLDVEESARTLYLRDVVGRDRQDDNATHRAFSEATLSLACRLHEDGKVDADAIVFLFLCGELHDAIQNRSLQPIERIKMLLTVRYTFEGWLTFERNRPGYNAQSFVAKETLDGMRKVVDTNIALIRNYRDFWPEEAFIPWRHGTEMVEHFFGGLRKVVQEFDALEFLQSASKVTALLGLMRKLKTETAGSRQGYHHTYDRLDDLDLVAMRTYPNDEEIQSTSLVAAGLAKELLLGLRMWDTIHYQKSNQVEEEIPVNASEPWHFEPEDTEPVSYLADLDRTLNGIRTKTCQGLVVLDPKERKLAVQQAYDEADAQAEERFLLDAIETANESLPGRAQILRLPSLLRHDTRQLALDLKSLTEHRRAHQCAHLKVVLLKGKHGAPTSTAQDFDQKRNLQSMGAARLEAVSGVARSIRWTGQGTFSRFSTANETDNIGYIEDGRKEVRMQLRARQYTVFAKIPTFGSIDGNVTSAMPLKIGSFVCFGLKRGIIPVSCDASNIGEDQLSIGLVRYMYAKATSNHCDRAETDSLALLSNVVLQELRVVSKGRYSTHMIDGTTRFFGLDARHIIQSLESSSTPQAEARFCFLRRYNGLRDASVSLSNQMKGVKDVGSKRKAASADKEPSAKQNRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LVM1</accession>
    <name>A0A2X0LVM1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C016g08255 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C016g08255</name>
        <name evidence="2" type="ORF">BQ5605_C016G08255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY21588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LVM1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY21588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="443" mass="46776" checksum="BBBAD589FCF8167C" modified="2018-09-12" version="1">MSDVHVFHNQMNMMPPRLPQQHVSIAYTPESQYLAQLQAQLQHQSQLLLLNQQALAAQRHEAEAAFQAMTLGQLAQHPNSFGSGATQVQTFQATRPRTTQLNGFGIVSPKEAVALERAPSARSDTTGPSAIDEINAMSNPLVASALARRKRQSVNLEAAVSSEQTSRVAAPPSSKTDADPSISPSTDSSSTWERHGRSSSMNSSSTASSLIRTPPMPNDPPAFILSRPGEPFPDTSGSEGGSSRAGSPTTAEMPFKQRPSIKARLEQVPTLPAEGLNTLSDPEVFELVLDRPGSGGAGASPPRASHLSKLESVLKGRRQRVTSTPTSTVELQDASVQVVSVAPSLSPFAAAFVPPSPVSYTPSSPSFNGSSPQVPSSPFSGGYRSNRPAAVPGTASASRQPRGPPSDLNGNFATRMRRKAVQALLQGRVDRVAAGQDELMPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LVZ2</accession>
    <name>A0A2X0LVZ2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C013g07279 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C013g07279</name>
        <name evidence="1" type="ORF">BQ5605_C013G07279</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LVZ2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY15180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="114" mass="13119" checksum="42A61F04785F008F" modified="2018-09-12" version="1">MAPLLDVRVSELFASSFDKSDTRIQLSWSTDEPLELESFARPLDALRDKLKIVEQSLRHVGKATSLSLSAAFRCRIWRHINHAERMRLVVLNQRPIVRALEVMPSLLVEEQLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LW17</accession>
    <name>A0A2X0LW17_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C013g07309 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C013g07309</name>
        <name evidence="9" type="ORF">BQ5605_C013G07309</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LW17"/>
    <dbReference type="STRING" id="796604.A0A2X0LW17"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF184">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="8">
        <location>
            <begin position="118"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY15272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="381" mass="41818" checksum="FD82A75C6170D62D" modified="2018-09-12" version="1">MPNSRGVIKVLKNITKTKASALPPCTCSALGSRPLARLDHRLPSSVAPLGSNASSVRHYSLSTTNTPTSSNSKQSSLPPTRTSRSTLLAYIAVPSLLGAFAYQQFSPTDNSKRPLSPDYFIPLKINKVTRLNHNNTLIELDLPDSLSPRQYISAQKYRRDEDPWRIHSIFVKQPELQIQRPYTPLNTSFLNRSPSESSPSTTIQLLIKRYDDGEVSRYLHRLGPGDQVQIRGPVLTTELPKVDKIVFVSIAGGTGITPAHQIITSFLHHPTADPPPSISILYAAQEPVLASSLEQLQKNAKFPVDLKMFSRMTNPSRITEEVLEQELGRAKDGRDDCLVVVCGPESMITELAGPRARDLSPGPIGGVLGKLGYTSNQILKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LX01</accession>
    <name>A0A2X0LX01_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C015g07769 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C015g07769</name>
        <name evidence="2" type="ORF">BQ5605_C015G07769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LX01"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY17393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="361" mass="40786" checksum="AC45CC8EEAE0BEF6" modified="2018-09-12" version="1">MTPEGCSDDVDSTADSDPAVDDSEASSSDGGEEAMDRLRQLEYDTMQAKRQAIMSSNRLWSAEEKADYEQWPLILGDRRKADEWTLKDTIPILKLPVYMATELFRYWEKRLNIVAFLMARAEGPIPRVPGGSDRPTIPYAEWERVIVKPRVPKKGDLMPRTEFTRQPDGNACGVFVCRTMETLVAAVAFQSELDWSWSPLKPLQDNFYADQRAYMLDVVIHPRLRCDTELETNSNPLPSICKRGLELLRCFPKLSHSRSRRVRRSSKRSPRDRPALKFPRLVLIDPSIGTIPRPNPAPSIATIGSTPDAPLMRLQRVVRFDPTPPLPVSEALEVVACLPRYQTRTLAVRSIVAISTPVGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LYB8</accession>
    <name>A0A2X0LYB8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2-(3-amino-3-carboxypropyl)histidine synthase subunit 1</fullName>
            <ecNumber evidence="4">2.5.1.108</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Diphthamide biosynthesis protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Diphtheria toxin resistance protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">BQ5605_C002g01253</name>
        <name evidence="17" type="ORF">BQ5605_C002G01253</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DPH1/DPH2 family. DPH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="4"/>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY31713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LYB8"/>
    <dbReference type="STRING" id="796604.A0A2X0LYB8"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035435">
        <property type="entry name" value="DPH1/DPH2_euk_archaea"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF1">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004967">
        <property type="entry name" value="DPH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00060338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="SGY31713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="576" mass="61885" checksum="A94B473160377581" modified="2018-09-12" version="1">MADAAAPAKAHRKRFVGRSGIPPSGANGAPSSSTARPSSSSSTSFAAPISVSPVVDPLLAAAIGHLLPGNYNFEISKTIAQIKRNNATRVALQMPEGLLMFACAIVEIIERFSDGVECVIMGDVTYGACCIDDYTARALGCDMMVHYGHSCLVPVDTTTIKTLYVFVEISVDRPHLAASIRHNFPQCIPTPSSSSALSAITRSSKGKGPELEIEVESTQSERSTVTPTLQGEGKRTKLAVVGTIQFVAAVQGLKADLEKDLPEEQQPVERLAIEAPRTSGDVSSTPDAPIANRQRARFDVVVPQVKPLSPGEILGCTAPRLSKDVEALIYIGDGRFHLESIMIANPLVPAFRYDPYTKRLTRELYDHDEMKSVRADAIHQARESLKSSSVKSSNNDDSGVWAVVLGTLGRQGNLRVLRSVTKHLAPSAMPQSVSDLKTSRPATSTSFIPMLVSELSPAKLSLFRGISVFVQTSCPRLSIDWGYAFPRPLLSPYEASLALNVTGAKGWSGIGLPAVEEGRAIASEAQHVDNYPMDFYADQSMGEWTPRHGMGIKRAGGEKGRLVPRSKRPVVVPLCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LYE0</accession>
    <name>A0A2X0LYE0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C017g08335 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C017g08335</name>
        <name evidence="3" type="ORF">BQ5605_C017G08335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY19826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LYE0"/>
    <dbReference type="STRING" id="796604.A0A2X0LYE0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015866244" evidence="2">
        <location>
            <begin position="20"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY19826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="123" mass="13714" checksum="537385AD13A79DC1" modified="2018-09-12" version="1">MAVLLRLLIQLASLGFLYSAFIAWDGQSKTRVDARSSIKAEWIPPPSHRFSQAIPLPLPVRWRFVFVILQVLAAFALLTIGLLWSANSLAKISWASEMADKTIDTQDSALGFPNVRTRASKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZ80</accession>
    <name>A0A2X0LZ80_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial inner membrane protease subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C002g01593</name>
        <name evidence="14" type="ORF">BQ5605_C002G01593</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S26 family. IMP2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY34139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LZ80"/>
    <dbReference type="STRING" id="796604.A0A2X0LZ80"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.109.10:FF:000005">
        <property type="entry name" value="Mitochondrial inner membrane protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037730">
        <property type="entry name" value="IMP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041:SF2">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Peptidase S26" evidence="13">
        <location>
            <begin position="57"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="213"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="226"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGY34139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="247" mass="26752" checksum="A2A3A469A02FA175" modified="2018-09-12" version="1">MASTSRARPTPRPNSHPNPNPTGSSSSSFSSSSSSSSSGPRARLRSHARPWLNALAWLPVIFFVDHHVVSFAAVSGRSMQPTLNPDSSKLRQDIVLLNRYKNLELTQGATRTDPKAGYQIGDVVALRSPTNPSQLLIKRLVGLPGSLVRTLPPYPERTVRIPAGHCWVEGDEKNHSKDSNTYGPIPLGLLDSRIEAILWPPSRIGAIPKSTSGWEKRVMHPPGMTMGSSTTMSPESKTSTRVIGGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M1I3</accession>
    <name>A0A2X0M1I3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01051 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01051</name>
        <name evidence="2" type="ORF">BQ5605_C002G01051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY29423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M1I3"/>
    <dbReference type="STRING" id="796604.A0A2X0M1I3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016066199" evidence="1">
        <location>
            <begin position="18"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY29423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="116" mass="12802" checksum="F8F7D9AF21992FFE" modified="2018-09-12" version="1">MCLCLWYLRGCAWGARGAFFPRVCLLLIAFSSLALHCGPDFSASCTLTYRKRIGGPGQQSGSHRTTIGMDAVTPSTETSDRGLHVPILRASNYMNWRRRLMGVLGPRICIFVHRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M207</accession>
    <name>A0A2X0M207_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C002g01222 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C002g01222</name>
        <name evidence="4" type="ORF">BQ5605_C002G01222</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY31329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M207"/>
    <dbReference type="STRING" id="796604.A0A2X0M207"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18888">
        <property type="entry name" value="NUDIX_ADPRase_Nudt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000016">
        <property type="entry name" value="ADP-sugar pyrophosphatase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF26">
        <property type="entry name" value="ADP-RIBOSE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="64"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY31329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="224" mass="24675" checksum="63D3B9287FF68A9D" modified="2018-09-12" version="1">MSSSSLSSSPLPKVAPTRLGKSVITSNKPLDDAKWIELRALEWTDQDGKDRKWETVRRKTTNEAGVDAVAIATLLKHPSRPLSTIVILQYRPPIDAICVELPAGLIDANEGPEKSALRELHEETGYGGPAFEGRIKIVELGGVVPSDPGMSVANMHLATVEVELKEDEEEPEPKLEPGEHIEVRVTPLAELYLHLKAYEKLGYTVDARLHHFAAGIEMAKKYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M2A7</accession>
    <name>A0A2X0M2A7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C002g01342 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C002g01342</name>
        <name evidence="3" type="ORF">BQ5605_C002G01342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY32274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M2A7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="2">
        <location>
            <begin position="336"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY32274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="479" mass="51665" checksum="D9B483C50376EFAB" modified="2018-09-12" version="1">MSSTGSVGGPGQKSESHRTTIGMDTDSPSTETSDCGLHVPILRASNYMDWRRRLIGCLGSKDLHLCASRPLSDAAKAVLQVAINDRSRGFHSPLERLDFAAMDAKIAKELKKEVRTQAEIIQFLNEANLRLVRGCYASYDILDSLNTFYLGTMSAQISALTTELYARKFSSGDRGQLLHHLITIQGILQDLEACGSGMPPAQQSMLMLDSVFDPQHESFTSSLRRPLALPSEIVSEARSYQFKVSLASRINGLSATTSGRAMAPRLKKGNRDGQGNHCPTDSTCHACGAKGHWSCDAVCPEKRSKSSAAPALVAMNSHSVYLAGSSSRAPNADFVWIADTGAGHHFVGDRSLLSDFKESPIQVQMADNSLGQATGYGRMSVKTSQGHLLNFKEMYYLPGSKYGLISMSSLRAGGAKLVYGHGGDTQQVWLDGSLVAETVKTKAKQPSYVFDFEIVSPPSPVLVAATRASVGALCKVRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M4C3</accession>
    <name>A0A2X0M4C3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C003g01882</name>
        <name evidence="6" type="ORF">BQ5605_C003G01882</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY37757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="4">
        <location>
            <begin position="374"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="1049"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="5">
        <location>
            <begin position="1349"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="326"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY37757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1533" mass="171682" checksum="77EE79163142610D" modified="2018-09-12" version="1">MNRKRVALHDIASTAELCLTCEARAGVCHVMRCAGGGKKPSPLCPGPKVVATDGSAVPWACSSARCWAPRGSTLFFLPLAPGSNRAQTPQAHVSIRDDLGPQTAVCTHCKARHWELGPPVFRVFGRLYHRLGALIPAVTQRPTFAQTWLIDPAEATDTRLQGPDSAETRIQRSTLTKLESMLRTGNRFVREFASAKARAGWDTAKDWVLRLCLPPGRDRRTHNLPTSSTEMAMLICNSDTNTGDRGPQDLILQVHGDRCPDGRPKYQIVSSLHPSAMPLRYPLLFPAGEDGFHPNIPLCGFNQAGPPIARNREQIDNGVQLRELLDGLGPDEEDEEEDDEDEGDEEDEENGDGERRRSNKRVRGGSTRVSRSQYFAYHLHERDDYFSIPHATQRLFLEFVIDGYSQVETDRLNYIRLHQESLRLTTAQGITDAVANGLTPDQIGRSVILGSTFKNSPREITQHYQDAMACVVKYGKPSLFITVTCNPEWPEIKAALGPNDKACNRPDLIARVFEAKLNRLCDDVFGNKQRAGCFGVVLTHTHVIEYQKRGLPHAHILITLAPDDHPLSTEAIDKMISAEIPDPSRYPDLHETVTKHMLHGKCGGNSTQPCMEKDKYGNPRCKRHFPREQNPHTRMHPEGYPLYRRRFRHAVVKGGVIYNDGDCVPYSPYLCAKYNAHINVEAVTTIGAIKYLFKYVYKGPDRAVARVERAANGEGAREDEPVRDEINEFVEGRYISAPEAVHRLFGFSVGRVWPPVNRLPVHLENQQSVQINPNEPLPLDTPPTRSKLTGFFDLCAAAPDGELTTTLLYTNVPRYYSWNKEKLRWKRRVHDRNVIGRIYTVPLRSGERFYLRLLLEVVMGPTSFADLLMFEDVVYPSYRAACAARGLLADDGEHHICLREAAQFETGDQRRRLFVFMLIHATVANPPALLDRHFASLSDDARYHIERYEDVPVNDQTIRLWTLNKIRLLLAANDRTLVFFDLPELTEDEVRLFDRLEERLPRFDRQQCAQDAEAAHARLNHDQRIAFDECLRAVELDVVDQMRDNNLGPQHVFFLLAPGGTGKTFVENAPLDTVRARGDQAIAVASSGVAALLLKGGHTAHSTFRIPLDTLPTSTCPVDRESDLALMLRTTKLIIWDEVPMAHRFAVEAVDRLLRDLRETEEHFGGVTMIFAGDFRQCLPVVPKGAPGQIVDASLIKADFWRDVRVLRLTENMRLSSNADAMDEAQLARTRDFAEWLLTVGDGTANMRPYDKIALPDYLLLPDGQRTAEGLINFVYPGLRTVNKESLEDLIQLFSRQAILAPHNATVDRINAKLLEEFNGDYIEYRSADEVVEAGETGGGMAPELISPEYLHSINPSNFPAHHLHLKEGIPVVLLRNLDPDAGLCNGTRLIVSHARSRVIQAIILTGDRAGTTVFIPRVRLETNATGSRQLGFTMRRLQFPLRVALAMTINKAQSQSLDRVGVDLSLHPVFTHGQLYVALSRAMSVDRIKVLLPSRDPADDDDDLQAVDRAAAAATATPNPVFRSVLRAMNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M4N2</accession>
    <name>A0A2X0M4N2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C003g02254 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C003g02254</name>
        <name evidence="4" type="ORF">BQ5605_C003G02254</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M4N2"/>
    <dbReference type="STRING" id="796604.A0A2X0M4N2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050995">
        <property type="entry name" value="WD-F-box_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604:SF4">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604">
        <property type="entry name" value="WD40 REPEAT PF20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="80"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="122"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY39643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="363" mass="38491" checksum="DACBAE4027E38161" modified="2018-09-12" version="1">MITVAQTTTLECSCEQLAIPPTLVHFPLRTDRLADFGPVNSFDIAPDGSRYVVGGDNGLVRVVELSPSHSSTQAPRQIALKGHLADLTVVRFFPSSEVVLTGAMDMTIRIYSALSGKEVRTLTGHTKSVSGFFILGKGRRILSSSLDGTIRLWNIAEAKVERTWSFDQPVSAFTVSQFTGSTALAEDYPEIEELYAIAAHTNGSATALPLGTDTAAPLLRLRAGSSPLHSIALDSDSGRLALGSRNGCVALFQLPALDAASPRPAQETLAPLLTLSRSDTVVHRLCFSTTSNLASTQDLLVAGADGLPFRVTLRQDPSDATSTTASIVDEYSGLDCEAATSAMTSNGCIWVAGADGMIRRYEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M4V6</accession>
    <name>A0A2X0M4V6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g02324 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g02324</name>
        <name evidence="2" type="ORF">BQ5605_C003G02324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY40099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M4V6"/>
    <dbReference type="STRING" id="796604.A0A2X0M4V6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="1">
        <location>
            <begin position="236"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY40099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="375" mass="42507" checksum="B7495ED4FED9B12D" modified="2018-09-12" version="1">MAVCINYKARHWEYKRSKSTGHYSTCCSHGKVQLPPLSGPIPSIDSCLKGRIPALKDPACFGFFDAFTIDWAHSRRPSSCHQSAPNLCQNMAHLPGRGHRHSTWTRRRRQSHTKIYFDQARFYVAYRQSLCEGICIGQSSRRLGQRIVDRKTLFSRCTVIEVPMVGPSTKSLARSIRLRCLSVTHYSSPQRKIASTSTLLFARSTKLGHSLPKDRDEEEGDAENGDGELSRSQSFAYYLHKRDEYFSIPHCTQRAFLAFVMTDTPRSRPIDSTYLQLDQENLRLTTGQGIISLTPDQVRCSVILGSTFKNRPRENTQRCQDAMACVVKYGMPSLFITVTCNPEWLKFKAALGPNDQACNRPELIARAFEAKLNLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M671</accession>
    <name>A0A2X0M671_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C001g00048 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C001g00048</name>
        <name evidence="8" type="ORF">BQ5605_C001G00048</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY43701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M671"/>
    <dbReference type="STRING" id="796604.A0A2X0M671"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="7">
        <location>
            <begin position="254"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY43701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="448" mass="50913" checksum="3F210EED583C9FC3" modified="2018-09-12" version="1">MITALSSAASAVVDAGNSSQVSEELQQNRHTRQRSSSGSSSGSSSLISYDDQEVVQPEQPVKTTRQKVDRRPPSTFHKKKRTEMTLAENLCHIATCPDVMHELKDESLDRGPIPTRSLFLENVFIITRGVAPMVIQQAAYHYYPESKWPFYAAYPFYLLSFIGFAVAVLGRLTRACVEYGTFDEKQIGRDRTPDKAVNHLAVGILAREDFLLFCDHAAYMFVRTGIAFFLYYDKEVSPLNQFTWSYPFRLMAWEIVFDYFFYAYHRTSHEVDGLWFVHQHHHTTKHPTAVLSILAETYQEYLEVLLVPLAATLVVKQSFAEQYLTFCYTIYVEMMGHSGVRCYWSHPILSFLKVFNMELAVEDHDLHHRGGKSGRNYGKQTRVWDQIFGTEAAAFGSGGFVSGTSSLRFSTNGKDMVLHDVLHGPGLEAELDTLHFLIKDGYTICITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M699</accession>
    <name>A0A2X0M699_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g04206 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g04206</name>
        <name evidence="2" type="ORF">BQ5605_C006G04206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY56991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M699"/>
    <dbReference type="STRING" id="796604.A0A2X0M699"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY56991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="407" mass="43300" checksum="45439B2668780DC1" modified="2018-09-12" version="1">MASVGSSFEGVPSSNLYHCPILGMMTSALVVSDATVNQALTSLSAALDRLRALTFKTRGRVSSGDHAPQLGRPCSDSLVVAGASQNSIGFGLSPSINISSLSSFSSGPPIVEWHDVAAQRFARLALTTLIEWASVVRALQEVYTSTANSSDPTEHSSDSGSEIKIAGEYGLELVLRVLKRFQRFEFDDDKAECVEWCQRLEGMIQAQIVKCQTATAPPVVKDPTVAATSSNVNSEMVPSFSRPVLSRNASPAETPVAAAPAANPLSIQDTALSPPAQLAPHQAIDSSPSVRTGVLASWRSHVEETSQASNMMASLSPDDSVAELTRTKKRSARAAQLDQVRVLSQPALAFEAKKEPRIESTTLTDRGSSRHARNVSHSSTKSASPGLSCQSVYCCFIPLLLPITISY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M6K3</accession>
    <name>A0A2X0M6K3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dolichyl-phosphate beta-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.117</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C001g00369</name>
        <name evidence="14" type="ORF">BQ5605_C001G00369</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-alpha-D-glucose = a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate + UDP</text>
            <dbReference type="Rhea" id="RHEA:15401"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:15402"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.117" evidence="4"/>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY45998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M6K3"/>
    <dbReference type="STRING" id="796604.A0A2X0M6K3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004581">
        <property type="term" value="F:dolichyl-phosphate beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04188">
        <property type="entry name" value="DPG_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035518">
        <property type="entry name" value="DPG_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859:SF91">
        <property type="entry name" value="DOLICHYL-PHOSPHATE BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859">
        <property type="entry name" value="GLYCOSYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="13">
        <location>
            <begin position="90"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGY45998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="385" mass="42404" checksum="4D8DBFBD9EFCD44F" modified="2018-09-12" version="1">MSFSAPTSPWLWVACAVLVPALVSVLSVFYCAMLTLPDLGLLPQAYSTLVLLSPRDPLPHASESTCRTIDSDTPVQLPSLLDSPATVQLSVVVPAYNEADRLEAMLTECIHYLETRPLAIDQPRITASDVDLGSYEVLIVDDGSKDDTAKVALQLSRKLHAQFGGKRGQVKVAKLRRNRGKGGATKHGVMHAAGHHILFVDADGASHFPDLALLEAALDRLETQQRRTSAKLPPHGVIVGSRAHLLRTEAVVKRSFLRNFLMRCFHAYLHLLGIRAIRDTQCGFKLSTRASAAHLYPSLHSPSWIFDCELLLLASLAGVPLREVGIRWHEVDGSKVDLIKDSIKMAVDLLVIRGNYLFGRWKRPAHVDVVDGGEDESAEEERKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M7S4</accession>
    <name>A0A2X0M7S4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C007g04747 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C007g04747</name>
        <name evidence="7" type="ORF">BQ5605_C007G04747</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY62871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M7S4"/>
    <dbReference type="STRING" id="796604.A0A2X0M7S4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005371">
        <property type="term" value="F:tricarboxylate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015742">
        <property type="term" value="P:alpha-ketoglutarate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053017">
        <property type="entry name" value="Mito_Cit/Oxoglu_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46982">
        <property type="entry name" value="CITRATE/OXOGLUTARATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46982:SF1">
        <property type="entry name" value="CITRATE_OXOGLUTARATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="11"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="219"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY62871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="320" mass="33743" checksum="2AB52E58626B9E0B" modified="2018-09-12" version="1">MSGTTKKPSPLSWTNLAVGASVSLLEVTTFGQPLEVLKTHMAANRSDNLRQAIAKTHARGGFKGFYQGLIPWAWIESGTTGAILLFTATGVESVATTAGVSKAVAGMLGGIAGGAAQAYLAMGICTTMKTAEVTRAKAVVIPSTIPGQPAAVLPAASTFGLFMQMYREGGIKGINKGVNAVAIRQMTNWGSRMGFARAAETLIRDARGLPEGKALDMQDKVLASAIGGALGCWNHPIEVVRVENTDQWEALLLKMQSLKKTTSAAVARPTTMASTFKTIYQEAGISGFFRGVTPRIGLGVWRTVCLVSLGDLVKERIAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M7W0</accession>
    <name>A0A2X0M7W0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C001g00598 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C001g00598</name>
        <name evidence="3" type="ORF">BQ5605_C001G00598</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY47989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M7W0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039191">
        <property type="entry name" value="Nopp140-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216:SF1">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="487"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="659"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="525"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="661"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY47989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="743" mass="81060" checksum="7765D61877695B59" modified="2018-09-12" version="1">MIRRTYATSAELEAIAAPTPPPQQQQQQPPGAQPPASSLSSSVHINTLLEATIPELEEEPTMAYLQEEKTSVRVEEGEIVEMVGEGVDQQMGSSEPINNPPAATLRLPSLSSSLNSLPKRPLSSQIPTPHSRRASHSPDRKHRRSNSLTSETGSLLALPVAAQLHVLKARNTTLEATVTNRTAQHQLAMFKATSRIASLEKALAEQQATKKVETDGQDSSTTISQQAAALAQDAEGWQAEAQRLQLELDSLSTSQKTEHDRISYELELEKSKKKTYRFLCAKLRSELHNRKAKEKWDLGVMDAADRARDVNEVQLEATIATLRMQVGIAKVDAEELQETIHRQRKKISALSASRSMLLNSVNACEATISALRSEMNLAKTGFTKEKKALQMEVNALKSSLKDVKEREVELENSVEEMAELKMEIKALKAEALRLEKGEKRSESKDAKELGEVRKSLEKEKTKREQMEVEVKEMKVLLKSTQVELKDAQRSAALKSQAPALSATSNVARKSRAVVQVASDPVVASEPEDDDDDEEEEEQEKEVPAPVVKAKKTSTKLAPVVDEPVSDDQGGEVYKPQKSRSRSVALPQKTKAIIAAATVDVESEREGVAASKKRKMLGDKSGNTSTSPKRDELTALQPEKMKVAVKAKTAKMGLKEVLVEQAAEEEEEEESTAPKKKKKRTLFGGGGKFAWDLIENADVNSLGLPSHLSPIKGGGGLGLGGTRPATTLGILGRGLTGGRKSIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M7Y2</accession>
    <name>A0A2X0M7Y2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C001g00607 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C001g00607</name>
        <name evidence="3" type="ORF">BQ5605_C001G00607</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY48046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M7Y2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY48046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="52" mass="5761" checksum="8A360DB6781935D4" modified="2018-09-12" version="1">MQTHRLQQHESAHSGFGSRTKPQQHVVGQALTTLLASVVIITTLLLRVFVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M809</accession>
    <name>A0A2X0M809_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C001g00959 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C001g00959</name>
        <name evidence="6" type="ORF">BQ5605_C001G00959</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY51090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M809"/>
    <dbReference type="STRING" id="796604.A0A2X0M809"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF77">
        <property type="entry name" value="SERINE THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="314"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="242"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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            <end position="107"/>
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            <end position="136"/>
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    </feature>
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            <begin position="137"/>
            <end position="181"/>
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            <end position="198"/>
        </location>
    </feature>
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            <begin position="247"/>
            <end position="260"/>
        </location>
    </feature>
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            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
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            <end position="777"/>
        </location>
    </feature>
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            <end position="796"/>
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        <location>
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            <end position="823"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="343"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SGY51090.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="851" mass="91793" checksum="A603B905D93C6105" modified="2018-09-12" version="1">MWKTLLCQDANDDSDQEQQPEPTPSAGVIMSPPSSQRAGRELDSASESESEPSSALSSQSQTTRTTSSLAPPTLTIDHSATVEHRSDDDQEAELTPATTMIIPNSVQVDEPSSMIVPTRCPPVITTESTSTSTTSSGQEQAHNPDVETTNKTTDTAPSLGPSSSSKNQLRASSPLLTKLQTPASSSSSSSSSSPAVVSHTLTPPTPVDSPARLQTLRWPIENVHTFKSPLNKSSLLPTDALREEPASDPSIQSPTSDSSSRAARGPATHSTPRRSTSGASGSSSPARNYKETLNAYAVEDEDGVRSVNQYLLGKDKKGSLGKGSYATVERATDRETGVEYAMKEFSKRRLRQIAASEQARRERMAGGGRGRGRGRGRGGSAMVSKRACTQDFDDKQGSDNLDLVRELEVGIAFELGDIALVADLLVWRGIGTEIAIMKKVKHPCIATIHEVLDVTSDDALLIVMELCAGGPIMRIEAGKKTDPMPLDEARRVFQQLVLGTSILMEQVCGRMARFLLGGDLEGVAYLHHNRIIHRDIKPDTTAITDCLFMADKRSVKLIDFGISKFTAETGDKLDAKGSPAYMPPELLGAGAGQQREQEQGGPDRSQAVRHRQDVHGYAGDIWSLGEFVRSLVEDWVRVANLIHVFLGVTLYALVTGGLPFDDADATELFHQIKNVNPTYPSHLPTTLQHLLSRMLEKDLHQRICIGEIWDDPWTNQEGEDRLVPYEENCVDLEEPTREEVERALNVYRASTFLAMSVVAKLKGKRRVSQDSSRRATSVDEGDSDKGASANTGSNGSSNGGAEGGRTPTPGTPTQASSLVSSPAESPGLEEAEDLKGLEGFAKWAKIVEKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MAI9</accession>
    <name>A0A2X0MAI9_9BASI</name>
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        <submittedName>
            <fullName evidence="2">BQ5605_C005g03342 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C005g03342</name>
        <name evidence="2" type="ORF">BQ5605_C005G03342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY74125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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            <begin position="308"/>
            <end position="378"/>
        </location>
    </feature>
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            <begin position="316"/>
            <end position="359"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY74125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="451" mass="48061" checksum="24A6438DDE957C25" modified="2018-09-12" version="1">MSLEVACQPEVPILGACGAVGAGGPVGAGTGGAGAGGIGLGAADAGANAFGGAAPQDLVASFGRELYSLSFQAGASGSHKKSFSSYNVTTSHSRASLVSAYTDSPITVSLELFDIASKAARPEAIPMSLFTPGASIKVKLGQTISLATTKDRSATLQLGHQLDHLLTFDEWQPASFLYAALMADIFKTTNTGEAFLQHFSRVAMRATSKSWPLWLEYDIVVRANFWTHLARSSMITAEHRCHRPTGDHLNYTASTCSLSTQLWSLSKAEGEAMVASVEEKRKEIFSTESSVTLTDVVRDAYSQVSAKPKKRLFSDPSGNSTPNIANRLSYSRPSVPQGASFQRDQPPNALRGSSDTNFRPSFDNGFRSTPPYDSRPLAANRSGNGSMFCIVCGLTSLDHPPFHLCRKFDSDAFTRSSSGALYPKSSNRQVCFAFNNGLHSSDHCDTGRGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MAJ6</accession>
    <name>A0A2X0MAJ6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C007g04626 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C007g04626</name>
        <name evidence="3" type="ORF">BQ5605_C007G04626</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pucciniomycotina</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY61936.1"/>
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            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
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            <begin position="19"/>
            <end position="302"/>
        </location>
    </feature>
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            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY61936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="302" mass="32960" checksum="1BEEE1FFC440B98D" modified="2018-09-12" version="1">MRSTFLVSLLSLIATAHTSSLGSGFRIQAAEPRLVISAPFADQVSPAPLDRSQSTVDRTALKTLSTPSSAEADHAPRVTYNDQDFYDPRRRGGRLLNRVNDWNGEPLNIIISARSSPDVLRESGLIAYSKSLGLRKECLDMHGGGAQYADLGDGGGFQPELFVLRQSDWPFVGSCVESVVGGNHFRAWKQNGTQANSGAWFLSASKEMDIRGRHKIIPDGYNIGRDLIVAKAIAGTRYRRRIWTAEVEWIEGLLEPGSEGEAVSRRDSESGHSVLIWSSLRAGVNHGIAQDGRIALLTVAEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MBK4</accession>
    <name>A0A2X0MBK4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C007g04584 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C007g04584</name>
        <name evidence="4" type="ORF">BQ5605_C007G04584</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY61665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MBK4"/>
    <dbReference type="STRING" id="796604.A0A2X0MBK4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="212"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="297"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="394"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="555"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="734"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="770"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="35"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="235"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="397"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="513"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="560"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="586"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="606"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="639"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="771"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="813"/>
            <end position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY61665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="832" mass="84998" checksum="948BF08ECD024C6B" modified="2018-09-12" version="1">MAAEVAPATSSDSDRGRGSAAGSVLELTPLAPAEATTSTVTSSSSSSSSSAAVSAPIPSWSSTTTASLASAARLPRSVSAVKEVQTPPGSDKKTSKVCDNYRLSPGKSTFLNEHPSRFTLPAESRPQAPISSRSSAADGLSGTDSAGPGAIDRIRWLRTPKDLSHVRCRFFAAGSCTAGAACSFSHEVVAPGTAKPVCKFFTQGNCKFAHKASRAGSEELETRRSSQSALRDAQAHAQMQAHASSADVVDPSTSPSATSSSTAIGSSPTQVPSSGLAKIFQSSGSTAQPWDMGAKSWSRVAGTTTSPQQSSAVMSTSPGSRWPPESEEGMSTTSSAMPATSADPTAAASSQLSSPGSTAIFISASSGLSQMSAKLANPSNNARSSVAVQVMLGQQARRMSSTSESLSPPRPAEPSHARGDFGMGMSPPLAMQSSSSIGAGTGAPTHSIFGTSPFSGGSRALFMPSSYDSNEDSSARSPPPRGGIMAEQMRRNSSRNGGNLFGIGASNSFGLEDNAEDGDDDETNDVFNSEGFLPSSLNELLTPDEVRRRASRAGMGLASPSFNPFNSQSVPADLMLSRGRPPMPPTTLSTSSSSSTRGWGALSASAEGTNPTASAFNPSKMTPSRSLLATSRDALGATGSPSSPSYLTSPNRNLYSSTFDPPTSNFGLRPPVKAGAELSPSLNPLPAPGSLPGGLAAGLSQLHLIPPLHTGDTPPSSLGTMTTAIGSPWRTMGGNLGLSKSPPPAAPTGAWGTTDRSVAQPTTIKTWANVASLSSSSSSPTTSARPSKVARGMSNGGHPVMGMASPLSKPEVMEDDSDERLEEDEIPFSMDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MCU0</accession>
    <name>A0A2X0MCU0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C008g05386 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C008g05386</name>
        <name evidence="1" type="ORF">BQ5605_C008G05386</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY80438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MCU0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY80438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="147" mass="16749" checksum="F5C2D6E4FF5E5574" modified="2018-09-12" version="1">MPSDSRLLQGSSSIVDASRRASSRIDVGHLPHSRPDIEVTTDFRQWNIFSGRGKVSTKRRSSQMRAINMRLITSFSDNRKSDTRREQECPRECSVWTIIVFNGAHSHRSLLHTGDSKSRLTRHRSNLFHLGPNGSCIVFLVSVMRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MCY6</accession>
    <name>A0A2X0MCY6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C004g02678 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C004g02678</name>
        <name evidence="4" type="ORF">BQ5605_C004G02678</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY66473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MCY6"/>
    <dbReference type="STRING" id="796604.A0A2X0MCY6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050648">
        <property type="entry name" value="F-box_LRR-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13382">
        <property type="entry name" value="MITOCHONDRIAL ATP SYNTHASE COUPLING FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13382:SF67">
        <property type="entry name" value="SCF E3 UBIQUITIN LIGASE COMPLEX F-BOX PROTEIN POF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="214"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="758"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="867"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="958"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="779"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="807"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="867"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="880"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="980"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1000"/>
            <end position="1009"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY66473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1070" mass="115802" checksum="474C84AD1C769AF8" modified="2018-09-12" version="1">MDTFAVLCPSLITAFSPSAIACLIADDRLAPARSALARSCQRRQTNFSLLFDPNTTTTMVSNGNSLGLASTSAHTLESQTSRSPSIASSSGLISDRDMVMHEGNSSLESEEQERDRDRDADPDVEEESADDSDFLDDDQAGGNSSSLSLAITSPAVATPRPNSLSTPWPFNQGSHGPSPLSTMSYAPISHPTVLTSSAPVTISSEAAPLTTTAPIPASSLPHEILLHILRLLPAASLSPALLVCKAWCQCGVELLWHKPSFTSLPSLSGMLQVIHSPDQTFPYPTFIRRLNFSTLHEEMTDKVLRKLLPCVRLERLTLAGCRTLGPESLIALLSNCTRLAALDLSDVVEVNDAVCQTIAKSSPKLQGLNLSGCKEVTDLGMETIAKRCKSLRRIKLRQVSLISDSSVILLSINCPLLLEVDLIACTRLTSLSLLQIFRTSPALRELSLQGCAEITEDAFPSSSMIHSLGSTREYNMPEDPDRSTSPLPPLVAMDGSLIPRPLPIDASPRLKPFEHLRYLDLTSVAQLTDDAVAGIVKYMPRIRNLILAKCSRLTDDAIHSISLLGKHLHYLHLGHVSNITDVAVTALARSCTRLRYIDLACCTRLTDLSVFELATNLPRLKRIGLVRVANITDEGIQALLQRTSLERIHLSYCENLSVLAIHHLLSCLPRLTHLSLTGVPSFRRADLQTWCRMPPSILTVFLVHFLHLQTFNSHQRTTFCVYSGKGVHELRRFLRNMHADMELEVAAAVWNQGLTNGTHVNDGQGMNVGAPGNAGGAGMPRAQAAAPRRIAFNPGSLQIPPHNPAARQARLLQQQQQQQQQQQQQQQQQQQQLPNIYQQQRLQQPHQHYQPQPGQMPLQLQQLQLHPAPPFHVGPIPPRNGSTQRSNGAQPAGGVPHPMMMNGQAFLGRPSSTPPHGANSLLSSTSNNNGAPDRAQIGAWAWDASRNTGSYLHAGSSNLTRAGSAGPSMMATNGGRDRTQVSTSNSSLAQQDRLRGLDISSMNRASTSADEGMGNVSLTSPSTRSRPRGATLTRGNYRGVDEDDGRGMDGGAGALTPGSATPSESDVEMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MDJ9</accession>
    <name>A0A2X0MDJ9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C009g05667 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C009g05667</name>
        <name evidence="2" type="ORF">BQ5605_C009G05667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY83976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MDJ9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY83976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="563" mass="60647" checksum="CA4EEE24AFFA6CAE" modified="2018-09-12" version="1">MPLVADAASTSGRLHYRPPPPRLDSLPYIHTPQVPSQFSSQPLPPPSARTRANHTPASSVASSVSSSRSGRALSTRTTSTAWSSVLDDGDDYSCDYTIYDDAPDEEDEDELYALYTAYEQHYDAHNAGAHDSTLVRSSHAMLSKPLGSTRPSASASAPESDECSERGDDQRSIASNSSSTNLATQRRGDGDVANLSRKRTKPKSKTNKPPKIDTEQDLLQQLARLSTAIDLCFCGRVAEEDSIYCGRECSRADALNALCGGQEGEPTTPLSAKHEAVATPIMGSRPTSFGSSDGVVSHYRRRVERKRAEERISQELWQSRNNSRTNLHSNPSVSSPRRLSGSSVASSASTSSSTGFKRSPRDLSQRKPVPTRDSTGSTQSKAPSLSSSLASPASSCCSTRNHSYAKTAEPASPRSYQQPKIIFPSPTRILPTRSVVRATGLTSNRALSTNFDEDLFASSLDATPTLATIHGRRAPLSDEEYGVPSLNRHSSDSLMDAAYGYGSVGLMMLQSDEDEDDDDEDDVVAGLSSGQKLKARVRAQMVPRPGHTRGKLSFDDVLNLLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MDT2</accession>
    <name>A0A2X0MDT2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C005g03371 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C005g03371</name>
        <name evidence="6" type="ORF">BQ5605_C005G03371</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calmodulin family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY74576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MDT2"/>
    <dbReference type="STRING" id="796604.A0A2X0MDT2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000006">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000398">
        <property type="entry name" value="Calmodulin-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="7"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="43"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="80"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="116"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY74576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="148" mass="16573" checksum="97F720DAC97D3525" modified="2018-09-12" version="1">MDQLSEEQVSEFKEAFSLFDKDGDGTITTRELGTVMRSLGQNPTEAELQDMITEVDADGNGQIDFPEFLTMMARKMKDTDSEEEILEAFKVFDKDGNGSISSAELKHVMTNLGEKLTEDEVAEMIREADADGDGQINYNEFCTMMMNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MGH9</accession>
    <name>A0A2X0MGH9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C009g05453 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C009g05453</name>
        <name evidence="2" type="ORF">BQ5605_C009G05453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY81082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MGH9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY81082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="309" mass="35010" checksum="1CFFE895473CC0C0" modified="2018-09-12" version="1">MSYDPHREGPGPQDLQILQVHSDRCPDGRPKYQIVSSLHPSAMPLRYPLLFSAGEDSYRHDEDEDDEEEEEENGAGERKRPTVSSKLFGIVSNAAKPDPDESVNAWGQHQCEAGPDCCMSFDATKDRWATLQLGRQLDHSLTFDKSQPASILFGLEIEPGGHCTHAKHRCRCRTRDHLKYTASAFPLSTKLWTSSKAELEAMFAFMEEKRKDNYLLNPPLPLPMSLRRSRLKRPGNPLDTIQRLSDVRGQLIRHRFRAASQCIVCGSTSLDHPPTQLCHEFDWDAFTRSSSGALYHESSKPQVCFAFNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MGM0</accession>
    <name>A0A2X0MGM0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C017g08479 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C017g08479</name>
        <name evidence="2" type="ORF">BQ5605_C017G08479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY20125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MGM0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY20125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="130" mass="14344" checksum="CFC71BD8A2A0BEB0" modified="2018-09-12" version="1">MNIFTIREALRNSSSYHHGLIPFPESNCWRHAQILSDRKNKGSTDHTPLPNGRGPLDGDRGIIGNAMNALKTANDELVEKGVVTSNEKMSIHFLVDMEEENLAGGAEMTDQEDCGPCHCRRVGGELRGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MH74</accession>
    <name>A0A2X0MH74_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyanate hydratase</fullName>
            <shortName evidence="3">Cyanase</shortName>
            <ecNumber evidence="3">4.2.1.104</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Cyanate hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Cyanate lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C009g05683</name>
        <name evidence="3" type="synonym">cyn1</name>
        <name evidence="5" type="ORF">BQ5605_C009G05683</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 3">Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>cyanate + hydrogencarbonate + 3 H(+) = NH4(+) + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:11120"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29195"/>
            <dbReference type="EC" id="4.2.1.104"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyanase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.104" evidence="3"/>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY84199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MH74"/>
    <dbReference type="STRING" id="796604.A0A2X0MH74"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008824">
        <property type="term" value="F:cyanate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00559">
        <property type="entry name" value="Cyanase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1160.10">
        <property type="entry name" value="Cyanate lyase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00535">
        <property type="entry name" value="Cyanate_hydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008076">
        <property type="entry name" value="Cyanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003712">
        <property type="entry name" value="Cyanate_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036581">
        <property type="entry name" value="Cyanate_lyase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00673">
        <property type="entry name" value="cynS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34186">
        <property type="entry name" value="CYANATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34186:SF2">
        <property type="entry name" value="CYANATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02560">
        <property type="entry name" value="Cyanate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001263">
        <property type="entry name" value="Cyanate_hydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01693">
        <property type="entry name" value="CYANASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01116">
        <property type="entry name" value="Cyanate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55234">
        <property type="entry name" value="Cyanase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyanate lyase C-terminal" evidence="4">
        <location>
            <begin position="90"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY84199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="162" mass="17979" checksum="9B2F59E594B5312F" modified="2018-09-12" version="1">MSASVINSLASANQSLFEAKAAKGLTFDQIAKDLGRNEVYVAAVFYGQAKPTKEDLEGLSKCLGVDHNVRVTKSKSLVSTMGEHFYPERGLGVTPPTDALLYRLYEIILVYGYPLKSVIHEKFGDGIMSAIDFRANVEKVNEEGADRVKLTFVGKWLPYKKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJ81</accession>
    <name>A0A2X0MJ81_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C034g11260 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C034g11260</name>
        <name evidence="1" type="ORF">BQ5605_C034G11260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000065">
        <property type="protein sequence ID" value="SGY98998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJ81"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY98998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="74" mass="8703" checksum="05015075137AE4B7" modified="2018-09-12" version="1">MINRSLHLARHNRREQILQESFPLLHERRLTFERPVLQSMHDALSIQSDHIDAFLRCTLKEALKDFDQGHGEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJG2</accession>
    <name>A0A2X0MJG2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C029g10670 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">BQ5605_C029g10686 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C029g10686</name>
        <name evidence="2" type="synonym">BQ5605_C029g10670</name>
        <name evidence="2" type="ORF">BQ5605_C029G10670</name>
        <name evidence="3" type="ORF">BQ5605_C029G10686</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ15423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ15612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJG2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ15423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ15612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="257" mass="28147" checksum="2FEDD73DD680DD06" modified="2018-09-12" version="1">MAFGQTDARVAADKRGPAANLELINSHNLGLEETGQSRRFTLAAYVYDWPSLQIRLDFFHILKSSLVYPSGSSSTFLQSSSRASTTRHPAPAAPLPDPAFSRSTSSDARTSRSYPVHADDRNGGRLFTPAARSARGRLSGAQLGLKKSASRAPSPSPAEAMQVMPISKEESRKGKGVQRFVSGKQAEEEEDWGKSASDVSPSSGLSESSAERRQVQDIFAGKQRIQGMILSSDPKRDQRRKRYLRHRTLVRSDSQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MK03</accession>
    <name>A0A2X0MK03_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ornithine carbamoyltransferase</fullName>
            <ecNumber evidence="3">2.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C010g06184</name>
        <name evidence="11" type="ORF">BQ5605_C010G06184</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="3"/>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MK03"/>
    <dbReference type="STRING" id="796604.A0A2X0MK03"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019240">
        <property type="term" value="P:citrulline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1370:FF:000009">
        <property type="entry name" value="Ornithine carbamoyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001986">
        <property type="entry name" value="PRK00779.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45753">
        <property type="entry name" value="ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45753:SF3">
        <property type="entry name" value="ORNITHINE TRANSCARBAMYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/ornithine carbamoyltransferase carbamoyl-P binding" evidence="10">
        <location>
            <begin position="129"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Aspartate/ornithine carbamoyltransferase Asp/Orn-binding" evidence="9">
        <location>
            <begin position="252"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="88"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY14443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="417" mass="45010" checksum="D85671C62F47BBA8" modified="2018-09-12" version="1">MLSTHLARHSKSLLLARPPTLPVLGLGHRRLSTAPAPTLHPSESGLRPPHLLTLADLSVGQIQNLISSAIAFKKHYKKNAIPLAGRIESTSSSSSSSSSGAAASSPSSSPIDAYGTGGNKEVEHSRISLAEKSLDHKTVALMFSKRSTRTRVASESAVHMLGGHPMFLGAGDIQLGVNESLYDTSRVVSSMVDGIMARVGHHSEVETLAANSSVPVINALSHLYHPTQILADLQTLLELHGPFSPYLSSLSGLTVAWIGDSNNILNEMMVTYPRLGINLQVATPKGYELEPEVLARVKSGLESSGSGGHGKLVHTNSPEEAVKNADVVVTDTWISMGQEEEAAKRLKDFKGYQITNDLLKRGGANKDAVFMHCLPRHEYEVDDEVFYGPKSIVFQEAENRKWTILAVFDAFIGKWKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKC8</accession>
    <name>A0A2X0MKC8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C021g09333 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C021g09333</name>
        <name evidence="2" type="ORF">BQ5605_C021G09333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000083">
        <property type="protein sequence ID" value="SGZ21094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MKC8"/>
    <dbReference type="STRING" id="796604.A0A2X0MKC8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08065">
        <property type="entry name" value="MPN_eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027524">
        <property type="entry name" value="eIF3h"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045810">
        <property type="entry name" value="eIF3h_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19445">
        <property type="entry name" value="eIF3h_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eIF3h C-terminal" evidence="1">
        <location>
            <begin position="221"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ21094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="433" mass="44593" checksum="86A943EEC3980F66" modified="2018-09-12" version="1">MAPKRLADIAAPAPEVVAEPVAEVKKESAKQRARIDKGLAETRVESVTVDGLTLMKIIKHAREAHQVIPAPQGTSNATVSFSPAVGQLLGIDSEGSLRVSNAFALPAGALGGSSSDSEGENRGLKAASKYSAAVLSRMIDLNADGSIVGFYTSTNNGQTLAISGFVEALIGAQMTGGGVGSGLGKATPVGRAAATKTNLVPGQGAKNGKGIALVYDVASAAQGHVGLKAYRLSAAFVEAYRAGKFDTQSLIDHKLVPSNILEEVPVTVHSSSLLTAFLSTLVTPSSSSANGASQSSSVPLDPLTTYSQLSLPTSSTSSNPSPLTTPLTALLSALETHQAHLSTLSFQSRQLGRDRARLESNPAVVRRRIENEQRAKEGLPALALLPEELALQEPSRLETMCALNAVQGAVKVLNQATGTGLVRSYGAKAGTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKI6</accession>
    <name>A0A2X0MKI6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C021g09393 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C021g09393</name>
        <name evidence="2" type="ORF">BQ5605_C021G09393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000083">
        <property type="protein sequence ID" value="SGZ21634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MKI6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ21634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="354" mass="37508" checksum="DB15B6A3937F81B0" modified="2018-09-12" version="1">MDASRGATINGRPVREPAEAARWIEGVIKGQMEKAFSTQDKQLLMQANAKLIRHATLGMHIGVLVGPAYIFRQRFTAGWRAATKASAGGANAATTTTPPRLFYPTKASDPTGRGAANGPQAAKSKMTYIGRGVGLGLLGGFIGSQIGVLTGTRAAQNLIKDSGQEPHIAAKLKKAMDQAALEIKQGSTGLETASNPLLKRSNPFGSVSSEGSSAIDGPPGGMVEVAHDDAAADDRDAFLSQDGSVAPSRRAPMSRSADPNGAPSRWEELRKSRAAPPSSWDTIRESSSRRDVPSAAPADVSSGDGQNQGQLPSSESSAADREARRRKFEELMEQERRGVDNLGSDQSFDERKWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLB6</accession>
    <name>A0A2X0MLB6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01655 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01655</name>
        <name evidence="2" type="ORF">BQ5605_C002G01655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY34585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MLB6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY34585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="268" mass="28086" checksum="1E0B77FA4C2D7B1E" modified="2018-09-12" version="1">MAAGPPCPELDSRNKYSDRLPPLLPHLLSTASSHTLTVSVPTRACCVAASYLFSLVRLATSLDLSRLLGAHAVLSLLTNLSNAPVWNLPLSLYGLVVVSHHADDGGDSVRQFAALYAFSFFLDALWLLSNSTYTSTWFFIVVNFLLKPVTLLSTLGQLRLRGHATFSLPGGFSLPGGNDQFGGNGGFPPARTGANETMWQAPSGAGGYHERTFSQEERGVPSPSTAAAAPTTAPPSASRLVGPVAVGGNAGGQGYQGRSEGGGYHTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MM17</accession>
    <name>A0A2X0MM17_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g01897 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C003g01897</name>
        <name evidence="1" type="ORF">BQ5605_C003G01897</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY37838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MM17"/>
    <dbReference type="STRING" id="796604.A0A2X0MM17"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03062">
        <property type="entry name" value="TRX_Fd_Sucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902:SF14">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY37838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="441" mass="48048" checksum="9F5F58063750345F" modified="2018-09-12" version="1">MSPSTFIPRPALSSAASAALTSHGVPLKTLEEACKGCAHDDSDDLETYPKTFDVDLDSEMLGSVNYYGRQILIATGKSDWDREVTDDPESLPGLLKSAYELATTCSDGGRKGTGLLNKTFQKPKIVKGDDAPLPEGSVYKGVYPSIVAPPPLKASTSAVAPDSTETAEVVEPPRLSILTGSFLSNSHEDDDHSVIVLPDFKIVHHVSAKASSVKAFVGSHLHPSVPRPGLSSLTSSKTRSYPLPYRALVLICSHKRRDKRCHIAAPLLINQFHHHLAEHDLEMDERGDSLGSSDERPLEAWPLEERESKMDEALKGVRIGEGRVGVFKCSHIGGHRYAGNVIIYLPNGTSIWYGRVTPRDVGAIVQTTLIEGKVIPELLRGGLGLAGKSGFEEGIESGLRLFWSRNERYFRKEKIETDVDKIDIIGQLLLGPELTVLLVDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MMB3</accession>
    <name>A0A2X0MMB3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA pseudouridine synthase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">tRNA pseudouridylate synthase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">tRNA-uridine isomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">BQ5605_C012g07039</name>
        <name evidence="18" type="ORF">BQ5605_C012G07039</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Formation of pseudouridine at positions 27 and 28 in the anticodon stem and loop of transfer RNAs; at positions 34 and 36 of intron-containing precursor tRNA(Ile) and at position 35 in the intron-containing tRNA(Tyr). Catalyzes pseudouridylation at position 44 in U2 snRNA. Also catalyzes pseudouridylation of mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a uridine in tRNA = a pseudouridine in tRNA</text>
            <dbReference type="Rhea" id="RHEA:54572"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13934"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine in snRNA = pseudouridine in snRNA</text>
            <dbReference type="Rhea" id="RHEA:51124"/>
            <dbReference type="Rhea" id="RHEA-COMP:12891"/>
            <dbReference type="Rhea" id="RHEA-COMP:12892"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MMB3"/>
    <dbReference type="STRING" id="796604.A0A2X0MMB3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02568">
        <property type="entry name" value="PseudoU_synth_PUS1_PUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.580:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.660:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041708">
        <property type="entry name" value="PUS1/PUS2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF4">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="17">
        <location>
            <begin position="341"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="556"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="43"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="603"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="14">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="SGY16947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="613" mass="66659" checksum="4A29A21404E3CCC5" modified="2018-09-12" version="1">MSDPSTSGGNKRDAPTNSTGDGGAGNDGNGSKRARTDGDGRGGKGGGQGGGRGGGGRGGRGGGGRGGGRGGKAGTYRGKRPGDDNRSWGGRNTGAAVGKMRSWGPKEGTGEEKAEGNEENKERLPKKKVAVFFGYNGQGYKGSQINPGEATTEGELWQAFIKAGCVSADNADDYRKVSLQRAARTDAGVHAAVNIITLKLILAPADKPEEQRVEDWINSLLPPTIRVWNIVRVQAGFEPRKVCDQRNYEYSMPTHVFLGPKPSSNLGKWLEQNREEFLKTEAEAVEGSVERTLPACVQAAKTATADFWATQSSENKFLEDVAAKKTWRITPELLNAARAFIKAYEGSHNFHNYTVASTTDKSEPRDAGGKRAKKGGPQDVASMRVLRSLSISDPFIVNGVEYVSVDLLGQSFMLHQIRKMIGLLILAVRSGAPPSLIASTFTPQRIHIPKAPALGLLLLEPQYLEYNKRILEHNVKINALDKLDEAQKTAQRREQIGVVEQTDQVNAFKRDEIYKVMWEVEEKEGVFAKWVNYVDVFEGRDFAYLNPEGTVPECAVYKPGERSDQPRRRARKQVVENGEGAEDALEQAKGEGEEDVQPPSDDERADGEDGGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MMK8</accession>
    <name>A0A2X0MMK8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C021g09229 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C021g09229</name>
        <name evidence="2" type="ORF">BQ5605_C021G09229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000083">
        <property type="protein sequence ID" value="SGZ19882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MMK8"/>
    <dbReference type="STRING" id="796604.A0A2X0MMK8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ19882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="761" mass="82597" checksum="B4A17AD8DC263FAA" modified="2018-09-12" version="1">MASSNETTPIVSSNSRPPTLTRLLATCAPSSWFLPPPHHDGVCHSTATRVQAEAGTTAYDCVARLGGLKWDSPASPGARVLGSFFDILEQHPSLLDLFREELDAINNAPRSRMPRKSEHEVEISFLRLLFGGLESATAALLNHYAAITEAVGASSASASTSATRPRYSVQLGEPQRALRTQGDAVVYIELEAGNVVSSISIEYKRDNVHHSLAKVRQEGLSHIPILDHGAPVPLQKLEEEESNGADAVATKAIIQCVSSESRFFLLLSVPFFQIGELVQHQSTHAATASDPVASTSAASASISAATAYSPAPPLKARYSLILQELARWVEPSPTTMNPDAAETLGADLPRRSLIVSFIALAFTAVIEVPKPDQAVIDTLLNPQFQPPNLPRRRSDPDLDPNYEPSPRVQKASKTSIEATGARRSGRLAGQPPRAQTKDSNRPVTPPISVGLQSDPSFDPLTPVTRIFSSPPASTDWSPATSPLSGSGLPSKSITIVQDRGFVIKASLSSAYWSTMSYTGTSRVELVEIGFDIVSSVPSDSPLASRLPSKPSPASDFIRGLHLSDVVLRWLSENPREELKDDRIPLELLDRFEPTADLRLEKEVGSGSTAGGWLAKVVQVNRPLCSSAKAEAPLVDHPAPNTTYFLKLVTCRHVGSVIRETLFYQHVLPHLPEHLRKHIPQYHGTYRRTNGNGYAMVLENVGKPMNEADFYGSPGESWEIEAAFRELGIIHNDVRAGNVLVRPNNGPLCFVDWGRSYLKLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MMP7</accession>
    <name>A0A2X0MMP7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C026g10147 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C026g10147</name>
        <name evidence="3" type="ORF">BQ5605_C026G10147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ27626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MMP7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="408"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ27626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="795" mass="87846" checksum="4F175488BECE96FA" modified="2018-09-12" version="1">MMSREFGVCVWWWWGESRTRRRDSSVEGIEGRPRFDSWSSRSSSFVDHFSGSLLNPLRWDCSNFWRPDTNTVFVSDDANFDESSFELHRGNSDDADLREDSPTTLFGDPPTGSLDIDGDDAVEQDFSLDGAGRAQAPGTDDRATAPIAARRAFAPDGDSRDNTSPVGRARAPDREYTPAAPGCERAPGDRVQHSNGQELTPIVPTRRAPAPVVSNGRAPAPVAPNGRAPAPVAGDGGAPPPVASRRPSPFLDDDADNDPPDPNPIPDGYEPVVPTTERTSELAERWGAPAGSRRRGGAEQQAMFVDLGTILGDVIPLNELPEWEQVLSVVVNLEECNGWTNLSSIVQGSTEGICGIEELEAYQVWTGSPDEPTYKQAMAGEDREDWSISLMTEYSILNGMNTWDKEATDPPPGVRAIPTKVVLVRKRNDKGDIIKYKARIVARGDLQNHHGETFSPTARIASIRMINVIAHVKGYRRLQFNVNSAYLHGHITEPLWIKLPDGSTHRLRKSLYGLKQSGREWNKVLHAALVDRGFKRMEEDFGVYRRVRNIGGVDRTTLLAIYVDDGLLAGDDDLEGFLSEFDQQFKLKRGEVELFLGMKIATDDASGIMTIDQCHQIETILNNHGFANASAVATPTSDSDQHSDGGCTRPDISYAVTQLSRHCADPKPEHFRQMRRVLRYLRGTINRRLEYNRHLGIDVTLYCDSVHTAEKLGRRSISGYTVIITGSAITWASKRRVSVATSSVQVEYQALSAAARETLGTCGIGKLARAWRGAGWRQMAVWRIDWTQRSSINAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MMZ9</accession>
    <name>A0A2X0MMZ9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein transport protein SFT2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C003g02167</name>
        <name evidence="11" type="ORF">BQ5605_C003G02167</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Nonessential protein required for the fusion of transport vesicles derived from the endocytic pathway with the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Golgi apparatus membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the SFT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MMZ9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137:SF6">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="510"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="539"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Helitron helicase-like" evidence="10">
        <location>
            <begin position="268"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY39197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="619" mass="69158" checksum="1336A1E1C4B4E677" modified="2018-09-12" version="1">MAECAHCKARHWECKGRTGHLSTCCSQGKVQLPPLRPNPEYRQLLEGSDTVVQQVERAVFTALAAHFDQTRLGTQGPRMFRIFDALTIDSAHSRRPESCRQSAPNLTQNMAHLPGRGRQHSTWTRRRRQSHTKINFDKLNSTLRTGNLFLAETDAPTTFLRRAPKWRCLSAIPTPTLEIVDRKTLFSRCTVIEVPMVGPSTKSLARSIRLRCLSVTHYSSPQRKIASTSTLLFARSTKLGHSLPKDRDEEEGDAENGDGELSRSQSFAYYLHKRDEYFSIPHCTQRAFLAFVMTDTPRSRPIDSTYLQLDQENLRLTTGQGIISLAPDQVGCSVILGSTFKNRPRENTQRYQDAMACVVKYGKPSLFITVTCNPEWPEIKAALGPNDQACNRPELIARAFEAKLNRLCDDDVFGNKQRAGCLWRRTVSLLYFVFRVHASRRACTTDLKFESTSRLRIIACGSLPDKMALASVQGAWNTLSGSEAGQATSQLVQTDDSAFKFLDLTRTQRLYGFGFCLVAGCALAVVGAILFTLGQVTLFATFYVLGVIISLVGTGFLVGFKMMMDPVRIWAAGTNVVYIKPAHPRSLVLSSSLRSPFGSRYTLSYIPYARALAKKLNPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPD8</accession>
    <name>A0A2X0MPD8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C023g09640 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C023g09640</name>
        <name evidence="2" type="ORF">BQ5605_C023G09640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ23818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MPD8"/>
    <dbReference type="STRING" id="796604.A0A2X0MPD8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40132">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40132:SF1">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ23818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="425" mass="49672" checksum="81FEED069BA4380A" modified="2018-09-12" version="1">MSPTSLSPPESSSSSSVPSKLPSSTTTTTSLSSIVSNLFQRTSLNLTTSSTDPYSDKMIASLLLAEASRPSTNTSSRLLGMRGELEKEAIRKPNKRFLKGVLGDVEAHNRRVISAQRERERFEREGGRETVVDGRDFRSTERRSGEVEEDEEEDDDEQERRYRRSGQEKETDRDRDRLRGRDRQRVNKVRHRDRDKDGNPGDEGRHRSSRRSEHDHEQARSKRRRDDDHTNHRTSKSKQRDENRQHRYRRDHDEHQDRHRERLDRHRPREDEPSNDPASNDAGPIAHTTVGVPSKMDKYFAPDYDPLFDVSVENDLTDPTTRLIAPGAFDEWDTMLRTIKEKEERKREEKEGRRRRKERDKEERRRERRRRRGESVSSSDEGPGGEDERRQGKKIKLGKGKALMEVEYTKVGGTREWDRGKEHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQ82</accession>
    <name>A0A2X0MQ82_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sorting nexin MVP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C001g00272</name>
        <name evidence="11" type="ORF">BQ5605_C001G00272</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY45309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQ82"/>
    <dbReference type="STRING" id="796604.A0A2X0MQ82"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028662">
        <property type="entry name" value="SNX8/Mvp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045734">
        <property type="entry name" value="Snx8_BAR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47554">
        <property type="entry name" value="SORTING NEXIN MVP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47554:SF1">
        <property type="entry name" value="SORTING NEXIN MVP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19566">
        <property type="entry name" value="Snx8_BAR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="10">
        <location>
            <begin position="266"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="23"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="175"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY45309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="724" mass="80614" checksum="7DA49967E1AFFDE5" modified="2018-09-12" version="1">MSGPLGNGDGGGDLSTVRPISARQGSWADSSPWGNTTTTGTPTARRTTGSTHIHEEPPSLLPLLHDSNVPPLYLHAWRGAQPIRDTVSLGAVMRVLSSGGIKQASIDKASALQSIVSLVTPTSGIITKQQFYTSLVLLAHAQLHREISLQVVARAIEVGSLPIPTLSSSSASSAAVYSAPSSPTSMTSPPDYRRSTSMSSTNDDPWGTGTAGGSGAVKASGGSQLHSSMGASRPTFPPVDEDDDHGHAFGENLLGGTSLGEWVLGKQQKVEVRMRDELQGLVFKHTIWFIATEVSTAQHPTHPKFALCFKLIRFHATCSQRGVIVERRYSDFVWLHDCLVRRYPFRLLPVLPPKQVHIPGYIAIDELFLERRRRGLERFLVALLNHPTLKHDHLVRIFHNEQSELSAWRKSNPISLEEESTSRILTSEEEMSVPSDLEERLTNLRARIIPLVEHWTRVTTTIDRIAHRRQNQAAEYERMTEALSGAVECERTGWRPVECENVEADVDKVARGLRAVAGRMRQGADEQLETTVEELKRVRGSFAAGRGASLLELMASFLTCVAPRAVRQHEGAVHAVRSPLGRYRRQTQTARRDQHEEGELGRSRRFEIGWSISLIAASLDDHVRQLEVLRDAATPLAPAEFDKLSHSISTDQRSIELLLRRRSFVRWCMWQEVLWMFRSTSLLSTATRVWVTHEVARAEHLRIRWEELQEGWETVLTRSAAEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQZ1</accession>
    <name>A0A2X0MQZ1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C011g06369 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">BQ5605_C026g10194 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C026g10194</name>
        <name evidence="1" type="synonym">BQ5605_C011g06369</name>
        <name evidence="1" type="ORF">BQ5605_C011G06369</name>
        <name evidence="2" type="ORF">BQ5605_C026G10194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ27809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQZ1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY12039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ27809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="43" mass="5062" checksum="FC36F6BA2039A934" modified="2018-09-12" version="1">MVWWKGVSWASRVEQVLCELDAIRQVACTIGDRKFSCWSRGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MRL7</accession>
    <name>A0A2X0MRL7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP synthase subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BQ5605_C027g10415</name>
        <name evidence="16" type="ORF">BQ5605_C027G10415</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MRL7"/>
    <dbReference type="STRING" id="796604.A0A2X0MRL7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18116">
        <property type="entry name" value="ATP-synt_F1_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1-ATPase_alpha_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.150.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004039">
        <property type="entry name" value="ATP synthase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="entry name" value="ATP synthase alpha/beta chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a_nt-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009884">
        <property type="entry name" value="PRK13343.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082:SF2">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039088">
        <property type="entry name" value="F_ATPase_subunit_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="15">
        <location>
            <begin position="53"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="13">
        <location>
            <begin position="175"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase alpha subunit C-terminal" evidence="14">
        <location>
            <begin position="405"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SGZ28700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="536" mass="57546" checksum="444DCF0B35D2FFE8" modified="2018-09-12" version="1">MLSRAAFSVRAATRTSAVNGLRSYATAKPAASEVASILESRISSSPGGADVLENGLVLTIGDGIARVYGLRNVQAEEMVEFSSGIRGMCLNLEADNVGVTIFGNDRLIKEGDSVKRTGSIVDLPVGPGMLGRVVDALGNPIDGKGPIKSTERRRAQVKAPGVLPRQSVSEPMLTGLKSVDAMVPIGRGQRELIIGDRQTGKTAVAIDTILNQKKWNDGADESKKLYCVYVAVGQKRSTVAQLVQTLEENGALKYSVVVAATASEAAPLQYLAPFSATAIGEWFRDNGKHALIIFDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLSDKHGGGSLTALPIIETQGGDVSAYIPTNVISITDGQIFLEAELFFKGIRPAINVGLSVSRVGSAAQSKIMKAVAGSLKLYLAQYRDVAAFAQFGSDLDASTRFLLNRGVRLTELLKQGQYQPMAIELQVPIVYAGVNGLLDRVQVNDIGKWETSFIDHLKSSQQSLLDEVSKGKMTPEIDAQLKKVVSDHVTSFVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MS01</accession>
    <name>A0A2X0MS01_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C142g13433 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C142g13433</name>
        <name evidence="4" type="ORF">BQ5605_C142G13433</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000141">
        <property type="protein sequence ID" value="SGZ35661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MS01"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="88"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ35661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="966" mass="107176" checksum="0613F89254A61977" modified="2018-09-12" version="1">MGEQGTRLDEGLYLLDADHSKCQHIALLSRSQSSVPLLTLHRCLGHLAPSSIQKMVAAGLLEGLRAGYSDEEVEKFVCNACLSAKGHRLPFPDSDSHSSERLGLVHSDVLSLPERSLTGKRYLVTFLDDYSRKLWAYAIGHKSEVFSVFKTWLAEVELETGATLKVLRTDNGGEYCSRAFTDFCKRVNRSIVEGILALLADAHLPKTFWEEAAAYFVYCKNLVQHSALDKATPNSVWQGGRTTASALHPFGCAAWLTVAPELRSKLDPKAVRVLFTGYDLASKAFRFYDTTTKKVTLGRNATFVDTEFPGLCGDSAEPDDDTHFASAPFADPQTTVKSWTPLYSADPLDLIGSQPQAALDPMDTQPPDFSTYREPASAEESPDELDLIGRHSRDESPDEIDFLTRHHRAFIATDDDTSDTEAIEPVKSITSDPQTWREAMSGDKREVWAKAAADEFNSMRDNFKVFTIDDRSTVPAGATIVSSKFVWKTKRNALGEITGHKARLVAQGNRQRDGIDFTETFAPVARFSSIRSLLALAATNGLHVHQADIDKAYLHGDLDHDIWMTAPRGFDLPGDKVLRLRRSIYGLKQAGRIWNRHIDASLRDLGYTATGTDHCVYSRLDNRQRPHYIALYVDDLLMISPDLAEIERVISGLEQRYGVKRLGPAEYILGIQIRRLDDGSIALSQERYIMDVLARFHFDTTTRGTTVPMTPGLSLTAIPGQATERIRSWYLQAIGSLLYISLGTRPDIAFAVSYLARFANNPGHRHWIAVKHIFRYLRATYRDELVYARGEARITGVVGYSDANWGACVDTSISTMGYVFYIAGSAVSWSSKRQSRVADSTTDAEYLALSHAGKEGIYLSQLLEELHVQPVAPAHIFTDNEAAAAVARDPVRVTGTRHIRLREHFVRDMVNRGDISLSHVGTSDMVADIFTKALGPKVFSTHCYALGLRTRHPRLGSASHSRGGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MV25</accession>
    <name>A0A2X0MV25_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g01989 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g01989</name>
        <name evidence="2" type="ORF">BQ5605_C003G01989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY38266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MV25"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY38266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="139" mass="15226" checksum="88257F7D94D94955" modified="2018-09-12" version="1">MPRLAHVPPTTGDWTFVNAAHALRATPQPFTPPVVHQNRFAALETDDSNNATIDMSNNGFDTPSDMSRPPFSLTGIVGGDDDAYTRESERGASAGAAAVNRRQPRRIRGCRARSKSSTMDYGGQRDRIKRGREAIQRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MVM1</accession>
    <name>A0A2X0MVM1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g02219 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C003g02219</name>
        <name evidence="1" type="ORF">BQ5605_C003G02219</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MVM1"/>
    <dbReference type="STRING" id="796604.A0A2X0MVM1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY39435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="73" mass="8291" checksum="546A13961F71F9EE" modified="2018-09-12" version="1">MLNLMMYIGIHRDKKENRVIASVSLGAERTFIMTHAPPAASSRRDEAVLKSTTILHYPDQGEEDRSVLLRSHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MZE0</accession>
    <name>A0A2X0MZE0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C008g05195 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C008g05195</name>
        <name evidence="3" type="ORF">BQ5605_C008G05195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1353"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="689"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="787"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="853"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1135"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="475"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="689"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="732"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="921"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="944"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="961"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="975"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1210"/>
            <end position="1219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY79679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1397" mass="150820" checksum="DD72EA15BBD07946" modified="2018-09-12" version="1">MSPSPGEVTSTPPPLPTWEDGRSLLALKGARQSSPARSCDDDQHDGGQSPATLRRTTPQQYPALSNGESSVGNGATLNSTIGMDRALIGVNDEAIDHHVPSPPPSPPHLAVGVHGHSHGGDDEDDDGDQLRKTRTSDTASISSAPVMTTMSAEPRPSPSLLGTETHHDGATFTGSRRAHTLPSPPPKTTEAFVHHRRADTVPILLQAPPGPLPFHSLGTPPLDNPGSTGTSSIDRHAHAPIASTSLTNMDNRRESRRASLFEPAFYSTSSACSPSLDDSAATHPSANGVATTSFGRATIGKLTTEADLSRPSSAGSAFDNPSPRHRIDKKGKSRMKSDDPLQYSGWGTQFESVDDPLDPLSQMFGTSRSREPSSNVSLATSRTTETATTAATTMTSASLDPSVQALLDAVDLGAARKLVQDLEAQLPVGTPTMGRSLPPASSAVTASTSVKFATTPSSSPPIAPPPLVIHAPAKGTTRRLSSSAPRRSSLHGLDSMGKDSPRRKSFSVGKGFGRQPSTSLPTSTSGIIAPNLAIPPATPQESNFAVAAGNNVEQRTIDERIAMGASGRFFEDQISKVQLQLSPATHRRAQNCVKYLSLRYRPLGAQRPLADDPPFPNLLAVSRWRLAKQQIESSRSVDGSVDGRRYRGSSGAFIDTSKKVPPYGKRRNEKPGVWEVYPDDILDYIKAGGKLEDPAKEDPEERSNRVSILMPPTSPHSRSLGRHSMLPFPRTRSLTPDQGGSLTSINRPSLSRVREDSYGSVRHAKVRSIDRFLGFGTPSDPIIASSSGLLASPPRTHPGRFSGSLNDDFTPGYDEDHTMMETLAAPNGNRNANSYPSPHRSRLTSSITRRFEKMRGRGHAPSSSMNGLDWESSDGGFGPLQPPHRKGYYSVGPSLPGTPEGSDHELGLSASAGPRISPKRSLLPSANLNLSNSTWKKGTASLRRNRDRDGERRGKEPFSPLFQSQSRLRSNGTDSGHRSSGGDDSKAVWKKDSPLSRSRIASDGLRLYSPTSGLNLLDGEGKRRRTFESYSEDDTEALKNDSKEVLDVSEERFAQLMQSTKAAYSDLDQIESFISTVPLTIKINLDGLVRLSSQTLKKTGIQITAQAPRLPASVIQSIVRLDSIEVERGQNLTSVKAEGRPSTCEPLHGIKEGRPSHVRFASTGSTDSSESDSDSETTSSSSDDTGNRSDDERELDTVYTLPRRRKSSLPPNPSTPSLPPRAATDMVAPFDPLSRTVQGRTRSATLAVPSSRPRVHPTFDPLIDLQTPVDPIKSLELGLQKFEKTFKIMDDAAEKALEEQRLLNVEIEELVLESRQVMKDYDSADHRFIQPLQEQVHRVLQLLDKPSSSYDGLWIALSIAVGVLLCLARFVAMVISFVRSVIKYPFLKVRRVVSPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N250</accession>
    <name>A0A2X0N250_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C036g11517 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C036g11517</name>
        <name evidence="2" type="ORF">BQ5605_C036G11517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000063">
        <property type="protein sequence ID" value="SGY95811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N250"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY95811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="123" mass="14380" checksum="09DAFFBFA6E9A043" modified="2018-09-12" version="1">MLRQSVDLLHHQLQPTDIQKLGSQSSHPIVIPPTIPVLGFHRLRYLFNNSYTTNVVLRLAATRTTIPLVLLRLEPLSFRYDSREWSGESKSSEVRPIRKQQKKKRGPCRPGWRWLEDRVQLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N2E0</accession>
    <name>A0A2X0N2E0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C035g11408 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C035g11408</name>
        <name evidence="3" type="ORF">BQ5605_C035G11408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000064">
        <property type="protein sequence ID" value="SGY97498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N2E0"/>
    <dbReference type="STRING" id="796604.A0A2X0N2E0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013920">
        <property type="entry name" value="DUF1774_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37992:SF1">
        <property type="entry name" value="DUF1774-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37992">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY97498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="386" mass="41484" checksum="9A975C1BA1A003C7" modified="2018-09-12" version="1">MALRLSSSGTLDRIEPPQPFVALPPRDPTASSDPSLSDPISASVALPAASTTTTTTAAAAPALDAKMPSSTATPVALSPDEAALATQQRRFARSQIALPISLLVFIIASLLSSLVAKPTLAEVSELYLTVMTPATKLIGLYWLVIASLLVGQLFISGGLTVIWLGTHSQAILLGVGPAGSQPILVKGVGLRLAFVNLLMSAWIGCFVLRFFLVAQIILLVVLIMVISIWATLLRFPPVASRPFYFVFIHMPIRMLLAILLQVDVWQGGLLALRYYRHPAKSGHRPSWEAAHSTHGWIMFAIIIVVALINAAEVFYLRDFVFAASCNYLVVAETIQSEGKSAQIWIALVLAAVMVGVSLLSSVGWSMIKHDREGAIRLADEEEVARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-11-27" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N2X2</accession>
    <name>A0A2X0N2X2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C033g11139 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C033g11139</name>
        <name evidence="1" type="ORF">BQ5605_C033G11139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000066">
        <property type="protein sequence ID" value="SGZ01337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N2X2"/>
    <dbReference type="STRING" id="796604.A0A2X0N2X2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ01337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="267" mass="29797" checksum="479D7392D4A38DFC" modified="2018-09-12" version="1">MTFYPGIDHCNVKQSACREDVLDAYIFYQTKLNDVLAKESNESAPNLDVKRAFAAGGSAGGTSTLCLPIDVHNYNNLKKHLEAKIVQPRAVVPAYPACLKDGYQDNPTSALEENLAKDNPEGWKAVQKLFVGRVSCSFKTNSMPLPDDHPRCIWVNSDVKYNCHNSFLWGNPPYPAAANFLNFFGPWFPPTFMLAAEGDSLIPVQHSYDVVEALKKHDVETRVGIGKNAEHGFTEWNPKLWPEGADWWTPIEEGLNWAIAKTVDAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N325</accession>
    <name>A0A2X0N325_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C033g11189 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C033g11189</name>
        <name evidence="6" type="ORF">BQ5605_C033G11189</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000066">
        <property type="protein sequence ID" value="SGZ02131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N325"/>
    <dbReference type="STRING" id="796604.A0A2X0N325"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF392">
        <property type="entry name" value="NEPHROCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="361"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="667"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="624"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="364"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="385"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="689"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="705"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGZ02131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="965" mass="105505" checksum="DABCE85DAE1BC0B2" modified="2018-09-12" version="1">MTDSTRSRTPSRLARMESSDSSCFSARGPSAPSTPLRTPLTSSTRGAGAIKSGAGASASPQVKVALAAMRNKQRNSARSGQTASSTSALPTNSGSKAIASSSSLASSSSSMMMGVEQYDAYSTPPRRAVQSGNDFEEDDAVQEFRFGQRTIAVRAEQRQTAQEREEDVEEEEEVVLDWGTRAKSTRDVVEGAKRTGVLVLASRELKSIPLLVYEALMSKASVYHPTRQRTRASGSKGKDPAPIIDFSTSYDDRKTAWYEQRELRSLSVANNDIKEIQEMIAGFEELETLDLHNNYLVSLPTSLAQLTNLTSLNLSANKLTTFPIQLLALHSLTSLNLASNQLTHLWPVDWRLHLSDTLHPPSLSPTATPESSPEQSGGHVLGFWSTPAPSATPDSPSSTDTPFKAPLTRLTELILSDNPFSPDVFQDPGWSFPSKLRELHLADSGLVETSFPALVFGKLAHLQELILAGADILSSPFHLEDVVDEESELFPSLTRLDLSRNSIDSLLHLEAFFVRHVKRPIEYVGLEKSIMNLVKAKGRPNGDVEGREEVRIVLHDNPMREEQVRRRALFGRPAASEGFKEGVEVELANAAPTKNTVKRRVVKEQWEIDAENGLLTEGGRRRARIEAMRRAKEEEEMRKEVERRGEKVEVDETGTIVGALLGLKVKDGDEKGQEAAVGREQAQEEEAPPPEYSPTPTPVAPILTPEAPGAAAPAEASKDDPAIQLVSLAHKVISSTIDLSSKSLETLPTPLGSPPSHLSSPSSLVLSRNQFRSLSTSALSAWTWANTLRSLDLSYNRLTVFTPDSPLLNLTSLNLSNNQLTELDPNLASSTSNLTSLDLSRNRLTSDSSLSPFFRLNSSTPSSLTTLNLSGNSLSSLPALIELATTIRGPSSLDQARSKHNLSLRSLDLRDNDLLKLETKLGWLPLGLEMWLSGNRFRVPRREVYDSAQGAKEIVGWLRERIAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N5K4</accession>
    <name>A0A2X0N5K4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C020g09101</name>
        <name evidence="11" type="ORF">BQ5605_C020G09101</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="FQNC01000082">
        <property type="protein sequence ID" value="SGZ17181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N5K4"/>
    <dbReference type="STRING" id="796604.A0A2X0N5K4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF66">
        <property type="entry name" value="HISKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="294"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="10">
        <location>
            <begin position="807"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="609"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="658"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="966"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="613"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="658"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="977"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="895"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGZ17181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="988" mass="108655" checksum="6C4E232008BBA08E" modified="2018-09-12" version="1">MQSEGSSMHHLTTNENMGIFSAVWSFVRWRIWGMIWYVQHRRGERGLSLSYPGLTIVLAWSCFSRFFFPAYVDAKVEDGFQKEQWWSAKSVHIFGSCFLVFSWVLATAILQRPWSLWNKISFYGIQPLFTIPLAPMAALDVPRRRPWLWQTVAFCALWIYATNNVIDMYTCGFYTTRARCGKKDFLGTMYYPSCQIVIGLFALGQKRLYALIGALSWVVVVGATLLPHRVTFIRNVVNLLLFQGFVLYLHYMRELSDRRMYTLRAELKIQYQGKARAQQNERKQMDARRRFSSYIFHEVRVPLNTASLVVQQWKALGLIDPNSEAAVEFQALDSSLTAMSQVLNDTLDFTRMERGGFTSVSRPFSLHDVMNSIFGPLKLDAHARGLAFETALDLRIDDVAKRAMYPDGANVEPIAEGDGWMMGDEMRLRQVINNLASNACKFTPAGGTITIVTRLVFPDPECGSPDWRKHSTSTDTTAVDGDECKATTLSSNRLEQHNVATSPSDPPQKRVLVARIEVRDTGVGIKTRAMTGDRSLFSAFVQTEIGRQQAGKGTGLGLSLVRQIVMLSGGRLGVKSKVGEGSTFWVEMPFGVGPQAREVDDGFHMVGMHLEKSSSSPSPPSNSAHSSDLRFTSSLAYRPGEPGLGSIGEKDGIEMKQTSYTFSPPSSMTQPKTFIPLGRDSAENTPPATPLPPSTGRLDNSQPMSISTSFAREKSASISSALTPAEGELHRPAGPSHLLSSASAPATMFSSGPSTPTMYASTSMNSSTVTRTVSPVATPSGTVMVGTMPSAAARKSAALEFADGALRVLVVDDDMLTRKLMSRMLERLGCLVSTAENGAVALDMLLGPENSSPPESGTIGSSFSMKNISSLPIMPTDVNPPILSMPPSYGITFLDNQMPVTSGLQVVQKMRLLGRTDLIIGVTANALRTDQEEYLEQGASFVLTKPVLEADLRRFLMLADRRRAEAKSSVAQLQRRSTSESRPKLPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NAM4</accession>
    <name>A0A2X0NAM4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C031g10969 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C031g10969</name>
        <name evidence="1" type="ORF">BQ5605_C031G10969</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000068">
        <property type="protein sequence ID" value="SGZ06774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NAM4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ06774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="147" mass="17214" checksum="9A7FC2CD05518B0D" modified="2018-09-12" version="1">MHLFRRFRLNSRKFRMRLFDLVLQLRNRLFELSTASKFATKLRLDLSERACRRGKSVQCLGETLIGRTNSRGKLGHVTVRGFDRFPQAGDGGSRALLHLHRRSSQFGQLALKRSRQRRGIDRGLLGNPEFILRLRKLILEFRELVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NB48</accession>
    <name>A0A2X0NB48_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C100g13129 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C100g13129</name>
        <name evidence="2" type="ORF">BQ5605_C100G13129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000075">
        <property type="protein sequence ID" value="SGZ11040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NB48"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ11040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="174" mass="19813" checksum="4BD3209DC9275C6F" modified="2018-09-12" version="1">MRDDFKVFTIEPRSSTKRNASGEVTGRKARLVAQGNRQRDGIDFSEMFAPVARFSSIRCLLALAATNTFHQADIDKAYLHGELDHDIWMTTPRGFDFPSDQVLRLRRSIYGLKQAGYKATGTDHCIYSRIDDQQRPHYIALYVDDLLIVSPGLDEIKCVISGLEQRYGIKRNLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NI52</accession>
    <name>A0A2X0NI52_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C042g12017 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C042g12017</name>
        <name evidence="4" type="ORF">BQ5605_C042G12017</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000116">
        <property type="protein sequence ID" value="SGZ31839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NI52"/>
    <dbReference type="STRING" id="796604.A0A2X0NI52"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF39">
        <property type="entry name" value="AMINOTRANSFERASE CLASS I_CLASSII DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="3">
        <location>
            <begin position="78"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ31839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="466" mass="51322" checksum="D05BE9E9E5CEBD67" modified="2018-09-12" version="1">MPSTVVPQLSKRGVNALHRPPLLRCALFDCQYTSSDTSGLINMGVAENSLLTDWLLEYFHSNFKLEYSDFTYGTALGGSIRLFKALNHLFDKYFHARVPVSREHIVAGTGCGTVIDLLVSCLADDGDGILVALPHYSGFVSSFGCRNQVVAIGVELEQGQEADASSLERFEAEFVESEKNGVPIKAVMLCNPQNPLGFCYSRETILAYCRFAEKHNIHLIVDEIYALSTFSTPEYPDAVPFTSILAIDTLGEAGCSPARVHAVYGASKDWGANGLRIGALISQANPELHIAMESSCLLMKISSPADALWSSLLLDPVALPKYIEMNQSKLAEHYQVAVDWLKRHEIPFRPSNAAHFIWIDLRKWLPTQTSDGQAIEPGMAQEAELAARFAEQGVVLARGAAYGHSVAGYFRLTFCLRPEVSAIGRGRVERALGLQLTQREVKVKVSKEDMRALKEVEDALHDLDTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NKS3</accession>
    <name>A0A2X0NKS3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C011g06244 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C011g06244</name>
        <name evidence="2" type="ORF">BQ5605_C011G06244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY11710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NKS3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY11710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="188" mass="21696" checksum="E7FF29F60CF96B65" modified="2018-09-12" version="1">MVQPSSTVDRASRRRVIRQHLGAWLDKRHSLLPTWRTSTVHSSWTEQLVLSNVKLRLEQLQILCQTHNLQGYSIRRSRARELFLRILLSSRTESCPACESGYIFKRSTANDILVPRRHCVPCHTVYRHKTLESCQAELSNEICEREERSLTENTTQNRRRAATNNDTAAALTTTHGSVRADLHLRNNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NL35</accession>
    <name>A0A2X0NL35_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C011g06364 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C011g06364</name>
        <name evidence="4" type="ORF">BQ5605_C011G06364</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NL35"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35317">
        <property type="entry name" value="OS04G0629600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35317:SF23">
        <property type="entry name" value="OS04G0629600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="3">
        <location>
            <begin position="324"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="GAG-pre-integrase" evidence="2">
        <location>
            <begin position="432"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY12028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="590" mass="65834" checksum="A69F3D46F1F3C134" modified="2018-09-12" version="1">MSPSETIAQESGEIKIAKLGKDNYELWSIRVEAYLESKGYASVLEHGHVRPSDVSLAEWRTMHGLDASVTDTQVVVNLQKKDRSARALIIQCIDDANLKMVKSKTLSAKDIWDKLRQHHEGNAKPFKIRTLLMELSNAKYDEDENMGEFLKSMIDKADQLDDLGQKFGDEAMIAYILQALPPSYEMLKQAIRLGENRSVDHVINRLTDEYTERKLSGKFDKLLKNAGALAVQSTQASRDPNCVCRGCKGKGHFAMDPECPKYDAKKNHGRARNRNKKKKQDSKESADSNELAEFVLTVKSLDESHSLQDNVANRVSQVNQGEIWILDTGASQHYVGDASLLSNRQSGNLKVQTASGQVVHCDMYGMVRFKLKSGASLSLANVYHLPGAPVNLISTRALFKSGAKCGWEDGKDVMTITYQGVILAKTLSGTGYALDFTRIVEDQAHVATRATVGAPLMEWHRRYGHVPVSSIMELVKSGAVEGLVLTDEKVHDCEPCISSKSRASKFSELATQVTDVLQRVFMDIGFVAEDQVDFQGRKAYLAIVDQYSTAKWMFPLKTKSAEEVTRVWIAFRQGVEKMTGRKIKRSRYPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NSW6</accession>
    <name>A0A2X0NSW6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">2-(3-amino-3-carboxypropyl)histidine synthase subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C010g05915</name>
        <name evidence="12" type="ORF">BQ5605_C010G05915</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the DPH1/DPH2 family. DPH2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NSW6"/>
    <dbReference type="STRING" id="796604.A0A2X0NSW6"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000002">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010014">
        <property type="entry name" value="DHP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00272">
        <property type="entry name" value="DPH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF2">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01121">
        <property type="entry name" value="Diphthamide_biosynthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00408">
        <property type="entry name" value="Diphthamide_biosynthesis_famil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="249"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="266"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY13620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="611" mass="67100" checksum="9C08CD981BF5CF4A" modified="2018-09-12" version="1">MSEHQSAPPPVANSGEDAITHTIDVEPEQFASEFESLSDAYEVENTVHQIVDGGYQRVSSSSHSASVVQAKCIFHPQIALQFPDELLHDSVQIYHLLRARLDAHIELYVLADTTYGRQVHACCVDEVAAQHVDADLIVHYGHTCLSPTLRLPVIYVLTKRPVDPSHAANSLASTSKESLDQDRKAIVLMYDVAYAYKARAYPKTAWCPGDHAQSYVGLTIFFRLKDLIFDQLEPRVNLPLSMARIDRRTNKINKKGKSPVHSDNEAASASAPTLATPQEEPVENDGDDTTPPDGVSNIAPAPTPEGLVPSETMPTRPTPPRIAYELPEGTTIDDCAIFYIGGESLALNNILITHGKCPVWSYDPRTREARLESSKTNRMLMRRYATVEKAKDADVIGILIGTLGVASYLPLIKHLRELIASHQKKSYTVAVGKLNPAKLANFMEVECFVLVACPENTLIDSKEFLRPIVTPFELELALTSKPWTGKYVLDFETLLAASDFGQDFVDPTKDEEDEEGPVFSSTTGKYRHPKRYATKGVTNADDLTAQASALSIRNTSSAVAQVLGSAAGDFLSNRTYRGLEPRYGMDAPAVIEQGREGGIARGYGYEKSVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NTY3</accession>
    <name>A0A2X0NTY3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C013g07147 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C013g07147</name>
        <name evidence="2" type="ORF">BQ5605_C013G07147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY14884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NTY3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="1">
        <location>
            <begin position="333"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY14884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="436" mass="48236" checksum="2B2EE18AA6130937" modified="2018-09-12" version="1">MAVCAHCKARHWECKGRTGHLSTCCSQGKVQLPPLSGPIPSIDSCLKGRIPNARSYNKLNALHSRTPHVSDFLTPLPSTGPTLGALIPAINQRPTFAKTWLICPAEATDTQLGPDGADSRIQRSTLTKLNSTVRTGNRFSGSCASAYHLAETDAPTTFLRRAPKWRCLSAIPTPTREIVDLKTLFSRCTVIDVPMVGPSTKSLARSIRLRCLSVTHYSSPQRKIASTSTFLFARSTKLGHSLPKDRDEEEGDAENGDGELSRSQLFAYDLHKRDEYFSIPHCPQRAFLAFVMTDTPRSRPIDSTYLQLDQENLRLTTGQGIISLTPDQVGCSPSLFITVTCHPEWPEIKAALGPNDQACNRPELIARAFEAKLNRLCDDDVFGNKQRAGCLADEWRTVSLLYFVVCLFDLCSNHVDCSVLLLFEFHPPVNLTGSHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NUQ6</accession>
    <name>A0A2X0NUQ6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C012g06690 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C012g06690</name>
        <name evidence="4" type="ORF">BQ5605_C012G06690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY15884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF463">
        <property type="entry name" value="REVERSE TRANSCRIPTASE TY1_COPIA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="755"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="959"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="993"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1018"/>
            <end position="1033"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY15884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1660" mass="183033" checksum="8195D2BC505CE4E4" modified="2018-09-12" version="1">MDVHRSDDNTLVTPTPAVGPGQPSDDDSPDEIDFLSRHHRAFIATDDDNPTLEAIEPVKSITSDPQTWREAMSSDEHDLWAQAASDEFTAMRDDFKVFTIEPRSSVPPGATIVTSKFVWKTKRNAQGDITGRKARLVAQGNRQRDGIDFSETFAPVARFSSIRCLLALAAANGYHVHQADIDKAYLHGELDHDIWMTTPRGFDFPSDQVLRLRRSIYGLKQAGRIWNRHIDTSLRSLGYTATGTDHCIYSRIDDQKQPHYIALYVDDLLIVSPALDEIERVISGLEQRYGVKRLGPAEYILGIQIRRLEDGSIALSQERYIMDVLARFHFDTTTRGATVPMTPGLSLTAVPGQGTERIRSWYLQAIGSLLYISLGTRPDIAFAVSYLSRFANNPGRRHWVAVKHVLRYLRATYRDELLYACGPTKITGVVGYSDANWGACVDTSISTMGFVFYLAGSAVSWSSKRQTRVADSTTDAEYLALSHAGKEAIYLTQLLSELHVRPVDAAHIFTDNEAAAAVVHDPVHTSGTRHIRLREHFVRDMVHQGDISLSHVGTANMVADIFTKALGPKIFGVHCYALGLWTRHPRLKSTSRSRGGGVVDRIELIEYIAEGTRLEEGLYLLDADHSKCQHLALLSRSQSSVPLLTLHRCLGHLAPSSIQKMVAAGLLEGLGAGYSDEEVEKFVCNACLSAKGHRLPFPDSDSHASERLGLVHSDVLSLPERSLTGKRYLVTFLDDYSRKLWAYAIGHKSEVFSVFKTWLAEVELETAFTEFCKARGTRRQYSIPRTPQQNGRAERVNRSIVEGILALLADAHLPKTFWEEAAAYFVYCKNLVQHSALDKATPNSVWQGGRTTASALHPFGCAAWLTVAPELRSKLDPKAVRVLFTGYDLASKAFRFYDTTTKKVTLGRNATFVDTEFPGLCGDSAEQDDDTHFASAPFADPHTTVKPWTPLVRSAHMDVSSPLDDSSMSAVDVAPGYTGGTLLNSTDAESPSSPSPAPSSSPSPEPASSPSPAPSPASSPSSAASSSPSVSPADSEYSADPLDVIGSQPQAPPDPLDAQPPDFSTYREPASAEESPDELDLIGHHSRDESPDEIDFLARHHRAFIATDDDNPEAEAIQPVKSITSDPQTWREAMSSDKREVWAKAATAEFNSMRDDFKVFTIDDRSTVPAGATVVTSKFVWKTKRNALGEITGHKARLVAQGNRQRDGIDFTDTFAPVAHFSSIRSLLALAATNGLHVHQADIDKAYLHGDLDHDIWMTAPRGFDLPGDKVLRLRRSIYGLKQAGRIWNRHIDASLCDLGYTATGTDHCVYSRLDDRQHPHYIALYVDDLLMISPDLAEIERVISGLEQRYGVKRLGPAEYILGIQIRRLDDGSVALSQERYIMDVLARFHFDTTTRGTTVPMTPGLSLTAVPGQATERIRSWYLQAIGSLLYISLGTRPDIAFAVSYLARFANNPGHRHWIAVKHILRYLRATYRDELVYTRGQARITGVVGYSDANWGACVDTSISTMGYVFYIAGSAVSWSSKRQSRVADSTTDAEYLALSHAGKEGIYLSQLLEELHVQPVAPAHIFTDNEAAAAVARDPVRVSGTRHIRLREHFVRDMVNRGDISLSHVGTSDMVANIFTKALGPKVFSTHCYALGLRTRHPRLGSASHSRGGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NWU1</accession>
    <name>A0A2X0NWU1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C012g06991 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C012g06991</name>
        <name evidence="6" type="ORF">BQ5605_C012G06991</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NWU1"/>
    <dbReference type="STRING" id="796604.A0A2X0NWU1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF3">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015919358" evidence="5">
        <location>
            <begin position="20"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="120"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="234"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY16793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="419" mass="45682" checksum="DDCD82BFE49D0E20" modified="2018-09-12" version="1">MHTALHWAAALARITIAKALVNFGADIFRGNNVGETALIRAVLVTNNCDQDTFPALLEVLGPSLRTIDKSGRTVMHHAALVAGVKGRASSARYYLESVLEYVARVEGGRFQDLVDAQDNHGDTALNIAARIGNRSLVRALIDVGADKRKANNLGLRPGDFGLDGVGLEATEGELAIESLRSTPSTNKNAGLSAPTRASNEVLQNLTTMIKSLEADFKAELGSKAEDFQATQTHLHSVTKELQAQRRELDQWQQKAAALDAQHARIRNLKRAIHEEDHFDWTGRTEIDGTPAIVAAGPSFTYRGPMSVQLPNSSNVEFDADPKLPAPGSERELIHLIRLQGWYERVLGLLDNRLSRLEGGEIELENELQRIVAKVCGVDVDKVDTMFETLFAALESDGSTMDQARIAGFLSKVKDGSFVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NX27</accession>
    <name>A0A2X0NX27_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C002g01744 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C002g01744</name>
        <name evidence="1" type="ORF">BQ5605_C002G01744</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY35257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NX27"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF1">
        <property type="entry name" value="HISTIDINE PHOSPHATASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY35257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="375" mass="42228" checksum="09DADF210C0AD0A5" modified="2018-09-12" version="1">MNGNTIDTRGGTSQYQSLGTTFTPTRYTTVQGFFKQADPKFNSKGYDLLDDSFGLIEQGPNRWHIFHAQIDKLNREADKQTTYKVVYLARHGQGYHNLAESKYGTAAWDAYWSRLETDGNITVGPISICLFYSCSMAADLHSGLLHLKWGPDPPLTPLGRQQAEDINTAWKRQVAEGVPLPERLYSSPFTRAADTLRNTWHDILLNKGLKPLILERLRETIGCHTCDKRSEKTIIRERFPTYDIEPGFSEHDQLWSADYQESPRQQALRIQQQLNQIFDTDPSTFISITAHSGVINAFFRVVEHPDVSILPGGFVPIVVRATRCVEHIRDKWLEVTIHCSDPGFITGSDSNERGQSFAGGQAVYAGPFDGKLPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NXW0</accession>
    <name>A0A2X0NXW0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g02046 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C003g02046</name>
        <name evidence="1" type="ORF">BQ5605_C003G02046</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY38552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NXW0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY38552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="167" mass="18342" checksum="4A6408F93D8C9FB2" modified="2018-09-12" version="1">MNYRALEQVCQRTRHFLQKHINTWAPRWSSLANAQATMNMGGNDVIVIQALLTDPSRGRDVSMLAAKPLLGRKPPVLGRLTEVEVDFSDPPTSTILPIVATASSNAGSSADLGTSSALTRAGTTKGARHYEMDPNDPQSRRFCRGLTRAEMNGRAWHQKKCHNFVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NYK5</accession>
    <name>A0A2X0NYK5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C014g07711 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C014g07711</name>
        <name evidence="1" type="ORF">BQ5605_C014G07711</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY19636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NYK5"/>
    <dbReference type="STRING" id="796604.A0A2X0NYK5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY19636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="142" mass="15694" checksum="CF8F687861511CE4" modified="2018-09-12" version="1">MGFPFRGSRAPGARASFFARGSQESVPCGIWQLPIYTVDFSSARAIDHAPRFGGFWLVPPFNVEKVDFSSARAIDRAPRFDGFWLVPPFRVEKVGFSSARAIDRALSIFIFTGNSGFYSKTYPGIGLYPTYDTYILSGVCGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NZ42</accession>
    <name>A0A2X0NZ42_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g02556 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C003g02556</name>
        <name evidence="1" type="ORF">BQ5605_C003G02556</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY41785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NZ42"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY41785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="419" mass="47244" checksum="2B5A06E8AB07E714" modified="2018-09-12" version="1">MQDVVDSVAARVWDVLLGGSDAIWQGLARAAIVRTPPAPDFDLATDAWPCDYTPIRTDLPPRWQAVLKVPSTHNAQVKPRTLTLANLLALPIRLHTLHYLPGAPAVSRPPYEADHAAFAIYAKVADLFRRELYPGGGFHLWTPPTDVVVSNSEYDQRGRPQREHIVAWYRHAINRLRFTPIAQPVAAVRINGPPRVRPRSEVRPTTPLEPINTIQLAQHGSYTIRRVRRVLNAKAFTDTIGFRDSLQPDDLKGFWKGVNSKALTAREREVWFKLVRNFTPTRSLQFHQKHDDSPACLVCGAPKDDREHYFFDCVDSGNVWIAARSVLCDALGLDTIDNTHYTAVQRMFGLPKLKASLRDQEGAGRTIEIFTGLVLEMIGSGRWGMQKWGTRIEGVVRRRIILEERLKLRAGGAWGRRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NZP9</accession>
    <name>A0A2X0NZP9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C019g09012 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C019g09012</name>
        <name evidence="3" type="ORF">BQ5605_C019G09012</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY24114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NZP9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34862">
        <property type="entry name" value="SPARK DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34862:SF1">
        <property type="entry name" value="SPARK DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016095299" evidence="2">
        <location>
            <begin position="25"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY24114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="305" mass="31431" checksum="60BD8DC3813AB67D" modified="2018-09-12" version="1">MLLLAQWNFLAAVSLAVGSTRAAAGPVDPMTALMNKLSEPCTASAVQLLGSDFAACSDAMDFMAVIEAQSNLAGSLTSWSTNICKINCSDKALSDARTIVTSGCSKDLQDPNSLPALILGAITNYPALRHGGCSYDKQHNTNCLANFVTTYEKYSGQSLTISLFLELGKNASSLSVIPAAELCVDCNKVLYTLGYNLLASSPLDQKALLTETTTVCSATFTDLKDPSNVTLVGEASAPISQPSTTTNVSCTPGSNPSSGCNPATSNPSAPGTTVAARNPSVGSRSSTVDGSILTVFALIGGFFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P099</accession>
    <name>A0A2X0P099_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C001g00511 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C001g00511</name>
        <name evidence="6" type="ORF">BQ5605_C001G00511</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IPP transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY47228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P099"/>
    <dbReference type="STRING" id="796604.A0A2X0P099"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088:SF89">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01715">
        <property type="entry name" value="IPPT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="512"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="518"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY47228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="541" mass="61477" checksum="8DE3861499BA46BA" modified="2018-09-12" version="1">MISRVARSGTLQLRSRASSVAPAQRVRQTVLRTMSTLPVQRPHVVAVVGTTGVGKTKLGVELAQAVASMALSSSSNSGAEVINSDSMQVYKGLDLITNKATVEEMQGIKHHLMAFLEPGQEYSINEFQADALRLIDDMRNRDTLPILVGGTTYYLQHLVFPNQLVSDTPAISVPRTTPTEPLPISATHHFPPKLVEHIHALPHELLQLFLALPCLPQTSTPDSFPPNFPLGLVPEPYRSPSDFAPALYDLLDRLDPRSAERWHWRDIRKVRRALEIVWEGRQWDDVKQEQNQKGRGQARFPTLIFWPYAEPELLSKRLDERVDRMLQLGLLEEIEQLWALAHRKGGEGSDETDYSKGVYQAIGYKEFSPYLASKNDSSIDSKSLFDAAVERMKISTRQYAKKQVKWIKSKLLPAIKELETHAVTIVLLDVTDLEKWEENVHKPAIEYLRAFLNDEPITDPALLSPVAQEHLSVSNTGSPARPKRACPICTDDPSRPFFVEYHLWDSHSRTKTHRRRLREVGTRGRRPPQREEREEREERTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P0E2</accession>
    <name>A0A2X0P0E2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C001g00571 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C001g00571</name>
        <name evidence="1" type="ORF">BQ5605_C001G00571</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY47769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P0E2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY47769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="61" mass="6978" checksum="853431B269D077E9" modified="2018-09-12" version="1">MGGPAWWNPQRGVLRWELFSSAAKSFLRSTISRVGVGIADKHRHFRARRRKVVGASVSAWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P145</accession>
    <name>A0A2X0P145_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01148 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01148</name>
        <name evidence="2" type="ORF">BQ5605_C002G01148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY30387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="603"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY30387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1464" mass="163791" checksum="D55C17F8EBFBEF31" modified="2018-09-12" version="1">MSSFLNGELTQRPRFLTRPSLRHFQSQGRLRREPCTSQDGAAPLAAPHRRPSYTYATYIPSGDNAPRVPPDAPAHHTAPPSPSPSLYFSPTLSVSPQLLDSTSANGAYRDQAADIDSQSDADKGVSYFSTLPPDSPLELDVDHFAPTSHDIYDGVADAPTANDAPTPPLSMPGSARLAPFDYHLQQRGQGHAAILRRNSDQPPLAPPTSMYDHRPRSSSTSNTSVIEVPTFVRPQYTREPVSATRPVLGEQRGRHVNLLSVDDSPATLKKRPSLVLTVDMDSPAPTAKTNGGFQFDATSQNLSSGTPTTNGARSTRRVYAADSTAPQPSPLLGDGSTTPLGSPALSFLPKLWSSNGSNADSLPSSIASPMGPAPPMERRPSTSPRLGALAEPIGRLASGLVRRASNANLRADELPMAQSRRGSTDSLPVTESPLPRLGPAIKVSSVVSLPLPRRASYASQAREKEEEKQKEIEHRDFRKRVKAAHNRAFSWAVRPGDIGFRLNDGAPRSRTMRGVPSANPVVRKVAIGFVIALTLWALFPLSAVRDRISHHNDRHHNRPATRARPDGKLFIHPEILRGPAPAPSKLTAPVRWIARVLHVTSSHTHYDGRDDSRNNERDHDHSHLQGHAPEAKKKHHSKFVAAPHVAYKHHKALPPPLQHSDDPQRDTLVLYRILGNDLPPRHSPGQTLRNVRFLLQYESDFSVLPPLGPHVDHHAHLYGSGSKAYARTEEGGLRVDKYFVLNRIADAQMVTAIISLLHMYSVPDSRILLIPFEWSEYERREFRWEGGVDKVRGWDIGASNDDHEAQEAHRLLMEEHALAHNVAFSSHEHFEHHREGRLKKDVLTKLRAIDFTYHEKNLYAMNNNGGRNFALEHGRSLPNARWILPLDGNSFLTPAAMYSIVQTLSIAGEGPQASRYLLMPMARLLSNDDVRENNTIKLVPEHHHHDRRLSAIEEAEHFSRPDTAPDTPEEPQIGFRYDSTEDFQEAMRYGRRSKLELLWRLGAIPYSKGLDQRTLPWESEDRHHVTADAWASIPGAPGVNASSPIHRPLEEWGHPDDAAHPMRYEAPPFVNAGWVYRLFSGYKRQEETNREAVTLRNTNRIKGIVAFLERLDEQIARGEEGCDPEENKAECGFHPDRFWNFNKSNLEMLRSLYEQGEEYSVKTVRDFEHQIQHAFNYVYKHLDTPEEEKMDAHTAAQHSLMFALAGYLTGDDKYTTVASQLIMHRFVNQLPHFYLEKDQLEQQLVYSGLEGEDETSFEHALAEHGSAYAFPPSPVDRGEVPKWSAQIGRRVSAHDIPRLPFDPLDFDPSMMLDAVRLLNHHDSPHDEGESLVSRNIVQPMLTAHLSWLLYSPDALQHSRRPPNAGSGAAYDAKIAVLAAFLDDAKLLGRVANRARLRLPEENREHGIMFVDEEVKAVHWRLIQGLSHVRFRPYSIIMDLDDLDHGGYDGSAHGYETPMDILNVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P184</accession>
    <name>A0A2X0P184_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g03787 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g03787</name>
        <name evidence="2" type="ORF">BQ5605_C006G03787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY53665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P184"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY53665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="55" mass="6047" checksum="A7AD41E3391B3A9E" modified="2018-09-12" version="1">MTGIRPHPRVVYQSLKGMAEALQAAGKDTTSDRGGPMRGQPNTKQIEAHVTSWQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P1B4</accession>
    <name>A0A2X0P1B4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g03837 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g03837</name>
        <name evidence="1" type="ORF">BQ5605_C006G03837</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY54083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P1B4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY54083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="70" mass="7732" checksum="3F1773E18468F897" modified="2018-09-12" version="1">MQTKHFDIAHLFVRERVASGEVELEYCPTHVNAADIMTKPLGFQRFDQLRALLGMVSLVSLTGGSVRSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P1D6</accession>
    <name>A0A2X0P1D6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01298 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01298</name>
        <name evidence="2" type="ORF">BQ5605_C002G01298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY31980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P1D6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY31980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="714" mass="78725" checksum="5B2CF9556FED63F9" modified="2018-09-12" version="1">MRTRIASSVRRDEGGAPPMFSASRTPRTAIALSDITNNLVDTKPDLSAGKKKVPAGAHQRAPSNKAKPSKAAAATASDAKPVKPVEPVELLKLGKPEKSSGVDAVAADDDSLHASTHSSDGDLHEAGHRLDALTTSDNEGEEDKSPLGSDSGGPETESDHLQQPLKKHTSQTSSNRQVNDTPDDLSDRSEDNLPLPSGRGKKAARISDLDVHLEDLSDDDSPIKGADQPLTPRPSGRATGSFRPREDDPAVILAALGIPATPHVVQIAQGLLEDPDMEERPGLLRYHITHSRMIEALLKEMTKLKEAVAKLSVTDLKICASFRKRQNRLFRKKETDYLAKTRTVGDSVRRRYGPRFLWAPRSFCAIGMQRRSSLHARSQEALLRFGTVTRGIWDSNLEFQTEALSIFSTALATARSDLHKLIGRVQRKEVDMLRAMQSWYKDNPTTYTDERLAWCGFATTLAKKAAQRFYHARYCPNGAFDCSIFLYRTVVSQFYDADTSPMTTRPKVSTMDSTCQTLCTTVITTCQPVADFQRLVLLYQQNCWIAYGDVSNTRIYMGLLREPPFDRRGTRPASSKLARLRSTTLLHEFARGLRARKPTWAPGGHPMGAMNFTQRCVGLKLNCGYFRMAGRATSVPPTAVNCSRVRSNRGQLRLRGFSVGARRQAAAGQKPTGHGPLFLVQNHVVLLGLGAGTGFRTAWKERHKMKGLSKYCTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P323</accession>
    <name>A0A2X0P323_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g01931 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g01931</name>
        <name evidence="2" type="ORF">BQ5605_C003G01931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY37975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P323"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY37975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="60" mass="6211" checksum="5C0F43CD91591F69" modified="2018-09-12" version="1">MGCARDIGGDNKGGGSAIVFGGRAIRSTKPPWNRDGGEGARPEAFARGTMEGDRTFGLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P3Z5</accession>
    <name>A0A2X0P3Z5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DnaJ homolog 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C004g02641</name>
        <name evidence="11" type="ORF">BQ5605_C004G02641</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY66202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P3Z5"/>
    <dbReference type="STRING" id="796604.A0A2X0P3Z5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000005">
        <property type="entry name" value="Chaperone protein dnaJ 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096:SF52">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="9">
        <location>
            <begin position="104"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="10">
        <location>
            <begin position="254"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="7">
        <location>
            <begin position="254"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="474"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="477"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="548"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="558"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="597"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="619"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY66202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="648" mass="67882" checksum="28CD6B062A8EF0AE" modified="2018-09-12" version="1">MAPLARTPSLLSLLNGSGISPCVCRTVSSAVTASPVASGSRDGPSQRSFAVASKAPSSTRRLSTAAAPRQRLGWNLVSSALSRRAGNKVHQRTFHASSTSLVQDPYKAIGVAKDASASEIKRAYYQLAKKFHPDTNKDKGAKERFVEIQEAYDILSDEKKRADFDRFGPASTQQGFDSDAYARASSSFGGAGFSDFFGGGATGGAGGAGPDIFESLFGAFGGGRGGSARPGQGMQPGEDIEIGITLPFLEAAKGTSKTVTISPVVDCGTCKGSGLKEGAQKSSCRACGGSGTRTFTIQSGFQMASTCNVCGGSGSTTPYGSGCGTCNGVGKVRERKSVEVRIPPGVDDGMKIRIDGQGDAPLGGKGRVGDLYVRVSVLPSKTFQRQGSNLYQDVGVPFYTAILGGRARVATLDREVEVKVPQGTQPGEEMVLRGRGVKKLYKDEYGDLVVRFGVQMPRTLTPAQRRILQMYVSETESPGSSSYSPSSAPPSSNDGGSTESQAASAQSTSSKKASKLPDENSPGFTHQAKPPPSDAVSGKWWSTMDENDPSKPLDEAAAKPSTSTTSPPQATSHKPTPETADTKGKEDGESLLGDLWNGKDKVKEALGCDESEASTATTPKEKNSTKSKKKNTDKDEPVVRETGKEPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P936</accession>
    <name>A0A2X0P936_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g04301 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g04301</name>
        <name evidence="1" type="ORF">BQ5605_C006G04301</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY57740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P936"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY57740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="118" mass="13456" checksum="7D5C971646322F84" modified="2018-09-12" version="1">MIVLLLNSIKEKNRGKRCTVPECARRGEQWYTIPLPSSPRAKKQKSCLIARARTSFFGWLNGPADLGRRTLTERSLQMHKVADVSGWSESRRPIISRTMYPSQDVYFCSSVIIPQNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P9H5</accession>
    <name>A0A2X0P9H5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C007g04462 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C007g04462</name>
        <name evidence="2" type="ORF">BQ5605_C007G04462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY60654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P9H5"/>
    <dbReference type="STRING" id="796604.A0A2X0P9H5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="674"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="806"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="996"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="595"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="674"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="813"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="870"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="996"/>
            <end position="1013"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY60654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1028" mass="111098" checksum="D535E7E27BB54B63" modified="2018-09-12" version="1">MTNPSQATFRTHLTSLSFHTHLRRLSSSSSQSSPTRSDAKSVAAAKVPSTSSPSTVPKATNGKMDPKTPHILSFSNRISLSVRTPSYHFKSYGLFSVVVMPLSPLPPKNTSNTSTSANVRSPSAVTTATATTPDHSSTCRRKKGPVTPEAGIGAPSTNFDILRADVWIGAFGRWFAWKWDAPTGITPAEVTEDDERRERVSRSVIKITTEDAPSKRSSKVPKPLTLSTNSAPTSSTSDDPANSTEPPTSPMTRVGRSSRPAKRPLRGMQRRTSPNSLARLRSQVESNAAAAAAAASAAQGSDKTSKISKDEVKKVAVGSTVTKDEEDLRVNKDGPAPQKDKTTTTPDQPNTTPTGRTSGSSEDRVVQELQLQVEELRASTDDAERRLQEELEVLRGRKRDEDLSRQELKQRTKVLEEQKRIAELHRTETERELNERKSVVRAAQDRVDKMRNEILEIDKKEVELAERREKKKRDRKERERKLKEDVEKRKEELKKVEEGVNELADQVAGLERRLDARHEVLQVRRHEIVARNMGLGRNGPAQTYTYAQPSGVMSRWRGGGAVGYPYGGMYVYSNNNSRPGSVRSGHYDHYHSNYQSAPSSPVQSSPITPFDDSALGGSRPPGMSSNLGPDAHRSPTTQGFLEHRLQHRRHDLTSGEGNLSSAFLPFDFDTLDAPASSRSRPASINSPHDDANKGRPALALPMQYLDSGLLAGGDSSSINGPLSPMTPHQTSLIPSTLFHMLDEDDEDEGQFVMPDSPSLTAANGDAWKGLDLDLANDLTIGRPNRARDASVTRTADSDLGVDLLRHDSKSSGVKSPFSDGPSSSVVGSRSAVSSPPLVPASTSATTTPAAPSSFAPWDTPAEGVHVNRPSSREQQDDLPRAGLSLNPDAKAFAFSPRATSATIPTSSSTNLLPTLVKGRSASNPPLPTGIVALHRSSSGNGPSSLTVVDPFSPSFNSVIAPPPKSRMDFGHRLSPSGHSSLGSRFAFDAWASSPLTASPEATTQPSALKSNFNPFADDGDDLLGPLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PD55</accession>
    <name>A0A2X0PD55_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C005g03678 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C005g03678</name>
        <name evidence="1" type="ORF">BQ5605_C005G03678</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PD55"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY77594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="80" mass="9020" checksum="959FA757D4236235" modified="2018-09-12" version="1">MPRVQTQGMHAAFIPEIDAIVEIAPLLRVRNCTGRPVLDGKSRPEGSADDGKYRLHLHVPEWSTKLVSRYRKNNITLAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PD89</accession>
    <name>A0A2X0PD89_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C005g03527 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C005g03527</name>
        <name evidence="5" type="ORF">BQ5605_C005G03527</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY76889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PD89"/>
    <dbReference type="STRING" id="796604.A0A2X0PD89"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12363">
        <property type="entry name" value="RRM_TRA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="82"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="159"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY76889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="293" mass="32021" checksum="385B377E1C66CAB3" modified="2018-09-12" version="1">MSNHAGDSYAQEDAPMRAISGHYDDQEPPRPRSRSRSPLPPRSRDGASARPRSRSRSPPPPRRYEPPPPRRPAHAPVAEPSNVLGVFGLSIRTTERDLEDEFSRSGKVEKVVIVYDARSDRSRGFGFVTMADIDGADRAISDLNGMDLHGRRIRVDFSATKRPHDPTPGQYRGIKRDEDDFPPRRSGGGGGGYDDRWGSLRGTTIPDATTATIATRRVGTTVIAMTDRPDEGTTVAEGIVRGRGRPLGGVVTRAALVLLVVNVRFLLPASTERFFDASSPPALPFTFELSLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PDT5</accession>
    <name>A0A2X0PDT5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aspartate aminotransferase</fullName>
            <ecNumber evidence="8">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C008g04908</name>
        <name evidence="10" type="ORF">BQ5605_C008G04908</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="8"/>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY78653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PDT5"/>
    <dbReference type="STRING" id="796604.A0A2X0PDT5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006533">
        <property type="term" value="P:L-aspartate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000026">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF22">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="9">
        <location>
            <begin position="57"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY78653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="429" mass="47355" checksum="8D460D5E5E3028C1" modified="2018-09-12" version="1">MSLTRSLLTARSVRLSGASAATAGAVRYSSVWSAVKQGPPDAILGVTEAWKADKDPKKINLGVGAYRDGEGKPYVLPSVREADERILAQKYDKEYLPITGFPDFTKHAALLAYGKDSAPLKEGRIAITQSISGTGALRIAGAFLARHYPYAKEIYVPAPTWGNHIPVMKDSGLEVKYYSYYDKKTVGLDFEGLKKDMQNAPNKSIFLLHACAHNPTGIDPTKEQWKEISNIMKEKEHFPLFDSAYQGFATGSVDTDAFALRHFVSEGHSPALCQSFAKNMGLYGERVGAFSIVCSSAEEKARVDSQIKILVRPMYSNPPVHGARIAGTILSDPKLYHQWLGEVKGMADRIITMRSQLYDLLQELGSKKEWGHIKSQIGMFCYTGLTPEQVEKLSKEHHIYLTKDGRISVAGVTPHNVRHLAESIHAVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PEG9</accession>
    <name>A0A2X0PEG9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C022g09452 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C022g09452</name>
        <name evidence="2" type="ORF">BQ5605_C022G09452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PEG9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ22205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="138" mass="14557" checksum="77356F822A91DF2A" modified="2018-09-12" version="1">MTFWRPDTNTVFVSDDANFDESSFEIQRGESDEAALREDAPTTIFGDAPGGDGRDATPPPVGRAMSPDREHTSAAPGRERASGNGGRVQHSNGQELTPIVPNGRAPASVAGDGRAPPPVASRRPSSFLDDDADNKQPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PEK2</accession>
    <name>A0A2X0PEK2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C022g09492 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C022g09492</name>
        <name evidence="2" type="ORF">BQ5605_C022G09492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PEK2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ22476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="131" mass="14300" checksum="AB74686589DFDAEE" modified="2018-09-12" version="1">MAAQDYYGGQQNKGYPQQGGCTFVVVVVFLKEGAGRDPPRRTNKDRLNRATTPLKPLNPLSTMLITVLYPFESNRAYYPQQGYGQQQMPQQVYVQPNQKSPGVGAGTGCCACLAGACLCCCAEEMCCDMLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PHZ6</accession>
    <name>A0A2X0PHZ6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C046g12245 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C046g12245</name>
        <name evidence="5" type="ORF">BQ5605_C046G12245</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000112">
        <property type="protein sequence ID" value="SGZ30853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="490"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="743"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="798"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="835"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGZ30853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1416" mass="154514" checksum="5392F986BCE9FC41" modified="2018-09-12" version="1">MSDAGASAPEAKLREPTPDAPPLRPPTHSAAFATTELLCNSSGYRDWVLAIRSRLPSGVVRYLNTGVPLESWPASYVPLWDHYACSSICASVDSQTVLPGLSPYLDESLAAPKVWQALRERYGTVSAVDLLPVIQRLFSSDPVPVTPDLFLQFRDSFENDARLLQDSQVTVNALLASHLLARLPSSFDAWRTTFVADQGDSTAMPSATEIFTRLYRDVKARPVDTPVAAVATPQARHGCSRPCPNPSCRKLHWLRECPDTAWAAAYRARRTAEKKASQPVASPAAVDTPNSVSFTACLLTTPSPFRKSAWLLDSGANRHMTNDRGLFSELRTVAGPRVGGVAGSLPSTGCGTICIQTSTGPITVSNVLLVPDLPCNLLSVFQLDQLGYRVSFASRCASIARPSGAVVATAQAIGNNLYALALGPTPCTPKALLAIPTKVSLLTLHRRLAHLPVAQIKNIVQKGLVTGVDWVYKDQELRDFYCNACLASKAHALPFARSKSIASGRLDLLHVDVAQMPRPTFGGHWYMLVIIDDFSRKHWCLLLALKSDVFPRLRDWILEVENATGNKVKTIHSDNGGEFTLRNFVNFCASKGIRRELTIPYTPQQNGRVERSNCTVKEGILALLYSSGIPDTRWHGFAPDISTLRAFGCRAWHHLPSAKRTDLDPKAVPLLFVGFDHHAKAFRLFEPSTRRIQLSRNVVFRESEFPALRPATDVRAEPIPLPVTVDAYPDQVDPLESSLVASPRSLAPRAEPPRPVPAAPDQGPHRPAPAREVPDQDSLAPPAPDQGSPARELPDPESPASSASDQGSSDSAISTPCPSPRPVASRALPAPPSPARSDSPDPIDLLPRPRDVASLCQAQEFPDDMDDALHSPSAVAYLASGAAALIETSPADPAELIAPARDPPHWRAAMATPQADEWRLAARDEFDSLLRDFSAFTPIDESLVPADAKVLGSRFVFRTKRDQHGQVKSYKGCLVARGDSQRSGIDFDETFAPVAKFTSIRALLALAAAHGYHVHQADIDKAYLHGKLDAPLYIRVPDGIYMPGKVLQLHWSLYGLRPAGRIWNDEIDSALSALGYVATESDHCVYVRTTGDVHHYIALYVDNLLMISPSLPEIERTLQGLEQRYGVKRLGEAEYVLGIQIRRSPDGSISLSQEQYLKDVLARFGMSDAHPVATPMQPDLRLEVELQPTPFPDRTRYLQAIGSLMYASTGTRPDLAYTVGYLARFSHSPSAAAWGAVKHAFRYLAGTLSHGLRYARGNPAPLLGYSDCNWGACVLSSKSTMGYTFVYAGAAVSWSSRLQSRVADSTCDAEYLALSHAGKEAIFLSQLFGELGLSSSKPVLIYGDNQGANALTKNPVFHARTWHIRLREHFVRDMVSMGDIVVQYINTGEMTADIFTKALSRDLFARHRGRLGICAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PI43</accession>
    <name>A0A2X0PI43_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">BQ5605_C030g10745 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">BQ5605_C030g10745</name>
        <name evidence="18" type="ORF">BQ5605_C030G10745</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000069">
        <property type="protein sequence ID" value="SGZ07855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="17">
        <location>
            <begin position="405"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="688"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="741"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="778"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="SGZ07855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1359" mass="149671" checksum="42F789AADE731170" modified="2018-09-12" version="1">MAPLWFLSCSSNFLVWSPLVLRSETYHRLSRLLAQPSYQCGHLRARPSLYFFTLRNMSDAGASAPEAKLREPTPDAPPLRPPTHSAAFATTELLRNSSGYRDWVLAIRSRLPSGVVRYLNTGVPLESWPASYVPLWDHYACSSICASVDSQTVLPGLSPYLDESLAAPKVWQALRERYGTVSAVDLLPVIQRLFSSDPVPVTPDLFLQFRDSFENDARLLQDSQVTVNALLASHLLARLPSSFDAWRTTFVADQGDSTAMPSATEIFTRLYRDVKACPVDTPVAAVATPQARHGCSRPCPNPSCRKLHWLRECPDTAWAAAYRARRTAEKKASQPVASPTPCTPKALLAVPANVSLLTLHHRLAHLPVAQIKNIVQKGLVTGVDWVYKDQELRDFYCNACLASKAHALPFARSKSIASGRLDLLHVDVAQMPRPTFGGHRYMLVIIDDFSRKHWCILLALKSDVFPRLRDWILEVENATGNKVKTIRSDNGGEFTLRNFVDFCASKGIRRELTIPYTPQQNGCVERSNRTIKEGILALLYSSGADSRLWGEAALYYVHCKNLMPHAGIGGEIPDTRWHGFAPDISTLRAFGCRAWHHLPSAKRTDLDPKAVPLLFVGFDQHAKAFRLFEPSTRRIQLSRNVVFRESEFPALRPATDVRAEPIPLPVPVDAYPDQVDPLEPSLVASPRSLAPRAEPPQPVPAAPDQGPHRPARAREVPDQDSLAPPAPDQGSPARELPDPESPASSASDQGSSDSAISTPCPSPRPVASRALPAPPSPARSDSPDPIDLLPRPRDVASLCQAQGFPDDVDDALHSPSAVAYLASGAAALIETSPADPAELIAPARDPPHWRAAMATPQADEWRLAARDEFDSLLRDFSAFTPIDESLVPADAKVLGSRFVFRTKRDQHGQVKSYKGRLVARGDSQRSGIDFDETFAPVAKFTSIRALLALAAAHGYHVHQADIDKAYLHGKLDAPLYIRVPDGIYMPGKVLQLHRSLYGLRQAGRIWNDEIDSALSALGYVATESDHCVYVRTTGDVHHYVALYVDDLLMISPSLPEIERTLQGLEQRYGVKRLGEAEYVLGIQIRRSPDGSISLSQEQYLKDVLARFGMSDAHPVATPMQPDLRLEVELQPTPFPDRTRYLQAIGSLMYASTGTRPDLAYTVGYLARFSHSPSAAAWGAVKHAFRYLAGTLSHGLRYARGNPAPLLGYSDCNWGACVLSSKSTMGYTFVYACAAVSWSSRLQSRVADSTCDAEYLALSHAGKEAIFLRQLFGELGLSSSKPVLIYGDNQGANALTKNPVFHARTRHIRLREHFVRDMVSMGDIVVQYINTGEMTADIFTKALSRDLFARHRGRLGICAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PIG0</accession>
    <name>A0A2X0PIG0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C043g12062 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">BQ5605_C045g12187 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">BQ5605_C131g13373 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C045g12187</name>
        <name evidence="4" type="synonym">BQ5605_C043g12062</name>
        <name evidence="2" type="synonym">BQ5605_C131g13373</name>
        <name evidence="4" type="ORF">BQ5605_C043G12062</name>
        <name evidence="3" type="ORF">BQ5605_C045G12187</name>
        <name evidence="2" type="ORF">BQ5605_C131G13373</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000059">
        <property type="protein sequence ID" value="SGY89318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000115">
        <property type="protein sequence ID" value="SGZ31503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000117">
        <property type="protein sequence ID" value="SGZ32056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PIG0"/>
    <dbReference type="STRING" id="796604.A0A2X0PIG0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052519">
        <property type="entry name" value="Euk-type_GlcNAc_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43190">
        <property type="entry name" value="N-ACETYL-D-GLUCOSAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43190:SF3">
        <property type="entry name" value="N-ACETYL-D-GLUCOSAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY89318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ31503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ32056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="172" mass="17935" checksum="6317DE95852CE5A1" modified="2018-09-12" version="1">MLGSLNQPTPSNSSTQPHPHPQSHPAPLNRYPPLFLAVDGGGSGVRAVIASHAGVELARASAGPCNVKSVTAPVAVTRILQAVNAALTLVPLSGDETCPGPQGRTPDAVPSLTSDTDQEQSSLMGHCFAKAWVGVAGVDSRTQGSDFEDLLRQALRMPTTDLILTNGEYTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PJZ1</accession>
    <name>A0A2X0PJZ1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C021g09316 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C021g09316</name>
        <name evidence="5" type="ORF">BQ5605_C021G09316</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000083">
        <property type="protein sequence ID" value="SGZ20959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PJZ1"/>
    <dbReference type="STRING" id="796604.A0A2X0PJZ1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF5">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGZ20959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="542" mass="60883" checksum="FE3F90CB02247A02" modified="2018-09-12" version="1">MSSAPNTLPQVSARDTKSHYGAIILGAGLSGLAANIQLKRKLGFTDVFCYEKSADIGGTWNHNRYPGAACDIPLSLYSFSFAAPEDVWMQWAAQPQILEYLHSVQKKFEVNNIAFYHMVLEARHSRQTGLWTIQVKDLKTGETKTRTCNILISALGGLSNPNDPSFDVRDFNGDVFHSAQWNFDVSLKNKDVVMVGNGCSAAQIVPEIADEVKSLTQIARSRQSIIRRPLAPDNTLVHWAKKYIPGFAWVLRTIIFLIMERMFRVSDVKRGAKDRDSLLKDTKKYIREVAPEKYWDALERASFAPTADFDIAAKRRVFDSGYYAALNNPKVDLVQDDALESVKGDTVTTKNGRKFKADVIVLCTGFKVHDYLFPVKIYNSEGVSLQDRLRDNKVSVYQGTCVADYPNLFWLMGPNTATGHSSVIFTSEAQITIAIETESPAFRAVTTCSMMRKLIKPILSQLKSSTNGEPAPTVEVTPAAQEQYNKKIRNEMKKKVWEKDGGVSWYVNKDTGLCTALYPFSQIHFWWNASFPKRADFKYIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PLC9</accession>
    <name>A0A2X0PLC9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C024g09881 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C024g09881</name>
        <name evidence="1" type="ORF">BQ5605_C024G09881</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ26301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PLC9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ26301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="122" mass="13462" checksum="73CB60DD06284330" modified="2018-09-12" version="1">MVTRVPALSCRSHPGPAREHYTRATLYRFARVLSVASPPSVLCPQPEFIALVSTRHPPFLKTFKDAMASPEAESWYAASVKELNSMGLHKVFKLSSPPTGARALGYRCVFTRKEDAEGNIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PN03</accession>
    <name>A0A2X0PN03_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C026g10212 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C026g10212</name>
        <name evidence="2" type="ORF">BQ5605_C026G10212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ27880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PN03"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ27880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="265" mass="29382" checksum="4BF5D297C9DC252A" modified="2018-09-12" version="1">MGSTWEEVRSDRLVWAAIVGGQKLWRHAPLQAKPLPFELVNSLLDCALANPLLDYDLLCFLAMLALGFSACARSGKLTLPDTIRFRDTEKLPDRDSVVISKSGFRRSGAKLFLLSTGSPLTRTWFVMRLHAEFGRAYSGHSLRSGGATHYALRGFLPAEIQRIGHWKSAAWEEYICISPELNMALLAHRNFGELNCICTACGENGHWSIDMKCPQHKRHSEWKSKSGSSAVNANAVTEMSTNHTIYSIGESSGAAPLRNTYVNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PN76</accession>
    <name>A0A2X0PN76_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C027g10303 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C027g10303</name>
        <name evidence="9" type="ORF">BQ5605_C027G10303</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MEF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PN76"/>
    <dbReference type="STRING" id="796604.A0A2X0PN76"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00265">
        <property type="entry name" value="MADS_MEF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033896">
        <property type="entry name" value="MEF2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945">
        <property type="entry name" value="MADS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945:SF534">
        <property type="entry name" value="MYOCYTE-SPECIFIC ENHANCER FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="8">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="106"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="234"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="298"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="361"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="361"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="426"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="508"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="543"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="581"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="605"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="630"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGZ28288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="655" mass="68499" checksum="D9961DCE99E784F2" modified="2018-09-12" version="1">MGRRKISIAPIQDDRNRSVTFLKRKNGLFKKAYELGVLCNADVAVIVFNGANKLFEFHSGDIDQTLLRYAHYSGPAHEKRGPEYYGATHPGGLVTSALGDKIAHRNAGEPGAEEDEVDEEEEEVSLVDEDEDADARGAQIKQSAPGGSKIKRGGNEDGKGPKVERDDNQRSDPRSDTLEEEQPSFYNDREHASQQQQRFQSGQDPPSPQSLAASGNWPFHLGFPQPVFNNPYTSFPGFPQAPHPSFAGQSYPGGPPNSNGGWNSQMPSHPGGGPGQGGNPMGQNPFWAMQNLVQTYGASMSGGMPGGGPPGPLGHTNGNSSNGGPGGPPNGFSGDFAALQAAYGMGMMNNPGAGGPLPPFFGASPANGGGSSSALPSLALSSLGNPNGPPGGPPSSSGSTSSAPFPLYPGSARQAPSEVSPVPIHRSTSVTSLRRASPGPASTRTTELSRGQSFDGVSQGRGPPSRSNSLPKPHLNLNIPRLPGSTTSTPGIDSNPRGRALLIHEGQPSNSEPESIPPIQGSQLLSSLGDSSSSHHMLPSPSTFFASTDFNPSNPLDGSYDRNEDEDQSRDRNAGSSHSPNEAEAHEDDAPRSLNWSAAPKLSNDRTTSTLNSSEGNVSTTGNSAATSSKRTESESGHRLGVDMEGDGKKRVRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PQK8</accession>
    <name>A0A2X0PQK8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C069g12855 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C069g12855</name>
        <name evidence="2" type="ORF">BQ5605_C069G12855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000131">
        <property type="protein sequence ID" value="SGZ35062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PQK8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33116:SF78">
        <property type="entry name" value="OS12G0587133 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33116">
        <property type="entry name" value="REVERSE TRANSCRIPTASE ZINC-BINDING DOMAIN-CONTAINING PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ35062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="575" mass="65600" checksum="5133DD9B3EADDD38" modified="2018-09-12" version="1">MMNVFYKKKTDKTLVLPLGPNWLRDETAQALPTVQEGESFKWCGYAFFRHGDSKLFWTHVLDRIKAKARAARDRTLSPSGRVFYANAHITSTVLHVLSFDIPPQWFIQAAETALTDFVWGGPRRNTVARDFVFQAREDGGLGLISIGDIVHSVALRFWDAVAGSDEAIWAPLARESWRSLVAATRDFSPWGFFSSTARVEKLVTLPTIKSELLTLPELLSLPPRLPSLYAEGAKHAYDDADAVAKFAQIADLYWRDEGKGWALHVWARVGQKLKAKALLPKTAVRPARIPLKEDPHPRCFNFFGLTRPFTIRKLRRLVNTVRFPGKDGQDRALPGGQPQEPRVKRFPEGTSQSGRQRFWSWLHDRFASAAEQDTHWRLMYDVTPTRKKQHVQGHASSPSCLFCGNDAAVIETVSHYFFGCAYSASYWSGVLRILFDKLGIEDTDVDPSTTTSKWMWVRLACAIGFQRLHLLRWHVHQRFEKDRVVAPPSIPSALRAFNRDYLSGFVPGARDWRCDDRVNGNLCFWMLDRQAGSIVFGGYKARSFYWIVFCRLPTAQQPALETQPRRDIRRCRGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LRR3</accession>
    <name>A0A2X0LRR3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C086g13014 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">BQ5605_C091g13056 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C091g13056</name>
        <name evidence="2" type="synonym">BQ5605_C086g13014</name>
        <name evidence="2" type="ORF">BQ5605_C086G13014</name>
        <name evidence="1" type="ORF">BQ5605_C091G13056</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000003">
        <property type="protein sequence ID" value="SGY11526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000037">
        <property type="protein sequence ID" value="SGY28449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LRR3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY11526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY28449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="66" mass="7537" checksum="0AB43F2B5B593357" modified="2018-09-12" version="1">MVRSFALVKIYGMAREGRSLVSGQYPRVKARLVSLFWIAFLSAPTAQQPALEIQPREDIRRCRGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LRX1</accession>
    <name>A0A2X0LRX1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C011g06241 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C011g06241</name>
        <name evidence="3" type="ORF">BQ5605_C011G06241</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY11703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="527"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY11703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1411" mass="154410" checksum="C8DD469699F20622" modified="2018-09-12" version="1">MPEVLQRVLESDGRFKHVTTELSVGPEPEQSEFTRSLGGSTVAHVATFRTQHRNYRHDVDDLDQALAQARNILFVCLGEATFARIADQPTHELWAALDKDLGAASHDFARSEKLDALFQYQPYVDGDPLEPCLPARQIDGVKYTQAEFDKWVPPPALSEGIRMDLLKARMPRPIVTGAIRRAAMSRSSGTDVAEALAAKTQGRRRRPARNRALHSASKVPGLMDKWLHGVAQNGRLRLGPSQCRKCYEQGHLGDKCTVPLTELSRHQVAVLAKHNISIGAADAMALVAEYGPDPLVDDDSYKNYFAEVALDTKVSALYLHDGPRYLLDSRATRHMTTRRDLLVNFQPFTTEWVRVVGAFKSSAMAVRKGTLRFDANGTPLELRNVLLVPGLSAELIFIASLMKDGYQLSGICDAAGEHSGLTVSGPASSLTFALDCNHYVLQASPASPPLADHQALTATSLPTDVVLWHQRLGHLSWGHLVELAKSGDISLDISAVTRDQLRLLDQCNACCSGKAVSAPSREAAHHPANAPFARVFANMWGPSPVPALSGVRYLCGVTDEYSCFRWACGIWLKSEASSALNGFAAMSAGPGVATLRMDRGGEFVNNDLRDWLAERGIFHELSAAYKHGQMGIQERSWRTIFNSVRAWLHCSGLPSSLWEEAAQAAIYVINLLPLSPLQQRTPDAVLHAAASPVTSTRCPRIDSVKTWGCATQVPFAPEQHSNKSALRLRLCYFVGYSLRSKACRFYNLVGNKVFESSQAKFFEDRFFPVAANPVPTVVAPAVLSYPSVPRRVPPPNFPPDNDNTVNPAGVAPAVAVAPAVAPAVAVLPAAGPVDIVAPPVPPSLVFSNPGPANAPPVGDLSTRAHRPPDYLGLAHAAHDLEFAVHASVLIKDFDEDNPKVQLYSYEEATAFLAKVDKDNAPSVCAALAGPFRNYWLVAMATEEGALVAKQTFSKLLCPPRVAIMIGSMWVLMVKRDAEGKTIKYKAWLVARGDMQRRRGEQIDSFSPTGRAASHRLLLALAIENEWETRQFDVSSAYLTGNLGGTELYMCLPSGQVVHLQRALYGLVQAGREWYKVFTEWILSSGFTRTDSDHAVFICRAGDKRCFLSIHVDDGLLTGDGDLDGVLTQLKARFEARSTDKVSFFLGQSIIREGKTGAAIATQSHFVDALLEEYNMANASPRPTPLAAPSRLRNRVNSDFDPASIPYHAIVGKLLYLSGTTRPDIAFAVSKAARFCNNFEAEHWEALKHILRYLVGTRNFGIRYQKTHQPMLAILEDFVDADHGANPVTRRSVSGYVFTCAGRAISWIAKHQTLVTLSSTEAEYVAMLYAAREGIWLRRLLADLGFEQTSPTRLRDHIVEGTIEMVWVPTGIMAADVLTKGLGTQKHYQFVHGIGLIASSREGASWCVGNEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LS65</accession>
    <name>A0A2X0LS65_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C011g06341 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C011g06341</name>
        <name evidence="1" type="ORF">BQ5605_C011G06341</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY11968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LS65"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY11968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="139" mass="15100" checksum="275104162BB66625" modified="2018-09-12" version="1">MSDLTRRFRLARTDPLSPVDAIAVLLTHAGSRAVLATHVPFWAFTALSTFPPVDAIAVLPTRELTGGTRNAHSLSGLNCVVDVSLPASMAAFTTCRDRCVPHSQDYLPADEVADREFHLAGRSQLLAARYETLDVARLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LT24</accession>
    <name>A0A2X0LT24_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C011g06671 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C011g06671</name>
        <name evidence="1" type="ORF">BQ5605_C011G06671</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LT24"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY12978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="71" mass="8057" checksum="690ADF77CBC3EB56" modified="2018-09-12" version="1">MAASNIATNSSKNSLQHILFECQPSSCFFTASCGRIDFVRLRIRVIGTPNFFAEPCLYRINIDGSFYFQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LUC7</accession>
    <name>A0A2X0LUC7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C017g08317 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C017g08317</name>
        <name evidence="2" type="ORF">BQ5605_C017G08317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY19794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LUC7"/>
    <dbReference type="STRING" id="796604.A0A2X0LUC7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY19794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="232" mass="25590" checksum="128E236991A488C2" modified="2018-09-12" version="1">MQSLFGPVVLNAPAGIPAPHPSLPRQHPDSSSSSTFGERSTASATSQKRRRKAPIPAPKVPRGLFERAHSKKTKRSVPSADVQRHRAFDQALYVQKLDYCDKNDIRPCDLARITQPSAPAPRKRSDWNAFQYSKYADRLAAEEGIELPPGLMDRQPTTTRYWRRIAGTEADRLECAKILALEYPPEERDADEANDADNVDEAAVSIAYQRPSSLVASDKAAALAAKELASKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LUF3</accession>
    <name>A0A2X0LUF3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C013g07160 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C013g07160</name>
        <name evidence="2" type="ORF">BQ5605_C013G07160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY14904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LUF3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="345"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="513"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="590"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="666"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="719"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY14904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="832" mass="87639" checksum="8458FA36AB168800" modified="2018-09-12" version="1">MDGQDRRASLQLGRQARKEAASPYARPKASPASANAGASASGTPSRLSGLLSYLSPFRRGKKKERSPEPQPASDDEQDHNNDHDHEEPQHSDGSDDDAQHAHAPAFELHGDFIEDHDMHANAPPSPTPYQNIYPNLGSSITASKSMPQLASTLASNATPRPRGGFTSAMPRSATRADLAPFSASAASWGQAESVFGSERSAPGRANEELARFFRDKADRGDEPLTAIEQAGVLHLVQQAKAENLPTAFTPNFGSASPTLSVQPFYARQDSVVPISPSAASNDSTFGGVGASPSTLNAEFTAGHTPYRRRRPIYVGAGYSSRSARRNRTPGSHSASNGSNLTRSQSEGGSLNSLGANSSAAEGKRRRVEAEDAPPAPSTSNLSYAASPGPSAPASPSPAAAMTDSSKTSIFSRAKITANAVSTPVRPSPLWQVSKAETPSPSPPKRVASGTPRSTTRAADMMMDIIRQEDAARPHKISPTTGREAFINPYESTDHNPLARIPRSRPVRPPTPSRPALARVAAQKAASAAPSPKKVSPLEQLERSMPAEYRREDGNRSKLASSVASASPAPTPQKEAAPAPTFAPPSMPVVATKPSTKKAAPANPFAALASETDEADDDEDGSREEDEEDDDEEEDDKEDEENEEEDSDDDIVIIEEVVKKPTPTPKPKTVFIRKAPALKTSAPAPSAPTSKPVDQPASVGPMFGTPSSNMFGQTSLVPSKQPPTGKPAPTPEPAVSFSFGAISAAPVETPKAAAPKHVVSNGSSITLVDSSDAQKQALEASRTSLPTFVFAGTWNTCTGRGEAAEATTRAAQDLARMMSRGEVPTFEFKCSPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LV04</accession>
    <name>A0A2X0LV04_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C017g08547 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C017g08547</name>
        <name evidence="2" type="ORF">BQ5605_C017G08547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY20245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LV04"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY20245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="91" mass="10308" checksum="67D1D80C2DA5409E" modified="2018-09-12" version="1">MPEDSLGTHQAAEETGTSVGEVIIPFRTVLGLELIGCWRKMRCHFTGIFLFGFGMQRWTSVHRLFRVSRGDVLAILLGFLVLFGLNHVNRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LV48</accession>
    <name>A0A2X0LV48_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C017g08510 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C017g08510</name>
        <name evidence="1" type="ORF">BQ5605_C017G08510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY20178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LV48"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY20178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="49" mass="5721" checksum="D12A23FB624F2B59" modified="2018-09-12" version="1">MESDLDEAALQDYNDYEHSGADDEEARAYNLTVIFILQGKCFRPRIRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LX93</accession>
    <name>A0A2X0LX93_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Alpha-aminoadipate reductase</fullName>
            <ecNumber evidence="6">1.2.1.31</ecNumber>
            <ecNumber evidence="5">1.2.1.95</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">L-aminoadipate-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">BQ5605_C015g07889</name>
        <name evidence="20" type="ORF">BQ5605_C015G07889</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+) = L-2-aminoadipate + ATP + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46936"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.2.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12308"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(S)-2-amino-6-oxohexanoate + NADP(+) + H2O = L-2-aminoadipate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12304"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.31" evidence="6"/>
    <dbReference type="EC" id="1.2.1.95" evidence="5"/>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0LX93"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004043">
        <property type="term" value="F:L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014397">
        <property type="entry name" value="Lys2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03443">
        <property type="entry name" value="alpha_am_amid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF1">
        <property type="entry name" value="L-2-AMINOADIPATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001617">
        <property type="entry name" value="Alpha-AR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="19">
        <location>
            <begin position="962"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1046"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="SGY17784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1503" mass="163793" checksum="0C9C31E3AC2F1642" modified="2018-09-12" version="1">MASVNSNPSMQRWLARLTDLPQLVLPTDYARPSGAAMVEAHEKRTIDDRIGNALVRLALYDELGDHSDSDSDSEPEPDQRQSQQNQREGIDQTLAARGARDHRQQSNTPTPFHLLLASFVVLLHRFTGENDLVIATSSPSSPDPLLLRIKLEPSDSFWSLVKRVQWLEQDAENDKVPYEKLLEALGRGKSSEAERGQRQDGPPEAPLFRVRFFDETDETETSFVQQTSLTSDLTVFVTSTAHDSLSAAASGSSLTPSASGTATPTSLRTSLRAPTVALTLSYNSLVFSQPRMATMLDQLLHLVHHAAAHPLDAIGSISLLTHKQRKVLPDPRADLEWTGYQGAITDIFSRNARAFPDRTCIVESLSPTAVGGANRLRSFTYQQIDKASNVLAHHLVASGVEREEVVTVYSTRGVDLVVAVMGVLKAGATFSVIDPAYPPARQIIYLQVAQPRALVILAAAGSLLPPVRKYVSESLKVRVEVPAMQLLASSFLLGSAPAEGEPDALDGVRSKAGQALNIPLGPDSIGTLSFTSGSTGIPKGVRGRHFSLTHFFPWMSKTFGLSETSRFTMLSGIAHDPIQRDIFTPLFLGAELHIPTAEDIGTPGRLAEWMADSKVTITHLTPAMGQLLSAQATRSIPSLLNAFFVGDVLTKRDCTRLQQLANNVRIINMFGTTETQRAVSYFAIPSLSTDPTFLKLRKDIMPAGQGMINVQLLVVNRNDKNQICAVGEVGEIYVRSGGLAEGYLQLPESTTEKFVANWFGTGVEREDLIQSGDEAWKPYWKGVRDRMYRSGDLGRYNPDGTVECTGRADDQIKIRGFRIELGEIDTHLSRHPAVRENVTLVRRDKYEEKVLVAYFVPLMGSKELEGLVSGGEDDGAGADKRAKVTASEVAKGLKKYRRLIKDIRDYLKTKLPSYSIPTVFVPLTRMPLNPNGKVDKPALPFPDTVTAAAATTTTHAAPGSAPTLSVTERAIHDIWLKLLPSPPAQIPTDESFFDLGGHSILATRLIFELRTTLAIGAPLGIVFDHPTVAGLAKELDRLRDSDLGLASGERSAKSGSTSTANDDEYAEDTEKLVARLHAKYEKPQEVEGPKTVFLTGATGFLGAFILKDLLVHRQSQVKKVICHVRAKSPEAAVQRLRESGQGRDAWDEAWVEKGRVEAVTGDLEADKLGMSEQEWDRTAQEADIIIHNGALVHWIYPYAKLRAANVLATLAVLDLAAATRPKVISFVSTTAVIEKGHYVRLGDSLVQQGSKGVPESDPLDAGKEGLKGGYGQSKWVSERLILEAGRRGLAGAIVRPAYVVGDSTSAVTNTDDFLWRLVKGCIQLGHIPDIHNSINMTPVDHVARITAISALQSPSEPLRVHQVSARPPPRFNQFLSVLQRYGYQVKKTEYLPWRTLLEQHVLKSQDNALFPLLHFVLDDLPTSTKAAEIDDSNTIALLKKAGEVETMTVDDGLVGLYLAWLVAAGFLEAPAVPASEGKNVLTLPALRSGQVAKAIGRSSGHAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LXP4</accession>
    <name>A0A2X0LXP4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C014g07454 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C014g07454</name>
        <name evidence="1" type="ORF">BQ5605_C014G07454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY18738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LXP4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY18738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="59" mass="6242" checksum="BB50573BEE5815EF" modified="2018-09-12" version="1">MASICTGRGYVLRVVKTFAQNNFDLLASFAGISSVLVSQTWPPVTENGPAGRKVGCRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LY80</accession>
    <name>A0A2X0LY80_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C014g07452 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C014g07452</name>
        <name evidence="1" type="ORF">BQ5605_C014G07452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY18730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LY80"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY18730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="266" mass="29833" checksum="CFF3744EFDC6D53B" modified="2018-09-12" version="1">MIQQPPRRGSVFAEFCTSRHLSLCQYLSWYFSPSTRFEGVQTHRPKLFNSNWSSLTRVLLEADSINDWIAEQADSIIINEMKLSWVRSHSLATEGTTQHRNGLMTLACGANDRLTTFLYDCGLTTDISLGDSPGSCELDEGELKEIGSSKYFHVTVDNVDVTHHVNDQQLDRRTELLHGTFGSAHIQNGVIAGAYNLRAYSAHQASLPRVISSISSLLPNPTRHLKPGSKFRYIERLLDWFLILASVFAVLDAPPPPPSPRHRRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LYP2</accession>
    <name>A0A2X0LYP2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C017g08435 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C017g08435</name>
        <name evidence="6" type="ORF">BQ5605_C017G08435</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY20016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LYP2"/>
    <dbReference type="STRING" id="796604.A0A2X0LYP2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF90">
        <property type="entry name" value="CENTROMERE DNA-BINDING PROTEIN COMPLEX CBF3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="247"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="95"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="939"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="95"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="939"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="992"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1013"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1037"/>
            <end position="1050"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY20016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1108" mass="119694" checksum="6E2995BA78CD9112" modified="2018-09-12" version="1">MSYAGCRGEGPPYIPPVIVPPPSSSSPWHSHSHSHPGTFPPPSSLSANGGAGRSGFASSSTSTSTSGVADALIPRPRPHVLDQYRLPSLAATFSAASAAATAASGTGSSSHHSSPSSLRSPYSRPSALSGSMSTSASNQPTTPGWGVTPSSSTFTSGNQAGGQGSGGQKPESSIDREDDHDHDHDHDHDHHPISGGVEAGEGSDDQGTGVGSGDEGSRKAERRGSEFKREGSLRFSRKKKRARVVLSCTMCVRRKTKCDKVVPCSACVRRGSPNDCVVEGVDEVAPQPFALNEELVALRSRVNTLEGLVNSLLTASRTSPATQPISSPSYISASTSTPTSHLLPHKAENDEAHVAEALQRLSEGVTNDARSPNAIAARVNPSSNHFRSSGSPELDHILSLIPERAICDLLLESYLLRVDWQLHILHIPTLKHDYRTMWDKLRSPAPATGPESLEAWVPPRLGTFFMVLALGMYFIPPELSPYSAVEAAAMPSKWLDAAEKALGLADWSGRPQLRTVQIILLMGQFWHHLGEIDRFVIWIGAGVRVAQSLGLHNAEQTGILHLPYDDFPIKTYARDFFCREMGKRSWWSLCADDWDVSYRTRNVSVLRTQDFSTPSPFNLTDDDLMDGPVPSRNLTQPTSVTFQICFSDLIYLSQQWRQPHREMGNIGNLSIETVISLDEIVRGMSVRFPFYLQLEKKDDPAVKVLEQAHPLVAIQRLHLAKELHCRYVRLHRRALFGDDLGTAQARVSRSTLRSSASTLLSIVAEFRAKTDYAHKLWWVNSYMTLAAVALLFSNIQHLISSPTPVASSVLNDAASKRHEVLTTLTLTRGTPPLSPHTVQGLRIIDLLLQEENVIVANAKRATVGGRQLSERDAERYYAAMDVVAKATMCVAERETLRLKDLADHWNDFEPRPQSVLQQQQQIAAQGGQQQQVGQLIPPSGIQQQQHQLQQQQQQQQQQATATATQNATSHVGGGGGAPMLVVPSPHGAGGANYSTRSNNGGSMSGMQTPNDGAMAQQHHQQQPQAANYHLSSSSTSLDFSNPQAWGTTAASGGPQGYANTPAGVGVASTGSTGAGAGAGGLGGLQAFQFPYDPFWTQDGGWDDFSRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZJ4</accession>
    <name>A0A2X0LZJ4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C016g08213 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C016g08213</name>
        <name evidence="4" type="ORF">BQ5605_C016G08213</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS21 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY21235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LZJ4"/>
    <dbReference type="STRING" id="796604.A0A2X0LZJ4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1230.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1230.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001931">
        <property type="entry name" value="Ribosomal_eS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018279">
        <property type="entry name" value="Ribosomal_eS21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038579">
        <property type="entry name" value="Ribosomal_eS21_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10442">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01249">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00996">
        <property type="entry name" value="RIBOSOMAL_S21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY21235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="112" mass="12475" checksum="E00EB65905644B4E" modified="2018-09-12" version="1">MQNDLGHVVDLYVPRKCSATNRLITAKDHASVQIAIAEVDDEGKMTGSSVTYAFQGSLRETGDSDDALNRYVPHELWLVVERIMVLISFDSFVAVRLATGDGLLKQTWSYQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M000</accession>
    <name>A0A2X0M000_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C019g08886 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C019g08886</name>
        <name evidence="1" type="ORF">BQ5605_C019G08886</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY23041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M000"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY23041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="201" mass="22310" checksum="49BE91159C913485" modified="2018-09-12" version="1">MHCGAGFQEVVPCELRQDPKYLENYEVSASGRAWQETRSSLTRFSYYDATMTIKLFAISELAVRACLDGQDLCFDESQGRAQASGHSSQGVPGERLYMAILTWNSTGGCPCACQILGRVDAERGAACTAARARLAMTMRRNLPPVPRASTVRKVDFSMCRGLGAFKQKRTQNILHSIVIPVEGKERFEVRQTGAYFCPLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M0C3</accession>
    <name>A0A2X0M0C3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C019g09025 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C019g09025</name>
        <name evidence="7" type="ORF">BQ5605_C019G09025</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TTC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY24250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M0C3"/>
    <dbReference type="STRING" id="796604.A0A2X0M0C3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044059">
        <property type="entry name" value="Csn1/TTC4_wheel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18972">
        <property type="entry name" value="Wheel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Cns1/TTC4 wheel" evidence="6">
        <location>
            <begin position="371"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="326"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="337"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY24250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="491" mass="54539" checksum="1342849252F1B691" modified="2018-09-12" version="1">MTCHDAVGPSERKSFAAWNPERDYVSARLSSTSWLSDRLLLDGYFTKWPLHLQDLQSRSSLRELRRGYGATRIDHGKAILRSSAGKDDPFAGWDTTPLFMQALPSDGALNDASGANTGQNTLAALQALAYDGSPSEIAEEFRNQGNQLFKQRKFKDAIGFYSRALDELGQDLSVEEKRTLWSNRAAANLELANYGSCLRDVAQVLGAPQTYYPEPMPEAWKRTDAKALLRSARALLGLDRLDEAFDSLLRLQVLEERLGEAQLDSGKKWREQVRTKIQQRERLELEKKEKERRRKEEEQALVLAMTLRGVALPKITASKPLFSECPSDVRPPHFDPKSLPSSSSPSIPLLPPKADSEASSAAAIQWTAPPPETSLIFPIFLMMPLNDPPTRDLCLEFHTAATFGDLLVSMDQDPITIAMYIATKEGRVLKVGNKLTLGKVLVAAAGEAADDGWELKEGWALELVAVPKGPRGEEWVAKWKQEVKASVKPLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M1H0</accession>
    <name>A0A2X0M1H0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C018g08747 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C018g08747</name>
        <name evidence="10" type="ORF">BQ5605_C018G08747</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY26572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M1H0"/>
    <dbReference type="STRING" id="796604.A0A2X0M1H0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045145">
        <property type="entry name" value="PTHR15271"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271:SF4">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="9">
        <location>
            <begin position="245"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="60"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="384"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="199"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY26572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="417" mass="44435" checksum="C3B814249F835B48" modified="2018-09-12" version="1">MSTATLQSPASAFVPSTIRSVGGSGGRVETLRLYTDSNATFYFRRLAWSPDGSLLLTPAGIFEPPNESTSTQDQPMRNSIPSTSSTKRKANEDEIPSANASGPRPTVYLYSRANITRPPIAHLPGHRTTSIAVRFCPVLWRLRDFNESGVRHGEGLGEGLQSQHEVNEPCVMIDLRRGETVCADLGRPSAASTSKAEDWDGDGDGDGDEENDDCVVIEPRLSGGSEGLRGPKQASISDVLPSPVVLFDLPYRMIYAVATMDCVYLYDTQQASPIAMFANLHYAPFTDLAWSPDGQTLVLSAEDGYCTVVAFDEHELGIPHDLDGAHELPALPATMAAFDGPIAVQPPSEFATVTTPAHAALPALFASMTGGTALLEVPGDKRAATNEAGHAPTNEPPKKKKKAVLVHHGPLGSSMTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M1U8</accession>
    <name>A0A2X0M1U8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C080g12970 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C080g12970</name>
        <name evidence="1" type="ORF">BQ5605_C080G12970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000035">
        <property type="protein sequence ID" value="SGY28298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M1U8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY28298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="308" mass="34152" checksum="4E9C2F27979CCCA1" modified="2018-09-12" version="1">MTYCEIFKLKRGEVELFLGMKIATDDASGIMTIDQCHQIETILNNHGFANASAVATPTSDSDQHSDGGTAHLKLNYRQVVGELLWVSGCTRPDISYAVTQLSRHCADPKPEHFRQMRRVLRYLRGTINRRLEYNRYLGIDVTLYCDSDHAAEKSGRRSISGYTVIMAGAAITWASKRQVSVATSSVQAEYQALSAAARETLWIRSLLFSLGFPPSSPTIIHGDSTGAIALADHPTSHATTKHIATHYHFTRELVSNGIIELRWIGTKEMVADGFTKGLSRAPHESFVRMLGMVDAPRQGACWKGLREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M3F0</accession>
    <name>A0A2X0M3F0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C002g01641 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C002g01641</name>
        <name evidence="1" type="ORF">BQ5605_C002G01641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY34493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M3F0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY34493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="57" mass="6392" checksum="99B311DA3F37CD62" modified="2018-09-12" version="1">MHRRALQSQRLGREPSPPPHLLILNLIRHSSPLPSPIASPLASPDPRGYETVAFVMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M3W4</accession>
    <name>A0A2X0M3W4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C001g00620 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C001g00620</name>
        <name evidence="8" type="ORF">BQ5605_C001G00620</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY48154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M3W4"/>
    <dbReference type="STRING" id="796604.A0A2X0M3W4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF12">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY48154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="122" mass="12707" checksum="B6CFB27074882652" modified="2018-09-12" version="1">MAVSTAVLAFSINHSLFGLASLCIVLFVATFSIGLGPIPFVLMGELPPPEARSATASAALGTNWGLNFIIGLTFLPLRDFLSGGRTSGSGTIFYFFSIISAVGYLVMARRLRATTASTATAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M404</accession>
    <name>A0A2X0M404_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00653 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00653</name>
        <name evidence="2" type="ORF">BQ5605_C001G00653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY48457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M404"/>
    <dbReference type="STRING" id="796604.A0A2X0M404"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050849">
        <property type="entry name" value="HAD-like_hydrolase_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006384">
        <property type="entry name" value="HAD_hydro_PyrdxlP_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01489">
        <property type="entry name" value="DKMTPPase-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181:SF2">
        <property type="entry name" value="PHOSPHORIC MONOESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181">
        <property type="entry name" value="UPF0655 PROTEIN YCR015C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12710">
        <property type="entry name" value="HAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY48457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="251" mass="28127" checksum="497EC4E8AB3AA09D" modified="2018-09-12" version="1">MSASSSLLPHAQAPYIVFTDFDGTITTEDSNDAATDNLGCGLEKRRAINLEVLNGTRNFRDAFREMIDSVAANKTFDETREYLRNRIKLDAGFKSFFEWCKAHDVPVVIVSSGMVPIIRAIMENLVGKEDAAKIDIIANDVEYLPDGKWTIKFRHPESGFGHDKSRATSPYRDLEHKPTLFFCGDGVSDLSAARAADLLFVKIVPGHTNDLSVHCDREKIPYVAFEQFLQVKDAVADVIEKRTTIEQLLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M516</accession>
    <name>A0A2X0M516_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g03789 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g03789</name>
        <name evidence="2" type="ORF">BQ5605_C006G03789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY53680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M516"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY53680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="87" mass="9550" checksum="C3C81467997BADCE" modified="2018-09-12" version="1">MFADIFTKALGPKLFIFHWKNSGLRGAVLLILVASRVSSMPRAYFLSASLLSPTIFTIIFGSCTYALCAWASVPESTHPNVTQRLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M5H3</accession>
    <name>A0A2X0M5H3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C006g03949 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C006g03949</name>
        <name evidence="25" type="ORF">BQ5605_C006G03949</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY55017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="534"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="241"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="785"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGY55017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1400" mass="153968" checksum="923A8649A80B9FE0" modified="2018-09-12" version="1">MSHTDLPANIALPDSDDENSMAGNDETGTPPPPPSPLSSQPNIVVPPMHVLLTRERFDDLVKKRRSVDDDDVSKRNLLPPTSPPAFPDESKLSDNNYVDWDLTMSLTVPREVCLYLRTGCHDKAWLPELHSRWEDYAARVLAGSLTTVAKGTIGPVAQKGGNAHACWVALTKRYAPSDAQSHSMLIRDFFNMPKLPSTWASFNKWMNRAMPNKSKLPVVEEIFASMESVACTLRNESTPALVAQTPSSTTKAGQNRKGRWDRSGPPPGNCPACQQGKHWVEKCPDITRRNKYLELKAALKEFKGVSPPSAPALAANDNNAYMAFFAAPAFVNLSKSANLLLDSASAYHMFNDSSLFNGPISPASHVMQGLGGTVNTSGIGSVKLITDSGTKLILNDAIYVPESPANLISVWAFDRKGVRITVQKGHVELSTAKGCIATATAIESRVYKLNATVEVSSKGAPPAYVTTASTRPPLLTLHHRYGHAPIQAIKRLAASGQVKGLDWTHSDSKCVEFTCNACLASKAHRSPFPSSLSHVAKPLALVHSDVLSFPEESINHFRYLVTFVDDYSRKTWVYPISHQSDVLPTFKDWLLEIENATGRRLKTLRSDNRGKYISSAFNGYCAARGIRHKLTIPYTPEQNGWAKRVSIVEGTLAFLSHSGLPHLCWDEAAVCYIHTKNLSSHVALKGGVPNHCWSGTAPLVTALRAFGCRAWATVPGHRRDKLDPKGIPLVFVGYDCHAKAYWLLDPTSMCVSLSRNVKFVETKFPFLSMPKRATAPSIPGYRPIAQPMLQPEGPRATPNQLPPPNDELPAPDDEAASVRSDVTNAAEVLPPPEQVPEPPAKVKPAWEYGDLAGPDGPTNAFKNLILAFTATTEGFAEHDLAMVCDPANWGDVIRTGQEEVWHPPARDKFDSLLNEYEVFEIIESCDLPSDEILLRSGWVFRTKRNQHGDITDHKARLVAHGCSQRPGLDFEKNYAPIVKFTSICALIALAAANGYHVHQADVNKAYLHGKLDKPLYMRVPQGIDLPGKILKLSKSIYGLCQAGTIWNAEIDSTLCSLGYIPTKSNICIYRRDHDGHSHYIALYVDDLLLVGPSVAKIDQVLDALELIYGIKRLSPAEYILGIQVKHGQDGSITLSQERYLRDLLDKFRLGNAKPASIPMQPGVVLDFQDAFATPQDRTRYLQAIGLLMYAAVGTRPDIAYVVAYLARFSQQPSPAHWTAITQVLRYIKGTLDLGLTYRKNNVTFHGYLDANWGACLTTSRSTMGYAFIYSGAAIAWCSKREHRVAKSTTDAEYLSLSYASGDAIHLSELLAELGHPVPGPVVIYGNNQGSLALAQHPTNHQGSRHVRISKHYVRKRVAEKEIDIVYIATADMFANIFTKALGPKPFLFHRENLGLRGTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M5P7</accession>
    <name>A0A2X0M5P7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C006g04019 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C006g04019</name>
        <name evidence="3" type="ORF">BQ5605_C006G04019</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY55411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M5P7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY55411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="685" mass="76665" checksum="D7C9C830659130C2" modified="2018-09-12" version="1">MLYSGDSTTARYIINGFLTPPVRLTCGLGQGDPASSSVWDVVFQPFLDALHRRGIALNLSLPTIHPYPQSRAITSLAFADDVVVAVAGSESLTLLDDLALDWRLATNGRLNTDKTVVLPIGCRWEAGDRPLVVKAEGESLEWIGLSFDPTGNTELANVNLVARLEAVLDSARDRGLTHHTRAFYVNRYAIPKILHILSADIPPLEVVKELDRILVDFVRGGKRRSCYGKDVVFTPRFKGGLGVMRMQDVVDSVAARVWDVLLGGSDAIWQGLARAAIVRAHPAPDFDLATDAWPCDYTPIRTDLHPRWQAVLKVPSTHNAQVKPRTLTLANLLALPIKLHTLHYLPGAPAVSRSPYDADYAAFANYAKVADLFRRELYPGGGFHLWTPPTDVVVSNSEYDQRGRPQREHIVAWYRHAINRLRFTPIAQPVAAVRINGPPRVRPRSEVRPTTPLESILPHPIDPPQRLPRPALPDQSTQYNLLSMDRPYTIRRVRRVLNAKAFTDTIGFRDSLQPDDLKGFWKGVNSKALTAREREVWFKLVRNFTPTRSLQFHQKHDDSPACLVCGAPKDDREHYFFDCVDSGNVWIAARSVLCDALGLDTIDNTHYTAVQRMFGLPKLKASLRDQEGAGRTIEIFTGLVLEMISSGRWGMQKWGTRMEGVVRRRIILEERLKLRAGGAWGRRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M5S4</accession>
    <name>A0A2X0M5S4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BQ5605_C006g04036 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C006g04036</name>
        <name evidence="11" type="ORF">BQ5605_C006G04036</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY55503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M5S4"/>
    <dbReference type="STRING" id="796604.A0A2X0M5S4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000003">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="8">
        <location>
            <begin position="346"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase RNase H-like" evidence="9">
        <location>
            <begin position="509"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase zinc-binding" evidence="10">
        <location>
            <begin position="675"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="49"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY55503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="766" mass="86345" checksum="C573278361FC27F9" modified="2018-09-12" version="1">MSETDVYSDAPADQPGKFDYQVFERIGREEWGVIAQRRAAIATQVAALQQQTTTEAPHPTDSLRNGLDDATRSHHHPSLGGTPVPSSPPTRPSSLASSPYVRLTSPISLPLRDTELALLGRDLELILGGNFIYMHKIDLGHFPHPHLTCKNNPEEPIDLLELSSQPRATSPVAAIAPINEDEQLRLAALDRRLRAVYADRFPDNIPLVATYQSPVRHHIELDNPRTVINLRGYPVAKRHRQAWYLLLQKHLASGRLRPSRSPYASPAFIIPKKGSDVDPTIAPRWVNDYRHLNRHTIKDRTPLPLADDILSTCSKAHFWAKIDMTNSFFQTKMAEEDIAKTARRVNDALHGLISTICFVYLDDITIFADTLEEHEARVCQVLDALRRAKLYCSPSKTNLAASECEFLGHIINRSGVHADPKKIKRIHDWHLPATVTELRGFLGLVQYLRKFIPGLAEHTAALTPLTIKGLTFIDNLWTTPTVCHFEAIKSIVVSLDCLRPPDHSADAMPFWVMTDTSLQGIGGVLLQGSHWKTAHPIAHWSRQYIPAERNYPTHEQEPLAIVEALKEWRIDLLGGHFHILTDHSTLEHFQTQRTVISRRQVRWLDTLAESDYDLQYLPGRENIVAEAMSRYSFPEPLPIIVTNISQLLLSDVVKQEIVDAYKTDAFCQQDLNNIALHDAHDALGHLGDVKMYQTVIQTYFWPNMSRHIKQYVQQCDSCQLTKARTTRVAGKLHTLPVPVRPMADIAVDFVGPLPTSCQQTRGLTGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-03-27" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M620</accession>
    <name>A0A2X0M620_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C001g00179 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C001g00179</name>
        <name evidence="1" type="ORF">BQ5605_C001G00179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY44594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M620"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY44594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="125" mass="14005" checksum="CAE0CC6945C7ECBC" modified="2018-09-12" version="1">MTKAVGRWGNVLPRVNVDKASARLSEQMLARFKRDAPISLTTRLTQFATRTPFIQLSSNLTGVRVESIKIVSFLYFITRFLYNPNYIYGTSAKVALLRSLLWGTGQIASLWLLKRSAAGPKTPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M6B2</accession>
    <name>A0A2X0M6B2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C001g00279 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C001g00279</name>
        <name evidence="1" type="ORF">BQ5605_C001G00279</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY45392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M6B2"/>
    <dbReference type="STRING" id="796604.A0A2X0M6B2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02970">
        <property type="entry name" value="PRX_like2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032801">
        <property type="entry name" value="PXL2A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630:SF3">
        <property type="entry name" value="PEROXIREDOXIN-LIKE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13911">
        <property type="entry name" value="AhpC-TSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY45392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="212" mass="23177" checksum="16F4666B2E15A2F1" modified="2018-09-12" version="1">MATQEFDSSSAPSEATLATALAATIKDHTGADVSFGSLLSAERAHKTIVIFIRHFYCGLCQDFLFFLTSKVKPDLLQSHNTKLIIVGCGEFGLLDGYKALIGTPYDIYADPDLSVYTPLGMTRRTLEQGKFGPNNKPEYLVRSAFSNIVTSIRNVFKMGKPMANSGDIRQLGGEFVFDSQKQAVFVHRMENTRGHAKLTEILGAAGVPYESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M725</accession>
    <name>A0A2X0M725_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C001g00358 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C001g00358</name>
        <name evidence="1" type="ORF">BQ5605_C001G00358</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY45916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M725"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY45916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="54" mass="6153" checksum="CC0F2D187DBB4CC5" modified="2018-09-12" version="1">MCTPASTQPLQGPWPMDQYPCSLDYINYHVNGVEQLQQHQSSPPPAPLWQRSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M863</accession>
    <name>A0A2X0M863_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="23">BQ5605_C006g03795 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">BQ5605_C006g03795</name>
        <name evidence="23" type="ORF">BQ5605_C006G03795</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY53733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M863"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0229">DNA integration</keyword>
    <keyword evidence="18" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="16" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="15" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="16" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="17" id="KW-0917">Virion maturation</keyword>
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        <location>
            <begin position="570"/>
            <end position="744"/>
        </location>
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        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
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        </source>
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        <source>
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        </source>
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            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
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        </source>
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            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="SGY53733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="975" mass="107180" checksum="C1B0F47A057B038C" modified="2018-09-12" version="1">MRRSPLLSGEVETRTEVMRRKLRNRKGARAGIGPAAGEIAGALKQSRASKSSPQGGGLAGARNARGAPVELRQCVEKTFGPRALVKTSGTTRTAFPKHARLDGAKTFANWTRQLRLCLADDIRSYVLDGIVPNDWTPSQRSARNIVAREILANLINSAEVSAVLDKIPTGDLTAPKIYSTLKSSYAPDDATRTLELFSRLWGFRPMPGTVGEFDAWIMEFKAVAQEIIDTKTTINDVLATLLLTIAHPSLESFKATFTDEQRTQRTLPDIDSLADRMQVQLRSTNIPGTQSALLATSSSRSTRPTCLACRSPLHRIAECSTRAQHPPPGPCCSFKKKGHWSLDCKKTLEDSKKHDTADSTVHSQHHVGCLATGLLARRRQLRNNSFVVDSGATSHMVSDKSLFTTYRHIAPTKIGGIAGGINAIGKGNIAFVAASGHPITLTGVLHTPGLSVNFLSVSRLCDSDNVRVAFTKHGIHIDKDGNDIAEGARLDEGLYLLDADHSKCQHLALLSRPQSSVPLLTFHRCLGQLTPSSIQKMVAAGLLEGLGGGYSDKEVEKFVCNACLSAKGHRLPFPDSDSHSSERLGLEHSAVLSLPERSLTGKRYLVTFLDDYSRKLWAYAIGHKSEVFGVFKTWLAEVELETGATLKVLRTDNGGEYCLRAFTDFCKARGTRRQYSIPRTPQQNGRAERVNRSIVEGVLALLADAHLPKTFWEEAAAYFVYCKNLCQHSALDKATPTSVWQGERANALALHPFGCTAWLTVAPELRSKLDPKAVRVLFTGYDLASKAFRFYDTMTKKIILGRNATFLDTEFPGLHGNSTEQDADTHFASAPIAEPQAVVKTWTPLPQACLAPLDVHRPDFSTYREPASAEESPDELDLIGRHSCDESPDEIDFLTRHHRAFIATDDDTSDAEAIQPVKSITSDPQTWREAMSSDIFDQLYYISDVVIAKSDEYITTYLFDQLYYVSNVVIAKSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M883</accession>
    <name>A0A2X0M883_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C004g02610 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C004g02610</name>
        <name evidence="2" type="ORF">BQ5605_C004G02610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY65983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M883"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY65983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="263" mass="29977" checksum="B4B223C4ECB5C299" modified="2018-09-12" version="1">MTPHVQWQYHQCLLSLVERLVSAKLYDEHCLRLNVPFPPRRLGAFASSPLSSRSLTQLATPPRSNLCVRLHVNSILKSLPSMSSRNSATIDWRGCAEQAEGDLELQQLEAERDLACAQRDVLQARVAALETANESIRGRNEYLENRDRVKVEHGNRKRVLNTTQPSNNDNHTEHLSTDPTCLKLQNELQVYVRQEAIKDHLHLMKLDDSKDDPEVNINTAALREVKIEAAHGAMAKIEQRSNGAVKPRMAHRDYSERRRSRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M893</accession>
    <name>A0A2X0M893_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C007g04880 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C007g04880</name>
        <name evidence="5" type="ORF">BQ5605_C007G04880</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY64183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M893"/>
    <dbReference type="STRING" id="796604.A0A2X0M893"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669">
        <property type="entry name" value="5-KETO-D-GLUCONATE 5-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G03445)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY64183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="335" mass="36546" checksum="02B9AC87E20F9B61" modified="2018-09-12" version="1">MSSGKPCRGPSCLLRPLPLPVTHLSFSPLRRLLLFPDHPQANPPNMSLPMTQPGIAVVTGASSGIGRACSIALAHAEWTVVMSGRKEKELEETYKRAKEGKQVKEMAWVVGDLGRREDVIKLFDFVREKYGRLDLLFNNAGRATAGCQLQDTPYEDWESILAINVTAVSPSILPSQPPKLAHLTHRFDPPQPFLCTQEAFKIMSTQSPKGGRIINNGSISSYSPRPFSAPYTMTKHAVAGLTKSTALDGREHDIACSQIDIGNAESKMASKDNAGKLQPFGEVRDEPVIPVEYVGATLVYMASLPLDVNILNQVRFFLSRGFGRESLADGGFVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M8P8</accession>
    <name>A0A2X0M8P8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00937 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00937</name>
        <name evidence="2" type="ORF">BQ5605_C001G00937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY50907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="858"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1008"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1114"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1218"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="452"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="536"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="648"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="741"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="759"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="871"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="903"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="959"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="975"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1115"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1237"/>
            <end position="1247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY50907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1311" mass="137945" checksum="AB810F2689774A3C" modified="2018-09-12" version="1">MGFFSRSKNPKSGSNSTSNSSSPSPATASPGGSHASTSATTKFQSSTKPKVAGPHYPSFDEEQSSSDPRAGAVPRRDLAALSTLPSSGTSTEPRIKKSASNFSLEAAAASRFNPFKNRFNAASTSQGPSSTSLNASTSSENIARDRYAEQRGYGPSMTESSGVATSQSTNYLSTLGHSSSRPPSIKSSRSKRASIGMGLDRWRLFSRSTNALNDMNNAEDDDRPLGTLFANENTGSDFIEKQDSASPNTATSPTSRWKLPIRRTSSSAGAGAEGGFVVQSIRNVSRVQDTDYENRPPLDHHRSSSTSSVTLHRSTRGITAMSPLPAPVPDRQGRNGYGDVGMGPRPNLNIRTNSVPGASAWRDNTVEKAPSPTMISVEAFRNATRPSSRTGHRNASAISISSFEEINFPSERPRFEPTRSRRGSYQSLSSPNLDLGSAFGGLPRPAFATNGSASHSRTSTSSSMDPLPLAASSNRSASMGLQPSVPDATTSSSALRSGSTSRLSISSFMTANDGGSLDRRLSSNEDHVSAEHHARPASQPISRPASRPSSPTVFSIPQSSSTASDAELRLIAMYGEPNPTTTEFPSISLPDKASRTPFFLGDGPTSGEEDAGVHGSGTLQASLTAGAHSPQTPLPNDGVRRFDEESSAPTVAVQPPTPQVPLRRGQYQARRASSSSAVETRSPSRLGAGSARGHAAWGMASEKSDSEDEGDTGDKDGHRPEMSKILTSKSAPTPLLQRQEVDEDDEEDDNVPLAHIRSRSSTDLTHFYSSNPDSHSSGLHMNRGPVSADVEVLAELDGVPSETLRRSPASFAMRGHSRTFSAGATTTLASSAAIPAPTIARERTSLSQGQRSISDLSLSMLRPSPGGHTYSSPASPVPSKASVPDTNSMRASPPLPKTPILRSSHGSAPRDSPSSSSFSSNTAGISSALSLAPAPSSSWFPTTTTSAMTSATSPAISGLGTSQSQDTLVNSISSDQDRSRPTSRERSPIIVKFKDLPVLDGERDILLAPPPIKGCNKPSGGRQANHTPAPRFVPKPLPRSSSSLGFSHETPAGSGRGLEAAGATRPASRSSMIAPPSESEVLAGQTVFDRMKQRHRVEAIKAIQLGKDLNGAAVQDEEDGDDDDDEAPLSTLPLRGPSGLNPRAFEVRAPTTFAPQSSYGGFSPLTNAPPGVDQSLYASLPNDQKMQLHQRSQQMMQMMAHAALQARAESVMNGAYSDSKSAVGGVRSPAVTENKFSKTTGSPSPQAQGYAALPPQSPYGYMTHSQSLTNVQSYPSSPMFSAPGSPASPYLYANSLYPSSHNLPAVLGRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M9A8</accession>
    <name>A0A2X0M9A8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C011g06285 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C011g06285</name>
        <name evidence="1" type="ORF">BQ5605_C011G06285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY11829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M9A8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY11829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="354" mass="39438" checksum="F5E7CF4FBE662A14" modified="2018-09-12" version="1">MYLDNLDIELHDDDFERMAPLLDLSWSTDEPLEFDTLPRPFDAWRSKFKDRGAATAARSIWRQIDYAERMRSIVISSQKWMEIYLGVDIESQPLIVRALKVLPPLLVEEQYTPSMILGCSASLHTLLDFKGLVVLDPKERKLAVQQAYDEADAQAEERFLLDAIETADENLPGRLVLDLKSLIEHRRAHQCAHLKAVLLKGRHGASTSTAQDFDPTSKAKLSDHGEVHSSVLRGLVQSMGAARLEAMSGVARSIRWTGQGTFSRFSTANETDNIGYIEDGRKEVRMQLRARQYTVFAKIPTFGSIDGNVTSAMLLKIGSLVCFRLKRGIIPGSCDASNIGEEQLSIGLGSCISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M9E6</accession>
    <name>A0A2X0M9E6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C004g02980 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C004g02980</name>
        <name evidence="2" type="ORF">BQ5605_C004G02980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY69239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M9E6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY69239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="445" mass="48238" checksum="F1A528294671E815" modified="2018-09-12" version="1">MIPSSPYSLLPRRPRSPPLRAPSPLGQASLILHADGSFVPLPHYRGSSVPAGWISPASPQRPSSPNSGSPPLRPPLLVAQSISRQELQKINCDELQLRLGNVLLEFQKQALALRAIQTKISRSWTVPQRAVRGRMKLIIEQFTTNATYLSKYLSSMAIASRQILHFIATCIRETHGLTDFNHVQDLKPVIDELRLLHTQWAALTRANEVFGETLSNATMLFEEAMDPDHWVPTSPLSLETTSLASSHNALTLAFSHVSTFLHSLAITEWQPPLLSPNDVKLAAGQWRDVERVSAQAAKEVRGPVKGVLEGAVVCAFVAREEAERVWKAFGEGLVVVVGGTLPRPFAPVWEWIGAGEMMLEGRGEANQSSVVDGQEQKSPIGVETVDSMEAAAVSGATTPSEISSPPPPRNTREAQVPVNGQQASAAAAIAGESILRPLSTTPSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MAA6</accession>
    <name>A0A2X0MAA6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C011g06545 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C011g06545</name>
        <name evidence="3" type="ORF">BQ5605_C011G06545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MAA6"/>
    <dbReference type="STRING" id="796604.A0A2X0MAA6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="401"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY12577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="457" mass="51100" checksum="D852826159FE1178" modified="2018-09-12" version="1">MKVLTGQFVSAVEADNPAPSDLFYMFQHSSGSKFYGIKAMIKPKASLPKKTLSYAGHTEALMEVKQLEGVVFNYHQGRDWKHYMRFLRKLAKDSQLGFDFMVLYNNKYHKQLTDPNKLVHSLLASRQQCLRKTDQQMASSDNSLSQRGPACGEPRLLIVLLFNRGENHIEEDCLYRHICSSCKGGHAANSAVCPNRHLQHGGRLDGVDSLAPDKSSPSVIMYQRQFHFDTPSKDHPTTSLLSSTSSLGRLPGPLDCASFTNERLATIAETQQLYPSQFNFTRTIDDRYLGQLLAEHPNTILVNSFISAFRTDGFEPQHDGSDARGDDPSTVRFPKSEHHRDLIQATIDKEVTKRWVSPGSAFPLPGVTYNSIFVVELANHRMRVVADHTSSGLNDGIQRCMILSSISFACFVGILDISLVFKILVMSKRWQARQGIAIKRKFPDGSVHTSATLPLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MBQ9</accession>
    <name>A0A2X0MBQ9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="11 12">3.2.1.106</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BQ5605_C007g04644</name>
        <name evidence="16" type="ORF">BQ5605_C007G04644</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(4)-(alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:55988"/>
            <dbReference type="Rhea" id="RHEA-COMP:12806"/>
            <dbReference type="Rhea" id="RHEA-COMP:14355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:59082"/>
            <dbReference type="ChEBI" id="CHEBI:132537"/>
            <dbReference type="EC" id="3.2.1.106"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="11 12"/>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY62041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MBQ9"/>
    <dbReference type="STRING" id="796604.A0A2X0MBQ9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.110">
        <property type="entry name" value="Glycosyl hydrolase family 63, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031631">
        <property type="entry name" value="Glyco_hydro_63N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038518">
        <property type="entry name" value="Glyco_hydro_63N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF11">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16923">
        <property type="entry name" value="Glyco_hydro_63N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 63 N-terminal" evidence="15">
        <location>
            <begin position="42"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="14">
        <location>
            <begin position="292"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="14">
        <location>
            <begin position="472"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SGY62041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="842" mass="95456" checksum="ACF8A905DBEA250D" modified="2018-09-12" version="1">MIGFGARALKFRLVAPTLPTSRFAQTVDLNLVMAVDTAEDSSLLWPTYRPGLYFGLRPLLPHESLLYGLLWYRAPTSSSTTDSSSLSAPPKATKLDTKDVRHECTQSPGLTYEFKRHDPRMGCLQTIADDDLGIAMDVGFAKSRDGNGWGVRIEGKVLHDDDKHLDRASRPDQFEFINYFGRDSEQGQLELREDAPDGTVIIAGEMAGLGKFEIRVRSDHGIVSTKKYGFKVAPGEIWKAKDIIVDAINSQVLDGHTVEVESTLYAVHTTVDGSWTIDIFFNSDSGTTHMDTSSLTALMDSNRLQFHNRFRSCFELDRFGNFEASEVAFARSTLSNLLGGIGYFYGTSIVDRHFRYPWDREDGEDKGEAKPHPEIVPAQTLLTATPCRSFFPRGFYWDEGFHLLLINRWDLELGLRIISSWVDLIDQDGWIGREQILGEEARSRGGLPRLVALGAWRNSESTDQLTPSRALRSQVPSEFVPQLPAYANPPTLLMAVRTALQLVQRSASTSSSDDMKRTRSFLTSIYPKLKSHYEWFRRTQRGQISGVRGRQARNSEEAWRWRGQSLNPDQLLTSGLDDYPRAEPPTRSDLHVDLICWMATFAESMKELAGACGEGEDRARFEKEFEDVKGNIDDLHWSEEHQLYLDTTVDSRNISEFVVVRGYVCLFPLLLSLIPVDSPKLVATLEFMRDPQYLWCDYGLRSLTPGEKYYGKDEDYWRGPIWIPICYMALKALFTLRSSIFVLFCQTYATTPGPYQGRAQKVYIELRQNLIKNMYRVSSKHFPRSGQGEYKRTGFVFEQYNDKTGKGQRSYPFTGWSSLIVLSKSGVDQGLGRGFVRPVRSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MBR8</accession>
    <name>A0A2X0MBR8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 20">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="14">IMP dehydrogenase</shortName>
            <shortName evidence="14">IMPD</shortName>
            <shortName evidence="14">IMPDH</shortName>
            <ecNumber evidence="14 20">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">BQ5605_C007g04654</name>
        <name evidence="22" type="ORF">BQ5605_C007G04654</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14 20">
            <text>IMP + NAD(+) + H2O = XMP + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="14">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="14 20">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homotetramer. Seems to be able to form heterotetramers composed from more than 1 of the 3 IMPDH gene products (IMD2-4).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14 19">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="14 20"/>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY62117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MBR8"/>
    <dbReference type="STRING" id="796604.A0A2X0MBR8"/>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04601">
        <property type="entry name" value="CBS_pair_IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000007">
        <property type="entry name" value="Chromosome 19 SCAF14664, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF111">
        <property type="entry name" value="INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 18" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14 20" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="5 14 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14 16" id="KW-0520">NAD</keyword>
    <keyword evidence="9 14 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 14 17" id="KW-0630">Potassium</keyword>
    <keyword evidence="7 14 20" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="21">
        <location>
            <begin position="133"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="21">
        <location>
            <begin position="195"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="14 15">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="446"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="460"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14 16">
        <location>
            <begin position="291"/>
            <end position="293"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 16">
        <location>
            <begin position="341"/>
            <end position="343"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14 17">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14 17">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14 17">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="381"/>
            <end position="383"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="404"/>
            <end position="405"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="428"/>
            <end position="432"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="527"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00062187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="SGY62117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="546" mass="58238" checksum="6B9A8D6941FCC38A" modified="2018-09-12" version="1">MATASSSSSSSSPLLPASEALAHLKTYAQPDGLSLRSLMDSQEHGGLTYNDFLVLPGHIDFPSNAVSLESRITRKTVLKTPFFSSPMDTVTETDMAIAMAIMLLGGVGVIHHNLPPQMQAEMVRAVKKFENGFITDPVALSPNNTVADVWDIKDRFGFCGIPITETGKLNSKLVGIVTARDIQFRPNSAKLSTVMTTGDELVVAKSGVTLEQANTILRDSKKGKLPIVDTEGRLVALLARSDLLKNKDYPLASKKPESKQLICAAAIGTRGPDRERLRLLVEAGLDIVVLDSSQGNSSYQIEIIRWIKGEFPDLEVVAGNVVTREQAAALIDAGADGLRVGMGSGSICITQEVTAVGRPQGTAVFAVAEFARKFGVPVIADGGISNVGHIAKALALGASAVMMGGLLAGTTESPGEFFYNEGKRLKKYRGMGSIDAMDAGTVKDKRAQATADIDNAATSRYFSEGDVVRVAQGVAGAVQDKGSLRKFIPYLHAGLQHSLQDMGTRSIAEMQDRAYSGELRFELRTASAQVEGGVHGLHSFEKRLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MEW2</accession>
    <name>A0A2X0MEW2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C038g11719 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C038g11719</name>
        <name evidence="6" type="ORF">BQ5605_C038G11719</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000061">
        <property type="protein sequence ID" value="SGY92154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MEW2"/>
    <dbReference type="STRING" id="796604.A0A2X0MEW2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01862">
        <property type="entry name" value="Rab7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000086">
        <property type="entry name" value="Ras-related small GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF20">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB-7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY92154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="207" mass="23229" checksum="CB67337F10C8E70B" modified="2018-09-12" version="1">MASRRKVLLKVIILGDSGVGKTSLMNQYVNKRFSNQYKATIGADFLTKEVMIDDRLVTMQLWDTAGQERFQSLGVAFYRGADCCVLVYDVNSSKSFETLDSWRDEFLIQASPRDPENFPFVVIGNKIDVEEGKRMVSQKRAMTWCQSKGNIPYFETSAKEAINVEQAFQAACKNALSQESEADLYSDYPDAIKINAHDADKSNGCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MFQ3</accession>
    <name>A0A2X0MFQ3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C014g07617 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C014g07617</name>
        <name evidence="2" type="ORF">BQ5605_C014G07617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY19325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MFQ3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY19325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="170" mass="18900" checksum="48C911BB3A0DA2E5" modified="2018-09-12" version="1">MCCLSCLLPATRQRLPLPPAGEVGTAVWYVLQRRQILVKELHESRPTAFGLIGGVFAGRAKQVLRRSRGSPRHFGRRLSTLNNTQIKSLVTESSRRSSGPSAVDVRHTTIDLDAFRRELGLTPDPAAEHAERDRDDVYERRVEEVLGSRSEHEVEEEDDAELGEGDGESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MGZ5</accession>
    <name>A0A2X0MGZ5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C008g05350 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C008g05350</name>
        <name evidence="3" type="ORF">BQ5605_C008G05350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY80294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MGZ5"/>
    <dbReference type="STRING" id="796604.A0A2X0MGZ5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015910151" evidence="2">
        <location>
            <begin position="23"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY80294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="287" mass="29818" checksum="FEAEBA302445FD39" modified="2018-09-12" version="1">MRSSTTILLVVLSTWAFIGIQALDVVYPTAPVVFDQSGAIENRIVWSLTPLTNPPPATNFFDIWMRNGIGEIYPDALNVLIASNLDMTNPNVTYVWPDAAKYVPGPGYQLFFTAPGNASLVYCDSKVFSIGSTTYDASHTTYTGPSVELQPSSTSPASATEPATETVTGSATSPAVMLTTTSSAAQVAETTTVTNTLSASPTPTTVIESSFITSMIPASAKTTATPPSASVVLANSKPSSSSRPVATDYAGPAGQGFNLFSSSGMSLNVRRAGMGSLVVAMTAFIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MH06</accession>
    <name>A0A2X0MH06_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Vacuolar fusion protein MON1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C016g08087</name>
        <name evidence="8" type="ORF">BQ5605_C016G08087</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
            <location evidence="3">Multivesicular body membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 3">Prevacuolar compartment membrane</location>
            <topology evidence="1 3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Vacuole membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MON1/SAND family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY20537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MH06"/>
    <dbReference type="STRING" id="796604.A0A2X0MH06"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043972">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043971">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043970">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004353">
        <property type="entry name" value="Mon1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027">
        <property type="entry name" value="SAND PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027:SF7">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN MON1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19036">
        <property type="entry name" value="Fuz_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19037">
        <property type="entry name" value="Fuz_longin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19038">
        <property type="entry name" value="Fuz_longin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01546">
        <property type="entry name" value="YEAST73DUF"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="FUZ/MON1/HPS1 first Longin" evidence="5">
        <location>
            <begin position="335"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 second Longin" evidence="6">
        <location>
            <begin position="501"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 third Longin" evidence="7">
        <location>
            <begin position="630"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="107"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="284"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="310"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY20537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="749" mass="83160" checksum="E59F17B4E4868F7D" modified="2018-09-12" version="1">MGPPPASPATPSDPGSSLSSLDRHATSTSTATLPRLMRGLTDSSPRRERTTIASASTWTSSNWVEAITSAESGKDANSRRKLRKVKSSFLTTTAPTTTTATATTALGDIIPSIHVDQGPRPEKEEEDGCQEGDSDSSGLANILSRVKGMSPKPRTKREPDGLTPHAMPSRHRRIVSAPVHRTGAHSADDTSDDEEGQNAHDDSDTGGLGVPTQQTIQAARLAAENSRRSEEEQRLAVADDDDDGSQQDGNRSDIEDDVLHSNNSGFSDKDDDDEEEQLVTRAQGHTDPREMLRAQLRRNETGPSTTVRRNRSEHAESDKGRPSTEQEAIELTPRRYFILSSAGKLIFTTDLDDEEATGYVGVMQAIISIFADEGDKLRYVDAGKMKIAFVLKAPLYLVCVSDWGEPESVLRTHLEYLYLQVLSIVTYSQLSGIFSKRSNFDLRRLMQGTEPFFHHLVKTLQTSFAILTSSLEVYRIDQGTREEVAKALLPSKHKPQAQSLGLLYAFVISSGRIVTLLRPTRHTIHPTDLHLLLSTISSSTTFQAPDSESWIPVCLPRFNNKGFLHAYISYLTQDTGIVLVSAERDGFEGVKAWGEEVKRTLKAKKLLDKIEEPKVQRLQEYSLMDLAVPGLRHFLYKARAYVQITNPVWEGEYETSRNRVRLITLYQRLYEALHVRPAYAGGVHRPPAKLMYLRTEYEAVLGWTTSSFELYLAVSPLLPKTAVVSAARAVIKWIKAEENRLFLTSAPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHI7</accession>
    <name>A0A2X0MHI7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C008g05341 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C008g05341</name>
        <name evidence="2" type="ORF">BQ5605_C008G05341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY80261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHI7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY80261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="271" mass="30859" checksum="1567B9998CC89C46" modified="2018-09-12" version="1">MGSVLTSSATVQTQQHHISASSIAEDGRSTTLASRPTTSNSSNSMSHRIEEVQDEIRALHDAVRALPSTLRLSSSQKETHVLYNLQCRLEKVNDRNDWNDFKTSRFFRCLLEKNGLEGKCSVCLPASSRNYLLSLTRRYSDGQIDHSDPYKVPKNSSALQAIGSRYWEQVKNLPDLWEQWKEARASEARDRKETARPLKRWRIDSATISKLRRRYENATTELVREDSALRFRLLRGQVPPADLRSSAPDQYAEGYGFDALVIVSSNKLENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIF3</accession>
    <name>A0A2X0MIF3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C037g11582 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C037g11582</name>
        <name evidence="2" type="ORF">BQ5605_C037G11582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000062">
        <property type="protein sequence ID" value="SGY93299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIF3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY93299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="260" mass="29446" checksum="68DC282138055E02" modified="2018-09-12" version="1">MGPAGRVPHRHEQAHESVPSASLVRLEPEPLLGEGVQGMGRVVGHDFAVRVGRLPRSRVHRFLYVRRSYTEHHLAKAPLATGGGGPHAFLSFDVAVTHRTDMHLMRRDFIKLFNAKHSDLDPPLRSSDALAVRLLPFGGLRTFQPDRTDFIERRDRRIQPGYLTPEELQHLEKKGIRFGASDASVGFQHVMDTRTPSAPDPSDLLGLPSLIDQSISGTFVWPEERVVFPKRPLKQVTLEPDEDDEQWWVRAIGVRRLRDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIV1</accession>
    <name>A0A2X0MIV1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C038g11673 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C038g11673</name>
        <name evidence="1" type="ORF">BQ5605_C038G11673</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000061">
        <property type="protein sequence ID" value="SGY91496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIV1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY91496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="58" mass="6533" checksum="A7F2C056F51C1685" modified="2018-09-12" version="1">MPGTVGKFDVWIMEFKAIAQEIIDTKTTINDVLATLLLAIAHPIRSILLRQQCSYSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJK3</accession>
    <name>A0A2X0MJK3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">BQ5605_C033g11156 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BQ5605_C033g11156</name>
        <name evidence="16" type="ORF">BQ5605_C033G11156</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = thiamine phosphate + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:47848"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62890"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = thiamine phosphate + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:47844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>4-methyl-5-(2-phosphooxyethyl)-thiazole + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + H(+) = thiamine phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24212"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17957"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000066">
        <property type="protein sequence ID" value="SGZ01611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJK3"/>
    <dbReference type="STRING" id="796604.A0A2X0MJK3"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004417">
        <property type="term" value="F:hydroxyethylthiazole kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01170">
        <property type="entry name" value="THZ_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00228">
        <property type="entry name" value="Thz_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00097">
        <property type="entry name" value="TMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000417">
        <property type="entry name" value="Hyethyz_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034291">
        <property type="entry name" value="TMP_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006830">
        <property type="entry name" value="PRK09355.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00693">
        <property type="entry name" value="thiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20857:SF23">
        <property type="entry name" value="THIAMINE BIOSYNTHETIC BIFUNCTIONAL ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20857">
        <property type="entry name" value="THIAMINE-PHOSPHATE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02110">
        <property type="entry name" value="HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01099">
        <property type="entry name" value="HYETHTZKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="Thiamin phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamine phosphate synthase/TenI" evidence="15">
        <location>
            <begin position="37"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SGZ01611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="537" mass="57231" checksum="C84E570C89D9F8DD" modified="2018-09-12" version="1">MVKPAIDYSLYYVTGRELLPPSSNPNDVDLNPTPYYLTHLESALKGGVTVVQIREKDVGGREFYQVAKRSKEVCDKYSVPLIINDRLDIALLLSCGLHVGQSDLPAPQARQLLGPDQLLGVSINTVEELDTVLAYPEGTVDYIGVGPCYGTKTKKDLSPVLGVRGVRDLLASLGGSEIKVVVIGGVTPETIPNILYQTPAAMPGSNKYRHLDGLAVVSSIAASPEPDQAARSLLSQFRTSPRFSLTLPTSLHSTPTLLDQVINLFTRLQSTSEEHRTLVHHLTNQVVMNDCANLTLALGCSPIMSVVPQELDQLAGYLGCLLLNLGTATLDQVSAQRQAGRAANRVGKLVVFDPVGCGATVHRKGMADQLMGDVRVSVCKGNAGEIGSLLGSKEVKARGVDSVGKGFADPASVVRDLARREKFTVAMSGEVDYISDGEVVVKLSNGHDYQGIITGSGCMASTAVACFASLPLEKDETIASRAFLAAVTGITAINVAAEIAAKRKDVMGPNTFRAAMIDECWSLTADKLRQGAKFQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MK82</accession>
    <name>A0A2X0MK82_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C035g11434 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C035g11434</name>
        <name evidence="2" type="ORF">BQ5605_C035G11434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000064">
        <property type="protein sequence ID" value="SGY97973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MK82"/>
    <dbReference type="STRING" id="796604.A0A2X0MK82"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY97973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="436" mass="48182" checksum="1173AEFD8B4B360A" modified="2018-09-12" version="1">MVSRGYMRATADACLYIKHSGTSFAIITLYVDDGLIASNNQSFLDSELGSLHKAFQLKRLGPVSYFLGFKIHHTKDYILVHQSKYVRTMLEKFDFASPSKRRAVTPMDDRPLLRINATPFANVSLYQSAVGSLQYASTRCRPNIAIAVRAVAQKNSCPTVDNWAAVKRIFRYLNSTIDLGILYRNSSTTRLMVYSDALFADDPESRRSVGAYASMLAGGVISWQSKQQSMIATSTTEAEILSASSATREAILLRRLAGDVSIPQAQPTIIQEDNAACIQIAKDPVELEYCPTHVNAADIMTKPLGFQRFDQLCALLGMVSLVSLTGGSSCRGVPLSPCCNTRRESQSYASVRTVGYIYGDVNVARDAAVTNRGLFPFAWKRLNFTGSYNPRNAPKEDAKADTFTPYQFLLRAVRTTADPTDEASRESWLSPPFQFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-11-27" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLG8</accession>
    <name>A0A2X0MLG8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C028g10561</name>
        <name evidence="11" type="ORF">BQ5605_C028G10561</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 10">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Endoplasmic reticulum membrane</location>
            <topology evidence="2 10">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the OST1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000080">
        <property type="protein sequence ID" value="SGZ13304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MLG8"/>
    <dbReference type="STRING" id="796604.A0A2X0MLG8"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007676">
        <property type="entry name" value="Ribophorin_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049">
        <property type="entry name" value="RIBOPHORIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04597">
        <property type="entry name" value="Ribophorin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="533"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGZ13304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="559" mass="61053" checksum="4000DA72C3E09157" modified="2018-09-12" version="1">MRVVLSSRLPMWTSVGVLLSSTFASVVGLSSTYVSPSPFHASSIVSTVNVGGPLTTTFTSYTLNYQPSADSGSSDEKNSHWTVGVEGQPGFVEARIGRGPHKQKALLEVEEVKSSVGQDGARSTTFLPKNRQLFWKYIILATGGTQSAYGKHQHMCSGSSPKGLTFYAITVPKPTDESAQTVVTLETVTAHLNKPLEESRPQVTEGVRMQWSSDISHLLAGLDPADVTALESIKIKVVCPTPRISEVKAPPLFDESHPQGGATVTFTSKGAPSDIFVPSSGPQIASVVYQLSEAIPSVRKLERIVETSHWGAKASFQDNIDLYNPEPKLQGHFSRLEHQRLMMQNRAKANSITDLSIQLPAGANNAYYYDLVGNVSTSNFRPSPPLTLTQKSKGKAPAPALLELKPRYPLQGGWNYSFTIGFDVPLSDSVKALNRNDGKRMFLLAVPFVTPLKDVAMDDVTVEIRLPEGASDIKVTPPFPVDSLTIDALSKGYLDSTGRPTVRLYKRSCSDRHSSPIFVEYSLPLYREFLQKPLSVAMVMLTVFVLTLIARRTEWAIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MM33</accession>
    <name>A0A2X0MM33_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">BQ5605_C025g09969 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C025g09969</name>
        <name evidence="13" type="ORF">BQ5605_C025G09969</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000087">
        <property type="protein sequence ID" value="SGZ26830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MM33"/>
    <dbReference type="STRING" id="796604.A0A2X0MM33"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3370.10:FF:000002">
        <property type="entry name" value="Transport Sec61 subunit alpha isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="entry name" value="SecY subunit domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019561">
        <property type="entry name" value="Translocon_Sec61/SecY_plug_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006341">
        <property type="entry name" value="PRK08568.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="SECY/SEC61-ALPHA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10559">
        <property type="entry name" value="Plug_translocon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="Preprotein translocase SecY subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="327"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="482"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Translocon Sec61/SecY plug" evidence="12">
        <location>
            <begin position="83"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGZ26830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="520" mass="56972" checksum="C1B6A1F748BFCECE" modified="2018-09-12" version="1">MSGFRFLNLVRPFLPILPEVTAPDRKCCSLDRALTYDYSVMRCNSTDPIQHQELTSTLLILLAGTDALVPTSPQVGWTAVTLLIFLVCSQIPLYGIVSSDSSDPLYWMRVILASNRGTLMELGITPIITSGMIIQLLQGAGFIEVDFTLKEDRALFAGAQKLLALLISFGTSTVYVLTGLYGQPSDLGAGVCLLLVVQLIVAALIVILLDELLQKGYGLGSGINLFIATNICESIVWKAFSPTTVNTGRGPEFEGALIALFHLLFTWNDKSRALKEAFYRERLPNVMNLIATVGVFALVIWLQGFRIEIPVKSNRFRGQRGTYPVKLFYTSNMPIMLESALTSNVFIVSQMLFNRFPENLAVRLLGVWEPMEDSAQLMAKSGLAYYMSPPHTLKEVVTDPIHTSLYIIFMLTACAIFSKTWIEISGSGPRDVAKQLKDQQMVIAGHREGSMYKELKRVIPTAAIFGGAVIGLLSVGTDLVGALGSGTGILLATTIIYSYFELMMKESGGPEMQAMAELMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MMX6</accession>
    <name>A0A2X0MMX6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g02147 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g02147</name>
        <name evidence="2" type="ORF">BQ5605_C003G02147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MMX6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF66">
        <property type="entry name" value="HOOK MOTIF PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY39115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="398" mass="44781" checksum="AD98ECABBBC09EA7" modified="2018-09-12" version="1">MAVCIHYKARHWECERSKSTRHFSACCSQGKYRQLREGSDSGQLLRPTTFVCTTWLIDPAEATDTRPGPDGTDSRIQRSTLTKLESILRTGNCFVREFASAKARAGWDTAKEWILRLCLPPSRDRRTHNLPTSSTEMAMLICDSDTNTGDRGPQDLILQVHGDRCPDGRLKYQVVSSLHQSAIPLRYPLLFPAGEDGFHPNIPLCGFHQAKPPIARNREQIDNGVQLRELLAGLGLDDEDEQEDEDRDNEDEDGEEGDEEDGDGERQVKRSRWRVSRSQFFAHYLPKATSTSQSRIAPNVPSWTIPGCDGVRCQTWKASAAHHDDVRLQLTGNQGCTGADTACNRPDLIARVFEAKSGNKRHEYKMNGFCFFAVLRIDLVIRCSLRQLVLSNVNLRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNY1</accession>
    <name>A0A2X0MNY1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g02477 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C003g02477</name>
        <name evidence="1" type="ORF">BQ5605_C003G02477</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY41157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MNY1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY41157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="206" mass="22629" checksum="9B92AD2B57894BF2" modified="2018-09-12" version="1">MTLLGLFQDAALSTTPPCPMRSFVISQIVPFAGQMVSKLTSTPVHFMRLLVNDRTMDLTHSCDQDNVSEKETLCETYGFLYGIEKLAKAGTQEFAKCGFVPADLWAKPKSKGAQVVAALVTLVLKFAFSSLALHCGPDFSASLPLSYRKSMFRARVGSAILSWSSPSIADTMGGFWDTDDTNYTHSLRKRTPGATLPVPPRWRRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPF7</accession>
    <name>A0A2X0MPF7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C023g09660 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C023g09660</name>
        <name evidence="7" type="ORF">BQ5605_C023G09660</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ23915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MPF7"/>
    <dbReference type="STRING" id="796604.A0A2X0MPF7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09252">
        <property type="entry name" value="AP-3_Mu3_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="6">
        <location>
            <begin position="227"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGZ23915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="497" mass="52598" checksum="3E3157CF80C05D73" modified="2018-09-12" version="1">MQGVAILAGSRRVLSTQFTTSPLRAALAINAALASTDSVVWVPNLNPGVSLRLSGRTRGDEAESDDDDDQVENSAEDDEGIEVQPWASTSKRQATMGRSVVCQIERNGLRYIAPISREVDPIIPLHFLHQLHEVLENYIGGAVTEASLKDHFDIVLALLEEMLTAERPQLTEAAQLRELVVPPSQLLAKVASTAANVAGLTVATQSSANALLASPLPWRRTGIKYSSNEIYFDVTEALDFVLDKSGKIVSGGITGNVACRSRLSGMPDLVLSFTDPSHIEDAAFHPSVRYGRWTKDKVVSFVPPDGVISLMTFRVGSPVPKSSLTSSAASSLAILPIQITSSVTHGSQGGAFTISLTSHAAANRPLTRLVVRVPLGKGANGLTANVTGGPFHRDSNGNIEGGGAGRWDVVNLPNGEGSVLVWTVDELAATDRAAVLQGQYMSPSESRGASAFTVEFTSAEAGFSGLRIAGLKVTGETYSVYKGVKVGGRGKIEVRCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQ14</accession>
    <name>A0A2X0MQ14_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein eS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C016g08079</name>
        <name evidence="6" type="synonym">RPS1</name>
        <name evidence="8" type="ORF">BQ5605_C016G08079</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the eukaryotic ribosomal protein eS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY20508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQ14"/>
    <dbReference type="STRING" id="796604.A0A2X0MQ14"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03122">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001593">
        <property type="entry name" value="Ribosomal_eS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018281">
        <property type="entry name" value="Ribosomal_eS1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027500">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11830">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01015">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01397">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01191">
        <property type="entry name" value="RIBOSOMAL_S3AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="modified residue" description="N-acetylalanine; partial" evidence="6">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY20508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="325" mass="36692" checksum="C073F8E60D37AA3B" modified="2018-09-12" version="1">MVAMGQWVVVVVGVFVPPPFAPPLPRLAWPSSSSQSRFEDASAPAHSRQFNNPTPTFTLALSRAIHRWAHVHGGHLTNHGKKGIKKRVVDPFTRKDWYDIKAPSIFDTRNAGKTLVNRSSGLKNANDSLKGRIIELSLADLNKDDENTFRKIKLRIDEVQGKNCLTNFHGMDFTSDKLRSLVRKWQTLIEAHVDIKTTDGYLVRLFSIAFTKKRPNQVKKTTYAKSSQVREIRKKMFEIMGREASSCDLKQLVHKLVPEVIGREIEKVSQGIYPIQNCYIRKVKILKTPRFDLSKLLELHGGDVAEDVGASVKKDTVEIPVLTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQU1</accession>
    <name>A0A2X0MQU1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C026g10144 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="26">BQ5605_C026g10148 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C026g10144</name>
        <name evidence="26" type="synonym">BQ5605_C026g10148</name>
        <name evidence="25" type="ORF">BQ5605_C026G10144</name>
        <name evidence="26" type="ORF">BQ5605_C026G10148</name>
    </gene>
    <organism evidence="25 27">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 27" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ27618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ27630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="510"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="257"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="785"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="267"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGZ27618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="SGZ27630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1403" mass="156004" checksum="1DE32DA36B29A59A" modified="2018-09-12" version="1">MSPSETIAQESGEIKIAKLGKDNYELWSIRVEAYLESKGYASVLEHGHVRPSDVSLAEWRTMHGLDASVTDTQVVVNLQKKDRSARALIIQCIDDANLKMVKSKTLSAKDIWDKLRQHHEGNAKPFKIRTLLMELSNAKYDEDENMGEFLKSMIDKADQLDDLGQKFGDEAMIAYILQALPPSYEMLKQAIRLGENRSVDHVINRLTDEYTERKLSGKFDKLLKNAGALAVQSTQASRDPNCVCRGCKGKGHFAMDPECPKYDAKKNHGRARNRNKKKKQDSKESADSNELAEFVLTVKSLDESHSLQDNVANRVSQLNQGEIWILDTGASQHYVGDASLLSNRQSGNLKVQTASGQVVHCDTYGMVRFKLKSGASLSLANVYHLPGAPVNLISTRALFKSGAKCGWEDGKDVMTITYQGVILAKTLSGTGYALDFTRIVEDQAHVATRATVGAPLMEWHRRYGHVPVSSIMELVKSGAVEGLVLTDEKVHDCEPCISSKSRASKFSELATQVTDVLQRVFMDIGFVAEDQVDFQGRKAYLAIVDQYSTAKWTFPLKTKSAEEVTRVWIAFRQGVEKMTGRKIKRVRTDNGTEFTNKLIGANFQSQGILHETSAPYTPQQNGTVERFNGSLMAIVRAVLAASKLSWKYWSYALAYATFVANRILHAKLEGKTAYEVFYGKKPKVSHFRPFGSTVYAQVPKSKRSKLESTSVKGIFIGYDSEYNYRVLVDPGSDHKVIVTRDISVLEHKSEQVGVPEVTTLPVGPDEEKGPVDNDEIVVDELQDQVDGEQMPPARQNRPRWEYGDPAVKGRNPGRYEEIDANNEIPHRTRSQRRDAEQQVMYGSAMSVSLPPVPSNYEEAMASPEADKWIAAIKAELDAMARHQVLIDSDLPSGARALGSKWVFTRKENAQGEVTRYKARLVAQGFAQRPGIDYNETFAPVARPSTMLSLVGTAAAQGLFLEQFDFDSAFLNGTMTEMVYMKYPKGWDRPQTGQALRLVKSMYGTKQAPREWNAAVNSLMVERGYKRSDADSCLYVKRVDEKFIYITLYVDDGMVASNDQEFLDSEIEAFNKVYKLKRLGPVKLFLGLEFERTSDYIFVHQSKYIRDLVAMYGGGSVSKHPVKVPMEPRSDVEHSTDPFDDVALYQSAVGALQYAAHRARPDIVTSVRAAASKVSAPTQADWIAVKRIIRYLQGTVDWGLKFNHGGSTVFELYSDASWGDDMSTGKSIGAFVSILAGAAISWQSKQQSMVATSTTEAEILAASAAAKEAMWLRRLAADLELEQPKATLIWEDNQAVIAIALNPAHHGRTKHYNVHHFYIRERVTAGDIRIKYCKTGAMTADILTKPLARNLFELHREGMGMVGAGARVLCGGPAEAAGCLHEIASFWPSCFSLFSTTHSISHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MRL1</accession>
    <name>A0A2X0MRL1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C026g10245 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C026g10245</name>
        <name evidence="4" type="ORF">BQ5605_C026G10245</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ28000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MRL1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635:SF196">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="465"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="934"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="893"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="410"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="897"/>
            <end position="914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ28000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1572" mass="172113" checksum="E1691BC419F0C8FD" modified="2018-09-12" version="1">MDNNNNTNNASQAAIPPLRPDPPDPPGQAPATTTKSYSAAVGARFAAKHGNATANASTAVAAHPLMHNIENCVIINTPPSTSVEQVLLALDKYYPGLTGAMPCVIKGQRGLRFPKAADLDTLVANGLTFGKTLCKVEKLYSSTRGGVVQCTLTGFFSDPEGLCLFDEQIAAYGTVLRRRIQYIGKTKHISGVYDFILALKDVDVLPPASLSIARDGVTERIPLRITGGMRHCVFCRSAAHVRKDCPVAPACKSCASTSHATQHCSARHASSPQGPPTSRAPQASTVTTAAPAAVSKSISPASAHDRTTKKRRVEQDLAAQTEDLSNRAQPDSLSKNARPEFSFNFPCKTATPPAPQPASNQGIAYSLVEKSSESPSSETTSPSPSPPPATPKSIMTRSKSIAALSKPATREAPPTAPAFEASEPSPEPSSPTPLPSAAPKARPDDADTDDEADEEAEDQEAPPKDSTNEDRKRASLFSNLRSHNADVFLLSETGRPSPERVAQWTQECQDLKLSALFTPFNNTAILWKSDSVVITFDPESPPNTLRASFSFPDRVTDATFCVGDSKVRVVSIYAPSSDKPDKKRFLSHLSTALRQVVRDEPSPPALLVGGDWNCVESQPLDSENQNGTNNGGQEMRDLATANNLFDAYRLHHPKGRATTNRSAPGTCRRLDRIYVSPDWVDLFHDHKIWAPVLKSTHSMVVARFQVPGAIDIGPGKFKLGLHVIEGDATCEYLTSIVRTLYNKALLQTPNDPPAAWTSTKHRLLPELQALARTFARFRRGGSEQERADHSRYGAALRSRLDPSLAGPSSIFIRLRKVRASDLIPSLTVNDVVHSDPDSMLGAASDYFERVYEDRPIDDAALKAIIDGLASTRLSPADSLKLEEAYPLEEMTKAQAACKSNSSPGPDGLPTSSTIPAEARQPGPLPRNTAHIHLIHKRGERDQLSNKRPISLINADERIISQAHNQRLAPLLESLIGPTQRGFVPNRWIGTNIAEVQCLMDPGLPGSTPVSGMLAVMDFEKAYDRLSHPYLDAVLCAVGLGPKARQWYRATYTNQSASIFLNGWLSATFDILSGVRQGDPLAPSLFVLAIEGFACQIRLRVKGIDIAGLQNVRELLFADDACCALHNLSDLDHLNRAIEFYERASASKLSNVKSFLYPLGAFRDRSIAPDLGTWRLSDSQFRYLGIQVGVEIAEDAGWEDVKASTIARIRSIPMYDLPYAANRFLPAPKSVVKEIEEAAMLAIHGRASDGTQRRPKVSRSRLCTPLDHGGFGLIDLPRRLAIDHAKWVFQLRAPDGCFTRHLFDIRIRLQAPNEPTPFTLKTTKLLPARWVRDFEAWALVTTLNPPELSKSQNLEQWATHLLYFPAGHGIQLSVNPTLFRGPDGVMTPSSFVNASKRHQVFIFPLIFPKGHQKVFDLPEQRWNAWWKALRKVRRVHSDAEDTGHLLSLGSLHPGSQVASPTSPHPNNRSTSCVMCLSDAPECLVHLAVGCPFARRLWSALSPTPHPVFVDSVCPVVSRSERRLVELRVLFFHSIWKLCRRRQFSSDLLEPITETEFEGLRASIQESKGRLVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MSE9</accession>
    <name>A0A2X0MSE9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C006g03838 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C006g03838</name>
        <name evidence="3" type="ORF">BQ5605_C006G03838</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY54089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MSE9"/>
    <dbReference type="STRING" id="796604.A0A2X0MSE9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016002911" evidence="1">
        <location>
            <begin position="29"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Helitron helicase-like" evidence="2">
        <location>
            <begin position="161"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY54089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="591" mass="66295" checksum="5E202A6559DCA2A3" modified="2018-09-12" version="1">MTKPLGFQSFDQLCALLGMVSLVSLTGGSSCPCCNRMVRLFALVKIYGMAREGRSLVSGQYPRVNARLVSLYWIAFLSAPTAQQPALEIQPREDIRRCRGDDQNAIATEAAWRVRDENSVLQRTIDNSNANPQTGTAGSKCVTQSQFKVYYFHICPHNISYPTLFLEGRLFQKFVADAWALTEQERMRTNQKKLRAEEYLSLQASLAEGLDPAQIGKRVILPSSHTGSPRQMVQLYQDAMAIVCVFGAPDIFITMTCNPAWSEIVNTLLPGQTASDRPDIVARVFHGKLKALLADVLGVGRAPGVFGKPQSFPQVIAYVYVVKFQKRGLPHAQILLIIDAEDKPKTNDDYNKIVTAEIPDRNKFPALFETITNSMLHRRCDRPGKHTCHDDHGNCTKRFPKRLQPHTTSEDGGYPHYRCCAIHQYVKFPGTAQEEVYTDANIVPTNPFLASKYNCHVNVEIASGVAAIKYLYKYIYKGHDATSFTINEPGAQDKITDFLDAQYVCTPEAIHRIFRFGMHDRDPAVARLALHLPYEQQVRFVPDHGAPDLSTPLETTLIAFIKLCAKTPPKHNAQDLLYVDVPTQFAWNKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MSV3</accession>
    <name>A0A2X0MSV3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g04008 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g04008</name>
        <name evidence="1" type="ORF">BQ5605_C006G04008</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY55351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MSV3"/>
    <dbReference type="STRING" id="796604.A0A2X0MSV3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY55351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="348" mass="38246" checksum="129A70CF9912BC53" modified="2018-09-12" version="1">MYQHSVVSAAPACGVGVPIRSHVQALWSPGRAIATSPSLGREGSAVPWACSSARCWAPRGSTLFFVPHRSTESAPRAVVSAMANSTLGSPHHHLRKGECTAVCTHCKARHWECERSKSTRHFSACCSQGKVQPCSCLPLPSPISSIGSFFKARIAVSCSVQQQAVAFRENARSYNNALSFTSLAAHWDQTQVGTLGPPVFRVLCSNMADRPGRGHRHSTWTRRRRQSHATIYFDKLESILRTGNRFVREFASAKARAGWDTAKEWILRLCLRPGRDRRTHNLPTSSTEMAMLICDSDTKTGDRGLVSSLHPSAMPLRYPLPFPAGEDGFHPNIPLCGFHQARPPIARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MTC3</accession>
    <name>A0A2X0MTC3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g04178 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g04178</name>
        <name evidence="1" type="ORF">BQ5605_C006G04178</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY56831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MTC3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY56831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="343" mass="37765" checksum="FAF72F4EB5B17DCD" modified="2018-09-12" version="1">MTLLPRRPVLLLPLPKSHLQAFTSRLLYNNLHGEQRGSRDVGSCSRSSAQMSRKLLRRRLLRLSPSCSSHLAHRTSSHRHLELATSEAVVVEALQQIRDQEMAAACNIATNSKANGLLPSRNSLQHVLFECQPSSCFFTVSCGRIDFVRLRIRRVIGPLNILNGSVRWSDRRVGRKSEAMPSRYSTARFGGVTVVLAGDPKQCLPVILNGSVRWGDHPVGRGSEAMPSRYSTARFGGVTVVLAVPSRYSQLIACTNCLELATPEGVVVEALPRIRDKFYQEMSAACSIDPVADPQHLGSVEWTTARILLVARRLGGLKVSNDIVNRKSLSSSVPVARGARRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MTV7</accession>
    <name>A0A2X0MTV7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">BQ5605_C041g11988</name>
        <name evidence="21" type="ORF">BQ5605_C041G11988</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="FQNC01000119">
        <property type="protein sequence ID" value="SGZ33739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032549">
        <property type="entry name" value="DUF4939"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16297">
        <property type="entry name" value="DUF4939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0229">DNA integration</keyword>
    <keyword evidence="16" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="20">
        <location>
            <begin position="1179"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="19">
        <location>
            <begin position="1480"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="285"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1011"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="315"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1015"/>
            <end position="1028"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="SGZ33739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1622" mass="184005" checksum="912919DD0FD872D9" modified="2018-09-12" version="1">MEDLTQASLDSLIDQLRTLQARNQALEAECRSHLSDKENYQITVIALANQQQTLSDFAKAVVDQQKESIDVIKSGLANLNVTAPANTTITPVKSQLAKPDKYDGKKKVKFKTFITQIKFYIFGNPSSFPTDESKIAFIISHLTGDAFQHFEHAINAKDDSKPEWLTNYQKFLDQAELVLGDPDYRNNLTRQLMSLVQSGPASVYASKFTQISSQLDWNQAALIAHFHKGLKLDLQAQLELHDDPQDLQSLIELAIKVDNKLHLARHRTNASTQFRQTNWQYSHSVNSPLRTSPVSQLQANASTANTSGPAPMDLDATRSRRGPLSEEEKLRRRTNRLCMWCASDQHLRAQCPTAPPMIPRHTALNASPRMSCTGTLFPQVSSPPSPRYSQQNSTRFPKTTLFCPSYSISSPHPDLATSFVHDNRLQLIPHPTPIPLYVIDGRPIQSGNITHFVHLEVQFNGHTQSLRADVTQLGTYPLVLGMPWLRLHNPIIDWKRNTLVYSCQSCALGHTQPINVSIEGAPLVPLDHKHLDISFASSFAFERLVNNSDNHHGLLFYDPASHQLSSSIPAPSQSLSDDNQDSLEYLESLKNLVPPEYHHLLAAFSKVKADQLPPHRKFDLSIDLEDNTTPPFGPLYPLSETELQTLSSWLKENLSKNFIRASTSPAGAPVLFVRKKDGSLRLCVDYRGLNKITRKNRYPLPLIPEALDRIRGAKIYTKLDLRSGYNLVRIKEGDEWKTAFRTRYGHFECLVMPFGLTNAPAAFQHELYLPRSSRRLRALLQRLINNKLYCNPKKCEFNRASTEYLGFIISPSGVSMSQDKVKAITSWPTPTSLKELQQFLGFCNFYRRFIEGYSRVIAPLTRLLKKNTPFLLDSAALSSLDRLKQIFTSGAILCHFNPLLPSIIETDASDFAISGILSQVTDGHLRPVAFMSRKMLPAEQNYEIHDKELLAIVECIKIWRHYLEGSQHPFKIYTDHAALQYFQTKRVLTRRQARWSETVNHHKYTIEYRSGSKNNKADTLSRRPDFSEGGKASEQPGQILLRPHTLAASLVKFSPPSDIADLIKFHLSQDPVSNQIVNGLNHDSTLHPYFKLQDNLLLHHDKIYIPNAEPLKVKLLAQAHDSLLSGHPGQVKTFELLDRNYTWPGMRQFVNNYVKTCDSCQRNKPTHHRKHGHLQPLPIPSKPWSSLSMDHIVDLPPSSGFDCVLVVVDRLTKEAHFIPTHKTDSSRDLARTFLTHVFKLHGLPTDIVSDRGATFTSNWWSEFLAMLKIKPNLSTAFHPESDGQTERTNQTLEHYLRHFCDYLQTNWSELLPLAEFAYNNSFHSSIGASLIYVTRGYHPRLEVSLRDSFVTDVPKYLQHLRSVQETARKQILQAQETQARFANLKRKPSPPFKIGDQVLLNRKNIQTSRPSSKLDSHKLGPFRIQRIISPAAFKLELPASMKIHPVFHVSLLEPYQANSLASRCSNPPPPPEIINGEEGYQVKQILDSRNNRRSRRLEYFVDWTGYGPQDRQWVSAADFDYDDSLVIEFHTRHPHKPGFERIQGLNGARASSYLYDLAPRSLPLASTCFHEFLSLSLGFPSTINRASYSYKNNYINPASRPVILAIACCLRLSNLNPDSWGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MUF2</accession>
    <name>A0A2X0MUF2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C075g12926 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C075g12926</name>
        <name evidence="3" type="ORF">BQ5605_C075G12926</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000128">
        <property type="protein sequence ID" value="SGZ34837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MUF2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="2">
        <location>
            <begin position="432"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ34837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="633" mass="70367" checksum="5CCD53A4B0F04D20" modified="2018-09-12" version="1">MYQHTVVSAAPACGVHVPIRSHVQALWSPERAIATSSSLGREASSSSRSDQQNQPPRVMTTMQPILALRHVYEPAVQLCRTDSVVSAMANSTLGSPHHHLLRKGECAGLETRSNPSSPTHFSACCSQGKVRLPPPPQPNLEYRQLLQGSDSEAKAFRENARSYNNALSFTSLAALWDQTQVGTLGPPVFRVFGRLYHRLGALIPAVNQCPTFAQTWLINPAEATDTRLEPDGADIHMQRSTLTKLESMLRTKNHFVREFASAKPRAGWDTAKEWILRLCLPPDRDRRTHNPPTSSTGMAMLICDSDTNTGDSGPQDLILQVHGDRCPDGRPKYQIVSSLHPSAMPLRYPLLFPAGEDGFHPNIPLCGFHQAGPPIARNREQIDNGVQLRELLDGLGPDEEDEEEDDEDEGDEEDEENGDGERGSTRVSRSQYFAYHLHERDDYISIPHATQRLFLEFVIDGYSQVETDRLNYIRLHQESLRLTTAQGITDAVANGLTPDQIGRSVILGSTFKNSPREITQRYQDAMACVVKYGKPSLFITVTCNPEWPEIKAALGPNDKACNRPDLIARVFEAKLNRLCDDVFGNKQRAGCFGVVLTHTHVIEYQKRGLPHAHILITLAPDDHPLSTEAIDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MUV6</accession>
    <name>A0A2X0MUV6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C007g04689 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C007g04689</name>
        <name evidence="3" type="ORF">BQ5605_C007G04689</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY62434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MUV6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY62434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="249" mass="27155" checksum="712D4CE9927136F5" modified="2018-09-12" version="1">MSPRPHALQSLLLVTVAAPLFVFQVGAGATGRLSLMKFILPTVVGCFIVVMLVVKGYFFMQRNPGAVRDLFLPRAGLKVRWLGINIAPIAERPPSGPPPRYSRGLLSVFRDRRQGHDTNGAEIEEGGRRAGSRDEDDVSDGESRPAAQEEKDGLPSYAIDIELPGYGHVLRSDARQADATVLLGSSDISVQSDQNGASTVTEERFAGSADYERASRNNPVMTPEPVVLRDMAQLRRQTVLQSQVGSMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MVU0</accession>
    <name>A0A2X0MVU0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C003g02299 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C003g02299</name>
        <name evidence="3" type="ORF">BQ5605_C003G02299</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MVU0"/>
    <dbReference type="STRING" id="796604.A0A2X0MVU0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460:SF0">
        <property type="entry name" value="CID DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="273"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="756"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="601"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="625"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="661"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="758"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY39946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="784" mass="86000" checksum="020072093A525596" modified="2018-09-12" version="1">MPVHEGSSTSTAGSARTRALSPSPQVPGNSSHQHTSISVVSAASTSTIHQTRDMGRLCMQDQDEEVDVKPLIVVQDGDASKPQPGFSSESGSIGPLFGRLAVAFVRLASPSSSSSALDWIWHSMPPTDHRDNQTHLISVHGPTAASHPTSSKRRRSSSHSVSTSALNLLQQALLHHQQQSDMRVDNDDDDDDDHHHHLDGDDERAHGDLAGDPSAAAARKPSSHLLAPRATSSPSRAVSVTSEVDSLASSSNDALQTPPTKKLRKGARLGRLGPILDKIPIELLADVLAYLPPVMLLRLARTAKVFRSLLMSKHHSRAIWRRAFKRDGLGPFAVEDMSEPQIAALIWDKECLACGRTKVHKIVYIFEGRYCDPCLKQKVRTRSQIQSAHPCLHPNAFECAPFSTAPPCRGGNWPALPGQYMAGEYWLEETVLKRSEELHTHEREDQERCDGGGRVAKRVAYWKERLPLIERDAQMLQRWQAELDSSRSSDKRSLRMERTKVIRQRCLDAGYDARDVDIAVRADSAVYAHINQPYPLTDRVWRKIERPILSHVAALREQRLSDETRQILFDRFREEAARAQEAAAERHSQELQELRERDRSAQATVAATLAAHAQRTAASGSPAVGGSTSSFGTGIGQSPQRPVGNGMPPSSLTSAWNPSLAHQQQQQQQQHQQPYQAHAQYLNALRYGSAHGPRSTSAPSASPLYPSMGSYQRPAAANTLMNPAVVRQPVLVPNLTRITPSGSNALDHSLGAWWLGTSPRSNPARQSTSLPSRTHLPTPSSTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MZU5</accession>
    <name>A0A2X0MZU5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BQ5605_C008g05345 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C008g05345</name>
        <name evidence="11" type="ORF">BQ5605_C008G05345</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the COPE family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY80274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MZU5"/>
    <dbReference type="STRING" id="796604.A0A2X0MZU5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006822">
        <property type="entry name" value="Coatomer_esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805:SF0">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04733">
        <property type="entry name" value="Coatomer_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY80274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="317" mass="34353" checksum="E843CDAFD5D2F121" modified="2018-09-12" version="1">MDTISDADYYVVSLFQNGSYRSALSAYSELPSASTLPTFYAARAHLALSPPSPSSALSLLSSLGRSLDTRALTALANFLSGDHEGAIEELEEVQIELGERGLEDGEEGRFVRAVLGTVWWLSGDEGRREEAVEILNEAVQLGADQECLGILTHIYQSLSLPQRSLALLTSPQTTSFTSDSLQSQLFTARTNLSLGPKQRYEQAYYVYEEIKGLHGGRGESTLAGVAVSQACLGRWDEAVQAILEGLEMNPSHPTLLANFIALARYYIPNTQDTEALTAEKALASLQALEPTHPFVVELENKSDAFDEAAGKFGKASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N123</accession>
    <name>A0A2X0N123_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C009g05786 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C009g05786</name>
        <name evidence="3" type="ORF">BQ5605_C009G05786</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY85887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N123"/>
    <dbReference type="STRING" id="796604.A0A2X0N123"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012098">
        <property type="entry name" value="SND3_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112:SF1">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10032">
        <property type="entry name" value="Pho88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY85887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="186" mass="20595" checksum="17D2D95333868FE8" modified="2018-09-12" version="1">MNPAITNLLFSLGAMQVARKIDFEQKDTLQLVRIGYVASQLICLLAYYYTSLVIKRKNDLKVLKYVEPKAPMQQEPGAQVTTTNRDYDLSEVSKAVRSVLIGIAFMAFMHGYLKYTQPLFIQGIMGIKGLYESKILQLHILGRPATGDLKRPFEPAPSFLSPAAAKTEEAPVPATSAAAVEDKKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N390</accession>
    <name>A0A2X0N390_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C004g02924 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C004g02924</name>
        <name evidence="2" type="ORF">BQ5605_C004G02924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY68853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N390"/>
    <dbReference type="STRING" id="796604.A0A2X0N390"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057514">
        <property type="entry name" value="NTF2_SigF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35393">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35393:SF1">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24840">
        <property type="entry name" value="NTF2_SigF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SigF-like NTF2-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="SigF-like NTF2-like" evidence="1">
        <location>
            <begin position="118"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY68853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="211" mass="23329" checksum="AB27B74EEEE2DBB4" modified="2018-09-12" version="1">MENPASEIRNVVRKITEPRESAKILASVDRYFSDDSVIVHPMLNSPRAQGKHGVKAAYRMLRALTLNNKIEYHAVAFEDVTKSKGGETRACLIGEFGPTCGAHIEPLPPSLNYTSPSLDLTEHLQLRFLPVPEARNPVFHVRFLVRVDLRKGADNLWYITKQEDNIPTDPGSSGLLLIVPPINAMVNTVKWFAGMSTMGMAAVLNRLGVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N692</accession>
    <name>A0A2X0N692_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C008g05157</name>
        <name evidence="7" type="ORF">BQ5605_C008G05157</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N692"/>
    <dbReference type="STRING" id="796604.A0A2X0N692"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000009">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="47"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="217"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY79538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="440" mass="47912" checksum="2A319E482AE65493" modified="2018-09-12" version="1">MSEIDQVETASIASSDSSIADLNETPAGPKGTIASPAPGSAPRPRVYFDITINENEAGRIVFELFSDVVPKTAENFRALCTGEKGTGNSGKPLHYKHSTFHRIIKRFMCQGGDFTMGNGMGGESIYGEKFEDENFELKHDQPFLLSMANAGPGTNGSQFFITTVPTPHLDGKHVVFGKVIKGRSIVRLMENAPVKSDSPTEKIVIADCGQLAEGEDDGVKPDPHADGHEDYPSDDESDVGAVSSDTTLMIFWVITDDDLIAFQPNIVLKIATEIKTKGTELFQAGDFKAAQSKYLKALRYLDVHPVLPSRDYDLEQKFVALRLSLFLNSALTALKTSNPIKASDAQLAIDQATKALNLDGDADKQEMRTPLSDADKAKCLYRRALGKAAIKEEAGAVKDLEEARALVKGDKAIEAELEKTKLKIKAKKEAERKKFGKLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NBA2</accession>
    <name>A0A2X0NBA2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C028g10466 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C028g10466</name>
        <name evidence="8" type="ORF">BQ5605_C028G10466</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000080">
        <property type="protein sequence ID" value="SGZ11916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NBA2"/>
    <dbReference type="STRING" id="796604.A0A2X0NBA2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="44"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGZ11916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="488" mass="53632" checksum="194FB4D1414998CA" modified="2018-09-12" version="1">MTQMDGAYADEKAVVEHIDEIAELESSIDATAERKLVMKLDLWILPLVTLMFLLNFIDRSAVGNANVAGLSKDLKLVDYEYNISLMIFYVAYVLVEPFSNLALKKVGGMWLSALVVMFGVITIGSAFVKNYHEFLAVRVLLGLAEGGAIPGIAFVLGRFYRRHELVLRIGIFLALGPSLSGAFGGLLAGALIKQTIGSVKGWRCIFLVEGIITTAVGAMSFFLIPTSPETARFLNEAECALAVKRVAIEQLGAQKDKTNSKSLKHGLSNTLTWLCCLGYSFINIQVQGAALFLPTVIRTLGKFTPVEVQLRSVPPYVLATFWSIFISWLCQRTRKHGIWIAFTCCFSTIGYILFLTVHNNKVLYFATFITYSGAVPCGPVFLSWAVANASPETSRAITSALVPAVGTWGSIVATWAYLPKYAPRYKPGNSLNVAAAVMPALIALGITAYCKWENKQRDEGKRDHRLEGLTEAEQVALGFKHPEFRYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NCL0</accession>
    <name>A0A2X0NCL0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C020g09183 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C020g09183</name>
        <name evidence="2" type="ORF">BQ5605_C020G09183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000082">
        <property type="protein sequence ID" value="SGZ18415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NCL0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ18415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="449" mass="50073" checksum="D24A055D5EE46A1B" modified="2018-09-12" version="1">MDPGVILEKDFVIQSSSVRSSIGFVCKYCGSGRMRRSGAIKHAASRKHRVNVPRLGHEHEAASAPALAKYSFLDSTDEHEVDNTELGSEQGMWEQNTCPTPGRAIGSSGPPENDPGAILAAMGIPATPHVVQCAQVSGFVDYVETIYAATHVRFSGYRYSIRQALLEDPDIKERPGFLRYLISQARSSEVILEEMVKLKEEVAKLQEASVKLSVTDLKRKAAIAAKIFVATPFLLCHRNAAPIFAEALLRFGTVTRGVWDSDLEFQTEALSIFSTALATARSDLHKLGVERTHLYNQIGRVQRKEVDMLQALRVWYKDSGTTYTDEHLAWWSFLRLVEQTVVERGFEDTKRDFWLHLSGIATTVANKAAERFFRPRFCPNGTFDCSTFLYRAVVSQFYDADASPTTTQPKVSTTDSTFQAQCMAVITTCQPVADFQRLVLEAVQRKEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NM24</accession>
    <name>A0A2X0NM24_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cysteine synthase</fullName>
            <ecNumber evidence="4">2.5.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Cysteine synthase-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">BQ5605_C010g05861</name>
        <name evidence="19" type="ORF">BQ5605_C010G05861</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="4"/>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NM24"/>
    <dbReference type="STRING" id="796604.A0A2X0NM24"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000016">
        <property type="entry name" value="Cysteine synthase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000096">
        <property type="entry name" value="Related to cysteine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="18">
        <location>
            <begin position="155"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="18">
        <location>
            <begin position="368"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="106"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="309"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="309"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="341"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00078545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="SGY13433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="593" mass="63980" checksum="0BE111939ADE14C6" modified="2018-09-12" version="1">MRERRFSHPHTAIGELRAAEKGLGSHLLSTLHAQPPTTHPPSKLASAVLTASSVLSALLPSFLHPTRLGGRKSLVLGLTLGFSLSLSLTGLAIYAQDAWKRSMVKRGEAHRKARRGNGVREGGEEHGDQEDEDEDEGMSKNLVEIRGEDVVHGVEGLIGNTPLVRINSLSDALGVEILGKCEFLNPFGSVKDRVSLRNLMMLQPVIQQAENQGLIVPNTGSCIFEGTSGSTGISIAGIARARGYRAHIVLPDDVAAEKVQLLEALGAVVEKVRPVSIVDKRHYVNLARLRAQQFGQRVLHASTSSSEANFIVPSNNNSSEDLSLPSATTSSRTPPFEPSLLITSQPNPTAYNSSSAPSKTYIPPARGLFADQFENLSNLQAHSQGTATEIWKQTKGEVDAFVSGAGTGGTIAGVGRTLKGHKKGVKIVLADPQGSGLFHRVHDGVMYSTTEAEGTRRRYQVDTVVEGIGLNRLTKNFEKALPFIDDAFRVTDEEAITMSRHLAKQDGLFLGSSSAVNLVACVRLAQKWKKEGEHTKGKRRGGIEEGGKKMIVAILCDSGTRHYSRFWNDKVLQGLGYRTDLSIDTILELSTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NNS5</accession>
    <name>A0A2X0NNS5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C013g07253 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C013g07253</name>
        <name evidence="2" type="ORF">BQ5605_C013G07253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NNS5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY15122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="320" mass="34283" checksum="BC8AD545D7CED7C5" modified="2018-09-12" version="1">MHLSHEQHVKIPSYPAFANRLQSSACTRRSALSDPNRIPLQADIINQTWLQQKDHDGSSSISDPCHPWQHYPSPESITSDLPPLLAPGSTSVFGAPPHVAASSRSVSSVIEQGPASGADARDVKHSSLDGSTSPPPPPHKRTRTRSYSISSATSTVDTHRSVRSSSFGSSFSGTSTSTGLSTAKRRSSASSRAISKAYESRRYVAEALRAAIQSGRVNAATVSNDTVSRIVEGARKEAAKEGLAGKRTQGRSGVGQESGQPNEQAELRVRDKVKQVVRNAVSVEEDGEIEVNWDELSTLGQDGRKRRRANKTTTVVAVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NR38</accession>
    <name>A0A2X0NR38_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C015g08011 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C015g08011</name>
        <name evidence="3" type="ORF">BQ5605_C015G08011</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY18221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NR38"/>
    <dbReference type="STRING" id="796604.A0A2X0NR38"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016170495" evidence="2">
        <location>
            <begin position="27"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY18221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="185" mass="20237" checksum="C1A58565BC6906CC" modified="2018-09-12" version="1">MPLDFRLLLILAALGALYLLPSDVSADFTETSEGPGEESAGSESGSKSEMAARKAYTPTTFLPGQVIEPVYNSSLKVGKRFRYSYLPLYESTEYISVTLAVQHRREEARATAGEGFTNYTLTSSLARDASDTGSGGRLQSWFLVPQNALPSDDGTYFSFIETVELRSKSSHDDGLHNYSVEVKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NR93</accession>
    <name>A0A2X0NR93_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C011g06248 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C011g06248</name>
        <name evidence="2" type="ORF">BQ5605_C011G06248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY11718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NR93"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY11718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="160" mass="18194" checksum="C3A671A8897F6423" modified="2018-09-12" version="1">MTKTNRRTKTATMRMKTARKGTKRMVMANDEGQVKGSRWRVSRSPFFAHYLPNATSTSQFRMAPNVPSWKPTPHHDPRHQRLDPEPNRDITQRYQDAMACVVKEEKPPLLITMTYDPDSPEIKAALGPIKHATVRISLHECLKPSPATSDMQAVSAMNVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NT68</accession>
    <name>A0A2X0NT68_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C010g06025 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">BQ5605_C010g06035 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C010g06025</name>
        <name evidence="2" type="synonym">BQ5605_C010g06035</name>
        <name evidence="1" type="ORF">BQ5605_C010G06025</name>
        <name evidence="2" type="ORF">BQ5605_C010G06035</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NT68"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY14008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY14035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="254" mass="29655" checksum="480F567BC3C08E76" modified="2018-09-12" version="1">MLDRPVQPHCDSRRATGIPLRLLLDKRDHFLPGDMSRFFEETAIEPTARFYKEAEVIWQAVSEETWVELDNYVEEIRHRCNHIIIRLRQRASWNMFTSEARAAWRDSWQFCLREGQLHLMQPIHFLREKYISQFNAKHPELDPPLRQSDKLTHRLSGLPSFKGDYVAYLRREGFEPARCFGLFEDALAHVKRRGGIHFDDRPTPDFDVLVDGRAHALPKDRDILGLPAVLPPPRHLPVTGDGRWTPLTTLNTCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NTJ5</accession>
    <name>A0A2X0NTJ5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C019g08858 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C019g08858</name>
        <name evidence="1" type="ORF">BQ5605_C019G08858</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY22795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NTJ5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY22795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="56" mass="6655" checksum="55DEBD34DEF33C95" modified="2018-09-12" version="1">MPFLKNMRTLVDDTSLRTSWSTMWMLSLYKARGDRECTEEEEKMVLSISDSERSMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NUR9</accession>
    <name>A0A2X0NUR9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C012g06700 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C012g06700</name>
        <name evidence="1" type="ORF">BQ5605_C012G06700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY15912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NUR9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY15912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="63" mass="6748" checksum="E5A1F3B171A328A6" modified="2018-09-12" version="1">MPPPSHTQCATAVLMSHQASRALPIHDARRSQPGLVAIDSLAHQHSTMVDKFPLVSAVQHSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NVT1</accession>
    <name>A0A2X0NVT1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C002g01214 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C002g01214</name>
        <name evidence="4" type="ORF">BQ5605_C002G01214</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY31172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NVT1"/>
    <dbReference type="STRING" id="796604.A0A2X0NVT1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000015">
        <property type="entry name" value="Putative zinc metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000031">
        <property type="entry name" value="Putative zinc metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF16">
        <property type="entry name" value="METALLOPROTEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07610)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="2">
        <location>
            <begin position="96"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="3">
        <location>
            <begin position="234"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1061"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1072"/>
            <end position="1088"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY31172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1088" mass="119512" checksum="2FE55E17FBE6BBB8" modified="2018-09-12" version="1">MACSPPTVPHSLPNGTHGADRSNRTNALQGDFKLLVEHPLEFAQDVKVVKWISQSTGLKVVWCDVEGTPGKAVERLDGGPLVQGYFATITEIFDDTGRPHTLEHLIFMGSEQYPYKGILDTLANRSFAQGTNAWTDTSNTTYTVGTAGQQGFLSITPPFLDHILYPTMTDAAFVTEVHHLNPKGEDSGVVFSEMQGRENGSGDLMQLRLQRCLYDKLNALRSETGGLMEALRKLKVQDIREYHAGAYQPQNVTLIVVGRSLKPENLLSTLEREVLPTIVKHGQAQGPRPPGWRRPFVESTTAQNPPQIPAQGLTETVEFPEQDESVGEIMLSWIGVRANDFVHDLALEVLGEYLTDSPVSPLYKQFVEVDEPACTDISFYASTEDPTILTVYLSAVPAELLKTLDATFKAFLKTLCEGDVDMERMESVLKRQKLQLLESIETNAADMLSTNILADAIFGPEDGSELGKSMDTMAYYRQLEGWSSAQWIALLEKYYVNAPNVTIIGRPSAALADQLAKEEKQRVAATVKRLGPEGLAELGKKLETAQAENDRPIPSDIISNFKVPDVEGIDWIKVESARSAGVAKEVGPVSDNQVQKHVDQDGSKVPLFVQYDHINSNFIEVSIVLFITDIPSQDPKHLRSLLPIYLDSFFSLPVTQADGTMLDFEEVVRQLDAETLSYSIDLNSPLQEGVTLRVKVEKGKYATAVAWLGDLLCGSSFSVDRLKVSTTKAIQNLPSEKRDGYEVAYAAYRQLLNDEATSTNVALNLLNRDEALPELLVRLKAEPEKVVEEFEGLRQSLLNPRAMRVQVKGDILAIEDPAATWLKQYRTVEKFSHSELVPVKLSQHALSLLGREPSKKVVIFGLPSIESSFGFHLAKGPNDWNHADQPALTVARAILNAQEGFLWKSIRGAGLAYGASISQDTESGTISYRIYKSPDTYSAFVAAQELITSIVEKRVEIDALTIESAKSSLAFDTANKESTMNEAANAAFRNVLVGLEEGYGRVALARTKDVTLSDILRVIEKYIAPIFDPSKSIGAVSAHKAKIDEMATSFEKLGYEVEKRTFGDADDDEDGSSCGSEGSASGSESGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NVV3</accession>
    <name>A0A2X0NVV3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">DNA polymerase</fullName>
            <ecNumber evidence="20">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">BQ5605_C002g01244</name>
        <name evidence="26" type="ORF">BQ5605_C002G01244</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 20">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="19">Forms DNA polymerase zeta with REV7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="20"/>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY31587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0NVV3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05778">
        <property type="entry name" value="DNA_polB_zeta_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05534">
        <property type="entry name" value="POLBc_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000007">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000002">
        <property type="entry name" value="DNA polymerase zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056435">
        <property type="entry name" value="DPOD/Z_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030559">
        <property type="entry name" value="PolZ_Rev3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025687">
        <property type="entry name" value="Znf-C4pol"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812:SF1">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24055">
        <property type="entry name" value="POL3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14260">
        <property type="entry name" value="zf-C4pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 20" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 20" id="KW-0235">DNA replication</keyword>
    <keyword evidence="15 20" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12 20" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="13 20" id="KW-0408">Iron</keyword>
    <keyword evidence="14 20" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 20" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 20" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 20" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase delta/zeta catalytic subunit N-terminal" evidence="25">
        <location>
            <begin position="83"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="23">
        <location>
            <begin position="1082"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="22">
        <location>
            <begin position="1360"/>
            <end position="1831"/>
        </location>
    </feature>
    <feature type="domain" description="C4-type zinc-finger of DNA polymerase delta" evidence="24">
        <location>
            <begin position="1873"/>
            <end position="1946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="122"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="544"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="808"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="996"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1053"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="363"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="552"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="673"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="706"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="810"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00066055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF14260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF24055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="SGY31587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1964" mass="220834" checksum="22FD17805FA86026" modified="2018-09-12" version="1">MAAAHHATATAPTTPSPSTIIRFKLSDIDTVMSSDKTIYTNDQSPFVVDPHPGGPVPPMSTVPVIRIFGATDRGKRVMAHIHGAFPYVYIKYLGASLEPDAVNAYIKRLARALNLAMDYMTRDPQRGNRSNPNAKAGRHQSRPGQRGGAQSEPATPAVAFIVPCKGIPFYGYHVGHEAFLKIYITRPTFKIRLSETLRSGVIMKTKFDVFEDHAPFLLQFMLDCDLHGCGWVEVDECRFRKLPQHEWSPSDDLDPPSIDGPYHTRVYNSTSVPLSLIYPRYADDSPAPVSTCPIEIDVPIYGIHNRHKIKSREIQQDFIEFFQREELNGSEGGEQDKLVLSLRELWTDERRRREVVGEVGPGEVKDSTPRQWDKRGPTDPIWADEPRLRAKVDVLLQEDIKAYRAQPGFAQREPEWKTFVDEQQVAEKVQRGFMERLKTTFAQVDAVFLTRLEQDRRSNYEYGALIASRYDFANKNKSRTRSPSRPPSEDFDEKVFRAGSTQAQIERIVDEDEVAEMIYDQAVDEYSERAEVFNTQYFGDLKRRARQKDGSGDEAIEEEREKEDGEDNENGEAGVDVNDLFDGGTESDLMGPESSPQAPPPAQTSRADVNNGYLDSDVGSPADSVTSDFHDDGNRAQRQTYKVPIALDSMTPESLDETSAFEQTFKPMPTPARTPSVPFSTRSTSRSPTKQNLFRSPTKAVKVRRATSGASSASNSALGSDMDDEDDEHEPFLTFREHDTSMSDDDLLIPPVQQASGDDPSDMDGDLEEHASEILEEYVPTPTQVEAVQPSMVPVAMRSFIEVDEEVPISSHGSRGTIRSRGSSGRSASVSSLDAPPTTKRMTLRFDVSESESQSSFLASASNPPYTSELSIELEPISSATHSSGSRSAIHSPSLLLPLQNSNTSSTSSGRVIHTDHPVSARSWIYREPAPSAQQVLETLEMNNQPRVDYTNPYYSNPADVPRVANEYGGRRFVLRDQSMRNTPAFNHLDRRVRDAETTTRGTDDYPRMSKRSGDKGREQHALWEYVKRPPTRAEVKVRAKKEDLIQEAKSNVKPRTRGIEGPTQHQDGFKFTPVNGAPAQREKQHMAVLAMELHVNTREGLLPNPLLDPIQAIFYCLQSENDDVELNGRLPDTHVGCIAMWDAADSDLRKTVGPTDYGLEVVDDELSMIATFLDLIVNDWDPEALAGYEVHHSSWGYLLERAKEVHDWNLVPELGRMEKQSTGRHGNAQSDRWGFTQSSALKFTGRHVLPIWRILSSDNRMQHAAFEHVVFQILKQRCVSDRSAGLTPPAHTLSISTCTTRTPHFSHKTLTKWYTSGNPRYIAKVLEYWRNRVEMDIEMLEAAEIIEQNCESARVFGVDFRSVRTRGSQFKVEAVMFKLAKPESFVLLSPNRVQVGHQNAAECGPLIMEPQSAFYKGPLVVLDFQSLYPSVMIAYNYCYSCQLESQALNVFDAASFHRTCLGRIERFKSANKFGTTTIDPPPGLLELMKEHITISPNGMMFVKREVRRSLLAKMLSELLDTRVMVKSSMKRMQDDRALTKLLNARQLALKFLANVTYGYTSATFSGRMPCVEIADAIVQTGRETLEKAIVTVKSRVDWGAEVVYGDTDSLFIYLPGKSKDDAFRIGHEMADTITSMNPRPIKLKFEKVYLPCVLLAKKRYVGFKYEYPAQLEPDFDAKGIETVRRDGIAATQKMQEACIKILFRSQDLSVIKAYLQRQWEKLLLGDVSPQDFVYAKAVKLGNYALLEISEGRVPPPGAMVAQRAIKRDPRAEPEYGERVPYILFQSVPGEKQIDHAASPEEFLSDPRLRLDAKHYIERAIIPPLARIFNLIGVDITQWFKQMPRSLTVVHARSTQPGARKALLEEFLKSDRCRACGASGGVEEVERLCPTCLTKPGEVVYQVHTRMRTIHSKRMALRKICASCSSAVTTEEIECDSTDCPVLWDRMATEKEAIQIDEVFRLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NW37</accession>
    <name>A0A2X0NW37_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C002g01344</name>
        <name evidence="12" type="ORF">BQ5605_C002G01344</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY32285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NW37"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000007">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13650">
        <property type="entry name" value="Asp_protease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="11">
        <location>
            <begin position="363"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY32285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="735" mass="81243" checksum="3756EF83A5746256" modified="2018-09-12" version="1">MPTPTAPSHSPTYSQPAAASAAPHVATAATGHSPITGGPRPVARLTVDERAYLDQNHGCYRCRTLNADHISRNCPRYLSPMGASATPSTPTSTAPAPRPGPRMVAAIRTFQETGDSTVFAGLSSDSEDDNDPSHAPHPFPPLPVSLAGAHGTLLASALVDSGSPQTFLSEDLVQRLGLERRALEQHSKYTLAMQNQVPTVFTCTHFVRVPLELANGLWAAGPTYAEVAPLGKDLAIILGGNFIYRHKMELGLFPQPHLTCKANPIHAIDLLALSSQPCAAARVAAIAPVSDDEEQLRLAALDHRLRAEFADRFPADIPPVHLYQSPVRHHIELDTPSTVVNLRGYPLPKKYREAWYLLLQEHLAAGRLRPSRSAYSSPSFIIPKKGCDVDPTIAPRWVNDYRELNKHTIKDRTPLPLPDDILSTCSNAQFWAKIDMTNSFFQTKMAEEDIHKTAVSTPWGLYEWTVMPMGLCNAPATHQRRVNEALQGLLGTICFVYLDDITIFADTLEEHKARVRQVLDALRRAELYCSPTKTNLAAAECSFLGHIINRAGVHADPKKIQRIEDWSLPKTVKELRGFLGLVQYLCKFIPGLAEHTATLTPLTRQGLSSIATLWTPNKVRHFKAIKAIVTSLDCLRPPDHSANAAPFWVMTDASNQGIGGVLLQGQEWKVARPIAYWSRQYIPAERNYPTHEQELLAIVEALKEWRIDLLGGHFHILTDHSTLEHFQTQRTVLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NX03</accession>
    <name>A0A2X0NX03_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C012g07041 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C012g07041</name>
        <name evidence="10" type="ORF">BQ5605_C012G07041</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP-binding SRP family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NX03"/>
    <dbReference type="STRING" id="796604.A0A2X0NX03"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005785">
        <property type="term" value="C:signal recognition particle receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14826">
        <property type="entry name" value="SR_alpha_SRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17876">
        <property type="entry name" value="SRalpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000188">
        <property type="entry name" value="signal recognition particle receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007222">
        <property type="entry name" value="Sig_recog_particle_rcpt_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF1">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04086">
        <property type="entry name" value="SRP-alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="9">
        <location>
            <begin position="676"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="149"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="225"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY16953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="704" mass="75870" checksum="9F3E69C1F3AD68B4" modified="2018-09-12" version="1">MLDHVSILTRGGLVLYGHAFTPSPSPIDDLIRSVLIEQRSNEITSAGDHGLSTCDKGAYTLLWSFDNQFDLVFVIAYQRILQLTYVQDLLVQVKRVFVRQYEDKIDAIQQASKGKRQKPLEFGPEGWESLFAGWHATFMRLLREQEQSAAKVRARDGEGRPHSRVSSSQPTKRTPRPSAPFAAVREKHPEALTGAKAPEPSAKSTGDSLDAESIARNIAALRARQKAGAKGGREGKKAAEAEPASEQVSVRFLHGSQPSSTRLTARNDFLSSLDSPSRTPTKKAATKWSDSKVSAADLAAYDYSSDAPSSGTSTPLNKSLISSTALGKRTQSGLYEVADYATARDSSDDDDEVAPTTTATSTLSAFFGRLSLQPKALSASDLAPALVSMREHLMSKNVAKDIADKVCESVGKSLEGKRVSGFGGVKKEVRHALQQSLTKILTAKTSTDLLLEITRKRTTATSLTLSSSPKNGGASNPDPYSITFVGVNGVGKSTNLSKVAFWLLQNKLRVLIAACDTFRSGAVEQLRTHVRNLGQLGEELGGVGIVQDGVKMIELYEKGYGKDASGIAKESIAFAKENAFDVVLIDTAGRMQDNEPLMRALAKLVTVNNPDKIVFVGEALVGNEAVDQLSKFNRSLRGFSGVKNARGIDGMILTKFDTIDNKVGAALSMTYVTGQPILFVGTGQTYSDLRSLRVAHIVAALLQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NX46</accession>
    <name>A0A2X0NX46_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C014g07460 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C014g07460</name>
        <name evidence="2" type="ORF">BQ5605_C014G07460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY18750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NX46"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY18750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="69" mass="7967" checksum="053842ADC94F7F6F" modified="2018-09-12" version="1">MSRYEGRLVLDNFSKLLYKLYNAQIFFCALRSSRKAFGGPQDPRKPGLRRVVPDWTNYGPQMGQNREGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NXB9</accession>
    <name>A0A2X0NXB9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C015g07826 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C015g07826</name>
        <name evidence="1" type="ORF">BQ5605_C015G07826</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NXB9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY17582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="57" mass="6447" checksum="302CA081D5C953F8" modified="2018-09-12" version="1">MQLLEYLECLPRENSKVGMCVQALLPKKMARRFPIPVPGDFSMKAHATARVPRMSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NXR6</accession>
    <name>A0A2X0NXR6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C015g07996 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C015g07996</name>
        <name evidence="1" type="ORF">BQ5605_C015G07996</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY18169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NXR6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY18169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="120" mass="13072" checksum="13FB86CB392755EC" modified="2018-09-12" version="1">MVHSQKAARDRRSPKQRNHFVAEDIYWISIPFVGVQESLFDYFGGPRLAASLTSMWGARSPVCDFASDPYPAPSASLCALGGANAMIRAPPWSLVTFERVRAYTSILPPPRKGSFGSAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NY17</accession>
    <name>A0A2X0NY17_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C014g07481 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C014g07481</name>
        <name evidence="10" type="ORF">BQ5605_C014G07481</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY18811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NY17"/>
    <dbReference type="STRING" id="796604.A0A2X0NY17"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF38">
        <property type="entry name" value="CHITIN SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="673"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="705"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="737"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="770"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="804"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="904"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="941"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="9">
        <location>
            <begin position="241"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="191"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY18811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1043" mass="116720" checksum="EE5960D9EA504217" modified="2018-09-12" version="1">MAYFSSSDDSNGPSRYMTPPSRPCTGMTSSGSPAPYDGTGVGPVAGYYSESISTYLPQQGGSEGHYSQPFPSFHSLGYDRYDAYNDAAHRPTRVIRGPAGVANGINQQYDPLLDQQHDHAAGRHATNTLYQNDQYVESSIVDLNANTRPLRTKRSAARGAVADPGARMTGDAGQFEPADEETVVQERDMEDDQFEDSFEGKDEWEQVKDQGEEGEVGSPAISFAGGFGAPPPTAHLRRNLTNRRVKLTQGNLVLDCAIPTRLSDFLPRKGEDEFMLTRYTAVTCAPEDFNKNSYTLRPTLYSRQTELLIVVTLYNENEVLFCRTMHGIMKNIAQLCKRKKSNTWGPDGWKKVVVCIVADGRKAIHPRVLDCLSALGVYQEGLATNQIDEASVQSHIYEYTTQLSIDPDLRFKGLEKGIVPTQIMFCLKEKNAKKLNSHRWALQAFAPQLDPNVVMLIDVGTRPAELSIYHLWKCFDLDSNVGGACGEICAMKGKFWTHLLNPLVAAQNFEYKISNILDKPLESMFGYITVLPGAFSAYRYIALKNDELGHGPLNSYFKGEHLAGHDADVFTSNMYLAEDRILCWELIAKRGHNWVLKFVKSARGETDVPDQIAEFISQRRRQVDFMPCEWLNGSFFAGCYALRHTFSLTHTTHSRRKVFALYLQAIYNCLNLLVAWFGLANYWCFLMILTSSLEDPTFKLRGIKYVNLIVQYAYQGSIIACFFLAMGNKPKSAYWKYLTVIIILGLTTVYMVGATVFCTIKVIQLMHSNLIMFQIVVSMVATYGCFVVSSLIAMDPWHLVTSMFQYIIFSPVSINLLNIYAFSNLHDFSWGTKELATQEQDLGVTKKIGKDTVNMTLPSDQADIDVAYDRSLHSLKTRPMIVPPTLSQKQRDEQIVEYYQSVRTNILLVWVLSNGLIMSTVLQGDYASTFTGGHGNGRTQIYMVVVLILVAGMALIRLVGSTAYTIDRFVRIVGGRYQSRFGRKAAGAKGARGSANLTEPRGIRRIKSSTTLGGATAIGAMDDDHEKTYFEDEEEIMMDEKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P4L8</accession>
    <name>A0A2X0P4L8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g02580 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g02580</name>
        <name evidence="2" type="ORF">BQ5605_C003G02580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY41872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P4L8"/>
    <dbReference type="STRING" id="796604.A0A2X0P4L8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY41872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="761" mass="82729" checksum="55A94158F6D1F850" modified="2018-09-12" version="1">MASSNETTPIVSSNSRPPTLTRLLATCAPSSWFLPPPYHDGVCHSTATRVQAEAGTTAYDCVARLGGLKWDSPASPGARVLGSFFDILEQHPSLLDLFREELDAINNAPRSRMPRKSERNVEISFHRLLFGGLESATAALLNHYAAITEAVGASSASASTSATRPRYSVRLDQPESALRTQGDAVVYIELEAGNVVSSISIEYKRDNVHHSLAKVRQEGLSHIPILDHGAPVPLQKLEEEESKGADAVATKAIIQCVSSKSRFFLLLSVPFFQIGELVQHQSTHAATASDPVASTSAASASISAATAYSPAPPLKARYSLILQELARWVEPSPTTLNPNAAETLGADLPRRSLIVSFIALAFTAVIEVPKPDQAVIDTLLNPQFQPPNLPRRRSDPDLDPNYEPSPRVQKASKTSIEATGARRSGRLVGQPPRAQTKDSNRPVTPPISVGLQSDPSSDPLTPVTRIFSSPPASTDWSPATSPLSGSGLPSKSITIVQDRGFVIKASLSSAYWSTMSYTGTSRVELVEIGFDIVSSVPSDSPLASRLPSKPSPASDFIRGLHLSDVVLRWLSENPREELKDDRIPLELLDRFEPTADLRLEKEVGSGSTAGGWLAKVVQVNRPLCSSAKAEAPLVDHPAPNTTYFLKLVTCRYVGSVIRETLFYQHVLPHLPEHLRKHIPQYHGTYRRTNGNGYAMVLENVGKTMNELDFYGSPGELWEIEAAFRELGIIHNDVRAGNVLVRPNNGPLCFVDWGRSYLKLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P5J6</accession>
    <name>A0A2X0P5J6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="23">BQ5605_C001g00325 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">BQ5605_C001g00325</name>
        <name evidence="23" type="ORF">BQ5605_C001G00325</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY45706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P5J6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0229">DNA integration</keyword>
    <keyword evidence="18" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="16" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="15" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="16" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="17" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="22">
        <location>
            <begin position="505"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="745"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="831"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="747"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="21">
        <location>
            <begin position="760"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="771"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="21">
        <location>
            <begin position="784"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="SGY45706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="853" mass="94135" checksum="AC601B9D45AD34E3" modified="2018-09-12" version="1">MSSTGESDFPNGSGNRLYLKDTQGYKSWSQRAFINLRADKVWDVVNQSIDSLVADYRSTLVIAHATALTSVQVADKVAEYRERAIRRNDLACKYIANSISEEQMSHLIHLTSAYEMWDTLRGLHSHGRPSRTMDLLNTLAQPYSGDIPFKEFVNKVKIAMTDFQNLGAPLPHWLFAGMLVRSLPAQYDSIVGNLASDIDIHMDWNTFYPKLLMNVEMADSRNKQKESLSARIVDDTSLVARISTTAQKDYSKSYCSRCKALGHERGWRLCPSRNKDASAPASSDSNSNVAAIGVDESALMTYTFPYSRTMPRFPWIIDSGAKVHCVGDKSVLSDVVSEPLKISVADQSQIESPGHGSVTFLTSYGARITIKRVYYMPGAQCGFISIDRLLESMTYAVGPQSNLIFSIRGKSILRSLPGRGFVMDAAPVQPIMSSSPPSMVGANRLTGTCTLMEAHRKLGHQSPAAIVLAVKSGAITGITLKDEKVTPCFSCIQAKSKRSPFSNKSTEAPHALYRIFIDLGFVEHPNHHGDTIYLAIVDQYSTAKWTIVLKDKRAETIIEAWSKFQAESERQTGQKIKRVRSDNGREFDNSLFRALLEKQGIIVEFTAPYTPEQNGQVERLNGSLMGLVRSMLLDSGLPMRFWSDALAVATFVLNRRPHPRIQGKTAIEVLLGKKPSLAHLQPFGSTAFVHVPKERRSKLAPRSIQGVFIGYSGEYNYRVWVQLSKQVYVSRHVTFLETPSVVTLSQDRADASDPVHHSQPPHPPHPPPDVLPSTPTSPVVDPTLPDPQPPPVVPIGVGQQGGYLAVVPQEPLDGEAEVALAPREGYAIVRTGPNPGQFENVDPSNILPAGSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P7D9</accession>
    <name>A0A2X0P7D9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C008g04954 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C008g04954</name>
        <name evidence="8" type="ORF">BQ5605_C008G04954</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY78794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P7D9"/>
    <dbReference type="STRING" id="796604.A0A2X0P7D9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF27">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="434"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="87"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="197"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="483"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="229"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="487"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY78794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="552" mass="57910" checksum="4208BCA058E61B4F" modified="2018-09-12" version="1">MSLNPSGNPSTASSLPPPPAAYEDFEFSAPFHFDFFPSTSTNTSGLDSHTTLPLQHPHLASGSLHGESSSAASMLGVSGLSSHSNAPFTSNPFSPQNIASPPSHFSSLTSPPSSAAPSTSSNALFTDPSSSSTVPAHRTFLPSPPPPQELSTSISAAHSSISLNPSPLFDDSESALLSSFLTTLDVDPFFLFNPVLPPRMPSPPSSFPLDEGGKKERDRLGFGLGSIKLENREKQGEETTSREGEVDTEDGEGEDQAGEDREDEEEEGTPTDRARSSGVVVGRGGKRASGTGQRGRGGLAKGKKARRASVNESEAQDVEMVEVASMTSSTGRGARAVRSTKGSGGMGSGSRRLSSGARSKDAGRSITPLEALSGGRQDERQATEEAMMEGADDPPPPPPEVEEGDELEDEEHKNVEDDDDDDSKANKAPLTDTQKRSNHIASEQKRRNAIRSGFKDLVDLLAAGEAASGIVVAPPEVQAANDVLNGGKKKRASKGTGRGRGRKGEVAAGGSKSVVLEKAAAYILWLERGNQALTAEVKRIEVNMRQMGIGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P9E4</accession>
    <name>A0A2X0P9E4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C007g04432 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C007g04432</name>
        <name evidence="1" type="ORF">BQ5605_C007G04432</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY60442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P9E4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY60442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="109" mass="12154" checksum="6B884E5ED9CB2921" modified="2018-09-12" version="1">MFNQHSDGRTAHLKLNYRQVVGELLWVSGCTRLDISYAVTQLSKHCAGLKPEHFIRQMRRVLRYLRGTTKLDSIIMAGSAITCASKRQVSVATSSVQAEYQALSAAARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P9G3</accession>
    <name>A0A2X0P9G3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C007g04452 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C007g04452</name>
        <name evidence="1" type="ORF">BQ5605_C007G04452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY60591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P9G3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY60591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="174" mass="19258" checksum="DC3BF1AC1F20D6BE" modified="2018-09-12" version="1">MANNEPLLGYEGYSDSDWGSDVNTSRSTMGYLFKLAGGAISWSSRLQPRVACSSTEAEYLGLSHAAKEAVFLRSLLTKLGLDTSLPLCLLGDNQGTIALTQNPVFHARTKHLRMLEHFVREHVRNGEISVTYIPTHDMVADIFTKPLPRAIFQRHCDAIGLRRISSQEQGGVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P9Y9</accession>
    <name>A0A2X0P9Y9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C038g11677 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C038g11677</name>
        <name evidence="25" type="ORF">BQ5605_C038G11677</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000061">
        <property type="protein sequence ID" value="SGY91532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="526"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="788"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1402"/>
            <end position="1467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGY91532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1467" mass="160646" checksum="99B0EBFD8C2CE50C" modified="2018-09-12" version="1">MDDTSPPLATGVHPTFPADQLAALTSLLSGLTAAASGTVTTTTSSSTTRPAFPKHARLDGPKTFANWTRQLRLCLADDIRSYVLDGIVPVDWTPSQRSARDVVARELLANSIDSAEVSAVLDQIPTADLTAPKMYSTLKSRYAPDDATRTLELFSRLWSFRPMPGTVGEFDGWIMEFKAIAQEITDTKTTINDVLATLLLAIAHPSLESFKASFTDEQRTQRALPAIDSLADRMRVQLRSTNVPSTQSALLASSSSRPTRPKCLACRSPSHRVAECPVRAKHPPPGPCRSCKQNHWSFDCKKALGNGKKADTANSIADSQHHVGCIATGLLARRRQLRTNSFVVDSGATSHMVSDKSLFTTYRHIAPTKIGGIAGGINAIGTGNIAFVAASGHPITLTGVLHTPGLFVNLLSVSRLCDTDDVRVAFTKHGIDITKDGNNIAEGTRLDEGLYLLDADHSKCQHLALLSRSQSSVPLLTLHRCLGHLAPSSIQKMVAAGLLEGLGAGYSDEEVEKFVCNACLSAKGHRLPFPDSDSHSSERLGLVHSDVLSLPEQSLTGKRYLVTFLDDYSRKLWAYAIGHKSEVFSVFKTWLAEVELETGTTLKVLRTDNGGEYCSRAFTEFCKARGTRRQYSIPRTPQQNGRAERVNRSIVEGILALLADAHLPKTFWEEAAAYFVYCKNLVQHSALDKATPNLVWQGGRTTASALHPFGCAAWLTVAPELRSKLDPKAVRVLFTGYDLGSKAFRFYDTTTKKVTLGRNATFLDTEFPGLRCDSAEQDDDTHFASAPFADPPTTVKSWTPLPQAPPDPLDAQPPDFSTYRKPASAEESPDELDLIGRHSRDESPDEIDFLTRHHRAFIATDDDTSDTEAIEPVKSITSDPQTWREAMSGNKREVWAKAAADEFNSMRDDFKVFTIDDRSTVPAGATVVTSKFVWKTKRNALGEITGHKARLVAQGNRQRDGIDFNETFAPVARFSSIHSLLALAATNGLHVHQADIDKAYLHGDLDHDIWMTAPRGFDLPGDKVLRLRRSIYGLKQAGRIWNRHIDASLRALGYTATGTDHCVYSRLDDRQHPHYIALYVDDLLMISPDLAEIERVISGLEQRYGVKRLGPAEYILGIQIRRLDDGSVALSQERYIMDVLARFHFDTTTRGTTVPMTPGLSLTAIPGQATERIRSWYLQAIGSLLYISLGTRPDIAFAVSYLARFANNPGHRHWIAVKHILRYLRATYRDELVYTRGQARITGVVGYSDANWGACVDTSISTMGYVFYIAGSAVSWSSKRQSRVADSTTDAEYLALSHAGKEGIYLSQLLEELHVQPVAPAHIFTDNEAAAAVAHDPVRVSGTRHIRLREHFVRDMVNRGDISLSHVGTSDMVADIFTKALGPTVFSTHCYALGLRTRHPRLGSASHSRGGGCEESTLSSTEAPRSSRAPASPPPCGGDLGARDCLSEQAPADSGARPLGRPLEVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PBU2</accession>
    <name>A0A2X0PBU2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C004g03035 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C004g03035</name>
        <name evidence="4" type="ORF">BQ5605_C004G03035</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY69590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PBU2"/>
    <dbReference type="STRING" id="796604.A0A2X0PBU2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="90"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY69590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="194" mass="20439" checksum="5A0222848B6268E6" modified="2018-09-12" version="1">MTSSSSSSTSATQAKVLSIIRQRCETVLQAGTSEPGFGWQQAASCRLGDVQVSGVDLAEDDEEDTAPRKGAQALTTVELEVDDGMCNLSGNAHGGFLAWLIDHCSSLSLIALAGHGRWATSGVSTNLTVNYISAAPSGTPLKVVTRVLQQSKTSSLLETRVEHAETGRLIAFGTHVKQDTPSLMIKWPKGAAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PCW4</accession>
    <name>A0A2X0PCW4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C005g03568 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C005g03568</name>
        <name evidence="2" type="ORF">BQ5605_C005G03568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PCW4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY77154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="71" mass="7746" checksum="3459B09B0BD54A8A" modified="2018-09-12" version="1">MRAVLQRLHASASEGVTEDDTPRRRAAYSSQVMTINSVSRPKSKEREDGTSGNGQENRVVLANEEEASIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PGM6</accession>
    <name>A0A2X0PGM6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C027g10339 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C027g10339</name>
        <name evidence="2" type="ORF">BQ5605_C027G10339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PGM6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ28448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="302" mass="33167" checksum="5BAED0F3E39BCDAF" modified="2018-09-12" version="1">MGRNLRHFQSTRHRTPRPPPLLLSDLLSVDSSSWKKRSLATDHERWVGEQDGLTTFMLSPFTFDFYSPTASPASPRTPRQHNSSAPSSPILAMTSTSRAQAHNVRKEKRLSAVLSAEHSEDYNGLLLTETSLRSLHVLGYTSLSTSRSSCISTTSSSAPSSRTASPNHFKTSSPKSGRYPSPSLNKSPEVGMDPLDVFFGLSSAAEAKAFRSGLIGLGIEIGVKGGWEGVEDLEPLLTSNVKDVQEVQPQEIITPIYVAKKTKQDSKRPDSKRAIRKSKSVKERLKHLFVASSSLPLYQQCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PGS0</accession>
    <name>A0A2X0PGS0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C027g10389 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C027g10389</name>
        <name evidence="2" type="ORF">BQ5605_C027G10389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PGS0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ28618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="685" mass="75045" checksum="BAB48BB4A8825413" modified="2018-09-12" version="1">MLHIRRLRILEDLVFLLIILSTLPTPNLAWPRRSSLGRNAATTVPKPDSPVQPLEAVGLPSSRSTSDAPAHPAADFERQNEEIRAALLRRLSYFKEASGAPHSSPLELRKEAQDFSEAAYRFEQQDESALLSRDRSCFSQALPSGASSCQSLAGSSPHLNELRVKTAIKMALCEIRTSRSTRGPKECQPFEAGTDGSNAGEEPDPMILCSAYRRWEDTETARELHQSTATRLADFVQQLQDLELVKKEGMTTESEQRARAFQDISHHITSSLEPLFAAFRTNGAAQLDSFALLRSELLHLIQSIEPLVSRSLEGTLQDMSHMLKDVALEHRNQLEKVSQNTVARTTQELERSLLAVHDAIETSIADLNQSSGQVVKEMVGLYAAVKAGEHVANANFPAGNVFHRRFQWTDKYLIFIDGGFGAQTILGLSDAAEQLGSSLSTSLELASRSQDLQASNLEGLQRDVSVLSEAVTNLTLRTRPKLLSKNLGWLVALASRLRFDPEDFVIATMSALLRLLGVWKTGIAVMTMACIIGIAQGDWLPTSLLVRVIGSIAGAGALVRMIGISVVRIRKSRAAVQDSQHPLANGRSPTGLPMSELALEASRFALSNPPSHLRAGIGSFTRPRRMRCIESNRAARGWPAFVIAESYGTWAAGRPSWHHRGAEFRQPESELDAEPVDEACDGACV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PH55</accession>
    <name>A0A2X0PH55_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="5">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C036g11510</name>
        <name evidence="11" type="ORF">BQ5605_C036G11510</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="5"/>
    <dbReference type="EMBL" id="FQNC01000063">
        <property type="protein sequence ID" value="SGY95699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003840">
        <property type="entry name" value="DNA_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02689">
        <property type="entry name" value="Herpes_Helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="9">
        <location>
            <begin position="356"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="8">
        <location>
            <begin position="1031"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="10">
        <location>
            <begin position="1331"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication helicase" evidence="7">
        <location>
            <begin position="1426"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="308"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY95699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1688" mass="189065" checksum="BA39C97BE24B0B37" modified="2018-09-12" version="1">MTTMQPILALRHVYEPAPHVSIRDDLGPQTAVCTHCKARHWECERSKSTRHFGACCSQGKVRLPPPPQPNLEYRQLLEGSDSDAKAFRENARSYNNALSFTSLAAHCWDQTQVDTLGPPVFRVFAFAQTSLIDPAEAANTRLQGPDSAETRIQRSTLTKLESMLRTGNCFVREFASAKGRAGWDTAKEWVLRLCLPPGRDRRTHNLPTSSTEMAMLICDSDTNTGDRGPQDLILQVHGDRCPDGRPKYQIVSSLHPSAMPLRYPLLFPAGEDGFHPNIPLCGFNQAGPPIARNREQIDNGVQLRELLDGLGPDEEDEEEDDEDEGDEEDEENGDGERRRSNKRGRGGSTRVSRSQYFAYHLHERDDYFSIPHVTQRLFLEFVIDGYSQVETDRLNYIRLHQESLRLTTAQGITDAVANGLTPDQIGRSVILGSTFKNSPREITQRYQDAMACVVKYGKPLLFITVTCNSEWPEIKAALGPNDKACNRPDLIARVFEAKLNRLCDDVFGNKQRAGCFGVVLTHTHVIEYQKRGLPHAHILITLAPDDHPLSTEAIDKMISAEIPDPSRYPDLHETVTKHMLHGKCGGNSTQPCMEKDKYGHPRCKRHFPCEQNPHTRMHPEGYPLYRRRFRHAVVKGGVIYNDGDCVPYSPYLCAKYNAHINVEAVTTIGAIKYLFKYVYKGPDRAVARVERAANGEGAREDEPVRDEINEFVEGRYISAPEAVHRLFGFSVGRVWPPVNRLPVHLENQQSVQINPNEPLPLDTPPTRSKLTGFFDLCAAAPDGELTTTLLYTNVPRYYSWNKEKLRWKRRVHDRNVIGRIYTVPLRSGERFYLRLLLEVVMGPTSFADLLMFEDVVYPSYRAACAARGLLADDGEHHICLREAAQIETGDQLRRLFVFMLIHATVANPPALLDRHFASLSDDARYHIERYEDVPVNDQTIRLWTLNKIRLLLAANDRTLAFFDLPELTEDEVRLFDRLEERLPRFDRQQCAQDAEAAHACLNHDQRIAFDECLCAVELDVVDQMRDNNLGPQHVFFLLAPGGTGKTFVENALLDTVRARGDQAIAVASSGVAALLLKGGHTAHSTFRIPLDTLPTSTCPVDRESDLALMLRTTKLIIWDEAPMAHRFAVEAVDRLLRDIRETEEHFGGVTMIFAGDFRQCLPVVPKGTPGQIVDASLIKADFWRDMRVLRLTENMRLSSNADAMDEAQLARTRDFAEWLLTVGDGTANMHPYDKIALPDYLLLPDGQRTAEGLINFVYPGLRTVNKESLEDLIQLFSRQAILAPHNATVDRINAKLLEEFNGDYIEYRSADEVVEAGETGGGMAPELISPEYLHSFNPSNFPAHHLHLKEGIPVVLLRNLDPDAGLCNGTRLIVSHARSRVIQAIILTGDRAGTTVFIPRVRLETNATGSRQLGFTMRRLQFPLRVALAMTINKAQGQSLDRVGVDLSLHPVFTHGQLYVALSRAMSVDRIKVLLPSRDPADDDDGLQAVDRAAAAATATPNPVFRSVLRAMNGEYPPSGRVRDEPSPPALLVGGDWNCVESQPLDSENQNGTNYGATTNHSAPGTCRRLDCIYVSPDWVDLFHDHKIWAPVLKSMHSMVVARFPVPGAIDIGPGKFKLGLHVIEGDATCEYLTSIVRTLYNEALLQTLNDPPAAWTSTKHHLLPELQALARTSGFPFRCLDIYLSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PHA6</accession>
    <name>A0A2X0PHA6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C036g11560 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C036g11560</name>
        <name evidence="3" type="ORF">BQ5605_C036G11560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000063">
        <property type="protein sequence ID" value="SGY96334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1199"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="559"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY96334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1802" mass="200122" checksum="169E69C177DBEA0E" modified="2018-09-12" version="1">MSTGDPGPPPPAPPPPVSATSVQPPRDQIPISSKKTQATGPATAAPNYAAAASQATQSPEQQQQQQQRAKALGSLLQAMGAVPGNRMDRWVQAVYFAELYPVATATSLKFSALNANRSVENIFDYALEVTLSHQSALRASHANKTNLVACVTRLLLPISPICFEPGVPLPDHLAAYRPQILGVQHSSILRNGAAHHRVTVGFVTGEARDAALTTPPALTWRSAKARFAKSHRFHHNMVELRINVGVQGVPSMDAIIKSFQLLVQDLSGKGHSCQLVQVLRIISVDNASAFAHVAGDYSAFLHFDDDSLFKRPNTTLKEILPSRIGLPTRGIPVTALRHDYEKEVACGRCHFVGHVGTCGLDQESKRKEAHNGNGNGNTNPNKNTITNDTNIVEAEAPIPVPVVNRIASQNRFAGLEVEEGQEEAVTGQSGQGPEESGAEDAGDKADDEDLEDSEMESEATAKTEVIKLKSEDESVLEDCGGSDGEVIDEDEVMADGRGETEGKVATEMEEREVATEMEEEEVAMEVDDVDEAGGATKAENAEVTDLGETNRLDNDDNSDTTATAATASRKSTPHEPTPPLSPETLAKSLREGEEWDRIRANWVEQARLERDQSIERRLDAETPLVRHNFATWDEDVIIKGKSRVVVKDGTEGRRVTRSMSAAAAMPVGVTKVDRGKAKGVAEEKRWSDHEPEDDRFDLNYPLMIKHTIITWNVRRGMGVPEKQPLHQTAPLATHQGRVRGQALHQPTLSDSPLIDAELLRTHSALDGRLLVTSFRLRGDIKILEINNVYAPVDPKQQAKFFDKLLFHKTQKSHLRLLGGDLNDCPRPEVDRRNQSRRGHHWPILIGKLDLAYTDCIRYKHPITPSFTRPNPNRKRPNSFSRLDYFFLQRTHQKRLDQASTIYDYPKELSDHRPVLIVLALSDDPDATLPQLSLPTTSNQLHRINTTTFKTVEFQRMMEGWLEGARGEEPVGELEVILKACRDRGGEMARRLHRERTERMEYLVGRVQDLEAIPEWGEAETAEWTRTSEELKRAVEERARLLRIRAHVPEIPSEERLSRPVHAKLAARNSDSKITALRLSNRELTHDIDVALDHTQAHFQRLYHIEPRDPDRVDRLRDEFLAPIRAARTCDDPRSDPLFLRRLSESQIDLLQRPITEDEVVAVIGTTHPGQSPGPSGVPYELYQTAPKAWAKVLTKAYNAMIERGSLSPKQGQGLVRLIFKRHKKNADRAKLSSYRPITLRECDYKIFTKVYVARLNQILPDLLPPQQHGFVKDRRSADAALHLRLLIEEVGARRTEFPAAALLSLDQSSTYDLVEHDWIFAIFDALGAPATFLHVLRMLYSGDSTSARYIINGFLTAPVRLTCGLGQGDPASSSVWDIVFQPFLDALHCRNIALNLSIPALHPYPQSRAITLLAFANDVVVAVAGLGSLNLLDDLALDWRHATNGRLNTDKTVVLPIGRRWDPGQRPLVVKAAGESLEWIGLPFDPSGNTELAYANLIERLEATLEGVQHRWLTHHTRAFYVNRYAIPKILHFLAANIPPPEVVKKLNDMLVDFVRGGKGRTSYGRDIVFTAKLKGGLGVIRMQDVVDAVAARIWDVLLGGLGAIWQGLARAALQRAQSDLDLATDLWPHPSTPIPSDLHPQWRAALGVPKQQDTQVNPRTLTTANLLALPTLLGSLHTPIRGRQTIDAVHIPDYLRFQGYPKVADLYQRELYAGGGEYDRRGLPQRLAIAAWYRFTVDRHKNTPLAVAVAAGRLNVPPRIGTSAPLEAILPKPVARFAMEQRLPDPVLPQQASQYKLLNMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PHK7</accession>
    <name>A0A2X0PHK7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C110g13215 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C110g13215</name>
        <name evidence="6" type="ORF">BQ5605_C110G13215</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000104">
        <property type="protein sequence ID" value="SGZ30200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PHK7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17923">
        <property type="entry name" value="DEXHc_Hrq1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18797">
        <property type="entry name" value="SF2_C_Hrq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055227">
        <property type="entry name" value="HRQ1_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018973">
        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47957">
        <property type="entry name" value="ATP-DEPENDENT HELICASE HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47957:SF3">
        <property type="entry name" value="ATP-DEPENDENT HELICASE HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="MZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22982">
        <property type="entry name" value="WHD_HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="170"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="389"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGZ30200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="959" mass="107217" checksum="B8B3B0603B2A8F97" modified="2018-09-12" version="1">MQRQNSAEGKTPVRSSSCDKVPQYSKESTTSLIERRNAKFSAAVSELLVACAAAVPPKDPVTLLLAATDHNLPVKPGDEDVERKRLTEKREDLEFYQRNPDWRPSIEKIVIELMHQKEYRGQIVENGHRIFDARKGVYGDLDLPLSTSVWDALYTTKEITQLYSHQAQAINTLDAGYNVIVSTSASSGKSLIYQLPALKELEKDNDATAMYIFPTKALAQDQKRALAELLAACGGFEDVKIATFDGDTHREDRDYLRDNANIIFTNPDMLHLTILPREESWRRYFSNLKFVVVDELHYYAGLFGSHVAFIMRRLRRICAAVGNDKVKFISCSATIANPKEHMQTMFGLEDVVVVDVGGSPTGKKEYLIWNPPFIDVQDPKQGRLNNMYEASRIFRFLMDRGIRAIVFCKVRAQCELLMRQVRTDLMVEGRSDMASRVMSYRSGYSAADRRRIEQEMFSGQLLGVIATTALELGVDIGSLDTVITVGFPYTLPGLRQQAGRAGRRNKDSLAMLICDPWPLDQHYARNPDQIFTSPFSELGIDLTNPIVMEAHLQCAADEMPIQIEVDTHYFGPELARVVRDRLVVDEEGFYHCHPKHKPYPAKAVPIRSTEEDSYTIVDISEGRHEVMEEIETSRAIFTTYEGAIYHHMGRTLLVREVNHDRKIARVELAQVEWRTRQRDFTNIDPLEPLTIREITGSPCTASYGLVDITSIVFGYFKTDKRNNILDTVNISSPPFIRRSHGLWIDVPASALEILLLKNLHPAASIHAAEHALMSLTPIVAMCTEGDVRTECKQPEKEFASMPSSRKRPARLILYDSAGMSGGICAKAFDHISVLIRQAADTIANCICTERCPSCVASHMCSGANTIVSKLGALVVLDSILNRPIDIDAIPLQEPAQGIVPGGSIDLAGAGVRRSLIDAQQRRTLLGGGPGSEIPQVPRMAEVQERTRYDITKGGGFMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PHN4</accession>
    <name>A0A2X0PHN4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C119g13280 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C119g13280</name>
        <name evidence="2" type="ORF">BQ5605_C119G13280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000109">
        <property type="protein sequence ID" value="SGZ30370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PHN4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ30370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="71" mass="7941" checksum="184D0EC4655ED6CF" modified="2018-09-12" version="1">MSSTFASPSGIWHHKGDSLRHSSVQDSMTGIIDDQQLCPPKLLQLTTRRDRSDLSQKCSQVESDDDHDSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PIQ8</accession>
    <name>A0A2X0PIQ8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C031g10990 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C031g10990</name>
        <name evidence="2" type="ORF">BQ5605_C031G10990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000068">
        <property type="protein sequence ID" value="SGZ07063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PIQ8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ07063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="721" mass="81201" checksum="426B12D8168FA662" modified="2018-09-12" version="1">MSKPRGESPRYQRSVSIEGPISAAAPSRSNGAWGGAEEEGDDDARPPLASSRTTTMTGSVTYPPTRDGECVISFDGREVQRKDSVWSVSVQSQFDGDHVSSVDDDSDEDDEDGVNDRSELFPIKNKGRIVKSERRNSREGPWRIESRESRTRPEDGWIVGGRRWRGAAPAVAGLVVLILLLLLTSMKVMDETYIREKIEGREESKVVDSAELGPPRPALGTKVKLDSDPEGEYIAPSRLKLQEEVGTEPKFLVMDGDDARNFYDLRVIIETVLNLATISSRIPVIPGHVWMRSCRVKRKDCTQNSLDHREESWRGPEGWKIGIEHLIDIPHLRKIYGLVLTQSEFSTLFNVTPKMTLWSQAGVWNMESTALDGLSTSEITSNEWFNDAQFVRMDTNLPSWTEPESDAVIVGLDTARVREMQVDNAGRVWSLDRARELLTKTGFKVDGDNHWLEEALRKVEQSRVYSFDERTDQIKTVAQPVVLMADRSRSFSFTDEFLTQPRHRDASLLYVSGPIWNEGRLGGVHFASQETRDQFVNMILEAIRPPKAYIEAGKMVAENMVKVNEGRKWLATEMTSVAAVHTQGSSSAEAKILNQLGLLEKGLAELSAHKAKNLPSKEHLQVLSRIKYFLATDETDPATLVTYQRRRAVLLKDLLSEIELKILGWRAMFGDLLQLVEQEVMASSDYFIGCRVSRRTGAVLDARMGPRFEREEWSWTLDEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PMP1</accession>
    <name>A0A2X0PMP1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C055g12641 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">BQ5605_C105g13179 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C055g12641</name>
        <name evidence="1" type="synonym">BQ5605_C105g13179</name>
        <name evidence="2" type="ORF">BQ5605_C055G12641</name>
        <name evidence="1" type="ORF">BQ5605_C105G13179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000078">
        <property type="protein sequence ID" value="SGZ11485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000092">
        <property type="protein sequence ID" value="SGZ29178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PMP1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ11485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ29178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="76" mass="8876" checksum="9B61F8015E11FC07" modified="2018-09-12" version="1">MESLPCLHIHTRWSVGSVLKYTAVATTFEERIDSDRPQLVVIFTELGDLDVPFIRYIGGSRRTHNLLWIWTWSTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PND1</accession>
    <name>A0A2X0PND1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C048g12378 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C048g12378</name>
        <name evidence="4" type="ORF">BQ5605_C048G12378</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000110">
        <property type="protein sequence ID" value="SGZ30483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PND1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016017174" evidence="3">
        <location>
            <begin position="18"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="216"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="216"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ30483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="402" mass="42857" checksum="33F2CC6242F17035" modified="2018-09-12" version="1">MLETLSVLLWFGSIALGAPVNNPSGGARSTVATGSETSATAPQARNLDVREVINAATPPTPDGVHNGPATWFTQDNLAGACGKYNLDATPLVALQYLLYGDTNSESQYCGRYVNITNTVNGKNVIAIVADACPSCAGAYALDLSLGAFDLIGDRDADAGMLSISWSFLPKTYKPAFVAPILTEPTSVKTTTKRAVRSDSARSATTSKTGVVTITQKTTTSGSGGNLTTTPVKRSTKKPPSATSPWVDARIRKNGITAFRATRCGTNKGSIVSWFSTKSTTDSTNGNSWCGFPYDDTTPGFAISLKTMLANFGNNYEKAAKAFCGMEAEITSKSGKKIKMVLVDAFDDRWVRTPNSIDMITNSFAKFNGARTTNKNVVQMDASWVFTGRRNLRYQFKGVGSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PNJ4</accession>
    <name>A0A2X0PNJ4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C027g10423 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C027g10423</name>
        <name evidence="1" type="ORF">BQ5605_C027G10423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PNJ4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ28722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="93" mass="10190" checksum="764BD75BB1DFE80B" modified="2018-09-12" version="1">MPSREAAARNRSTRRRANWFFQTSGSVGQCANSAVRGPPACHGASLHGAPPSFSLLLFTPYPSPPPARDIRLKRSSRKLCNEYGSKKWLPHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PQC6</accession>
    <name>A0A2X0PQC6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">BQ5605_C041g11964 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C041g11964</name>
        <name evidence="14" type="ORF">BQ5605_C041G11964</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000119">
        <property type="protein sequence ID" value="SGZ33429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PQC6"/>
    <dbReference type="STRING" id="796604.A0A2X0PQC6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02669">
        <property type="entry name" value="Peptidase_C19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033809">
        <property type="entry name" value="USP39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF16">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SAP" evidence="13">
        <location>
            <begin position="9"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="UBP-type" evidence="12">
        <location>
            <begin position="207"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="11">
        <location>
            <begin position="352"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="43"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="158"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGZ33429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="752" mass="84723" checksum="B6B58AB20446BF83" modified="2018-09-12" version="1">MSTEADQDWSKLKVVQLKAHLKDLGLAVVGKKDELVQRLTDYYEQQQQQQQQQQLSKPEQEHETEPEPAEPELELEPANDDDNDDAAAPVEAPAVDNSSVQEVEITTQALNPRIRSAESLATQNGHNELPKPKRAKLDIDPATPTQPPPSPPPPPPETKQEEFQEHSAHAPHGDDDDHSKPKDDPEEPPDYELQFQAIDDQDDSTRPTDLYLDTINRHALDFDFERLCSVTLSQNNIYACLVDGRYFQGRGKSSPAYAHSIAEDHHVFINLTTQKVGVPPHQSSSHASHADSCPIRLQVHVLPDGYEVNDPSLDDIKYHLFPTFTPILLQRIDAAENPSYDLAQKPYYPGFVGLNNIKANSYMNCILHALVHVTPLRNYFILDPHVTSSDATELVRRFSMLCRKIWNPRAFKAQVSPHELLQECANASAKRFKITQASDPLEFLGWLLNALHRDLGGNKKPKSSTSTPDFGELGSLAFAEWNELAPPGVIYSAFQGEVRVDDQQVLTTGEYGGKPRFDLDRGTFRLTSIFARSILIYIFCTLPDIKSTTNPFLFLAIDLPPPPVFQDSVETNIIPQVPISAVLAKYDGKTTQESKGMLRRWKLTRLPPFLILHIKRFTKNNFVEEKNPTIVNFPLRGVDMADYVEGNQSIAQYYDLVSNITHSSAAGTAREETTWKVNVHLRTQRDLETGKLSRPGKGDDDEKWYAIQDLIVEEINQQLIPLGESYIQIWERRGAVNQPLVVEKPKPKSTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LNU6</accession>
    <name>A0A2X0LNU6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C011g06366 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C011g06366</name>
        <name evidence="2" type="ORF">BQ5605_C011G06366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LNU6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY12032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="312" mass="35263" checksum="5251596FFEC20108" modified="2018-09-12" version="1">MYIARGARTPQAPRFRRASGQLLRPTTVVCKAIALRENARSYNNALSLTLLAAHFDQTRLGILGPRIPVVNQRSSLCSNVADRPSRHRHSTWTQRRRQSHTKAYFDQARVRLAQAGDTAKEWVLRLCLPPGRDRRTHNLPPPSTEMTMLICDSDTNTGDRGPQELIVQVRSHRCPDGRPKYQVVSSLHPSAMPLRYPTLFAAEENSSHLNTPLCGFHQAGPPIARNREQIDNGVQLREVLPVSVWMTNEEDKDCDDEDEDREEGDEEDGDGERPVKGSRWRVSRSQFFAHYLPKATSTSQSRIAPTVPSWSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LQ37</accession>
    <name>A0A2X0LQ37_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C010g05950 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C010g05950</name>
        <name evidence="4" type="ORF">BQ5605_C010G05950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LQ37"/>
    <dbReference type="STRING" id="796604.A0A2X0LQ37"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="836"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="175"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="355"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="430"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="430"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="451"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="505"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="641"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="666"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="721"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="753"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="782"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY13702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="864" mass="90987" checksum="BE04753F3845C61A" modified="2018-09-12" version="1">MQPHLRDFYQNNNPQLQQYDACQYGDVLPFYAKPTPIQLPAHPNPTLLPAPPPFDLDFDYLRSTNGGSLSGTDPILDGLRPAAPSSASSGRARDRARVTVRGGSPPASSSADWPPVPDLIPDSPSSFSPPPPKTFLVPPPPSSTSSSSSRPGPGPRPRSSFVHPAVAGAQAVAVMAPPQQQPQQPPAAPDSLARNDFRSASVPPLGEIPKPRRRRTQEWSEQGSFVSSVYAPNAPALVAAAVASVTAAPSSSSSSLHPQLPGFAPVGTLPYTFSQLGSASTFTPSPTEEAGQSSFYAPSVDHPLSLHEQQDLLDRVKRDLNGVDLDSIKGPLRALALSGGPSTHDLAPPNQIMTMNDLSPHRGTRLVSKPLSSTRDDEMARKTVSPQEAFLDYEDVDHRLHAKSRLGNNISSSFGLGVGASLFAPLPTVASSVPRPASSPVTGSRSAEGAPTSPHTSPPSVTSLPSTSPRHNQGFALFPRKPHPFAVPQNAVSWAERQAGHESNDAADDYERESSDGDGDGDVEGDKNLQPSNRAGEFGSGTIAGKQPARSAAAELFDSDEDDRHSLPSVYARSTGGSDHEVVGHFDDDEASIGQDKPGTVPKAVKATIDETLHSTSTLTDRPVSLGTASVSSTPPPPPSALTNEATSSIPAPALAWAKPPPHPMRSSSQRTLETLQPAPVGGDDIADALGEMDTVNDAPSPGNGRGSISAQQKRSRSPAAEEDDMEDAEGDDDDDESVDDASFQDSDGSTKKPPRAPTKRGRASAAPHKRRRRVPSARIPSAASTTATTSSSLACSHKMPDGSICGVVFRRPYDLARHRGTIHGEGGKAGKKHDWICKQCGGSFSRKDALIRHGRIRNHKAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LR88</accession>
    <name>A0A2X0LR88_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C013g07145</name>
        <name evidence="11" type="ORF">BQ5605_C013G07145</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY14882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0LR88"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2230.10">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF24">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06337">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00695">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51283">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DUSP" evidence="10">
        <location>
            <begin position="242"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="597"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="207"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="978"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1087"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1402"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1486"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="46"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY14882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1557" mass="168655" checksum="80B33EBB6F216B09" modified="2018-09-12" version="1">MRSDRGRESQTDPDAAAAAAHPHPHPHPHPHPHPHPHPHPHRPRTPLALALALSSSSSLASSSPTSTLNLASNPHSSATAAAPPSPTLSARKRALSDASQSSESSVVKRHLSVDPTGTADSPSDIDSLGASRLDLEGSSERGDDVDDDDDEIDSQSGDVAMDDASAFAAASLVRPTTRSSAAAAAAVAAAGSHTDDEEQLPSYTSLTLASTAATPSSTTMDDDDEGDENAVPVSLERTEPPPDGANQLALIQDWLRDAQNEMAPGDSWYLVSRTWYRRWQAACSGVRDEKNDDDDDDDLSIENLGPVSNADILDQSGALKRPVQEGRDVVLLSPQAWDFLVKWYGRSSLPIERQVVSTGGFGSERVEFYPPTFGPVKVLPSESLAVNVSIPIVESTPTISLSSGSTVQELKELCAIQYGLSSGREIRLWRLPADEEVGLAAPLLDGPGHIFAEKLSRVAQAGHSVELVERGEISGTTSLNDAMLTDEMTRLAIEEQNEDGKWLVDETSIQASTSASGSSSHHSSAAADDKKKLFGTQFFDRFAVIPRNKTGVERPAASNHSGSTLGSGGGGAGLFASLGGALTRSKSNSRSGQRGLTGLTNLGNTCFMNSALQCMSNTKELQEYFSSGVYKSEINRTNPLGMRGQVAESFGQLIERLWSTSSGAYAPREFKQALSRFAPQFSGYGQQDTQELLAFLLDGVHEDLNRIKKKPPTSAPDWEGGGDKEMFELARTCWEQYRSRNDSVIVDLFQGQYRSTVVCPDCDKVSITFDPFMYVTMNLPVSKKWEGRIYFVPLDPKRARYVVDLEVPKNGTIKTAKALVAKLVDCDPKHLVTIEEWKGKPFKAWYDDDMISELNTERDCLVFWETSGPFPQPKPREHGRTKPLRMDPDAPIVIPVMHKARSKFSGSSHRSYGASNHGDAFGSPFLLTLTCEQASSVEAIELALATQYARVTKRGEELLEFVELEQDSGVAATLPQVHSAPTAGSSKNLPPTPPPEASMEVDGEISLSTAASTTASSKTPRSKGPFQIHVSKHPVTKYGLPLGQRDCENTPVVPLESRLPRAPSPETDMFKTAPAPAPGHVPGAFPTVEEESSSAMSTDALTPAPVEPGPQSEAAVSTAESTPPPPAFKPLVKNGDFFHVEWEPAALAHYFGGNGSDGDQATWLQVESLVDPVLAERRNRPRGTMKKAITIQDCLNEFTKEERLGEDDTWYCPVCKKHQQATKKVELWKVPDVLVFAFKRFSANRYSRDKLDDLVDFPLEDFDIEPFVEGVKVERRLAGETGAEEPESLIYDLYAVDNHYGGMGGGHYTAYAKNHENGKWYDFDDVSWSLVGLCDISPFPSLSADMCSLYSRPQSRVSEINNPEAVKTKAAYLCFYRRRTTRPIGAKSRELIDSAIQSRNASAANSDAGVPSGPNSLENTPFGSTENLPSIMHSNELLHSPYTSIRQTTTIDDDEEDDLFGNGAGDTTLSSTLRARPNYFKGTLASAMQDSSSSSSDSDVAEPGSPRGVLGGLVEPRDGEEDWNPLNGEDGAWSGVGGEDQVVEVVEVKLNDEERVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LT36</accession>
    <name>A0A2X0LT36_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BQ5605_C015g07890 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C015g07890</name>
        <name evidence="11" type="ORF">BQ5605_C015G07890</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LT36"/>
    <dbReference type="STRING" id="796604.A0A2X0LT36"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015215">
        <property type="term" value="F:nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000075">
        <property type="entry name" value="Nicotinamide adenine dinucleotide transporter 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044712">
        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45683">
        <property type="entry name" value="MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="17"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="135"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="236"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY17786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="349" mass="38290" checksum="C7ACCF17070CF02C" modified="2018-09-12" version="1">MRVTLTDRDPKGSTVWFHGAESMLAGAGAGLVTSVVTCPLDVIKTRLQASGATTAPRGLIAQDRVGDWRELRLHEPTGDGRWTAGTCVHIASTAGFRGFYRGLGPTIIGYLPTWAIYFTVYDKIKSTMGRSRGNDDPISHIVAAMVAGATGTIVTNPLWVVKTRFMTQTTGPNEPPYSHTWDAIRRIYHTEGIQTFYRGMVPSLIGVSHIALQFPLYEQLKVYNRPPDGSDIPSSTILYCSSVSKMIASVATYPHEVLRTRLQIQKNVRTQTSGPIPHEGATPPVARSYEGVAALFKRILRTEGPSGFYRGMGVNLIRTVPSSALTILTYEVLMRRLYALSHPQPERSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LT40</accession>
    <name>A0A2X0LT40_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C011g06362 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C011g06362</name>
        <name evidence="4" type="ORF">BQ5605_C011G06362</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LT40"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retroviral polymerase SH3-like" evidence="3">
        <location>
            <begin position="34"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="230"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY12026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="745" mass="82448" checksum="C8FB3555291513BF" modified="2018-09-12" version="1">MEVLVVCVGLEGKTAYEVFYGKKPKVSHFCPFGSTVYAQVPKSKRSKLESTSVKGIFIGYNSEYNYRVLVDPDSDHKVIVTRDISVLEHKSEQVGVPEVTTLPVGPDEEKGPVDNDEIVVDELQDQVDGEQMPPARQNRPRWEYGDPAVKGRNPGRYEEIDANNEIPHRTCSQCRDAEQQVMYGSAMSVSLPPVPSNYEEAMASPEADKWIAAIKAELDAMARHQVLIDLDLPSGARALGSKWVFTRKENAQGEVTRYKARLVAQGFAQRPGIDYNETFAPVARPSTILSLVGTAAAQGLFLEQFDFDSAFLNGTMTEMVYMKYPKGWDRPQTGQALRLVKSMYGTKQAPREWNAAVNSLMVECGYKRSDADSCLYVKRVDEKFIYITLYVDNGMVASNDQEFLDSEIEAFNKVYKLKRLGPVKLFLGLEFERTSDYIFVHQSKYIRDLVAMYGGGSVSKHPVKVPMEPRSDVEHSTDPFDDVALYQSAVGALQYAAHRARPDIVTSVRAAASKVSAPTQADWIAVKCIIRYLQGTVDWGLKFNHGGSTVFELYSDASWGDDMSTGKSIGAFVSILAGAAISWQSKQQSMVATSTTEAEILAASAAAKEAMWLRRLAADLELEQPKATLIWEDNQAVIAIALNPAHHGRTKHYNVHHFYIRERVTAGDIRIKYCKTGAITADILTKPLARNLFELHREGMGMVGAGARVLCGGPAEAAGCLHEIASFWPSCFSLFSTTHSISHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LTD3</accession>
    <name>A0A2X0LTD3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C010g05918 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C010g05918</name>
        <name evidence="2" type="ORF">BQ5605_C010G05918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY13627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LTD3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY13627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="58" mass="6120" checksum="2843FE50E8247DA6" modified="2018-09-12" version="1">MARLVETTPPSPRTGPLILPSSNHAYQNVVQRLRHDLYDSTGFDGTAGGKDAVGPSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LTX2</accession>
    <name>A0A2X0LTX2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C011g06580 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C011g06580</name>
        <name evidence="8" type="ORF">BQ5605_C011G06580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LTX2"/>
    <dbReference type="STRING" id="796604.A0A2X0LTX2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF48">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G01000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY12688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="418" mass="45807" checksum="FFA276F1BCC1A9F3" modified="2018-09-12" version="1">MTGKYDFNILLSAVYAAFVFCEIPSNYLCKVIGPAIFIPALSLGFGAFSLAMAFVMTFKSGIAIRFMLGIFEAGVFPGIAYYLSRWYRKDELGFRLALYIVFAPLAGAFGGLFAAALLMIPKFGMVTSWRMIFFIEGLMTMTVAIIAFFLLSDRPDTAKWLTPEEKALCAARSKSENVGAAVVVDELKTQVFLSCMFNTTSIVVAVIFLLTNLTVHSLSFFLPAIVKTIFLTMSVIHLELMTVPVYVVGAIMSLLLPYLSWKTGRRALWMTLSAPLMIVGYSIFVATNNPSARYVGCFFIASGTFALISFSNTWSAINTTSDTARAGAIAMTVFGGNLGGVAATWSFLPQYAPHQLPGNALNLGTSTVLLVLTLGLWAWQNRQNELREQGSLNYLLEGKTREEVAAMGTKHPGFRFRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LUP6</accession>
    <name>A0A2X0LUP6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C017g08330 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C017g08330</name>
        <name evidence="1" type="ORF">BQ5605_C017G08330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY19817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LUP6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY19817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="115" mass="12607" checksum="AF6DD4107D915719" modified="2018-09-12" version="1">MDAQIERAFDVPKDAFDGLEMRCPRFSNKLREIPHSVCKIGSGGNNGVHEGADHRTIRRVVGFIGVDLGQQLEVGLHWRFAGIAIGHAETSQHVDKVLALQEGDPAIIMPDDLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LV93</accession>
    <name>A0A2X0LV93_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C013g07380 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C013g07380</name>
        <name evidence="2" type="ORF">BQ5605_C013G07380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LV93"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY15484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="69" mass="7816" checksum="A70993343C853C79" modified="2018-09-12" version="1">MKSWLHSGDIRGRHGRNLQGGSQLMEGHVRFRLSGRATPSEQAQLKSDPVQRFNQHSDIPMPACAQRYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LVJ8</accession>
    <name>A0A2X0LVJ8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C013g07099</name>
        <name evidence="12" type="ORF">BQ5605_C013G07099</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY14773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LVJ8"/>
    <dbReference type="STRING" id="796604.A0A2X0LVJ8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045016">
        <property type="term" value="P:mitochondrial magnesium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12823">
        <property type="entry name" value="Mrs2_Mfm1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039204">
        <property type="entry name" value="MRS2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890:SF0">
        <property type="entry name" value="MAGNESIUM TRANSPORTER MRS2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890">
        <property type="entry name" value="RNA SPLICING PROTEIN MRS2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22099">
        <property type="entry name" value="MRS2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="57"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY14773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="544" mass="60335" checksum="322AA3E4BCDB9D0F" modified="2018-09-12" version="1">MQARRMSASRGLLASVSQRSCTCGFSATTTTSSSMVAPVSKSYFSSIFLRDNARRRLTTGGMTGPSPRDHYGPPVPRSWTRSSSSLPSYLHRPPPQPHSTPAYEVKKLEKQAAKSSLFSWGRGPSSTAPPHHPSDEDPVGALKEREMEKILLRRRMRRESGKSFSRGSTTALDVRCTTLDENGVVTTTAGEYDKLQLCSRYGIPPRDLRKLDSGVPTVVPTILVRRSAILLTILHLRVVITAKEVTLFDSVGTEDSHLKSVFVWDLEYALKNPSKAGPGTGHHSALPYEFRALETCLISVTTALDTELDNIRALVQELLQALEEHIDRDNLRLLLQYSRKLADFEKRATLVMQCLDEVLENDDDLAAMYLTEKLRDNSRLSNDHEEVELLLESFSKQCEEIVSEVEILSANVRSTEDIIELILDSNRNSLLGLDLRVSIATLGLTSGTLVAGLFGMNLQSRLEEHAYAFPIVTVGAMILAVGVTYLGLKTLRRMRRVGLGWRGAGTGSSLGGFARDRNPHGANEPALRWGDKWASRKRSKFRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LYG7</accession>
    <name>A0A2X0LYG7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C017g08365</name>
        <name evidence="4" type="ORF">BQ5605_C017G08365</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY19880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LYG7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="544"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY19880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="956" mass="107296" checksum="FCF3E3D919C40BBE" modified="2018-09-12" version="1">MTCNPAWPEIINALLPGQTASNRPDIVARVFQGKLTACLHGIYGDHGRPGVFGRVTQTLSIIQVVAHVHVIKFQKRGLPHAHILLILHPDDKPKTNEDFDQIVTVEIPDREKFLTLFETITNSMLHCQCNLPGQHTCHDKNGKCSKGFPKQFQDRTTSEDGGYPHYRRRNLHQFIKFPGTGREEIYTNANVVPTNPWMASKYSCHINVEIANGVAAVKYLYKYVYKGHDRTLFTVEAGPPRNKVKDFLDARYVCAPEAMHRLFQYQMHGQKPAVTRLALHLPNEQQVRFDPEDGPPTTAAPPETTLTAFVKLCATVPPVPKTQNLLYIDVPRSFRWDLNNRAWQERKRNTPAIGRMYFCGPEAGERYYLRLLLLNVPSPTSFAQLRTFNGTEFKTFREACVKRGLLRDNTEANRCLTEAAVFHSGHQLRHLCAMLLTADGGVSNAAELWETHHNSLSDDAEYHLRMRRGQSFITPEHISSWALLQLDQILQRLGTSLCDHGLPLPTATFENELELSRLMMEERSTPEEIERMNREWMKNLEAYTVEQRHAFDTICDSVFNVRGKTFFINAPGGTGKTFLETTILSRIRSENKYALAVASAGIAALLLPKGRTAHSRFKIPIDIFDDSTCNVHKQGQLAELFRACELIVWDEAPMQHRRHFELVNKMLQDVRTSLARFGGITVLLAGDPRQCLPVVPKASPTQILDACIMNADFWGEVQILHLGLSTKTNMRLLAAVHRMTETELAKSQEFADWLLKVGDGSANIDGGDSITLPDHLCLPVDSRHKTGLINHVYPLSADDLTLMSTENKVAYFRDRAILAPKNADVDELNNMIIKRLPGGSIILTGDHAGQTILLPRITLKNASSADLPLTLYRTQFPIRLAMAMTINKSQGQSSGHVGVCLENSVFSHGQLYVALSRASNVHGVKVLLPTTTGTQQHASHNVTDNIVFTRIFDSMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M009</accession>
    <name>A0A2X0M009_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">triacylglycerol lipase</fullName>
            <ecNumber evidence="2">3.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C019g08896</name>
        <name evidence="8" type="synonym">BQ5605_C019g08902</name>
        <name evidence="7" type="ORF">BQ5605_C019G08896</name>
        <name evidence="8" type="ORF">BQ5605_C019G08902</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="2"/>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY23100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000019">
        <property type="protein sequence ID" value="SGY23128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M009"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF1">
        <property type="entry name" value="LIPASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036522520" description="triacylglycerol lipase" evidence="6">
        <location>
            <begin position="27"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR029171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY23100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY23128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="421" mass="44675" checksum="C143C8B643F2BE06" modified="2018-09-12" version="1">MMDLHRSTILRAATGILALCASLTSAALPAPDSDPFYVPPSTFANDAPGTVYRTRLALNPGVGVTGTQILFRTTDALGKPASTVTTILQSARASPKYLVSYNMYEDGAAAKCAPSYCFNTSPFQLFCPDGDLQLTQILLRGWTTIVTDFLGTTSAFSVGHQSGYQILDGYRAAINFLRLPKDVILGGYGYSGGAIGTGWSAALHNSYAPELNIKALAFGGTPANMATTLNKLNGGAFAVSIARNGFAVAGLAGQLSAFPELQARFDKVGTAKGKAAIASARNECGASDIIRFAFTNILSTSFQSIGKGLLSDEMVARYLALSDMKANVTETPTKPSIYMFHSKTDEVIPYSSAHETAQTWCGRGSKILFTTEIGGGGHVGTQVVYGERVFNWLDAQLRGTSPALRTCSFVNKFTLTVPVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M0A3</accession>
    <name>A0A2X0M0A3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g01925 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g01925</name>
        <name evidence="2" type="ORF">BQ5605_C003G01925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY37950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0M0A3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="675"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="799"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="880"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1105"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1212"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1283"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="451"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="703"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="719"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="804"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="951"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="962"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1222"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1298"/>
            <end position="1319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY37950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1410" mass="147478" checksum="76BC01ED41BCBAAB" modified="2018-09-12" version="1">MLGTLPNYVSSISGDDALQQPSRSPSSASFSVSPSASSGNENGGGRVHSHGHASTSPPEIPDRSHRRAASISKRTSYSRSRGSSSHLQPSTSALCAPPEAPSTSRRMPKSAVYNDLASTARGSSSDPPQSSYSTASSQISTTPLAHQPDSPLTPTMASQTLPSGASGASHRDRNRTPFATPDRSIYANPSASTDISAISRSREASVSSDSSLKTGTTPKPLHKPPILMPSSILETAGSRSHLSYPTVHSSGLSGVSECYDDKSDTDSAGSYGWSGLDDPTLQHEPTKSPLFGEEASGSGYTNSVLMGGVTTARLRTPSPPASRSGMRRIRSISKSDAVDGDPAAWWTSPGSGKRLSLMSLKATDLEAVRTETPAAVSEEIENGQALNSFGIAYIPTENINSGARLSAYEPQRPSSARSRATTPDYVREQSPSRPSGSAAVPEQAAVRVQNSSPLSDPSLAPPFVEGPQVTTRQQPLSSNRSVERPALLGPKSSSSGSDELVTPPKSPNRQPSPSLQRDASSQSLSESVGVLSLASPTTSTMVYTSPQVGGSPSSQAIFAERKAKRQVSAPAPRPQKSRHRASASLVGKHKFHHETKTLAPMSTQSDAETASSSSGQVFELGAAERIAARRTLTMLSPAESRFSRGHLDEPPMSASDFAMSYGEFDAVTPIGNHEVDQDEEPLTRTSHVRSPAVADEPIDMDVAPSSPSQPTAATPRLATVTTTASSKRPPTRSEASKDGIQNPTSLYSQLTNTIADAANLEHDLSLVEVGGAAAGPTSSEREPLRSASRLQVIDRPGSVAGLSDVNSARASSPGFSSEDVFHDATAEDGMMSNVRRSSSGSDLSTVPAPASITPLGLGGVKLDAKARAAAFVADLKRARTAASESSNGEPPVPSSPLMASPMTTPVMTSEPLGITVSSTSPTTYVEPESPREVLILEGHSDSGPSQRLDAKPSSPARASPASGPPSFSPDTPRPLTPQVFVGEESLSSQSAFPPAQPLSPIFRAISISDRTPLAPSTIAGLPAPYDSPPLAAPEPPPPCPPRLMLRRRRPLPPSLQIINDLQRTRTAGERANLYAMKIRELRKETSGMATWVSFIQHGVHERMSAQTVSQLPRHSRDEGSSASFPTRADATCARELPPGSFTRQDLVPTVPFPGVLGAIHHSPSSSLPGISSLPSSSSSTARFSTSQLLSSTSLSMRPASTIKDKASFFTSLGRRGSRRESASAAVPTSSTSVTPPPRRLSVSAPFNAGPTTTTTTTTALTSAVLFSSVRAAGVVAGPRPIGGASSLHPGPNGGITTSSAPIPVSAASPIPSISSNVASKTSHESLNGTTKRTSFINVGGQSAVSEAMDARTELLGEEREEEDDEETKEKIQRLVDILPYARPEQIRSALRRANGDDVLAISIFLSDDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M204</accession>
    <name>A0A2X0M204_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C001g00013 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C001g00013</name>
        <name evidence="7" type="ORF">BQ5605_C001G00013</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY43312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M204"/>
    <dbReference type="STRING" id="796604.A0A2X0M204"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18004">
        <property type="entry name" value="DEXHc_RAD54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="521"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="900"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="18"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="463"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY43312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1217" mass="132694" checksum="5B5F553DF81B9AE3" modified="2018-09-12" version="1">MPLLQRSSSASYYPTYQSVARSPVASTSTSRLVHRDEQDHGASASMSVTVGVEKGKGRAVEEITIGGSGSGSGSGIGDGRPVVQRVNKVEVWTVQWREPQHRKNKTWERDGFLIIKGPSATLRDENGKTLGSTTLSMPIEPELELKVGGRECKIDDTITYAEYVRQFHDSSTVVSAHPSAGSPWISRAPMPGAITPGGGTPRALSRPTPSKPSGLASVMTATKLPVADQSARAREAIPMGMGMMSISSSVIGVKRHTSRENEDPIRAVDNDEGTGGYESDLKRIRREDETQPGRRIDATRVIDRTNVDGPRLMATPPAAQEPVKKTGKEYLCQYRKYSTKTNPTWEGDGILIVTGTSGSLKNRETRKTITNGAIGPKVRLDPEQQINMGGYTLEIESESTAAPTATLPIVAPSVRPPPVRNMASMKPPARPPPSIFDPIAVAASIPSSNFYIPGVTPRASKAFQDPTHGMGSAGSKGKPELGPQPRFDPTKAGAVVMRRPDEEHELVYNGKGVKFMYEAVMGMRGEGQGCILADEMGLGKSVQAISLIWTLLSESEFESRPVSHMGFRPERGLDFTEQNPYWGSGTGVIQRAMIVCPVTLVKNWSREIRLWLGYDLLRPFIADSGANIKSFCATKSYNLLIIGYERVSRLRTVIDDIKAVQPPIGLIICDEGVLYTPQDVLGPLDPDTGPSSPSGHRLKSSDAKISKALRSLSCKRRVILSGTPIQNDLQEYHSMVDFVNPGLLDSYSVFKKHFENAIIKSREPGASAKDKKVGEDRSKQLTRIGTAFLLRRAGDVIAKCLPPKLEYTVFIAPTPLEISIYEEILVGSAARALQEGSITEQLSLLMVLRQLCNTPGLLMQSIEQNKKVDALKKPVVELLWKAGNDSYDFALSGKLLALGTLLHQLRSIQGEKIVVVSNFVQTLNIIERHCRQKRYPFSRLDGNTPQAERIALVEAFNRGKNTTSFVFLLSSKAGGTGLNITGASRLVLIDSDWNPSTDQQAMARIHREGQKKQCVIYRFLTAGTIDEKIFQRQVTKMGLSTSLMDDDQSGGAGKADSFTPDDLRSIFKLHQGVACQTHDLLGCKCHLDLDHDDDGEGAARMEANLGPTSEDASSSLQAFEPPGFTQASQFHALGGGFDLEIVQRDESRRLGMLNNWAHYNCCDEASVDEIEDTLLRSVVYQRIIEAADGTEGSVPEGRATYRLRGGQVGFVFGKKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M370</accession>
    <name>A0A2X0M370_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00370 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00370</name>
        <name evidence="2" type="ORF">BQ5605_C001G00370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY46010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M370"/>
    <dbReference type="STRING" id="796604.A0A2X0M370"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY46010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="440" mass="48911" checksum="6A0DD2021E631C55" modified="2018-09-12" version="1">MTTMQPILALRHVYEPAVQLCRTDSVVSAMANSTLGSPHHHLRKGECAGLESRSNPSSPTFSQGKLLQGSDSEAKAFRENARSYNNALSFTSLAAHWDQTQVGTLGPPVFHVFGRLYHRLGALIPAVNQCPAFAQTWLINPAEATDTRLEPDGADSHMQRSTLTKLESMLRTKNHFVREFASAKARAGWDTAKEWILRLCLRPGRDQRTYNLPTCTVIDVPRVGPSTKSSARSIRLRCLSGSHYYFLQGKMASTPTFLFAGFAKLGCQSPETESRSTMVSNRARYLRVSVLMTEAKRRTKTATMRMKTARKGTKRMVMANDEGQVKGSRWRVSRSPFFAHYLPNATSTSQSRIAPNVPSWTIPGCDGVRCQTWKASAAHHDDVRPRFTGNQGCTGADKACNRPDLIARVFEAKSGNKRHAGCFGDECKMNRFCFFAVLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M3L8</accession>
    <name>A0A2X0M3L8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01600 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01600</name>
        <name evidence="2" type="ORF">BQ5605_C002G01600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY34231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M3L8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY34231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="111" mass="13110" checksum="9BF34496D9D18170" modified="2018-09-12" version="1">MTEPHRASSIVDATRRASSRSDVGHLPHSRPNIEVTTDFRQWYILSGRGKVSTKRRSLQMRAINMRLITSFSDIRKSDMRREQECPRSSVRLLCHCYLRRRMQCLDHHCLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M5A8</accession>
    <name>A0A2X0M5A8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g02202 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C003g02202</name>
        <name evidence="1" type="ORF">BQ5605_C003G02202</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M5A8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY39339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="220" mass="25271" checksum="4E6B80F56FDE9075" modified="2018-09-12" version="1">MCLSEAPECLVHLAVGCPFARRLWSALSPTPHPVFVDFVYPVVSRSERRLVKLRVLFFHSIWKLCRRRRFSSDLLEPITETEFEGLRASIQESKGRLVSLQGSSSIVDASRRASSRIDVGHLPHSRHDIEVTTDFRQWNILSGRGEVSRRSSEMRAINMRLITRECSVWPIIVFNEAHSHRSLLHTGDSKSRLTRHRSNQFHLGPQGSCIVFLVSVMRSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M5F0</accession>
    <name>A0A2X0M5F0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C003g02242 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C003g02242</name>
        <name evidence="3" type="ORF">BQ5605_C003G02242</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M5F0"/>
    <dbReference type="STRING" id="796604.A0A2X0M5F0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47369">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47369:SF1">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="315"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="781"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="968"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1105"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="546"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="968"/>
            <end position="977"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY39592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1220" mass="131640" checksum="363C1E936972A575" modified="2018-09-12" version="1">MASCSVIRPEEVASDKYVQFQDLDRLIGSTAMDVESSSPESATTDDLSRPQLQAQARAPSRSSFPSSGPFGTLQATPLYHLRGDAMVQAEPVRIHAQRPSGSAEMITSSSPGCKSGSPSSYSPPSSPSYRRFGSALRHAVESRAFNDLLDTSSIGQTINSPLIGVLPHTPLTRIETAQSYEGGAALSRPATAPAGGQDDTTHGVAFASSSCSEVPPQQAAGESSSRYLHDFPLPGGNSLKSRKYRNPATPSGSSSPSGSRESRGRSHSSAQASARYVPLLRPPPLRPHASASPTPSMQSLQNHMYTYGLLNGTLSDLHLVAFGHHYRLHRIVLAGQSGFFTSLLSGGFSEERQGADRGSDSEVIAVEMDRPLSRAAFEFVLARLYGGGPELVPPPWAKTSAKKPLSETWERLVLIATGRMDIDPQTSLDRDYLLDLSGGAAETDSEWSTIMAPTCQPATPTFLLSLLATATYLEIPALQSLALHWIQKTITPWTVAQYLGFALGRGLGSGSLSPELDAPCRGLESVGAPYKLDDPSLSPMTETEYSSTRSSRASSISSHLQDKETACSGDAVSMFVGPEGERIGEACACWLAKWGAETLTTEEWLAARVVEMDSKAGAIMDREDVLSLRCKIVEPFFYDEKRPACFETHPELAPPSLAIWSSIGGIDARWVRGVISSDAFFIANTISSATTKLTGDFAPEGLESDGEFQRYLFAKRVIEMRRGEKLDALNRSNRSRLGASGHGRNSKWDGLADGISERLGLLDLQQSVVDHSSFNEDQTYAMATTGDGPTTDAKCPGEGPSIGVSSSSQAAASSARIDLSSVDELEYALLFQDGIHYYHMLMARSLGYFAQTYRQLNLISDDYSMTSHVLFAPIEVVQRAHWQIEQFKSRLPLVHTPRSGQALEMAGLLSSSRVGGGVPVGRMPLPGELVTLDGLVDIGFATPVNPHLDVNMPALGLQPFYRIPIDDTSRINDRAPHPDSTPSALGLGAPSPIPPRKPSSPLSYGPDGFFGLAREQRLGTRGGPHRGVLPGLSLDLSSEWVEYPPLRLSAEFWGVTALRDNARLYSNTFFYAGSFYNLYLQRLQRKGGNQLGIYLHRQNSIEHFPTPSTPPTRLAHGPPYSEASASRSASYSTAILAPYTDQRKQVRAFFSIWVPTQLGSSMTKFSSGPDSFALSQSWGWKSTSLSSEYLGATPIEASQTEVAKAGPYSSLRVTIIMGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M5H1</accession>
    <name>A0A2X0M5H1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arylsulfatase</fullName>
            <shortName evidence="2">AS</shortName>
            <ecNumber evidence="2">3.1.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Aryl-sulfate sulphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C003g02363</name>
        <name evidence="7" type="ORF">BQ5605_C003G02363</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>an aryl sulfate + H2O = a phenol + sulfate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17261"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:33853"/>
            <dbReference type="ChEBI" id="CHEBI:140317"/>
            <dbReference type="EC" id="3.1.6.1"/>
        </reaction>
    </comment>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="2"/>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY40377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M5H1"/>
    <dbReference type="STRING" id="796604.A0A2X0M5H1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005539">
        <property type="term" value="F:glycosaminoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008449">
        <property type="term" value="F:N-acetylglucosamine-6-sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018958">
        <property type="term" value="P:phenol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16147">
        <property type="entry name" value="G6S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012083">
        <property type="entry name" value="Arylsulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108:SF8">
        <property type="entry name" value="SD21168P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000972">
        <property type="entry name" value="Arylsulf_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015899878" description="Arylsulfatase" evidence="5">
        <location>
            <begin position="23"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="6">
        <location>
            <begin position="50"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000972-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY40377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="621" mass="69470" checksum="E7117481A7056917" modified="2018-09-12" version="1">MRGTYTSLLALLLVVLLPVARTDPQSSRGPAATGQVQGPQDDSTRSKDKPNIVLIIVDDQDAVQDSISTMKAVQRLLVQEGTSFERFFAPVSLCCPSRTSFLRAQAAHNTNVTSVIPPWGGWGVFSEKGYNSHYLPSFLQSAGYSTRYVGKLMNGHNVKNYEKLAPAGFTDADFLLDPQTYNYVNASFGRVGSPVQYHAGSYSTDLVKEKALNLIRDASHQGNPFFVGIAPIAPHSHIVSLSHDFGPVRLQAPESAPRHAHLFKDVTLNYSRASHNPSFPSGASWVRQLERLNQTHVEYIEEFYRQRLRSLQAVDELVEAVVDELEKNNKLDDTIIIYTSDNGFEANGGHRRNPGKTLPYEEDIRVPLVARGPGVPKGVVDSKSVYSLADLGATIMHLAGAKSDYEHDGSLVPLTQELRQMVEREGIKQYHLAEYWVDGIEEGIYAGQSERSAHTVVLGKLNYPDNVSAGKSFLNTTYRAIRIVEGNSIDLSYAVWCTGEHEIYDLRTDPDQMHNLAEVQSQSSELQKLLIRLDALLLVLKTCVGEVCKRPWNEMFPQNNIRSLKDALDVKYDEYFRQLPKVTYSRCELGYFSELEHPFWSSDLAFPPQGFHRLSMQATEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M5Z8</accession>
    <name>A0A2X0M5Z8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g02553 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C003g02553</name>
        <name evidence="1" type="ORF">BQ5605_C003G02553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY41779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M5Z8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY41779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="156" mass="17830" checksum="9FC41C706D8B03D5" modified="2018-09-12" version="1">MYDVTPTRKRQHTQGHASSPTCLFCGNDAAVIETVSHYFFECAYSTSFWGGVLRILFDKLGIEDTDVDPSTFTPEQLTMGLPLLRGRGRTTSKWMWVRLACAIGFQRLHLLRWRVHQRFELDKVVAPPPLPSALRAFERDFLSRAGFVPGARDWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M602</accession>
    <name>A0A2X0M602_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C006g04109 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C006g04109</name>
        <name evidence="3" type="ORF">BQ5605_C006G04109</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY56130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M602"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015921569" evidence="2">
        <location>
            <begin position="25"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY56130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="133" mass="14703" checksum="02D02DD4A69B002C" modified="2018-09-12" version="1">MCGCCLANGLFAVSSLLLSHRCTGTEEVSLVQAGGARAHAQDNSQAFPRKREGADRKFLLGKVRSLGLSHLQPIYDAIEQAPTAKPTPKRQKRKAVSPVGAQKHQNLVGREESREYIFDRMDDEARPNFLNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M8V0</accession>
    <name>A0A2X0M8V0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g03753 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g03753</name>
        <name evidence="2" type="ORF">BQ5605_C006G03753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY53381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M8V0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY53381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="453" mass="50123" checksum="A4D17F6622623104" modified="2018-09-12" version="1">MRTRIASSVRRDEGGAPPMFSASRTPRAAIALSDITNNLVDTKPDLSASKKKVPAGAHQRAPSNKAKPSKAAAATASDAKPVKPVEPVKLLKLEKPEKSSGVDAVAEDDDSLHASTHSSDGDLHEAGHRLDALTTSDNESEEDKSPLGSDSGGPETESDHLQRPLKKASSKRQRNDTPDDLSDCSEDNLPLTEALSIFSTALATARSDLHKLIGRVQRKEVDMLRAMQSWYKDNPTTYTDEHLAWWSVLVSHRIAELRSSLRAYTSRASIDPQRLVEQTDVERGFADSKREFWLHLSGFATTLATTLAKKAAQRFYHARYCPNGAFDYSIFLYRTVVSQFYDADTSPMTTRPKVSTMDSTFQAQCTTVITTCQPVADFQRLVLCKETGRESLQMTARQWQNWMVEGTTLRCGRHAKPVVWEAESHVPRCFDGKWNLDEGRRSGLADAETALAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M984</accession>
    <name>A0A2X0M984_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C004g02913 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C004g02913</name>
        <name evidence="2" type="ORF">BQ5605_C004G02913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY68720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M984"/>
    <dbReference type="STRING" id="796604.A0A2X0M984"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025255">
        <property type="entry name" value="DUF4202"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41729">
        <property type="entry name" value="GLUTAMYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41729:SF1">
        <property type="entry name" value="GLUTAMYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13875">
        <property type="entry name" value="DUF4202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016164805" evidence="1">
        <location>
            <begin position="23"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY68720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="98" mass="10789" checksum="6AA61A67231897CE" modified="2018-09-12" version="1">MPAPTTSARLIKVLCLLSEAHSTDPCSESSTYHSTLSSYVTRLCRDAGNEEPSEALVIAANAQHVRRWDKPRNEYSMGLSGYKMWRVSAVRCGRGQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MBH6</accession>
    <name>A0A2X0MBH6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C007g04554 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C007g04554</name>
        <name evidence="2" type="ORF">BQ5605_C007G04554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY61385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MBH6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY61385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="287" mass="30471" checksum="FA87D2272F82673D" modified="2018-09-12" version="1">MSGSLESRTKLGSYQLPTKSIPDLGSARQGVRERTTTMVSLRLNNSPRVPSFAGPIALAAGLLSVICFSEPIWQNFFILKCDTQNVTMKAGAWGVCTKLRNSTGIVGPIEWCTSKKSGYSLNFVTNSSGVNNWPTFLQNPNVSTPTPIDENVLLGLAGNGGVTVLTSGQTSLMWLQVVTAISVVSTVASLACPPSYLGSPQSRLFAFQKSGILPILLALITFVLAVVTFFVTLSVSMSGRNRLNAIGGGVNAGLGNTIWFTLASSIVMIPAICSVLMRSSPNEYQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MCM4</accession>
    <name>A0A2X0MCM4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C007g04875 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C007g04875</name>
        <name evidence="1" type="ORF">BQ5605_C007G04875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY64152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MCM4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY64152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="57" mass="6213" checksum="EB5FE082381C6BF0" modified="2018-09-12" version="1">MYSASVDDVATRLWIRELQEIGPSAIVTNEISRGIALLAHVISPGFSPVARDYVLIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MCX0</accession>
    <name>A0A2X0MCX0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C004g02777 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C004g02777</name>
        <name evidence="7" type="ORF">BQ5605_C004G02777</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl coenzyme A hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY67461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MCX0"/>
    <dbReference type="STRING" id="796604.A0A2X0MCX0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03442">
        <property type="entry name" value="BFIT_BACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655:SF0">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="6">
        <location>
            <begin position="152"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="HotDog ACOT-type" evidence="6">
        <location>
            <begin position="366"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="82"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY67461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="510" mass="56666" checksum="650E8CD5C6B10311" modified="2018-09-12" version="1">MLGRRQIAHFARTSTSKATTVSSLHRALTLLSRASSTSSSSSSISPSPLSSEVNSFNPKQEGGSVSRIARLLEWSDHLARTNKSQGNASVPHRLRGASSSRNRGPDDKVGRSPRPRVAPFVRLTLSKYPAMLQLKRIPPDQLKPLPTTRRVQDSYVQLDLKFSEDPVLRESYLGGLSKQPRMSRLMEDFDSVAGAAAYRYVLPDGVTVSEAESYGLYLVTAAVDRMDVLKPLTQLHDGSVPDLRLSGHVSYASESSLEVFVRLSTIPQKPEEESATILIGRFAMACRKYSGGKQPIAQLVVVGEQEEELVKMGKDMRENKKRRKAMSLETTPPSAAEAKMLHDLFVGKQEIFARNASCPDDVVFMADTALKSATLNHPTEANVHNKIFGGYLMRLAYETAFATACLFSRSTVHFIALDEIRFALPVEIGTHKSFHVSVEAATTDFFTGERRVTNTFHFTFASDRPLARHVLPKTYLDAISWLDAQRRREEGIAVRKAYDSEEVYRTGRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MD24</accession>
    <name>A0A2X0MD24_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C004g03099 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C004g03099</name>
        <name evidence="2" type="ORF">BQ5605_C004G03099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY70073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MD24"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY70073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="333" mass="37081" checksum="1DA829FDAAEAB532" modified="2018-09-12" version="1">MTLCFPKQTETTCLACLPHRIVVPSTIQFLPLPNSHLQAFTSRLLYNNLHGEQQGIRDVGSCSHVRHATTKKHLDAYNSRADPAVNWTNRLLQPTPQALSSSDEADLVDFNQNPAEAGTVGHSLLAVAGEIIKSSESVPASRPSPPSDHEDSVLDHALFLPKGNCSPYSQGTGSKSDSEVEIDGGAEEEESDDWAPPRCGRNYTSAPDSSHPWYPFPSQNLMIIVVFFRSHKRRVGVQELDDMLAFAKAFGVQGPPAASSVKKFLANLEKEIPLFKPRQYTKEDLRTLPTRGVASRLHRCARRRIKDALEWMKRVEKKCVVDEFTSARLKKHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MDX0</accession>
    <name>A0A2X0MDX0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="4">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C009g05604</name>
        <name evidence="14" type="ORF">BQ5605_C009G05604</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="4"/>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY82924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MDX0"/>
    <dbReference type="STRING" id="796604.A0A2X0MDX0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000001">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF32">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="13">
        <location>
            <begin position="39"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGY82924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="180" mass="19493" checksum="0CBAF5A9E18B7985" modified="2018-09-12" version="1">MASSNSALKIFSGKCQPFALLRRRRNALLTLTAANGRRTGTSHPELAQLICRRLGLPLGNSSIVTLPSGELSVTFHESVREADVYIVATASSDETGTNGALMELCIMAHTLRIASARRITAVVPHFPYARQDKKDKSRAPITAKLVANMLVRGAGIDHVITMDLHASQIQGFFDIPVDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-11-27" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0ME35</accession>
    <name>A0A2X0ME35_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C004g03038</name>
        <name evidence="9" type="ORF">BQ5605_C004G03038</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Vacuole membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ATG22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY69601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0ME35"/>
    <dbReference type="STRING" id="796604.A0A2X0ME35"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF5">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY69601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="204" mass="23501" checksum="A17C9D108260AC1B" modified="2018-09-12" version="1">MLYFTFYFLFNDVLATGVTVISTLQYATVDFDTITLNWLLLVGIVAQGAGVYIFWRIQKFWQVSIPRMFHYVVVVWGMIGNWTTKFGYHDKWEFWLYQVVYGLGGSTWYSYSQTMISEFTPVGHEFLFFSLFTISGKSSSFIGPFVTSAISNRTNNVSASFYFLFALGIVACGVLPFLDVERSHRDCAAFIEAEKQELEVHKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MF39</accession>
    <name>A0A2X0MF39_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C038g11696 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C038g11696</name>
        <name evidence="2" type="ORF">BQ5605_C038G11696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000061">
        <property type="protein sequence ID" value="SGY91776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MF39"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY91776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="524" mass="56953" checksum="0BCE72297DE2B3F9" modified="2018-09-12" version="1">MSPNGGAECATTSVDPSVPTIRHVRSAKVPVDPVDPVNPNVPVANIVIIVTIKVIEALKDRINHVDDHALLNDIIVPRLALCSASDLVEQVFQTDPLRFRQMSQRARTSGKKARSGQDEDAQEELHARFKEVHDRRPAATTAASTGQSTWMHGVARHAHTGHPRRRQFKLGMAVAERPARVHVHTDHAPESEIGTEPKSSKEAQEWTHFLACPDVDSSSMNLLWSRVLVACAFGASPRADRPRDSQGGSAPHLVRVVLDLVEHVLAQPTRLFAPGLAVNDEEAHLAVLDHETCRIATIPDCWGQGSGVRVFGSSVGRTVKFEDEEPIELVSCAKTDGGRPLSERCTTVFHVIRPSLSSSGTASTASRRSPSFVLKMQLVSPSFVGVESGVLRKINDAYDTGALSPDVYDHLATLEARAALSAPACEPIDEDRLPSSASTACGDGATELEKAAPSPPAEQAQRTLELLILRNPTPLPRPLVRRHREEQDLPLAQVVHVLVRLLTVLTALHDLSFYHRDLSLGNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHC5</accession>
    <name>A0A2X0MHC5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C032g11045 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C032g11045</name>
        <name evidence="2" type="ORF">BQ5605_C032G11045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000067">
        <property type="protein sequence ID" value="SGZ04142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHC5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ04142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="57" mass="6131" checksum="3B768B6DCA3547D3" modified="2018-09-12" version="1">MSRARGGDGMRISRKAAERRGVKPEAEGHVPGCFDGKWNLGERGRNGLSPRGLSPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHN6</accession>
    <name>A0A2X0MHN6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C009g05803</name>
        <name evidence="12" type="ORF">BQ5605_C009G05803</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="FQNC01000049">
        <property type="protein sequence ID" value="SGY86162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHN6"/>
    <dbReference type="STRING" id="796604.A0A2X0MHN6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF15">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="144"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="374"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="23"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="231"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="522"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY86162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="575" mass="63812" checksum="2348E3B34E1FD0F4" modified="2018-09-12" version="1">MDAFKILAAGTRFDRRRFNQDIQAFEPKSQTPRVASTSTALPSELDFFGNVTAPPESTETASKKRKKSKSNHHQQQQQQQQPPEALDYATLLRTKRIKCTGDDVPNPIPSWNHLPQNAQTTLLHNNWTTKMRLHEPTGIQMSAWAIMLENRDLLACAPTGSGKTLSFLVPLLLSVTPSTSDDPSTKKGPIAPRAIILEPTRELAMQVQREALALSQGSRWKIRVLGEDGFGDGQKPVKKNKKRSKAEQKGGKERSETTEKGAEEAELLLEEKQEEEGGVVEILISTPLRLIYSIKSSQVSVVGTSHLILDESDKLFELNFLTQTDEIISHLPSTTQKAMFSATLPSSIEELAKTVMKPSLIRAIVGHKDAANDQIDQTLLFVGAEDHKLLSLRTLIAQGQFTPPVLIFVQSILRAKELATELVLDGINVDTIHAERTAAERDAAVQAFAQGKVWCLIATDVLGRGVDFRGVKLVINYDFPQSAGSYADAPYLKIIVNVMRSSGCAVPSYMLDLKAPSQDDKKRLRLKPVGRKDISRTNGSGNKDARDRKRKKRQRIMGGEEGVFKKRKEKIQIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MI96</accession>
    <name>A0A2X0MI96_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C018g08592 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C018g08592</name>
        <name evidence="3" type="ORF">BQ5605_C018G08592</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY25221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MI96"/>
    <dbReference type="STRING" id="796604.A0A2X0MI96"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06869">
        <property type="entry name" value="PX_UP2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047168">
        <property type="entry name" value="LEC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024554">
        <property type="entry name" value="LEC1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024555">
        <property type="entry name" value="PX-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47185">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN YPR097W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47185:SF1">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN YPR097W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12825">
        <property type="entry name" value="DUF3818"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12828">
        <property type="entry name" value="PXB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="288"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="917"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="918"/>
            <end position="936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY25221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1013" mass="113520" checksum="A2978DBF65726EB9" modified="2018-09-12" version="1">MAASNNPYKQYVPTSKSASPAPVAAAAHPLSPSTPTSNPYFAAANNLNTTSTRQPTLIRTSSFISELGIYSPSVTNSIEAPSHNPMALTPLRAHYLKRELVTLGFASELEAFGSPSAVSLLGHPFLPESRFKNGVPLPEPKPGSMEALSLKNKTEEETVDLPFLRFVFHQFVLTFPFLAKCPPTFFSHKLQPFVYSFVSRNISGSDERAEVTSRRKVQNKIEKHLGLIMSAAIKLVENDGKEEVVRIEDDGSMQTAVPASQAPKFGTPSKANKAQASVKPPPEAAFSINIVSVRNSVVKGRVRNKTHEEFIIRTRQKGHKDVYVARRYGDFVRLADTLRIECIEQDVASPPNKDRRKTELKPGGGGGTPPSNNSPRQSIDESSSAHMSAPVNLRNMPSLARERNRLTLRAYLRSLLNNPVLAATGAFQSFLVESPIDLTSMEMRDVELREEMDRIREEEARSFRSEVDERVAELEAYLRTFREHLVQSDGLSRVFATIRRTEKVENLPVEYRKVLEWARISLASTIYQLFLGSDNSSSIFMQLKRIHGMMPYFMLRGILKISNPIAMVRAVLDLFLARPFGSSSLLQKMFSSGLNDEVRELKDDATLVAHKIDDEVLCDKVEGFVDASKEYQDRCRAEAKAENVDLMSVILHSDQEPRMDATTFERVQRASVAYEEYKHERDQLTDPDEDEGPDNDDAWLFEDLHVLLRILTKARDKEQLIELIFEGSTSELLKDIVTIFYEPLAKVYKAANIADSLSDLQTFLNDLIKTVEFAEDANLTDPQQTVQIFVDLVGRHEARFYHFVHQVHSKGEGLFDSLMKYIELFINFVRDGLPSAISLEALLPAGGSQERQAMMAEVDSIVAYHHQLKKAHHDRLRKRMLKGKETEADADAAFVTGVMENLHLGGMMGDVADVTAEASDEEDFEEGGNATSEDEDEPRRPIELALAPPPRSNNPYKTAMLERIPIKNPGKRKRRPIQPPELKLVPALVPIFVEMVRPELQAARRKTKAALGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIE4</accession>
    <name>A0A2X0MIE4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C037g11572 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C037g11572</name>
        <name evidence="7" type="ORF">BQ5605_C037G11572</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000062">
        <property type="protein sequence ID" value="SGY93091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIE4"/>
    <dbReference type="STRING" id="796604.A0A2X0MIE4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031332">
        <property type="term" value="C:RNAi effector complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00175">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000018">
        <property type="entry name" value="Serine/threonine-protein kinase 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000001">
        <property type="entry name" value="Staphylococcal nuclease domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016685">
        <property type="entry name" value="Silence_cplx_Nase-comp_TudorSN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302">
        <property type="entry name" value="EBNA2 BINDING PROTEIN P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302:SF2">
        <property type="entry name" value="STAPHYLOCOCCAL NUCLEASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017179">
        <property type="entry name" value="RISC-Tudor-SN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TNase-like" evidence="6">
        <location>
            <begin position="57"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="6">
        <location>
            <begin position="196"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="6">
        <location>
            <begin position="381"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="6">
        <location>
            <begin position="549"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="5">
        <location>
            <begin position="760"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR017179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY93091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="942" mass="102182" checksum="6EC18221534AF2AC" modified="2018-09-12" version="1">MAVTASMSATIARVTSGPPSLTSQSAAFLPSVQLVLRGKVLSPNSLPRERVVHLDDGLTAPRVGNRDREDEPWAFDAREYLRALLVGKTVNFQITRTISTTTPPLEFARVFFTQPDGEQLDVGLAVVKAGWAKLRDSPKGAADGDEDPRRAEFVQAEEEAKVMARGMWATNGPPEQHVNFSMPEDPSTFLAQYKGQPLDAIIEAVPNGSTVRARLLLSPTHHQVVGVGLAGVRAPRAGNLSSADSSAPSGEEFGDEARFFVETRLLQRMIKITLLSLPTPAVAPSAFNSSGPAATPAPATMFIGTVAHPAGNIAALLIATGLARIVDWHAGFLSQSPTPGMMAELRKAEVEAKGARRGVWKFLPAATPTAAAQAAQQEKERKFEGVVTRVWGADMLSVVKTGETKERRIQLASVRQPKPNDPKVGGLQAEGKELMRKKLIGKSVNVNIDYIKPAEGDYEARECATIRVAGGANVAEILVEKGLLHVIRHRQGDEQRSSDYDKLLAAEAKAVAETKGVHSGKEYPVGRIIDASESAQKAAPFLSSFKRQGRAAGVVDYVAAGSRFKVFIPKQDIKLTLVLSGIRAPRTARNASEKSEPFGAEAAQFAGRKCMQKDVEVLIESADKSGGFIGKMFLGKDDFAVLLVKEGLARVDEYAAEKGAKDLVEAQDEAKRNKKGIWSNYDAAADAADAAAASSEPAVARREYVDVVVSDVRGSADSPFSFAVQVLSSNSSIPELERLMSELTVFHEETSGDLTPANFLPRNNDLVSAKFSQDDVWYRARIRRANPAKKEAEVLYVDYGNSETIPYSRLRPLAAQFKSLESQAKDATLSFVTLLDHSTEYGLEAQDRFRDLCEGRQLVANVDARDPGLLHLSLFDPNDPESAKGHEASINVQLVREGYARVDQKSRFRQAYPQVVKALERATEQAKRDRAGAYELGDIFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MIT9</accession>
    <name>A0A2X0MIT9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C036g11524 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C036g11524</name>
        <name evidence="2" type="ORF">BQ5605_C036G11524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000063">
        <property type="protein sequence ID" value="SGY95883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MIT9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY95883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="354" mass="39144" checksum="818DC80B0218CC20" modified="2018-09-12" version="1">MALSLSCSETEGSSPYWGNGNSAPRLNFGARTAGRCAESSTNLEARDTLQRLDVLDHSGRAMSTGSGEDWYGSQVPDRNKRSIQAPSTLLHDGSSEHGLATSRKRWGLTREKAMDRELNRIHRPLHSRQRPGLDGQIGARRATLANAVNPRCLGDLLCREPTVPILLTKVTPFHCLPPMLQHTQLFRRTTPWIDVSALPRMHDHNDLSTRSRYSEEEAPQFVTELHHIKSPTHDHWRDFIWLPQEQTHLHPAAFASADRKQWDEAFSPDSLPGFDAPSRSVSAPLPGHFFSTSAESTRHGGLGQATQAHDHGQLFSAHLPALPSSAMGCAAGIELDPEEPEPFSLAALQHDLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJP1</accession>
    <name>A0A2X0MJP1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C020g09072 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C020g09072</name>
        <name evidence="10" type="ORF">BQ5605_C020G09072</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000082">
        <property type="protein sequence ID" value="SGZ16843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJP1"/>
    <dbReference type="STRING" id="796604.A0A2X0MJP1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="564"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="595"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="46"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="274"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="332"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="425"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="640"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="425"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="451"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="649"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="701"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGZ16843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="750" mass="82238" checksum="C94220D790A6267C" modified="2018-09-12" version="1">MSIVSSTVNATVAFSPPNSCGDLQNDRSVQIAPASIELVPHNQHLKEYTFPSPSGGPQATRSEADLEQDQLRSPTPEPLQSPHRHPSPSTAMGGVVLSSEHVAAVSDKEKFAESDLPRFPQYDLTSEHPSRDLPDGLQQPRSMSFSGLTPILSHSPSLRQQEVPTPEQRGLPPLPPLSETRPSSRHEYSARDQHSGRDQGDHRSSTVGRSYPILGSNDYATPEPHPYTPRQYNLEGGTSGNHLRNLLLHNHSQSIPHPQQPAQVVYGSSITHESYTIPSMPHPAQQHPMGMYPGQQHQYQHGNGSGSSSAGMSPRTPTAHVALGAHHAMENEAPFYPSGYPQRQHSAEGSADGLDPSTMQYGGHPYFQQHPPPAYHDHGSDQHRPGFSGPMYYSDNAQHVHHQQHPSQQHPQHHQQHELRYLGPREDMNHGRDDGQTDHQEQGQQSSGGRSSRRPARRTMVRRAAAVRQSSNVYHPTPRSMLAPNAPSLPWSGIPGVAASAPPGKLAGIPTDDEFMQLPTKRSRGRRPPSSPELLFPSNPNIDPNEALIAYSGVTKTGKPRKIFLCKVPDCNKIFKRSEHLKRHVRSIHTEIKPFQCQWPGCAKLFSRHDNLNQHLRVHRAPGQSDASFSIQLEHFFGNREGQQDPHQSTSRGVASTSAVAGASAGSGSGSSTAALNLPPLQGSSPTLRHHHHQQQQVQQSDHRQEYDQGGHHSGDEYDLDENGAPIPRGARESTAGSLETEGSLYAPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKD1</accession>
    <name>A0A2X0MKD1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C033g11154 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C033g11154</name>
        <name evidence="5" type="ORF">BQ5605_C033G11154</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000066">
        <property type="protein sequence ID" value="SGZ01574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MKD1"/>
    <dbReference type="STRING" id="796604.A0A2X0MKD1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12280:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit B 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01356">
        <property type="entry name" value="NDH1_NuoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005012">
        <property type="entry name" value="PRK06411.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56770">
        <property type="entry name" value="HydA/Nqo6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01150">
        <property type="entry name" value="COMPLEX1_20K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase-like 20kDa subunit" evidence="4">
        <location>
            <begin position="113"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGZ01574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="238" mass="26203" checksum="6849DF5BD437A51C" modified="2018-09-12" version="1">MNAFRTGLVTLRSSGVHAVAPTRIAPALLQHYRTISSSSTNPIHRSSPIARATSQTPATVDASNAFKLAKQGSNQLSLETPKNGVEYALATADKIVNWARQGSMWPMTFGLACCAVEMMHMAAARYDQDRLGVVFRASPRQSDIMIVAGTLTNKMAPALRKVYDQMPEPRWVISMGSCANGGGYYHYSYSVVRGCDRIVPVDLYVPGCPPTAEALLYGMLQLQRKMRRGRKGVTWYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKR5</accession>
    <name>A0A2X0MKR5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C022g09471 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C022g09471</name>
        <name evidence="5" type="ORF">BQ5605_C022G09471</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MKR5"/>
    <dbReference type="STRING" id="796604.A0A2X0MKR5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="353"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="4">
        <location>
            <begin position="7"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="300"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGZ22303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="374" mass="39520" checksum="58F1BF5D8D55F6F0" modified="2018-09-12" version="1">MATRTSTGVKRILKEASELEADDSCDYSAGPLEDDLFNWHFTIKGPSGTDFEGGVYHGRMILPSEYPFKPPEIYMATPSGRFETNKKICLSISSFHPETWQPSWGIRTALLALMAFFETEVNLGDSGEHDLYIDDCQRFMFVVQAAGAVGSLEVPPAERRRLAQASRTFHCATCDFHATKFLTLTTTTPSSDTEDGEAVDEEDEEDEEVAAVASSTDRSDEATAIFPSSRGPGVCAADVGGHAVTTPDHVSGTADRVANASAPHPRHHHIPTAAATLDAIPAPQLRVVQHRPAPGHEPRSAAPSPSNATSASSVAAVASTSSAPAAAAAPPAATPETAALPADLMMIGGQPTAVDRLILVVLVAILALVVRKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0ML02</accession>
    <name>A0A2X0ML02_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C022g09564 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C022g09564</name>
        <name evidence="1" type="ORF">BQ5605_C022G09564</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0ML02"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ22946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="136" mass="15391" checksum="3E076A3D984FA440" modified="2018-09-12" version="1">MSSTAAPPDTRIQLFLDDLTVGELLAFKFTRPDLTATLAVSEFEPTFHPHQIRPNSSTRALFNKTHDPRELYATGYRSIEVRSPCTSIVEHMPIGSEAFWQHLDSVEQLKSMTNATPRTSSWQAPCLLHFEPPYCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0ML05</accession>
    <name>A0A2X0ML05_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C032g11040</name>
        <name evidence="12" type="ORF">BQ5605_C032G11040</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="FQNC01000067">
        <property type="protein sequence ID" value="SGZ04041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0ML05"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000063">
        <property type="entry name" value="Zinc knuckle domaincontaining protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045358">
        <property type="entry name" value="Ty3_capsid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19259">
        <property type="entry name" value="Ty3_capsid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ty3 transposon capsid-like protein" evidence="11">
        <location>
            <begin position="139"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase RNase H-like" evidence="10">
        <location>
            <begin position="923"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="330"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1032"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="47"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="360"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1037"/>
            <end position="1050"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF19259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGZ04041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1100" mass="123955" checksum="F43D6B40FCABB580" modified="2018-09-12" version="1">MTSCNVYSYKNNYINPASRPIILAIACCLRLSNLNPDSRSKFPIDLVDLTQASLDSLIDQLRTLQARNQALEAECRSHLSDKENYQITVTALANQQQTLSDFAKAVIDQQKESIDVIKSGLANLNVTAPANTTITPVKSQLAKPDKYDGKEKVKFKTFITQIKFYIFGNPSYFPTDESKIAFIISHLTGDAFQHFEHAINAKDNSKPEWLTNYQKFLDQAELVLGDPDYRNNLTRQLMSLVQSGPASVYASKFTQISSQLDWNQAALIAHFHKGLKLDLQAQLALHNDPQDLQSLIELAIKVDNKLHLARHRTNASTQFRQTNWQYSHSVNSPLRTSPVSQLQANPSTANTSGPAPMDLDATRSRRGPLSEEEKLRRRTNRLCMWCASDQHLRAQCPTAPPMIPRHTALNASLRMSCTGTLFPQVLSPPSPRYSQQNSTRFPKTTFFCPSYSISSPHPDLATSFVHDNHLQLIAHPTPIPLYVIDGRPIQSGNITHFVHLEVQFNGHTQSLCADVTQLGTYPLVLGMPWLRLHNPIIDWKRNTLVYSCQSCALGHTQPINVSIEGAPLVPLDHKHLDISFASSFAFERLVNNSDNHHGLLFYDPASHQLSSSSPAPSQSLSDNNQDSLEYLKPLKNLVPPEYHHLLAAFSKVKADQLLPHRKFDLSIDLKDNTTPPFGPLYPLSETELQTLSSWLKENLSKNFIRASTSPAGAPVLFVRKKDGLLRLCVDYRGLNKITRKNCYPLPLIPEALDRIRGAKIYTKLDLRSGYNLVRIKEGANERPHFERAMDTSSALSCPSEVLQHFINNKLYCNPKKCEFNRASTEYLGFIISPSGVSMSQDKVKAITSWPTPTSLKELQQFLGFCNFYRRFIEGYSRVIAPLTRLLKKNTPFLLDLAALSFLDRLKQIFTSGAILCHFNPLLPSIIKTDASDFAISGILSQVTDGHLRPVAFMSRKMLPAKQNYEIHDKELLAIVECIKIWRHYLEGSQHPFKIYTDHAALQYFQTKRVLTRRQARWSETVNHHKYTIEYRSGSKNNKADTLSRRPDFSEGGKASEQPGQILLRPHTLAASLVKFSPPSDIADLIKFHLSQDPVLNLASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MLY4</accession>
    <name>A0A2X0MLY4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C024g09885 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C024g09885</name>
        <name evidence="7" type="ORF">BQ5605_C024G09885</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ26317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MLY4"/>
    <dbReference type="STRING" id="796604.A0A2X0MLY4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF42">
        <property type="entry name" value="UPF0057 MEMBRANE PROTEIN ZK632.10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01309">
        <property type="entry name" value="UPF0057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGZ26317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="121" mass="12872" checksum="5CD7C8F75B5861E1" modified="2018-09-12" version="1">MTSGHRGCASLVSRACSGFKASTGDGPRRCSSLLPALTLVPLTRCTPPSLQVTSHQSLCPNNSSAMPFTASDICKIILAIFLPPLGVFLERGCNADFWINVILTILGYIPGIVHALYIILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MN49</accession>
    <name>A0A2X0MN49_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="2 10">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BQ5605_C021g09409</name>
        <name evidence="13" type="ORF">BQ5605_C021G09409</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8 10">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + [thioredoxin]-disulfide + H2O = a ribonucleoside 5'-diphosphate + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="2 10"/>
    <dbReference type="EMBL" id="FQNC01000083">
        <property type="protein sequence ID" value="SGZ21725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MN49"/>
    <dbReference type="STRING" id="796604.A0A2X0MN49"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005971">
        <property type="term" value="C:ribonucleoside-diphosphate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01679">
        <property type="entry name" value="RNR_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573:SF6">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51998">
        <property type="entry name" value="PFL-like glycyl radical enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="R1 subunit of ribonucleotide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="12">
        <location>
            <begin position="2"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="737"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="737"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="788"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="846"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SGZ21725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="856" mass="94627" checksum="2EF96C7FA7B8DB91" modified="2018-09-12" version="1">MAYVYKRDGRRELVAFDKITARISKLCYGLDLNHLEPIEITKRVIAGVYQGVTTVELDNLAAETAAAMTTRHPDYAILAARIAISNLHKETRKTFSHVIEDLYTYINPKNGRPSSMISQETYEVIMANADRLNSAVIYDRDFGYNYFGFKNARTLLLASHRRQGRRTPRNTCSCSYNLMSERYFTHASPTLFNAGTPHPQLSSCFLVTMKDDSIEGIYDTLKTCALISKTAGGIGLSIHNIRATGSYIAGTNGYSNGIVPMLRVYNNTARYVDQGGNKRPGAFAIYLEPWHADVFEFLDLRKNHGKEEVRARDLFFALWIPDLFMERVEAAGDWPLFCPAEAPGLHEVYGEEFRALFEKYEKEGRAKKTIPAQKLWYAILEAQVETGNPFMLYKDAANKKSNQKNLGTIKSSNLCTEIIEYSAPDECAVCNLASIALPSFIKDGVYDFKKLHEVVKVVAFNLNRIIDVNYYPVIEAQNSNFRHRPIGIGVQGLADAFMALAMPFDSPEARKLNKQIFETIYHAAIESSCDMARDFAIANPGDPGYYSTYPGSPASQGELQYDLWGVTRAICGTGPSSRRRLQSTILGFNECFEPYTSNIYTRRVLAGEFQIVNPWLLRDLVNRGLWDEGMKNTIIAHNGSIQNVPGIPSDLKAIYKTVWELSQKTIIDLSADRGAFIDQSQSLNIHLSSPTMAQLTSMHFYGWKRGLKTGMYYLRTRAAVGAIKFTVDQDTLNKAKAANKQQPAVTAAAAPTPSPIRSPAATPSNAMREITNGASKVSLATPVKRETPASPSSPSSVSSPATMVPIPALSTSAPLGAAAPSASGPTAASNKDEPKARFRTRRRSAAAKPRSSSKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNC1</accession>
    <name>A0A2X0MNC1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C027g10358 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C027g10358</name>
        <name evidence="2" type="ORF">BQ5605_C027G10358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MNC1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ28511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="72" mass="8285" checksum="EC117DA8F2EDC17C" modified="2018-09-12" version="1">MACDPEWPEIKAALWPDDKACNRPDLIARVFEAKLNRRDNDVFGNKQRAGCLGDEWRTVSLLYFVVCVLKLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNE4</accession>
    <name>A0A2X0MNE4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">D-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="9">1.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C014g07479</name>
        <name evidence="14" type="ORF">BQ5605_C014G07479</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="9"/>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY18809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MNE4"/>
    <dbReference type="STRING" id="796604.A0A2X0MNE4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF111">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="13">
        <location>
            <begin position="157"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="29"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGY18809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="608" mass="65366" checksum="8EDA72AD71EA8E03" modified="2018-09-12" version="1">MQVIRRPPSRALVISPRLAVQARWASNNLNNGGRAHPLSRPSIPTRGGPTSTTWSSSTFAARTSKQRVTALTTVLLATLTGTISYLLGLKAQGPANRSTGSGLSSSCKEPTRRDFDAAVKELQALLPEDSLGLDRDSLVARSHSDWACESLGRRNLMFGLPGAILYPRNTQDVVNIVKLANKYSIPLIPMAANTSLEGHTGALTYMSNPSDAASIAKRGRGERITLQDLEPGLAWVVDVSENMNEIIKIHEHDLQIVVQPGISYDAINETLAEKNIPLFFPVDPAPGAMIGGTGASGTNAVRHGTMRENVYNLTVVLADGSVIKTRSRAKKSSAGPNLTQLFIGSEGTLGIVTEATLRLVPKLPQRVGVSGFPTIEDAANAARDLVQQGVGLACIELLDDVMIKMINAKGGGITWDEKPSLFLKFEGTQAQMAEDVERTKKIVKNNHGSKFTFSRNDKEAENIWYSRKMGLYAVIDHVPGSKVIVTDVCVPPSQFPALVAATKADISTQGLIGPFLSHAGDGNFHALLSWTTQEEKERGYGVVARMVERAQALDGTCTGEHGVGMGKIKYLEAELGPGTVDILKKIKHILDPKGIFNPGKLIKDEPCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-11-27" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MNJ4</accession>
    <name>A0A2X0MNJ4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C022g09550 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C022g09550</name>
        <name evidence="5" type="ORF">BQ5605_C022G09550</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000084">
        <property type="protein sequence ID" value="SGZ22841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MNJ4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015892998" evidence="3">
        <location>
            <begin position="21"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="124"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="359"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGZ22841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="447" mass="48940" checksum="A5E278823CC09BD3" modified="2018-09-12" version="1">MRVPSALFALLPLLGQLTQAHHDAAPRHHQPRSFKLEVRTPQRSDLLRLDGTMNVELVKRAVKQHHQRRQAQAVAATRNQTAHLNVLKRAQETEDMFHAKKARVMGRALKTGAVPVKPHADGSWSGTVGLGPGGSQKILNLMLDTDGPRLDIFAKGSPTKCNTTYDPTKSPHAIKGASFTSRDGIARGDYYQDSVTFGGLEVANQFFRVFTNTSNGMSLEDHLLLLDEACGFLGLGFNTIQPTLVQTLISSHAIARPFFAVALNNKGGSVDIGTVDTRAYKGHVAWAPLAYGAKSTSWTIKTPAFTKDKQPVANSSNLTVSFQTYFSFTMIPPWFGHQLFDDIGGSVDKENFNFYRVRCDEIKKRTFGFIIGGQTMEVPLSSINIGPYDNDTSKCSLAIIPAPDTLDEITFGTLALESFYVVYAFARQNMGPAVGVAEAKTVPHPPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPE2</accession>
    <name>A0A2X0MPE2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00002 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00002</name>
        <name evidence="2" type="ORF">BQ5605_C001G00002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY43216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MPE2"/>
    <dbReference type="STRING" id="796604.A0A2X0MPE2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025340">
        <property type="entry name" value="DUF4246"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049192">
        <property type="entry name" value="DUF4246_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119">
        <property type="entry name" value="IFI3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14033">
        <property type="entry name" value="DUF4246"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4246" evidence="1">
        <location>
            <begin position="120"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4246" evidence="1">
        <location>
            <begin position="256"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY43216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="543" mass="62048" checksum="B4A23E41C5ED2C22" modified="2018-09-12" version="1">MEGPSKKTTPLAKIFPSPFSFQGSQYSGERPRSSLDRLSYSIRSNKADWQTKRLSREIRTKWAMEALEQSAEKAHMAFKQMTLERQPLTFWMVDYVLEELEQHARMERVVDGQWRLPSSKNVPEEQKDWHPGSKKQVLDLVHPSLYPLVYKQSVVRKSLDGEMQPGTTAASAVTLAEAPAPKPSSTSAIPTGFDDADETSYLSSQYQWLPSNFTLDENGGVSIDGYINNLHPDDHADFSEFDEDKWMENYGSDFEEAIIQDALDEARERWEMSREITLPAPQGVFHPAPEDAIRRKIENPTFTIKGRTVQVIVKLANIVLTPDQPTYTGGVWHVEGMKNESIVATGIYYYDQVNIDGSSLAFRGTFDETELPYEQNDESRVEIVFGIHGDGPTVQSYNSAATTHNRCLTFPNIYQHRVPSFSLRDRTKPGHRKILVFFLVDPLRPRIPSTRDVAPQQREWIERALCESTPGADTEADDSAPSRGSLIDRLPNELWDRILDLTDGLITQDEAKEHRNKLMFERKFKLKEHSTEVYEREFSLCEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQI0</accession>
    <name>A0A2X0MQI0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C026g10186 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C026g10186</name>
        <name evidence="1" type="ORF">BQ5605_C026G10186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ27776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQI0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ27776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="113" mass="12545" checksum="769CBCD393750772" modified="2018-09-12" version="1">MLSSHRRPFGHGECFSRSTKLWNFSMAGVEAIVALMEEKRKKIGVGMGSENSVEKIPFFFSSIKANIALVLVLEELHSFVDSEKALAVYSNGLRSDHGIGRCFGCDHVLRVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQM2</accession>
    <name>A0A2X0MQM2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C043g12096 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C043g12096</name>
        <name evidence="1" type="ORF">BQ5605_C043G12096</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000117">
        <property type="protein sequence ID" value="SGZ32154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQM2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ32154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="93" mass="10917" checksum="A83904F6A93BF3A8" modified="2018-09-12" version="1">MGKIQFDANPFARRLWSALSPTPHPVFVDFVCPVVSRSERRLVELRVLFFHSIWKLCRRRRRFSSDLLEPITETEFEGLRASIQESKGRLVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQN7</accession>
    <name>A0A2X0MQN7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C026g10246 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C026g10246</name>
        <name evidence="2" type="ORF">BQ5605_C026G10246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ28003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQN7"/>
    <dbReference type="STRING" id="796604.A0A2X0MQN7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ28003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="513" mass="57503" checksum="1952B18875AF801F" modified="2018-09-12" version="1">MRSKISDFPGFYLRASGWAFMGPLLPWACTSARSWAPRGSTLLFVPRRSTESAPARVMTTMQPILALRHVYEPAVQLYRTDSVVSAMANSTLGSPHHHLFLRRGKCAGLESRSNPSSPRFDPRQPRPPDGRGKVRLPPPPQPNLEYRQLLEGSDSDAKAFRENARSYNNALSFTSLAAHWDQTQVGTLGPPVFRVFGRLYHRLGALIPAVNQRPAFAQTWLIDPAEATNTRLQGPDSTETRIQRSTLTKLQSMLRTGNRFVREFASAKARAGWDTAKEWVLRLCLPPGRDRRTHNLPTSSTEMAMLICDSDTNTGDRGPQDLILQVHGDRCPDGRPKYQVVSSLHPSVMPLRYPLLFPAGEDGFHPNIPLCGSDQAGPPIARNREQIDNGVQLREVLAGLGLDDEDEQEDEDRDNEDEDGEEGDEEDGDGERQANGSRCQDRLTQHIRLHQDNLRLTTTQGINGLTPNQIATSRSETRMRWPKSGNKRHAGCFGDECRMNVFRFFAVFRIVYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MR27</accession>
    <name>A0A2X0MR27_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C001g00542 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C001g00542</name>
        <name evidence="1" type="ORF">BQ5605_C001G00542</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY47557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MR27"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY47557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="120" mass="13195" checksum="EA2BA4B6133AAAC1" modified="2018-09-12" version="1">MAFTTPIPWQKVRDQVVQCKPTFVGASSYLYDLAPRSLPLASTCFHEFLSLSLGFPATINRASYSYKNNYINPASRPVILAIACCLRLSNLNPDSVVKSIGGSDGEEHIYLPPPLAHKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MR60</accession>
    <name>A0A2X0MR60_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00572 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00572</name>
        <name evidence="2" type="ORF">BQ5605_C001G00572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY47774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MR60"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY47774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="138" mass="15136" checksum="82A5F53940B3A25B" modified="2018-09-12" version="1">MTEAKRRTKTATMRMKTARKGTKRMVMANDKGPVKGSRWRVSRSQFFAHYLPKATSTSQSRIAPTVPSWTIPGCDGVRCQTWKASAAHQDDARPRLTGNQGCTGADKACNCPDHLIARVFEAKSGNKHMQAVSAMNVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MSD6</accession>
    <name>A0A2X0MSD6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C051g12535 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C051g12535</name>
        <name evidence="10" type="ORF">BQ5605_C051G12535</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000096">
        <property type="protein sequence ID" value="SGZ29557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="9">
        <location>
            <begin position="954"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="141"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="776"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="783"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="805"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGZ29557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1574" mass="179413" checksum="C036B7846342B2BD" modified="2018-09-12" version="1">MKTYYITDSKFDAAKLKDILAGHHLKPQGDFESSRKQLFDHQCTKLCLFRGADVIEAGFQTDSIQFLTEGEVAEVAQTLRLGTKGSRSKVNSYCILDIEFAGVKKPQRFEVANVYYDVIIGDDFLRKYDCVVTFNPDEVVSRQPDPIQETPVKKAERAPRPRQKKRQATGHAPIKAQSKLQRNIGEAHDFDQDEWDDDDEVVIHFGSMTTMDDTLTIKTREIRELENRATIPVYPSTGQEDSPDYEPTEEDKNRYKMWLLFTFVKIFIGEGDKLPFPPMRAVMHEIPYIDKSDPPRPRRHYKVADAMMDKWVTLKDQHVEAGLWIPASTKNADPMMPILKKDGKARPVVDLRARNANTVKMSIPAVDADYIRSRIATNKYHVELDLKGAFQQLRIKPSDVWKTAFTSIHGVYTTPVAQQGDTNSPATLARMISYVYQGLLGKQMEAYADNIFVVGNTWKEIRDHTISVLVRSQVHELCFSTSSLKVCPEWVEVLGMDCQFGTIRMSQAHKDAILTIAKPTTKVHLQRFLGSVEWSSRYFPHLAEIVAPLTNLVGDAPWTWSAAQDIAFEETKKAIDDARQLTVIRQEELAPRDTDPIHRSAPPTEPVTNPSPGKYILLQCDASSVGTSACVTYGENWWNALPVYHHSRKLTNTQLSYPTHEIELLAIFEGFQKFHNILLGRKVTVITENESLASFLTARQMNERQARVYNFISQFDFVIRHIESDWNKTPDMFSRQYEDDNICDSYEDPNLDDLDTEHDRDDYLLLGSRLQSLQTETLRRSSRLAQPRQTEQTKTPAVETTPKAKVAKPKPKKLSRKENAIAARLEEEGGIPTDQALNLDPQHRDRTWQAATDYLNDPFFKKIVTTVDDFDRYTLSADGALWQNDEIYGDRLCIAAGTVDGRKVRELVLEHVHEMTVHTGSRKMLAHAAHHYWWPTTSADIEEYCKTCEACQVSKTGPLQTIAVDFQGPLVKAQWNGKEVDFLCNWIDTFTGETISVPCEQTITAKGCAELFFQSVFPHWGIPLQIVSDRDPRWSSDLWRSMFEGLGTTLLLSTSFHPQTNGRIERMHRDLNAMMRQIVNETHTNWPDQLPSSCRTENVPGWARPPDGTAAGELIDRAMQRRSRARDTILKARGDQAVIANRKRKPDAQPQTAIGELFLVRTANFACAPDRPRKWTPPWAGPFKCVAFTPATSTYTLELSPRYAQRRLHPRFHASQVKKWVATDENRFPNRLFNPKPLFPIDGVTMTDNIQTDQQMEVDNRDDIEYGKYGDLIGEDVTSSATQPTPAPAEAVQAAPAPVTETIADEPEQQVTAPIQRSPSPDFDEPSYDKSITVASLKNREEWSEILRLHHRQAPAKSGLGERNPPPRIKNVINISRNGTGLRYHVKYSDNKNERSDTLQTTDDMVRDLWDAYHAGYKTPLNRWLDMHMAVNEITLFEALERKRAELAETGHLNRRQLRDQEVEGKQQRVRHDRSMLDISDEIKESEALLKLEEIRTRTAAAKLATTQLDTERRELLPRSKGKGRSHPSVWVLSLPLRGTHSFEPILKPEYSLQYLFKDNEYDESIGPVLAILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MSX5</accession>
    <name>A0A2X0MSX5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C047g12301 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C047g12301</name>
        <name evidence="7" type="ORF">BQ5605_C047G12301</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PET117 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000113">
        <property type="protein sequence ID" value="SGZ31089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MSX5"/>
    <dbReference type="STRING" id="796604.A0A2X0MSX5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031568">
        <property type="entry name" value="Pet117"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28163">
        <property type="entry name" value="PROTEIN PET117 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28163:SF1">
        <property type="entry name" value="PROTEIN PET117 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15786">
        <property type="entry name" value="PET117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015943657" evidence="6">
        <location>
            <begin position="26"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="68"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGZ31089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="119" mass="13184" checksum="9CB7B26125815C49" modified="2018-09-12" version="1">MSRSSKAFFGLSLVIAVASIGGVHLSQYQERQTMFAGVLRDDARLAAKRQARQAELDEQRRKQAYLETLQTLPSTTSTSSTTTGLGRGDDDGEGRRGVRVMSREEAEGVDWACKECERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MT93</accession>
    <name>A0A2X0MT93_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C006g04148 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C006g04148</name>
        <name evidence="3" type="ORF">BQ5605_C006G04148</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY56583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MT93"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="2">
        <location>
            <begin position="362"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY56583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="474" mass="52818" checksum="2A6F3D9CFCBF403B" modified="2018-09-12" version="1">MAVCIHFKTRHWECERSKSTGHFSTCCSQGKVQLPPPPSPIPSIEIYLKDSGQSSSIPRKRPVAQQRAVFHFDQTRLGTLGLPVFRVFGRRCHRLSALIPAVNQRPAFAQILFIDLAEATDTRLGPDGADSRIQRSTLTKLESMLRTKNHFVREFASAKARAGWDTAKESALRLCLPPGRDRRTHNLSTSSTEMAMLLCDSDTNTGDCGPQDLILQVHGDRCPEGRPNHYYFLQGKMASTPTFLFAGFAKLGCQSPETESRLAKVSNRARYLPVSVLLTKAKRRRKTVTMRMKTAGDEKNGDGERRRPSKGVEVVSLAFTILCALIAKRDEYFSIPHCTQRPFLEFNLRLTTTQGINGLTPNPIGRLMTLGSTFENRPCDITQRYQDAMACVVKHGKPPLLITMTYDPEAPEIKAALGLNDKACTRPDLIAQVFEAKSGNKRHAGCFGDECRMNGFVSLLYFVGCFLNLCAENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MTK8</accession>
    <name>A0A2X0MTK8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C040g11886 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C040g11886</name>
        <name evidence="2" type="ORF">BQ5605_C040G11886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000118">
        <property type="protein sequence ID" value="SGZ32540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MTK8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ32540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="118" mass="12999" checksum="AF0A049CE437A672" modified="2018-09-12" version="1">MGEIDIECVLKKERVNETRALDSIRVQATSESNQYAATPPSASIRRRATRAPTSQCHKSLWTADPLLISHNTNELPRAGELRQLFCFFGPVGGWYRSGAPMPSPPHPTPAQCTSNGHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MWT7</accession>
    <name>A0A2X0MWT7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C004g03092 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C004g03092</name>
        <name evidence="2" type="ORF">BQ5605_C004G03092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY70024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MWT7"/>
    <dbReference type="STRING" id="796604.A0A2X0MWT7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY70024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="452" mass="47337" checksum="BF09FDE5194AFA51" modified="2018-09-12" version="1">MIGAKADECQKLTQGSPRLSLEFAFDADASQLGRSNSTSLALSWAFPSPPSCALAERITNGLFLFSESLPYERDHHSIEQYPTTMTTQCPASPALSPRSQSPETASKPVSAPAAQRNGDQAPPAAAGSPSIDAILRSYALPGNNDVDLLKALLHAKAKEDERLAALDLLRVEQLRAAHTLAMHQAWWMQAQMQQQSAFAAAAAAAAQGKKSPASTFTPVTPPLSGVEAPASWQQLSSRRLSPVPPYSLYPATVCASAGSCREGSVSAQAGPSSEPICKRARAASTASSSSSRSRTSSSSTTSISSVEEDDVALTGPASKKTRRNAPVVKASAVSAPAKKISHEEVMQALRAKCERNLSASKANRPRALAPRPLKPSAVTVLPSVLTAPVSPKTIPMSPVRTTATIAREIKSPSPPLRQSAVFTPADEQIAAGSLRMLIHAANASEPVAVEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MXN4</accession>
    <name>A0A2X0MXN4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate pyruvate transaminase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamic--alanine transaminase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glutamic--pyruvic transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C005g03394</name>
        <name evidence="11" type="ORF">BQ5605_C005G03394</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY75016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MXN4"/>
    <dbReference type="STRING" id="796604.A0A2X0MXN4"/>
    <dbReference type="UniPathway" id="UPA00528">
        <property type="reaction ID" value="UER00586"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042853">
        <property type="term" value="P:L-alanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1970:FF:000001">
        <property type="entry name" value="Alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000012">
        <property type="entry name" value="alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000010">
        <property type="entry name" value="Alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045088">
        <property type="entry name" value="ALAT1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751">
        <property type="entry name" value="ALANINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751:SF29">
        <property type="entry name" value="ALANINE TRANSAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="10">
        <location>
            <begin position="194"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00078532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00080525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY75016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="582" mass="64115" checksum="5921FB22F0B2C66E" modified="2018-09-12" version="1">MRSTSCLNPLVRLSPRSGFVSTKTTSNSRVQSVAPSHLQLGARRFRRSTLSSSSTSLALHLPRLRFSSSASSQFGYSGSSSSSTSFRSFSSTPFTTMVEREPSDRVLTRSSINPAVLKAEYAVRGKIPLRAEELREQLESGDDHKLPFDQVVSCNIGNPQQLDQKPLTYLRQLAALTEYPILIDSPEVSALFPKDVLARAKKLVEEVGSVGAYSQSMGVPAIRKRIAKFIEERDGYPSSPDKIYITAGASGGVSNLLQVLIASTEDGVLIPIPQYPLYTAALALNSARAVPYYLDESNAWSLDMNDVRNNVQKAREDGTVLKAMVVINPGNPTGNCLSRENMNDILKVCYEEKLVLMADEVYQDNIYHKDRPFVSFKKALKDLGAPYSNNVELVSFHSISKGQTGECGRRGGYFELCNFAPEAEEEIYKLASIQLCPSLGGQIGVDVLVCPPKEGEASYAQWIEEREGIAKTLKERSEILHKAFNELEGVECNEAEGALYLFPTVHLPPKAIEAAKKANLAPDAFYCLELLQATGICVVPGSGFGQKEGTFHFRTTFLAPGTDKFAKRLQQFHEGFMKQYRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MZ36</accession>
    <name>A0A2X0MZ36_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C001g00914 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C001g00914</name>
        <name evidence="1" type="ORF">BQ5605_C001G00914</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY50678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MZ36"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY50678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="118" mass="12952" checksum="406C531C3E11AED0" modified="2018-09-12" version="1">MGWGGHWCTRPVPTYNRAKKQKSCLNSPARGSSFGWVNGPADLCPSTSVPQPPALHPLRRTGTWPHLWASPPRRGRHMVWPYSEAALQAVIRYSTMFAVSKSTGALTTIEADHLLAAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N180</accession>
    <name>A0A2X0N180_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C137g13407 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C137g13407</name>
        <name evidence="1" type="ORF">BQ5605_C137G13407</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000053">
        <property type="protein sequence ID" value="SGY88798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N180"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY88798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="87" mass="9590" checksum="5FC4E082C585E7DB" modified="2018-09-12" version="1">MAVLSHSPNATTPETPRFSELQARSTLLSGCSYPPTYYLLCLNLLPTRVRWCCNRTISFAQPAGIGPCLRRGLDRAHTSPTISAVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N1M2</accession>
    <name>A0A2X0N1M2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BQ5605_C007g04611 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C007g04611</name>
        <name evidence="12" type="ORF">BQ5605_C007G04611</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY61849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N1M2"/>
    <dbReference type="STRING" id="796604.A0A2X0N1M2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="173"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="11">
        <location>
            <begin position="318"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY61849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="774" mass="85587" checksum="ACAAC5F39BCBDB43" modified="2018-09-12" version="1">MSSVCYDPTSGAPVPCGGFTVYNSYVTDPEYQRYFTVAWTATLALATLLTLPSVIESLRMGRWRRRSWTGLVLGISERPSSAAYQPIDDRAAEQGSNQPTPRKPSRSFLHGPVAVLSSLYGTVSRFSLGAPLAKRFPRFAFPFGKLVLVLLIPLFYLVTLFPESQLRENPNRFGFLALAGLPPLFLLSSKNGAASWLVGKSWTTVNFLHRWLARTIVLLVLLHFYFWTIQVSQLDPTHLVETTFLTAHHPQYAPSGTAEFLSGSKQRRGIGALSFLLLIAGSSAGPLRRYSYPLFFCLHYLGIIGFLTFVNMHTIYARTWATWSIGLIYAIDIFARILTMRVKHVTVEPLGEGMTKIHIPFAHDGWRGGQHVQLRMFFTAHGRSFWSCFRSLEQHPFSIANASASTTVLQSFSTLGGIDLYLRSCGPTTWTEDLYQTALQAQQISQANPRHLGKKLNLLALIEGPYGGLDAFDPLKQETLLFLAGGSGMSFILGSLDEVIGNRIRTRQGGRIEVVWVVHRFEHVEWFRLPLQALIEAASTSGLDLVVDLQIYVTAPFAVESLDSETPFQKVINARPNLPTLIQSSIDATLTPCRRCYPICRCADLRQDGLCGNDDEECVGSANLRELIVELDREGCGTEKGKKSWCYRVGSGSKENGKMQEEKVVKRDQGSCCSNSNGSPGCCGAGAGAGSAKVQTRVVEGPIKVRQGGYKIIVCGPASMIVSRFYLVSIGKHLLTWIELLFQQVETRQTLSRIPLAKQIKLGGIDLHVEAYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N3W8</accession>
    <name>A0A2X0N3W8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="26">BQ5605_C004g03144 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">BQ5605_C004g03144</name>
        <name evidence="26" type="ORF">BQ5605_C004G03144</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY70361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0229">DNA integration</keyword>
    <keyword evidence="20" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="18" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="21" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="17" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="18" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="19" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="25">
        <location>
            <begin position="601"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="25">
        <location>
            <begin position="2314"/>
            <end position="2481"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="25">
        <location>
            <begin position="3498"/>
            <end position="3674"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="25">
        <location>
            <begin position="4757"/>
            <end position="4896"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="25">
        <location>
            <begin position="5468"/>
            <end position="5644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="859"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1472"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1709"/>
            <end position="1738"/>
        </location>
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        <location>
            <begin position="1764"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="2079"/>
            <end position="2100"/>
        </location>
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        <location>
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        <location>
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            <begin position="2685"/>
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        <location>
            <begin position="5750"/>
            <end position="5816"/>
        </location>
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        <location>
            <begin position="869"/>
            <end position="878"/>
        </location>
    </feature>
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        <location>
            <begin position="2079"/>
            <end position="2088"/>
        </location>
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        <location>
            <begin position="2089"/>
            <end position="2100"/>
        </location>
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            <begin position="2572"/>
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        </location>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="SGY70361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="5881" mass="643230" checksum="BF7221BC5FA3F013" modified="2018-09-12" version="1">[encoded data, 5881 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N517</accession>
    <name>A0A2X0N517_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C029g10605 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C029g10605</name>
        <name evidence="3" type="ORF">BQ5605_C029G10605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000081">
        <property type="protein sequence ID" value="SGZ14599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="796604.A0A2X0N517"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041320">
        <property type="entry name" value="CxC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18802">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxC1-like cysteine cluster associated with KDZ transposases" evidence="2">
        <location>
            <begin position="16"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ14599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="480" mass="54341" checksum="D6128A3653D766A2" modified="2018-09-12" version="1">MPPKRRYKSKPSVYKLQVTFCASESRCATDVERLAQLGFISSTASMPMTAFSFRLVEQAHASWKVSPRAITGYADGLKEYYSRCGWGRGHYTGHPWTFGSNAIDEYRALETCEEDSGDLLAGTVDSFQQVSRQTREKNSNHDQIVPDTFLGEEEVQAMKAEVEASVRPTKKVSNAAFCICLNGIAYLYTHPPSSYYALAILKHISERLPENAKIGVLYDIACNFKHHIEKTKCAYFLIICHQRQLLPKLFKRLEFATSVFHAYAHIWSCQVEFNLCLIPNFGLTDGEGFGEEKARIGAEVRQALAWIEDEKTRSTSFQTLWNNMSDTVRESIDPADAESIFGTEDVEEIRDRALIILDRRMELLQLRECSWSQNDHSFNVWLDTRGQSEGDSEPMRPALSEFRGLHQRLNATGRIVEKAKHHQLPAHNRSGTRVPMETSDLDSARPAPLARDVQQVRVIQAQMDMSDETQLAKEAGPFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N6U5</accession>
    <name>A0A2X0N6U5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BQ5605_C022g09463 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C022g09463</name>
        <name evidence="12" type="ORF">BQ5605_C022G09463</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
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        </lineage>
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                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine.</text>
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        </reaction>
    </comment>
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        <text evidence="2">Belongs to the FPG family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="796604.A0A2X0N6U5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008534">
        <property type="term" value="F:oxidized purine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="entry name" value="MutM-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="FPG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="H2TH_FPG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22993">
        <property type="entry name" value="FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22993:SF9">
        <property type="entry name" value="FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="N-terminal domain of MutM-like DNA repair proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formamidopyrimidine-DNA glycosylase catalytic" evidence="11">
        <location>
            <begin position="2"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="301"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGZ22263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="392" mass="43460" checksum="5DD4BF84515B07DE" modified="2018-09-12" version="1">MPELPEVERARRRLERLAVGRKIVSVIALEDTIVFGGTTAAAFATACQGRVVQEVRRKGKNFYLILDAPITPIFHFGMSGTSVVRGESGPVYRAPRAKTDPNVWPPKYAKACFKFDDGSEWAFCDSRRFGRIKLIEGVAEEQEPLVSLGADPFLAMPSVEVLAEALRKRNAPVKAVLLDQNGPLCGIGNWMIDEILYQAKLVAITDRSLHLLERQELIRLHSEIVNVTNTACAVDAESRQFPSHWLFGARWSKGKSGGKTFVLPNGETTTVTYITVGGRTSAVISSVQKLPPGLLQKFKKESTVKEGKRKAKDDDEGEEEGEEEEPVPREDEDDAPGSLKGELQEELITSPHFKRSRKVAVKSAAPPKRKLDPDPMPAKRPRRSARTSNEHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N7G8</accession>
    <name>A0A2X0N7G8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C023g09685 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C023g09685</name>
        <name evidence="8" type="ORF">BQ5605_C023G09685</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ24027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N7G8"/>
    <dbReference type="STRING" id="796604.A0A2X0N7G8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="514"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="53"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="569"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGZ24027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="596" mass="64550" checksum="6AED6583381341F8" modified="2018-09-12" version="1">MAEPVPHALPVVTYKRAFDRISPWSAVVECRTPISYWPARGPRIQIVANLISVVFACGTALFSDGYQNGIVGSVNTILRRLYPKEFPGNYSTLFSAMGFAGTVLGMLSFGFLVDRTGRKGGMMLAAVIVAVAACLQTGAYGAKGSHKGMFNALIAYRFISGIGIGGEYPAGSVGASENTEDPSIKKGTQHMLFALATNCAIDAAFVVSAFVPLVLLWIAGENHLRVVWRLCFAIGIIPPVLVLFWRLRMAEPARYQVASMKHAPTPYWLTIKRYWKSFLGLSIAWFVYDFIAYPFGIYSSTIVDIITGGSDSLKTIFAWNIVINAFYMPGCIIGAMTVDKIKPKRQMIIGLVLQAVTGFAMSAAFGPLQKHGESCSSPAASERLLIVSVTLARTVAGFAVIYGIFLSFSEFGPGDCLGACRDFQILHTQVPGSSWSRLVRGLAGLLASKSWPTAVRGRFYGIAAAIGKIGAFAGTYAFPKIIASFPAGDKQASGPFWVGSGLGPFDFGMTVQMYILLTLFTLCLIHTAIFSAICVLFLVPEIHADHMTNEDEAFRVYLEANGYDTSRMGLSEEERRTQVSSSSVASIDDTFTDTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N8Z6</accession>
    <name>A0A2X0N8Z6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">1,4-alpha-glucan-branching enzyme</fullName>
            <ecNumber evidence="4">2.4.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glycogen-branching enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C036g11499</name>
        <name evidence="12" type="ORF">BQ5605_C036G11499</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Glycogen-branching enzyme participates in the glycogen biosynthetic process along with glycogenin and glycogen synthase. Generates alpha-1,6-glucosidic branches from alpha-1,4-linked glucose chains, to increase solubility of the glycogen polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="4"/>
    <dbReference type="EMBL" id="FQNC01000063">
        <property type="protein sequence ID" value="SGY95505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N8Z6"/>
    <dbReference type="STRING" id="796604.A0A2X0N8Z6"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11321">
        <property type="entry name" value="AmyAc_bac_euk_BE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02854">
        <property type="entry name" value="E_set_GBE_euk_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000338">
        <property type="entry name" value="1,4-alpha-glucan branching enzyme, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000250">
        <property type="entry name" value="1,4-alpha-glucan-branching enzyme, chloroplastic/amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000003">
        <property type="entry name" value="1,4-alpha-glucan-branching enzyme, chloroplastic/amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651:SF3">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="11">
        <location>
            <begin position="195"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGY95505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="742" mass="84583" checksum="B222AA4579F0C276" modified="2018-09-12" version="1">MRCSTDVTTASLQPFEGSVRHRYTVYKQWVQQIDSTEGGLDRFSQGYRHFGFNVTAQNDIVYREWAPNATSAYLVGDFNGWDRDSHPMMKNDYGVFELTLQAVKGQAAIPHNSKISMTAPGIEGRIERLPAWVKRVVQDLMVSPVYDAVFWNPPKKYQFKNKRPPQPRAVRVYEAHVGISTPDPRIGTYNEFTRNVLPRIAKLGYNTIQLMCVCRAIADRAPALWLTHICPHPDRAIMEHAYYASFGYQITSFFAASSRYGMSNASSFGRGQNDGADHARNCHTTSGTPEQLMELIDTAHGMGITVLLDVVHSHASNNVLDGLNNFDGSDHHYFHGGPKGRHELWDSRLFNYGSHEVLRFLLSNLRFWMEEYQFDGFRFDGVTSMMYTHHGIGTGFSGGYHEYFGENVDTEAVVYMMLANDLIHGLYPSSITIAEDVSGMPALCRTPRDGGIGFDYRLAMAVPDMWIKLLKDGPGDDGWDMGNICFTLTNRRHGEKSICYAESHDQALVGDKTLAFWLMDKEMYTNMSDLTELTVTVDRGLALHKMIRLVTHALGGEGYLNFEGNEFGHPEWLDFPRAGNNDSYQYARRQFNLTEDPLLRYRYLNSFDAAMNHLEESYQWLSSPQAYISLKNESDKVIVFERGNLLFVFNFHPTNSFTDYRLGTDWPGKYAVVLSSDDKEFGGHGRIDKSVEHFTTPMEWNGRRNSVQVSTRWKTNETFRVLTISHAHQLYLPSRTVQVLKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N919</accession>
    <name>A0A2X0N919_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="10">dUTPase</shortName>
            <ecNumber evidence="10">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C026g10199</name>
        <name evidence="12" type="ORF">BQ5605_C026G10199</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="2">This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>dUTP + H2O = dUMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the dUTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="10"/>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ27825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N919"/>
    <dbReference type="STRING" id="796604.A0A2X0N919"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.40.10:FF:000004">
        <property type="entry name" value="Deoxyuridine triphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001862">
        <property type="entry name" value="PRK00601.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241:SF0">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="dUTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase-like" evidence="11">
        <location>
            <begin position="27"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGZ27825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="167" mass="17364" checksum="7BD2B4DF1E740A24" modified="2018-09-12" version="1">MSSSAAATSTKRVLASTSFLVQRNSSKAKLPTRGSTAAAGYDLYSAEAKTVPARGKALINTELSIAVPEGTYGRIAPRSGLASQFMIDTGAGVIDGDYRGMVHVLLFNLSDKDYEVVEGDRVAQLILEQIVTPEVTEVESLSETVRGAGGFGSTGGFTDVAAEKNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NBM6</accession>
    <name>A0A2X0NBM6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C028g10576 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C028g10576</name>
        <name evidence="3" type="ORF">BQ5605_C028G10576</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000080">
        <property type="protein sequence ID" value="SGZ13556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0NBM6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF405">
        <property type="entry name" value="ARF GUANINE NUCLEOTIDE EXCHANGE FACTOR SYT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="2">
        <location>
            <begin position="1103"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="666"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="718"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="846"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="928"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1497"/>
            <end position="1523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="582"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="682"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="775"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="953"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1511"/>
            <end position="1521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ13556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1666" mass="179338" checksum="117F6706C96F29C5" modified="2018-09-12" version="1">MDSSTPYRLPDRQLGSSLPPSGTSPAMSSGSSAQPSPSSPPTSSRSAAIARLRRAASTRESPSPLSSPSMSDAHFQSPTDDSTYFTPVLGSMHRHTASEDVPLVHAASLERTASLLARSIAMAKLTGTAPPPVPSHYHAAPFPINAPLPSLDTLRERARARLVNDDGSLPNSTSSNASSPTMPPSLRRNHTVTGVGGSKQNLSIGLGMSVDSSVPLDLRGSTRPAVLRSALASTRSGSGRSTAAPSSSRAATTASLEDDVALDSNRAAARINLMRKLSSRKLASPSQTDRVAAAQVDEAAVEQFASKLPQATVVGLRARSASAASERGRANGSNRSPLLVQVPAATHLYLSRRPDPIPVQVEDAPLRWPEDRSRETWAEGGGDRGNIRDFYEPDLHSLQGQTLTRGFGDVSEDAAAFRSQYQTVYEIDQAGPHVRHPDVYQVEDATPRMPDEYDIVTPRPPYEAPPQSKGNRLSSSNVNAIRENEQDQGEQRGPSPTASLIARKDSEARKFSDDSAISSEVSHDGNGIEYSQNQQAQAYQRKNFPIAVSSPRNTQTPRRSSIPQHLVPGPSRHAPHQSSLHATAAAAAPTGAPGFSLIQPFNTANDDSEDEVRRRGSSASSSVAFLTRGVRELPERTSNAGSILPMRNDSFVIPHESPAKLTDYLPSLSPLSGTQGPGLTRSSSLQGSGLSSSDEKNVVNAEASPSGVPHSIAFIMKGPGTTTDEAEHLEEEGDSPDWVLKEKRLTARIESKRQAGMTRSKNGAFPPPEENYQFPSPTASSPGTASESRASLPWQRPDREDSTDSTKALFEKLAVSPRERQRPSPFSVSYHPLPLSVGSPIIDADAGAVSPMGSHFSPQSIQPPAPTSTTPPLERMDSSYASKAQWFQSAMYKSAGVPALISAPPSAEMRRQTSGRSSNSRKVRLELLQEDTPSPLVVTTSASPDDLARPGTSHSDSSDYSSAIMSREGSGSSTHDALSLYTVEARHAPMHEEDLPANRIIAKLDSLLGTEHLMSDQQPTPLDQPPRKLLLHTPVLQVVNAHTVKDRHLFLFTDLLLITKPLIIDDPKTGMPTPSTLASQFIVKSIVELKQLKLQAEDEGHDDTAPPKKRHPFLVQFVDRFANDPKRAIATLIQKGGLSSDAATIANLIYRNPDLNRSQVGAYFTQPENRHILRVYIERFRFSGVRIDDTLRMFLMAVRLPHSRQSVEYVLGVLAMTWTEVNGATGFDPNLTFNLVVAIMKLNDALHSANSTEGHLFSRPNPSLSVDDFIASFRYSDPRSLVPEDLLTRIYASIRKERIEHASDNTIFSMTPDVEATLTPSKLPVSLTYRDPSDPITITIPEPDPKFNIKLHGTDLKFDPPILSFAKSRTQTFRVTGMALGVRAMVLIKTGANAPRYQGLPMNKAFSIERAFMQHKFQVSFTNHLNVKRKYMFSTLNAGLQRAWLRHLRERIAAAMAAPPAPTPALSAAEAVAVQALQDILIAPDELLPLLTAGSAASPRAHTAAPRNRGASRSRQGTPTAATRAALTNAGVLVRSNSVSKIYAAHYKIEADLHPDNARKKPSSPAVAALGSPVIGSPTVQSKEAEALEHLRASPYTKTGEELVLMTEQNSLLPVVLSFLGAGVGTAPLPMSANGSAFQLSPLPSRSGASYPSASFISNAPSSMAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NC19</accession>
    <name>A0A2X0NC19_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C043g12065 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C043g12065</name>
        <name evidence="2" type="ORF">BQ5605_C043G12065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000117">
        <property type="protein sequence ID" value="SGZ32075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NC19"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ32075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="447" mass="50086" checksum="DE16B4B7013BAE55" modified="2018-09-12" version="1">MTRVLRGRTRSRELYKVFAGWIESISFVRTESDHTVFVKSEGARKLFLSIHVDSGLLTGDGDLDGFIQQLKSRFEAKSSDEATFFLSQRILRDGKTGAAIVHQPHFISSILEDHNMAGCNSRLTSISLYKSHPRKDVTFDALTKPYRMIIGKLFFLNGTTRPDIAFAVSKFASHCNNFLQQDWEALLHILRYLKGTRDVGLLFPKAEGAPLLKGFVDANHGADPETCRSVTGFVFLCAGGAVLWMSKRQALVTISSTEAKYVVMSFAAREGIWLCRLLAKLGFAQSEPTKLHGDNQSAIQLAKHPAFHARTKHIGIHFHFIRDHIAEGTIKMVWIPMNTMAADVLTKGLGLRKHWDFVHAMGLVDASREGASWKERRVVEEVCAAPDPARDKLGLFLMFGSASDQVCTFPLFNSGFFSNVEGLRLFDEQIAEYGKVLLCRTHCNWQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NEA8</accession>
    <name>A0A2X0NEA8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C024g09799 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C024g09799</name>
        <name evidence="9" type="ORF">BQ5605_C024G09799</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ25920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NEA8"/>
    <dbReference type="STRING" id="796604.A0A2X0NEA8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.210">
        <property type="entry name" value="Ribonuclease P/MRP, subunit p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00754">
        <property type="entry name" value="RNase_P_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016848">
        <property type="entry name" value="RNase_P/MRP_Rpp29-subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036980">
        <property type="entry name" value="RNase_P/MRP_Rpp29_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023538">
        <property type="entry name" value="RNP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023534">
        <property type="entry name" value="Rof/RNase_P-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002730">
        <property type="entry name" value="Rpp29/RNP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01868">
        <property type="entry name" value="RNase_P-MRP_p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00538">
        <property type="entry name" value="POP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101744">
        <property type="entry name" value="Rof/RNase P subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGZ25920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="329" mass="35962" checksum="52F2C64362844C9B" modified="2018-09-12" version="1">MSTQASAVGGATSSNVKAGSTRAVQPSSSSQPSQSQKASAWQPYSILPPATRRKIDPRSTVLSKPYLESLNIPDDVAQERIANKYLQLEPPEGKESDRRKAELATRKAEKDKRTLAKIRQSGCGLVGKVRRKRLGRTVDEKIRYDSVLPLHHLWLGYMSELLGIRLEAPPIDSSTTEDTIGTTTTTATQKLDKTTLYPMFPPRQHDGPPMSELNVNVVALHSKLVKAEFVGSIVAVKRAKNPSLVGIQGIVLQETQGTFKLVTAKSQIKLVPKQGSVFDITLPLAAKDESNPSSRKLSFDLFGDQFAYRSAERVGKKWKAGTSAGEVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NH34</accession>
    <name>A0A2X0NH34_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C048g12346 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">BQ5605_C055g12635 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C048g12346</name>
        <name evidence="2" type="synonym">BQ5605_C055g12635</name>
        <name evidence="3" type="ORF">BQ5605_C048G12346</name>
        <name evidence="2" type="ORF">BQ5605_C055G12635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000092">
        <property type="protein sequence ID" value="SGZ29155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000110">
        <property type="protein sequence ID" value="SGZ30391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="540"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ29155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ30391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1333" mass="149513" checksum="7A7DDB1A611C3683" modified="2018-09-12" version="1">MIESLTVLTFNVRSIKNAVNQVKIIRYLKTLRPVPAAILLQEHHLSYNASREGFESAWPGACIRFTPHVLTLIPDGSPLAGHLLSSTPVVFAGAPRLDGRILRSVFRLEELDVEIINMYAPVQEDDRRDFFGLLHFNAPRPKTLRILAGDLNDCPDVSVDRVSITDRAWTPVSHWQTLLSKIAFNALDTVRHVHSCTPAFTRPHYRGRGEERKICSWSRIDYILVQCSWANRLLSASTLFDAPCSDHRPVVATFALPTSNADAEPPLSLPSTSDFISRLNPTVFDDQDFVASIPGVVDEVYRRLEGTAPLGDVYDAALRAVAVAGHARYRSTRADMRRLRAESQSVMEALEARGEHMNEAERDAYAFAKSRLDQLAVKEAQWLRIRAHVPSVDSREGQSASIRTRLNRRSRQTSIVSLEDVDGTETVDMQQALGIASRHAQSLFTPDPARGDPTNARRSLLGPIRAAKCYDDDRSDPTFGRRLPRQARVALDEPFTLLEVEAALKKTDSGRSPGPSGIPYELFKALPTYFAPKLLDLFNSIWEGGKMTASLAEGLVRLLPKNKPGANLKSLGAYRPITLRETTYKVLSKVLVARLNGVLGELLPPAQHGFMPSRRSADAGSHLTLLLEKLKSLGTEVFPEGALLSLDQQSAYDRVDHAWIFDVFEAFGFGERFISLLRALYDPETLGVRYLINGFPTELVRLLCGLGQGDPLSCPVWNITFQPFLDALVRRGIALDLQKVWPGGPRAQLTHLAFADDAVVVVESPAALSKLETLSQTWYEATNGKTNTDKTLVLPLGPNWLRDETAQALPTVQEGESFKWCGYAFFRHGDSKLFWTHVLDRIKAKTRAAGDRTLSPSGKVFYANAHIISTGLHVLSFDIPPQWFIKAAETALTDFVWGGAGRNTVARDFVFQAREDGGLGLISIGDIVHSVALRFWDAVAGSNEAIWAPLARESWRSLVAATRDFSPWGFFSSTARVEKLYRDSTRWGAVVAAARVTVPTIKSELLTLPELLSLPPRLPSLYAEGAKHAYDDADTVAKFAQIAELYWRDEGKGWALVGHRRGFWQHSKEPALQHEHVWSRVGQLLKAKALLPKTALRPARIPLKEAPRPRCFNFFGLTRPFTIRKLRRLVNVVRFPGREDRVKRFRDGTSQSDRKRFWRWLHDRFASAVEQDTHWRLMYDVTPTRKRQHTQGHASSPTCLFCGNDAAVIETVSHYFFECAYSTSFWGGVLRILFDKLGIEDTDVDPSTFTPEQLTMGLPLLRGRGRTTSRWMWVRLACAIGFQRLHLLRWRVHQRFELDKVVAPPSLPSALRAFERDFLSRAGFVPGARDWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NL54</accession>
    <name>A0A2X0NL54_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C011g06384 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C011g06384</name>
        <name evidence="1" type="ORF">BQ5605_C011G06384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NL54"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY12084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="97" mass="11809" checksum="C0E70B812F67F3F6" modified="2018-09-12" version="1">MTRNRRRYDSTTRQDRRRQADLFARFRLHKLSLCQYLLWYFSPSTQHNGVHNRRPKLFNSNWTQLKHVLDLIIQLAHEDDSDARGRINNWIANQSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NPI5</accession>
    <name>A0A2X0NPI5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C012g06786 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C012g06786</name>
        <name evidence="1" type="ORF">BQ5605_C012G06786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NPI5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY16166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="126" mass="14722" checksum="EB22D5613F6AC660" modified="2018-09-12" version="1">MVVTAWIGKKARSFYWIVFCRLPTAQQPALETQPRRAIGRCRGDDPVKQKKIQHEHVWSRVGQLLKAKALLPKTALRPARIPLKEAPRPRCFNFFGLTRPFTIRKLRRLVNVVRFPGREDRVKLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NPW4</accession>
    <name>A0A2X0NPW4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BQ5605_C012g06906 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C012g06906</name>
        <name evidence="5" type="ORF">BQ5605_C012G06906</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NPW4"/>
    <dbReference type="STRING" id="796604.A0A2X0NPW4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY16551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="151" mass="16654" checksum="F10FDC14FDC4BFAB" modified="2018-09-12" version="1">MQLFVRDLHGSSLSFSSIETVAELKFAVEDRTSIPLDDQRLVFGGRQLDDTRALADYGLRPGMTVGLALRLRGGGPKKRCGAYISATDRCSQASLRIVGDCSFCSTSFCGRHRLPEDHKCANLQSCKQEAFEKNKSKLEAEQTTSSKIQSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NSW1</accession>
    <name>A0A2X0NSW1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C011g06409 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C011g06409</name>
        <name evidence="25" type="ORF">BQ5605_C011G06409</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="416"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="655"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="757"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="664"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGY12160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1301" mass="141936" checksum="1B17BE9225B1A588" modified="2018-09-12" version="1">MSNPAISTRHATCATREAGRNGSTTSKPNARTDLEHANFQAIALLRRSVSLNIKKQIKDGFDHTPTDVLKMIKKAVAAGTVTDIFIKLQALLDAGPPPSGVDAFEKYQANTIELFNTLSGYNLTFDQVISIRLIHFGKDLYKEYYTQALRQDLDKLPDPIEALQTLQTQAESTPAHKPVAMVASLTATDRSSSTPSAPCRHCGGPHWNRKCPVKDKKSKASSAPSASLAAAPDISTLVNGPVRGYLTAAMSTLAKPSLILDSGATHHIVNDRACFTNFRKCKPAPLEGITGEAVNSIEGVGSAVVRSFDGSIGQLHHALFVPSAPVSLFSASRANAAGYDINLSRGKATVSVDGSICHTGEITNGLYHMHASLVDVTTLIEQPVNMEVALNADLKCDTCQAGKITHHPFPTVASNRSAQPLDRVHMDLLAFDGAVSLGGAKYALVIVDDYTRYLWAIPMSHKSDTFAAFKSWLAKVERSSSRKLLAVRSDNGGEFLSNEFSSFLEEQGITRQLSIPDTPQQNGVAERANRSITEGVRSMLHQSGLSHALWAEALATYVYVKNRSPHSANSGVTPHTRWHGSKPSAGHLRVFGCRAWKAATTEARSKLDPRGIPLVFVGYDLESKGYRLFDPATRQVFKSRSVTFFEDEFPARREGITAAHAPVDDDDDDDDDDEVVVLPDQHANQAPPDQAELPAALRFDAPGPAWQPPVGSRPRNPPARYGALASLRSTPSAFAFSLGKEVTELVADLEAAGIDTSTANRPLSEPEDPFSLPSSDPTTWNEAMRHPHAAAWKAGAIEEFRSMKDDLKVFSVVGLSSVPKGATILPSRHVFRTKRDKAGKMVSLKNRIVAQGCAQGPNSFNNTFSPTAKYTSIRTLIAHSASKGHHIIQADVDKAYLHGVLEEEIYMRVPTGIEGYEGKCLRLHRSIYGLKQAGRVWNDTINATLASLGYRRLACDECIYRHEDAGGDHYIALYVDDLLFFGPDLGEIDRVLDQLDTLYGVKRLGPAEWVLGVQVVRHDDGGISLLQRQYLLDVLARFNMSDCNPCKSPMEANLQLSPEPDTDSADNAIYRSMIGSLMYAVVATRPDLAHSVGYLSRFVGKAGDTHLEAAKRVLRYIKGSLDLGIHYTRTSAPLLGYEGYSDSDWGSDIQTSRSTMGYLFKLAGGAISWSSRLQPRVACSSTEAEYLGLSHAAKEAVFLRSLLTELGLDTSSPLRLLGDNQGAIALTQNPVFHARTKHLRMLEHFVREHVRNGEISVTYIPTHDMVADIFTKPLPRVVFQRHCDAIGLRRISGQEQGGVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NVP5</accession>
    <name>A0A2X0NVP5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C012g06990 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C012g06990</name>
        <name evidence="6" type="ORF">BQ5605_C012G06990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the assembly of cytochrome c oxidase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NVP5"/>
    <dbReference type="STRING" id="796604.A0A2X0NVP5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033108">
        <property type="term" value="P:mitochondrial respiratory chain complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051040">
        <property type="entry name" value="COX23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46811">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46811:SF1">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY16790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="81" mass="9359" checksum="4F09D70A5DF2CB50" modified="2018-09-12" version="1">MTTPQPTGQAPGSYNDAFRSRSAESEFADPCEIARQQSMKCLDRNNYNKAKCTDFFQAYRDCKQTWLTQRREDRRAGKDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NW45</accession>
    <name>A0A2X0NW45_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C012g06721 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C012g06721</name>
        <name evidence="4" type="ORF">BQ5605_C012G06721</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY15976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NW45"/>
    <dbReference type="STRING" id="796604.A0A2X0NW45"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22427">
        <property type="entry name" value="GH15728P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22427:SF7">
        <property type="entry name" value="GH15728P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015914141" evidence="2">
        <location>
            <begin position="21"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="247"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="648"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="679"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="752"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="811"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="854"/>
            <end position="863"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY15976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1059" mass="115010" checksum="60AE786A2F02EE7A" modified="2018-09-12" version="1">MSGSVWRWCLALDCLSLPYARVPPAPLTFTPTATLGPPRTTLLTPVTVASTEQSSCQKWLADLSKLRHEARRFFGDVCWAAHGPTRPGRSCPDEVLVYAHKAIVYSRSSGSFQERFIQCSPALHCSDSVASSFNTGTSARDDARDAHFLRSTSSASLESIVTATTSSATLIAESSDHVVRLMLADTDPALFEAWLDVLYLGTQGTEGVHVLFEGFHESIREDSVPGLTGIAKLREDLLYCWRSKLYADVTIVLDDGGYAASSFASHRAILAARVPYFACILLGEFSDAQTCILTLPSPLFSSASFTFILGYVYSGTLHFSSRKFDLATALEIWRGAAFLGLDLLQEQVEVSIESMMTPNRAARIYRFALAPDVQSARLARGALMVITGHFGQVWDSAYIGTLDHSSQKALFDQVCSGISAETSTSVVKQALQLRKRIETNRHAWVHHIRAMLDAVEEHLVEVLSRDLAAVVTSESFVDLIDGVGFSADVLEHLLELVVRGLAESRACATYQALVGSVLLREEGILIDAKVLVEDARNGIAKYIKTRWMSIRDTGEFTRLQAWCLKELADHISVAEADLLYQPTASKRPPIRTSVITPTIARPPSKLVLNENAQWQLASGENQLRALDSRSARSTDLAAHIGLPIVDVPRRATHIDPPGSAARGDERPSDRTSAARHARSLGSASSSSRIVRSASASNAAHHRVPVGRRGPAGSTSTEIGPGTAETRVSTSFDGATTVRAGRREAGVLPTLASEVSTAAKTRSRTGSVDSRASPTSSGRIHRPSKNPPAIQRLSAPSTIVPLRCESVGGPATSRETSDSTSTSKPPTGISPLYPPKLARRTTSAISLTAVRAPSSRPTALNSKKSSPDSEAHLHLSKATPQHSANLYIQDRITNEDSLAICASRDARTKLPFQRHQNPRGTTLLAGIPCIATINQSDVRRIQIKAVVRYIGPVEWATPDTHWVGVEVAEGDIPAEVEANDEWNDGSRDGFRYFDLRRCPEPTARRDAEIREQAEYQLAFATREAPTRSRPRSSLGVNSRGESMEVSRGLFVRPSSIVYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NWD9</accession>
    <name>A0A2X0NWD9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C012g06831 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C012g06831</name>
        <name evidence="1" type="ORF">BQ5605_C012G06831</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NWD9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY16286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="166" mass="19097" checksum="23A0068EC240548E" modified="2018-09-12" version="1">MCIVGMHLMRQDFIQRFNDLHPDLSPPLREADDLNQRLVPYHGGLLTFQPDRAIFFKDQGRLSTMPGHLTTEEISYLRKRGICFGLQGYSGSGFDNVVDARFPLPPPLPSDLLGMPELIEESIVRSRRPEQEEDLVTMGGKEGIRIATTSGMPWWRWYVHAKRRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NXE5</accession>
    <name>A0A2X0NXE5_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Very long-chain fatty acid transport protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Very-long-chain acyl-CoA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">BQ5605_C014g07560</name>
        <name evidence="22" type="ORF">BQ5605_C014G07560</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Acyl-CoA synthetase required for both the import of long chain fatty acids (LCFAs) (C14-C18) and the activation very long chain fatty acids (VLCFAs) (C20-C26) by esterification of the fatty acids into metabolically active CoA-thioesters for subsequent degradation or incorporation into phospholipids. The transport and fatty acyl-CoA synthetase activities are genetically separable and are thus independent activities. Esterifies VLCFAs in the peroxisome matrix. The VLCFAs are actively transported into peroxisomes by a PXA1-PXA2 heterodimeric transporter in the peroxisomal membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54536"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:138261"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY19093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NXE5"/>
    <dbReference type="STRING" id="796604.A0A2X0NXE5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000020">
        <property type="entry name" value="Long-chain fatty acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000019">
        <property type="entry name" value="Long-chain fatty acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF15">
        <property type="entry name" value="FATTY ACID TRANSPORT PROTEIN 3, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="13" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="14 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="21">
        <location>
            <begin position="83"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00078285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="SGY19093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="658" mass="72734" checksum="576E67EC2D1DD8AB" modified="2018-09-12" version="1">MPFKNCPQGRLIIIVGRFAQRVGLDLVLPTLPVIAGGIAAAAYLDAKHFIAADLVKARALIDVTVSLKRNNARDRNSIYYIFNDNVAKLKDQECYVCENVRLTWGQADKKANQFAHWLLSRGLKRGDTVALYMPNKPAYVIIFLACLAIDVVPAFINYNLEDDGLRHCVSVAKAQMIIYESTLSASIAGVAEALRQTNPRLQFVNWVDNFSSGGEKAGAVIKDSVTLNLPKALDHMSRDRIPDKQRAGLTWQSPACLIYTSGTTGLPKAAIVTHGRSATAFKMWTRINHFGTKTRIYTPMPLYHSTAMLLAIGAAWNAGATVIIGRKFSASTFWKDVRESNTNVIQYVGEVLRYLLAVPPSALDKEHNVKLAYGNGCRPDVWNKFRDRFGVDVISEFFASSEGNGSLYNYNGNNFGAGAVGHEGTLAGWARRVKQAIVKVDSLTEEPYRNEKGFCVRTEDDEPGELLCQIDPDSPFMSFAGYYGNDGATEKKIMRDVFSKGDAYFRTGDLLSRSKEGFYYFADRLGDTFRWKSENVSTTAVSEAMGAIVDEANVYGVLVPSHEGRAGCAAIPATSQVDFEKLSVHVQKVLPKYAQPLFIRIVQKMESTGTEKQLKVALRNEGVDPAKVSDPVYWLSGGKYKPFTKTEWESLQGGKVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-11-27" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NZH1</accession>
    <name>A0A2X0NZH1_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-B22</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase B22 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">BQ5605_C016g08151</name>
        <name evidence="18" type="ORF">BQ5605_C016G08151</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Mammalian complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY20828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NZH1"/>
    <dbReference type="STRING" id="796604.A0A2X0NZH1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20263">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045292">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033034">
        <property type="entry name" value="NDUFB9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B22 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="17">
        <location>
            <begin position="21"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="SGY20828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="121" mass="14220" checksum="A88041C1595EC467" modified="2018-09-12" version="1">MAPSATAQAVAPFSQAHRRYVAHLYRRALKGALDWYVRRDLWRERAIEIRVQFERNRNVRDPRAVAALLHEAEKAVQDMSHPDPYRAPMFPDGTKWERNLPPPMFTQEQKAEALKAFRDEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P0B4</accession>
    <name>A0A2X0P0B4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C001g00531 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C001g00531</name>
        <name evidence="9" type="ORF">BQ5605_C001G00531</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY47432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P0B4"/>
    <dbReference type="STRING" id="796604.A0A2X0P0B4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="308"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY47432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="916" mass="100474" checksum="6294DD2DAC38C37C" modified="2018-09-12" version="1">MADQSVQGQSQSAELTSAQPARTHVCQAPGCTHSYARIEHLGEPLCRNPFFRFEWECARVLTRSRPRAERHARIHEPGHKYSCTTCGRGFARIDVLKRHEKLHQRDAESGLLQTNSTVRKQAALERTARACLACAASKVKCSGVPNCERCTNSGRDCVAAVEQSTDRQPSRKRARPGSLSASDVVEPSDYLVDPSIANTETEASLSLIEMALQPSDGFSLDTAPTRNFEDVSGHFPSVQTDHNSDFTHTLNSLFQPMLSLGPLSADDLADPFDTIFGVSTGPLQLNQDNTNFSFEWLGNQQQTPLWNSFTSPQGGNPPFDSGADGDVPSSQGNRVGGRVTLAPGGLATRHASPAADNERPPDRPWPMVWNPTEHDSQIEVDGTMPGAFERDELADHDPPSFLPMDNDVRMCILEALQFAKLQGHGYHAVFRTLANMSLKVYNHFISLYFTHVHRRLPMLHLPSFNPRKTFGLLLLSMTAIGALYAQMPRAHALGRILISVAKLAIGELTVDDNRHARSLPTLQANLLCSVAKWLGSARSLELTEVYRGTHTTALRRLGIFEDIVPEIAPDASIQSQWAHFIKYEERKRTAAVCFLLESEMTTLLHLPPHVPFVELQVALPCDEELWNAPTAERWNELRQSRSNSMQTQAIAKLITADTNYSLPPSIAISPLGHEVLVNGLHIMMYSARQLQQVGLEHLSEQAGAHVRKALSRLSKGYDEFSPVFGDNNNSDDDFTPAYVSYHMAHLASYLAVADLDAVAGRGSSAKSRTTTQNLIAWMKSNPDKARAVAVHSGQVVRRIRDKPLFGKSFTPLAPSSVFYAALCLHLYALSVDPLLSISPGPISTFPLDQAQQGEQVITWVAIGGYFASLQGVDCLAGSAAASQVLIMLAGLSNWSGRAWRIGHVLKDVLQAVASSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P0T8</accession>
    <name>A0A2X0P0T8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytochrome b</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BQ5605_C082g12985</name>
        <name evidence="16" type="ORF">BQ5605_C082G12985</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000033">
        <property type="protein sequence ID" value="SGY28112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P0T8"/>
    <dbReference type="STRING" id="796604.A0A2X0P0T8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.810.10">
        <property type="entry name" value="Cytochrome Bc1 Complex, Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005798">
        <property type="entry name" value="Cyt_b/b6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036150">
        <property type="entry name" value="Cyt_b/b6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027387">
        <property type="entry name" value="Cytb/b6-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81648">
        <property type="entry name" value="a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51003">
        <property type="entry name" value="CYTB_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b/b6 C-terminal region profile" evidence="15">
        <location>
            <begin position="16"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SGY28112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="94" mass="10697" checksum="BDB4E9F940D38A68" modified="2018-09-12" version="1">MHLLALHEHGSSNPLGVSGNTDRLPFHPYFTFKDLVTVFLFLLVLSVMVFYAPNYLGHSDNYIPANPMQTPPSIKYTIDLPALFYFSFCKNKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P281</accession>
    <name>A0A2X0P281_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01688 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01688</name>
        <name evidence="2" type="ORF">BQ5605_C002G01688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY34822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P281"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY34822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="103" mass="11404" checksum="F855F956D34B09AD" modified="2018-09-12" version="1">MTGMTGEFSRTYGSFSTARRKRSSYEPCYRQPLKCSSGMYGPKRVASINHKSGRSLALSQGGDRSVTQTASDQTIHRQLDLKPAQEPRVLPRIQGERIPSGNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P3I8</accession>
    <name>A0A2X0P3I8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C003g02121 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C003g02121</name>
        <name evidence="7" type="ORF">BQ5605_C003G02121</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY39001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P3I8"/>
    <dbReference type="STRING" id="796604.A0A2X0P3I8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF42">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015914816" evidence="5">
        <location>
            <begin position="27"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="6">
        <location>
            <begin position="191"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="81"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY39001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="654" mass="73065" checksum="76D5D612661EA291" modified="2018-09-12" version="1">MIGSSNIAAAALCVAAGLCIVPTTDAALQLERDPAARRSASPSEALGSSSASPYQRQLGLDRSELVKAGYVEDAASAYTPLHRRKRSGRRAAVPSANGRARSDALKGSLSRRRRVASRATPTESDAEETSPTLLRPFDYANDKIRGVSLGGWLVTEPFIKASLYLEPNRADWRIQDEWTFCQYQDREVAATALRDHWDSWMTELDIEEIAEAGLNHIRVPVGYWAVDIDIAAGEPYIPGSLYYLDAAIKWAKKAGLRVLIDLYVCSVYVRARFQTTHLFSPHSSRHGVPGSQNALDNSGRRGSIEWNKNATNLVRTRNVLKVLADEFSKPEYHNVVTAIQPINEPWGHEPGVLAAAEDYYYDGFQLAKLDGTDPSRSLLYVIHDAFKGVTHWKDFMRNSTYEGKVMIDTHIYSIFDEQEIRFSEAQRIEHYCEYGHYLSQITAGGLRPVVGEWSTAPTDCNQAFPGANYSRSEQQIGWPSRYDGSWPGTRAMGRCRDISGNGEKFAIDYREQLGRLWEVQVSTYEQGSGWIMWTWKTETTADFSYQAGLDHGWIPKDVMQRTWQDLCKVSPPQRLRLGTIEDGGEADELPTDFLAVGEKVPSSIELKEDDTTDAPVAVYIANTHGRLDALYDTASTVLLLFADAIDIVFLYIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P4A0</accession>
    <name>A0A2X0P4A0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C003g02450 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C003g02450</name>
        <name evidence="7" type="ORF">BQ5605_C003G02450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NGG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY40952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P4A0"/>
    <dbReference type="STRING" id="796604.A0A2X0P4A0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019340">
        <property type="entry name" value="Histone_AcTrfase_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10198">
        <property type="entry name" value="Ada3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="142"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="241"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="525"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="583"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="719"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="10"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="596"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="726"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY40952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="811" mass="90016" checksum="EB927A7875BC9289" modified="2018-09-12" version="1">MVPAPVAGKTPAPISTSTATTSSASKTTSTPMTPSTSTPTTSNTSSLSNSLSSNASPSHLRKFSLHPPSLLTPSSILMTIANGSSSLNATQLANLRTVLTSARLQANERLVIRDSNKKNLVDRQLHEKKLAEESARLKDLERKKKREEEERKEKEKAQKLEKERLQREHEAQERRRKEEEEFRQIKKKEEELKIKEDEEKRLEAIRLAREAKERMEKEKEKKRLEEVAEAAAQAIAAAATAAAEAKAAAEAKEAKENAHEEAGKEDVEMEQADAVDSKVLDSTASVSAQGEWVELVPTINIAGSMEPEDDEEGGDQPRPPVRDSKKKKRKRDQVVDSDDEDGRGSSHDSDSDTQPLAQKIRKLDAPSSESGKLGFKKESPTPSPVIPVTPLRDGPSTSESIVNPYEGLTPIERKLKEDKFVKHSIPIRPPAPGTATAFYLPTQSLVPPKPISITPTPTPKRQADVSGDFSTAKPGTQIAHHTFHTWADAYLRPFGEDDLAFLAPKPDDWAPYFIPLLGKHYTEQWEEEDHDLPPSNTSHYASPLEPPPLPRIKLDALNEDALGSEVVTLGPLSERLVAALAFTGGGRSENEDDEPSGTNGMTHPNGTGLDLPAQLVDPGALIRPLDAVELEERIKRELRFIGLLPEDEVDWSSREDDEISSALRSCQRHLHRQTMVNEARKVVLSGIVKDRMAYQDYETTRDAQERVIENGWLKRQKTQVKKKGKAARDRNRNKKDKEVEEDAEGVEATGKQPLSLSLLQAVDRRHVLVESFRPFFEEERAGRFWGIPTTSVYEGLVEETEEGVLKGELAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P4C0</accession>
    <name>A0A2X0P4C0_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">H/ACA ribonucleoprotein complex subunit CBF5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">H/ACA ribonucleoprotein complex subunit cbf5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C003g02470</name>
        <name evidence="11" type="ORF">BQ5605_C003G02470</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>uridine in 5S rRNA = pseudouridine in 5S rRNA</text>
            <dbReference type="Rhea" id="RHEA:47036"/>
            <dbReference type="Rhea" id="RHEA-COMP:11730"/>
            <dbReference type="Rhea" id="RHEA-COMP:11731"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine in snRNA = pseudouridine in snRNA</text>
            <dbReference type="Rhea" id="RHEA:51124"/>
            <dbReference type="Rhea" id="RHEA-COMP:12891"/>
            <dbReference type="Rhea" id="RHEA-COMP:12892"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY41102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P4C0"/>
    <dbReference type="STRING" id="796604.A0A2X0P4C0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000495">
        <property type="term" value="P:box H/ACA sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02572">
        <property type="entry name" value="PseudoU_synth_hDyskerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21148">
        <property type="entry name" value="PUA_Cbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012960">
        <property type="entry name" value="Dyskerin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004802">
        <property type="entry name" value="tRNA_PsdUridine_synth_B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00425">
        <property type="entry name" value="CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003280">
        <property type="entry name" value="PRK04270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127">
        <property type="entry name" value="CENTROMERE/MICROTUBULE BINDING PROTEIN CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT DKC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08068">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01136">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dyskerin-like" evidence="10">
        <location>
            <begin position="26"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="9">
        <location>
            <begin position="275"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="403"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="409"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="448"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="478"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="514"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00072225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY41102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="525" mass="57717" checksum="96CD11978B32DE3C" modified="2018-09-12" version="1">MSSSIANTQLTSDFAIKPESVTPTLNTKDWPLLLKNYDKLLVRSAHFTPIPAGSSPLKRDLVSYIKTGVINLDKPSNPSSHEVVAWIRRILRVEKTGHSGTLDPKVTGCLTVCIDRATRLVKSQQGAGKEYVCVVRLHAGIDGEKALARALETLTGALFQRPPLISAVKRQLRVRTIYQAKLIEFDNDRHLGVFWVSCEAGTYIRTLCVHLGLLLGCGGHMQELRRVRSGAMGEGDDIVTMHDVLDAQWLYDNTRDESYLRRVVRPLESLLVGYKRIVVKDSAVNAVCYGAKLMIPGLLRYESDIELNEEVVLMTTKGEAIAIGIAQMTTVELSTCDHGVVAKVKRCIMDRDTYPRKWGLGPKAQEKKKMVKDGKLDKHGRVNEKTPAGWKSEYVDYSKQGEGLGASSAAAPTTIPTQPVATEIVPPPTASTSATAVESVVEDAKAEKKAKKDKKRKAEAEPESEAAVAVEETEEERKKRKEEKKAAKKAKLAASGAGDESMVMTEGEGEEKEKKKKKKDKKAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P4H4</accession>
    <name>A0A2X0P4H4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C003g02530 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C003g02530</name>
        <name evidence="1" type="ORF">BQ5605_C003G02530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY41593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P4H4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY41593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="84" mass="9277" checksum="DB156068E43FE4C7" modified="2018-09-12" version="1">MPCYSKGALFRAKISEGNWAKRADNSQAPPKGRGVELTLERAQLLIDIDRDRRARAVDLHFCTFVEHKATSSNSTEEGTVTISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P6V0</accession>
    <name>A0A2X0P6V0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C005g03563 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C005g03563</name>
        <name evidence="2" type="ORF">BQ5605_C005G03563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0P6V0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY77136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="81" mass="9044" checksum="D35206F3194F4AEA" modified="2018-09-12" version="1">MLCEKECRPPIHRDMLTVGLQVAAFRQHPFRYPKAGKDEGKQDEKGQQGHGKGQREQAGTRKGQGQGARRGSEGRGSWRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0P7N1</accession>
    <name>A0A2X0P7N1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C006g03881 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C006g03881</name>
        <name evidence="3" type="ORF">BQ5605_C006G03881</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY54470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1048"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1321"/>
            <end position="1345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY54470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1345" mass="148721" checksum="707DD400E041AAB0" modified="2018-09-12" version="1">MRVPQGIDMPGKILRLSKSIYGLRQAGTIWNAEIDSTLRSLGYVPTRSDICIYCRKHDGHSHYIALYVDDLLLVGPSTAEIDRVLDALELAYGIKCLGPAEYILGIQVKRGHNGSITLSQERYLRDILARFQFADAKPASVPMQPGVVLDFENSSATPEDRTRYLQAIGSLMCAAVGTCPDLAFVVSYLAHFLQQSGPEHWTAIKQVLRYTKGTLDLGLTYRKTNQPLHGYLDANWGACLTTSRSTMGYAFILSGAAIAWCSKREHRVTKSTTDAEYLSLSYASGDAIHLSELGAPVPGPVVLYGDNQRSLALAQHPTNHQGSRHVHISEHYVRKRVAEKEIEVRYITTGNMFADIFTKALGPKPFIFHWTNLGLRGAVVLILLGTKDGKIYLCYAQGLIVGELAGANILKGMAKVAVIKHRQNAQGKDMRGYVRDEALLDFEHALALASPTALRVVQKTIGGISMCTLQFGLDEPHMQRVVQKILSDGKTSNVHVDDTELRQVIRTTRSYLKDKEAEDRLRGQKIFCHELIGMVGPPIMYETTRELEGIFRGPNPPIAGTKVRVYMLAPNDVSCPAQYLAAFVIGDLTSSSEAADEFESVIQFLVDAGLGHLLASISADGAASEGLLQRVMAERLGGDEGYTGEGNHRRELAHVIPSPGPNKVFPAIRLASVQVGNTPTCFDRDEKHLSKNLRSACDSGARAIYGGTGCIGYRALLTLLDVEESERTFYLRDVIGRDRQDDKATHRAFSEATLSLACRLHEDGKVDADAIVFLFLCGELHDAIQNRSLQPIERIKMLLTVRYTFAGWLTFVRNRPGYNAQSFVAKETLDGMRKVVDTNIALIRNYRDFWPEEAFIPWRHGTEMVEHFFGGLRKVVQEFDALEFLQSASKVTALLGLMRKLKTETAGSRQGYHHTYDRLDDLDLVAMRTYPNDEEIRSTSLVAAGLAEELLLGLRMWDTIHYQKSDQVEEEIPVNGSEPWHFEPEDTEPVSYLADLDRTLNGIRTKTCQGLVVLDPKERKSVENAAYDEADAQAEERFLLDAIETANESLPGRGRHGAPTSTAQDFDPTSKAQLSEHGEVHSSVLRGLVQSMGAARLEAVSGVARSIRWTGQGTFSRFSTANETDNIGYIEEGRKEVRMQLRARQYTVFAKIPTFGSIDGNVTSAMPLKIGSLVCFGLKRGIIPVSCDASNIGEEQLSIGLVRYMYAKATSNHCDRAETDSLALLSNVVLQELRVVSKGRYSTHMIDGTTRFFGLDARQIIQSLESSSTPALTLAPQDSVAYLGERVFDLSQQAEARFCFLRRYNGLRNASVSLSNQMKGVKDVGSKRKAASADEEPSAKQNRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PAQ3</accession>
    <name>A0A2X0PAQ3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C004g02726 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C004g02726</name>
        <name evidence="7" type="ORF">BQ5605_C004G02726</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY66935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PAQ3"/>
    <dbReference type="STRING" id="796604.A0A2X0PAQ3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="6">
        <location>
            <begin position="24"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY66935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="140" mass="15636" checksum="D3C9A6FAE31AB7C3" modified="2018-09-12" version="1">MSSQPLLQRAPNKRIALPVRVEPKVFFANERTFLSWLNFTVVLGGLAVGLLNFGDRVGKIAAGMFTVVAMSIMIYALITYHWRANAIRKRGSGPYDDRLGPTVLCLALLSAIIINFILRVRSTLSHRTDLASELFWPGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PB15</accession>
    <name>A0A2X0PB15_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C034g11282 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C034g11282</name>
        <name evidence="4" type="ORF">BQ5605_C034G11282</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000065">
        <property type="protein sequence ID" value="SGY99362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PB15"/>
    <dbReference type="STRING" id="796604.A0A2X0PB15"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14011">
        <property type="entry name" value="PK_SCY1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF6">
        <property type="entry name" value="SCY1-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015986954" evidence="2">
        <location>
            <begin position="23"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="107"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="720"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="774"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="720"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="800"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="831"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="857"/>
            <end position="950"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGY99362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="994" mass="106393" checksum="6D4DB31B054C41EB" modified="2018-09-12" version="1">MLLMISWLSPSLFLSVGVHVAACPATTVFEQRRSDQAAFATMEYASAFLSAASSLGARSALSSNYTLATATSPSSSSSSSSATAAGAISSSSSSAPIRTLQIGPWKVERASHNSSGKQVSIWSCDKSSLVAPTGALKRDPNAARTLEKAVETLKKEVRTGSWCAASLSRLRHPCILEMAEPIEETRSVITFATEPVTASLRQAIAASASTSSAAGSISRGSDRRNGSSSSYAAVQQQSDLELDEVEIQKGLSQLAKGLQFLHESAKTIHGNLTPEAVVINAKGDWKLSGFGLSIPLFGPDGVATKWEFPAYDHGLPATIQRNYDYIAPEYILDEANPTPANDMYSLGCILHSIHTHAGPPFQNRQSLSNARTNIEEGLSRGMVRPQWRRLTEEAQSALGQLVTRYPNQRISAAAFLAHGYFSSLLVSTLNFIARDAFASQSTEAQTGFLKGLLIVLPQFSDKVNRRKVLPSLLEETNKTHLIPFLLPNIAYIGQRMDVDAFRSQVLPHLIPLFKIKDPPQAILALLDSLPLFSEKSTPTSFREEVMPLVYYSLESDNPVVLEKALKAVPSLCETLDYTTVKQTLFPKITTVSPPLSQLPVYIRQLTDALALQVFTKTTMLSVKVNTLICFHSMTSTLDKFTITERLVPLLAKIKTKEPAVMLATLEVCSKIGDKVDLEALASQILPQLWRWSMGPLLSADQFAKFMSVIKRIGHRVETEHTKALQEQKRLEESTSDGSLSRGGGGAGSTPMDFEALVRGGAGLGRATEVAADIFGDDSPGSVTTSHGFTPPPNGVASFAPSRPSPRSSLSHSSLGAKPVPASTLNSSAFGAPTASMTPTTSSLSSMTLISPPPPPAASSAFASSSSNSMSSFTSLEPTRSSLSSLPSLPNQTNNSTTSSYSSPRPNYHSLTATTTTNTLPPLVPNSSSFSPPNPNPWASSTPSQPSMSMSYVAPAPPSTPAPKQWDVLQPKVVTQPRKPSNGDFGAWSDFDPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PBH1</accession>
    <name>A0A2X0PBH1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BQ5605_C004g03016 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C004g03016</name>
        <name evidence="8" type="ORF">BQ5605_C004G03016</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY69449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PBH1"/>
    <dbReference type="STRING" id="796604.A0A2X0PBH1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12676">
        <property type="entry name" value="RRM3_Nop4p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000406">
        <property type="entry name" value="Related to Nucleolar protein NOP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034808">
        <property type="entry name" value="Nop4p_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="123"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="481"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="681"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="251"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="331"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="561"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="603"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1039"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1105"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="363"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="608"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1142"/>
            <end position="1151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY69449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1189" mass="129488" checksum="2164752BDDB200C7" modified="2018-09-12" version="1">MGPQRYFDQGGDDISRPHHDGGSHRGGDRGRGGGGGRGARGSRGSRGRGGASSGSSRGGARGDGAHHEARPKTEPFQPKQGFIAAGLKAYADAAETTPDNDEQNSEQKAKISEGWKDKTTTQTTLYLTNLPATLTSPELSLIFSSYAPLRSAFVVSAATKNASGPGGAGPSSANAISTGAGRDRTGKATSRGFGYVRFVLRTDADKCLEEWGSKSGMPRSACSELESAEGLEKVDWDKLCGREGMKMSWAKKKLKEGEEPEGPKAKKEKKEKIAKPAATDDAEKSEEQEAELEQAPRWRPGVFDHAASRSVVVQGIPTEADLEKLRAAKAKKASEMDVDVEADAGADQDGDDNDEATTKVDDAEADDEDGDNAEESGKAVDWKKALKQKAKKSGDVEDVKWPVVLPSGDIAGESARGDEIIFRKANVDFLYAAIIVMYSPRHAHDVMKKLHNHVFRGLVVTAAVKSSWDLCQRQGRAKGGGRLVVRNLGFDITLADIRAAFARFGSLHSITLPEDPKTGKPRGFAFVYYVTKSCAEAALKAMNGTRIYAGMAADRIAEEGGKLGKKKEVREKKKAALKESRGGGGEKGRLVAVDWALSKDDWKKAQEAEVDEAEAGSDEDTEEHSDSDDDDSQEEEDDDSDLSPVEEDESDDEDEGEELELSDGDSDVDEEPQSTELEKGTTLFVRNMSFEATEPELYDLCKEFGPVRYARIVYDPTTKRSRGTAFVCFWKREDAQKMLEASESLNAGLFVGETSHKRNKGASQSLLMADPGTSEASKLTLHGRVLAAVAAVSKDDADKLREDRDKKGGAKSDRRNLYLMREGVIFPSWAIAQTLHPSDMAARQLSFDARKGLLRSNPSLYISRTRLSVRQVPLYVTDGMMKRLANFAIREFDKEVKAGLQKPLTADELDDSVVDASGSLPAPSKVERFKGVPPSRVRQAKILRQSDRVDPLTGLGRSKGYGFLEMGSHADALRVLRWANANKDIGALLRKWWRDALEAMIEKVQRGEGSVGKGAALKEKEERLKRLREKMSELVEEEELAAGKAARREAAGKTTGEGGRSTRCLIVEFSIENAVTVSIAISSPPDSETDILNVFAQTKRRAEKVARARERAKRSKDRDGSDDDGEDDSRDRGKSSPKKRRRQEDGDDSKPAKKGKKPAEEAEGEPEAKEGRTGLSIGAIIGKKRRQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PBW7</accession>
    <name>A0A2X0PBW7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C004g03055 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C004g03055</name>
        <name evidence="3" type="ORF">BQ5605_C004G03055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY69739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0PBW7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1279"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="630"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="691"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1824"/>
            <end position="1858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1843"/>
            <end position="1854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY69739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2043" mass="228038" checksum="D8BC5562A3896FB3" modified="2018-09-12" version="1">METGDTGPPPPSASAATSVPIGTKETQVPIAAATYATAAIQKTKQTPEQQTQQQHRAKALTQMFEVMGAVPGNRTDRWLQATFATDEYPVATATSLKYSALNANRSIRNIFDFALDVTLTVQGASKASPADKADLLGCVTRLLSPQSPLCFDAEVTLPEHLAAFAPQIRGIQHSSFVRAGVVNHRISVGFVSAKARDSALTWHSAKAHFAKAHHFYHNMVELRINVVVAAVPSRDAIVDSFKSIVTKITAKGHHCELVQVLRVIHVDNDSAYAHLAGKFSAFIRFDDNTLFKAPNNTLKELLPSKVSLATRGNMHTAVRHDYEREAACARCHFVGHVETCALEQERRQKEANNNTGRHNKYHNNPTNNNDTTNTNNTNNDTSEVVAPGRALGTDQLESRNQFAGLEVEGGQEDDIEEEVAGKEGEEKEQVEEGDEDTGAKADDEDSDSDGNAGAGIDKAGGDGKDDNKDDDEDDDKDEQDDSSEGSEQREDEGNDGDDVMKDGAEEEDEGMETEVEEEVEQEQGVQDDSIMIIDDGQTMITTVSRESTPRSPSWPLLEPPLSPETLAKSLREGAEWDRANAEAAARVQAEKEAIINAQLDAQEPLVRHQYAEWGQEDGQLRFINIRGTGSRSNKKMKRSQTVADLSDPSDDPVDVKRVLNRVKGRAGKEVAGQGKRVTRSMSAAAAMQVEGAKAKAEKGKGVEEEKRWSDHEPEDDILPEFPLFEDDTTAKSTWNVRRCMGIPEKRRNIYTYLSTFKASAILLQEHFIKPELWQCIKNEYEGKVFISKHCLTLIPADSPLIDAEILRTHSALHGRILFTSFRLRGDIRILEINNIYAPVDTKQRLTFFDKLHFHRTQSTHLRLLGGDLNDCPLPVINRRNQGRHGHHWPILIGKLNSPYTDCIQFKHPLTPSFTRPNIVRKRPKSFSRLDYFLLQRTHQKRLVQASTIYDHPKDLLDHRPVSIVLVLLDERGDAAQPNNSLPTTSNQLHRINAATFKTAAFQGMLEGWLEGASGEEPVGELKVVLGNCEKEGRELARREHRERVERMAVLVGRVQDVEALPVMGDEETAEWTRTTEELRRVVNERARQLRIRAHVPEIATEERLSRPVHAKLAARSSDSKITALRLPNGELTHDIDVALDHTQAHFQRLYNLEPRDRDHVEQLRDNFLAPIRAARTCDNPSSDPLFLRQLSEAHIELLQQPITEDKVVAAIATTHPGQSPGPSGVPYELYHTAPRAWAKALSRAFNAMTERGSLSPKQGQGLVRLLFKHHKIGADRAELSSYRPITLRECDYKLFTKVYVARLNHVLPDLLPPQQHGFVKGRRSADASFHLRLLIEELGARGTELPDAALLSLDQSSAYDLVEHEWIFAIFDALGAPATFQRVLRMLYSGDLTTAQYIINGFLTPPVRLTCGLGQGDPASSSVWDVVPFLDALHRRGIALNLSLPTIHPYPQSRTITSLAFANNIVVAVAGSESLTLLDDLALDWRLATNGRLNTDKTIVLPIGCRWEAGDRPLVVKAEGESLEWIGLSFDPTGNTELANVNLVARLEAVLDSARDWGLTHHTQVFYVNRYTIPKILHILSADIPPLEVVKELDRILVDFVRGGKRRSCYGKDVVFTPRFKGGLGVMRMQDVVNSVAAHVWNVLLGGLDAIWQGLAHAAIVQAHPAPDFDLATDAWPCNYTPIQTDLHPRWQAVLKVPSMHNAQVKPRTLTLANLLALPIKLHTLHYLPGAPAVSRSPYDADYAAFANYAKVADLFRRELYPGGGFHLWTPPTDVVVSNSEYDQRGRPQREHIVAWYRHAINRLRFTPIAQPVAAVRIDGPPRVRPRSEVRPTTPLESILPHPIDPPQRLPRPALPDQSTQYNLLSMDRPYTLRRVRRVLNAKAFTDTIGFRDSLQPDDLKGFWKGVNSKALTAREREVWFKLVRNFTPTRSLQFHQKHDDSPACLGRGVLCDALGLDTIDNTHYTAVQRMFGLPKLKASLRDQEGAGRTIEIFTGLVLEMISSGRWGMQKWGTRMEGVVRRRIILEERLKLRAGGAWGRRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PD71</accession>
    <name>A0A2X0PD71_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C005g03698 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C005g03698</name>
        <name evidence="1" type="ORF">BQ5605_C005G03698</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PD71"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY77693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="75" mass="8443" checksum="8144991B27558968" modified="2018-09-12" version="1">MSTHPAAMLISPSSRVLVVHPDAESSLRLIGQHLGAWLDKRQLLLPTWRTMIRCSLQQLILSNVKLSLEQLQITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PEX1</accession>
    <name>A0A2X0PEX1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BQ5605_C023g09624 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BQ5605_C023g09624</name>
        <name evidence="4" type="ORF">BQ5605_C023G09624</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase E subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ23702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PEX1"/>
    <dbReference type="STRING" id="796604.A0A2X0PEX1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033178">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, catalytic domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.30">
        <property type="entry name" value="ATP synthase, E subunit, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00311">
        <property type="entry name" value="ATP_synth_E_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038495">
        <property type="entry name" value="ATPase_E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002842">
        <property type="entry name" value="ATPase_V1_Esu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45715">
        <property type="entry name" value="ATPASE H+-TRANSPORTING V1 SUBUNIT E1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01991">
        <property type="entry name" value="vATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160527">
        <property type="entry name" value="V-type ATPase subunit E-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SGZ23702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="225" mass="26100" checksum="D3AF84798C1CD742" modified="2018-09-12" version="1">MPGLTDDEVVSELRKMTAFIKQEALEKAREIKVKADEEFSIEKAKIVRQESINIDATLERKKKQVEIEKKIAISNQNNKSRLQLLEKREELLEKVFDDARDRIGQATKDEKKYAELLKRLVLQAIFTIMEKDVKVSGRQRDEKLLKKAAKEAVEEFEKQTGWAPKFAIETDLNDKSAGGVIIKGYGSRITVNNTLDERLRLLEEKMLPELRESLFGKNENRRFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PG02</accession>
    <name>A0A2X0PG02_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C038g11712 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C038g11712</name>
        <name evidence="2" type="ORF">BQ5605_C038G11712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000061">
        <property type="protein sequence ID" value="SGY92037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PG02"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY92037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="441" mass="49548" checksum="D0B61752CC8062A6" modified="2018-09-12" version="1">MRQPLVTPLAIYISALKSGARGAPSTLASARRSHTCCPPCNPGCWMARGLGQLANEIDLLLGSLRSDARIRTNIPGTRHMVTYTARQIQQRTFDEHARGEASSPSPRPPMAPPIQADFDEAANPSGMDWDDERHSEYGGGHESDFSPAPYFSDRTSRMPIVPDYIATAERLSLADLRQVESFEPATRGQSKKETYKQFVFNDARLRSLERPALLRQYIAATVLKEYRTRIQDFDDILARIFTVPVDIAAEYEESRLFREILSPLYQECQRPLPEDEIRTDEDQEGSDRLFKMDPKGVPPFSRETYPGRVLGSVRKRTSHLASSAQTICNDGACQDLVLLLVHVPEPPKPPTDADREPERKKIWDSWIVECAHRWLALLSKQRETYRWMRKREEDAISEHSSATGQHSDHGSAAGSEAKSNLSALSELTSLSKLERGLDTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PH68</accession>
    <name>A0A2X0PH68_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C036g11520 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C036g11520</name>
        <name evidence="2" type="ORF">BQ5605_C036G11520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000063">
        <property type="protein sequence ID" value="SGY95841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PH68"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY95841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="205" mass="22363" checksum="EA9337B811C62491" modified="2018-09-12" version="1">MPLADATAILEFSRQPSEPPTLLAPEAQSFQPPLPTPGWFASRSPPQLATNEAQYGVPTSPKGPYSPQGDHGSERASSVGGSMGSSEDQALGLDEEDFRETQQFDAAFDWGMTFLLGKLRSLNLSRLEAVDAIERTPVAKPAQRRQKRKAAFVVSAQRHQNLCFTRGQGTLGAIEIIDLRCILGSAGRIYRRVGRDSRGASRVYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PMS6</accession>
    <name>A0A2X0PMS6_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 14">Adenosine kinase</fullName>
            <shortName evidence="14">AK</shortName>
            <ecNumber evidence="4 14">2.7.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Adenosine 5'-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BQ5605_C026g10122</name>
        <name evidence="16" type="ORF">BQ5605_C026G10122</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>adenosine + ATP = AMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20824"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.20" evidence="4 14"/>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ27555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PMS6"/>
    <dbReference type="STRING" id="796604.A0A2X0PMS6"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004001">
        <property type="term" value="F:adenosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01168">
        <property type="entry name" value="adenosine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000076">
        <property type="entry name" value="Adenosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001805">
        <property type="entry name" value="Adenokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769:SF3">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00989">
        <property type="entry name" value="ADENOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 14" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="15">
        <location>
            <begin position="21"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00068771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU368116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SGZ27555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="335" mass="36300" checksum="2CC3EDCACB6FC348" modified="2018-09-12" version="1">MGNPLLDMQLTGEAAHEMLTKYALKPNDAVLAEGKQNEIYEDLRKNYKVTYVAGGAAQNCARGAQYVLPNNSTAYLGAVGKDDLADQLRAANEKEGLASYYQVVEDKPTGACAVIITGHDRSLCTTLGAAESFSPSHLDTPKVKSLIDNAKFFYLGGFFLTHGLESALKLAKLAVQNDKPFTMNLSAPFIPQFFKSQLDQILPYVSILIGNEAEAESYALSHDWENPKEIKSVALKLSQIESKTNKKGRIVVITQGSEQTIVAKEGKIQLFNVAKLDESKIVDTNGAGDAFAGGFLGAYASGKSLEESIEVGHRLGVMNVQLIGPTFKFPKEKVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PPK7</accession>
    <name>A0A2X0PPK7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C079g12961 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C079g12961</name>
        <name evidence="25" type="ORF">BQ5605_C079G12961</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000120">
        <property type="protein sequence ID" value="SGZ34060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PPK7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="512"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="808"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGZ34060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1230" mass="135368" checksum="B0DBE6BF3F9F476C" modified="2018-09-12" version="1">MDDTSPPLATGVHPTFPADQLAALTSLLSGLTAAASGTVTTTTSSSTTRPAFPKHARLDGPKTFANWTRQLRLCLADDIRSYVLDGIVPVDWTPSQRSARDVVARELLANSIDSAEVSAVLDAIPTADLTAPKIYSTLKSRYAPDDATRTLELFSRLWSFRPMPGTVGEFDGWIMEFKAIAQEIIDTKTTINDVLATLLLAIAHPSLESFKASFTDEQRTQRSLPAIDSLADRMRVQLRSTNVPSTQSALLASSSSRPTRPKCLACHSPSHRVAECPVRAKHPPPGPCRSCKQNHWSFDCKKALENGKKADTANSTANSQHHLRTNSFVVDSGATSHMVSDKSLFTTYRHIAPTKIGGIAGGINAIGTGNIAFVAASGHPITLTGVLHTPGLFVNLLSVSRLCDTDDVRVAFTKHGIDIDKNGHNIAEGTRLDEGLYLLDADHSKCQHLALLSRSQSSVPLLTLHRCLGHLAPSSIQKMVAAGLLEGLGAGYSDEEVEKFVCNACLSAKGHRLPFPDSDSHSSERLGLVHSDVLSLPERSLTGKRYLVTFLDDYSRKLWAYAIGHKSEVFSVFKTWLAEVELETGATLKVLRTDNGGEYCSRAFTDFCKVRGTRRQYSIPRTPQQNGRAERVNRSIVEGILALLADAHLPKTFWEEAAAYFVYCKNLVQHSALDKATPNSVWQGGRTTASALHPFGCAAWLTVAPELRSKLDPKAVRVLFTGYDLASKAFRFYDTTTKKVTLGRNATFLDTEFPGLCGDSAEPDDDTHFASAPFADPQTTVKSWTPLYSADPLDLIGSQPQAALDPMDTQPPDFSTYREPASAEESPDELDLIGRHSRDESPDEIDFLTRHHRAFIATDDDTSDTEAIEPVKSITSDPQTWREAMSGDKREVWAKAAADEFNSMRDDFKVFTIDDRSTVPAGATIVSSKFVWKTKRNALGEITGHKARLVAQGNRQRDGIDFTETFAPVARFSSIRSLLALAATNGLHVHQADIDKAYLHGDLDHDIWMTAPRGFDLPGDKVLRLRRSIYGLKQAGRIWNRHIDASLRDLGYTATGTDHCVYSRLDDRQRPHYIALYVDDLLMISPDLAEIERVISGLEQRYGVKRLGPAEYILGIQIRRLDDGSIALSQERYIMDVLARFHFDTTTRGTTVPMTPGLSLTAIPGQATERIRSWYLQAIGSLLYISLGTRPDIAFAVSYLARFANNPGHRHWIAVKHIFRYSINSTTSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PPR6</accession>
    <name>A0A2X0PPR6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C069g12856 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C069g12856</name>
        <name evidence="2" type="ORF">BQ5605_C069G12856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000131">
        <property type="protein sequence ID" value="SGZ35068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PPR6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026960">
        <property type="entry name" value="RVT-Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13966">
        <property type="entry name" value="zf-RVT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase zinc-binding" evidence="1">
        <location>
            <begin position="76"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ35068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="235" mass="27107" checksum="4F4C4FD31AC28240" modified="2018-09-12" version="1">MSPALLPKTALRPARIPLKEAPRPRCFNFFGLTRPFTIRKLRRLVNVVRFPGREDRVKRFHGFMTGFASAVEQDTHWRLMYDVTPTRKRQHTQGHASSPTCLFCGNDAAVIETVSHYFFECAYSTSFWGGVLRILFDKLGIEDTDVDPSTFTPEQLTMGLPLLRGRGRTTSRWMWVRLACAIGFQRLHLLRWRVHQRFELDKVVAPPSLPSALRAFERDFLSRAGFVPGARDWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0PQJ1</accession>
    <name>A0A2X0PQJ1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C075g12924 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C075g12924</name>
        <name evidence="3" type="ORF">BQ5605_C075G12924</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000128">
        <property type="protein sequence ID" value="SGZ34823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0PQJ1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ34823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="529" mass="58784" checksum="9FC8ACB641143F05" modified="2018-09-12" version="1">MQAISRSVSTTRSSAPVQGPLAISFQNNSLLVTGPLTTYHLFTSTLSTTWHCIDRWQHVDATRDRGPPCHDDSGDQYELVEEGVRRSVDSGSGDDELTELTMQGIGSPYYASSKKSGLWSGSVRRLLVTVRRRMTGTVPVGSLMRDDELTELTMQGIGSPYYASSKKSGLWSGSIGVFPGPASLTNCLGASAPFLPHSRVCSDFYRIGSKAGLEKARALRQSQKGALALSSFYGIVLGLTIALTVQTIRLSATNSSYRAGGASIPLEDMYPASITDSHIAAWRLSDDASRLPPCGRFILTPFRAGGIGSNMLIMLRGAMFAKNFRIALLVDNSYGWGYGRLEYYFEPYTIDCVPLEDWYDEKKTIPLWNPGWRTANRIRFSIDDSTDLIDHELFYERESFELQRLQRALFNHTIRPSVLPPSYTLPRPLIPAFEEYAQLLPTLLKPVPAILDDVERVKAMMRIGGEHPTIAVQPEPDRNLEVMHGLYDRMVGCSSSQANPCYPLSPTARRFSIEKQPARHPPDDRGRMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LPC5</accession>
    <name>A0A2X0LPC5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C011g06516 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C011g06516</name>
        <name evidence="2" type="ORF">BQ5605_C011G06516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LPC5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY12468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="154" mass="16432" checksum="3863962D5D9CB518" modified="2018-09-12" version="1">MQPGVDAAWHMTLLPRQPVLLLPLPKSHLQAFTSRLLYNNLHGEQRGSRDVGSCSRSSSSAQSSSSPPALIADVAASNLEQSPKLSDNDAFARSSSAKPINTTSRKLFRTSGSVGQCANSAVRGPASVSRACRHWASLHDISRSSATFYEPGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LQU4</accession>
    <name>A0A2X0LQU4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C010g06183 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C010g06183</name>
        <name evidence="3" type="ORF">BQ5605_C010G06183</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS26 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000012">
        <property type="protein sequence ID" value="SGY14438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LQU4"/>
    <dbReference type="STRING" id="796604.A0A2X0LQU4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000004">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000010">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028934">
        <property type="entry name" value="Vps26-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12233">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 26 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03643">
        <property type="entry name" value="Vps26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="295"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY14438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="327" mass="38315" checksum="F67250CDF3053B0C" modified="2018-09-12" version="1">MASFFSFSAPLEVEVRLEAEDDRQQVQVKQDKDKRDKCPVYFDGESIRGQAIVRSRDGKPIKHDGIKVEFVGSIEMFYDRGNHYEFLSLVQELANPGELRTAQAYDFEFKNVEKQYESYHGINVKLRYFIRVTVSRRMADVVKEKDIWVHSFRMPPDSNNSIKMEVGIEDCLHIEFEYNKSKYHLKDAIVGKIYFLLVRIKIKHMEVSIIRRETTGSAPNQYNESETITKFEIMDGGPVRGETIPIRLFLGGFELTPTFRDVNKKFSTRYYLNLVLVDEENRRYFKQQEITIYRQDQRGQIGQPQQPAELGQSLKTNSRPELKPDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LS41</accession>
    <name>A0A2X0LS41_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C011g06321 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C011g06321</name>
        <name evidence="3" type="ORF">BQ5605_C011G06321</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY11922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LS41"/>
    <dbReference type="STRING" id="796604.A0A2X0LS41"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="764"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY11922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="826" mass="92012" checksum="E48EE02F8CE2F6EE" modified="2018-09-12" version="1">MRVVADHTSSGLNDGIQRSDCPTVYDTIIDFIRLLRWHRFSSKLLTDNSVLWKLDVSSAFKILVLSKRWQARQGIAIKRKFPDGSVHTWYHIEWRGVFGCRAMPFLWTRFMSLLMWAANNTFGIEHPLAYMDDAFGIDLVGSMVPFAHNGAIHIIPTQQAAMATLWGGLKIPFKLSQEKAPHGRCITITGIRCDLASFSVSLPEKSISDLITEIDAFLLEPTRHPTLRKWRQMTGWLSWALNVAPQARPYLTPLYDKIAGKKRSDAGVHINTSVAMALAAMATLLVGSPSLPLDAPSLTRWGLKDADVVVYTDACLSNKTGSGAGLGFWLRWKGTVHHYYCRPQRAYERIQFAETLTVVLALSIVVERSPCFHLTNFVVCATKPPSMRSNLKHDTLSAFIRHRYRTVSSVSQTLSGLAFTFRPRLGTEWEGARTSQLVTNTVVGGIKLWQRPRKQAKPLSSRSVAFALRTAVSNPRLDYDSLLFLAMVALGFASCARSAELALPSTIQFRDPAKLPRRSTVQMKDGGFSVHLPYHKADRRWQGLYLYFTCNTTNPVFITILRRYLYARDQQYPTSPLLFVTKAGLPPTRTWFVSRLCRAFGPSYNGHSLRSGGATHYALRGLPAEVIKRLAALLRKSRSLFGFCCKSLTLRTLARATSTPPAASCRKPCPHACLEHKPWPVSRTRAGISPSTLPPHWVSSALPVVAVPVFAAYLCHLLPRLDLPSDTNTQLPPSLLPCQTTTDSCPLPVLPYTRQCTSLPHIRLYLSVLLLTTVLAGHVGLLGYLALQTTLATQRASVQGRFPSFKCVTLSKQSVIFLSSSHPLNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LSB1</accession>
    <name>A0A2X0LSB1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C012g06915 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C012g06915</name>
        <name evidence="7" type="ORF">BQ5605_C012G06915</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000014">
        <property type="protein sequence ID" value="SGY16578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LSB1"/>
    <dbReference type="STRING" id="796604.A0A2X0LSB1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="entry name" value="Cytochrome-c3 Hydrogenase, chain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01358">
        <property type="entry name" value="NDH1_NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004739">
        <property type="entry name" value="PRK06075.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 49 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="HydB/Nqo4-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADH-quinone oxidoreductase subunit D" evidence="6">
        <location>
            <begin position="244"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY16578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="514" mass="57780" checksum="CEAB96B3192A0728" modified="2018-09-12" version="1">MLRAGLLKNTLRSSLAAPRASIVQRGLATEAHPTAANYSPSVEDLRHQTAQTILQERESGKSGSFRAFTVNFGVSRSLGISVELVGSRPPGPYIDPLSPLFFAQTQPQHPAAHGVLRLILELNGEEILRADPHVGLLHRGTEKLIEYKTYTQALPYFDRLDYVSMMTNELCYSRAVEKLLNIGQLERNAYLRGALQQVAIVLRTKPASRRVSDVPERAKWIRTLFGEITRVLNHLMAVLTHAMDVGALTPFLWGFEEREKLMEFYERVSGARLHTAYIRPGGVALDLPHGLLEDIFKWATAFHHRVDEFEEVITGNRIWKQRTVGVGLVTAQQALDYSFSGVMLRGSGIPWDIRKSQPYDAYDQVEFDVPVGKNGDCYDRYLCRIEEFRQSLRIIDQCLNKMPEGQVKIDDHKIVPPPRASMKESMESLIHHFKLFSEGYAVPPGETYSAIEAPKGEMGVYLVSDGSNRPYRCKIRAPGFAHLAGADFMMRHAYLPDAVAIIGTMDLVFGEVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LSG6</accession>
    <name>A0A2X0LSG6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">BQ5605_C011g06451 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">BQ5605_C011g06451</name>
        <name evidence="18" type="ORF">BQ5605_C011G06451</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="17">
        <location>
            <begin position="353"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="561"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="561"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="601"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="SGY12274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1419" mass="156476" checksum="3E756EAFBE8DC0C6" modified="2018-09-12" version="1">MVLVNHLQMAQLDLEQAIAARALDNLPPVFDSWLTTFYAVKVQDNKLPRVEQIFASMETVARTLRHDPTPALAAKPVATTKPSASGKKGRWDRSGPAPSNCPACGQGKHWVDKCPDTRKRVKYFELRNAMKELQGTSSLQAPAFVATEEASKDLDMSFFLSPTFVSFGAPNVFLLDSASAYHVVNDASFFNGPLSPTSHILQGLGETVKASGVGSVKLAPESPANLVSVRAFDRKGVRITFERGQAELRTQQGRIATASAIASHVYKLNASVQTPSPGVIHMFVTTNSHGIPLLTLHHRYGHASVQTLKKLAASGQVEGLDWTYSDLECVDFTCNACLASKAHRLPFPPLSFHASEPLALVHSDVLSFPEESFSHKRYLVTFVDDFSRKTWVYPIGHKSEVLQTFKDWLMEIKNETGRKVKTLRSDNGGEYVSTAFNGFCVARGIRRELTIPYTPEQNGRAERLNRSIVEGTLALLIDSGLPPLRAFGCRAWATVPAHRWDKLDPKGIPLVFVGYDRHAKAWRLLDPSSMRVSLSRNVTFLETEFPFVAVPARVTPPSVPGFYPRPPPADAPATPLPPVLVEPTQPPSLDNDATSSIHLPQRPPEPAPPEPAPLAKVKPTWEYGDVAKVGPDPGKYGEIDARNIIAGPRTRRQLVPTLITWEDLVGGPDGPTPAFQGMLRAFASTKAGFAEHNLSVVRDPANWGNVIRSGQQDTWGGPAHDEFDSLLNEYKVFVVIDSCELPAGEILLRSGWVFRTKCNQHGDIIDRKARLVAHGCAQHPGINFEQNYAPVVKFTSIRALIALAAANGYHVHQADVNKAYLHGKLDKPLYMRVPQGINMPGKILRLSKSIYGLRQAGTIWNAEIDSTLRSLGYVPTRSDICIYRREHDGHSHYIALYVDDLLLVGPSTAEIDRVLDALELAYGIKRLGPAEYILGIQVKRGHNGSITLSHNQPLHGYSDANWGACLTTSQSTMGYAFILSGAAIAWCSKREHRVAKSTTDAEYLSLLYASGDTIHLSELLSELGAPVPGPVVLYGDNQGSLALAQHPTNHQGSRHVCISEHYVRKRVAEKEIEVRYIATGDMFANIFTKALGPKPFIFHRTNLGLRGSNRYLDHLNEYVSYNIPSEEAAAAGDCVPDRTKTFSHKYYENELDVALGLFTDGLQLFDSGASSCWPIILVNYNLPPTLRYQKQHLIPVAIIPNPGQPKNIDSFLEPLYADARRSAEMGHVVFDRYTESSVRQRWYIHFVGGDGPGISKVLGFKGPNSKWLCRVCTNKGITGPKGRKNYYPLKSVTGSIRKIAWEVTTGRARLFKDPDMGMNGLARIAFIPGFGFHKDGALDFMHAAFVNIAKRLVNLWHPSKEDTAAQVAQGLEPDPWVIGDNVWEEIGLEMKACAATTPYQFLRAMPNIARTQSQMTAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LTB5</accession>
    <name>A0A2X0LTB5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C011g06442 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C011g06442</name>
        <name evidence="1" type="ORF">BQ5605_C011G06442</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY12253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LTB5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY12253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="109" mass="11406" checksum="2D47C6A280EAE21A" modified="2018-09-12" version="1">MNMNGSTFGSTDDLFSLTLNSDTASSFGAATAGDAPSVQQHIERVVGALSVLGRSATSRGVFPDARSIVLNACATPRKGMLRRACVIVALLLIIPDRYAYASQSDLSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LTL1</accession>
    <name>A0A2X0LTL1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C015g07913 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C015g07913</name>
        <name evidence="3" type="ORF">BQ5605_C015G07913</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LTL1"/>
    <dbReference type="STRING" id="796604.A0A2X0LTL1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF38">
        <property type="entry name" value="ARSENICAL-RESISTANCE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="22"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY17845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="175" mass="19199" checksum="7DF20A649C7A38B4" modified="2018-09-12" version="1">MVSYTFIDPSEVAQLYHSGLEPGRDFQVVDVRDEDRIGGHLPGSMRAPSEQRTLQSVQDLVVKLEGVPKVIFHCTLSQIRGPKAASLYCTALNERHDALNFESATSNSIIENSGTPLTATSTKDSTNTQAAQNFSPNPFELKASASEQNRSQQVLDDPKLVEGFDPSIWAEGKDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LUT2</accession>
    <name>A0A2X0LUT2_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BQ5605_C017g08380</name>
        <name evidence="14" type="ORF">BQ5605_C017G08380</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY19914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000007">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="12">
        <location>
            <begin position="644"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="13">
        <location>
            <begin position="1186"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="11">
        <location>
            <begin position="1498"/>
            <end position="1550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="64"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1523"/>
            <end position="1550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1540"/>
            <end position="1550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SGY19914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1550" mass="173770" checksum="969D10969C67E026" modified="2018-09-12" version="1">MPTPTAPSHSPTYKPNDPPQLHSTSMEALREYFMRLDFYNRRIARTPITSDYVKGTRLLSSLTGSESKLKGSNGVIRRRRKTTKRTKVKRRGGAAREGKREAAEIEGAGMGLQVFALKTWFTQGLSKHLAKPYTQFKSELIRRAVPADFVWTQLAELHRLRQAPGHNIDAFQEFSDQMRSLQMEIGFQVVSDQEVAKLVLLGTDPELCRILRTHMVSSLAGWSDLSLEKLALDAPVVPTSPEAAEVFSDAHTDQPLEFNYQVFERIGCEEWSVIAQRRQAIATQVGALQQRPTYSRPAAASAAPHVATAATGHSPITGGPRPVARLTVDERAYLDQNHGCYRCRTLNADHISRNCPRYLSPMGASATPSTPTLTAPVPRPGPRMVAAIRTFQETGDSTVFAGLSSNSEDDNDPSYAPHPFPPLPVSLAGAHGTLLASALVDSGSPQTFLSEELVQRLGLERRALEQHSKYTLAMQNQVPTVFTCTHFVRVLLELANGLWAAGPTYAEVAPLGKDLAIILGGNFIYRHKMELGLFPQPHLTCKANPIHAIDLLALSSQPCAAARVAAIAPVSDDEEQLRLAALDHRLRAEFADRFPADIPPVHLYQSPVRHRIELDTPSTVVNLRGYPLPKKYREAWYLLLQEHLAAGRLRPSRSAYSSPSFIIPKKGCDVDPTIAPRWVNDYRKLNKHTIKDRTPLPLPDDILSTCSNAQFWAKIDMTNSFFQTKMAEEDIHKTAVSTPWGLYKWTVMPMGLCNAPATHQRRVNEALQGLLGTICFVYLDDITIFADTLEEHEARVCQVLDALRRAELYCSPTKTNLATAECSFLGHIINRAGVHADPKKIQRIEDWSLPKTVKELRGFLGLVQYLRKFIPGLAEHTAALTPLTRQGLSSIATLWTPNEVRHFKAIKAIVTSLDCLRPPDHSANAAPFWVMTDASNQGIGGVLLQGQEWKVARPIAYWSRQYIPAERNYPTHKQELLAIVEALKEWRIDLLGGHFHILTDHSTLEHFQTQRTILSRQQARWLDTLAEFDYDLRYLPGEDNIVADAMSRYSFTDPLPTLVAAVSHIKLSDAVKQQILDAYKTDPFCQQAMSNIGSVTSDFKIVDALLYLRGRLIIPSLAPLRESILHDAHDAQGHLGDMKTYRTIQQAYFWPNMSRDVKHYVQQCDSCQRTKACTTRIAGKLHLLPVPTRPMADIAIDFVGPLPANKGFDRVLTITDRLSGYVRLLPARKADTAAEVAARFHEGWHRLFGLPQSIVSDRDKLFTSKFWTALHKRLNIKLQLSSAFHPETDGRSEKTDKTAFQILRALVNKEQSNWAECLAVCEYAINSSLNVATRKTPFELVLGYTPSLAPLARVDGDDDLPSVEELLALRFQACEDARDQLAISKVRQAAQSNKKRQDEPSWAVGDFVLLDSSDRQKRLHTRKRRAAKLMDRFDGPYRIVKAQPEISSYTLQLNGDDAAVPFFHTGKLKTYRKNDTALFPNREPARLGPVDVGGEPEYIIEDIVDERIRAGKQQYLVSWLSWPSDSNSWEPAEALEDTEALDRWERRNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LV78</accession>
    <name>A0A2X0LV78_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C016g08095 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C016g08095</name>
        <name evidence="3" type="ORF">BQ5605_C016G08095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY20566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LV78"/>
    <dbReference type="STRING" id="796604.A0A2X0LV78"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY20566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="547" mass="62150" checksum="6144401A551F9828" modified="2018-09-12" version="1">MPIPYVFGESPRVAISPAHNFRRRSSVASGSSPPRSPLIASHTPPTNKTSLRQPFISQLIYDEKSGEIDYPCSPPTLSSWPRKSSSESLEEKSSPTSSRFHLHAYGTRRRASPPKGRPFQLPRPWLSVIALISVTLSFVVLLTYLVPSSTPYTMGSAASALLFHKSTKCEPYSAFGALYTDTHDPDANRWVPFDEKCQAPNFLSKLRNDQTTADFSWLRNRTALIIGDQISREHVENFCILMGKESEVIRDDHKYNPGNAIFRMPAKAQHLGERPSRIAARSSKSAGRSLRDTSRPRMCYIPQYDFMLVSIFNFGLDQEDFWRDSEAPQYVAPGMFEHRLADVVEPVVRALRADGRASAPDFVEVTSGVWDLARWAQQDITAQQDTAGPLAKDRVTWYRFRVGQALEKVRKMFPDAKAKTWRTLHYPLDAQAEREYFFEKIAPRQRNSTALPEPPFFSHARINQLDEAVRSLLLPTEIGDLSLEAPHPDFRLNEWGTMLKGHEAHQLDRIHGDPLPGGYLWADVMLYELWRGVMHSERRSLRSGFHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LWN3</accession>
    <name>A0A2X0LWN3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C015g07808 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C015g07808</name>
        <name evidence="1" type="ORF">BQ5605_C015G07808</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000015">
        <property type="protein sequence ID" value="SGY17526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LWN3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY17526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="118" mass="12768" checksum="05855C07D94D208B" modified="2018-09-12" version="1">MGRPAAWTLRRSRPLIGSAPSVCINTPLLASMCKSLPNRGQRRCKDPFEALQLVISRLRLWAADDPVTIQEEDSSLGAAAAIGADSGTGLRRKELLNHDVGDESEGFGALNTAVRHCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LX15</accession>
    <name>A0A2X0LX15_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">BQ5605_C018g08793 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">BQ5605_C018g08793</name>
        <name evidence="18" type="ORF">BQ5605_C018G08793</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY26795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="17">
        <location>
            <begin position="349"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="631"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="685"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="722"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="SGY26795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1303" mass="143086" checksum="CF9F29433636CC11" modified="2018-09-12" version="1">MSDAGASAPEAKLREPTPDAPPLRPPTHSAAFATTELLRNSSGYRDWVLAIRSRLPSGVVRYLNTGVPLESWPASYVPLWDHYACSSICASVDSQTVLPGLSPYLDESLAAPKVWQALCERYGTVSAVDLLPVIQRLFSSDPVPVTPDLFLQFRDSFENDARLLQDSQVTVNALLASHLLARLPLSFDAWRTTFVADQGDSTAMPSATEIFTRLYRDVKARPVDTPVAAVATPQARHGCSRPCPNPSCRKLHWLRECPDTAWAAAYRARRTAEKKASQPVASPTPCTPKALLAVPANVSLLTLHRRLAHLPVAQIKNIVQSGLVTGVDWVYKDQELRDFYCNTCLASKAHALPFARSKSIASGRLDLLHVDVAQMPRPTFGGHRYMLVIIDDFSRKHWCILLALKSDVFPRLRDWILEVENATGNKVKTIRSDNGGEFTLRNFVDFCASKGIRRELTIPYTPQQNGRVERSNRTIKEGILALLYSSGADSRLWGEAALYYVHCKNLMPHAGIGGEIPDTRWHGFAPDISTLRAFGCRAWHHLPSAKRTDLDPKAVPLLFVGFDQHAKAFRLFEPSTRRIQLSRNVVFRESEFPALRPAPDVCAEPIPLPVPVDAYPDQVDPLEPSLVASPRSLAPRAEPPRPVPAAPDQGPHRPAPAREVPDQDSLAPPAPDQGSPALELPDPESPASSASDQGSSDSAISTPCPSPRPVASRALPAPPSPARSDSPDPIDLLPRPRDVASLCQAQEFPDDVDDALHSPSAVAYLASGAAALIETSPADPAELIAPARDPPHWRAAMATPQADEWRLAARDEFDSLLRDFSAFTPIDESLVPADAKVLGSRFVFRTKRDQHGQVKSYKGRLVARGDSQRSGIDFDETFAPVAKFTSIRALLALAAAHGYHVHQADIDKAYLHGKLDAPLYIRVPDGIYMPGKVLQLHRSLYGLRQAGRIWNDEIDSALSALGYVATESDHCVYVRTTGDVHHYVALYVDDLLMISPSLPEIERTLQGLEQRYGVKRLGEAEYVLGIQIRRSPDGSISLSQEQYLKDVLARFGMSDAHPVATPMQPDLRLEVELQPTPFPDRTRYLQAIGSLMYASTGTRPDLAYTVGYLARFSHSPSAAAWGAVKHAFRYLAGTLSHGLRYARGNPAPLLGYSDCNWGACVLSSKSTMGYTFVYAGAAVSWSSRLQSRVADSTCDAEYLALSHACKEAIFLRQLFGELGLSSSKPVLIYGDNQGANALTKNPVFHARTRHIRLREHFVRDMVSMGDIVVQYINTGEMTADIFTKALSRDLFARHRGRLGICAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LXA2</accession>
    <name>A0A2X0LXA2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C081g12978 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C081g12978</name>
        <name evidence="3" type="ORF">BQ5605_C081G12978</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000036">
        <property type="protein sequence ID" value="SGY28365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="983"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1580"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="351"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY28365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1824" mass="201276" checksum="D90FB27C62B38FB1" modified="2018-09-12" version="1">MTLPARLRRRRLSHELPKGRYETTRCGLQRDPSHHGWYWVPRGPVQIALRKHFGLAETPFMFARPEGAELDPEVEKLFSKCVKLNPIVTKATKRFPIARHMYELVFESDQACLEAAAAGPFPYHGKEMVTELPSVSPLNHIVQVRFTLPSSSSAIPASVLRKSLDAALTSSFGHAGCTQGYTLMQLQRGLAVDPNGDPMAMTEDGFHCAYLRLHADLFQGSTETQKAALNAALPQEIEILGANGGLQEAGFDSGHRRPCSGASTSTSTSTTGFRVAGKNGKHGGPAALNSRASGTNMIQLGPRANPASAATGNKDDANDGDGDDDDDDGESVASTEPEGGDAGKETLTRATTGPTKETQTKTAAPVSTPTSPSPSTSAPASPLSGGTSESSATSTTSIASTSPRRLRSSSAPGNRRVTRAGSAMIHGASGGDDSGGNSSGGYRSESLTVLTFNVRSIKNAVNQVKIIRYLKTLRPAPAAILLQEHHLSYNALREGFESAWPGACIRFAPHVLTLIPDGSPLAGRLLSSTPVVFAEAPQFDGRILRSVFRLEELDIEIINMYAPVKGEERRDFYGLLHFTAPGPKTLRILAGDLNDCPDVSVDRVAITDRAWTPVSHWQTLLSKIAFNPLDTIRQLHPITPAFTRPHYLGRGDKREICSWSRIDYILVQRSWANRLLSASTLFDAPCSDHRPVVATFALPTSNAADAEPPPALPTTSEFISRLNPTVFNDQDFVDSIPGVVDEVYRRLEGTAPLGDVYDAALRAVAAAGHARYRSTRADMRRLRAENQSVMEALEARGEHMNEAERDAYALAKSQLDQLAVKEAQWLRIRAHVPSVDSREGQSASIRTRLNRRSRQTSIVSLEDVDGTETVDMQEALGIASRHAQSLFMPDPARGDPTNARRSLLDPIRASKCYDDDRSDPTFGRRLPLQARVALDEPFNLSEVEAALKKTDSGRSPGPSGIPYELFKALPTYFAPKLLDLFNSIWEGGKMTASLAEGLVRLLPKNKPGANLKSLGAYRPITLRETTYKVLSKVLVARLNGVLGELLPPAQHGFMPSRRSADAGSHLTLLLEKLKSLGTEVFPEGALLSLDQQSAYDRVDHAWIFDVFEAFGFGERFISLLRALYDPETLGVRYLINGFPTELVRLLCGLGQGDPLSCPVWNITFQPFLDALVRRGIALDLQKVWPGGPRAQLTHLAFADDAVVVVESPAALSKLETLSQTWYEATNGKTNTDKTLVLPLGPNWLRDETAQALPTVQEGESFKWCGYAFFRHGDSKLFWTHVLDRIKAKARAARDRTLSPSGRVFYANAHITSTVLHVLSFDIPPQRFIQAAETALTDFVWGGPRRNTVARDFVFQAREDGGLGLISIGDIVHSVALRFWDAVAGSDEAIWAPLARESWRSLVAATRDFSPWGFFSSTARVEKLYRDSARWGAVVAAARVTLPTIKSELLTLPELLSLPPRLPSLYAEGAKHAYDDADAVAKFAQIADLYWRDEGKGWALVGHRRGFWQHSKEPALRHEHVWARVGQKLKAKALLPKTAVRPARIPLKEAPRPRCFNFFGLTRPFTIRKLRRLVNTVRFPGKDGQDRALPGGQPQEPRVKRFPEGTSQSGRQRFWSWLHDRFASAAEQDTHWRLMYDVTPTRKKQHVQGHASSPSCLFCGNDAAVIETVSHYFFGCAYSASYWSGVLRILFDKLGIEDTDVDPSTFTQEQLTMGLPLLRGRGRTTSKWMWVRLACAIGFQRLHLLRWHVHQRFEKDRVVAPPSIPSALRAFNRDYLSRAGFVPGARDWEKARSFYWIVFCRLPTAQQPALETQPRRDIRRCRGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LYQ3</accession>
    <name>A0A2X0LYQ3_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor 1-beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C014g07642</name>
        <name evidence="9" type="ORF">BQ5605_C014G07642</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the EF-1-beta/EF-1-delta family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000016">
        <property type="protein sequence ID" value="SGY19416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LYQ3"/>
    <dbReference type="STRING" id="796604.A0A2X0LYQ3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005853">
        <property type="term" value="C:eukaryotic translation elongation factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00292">
        <property type="entry name" value="EF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.60:FF:000001">
        <property type="entry name" value="Elongation factor 1-beta 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.130:FF:000001">
        <property type="entry name" value="Putative Elongation factor 1-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036219">
        <property type="entry name" value="eEF-1beta-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018940">
        <property type="entry name" value="EF-1_beta_acid_region_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049720">
        <property type="entry name" value="EF1B_bsu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014038">
        <property type="entry name" value="EF1B_bsu/dsu_GNE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001326">
        <property type="entry name" value="Transl_elong_EF1B_B/D_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595">
        <property type="entry name" value="EF-HAND AND COILED-COIL DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595:SF21">
        <property type="entry name" value="ELONGATION FACTOR 1-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10587">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00736">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01182">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00888">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54984">
        <property type="entry name" value="eEF-1beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00824">
        <property type="entry name" value="EF1BD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00825">
        <property type="entry name" value="EF1BD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Elongation factor 1 beta central acidic region eukaryote" evidence="8">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange" evidence="7">
        <location>
            <begin position="152"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="71"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY19416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="238" mass="26137" checksum="C0A125778591B2CE" modified="2018-09-12" version="1">MGFPEFSTPAGLQSLEAHLQHVSYIEGYQPSQADVAVFKALPSSPDATMYPHSARWYKHIQSYETEHVTLPGDASKPHTAYGPSSSASALAPEPVEVTEAKAKAADAEDDDDEIDLFGSDDEEVDAEAEALKQKRLAEYAAKKAHKPKTIAKSVVTMDVKPWDDETDMAALEKSVRSIEKDGLVWGLSKLVPIGYGIRKLQITLVIEDDKIGLDDLQEEIAEFEDYVQSSDIVAMQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0LZI9</accession>
    <name>A0A2X0LZI9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C017g08504 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C017g08504</name>
        <name evidence="3" type="ORF">BQ5605_C017G08504</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000017">
        <property type="protein sequence ID" value="SGY20165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0LZI9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY20165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="230" mass="23864" checksum="98A33C55C15BC795" modified="2018-09-12" version="1">MSSGVLTSISRTTSPFSSGFLPSSTTSVNNSNNNNNNNGESTGLGPTIWYYVVALAIVTLLLSTIGSRVFLMRRRRRLYGPDARCSLPRPTGTGGGATTIGSGGRLGGIPTYRPDNGELESGLPTYCETTTYSYTSGLPVGSVAANSTNPFDASRAVPADHPMYAGPTIPVGAFTRNEGGVERSGMGMGLPAYTAPTTTTEGHTNGLTTTGQGNVTLNQVATPEPPKYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M0D0</accession>
    <name>A0A2X0M0D0_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C016g08262 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C016g08262</name>
        <name evidence="3" type="ORF">BQ5605_C016G08262</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000018">
        <property type="protein sequence ID" value="SGY21668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M0D0"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053209">
        <property type="entry name" value="Gramillin-biosynth_MTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643:SF2">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="394"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="884"/>
            <end position="908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY21668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="908" mass="100869" checksum="0D556E0DFB43F2BC" modified="2018-09-12" version="1">MDPPEPLARGELNSARSELRFLERLRAMELYEQVGTEGAFSNVVESRRILLKIMALARSVYAHPSLVDDTVEQVKYGAVAINSAAMTDRYKAADIKDALKAQHDGKSIYLLARIISRPHRNQGDVAFAFEDQSGAAAMMRVSSWPLGPTATGPELDLLFPLGQIVAIKRLRRFFRPNETYFICPSPTDVVMLELSHPLVRGSATSWSGPAPGPIPSLNDDYKALGNAAFARKQWRGAIKLYSTGIDLVTHANPVEPIERLVLLHNNRCAAHLKVDNLRQAHQDALKVIELVENVSPEGRLEIGPKTIQDWLEKAWRRRAVAEERANNLELALASYKQVLAFGRSLKGEAQQGIARVELMLEQSRTGKHYPWLELYERSLKPEEDPRMPVGNYIGPIRVVDKVEGRGIRGVIATSDIQVGELILAEKAFASGYAVSSLSKGRTSLSQQKALYHNMFISRLIDDPTLIETLAPLHHGRDAEMAALSATPGSQSFHADFRKPYTPVGGEFDLDIDSADLLIAQVSQVAASRNSCRYFPVCSTELLTSDSASLDRSCGFQVVRGPEDLFPPRPIMPEDEAEQRLDTVMLGACPYLSLINHACFPNVTVAARFGDLTFVRAREFIPAGVEITMTVSTTIYEHATRRSLREEAEENGVGECGCRCCVDDKLDGASRLSLRKGLFDSASMALVFEHFEEPLDLDTRVKRLRKLVNALEATYRPGHSRVRPELAEPLWELAEATFVQQTKVAAGRLGVIHRLRHSPSFIFPLSIIGLFKRALVAMGCQMTLTGPAAEMDPLREDAQWSSNCKIQVQALGISSDVTTLLCLCLHMFTTMRGDLHADESRAWLQAAVEVENLTFGTRGVEFFKKRWENAPMLRRPEVRRHLQDLARQDPITTGNTHRGGGSSRGRRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M1M1</accession>
    <name>A0A2X0M1M1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C003g02435 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C003g02435</name>
        <name evidence="2" type="ORF">BQ5605_C003G02435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY40876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M1M1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015959532" evidence="1">
        <location>
            <begin position="20"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY40876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="203" mass="22881" checksum="792E28E983D5A4B6" modified="2018-09-12" version="1">MHVPFWAFTALSTFPPVDAIAVLPTRELTGGTRNARSLLGLHCVVDVSLPASAAAFTTCRDRCVPHSQDYLPADEVADREFHLAGRSQLLAARYETLDLAPLEPCAVLCTNRAPTVFIECLAFVAKLPILILPTILVYHQEVRTLFRLDQSLAIFPRRLGFHRLRYLFNNSYTTNVWSGESSSQQPSFRRWARSAPELYYVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M251</accession>
    <name>A0A2X0M251_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C002g01040 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C002g01040</name>
        <name evidence="2" type="ORF">BQ5605_C002G01040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY29312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M251"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY29312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="72" mass="7834" checksum="25767DCBEB528655" modified="2018-09-12" version="1">MACVVKHGKPSLFITVMCNPERPEIKAAARGPNDKTCNHPDIIARVFEAKLDRLCDDVLGNQQRAAVSAMNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M2Y9</accession>
    <name>A0A2X0M2Y9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small ribosomal subunit protein bS18m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BQ5605_C002g01551</name>
        <name evidence="5" type="ORF">BQ5605_C002G01551</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY33806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M2Y9"/>
    <dbReference type="STRING" id="796604.A0A2X0M2Y9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_bS18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_bS18_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SGY33806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="199" mass="21758" checksum="44686C102CD86FC7" modified="2018-09-12" version="1">MASLFSQVTRRAILSPSLFCSVGPSSLVSSSSRGFSSTSATPKPSVEKGPQGHTQQMTDLLNEVDFDGSIQDPSNLLNHLSSKELHVISPSRLSPRYLLIPYLPQPDRSLAYPLGPPKSEALRLDPFVRLNIDPLASPMNPYLRSEYCTSMGKIKGRGKTGLQRKSQRRMGKAVRRARSMGIIPTFGISLPADGSYRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M325</accession>
    <name>A0A2X0M325_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C002g01380 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C002g01380</name>
        <name evidence="1" type="ORF">BQ5605_C002G01380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY32556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M325"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY32556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="85" mass="9268" checksum="4B6BABEF38CD32A9" modified="2018-09-12" version="1">MLTDWKVITFDSCEPPGASRCPIVDDTGLSELVLHLLRDQYIKVSSARPPELDPSLLPSGPPAAQIFPLFFAKPEVCNAEVVTDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M3D5</accession>
    <name>A0A2X0M3D5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BQ5605_C001g00453 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C001g00453</name>
        <name evidence="7" type="ORF">BQ5605_C001G00453</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY46629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M3D5"/>
    <dbReference type="STRING" id="796604.A0A2X0M3D5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017351">
        <property type="entry name" value="PINCH-1-4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24210">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24210:SF0">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="600"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="15"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="185"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="383"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="732"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="303"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="320"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="337"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="385"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="412"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="740"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="762"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY46629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="773" mass="82490" checksum="B673D8121ECC304B" modified="2018-09-12" version="1">MTSYFSRLAPDLSRSKPSINLAIPGSTSSSSSSSASRSPLPSPSRLLFGRQATSTIPIDPSDTEENRDLEDNKIKCSDCHAFMDVTQLGEHICSESPPSTGTTMPSHSTAEVVLPFSVSRLANGLKRQVPDGLRIDVTATKPSESVGASTGGTTATHVPLGPKGAVVQSGSQSGYLSAEVNKSNFDASQPATPNYLPRSPSTTSVSSSSSNKLPFFEKYQRLNTPTASSSPTTTGLSRSPNSDDLAARANSRRPVCPTTSAHLPTPEATGGMYSLPNNGSSRSLASAGALSVGLGSGRASATRDPSPQPSVRSLQSNESRSSDARPRREKSNITAASSVLSSSPPRSMRIVVDERRIVPAEELPSPDHDDFFSAYDDHRRATLKASHSTPNDLAYYGQTNPAHVPKPKPTPLKQSSLQSRATPELDSSAQSTPAISIGTTRSKGSSQSLDDCLEDLRLMTESDDEEEYDPISSEYYDRRLTCSGPFDEDIELERTPKVSTALTQSRSTPALSSSAALASIVGSGSSSTRAPHSSSSRNGSGASISAYKPTSYLPRGFSSTTAVKSCTTCRRDLSHDLKNIQKAGDGQVFCRSCYAERFLPKCRKCCRAIEGGAVTSSDGKVLGKYHKDCFTCFTCSVPFPDGDFYVYDHKPYCQMHYHKLNGSLCANVRCRQPIEGPCVSLVGVENGGGGRYHVDHFVCSHQTCGIALLEHHFVVSGLPFCERHAEALPPRLPMAPTAGFSRSNPLAGSNGRSNPPPASTTRAKKRQTIITRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M3R1</accession>
    <name>A0A2X0M3R1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C002g01751 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C002g01751</name>
        <name evidence="3" type="ORF">BQ5605_C002G01751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000041">
        <property type="protein sequence ID" value="SGY35312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M3R1"/>
    <dbReference type="STRING" id="796604.A0A2X0M3R1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026894">
        <property type="entry name" value="DnaJ_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44924">
        <property type="entry name" value="DNAJ SUBFAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44924:SF1">
        <property type="entry name" value="DNAJ SUBFAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14308">
        <property type="entry name" value="DnaJ-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="88"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY35312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="474" mass="52019" checksum="C85F75D79762619A" modified="2018-09-12" version="1">MQTVQSRLKEAYITVTCPHCRTQVEYLNPTPTESTLKDGFNLACAKCNQTWIIKPGASSSSSSSSAHKSGKEKAKRRIGTDERPLDMTYYERLGLPVTCTTEDVKKAYRRLAIKFHPDKNPDDPSAAERFKEIAIAYTTLSDPGLRHAYNEFGKGKGDGGGQDGEAMVDPEAIFSQLFGGERFQDIIGTISLGQDMKAAMQDEDEEEVDTTPKTHDPSQPPPPTPSPEEIEAKRKKKEAKAEAEKKVAEHKEKARQERVKNLVERLKTKLALFSEQAQGEEDEQIASGVRTMWTIEAEELKQESYGVELLHTVGFVYKSKSQHYLATTGIIPFGVAGWFHSARSTAHIIGQTVSTVRSAYALKDVFEAISQAEKSGLSDEKKKELEDKAAQMGLHALFKGAKLEVESVIREVCDTVLAEEGVPMAMLRKRAVAVGILGEVYESVKKDAHSNPPIRGGAPFANLGGVPPPAARGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M3Z7</accession>
    <name>A0A2X0M3Z7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">BQ5605_C003g02004 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">BQ5605_C003g02004</name>
        <name evidence="18" type="ORF">BQ5605_C003G02004</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY38345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="17">
        <location>
            <begin position="349"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="630"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="685"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="722"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="SGY38345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1303" mass="143237" checksum="A40609B1E8BA0E62" modified="2018-09-12" version="1">MSDAGASAPEAKLREPTPDAPPLRPPTHSAAFATTELLRNSSGYRDWVLAIRSRLPSGVVRYLNTGVPLESWPASYVPLWDHYACSSICASVDSQTVLPGLSPYLDDSLAAPKVWQALRERYSTVSAVDLLPVIQRLFSSDPVPVTPDLFLQFRDSFENDARLLQDSQVTVNALLASHLLARLPSSFDTWRTTFVADQGDSTAMPSATEIFTRLYRDVKARPVDTPVAAVATPQARHGCSRPCPNPSCRKLHWLRECPDTAWAAAYRARRTAEKKASQPVASPTPCTPKALLAIPANVSLLTLHRRLAHLPVAQIKNIVQSGLVTGVDWVYKDQELRDFYCNACLASKAHALPFARSKSIASGRLDLLHVDVAQMPRPTFGGHRYMLVIIDDFSRKHWCILLALKSDVFPRLRDWILEVENATGHKVKTIRSDNGGEFTLRNFVDFCASKGIRRELTIPYTPQQNGRVERSNRTIKEGILALLYSSGADSRLWGEAALYYVHCKNLMPHAGIGGEIPDTRWHGFAPDISTLRAFGCRAWHHLPSAKRTDLDPKAVPLLFVGFEQHAKAFRLFEPSTRRIQLSRNVVFRESEFPALRPATDVCAEPIPLPVTVDAYPDQVDPLEPSLVASPRSLAPRAEPPRPVPAAPDQGPHRPAPAREVPDQDSLAPPAPDQGSPARELPDPESPASSASDQGSSDSAISTPCPSPRPVASRALPAPPSPARSDSPDPIDLLPRPRDVALLCQAQEFPDDVDDALHSPSAVAYLASGAAALIETSPADPAELIAPARDPPHWRAAMATPQADEWRLAARDEFDSLLRDFSAFTPIDESLVPADAKVLGSRFVFRTKRDQHGQVKSYKGRLVARGDSQRSGIDFDETFAPVAKFTSIRALLALAAAHGYHVHQADIDKAYLHGKLDAPLYIRVPDGIYMPGKVLQLHRSLYGLRQAGRIWNNEIDSALSALGYVATESDHCVYVRTTGDVHHYIALYVDDLLMISPSLPEIERTLQGLEQRYGVKRLGEAEYVLGIQIRRSPDGSISLSQEQYLKDVLARFGMSDAHPVATPMQPDLRLEVELQPTPFPDRTRYLQAIGSLMYASTGTRPDLAYTVGYLARFSHSPSAAAWGAVKHAFRYLAGTLSHGLRYARGNPAPLLGYSDCNWGACVLSSKSTMGYTFVYAGAAVSWSSRLQSRVADSTCDAEYLALSHTGKEAIFLHQLFGELGLSSSKPVLIYGDNQGANALTKNPVFHARTWHIRLREHFVRDMVSMGDIVVQYINTGEMTADIFTKALSRDLFARHRGQLGICAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-05-29" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M494</accession>
    <name>A0A2X0M494_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C001g00770 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C001g00770</name>
        <name evidence="3" type="ORF">BQ5605_C001G00770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY49335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M494"/>
    <dbReference type="STRING" id="796604.A0A2X0M494"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815:SF3">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015840077" evidence="1">
        <location>
            <begin position="23"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="11"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY49335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="249" mass="26800" checksum="9F936B60DA09256D" modified="2018-09-12" version="1">MKVTVVLTAALALASGVDVATAATFSSKQVKQLTGKNFKRLVQGSPKLTLAAFFAPWCGYCKKLGPEYDRAAENLKGLVNLVAVDCDAEENKFFCAAEGVQGFPTLKVYPGGSAPPSSYDGAREAKPMVDYLTARMPTFVKRATALQEVEALKAKAQDKPISLLFTAAASVTPMYKALSADFHKTLDFYAAREAKVGKEAMALFGVDKVPALLVLDGDKVTKYDGPLKYDALNAWLKPFATKKGKKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M4A9</accession>
    <name>A0A2X0M4A9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C001g00763 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C001g00763</name>
        <name evidence="2" type="ORF">BQ5605_C001G00763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY49285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M4A9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY49285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="101" mass="10934" checksum="27CBACA27D776188" modified="2018-09-12" version="1">MHNGCQSKAFDCNTPRRSAHRSDNDKITGPKYVGLTLDTLQTKNAQARAPPPSKAQAHGPYIDPVADVKTDADAQASAWLWEQVALPHLSLSLSLSLALAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M4G8</accession>
    <name>A0A2X0M4G8_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">BQ5605_C003g01932</name>
        <name evidence="23" type="ORF">BQ5605_C003G01932</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="FQNC01000042">
        <property type="protein sequence ID" value="SGY37976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032549">
        <property type="entry name" value="DUF4939"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13650">
        <property type="entry name" value="Asp_protease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16297">
        <property type="entry name" value="DUF4939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0229">DNA integration</keyword>
    <keyword evidence="16" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="21">
        <location>
            <begin position="1218"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="22">
        <location>
            <begin position="1767"/>
            <end position="1926"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="20">
        <location>
            <begin position="2068"/>
            <end position="2129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="289"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="849"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1601"/>
            <end position="1621"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="566"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="849"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="879"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1603"/>
            <end position="1616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="SGY37976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2271" mass="257744" checksum="A3C40DF3AD839384" modified="2018-09-12" version="1">MCTRRRYTRPVPSPAVARPEAFARGTMEGDRTFGLVLVNYYCLILSIVLEHGCTRCFQFFFDNDQDTRRPPPSCRAQDERTARPRWKLHAPSYLCRTDRTLSGLRLFWSRNDRYFKKEKIETDVDKIDIIGQLLLDPELKVWYSSDAASHVNKKYGVFQRDLTLRALPSDYMWQHYRRLDNLRQTGDYREFSTAARDLQLELGVSLVSDTQLVRMLLLHMDEELSQRLRLSEVIKGTGLSPDELDASIVKADSTTSSAVFDYQTFDAEARRLWQVISATRASVKATAQASARTVRSTPTLRTTASPSTLPPLSSKTRAPPMTDRERAFLRSNQGCFKCRKINAGHFKDTCTTWATSACKVPAGWRQGPVSPEQVASLSDAVDEIDDKGEELHCLCDDEYDNGTDDERCEPISLSVKLTTEDGPALRALVDTGASASFIADREVEKLRLTRRKLQVPTSVSVAIQSHRVSHPVTEFVCVPLRTLNGRWSTHYLYDLAPRSLPLASTCFHEFLSLSLGFPATINRASYSYKNNYINPASRPVILAIACCLRLSNLNPDSRSRFPIDLVDLTQASLDSLIDQLRTLQARNQALEAECRSHLSDKENYQITVTALANQQQTLSDFAKVVVDQQKESIDVIKSGLANLNVTAPANTTITPVKSQLAKPDKYDGKEKVKFKTFITQIKFYIFGNPSSFPTDESKIAFIISHLTGDAFQHFEHAINAKDDSKPEWLTNYQKFLDQAELVLGDPDYRNNLTRQLMSLVQSGPASVYASKFTQISSQLDWNQAALIAHFHKGLKLDLQAQLALHDDPQDLQSLIELAIKVDNKLHLARHRTNASTQFRQTNWQYSHSVNSPLRTSPVSQLQANPSTANTSGPAPMDLDATRSRRGPLSEEEKLRRRTNRLCMWCASDQHLRDQCPTAPPMIPRHTALNASPRMSCTGTLFPQVSSPPSPRYSQQNSTRFPKTTLFCPSYSISSPHPDLATSFVHDNHLQLIAHPTPIPLYVIDGRPIQSGNITHFVHLEVQFNGHTQSLRADVTQLGTYPLVLGMPWLRLHNPIIDWKRNTLVYSCQSCALGHTQPINVSIEGAPLVPLDHKHLDISFASSFAFERLVNNSDNHHGLLFYDPTSHQLSSSSPAPSQSLSDDNQDSLEYLESLKNLVPSEYHHLLAAFSKVKADQLPPHRKFDLSIDLEDNTTPPFGPLYPLSETELQTLSSWLKENLSKNFIRASTSPAGAPVLFVRKKDGSLRLCVDYRGLNKITRKNRYPLPLIPEALDRIRGAKIYTKLDLRSGYNLVRIKEGDEWKTVFRTRYGHFECLVMPFGLTNAPAAFQHLMNSIFRDLLDVSVLVYLDDILIFSGDECQHTRHVQEVLQRLINNKLYCNPKKCEFNRTSTEYLGFIISPSGVSMSQDKVKAITSWPTPTSLKELQQFLGFCNFYRRFIEGYSRVIAPLTRLLKKNTPFLLDSAALSSLDRLKQIFTSGAILCHFNPLLPSIIETDASDFAISGILSQVTDGHLRPVAFMSRKMLPAEQNYEIHDKELLAIVECIKIWRHYLEGSQHPFKIYTDHAALQYFQTKRVLTRRQARWSETVNHHKYTIEYRSGSKNNKADTLSRRPDFSEGGKASEQPGQILLRPYTLAASLVKFSPPSDIVDLIKFHLSQDPVSNQIVNDLNHDSTLHPYFNLQDNLLLHHDKIYIPNAEPLKVKLLAQAHDSLLSGHPGQVKTFELLDRNYTWPGMRQFVNNYVKTCDSCQRNKPTHHRKHGHLQPLPIPSKPWSSLSMDHIVDLPPSSGFDCVLVVVDRLTKEAHFIPTHKTDSSRDLARTFLTHVFKLHGLPTDIVSDRGATFTSNWWSEFLAMLKIKPNLSTAFHPESDGQTERTNQTLEHYLRHFCNYLQTNWSELLPLAEFAYNNSFHSSIGASPFYVTRGYHPRLEVSLRDSFVTDVPKYLQHLRSVQETARKQILQAQETQARFANLKRKPSPPFKIGDQVLLNRKNIQTSRPSSKLDSHKLGPFRIQRIISPVAFKLELPASMKIHPVFHVSLLEPYQANSLASRCSNPPPPPEIINGEEEYQVEQILDSRNNRRSRRLEYFIDWTGYGPQDRQWVSAADFDDDDSLVIEFHTRHPHKPGFERIQGLNGARASSYLYDLAPRSLPLASTCFHEFLSLSLGFPATINRASYSYKNNYINPASRPVILAIACCLRLSNLNPDSCSQDTRDRRLRFKTGHRKSAKLFDRFEGPYKFIAANVATSNYTLQLSEGDRSHPTFHISKLRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M5S2</accession>
    <name>A0A2X0M5S2_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C006g04039 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C006g04039</name>
        <name evidence="1" type="ORF">BQ5605_C006G04039</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY55517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M5S2"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY55517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="69" mass="7897" checksum="EEBBE56C7DCB419C" modified="2018-09-12" version="1">MPEHSLGTHQAAEETGTSVAEVIILFRTVLGLELIGCWRKMRCHFTGIFLCGFGMQRWTSVQRLFRVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M6N7</accession>
    <name>A0A2X0M6N7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C001g00218 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C001g00218</name>
        <name evidence="25" type="ORF">BQ5605_C001G00218</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY44926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="436"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="675"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="779"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="684"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGY44926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1323" mass="144478" checksum="9E6E5652BAD6C36A" modified="2018-09-12" version="1">MADIKLVHTLLDTTLNSIIPLTRAGVDSGAKVFVAAILRKDTLEPCMVATNTETDSPLMFSPYVQNFYTQISAESRPKAKDTIFFATHEPCSLSTKKRATHSRSLTTSTSVLDAGPPPSGVDAFEKYQANTIELFNTLSGYNLTFDQVISIRLIHFGKDLYKEYYTQALRQDLDKLPDPIEALQTLQTQAESTPAHKPVAMVANLTATDRSSSTPSAPCRHCGGPHWNRKCPVKDKKSKASSAPSASLAAAPDISTLVDGPVRGYLTAAMSTLAKPSLILDSGATHHIVNDRACFTNFRKCKPAPLEGITGEAVNSIEGVGSAVVRSFDGSIGQLHHALFVPSAPVSLFSASRANAAGYDINLSRGKATVSVDGSICHTGEITNGLYHMHASLVDVTTLIEQPVNMEVALNADLKCDTCQAGKITHHPFPTVASNRSAQPLDRVHMDLLAFDGAVSLGGAKYALVIVDDYTRYLWAIPMSHKSDTFAAFKSWLAKVERSSSRKLLAVRSDNGGEFLSNEFSSFLEEQGITRQLSIPDTPQQNGVAERANRSITEGVRSMLHQSGLSHALWAEALATYVYVKNRSPHSANSGVTPHTRWHGSKPSAGHLRVFGCRAWKAATTEARSKLDPRGIPLVFVGYDLESKGYRLFDPATRQVFKSRSVTFFEDEFPARREGITAAHAPVDDDDDDNDDDDDEVVVLPDQHANQAPPDQAELPAALRFDAPGPAWQPPVGSRPRNPPARYGALASLRSTPSAFAFSLGKEVTELVADLEAAGIDTSTANRPLSEPEDPFSLPSSDPTTWNEAMRHPHAAAWKAGAIEEFRSMKDDLKVFSVVGLSSVPKGATILPSRHVFRTKRDKAGKMVSLKNRIVAQGCAQGPNSFNNTFSPTAKYTSIRTLIAHSASKGHHIIQADVDKAYLHGVLEEEIYMRVPTGIEGYEGKCLRLHRSIYGLKQAGRVWNDTINATLASLGYRRLACDECIYRHEDAGGDHYIALYVDDLLFFGPDLGEIDRVLDQLDTLYGVKRLGPAEWVLGVQVVRHDDGGISLLQRQYLLDVLARFNMSDCNPCKSPMEANLQLSPEPDTDSADNAIYRSMIGSLMYAVVATRPDLAHSVGYLSRFVGKAGDTHLEAAKRVLRYIKGSLDLGIHYTRTSAPLLGYEGYSDSDWGSDIQTSRSTMGYLFKLAGGAISWSSRLQPRVACSSTEAEYLGLSHAAKEAVFLRSLLTKLGLDTSSPLRLLGDNQGAIALTQNPVFHARTKHLRMLEHFVREHVRNGEISVTYIPTHDMVADIFTKPLPRVVFQHHCDAIGLRRISSQEQGGVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M832</accession>
    <name>A0A2X0M832_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C006g03755 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C006g03755</name>
        <name evidence="2" type="ORF">BQ5605_C006G03755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000044">
        <property type="protein sequence ID" value="SGY53400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M832"/>
    <dbReference type="STRING" id="796604.A0A2X0M832"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY53400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="416" mass="46457" checksum="856A07EE3525B435" modified="2018-09-12" version="1">MTTIQPILALRHVYEPAVQLCRTDSVVSAMANSTLAHVSIRDDLGPQTAVCTHCKARHWECERSKSTRHFSACCSQGKVRLPPPPQPNLEYRQLQGSDSGQLLRPTTFVCTFRENARSYNNALSFTSLAAHWDQTQVGTLGPPVFRTWLIDPAEATNTRLQGPDSTETRIQRSTLTKLESMLRTGNRFVREFASAKARAAWDTAKEWVLRLCLPPGRDRRTHNLPTSSTEMAMLICDSDTNTGDRGPQDLILQVHGDRCPDGRPKYQTVSSLDPSAMPLRYPLLFPAGEDGFHPNIPLCGSIELGHSSPKDRNKEGEDEEEGDKKNGDGEHKHLWLLLGCSHSVKARAQTDIECLNTYDEGQVKGVKVVSLAFTNPLRSTCTNATSPHGTRRPFPAFVIERYSQAEADRLNYIQWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M855</accession>
    <name>A0A2X0M855_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C001g00688 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C001g00688</name>
        <name evidence="1" type="ORF">BQ5605_C001G00688</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY48742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M855"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY48742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="85" mass="9942" checksum="CF36DAA4237B4608" modified="2018-09-12" version="1">MACLDSSPGRINRTEVWISRDEMVDFWLYFASLDASRVMRSKMSLTNELRISIALFEIPVSGWTCFNTLLWTGQGRREIEFEFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M910</accession>
    <name>A0A2X0M910_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C004g02860 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C004g02860</name>
        <name evidence="2" type="ORF">BQ5605_C004G02860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY68170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M910"/>
    <dbReference type="STRING" id="796604.A0A2X0M910"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF75">
        <property type="entry name" value="ENDONUCLEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="636"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY68170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="708" mass="78643" checksum="1F96241EE960EC56" modified="2018-09-12" version="1">MGVPTFWKELEAAEERDTIMGIATTKFQSSPGVRGFRLGIDASLWLFHIRKVAAMDASEVGANADVRTFFFRIVELLSQGCVLIFVFDGPGKPNWKRGKRIGGGGPGFGNTKKKEDVLIRRLIDLFGMRRRIAPGEAEAELAAMAVRGEIDAVLTVIRNPPKTGKLAGPTQSKAEESAVEEPSLRKVKPSTTSTTTSKDARRIYSSLNILDTLELDQESLILVALLSGGDYHPQGVAFVGAKIACALARCGFGRSLLRCLELHRDGSAEQKRAFADWRAKVAEELRTDSRKLLTRKAPKLSQQLPGQTDFPNPEIVRHYTSPNVSSGLDPPVWDTPVNLKQLVLYCSENFEWSNADVRARFRSLVYKPLLMLEIRRRALYDDRNADRSVPEAPYRSEYEGPLFAEVRDLKNADSTQNVLSYRVRLDPLPFSTLINEALPAVDPYPRTEVSEGDFDTDGSVIKQRRAPKDYGDSITPFMHWVPVAYVEAHPDGREAVKQWEDKKANPSPRKKKEPVKTVPVVAATKGKGAPNTLMFKATKEGVAKAQVGSKGKEKKKEEEFDRFKTFLSPTTSPIKTKMRRTLFTVGDDPESEPFVIDDEEEPFVCDNEDDSDGDLPDPKTVGAVPRVPHKVIGTAEHLESPKKKIKVAPPPTLLVVDDDEGSEGSGGEELEVRELRNMPPSLSKGRALKREARDEERWGKCEVLEVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0M999</accession>
    <name>A0A2X0M999_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">BQ5605_C011g06275 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BQ5605_C011g06275</name>
        <name evidence="25" type="ORF">BQ5605_C011G06275</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000011">
        <property type="protein sequence ID" value="SGY11799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0M999"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="378"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="125"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="653"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="SGY11799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1253" mass="139053" checksum="CDD845A1A0194420" modified="2018-09-12" version="1">MELSNAKYDEDENMGEFLKSMIDKADQLDDLGQKFGDEAMIAYILQALPPSYEMLKQAIRLGENRSVDHVINRLTDEYTERKLSGKFDKLLKNAGALAVQSTQASRDPNCVCRGCKGKGHFAMDPECPKYDAKKNHGRARNRNKKKKQDSKESADSNELAEFVLTVKSLDESHSLQDNVANRVSQLNQGEIWILDTGASQHYVGDASLLSNRQSGNLKVQTASGQVVHCDTYGMVRLKLKSGASLSLANVYHLPGAPVNLISTRALFKSGAKCGWEDGKDVMTITYQGVILAKTLSSTGYALDFTRIVEDQAHVATRATVGAPLMEWHRRYGHVPVSSIMELVKSGAVEGLVLTDEKVHDCEPCISSKSRASKFSELATQVTDVLQRVFMDIGFVAEDQVDFQGRKAYLAIVDQYLTAKWTFPLKTKSAEEVTRVWIAFRQGVEKMTGRKIKRVRTDNGTEFTNKLIGADFQSQGILHETSAPYTPQQNGTVERFNGSLMAIVRAVLAASKLSWKYWSYALAYATFVANRILHAKLEGKTAYEVFYGKKPKVSHFRPFKSTVYAQVPKSKRSKLESTSVKGIFIGYDSEYNYRVLVDPDSDHKVIVTRDISVLEHKSEQVGVPEVTTLPVGPDEEKGPVDNDEIVVDELQDQVDGEQMPPARQNRPRWEYGDPAVKGRNPGRYEEIDANNEIPHRTCSQRRDAEQQVMYGSAMSVSLPPVPSNYEEAMASPEADKWIAAIKAELDAMARHQVLIDSDLPSGARALGSKWVFTRKENAQGEVTRYKARLVAQGFAQRPGIDYNETFAPVARPSTMLSLVGTAAAQGLFLEQFDFDSAFQNGTMTEMVYMKYPKGWDRPQTGQALRLVKSMYGTKQAPREWNAAVNSLMVERGYKRSDADSCLYVKRVDEKFIYITLYVDDGMVASNDQEFLDSEIEAFNKVYKLKRLGPVKLFLGLEFERTSDYIFVHQSKYIRDLVAMYGGGSVSKHPVKVPMEPRSDVEHSTDPFDDVALYQSAVGALQYAAHRARPDIVTSVRAAASKVSAPTQADWIAVKRIIRYLQGTVDWGLKFNHGGSTVFELYSDASWGDDMSTGKSIGAFVSILAGAAISWQIKQQSMVATSTTEAEILAASAAAKEAMWLRRLAADLELEQPKATLIWEDNQAVIAIALNPAHHGRTKHYNYCKTGAITADILTKPLARNLFELHREGMGMVGAGARVLCGGPAEAAGCLHEIASFWPSCFSLFSTTHSISHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MBJ4</accession>
    <name>A0A2X0MBJ4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C007g04574 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C007g04574</name>
        <name evidence="2" type="ORF">BQ5605_C007G04574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY61605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MBJ4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY61605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="90" mass="9335" checksum="A8A509CF7862E231" modified="2018-09-12" version="1">MALLDGGTSSSSLVQVGPTPNGQPPRRAIALRLSEETLAQLMALASRGSQPNKGTLQIDLGSNPGLTMRDVLAPSVPFTSPSLAPRSRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MBW3</accession>
    <name>A0A2X0MBW3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C008g04933 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C008g04933</name>
        <name evidence="3" type="ORF">BQ5605_C008G04933</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY78742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MBW3"/>
    <dbReference type="STRING" id="796604.A0A2X0MBW3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="2">
        <location>
            <begin position="271"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY78742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="774" mass="83166" checksum="8761F3E6BDF6E07B" modified="2018-09-12" version="1">MPSSSRPSVSLNIPRCATSAPARWLSLGAAAFLTLVLCASTASALPTNQRRAALAEPLFARTSAQLGPGEPLERLRQRRNAAAANLVLADRQRAARSNSKPIVVERIIPKRAVPNPKRASKGYAFAKRAPEPRATTNPKACDERAASEAQSSGFRRSLSSFAGRFFGNMVERRAPVAFRDFTKPRTIPNPKSPTFKTSATTTMKSATPRTTTASSTTTTKASTTTKSTTKSTTTTTTTTTTTTTTTVKATTVPPAATTTAAGAVWPIVDSMISGAYYPDWQGDTLPPANINYKMFDLIHFAFAVPYVISTDNYGVKFSQWNSETLLAELVKRGHANDTKVVISIGGWSDSGKFSNAVSTRTRRNNFAKNIAAMVTRTGADGVDIDWEYPGTEGASGNAISADDTANFLLFLQDLRRVLPTSRLSTCTTQQTFIDAHENPLADVSAFATVLDGILVMNYDVWGASPSPGPNAPLENACPNSNQPFANMNSAIQSWTLAGMPASKILMGVPGYGYVSASSKTTLINKRSIDDEFSEVAGRELLQTAGARRNIAEAPTRHMSVFHRSYLEGQEKAMRRRAKAKRAARGGDVFTQPSTGSEVVKVVTKNSETIIFCPGDHSGKPCEGVQGQNISTINWNPLNGTKNGTTVNGTSSGGVFAGNVGHTKLGKGDLTGLDGNQIAFWELINYGVLVKKDSAYVGTNGYTRAWDKCSSTPYLYDVSRKTVITYDDPQSLQLKGALARQKGIQGMLMWEMSEDTVDFQLTQALRLGMGLRATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MCE7</accession>
    <name>A0A2X0MCE7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BQ5605_C004g02889 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BQ5605_C004g02889</name>
        <name evidence="9" type="ORF">BQ5605_C004G02889</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY68443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MCE7"/>
    <dbReference type="STRING" id="796604.A0A2X0MCE7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF21">
        <property type="entry name" value="MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SGY68443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="561" mass="62418" checksum="FA3E5C13CF043FE6" modified="2018-09-12" version="1">MTSWGCGGGSRGVAIKTGGSEHVRCEIDQRQCKDRPVVMRYDVQRGSERGKRCKGVRSAPTRPTPARPEAAWFLLYYWWPPLGLVPTATMDTVHSVLPAFASLREYTSCSVSELLPPYVSPRKPFSALSALAKAEEIDSRRVRTSKVGWWSDVRRIKGSTWPRIWRAVTIITLWAALIAVLEFNYQQRLGLTNNVTPLLSVVVGLLLVFRNSSAFQRWDEGRKAFSTLISITRSLSRSVWINVGAAAPPKFERDGSQIASNDPDLTERDHNAKVKALRLMVAVVVATKHHLRGEYGTDYEDLSALLPSKFKEIVGTTGFGWGAAEGEGSQNQFLTVTVQKLMPEWWSIAQEIRRLASMPFLRPPPKSPQTPMSPHHHSHTLNEERTPLLHRSTSHVSTHSAVILNDSLAKPSIPLPLLITHQLGLYLAVCKKKGLLESIGPAGYNAMSASVSTLTDCFTTVERLAVIPIPPVYGIHLKQSTSLYLLTLPFTLVEIMGWKMVPFVTLCAFTLMGIEGIASEIEMPFGLDDSDLPLDLLCAELRNEIEHVISRLSAQHDDWVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MCQ1</accession>
    <name>A0A2X0MCQ1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C008g05203 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C008g05203</name>
        <name evidence="2" type="ORF">BQ5605_C008G05203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MCQ1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY79701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="205" mass="23078" checksum="B269648BD955B533" modified="2018-09-12" version="1">MLFLKVPSRLSVSRLSHLPPNSLSHILTMSFALAHNRPLEIMHLYFDDKQEVMATCLLATNETVELVSVVSISDRRVILRALAHELLWSVIRTVYFLEVLPVIWHHIIQTIRTVVRGPVNMNARQARDDFADAVADTSHISAQSDRAMSHFLATISSPLAHDVEARLLQPGRSLPCDARGDASHLPRSSNNACTRQRGPYRDQKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MCQ6</accession>
    <name>A0A2X0MCQ6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C013g07284 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C013g07284</name>
        <name evidence="3" type="ORF">BQ5605_C013G07284</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000013">
        <property type="protein sequence ID" value="SGY15198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MCQ6"/>
    <dbReference type="STRING" id="796604.A0A2X0MCQ6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16982">
        <property type="entry name" value="CID_Pcf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045154">
        <property type="entry name" value="PCF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054127">
        <property type="entry name" value="Pcf11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047415">
        <property type="entry name" value="Pcf11_CID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921:SF3">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX 2 PROTEIN PCF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21936">
        <property type="entry name" value="Pcf11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY15198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="619" mass="67855" checksum="FE633F6965AB0200" modified="2018-09-12" version="1">MPLIPANLRPHQSPPSFKLPALYLLDSISKNIGPPYLALFARFIKRGFVDAYHVSDPATRVKMEELLGTWRTGGADGGELFRGHDQGEHDSVQRVIEAALFGTFGRGGGMGANGRSVQESESFQSGMQQITPTASNGERSGILFDLRRLLQLRLDQAAQKPSDEVNQSQIDALRKLEYLVLNTQLTTDQVDRIRGQLAALAPKETSVEPRPHKRDTSSQPPQSLLAPSSLAQLQQLARSLSPPVLGTPPPPSAHQSTVIPTGNQSRDPTPSTLAVPPGLSAPSMGSSSSTTPTRGIDLSLLNSLQANGSLNSLLASVRATPPPPPSSTKTKVHLDTQPSLLTVDPLAEEYHHSLLSLSLPLTTSSLLKSSTSSQISFEFIYDRFRLQCQQCGLRFFDSIQGKNKLDEHLDWHFVNKRRIREAVSRTQGRSWLSLEEDWFVDSLDDDEQDSMRDFKKGGGAGIVRGGGGGTEQSRKDFKASQDAKLDLQLLRKSKVVAPSGGDERRCGICREKFKSEWSEEEEEWVYWNGVKVEGTIYHATCYAEAKAATNAARLRAEEAHQTSSREATPSDPVNAAKKRKMQEEGEGVKAEEESIKVEPGADNRSEEGESPMKKVKSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MDY6</accession>
    <name>A0A2X0MDY6_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C004g03127 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C004g03127</name>
        <name evidence="1" type="ORF">BQ5605_C004G03127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY70238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MDY6"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY70238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="174" mass="19428" checksum="102ED00E2ADBC7E1" modified="2018-09-12" version="1">MTRTSRRHTSSTCQNNRREAVPYSLNFLAAISRFVNTCCGTSAHPHDLKAFKHTDQSFSTATGPALSVYLISFYDLHARMAQSQEADSINDWIAEQADSIIIKEMKALPQLYRSVMGQIAFVCSRRNNAMQHRNRLMTLACGANDRLTTFLYDCGLTTSRWAALQAAASLTKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MEA5</accession>
    <name>A0A2X0MEA5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C005g03249 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C005g03249</name>
        <name evidence="10" type="ORF">BQ5605_C005G03249</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY73018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MEA5"/>
    <dbReference type="STRING" id="796604.A0A2X0MEA5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21157">
        <property type="entry name" value="PUA_G5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000018">
        <property type="entry name" value="Glutamate 5-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654">
        <property type="entry name" value="GLUTAMATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654:SF3">
        <property type="entry name" value="GLUTAMATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/glutamate/uridylate kinase" evidence="9">
        <location>
            <begin position="46"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="293"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="478"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="492"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="510"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY73018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="607" mass="64995" checksum="450F75AE665EDD01" modified="2018-09-12" version="1">MYLGLQVIRLRSGINSGRLVVSEVLIRSDAVASFSLAASVSPTLRGSSSILHPERPHFPQVSTLSAVVETCVKLRSLGHRVVIVSSGAIGMGLHRMRLPALGPGKKRAIGEKQALAAIGQGRLIALWDQLFGMLQQPIAQILITRNDIADRSRYLNATTTLSTLLQLGVIPIINENDTISVSEILHINKFGDNDTLSAVAAGMCGADYLFLLTDVDGLYEDNPRKVPGARRVKICRDIEVVRKMVSTATLGSSLGTGGMETKLIAAELANGAGCATVITLGSAPHRIVEIVQNHHQHHPSSPPKAPSSTTNLASSTPDLATTHPSEFSNSSRTHSHPDLASELPPPSSTDTDSLPAVEFALATDPLPYTLFTPRPRPLTSRRFWVLHGLTPRGTVYVDEGAYRAISRGERDGGGGGNGGRLLAAGVVRVEGIFAAGQAVRVCVIKGRKKKKKSTFVQEDIEMKKEGANSFARRELEALTNQSVQSRPVSPDHFAERGRTTESRREIFTPGSASPSQSRHASVSASRRGVSVNRSRGEEDGAGSSSGLGLEEGEEVVEFGRGLTNYNSAEIDRVKGLRSSDIEKILGYSEAEHVVESIVEVRNEGSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MEN1</accession>
    <name>A0A2X0MEN1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C135g13391 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C135g13391</name>
        <name evidence="3" type="ORF">BQ5605_C135G13391</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000055">
        <property type="protein sequence ID" value="SGY88968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MEN1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="713"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1292"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY88968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1536" mass="172914" checksum="B7B4549FDB0EA311" modified="2018-09-12" version="1">MIIDDGQTTITTVSRESTPRSPSWPPLSPETLAKSLREGAEWDRANAEAAARVQAENEAIINAQLDAQEPLVRHQFAEWGQEDGQLRFINIRGTGSRSNKKMKRSQTVADLSDPSDDPVDVKRVLNRVKGRAGKEVAGQGKRVTRSMSAAAAMQVEGAKAKAEKGKGVEEEKRWSDHEPEDDILPEFPLFEDNITAKSTWNVRRCMGIPEKRRDIYTYLSTFKASAILLQEHFIKPELWQCIKDEYEGKAFISKHCLTLIPADSPLIDAEILRTHSALDGRILVTSFRLRGDIRILEINNLYAPVDTKQRLTFFDKLHFHRTQSTHLRLLGGDLNDCPLPAIDRRNQGRHGHHWPILIGKLDSPYTDCIRFKHPLTPSFTRPNIVRKRPKSFSRLDYFLLQRTHQKRLVQASTIYDHPKDLSDHRPVSIVLVLSDERGDAAQPNNSLPTTSNQLHRINAATFKTAAFQGMLEGWLEGASGEEPVGELEVVLGNCEKEGRELARREHRERVERMAVLVGRVQDLEALPVMGDEETAEWTRTTEELRRAVNERARQLRIRAHVPEIATEERLSRPVHAKLAARSSDSKITALRLPNGELTHDIDVALDHTQAHFQRLYNLEPRDRDHVERLRDDFLAPIRAARTCDDPSSDPLFLRRLSEAHIELLQQPITEDEVVAAIATTHPGRSPGPSGVPYELYHTAPRAWAKALSRAFNAMTERGSLSPRQGQGLVRLLFKHHKIGADRAELSSYRPITLRECDYKLFTKVYVARLNHVLPDLLPPQQHGFVKGRRSADASFHLRLLIEELGARGTEFPDAALLSLDQSSAYDLVEHEWIFAIFDALGAPAAFQRVLRMLYSGDSTTARYIINGFLTPPVRLTCGLGQGDPASSSVWDVVFQPFLDALHRRGIALNLSLPTIHPYPQSRAITSLAFADDVVVAVAGSESLTLLDDLALDWRLATNGRLNTDKTVVLPIGCRWEAGDRPLVVKAEGESLEWIGLSFDPTGNTELANVNLVARLEAVLDSARDRGLTHHTRAFYVNRYAIPKILHILSADIPPLEVVKELDRILVDFVRGGKRRSCYGKDVVFTPRFKGGLGVMRMQDVVDSVAARVWDVLLGGSDAIWQGLARAAIVRAHPAPDFDLATDAWPCDYTPIRTDLHPRWQAVLKVPSTHNAQVKPRTLTLANLLALPIKLHTLHYLPGAPAVSRSPYDADYAAFANYAKVADLFRRELYPGGGFHLWTPPTDVVVSNSEYDQRGRPQREHIVAWYRHAINRLRFTPIAQPVAAVRINGPPRVRPRSEVRPTTPLESILPHPIDPPQRLPRPALPDQSTQYNLLSMDRPYTIRRVRRVLNAKAFTDTIGFRDSLQPDDLKGFWKGVNSKALTAREREVWFKLVRNFTPTRSLQFHQKHDDSPACLVCGAPKDDREHYFFDCVDSGNVWIAARSVLCDALGLDTIDNTHYTAVQRMFGLPKLKASLRDQEGAGRTIEIFTGLVLEMISSGRWGMQKWGTRMEGVGRRRIILEERLKLRAGGAWGRRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MG77</accession>
    <name>A0A2X0MG77_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C008g05070 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C008g05070</name>
        <name evidence="1" type="ORF">BQ5605_C008G05070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000048">
        <property type="protein sequence ID" value="SGY79195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MG77"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGY79195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="72" mass="8603" checksum="2780B49B4F02427C" modified="2018-09-12" version="1">MRKWKIWRKGWGRAHNDEKGLKKGCDSVYRTQDRQLCSFFCAIRRERKGRGMKRNWRGGTCALEIYALSGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MGK4</accession>
    <name>A0A2X0MGK4_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribose-5-phosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-ribose-5-phosphate ketol-isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphoriboisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C034g11321</name>
        <name evidence="10" type="ORF">BQ5605_C034G11321</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14657"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="EC" id="5.3.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose 5-phosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="4"/>
    <dbReference type="EMBL" id="FQNC01000065">
        <property type="protein sequence ID" value="SGZ00014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MGK4"/>
    <dbReference type="STRING" id="796604.A0A2X0MGK4"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006014">
        <property type="term" value="P:D-ribose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000014">
        <property type="entry name" value="Ribose 5-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000053">
        <property type="entry name" value="Ribose-5-phosphate isomerase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00170">
        <property type="entry name" value="Rib_5P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020672">
        <property type="entry name" value="Ribose5P_isomerase_typA_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001924">
        <property type="entry name" value="PRK00702.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934:SF0">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75445">
        <property type="entry name" value="D-ribose-5-phosphate isomerase (RpiA), lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGZ00014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="312" mass="33751" checksum="5F89E4B75E1B5DE6" modified="2018-09-12" version="1">MAPLPENPKASSSQPNSRRPSGVSAMGRPDPLSSIIHASASRIGPGAHPTGHPDNLNVLSPEETAKRLAAYAAVDEHVKPQHKVLGIGSGSTVPYVVERLCQEPHCADNLDRWFVPTGFQSKELIVKAGLNLGDVDQFPEIDVTIDGADEVDDELNAIKGGGACHLREKVLAEAAAHFIIVADSRKDSKVLGTNWKQGVPIEVAPFAWAKVFQNLQKMGCEKPTLRMGKMKAGPVVTDNGNFVIDAVFSEAYMRDPTELLHRIKMLTGVLEVGIFANMALAAYFGNPDGTVTIRWQDGRRHVKEAPKNLVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MHH8</accession>
    <name>A0A2X0MHH8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BQ5605_C032g11095 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BQ5605_C032g11095</name>
        <name evidence="1" type="ORF">BQ5605_C032G11095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000067">
        <property type="protein sequence ID" value="SGZ04882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MHH8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SGZ04882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="424" mass="47558" checksum="1B3A6E260AE2DF7C" modified="2018-09-12" version="1">MTPWACSSARCWAPRGSTLLFVPLRSTESAPRRVMTTIQPILALRHVYEPAVQLRVRRARIALKPLKPHVSIRDDLGPQTAVCTHCKAQHWELGATVFRVFGRLYHRLGALIPAVNQCPAFAQTWLINPAEATDTRLEPDGADSHMQRSTLTKLESMLRTGNRFMREFASAKARAARKWRCLSAIPTPTREIVDVKTLFSRCTVIDVPRVGPSTRSLARSIRLRCLRYPLLFPAGEDGFHPNIPLCGSTMVSNCARYLPVSVWMTKTNRRTKTATMRMKTARKGTKRMVMANDEGQVKGSRWRVSRSQFFAHYLPKATSTSQSRIAPNVPSWTIPGCDGVRCQTWKASAAHHDDVRPRLTGNQGCTGADKACNRPDLIARVFEAKSGNKRHAGCFGNECKMNGFCFFATVRLSCYFLNFILPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MJM4</accession>
    <name>A0A2X0MJM4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C037g11611 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C037g11611</name>
        <name evidence="3" type="ORF">BQ5605_C037G11611</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000062">
        <property type="protein sequence ID" value="SGY93809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MJM4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019412">
        <property type="entry name" value="IML2/TPR_39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10300">
        <property type="entry name" value="Iml2-TPR_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY93809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="836" mass="90281" checksum="8BB338DF8E04A6B3" modified="2018-09-12" version="1">MGNVSDSPKGAGAEKVSNPVVEVTPSSSSSTAGDDIPSSSPSSSSSSSASTQPSTLIGIGIGIGIGIGVAPPAASESATPLNPTELFLDATRGFDSLLNNQLDEGKRIFERYPDSAAHSVGHGISVFLQAALGQEDQALYGALNALMKAETLSTKEVNAKRSVGAGVYAPGLEYKALVSDAVMSQALCHVLTESYVEFMKAIYKLNRAYKGFKSLYTVGRVSEAVSESDSLESIFTKLNSNYLAKTEGAQPSSTPGRLTPNGASTPTSATTPTSSTSSSPSLSFFGSWGRKRADPNAAAIVDVPSNLLRHSSSAVTLPSQISKLGKTDEKPNIKITTSTPGSNLASRSASFEILKGQRIEQGVDGSHPAPLWKDDPITSLVIGGAAFGYGLFGLIFSLLPPKLRKLISWFGFGNSNRSAALKLLTVAASTGNDTHAAFASLTLLTFYCVVLLMSGWQSDEEYLLSQCEIVLERVIERFPEGTLWILQRAKIARMRHDVHTAIQVLETSLSQGSSFREADSLLQFELGWCLLSDGRFVATADSFERMCELNNWSHSTYVAIAAGALVDDRRLTGGSEEKDQRIEAAFKRLEDLLVGGKSKRMMGEPPTTEMFLNRRLNSYKAKHARWIEEGRLPKTSSYWEAVRMTSAMELGFVWATIGGRSPPAAIRAQIDYLASLTPSPAFGPHAQHPASPSPLRRCSTSDDLDTLDEIATRSLLLGALYRSLDDGPSLHIAREFLQSITKHKEGIKEEKWVPSFALFELAVVECKECELETRRLEKEGVEGKVVVGRWKDGLGKAEKLIENLFASGEYDLKSRLESRTTQLRDEIAAKKKKLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MKA9</accession>
    <name>A0A2X0MKA9_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BQ5605_C021g09330 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BQ5605_C021g09330</name>
        <name evidence="12" type="ORF">BQ5605_C021G09330</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000083">
        <property type="protein sequence ID" value="SGZ21074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MKA9"/>
    <dbReference type="STRING" id="796604.A0A2X0MKA9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000710">
        <property type="entry name" value="Zinc finger protein 768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="175"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="203"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="234"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="442"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="347"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="480"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="366"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="382"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="405"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SGZ21074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="633" mass="71384" checksum="812066C3ABD06954" modified="2018-09-12" version="1">MLAVGSAMSVLHSFTPAVSSSQQPSSSSHHSSPSLLSHPHQATISSRTAIITTDTEIQHHAPVASTSTSYLQADRITTSTLASTSTATPSKPLLIVGGKVVASPTSFGTSGGRLKKFICPECGQGYTRPTRLQEHQRVHSGERPFRCAECPSTFTRDSHLRAHARIHVSEQEKRYDCNECHKKFWTHQHLKKHIQSIHKGKTYDCSQCDQSFRKHHLLRTHIAEVHSPPGTFPFICDAEGCDKSFKQKTHLTAHRKTHDRESFFLLVRSPCSHGNELMIETTRLASRYLCIHRDCSSLSLSQRQHTTWSALQKHTKTVHPPRCHYPECDNKTFTTNRGLRNHIASIHEGSTSAEDTDAPHKTTTSRSRRKRKRRSGRKRGSDEEELEAQETETDANDGNVTSEWEQSEWDREDDEREERMLLDFAAGGKKKRRIVLAPEAVWKCTHGACKRPFKSSDALGRHVKALHSIERLVPIVEVPVHRPRSQSRGTSMRPAPPKEDDLDSAQDSTDLEALPPLPPLPKRKRAPKSPTAMSLIESITGYGYAPADEDERSQAASKRQFPCPWPDIAKLDHRIIVDDILCSPNGHIVQTGSCEYWFSRVYDVERHLRGAHQVVVEREELEQWFDAESEEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MP72</accession>
    <name>A0A2X0MP72_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C024g09774 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C024g09774</name>
        <name evidence="3" type="ORF">BQ5605_C024G09774</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000086">
        <property type="protein sequence ID" value="SGZ25808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MP72"/>
    <dbReference type="STRING" id="796604.A0A2X0MP72"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053828">
        <property type="entry name" value="Nucleosidase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF22">
        <property type="entry name" value="ADL392WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21953">
        <property type="entry name" value="NadN_nucleosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative 5'-nucleotidase C-terminal" evidence="2">
        <location>
            <begin position="454"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ25808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="710" mass="79791" checksum="556948AD45ED4194" modified="2018-09-12" version="1">MWLGVIWIGVLRRKEGGDEGQEGRSQAPRTRSRARAGIASESIVTDTARTDRLSERGPGAPTGYTVLNQSPHGSLWLGTTTLAATPQIAFQAFPDRPASMPLQQPGSGPDPTDRPYRALPWGDVNIISTTDTHGWLLGHQNREPNYSGDWGDLYSFTQRLRHQARARGVDLLLVDSGDRVDGNGLVDAEPIEHAKGYTAMQYFQNMPYDVITTGNHELYAIPSLASNVDIRITDESSEKLVPAHAAGIRVQAPREMIKEPWFLEAVREEPSFFLLVGHMSIRYELDSQWSLIVRAIRAVHSRTPILIFGGHHHIRDCVMVSRNEHVFGYENRLLIRSARCSSLQEDERSMSIAAGRYMETIGWMSVSGIDANNTLTFERRFLDQNRATVSIRCDLYRALRLLLTRPRALLRLSQYEFHAGEKFDTAMGQAITKNLSEVAKGFNLTHRYGIAPQSYYLSRHPHNSQQSILNLLTTRVLPLLVTRPDRPNPSWVVLNSGSVRFDVFKGPFTRNDQWIILPFSESGNPNSFLFVPGVKRSVAQQLLAYLNVVGEHKLTTSSASVSVRSTEDNYEEDRWVQERESLHLEHLHRRALLEASNLSTSILPSDDDEASSPSIGYVTQDACGGLGDDTLHRPVPSVWQPIFVATEFPPSSAATDRIDVVFFDFIQPDILGALNTLQNEREYASSDVKLFVEDLTANTLMQEYARREWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MPI7</accession>
    <name>A0A2X0MPI7_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ASTRA-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BQ5605_C001g00042</name>
        <name evidence="7" type="ORF">BQ5605_C001G00042</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat ASA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000043">
        <property type="protein sequence ID" value="SGY43649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MPI7"/>
    <dbReference type="STRING" id="796604.A0A2X0MPI7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="24"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="355"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SGY43649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="418" mass="46002" checksum="2EFD43B770950D5E" modified="2018-09-12" version="1">MSSLIASTSKAIDYSVPPSPVYILRGHTAQISCVNFSHDGTALFSGDVEGWVITWNLSSFRPRLVWKPHEAGILTIEEFDDGLLTHGRDNKIHHFQLPKSLRSITRSAASAVPSVKDPTPLHPDWSMDVNAMAYCQMSLLRIASEEADGGKGKGKERALVAVPALTKDEQVDIFHLPTLSRVHRSIGEGCFIGSKTGTVMAIELFTNPTSPSQLHLLAAYEDGRIALFSYTSSPSSAVSPPTNYRSESEGWGLKWISKGHREAVMSMALSPDKKEAWSIGADHYLCRYRLWEEEEDKRLDRFEMTGPGKSAVGVRDDGRIIAVSGWDGEVQICSTKSGKPLAVLTYHRTSLQTLAFAPTRQSAERDAESDNESDDEEDRGNGQQRAWLATGGKDERISLWDIYPPHSLPAMTSSLGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQ78</accession>
    <name>A0A2X0MQ78_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="28">BQ5605_C044g12134 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="28" type="primary">BQ5605_C044g12134</name>
        <name evidence="28" type="ORF">BQ5605_C044G12134</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="FQNC01000114">
        <property type="protein sequence ID" value="SGZ31304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0229">DNA integration</keyword>
    <keyword evidence="20" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="18" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="21" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="17" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="18" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="19" id="KW-0917">Virion maturation</keyword>
    <keyword evidence="24" id="KW-0862">Zinc</keyword>
    <keyword evidence="24" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="26">
        <location>
            <begin position="295"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="27">
        <location>
            <begin position="544"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="801"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="857"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="915"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="801"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="857"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="SGZ31304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1497" mass="163831" checksum="4AE33C7D0F00E619" modified="2018-09-12" version="1">MDSSPASPLAPRDPSSPESSIGEQIATLQAQLAALQASQPAAAAAATPAVTAVPGNAATASKVVFPKHARLDGPKSFTNWLRQLRLALPNQVRGYVLDGVMPLTWTADQLAARDDAAREIIVGSIDSADVSATLDAIPSNDLSAPRIFAALKARFAPDDATRTLELFARLWDFRKMPASVEAYDTWLREYMSIAQEIRDAKTSLNDVLATHVLAMVPSCLDSFRLTFTDEQRHRRDLPELTTLTDRIRIQLRSAGLSTSHSAMLATSSPCPACRAPGHRLRDCTSRAKHPPTGPCRRCHKKGHWALDCKNRGEQARRSDDTQDDTSSSAALQPNVGYFASCLFARRQLPTDAFVVDSGATTHMVADRSLFTTYRQTAHTKIGGIAGGITAIGMGDVAFVAKTGHPITLRGVLHTPGLHVNFLSVARLCDTDRVCLAFTSDGIDIAKDGQTIAHGTRVNDGLYLLDADHTKCQQLAFLSRSESTVPLITLHRCLGHLAPSSIQKMIAAGLLDGFGAGYSDKDVEEFVCNACLGSKGHCLPFPDSESHSPERLGLVHSDVLSFPTPSLTGKRYLVTFLDDHSRKLWAYAIDHKSDVFPTFQTWLAEVELETDARLRILRTDNGGEYRSNAFTEFCQSRGIRRQYSIPYTPQQNGRAERVNLSIVEGVLALLADSHLPATFWDEAAAYFVYCKNRCSHSALAKQTPQFVWNGQRTTTTVLHPFGCAAWLTVAPDLRSKLDPKAARVIFTGYDLASKAFRFFDHSTNKVVLGRNATFLDDDFPGLPVNMPVDADDTERQFVIPADAPAPDTADTHAPAATPAPAVKTRTPLVRSAHMDVSSPLDDSAMSAVDVAPGYTGGSLLNSTDTSPSSSPSLAPISSPATSSAGGPSIEDSDDPLDLLHSDTAVRLRLMDVHRSDDDTLVTPTPAVGPGQPSDDDSPDEIDFLSRHHRAFIATDDDNPTLEAIEPVKSITSDPQTWREAMSSDEHDLWAQAASDEFTAMRDDFKVFTIEPRSSVPPGATIVTSKFVWKTKRNAQGDITGRKARLVAQGNRQRDGIDFSETFAPVARFSSIRCLLALAAANGYHVHQADIDKAYLHGELDHDIWMTTPRGFDFPSDQVLRLRRSIYGLEQAGRIWNRHIDTSLRSLGYTATGTDHCIYSRIDDQQQPHYIALYVDDLLIVSPALDEIERVISGLEQRYGVKRLGPAEYILGIQIRRLEDGSIALSQERYIMDVLARFHFDTTTRGATVPMTPGLSLTAVPGQGTERIRSWYLQAIGSLLYISLGTRPDIAFAVSYLSRFANNPGRRHWVAVKHVLRYLRATYRDELLYACGPTKITGVVGYSDANWGACVDTSISTMGFVFYLAGSAVSWSSKRQTRVADSTTDAEYLALSHAGKEAIYLTQLLSELHVRPVDAAHIFTDNEAAAAVAHDPVHTSGTRHIRLREHFVRDMVHQGDISLSHVGTANMVADIFTKALGPKIFGVHCYALGLRTRHPRLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2024-07-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQH1</accession>
    <name>A0A2X0MQH1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C026g10176 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C026g10176</name>
        <name evidence="2" type="ORF">BQ5605_C026G10176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000088">
        <property type="protein sequence ID" value="SGZ27734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MQH1"/>
    <dbReference type="STRING" id="796604.A0A2X0MQH1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052988">
        <property type="entry name" value="Oryzine_lactonohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G08990)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064:SF2">
        <property type="entry name" value="SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="1">
        <location>
            <begin position="206"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ27734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="418" mass="44959" checksum="DE97D702D01A8F5B" modified="2018-09-12" version="1">MSYAAALDLVRPSSQLGRDANVSHHAASDGPFIAFHSDFASIVGANPTLDLIASTEKSQGGNGVSLFHEAGVWAPQKKGSDQGDVYITSNIIGNDRDGLEIKVCRLRFSTSSESAAKVAPSKSDSSVLVVPGIEYEDLQHLADEVVMANGATAYGFNILWCSQGQHKKFTAPLRNKLESSKDPKDDRVAGSLILSEPQADGTFKNRTLLNHFRGREFNALNDVAVHPQSGCIFFTDPDYGLEQGFKGPSQLPNGVWRYCPKTGALGMVADGLCKPNGIVCSPDGKTCYVTDTDYIHGDGTMVSTRMGAIYAYDIHHYDKIPQLHNKRLFALVDCGAPDGIKVDELGNIYTGTFEGVDVYHPDGYTLGKIVIPKDDEGNQRGCANLVFGPKGKLVILSETTVWIASIAQSGELKGLEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MQV5</accession>
    <name>A0A2X0MQV5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">BQ5605_C027g10317 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BQ5605_C027g10317</name>
        <name evidence="16" type="ORF">BQ5605_C027G10317</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000089">
        <property type="protein sequence ID" value="SGZ28341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0MQV5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15492">
        <property type="entry name" value="PHD_BRPF_JADE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000008">
        <property type="entry name" value="Bromodomain containing 1, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF107">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7 9" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="208"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="15">
        <location>
            <begin position="262"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="12">
        <location>
            <begin position="578"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="PWWP" evidence="14">
        <location>
            <begin position="1213"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="63"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="820"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="940"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="978"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1335"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="827"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="848"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="889"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="940"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="953"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1010"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1063"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1118"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1345"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1355"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1379"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1393"/>
            <end position="1407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SGZ28341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1416" mass="155590" checksum="50A77D2438320634" modified="2018-09-12" version="1">MGAHSNELPAVPEVHFSIVDSEALLPPHVDNKLLEDFGFNDGKPWTLIPSGTIPVAAHPSLEPVASTSGSATEAVASTSTAPATTTTNLDGATASNGLTFEPTHDSRYLRWLQPMESELAHQVEYDMDEQGQPSSRRSSWNDPLKGSLLACVIIDQVWLDGINASRKVEGAGPVSYEIFEIIVDKLEKEWFDLMKSIPKKPNPLLDTDSKCAICDDGECENSNAIVFCDGCNLAVHQDCYGVPYIPEGQWLCRKCTVSPDKPVRCVLCPNSYGAFKQTTTAHWAHLLCAIWIPDTGVSNTVYMEPIDGIENISKSRWKLDVAPSLSSHFAQICSLCRQRVGACIQCANRNCFTAFHVTCARDHGLELKMKQQTGTGELKAYCEKHSGGFTAGSVTPLGTCRDRPGRASLGAHAPSLSTSLQVVLANPKATSMSTKTQRAYKKSYTSGPPLVPSYILDRVNTYVSRIKIANKRQFMNQLCRYWSLKRESRRGAPLLKRLHLEPWTASASTRQQSDVERAKKLELMRLLREDLENVRMLTERVRKRERKKLERAQLLSRFVEQHVFAREVVMGDFIRRVSELDKHRFFAKPVSRRDAPDYYDIVKNPMDFSQMTDKLARREYPSAESLLVDFHLIFDNAFLYNKKETTVHRAASKLLEVSKSLVEDLKRLDDPMSDENILGRYLDLVLTDEVVDALFEFDPAKEEEGKGVADIVMQLLPTEADPAVQETRKDVMGEGATTEEVDTTTATQAVDDAIISTTTSAAAQSIVPTPATKTTLNDDHSAVAVEAEAEALAQVDSLPNPATKGPSTREDVVIEETAALPYPAPHSTEPTPSKSNSPKSSAKDETISKTATKSTITEPTNSEAVVEETREVAGPSAIVAMDVNPPEPAAEKPTSDRPIVEAASTPTLTVAVTREIGKARSTTPLPLFSEDSTMSELSSVLSSAVSEDSPSVEFKDAESDFEREVEDVDDMRSFKMFDSGWVLPEGSSRKAKNAIVEKGKGGQNTVSDNVEEKGKGKEKEKENTNDKRPVKGKGKAKEVETKAQEQSDPDAPPKKKRGRPRKIPIEEVQEPKVEPAPQPATATAPVQPPKSTGLESTSLDTPKKALGPPQAPPTLAEPTDDAAAEGGDDQAKESTTTGATAKKARPPAKIHGTLSIASTVRRVEVEMASKGLPAVPNPAAVKKEDAVRIEAFETNLARVERSSLVTADTQLKEGDLVWARSPGFPFFPAEVLDYPFTTPETREQMRSHRPKNAEADELVPILFFDPYRTSRWAKRDDLRLLGMNDEFDAMLATYDASLRLIFRRKMSNAHPTAAKLAEEIGEALRWARAIKSGSAEARKMARVGKSKEELRNGEGEEDAAEDEDTVGLTDPETKRRTTRSTSMSASTAGRKRTLIERDEADHEESSRRPATKKTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MRF7</accession>
    <name>A0A2X0MRF7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BQ5605_C018g08614 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BQ5605_C018g08614</name>
        <name evidence="10" type="ORF">BQ5605_C018G08614</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000020">
        <property type="protein sequence ID" value="SGY25429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MRF7"/>
    <dbReference type="STRING" id="796604.A0A2X0MRF7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13994">
        <property type="entry name" value="STKc_HAL4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584:SF369">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="395"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="148"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="223"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="148"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="223"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SGY25429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="599" mass="64116" checksum="21E7B2811F0E063F" modified="2018-09-12" version="1">MSLTSDSSYPNSSVHTPGTSTPSSEFDQQVDPLPTFAQLDLSLSRDQGSVRSTGYGAGSEAHTLSEVAHSNHNVLASRILSRTSVGEGAGGALSPENLPKAPTELPKVPVDHLSAHHFAMGPTGSAVASTVTLPSSVTATAAANFASTGTSGATTKSVSSTTRTVNSVPSTTSNATTATTTTTTTADQERTLMPPPATTTAPKPQAPVVQQKKSVFGKLFSSSNASNASLNSGSGSNGERIERGDSNAGSGTEGTGNGGANLARRSSKKEREQEKKEAKEREREHKEEQARLARRPSTGPTHQDLGHGTSPSGKDRSASTSRPRAGSHGAKEKEGGMGQALNDFMRNKVQRKSSQTSRKSDDGRSDHDGTSTRGDGETRSRAGSQAGSLSQKYGVCEKMVIGKGATAVVKLAHKWDRTTERLYAVKEFRKRRKNETEKEYVKKLTSEFCISSTLHHHNIVETVDLVQDEQNHWCEVMEYCPGGDLYAAIKKGDMSPQAINSYFKQILAGVAYLHSMGVAHRDIKPENLLLDAKGHVKITDFGVSDVFRMCWEKTTHLSKGLCGSEPYIAPEQFEHKGEFFGSHKWADLAIIVLTLEQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MT44</accession>
    <name>A0A2X0MT44_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C044g12135 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">BQ5605_C044g12141 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C044g12141</name>
        <name evidence="2" type="synonym">BQ5605_C044g12135</name>
        <name evidence="2" type="ORF">BQ5605_C044G12135</name>
        <name evidence="3" type="ORF">BQ5605_C044G12141</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000114">
        <property type="protein sequence ID" value="SGZ31305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FQNC01000114">
        <property type="protein sequence ID" value="SGZ31314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MT44"/>
    <dbReference type="STRING" id="796604.A0A2X0MT44"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ31305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ31314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="88" mass="9176" checksum="780C9ACFA2A9FB8E" modified="2018-09-12" version="1">MRLARSARLSPECEESTLRSVQDLGARSEPGASRTDLCARSEPGASARDLGARSEPGASGRDLGARSEPGEMARDLGARNEPGLLGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MT65</accession>
    <name>A0A2X0MT65_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C042g12022 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C042g12022</name>
        <name evidence="2" type="ORF">BQ5605_C042G12022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000116">
        <property type="protein sequence ID" value="SGZ31861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MT65"/>
    <dbReference type="STRING" id="796604.A0A2X0MT65"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="506"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ31861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="627" mass="66225" checksum="178BAC01C9C698E4" modified="2018-09-12" version="1">MRPTNMHIEMPARLSLAMAIDHATRTSSASTPSSSHSSSGSSASSSSSFASRDATSHPSINDDDTLLASAAAPAAPSLAWTCLAPSHGLRASPSTPMHDHTPPTTPLMTHPPGTSLALFGAGAGRRPSLLRRDSSVSSAASSVGDEDDTVEWTSEEQNKIKSVLEEYIESVEHAPFSSTGPPPSNLTSLVARAVMRANKLELQASTLSQAQANGTVAPKDESRPQKWRHGVRSTRRKVLAMVKEKQHEAIESTPRQDPDDTPRRKPLARQGSMDFLPEARNVAAVARLGSKLRRAEQAGPPLSASATNSYTSRPRAFRTASLSSIAGSPTQPPKAPMRPRPPGSPIKAPRMQRIGSDSTGLHHAEFAHLPSPGTSTSGMLWSEPSSSSSNSIFDLSFGAYASPVVTPKRGSELGSAFMSPAAGAAYPSPVSQKRAKHHHLALQDAPSLSLASPFETSFPTGVQNLAPAFGSAPPSAPRIVRPGPSPIKRRTGGRLGMSQSWADHLSAPPTSSSSPDDPTTASAFGFGAALDAQRLHPSSCLNSLDAPAHSRSPSPFDMNGTPSPLSSTFDLNDLSLEALDESKHGKTNNFIASNRTSYLEPSNCSQSLNEKLRDWDGRTNHAPQVHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MU62</accession>
    <name>A0A2X0MU62_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C007g04449 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C007g04449</name>
        <name evidence="2" type="ORF">BQ5605_C007G04449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY60566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MU62"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015887850" evidence="1">
        <location>
            <begin position="28"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY60566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="150" mass="16230" checksum="98A8483F7E31F2A3" modified="2018-09-12" version="1">MCRSSNMARLGMLILALITTVAPIAIALTHVENACAKEAVLHNDLSDGAKCKSITDLGCVCSESTGDAFLRSLGDYVKDGELPATKFPYPVESNRSDRNPCWQGRGRCREQYFANIQAYACAYCLFKDLVPPQSCGKASVSTVPTESDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MUM9</accession>
    <name>A0A2X0MUM9_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BQ5605_C007g04609</name>
        <name evidence="6" type="synonym">RPS0</name>
        <name evidence="8" type="ORF">BQ5605_C007G04609</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S). Interacts with RPS21.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY61841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MUM9"/>
    <dbReference type="STRING" id="796604.A0A2X0MUM9"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000012">
        <property type="entry name" value="40S ribosomal protein SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03015">
        <property type="entry name" value="Ribosomal_S2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027498">
        <property type="entry name" value="Ribosomal_uS2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005707">
        <property type="entry name" value="Ribosomal_uS2_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01012">
        <property type="entry name" value="uS2_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11489">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SGY61841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="346" mass="37773" checksum="7A31E3189C8BD275" modified="2018-09-12" version="1">MAPASRLPAALQATEEDISLLLTAQAHIGAKSVEKKMVPYVFKRRADGINIINLGKTWEKLVFAARIIAAIENPNDICVISARPYGHRAVLKFAANTGAQAIAGRFTPDIDSLFACSTNYITRSFKEPCLIIVTDPRVDHQAIREASYVNIPVIALCDTDSPLSFVDVAIPANNKSKNSIGLIWWMLAREVLRLRGTISRAPDAWPVMVDLFLYRDPEEVERDQEATKAEALEATETAAPAEAEWGVEGVSSGVAAAANLPSTDAGSYSMRYHVPFSVPPALLPRCELTCVGTQTIGPQQIIGVPTPRPTGPPSPLLLLPPLPMPPLLGGRRLRRGRRWQTRRKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MV64</accession>
    <name>A0A2X0MV64_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C007g04819 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C007g04819</name>
        <name evidence="3" type="ORF">BQ5605_C007G04819</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000045">
        <property type="protein sequence ID" value="SGY63700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MV64"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="424"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1021"/>
            <end position="1047"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY63700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1230" mass="137900" checksum="91A8D947BD036F62" modified="2018-09-12" version="1">MMNVFYQKKNRDFYGLLHFTAPGPKTLRILAGDLNDCPDVSVDRVAITDRAWTPVSHWQTLLSKIAFNPLDTIRQLHPITPAFTRPHYLGRGDKREICSWSRIDYILVQRSWANRLLSASTLFDAPCSDHRPVVATFALPTSNAADAEPPPALPTTSEFISRLNPTVFNDQDFVDSIPGVVDEVYRRLEGTAPLGDVYDAALRAVAAAGHARYRSTRADMRRLRAENQSVMEALEARGEHMNEAERDAYALAKSQLDQLAVKEAQWLRIRAHVPSVDSREGQSASIRMRLNRRSRQTSIVSLEDVDGTETVDMQEALGIASRHAQSLFTPDPARGDPTNPRRSLLGPIRAAKCYDDDRSDPTFGRRLPRQARVALDEPFTLLEVEAALKKTDSGRSPGPSGIPYELFKALPTYFAPKLLDLFNSIWEGGKMTASLAEGLVRLLPKNKPGANLKSLGAYRPITLRETTYKVLSKVLVARLNGVLGELLPPAQHGFMPSRRSADAGSHLTLLLEKLRSLGTDVFPEGALLSLDQQSAYDRVDHAWIFDVFEAFGFGERFISLLRALYDPETLGVRYLVNGFPTDLVRLLCGLGQGDPLSCPVWNITFQPFLDALVRRGIALDLQKVWPGGPRAQLTHLAFADDAVVVVESPAALSKLETLSQTWYEATNGKTNTDKTLVLPLGPNWLRDETAQALPTVQEGESFKWCGYAFFRHGDSKLFWTHVLDRIKAKARAARDRTLSPSGRVFYANAHITSTVLHVLSFDIPPQWFIQAAETALTDFVWGGPRRNTVAREFVFQAREDGGLGLISIGDIVHSVALRFWDAVAGSDEAIWAPLARESWRSLVAATRDFSPWGFFSSTARVEKLYRDSARWGAVVAAARVTLPTIKSELLTLPELLSLPPRLPSLYAEGAKHAYDDADAVAKFAQIADLYWRDEGKGWALVGHRRGFWQHSKEPALRHEHVWARVGQKLKAKALLPKTAVRPARIPLKEDPHPRCFNFFGLTRPFTIRKLRRLVNTVRFPGKDGQDRALPGGQPQEPRVKRFPEGTSQSGRQRFWSWLHDRFASAAEQDTHWRLMYDVTPTRKKQHVQGHASSPSCLFCGNDAAVIETVSHYFFGCAYSASYWSGVLRILFDKLGIEDTDVDPSTFTQEQLTMGLPLLRGRGRTTSKWMWVRLACAIGFQRLHLLRWHVHQRFEKDRVVAPPSIPSALRAFNRDYLSRAGFVPGARDWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MXP5</accession>
    <name>A0A2X0MXP5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BQ5605_C005g03404 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BQ5605_C005g03404</name>
        <name evidence="6" type="ORF">BQ5605_C005G03404</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY75152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MXP5"/>
    <dbReference type="STRING" id="796604.A0A2X0MXP5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013882">
        <property type="entry name" value="Ctp1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08573">
        <property type="entry name" value="SAE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA endonuclease activator Ctp1 C-terminal" evidence="5">
        <location>
            <begin position="933"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="192"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="392"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="457"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="907"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1002"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1046"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="407"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="423"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="483"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="529"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="557"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="572"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="612"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="645"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="688"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="710"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="768"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="820"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="847"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="873"/>
            <end position="883"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SGY75152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1070" mass="117474" checksum="DDC96013B79EAB67" modified="2018-09-12" version="1">MSQRSELLDVPSFQASADHRFRDSRVARLTYVLAAIGQTSIDSLEDFIFLHGAARLVPLSADEPRSLETQQLPPTTPAEEVSEIRKRALIELKDELKRKDKELEYTHRLYEQEREEKLGLRRDLRWFLDLQRPEDRPPSHTDPGRSGLKAKALAQLQTQLDEANAVIDKFHQQQQTLQAEIERLRPALEQAQQRNVAAERPAKGLTPPAETLLSAAQPSSATVTRSPAPRAGADDATTSAKSKTSSSTAPASTTASPLRSARLQEALYETLHKRYLSNKKRADDITNWAMTKLQAFIAENSTYLAQLPPTPPLPPTSELPELPPLKVVLGEPSEDAVGRFSVALSELKRWDDDAQAVVGTLVRWKSIIKDTARRVAALKEAKDASKAVVAVKKRRKVKKSPADLNPSASTSSSTKRSSSPLKAGRKAGSPRRSRLVSEALNGPASGLVLRADGVFAKDASSSAPPASPPKRVLSPSPSAQGPRKIDAPHEETQIPDSPMKSNKRKGNLGLEASTSAKSKRARRSSFKTNQSPLRSGVQNGQLESSPQRGSPSPLQRQQDRILSQKEQRKSPEAASIRAPSIPASSWGPEPDTEPDDFFPPAAQHDTVDEVTRSPSARVSSQDTRSQPPTQPAILKPVGLSPFVPSVARSQASATRASSRGTTVSHSPLSQNLWKINALPESEKKASVNDDEDDDHEDDDDVSKRPPSPSPSVAKPRVSSSPDDTRLIRTPLIRSPANRPKVTEDEQPLMGFDAALGSPPLPQADSGVKKRRQGKKHAPVKDVDGDEEGDVETPKCGTSRVQKLRERGGEAQSDDGGTAVVREKAERFARKEGKKNARKSEADADTRGASLKGKGKAKAVLDADLDEEPRVEQESEELVQSEDDVTGHDFMRKLHAKRAREAEAIAAEKARKTGKASPAIEINPGRNAGKSYHFYEVERNKAAREQMFAHDCEDCAGYYARAHAGLVVPPDHVRSCNHAKTSKGASSNFLAQRQEAMQDLLQKTSRHRKHHRPDPTPPDFWQMGFPSTAQVNDINARAEEIRQERQRFQLAEASKERGFYRYRDDAPKARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MYF7</accession>
    <name>A0A2X0MYF7_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C005g03684 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C005g03684</name>
        <name evidence="3" type="ORF">BQ5605_C005G03684</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MYF7"/>
    <dbReference type="STRING" id="796604.A0A2X0MYF7"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="2">
        <location>
            <begin position="60"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="453"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="501"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGY77625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="663" mass="73353" checksum="5C2C5014C8A2A8C3" modified="2018-09-12" version="1">MPTRLPTPPPPAPAALSYGPSLITDRQWYLTAKQVAHPPSCDRARLGSWREPITLGEERYARATAMQRIWNLRNMMSCPLVVISTSAILMHRFYMVKSVQDFPPEDVGSAVFFLANKVEENPINLRHIIGYCLAIERKIDREHIRFDAKGRPEYDPNDDLAQNISKRILYTEDAMLHALCFDLTVQSPFFAVVEGLKKVYKKDLEGRDQISFVAWQILQDVLATTLVIRYQAYELAAAAILCALAQLSLPIPRPISRPRESTRGTGEKHGDVEMLDGAEDTSKGGPEGEEGEEVEQDEDLCKVFEVTMDRMRGKGAVCLCFGQIVKLLAETWELGQDPYVVHEGRRLRKYVYRLLDIPHDSSMDQKPLPPEIPRVEPRRKQGSSTPRLAHPASGKTPNSHQQSGGYSTPGDNGPQFAPSQNQRHDTYGAHRPPHEPPSGQGLIPAPPPPPFPELYGTLPQQQGYSNQYNQNIQHHNNQQHNQPIHYPQQQHQQHFPQHTYPNQPNQANHFAPAPPFQPPQLSYGIQNPNQGPPHLNYGARNPMPTGPAAQRVGSGGFGSYPNPDDRFAPAAPPQAPPVQARFRPIGGGLPPTPSGPKFANTMEVSYDDRRRTQGGGGGWATSGTAGSALPPNLPYAASTLPPRPQLQAYDDVTIRSTSMGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0MYH5</accession>
    <name>A0A2X0MYH5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C005g03704 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C005g03704</name>
        <name evidence="2" type="ORF">BQ5605_C005G03704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000047">
        <property type="protein sequence ID" value="SGY77708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0MYH5"/>
    <dbReference type="STRING" id="796604.A0A2X0MYH5"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY77708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="174" mass="18140" checksum="08743E4F700901AA" modified="2018-09-12" version="1">MDSSDPTTPLSPRDPSPLASSISDQLATLQAQLAALQASQHPAAPASATAASQPTAAAATATTASKVVFPKHARLAGPKSFTNWLRQLRLTLPNQIRGYVLDGVVPPTWTADQLAARDDAAREIIVGSIDSADVSATLDAIPSDDLSAPRIFAALKACFAPNDATRTLKLFARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N2I3</accession>
    <name>A0A2X0N2I3_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C004g02654 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C004g02654</name>
        <name evidence="2" type="ORF">BQ5605_C004G02654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY66285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N2I3"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGY66285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="685" mass="76713" checksum="1B19C82EE318C9B8" modified="2018-09-12" version="1">MASLLSPDVDSPCEISPSPPPPAGEPVTDLRLCHCPLCGPQGKSVSSSTIWRYSKQERFSSERTTLPSPGSSPFDKHDLHFDSPTPRRQYALKRQASQEIEGHARVGIFPGTYLASDGGLRFAPRHRVDGSDEYDWTEAGDLNSSPVPFPASPGAEGPLSHPSRSRVNSPPTSFPSGTELSSDSDQDEDTEPRSSDRLDFEEQEFQGDLWCASDEDEPTSPAQTAEEMPSSDDEIEDSSDNELHSNWSASSPVDQLRDDMILEALDAQKDACRMLEFESDELNHFSWLIEARVTRKMVDLYCAGHNIPPFRQLRKTALEWGGLEYLHIDYCENSCMAYYGPTQYDKECAHCGSSRYFSKNMRYRAEYDRQRGNRDPSVMADLFDGSRYLDRLNEYVSYNIPSEEAAAAGDCVPDRTKTFSHKYYENELDVALGLFTDGLQLFDSGASSCWPIILVNYNLPPTLRYQNQHLIPVAIIPGPGQPKNIDSFLEPLYADARRSAEMGHVVFDRYAESSVRQRWYIQFVGGDGLGISKVLGFKGPNSKWPCRVCTIKGITGPKGRKNYYPLKNVTGVPPDPDRPDLQVDDLPMRSEESIRKIAWEVTTGRARLFKDPDMGMNGLARIAFIPGFTKTERWTSCMQRSRTLPSDLSTYGTPQKKIPLLESRRAWNLVPGSLAIKSGRKSGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N320</accession>
    <name>A0A2X0N320_9BASI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mannan endo-1,4-beta-mannosidase</fullName>
            <ecNumber evidence="4">3.2.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BQ5605_C004g02854</name>
        <name evidence="11" type="ORF">BQ5605_C004G02854</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random hydrolysis of (1-&gt;4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.</text>
            <dbReference type="EC" id="3.2.1.78"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.78" evidence="4"/>
    <dbReference type="EMBL" id="FQNC01000046">
        <property type="protein sequence ID" value="SGY68131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0N320"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045053">
        <property type="entry name" value="MAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451:SF39">
        <property type="entry name" value="MANNAN ENDO-1,4-BETA-MANNOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26410">
        <property type="entry name" value="GH5_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016149657" description="mannan endo-1,4-beta-mannosidase" evidence="9">
        <location>
            <begin position="19"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="10">
        <location>
            <begin position="191"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF26410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SGY68131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="581" mass="64473" checksum="C16E914577A3C84D" modified="2018-09-12" version="1">MLHSYLLLVSILVHGAAASWYEAASRLDDTVQPWNRSCPRRVRAQAELLRGVWRDSNGDRISFDLRKRNLEQDFDFVEPAPDFLGLPPLGTAVSSARSARNFAVRPRATGGQGTDYLGTAPINSSVSAVDTIQPEASIIIDGPPASFQGSGSYLEVDPSGTGLTLDGEPFRPVGPRLCNDESLSCLPRGYYTDKSRIREALAAAVAMGANTIRLNSCGISTGFPQAVQPSLHTYGTDEQLDIHDYVIYAAGEYGLKVILPLTDNYDYYHGGKYTFLRWLNVPTDNAGAQFFTDRQVRRAFKRYIKFLLTRVNQYNGLAYGEDPTIAIIEDGNEFGAYMGKEGFPPLSFTEDIAKYVKSLAPQALLMDGTDGFYNYTTKAVAPGVTSPYVDIVTDHAYPRNIALLKRQVDIAHSNGKVFLIGEMDWTPNNGGADFGAYLNLLYNYQSVGVMAWSLFTHDTPCSSYVIHDDAYSIYYPNGPNTSAERSNILKLVQFWYQVTGRDAPSSLPQQTATRLTRFNYNARSMASVAIFDMLEREMRVLPCERLDGLDPSRARPLFTSPSAQQLLQLERVFSNTKRGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0N8I8</accession>
    <name>A0A2X0N8I8_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C025g10018 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C025g10018</name>
        <name evidence="3" type="ORF">BQ5605_C025G10018</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000087">
        <property type="protein sequence ID" value="SGZ26990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="796604.A0A2X0N8I8"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1264"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="652"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="560"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ26990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="2082" mass="232111" checksum="D123221D7249AD39" modified="2018-09-12" version="1">MSTGDPGSPPPAPPPPVSATSVQPPRDQIPISSKKTQATGPATAAPNYAAAASQATQSPEQQQQQQQRAKALGSLLQAMGAVPGNRMDRWVQAIYFAELYPVATATSLKFSALNANRSVENIFDYALEVTLSHQSASRASHADKTDLVACVTRLLSPISPICFEPGVPLPDHLAAYRPQILGVQHSSILRNGAAHHRVTVGFVTGEARDAALTTPPALTWRSAKARFAKSHRFHHNMVELRINVGVQGVPSMDAIIKSFQLLVQDLSGKGHSCQLVQVLRIISVDNASAFAHVAGDYSAFLHFDDDSLFKRPNTTLKEILPSRIDLPTRGIPATALRHDYEKEAACGRCHFVGHVGTCGLDQESKRKEAHNGNGNANTNANKNTITNDTNIVEAEAPIPVPVVNRIASQNRFAGLEVEEGQEEAVTGQSGQGPEESGEEDAGDKADDEDSEDSEMESEATAKTEVIKLKSEDESVLEDCGGSDGEVIDEDEVMADGRGETEGKVATEMEEREVATEMEEEEMATEVDDVDEAGGATKAENAEATDLGETNRLDNDDDSDATATAATASRESTPHEPTPPLSPETLAKSLREGEEWDRIRANWVEQARLERDQSIERRLDAETPLVRHNFATWDEDGEIRSINIRGTASKFKKPVMKRSQTAADLSDPSDEPTDAKRVIIKGKSRVVVKDGTEGRRVTRSMSAAAAMPVGVTKVDRGKAKGVAEEKRWSDHEPEDDRFDLNYPLMIKHTIITWNVRRGMGVPEKRRDIYNYLSLFKASAILIQEHFIRPHLWQLIKDEYEGKLFINQHCLTLIPADSPLIDAELLRTHSALDGRLLVTSFRLRGDIKILEINNVYAPVDPKQRAKFFDKLLFHKTQKSHLRLLGGDLNDCPRPEVDRRNQSRRGHHWPILIGKLDSAYTDCIRYKHPITPSFTRPNPNRKRPNSFSRLDYFLLQRTHQKRLDQASTIYDYPKELSDHRPVLIVLALSDDPDATLPQLSLPTTSNQLHRINTTTFKTVEFQRMMEGWLEGASGEEPVGELEVILKACRDRGGEMARRLHRERTERMEYLVGRVQDMEAIPEWGEAETAEWTRTSEELKRAVEERARLLRIRAHVPEIASEERLSRPVYAKLAARNSDSKITALRLSNGELTHDIDVALDHTQAHFQRLYHIEPRDPDRVDRLRDEFLAPIRAARTCDDPRSDPLFLRRLSESQIDLLQRPITEDEVVAAIGTTHPGRSPGPSGVPYELYQTAPKAWAKVLTKAYNAMIERGSLYPKQGQGLVRLIFKRHKKNADRAELSSYRPITLRECDYKIFTKVYVARLNQILPDLLPPQQHGFVKDRRSADAALHLRLLIEELGARRTEFPAAALLSLDQSSAYDLVEHDWIFAIFDALGAPATFLRVLRMLYSGDSTSARYIINGFLTAPVRLTCGLGQGDPASSSVWDIVFQPFLDALHRRNIALNLSIPALHPYPQSRAITSLAFADDVVVAVAGLGSVNLLDDLALDWRHATNGRLNTDKTVVLPIGRRWDPGQRPLVVKAAGESLEWIGLPFDPSGDTELAYANLIERLEATLEGVQHRWLTHHTRAFYVNRYAIPKILHFLAADIPPPEVVKKLDDMLVDFVRGGNGRTSYGRDIVFTAKLKGGLGVIRMQDVVDAVAARIWDVLLGGSGAIWQGLARAALQRAQSDLDLATDLWPHPSTPIPSDLHPRWRAALGVPKQQDAQVNPRTLTTANLLALPTLLGSLHTPIRGRQTIDAVHIPDYLRLQGYPKVADLYRRELYAGGGFHLWTPPADVLGDNSEYDRRGLPQRLAIAAWYRFTVDRHKNTPLAVAVAAGRLNVPPRIGTSAPLEAILPKPVARFAMEQRLPDPVLPQQASQYKLLNMARPYTIRRIRRVLNAKAFTNTLGLKGPPQPDDLRSFWKAVNSKALTAREREVWFKLILRFTPTRKLQHQQQHDTSPACLVCEAPVDDTDHYFFGCIDSRNVWIAARGVLCDALGCDTIEDAQYTTLQRLFGLPKLKASLRDQEGAGRTIEIFTGLVLEMISSGRWGMQKWGTRMEGVGRRRIILEERLKLRAGGAWGRRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NAN4</accession>
    <name>A0A2X0NAN4_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BQ5605_C052g12586 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BQ5605_C052g12586</name>
        <name evidence="2" type="ORF">BQ5605_C052G12586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000099">
        <property type="protein sequence ID" value="SGZ29997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NAN4"/>
    <dbReference type="STRING" id="796604.A0A2X0NAN4"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090694">
        <property type="term" value="C:Scc2-Scc4 cohesin loading complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061775">
        <property type="term" value="F:cohesin loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140588">
        <property type="term" value="P:chromatin looping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034087">
        <property type="term" value="P:establishment of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071169">
        <property type="term" value="P:establishment of protein localization to chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033031">
        <property type="entry name" value="Scc2/Nipped-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704:SF18">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN DELANGIN SCC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="885"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="310"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SGZ29997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1064" mass="113732" checksum="B2AE81B184F916AB" modified="2018-09-12" version="1">MNGSDDAQANIERSARDLIRGYPLAAGLTSVANGESLSWPVPSPVARCTRLAVVAAEGQCQKPAQDFTNVINHLPPPRPCTPTLFAHPASLSLHAGPQEPLFEQFAQEIGTLLDPTLRNDPYIEQWRQMEMAGAAEALQQPVQAFAHQGYPQGTTSIPPYSVNPSPTGLVAPPAKTLTSQLLDTIGFPYPPLPSMTRVAQNPDADRTLTTDIDRSQSATFFEEYLAAEAQGRLARAPPPPSLLSSPSKSSTSSLMMAQTPPRAGPVNTVFSREKSGCKPPRMLPPTSSPDPLLMSGGASNSFNGHRYARPPQSSSPTASPSRHPSFTLEIEVDASRSPKRRLAAYGTTESQRAHMLVDSDHEVQTPHAAAGMESAVKRFKLGTSSDVDGVDSSSASTSRVLQSGKGTIKANAAQGVVDRLSDLLADLFSSDDSYINDTSSSHVHAAASTAPNLTSENKVFFNESATTIDGLPLLDGAVLRTLIQQLSNVHAKRAGEELLEDVEEGGVARLLKIVERSWSGVEELRVWPHVVANKETNGGGGARARSASNGKRAKFARRGSSESPQKGRGSRGSPRAVESEEELEYDLDEDATTMTTRPHSPKSRSRSRTPSAANALMDVDGVEAADVEPTVATKDERVWTDDTLDDFDRCARHIADAVLAIRVALLVLTMTSLPKSLYSVDYLLSILTSLRYAFDTLIFPLVEAQTDSHLTDLLAGRRTEIQALCESLAATTPLVTRLVQQQELSEEIVISSVYFALGPFFHEAAPAPTGKGKRVDTNVAALAMKGLRMASLGLTRGLYGRYADQRAWIMEEVLGNLTKLDVAKKGRGAIRLRNGFSIHTLSALILNLVQTCETGLCAQVASRIAGADQNGLGLSSSAVFSPTLDEDNDELSWEPAPHQDDAAANGGVDDALDVAYRDLVKPALDAATKSAYTVVSYLLTKSSKAGKASSGSIETEYRAVFDNLIADLLVTLHLPEWPAAEIVLHVCCKSMLNSLADTKSTHEGNALKNIALDHLCSIGARLRQDAASEPPSSTSSATSTVLGNLGDIVGKEDVAALDARDFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NAV1</accession>
    <name>A0A2X0NAV1_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C030g10803 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C030g10803</name>
        <name evidence="3" type="ORF">BQ5605_C030G10803</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000069">
        <property type="protein sequence ID" value="SGZ08571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NAV1"/>
    <dbReference type="STRING" id="796604.A0A2X0NAV1"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="18"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="549"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="623"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="791"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="930"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="798"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="810"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="845"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="861"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="932"/>
            <end position="943"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ08571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="1017" mass="106790" checksum="9DDCFBD3E2645D28" modified="2018-09-12" version="1">METTTPPWNAVIAAIAPLPPAPAAPSSLGMAAGASPSGSGSVLDETTQTTTGTSFDDRAALAPTATTAVENGSIRNDLPTLNIVSERSGLPEEQQFHRVITTTHKPHEEPIPSTSATPHEILISPSLVAPRSTSTPEPPSTTFNNSSSTSSTPPPPAISVLRSNPIRRSSPLKQELLYEDGNISEASFIIEEEEISVPVVAPITLTCTAAAAEVATTPARVTMLKEQIVSKDSSGYLESPCGETSADTSSLFPFHPLYTNHTINQSPNSNDNDDLSLIMNERGSFLLPSDDSLAPTPIKKKKRGELSEIMEDEEEEEEQSANLSQLLKGLREGSPLSIRLGSELGVSTRTLRAQQVGQTRTPSRLGTVEVLASTTKESITASPTPATPTQADESMMDRSKIDDVEELFEKLAERGKGSGSEHGVEDESMLSLFGGRDESIEQGEGMVGSVAKEPTPIPLSQARVQETPADHSITTLEYVQGAWSQLLTAPLASSPVEQEKRVEDESMLSFEMMRDETIGVIEGQLVKSPLAPALESSMSKVGTAAFMASPLGTPEGMRTVRPSSPVARESTPTSKTAAEVPLTTTMAKTVPTPSRGLERLRNKMIALRLEALQTQNQAVIPLGNPTPSTATEPEPDVLPTPSTPVRRPRLSSTILQTPIGSSAAALRLEKYRAMNTPKTVGRDEVVAIKLPTAKEGKGKDEVGASAPRTPSTTMLITPMKTISTLDASAKRHKRSETIQLTSSAGKSLFSPAVGSRTVAGPERGAGTSPLVRMAVAGDRRRSLIATSTAVPSPVKMRSLREGAAEEARPVRSSTTSTATTGRVGTRAGRTGWTTSTTATRPIPSVRSSTYSTTPSRVSLLTGGRPTPRIPTTTTTTTTLLPNFNDQNVAPARSITRPLTTSTTSSSLLPLRSSALLKTRPTFQPRVLKPLVSSRKSSSTTSTSVGDKIATGTRPRFGLGPLPARSTTIGTAPPGAGGGIGVGVGVGARTTTAVTSTRKTLAPVAGARGAVGSRGALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NE00</accession>
    <name>A0A2X0NE00_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C023g09687 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C023g09687</name>
        <name evidence="3" type="ORF">BQ5605_C023G09687</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="FQNC01000085">
        <property type="protein sequence ID" value="SGZ24032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0NE00"/>
    <dbReference type="STRING" id="796604.A0A2X0NE00"/>
    <dbReference type="Proteomes" id="UP000249464">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="2">
        <location>
            <begin position="237"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SGZ24032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249464"/>
        </source>
    </evidence>
    <sequence length="391" mass="43662" checksum="2990B2DC282D7E07" modified="2018-09-12" version="1">MAEPTLSSPHRHLFLRRGKCAGLEPRSNHSSPTFPSATTSAPDGHGKVQLPPLSGPIPSIDSCLKGRIPALKDPACFGYFDAFTIDSAHSRRPESCRQSAPNLCQNMAHLPGRGHRHSTWTRRRRQSHTKIYFDQAQFYAIPTPTREIVDLKTLFSRCTVIDVPMVGPSTKSLARSIRLRCLSVTHYSSPQRKIASTSTFLFARSIKLGHSLPKDRDEEEGDAENGDGELSRSQLFAYYLHKRDEYFSIPHCTQRAFLAFVMTDTPKSRPIDSTYLQLDQENLRLTTGQGIISLTPDQVGCSVILGSTFKNRPRENTQRYQDAMACVVKYGKPSLFITVTCNPKWPEIKAALGPNDQASNRPELIARAFESKLNRLCDDNVSGNKQRAGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0NHK5</accession>
    <name>A0A2X0NHK5_9BASI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BQ5605_C047g12318 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BQ5605_C047g12318</name>
        <name evidence="3" type="ORF">BQ5605_C047G12318</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microbotryum silenes-dioicae</name>
        <dbReference type="NCBI Taxonomy" id="796604"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Pucciniomycotina</taxon>
            <taxon>Microbotryomycetes</taxon>
            <taxon>Microbotryales</taxon>
            <taxon>Microbotryaceae</taxon>
            <taxon>Microbotryum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaros S."/>
                <person name="Januszkiewicz K."/>
                <person name="Wedrychowicz H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text ev
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